Updated on 2023/02/05

写真a

 
TUCHIDA Masanori
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Professor
Faculty of Medicine School of Medicine Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Cardiovascular and Vital Control Professor
Title
Professor
External link

Degree

  • 医学博士 ( 1994.3   新潟大学 )

Research Interests

  • Transplantation Immunology

  • 移植免疫

  • 胸部外科

  • Thoracic Surgery

Research Areas

  • Life Science / Respiratory surgery

  • Life Science / Cardiovascular surgery

Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Cardiovascular and Vital Control   Professor

    2011.11

  • Niigata University   Faculty of Medicine School of Medicine   Professor

    2011.11

  • Niigata University   University Medical and Dental Hospital   Lecturer

    2003.10 - 2011.11

Professional Memberships

▶ display all

 

Papers

  • The C-reactive protein to albumin ratio is a prognostic factor for stage I non-small cell lung cancer in elderly patients: JACS1303.

    Takuro Miyazaki, Hisashi Saji, Hiroshige Nakamura, Takeshi Nagayasu, Norihito Okumura, Masanori Tsuchida, Makoto Sonobe, Keiju Aokage, Masayuki Nakao, Tomohiro Haruki, Morihito Okada, Kenji Suzuki, Masayuki Chida, Ichiro Yoshino

    Surgery today   2022.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: To establish the prognostic significance of C-reactive protein (CRP) and albumin in octogenarians with non-small cell lung cancer (NSCLC) based on the study of the Japanese Association for Chest Surgery (JACS 1303). METHODS: A total of 618 octogenarians with pathological stage I NSCLC, who underwent pulmonary resection, were included in the analysis. We conducted multivariable Cox regression analysis to evaluate the CRP to albumin ratio (CAR) as a potential prognostic factor. Other clinicopathological factors were also evaluated. RESULTS: The median age was 82 years. Operations included lobectomy (n = 388; 62.8%) segmentectomy (n = 95; 15%), and wedge resection (n = 135; 22%). Pathological stage IA was diagnosed in 380 (61.5%) patients. The 3-year (OS) and cancer-specific survival (CS) rates were 86.7% and 94.6%, respectively. OS was significantly higher for patients with low CAR (< 0.106) than for those with high CAR (≥ 0.106) (hazard ratio = 3.13, 95% confidence interval: 1.99-4.93, p < 0.0001). Univariate analysis identified sex, poor performance status, smoking status, comorbidity, solid tumor, histology, high Glasgow prognostic scale, and high CAR as significant prognostic factors. Multivariate analysis identified only the CAR as a significant prognostic factor for both OS and CS. CONCLUSIONS: Our analysis of the nationwide data demonstrated that the CAR is a useful prognostic factor for elderly patients with stage I NSCLC.

    DOI: 10.1007/s00595-022-02485-9

    PubMed

    researchmap

  • Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice Reviewed

    Masayoshi Suda, Ippei Shimizu, Goro Katsuumi, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Naomi Matsumoto, Yutaka Yoshida, Ryuta Mikawa, Akihiro Katayama, Jun Wada, Masahide Seki, Yutaka Suzuki, Atsushi Iwama, Hironori Nakagami, Ayako Nagasawa, Ryuichi Morishita, Masataka Sugimoto, Shujiro Okuda, Masanori Tsuchida, Kazuyuki Ozaki, Mayumi Nakanishi-Matsui, Tohru Minamino

    Nature Aging   1 ( 12 )   1117 - 1126   2021.12

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s43587-021-00151-2

    researchmap

    Other Link: https://www.nature.com/articles/s43587-021-00151-2

  • 左上葉転位気管支領域に発生した左上葉肺癌に対して胸腔鏡下左S1+2区域切除を施行した1例

    小林 遼平, 土田 正則, 小池 輝元, 後藤 達哉, 清水 勇希, 中村 将弥, 田中 博, 瀬崎 遼

    日本胸部外科学会関東甲信越地方会要旨集   ( 187回 )   27 - 27   2021.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 化学放射線療法後にサルベージ手術を施行したN3肺尖部胸壁浸潤癌の1例

    清水 勇希, 中村 将弥, 後藤 達哉, 小池 輝元, 土田 正則

    肺癌   61 ( 6 )   714 - 714   2021.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • IIIB期肺腺癌の化学放射線療法後の局所再発に対しサルベージ手術を施行した1症例

    中村 将弥, 田中 博, 瀬崎 遼, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    肺癌   61 ( 6 )   713 - 713   2021.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • Prognostic Impact of Mediastinal Lymph Node Dissection in Octogenarians With Lung Cancer: JACS1303. International journal

    Masayuki Nakao, Hisashi Saji, Mingoyn Mun, Hiroshige Nakamura, Norihito Okumura, Masanori Tsuchida, Makoto Sonobe, Takuro Miyazaki, Keiju Aokage, Tomohiro Haruki, Morihito Okada, Kenji Suzuki, Masayuki Chida

    Clinical lung cancer   2021.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: The prognostic significance of mediastinal lymph node dissection (MLND) in elderly patients with non-small cell lung cancer (NSCLC) remains unclear. This post hoc analysis of a nationwide multicenter cohort study (JACS1303) evaluated the prognostic significance of MLND in octogenarians with NSCLC. MATERIALS AND METHODS: We included 622 octogenarians with NSCLC who underwent lobectomy. The median follow-up duration was 41.1 months. We compared survival and perioperative outcomes between patients who did and did not undergo MLND. RESULTS: In total, 414 (67%) patients underwent MLND (ND2 group), whereas 208 (33%) did not undergo MLND (ND0-1 group). The disease stage was more advanced in the ND2 group than in the ND0-1 group. Disease-free survival was slightly greater in the ND0-1 group with marginal significance (P= .079). In the matched cohort (N = 228), which mainly consisted of patients with clinical stage I disease (96%), there was no significant difference between the 2 groups regarding overall and disease-free survival (P= .908 and P = .916, respectively). Operative time and blood loss were significantly lower in the ND0-1 group than in the ND2 group in the entire cohort (P< .001 and P = .050, respectively) and in the matched cohort (P = .003 and P= .046, respectively). CONCLUSION: Based on a nationwide prospective database, we found limited prognostic impact of MLND, suggesting that MLND can be omitted for octogenarians with early-stage NSCLC.

