Updated on 2023/02/05

写真a

 
YAMAMOTO Tomohiro
 
Organization
University Medical and Dental Hospital Perinatal Intensive Care Center Lecturer
Title
Lecturer
External link

Degree

  • Ph.D. ( 2012.3   Niigata University )

  • 学士(医学) ( 2004.3   昭和大学 )

Research Interests

  • congenital heart disease

  • ultrasound cardiography

  • neurophysiology

  • anesthesiology

  • cardiac anesthesiology

Research Areas

  • Life Science / Anesthesiology

  • Life Science / Emergency medicine

  • Life Science / Cardiovascular surgery

Research History (researchmap)

  • Niigata University   Lecturer

    2018.4

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  • German Children Heart Center/Asklepios Children Hospital (Sankt Augustin, GERMANY)   Department of Paediatric Anaesthesiology and Critical Care Medicine   board certified anesthesiologist(GERMANY)

    2012.3 - 2018.3

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  • Niigata University Graduate School of Medical and Dental Sciences   Division of Anesthesiology   anesthesiologist

    2009.4 - 2012.3

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  • Niigata Prefectural Central Hospital   Division of Anesthesiology   anesthesiologist

    2008.7 - 2009.3

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  • Niigata University Medical and Dental Hospital   Division of Anesthesiology   anesthesiologist

    2008.4 - 2008.6

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  • Niigata University Medical and Dental Hospital   Division of Anesthesiology   senior resident

    2006.4 - 2008.3

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  • Niigata University Medical and Dental Hospital   junior resident

    2004.4 - 2006.3

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Research History

  • Niigata University   University Medical and Dental Hospital Perinatal Intensive Care Center   Lecturer

    2018.4

Education

  • Niigata University   Graduate School of Medical and Dental Sciences

    2009.4 - 2012.3

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  • Showa University   School of Medicine

    1998.4 - 2004.3

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Professional Memberships

  • JAPANESE SOCIETY OF ANESTHESIOLOGISTS

    2006.4

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  • Berufsverband deutscher Anästhesisten (GERMANY)

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  • LandesärztekammerRheinland-Pfalz (GERMANY)

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  • Bezirksärztekammer Koblenz (GEMRNAY)

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  • THE JAPANESE SOCIETY OF PEDIATRIC ANESTHESIOLOGY

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  • THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA

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  • JAPANESE SOCIETY OF CARDIOVASCULAR ANESTHESIOLOGISTS

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  • Ärztekammer Nordrhein (GERMANY)

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Studying abroad experiences

  • Asklepios Kinderklinik Sankt Augustin / Deutsches Kinderherzzentrum   麻酔科専門医(ドイツ)

    2012.3 - 2018.3

Qualification acquired

  • 麻酔科専門医(ドイツ)

  • ドイツ医師免許

  • 麻酔科専門医

  • Doctor

 

Papers

  • Ideal Depth of Endotracheal Intubation at the Vocal Cord Level in Pediatric Patients Considering Racial Differences in Tracheal Length Reviewed

    Tomohiro Yamamoto, Ehrenfried Schindler

    Journal of Clinical Medicine   11 ( 3 )   864 - 864   2022.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:{MDPI} {AG}  

    File: Ideal Depth of Endotracheal Intubation at the Vocal Cord Level in Pediatric Patients Considering Racial Differences in Tracheal Length.pdf

    DOI: 10.3390/jcm11030864

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  • Unexpected difficult airway due to an undiagnosed congenital lingual thyroglossal duct cyst in a neonate without stridor: A case report Reviewed

    Yoshiki Kohashi, Tomohiro Yamamoto, Miki Igarashi, Hironobu Nishimaki

    Clinical Case Reports   10 ( 2 )   2022.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    File: Unexpected difficult airway due to an undiagnosed congenital lingual thyroglossal@Clinical Case Reports.pdf

    DOI: 10.1002/ccr3.5475

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  • Paradoxical Platypnea-Orthodeoxia Syndrome Induced by Patent Foramen Ovale and Highly Tortuous Descending Thoracic Aorta: A Case Report Reviewed

    Yoshiki Kohashi, Tomohiro Yamamoto, Mika Yuza, Hironobu Nishimaki

    A&A Practice   15 ( 7 )   e01493 - e01493   2021.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1213/xaa.0000000000001493

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  • Ensure an “Ultrasound Window” on the Patient's Neck to Evaluate Cerebral Blood Flow! Reviewed

    Tomohiro Yamamoto, Takehito Mishima, Shuichi Shiraishi, Takeshi Saito, Ehrenfried Schindler

    The Thoracic and Cardiovascular Surgeon   70 ( 1 )   50 - 55   2021.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Georg Thieme Verlag KG  

    <title>Abstract</title>Near-infrared spectroscopy (NIRS) does not provide information about changes in oxygenation in whole-brain areas. Although the branching vessels of the aortic arch are not always easy to identify using transesophageal echocardiography (TEE), the blood flow status of cervical arteries can always be assessed by applying an ultrasound probe via the “ultrasound window” on the patient's neck, which can be ensured by devising alternative insertion approaches of the central venous catheter. This method is very simple but compensates for the limitations of the combination of NIRS and TEE, especially during cardiac surgery with cardiopulmonary bypass management using selective cerebral perfusion.

