Updated on 2023/02/05

写真a

 
EGAWA Jun
 
Organization
University Medical and Dental Hospital Psychiatry Lecturer
Title
Lecturer
External link

Degree

  • 医学博士 ( 2012.9   新潟大学 )

Research Areas

  • Life Science / Psychiatry

Research History

  • Niigata University   Psychiatry, University Medical and Dental Hospital   Lecturer

    2022.4

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Associate Professor

    2016.1 - 2022.3

  • Niigata University   Institute for Research Promotion Center for Transdisciplinary Research   Lecturer

    2013.3 - 2015.12

 

Papers

  • Factor structure of the parental bonding instrument for pregnant Japanese women

    Naoki Fukui, Yuichiro Watanabe, Koyo Hashijiri, Takaharu Motegi, Maki Ogawa, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

    Scientific Reports   12 ( 1 )   2022.11

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    The parental bonding instrument (PBI) is often used to examine the perceptions of children and adolescents regarding parenting practices. Previous studies have investigated the factor structure of the PBI. However, although it is important to examine the relationships between the perceived parenting practices and perinatal mental health, few studies have included perinatal women. We aimed to accurately clarify which PBI factor structure was useful in assessing perinatal women (n = 4633). Furthermore, we evaluated the measurement invariance between primipara and multipara groups, and between the paternal and maternal PBI forms. Our exploratory and confirmatory factor analyses revealed that a three-factor PBI structure was most plausible for perinatal women. Moreover, we found complete invariance (residual invariance) of the PBI ratings across primipara and multipara women for the paternal and maternal forms. In contrast, we found weak invariance (metric invariance) of the PBI ratings across the paternal and maternal forms. Our participants tended to rate fathers as less caring and less overprotective than mothers. This three-factor structure shows measurement invariance in perinatal women and can be used to accurately determine how the perceived parenting style before adolescence influences women’s mental health in the perinatal period.

    DOI: 10.1038/s41598-022-22017-2

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    Other Link: https://www.nature.com/articles/s41598-022-22017-2

  • Novel missense SETD1A variants in Japanese patients with schizophrenia: Resequencing and association analysis. International journal

    Ryo Morikawa, Yuichiro Watanabe, Hirofumi Igeta, Reza K Arta, Masashi Ikeda, Satoshi Okazaki, Satoshi Hoya, Takeo Saito, Ikuo Otsuka, Jun Egawa, Takaki Tanifuji, Nakao Iwata, Toshiyuki Someya

    Psychiatry research   310   114481 - 114481   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    SETD1A has been identified as a substantial risk gene for schizophrenia. To further investigate the role of SETD1A in the genetic etiology of schizophrenia in the Japanese population, we performed resequencing and association analyses. First, we resequenced the SETD1A coding regions of 974 patients with schizophrenia. Then, we genotyped variants, prioritized via resequencing, in 2,027 patients with schizophrenia and 2,664 controls. Next, we examined the association between SETD1A and schizophrenia in 3,001 patients with schizophrenia and 2,664 controls. Finally, we performed a retrospective chart review of patients with prioritized SETD1A variants. We identified two novel missense variants (p.Ser575Pro and p.Glu857Gln) via resequencing. We did not detect these variants in 4,691 individuals via genotyping. These variants were not significantly associated with schizophrenia in the association analysis. Additionally, we found that a schizophrenia patient with the p.Glu857Gln variant had developmental delays. In conclusion, novel SETD1A missense variants were exclusively identified in Japanese patients with schizophrenia. However, our study does not provide evidence for the contribution of these variants to the genetic etiology of schizophrenia in the Japanese population.

    DOI: 10.1016/j.psychres.2022.114481

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  • Theory of mind tested by implicit false belief: a simple and full‐fledged mental state attribution

    Isao Hasegawa, Jun Egawa, Keisuke Kawasaki, Taketsugu Hayashi, Ryota Akikawa, Toshiyuki Someya, Isao Hasegawa

    The FEBS Journal   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/febs.16322

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  • Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients

    Atsunori Sugimoto, Yutaro Suzuki, Kiyohiro Yoshinaga, Naoki Orime, Taketsugu Hayashi, Jun Egawa, Shin Ono, Takuro Sugai, Toshiyuki Someya

    Frontiers in Human Neuroscience   15   2021.11

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    Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    <bold>Objective</bold>: We conducted this non-randomized prospective interventional study to clarify the relationship between improved attention-deficit hyperactivity disorder (ADHD) symptoms and regional brain activity.

    <bold>Methods</bold>: Thirty-one adult patients underwent near-infrared spectroscopy examinations during a go/no-go task, both before and 8 weeks after atomoxetine administration.

    <bold>Results</bold>: Clinical symptoms, neuropsychological results of the go/no-go task, and bilateral lateral prefrontal activity significantly changed. A positive correlation was observed between right dorsolateral prefrontal cortex activity and Conners’ Adult ADHD Rating Scales scores. Before atomoxetine administration, no correlations between prefrontal cortex activity and clinical symptoms were observed in all cases. When participants were divided into atomoxetine-responder and non-responder groups, a positive correlation was observed between prefrontal cortex activity and clinical symptoms in the non-responder group before treatment but not in the responder group, suggesting that non-responders can activate the prefrontal cortex without atomoxetine.

    <bold>Conclusions</bold>: Individuals with increased ADHD symptoms appear to recruit the right dorsolateral prefrontal cortex more strongly to perform the same task than those with fewer symptoms. In clinical settings, individuals with severe symptoms are often observed to perform more difficultly when performing the tasks which individuals with mild symptoms can perform easily. The atomoxetine-responder group was unable to properly activate the right dorsolateral prefrontal cortex when necessary, and the oral administration of atomoxetine enabled these patients to activate this region. In brain imaging studies of heterogeneous syndromes such as ADHD, the analytical strategy used in this study, involving drug-responsivity grouping, may effectively increase the signal-to-noise ratio.

    DOI: 10.3389/fnhum.2021.755025

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  • Perceived parenting before adolescence and parity have direct and indirect effects via depression and anxiety on maternal-infant bonding in the perinatal period. International journal

    Naoki Fukui, Takaharu Motegi, Yuichiro Watanabe, Koyo Hashijiri, Ryusuke Tsuboya, Maki Ogawa, Takuro Sugai, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

    Psychiatry and clinical neurosciences   75 ( 10 )   312 - 317   2021.7

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    AIM: This study aimed to detect how the perceived parenting practices before adolescence affect maternal-infant bonding in the perinatal period, considering factors such as depression, anxiety and parity. METHODS: We used the Parental Bonding Instrument (PBI) to examine the perceived parenting practices. Participants included 1301 pregnant women who completed the Hospital Anxiety and Depression Scale (HADS) and Mother-to-Infant Bonding Scale (MIBS) at three time points: early pregnancy (approximately 12-15 weeks), late pregnancy (approximately 30-34 weeks) and postpartum (4 weeks after childbirth). We performed a path analysis with factors including parity, PBI subscales (paternal care, paternal overprotection, maternal care and maternal overprotection), HADS and MIBS. RESULTS: Perceived paternal or maternal low care parenting predicted higher HADS and MIBS scores in early pregnancy. Moreover, perceived maternal low care parenting predicted higher HADS scores at postpartum and higher MIBS scores in late pregnancy. Perceived paternal or maternal overprotective parenting predicted higher HADS scores in the pregnancy period. Furthermore, perceived maternal overprotective parenting predicted higher MIBS scores in late pregnancy. Being primipara predicted higher HADS scores at postpartum and higher MIBS scores in early pregnancy and at postpartum. Being multipara predicted higher MIBS scores in late pregnancy. CONCLUSION: This study suggests that perceived negative parenting before adolescence has indirect effects (via anxiety and depression) and direct effects on maternal-infant bonding in the perinatal period. This article is protected by copyright. All rights reserved.

    DOI: 10.1111/pcn.13289

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  • The lowest effective plasma concentration of atomoxetine in pediatric patients with attention deficit/hyperactivity disorder

    Atsunori Sugimoto, Yutaro Suzuki, Naoki Orime, Taketsugu Hayashi, Kiyohiro Yoshinaga, Jun Egawa, Shin Ono, Takuro Sugai, Yoshimasa Inoue, Toshiyuki Someya

    Medicine   100 ( 27 )   e26552 - e26552   2021.7

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    Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1097/md.0000000000026552

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  • Exclusive Breastfeeding Is Not Associated with Maternal-Infant Bonding in Early Postpartum, Considering Depression, Anxiety, and Parity. International journal

    Naoki Fukui, Takaharu Motegi, Yuichiro Watanabe, Koyo Hashijiri, Ryusuke Tsuboya, Maki Ogawa, Takuro Sugai, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

    Nutrients   13 ( 4 )   2021.4

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    It is important to clarify how the breastfeeding method affects women's mental health, and how women's mental health affects the breastfeeding method in the early postpartum period when major depression and other psychiatric problems are most likely to occur. This study aimed to examine this bidirectional relationship in the early postpartum period. Participants were 2020 postpartum women who completed the Hospital Anxiety and Depression Scale (HADS) and Mother-to-Infant Bonding Scale (MIBS). We obtained data for participants' breastfeeding method for four weeks after childbirth. We performed a path analysis with factors including breastfeeding method (exclusive breastfeeding or non-exclusive breastfeeding), parity (primipara or multipara), the two HADS subscales (anxiety and depression), and the two MIBS subscales (lack of affection and anger and rejection). The path analysis showed that breastfeeding method did not significantly affect depression, anxiety, and maternal-infant bonding in the early postpartum period. Women with higher anxiety tended to use both formula-feeding and breastfeeding. Our study suggests that exclusive breastfeeding is not associated with maternal-fetal bonding in early postpartum, considering depression, anxiety, and parity.

    DOI: 10.3390/nu13041184

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  • Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population

    Reza K. Arta, Yuichiro Watanabe, Emiko Inoue, Yoshihiro Nawa, Ryo Morikawa, Jun Egawa, Itaru Kushima, Hirofumi Igeta, Satoshi Hoya, Atsunori Sugimoto, Andi J. Tanra, Norio Ozaki, Toshiyuki Someya

    RESEARCH IN AUTISM SPECTRUM DISORDERS   82   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    Background: Growth-associated protein 43 (GAP43), a synaptic protein involved in axonal growth and synaptic plasticity, is implicated in the pathophysiology of autism spectrum disorder (ASD) and schizophrenia. To examine the role of rare GAP43 variants in the genetic etiology of ASD and schizophrenia in a Japanese population, we performed resequencing and association analysis.Methods: First, we resequenced the GAP43 coding region in 295 ASD patients, 323 schizophrenia patients and 304 controls. Second, we genotyped rs561268447 in 273 ASD patients, 1,150 schizophrenia patients and 1,022 controls. Third, we performed an association analysis of rs561268447 in 568 ASD patients, 1,473 schizophrenia patients and 10,127 controls.Results: We identified a rare putatively damaging missense variant (rs561268447) in an ASD patient via resequencing. However, we did not detect the variant in 2,445 individuals via genotyping. The variant was not significantly associated with ASD or schizophrenia in the association analysis.Conclusion: This study does not provide evidence for the contribution of rare GAP43 variants to ASD or schizophrenia susceptibility in the Japanese population.