    DOI: 10.1016/j.cllc.2021.09.007

    PubMed

    researchmap

  • Maximum Standardized Uptake Value on Positron Emission Tomography is Associated With More Advanced Disease and High-risk Features in Lung Adenocarcinoma. International journal

    Terumoto Koike, Noriaki Sato, Yuta Hosoda, Masayuki Tazawa, Tatsuya Goto, Seijiro Sato, Motohiko Yamazaki, Shin-Ichi Toyabe, Masanori Tsuchida

    Seminars in thoracic and cardiovascular surgery   2021.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has been widely used for preoperative staging of lung adenocarcinomas. The aim of this study was to determine whether a high maximum standardized uptake value (SUVmax) could correlate with pathological characteristics in those patients. We retrospectively reviewed patients with clinical stage 0-IA lung adenocarcinoma who underwent preoperative 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography followed by curative anatomical resection. To identify more advanced disease and high-risk features, representing visceral pleural involvement, pulmonary metastasis, lymph node involvement, and lymphovascular involvement in resected surgical specimens, univariate and multivariate logistic regression analyses were performed. The optimal cutoff point for the SUVmax was determined by receiver operating characteristic analysis. In 2 groups divided according to the cutoff point, the disease-free survivals were calculated and compared using the Kaplan-Meier method and the log-rank test. More advanced disease and high-risk features were identified in 55 (18.9%) of the 291 patients. SUVmax was significantly correlated with more advanced disease and high-risk features, as did the consolidation/tumor ratio on computed tomography. Only 2 (1.2%) of the 169 patients with a SUVmax <3.20 showed more advanced disease and high-risk features, compared with 43.4% of patients with a SUVmax ≥3.20. The disease-free survival was significantly higher in patients with a SUVmax <3.20 than in those with a SUVmax ≥3.20 (P = 0.002). A high SUVmax correlates with more advanced disease and high-risk features in patients with clinical stage 0-IA lung adenocarcinoma. The SUVmax should be considered when deciding treatment strategy in early-stage lung adenocarcinoma.

    DOI: 10.1053/j.semtcvs.2021.07.019

    PubMed

    researchmap

  • 右上葉切除後の右下葉肺腺癌に対し右S8+9区域切除を施行した一例

    中村 将弥, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 186回 )   38 - 38   2021.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • Surgical outcomes of ipsilateral metachronous second primary lung cancer

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Takahisa Koizumi, Takehiro Watanabe, Hirohiko Shinohara, Yasushi Yamato, Masanori Tsuchida

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   32 ( 6 )   896 - 903   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS  

    OBJECTIVES: The optimal surgical approach for metachronous second primary lung cancer (MSPLC), especially ipsilateral MSPLC, remains unclear. This study aimed to review postoperative complications and examine surgical outcomes based on the extent of resection after surgery for ipsilateral MSPLC.METHODS: Clinical data from 61 consecutive patients who underwent pulmonary resection for ipsilateral MSPLC according to the Martini-Melamed criteria between January 2005 and December 2017 in 3 institutes were retrospectively reviewed.RESULTS: Postoperative complications were identified in 12 patients (19.7%). Regarding the combination of initial and second surgery, intraoperative bleeding was significantly greater in patients with anatomic-anatomic resection than in others (P < 0.001). Operation time was significantly longer in patients with anatomic-anatomic resection than in others (P <0.001). However, postoperative complications showed no significant differences based on the combination of surgeries. Five-year overall survival rates in patients with anatomic resection and wedge resection after second surgery were 75.8% and 75.8%, respectively (P= 0.738), and 5-year recurrence-free survival rates were 54.2% and 67.6%, respectively (P = 0.368). Cox multivariate analysis identified ever-smoker status (P = 0.029), poor performance status (P = 0.011) and tumour size >20 mm (P = 0.001) as independent predictors of poor overall survival, while ever-smoker status (P = 0.040) and tumour size >20 mm (P = 0.007) were considered independent predictors of poor recurrence-free survival.CONCLUSIONS: Regarding postoperative and long-term outcomes for patients with ipsilateral MSPLC, surgical intervention is safe and offers good long-term survival. Wedge resection is an acceptable provided tumours <= 2 cm and ground-glass opacity-predominant as a second surgery for early-stage ipsilateral MSPLC.

