2022/12/01 更新

写真a

イトウ コウスケ
伊藤 浩介
ITOH Kosuke
所属
脳研究所 統合脳機能研究センター 准教授
職名
准教授
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外部リンク

学位

  • 理学博士 ( 2000年3月   京都大学 )

研究分野

  • ライフサイエンス / 認知脳科学

  • 人文・社会 / 認知科学

経歴

  • 新潟大学   脳研究所 統合脳機能研究センター   准教授

    2020年11月 - 現在

  • 新潟大学   脳研究所 統合脳機能研究センター   特任准教授

    2018年12月 - 2020年10月

  • 新潟大学   脳研究所   助教

    2002年6月 - 2018年11月

 

論文

  • Cerebral cortical processing time is elongated in human brain evolution

    Kosuke Itoh, Naho Konoike, Masafumi Nejime, Haruhiko Iwaoki, Hironaka Igarashi, Satoshi Hirata, Katsuki Nakamura

    Scientific Reports   12 ( 1 )   2022年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    <title>Abstract</title>An increase in number of neurons is presumed to underlie the enhancement of cognitive abilities in brain evolution. The evolution of human cognition is then expected to have accompanied a prolongation of net neural-processing time due to the accumulation of processing time of individual neurons over an expanded number of neurons. Here, we confirmed this prediction and quantified the amount of prolongation in vivo, using noninvasive measurements of brain responses to sounds in unanesthetized human and nonhuman primates. Latencies of the N1 component of auditory-evoked potentials recorded from the scalp were approximately 40, 50, 60, and 100 ms for the common marmoset, rhesus monkey, chimpanzee, and human, respectively. Importantly, the prominent increase in human N1 latency could not be explained by the physical lengthening of the auditory pathway, and therefore reflected an extended dwell time for auditory cortical processing. A longer time window for auditory cortical processing is advantageous for analyzing time-varying acoustic stimuli, such as those important for speech perception. A novel hypothesis concerning human brain evolution then emerges: the increase in cortical neuronal number widened the timescale of sensory cortical processing, the benefits of which outweighed the disadvantage of slow cognition and reaction.

    DOI: 10.1038/s41598-022-05053-w

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    その他リンク: https://www.nature.com/articles/s41598-022-05053-w

  • Comparison of non-invasive, scalp-recorded auditory steady-state responses in humans, rhesus monkeys, and common marmosets

    Naho Konoike, Haruhiko Iwaoki, Miki Miwa, Honami Sakata, Kosuke Itoh, Katsuki Nakamura

    Scientific Reports   12 ( 1 )   2022年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Auditory steady-state responses (ASSRs) are basic neural responses used to probe the ability of auditory circuits to produce synchronous activity to repetitive external stimulation. Reduced ASSR has been observed in patients with schizophrenia, especially at 40 Hz. Although ASSR is a translatable biomarker with a potential both in animal models and patients with schizophrenia, little is known about the features of ASSR in monkeys. Herein, we recorded the ASSR from humans, rhesus monkeys, and marmosets using the same method to directly compare the characteristics of ASSRs among the species. We used auditory trains on a wide range of frequencies to investigate the suitable frequency for ASSRs induction, because monkeys usually use stimulus frequency ranges different from humans for vocalization. We found that monkeys and marmosets also show auditory event-related potentials and phase-locking activity in gamma-frequency trains, although the optimal frequency with the best synchronization differed among these species. These results suggest that the ASSR could be a useful translational, cross-species biomarker to examine the generation of gamma-band synchronization in nonhuman primate models of schizophrenia.

    DOI: 10.1038/s41598-022-13228-8

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    その他リンク: https://www.nature.com/articles/s41598-022-13228-8

  • A novel “dip-in electrode” method for electrode application to record noninvasive scalp electroencephalograms and evoked potentials in an awake common marmoset

    Kosuke Itoh, Naho Konoike, Haruhiko Iwaoki, Hironaka Igarashi, Katsuki Nakamura

    Neuroimage: Reports   2 ( 3 )   100116 - 100116   2022年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.ynirp.2022.100116

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  • Noninvasive scalp recording of the middle latency responses and cortical auditory evoked potentials in the alert common marmoset. 国際誌

    Kosuke Itoh, Haruhiko Iwaoki, Naho Konoike, Hironaka Igarashi, Katsuki Nakamura

    Hearing research   405   108229 - 108229   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The common marmoset (Callithrix jacchus), a New World monkey, serves as a useful animal model in clinical and basic neuroscience. The present study recorded scalp auditory evoked potentials (AEP) in non-sedated common marmoset monkeys (n = 4) using a noninvasive method similar to that used in humans, and aimed to identify nonhuman primate correlates of the human AEP components. A pure tone stimulus was presented while electroencephalograms were recorded using up to 16 disk electrodes placed on the scalp and earlobes. Candidate homologues of two categories of the human AEP, namely, the middle latency responses (MLR; Na, Pa, Nb, and Pb) and the cortical auditory evoked potentials (CAEP; P1, N1, P2, N2, and the sustained potential, SP) were identified in the marmoset. These waves were labeled as CjNa, CjPa, CjNb, CjPb, CjP1, CjN1, CjP2, CjN2, and CjSP, where Cj stands for Callithrix jacchus. The last MLR component, CjPb, was identical to the first CAEP component, CjP1, similar to the relationship between Pb and P1 in humans. The peak latencies of the marmoset MLR and CAEP were generally shorter than in humans, which suggests a shorter integration time in neural processing. To our knowledge, the present study represents the first scalp recorded MLR and CAEP in the alert common marmoset. Further use of these recording methods would enable valid species comparisons of homologous brain indices between humans and animals.

    DOI: 10.1016/j.heares.2021.108229

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  • Participant-driven Simulation Protocol With a Mock Scanner for Pediatric Magnetic Resonance Neuroimaging Preparation Without Sedation 査読

    Kenichi Yamada, Yuji Suzuki, Satoshi Ueki, Kosuke Itoh, Masaki Watanabe, Kiyotaka Suzuki, Hironaka Igarashi

    Clinical Simulation in Nursing   47   40 - 47   2020年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.ecns.2020.07.002

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  • 絶対音感保持者における音階音と非音階音に対するミスマッチ陰性電位

    松田 将門, 伊藤 浩介, 五十嵐 博中

    臨床神経生理学   47 ( 5 )   427 - 427   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • Automaticity of pitch class-color synesthesia as revealed by a Stroop-like effect. 査読 国際誌

    Kosuke Itoh, Honami Sakata, Hironaka Igarashi, Tsutomu Nakada

    Consciousness and cognition   71   86 - 91   2019年5月

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    記述言語:英語  

    Pitch classes (e.g., do, re, and mi) in music evoke color sensations in pitch class-color synesthesia, which is a recently described form of synesthesia in musicians. The synesthetic color sensations were confirmed to be consistent over an extended time interval, fulfilling a widely-accepted criterion for the authenticity of synesthesia. However, it remains unclear whether the color sensations occurred automatically (i.e., without voluntary effort), which is another defining property of synesthesia. We utilized the Stroop paradigm to investigate this issue in 10 pitch class-color synesthetes. Participants were visually presented with pitch class names in font colors that were either congruent or incongruent with the participants' own color sensations. The speed for reporting the font color was slower when it was incongruent with the synesthetic sensation than when it was congruent. The finding verifies the authenticity of pitch class-color synesthesia by demonstrating that the color sensations occur automatically, even when unnecessary.

    DOI: 10.1016/j.concog.2019.04.001

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  • Evolutionary Elongation of the Time Window of Integration in Auditory Cortex: Macaque vs. Human Comparison of the Effects of Sound Duration on Auditory Evoked Potentials. 査読 国際誌

    Kosuke Itoh, Masafumi Nejime, Naho Konoike, Katsuki Nakamura, Tsutomu Nakada

    Frontiers in neuroscience   13   630 - 630   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The auditory cortex integrates auditory information over time to obtain neural representations of sound events, the time scale of which critically affects perception. This work investigated the species differences in the time scale of integration by comparing humans and monkeys regarding how their scalp-recorded cortical auditory evoked potentials (CAEPs) decrease in amplitude as stimulus duration is shortened from 100 ms (or longer) to 2 ms. Cortical circuits tuned to processing sounds at short time scales would continue to produce large CAEPs to brief sounds whereas those tuned to longer time scales would produce diminished responses. Four peaks were identified in the CAEPs and labeled P1, N1, P2, and N2 in humans and mP1, mN1, mP2, and mN2 in monkeys. In humans, the N1 diminished in amplitude as sound duration was decreased, consistent with the previously described temporal integration window of N1 (>50 ms). In macaques, by contrast, the mN1 was unaffected by sound duration, and it was clearly elicited by even the briefest sounds. Brief sounds also elicited significant mN2 in the macaque, but not the human N2. Regarding earlier latencies, both P1 (humans) and mP1 (macaques) were elicited at their full amplitudes even by the briefest sounds. These findings suggest an elongation of the time scale of late stages of human auditory cortical processing, as reflected by N1/mN1 and later CAEP components. Longer time scales of integration would allow neural representations of complex auditory features that characterize speech and music.