    DOI: 10.1016/j.rasd.2021.101729

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  • 視線認知課題遂行時の脳内活動計測 自閉スペクトラム症の病態解明に向けて

    村松 優希, 杉本 篤言, 吉永 清宏, 林 剛丞, 江川 純, 飯島 淳彦, 染矢 俊幸

    小児の精神と神経   60 ( 4 )   299 - 307   2021.1

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    Language:Japanese   Publisher:(一社)日本小児精神神経学会  

    【目的】自閉スペクトラム症の視線認知における脳内基盤解明を目指し、定型発達の視線認知活動を捉えることを目的とした。【対象と方法】定型発達3名を対象として視線認知課題中の脳活動を脳磁図(MEG)で記録した。課題では、研究対象者に「手がかり刺激が示す方向に従い、左右どちらかに呈示される標的刺激へ視線を移動する」よう教示した。手がかり刺激には、側方視した両眼の写真(Gaze条件)と矢印図形(Arrow条件)の2種類を用意した。脳磁図の解析は、刺激呈示から-100〜700msの区間を、2条件それぞれ約128回加算平均した。結果をSPM12によりMSP法を用いて分布電流源推定を行った。【結果】Gaze条件では、刺激呈示後160〜200msで顔および視線の動きに特有の反応であるM170がみられた。これらの活動は紡錘状回および上側頭溝付近にみられた。【結語】Gaze条件で「視線の動き」を認知する脳活動が観察されたため、本課題により視線認知における脳内活動を検出できる可能性が示唆された。(著者抄録)

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  • Factor Structure and Measurement Invariance of the Hospital Anxiety and Depression Scale Across the Peripartum Period Among Pregnant Japanese Women. International journal

    Maki Ogawa, Yuichiro Watanabe, Takaharu Motegi, Naoki Fukui, Koyo Hashijiri, Ryusuke Tsuboya, Takuro Sugai, Jun Egawa, Rie Araki, Kazufumi Haino, Masayuki Yamaguchi, Koji Nishijima, Takayuki Enomoto, Toshiyuki Someya

    Neuropsychiatric disease and treatment   17   221 - 227   2021

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    Purpose: The Hospital Anxiety and Depression Scale (HADS) is a self-report questionnaire widely used to assess anxiety and depression. To the best of our knowledge, only four studies have examined the factor structure of the HADS for assessing pregnant women, with conflicting results. This study aimed to assess the factor structure and measurement invariance of the HADS for use with pregnant Japanese women. Participants and Methods: A total of 936 pregnant Japanese women completed the HADS questionnaire at three time points: the first and third trimester of pregnancy, and postpartum. We examined the factor structure of the HADS in Group 1 (n = 466) using exploratory factor analysis (EFA). We then compared the models identified in Group 1 with those from previous studies using confirmatory factor analysis (CFA) in Group 2 (n = 470). We performed multiple-group CFA for Group 2 to test the measurement invariance of the best-fit model across the three time points. Results: The EFA for the Group 1 data at the three time points revealed a two-factor model. In the CFA, the two-factor model from Group 1 showed the best fit with the data at the three time points. In the multiple-group CFA for Group 2, we confirmed the configural and metric invariance of the two-factor model across the three time points. Conclusion: Our findings provide evidence for a two-factor structure and weak measurement invariance of the HADS in pregnant Japanese women during the peripartum period.

    DOI: 10.2147/NDT.S294918

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  • Identification of Bonding Difficulties in the Peripartum Period Using the Mother-to-Infant Bonding Scale-Japanese Version and Its Tentative Cutoff Points. International journal

    Koyo Hashijiri, Yuichiro Watanabe, Naoki Fukui, Takaharu Motegi, Maki Ogawa, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

    Neuropsychiatric disease and treatment   17   3407 - 3413   2021

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    Purpose: Identification of pregnant women with bonding difficulties is important to provide early intervention. However, few studies have examined the utility of self-report questionnaires that assess mother-infant bonding as screening tools for bonding difficulties. This longitudinal study aimed to identify pregnant women with bonding difficulties using the Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) and to estimate its optimal cutoff points in the peripartum period. Patients and Methods: A total of 1301 pregnant women completed the MIBS-J and Hospital Anxiety and Depression Scale (HADS) at three time points: first trimester (T1; approximately 12-15 weeks gestation), third trimester (T2; approximately 30-34 weeks gestation), and postpartum (T3; approximately 4 weeks postpartum). A two-step cluster analysis was conducted to classify pregnant women based on their MIBS-J subscale scores at the three time points. Based on the cluster analysis results, receiver operating characteristic curve analysis was performed to estimate the optimal cutoff scores for the MIBS-J total score at each time point. Results: The two-step cluster analysis produced two clusters: Cluster 1 (n = 824) and Cluster 2 (n = 477). Both the MIBS-J and HADS scores were significantly higher in Cluster 2 than in Cluster 1 at all time points. The MIBS-J tentative cutoff points were 3/4, 3/4, and 2/3 at T1, T2, and T3, respectively. Conclusion: We identified two distinct groups across the perinatal period: pregnant women with bonding difficulties and pregnant women with normal bonding. Our findings suggest the usefulness of the MIBS-J as a screening tool to identify bonding difficulties during pregnancy.

    DOI: 10.2147/NDT.S336819

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  • Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder

    Hidekazu Kato, Itaru Kushima, Daisuke Mori, Akira Yoshimi, Branko Aleksic, Yoshihiro Nawa, Miho Toyama, Sho Furuta, Yanjie Yu, Kanako Ishizuka, Hiroki Kimura, Yuko Arioka, Keita Tsujimura, Mako Morikawa, Takashi Okada, Toshiya Inada, Masahiro Nakatochi, Keiko Shinjo, Yutaka Kondo, Kozo Kaibuchi, Yasuko Funabiki, Ryo Kimura, Toshimitsu Suzuki, Kazuhiro Yamakawa, Masashi Ikeda, Nakao Iwata, Tsutomu Takahashi, Michio Suzuki, Yuko Okahisa, Manabu Takaki, Jun Egawa, Toshiyuki Someya, Norio Ozaki

    Translational Psychiatry   10 ( 1 )   2020.12

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    <title>Abstract</title>Dysregulation of epigenetic processes involving histone methylation induces neurodevelopmental impairments and has been implicated in schizophrenia (SCZ) and autism spectrum disorder (ASD). Variants in the gene encoding lysine demethylase 4C (<italic>KDM4C</italic>) have been suggested to confer a risk for such disorders. However, rare genetic variants in <italic>KDM4C</italic> have not been fully evaluated, and the functional impact of the variants has not been studied using patient-derived cells. In this study, we conducted copy number variant (CNV) analysis in a Japanese sample set (2605 SCZ and 1141 ASD cases, and 2310 controls). We found evidence for significant associations between CNVs in <italic>KDM4C</italic> and SCZ (<italic>p</italic> = 0.003) and ASD (<italic>p</italic> = 0.04). We also observed a significant association between deletions in <italic>KDM4C</italic> and SCZ (corrected <italic>p</italic> = 0.04). Next, to explore the contribution of single nucleotide variants in <italic>KDM4C</italic>, we sequenced the coding exons in a second sample set (370 SCZ and 192 ASD cases) and detected 18 rare missense variants, including p.D160N within the JmjC domain of KDM4C. We, then, performed association analysis for p.D160N in a third sample set (1751 SCZ and 377 ASD cases, and 2276 controls), but did not find a statistical association with these disorders. Immunoblotting analysis using lymphoblastoid cell lines from a case with <italic>KDM4C</italic> deletion revealed reduced KDM4C protein expression and altered histone methylation patterns. In conclusion, this study strengthens the evidence for associations between <italic>KDM4C</italic> CNVs and these two disorders and for their potential functional effect on histone methylation patterns.

    DOI: 10.1038/s41398-020-01107-7

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    Other Link: http://www.nature.com/articles/s41398-020-01107-7

  • Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia. Reviewed International journal

    Kanako Ishizuka, Tomoyuki Yoshida, Takeshi Kawabata, Ayako Imai, Hisashi Mori, Hiroki Kimura, Toshiya Inada, Yuko Okahisa, Jun Egawa, Masahide Usami, Itaru Kushima, Mako Morikawa, Takashi Okada, Masashi Ikeda, Aleksic Branko, Daisuke Mori, Toshiyuki Someya, Nakao Iwata, Norio Ozaki

    Journal of neurodevelopmental disorders   12 ( 1 )   25 - 25   2020.9

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    BACKGROUND: Rare genetic variants contribute to the etiology of both autism spectrum disorder (ASD) and schizophrenia (SCZ). Most genetic studies limit their focus to likely gene-disrupting mutations because they are relatively easier to interpret their effects on the gene product. Interpretation of missense variants is also informative to some pathophysiological mechanisms of these neurodevelopmental disorders; however, their contribution has not been elucidated because of relatively small effects. Therefore, we characterized missense variants detected in NRXN1, a well-known neurodevelopmental disease-causing gene, from individuals with ASD and SCZ. METHODS: To discover rare variants with large effect size and to evaluate their role in the shared etiopathophysiology of ASD and SCZ, we sequenced NRXN1 coding exons with a sample comprising 562 Japanese ASD and SCZ patients, followed by a genetic association analysis in 4273 unrelated individuals. Impact of each missense variant detected here on cell surface expression, interaction with NLGN1, and synaptogenic activity was analyzed using an in vitro functional assay and in silico three-dimensional (3D) structural modeling. RESULTS: Through mutation screening, we regarded three ultra-rare missense variants (T737M, D772G, and R856W), all of which affected the LNS4 domain of NRXN1α isoform, as disease-associated variants. Diagnosis of individuals with T737M, D772G, and R856W was 1ASD and 1SCZ, 1ASD, and 1SCZ, respectively. We observed the following phenotypic and functional burden caused by each variant. (i) D772G and R856W carriers had more serious social disabilities than T737M carriers. (ii) In vitro assay showed reduced cell surface expression of NRXN1α by D772G and R856W mutations. In vitro functional analysis showed decreased NRXN1α-NLGN1 interaction of T737M and D772G mutants. (iii) In silico 3D structural modeling indicated that T737M and D772G mutations could destabilize the rod-shaped structure of LNS2-LNS5 domains, and D772G and R856W could disturb N-glycan conformations for the transport signal. CONCLUSIONS: The combined data suggest that missense variants in NRXN1 could be associated with phenotypes of neurodevelopmental disorders beyond the diagnosis of ASD and/or SCZ.

    DOI: 10.1186/s11689-020-09325-2

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  • 統合失調症罹患同胞対・両親の全エクソームシーケンスおよびSPATA7遺伝子リシーケンスと関連解析

    井桁 裕文, 渡部 雄一郎, 森川 亮, 池田 匡志, 大塚 郁夫, 保谷 智史, 小泉 暢大栄, 江川 純, 菱本 明豊, 岩田 仲生, 染矢 俊幸

    精神神経学雑誌   ( 2020特別号 )   S306 - S306   2020.9

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • 統合失調症罹患同胞対・両親の全エクソームシーケンスおよびSPATA7遺伝子リシーケンスと関連解析

    井桁 裕文, 渡部 雄一郎, 森川 亮, 池田 匡志, 大塚 郁夫, 保谷 智史, 小泉 暢大栄, 江川 純, 菱本 明豊, 岩田 仲生, 染矢 俊幸

    精神神経学雑誌   ( 2020特別号 )   S306 - S306   2020.9

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  • 【精神科作業療法】(第1章)総論 DSM-IVからDSM-5への変更点

    吉永 清宏, 杉本 篤言, 江川 純, 染矢 俊幸

    作業療法ジャーナル   54 ( 8 )   756 - 762   2020.7

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    Language:Japanese   Publisher:(株)三輪書店  

    <文献概要>はじめに 米国精神医学会(American Psychiatric Association:APA)は,2013年5月に精神疾患の診断分類体系であるDiagnostic and Statistical of Mental Disorders(DSM)の第5版(DSM-5)を発表した.前回の改訂版(DSM-IV,1994年)以来,19年ぶりの改定となり,数多くの改訂がみられた.ここでは自閉スペクトラム症の新設,双極性障害の独立や物質使用障害の再編等,従来の診断カテゴリーから大幅な変更が施された部分を中心に概説する.

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  • 自閉スペクトラム症の病態解明に向けた脳磁図による視線認知課題遂行時の脳活動計測

    村松 優希, 杉本 篤言, 吉永 清宏, 林 剛丞, 江川 純, 飯島 淳彦, 染矢 俊幸

    小児の精神と神経   60 ( 1 )   72 - 73   2020.4

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  • トラウマの開示とそれに対する治療によって症状改善を示した症例のケースシリーズ

    杉本 篤言, 吉永 清宏, 林 剛丞, 江川 純, 染矢 俊幸

    小児の精神と神経   60 ( 1 )   82 - 82   2020.4

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  • Macaques Exhibit Implicit Gaze Bias Anticipating Others' False-Belief-Driven Actions via Medial Prefrontal Cortex. Reviewed International journal

    Taketsugu Hayashi, Ryota Akikawa, Keisuke Kawasaki, Jun Egawa, Takafumi Minamimoto, Kazuto Kobayashi, Shigeki Kato, Yukiko Hori, Yuji Nagai, Atsuhiko Iijima, Toshiyuki Someya, Isao Hasegawa

    Cell reports   30 ( 13 )   4433 - 4444   2020.3

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    The ability to infer others' mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) to others, has been considered to be uniquely hominid and to accompany the activation of a distributed brain network. We challenge the taxon specificity of this ability and identify the causal brain locus by introducing an anticipatory-looking FB paradigm combined with chemogenetic neuronal manipulation in macaque monkeys. We find spontaneous gaze bias of macaques implicitly anticipating others' FB-driven actions. Silencing of the medial prefrontal neuronal activity with inhibitory designer receptor exclusively activated by designer drugs (DREADDs) specifically eliminates the implicit gaze bias while leaving the animals' visually guided and memory-guided tracking abilities intact. Thus, neuronal activity in the medial prefrontal cortex could have a causal role in FB-attribution-like behaviors in the primate lineage, emphasizing the importance of probing the neuronal mechanisms underlying theory of mind with relevant macaque animal models.