    DOI: 10.1093/icvts/ivab025

    Web of Science

    researchmap

  • Surgical outcomes of ipsilateral metachronous second primary lung cancer. International journal

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Takahisa Koizumi, Takehiro Watanabe, Hirohiko Shinohara, Yasushi Yamato, Masanori Tsuchida

    Interactive cardiovascular and thoracic surgery   32 ( 6 )   896 - 903   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: The optimal surgical approach for metachronous second primary lung cancer (MSPLC), especially ipsilateral MSPLC, remains unclear. This study aimed to review postoperative complications and examine surgical outcomes based on the extent of resection after surgery for ipsilateral MSPLC. METHODS: Clinical data from 61 consecutive patients who underwent pulmonary resection for ipsilateral MSPLC according to the Martini-Melamed criteria between January 2005 and December 2017 in 3 institutes were retrospectively reviewed. RESULTS: Postoperative complications were identified in 12 patients (19.7%). Regarding the combination of initial and second surgery, intraoperative bleeding was significantly greater in patients with anatomic-anatomic resection than in others (P < 0.001). Operation time was significantly longer in patients with anatomic-anatomic resection than in others (P < 0.001). However, postoperative complications showed no significant differences based on the combination of surgeries. Five-year overall survival rates in patients with anatomic resection and wedge resection after second surgery were 75.8% and 75.8%, respectively (P = 0.738), and 5-year recurrence-free survival rates were 54.2% and 67.6%, respectively (P = 0.368). Cox multivariate analysis identified ever-smoker status (P = 0.029), poor performance status (P = 0.011) and tumour size >20 mm (P = 0.001) as independent predictors of poor overall survival, while ever-smoker status (P = 0.040) and tumour size >20 mm (P = 0.007) were considered independent predictors of poor recurrence-free survival. CONCLUSIONS: Regarding postoperative and long-term outcomes for patients with ipsilateral MSPLC, surgical intervention is safe and offers good long-term survival. Wedge resection is an acceptable provided tumours ≤2 cm and ground-glass opacity-predominant as a second surgery for early-stage ipsilateral MSPLC.

    DOI: 10.1093/icvts/ivab025

    PubMed

    researchmap

  • 原発性肺腺癌におけるFDG-PET/CTでのDeauville分類の有用性の検討

    田澤 勝幸, 細田 裕太, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   35 ( 3 )   MO1 - 2   2021.5

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 間質性肺炎合併肺癌における非癌部間質性肺炎領域が周術期に与える影響

    佐藤 征二郎, 田澤 勝幸, 細田 裕太, 後藤 達哉, 小池 輝元, 篠原 博彦, 土田 正則

    日本呼吸器外科学会雑誌   35 ( 3 )   O5 - 4   2021.5

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 80歳以上高齢者肺癌に対する縦隔リンパ節郭清省略の意義 JACS1303副次解析

    中尾 将之, 佐治 久, 文 敏景, 中村 廣繁, 奥村 典仁, 土田 正則, 園部 誠, 宮崎 拓郎, 青景 圭樹, 春木 朋広, 鈴木 健司, 千田 雅之

    日本呼吸器外科学会雑誌   35 ( 3 )   RO19 - 5   2021.5

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • Survival of Octogenarians with Early-Stage Non-small Cell Lung Cancer is Comparable Between Wedge Resection and Lobectomy/Segmentectomy: JACS1303. International journal

    Takahiro Mimae, Hisashi Saji, Hiroshige Nakamura, Norihito Okumura, Masanori Tsuchida, Makoto Sonobe, Takuro Miyazaki, Keiju Aokage, Masayuki Nakao, Tomohiro Haruki, Morihito Okada, Kenji Suzuki, Masayuki Chida

    Annals of surgical oncology   2021.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Anatomic resection with lymph node dissection or sampling is the standard treatment for early non-small cell lung cancer (NSCLC), and wedge resection is an option for compromised patients. This study aimed to determine whether wedge resection can provide comparable prognoses for elderly patients with NSCLC. METHODS: The study analyzed the clinicopathologic findings and surgical outcomes during a median follow-up period of 39.6 months for 156 patients with solid dominant (consolidation-to-tumor ratio > 0.5) small (whole tumor size ≤ 2 cm) NSCLC among 892 patients 80 years of age or older with medically operable lung cancer between April 2015 and December 2016. RESULTS: The 3-year overall survival (OS) rates after wedge resection and after segmentectomy plus lobectomy did not differ significantly (86.5 %; 95 % confidence interval [CI], 74.6-93.0 % vs 83.7 % 95 % CI, 74.0-90.0 %; P = 0.92). Multivariable Cox regression analysis of OS with propensity scores showed that the surgical procedure was not an independent prognostic predictor (hazard ratio [HR], 0.84; 95 % CI, 0.39-1.8; P = 0.64). The 3-year OS rates were slightly better after wedge resection for 97 patients who could tolerate lobectomy than after segmentectomy plus lobectomy (89.4 %; 95 % CI, 73.8-95.9 % vs 75.8 %; 95 % CI, 62.0-85.2 %; P = 0.14). The cumulative incidence of other causes for death was marginally higher after segmentectomy plus lobectomy than after wedge resection (P = 0.079). CONCLUSIONS: Wedge resection might be equivalent to lobectomy or segmentectomy for selected patients 80 years of age or older with early-stage NSCLC who can tolerate lobectomy.