    DOI: 10.1055/s-0041-1725181

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  • A mechanism of re-sedation caused by remimazolam. Reviewed

    Tomohiro Yamamoto, Miyuki Kurabe, Yoshinori Kamiya

    Journal of anesthesia   35 ( 3 )   467 - 468   2021.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-021-02930-y

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  • Re-sleeping after reversal of remimazolam by flumazenil. Reviewed

    Tomohiro Yamamoto, Miyuki Kurabe, Yoshinori Kamiya

    Journal of anesthesia   35 ( 2 )   322 - 322   2021.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-021-02915-x

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  • Precautions with right supraclavicular approach and oximetry central venous catheter. Reviewed International journal

    Tomohiro Yamamoto, Yusuke Mitsuma, Ehrenfried Schindler

    Anaesthesiology intensive therapy   53 ( 2 )   184 - 186   2021.3

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Precautions with right supraclavicular approach@AIT.pdf

    DOI: 10.5114/ait.2021.104098

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  • A real-time ultrasound-guided supraclavicular approach to the brachiocephalic vein to prevent Hickman catheter bending and occlusion Reviewed

    Tomohiro Yamamoto, Yuhki Arai, Ehrenfried Schindler

    Anaesthesiology Intensive Therapy   53 ( 3 )   274 - 276   2021.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Termedia Sp. z.o.o.  

    File: A real-time ultrasound-guided supraclavicular@AIT.pdf

    DOI: 10.5114/ait.2020.103511

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  • Preoperative Implementation of Transverse Thoracic Muscle Plane Block and Rectus Sheath Block Combination for Pediatric Cardiac Surgery Reviewed International journal

    Tomohiro Yamamoto, Yutaka Seino, Keiichiro Matsuda, Hidekazu Imai, Keiko Bamba, Ai Sugimoto, Shuichi Shiraishi, Preoperative Implementation of, Transverse Thoracic Muscle, Plane Block, Rectus Sheath, Block Combination for, Pediatric Cardiac Surgery

    Journal of Cardiothoracic and Vascular Anesthesia   34 ( 12 )   3367 - 3372   2020.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Systemic intravenous administration of opioids is the main treatment strategy for intraoperative and postoperative pain management in patients undergoing cardiac surgery with sternotomy. However, using lower doses of opioids may achieve the well-established benefits of the fast-track approach, with minimal opioid-related side effects. Postoperative pain is coupled with a long stay in the intensive care unit. Although neuraxial anesthesia has some benefits, its use remains controversial due to the potential development of epidural hematoma after anticoagulation for cardiopulmonary bypass and coagulopathy after cardiac surgery. Therefore, there is a need for other effective postoperative analgesic strategies, such as peripheral nerve blocks other than neuraxial anesthesia, for cardiac surgery with sternotomy. The effects of real-time ultrasound-guided transverse thoracic muscle plane (TTP) block on postoperative pain after sternotomy have been reported; however, the pain and discomfort in the epigastric area caused by chest drainage tubes placed through the rectus abdominis muscle also are major postoperative problems after cardiac surgery. Herein, the authors report on a preoperative combination of TTP block and rectus sheath block (RSB) for postoperative pain management after cardiac surgery with sternotomy that addresses pain in both the chest and epigastric areas. Considering previous studies, it is presumed that preemptive analgesic effects can be expected via a combination of the TTP block and RSB, and indeed, the preemptive effect was observed in the present study's patients. In this article, the procedure and tips for combining the TTP block and RSB are introduced.

    DOI: 10.1053/j.jvca.2020.07.041

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  • Precaution: Oximetry central venous catheter shaft is no longer waterproof when cut Reviewed International journal

    Tomohiro Yamamoto, Keiichiro Matsuda, Shuichi Shiraishi, Ehrenfried Schindler

    Anaesthesiology Intensive Therapy   53 ( 3 )   271 - 273   2020.10

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Termedia Sp. z.o.o.  

    his letter discusses precautions regarding the waterproof structure of the oximetry central venous catheter (CVC) shaft and the risk of blood reflux and leakage that can occur when the catheter shaft is cut. To assess oxygen supply-demand balance [1] and haemodynamics [2], the Swan-Ganz pulmonary artery catheter has been used for perioperative and postoperative management and treatment of critically ill patients for a half a century. In current clinical practice, haemodynamic parameters such as stroke volume (SV) and cardiac output (CO), as well as central venous oxygen saturation (ScvO2), can be measured continuously using a combination of FloTrac Sensor (Edwards Lifesciences Japan Ltd., Tokyo, Japan) [3], Edwards PreSep Oximetry Catheter (Edwards Lifesciences Japan Ltd., Tokyo, Japan) [4], and EV1000 Clinical Platform (Edwards Lifesciences Japan Ltd., Tokyo, Japan) or Vigileo Monitor (Edwards Lifesciences Japan Ltd., Tokyo, Japan) [5, 6]. These methods are less invasive than the Swan-Ganz pulmonary artery catheter, and the changes in the parameter values can be used as an index for perioperative management in both cardiovascular and non-cardiovascular surgeries. In addition, they can be used for the treatment of critically ill patients in the intensive care unit, enabling proactive determination of an appropriate therapy [7]. Compared to intermittent sampling and traditional vital signs alone, continuous ScvO2 monitoring is a more sensitive indicator of tissue perfusion because it reveals the true adequacy of tissue oxygenation, enabling early detection and assessment of clinical response to intervention [7, 8].

