Updated on 2023/02/05

写真a

 
SEINO Yutaka
 
Organization
University Medical and Dental Hospital Operation Center Assistant Professor
Title
Assistant Professor
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Degree

  • 博士(医学) ( 2019.3 )

  • 博士(医学) ( 2019.3 )

Research Interests

  • 麻酔科学

  • 心臓麻酔

  • 先天性心疾患

Research Areas

  • Life Science / Anesthesiology

  • Life Science / Cardiovascular surgery

  • Life Science / Emergency medicine

Research History (researchmap)

  • 新潟大学医歯学総合病院   麻酔科   助教

    2021.4

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  • 魚沼基幹病院   麻酔科   特任助教

    2019.4 - 2021.3

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Research History

  • Niigata University   Operation Center, University Medical and Dental Hospital   Assistant Professor

    2022.4

  • Niigata University   Anesthesiology, University Medical and Dental Hospital   Assistant Professor

    2021.4 - 2022.3

  • Niigata University   University Medical and Dental Hospital UONUMA CHIIKI IRYO KYOIKU CENTER JUNBISHITU   Specially Appointed Assistant Professor

    2019.6 - 2021.3

Education

  • Niigata University   医歯学総合研究科

    2016.4 - 2019.3

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  • Niigata University   医学部医学科

    2002.4 - 2008.3

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Professional Memberships

 

Papers

  • Preoperative Implementation of Transverse Thoracic Muscle Plane Block and Rectus Sheath Block Combination for Pediatric Cardiac Surgery. International journal

    Tomohiro Yamamoto, Yutaka Seino, Keiichiro Matsuda, Hidekazu Imai, Keiko Bamba, Ai Sugimoto, Shuichi Shiraishi, Ehrenfried Schindler

    Journal of cardiothoracic and vascular anesthesia   34 ( 12 )   3367 - 3372   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    Systemic intravenous administration of opioids is the main treatment strategy for intraoperative and postoperative pain management in patients undergoing cardiac surgery with sternotomy. However, using lower doses of opioids may achieve the well-established benefits of the fast-track approach, with minimal opioid-related side effects. Postoperative pain is coupled with a long stay in the intensive care unit. Although neuraxial anesthesia has some benefits, its use remains controversial due to the potential development of epidural hematoma after anticoagulation for cardiopulmonary bypass and coagulopathy after cardiac surgery. Therefore, there is a need for other effective postoperative analgesic strategies, such as peripheral nerve blocks other than neuraxial anesthesia, for cardiac surgery with sternotomy. The effects of real-time ultrasound-guided transverse thoracic muscle plane (TTP) block on postoperative pain after sternotomy have been reported; however, the pain and discomfort in the epigastric area caused by chest drainage tubes placed through the rectus abdominis muscle also are major postoperative problems after cardiac surgery. Herein, the authors report on a preoperative combination of TTP block and rectus sheath block (RSB) for postoperative pain management after cardiac surgery with sternotomy that addresses pain in both the chest and epigastric areas. Considering previous studies, it is presumed that preemptive analgesic effects can be expected via a combination of the TTP block and RSB, and indeed, the preemptive effect was observed in the present study's patients. In this article, the procedure and tips for combining the TTP block and RSB are introduced.

    DOI: 10.1053/j.jvca.2020.07.041

    PubMed

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  • Efficacy of a novel urinary catheter for men with a local anesthetic injection port for catheter-related bladder discomfort: a randomized controlled study.

    Hidekazu Imai, Yutaka Seino, Hiroshi Baba

    Journal of anesthesia   34 ( 5 )   688 - 693   2020.10

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    PURPOSE: The NMOC-3WAY catheter® is a novel urinary catheter for men that can be used to inject a local anesthetic into the urethra. We sought to assess whether the injection of a local anesthetic into the urethra via the NMOC-3WAY catheter® would reduce catheter-related bladder discomfort (CRBD) after endovascular aneurysm repair (EVAR). METHODS: Adult male patients who underwent elective EVAR for abdominal aortic aneurysms were randomly assigned to the 2% lidocaine group and the normal saline group (control group). CRBD was evaluated at 0, 1, 2, 4, and 6 h after surgery. The primary outcome was the incidence of CRBD at 0 h after surgery. RESULTS: Data for 37 patients (19 in the lidocaine group and 18 in the control group) were analyzed. CRBD was observed at 0 h in six patients (31.6%; mild, n = 5; moderate, n = 1) in the lidocaine group and in five patients (27.8%; mild, n = 1; moderate, n = 3; severe, n = 1) in the control group. The control group showed a tendency to have severe CRBD at 0 h, although there was no significant difference in either the incidence (P = 0.80) or severity (P = 0.21) of CRBD between the two groups. CONCLUSION: Our results suggest that the use of the NMOC-3WAY catheter® for the injection of 2% lidocaine into the urethra does not reduce the incidence of CRBD immediately after EVAR. However, it may reduce moderate or severe CRBD that may lead to postoperative distress and agitation.