    DOI: 10.3389/fnins.2019.00630

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  • Auditory T-Complex Reveals Reduced Neural Activities in the Right Auditory Cortex in Musicians With Absolute Pitch. 査読 国際誌

    Masato Matsuda, Hironaka Igarashi, Kosuke Itoh

    Frontiers in neuroscience   13   809 - 809   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Absolute pitch (AP) is the ability to identify the pitch names of arbitrary musical tones without being given a reference pitch. The acquisition of AP typically requires early musical training, the critical time window for which is similar to that for the acquisition of a first language. This study investigated the left-right asymmetry of the auditory cortical functions responsible for AP by focusing on the T-complex of auditory evoked potentials (AEPs), which shows morphological changes during the critical period for language acquisition. AEPs evoked by a pure-tone stimulus were recorded in high-AP musicians, low-AP musicians, and non-musicians (n = 19 each). A balanced non-cephalic electrode (BNE) reference was used to examine the left-right asymmetry of the N1a and N1c components of the T-complex. As a result, a left-dominant N1c was observed only in the high-AP musician group, indicating "AP negativity," which has previously been described as an electrophysiological marker of AP. Notably, this hemispheric asymmetry was due to a diminution of the right N1c rather than enhancement of the left N1c. A left-dominant N1a was found in both musician groups, irrespective of AP. N1c and N1a exhibited no left-right asymmetry in non-musicians. Hence, music training and the acquisition of AP are both accompanied by a left-dominant hemispheric specialization of auditory cortical functions, as indexed by N1a and N1c, respectively, but the N1c asymmetry in AP possessors was due to reduced neural activities in the right hemisphere. The use of a BNE is recommended for evaluating these radially oriented components of the T-complex.

    DOI: 10.3389/fnins.2019.00809

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  • Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo 19F-Magnetic Resonance Spectroscopic Imaging. 査読 国際誌

    Vincent J Huber, Hironaka Igarashi, Satoshi Ueki, Mika Terumitsu-Tsujita, Chikako Nito, Ken Ohno, Yuji Suzuki, Kosuke Itoh, Ingrid L Kwee, Tsutomu Nakada

    Contrast media & molecular imaging   2019   8908943 - 8908943   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote the blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of the most severe side effects of thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes in the distribution of MMPs in the brain. Here, we developed a new 19F-molecular ligand, TGF-019, for visualizing the distribution of MMPs in vivo using 19F-magnetic resonance spectroscopic imaging (19F-MRSI). We demonstrated TGF-019 has sufficient sensitivity for the specific MMPs suspected in evoking HT during ischemic stroke, i.e., MMP2, MMP9, and MMP3. We then utilized it to assess those MMPs at 22 to 24 hours after experimental focal cerebral ischemia on MMP2-null mice, as well as wild-type mice with and without the systemic administration of the recombinant tissue plasminogen activator (rt-PA). The 19F-MRSI of TGN-019-administered mice showed high signal intensity within ischemic lesions that correlated with total MMP2 and MMP9 activity, which was confirmed by zymographic analysis of ischemic tissues. Based on the results of this study, 19F-MRSI following TGN-019 administration can be used to assess potential therapeutic strategies for ischemic stroke.

    DOI: 10.1155/2019/8908943

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  • Absolute pitch is not necessary for pitch class-color synesthesia 査読

    Kosuke Itoh, Tsutomu Nakada

    Consciousness and Cognition   65   169   2018年10月

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    出版者・発行元:Elsevier {BV}  

    DOI: 10.1016/j.concog.2018.08.010

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  • Musical pitch classes have rainbow hues in pitch class-color synesthesia 査読

    Kosuke Itoh, Honami Sakata, Ingrid L. Kwee, Tsutomu Nakada

    SCIENTIFIC REPORTS   7 ( 1 )   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Synesthesia, an anomalous blending of senses in which stimulation of one sensory modality produces sensation in a different modality, provides a unique opportunity to study how multimodal information is represented in the human brain. We investigated how pitch classes (do, re, mi, etc.) are associated with the three dimensions of color (hue, saturation, and value/brightness) in 15 subjects who possessed "pitch class-color synesthesia". Across-subject averaging of reported colors revealed that pitch classes have rainbow hues, beginning with do-red, re-yellow, and so forth, ending with si-violet, accompanied by a decrease in saturation. Enharmonic pitch classes that referred to the same pitch class with a different name produced color sensations according to the name of the base pitch class, e.g., a reddish color for do-sharp and a yellowish color for re-flat. Thus the main factor producing color sensations was the name, not the sound, of the note; behavioral experiments corroborated this interpretation. Pitch class-color synesthesia represents a newly described type of synesthesia that is distinct from the well-known crossmodal association between pitch height and value/brightness. Findings suggest that the two dimensions of musical pitch, pitch class and pitch height, are mapped to the hue-saturation plane and the value/brightness dimension of color, respectively.

    DOI: 10.1038/s41598-017-18150-y

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    その他リンク: http://orcid.org/0000-0003-0289-8048

  • Slow accumulations of neural activities in multiple cortical regions precede self-initiation of movement: An event-related fMRI study 査読

    Honami Sakata, Kosuke Itoh, Yuji Suzuki, Katsuki Nakamura, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    eNeuro   4 ( 5 )   ENEURO.0183   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Society for Neuroscience  

    The neural processes underlying self-initiated behavior (behavior that is initiated without an external stimulus trigger) are not well understood. This event-related fMRI study investigated the neural origins of self-initiated behaviors in humans, by identifying brain regions that increased in neural activities several seconds prior to self-initiated movements. Subjects performed a hand grasping task under two conditions: a free-timing and cued timing condition. The supplementary motor area (SMA) began to activate several seconds prior to self-initiated movement (accounting for hemodynamic delay), representing a potential blood oxygenation level-dependent (BOLD) signal correlate of the readiness potential (RP) on electroencephalogram (EEG), referred to here as “readiness BOLD signals.” Significant readiness BOLD signals were also observed in the right frontoparietal areas, precuneus, and insula, all of which are known to contribute to internally-generated behaviors, but with no prior evidence for such early and slow accumulation of neural activities. Moreover, visual and auditory cortices also exhibited clear readiness BOLD signals with similar early onsets, even absent external stimulation. Slow accumulation of neural activities throughout distributed cortical areas, including sensory, association, and motor cortices, underlies the generation of self-initiated behaviors. These findings warrant reconsideration of the prevailing view that the SMA or some other specific locus in frontoparietal cortex serves as the ultimate neural origin of self-initiated movement.