    File: Precaution Oximetry central venous catheter shaft@AIT.pdf

    DOI: 10.5114/ait.2020.100300

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  • Pediatric central venous catheter insertion: introduction of a real-time ultrasound-guided supraclavicular approach Invited Reviewed

    Tomohiro Yamamoto, M.D., Ph.D

    Clinical Pediatric Anesthesia   26 ( 1 )   73 - 81   2020.10

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    Authorship:Lead author, Corresponding author   Language:Japanese  

    J-GLOBAL

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  • Novel Choices of Cannula for Blood Delivery via Femoral Artery in Pediatric Patients Reviewed International journal

    Tomohiro Yamamoto, Takeshi Saito, Shuichi Shiraishi, Boulos Asfour, Victor Hraska, Ehrenfried Schindler

    The Thoracic and Cardiovascular Surgeon   70 ( 1 )   45 - 49   2020.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Georg Thieme Verlag KG  

    <title>Abstract</title>We previously presented a cardiopulmonary bypass (CPB) method with blood delivery via femoral artery cannulation for pediatric aortic arch repair operations using the Radifocus Introducer sheath. However, the flow rate with the Radifocus Introducer sheath is limited by accessory parts with the same structure having a smaller inner diameter among different sizes, rather than the sheath body. Therefore, we further devised a combination of the JELCO IV catheter, an extension tube, and a three-way stopcock with a larger opening to obtain more flow rate keeping the CPB circuit pressure significantly lower than when using the Radifocus Introducer sheath successfully.

    DOI: 10.1055/s-0040-1715604

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  • Ideal Depth of Tracheal Intubation in Pediatric Patients Using the Distance between Vocal Cords and Tracheal Bifurcation Invited Reviewed

    Tomohiro Yamamoto

    The Journal of Japan Society for Clinical Anesthesia   40 ( 4 )   343 - 348   2020.7

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    Authorship:Lead author, Corresponding author   Language:Japanese  

    J-GLOBAL

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  • Congenital Tracheal Aplasia Without Prenatal Diagnosis Masked by Maternal Obesity and Gestational Diabetes Reviewed International journal

    Tomohiro Yamamoto, Miyuki Kurabe, Kensuke Matsumoto, Shunya Sugai, Hiroshi Baba

    A & A Practice   14 ( 6 )   e01200 - e01200   2020.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    This case report describes a neonate with tracheal aplasia first diagnosed after birth due to the presentation of respiratory distress, absence of crying, and unsuccessful tracheal intubation. The most common finding with tracheal aplasia is polyhydramnios. However, diagnosis remains challenging in the prenatal period. In this case, maternal obesity and gestational diabetes made diagnosis more difficult. The only lifesaving treatment available is ventilation through esophageal intubation or tracheostomy. However, in some cases, tracheostomy is not an option.

    DOI: 10.1213/xaa.0000000000001200

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  • Tips and tricks: Real-time ultrasound-guided left supraclavicular approach as a rapidly applied alternative venous access in paediatric difficult peripheral vein cases. Reviewed

    Tomohiro Yamamoto, Ehrenfried Schindler

    European Journal of Anaesthesiology   37 ( 2 )   152 - 154   2020.2

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  • Self-BURP maneuver in laryngoscopy in paediatric patients Reviewed

    Tomohiro Yamamoto, Ehrenfried Schindler

    Anaesthesiology Intensive Therapy   52 ( 1 )   74 - 75   2020.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Termedia Sp. z.o.o.  

    File: AIT_Art_39991-10.pdf

    DOI: 10.5114/ait.2020.93317

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  • Real-time ultrasound-guided supraclavicular technique as a possible alternative approach for Hickman catheter implantation. Reviewed

    Tomohiro Yamamoto, Yuhki Arai, Ehrenfried Schindler

    Journal of Pediatric Surgery   55 ( 6 )   1157 - 1161   2019.12

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  • My Experience as an Anesthesiologist in Germany Invited Reviewed

    Tomohiro Yamamoto

    The Journal of Japan Society for Clinical Anesthesia   39 ( 4 )   400 - 407   2019.7

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (conference, symposium, etc.)  

    File: ドイツの麻酔科医@日本臨床麻酔学会誌.pdf

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  • Cardiopulmonary bypass method with blood delivery via femoral artery cannulation for pediatric aortic arch repair. Reviewed

    Yamamoto T, Schindler E

    Pediatric Anesthesia   29 ( 8 )   885 - 886   2019.6

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  • A new way to determine correct depth of central venous catheter insertion using a real-time ultrasound-guided insertion technique in pediatric patients. Reviewed

    Yamamoto T, Schindler E

    Pediatric Anesthesia   29 ( 4 )   368 - 376   2019.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pan.13614

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  • Complications associated with nasotracheal intubation and proposal of simple countermeasure. Reviewed

    Yamamoto T, Flenner M, Schindler E

    Anaesthesiology Intensive Therapy   51 ( 1 )   72 - 73   2019.2

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    File: AIT_Art_37726-10.pdf

    DOI: 10.5603/AIT.a2019.0002

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  • Be on the alert again for the risk of pulmonary air embolisation in paediatric patients during the insertion of a central venous catheter under general anaesthesia with spontaneous respiration Reviewed

    Tomohiro Yamamoto, Yusuke Mitsuma, Hiroshi Baba

    Anaesthesiology Intensive Therapy   51 ( 5 )   412 - 413   2019

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Termedia Sp. z.o.o.  