    DOI: 10.1245/s10434-021-09835-w

    PubMed

    researchmap

  • 右肺下葉切除術後左主気管支食道瘻に対して上部消化管内視鏡的クリッピングで治癒し得た一例

    細田 裕太, 田澤 勝幸, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 185回 )   20 - 20   2021.3

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • Mutational signatures in squamous cell carcinoma of the lung. International journal

    Atsushi Osoegawa, Kazuki Takada, Tatsuro Okamoto, Seijiro Sato, Masayuki Nagahashi, Tetsuzo Tagawa, Masanori Tsuchida, Eiji Oki, Shujiro Okuda, Toshifumi Wakai, Masaki Mori

    Journal of thoracic disease   13 ( 2 )   1075 - 1082   2021.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Background: Tumor mutational burden (TMB) has been identified as one of the predictors for the response to anti-programmed cell death-1 (anti-PD-1) antibody therapy and reported to correlate with smoking history in lung adenocarcinoma. However, in squamous cell carcinoma of the lung, the association between TMB and clinicopathological background factors, such as smoking history, has not been reported, including in our previous study. The mutational signature is a tool to identify the mutagens that are contributing to the mutational spectrum of a tumor by investigating the pattern of DNA changes. Here, we analyzed the mutational signature in lung squamous cell carcinoma to identify mutagens affecting the TMB. Methods: Seven representative mutational signatures including signature 7 (SI7) [ultraviolet (UV)-related], SI4 (smoking), SI6/15 [mismatch repair (MMR)], SI2/13 [apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC)], and SI5 (clock-like) were analyzed in Japanese patients with lung squamous cell carcinoma (n=67) using data generated by next-generation sequencing consisting of a 415-gene panel. The relationships between signatures and clinico-pathological data including TMB and programmed death-ligand 1 (PD-L1) expression were analyzed. Results: Although the reconstructed mutational counts were small with targeted sequencing (median: 30.1, range: 13.3-98.7), the distributions of signatures were comparable among samples, with 56 cases containing more than four signatures. The smoking-related SI4 was found in 45 cases and was significantly related with pack-year index (PYI) (P=0.026). The reconstructed mutation counts were highly correlated with SI4 (r=0.51, P<0.0001), whereas the correlation was weak with SI6/15 (MMR-related) and SI2/13 (APOBEC-related). There was no mutational signature related with PD-L1 expression. Some patients exhibited unique signatures; the patient with the highest mutational counts had a MMR signature, and another patient with a prominent UV signature had occupational exposure to UV, as he was employed as a neon sign engineer. Conclusions: Mutational signatures can predict the cause of lung squamous cell carcinoma. Tobacco smoking is the mutagen most related with TMB.

    DOI: 10.21037/jtd-20-2602

    PubMed

    researchmap

  • Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients

    Riuko Ohashi, Hajime Umezu, Ayako Sato, Tatsuya Abé, Shuhei Kondo, Kenji Daigo, Seijiro Sato, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Teiichi Motoyama, Masashi Kishi, Tadahiro Nagaoka, Keiko Horiuchi, Atsushi Shiga, Shujiro Okuda, Tomoki Sekiya, Aya Ohtsubo, Kosuke Ichikawa, Hiroshi Kagamu, Toshiaki Kikuchi, Satoshi Watanabe, Jun-Ichi Tanuma, Peter Schraml, Takao Hamakubo, Masanori Tsuchida, Yoichi Ajioka

    Cells   9 ( 11 )   2409 - 2409   2020.11

     More details

    Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Ribosomal RNA (rRNA), the most abundant non-coding RNA species, is a major component of the ribosome. Impaired ribosome biogenesis causes the dysfunction of protein synthesis and diseases called “ribosomopathies,” including genetic disorders with cancer risk. However, the potential role of rRNA gene (rDNA) alterations in cancer is unknown. We investigated germline and somatic single-nucleotide variants (SNVs) in the rDNA promoter region (positions −248 to +100, relative to the transcription start site) in 82 lung adenocarcinomas (LUAC). Twenty-nine tumors (35.4%) carried germline SNVs, and eight tumors (9.8%) harbored somatic SNVs. Interestingly, the presence of germline SNVs between positions +1 and +100 (n = 12; 14.6%) was associated with significantly shorter recurrence-free survival (RFS) and overall survival (OS) by univariate analysis (p &lt; 0.05, respectively), and was an independent prognostic factor for RFS and OS by multivariate analysis. LUAC cell line PC9, carrying rDNA promoter SNV at position +49, showed significantly higher ribosome biogenesis than H1650 cells without SNV. Upon nucleolar stress induced by actinomycin D, PC9 retained significantly higher ribosome biogenesis than H1650. These results highlight the possible functional role of SNVs at specific sites of the rDNA promoter region in ribosome biogenesis, the progression of LUAC, and their potential prognostic value.

    DOI: 10.3390/cells9112409

    researchmap

  • 気管原発腺様嚢胞癌に対しV-V ECMO下で気管切除・再建を施行した一例

    細田 裕太, 後藤 達哉, 田澤 勝幸, 佐藤 哲彰, 大久保 由華, 佐藤 征二郎, 三島 健人, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 184回 )   18 - 18   2020.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • Salvage surgery to treat tumor regrowth after stereotactic body radiotherapy in primary non-small cell lung cancer. International journal

    Takahisa Koizumi, Tadashi Aoki, Masayuki Saito, Yasushi Yamato, Go Furuyashiki, Akihiko Kitahara, Takehisa Hashimoto, Takehiro Watanabe, Masanori Tsuchida