    DOI: 10.1016/j.celrep.2020.03.013

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  • マカクザルにおける他者の誤信念理解に内側前頭前野が因果的役割を果たす

    秋川 諒太, 林 剛丞, 川嵜 圭祐, 江川 純, 南本 敬史, 小林 和人, 加藤 成樹, 堀 由紀子, 永井 裕司, 飯島 淳彦, 染矢 俊幸, 長谷川 功

    日本生理学雑誌   82 ( 1 )   10 - 10   2020.2

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  • 新潟県における周産期メンタルヘルス研究の取り組み

    茂木 崇治, 福井 直樹, 藤田 真貴, 須貝 拓朗, 江川 純, 橋尻 洸陽, 坪谷 隆介, 三留 節子, 荒木 理恵, 生野 寿史, 山口 雅幸, 西島 浩二, 高桑 好一, 榎本 隆之, 染矢 俊幸

    新潟県医師会報   ( 838 )   7 - 8   2020.1

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    妊産婦自身の被養育体験、パートナーとの関係性、対人コミュニケーション能力などの妊産婦自身の発達特性、周産期の不安や抑うつ、アタッチメントやボンディング、以上の項目の相互の関連について検討した。さらに、本研究で同定された関連性に対して、産科学的情報も加味しながら産婦人科および小児科と連携し、精神医学的立場から妊産婦を対象とした適切な介入システムを構築した。妊娠初期(妊娠12週〜15週前後)、後期(妊娠30〜34週)、産後(1ヵ月)の妊産婦を対象にアンケート調査を実施する。周産期のメンタルヘルスや子どもとのアタッチメント形成を予測する因子を同定することで、精神科医の早期からの適切な介入が可能となり、妊産婦の自殺予防に大きく貢献可能であると同時に、子どもとの良好なアタッチメント形成に寄与できる点において、大きな意義があると考えられた。

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  • Depression, Anxiety and Primiparity are Negatively Associated with Mother-Infant Bonding in Japanese Mothers. International journal

    Takaharu Motegi, Yuichiro Watanabe, Naoki Fukui, Maki Ogawa, Koyo Hashijiri, Ryusuke Tsuboya, Takuro Sugai, Jun Egawa, Rie Araki, Kazufumi Haino, Masayuki Yamaguchi, Koji Nishijima, Takayuki Enomoto, Toshiyuki Someya

    Neuropsychiatric disease and treatment   16   3117 - 3122   2020

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    Purpose: Postpartum depression is a well-known risk factor, and postpartum anxiety and parity are potential risk factors, for mother-infant bonding disorder. However, few studies have focused on the relationships among these factors and mother-infant bonding. This cross-sectional study explored the associations between depression, anxiety and parity, and mother-infant bonding. Materials and Methods: Japanese mothers, both primiparas and multiparas, completed the Mother-to-Infant Bonding Scale (MIBS) and the Hospital Anxiety and Depression Scale (HADS) one month after childbirth. We performed a stepwise multiple regression analysis with the forward selection method to assess the effects of HADS anxiety and depression scores and parity as independent variables on mother-infant bonding as the dependent variable. Results: A total of 2379 Japanese mothers (1116 primiparas and 1263 multiparas) took part in the study. MIBS score (2.89 ± 2.68 vs 1.60 ± 2.11; p < 0.0001) was significantly higher in primiparas than in multiparas. HADS anxiety (6.55 ± 4.06 vs 4.63 ± 3.41; p < 0.0001) and depression (6.56 ± 3.43 vs 5.98 ± 3.20; p < 0.0001) scores were also significantly higher in primiparas than in multiparas. A stepwise multiple regression analysis with the forward selection method revealed that HADS depression and anxiety scores and parity were significantly associated with MIBS score (p = 0.003, 0.015 and 0.023). Conclusion: Depression, anxiety and primiparity were negatively associated with mother-infant bonding one month after childbirth.

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  • 自閉スペクトラム症の病態解明に向けた脳磁図による視線認知課題遂行時の脳活動計測

    村松 優希, 杉本 篤言, 吉永 清宏, 山田 千沙, 林 剛丞, 江川 純, 白水 洋史, 飯島 淳彦, 長谷川 功, 染谷 俊幸

    日本小児精神神経学会プログラム・抄録集   122回   56 - 56   2019.11

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  • Identifying the factor structure of the Mother-to-Infant Bonding Scale for post-partum women and examining its consistency during pregnancy. Reviewed International journal

    Takaharu Motegi, Naoki Fukui, Koyo Hashijiri, Ryusuke Tsuboya, Takuro Sugai, Jun Egawa, Setsuko Mitome, Rie Araki, Kazufumi Haino, Masayuki Yamaguchi, Koichi Takakuwa, Takayuki Enomoto, Toshiyuki Someya

    Psychiatry and clinical neurosciences   73 ( 10 )   661 - 662   2019.10

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    DOI: 10.1111/pcn.12920

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  • マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

    林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019.6

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  • Rare compound heterozygous missense SPATA7 variations and risk of schizophrenia; whole-exome sequencing in a consanguineous family with affected siblings, follow-up sequencing and a case-control study. Reviewed International journal

    Hirofumi Igeta, Yuichiro Watanabe, Ryo Morikawa, Masashi Ikeda, Ikuo Otsuka, Satoshi Hoya, Masataka Koizumi, Jun Egawa, Akitoyo Hishimoto, Nakao Iwata, Toshiyuki Someya

    Neuropsychiatric disease and treatment   15   2353 - 2363   2019

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    Purpose: Whole-exome sequencing (WES) of multiplex families is a promising strategy for identifying causative variations for common diseases. To identify rare recessive risk variations for schizophrenia, we performed a WES study in a consanguineous family with affected siblings. We then performed follow-up sequencing of SPATA7 in schizophrenia-affected families. In addition, we performed a case-control study to investigate association between SPATA7 variations and schizophrenia. Patients and methods: WES was performed on two affected siblings and their unaffected parents, who were second cousins, of a multiplex schizophrenia family. Subsequently, we sequenced the coding region of SPATA7, a potential risk gene identified by the WES analysis, in 142 affected offspring from 137 families for whom parental DNA samples were available. We further tested rare recessive SPATA7 variations, identified by WES and sequencing, for associations with schizophrenia in 2,756 patients and 2,646 controls. Results: Our WES analysis identified rare compound heterozygous missense SPATA7 variations, p.Asp134Gly and p.Ile332Thr, in both affected siblings. Sequencing SPATA7 coding regions from 137 families identified no rare recessive variations in affected offspring. In the case-control study, we did not detect the rare compound heterozygous SPATA7 missense variations in patients or controls. Conclusion: Our data does not support the role of the rare compound heterozygous SPATA7 missense variations p.Asp134Gly and p.Ile332Thr in conferring a substantial risk of schizophrenia.

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  • Rare Single-Nucleotide DAB1 Variants and their Contribution to Schizophrenia and Autism Spectrum Disorder Susceptibility. Reviewed

    Nawa Y, Kimura H, Kato H, Toyama M, Furuta S, Yu Y, Ishizuka K, Kushima I, Aleksic B, Arioka Y, Mori D, Morikawa M, Okada T, Toshiya I, Ikeda M, Iwata N, Suzuki M, Okahisa Y, Egawa J, Someya T, Nishimura F, Sasaki T, Ozaki N

    Scientific Reports   in press   2019

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  • マカクザルを用いた心の理論の脳基盤研究

    江川 純, 林 剛丞, 染矢 俊幸

    新潟医学会雑誌   132 ( 10 )   361 - 362   2018.10

  • 統合失調症患者におけるSETD1A遺伝子の稀な変異のスクリーニング

    保谷 智史, 井桁 裕文, 渡部 雄一郎, 布川 綾子, 江川 純, 井上 絵美子, 杉本 篤言, 林 剛丞, 折目 直樹, 澁谷 雅子, 染矢 俊幸

    新潟医学会雑誌   132 ( 10 )   362 - 362   2018.10

  • Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights. Reviewed International journal

    Itaru Kushima, Branko Aleksic, Masahiro Nakatochi, Teppei Shimamura, Takashi Okada, Yota Uno, Mako Morikawa, Kanako Ishizuka, Tomoko Shiino, Hiroki Kimura, Yuko Arioka, Akira Yoshimi, Yuto Takasaki, Yanjie Yu, Yukako Nakamura, Maeri Yamamoto, Tetsuya Iidaka, Shuji Iritani, Toshiya Inada, Nanayo Ogawa, Emiko Shishido, Youta Torii, Naoko Kawano, Yutaka Omura, Toru Yoshikawa, Tokio Uchiyama, Toshimichi Yamamoto, Masashi Ikeda, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Ayako Nunokawa, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Akiko Kobori, Michio Suzuki, Tsutomu Takahashi, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Tsukasa Sasaki, Hitoshi Kuwabara, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Yosuke Eriguchi, Seico Benner, Masaki Kojima, Walid Yassin, Toshio Munesue, Shigeru Yokoyama, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Makoto Ishitobi, Tetsuro Ohmori, Shusuke Numata, Takeo Yoshikawa, Tomoko Toyota, Kazuhiro Yamakawa, Toshimitsu Suzuki, Yushi Inoue, Kentaro Nakaoka, Yu-Ichi Goto, Masumi Inagaki, Naoki Hashimoto, Ichiro Kusumi, Shuraku Son, Toshiya Murai, Tempei Ikegame, Naohiro Okada, Kiyoto Kasai, Shohko Kunimoto, Daisuke Mori, Nakao Iwata, Norio Ozaki

    Cell reports   24 ( 11 )   2838 - 2856   2018.9

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    Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ cases, and 2,095 controls in a Japanese population and confirmed an increased burden of rare exonic CNVs in both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to both disorders, were found in about 8% of ASD and SCZ cases, which was significantly higher than in controls. Phenotypic analysis revealed an association between clinically significant CNVs and intellectual disability. Gene set analysis showed significant overlap of biological pathways in both disorders including oxidative stress response, lipid metabolism/modification, and genomic integrity. Finally, based on bioinformatics analysis, we identified multiple disease-relevant genes in eight well-known ASD/SCZ-associated CNV loci (e.g., 22q11.2, 3q29). Our findings suggest an etiological overlap of ASD and SCZ and provide biological insights into these disorders.

    DOI: 10.1016/j.celrep.2018.08.022

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  • Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility. Reviewed International journal

    Yanjie Yu, Yingni Lin, Yuto Takasaki, Chenyao Wang, Hiroki Kimura, Jingrui Xing, Kanako Ishizuka, Miho Toyama, Itaru Kushima, Daisuke Mori, Yuko Arioka, Yota Uno, Tomoko Shiino, Yukako Nakamura, Takashi Okada, Mako Morikawa, Masashi Ikeda, Nakao Iwata, Yuko Okahisa, Manabu Takaki, Shinji Sakamoto, Toshiyuki Someya, Jun Egawa, Masahide Usami, Masaki Kodaira, Akira Yoshimi, Tomoko Oya-Ito, Branko Aleksic, Kinji Ohno, Norio Ozaki

    Translational psychiatry   8 ( 1 )   12 - 12   2018.1

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    In schizophrenia (SCZ) and autism spectrum disorder (ASD), the dysregulation of glutamate transmission through N-methyl-D-aspartate receptors (NMDARs) has been implicated as a potential etiological mechanism. Previous studies have accumulated evidence supporting NMDAR-encoding genes' role in etiology of SCZ and ASD. We performed a screening study for exonic regions of GRIN1, GRIN2A, GRIN2C, GRIN2D, GRIN3A, and GRIN3B, which encode NMDAR subunits, in 562 participates (370 SCZ and 192 ASD). Forty rare variants were identified including 38 missense, 1 frameshift mutation in GRIN2C and 1 splice site mutation in GRIN2D. We conducted in silico analysis for all variants and detected seven missense variants with deleterious prediction. De novo analysis was conducted if pedigree samples were available. The splice site mutation in GRIN2D is predicted to result in intron retention by minigene assay. Furthermore, the frameshift mutation in GRIN2C and splice site mutation in GRIN2D were genotyped in an independent sample set comprising 1877 SCZ cases, 382 ASD cases, and 2040 controls. Both of them were revealed to be singleton. Our study gives evidence in support of the view that ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes may contribute to possible risk of SCZ.