    File: Be on the alert again for the risk of pulmonary air embolisation in paediatric patients during the insertion of a central venous catheter under general anaesthesia with spontaneous respiration.pdf

    DOI: 10.5114/ait.2019.89225

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  • New Drugs for Old Problems: Which Inotropes for Critically Ill Children? Reviewed

    Schindler E, Yamamoto T

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies   19 ( 7 )   674 - 675   2018.7

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/PCC.0000000000001559

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  • Real-Time Ultrasound-Guided Right Supraclavicular Approach to the Central Vein: An Alternative Option Reviewed

    Tomohiro Yamamoto, Ehrenfried Schindler

    ANESTHESIA AND ANALGESIA   125 ( 1 )   359 - 359   2017.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1213/ANE.0000000000002182

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  • Basic Preoperative Evaluation, Anesthesiological and Intensive Care Management in the Pediatric Patients (Chapter) Invited Reviewed

    Yamamoto T, Schindler E

    Textbook of Pediatric Neurosurgery   1 - 26   2017.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (other academic)  

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  • Bilateral Congenital Iris Sphincter Agenesis Diagnosed After Massive Bleeding Episode During Repair of Aneurysmal Dilation of Patent Ductus Arteriosus: A Case Report. Reviewed

    Yamamoto T, Schmidt-Niemann M, Schindler E

    A & A case reports   8 ( 7 )   155 - 157   2017.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/XAA.0000000000000451

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  • Notfälle im Rettungsdienst und in der Klinik: Gefäßzugänge bei Kindern. Reviewed

    Yamamoto T, Schindler E

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS   52 ( 1 )   55 - 64   2017.1

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    Authorship:Lead author, Corresponding author   Language:German   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0042-104853

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  • Where and how do anaesthetics act? Mechanisms of action in the central nervous system Reviewed

    Yamamoto T, Schindler E

    Anaesthesiology Intensive Therapy   49 ( 4 )   288 - 293   2017

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    File: Where and how do anaesthetics act Mechanisms of action in the central nervous system.pdf

    DOI: 10.5603/AIT.a2017.0046

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  • A Case of Acute Upper Airway Obstruction in a Pediatric Hemophilia A Patient Because of Spontaneous Retropharyngeal Hemorrhage Reviewed

    Tomohiro Yamamoto, Martin Schmidt-Niemann, Ehrenfried Schindler

    ANNALS OF EMERGENCY MEDICINE   67 ( 5 )   616 - 619   2016.5

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:MOSBY-ELSEVIER  

    We report a rare case of acute upper airway obstruction caused by spontaneous retropharyngeal hemorrhage as a result of hemophilia A in a 16-year-old pediatric patient who routinely received factor VIII replacement. Initial diagnosis was delayed because the patient presented with symptoms, such as throat pain and odynophagia, similar to those of common benign upper airway infections. Within 2 days of the initial presentation of symptoms, the patient went into respiratory failure as a result of retropharyngeal hemorrhage. The possibility of spontaneous retropharyngeal or epiglottic hemorrhage or hematoma should be considered as a cause of rapidly progressing odynophagia and dyspnea by hemophilia patients.

    DOI: 10.1016/j.annemergmed.2015.08.028

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  • Patients with congenital Heart Disease for non-cardiac Surgery Anesthesiological Management Reviewed

    Tomohiro Yamamoto, Ehrenfried Schindler

    ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE   51 ( 3 )   152 - 158   2016.3

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    Authorship:Lead author, Corresponding author   Language:German   Publishing type:Research paper (scientific journal)   Publisher:GEORG THIEME VERLAG KG  

    DOI: 10.1055/s-0041-103909

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  • Anaesthesia management for non-cardiac surgery in children with congenital heart disease. Reviewed

    Yamamoto T, Schindler E

    Anaesthesiology intensive therapy   48 ( 5 )   305 - 313   2016

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5603/AIT.a2016.0050

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  • Is the supraclavicular approach to the central vein still risky and taboo? Reviewed

    Tomohiro Yamamoto, Ehrenfried Schindler

    PEDIATRIC ANESTHESIA   25 ( 11 )   1176 - 1178   2015.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-BLACKWELL  

    DOI: 10.1111/pan.12734

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  • Prolonged Activated Clotting Time after Protamine Administration Does Not Indicate Residual Heparinization after Cardiopulmonary Bypass in Pediatric Open Heart Surgery Reviewed

    Tomohiro Yamamoto, Hans-Gerd Wolf, Nicodeme Sinzobahamvya, Boulos Asfour, Victor Hraska, Ehrenfried Schindler

    The Thoracic and Cardiovascular Surgeon   63 ( 5 )   397 - 403   2015.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:GEORG THIEME VERLAG KG  