    DOI: 10.1523/ENEURO.0183-17.2017

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  • Evidence for cerebellar motor functional reorganization in brain tumor patients: An fMRI study 査読

    Satoshi Kurabe, Kosuke Itoh, Tsutomu Nakada, Yukihiko Fujii

    NEUROSCIENCE LETTERS   622   45 - 48   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Functional reorganization of the motor system following brain damage has been studied extensively in stroke patients, in which not only the cerebrum but also the cerebellum (CbII) undergoes substantial reorganization. However, the role of CbII in motor functional reorganization in brain tumor patients remains poorly investigated. Because brain damages in brain tumor patients occur much more slowly than in stroke patients, the neural mechanisms for motor functional reorganization might differ between these two disease conditions. This functional magnetic resonance imaging (fMRI) study investigated whether CbII constitutes the neural substrates for motor functional reorganization in eighteen supratentorial brain tumor patients who exhibited no clinical signs of paresis. The patients and normal volunteers underwent a unilateral hand movement task. In the patients, the locus of primary sensory motor (SM1) activation during contralesional hand movement was significantly displaced by the tumor, suggesting functional compromise and/or reorganization in the central sulcus region. In addition, their contralesional CbII activation during contralesional hand movement was substantially increased as compared to normal controls. The finding represents the first conclusive evidence that CbII is involved in the motor-related functional reorganization in patients with brain tumor. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.neulet.2016.04.036

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  • Noninvasive scalp recording of cortical auditory evoked potentials in the alert macaque monkey 査読

    Kosuke Itoh, Masafumi Nejime, Naho Konoike, Tsutomu Nakada, Katsuki Nakamura

    HEARING RESEARCH   327   117 - 125   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Scalp-recorded evoked potentials (EP) provide researchers and clinicians with irreplaceable means for recording stimulus-related neural activities in the human brain, due to its high temporal resolution, handiness, and, perhaps more importantly, non-invasiveness. This work recorded the scalp cortical auditory EP (CAEP) in unanesthetized monkeys by using methods that are essentially identical to those applied to humans. Young adult rhesus monkeys (Macaca mulatto, 5-7 years old) were seated in a monkey chair, and their head movements were partially restricted by polystyrene blocks and tension poles placed around their head. Individual electrodes were fixated on their scalp using collodion according to the 10-20 system. Pure tone stimuli were presented while electroencephalograms were recorded from up to nineteen channels, including an electrooculogram channel. In all monkeys (n = 3), the recorded CAEP comprised a series of positive and negative deflections, labeled here as macaque P1 (mP1), macaque N1 (mN1), macaque P2 (mP2), and macaque N2 (mN2), and these transient responses to sound onset were followed by a sustained potential that continued for the duration of the sound, labeled the macaque sustained potential (mSP). mPl, mN2 and mSP were the prominent responses, and they had maximal amplitudes over frontal/central midline electrode sites, consistent with generators in auditory cortices. The study represents the first noninvasive scalp recording of CAEP in alert rhesus monkeys, to our knowledge. (C) 2015 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.heares.2015.05.007

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  • Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death 査読

    Tetsuhiko Ikeda, Tetsuya Takahashi, Mika Tsujita, Masato Kanazawa, Masafumi Toriyabe, Misaki Koyama, Kosuke Itoh, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata

    PLOS ONE   10 ( 6 )   e0128844   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Hypoglycemic encephalopathy (HE) is caused by a lack of glucose availability to neuronal cells, and no neuroprotective drugs have been developed as yet. Studies on the pathogenesis of HE and the development of new neuroprotective drugs have been conducted using animal models such as the hypoglycemic coma model and non-coma hypoglycemia model. However, both models have inherent problems, and establishment of animal models that mimic clinical situations is desirable. In this study, we first developed a short-term hypoglycemic coma model in which rats could be maintained in an isoelectric electroencephalogram (EEG) state for 2 min and subsequent hyperglycemia without requiring anti-seizure drugs and an artificial ventilation. This condition caused the production of 4-hydroxy-2-nonenal (4-HNE), a cytotoxic aldehyde, in neurons of the hippocampus and cerebral cortex, and a marked increase in neuronal death as evaluated by Fluoro-Jade B (FJB) staining. We also investigated whether N-(1,3-benzodioxole-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1), a small-molecule agonist of aldehyde dehydrogenase-2, could attenuate 4-HNE levels and reduce hypoglycemic neuronal death. After confirming that EEG recordings remained isoelectric for 2 min, Alda-1 (8.5 mg/kg) or vehicle (dimethyl sulfoxide; DMSO) was administered intravenously with glucose to maintain a blood glucose level of 250 to 270 mg/dL. Fewer 4-HNE and FJB-positive cells were observed in the cerebral cortex of Alda-1-treated rats than in DMSO-treated rats 24 h after glucose administration (P = 0.002 and P = 0.020). Thus, activation of the ALDH2 pathway could be a molecular target for HE treatment, and Alda-1 is a potentially neuroprotective agent that exerts a beneficial effect on neurons when intravenously administered simultaneously with glucose.

    DOI: 10.1371/journal.pone.0128844

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    その他リンク: http://orcid.org/0000-0001-6337-8156

  • Further characterization of "subject's own name (SON) negativity," an ERP component reflecting early preattentive detection of SON Neuroscience 査読

    Toshihiko Tateuchi, Kosuke Itoh, Tsutomu Nakada

    BMC Research Notes   8 ( 1 )   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BioMed Central Ltd.  

    Background: Subject's own name (SON) is detected automatically and unconsciously in the brain. SON negativity, an early wave in the mismatch negativity latency range, has been proposed as a potential event-related potential (ERP) index of the automatic preattentive detection of SON. SON negativity is probably not a general measure of familiarity, as it is not elicited by the subject's parent's name. We further investigated the specificity of this response by testing whether it is elicited by a name to which subjects were strongly but only temporarily familiarized. Findings: Subjects performed a task to detect an arbitrary unfamiliar name for forty minutes. Then, that name was presented randomly and equiprobably with nine novel unfamiliar names while they played a video game and tried to ignore the sounds. SON negativity was not elicited, even when subjects spontaneously noticed hearing the familiarized name. Conclusions: The finding supports the notion that SON negativity represents a specific ERP measure of the early preattentive detection of SON, rather than a general measure of familiarity.

    DOI: 10.1186/s13104-015-1150-8

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  • Covert effects of “one drink” of alcohol on brain processes related to car driving: An event-related potential study 査読

    Neuroscience Letters   593   78 - 82   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neulet.2015.03.020

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  • 絶対音感保持者における聴覚誘発電位T-complexの左右差

    松田 将門, 伊藤 浩介, 中田 力

    臨床神経生理学   42 ( 5 )   294 - 294   2014年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • Expansion of sensorimotor cortical activation for unilateral hand motion during contralateral hand deafferentation 査読

    Satoshi Kurabe, Kosuke Itoh, Hitoshi Matsuzawa, Tsutomu Nakada, Yukihiko Fujii

    NEUROREPORT   25 ( 6 )   435 - 439   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Acute deprivation of unilateral sensory input rapidly enhances contralateral hand motor function, but the underlying mechanisms remain poorly understood. We herein used functional MRI to evaluate, in 14 healthy individuals, motor cortical activation for right finger motion before, during, and after sensory deprivation of left forearm induced by reversible, noninvasive ischemic nerve block (INB). Before INB, the motor task activated the left primary sensorimotor cortex (SM1) as expected. During INB, the volume of the left SM1 activation significantly increased, and, after INB, it returned to the pre-INB, baseline level. The effectiveness of the INB of the left forearm was ensured by confirming disappearance of the activation in right primary sensory cortex that is normally caused by tactile stimulation of the left index finger. These findings demonstrate that acute deafferentation of unilateral forearm causes rapid and reversible changes in the neural substrates for contralateral finger motion, mediated possibly by attenuation of transcallosal interhemispheric inhibition.

    DOI: 10.1097/WNR.0000000000000138

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    その他リンク: http://orcid.org/0000-0003-0289-8048

  • Human brain detects short-time nonlinear predictability in the temporal fine structure of deterministic chaotic sounds 査読

    Kosuke Itoh, Tsutomu Nakada

    PHYSICAL REVIEW E   87 ( 4 )   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER PHYSICAL SOC  

    Deterministic nonlinear dynamical processes are ubiquitous in nature. Chaotic sounds generated by such processes may appear irregular and random in waveform, but these sounds are mathematically distinguished from random stochastic sounds in that they contain deterministic short-time predictability in their temporal fine structures. We show that the human brain distinguishes deterministic chaotic sounds from spectrally matched stochastic sounds in neural processing and perception. Deterministic chaotic sounds, even without being attended to, elicited greater cerebral cortical responses than the surrogate control sounds after about 150 ms in latency after sound onset. Listeners also clearly discriminated these sounds in perception. The results support the hypothesis that the human auditory system is sensitive to the subtle short-time predictability embedded in the temporal fine structure of sounds. DOI: 10.1103/PhysRevE.87.042916

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  • Effects of ALDH2 Agonist, Alda-1, on Hypoglycemic Neuronal Death Associated with Glucose Reperfusion Injury 査読

    Tetsuhiko Ikeda, Tetsuya Takahashi, Hironaka Igarashi, Masato Kanazawa, Kosuke Itoh, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata

    NEUROLOGY   80   2013年2月

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  • Effects of musical training on the early auditory cortical representation of pitch transitions as indexed by change-N1 査読

    Kosuke Itoh, Yoko Okumiya-Kanke, Yoh Nakayama, Ingrid L. Kwee, Tsutomu Nakada

    EUROPEAN JOURNAL OF NEUROSCIENCE   36 ( 11 )   3580 - 3592   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    The effects of musical training on the early auditory cortical response to pitch transitions in music were investigated by use of the change-N1 component of auditory event-related potentials. Musicians and non-musicians were presented with music stimuli comprising a melody and a harmony under various listening conditions. First, when the subjects played a video game and were instructed to ignore the auditory stimuli, the onset of stimuli elicited a typical, fronto-central onset-N1, whereas melodic and harmonic pitch transitions within the stimuli elicited so-called change-N1s that were more posterior in scalp distribution. The pitch transition change-N1s, but not onset-N1, were enhanced in musicians. Second, when the listeners attended to the same stimuli as above to detect infrequently occurring target stimuli, the change-N1 elicited by pitch changes (in non-target stimuli) was augmented, in non-musicians only when the target was easily detectable, and in both musicians and non-musicians when it was difficult to detect. Thus, the early, obligatory cortical response to pitch transitions during passive listening was chronically enhanced by training in musicians, and, reflecting this training-induced enhancement, the task-related modulation of this response was also different between musicians and non-musicians. These results are the first to demonstrate the long-term effects of training, short-term effects of task and the effects of their interaction on the early (similar to 100-ms) cortical processing of pitch transitions in music. The scalp distributions of these enhancement effects were generally right dominant at temporal electrode sites, suggesting contributions from the radially oriented subcomponent of change-N1, namely, the Tb (N1c) wave of the T-complex.

    DOI: 10.1111/j.1460-9568.2012.08278.x

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  • Neural strategies for reading Japanese and Chinese sentences: A cross-linguistic fMRI study of character-decoding and morphosyntax 査読

    Koongliang Huang, Kosuke Itoh, Ingrid L. Kwee, Tsutomu Nakada

    NEUROPSYCHOLOGIA   50 ( 11 )   2598 - 2604   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Japanese and Chinese share virtually identical morphographic characters invented in ancient China. Whereas modern Chinese retained the original morphographic functionality of these characters (hanzi), modern Japanese utilizes these characters (kanji) as complex syllabograms. This divergence provides a unique opportunity to systematically investigate brain strategies for sentence reading in Japanese-Chinese bi-literates. Accordingly, we investigated brain activation associated with Japanese and Chinese reading in 14 native Japanese speakers literate in Mandarin and 14 native Mandarin speakers literate in Japanese using functional magnetic resonance imaging performed on a 31 system. The activation pattern exhibited clearly distinct features specific for each language. Regardless of the subject's native language literacy, Chinese reading activated an area significantly larger than Japanese reading, suggesting that brain processes involved in Chinese reading were much more complex than Japanese reading. Significant recruitment of corresponding cortical areas in the right hemisphere with Chinese reading was also apparent. The activation patterns associated with Japanese reading by native Japanese literates was highly consistent with previous reports, and included the left inferior frontal gyrus (IFG), left posterior temporal lobe (PTL), and left ventral premotor cortex (PMv). The activation pattern associated with Chinese reading by native Chinese literates was also highly consistent with previous reports, namely the left IFG, left PTL, left PMv, left anterior temporal lobe (ATL), and bilateral parieto occipital lobes (LPOL). The activation pattern associated with Chinese reading by native Japanese literates was virtually identical to that by native Chinese literates, whereas the activation pattern associated with Japanese reading by native Chinese literates was signified by additional activation of LPOL compared to that by native Japanese literate. The study indicated that IFG and PTL are universal language areas, while PMv is the area for decoding complex syllabograms. LPOL is the "Chinese language area," while ATL is essential for languages with analytic morphosyntax. (C) 2012 Elsevier Ltd. All rights reserved.

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  • Neural mechanisms underlying the orienting response to subject's own name: An event-related potential study 査読

    Toshihiko Tateuchi, Kosuke Itoh, Tsutomu Nakada

    PSYCHOPHYSIOLOGY   49 ( 6 )   786 - 791   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Neural processes underlying the orienting response (OR) to subject's own name (SON) were investigated using the oddball paradigm. Subjects were presented with SON, subject's parent's name, and unfamiliar persons' names while they played a video game and ignored the auditory stimuli. A P3a-like frontal positivity (P440, 440?ms) indexing OR was elicited by SON only when it was the rare stimulus and its amplitude decreased with the repeated presentation of SON. Preceding the P440, SON consistently elicited an early frontal negativity (SON negativity, 170270?ms), including when SON was the high-probability stimulus, and unlike the P440, this negativity did not habituate. These results conform to the hypothesis that early preattentive processing of speech sounds distinguishes SON from other names irrespective of short-term stimulus context, and that this culminates in an OR only when SON is evaluated as being contextually meaningful.

    DOI: 10.1111/j.1469-8986.2012.01363.x

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  • Functional asymmetry in primary auditory cortex for processing musical sounds: temporal pattern analysis of fMRI time series 査読

    Shuji Izumi, Kosuke Itoh, Hitoshi Matsuzawa, Sugata Takahashi, Ingrid L. Kwee, Tsutomu Nakada

    NEUROREPORT   22 ( 10 )   470 - 473   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Hemispheric differences in the temporal processing of musical sounds within the primary auditory cortex were investigated using functional magnetic resonance imaging ( fMRI) time series analysis on a 3.0 T system in right-handed individuals who had no formal training in music. The two hemispheres exhibited a clear-cut asymmetry in the time pattern of fMRI signals. A large transient signal component was observed in the left primary auditory cortex immediately after the onset of musical sounds, while only sustained activation, without an initial transient component, was seen in the right primary auditory cortex. The observed difference was believed to reflect differential segmentation in primary auditory cortical sound processing. Although the left primary auditory cortex processed the entire 30-s musical sound stimulus as a single event, the right primary auditory cortex had low-level processing of sounds with multiple segmentations of shorter time scales. The study indicated that musical sounds are processed as &apos;sounds with contents&apos;, similar to how language is processed in the left primary auditory cortex. NeuroReport 22:470-473 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

    DOI: 10.1097/WNR.0b013e3283475828

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  • Central auditory processing of noncontextual consonance in music: An evoked potential study 査読

    Kosuke Itoh, Shugo Suwazono, Tsutomu Nakada

    JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA   128 ( 6 )   3781 - 3787   2010年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACOUSTICAL SOC AMER AMER INST PHYSICS  

    The consonance of individual chords presented out of musical context, or the noncontextual consonance of chords, is usually defined as the absence of roughness, which is a sensation perceived when slightly mistuned frequencies are not clearly resolved in the cochlea. The present work uses evoked potentials to demonstrate that the absence of roughness is not sufficient to explain the entirety of noncontextual consonance perception. Presented with a random sequence of various pure-tone intervals (0-13 semitones), listeners' cerebral cortical activities distinguished these stimuli according to their noncontextual consonance in a manner consistent with standard musical practice, even when the intervals exceeded the critical bandwidth (approximately three semitones). The roughness-based model of noncontextual consonance could not account for this result because these wide intervals had indistinguishably low levels of roughness. Further, this effect was evident only in musicians, indicating plasticity in the underlying neural mechanisms. The results are consistent with the hypothesis that, although the absence of roughness may represent an important aspect of noncontextual consonance, properties of intervals other than those related to roughness also contribute to this perception, underpinned by neural activity in the central auditory system that can be plastically modified by experience. (C) 2010 Acoustical Society of America. [DOI: 10.1121/1.3500685]

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  • 両眼単一視による奥行き知覚における融像限界と視力の関係

    渡辺 将樹, 木竜 徹, 鈴木 清隆, 伊藤 浩介, 中田 力

    電子情報通信学会技術研究報告   108 ( 179 )   159 - 162   2009年3月

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  • Neural substrates for visual pattern recognition learning in Igo 査読