    Journal of thoracic disease   12 ( 10 )   5289 - 5298   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Background: Stereotactic body radiotherapy (SBRT) is considered to be an effective and safe treatment in patients with primary lung cancer. If local recurrence is confirmed following SBRT, surgical treatment is a possibility. The present study aimed to clarify the safety and survival outcomes of salvage surgery in primary lung cancer patients with local recurrence following SBRT. Methods: All subjects were patients with primary lung cancer who underwent surgical treatment for local recurrence following SBRT during the period from July 2005 to July 2015. We evaluated the reason for SBRT selection, the surgical procedure, postoperative complications, and prognosis. Results: Of 932 patients underwent SBRT as treatment for primary lung cancer, 48 patients (5.2%) had local recurrence alone and 19 patients (2.0%) underwent salvage surgery. SBRT was selected in eight medically operable patients who refused surgery, and in 11 patients considered medically inoperable by their pulmonologist. Lobectomy was performed in 15 patients. Postoperative complications were documented in 4 patients (21.1%). Incomplete resection was performed in 2 patients. Stage progression was confirmed in 7 patients (36.8%). The 5-year overall survival (OS) was 72.5% and the 5-year disease-free survival (DFS) was 65.2%. Conclusions: We evaluated patients who underwent salvage surgery due to local recurrence of lung cancer following SBRT. We found that salvage surgery could be performed safely without affecting SBRT outcomes. We further infer that cases of complete resection are likely to be associated with good prognosis, and that SBRT should be selected only after careful consideration because complete resection is not possible in all cases.

    DOI: 10.21037/jtd-20-2253

    PubMed

    researchmap

  • 肺癌切除に起因する術後早期胸腔内合併症に対する緊急残存肺全摘の経験

    土田 正則, 田澤 勝幸, 細田 裕太, 後藤 達哉, 佐藤 征二郎, 小池 輝元

    日本胸部外科学会定期学術集会   73回   LOO14 - 35   2020.10

     More details

    Language:Japanese   Publisher:(一社)日本胸部外科学会  

    researchmap

  • 非小細胞肺癌根治切除症例において術後末梢血好中球/リンパ球比の意義の検討

    田澤 勝幸, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会定期学術集会   73回   LOO15 - 10   2020.10

     More details

    Language:Japanese   Publisher:(一社)日本胸部外科学会  

    researchmap

  • Radical segmentectomy as a potential alternative surgical treatment with curative intent in early-stage non-small cell lung cancer. International journal

    Terumoto Koike, Tatsuya Goto, Seijiro Sato, Masanori Tsuchida

    Journal of thoracic disease   12 ( 10 )   6115 - 6119   2020.10

     More details

  • 慢性閉塞性肺疾患合併非小細胞肺癌における気腫病変の意義

    佐藤 征二郎, 田澤 勝幸, 細田 裕太, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    日本胸部外科学会定期学術集会   73回   LOO1 - 24   2020.10

     More details

    Language:Japanese   Publisher:(一社)日本胸部外科学会  

    researchmap

  • Characteristics and risk factors of recurrence in clinical stage I non-small cell lung cancer patients undergoing anatomic segmentectomy.

    Terumoto Koike, Akihiro Nakamura, Yuki Shimizu, Tatsuya Goto, Seijiro Sato, Shin-Ichi Toyabe, Masanori Tsuchida

    General thoracic and cardiovascular surgery   68 ( 9 )   1011 - 1017   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Although lobectomy is the standard surgical procedure for small-sized non-small cell lung cancer (NSCLC), segmentectomy has been performed for various reasons. The aim of this study was to investigate the characteristics of and risk factors for recurrence in early-stage NSCLC patients undergoing segmentectomy. METHODS: We retrospectively reviewed 179 patients with clinical stage I NSCLC who underwent segmentectomy. Preoperative factors were analyzed using the log-rank test for univariate analyses. Multivariate analyses were performed using a Cox proportional hazards regression model to identify independent risk factors for recurrence. For the significant factors, optimal cutoff points were determined by receiver operating characteristic (ROC) analysis. RESULTS: During the follow-up period of 51 months, 18 patients developed recurrence; 5 had locoregional (including 2 with margin recurrences only), 9 had distant, and 4 had both locoregional and distant recurrence. Multivariate and ROC analysis identified radiologic solid tumor size with a cutoff point of 1.5 cm as an independent risk factor for recurrence. Three patients in the solid size < 1.5 cm group (n = 119) developed recurrence, 2 of whom had surgical margin recurrence, compared to 15 patients in the solid size ≥ 1.5 cm group (n = 60). CONCLUSIONS: The indication for segmentectomy should be decided upon with caution, and the segments to be resected should be carefully considered to secure an appropriate surgical margin in this low-risk subgroup of patients because they may have a relatively higher risk of surgical margin recurrence, despite being at decreased risk.

    DOI: 10.1007/s11748-020-01338-x

    PubMed

    researchmap

  • 右房・無名静脈バイパスが開存していたGlenn手術原法・Bjoerk手術後遠隔期の蛋白漏出性胃腸症に対しTCPC転換術を施行した1例

    白石 修一, 杉本 愛, 土田 正則

    日本心臓血管外科学会雑誌   49 ( 5 )   257 - 260   2020.9

     More details

    Language:Japanese   Publisher:(NPO)日本心臓血管外科学会  

    症例は37歳男性。三尖弁閉鎖の診断で左Blalock Taussigシャント手術原法、Glenn手術原法、左肺動脈形成術の既往あり。10歳時にBjoerk手術を施行したが、術後に循環不全となり心肺補助装置を装着された。上下大静脈間の著明な圧較差を認めたため、人工血管による右房・無名静脈バイパス術を追加し心肺補助装置を離脱し得た。術後他院にて経過観察されていたが、30歳頃より心房頻拍が出現、36歳時より蛋白漏出性胃腸症を発症した。内科的治療でも改善を認めないため当院再診した。心臓カテーテル検査にて右房・無名静脈間の人工血管の開存が確認され、左肺動脈が低形成のため下大静脈血流は一部が人工血管経由に無名静脈から右肺動脈へ還流しており、上下大静脈間の圧較差を認めた。手術は人工心肺・心停止下に右房アブレーション、心外導管を用いたTCPC転換術、大動脈前方での左肺動脈再建、右房-心外導管間のfenestration作成および心外膜ペースメーカーリード装着術を行った。術後34日に退院した。蛋白漏出性胃腸症は軽快し3年経過した現在も再発は認めていない。(著者抄録)

    researchmap

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01122&link_issn=&doc_id=20200928350003&doc_link_id=10.4326%2Fjjcvs.49.257&url=https%3A%2F%2Fdoi.org%2F10.4326%2Fjjcvs.49.257&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 血管平滑筋p53の大動脈解離発症機構への関与