    Background In open heart surgery, heparinization is commonly neutralized using an empirical heparin:protamine ratio ranging between 1:1 and 1:1.5. However, these ratios may result in protamine overdose that should be avoided for its negative side effects on the coagulation system. This study aimed to indicate the appropriate treatment for prolonged activated clotting time (ACT) after protamine administration following cardiopulmonary bypass (CPB) in pediatric open heart surgery by investigating the underlying reasons for it.
    Methods Twenty-seven children (&lt;10 kg) undergoing open heart surgery were included. Heparin was administered only before CPB (400 IU/kg) and in the pump priming volume for CPB (2,000 IU) and was neutralized by 1:1 protamine after CPB. The blood heparin concentration was measured using anti-Xa assay. ACT and blood concentrations of heparin, coagulation factors, thrombin-antithrombin complex, and prothrombin fragment 1 + 2 were assessed. A rotational thromboelastometry (ROTEM; Tem International GmbH, Munchen, Bayern, Germany) was used to confirm the coagulation status and residual heparin after protamine administration.
    Results Anti-Xa assay showed that there is no residual heparin in the blood after 1:1 protamine administration. Nevertheless, ACT (128.89 +/- 3.09 seconds before heparin administration) remained prolonged (177.14 +/- 5.43 seconds at 10 minutes after protamine, 182.00 +/- 5.90 seconds at 30 minutes after protamine). The blood concentrations of coagulation factors were significantly lower than those before heparin administration (p &lt; 0.01). The low FIBTEM MCF of ROTEM (4.43 +/- 0.32 mm) at 10 minutes after protamine indicated low fibrinogen concentration.
    Conclusion Prolonged ACT after heparin neutralization by 1:1 protamine administration does not necessarily indicate residual heparin, but low blood concentrations of coagulation factors should be considered as a reason as well. Accordingly, supply of coagulation factors instead of additional protamine should be considered.

    DOI: 10.1055/s-0035-1554998

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  • A case of anastomosis malposition of the Blalock-Taussig shunt diagnosed using perioperative transesophageal echocardiography monitoring Reviewed

    Tomohiro Yamamoto, Ehrenfried Schindler

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   28 ( 2 )   165 - 167   2014.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER HEIDELBERG  

    The perioperative transesophageal echocardiography (TEE) is a very useful and minimal invasive monitoring not only for the cardiac anesthesia management, but also for the anesthesia management of the non-cardiac operations of the heart high risk patients. In this case report, we report a case of the urgent Blalock-Taussig shunt (BT shunt) operation for a small patient of Fallot's tetralogy with anoxic spell, which showed an atypical change of hemodynamics and SpO(2) with the shunt opening. After the BT shunt anastomosis, the diastolic blood pressure decreased with the shunt opening, however, the expected rise of SpO(2) was not provided. By the perioperative TEE monitoring with the single plane TEE transducer for neonate; UST-52110S (Hitachi Aloka Medical, Tokyo, Japan) with 4.5 mm in diameter, the cause of this atypical change of hemodynamics and SpO(2) was diagnosed to be an accidental anastomosis malposition of the BT shunt to the right pulmonary vein and reported to the operator during the operation, and the operation was performed correctly.

    DOI: 10.1007/s10877-013-9509-7

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  • Cases of carbon dioxide rebreathing without significant color change in the appearance of the carbon dioxide absorbent canisters Reviewed

    Tomohiro Yamamoto

    JOURNAL OF ANESTHESIA   27 ( 5 )   807 - 808   2013.10

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER JAPAN KK  

    DOI: 10.1007/s00540-013-1606-8

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  • Ultrasound for vascular access in pediatric patients Reviewed

    Ehrenfried Schindler, Gregory J. Schears, Stuart R. Hall, Tomohiro Yamamoto

    PEDIATRIC ANESTHESIA   22 ( 10 )   1002 - 1007   2012.10

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-BLACKWELL  

    Objectives In pediatric patients vascular access is often more difficult than in adults because of the smaller size of the vessels and the inability of the patient to cooperate without deep sedation or general anesthesia. Therefore Ultrasound has already become an invaluable tool for vascular access, but the full potential of ultrasound has yet to be fully realized. Improvements in image quality and a better understanding of optimal insertion techniques continue to help clinicians safely and efficiently place catheters with fewer complications. Methods and Technique The probes used for the vascular access are mainly linear and convex type. Higher- frequency ultrasound provides a vivid image; however, the signals are remarkably attenuated. Therefore, the choice of the probe with appropriate frequency is essential. As blood vessels are relatively easily identified with ultrasound, ultrasound-guided vascular access does not require as sharp images as ultrasound-guided nerve block. For pediatric vascular access, the linear probe with 515 MHz, 25 cm depth is ideal and adequate for almost all cases. Ultrasound-guided vascular access has two main approaches: long-axis or in-plane approach and short-axis or transverse approach. The long-axis approach visualizes the vessel along the insertion pathway and is commonly used to monitor the entire approach of the needle into the vessel. The short-axis approach is easier to show the positional relationship and depth of target vessels, but it is much harder to follow the needle tip within the tissues. Conclusion The use of real-time ultrasound has been shown to increase first insertion success, reduce access time, have a higher overall success, and reduce arterial puncture. As the technology continues to improve the use of ultrasound will become as ubiquitous as the lines themselves.