    Kosuke Itoh, Hideaki Kitamura, Yukihiko Fujii, Tsutomu Nakada

    BRAIN RESEARCH   1227   162 - 173   2008年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Different contexts require different visual pattern recognitions even for identical retinal inputs, and acquiring expertise in various visual-cognitive skills requires long-term training to become capable of recognizing relevant visual patterns in otherwise ambiguous stimuli. This 3-Tesla fMRI experiment exploited shikatsu-mondai (life-or-death problems) in the Oriental board game of Igo (Go) to identify the neural substrates supporting this gradual and adaptive learning. In shikatsu-mondai, the player adds stones to the board with the objective of making, or preventing the opponent from making nigan (two eyes), or the topology of figure of eight, with these stones. Without learning the game, passive viewing of shikatsu-mondai activated the occipito-temporal cortices, reflecting visual processing without the recognition of nigan. Several days after two-hour training, passive viewing of the same stimuli additionally activated the premotor area, intraparietal sulcus, and a visual area near the junction of the (left) intraparietal and transverse occipital sulci, demonstrating plastic changes in neuronal responsivity to the stimuli that contained indications of nigan. Behavioral tests confirmed that the participants had successfully learned to recognize nigan and solve the problems. in the newly activated regions, the level of neural activity while viewing the problems correlated positively with the level of achievement in learning. These results conformed to the hypothesis that recognition of a newly learned visual pattern is supported by the activities of fronto-parietal and visual cortical neurons that interact via newly formed functional connections among these regions. These connections would provide the medium by which the fronto-parietal system modulates visual cortical activity to attain behaviorally relevant perceptions. (C) 2008 Elsevier B.V. All rights reserved.

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  • Natural preference in luminosity for frame composition 査読

    Naoharu Kobayashi, Kosuke Itoh, Kiyotaka Suzuki, Ingrid L. Kwee, Tsutomu Nakada

    NEUROREPORT   18 ( 11 )   1137 - 1140   2007年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    We investigated whether or not frame composition spontaneously selected by individuals exhibit a natural left shift in preference of luminosity, as previously suggested, by examining biases in luminosity imprinted in photographs taken under three different conditions: (i) daytime pictures taken outside without determination of frame composition (N = 4153); (ii) daytime pictures taken outside with determination of frame composition (N=4035); and (iii) pictures taken inside with determination of frame composition (N=4045). As anticipated, there was a strong vertical gradient of luminance grayscale intensity, reflecting natural day light distribution, for pictures of categories (i) and (ii). Similarly, a minor vertical gradient was detected for pictures of category (iii), indicating common room lighting conditions. To our great interest, there was a consistent leftward tilt of ca. 2 and 9 degrees found in the vertical gradients for pictures of categories (ii) and (iii), respectively, but not for pictures of category (i). The result provides clear-cut evidence that there is indeed a natural preference for a leftward bias in luminosity for frame composition.

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  • Electrophysiological correlates of absolute pitch and relative pitch 査読

    K Itoh, S Suwazono, H Arao, K Miyazaki, T Nakada

    CEREBRAL CORTEX   15 ( 6 )   760 - 769   2005年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    The temporal and spatial characteristics of the cortical processes responsible for absolute pitch (AP) and relative pitch (RP) were investigated by multi-channel event-related potentials (ERPs). Compared to listening, pitch-naming of tones in non-possessors of AP elicited three ERP components (P3b, parietal positive slow wave, frontal negative slow wave) over parietal and frontal scalp between 300 and 900 ms in latency, representing the cortical processes for RP. Possessors of AP elicited a unique left posterior-temporal negativity ('AP negativity') at 150 ms in both listening and pitch-naming conditions, representing the cortical processes for AP that were triggered by pitch input irrespective of the task the subjects were asked to perform. Congruency of auditory Stroop stimuli modulated the amplitudes of parietal positive slow wave (non-possessors of AP) and 'AP negativity' (possessors of AP), confirming that these components reflect the verbal labeling or pitch-to-pitch-name associative transformation that is central to pitch-naming. These results are consistent with the hypothesis that AP is subserved by neuronal processes in the left auditory association cortex that occur earlier and more automatically than the processes for RP, which involve broader areas of the cortex over longer periods of time.

    DOI: 10.1093/cercor/bhh177

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  • Affiliative bonding as a dynamical process: A view from ethology 査読

    K Itoh, A Izumi

    BEHAVIORAL AND BRAIN SCIENCES   28 ( 3 )   355 - +   2005年6月

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    記述言語:英語   出版者・発行元:CAMBRIDGE UNIV PRESS  

    Depue & Morrone-Strupinsky's (D&M-Ss) implicit assumption appears to be that affiliative bonding is either strengthened or maintained with time; however, it is more realistic that it can also be weakened or destroyed by conflictive interpersonal interactions. Without specifying the mechanisms by which antagonistic stimuli deteriorate affiliative bonding, the model is incapable of accounting for the dynamics associated with this complex phenomenon.

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  • MT+/V5 activation without conscious motion perception: A high-field fMRI study 査読

    Kosuke Itoh, Yukihiko Fujii, Ingrid L. Kwee, Tsutomu Nakada

    Magnetic Resonance in Medical Sciences   4 ( 2 )   69 - 74   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    While activity of MT+/V5 neurons is believed to be necessary for the conscious perception of visual motion, whether neural activity in MT+/V5 is a sufficient condition for the conscious perception of motion in vision still remains unanswered. A high-field (3.0 Tesla) functional magnetic resonance imaging (fMRI) study was designed and performed to answer this specific question. Eleven healthy subjects viewed a checkerboard pattern stimulus reversed in contrast at 0.2, 12, 30, and 60 Hz while being probed for activation in MT+/V5. At 0.2 Hz, all viewers perceived pattern-reversal which was stationary in position. However, at 12, 30, and 60 Hz, many subjects perceived apparent motion (e.g., vertical and horizontal flows) in the square pattern. At 12 and 30 Hz reversals, MT+/V5 was activated in all subjects (11/11). Nevertheless, three out of eleven (3/11) subjects denied motion perception in these conditions. At 60 Hz reversal, as many as seven out of eleven (7/11) subjects failed to see motion but activation in MT+/V5 was found in the majority (5/7) of the subjects. The results demonstrated that significant MT+/V5 activation occurs without accompanying subjective awareness of seeing motion in an apparent-motion stimulus, indicating that neural activity in MT+/V5 does not represent a sufficient condition for conscious perception of motion in vision. © 2005 by Japanese Society for Magnetic Resonance in Medicine.

    DOI: 10.2463/mrms.4.69

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  • Personality research with non-human primates: theoretical formulation and methods (vol 43, pg 249, 2002) 査読

    K Itoh

    PRIMATES   45 ( 4 )   285 - 285   2004年10月

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    記述言語:英語   出版者・発行元:SPRINGER TOKYO  

    DOI: 10.1007/s10329-004-0105-9

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  • Electrophysiological correlates of grapheme-phoneme conversion 査読

    K Huang, K Itoh, S Suwazono, T Nakada

    NEUROSCIENCE LETTERS   366 ( 3 )   254 - 258   2004年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    The cortical processes underlying grapheme-phoneme conversion were investigated by event-related potentials (ERPs). The task consisted of silent reading or vowel-matching of three Japanese hiragana characters, each representing a consonant-vowel syllable. At earlier latencies, typical components of the visual ERP, namely, P1 (110 ms), NI (170 ms) and P2 (300 ms), were elicited in the temporo-occipital area for both tasks as well as control task (observing the orthographic shapes of three Korean characters). Following these earlier components, two sustained negativities were identified. The earlier sustained negativity, referred here to as SN1, was found in both the silent-reading and vowel-matching task but not in the control task. The scalp distribution of SN1 was over the left occipito-temporal area, with maximum amplitude over O1. The amplitude of SN1 was larger in the vowel-matching task compared to the silent-reading task, consistent with previous reports that ERP amplitude correlates with task difficulty. SN2, the later sustained negativity, was only observed in the vowel-matching task. The scalp distribution of SN2 was over the midsagittal centro-parietal area with maximum amplitude over Cz. Elicitation of SN2 in the vowel-matching task suggested that the vowel-matching task requires a wider range of neural activities exceeding the established conventional area of language processing. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

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  • 聴覚ストループ効果における干渉パターンの検討

    荒生 弘史, 伊藤 浩介, 諏訪園 秀吾, 中田 力, 宮崎 謙一

    日本認知心理学会発表論文集   2004   56 - 56   2004年

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    記述言語:日本語   出版者・発行元:日本認知心理学会  

    DOI: 10.14875/cogpsy.2004.0.056.0

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  • Cortical processing of musical consonance: an evoked potential study 査読

    K Itoh, S Suwazono, T Nakada

    NEUROREPORT   14 ( 18 )   2303 - 2306   2003年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    dCortical processes underlying perception of musical consonance were investigated by long-latency auditory evoked potentials (EPs). Subjects listened to a random sequence of dyadic pure tones paired at various pitch intervals (1, 4, 6, 7, or 9 semitones). Amplitudes of P2 and N2 components of auditory EPs were significantly modulated by pitch interval of the dyads, being most negative for 1 semitone (minor second) and least negative or most positive for 7 semitones (perfect fifth). The results indicate that neural processing of consonance depend not only on peripheral mechanisms in the inner ear but also on higher associative processing of pitch relationships in the cerebral cortex. (C) 2003 Lippincott Williams Wilkins.

