Personnel Information




Institute of Medicine and Dentistry



Laboratory Address

2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514

Research Fields, Keywords

Tooth Developmental Biology, Pulp Biology, Mineralized Tissue, Oral Anatomy, Dental Implantology

Mail Address

E-mail address

Laboratory Phone number


Laboratory Fax number


Homepage URL


The major research subjects are pulp biology and tooth detvelopmental biology. My research goal is that our research results contribute to realize the regenerative medicine for tooth and its supporing tissues on the basis of clarification of the mechanisms regulating tooth development and pulpal healing following tooth injuries.

Graduating School 【 display / non-display

  • Niigata University, Faculty of Dentistry

    University, 1987.03, Graduated, JAPAN

Graduate School 【 display / non-display

  • Niigata University, Graduate School, Division of Dental Research

    Doctor's Course, 1991.03, Completed, JAPAN

Degree 【 display / non-display

  • Doctor of Dental Science, Morphological basic dentistry, Niigata University, Coursework, 1991.03

Campus Career 【 display / non-display

  • Niigata University Faculty of Dentistry, Assistant, 1992.12 - 1996.12

  • Niigata University Faculty of Dentistry, Lecturer, 1997.01 - 1998.03

  • Niigata University Faculty of Dentistry, Associate Professor (as old post name), 1998.04 - 2001.12

  • Niigata University Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction, Professor, 2002.01 -

  • Niigata University Faculty of Dentistry School of Dentistry, Professor, 2002.01 -

External Career 【 display / non-display

  • Hasegawa Dental Clinic, dentist, 1991.04 - 1992.11

  • University of Helsinki, Visiting fellow granted by the overseas research allowance (scholarship) by the Ministry of Education, Science, Sports and Culture of the Japanese Government, 1997.03 - 1997.12

Academic Society Affiliations 【 display / non-display

  • Niigata Dental Society, 1987.04 - , JAPAN

  • The Japanese Association of Anatomists , 1987.04 - , JAPAN

  • Japanese Association for Oral Biology, 1987.04 - , JAPAN

  • International Association for Dental Research (IADR), 1992.04 - , UNITED STATES

  • Japanese Association for Dental Research (JADR), 1992.04 - , JAPAN

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Field of expertise (Grants-in-aid for Scientific Research classification) 【 display / non-display

  • Morphological basic dentistry

Qualification acquired 【 display / non-display

  • Dentist


Research Career 【 display / non-display

  • Tooth Developmental Biology, 1997.04 -

    Epithelial Mesenchymal Interaction, Dentinogenesis, Amelogenesis,Morphological basic dentistry, International Collaboration, Grant-in-Aid for Scientific Research

  • Immune-defense Mechanism of Dental Pulp, 1992.04 -

    Dental pulp, Dendritic cells, Macrophages,Morphological basic dentistry, Individual, Grant-in-Aid for Scientific Research

  • Development and Regeneration of Dentin-pulp Complex, 1987.04 -

    Dentin-pulp Complex, Odontoblasts, Regeneration,Morphological basic dentistry, Individual, Grant-in-Aid for Scientific Research

Papers 【 display / non-display

  • The putative role of insulin-like growth factor (IGF)-binding protein 5 independent of IGF in the maintenance of pulpal homeostasis in mice., Saito K, Ohshima H, Regenerative therapy, Vol.11, pp.217-224, 2019.12, Other

    DOI:10.1016/j.reth.2019.08.001, Research paper (scientific journal), Joint Work

  • A Horizontal Sequential Cutting Method to Estimate the Effectiveness of Dentin Disinfection by Using Confocal Laser Scanning Microscopy., Hasegawa T, Takenaka S, Wakamatsu R, Ohsumi T, Domon H, Ohshima H, Terao Y, Noiri Y, Journal of endodontics, Vol.45, No.9, pp.1142-1147, 2019.09, Other

    DOI:10.1016/j.joen.2019.06.004, Research paper (scientific journal), Joint Work

  • Reduced enamel epithelium-derived cell niche in the junctional epithelium are maintained for a long time in mice., Soda M, Saito K, Ida-Yonemochi H, Nakakura-Ohshima K, Kenmotsu S, Ohshima H, Journal of periodontology, 2019.09, Other

    DOI:10.1002/JPER.19-0269, Research paper (scientific journal), Joint Work

  • Regulation of IGF-I by IGFBP3 and IGFBP5 during odontoblast differentiation in mice., Aizawa C, Saito K, Ohshima H, Journal of oral biosciences, Vol.61, No.3, pp.157-162, 2019.09, Other

    DOI:10.1016/j.job.2019.07.001, Research paper (scientific journal), Joint Work

  • Extracellular enzymatically synthesized glycogen promotes osteogenesis by activating osteoblast differentiation via Akt/GSK-3β signaling pathway., Ida-Yonemochi H, Nakagawa E, Takata H, Furuyashiki T, Kakutani R, Tanaka M, Ohshima H, Journal of cellular physiology, Vol.234, No.8, pp.13602-13616, 2019.08, Other

    DOI:10.1002/jcp.28039, Research paper (scientific journal), Joint Work

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Review Papers 【 display / non-display

  • New hypothesis on the mechanisms regulating the pulpal healing process following tooth injuries, Hayato Ohshima, Niigata Dental Society, Niigata Dent J, Vol.39, No.1, pp.171-176, 2009.12, Japanese

    Introduction and explanation (others), Single Work

  • New perspectives on tooth development and dental stem cell niche., Harada H, Ohshima H, Arch Histol Cytol, Vol.67, No.1, pp.1-11, 2004.03, English

    Introduction and explanation (scientific journal), Joint Work

Other research activities 【 display / non-display

  • Journal of Oral Biosciences Editor-in-Chief, 2009.04 -


  • Japanese Association for Oral Biology, Executive Director, 2009.04 -


  • Journal of Oral Biosciences, Editor, 2006.04 - 2009.03


  • Community for Research & Industry Cooperation of Regenerative Dentistry, 2005.10 -


  • Consortium for Tooth Regeneration, 2005.07 -


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Grant-in-Aid for Scientific Research 【 display / non-display

  • Grant-in-Aid for Scientific Research(B),2013.04 - 2016

  • Grant-in-Aid for Scientific Research(B),2013.04 - 2015

  • Grant-in-Aid for Scientific Research(C),2013.04 - 2015

  • Grant-in-Aid for Scientific Research(C),2013.04 - 2015

  • Grant-in-Aid for challenging Exploratory Research,2013.04 - 2014

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