    DOI: 10.1111/pan.12005

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  • Effect of Xenon on Excitatory and Inhibitory Transmission in Rat Spinal Ventral Horn Neurons Reviewed

    Tomohiro Yamamoto, Hiroyuki Honda, Hiroshi Baba, Tatsuro Kohno

    ANESTHESIOLOGY   116 ( 5 )   1025 - 1034   2012.5

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    Background: The minimum alveolar concentration is determined in the spinal cord rather than in the brain. Xenon inhibits glutamatergic excitatory synaptic transmission in the dorsal horn neurons. However, its actions in the ventral horn neurons have not been investigated.
    Methods: The effects of 50 or 75% xenon on excitatory and inhibitory synaptic transmission were examined in the spinal lamina IX neurons of neonatal rats by using a whole cell patch clamp technique.
    Results: Fifty percent xenon inhibited the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid-induced currents (amplitudes = 72 +/- 9% and integrated area = 73 +/- 13% of the control values), and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid receptor-mediated electrically evoked excitatory postsynaptic currents (amplitudes = 69 +/- 13% of the control values). Seventy-five percent xenon similarly inhibited alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid-induced currents. However, xenon had no effect on the N-methyl-D-aspartate-induced currents or N-methyl-D-aspartate receptor-mediated electrically evoked excitatory postsynaptic currents. Xenon decreased the amplitude, but not the frequency, of miniature excitatory postsynaptic currents. There were no discernible effects on the currents induced by gamma-aminobutyric acid or glycine or on miniature inhibitory postsynaptic currents.
    Conclusions: Xenon inhibits alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid receptor-mediated glutamatergic excitatory transmission in the spinal lamina IX neurons via a postsynaptic mechanism. In contrast, there are no substantial effects on N-methyl-D-aspartate receptor-mediated or inhibitory synaptic transmission. The suppressive effects on excitatory synaptic transmission in the ventral horn neurons partly account for the mechanism behind xenon's ability to produce immobility in response to noxious stimuli and to determine the minimum alveolar concentration.

    DOI: 10.1097/ALN.0b013e31825037a1

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  • Anesthetic Mechanisms in the Spinal Cord Invited Reviewed

    Tomohiro Yamamoto, Hiroyuki Honda, Tatsuro Kohno

    Japanese Journal of Anesthesia   60 ( 5 )   582 - 589   2011.5

  • A case of airway management by laryngeal mask airway for a child with laryngeal web undergoing adenotonsillectomy Reviewed

    Tomohiro Yamamoto, Tatsuro Kohno

    Japanese Journal of Anesthesiology   60 ( 2 )   214 - 216   2011.2

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    We report a case of airway management by laryngeal mask airway (LMA) for a 4-year-old boy with laryngeal web undergoing adenotonsillectomy. Although the patient had no symptoms of airway stenosis, we detected a subglottic laryngeal web during the preoperative examination. The opening orifice of the laryngeal web was estimated to be too small for intubation, and we chose to manage the airway with LMA and spontaneous respiration. Using the LMA and DavisCrowe mouth gag, we were able to provide the surgeon with the same exposure as with intubation while effectively managing the airway.

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  • A case of profound bradycardia and cardiac arrest during left upper lobectomy and lymph node dissection Reviewed

    Tomohiro Yamamoto, Takayuki Honma, Miho Ikoma, Hiroshi Baba, Tatsuro Kohno

    Japanese Journal of Anesthesiology   59 ( 12 )   1483 - 1486   2010.12

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    We present a case of profound bradycardia and cardiac arrest in a 61-year-old man, which occurred during left upper lobectomy and lymph node dissection for the ligamentum arteriosum. General anesthesia was maintained by propofol TIVA combined with epidural anesthesia. During the electrocautery dissection of the lymph node of the ligamentum arteriosum the patient became extremely bradycardic for 10 min. Subsequent traction with forceps further aggravated the bradycardia leading to cardiac arrest. In order to continue the procedure, we initiated epicardial pacing and switched to isoflurane anesthesia. Given the close proximity of the lymph node of the ligamentum arteriosum to the thoracic cardiac branch of the vagus nerve and the cardiac plexus, we believe that the observed bradycardia and cardiac arrest are likely attributable to vasovagal stimulation.