    長澤 綾子, 清水 逸平, 吉田 陽子, 土田 正則, 南野 徹

    日本外科学会定期学術集会抄録集   120回   SF - 7   2020.8

     More details

    Language:Japanese   Publisher:(一社)日本外科学会  

    researchmap

  • TNM分類に基づく胸腺上皮性腫瘍に対する外科治療成績

    清水 勇希, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   34 ( 3 )   MO46 - 1   2020.8

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 上肺静脈心嚢内結紮を行った左肺上葉切除症例の検討

    北原 哲彦, 清水 勇希, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   34 ( 3 )   MO4 - 3   2020.8

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • A Case Report of Reconstruction of the Left Superior Vena Cava Using the Right Superior Vena Cava Autograft at Bilateral Bidirectional Superior Cavopulmonary Anastomosis. International journal

    Shuichi Shiraishi, Ai Sugimoto, Jiyong Moon, Masashi Takahashi, Masanori Tsuchida

    World journal for pediatric & congenital heart surgery   11 ( 4 )   NP63-NP65   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The choice of graft material for reconstruction of the vena cava in pediatric patients remains controversial. We successfully treated an eight-month-old female patient with single ventricle physiology and long segment obstruction of the left superior vena cava using the right superior vena cava autograft at the time of bilateral bidirectional superior cavopulmonary anastomosis. Postoperative computed tomography confirmed the patency of the reconstruction.

    DOI: 10.1177/2150135117706951

    PubMed

    researchmap

  • Impact of postoperative complications on outcomes of second surgery for second primary lung cancer.

    Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Masanori Tsuchida

    Surgery today   50 ( 11 )   1452 - 1460   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: The best surgical approach for second primary lung cancer remains a subject of debate. The purpose of this study was to review the postoperative complications after second surgery for second primary lung cancer and to investigate the outcomes based on these complications. METHODS: The clinical data of 105 consecutive patients who underwent pulmonary resection for multiple primary lung cancers between January, 1996 and December, 2017, were reviewed according to the Martini-Melamed criteria. RESULTS: After the second surgery, low body mass index (BMI) (< 18.5 kg/m2) (P = 0.004) and high Charlson comorbidity index (CCI) (P = 0.002) were independent predictors of postoperative complications. Survival analysis revealed the 5-year overall survival rates of 74.5% and 61.4% for patients without postoperative complications and those with postoperative complications (P = 0.044), respectively, but the 5-year cancer-specific survival rates of 82.5% and 80.0% (P = 0.926), respectively. During this period, there were significantly more respiratory-related deaths of patients with complications than of those without complications (P = 0.011). CONCLUSION: Surgical intervention is feasible and potentially effective for second primary lung cancer but may not achieve positive perioperative and long-term outcomes for patients with a low BMI or a high CCI. Treatment options should be considered carefully for these patients.

    DOI: 10.1007/s00595-020-02038-y

    PubMed

    researchmap

  • Primary lung squamous cell carcinoma and its association with gastric metastasis: A case report and literature review. International journal

    Mariko Nemoto, Pankaj Prasoon, Hiroshi Ichikawa, Takaaki Hanyu, Yosuke Kano, Yusuke Muneoka, Kenji Usui, Yuki Hirose, Kohei Miura, Yoshifumi Shimada, Masayuki Nagahashi, Jun Sakata, Takashi Ishikawa, Masanori Tsuchida, Toshifumi Wakai

    Thoracic cancer   11 ( 6 )   1708 - 1711   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Nearly 50% of primary lung carcinoma patients present with distant metastasis at their first visit. However, gastrointestinal tract (GIT) metastasis is an infrequent impediment. Herein, we report a case of progressive dysphagia and epigastralgia as an initial manifestation of recurrence as gastric metastasis of primary lung squamous cell carcinoma (SCC) after curative surgery. A 64-year-old man was diagnosed with primary lung SCC of the right lower lobe, and underwent thoracoscopic lower lobectomy. One year after lobectomy, computed tomography (CT) scan showed a gastric fundal mass located in the gastric cardia which measured 5 cm. Endoscopic biopsies and histopathology subsequently confirmed that tumor was SCC. The patient then underwent proximal gastrectomy with resection of the diaphragmatic crus. Following surgery, histopathological examination revealed gastric metastasis from primary lung SCC. KEY POINTS: Gastric metastasis of primary lung carcinoma is one of the rarest phenomena. Gastrointestinal symptoms should raise suspicion of the presence of advanced metastatic disease with poor prognosis.