    DOI: 10.1007/s00540-020-02807-6

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  • Optimal Position of Inferior Vena Cava Cannula in Pediatric Cardiac Surgery: A Prospective, Randomized, Controlled, Double-Blind Study. International journal

    Yutaka Seino, Nobuko Ohashi, Hidekazu Imai, Hiroshi Baba

    Journal of cardiothoracic and vascular anesthesia   33 ( 5 )   1253 - 1259   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: To examine the authors' hypothesis that during the cardiopulmonary bypass (CPB) in children, the inferior vena cava cannula tip placed proximal to the right hepatic vein orifice would produce a higher venous drainage compared with that placed distally. DESIGN: A prospective, randomized, controlled, double-blind study. SETTING: Single university hospital. PARTICIPANTS: Thirty-two patients aged <6years, scheduled for elective cardiac surgery using CPB for congenital heart disease. INTERVENTIONS: Participants were randomized to 2 groups: the proximal group with the cannula tip placed proximally within 1cm of the right hepatic vein orifice and the distal group with the cannula placed distally within 1cm of the right hepatic vein orifice. MEASUREMENTS AND MAIN RESULTS: The primary outcome of this study was the perfusion flow rate at the time of establishment of total CPB with cardioplegia. The authors initially planned to enroll 60 patients, but before reaching the target sample size, the authors terminated this study owing to patient safety, and 18 patients in the proximal group and 14 patients in the distal group finally were analyzed. No significant differences in patient characteristics were observed between the 2 groups. The mean perfusion flow rate in the proximal group was significantly greater (2.55 ± 0.27 L/min/m2) than that in the distal group (2.37 ± 0.20 L/min/m2, p = 0.04). CONCLUSION: The inferior vena cava cannula tip placed in the proximal position was clinically superior, compared with a distal placement, in producing higher perfusion flow in children.

    DOI: 10.1053/j.jvca.2018.10.023

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  • Pediatric Patients with High Pulmonary Arterial Pressure in Congenital Heart Disease Have Increased Tracheal Diameters Measured by Computed Tomography. International journal

    Nobuko Ohashi, Hidekazu Imai, Yutaka Seino, Hiroshi Baba

    Journal of cardiothoracic and vascular anesthesia   32 ( 4 )   1676 - 1681   2018.8

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    OBJECTIVES: Determination of the appropriate tracheal tube size using formulas based on age or height often is inaccurate in pediatric patients with congenital heart disease (CHD), particularly in those with high pulmonary arterial pressure (PAP). Here, the authors compared tracheal diameters between pediatric patients with CHD with high PAP and low PAP. DESIGN: Retrospective clinical study. SETTING: Hospital. PARTICIPANTS: Pediatric patients, from birth to 6 months of age, requiring general anesthesia and tracheal intubation who underwent computed tomography were included. Patients with mean pulmonary artery pressure >25 mmHg were allocated to the high PAP group, and the remaining patients were allocated to the low PAP group. The primary outcome was the tracheal diameter at the cricoid cartilage level, and the secondary goal was to observe whether the size of the tracheal tube was appropriate compared with that obtained using predictable formulas based on age or height. MEASUREMENTS AND MAIN RESULTS: The mean tracheal diameter was significantly larger in the high PAP group than in the low PAP group (p < 0.01). Pediatric patients with high PAP required a larger tracheal tube size than predicted by formulas based on age or height (p = 0.04 for age and height). CONCLUSIONS: Pediatric patients with high PAP had larger tracheal diameters than those with low PAP and required larger tracheal tubes compared with the size predicted using formulas based on age or height.

    DOI: 10.1053/j.jvca.2017.12.004

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  • The endogenous agonist, β-alanine, activates glycine receptors in rat spinal dorsal neurons. International journal

    Yutaka Seino, Nobuko Ohashi, Tatsuro Kohno

    Biochemical and biophysical research communications   500 ( 4 )   897 - 901   2018.6

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    β-alanine is a structural analog of glycine and γ-aminobutyric acid (GABA) and is thought to be involved in the modulation of nociceptive information at the spinal cord. However, it is not known whether β-alanine exerts its effect in substantia gelatinosa (SG) neurons of the spinal dorsal horn, where glycine and GABA play an important role in regulating nociceptive transmission from the periphery. Here, we investigated the effects of β-alanine on inhibitory synaptic transmission in adult rat SG neurons using whole-cell patch-clamp. β-alanine dose-dependently induced outward currents in SG neurons. Current-voltage plots revealed a reversal potential at approximately -70 mV, which was close to the equilibrium potential of Cl-. Pharmacological analysis revealed that β-alanine activates glycine receptors, but not GABAA receptors. These results suggest that β-alanine hyperpolarizes the membrane potential of SG neurons by activating Cl- channels through glycine receptors. Our findings raise the possibility that β-alanine may modulate pain sensation through glycine receptors.