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MISC

  • 小児における超音波ガイド下中心静脈穿刺

    山本知裕

    日本臨床麻酔学会誌   41 ( 6 )   2021

  • 小児開心術における,末梢神経ブロックを用いたファストトラック周術期全身麻酔管理戦略

    山本知裕

    日本小児麻酔学会誌   ( Supplement )   2021

  • 小児の大動脈弓再建術における経大腿動脈送血法に使用するカニューレ選択の改善

    山本知裕

    Cardiovascular Anesthesia   24 ( Suppl (CD-ROM) )   2020

  • 小児における理想的な気管挿管チューブ挿入長について,声帯から気管分岐部までの距離を指標とした検討

    山本知裕, 山本知裕

    日本臨床麻酔学会誌   39 ( 6 )   2019

  • 小児患者の大動脈弓再建術における経大腿動脈送血法

    山本知裕, 松田敬一郎, 清野豊, 三ツ間祐介, 今井英一

    Cardiovascular Anesthesia   23 ( Suppl (CD-ROM) )   2019

  • 末梢静脈ライン確保困難時における緊急的左鎖骨上アプローチ静脈ライン確保

    山本知裕, 松田敬一郎, 清野豊, 番場景子, 今井英一

    Cardiovascular Anesthesia   23 ( Suppl (CD-ROM) )   2019

  • 小児CVC挿入:リアルタイムエコーガイド下鎖骨上アプローチの紹介

    山本知裕

    日本小児麻酔学会誌   25 ( Supplement )   2019

  • リアルタイム超音波ガイド下中心静脈カテーテル留置における理想的カテーテル留置長の簡便な推測方法の検討

    山本知裕, 山本知裕

    日本小児麻酔学会誌   24 ( Supplement )   2018

  • 僧帽弁置換術後に左冠動脈起始異常に気付かれたBland-White-Garland症候群の一例

    松田敬一郎, 山本知裕, 清野豊, 番場景子, 今井英一

    Cardiovascular Anesthesia   22 ( Suppl )   2018

  • リアルタイム超音波ガイド下中心静脈鎖骨上アプローチ

    山本知裕

    日本小児麻酔学会誌   23 ( 1 )   2017

  • 動脈瘤化巨大動脈管開存症と先天性瞳孔括約筋欠損症の合併症例

    山本知裕

    日本小児麻酔学会誌   23 ( 1 )   2017

  • 小児開心術時,人工心肺離脱時のプロタミン投与後にACT値が依然延長している場合の原因は何か?

    山本知裕, WOLF Hans-Gerd, SCHINDLER Ehrenfried

    日本臨床麻酔学会誌   34 ( 6 )   2014

  • 小児心臓手術時の人工心肺離脱後のACTの延長はヘパリンの残存が原因ではない

    山本知裕, WOLF Hans-Gerd, SCHINDLER Ehrenfried

    Cardiovascular Anesthesia   17 ( Suppl )   2013

  • デクスメデトミジンを用いた喉頭形成術の麻酔経験

    外山美紗, 當重一也, 山本知裕, 持田崇, 篠原由華, 本間富彦, 渡辺逸平, 丸山正則

    麻酔   58 ( 8 )   2009

  • SGシース挿入時,動脈穿通により胸腔内大量出血を来した1例

    山本知裕, 山本知裕

    日本臨床麻酔学会誌   28 ( 6 )   2008

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Presentations

  • Real-time Ultrasound-guided Vascular Access in Pediatric Patients Invited

    Tomohiro Yamamoto

    The 41th Annual Meeting of the Japan Society of Clinical Anesthesia  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • Fast-Track Perioperative General Anesthesia Management Strategy with Peripheral Nerve Blocks in Pediatric Cardiac Surgery (Combination of Transverse Thoracic Muscle Plane Block and Rectus Sheath Block) Invited

    Tomohiro Yamamoto

    The 26th Annual Meeting of the Japanese Society of Pediatric Anesthesiology  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • Improved choice of cannulas for cardiopulmonary bypass method with blood delivery via femoral artery cannulation for pediatric aortic arch repair

    Tomohiro Yamamoto

    The 25th Annual Meeting of Japanese Society of Cardiovascular Anesthesiologists  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

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  • CVC insertion in pediatric patients : Real-time ultrasound-guided supraclavicular approach Invited

    Tomohiro Yamamoto

    The 25th Annual Meeting of the Japanese Society of Pediatric Anesthesiology  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • 小児における理想的な気管挿管チューブ挿入長について、声帯から気管分岐部までの距離を指標とした検討

    山本知裕

    日本臨床麻酔学会第39回大会  2019.11 

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  • 末梢静脈ライン確保困難時における緊急的左鎖骨上アプローチ静脈ライン確保

    山本知裕

    日本心臓血管麻酔学会第24回学術大会  2019.9 

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  • 小児患者の大動脈弓再建術における経大腿動脈送血法

    山本知裕

    日本心臓血管麻酔学会第24回学術大会  2019.9 

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  • Real-timeultrasound-guided left supraclavicular vein access as an alternative approach in cases of difficult peripheral venous access International conference

    YAMAMOTO Tomohiro

    Euroanaesthesia (the European Anaesthesiology Congress) 2019 Annual Meeting of the European Society of Anaesthesioligy (ESA)  2019.6 

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  • ドイツの麻酔科医 Invited

    山本知裕

    日本臨床麻酔学会 第38回大会  2018.11 

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  • リアルタイム超音波ガイド下中心静脈カテーテル留置における理想的カテーテル留置長の簡易的な推測方法の検討

    山本知裕

    日本小児麻酔学会 第24回大会  2018.10 

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  • Ideal depth of central venous catheters using a real-time ultrasound-guided technique in pediatric patients with congenital heart diseases. International conference

    YAMAMOTO Tomohiro

    Euroanaesthesia (the European Anaesthesiology Congress) 2018 Annual Meeting of the European Society of Anaesthesioligy (ESA)  2018.6 

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  • 動脈瘤化巨大動脈管開存症と先天性瞳孔括約筋欠損症の合併症例