    DOI: 10.1111/1759-7714.13410

    PubMed

    researchmap

  • Adverse impact of univentricular pacing for the patient with functional single ventricle: successful conversion to cardiac resynchronization therapy. International journal

    Ai Sugimoto, Kiyohiro Takigiku, Shuichi Shiraishi, Masashi Takahashi, Masanori Tsuchida

    Surgical case reports   6 ( 1 )   101 - 101   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: In a Fontan candidate, univentricular pacing may cause delay in interventricular conduction, which induces asynchronous contraction. Cardiac resynchronization therapy is expected to be an effective mode of therapy in such a case. CASE PRESENTATION: A 7-month-old girl, diagnosed with dextrocardia, congenitally corrected transposition of the great artery [situs solitus, L-loop, and L-transposition], ventricular septal defect, infundibular and pulmonary valvular stenosis, and straddling of the tricuspid valve, was considered as a candidate for the Fontan procedure. She had undergone Blalock-Taussig shunt, and epicardial univentricular pacemaker implantation for persistent complete atrioventricular block. She underwent a bidirectional cavopulmonary shunt concomitant with ventricular lead translocation from the morphological left ventricle to the morphological right ventricle. After discharge, ventricular dyssynchrony was noted and cardiac failure persisted. She was converted to cardiac resynchronization therapy (CRT) at 13 months of age. Two-dimensional speckle tracking imaging was used by cardiologists to determine the most suitable pacing site. CRT rapidly corrected the heart failure; thus, she underwent the Fontan procedure after 1.5 years. Five years have passed since the cardiac resynchronization therapy; her interventricular synchrony is maintained well and the level of brain natriuretic peptide remains within normal range. CONCLUSION: We describe the successful conversion from single ventricular pacing to CRT, in a case of congenitally corrected transposition of the great artery indicated for the Fontan procedure. The long-term prognosis of cardiac resynchronization therapy is undetermined in the pediatric population; therefore, further follow-up is required.

    DOI: 10.1186/s40792-020-00863-4

    PubMed

    researchmap

  • Generation of Lungs by Blastocyst Complementation in Apneumic Fgf10-Deficient Mice. Reviewed International journal

    Akihiko Kitahara, Qingsong Ran, Kanako Oda, Akihiro Yasue, Manabu Abe, Xulu Ye, Toshikuni Sasaoka, Masanori Tsuchida, Kenji Sakimura, Yoichi Ajioka, Yasuo Saijo, Qiliang Zhou

    Cell reports   31 ( 6 )   107626 - 107626   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The shortage of donor lungs hinders lung transplantation, the only definitive option for patients with end-stage lung disease. Blastocyst complementation enables the generation of transplantable organs from pluripotent stem cells (PSCs) in animal models. Pancreases and kidneys have been generated from PSCs by blastocyst complementation in rodent models. Here, we report the generation of lungs using mouse embryonic stem cells (ESCs) in apneumic Fgf10 Ex1mut/Ex3mutmice by blastocyst complementation. Complementation with ESCs enables Fgf10-deficient mice to survive to adulthood without abnormalities. Both the generated lung alveolar parenchyma and the interstitial portions, including vascular endothelial cells, vascular and parabronchial smooth muscle cells, and connective tissue, largely originate from the injected ESCs. These data suggest that Fgf10 Ex1mut/Ex3mutblastocysts provide an organ niche for lung generation and that blastocyst complementation could be a viable approach for generating whole lungs.

    DOI: 10.1016/j.celrep.2020.107626

    PubMed

    researchmap

  • A novel suture technique in closing the single drainage tube hole in uni-portal video-assisted thoracoscopic surgery. International journal

    Terumoto Koike, Seijiro Sato, Masanori Tsuchida

    Annals of translational medicine   8 ( 7 )   424 - 424   2020.4

     More details

  • 【循環器症候群(第3版)-その他の循環器疾患を含めて-】先天性心・大血管疾患 大動脈左室トンネル

    白石 修一, 杉本 愛, 土田 正則

    日本臨床   別冊 ( 循環器症候群IV )   367 - 369   2020.3

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

    researchmap

  • 【循環器症候群(第3版)-その他の循環器疾患を含めて-】先天性心・大血管疾患 部分肺静脈還流異常症

    白石 修一, 杉本 愛, 土田 正則

    日本臨床   別冊 ( 循環器症候群IV )   303 - 305   2020.3

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

    researchmap

  • Swing-back and trap-door technique repair for interrupted aortic arch with right-sided descending aorta. International journal

    Shuichi Shiraishi, Ai Sugimoto, Masanori Tsuchida

    Interactive cardiovascular and thoracic surgery   29 ( 5 )   818 - 819   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    A right-sided descending aorta with a left aortic arch is a rare congenital anomaly in which the aortic arch crosses the midline from the left side of the trachea coursing to the descending aorta in the right thoracic cavity. The surgical repair of an interrupted aortic arch with a right-sided descending aorta carries great risks of bronchial and oesophageal obstruction. Herein, we describe a case of successful surgical repair of an interrupted aortic arch with a right-sided descending aorta using the swing-back and trap-door techniques.

    DOI: 10.1093/icvts/ivz175

    PubMed

    researchmap

  • 胸腔鏡下ICG蛍光ナビゲーション手術が有用であった不全分葉を有する小児肺葉内肺分画症の1例

    平山 裕, 小池 輝元, 飯沼 泰史, 土田 正則

    小児外科   51 ( 10 )   1047 - 1051   2019.10

     More details

    Language:Japanese   Publisher:(株)東京医学社  

    12歳女児。腹痛にて近医を受診した際、X線検査にて右下肺野の嚢胞陰影が指摘された。その後は前医へ紹介され、CT検査にて不全分葉を有する肺葉内肺分画症と診断され、手術目的で当科へ紹介となった。当科では腹腔鏡下ICG蛍光ナビゲーション手術を計画し、適切な葉間切離線を設定することで肺切除を行うことが可能であった。術後は経過良好で、術後第4病日に退院となった。

    researchmap

  • Superior Vena Cava Flap to Reroute Partial Anomalous Pulmonary Venous Connection. International journal