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  • Rare PDCD11 variations are not associated with risk of schizophrenia in Japan. Reviewed International journal

    Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Naofumi Shinmyo, Ikuo Otsuka, Shujiro Okuda, Emiko Inoue, Hirofumi Igeta, Masako Shibuya, Jun Egawa, Naoki Orime, Ichiro Sora, Toshiyuki Someya

    Psychiatry and clinical neurosciences   71 ( 11 )   780 - 788   2017.11

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    AIM: Rare gene variations are thought to confer substantial risk for schizophrenia. We performed a three-stage study to identify rare variations that have a strong impact on the risk of developing schizophrenia. METHODS: In the first stage, we prioritized rare missense variations using whole-exome sequencing (WES) data from three families, consisting of a proband, an affected sibling, and parents. In the second stage, we performed targeted resequencing of the PDCD11 coding region in 96 patients. In the third stage, we conducted an association study of rare PDCD11 variations with schizophrenia in a total of 1357 patients and 1394 controls. RESULTS: Via WES, we identified two rare missense PDCD11 variations, p.(Asp961Asn) and p.(Val1240Leu), shared by two affected siblings within families. Targeted resequencing of the PDCD11 coding region identified three rare non-synonymous variations: p.(Asp961Asn), p.(Phe1835del), and p.(Arg1837His). The case-control study demonstrated no significant associations between schizophrenia and four rare PDCD11 variations: p.(Asp961Asn), p.(Val1240Leu), p.(Phe1835del), and p.(Arg1837His). CONCLUSION: Our data do not support the role of rare PDCD11 variations in conferring substantial risk for schizophrenia in the Japanese population.

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  • Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies. Reviewed International journal

    Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Emiko Inoue, Hirofumi Igeta, Ikuo Otsuka, Masako Shibuya, Jun Egawa, Ichiro Sora, Toshiyuki Someya

    Psychiatry and clinical neurosciences   71 ( 8 )   562 - 568   2017.8

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    AIM: Rare variations are suggested to play a role in the genetic etiology of schizophrenia; to further investigate their role, we performed a three-stage study in a Japanese population. METHODS: In the first stage, we performed whole-exome sequencing (WES) of two parent-affected offspring trios. In the second stage, we resequenced the FBXO18 coding region in 96 patients. In the third stage, we tested rare non-synonymous FBXO18 variations for association with schizophrenia in two independent populations comprising a total of 1376 patients and 1496 controls. RESULTS: A rare frameshift variation (L116fsX) in the FBXO18 gene was recurrently identified by WES in both trios. Resequencing FBXO18 coding regions, we detected three rare non-synonymous variations (V15L, L116fsX, and V1006I). However, there were no significant associations between these rare FBXO18 variations and schizophrenia in the case-control study. CONCLUSION: Our present study does not provide evidence for the contribution of rare non-synonymous FBXO18 variations to the genetic etiology of schizophrenia in the Japanese population. However, to draw a definitive conclusion, further studies should be performed using sufficiently large sample sizes.

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  • Sex Differences in the Effect of Atomoxetine on the QT Interval in Adult Patients With Attention-Deficit Hyperactivity Disorder. Reviewed International journal

    Yutaro Suzuki, Misuzu Tajiri, Atsunori Sugimoto, Naoki Orime, Taketsugu Hayashi, Jun Egawa, Takuro Sugai, Yoshimasa Inoue, Toshiyuki Someya

    Journal of clinical psychopharmacology   37 ( 1 )   27 - 31   2017.2

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    BACKGROUND: The effects of atomoxetine on QT in adults remain unclear. In this study, we examined whether the use of atomoxetine to treat attention-deficit hyperactivity disorder in adults is associated with QT prolongation. METHODS: Forty-one subjects with attention-deficit hyperactivity disorder were enrolled in this study. Participants were administered 40, 80, or 120 mg atomoxetine daily and were maintained on their respective dose for at least 2 weeks. We conducted electrocardiographic measurements and blood tests, measuring plasma atomoxetine concentrations after treatment. Electrocardiograms of 24 of the patients were also obtained before atomoxetine treatment. The QT interval was corrected using Bazett (QTcB) and Fridericia (QTcF) correction formulas. RESULTS: In these 24 patients, only the female patients had prolonged QTcB (P = 0.039) after atomoxetine treatment. There was no correlation between plasma atomoxetine concentrations and the corrected QT interval (QTc), or between atomoxetine dosage and the QTc. However, in female patients, there was a significant positive correlation between atomoxetine dosage and the QTcB (r = 0.631, P = 0.012), and there was a marginally significant positive correlation between atomoxetine dosage and the QTcF (r = 0.504, P = 0.055). In male patients, there was no correlation between atomoxetine dosage and the QTcB or QTcF intervals. There was no correlation between plasma atomoxetine concentrations and the QTc in either female or male patients. IMPLICATIONS: Clinicians should exhibit caution when prescribing atomoxetine, particularly for female patients.

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  • Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population. Reviewed International journal

    Yuto Takasaki, Takayoshi Koide, Chenyao Wang, Hiroki Kimura, Jingrui Xing, Itaru Kushima, Kanako Ishizuka, Daisuke Mori, Mariko Sekiguchi, Masashi Ikeda, Miki Aizawa, Naoko Tsurumaru, Yoshimi Iwayama, Akira Yoshimi, Yuko Arioka, Mami Yoshida, Hiromi Noma, Tomoko Oya-Ito, Yukako Nakamura, Shohko Kunimoto, Branko Aleksic, Yota Uno, Takashi Okada, Hiroshi Ujike, Jun Egawa, Hitoshi Kuwabara, Toshiyuki Someya, Takeo Yoshikawa, Nakao Iwata, Norio Ozaki

    Scientific reports   6   33311 - 33311   2016.9

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    N-methyl-d-aspartate receptors (NMDARs) play a critical role in excitatory synaptic transmission and plasticity in the central nervous systems. Recent genetics studies in schizophrenia (SCZ) show that SCZ is susceptible to NMDARs and the NMDAR signaling complex. In autism spectrum disorder (ASD), several studies report dysregulation of NMDARs as a risk factor for ASD. To further examine the association between NMDARs and SCZ/ASD development, we conducted a mutation screening study of GRIN2B which encodes NR2B subunit of NMDARs, to identify rare mutations that potentially cause diseases, in SCZ and ASD patients (n = 574 and 152, respectively). This was followed by an association study in a large sample set of SCZ, ASD, and normal healthy controls (n = 4145, 381, and 4432, respectively). We identified five rare missense mutations through the mutation screening of GRIN2B. Although no statistically significant association between any single mutation and SCZ or ASD was found, one of its variant, K1292R, is found only in the patient group. To further examine the association between mutations in GRIN2B and SCZ/ASD development, a larger sample size and functional experiments are needed.

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  • Rare UNC13B variations and risk of schizophrenia: Whole-exome sequencing in a multiplex family and follow-up resequencing and a case-control study. Reviewed International journal

    Jun Egawa, Satoshi Hoya, Yuichiro Watanabe, Ayako Nunokawa, Masako Shibuya, Masashi Ikeda, Emiko Inoue, Shujiro Okuda, Kenji Kondo, Takeo Saito, Naoshi Kaneko, Tatsuyuki Muratake, Hirofumi Igeta, Nakao Iwata, Toshiyuki Someya

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics   171 ( 6 )   797 - 805   2016.9

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    Rare genomic variations inherited in multiplex schizophrenia families are suggested to play a role in the genetic etiology of the disease. To identify rare variations with large effects on the risk of developing schizophrenia, we performed whole-exome sequencing (WES) in two affected and one unaffected individual of a multiplex family with 10 affected individuals. We also performed follow-up resequencing of the unc-13 homolog B (Caenorhabditis elegans) (UNC13B) gene, a potential risk gene identified by WES, in the multiplex family and undertook a case-control study to investigate association between UNC13B and schizophrenia. UNC13B coding regions (39 exons) from 15 individuals of the multiplex family and 111 affected offspring for whom parental DNA samples were available were resequenced. Rare missense UNC13B variations identified by resequencing were further tested for association with schizophrenia in two independent case-control populations comprising a total of 1,753 patients and 1,602 controls. A rare missense variation (V1525M) in UNC13B was identified by WES in the multiplex family; this variation was present in five of six affected individuals, but not in eight unaffected individuals or one individual of unknown disease status. Resequencing UNC13B coding regions identified five rare missense variations (T103M, M813T, P1349T, I1362T, and V1525M). In the case-control study, there was no significant association between rare missense UNC13B variations and schizophrenia, although single-variant meta-analysis indicated that M813T was nominally associated with schizophrenia. These results do not support a contribution of rare missense UNC13B variations to the genetic etiology of schizophrenia in the Japanese population. © 2016 Wiley Periodicals, Inc.

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  • Non-Linear Pharmacokinetics of Atomoxetine in Adult Japanese Patients With ADHD. Reviewed

    Sugimoto A, Suzuki Y, Orime N, Hayashi T, Egawa J, Sugai T, Inoue Y, Someya T

    Journal of attention disorders   2016.7

  • Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population. Reviewed International journal

    Yuichiro Watanabe, Ayako Nunokawa, Masako Shibuya, Masashi Ikeda, Akitoyo Hishimoto, Kenji Kondo, Jun Egawa, Naoshi Kaneko, Tatsuyuki Muratake, Takeo Saito, Satoshi Okazaki, Ayu Shimasaki, Hirofumi Igeta, Emiko Inoue, Satoshi Hoya, Takuro Sugai, Ichiro Sora, Nakao Iwata, Toshiyuki Someya

    Psychiatry research   235   13 - 8   2016.1

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    Rare inherited variations in multiplex families with schizophrenia are suggested to play a role in the genetic etiology of schizophrenia. To further investigate the role of rare inherited variations, we performed whole-exome sequencing (WES) in three families, each with two affected siblings. We also performed a three-stage follow-up case-control study in a Japanese population with a total of 2617 patients and 2396 controls. WES identified 15 rare truncating variations that were variously present in the two affected siblings in each family. These variations did not necessarily segregate with schizophrenia within families, and they were different in each family. In the follow-up study, four variations (NWD1 W169X, LCORL R7fsX53, CAMK2B L497fsX497, and C9orf89 Q102X) had a higher mutant allele frequency in patients compared with controls, although these associations were not significant in the combined population, which comprised the first-, second- and third-stage populations. These results do not support a contribution of the rare truncating variations identified in the three families to the genetic etiology of schizophrenia.

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  • Whole-exome sequencing in a family with a monozygotic twin pair concordant for autism spectrum disorder and a follow-up study. Reviewed International journal

    Jun Egawa, Yuichiro Watanabe, Atsunori Sugimoto, Ayako Nunokawa, Masako Shibuya, Hirofumi Igeta, Emiko Inoue, Satoshi Hoya, Naoki Orime, Taketsugu Hayashi, Toshiro Sugiyama, Toshiyuki Someya

    Psychiatry research   229 ( 1-2 )   599 - 601   2015.9

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    Two truncating variations (WDR90 V1125fs and EFCAB5 L1210fs), identified by whole-exome sequencing in a family with a monozygotic twin pair concordant for autism spectrum disorder (ASD), were not detected in 257 ASD patients, 677 schizophrenia patients or 667 controls in a follow-up study. Thus, these variations were exclusively identified in the family, suggesting that rare truncating variations may have a role in the genetic etiology of ASD, at least in a subset of ASD patients.