    山本知裕

    日本小児麻酔学会 第23回大会  2017.10 

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  • リアルタイム超音波ガイド下中心静脈鎖骨上アプローチ

    山本知裕

    日本小児麻酔学会 第23回大会  2017.10 

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  • 動脈瘤化巨大動脈管開存症手術における大量出血を機に診断された、先天性瞳孔括約筋欠損症の新生児の一例

    山本知裕

    日本麻酔科学会 第63回学術集会  2016.5 

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  • 自然発症した喉頭部軟部組織内出血から上気道閉塞を来した血友病A小児患者の一例

    山本知裕

    日本麻酔科学会 第62回学術集会  2015.5 

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  • 小児開心術時、人工心肺離脱時のプロタミン投与後、ACT値が依然延長している場合の原因は何か?

    山本知裕

    日本臨床麻酔学会 第34回大会  2014.11 

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  • High activated clotting time level after cardiopulmonary bypass in paediatric heart surgery does not indicate residual heparin in the blood International conference

    YAMAMOTO Tomohiro

    2014 Annual Meeting of the European Association of Cardiothoracic Anesthesiologists (EACTA)/International Congress of Cardiovascular Anesthesia (ICCVA)  2014.9 

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  • 小児心臓手術時の人工心肺離脱後のACT値延長はヘパリンの残存が原因ではない

    山本知裕

    日本心臓血管麻酔学会 第18回学術大会  2013.9 

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  • 術中経食道心臓エコーによりBTシャント吻合位置異常を指摘した一例

    山本知裕

    日本心臓血管麻酔学会 第17回学術大会  2012.9 

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  • Effect of Xenon on Excitatory and Inhibitory Transmission in Rat Spinal Ventral Horn Neurons International conference

    YAMAMOTO Tomohiro

    American Society of Anesthesiologist (ASA) 2011 Annual Meeting  2011.10 

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  • sacculation of the uterus 合併妊娠における帝王切開の麻酔経験

    山本知裕

    日本麻酔科学会 関東甲信越・東京支部 第49回合同学術集会  2009.9 

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Awards

  • Best case reports award in peer-reviewed English-language journals

    2022.10   The Japanese Society of Pediatric Anesthesiology   Congenital Tracheal Aplasia Without Prenatal Diagnosis Masked by Maternal Obesity and Gestational Diabetes: A Case Report (A A Pract . 2020 Apr;14(6):e01200. doi: 10.1213/XAA.0000000000001200.)

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  • Best Presentation Award of the 39th Annual Meeting of the Japan Society for Clinical Anesthesia

    2019.11   The 39th Annual Meeting of the Japan Society for Clinical Anesthesia   Ideal Depth of Tracheal Intubation in Pediatric Patients Using the Distance between Vocal Cords and Tracheal Bifurcation

    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences

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  • Best Presentation Award of the Session

    2007.12   The 27th Annual Meeting of the Japan Society for Clinical Anesthesia   A Case of Profound Bradycardia and Cardiac Arrest during Left Upper Lobectomy and Lymph Node Dissection

    Division of Anesthesiology, Niigata University, Graduate School of Medical, Dental Sciences

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Research Projects

  • 脊髄前角運動ニューロンにおける麻酔薬の作用と、虚血神経保護作用の有無と作用機序

    Grant number:19K18289  2019.4 - 2022.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    山本 知裕

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    本研究では、まずは、現在一般的に臨床使用されている揮発性吸入麻酔薬であるセボフルランやデスフルラン、吸入麻酔薬である亜酸化窒素(笑気)の脊髄前角運動ニューロンにおける作用を電気生理学的手法により検討する。その後さらに、その研究結果を踏まえて、これらの吸入麻酔薬やキセノンが脊髄前角運動ニューロンにおいて虚血神経保護作用を有するかについても検討する。幼弱ラットin vitro脊髄スライスを用いて脊髄前角運動ニューロンからホールセルパッチクランプ記録を行い、セボフルランやデスフルラン、亜酸化窒素の脊髄前角運動ニューロンにおけるシナプス伝達機構に対する作用を調べる。また、同様に脊髄
    前角運動ニューロンからホールセルパッチクランプ記録を行い、セボフルランやデスフルラン、亜酸化窒素やキセノンの脊髄前角運動ニューロンにおける虚血神経保護作用の有無とそのメカニズムを明らかにする。
    幼弱ラットin vitro脊髄スライスを用いて脊髄前角運動ニューロンからホールセルパッチクランプ記録を行うため、脊髄スライス標本を乗せる記録用チャンバー、人工脳脊髄液や薬物を脊髄スライス標本へ投与するための灌流システム、脊髄前角に存在する運動ニューロンをテレビモニター下で観察・同定するための近赤外線システムを装備した顕微鏡、微小電極を誘導するためのマイクロマニピュレーター、ホールセル・パッチクランプ記録から得られた電気信号を増幅するためのパッチクランプ用増幅器などを備えた実験系システムを立ち上げた。

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  • 脊髄前角運動ニューロンにおけるキセノンおよび亜酸化窒素の作用と神経保護効果の検討

    Grant number:24791583  2012.4 - 2013.3

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    山本 知裕

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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