    DOI: 10.1097/01.wnr.0000099989.54721.75

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  • Ear advantage and consonance of dichotic pitch intervals in absolute-pitch possessors 査読

    K Itoh, K Miyazaki, T Nakada

    BRAIN AND COGNITION   53 ( 3 )   464 - 471   2003年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Left-right asymmetry in the central processing of musical consonance was investigated by dichotic listening tasks. Two piano tones paired at various pitch intervals (1-11 semitones) were presented one note in each ear to twenty absolute-pitch possessors. As a result, a weak overall trend for left ear advantage (LEA) was found, as is characteristic of trained musicians. Second, pitches of dissonant intervals were more difficult to identify than those of consonant intervals. Finally, the LEA was greater with dissonant intervals than with consonant intervals. As the tones were dichotically presented, the results indicated that the central auditory system could distinguish between consonant and dissonant intervals without initial processing of pitch-pitch relations in the cochlea. (C) 2003 Elsevier Inc. All rights reserved.

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  • Personality research with non-human primates: Theoretical formulation and methods 査読

    K Itoh

    PRIMATES   43 ( 3 )   249 - 261   2002年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER-VERLAG TOKYO  

    Since the earliest periods of primatology study, researchers have been aware of animals' consistent individual differences in behavior or personality. Many papers have been published on this subject, but they lacked a common theoretical and methodological background. The present work is an attempt to provide such theoretical and methodological foundations to this field of biological science. In the theoretical formulation section, "biological study of personality" is first derived as an extension of the ethology paradigm, and non-human primate personality research is subsequently characterized as its strategic component. In the methodology section, brief reviews and discussions are presented on subjective and objective personality assessment methods with non-human primates with a reference to the reliability and validity concepts in human psychometrics. The work provides a theoretical framework and methodological suggestions for non-human primate personality research.

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  • Asymmetry of parietal lobe activation during piano performance: a high field functional magnetic resonance imaging study 査読

    K Itoh, Y Fujii, K Suzuki, T Nakada

    NEUROSCIENCE LETTERS   309 ( 1 )   41 - 44   2001年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    Functional asymmetry of the parietal lobes during piano performance was assessed utilizing independent component cross-correlation-sequential epoch analysis of functional magnetic resonance imaging time series. Eight right handed musically trained subjects played the piano with their right hand, left hand, or both hands as cued by visually presented musical scores. The areas activated included the posterior parietal cortex (PPC) and the primary sensorimotor areas (SM1). While unilateral SM1 activation was correlated to motion of the corresponding contralateral hand, PPC activation was correlated to piano performance irrespective of hand modality. Furthermore, PPC activation exhibited significant asymmetry, with left hemisphere dominance. The results indicate that the left parietal lobe plays a significant role in the cortical processes of piano performance. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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  • Object discrimination learning in aged Japanese monkeys 査読

    K Itoh, A Izumi, S Kojima

    BEHAVIORAL NEUROSCIENCE   115 ( 2 )   259 - 270   2001年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER PSYCHOLOGICAL ASSOC  

    The authors investigated the behavioral aging effects of Japanese macaques in 3 object discrimination learning tasks: learning-set (LS) formation, go/no-go discrimination learning, and multiple discrimination reversals. Aged monkeys showed deteriorated performance in these tasks compared with younger controls, Hypothesis analysis of LS showed that aged monkeys had difficulty learning the lose-shift component of the hypothesis win-stay-lose-shift with respect to object. Deficits in go/no-go successive discrimination were clear in no-go trials only in the first 2 pairs of 5 tasks. Performance of aged monkeys was severely disturbed from a chance to criterion level in discrimination reversals. These results are attributed not only to increased tendency for perseveration but also to difficulty in associating the reward and the object in aged monkeys and may be related to the decline in the functions of the ventral frontal cortex.

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  • Assessment of individual differences in the preferred proximity to a human feeder by partitioned raisin test, with two species of macaque monkeys 査読

    K Itoh

    PRIMATES   42 ( 1 )   47 - 56   2001年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER TOKYO  

    All animals must acquire food and mates by approaching them despite possibilities of accompanying risks and thus are frequently encountered with approach-avoidance conflicts in daily lives. Behavioral individual differences in such situations may be considered as one of the most biologically fundamental personality traits. "Partitioned raisin test" was devised to assess this trait with macaque monkeys. It involved throwing, raisins into groups of monkeys and observing the preferred distance of each from the human feeder, a source of possible harm. The test was administered to 4 groups of Japanese monkeys (30 total) and 3 groups of rhesus monkeys (19 total), all 1-yr-old and matched in history. Individual differences in the preferred proximity to the feeder, as expressed by the Proximity Index (PI), were found in both species, PI was not correlated with a measure of dominance over the raisins. Individual differences in PI were also not due to territorial effects unrelated to the location of the feeder. PI was stable in five of the six monkeys re-tested after one year of interval in a newly organized group, where there supposedly had been a change in their social structure. Partitioned raisin test was shown to be capable of depicting individual differences related to differential approach bias in an approach-avoidance conflict situation. Although possible confounding effects by social factors need to be delineated in the following studies, the method may provide a handy and widely applicable way for the assessment of this trait with monkeys.

    DOI: 10.1007/BF02640688

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    その他リンク: http://orcid.org/0000-0003-0289-8048

  • 老齢ザルの認知機能に関する研究

    落合 牧子, 伊藤 浩介, 泉 明宏, 小嶋 祥三

    霊長類研究 = Primate research   14 ( 2 )   95 - 102   1998年8月

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    記述言語:日本語   出版者・発行元:Primate Society of Japan  

    DOI: 10.2354/psj.14.95

    CiNii Article

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    その他リンク: https://jlc.jst.go.jp/DN/JALC/00341033095?from=CiNii

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書籍等出版物

  • 絶対音感を科学する

    阿部 純一, 宮崎 謙一, 榊原 彩子( 担当: 共著 ,  範囲: 絶対音感と脳)

    全音楽譜出版社  2021年5月  ( ISBN:4118800519

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    総ページ数:296   記述言語:日本語

    CiNii Books

    ASIN

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  • ドレミファソラシは虹の七色? : 知られざる「共感覚」の世界

    伊藤, 浩介

    光文社  2021年3月  ( ISBN:9784334045302

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    総ページ数:244p, 図版 [8] p   記述言語:日本語

    CiNii Books

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MISC

  • コモンマーモセットにおける頭皮上聴覚誘発電位の無麻酔・無侵襲記録 国際誌

    伊藤浩介, 岩沖晴彦, 鴻池菜保, 五十嵐博中, 中村克樹

    第42回日本神経科学会大会   405   108229 - 108229   2021年6月

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  • 絶対音感保持者における音階音と非音階音に対するミスマッチ陰性電位

    松田 将門, 伊藤 浩介, 五十嵐 博中

    臨床神経生理学   47 ( 5 )   427 - 427   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

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  • 自己開始運動に先行する自発的脳活動 査読

    Honami Sakata, Kosuke Itoh, Yuji Suzuki, Katsuki Nakamura, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    NEURO2019大会(第42回日本神経科学大会)   2019年7月

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  • コモンマーモセットにおける聴覚情報処理に関わる神経応答

    鴻池菜保, 三輪美樹, 伊藤浩介, 中村克樹

    第42回日本神経科学会大会   2019年7月

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  • 内因性の意図に基づく自己開始運動に先行する脳活動