    DOI: 10.1016/j.bbrc.2018.04.183

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Books

  • LiSA 2021年4月号

    清野豊( Role: Contributor ,  血管穿刺:新生児や乳児の場合)

    メディカル・サイエンス・インターナショナル  2021.4 

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  • LiSA(別冊秋号)血圧

    清野豊, 今井英一( Role: Contributor ,  29.モニタリング)

    メディカル・サイエンス・インターナショナル  2019.9 

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MISC

  • 末梢静脈ライン確保困難時における緊急的左鎖骨上アプローチ静脈ライン確保

    山本知裕, 松田敬一郎, 清野豊, 番場景子, 今井英一

    Cardiovascular Anesthesia   23 ( Suppl (CD-ROM) )   2019

  • 僧帽弁置換術後に左冠動脈起始異常に気付かれたBland-White-Garland症候群の一例

    松田敬一郎, 山本知裕, 清野豊, 番場景子, 今井英一

    Cardiovascular Anesthesia   22 ( Suppl )   2018

Presentations

  • Efficacy of A Novel Urinary Catheter for Catheter-related Bladder Discomfort: A Randomized Controlled Study

    Hidekazu Imai, Yutaka Seino, Hiroshi Baba

    Anesthesiology Annual Meeting 2018  2018.10 

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    Language:English   Presentation type:Poster presentation  

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  • Optimal Position of Inferior Vena Cava Cannula in Pediatric Cardiac Surgery: A Randomized, Controlled Trial

    Yutaka Seino, Nobuko Ohashi, Hidekazu Imai, Hiroshi Baba

    Anesthesiology Annual Meeting 2018  2018.10 

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    Language:English   Presentation type:Poster presentation  

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  • Pediatric Patients with High Pulmonary Arterial Pressure in Congenital Heart Disease Have Increased Tracheal Diameters Measured

    Nobuko Ohashi, Hidekazu Imai, Yutaka Seino, Hiroshi Bab

    2018.10 

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    Language:English   Presentation type:Poster presentation  

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  • 僧帽弁置換術後に左冠動脈起始異常に気付かれた Bland−White−Garland 症候群の一例

    松田敬一郎, 山本知裕, 清野豊, 番場景子, 今井英一

    日本心臓血管麻酔学会第23回学術大会  2018.9 

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  • 腹部大動脈瘤ステントグラフト内挿術後患者における尿道内局 所麻酔薬注入のカテーテル関連膀胱不快感に対する効果の検討 ―無作為化二重盲検比較試験―

    今井 英一, 清野 豊, 馬場 洋

    日本麻酔科学会第65回学術集会  2018.5 

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  • 人工心肺離脱直後に心室中隔血腫を生じた1例

    大橋宣子, 清野豊, 今井英一, 馬場洋

    日本心臓血管麻酔学会第22回学術大会  2017.9 

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  • 肺体血圧比 (Pp/Ps)≒1の重症肺高血圧症患者の非心臓手術の麻酔経験

    清野豊, 大橋宣子, 今井英一

    日本心臓血管麻酔学会第22回学術大会  2017.9 

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  • 上行大動脈瘤に対してステントグラフト内挿術を行った2症例

    清野豊, 今井英一, 種岡美紀, 番場景子, 松田敬一郎, 馬場洋

    日本心臓血管麻酔学会第20回学術大会  2015.10 

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  • 肺動脈絞扼術における術中経食道心エコー所見と再手術との関連性の検討

    番場景子, 大橋宣子, 清野豊, 種岡美紀, 今井英一

    日本心臓血管麻酔学会第20回学術大会  2015.10 

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Research Projects

  • Elucidation of analgesic mechanism in spinal dorsal horn of beta-alanine

    Grant number:17K16725  2017.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Seino Yutaka, Ohashi Nobuko, Kohno Tatsuro

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    In this study, we performed electrophysiological experiments in the spinal dorsal horn of β-alanine. We found that β-alanine is involved in inhibitory synaptic transmission in the spinal dorsal horn. We also found that this effect was concentration dependent. We also investigated the receptors involved, and revealed that β-alanine acts through the Cl channel, and that it is not involved in the GABA A receptor but through the glycine receptor.

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