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  • Rare heterozygous truncating variations and risk of autism spectrum disorder: Whole-exome sequencing of a multiplex family and follow-up study in a Japanese population. Reviewed International journal

    Emiko Inoue, Yuichiro Watanabe, Jun Egawa, Atsunori Sugimoto, Ayako Nunokawa, Masako Shibuya, Hirofumi Igeta, Toshiyuki Someya

    Psychiatry and clinical neurosciences   69 ( 8 )   472 - 6   2015.8

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    AIMS: Rare heterozygous truncating variations in multiplex families with autism spectrum disorder (ASD) are suggested to play a major role in the genetic etiology of ASD. To further investigate the role of rare heterozygous truncating variations, we performed whole-exome sequencing (WES) in a multiplex ASD family with four affected individuals (two siblings and two maternal cousins), and a follow-up case-control study in a Japanese population. METHODS: WES was performed in four individuals (a proband, his affected and unaffected siblings, and their putative carrier mother) from the multiplex ASD family. Rare heterozygous truncating variations prioritized in WES were genotyped in 243 patients and 667 controls. RESULTS: By WES of the multiplex family, we prioritized two rare heterozygous truncating variations, RPS24 Q191X and CD300LF P261fsX266. However, we did not identify these variations in patients or controls in the follow-up study. CONCLUSIONS: Our findings suggest that two rare heterozygous truncating variations (RPS24 Q191X and CD300LF P261fsX266) are risk candidates for ASD.

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  • Developmental prosopagnosia referred to outpatient psychiatric service. Reviewed International journal

    Hideaki Kitamura, Jun Egawa, Toshiyuki Someya

    Psychiatry and clinical neurosciences   69 ( 4 )   238 - 238   2015.4

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  • Resequencing and association analysis of OXTR with autism spectrum disorder in a Japanese population. Reviewed International journal

    Jun Egawa, Yuichiro Watanabe, Masako Shibuya, Taro Endo, Atsunori Sugimoto, Hirofumi Igeta, Ayako Nunokawa, Emiko Inoue, Toshiyuki Someya

    Psychiatry and clinical neurosciences   69 ( 3 )   131 - 5   2015.3

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    AIMS: The oxytocin receptor (OXTR) is implicated in the pathophysiology of autism spectrum disorder (ASD). A recent study found a rare non-synonymous OXTR gene variation, rs35062132 (R376G), associated with ASD in a Japanese population. In order to investigate the association between rare non-synonymous OXTR variations and ASD, we resequenced OXTR and performed association analysis with ASD in a Japanese population. METHODS: We resequenced the OXTR coding region in 213 ASD patients. Rare non-synonymous OXTR variations detected by resequencing were genotyped in 213 patients and 667 controls. RESULTS: We detected three rare non-synonymous variations: rs35062132 (R376G/C), rs151257822 (G334D), and g.8809426G>T (R150S). However, there was no significant association between these rare non-synonymous variations and ASD. CONCLUSIONS: Our present study does not support the contribution of rare non-synonymous OXTR variations to ASD susceptibility in the Japanese population.

    DOI: 10.1111/pcn.12205

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  • Resequencing and Association Analysis of CLN8 with Autism Spectrum Disorder in a Japanese Population. Reviewed International journal

    Emiko Inoue, Yuichiro Watanabe, Jingrui Xing, Itaru Kushima, Jun Egawa, Shujiro Okuda, Satoshi Hoya, Takashi Okada, Yota Uno, Kanako Ishizuka, Atsunori Sugimoto, Hirofumi Igeta, Ayako Nunokawa, Toshiro Sugiyama, Norio Ozaki, Toshiyuki Someya

    PloS one   10 ( 12 )   e0144624   2015

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    Rare variations contribute substantially to autism spectrum disorder (ASD) liability. We recently performed whole-exome sequencing in two families with affected siblings and then carried out a follow-up study and identified ceroid-lipofuscinosis neuronal 8 (epilepsy, progressive with mental retardation) (CLN8) as a potential genetic risk factor for ASD. To further investigate the role of CLN8 in the genetic etiology of ASD, we performed resequencing and association analysis of CLN8 with ASD in a Japanese population. Resequencing the CLN8 coding region in 256 ASD patients identified five rare missense variations: g.1719291G>A (R24H), rs201670636 (F39L), rs116605307 (R97H), rs143701028 (T108M) and rs138581191 (N152S). These variations were genotyped in 568 patients (including the resequenced 256 patients) and 1017 controls. However, no significant association between these variations and ASD was identified. This study does not support a contribution of rare missense CLN8 variations to ASD susceptibility in the Japanese population.

    DOI: 10.1371/journal.pone.0144624

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  • Novel rare missense variations and risk of autism spectrum disorder: whole-exome sequencing in two families with affected siblings and a two-stage follow-up study in a Japanese population. Reviewed International journal

    Jun Egawa, Yuichiro Watanabe, Chenyao Wang, Emiko Inoue, Atsunori Sugimoto, Toshiro Sugiyama, Hirofumi Igeta, Ayako Nunokawa, Masako Shibuya, Itaru Kushima, Naoki Orime, Taketsugu Hayashi, Takashi Okada, Yota Uno, Norio Ozaki, Toshiyuki Someya

    PloS one   10 ( 3 )   e0119413   2015

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    Rare inherited variations in multiplex families with autism spectrum disorder (ASD) are suggested to play a major role in the genetic etiology of ASD. To further investigate the role of rare inherited variations, we performed whole-exome sequencing (WES) in two families, each with three affected siblings. We also performed a two-stage follow-up case-control study in a Japanese population. WES of the six affected siblings identified six novel rare missense variations. Among these variations, CLN8 R24H was inherited in one family by three affected siblings from an affected father and thus co-segregated with ASD. In the first stage of the follow-up study, we genotyped the six novel rare missense variations identified by WES in 241 patients and 667 controls (the Niigata sample). Only CLN8 R24H had higher mutant allele frequencies in patients (1/482) compared with controls (1/1334). In the second stage, this variation was further genotyped, yet was not detected in a sample of 309 patients and 350 controls (the Nagoya sample). In the combined Niigata and Nagoya samples, there was no significant association (odds ratio = 1.8, 95% confidence interval = 0.1-29.6). These results suggest that CLN8 R24H plays a role in the genetic etiology of ASD, at least in a subset of ASD patients.

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  • A rare MIR138-2 gene variation is associated with schizophrenia in a Japanese population. Reviewed International journal

    Yuichiro Watanabe, Masako Shibuya, Ayako Nunokawa, Naoshi Kaneko, Hirofumi Igeta, Jun Egawa, Toshiyuki Someya, Akitoyo Hishimoto, Kentaro Mouri, Ichiro Sora

    Psychiatry research   215 ( 3 )   801 - 2   2014.3

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    DOI: 10.1016/j.psychres.2013.12.029

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  • Interleukin 1 beta gene and risk of schizophrenia: detailed case-control and family-based studies and an updated meta-analysis Reviewed

    Masako Shibuya, Yuichiro Watanabe, Ayako Nunokawa, Jun Egawa, Naoshi Kaneko, Hirofumi Igeta, Toshiyuki Someya

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   29 ( 1 )   31 - 37   2014.1

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    ObjectiveInterleukin-1 beta (IL-1) has been implicated in the pathophysiology of schizophrenia. To assess whether the IL1B gene confers increased susceptibility to schizophrenia, we conducted case-control and family-based studies and an updated meta-analysis.
    MethodsWe tested the association between IL1B and schizophrenia in 1229 case-control and 112 trio samples using 12 markers, including common tagging single nucleotide variations (SNVs) and a rare non-synonymous variation detected by resequencing the coding regions. We also performed a meta-analysis of rs16944 using a total of 8724 case-control and 201 trio samples from 16 independent populations.
    ResultsWe found no significant associations between any of the 12 SNVs examined and schizophrenia in either case-control or trio samples. Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia.
    ConclusionsThe present study does not support a role for IL1B in schizophrenia susceptibility. Copyright (c) 2013 John Wiley & Sons, Ltd.

    DOI: 10.1002/hup.2365

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  • Possible association between the oxytocin receptor gene and N-acetylaspartate of the right medial temporal lobe in autism spectrum disorders Reviewed

    Jun Egawa, Yuichiro Watanabe, Taro Endo, Hideaki Kitamura, Toshiyuki Someya

    Psychiatry and Clinical Neurosciences   68 ( 1 )   83   2014.1

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  • Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia. Reviewed International journal

    Yuichiro Watanabe, Yoshimi Iijima, Jun Egawa, Ayako Nunokawa, Naoshi Kaneko, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Masanari Itokawa, Tsukasa Sasaki, Norio Ozaki, Ryota Hashimoto, Masako Shibuya, Hirofumi Igeta, Toshiyuki Someya

    Schizophrenia research   150 ( 2-3 )   596 - 7   2013.11

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  • Association of rs2129575 in the tryptophan hydroxylase 2 gene with clinical phenotypes of autism spectrum disorders Reviewed

    Jun Egawa, Yuichiro Watanabe, Taro Endo, Toshiyuki Someya

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   67 ( 6 )   457 - 458   2013.9

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    DOI: 10.1111/pcn.12080

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  • Neural activity in the posterior superior temporal region during eye contact perception correlates with autistic traits Reviewed

    Naoya Hasegawa, Hideaki Kitamura, Hiroatsu Murakami, Shigeki Kameyama, Mutsuo Sasagawa, Jun Egawa, Taro Endo, Toshiyuki Someya

    NEUROSCIENCE LETTERS   549   45 - 50   2013.8

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    The present study investigated the relationship between neural activity associated with gaze processing and autistic traits in typically developed subjects using magnetoencephalography. Autistic traits in 24 typically developed college students with normal intelligence were assessed using the Autism Spectrum Quotient (AQ). The Minimum Current Estimates method was applied to estimate the cortical sources of magnetic responses to gaze stimuli. These stimuli consisted of apparent motion of the eyes, displaying direct or averted gaze motion. Results revealed gaze-related brain activations in the 150-250 ms time window in the right posterior superior temporal sulcus (pSTS), and in the 150-450 ms time window in medial prefrontal regions. In addition, the mean amplitude in the 150-250 ms time window in the right pSTS region was modulated by gaze direction, and its activity in response to direct gaze stimuli correlated with AQ score. pSTS activation in response to direct gaze is thought to be related to higher-order social processes. Thus, these results suggest that brain activity linking eye contact and social signals is associated with autistic traits in a typical population. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.neulet.2013.05.067

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  • Association between OXTR and clinical phenotypes of autism spectrum disorders Reviewed

    Jun Egawa, Yuichiro Watanabe, Taro Endo, Ryu Tamura, Toshiyuki Someya, Yuichiro Watanabe, Naio Masuzawa

    PSYCHIATRY RESEARCH   208 ( 1 )   99 - 100   2013.6

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    DOI: 10.1016/j.psychres.2012.11.007

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  • Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population Reviewed

    Jun Egawa, Ayako Nunokawa, Masako Shibuya, Yuichiro Watanabe, Naoshi Kaneko, Hirofumi Igeta, Toshiyuki Someya

    Psychiatry and Clinical Neurosciences   67 ( 4 )   277 - 279   2013.5

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    MicroRNA may play a role in the pathophysiology of schizophrenia. A recent meta-analysis of genome-wide association studies indicated a significant association between schizophrenia and a common intronic variation in MIR137HG (microRNA 137 host gene) encoding the primary microRNA-137. To explore additional risk variations for schizophrenia, we resequenced MIR137 and performed an association analysis in 1321 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. There were no significant associations between these variations and schizophrenia. Our resequencing and association analysis of MIR137 failed to find additional risk variations for schizophrenia. © 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology.