    酒多 穂波, 伊藤 浩介, 鈴木 雄治, 中村 克樹, 渡辺 将樹, 五十嵐 博中, 中田 力

    基礎心理学研究   37 ( 2 )   222 - 222   2019年3月

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    記述言語:日本語   出版者・発行元:日本基礎心理学会  

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  • 聴覚機能の進化:ヒトとアカゲザルにおける無侵襲頭皮上聴覚誘発電位記録による検討

    伊藤浩介, 禰占雅史, 鴻池菜保, 中田力, 中村克樹

    日本基礎心理学会第36回大会   2017年12月

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  • Endogenously initiated movements are preceded by neural activities in multiple cortical regions: an event-related fMRI study 査読

    Honami Sakata, Kosuke Itoh, Yuji Suzuki, Katsuki Nakamura, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    47th Annual meeting of Society for Neuroscience   2017年11月

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  • Musical chord change detection in the macaque monkey is hindered by insertion of silent gaps between chords: a scalp ERP study

    Kosuke Itoh, Masafumi Nejime, Naho Konoike, Katsuki Nakamura, Tsutomu Nakada

    The 47th annual meeting of Society for Neuroscience   2017年11月

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  • 内因性の意図に基づく運動に先行する神経活動

    酒多穂波, 伊藤浩介, 鈴木雄治, 中村克樹, 渡辺将樹, 五十嵐博中, 中田力

    第29回 臨床MR脳機能研究   2017年4月

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  • 事象関連fMRIによる自由な意図の神経基盤の検討

    酒多穂波, 伊藤浩介, 鈴木雄治, 中村克樹, 渡辺将樹, 五十嵐博中, 中田力

    第6回 生理研-霊長研-脳研 合同シンポジウム   2017年3月

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  • Evolutionary elongation of the time scale of auditory cortical processing: comparison of effects of stimulus time parameters on human and macaque scalp auditory evoked potentials. 査読

    Itoh K, Nejime M, Konoike N, Nakamura K, Nakada T

    The 5th Joint Meeting of Acoustical Society of America and Acoustical Society of Japan   2016年11月

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    記述言語:英語  

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  • 無麻酔アカゲザルにおける頭皮上聴覚誘発電位の長潜時成分:記録法と成分同定

    伊藤浩介, 禰占雅史, 鴻池菜保, 中田力, 中村克樹

    臨床神経生理学   44 ( 5 )   462   2016年10月

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    記述言語:日本語  

    J-GLOBAL

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  • アカゲザルにおける聴覚誘発電位長潜時成分:記録法と成分同定 査読

    伊藤浩介, 禰占雅史, 鴻池菜保, 中田力, 中村克樹

    第46回日本臨床神経生理学会学術大会   2016年10月

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    記述言語:日本語  

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  • マウスVBM用のMRI標準脳の開発とアルツハイマー病モデルマウスを用いたVBMの有用性の検証

    八木 悠太, 植木 智志, 伊藤 浩介, 辻田 実加, 五十嵐 博中, 大久保 真樹

    日本放射線技術学会雑誌   71 ( 9 )   932 - 933   2015年9月

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    記述言語:日本語   出版者・発行元:(公社)日本放射線技術学会  

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  • SON negativity: An event-related potential component reflecting preattentive detection of subject's own name (SON)

    Kosuke Itoh, Toshihiko Tateuchi, Tsutomu Nakada

    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY   94 ( 2 )   150 - 150   2014年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.ijpsycho.2014.08.675

    Web of Science

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  • 6 Modulation of cortical motor network : An fMRI study(Ⅰ.一般演題, 第62回新潟脳神経外科懇話会)

    倉部 聡, 伊藤 浩介, 松澤 等, 中田 力, 藤井 幸彦

    新潟医学会雑誌   128 ( 11 )   610 - 611   2014年11月

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    記述言語:日本語   出版者・発行元:新潟医学会  

    CiNii Article

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    その他リンク: http://search.jamas.or.jp/link/ui/2015187841

  • 低血糖脳症におけるグルコース再灌流障害を標的とした新規神経保護薬の検討

    池田 哲彦, 高橋 哲哉, 五十嵐 博中, 金澤 雅人, 伊藤 浩介, 中田 力, 西澤 正豊, 下畑 享良

    臨床神経学   53 ( 12 )   1539 - 1539   2013年12月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • 歌声による聴覚ストループ干渉

    荒生 弘史, 伊藤 浩介, 諏訪園 秀吾, 中田 力, 宮崎 謙一

    電子情報通信学会技術研究報告. HIP, ヒューマン情報処理   102 ( 533 )   1 - 6   2002年12月

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    記述言語:英語   出版者・発行元:一般社団法人電子情報通信学会  

    簡単な実験手法により,聴覚におけるストループ干渉を示した.刺激は,九つのピッチ-シラブルの組み合わせであった.ド,レ,ミの三つのシラブルのそれぞれが,C3,D3,E3の各々のピッチで歌われたものである.例えば,C3-ドは一致刺激,C3-レは不一致刺激である.聴取者の絶対音感の有無に関わらず,ピッチについて反応する際には,不一致のシラブルによる干渉がみられた.シラブルについて反応する際には,絶対音感を有する被験者に限り,不一致のピッチによる干渉がみられた.すなわち,双方向性の干渉パターンが絶対音感を有する聴取者に,片側方向性の干渉パターンが絶対音感を有しない聴取者にみられた.この結果は,先行研究(Miyazaki,2000)と一致している.絶対音感保持者のピッチ処理や,ストループ干渉のモデルに関する示唆を議論した.

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共同研究・競争的資金等の研究

  • ヒトとサルで「社会脳」の機構や進化を調べる次世代ハイパースキャニング脳波計の開発

    研究課題/領域番号:22K18644  2022年6月 - 2024年3月

    日本学術振興会  科学研究費助成事業 挑戦的研究(萌芽)  挑戦的研究(萌芽)

    伊藤 浩介, 鴻池 菜保

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    配分額:6500000円 ( 直接経費:5000000円 、 間接経費:1500000円 )

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  • 脳の時間の単位の進化:哺乳類6種における無侵襲脳波記録による検討

    研究課題/領域番号:21H00304  2021年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

    伊藤 浩介

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    配分額:5200000円 ( 直接経費:4000000円 、 間接経費:1200000円 )

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  • イルカ無侵襲脳波記録への挑戦

    研究課題/領域番号:20K21559  2020年7月 - 2022年3月

    日本学術振興会  科学研究費助成事業 挑戦的研究(萌芽)  挑戦的研究(萌芽)

    伊藤 浩介

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    配分額:6500000円 ( 直接経費:5000000円 、 間接経費:1500000円 )

    イルカは、霊長類とは全く異なる進化の道をたどることで、高度に発達した脳を持つに至った。しかし、そのようなイ
    ルカの脳の構造や機能は、驚くほど霊長類とは異なる。とすると、これまで暗黙の前提だった霊長類脳の基本構造や機能は、ヒト脳の高次機能に必須の条件ではないかもしれないと思えてくる。イルカの脳には、脳の基本原理を新しい角度から照らし直す、新知見の宝庫の期待がかかる。
    しかし、生きたイルカの脳を調べる手段がない。そこで本研究は、水中のイルカから無麻酔かつ無侵襲で脳波を記録する技術を確立することで、イルカ脳科学への道を切り開くことに挑戦する。
    本研究の技術的な中核は、吸盤電極とアクティブ電極を合体させた“吸盤アクティブ電極”の新開発である。水中でのイルカの脳波記録には、吸盤による電極の設置が有効なことが示されている(Nachtigall, 2007など)。アクティブ電極は、電極部に増幅器を組み込むことで体動やリード線の動揺によるノイズの混入を防ぐ技術であり、ヒトの脳波記録で実用化されている。この2つの既存技術を組み合わせたものが、本研究に独自の“吸盤アクティブ電極”である。これにより、ノイズの少ない高品質の脳波データが、水中のイルカから無侵襲で記録できる。

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  • 遺伝子改変を用いないサル精神疾患モデルの作出と脳機能異常の解明

    研究課題/領域番号:19H01039  2019年4月 - 2024年3月

    日本学術振興会  科学研究費助成事業 基盤研究(A)  基盤研究(A)