    DOI: 10.1111/pcn.12047

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  • Altered Activity of the Primary Visual Area during Gaze Processing in Individuals with High-Functioning Autistic Spectrum Disorder: A Magnetoencephalography Study Reviewed

    Naoya Hasegawa, Hideaki Kitamura, Hiroatsu Murakami, Shigeki Kameyama, Mutsuo Sasagawa, Jun Egawa, Ryu Tamura, Taro Endo, Toshiyuki Someya

    NEUROPSYCHOBIOLOGY   68 ( 3 )   181 - 188   2013

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    Background: Individuals with autistic spectrum disorder (ASD) demonstrate an impaired ability to infer the mental states of others from their gaze. Thus, investigating the relationship between ASD and eye gaze processing is crucial for understanding the neural basis of social impairments seen in individuals with ASD. In addition, characteristics of ASD are observed in more comprehensive visual perception tasks. These visual characteristics of ASD have been well-explained in terms of the atypical relationship between high- and low-level gaze processing in ASD. Method: We studied neural activity during gaze processing in individuals with ASD using magnetoencephalography, with a focus on the relationship between high- and low-level gaze processing both temporally and spatially. Minimum Current Estimate analysis was applied to perform source analysis of magnetic responses to gaze stimuli. Results: The source analysis showed that later activity in the primary visual area (V1) was affected by gaze direction only in the ASD group. Conversely, the right posterior superior temporal sulcus, which is a brain region that processes gaze as a social signal, in the typically developed group showed a tendency toward greater activation during direct compared with averted gaze processing. Conclusion: These results suggest that later activity in V1 relating to gaze processing is altered or possibly enhanced in high-functioning individuals with ASD, which may underpin the social cognitive impairments in these individuals. (C) 2013 S. Karger AG, Basel

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  • Oxytocin receptor (OXTR) gene and risk of schizophrenia: Case-control and family-based analyses and meta-analysis in a Japanese population Reviewed

    Yuichiro Watanabe, Naoshi Kaneko, Ayako Nunokawa, Masako Shibuya, Jun Egawa, Toshiyuki Someya

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   66 ( 7 )   622 - 622   2012.12

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    DOI: 10.1111/j.1440-1819.2012.02396.x

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  • Supportive evidence for the association between the Gln2Pro polymorphism in the SIGMAR1 gene and schizophrenia in the Japanese population: A case-control study and an updated meta-analysis Reviewed

    Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Masako Shibuya, Jun Egawa, Toshiyuki Someya

    SCHIZOPHRENIA RESEARCH   141 ( 2-3 )   279 - 280   2012.11

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    DOI: 10.1016/j.schres.2012.06.043

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  • Influence of the 5-HTR1A C-1019G polymorphism on clinical phenotypes of autism spectrum disorders Reviewed

    Jun Egawa, Taro Endo, Ryu Tamura, Naio Masuzawa, Naoki Fukui, Takuro Sugai, Toshiyuki Someya

    PSYCHIATRY RESEARCH   198 ( 2 )   336 - 337   2012.7

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    DOI: 10.1016/j.psychres.2012.02.025

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  • A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population Reviewed

    Yuichiro Watanabe, Jun Egawa, Yoshimi Iijima, Ayako Nunokawa, Naoshi Kaneko, Masako Shibuya, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Mamoru Tochigi, Hiroshi Kunugi, Masanari Itokawa, Norio Ozaki, Ryota Hashimoto, Toshiyuki Someya

    SCHIZOPHRENIA RESEARCH   137 ( 1-3 )   264 - 266   2012.5

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    DOI: 10.1016/j.schres.2012.01.034

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  • A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population Reviewed

    Jun Egawa, Yuichiro Watanabe, Ayako Nunokawa, Taro Endo, Naoshi Kaneko, Ryu Tamura, Toshiro Sugiyama, Toshiyuki Someya

    PSYCHIATRY RESEARCH   196 ( 2-3 )   320 - 322   2012.4

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    We conducted a detailed association analysis between the tryptophan hydroxylase 2 gene and autism spectrum disorders in a Japanese population using 19 markers, including tagging single nucleotide polymorphisms and a novel missense variation, p.R225Q identified through exon resequencing. However, we failed to obtain supportive evidence for an association. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.psychres.2011.09.001

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  • Reduced thalamus volume in non-right-handed male patients with autism spectrum disorders Reviewed

    Jun Egawa, Yuichiro Watanabe, Hideaki Kitamura, Taro Endo, Ryu Tamura, Naoya Hasegawa, Toshiyuki Someya

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   65 ( 4 )   395 - 395   2011

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    DOI: 10.1111/j.1440-1819.2011.02210.x

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  • 5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder. Reviewed

    Endo T, Kitamura H, Tamura R, Egawa J, Sugai T, Fukui N, Suzuki Y, Someya T

    Psychiatry research   183 ( 2 )   170 - 173   2010.8

  • 5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder Reviewed

    Taro Endo, Hideaki Kitamura, Ryu Tamura, Jun Egawa, Takuro Sugai, Naoki Fukui, Yutaro Suzuki, Toshiyuki Someya

    PSYCHIATRY RESEARCH-NEUROIMAGING   183 ( 2 )   170 - 173   2010.8

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    We investigated whether the promoter region of the serotonin transporter gene (5-HTTLPR) polymorphism influenced neurochemical metabolism in 26 individuals with autism spectrum disorder. Individuals with the S/S genotype of the 5-HTTLPR polymorphism showed significantly lower levels of N-acetylaspartate/creatine in the right medial prefrontal cortex compared with those with the S/L genotype. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.pscychresns.2010.04.015

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  • Elucidation of system brain function improvement mechanism by group therapy for internet gaming disorder-Establishment of an experimental system using magnetoencephalography (MEG)-

    杉本篤言, 杉本篤言, 山田千沙, 吉永清宏, 村松優希, 江川純, 飯島淳彦, 飯島淳彦, 飯島淳彦, 染矢俊幸

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    杉本 篤言, 吉永 清宏, 林 剛丞, 江川 純, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   122回   64 - 64   2019.11

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  • 児童・思春期精神科病棟でのゲーム機使用に関する全国調査

    吉永 清宏, 杉本 篤言, 姉崎 則子, 佐藤 博幸, 山本 万里子, 山田 美穂, 江川 純, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S759 - S759   2019.6

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  • 自閉症リスク遺伝子Neuroligin3の機能的リン酸化部位の機能解析

    江川 純, 五十嵐 道弘, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S655 - S655   2019.6

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  • 妊産婦の発達特性が子へのボンディングに与える影響について

    坪谷 隆介, 茂木 崇治, 福井 直樹, 橋尻 洸陽, 須貝 拓朗, 江川 純, 三留 節子, 荒木 理恵, 池 睦美, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S641 - S641   2019.6

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  • 周産期の不安・抑うつがボンディングに与える影響について

    橋尻 洸陽, 茂木 崇治, 福井 直樹, 坪谷 隆介, 須貝 拓朗, 江川 純, 三留 節子, 荒木 理恵, 池 睦美, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S640 - S640   2019.6

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  • DSM-5診断における自閉症スペクトラム指数日本語版(AQ-J)の有用性について

    吉永 清宏, 江川 純, 林 剛丞, 杉本 篤言, 新藤 雅延, 橘 輝, 北村 秀明, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S639 - S639   2019.6

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  • 成人患者の課題遂行中の前頭前皮質活動性とADHD症状の関連

    杉本 篤言, 鈴木 雄太郎, 吉永 清宏, 折目 直樹, 林 剛丞, 小野 信, 須貝 拓朗, 江川 純, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S639 - S639   2019.6

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  • 自閉スペクトラム症罹患同胞対3ペアのエクソーム解析

    澁谷 雅子, 渡部 雄一郎, 保谷 智史, 森川 亮, 江川 純, 杉本 篤言, 井桁 裕文, 林 剛丞, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S637 - S637   2019.6

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  • 小児ADHD患者におけるアトモキセチン投与量と血中濃度の関係性

    吉永 清宏, 杉本 篤言, 鈴木 雄太郎, 折目 直樹, 林 剛丞, 小野 信, 須貝 拓朗, 江川 純, 井上 義政, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S637 - S637   2019.6

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  • 統合失調症患者におけるSETD1A遺伝子のシーケンス

    森川 亮, 井桁 裕文, 渡部 雄一郎, 保谷 智史, 澁谷 雅子, 江川 純, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S615 - S615   2019.6

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  • マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

    林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019.6

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  • 自閉スペクトラム指数(Autism-Spectrum Quotient)日本語版の因子構造について

    福井 直樹, 茂木 崇治, 橋尻 洸陽, 坪谷 陽介, 須貝 拓朗, 江川 純, 三留 節子, 荒木 理恵, 池 睦美, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S771 - S771   2019.6

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  • 分娩歴と完全母乳栄養が妊産婦の不安・抑うつに与える影響について

    福井 直樹, 茂木 崇治, 橋尻 洸陽, 坪谷 隆介, 須貝 拓朗, 江川 純, 三留 節子, 荒木 理恵, 池 睦美, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S771 - S771   2019.6

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  • 周産期のメンタルヘルスに影響を与える因子についての検討

    茂木 崇治, 福井 直樹, 橋尻 洸陽, 坪谷 隆介, 須貝 拓朗, 江川 純, 三留 節子, 荒木 理恵, 池 睦美, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S771 - S771   2019.6

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  • Mother-to-Infant Bonding Scale(MIBS)日本語版(MIBS-J)の因子構造についての検討

    茂木 崇治, 福井 直樹, 橋尻 洸陽, 坪谷 隆介, 須貝 拓朗, 江川 純, 三留 節子, 荒木 理恵, 池 睦美, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S771 - S771   2019.6

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  • 拡散テンソル画像を用いた脳機能結合と自閉スペクトラム症との関連解析

    江川 純, 杉本 篤言, 吉永 清宏, 林 剛丞, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S763 - S763   2019.6

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  • アトモキセチン血中濃度と副作用の関連性

    杉本 篤言, 須貝 拓朗, 鈴木 雄太郎, 折目 直樹, 林 剛丞, 吉永 清宏, 江川 純, 小野 信, 井上 義政, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S760 - S760   2019.6

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  • 成人患者の課題遂行中の前頭前皮質活動性とADHD症状の関連性、およびそのatomoxetineによる変化

    杉本 篤言, 鈴木 雄太郎, 吉永 清宏, 折目 直樹, 林 剛丞, 江川 純, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   59回   O1 - 1   2018.10

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  • 妊産婦における発達特性と不安・抑うつとの関連について

    茂木 崇治, 福井 直樹, 須貝 拓朗, 江川 純, 橋尻 洸陽, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2018特別号 )   S669 - S669   2018.6

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  • 妊産婦の不安・抑うつと子との間のアタッチメントとの関連について

    福井 直樹, 茂木 崇治, 須貝 拓朗, 江川 純, 橋尻 洸陽, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2018特別号 )   S670 - S670   2018.6

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  • 妊産婦の発達特性と子との間のアタッチメントとの関連について

    茂木 崇治, 福井 直樹, 須貝 拓朗, 江川 純, 橋尻 洸陽, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    精神神経学雑誌   ( 2018特別号 )   S669 - S669   2018.6

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  • 5 母親の不安・抑うつと母子間のアタッチメントに関する周産期メンタルヘルス研究 (Ⅰ.一般演題, 第29回新潟周産母子研究会)

    福井 直樹, 茂木 崇治, 橋尻 洸陽, 須貝 拓朗, 江川 純, 三留 節子, 池 睦美, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之, 染矢 俊幸

    新潟医学会雑誌   131 ( 12 )   720 - 720   2017.12

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  • 小児ADHD患者におけるatomoxetine血中濃度と臨床効果の関係

    杉本 篤言, 鈴木 雄太郎, 折目 直樹, 林 剛丞, 吉永 清宏, 江川 純, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   58回   133 - 133   2017.10

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  • 入院治療を行いチック症状が著明に改善したトゥレット症の1例

    吉永 清宏, 杉本 篤言, 折目 直樹, 松崎 陽子, 林 剛丞, 江川 純, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   58回   263 - 263   2017.10

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  • PDCD11遺伝子の稀な変異と統合失調症の発症リスク 罹患同胞対家系の全エクソーム解析、ターゲットリシーケンス、および症例・対照研究

    保谷 智史, 渡部 雄一郎, 菱本 明豊, 布川 綾子, 金子 尚史, 村竹 辰之, 新名 尚史, 大塚 郁夫, 奥田 修二郎, 井上 絵美子, 井桁 裕文, 澁谷 雅子, 江川 純, 折目 直樹, 曽良 一郎, 染矢 俊幸

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   177 - 177   2017.9

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  • SETD1A遺伝子の稀な変異と統合失調症の発症リスク

    渡部 雄一郎, 井桁 裕文, 保谷 智史, 布川 綾子, 井上 絵美子, 江川 純, 澁谷 雅子, 染矢 俊幸

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   189 - 189   2017.9

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  • はとこ婚の両親を持つ統合失調症罹患同胞家系のエクソーム解析

    井桁 裕文, 渡部 雄一郎, 布川 綾子, 井上 絵美子, 保谷 智史, 澁谷 雅子, 江川 純, 染矢 俊幸

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   189 - 189   2017.9

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  • FBXO18遺伝子の稀な変異と統合失調症のリスク

    布川 綾子, 保谷 智史, 渡部 雄一郎, 井上 絵美子, 井桁 裕文, 澁谷 雅子, 江川 純, 染矢 俊幸

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   179 - 179   2017.9

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  • Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders

    Ishizuka K, Fujita Y, Kawabata T, Kimura H, Iwayama Y, Inada T, Okahisa Y, Egawa J, Usami M, Kushima I, Uno Y, Okada T, Ikeda M, Aleksic B, Mori D, Someya To, Yoshikawa T, Iwata N, Nakamura H, Yamashita T, Ozaki N