    中村 克樹, 伊藤 浩介

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    配分額:39650000円 ( 直接経費:30500000円 、 間接経費:9150000円 )

    新生児期の炎症性サイトカイン暴露により引き起こされる行動および脳機能異常を定量的に評価し、健常個体と比較することにより、その異常の原因を明らかにし、精神疾患モデルとして確立する。具体的には、1)特に前頭前野機能を必要とする認知課題の成績、2)アイコンタクトと眼球運動、3)聴覚驚愕反応を用いたPPI、4)サーカディアンリズムと活動量、5)ECoGや聴性定常脳波(ASSR)の周波数成分、6)MRIを用いた形態画像および拡散強調 (DTI)画像の発達的変化、 7)MRIを用いた機能的ネットワーク、8)PETを用いた前頭前野の活動とドーパミン系の活性度を定量化し、健常個体と比較することを計画している。また、同種他個体と対面する場面を設定して出会い場面における他個体に対する社会行動も
    評価する。
    2020年度も研究協力者との連携体制を堅持しながら研究を進めた。マカクザルに関しては、産期に合わせた計画的なサイトカイン暴露が必要であるため、飼育担当部署と連携を取りながらアカゲザル1頭に新たにサイトカイン暴露を実施することによりモデル作出を実施した。
    マーモセットを対象として、前頭前野機能を必要とする認知課題の実施、ECoGや聴性定常脳波(ASSR)の周波数成分、MRIを用いた形態画像および拡散強調 (DTI)画像の発達的変化を重点的に解析した。マーモセットに関しては、集団内における行動異常を評価するため家族飼育が可能なケージを導入し、集団のビデオ録画や音声録音のビッグデータを収集し、集団内における社会行動の解析を進める環境を整備した。
    またマカクザルにおいても認知課題の実施、ECoGや聴性定常脳波(ASSR)の周波数成分の解析を進めた。
    データ解析や解釈に関しては、新潟大学の那波宏之教授、東北大学の川島隆太教授、新潟大学の伊藤浩介准教授と京都大学の鴻池菜保助教にアドバイスや協力を受けながら進めた。

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  • 共感覚に関する認知心理学的研究の深化と展開

    研究課題/領域番号:19H01770  2019年4月 - 2022年3月

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    横澤 一彦, 伊藤 浩介, 浅野 倫子

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    配分額:17290000円 ( 直接経費:13300000円 、 間接経費:3990000円 )

    色字共感覚では一般的に、未知の文字には色を感じないが、「その新奇文字は既知文字のAに相当する」のように既知文字に対応づけて学習させると、すぐに既知文字の共感覚色が転移する形で新奇文字に色を感じるようになることが知られていた。そこで、色字共感覚の保持者に新奇文字(未知のタイ文字)を提示し、それぞれに異なる既知文字(平仮名)を1 文字ずつ対応づけて学習させた結果、既知文字の共感覚色が互いに異なる色であった場合に比べて、既知文字すべてが似た共感覚色を持つ場合は転移が起こりにくいことが分かり、共感覚色が文字の学習時に文字の弁別に使われ、学習を補助するという仮説と整合的な結果であり、Psychonomic Bulletin & Review誌の論文として採択された。色字共感覚の長期安定性の研究に取り組み、5~8年の期間を挟んだ色字対応づけの安定性のデータを収集中である。色聴共感覚の実験研究を行うとともに、共感覚と感覚間協応の関係、色聴共感覚と絶対音感の関係についても実験研究を行い、学会発表を行った。
    序数擬人化共感覚について、大学生を対象に調査を行い、この種類の共感覚を持つ人、持たない人以外に、以前は持っていたが失ったと自覚している人が少数ながら一定数存在することを確認した。そして、これらの3グループそれぞれの人における数字とパーソナリティの対応付けかたの性質について明らかにするための予備的な実験を行った。
    ドレミファソラシに色を感じる共感覚につき、新規の被験者をリクルートし、絶対音感との関係などについて、行動学的な調査を行った。また、絶対音感の脳メカニズムについて、脳波により検討を行った。さらに、マルチメディア刺激を提示することで色聴などの共感覚をインターネット上でオンライン調査するためのプラットフォームを開発した。

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  • 脳の時間の単位の進化:ヒト・サル・イルカの無侵襲脳波記録による検討

    研究課題/領域番号:19H05309  2019年4月 - 2021年3月

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

    伊藤 浩介

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    配分額:5980000円 ( 直接経費:4600000円 、 間接経費:1380000円 )

    脳が外界を知覚する、まさにその機能が、脳の時間の最小単位を規定する。例えば聴覚では、数100ミリ秒の時間窓(時間幅)が単位となり、この時間窓内の刺激は、ひとつの聴覚イベントに統合されて聞こえる。この時間窓の長さには種差があっても、不思議ではない。そして、もし感覚野の知覚処理に時間窓の種差があるならば、感覚野から情報を受ける連合野や他の脳部位にも、それに応じた時間窓の種差があるはずである。つまり、外界情報の知覚を規定する境界条件としての時間窓は、いわば、脳の時間の単位や秒針のようなものと言える。そのため、知覚の時間窓が進化でどのように変化したか(あるいはしなかったか)は、脳の時間の種差を考える上で、極めて根本的な問題である。
    しかし、知覚の時間窓に種差があるかもしれないという可能性そのものが、これまでほとんど検討されたことがない。そこで本研究は、ヒト、マカクザル、マーモセット、そしてイルカを対象とした比較研究により、時間処理がとくに重要な聴覚に注目し、脳の知覚の時間窓の進化を明らかにすることを目的とした。脳活動の指標には、頭皮上から無侵襲で記録できる、聴覚誘発電位(AEP)を利用する。
    本年度の研究では、持続時間を様々に変えた時のAEP振幅の変化を調べることで、ヒトとアカゲザルで聴覚処理の時間特性に種差があることを明らかにした(Itoh et al., 2019)。また、マーモセットの無侵襲AEP波形の形状や潜時を世界で初めて記載し(Itoh et al., submitted)、ヒト・アカゲザル・マーモセットの3種での時間窓の種差の解析を進めている。さらに、イルカで脳波記録を行うためのプロトコルやデバイス(電極シート)の作成を行った。

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  • 聴覚の時間窓の進化: 事象関連電位による比較研究

    研究課題/領域番号:17K00202  2017年4月 - 2020年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    伊藤 浩介, 酒多 穂波, 松田 将門

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    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    物理的な時間と異なり、脳が刻む時間には、時間窓(時間幅)という制約がある。時間窓は、蝸牛神経核から大脳新皮質までを含む中枢聴覚系の複雑な機能で、言語や音楽の聴覚に甚大な影響がある。聴覚の時間窓が、進化の過程でこれがどの程度保存され、あるいは変化したかは、これまでほとんど調べられていない。
    そこで本研究は、聴覚の時間窓が、ヒト進化の過程でどのように変化したのかを、ヒト・アカゲザル・コモンマーモセットの3種比較により明らかにした。

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  • 音楽の進化心理学:事象関連電位研究

    研究課題/領域番号:25540052  2013年4月 - 2017年3月

    日本学術振興会  科学研究費助成事業 挑戦的萌芽研究  挑戦的萌芽研究

    伊藤 浩介, 中村 克樹, 鴻池 菜保, 禰占 雅史, 中田 力

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    配分額:3640000円 ( 直接経費:2800000円 、 間接経費:840000円 )

    "No music, no life" などいう言葉があるが、言語や他の高次脳機能と異なり明らかな適応的意義の見当たらない音楽が、何故どのように進化したのかは不明である。本研究は、霊長類における音楽の進化を調べるために、頭皮上誘発電位(ERP)記録というこの研究分野において新しい方法論を導入し有用性を検討した。様々な音刺激に対するERPをヒトとサルで比較したところ、聴覚野においける音処理の時間スケールがヒトにおいて延長していることを示唆する結果が得られた。

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  • 機能的磁気共鳴画像を用いたヒト脳の音楽機能の研究

    研究課題/領域番号:00J81903  2000年 - 2001年

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    伊藤 浩介

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    配分額:2400000円 ( 直接経費:2400000円 )

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  • 霊長類の性格の生物学的研究

    研究課題/領域番号:97J03321  1998年 - 1999年

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    伊藤 浩介

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    配分額:1800000円 ( 直接経費:1800000円 )

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担当経験のある授業科目

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