    TRANSLATIONAL PSYCHIATRY   7 ( 8 )   e1184 - e1184   2017.8

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/tp.2017.173

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    Other Link: http://www.nature.com/articles/tp2017173

  • 本邦における統合失調症と自閉スペクトラム症に関連するGRIN2Bの遺伝子変異の探索

    高崎 悠登, 尾崎 紀夫, 小出 隆義, 王 晨堯, 木村 大樹, 久島 周, 石塚 佳奈子, 森 大輔, 池田 匡志, アレクシッチ・ブランコ, 岡田 俊, 江川 純, 桑原 斉, 染矢 俊幸, 吉川 武男, 岩田 仲生

    精神神経学雑誌   ( 2017特別号 )   S626 - S626   2017.6

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  • 本邦における統合失調症と自閉スペクトラム症に関連するGRIN2Bの遺伝子変異の探索

    高崎 悠登, 尾崎 紀夫, 小出 隆義, 王 晨堯, 木村 大樹, 久島 周, 石塚 佳奈子, 森 大輔, 池田 匡志, アレクシッチ・ブランコ, 岡田 俊, 江川 純, 桑原 斉, 染矢 俊幸, 吉川 武男, 岩田 仲生

    精神神経学雑誌   ( 2017特別号 )   S626 - S626   2017.6

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  • 自閉スペクトラム症多発罹患家系の全エクソームシークエンスおよびフォローアップ研究

    井上 絵美子, 渡部 雄一郎, 江川 純, 杉本 篤言, 布川 綾子, 澁谷 雅子, 井桁 裕文, 染矢 俊幸

    精神神経学雑誌   119 ( 1 )   3 - 8   2017.1

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    自閉スペクトラム症の多発罹患家系において,稀な変異が発症に重要な役割を果たすことが示唆されている.自閉スペクトラム症の稀なリスク変異を同定するため,われわれは4人の罹患者(同胞2人,母方いとこ2人)を有する多発罹患家系の全エクソームシークエンスおよび症例・対照サンプル(243対667)を用いたフォローアップ研究を実施した.多発罹患家系の4人(発端者,罹患同胞,非罹患同胞,保因者と推定される母)について全エクソームシークエンスを行ったところ,2つの稀な短縮型変異(RPS24遺伝子Q191X変異とCD300LF遺伝子P261fsX266変異)を同定した.これらの変異は,フォローアップ研究の910サンプルでは検出されなかった.本研究により,2つの稀な短縮型変異(RPS24遺伝子Q191X変異とCD300LF遺伝子P261fsX266変異)が自閉スペクトラム症の候補リスク変異であることが示唆された.(著者抄録)

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  • 視線・矢印による注意喚起が眼球運動に及ぼす影響

    吉井 大基, 江川 純, 染矢 俊幸, 飯島 淳彦

    Vision   29 ( 1 )   36 - 36   2017.1

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  • そこが知りたい薬物療法Q&A 自閉スペクトラム症の易刺激性に対するrisperidoneの有効性、安全性について知りたい

    大竹 裕美, 小野 信, 江川 純, 染矢 俊幸

    臨床精神薬理   19 ( 11 )   1615 - 1618   2016.11

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  • 児童精神科病棟退院後の児の自傷関連行動に関する研究

    杉本 篤言, 鈴木 雄太郎, 吉永 清宏, 折目 直樹, 林 剛丞, 松崎 陽子, 江川 純, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   57回   113 - 113   2016.10

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  • 児童精神科病棟入院中の試験登校の成否と退院後の不登校再発の関係について

    吉永 清宏, 杉本 篤言, 折目 直樹, 松崎 陽子, 林 剛丞, 江川 純, 鈴木 雄太郎, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   57回   196 - 196   2016.10

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  • 成人ADHD患者においてatomoxetine血中濃度や用量が心電図QT間隔に与える影響

    田尻 美寿々, 鈴木 雄太郎, 杉本 篤言, 折目 直樹, 林 剛丞, 江川 純, 須貝 拓朗, 井上 義政, 染矢 俊幸

    精神神経学雑誌   ( 2016特別号 )   S373 - S373   2016.6

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  • 【発達障害とトラウマ】 発達障害とトラウマの遺伝学 遺伝と環境をつなぐエピジェネティクス

    江川 純

    発達障害医学の進歩   ( 28 )   45 - 51   2016.4

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  • 自閉スペクトラム症多発罹患家系のエクソーム解析を起点としたリスク遺伝子の追究

    井上 絵美子, 江川 純, 渡部 雄一郎, 染矢 俊幸

    新潟県医師会報   ( 790 )   10 - 11   2016.1

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  • 【発達障害とストレス】 ストレス関連障害を示す発達障害

    林 剛丞, 江川 純, 染矢 俊幸

    ストレス科学研究   30   10 - 15   2015.11

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    DOI: 10.5058/stresskagakukenkyu.30.10

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  • 統合失調症多発罹患家系のエクソーム解析

    渡部 雄一郎, 江川 純, 澁谷 雅子, 布川 綾子, 金子 尚史, 村竹 辰之, 井桁 裕文, 井上 絵美子, 保谷 智史, 染矢 俊幸

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   37回・45回   192 - 192   2015.9

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  • 自閉スペクトラム症多発罹患家系の全エクソームシーケンスおよびフォローアップ研究

    井上 絵美子, 渡部 雄一郎, 江川 純, 杉本 篤言, 布川 綾子, 澁谷 雅子, 井桁 裕文, 染矢 俊幸

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   37回・45回   209 - 209   2015.9

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  • 自閉スペクトラム症罹患同胞2家系のエクソーム解析および2段階フォローアップ解析

    江川 純, 渡部 雄一郎, 王 晨堯, 井上 絵美子, 杉本 篤言, 杉山 登志郎, 井桁 裕文, 布川 綾子, 澁谷 雅子, 久島 周, 折目 直樹, 林 剛丞, 岡田 俊, 宇野 洋太, 尾崎 紀夫, 染矢 俊幸

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   37回・45回   209 - 209   2015.9

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  • 「発達」からみたこころの臨床 脳とこころにおけるエピジェネティックス

    江川 純

    こころの科学   ( 181 )   21 - 25   2015.5

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  • Prenatal exposure to 1-bromopropane suppresses kainate-induced wet dog shakes in immature rats

    Yukiko Fueta, Masanari Kanemitsu, Sumie Egawa, Toru Ishidao, Susumu Ueno, Hajime Hori

    Journal of UOEH   37 ( 4 )   255 - 261   2015

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    1-Bromopropane (1-BP) is used in degreasing solvents and spray adhesives. The adverse effects of 1-BP have been reported in human cases and adult animal models, and its developmental toxicity has also been reported, but its effects on developmental neurotoxicity have not been investigated in detail. We evaluated the effects in rat pups of prenatal exposure to 1-BP on behaviors such as scratching and wet dog shakes (WDS), which were induced by injection of kainate (KA). Pregnant Wistar rats were exposed to vaporized 1-BP with 700 ppm from gestation day 1 to day 20 (6 h/day). KA at doses of 0.1, 0.5, and 2.0 mg/kg were intraperitoneally injected into a control group and a 1-BP-exposed group of pups on postnatal day 14. There was no significant difference in scratching between the control and the prenatally 1-BP-exposed groups, while suppression of the occurrence ratio of WDS was observed at the low dose of 0.1 mg/kg of KA in the prenatally 1-BP-exposed pups. Our results suggest that prenatal exposure to 1-BP affects neurobehavioral responses in the juvenile period.

    DOI: 10.7888/juoeh.37.255

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  • 児童・青年期における精神科薬物療法の問題 小児への向精神薬投与によるQT延長のリスクについて

    杉本 篤言, 鈴木 雄太郎, 折目 直樹, 林 剛丞, 江川 純, 小野 信, 須貝 拓朗, 染矢 俊幸

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   24回・44回   93 - 93   2014.11

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  • 小児において向精神薬がQT間隔に与える影響

    折目 直樹, 鈴木 雄太郎, 杉本 篤言, 林 剛丞, 江川 純, 須貝 拓朗, 染矢 俊幸

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   24回・44回   186 - 186   2014.11

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  • 小児および成人においてatomoxetineが心電図パラメーターに及ぼす影響について

    杉本 篤言, 鈴木 雄太郎, 林 剛丞, 折目 直樹, 江川 純, 遠藤 太郎, 須貝 拓朗, 染矢 俊幸

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   24回・44回   163 - 163   2014.11

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  • 【発達障害ベストプラクティス-子どもから大人まで-】 (第III部)各論 ADHD ADHDの評価尺度

    折目 直樹, 江川 純, 染矢 俊幸

    精神科治療学   29 ( 増刊 )   313 - 317   2014.10

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  • 虐待の重症度および解離関連症状がアトモキセチン効果に及ぼす影響についての検討

    杉本 篤言, 鈴木 雄太郎, 林 剛丞, 折目 直樹, 江川 純, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   55回   143 - 143   2014.10

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  • アトモキセチンの効果予測因子についての検討

    林 剛丞, 杉本 篤言, 鈴木 雄太郎, 折目 直樹, 江川 純, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   55回   142 - 142   2014.10

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  • 自閉症スペクトラム障害におけるオキシトシン受容体遺伝子のエクソンリシーケンスおよび関連解析

    江川 純, 杉本 篤言, 遠藤 太郎, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   55回   237 - 237   2014.10

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  • 小児自閉症評定尺度東京版(CARS-TV)の因子構造

    折目 直樹, 江川 純, 杉本 篤言, 林 剛丞, 遠藤 太郎, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   55回   283 - 283   2014.10

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  • 注意欠如・多動性障害児の視覚性持続注意課題における反応時間の検討

    杉本 篤言, 江川 純, 林 剛丞, 折目 直樹, 遠藤 太郎, 染矢 俊幸

    小児の精神と神経   54 ( 1 )   75 - 76   2014.4

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  • 開放病棟における薬剤業務事故0を目指して

    荒木 舞美, 吉田 祥子, 江川 純二, 石田 陽子, 大迫 弘隆, 土田 千賀

    新田塚医療福祉センター雑誌   10   65 - 68   2013.12

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  • 注意欠如・多動性障害児の視覚性持続注意課題における反応時間の検討

    杉本 篤言, 江川 純, 林 剛丞, 折目 直樹, 遠藤 太郎, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   110回   42 - 42   2013.11

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  • 注意欠如・多動性障害の症状評価における多チャネル近赤外線スペクトロスコピーの有用性についての検討

    杉本 篤言, 林 剛丞, 折目 直樹, 江川 純, 遠藤 太郎, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   54回   247 - 247   2013.10

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  • トリプトファン水酸化酵素2遺伝子多型rs2129575の自閉症スペクトラム障害の臨床表現型への影響について

    林 剛丞, 江川 純, 遠藤 太郎, 田村 立, 杉本 篤言, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   54回   396 - 396   2013.10

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  • 自閉症スペクトラム障害におけるオキシトシン受容体遺伝子と右内側側頭葉N-アセチルアスパラギン酸との関連研究

    江川 純, 遠藤 太郎, 杉本 篤言, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   54回   316 - 316   2013.10

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  • アトモキセチンによる前頭前野皮質血流への影響の検討

    折目 直樹, 杉本 篤言, 林 剛丞, 江川 純, 遠藤 太郎, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   54回   250 - 250   2013.10

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  • 注意欠如・多動性障害に対するatomoxetine投与が心電図に及ぼす影響について

    杉本 篤言, 鈴木 雄太郎, 林 剛丞, 折目 直樹, 江川 純, 遠藤 太郎, 染矢 俊幸

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   23回・43回   177 - 177   2013.10

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  • 新潟県新潟市就学前検診における広汎性発達障害の実態調査

    林 剛丞, 遠藤 太郎, 田村 立, 江川 純, 杉本 篤言, 折目 直樹, 染矢 俊幸

    小児の精神と神経   53 ( 1 )   88 - 89   2013.4

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  • アトモキセチン投与後に近赤外線スペクトロスコピー検査による右前頭葉脳血流の改善を認めた注意欠如・多動性障害の一例

    杉本 篤言, 遠藤 太郎, 林 剛丞, 折目 直樹, 江川 純, 橘 輝, 染矢 俊幸

    小児の精神と神経   53 ( 1 )   85 - 86   2013.4

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  • ADHDの認知機能と併存障害および環境因子との関連について

    折目 直樹, 遠藤 太郎, 橘 輝, 杉本 篤言, 林 剛丞, 江川 純, 田村 立, 染矢 俊幸

    小児の精神と神経   53 ( 1 )   83 - 84   2013.4

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  • セロトニン受容体1A遺伝子多型の自閉症スペクトラム障害における臨床表現型への影響

    江川 純, 遠藤 太郎, 田村 立, 杉本 篤言, 増澤 菜生, 染矢 俊幸

    小児の精神と神経   53 ( 1 )   60 - 61   2013.4

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  • 新潟県新潟市就学前検診における広汎性発達障害の実態調査

    林 剛丞, 遠藤 太郎, 田村 立, 江川 純, 杉本 篤言, 折目 直樹, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   108回   66 - 66   2012.11

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  • セロトニン受容体1A遺伝子多型の自閉症スペクトラム障害における臨床表現型への影響

    江川 純, 遠藤 太郎, 田村 立, 杉本 篤言, 増澤 菜生, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   108回   49 - 49   2012.11

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  • アトモキセチン投与後に近赤外線スペクトロスコピー検査による右前頭葉脳血流の改善を認めた注意欠如・多動性障害の一例

    杉本 篤言, 遠藤 太郎, 林 剛丞, 折目 直樹, 江川 純, 橘 輝, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   108回   64 - 64   2012.11

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  • ADHDの認知機能と併存障害および環境因子との関連について

    折目 直樹, 遠藤 太郎, 橘 輝, 杉本 篤言, 林 剛丞, 江川 純, 田村 立, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   108回   63 - 63   2012.11

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  • Case-control study and meta-analysis did not confirm an association between DRD2 Ser311Cys and schizophrenia in the Japanese

    Y. Watanabe, A. Nunokawa, N. Kaneko, M. Shibuya, J. Egawa, N. Fukui, H. Igeta, T. Someya

    JOURNAL OF NEUROCHEMISTRY   123   75 - 75   2012.10

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    Web of Science

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  • Rare missense variations of TPH2 and risk of autism: Exon resequensing and association analysis

    J. Egawa, Y. Watanabe, A. Nunokawa, T. Endo, N. Kaneko, R. Tamura, T. Sugiyama, T. Someya

    JOURNAL OF NEUROCHEMISTRY   123   69 - 69   2012.10

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  • 授乳期ラットのscratching及びwet-dog shakeの行動発現に対する1-ブロモプロパン胎生期曝露の影響

    金光 雅成, 笛田 由紀子, 江川 純恵, 石田尾 徹, 上野 晋, 保利 一

    産業衛生学雑誌   54 ( 臨増 )   390 - 390   2012.5

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  • Case-control study and meta-analysis of Ser311Cys polymorphism in the DRD2 gene demonstrate lack of association with risk for schizophrenia in the Japanese population

    Y. Watanabe, A. Nunokawa, N. Kaneko, M. Shibuya, J. Egawa, N. Fukui, T. Someya

    GENETICS AND MOLECULAR RESEARCH   11 ( 2 )   1142 - 1145   2012

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    DOI: 10.4238/2012.April.27.13

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  • 新潟県阿賀野市における広汎性発達障害の疫学調査について

    田村 立, 遠藤 太郎, 江川 純, 杉本 篤言, 染矢 俊幸

    小児の精神と神経   51 ( 4 )   348 - 350   2011.12

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  • トリプトファン水酸化酵素2(TPH2)遺伝子と広汎性発達障害との関連

    江川 純, 遠藤 太郎, 田村 立, 増澤 菜生, 杉山 登志郎, 染矢 俊幸

    小児の精神と神経   51 ( 3 )   286 - 287   2011.9

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  • 広汎性発達障害における利き手と視床体積との関連

    江川 純, 遠藤 太郎, 田村 立, 染矢 俊幸

    小児の精神と神経   51 ( 3 )   287 - 287   2011.9

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  • 発達障害は本当に増えているの? 我が国の疫学調査の実態から 新潟県阿賀野市における広汎性発達障害の疫学調査について

    田村 立, 遠藤 太郎, 江川 純, 杉本 篤言, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   105回   27 - 27   2011.6

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  • トリプトファン水酸化酵素2(TPH2)遺伝子と広汎性発達障害との関連

    江川 純, 遠藤 太郎, 田村 立, 増澤 菜生, 杉山 登志郎, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   105回   42 - 42   2011.6

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  • 広汎性発達障害における利き手と視床体積との関連

    江川 純, 遠藤 太郎, 田村 立, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   105回   42 - 42   2011.6

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  • 新潟県阿賀野市の就学時健診における自閉症スクリーニング質問紙を用いた広汎性発達障害の疫学調査

    江川 純, 田村 立, 遠藤 太郎, 杉本 篤言, 染矢 俊幸

    小児の精神と神経   50 ( 4 )   441 - 442   2010.12

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  • 精神科疾患の診断をめぐる諸問題 精神科医327名のアンケート調査から

    江川 純, 遠藤 太郎, 染矢 俊幸, 下田 和孝, 塩入 俊樹, 山田 尚登, 高橋 三郎

    精神医学   52 ( 9 )   891 - 898   2010.9

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    日本の国際的診断方式の使用状況を調査する目的でアンケート調査を実施し,327名の精神科医から回答を得た。回答者を基準派(診断に操作的診断基準を重視する群)と記述派(診断に記述的診断方法を重視する群)に分け,その比較を中心に解析した。基準派の中でも説明・告知には記述的診断方法を用いるものが17.7%,記述派の中でも明確な診断基準による診断を治療上有用と答えたものが45.3%おり,また代表的な4つの精神疾患の診断確定法では,記述派は疾患により多様な診断方法を用いるなど,両派にはともに目的別に両診断を使い分ける群が存在した。双方の長所と短所を十分に把握したうえで,互いの短所を相補う形で用いられることが望ましいと考えられた。(著者抄録)

    DOI: 10.11477/mf.1405101697

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  • 新潟県阿賀野市の就学時健診における自閉症スクリーニング質問紙を用いた広汎性発達障害の疫学調査

    江川 純, 田村 立, 遠藤 太郎, 杉本 篤言, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   103回   23 - 23   2010.6

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  • 発達障害同胞併発例の検討

    小野 真樹, 江川 純, 森本 武志, 川村 昌代, 浦野 葉子, 栗山 貴久子, 東 誠, 杉山 登志郎

    子どもの心とからだ   18 ( 2 )   319 - 319   2009.12

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  • 【小児科医のための思春期医学・医療】 思春期における診療 広汎性発達障害

    江川 純, 遠藤 太郎, 染矢 俊幸

    小児科   50 ( 11 )   1755 - 1761   2009.10

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    Other Link: http://search.jamas.or.jp/link/ui/2010060674

  • セロトニン・トランスポーターおよびセロトニン受容体の遺伝子多型が自閉症スペクトラム者の脳体積・生化学代謝に及ぼす影響

    遠藤 太郎, 田村 立, 江川 純, 杉本 篤言, 染矢 俊幸

    日本児童青年精神医学会総会抄録集   50回   325 - 325   2009.9

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  • 代理によるミュンヒハウゼン症候群(Munchhanusen Syndrome by Proxy)の症例報告

    江川 純, 遠藤 太郎, 杉山 登志郎, 小野 真樹, 森本 武志, 川村 昌代, 浦野 葉子, 栗山 貴久子, 東 誠, 染矢 俊幸

    日本小児精神神経学会プログラム・抄録集   101回   21 - 21   2009.6

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  • 発達障害同胞併発例の検討

    小野 真樹, 江川 純, 森本 武志, 川村 昌代, 浦野 葉子, 栗山 貴久子, 東 誠, 杉山 登志郎

    日本小児精神神経学会プログラム・抄録集   101回   29 - 29   2009.6

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  • 反抗挑戦性障害の臨床的検討

    浦野 葉子, 江川 純, 小野 真樹, 森本 武志, 川村 昌代, 東 誠, 杉山 登志郎

    日本小児精神神経学会プログラム・抄録集   101回   23 - 23   2009.6

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    Language:Japanese   Publisher:(一社)日本小児精神神経学会  

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  • 【発達障害のリハビリテーション】 軽度発達障害の二次的障害と社会的転帰

    江川 純, 杉山 登志郎

    MEDICAL REHABILITATION   ( 103 )   27 - 31   2009.3

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    Language:Japanese   Publisher:(株)全日本病院出版会  

    高機能広汎性発達障害や注意欠如・多動性障害、学習障害などの軽度発達障害児は、不適応を生じやすいが、知的能力の遅れが軽度のため、その存在に気付かれにくく、虐待やいじめを受けるリスクが高い。そのため慢性的なストレスを受け、これを一因として気分症状、強迫症状、幻聴や被害念慮など精神病様症状、フラッシュバック、解離症状、チック、頭痛、嘔気、腹痛など心身症的な訴え、不登校などの学校不適応、社会的ひきこもり、犯罪などの反社会的行動、パーソナリティ障害など様々な二次的障害につながるが、この二次的障害の有無によって社会的転帰は大きく左右される。二次的障害を未然に防ぐためにも軽度発達障害の早期診断・早期療育を行うことは最重要課題である。また、二次的障害への進展に多大な影響を与える虐待といじめについての問題点、対応などについても考察した。(著者抄録)

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  • 【ADHDと呼ばれる子どもたち】 AD/HDという概念の意味するもの

    江川 純, 杉山 登志郎

    教育と医学   56 ( 12 )   1152 - 1162   2008.12

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    Language:Japanese   Publisher:慶應義塾大学出版会(株)  

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  • Neuroimaging-genetic study of autism spectrum disorders

    ( 44 )   75 - 81   2008

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  • そこが知りたい 薬物療法Q&A ADHD治療薬はADHDに併存する反抗挑戦性障害や行為障害に対しても有効か?

    江川 純, 遠藤 太郎, 染矢 俊幸

    臨床精神薬理   9 ( 10 )   2069 - 2070   2006.10

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    Language:Japanese   Publisher:(株)星和書店  

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  • 新潟大学医歯学総合病院精神科における継続・維持電気痙攣療法

    江川 純, 布川 綾子, 村竹 辰之, 染矢 俊幸

    新潟医学会雑誌   120 ( 10 )   601 - 601   2006.10

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    Language:Japanese   Publisher:新潟医学会  

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  • そこが知りたい 薬物療法Q&A 現在日本では2剤のADHD治療薬が治験中であるが,それぞれどのような薬理作用を持つのか?

    江川 純, 遠藤 太郎, 染矢 俊幸

    臨床精神薬理   9 ( 3 )   439 - 441   2006.3

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    Language:Japanese   Publisher:(株)星和書店  

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  • そこが知りたい薬物療法Q&A 広汎性発達障害のこだわりに対してSSRIは有効か?

    江川 純, 遠藤 太郎, 染矢 俊幸

    臨床精神薬理   8 ( 9 )   1439 - 1440   2005.9

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  • 顕著な陰性症状にペロスピロンが有効であった統合失調症の1例

    横山 裕一, 阿部 美紀, 江川 純, 染矢 俊幸

    新潟医学会雑誌   118 ( 8 )   434 - 435   2004.8

  • Risperidoneにより妄想とこだわり行動が改善した高機能自閉症の1例

    江川 純, 阿部 美紀, 横山 裕一, 染矢 俊幸

    新潟医学会雑誌   118 ( 8 )   435 - 435   2004.8

  • 研修医を応援する 処方奏効・失敗例 Risperidoneにより幻覚妄想とこだわり行動が改善した高機能自閉性障害の1例

    江川 純, 阿部 美紀, 塩入 俊樹, 染矢 俊幸

    臨床精神薬理   7 ( 7 )   1245 - 1250   2004.7

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    Language:Japanese   Publisher:(株)星和書店  

    IQ70以上の高機能自閉性障害に幻覚妄想を合併した症例(34歳男性)を経験した.幻覚妄想状態に伴う行動化が激しくなり,閉鎖病棟に医療保護入院となった.入院時からrisoperidoneによる治療を試み,入院1ヵ月後に6mg/日に増量した頃から,疎通性も改善し,幻聴の頻度も減っていった.また入院前に悪化した時間へのこだわり,自分の行動を細かくメモしたり,いつも定位置に座るなどの常同行為は著しく軽減され,対人機能も改善した.しかし,このrisperidoneの効果が単に幻覚妄想状態の改善に伴うものなのか,こだわり行為そのものに効いていたのかは現段階では定かではない

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