    Ai Sugimoto, Shuichi Shiraishi, Masashi Takahashi, Masanori Tsuchida

    World journal for pediatric & congenital heart surgery   10 ( 5 )   645 - 647   2019.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    A 46-year-old man who had undergone atrial septal defect closure during childhood was referred for surgery for residual partial anomalous pulmonary venous connection. The anomalous pulmonary veins were connected to the higher (cephalad) segment of the superior vena cava. As the usual caval division technique was not applicable, we chose to utilize the anterior wall of the superior vena cava as a flap for anomalous pulmonary vein rerouting. Bovine pericardium was used to reconstruct the systemic venous pathway. Systemic or pulmonary venous stenosis was not detected. The patient was discharged with a sinus rhythm.

    DOI: 10.1177/2150135119862596

    PubMed

    researchmap

  • 新潟県中越沖地震被災地域一般住民における貼り付け型プローブを用いた総頸動脈のhigh intensity transient signalsと脳・心血管疾患との関連

    榛沢 和彦, 伊倉 真衣子, 岡本 竹司, 大久保 由華, 土田 正則, 中島 孝, 品田 恭子, 岡村 治

    Neurosonology   32 ( 2 )   46 - 52   2019.8

     More details

    Language:Japanese   Publisher:(一社)日本脳神経超音波学会  

    深部静脈血栓症(DVT)フォローアップ検診において、頸部貼り付け型プローブを用いた総頸動脈で検出されるhigh intensity transient signal(HITS)の検査をDVT保有者などに行い、DVTや脳・心血管疾患(CCVDs)などとの関連について検討した。新潟県中越沖地震DVTフォローアップ検診を受診した一般住民のうち522人(男性101人、女性421人)を対象とした。頸動脈HITSが39人(7.5%)で検出され、39人中12人(30.8%)にCCVDsが見つかった。頸動脈HITS検出において統計的に有意な危険因子はvelocity pulse index(AVI)、CCVDsの既往、心房細動(AF)/発作性心房細動(PAF)であった。一方、CCVDsの有無による背景因子では、年齢、HITS、糖尿病で有意差を認めた。頸動脈HITSが検出された場合にCCVDsに対する感度は19%、特異度は94%、陽性的中率31%、陰性的中率89%、AF/PAFに対する感度は24%、特異度は94%、陽性的中率は21%、陰性的中率は95%であった。

    researchmap

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J02558&link_issn=&doc_id=20190909400002&doc_link_id=10.2301%2Fneurosonology.32.46&url=https%3A%2F%2Fdoi.org%2F10.2301%2Fneurosonology.32.46&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • [Thoracoscopic Left Upper Division Segmentectomy for Multiple Ground-glass Nodules Using Preoperative Virtual-assisted Lung Mapping].

    Yuki Shimizu, Masaya Nakamura, Tatsuya Goto, Seijiro Sato, Terumoto Koike, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   72 ( 7 )   528 - 533   2019.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Associated with an increase of small-sized lung cancer or metachronous second primary lung cancer, we have more opportunities to perform sublobar resection. Difficulties of identifying tumor location and appropriate surgical margin for small-sized ground-glass opacity (GGO) dominant lesions in thoracoscopic surgery is the big issue of sublobar resection. Virtual-assisted lung mapping (VAL-MAP) that makes markings on the lung surface through some peripheral bronchi by bronchoscopically projects intrapulmonary anatomy on the lung surface and literally draw a map. We report a case of thoracoscopic left upper division segmentectomy for multiple ground-glass nodules (GGNs) using preoperative VAL-MAP. A 65-year-old women who had undergone right upper lobectomy for primary lung cancer, and had multiple GGNs in the bilateral lungs was followed up as an outpatient. Eleven years after initial pulmonary resection, 2 lesions in the left upper division became bigger, and we decided to perform surgery for 4 GGNs in the left upper division including these 2 lesions. We preoperatively made bronchoscopic dye markings through B1+2c, B3a and B4a for in the left upper lobe. The 3 markings were intraoperatively identified. We decided the resection line based on the markings and performed thoracoscopic left upper division segmentectomy. The pathological diagnosis was minimally invasive adenocarcinoma, adenocarcinoma in situ and pneumonitis. Surgical margins were negative. VAL-MAP will assume an important role as an intraoperative navigation system for sublobar resection.

    PubMed

    researchmap

  • 【肺区域・亜区域・複雑区域切除の工夫と実際】VAL-MAP法 Virtual-assisted lung mapping(VAL-MAP)を用いた多発肺野限局性スリガラス結節に対する胸腔鏡下左上区切除

    清水 勇希, 中村 将弥, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    胸部外科   72 ( 7 )   528 - 533   2019.7

     More details

    Language:Japanese   Publisher:(株)南江堂  

    65歳女。胸部CT異常影を主訴とした。右肺上葉切除術後の多発スリガラス結節(GGN)症例であり、胸部CTでは左肺S1+2a末梢に2ヵ所、左肺S3c末梢とS3aにそれぞれGGNを認め、いずれも肺癌の可能性があったため、全ての病変を含むよう区域切除を選択した。また、S3aの病変は術中触知困難が予想され、左肺S4+5との区域間に近接していたため、切離ラインの設定補助目的でvirtual-assisted lung mapping(VAL-MAP)を用い、胸腔鏡下左上区切除を行った結果、病変からのマージンを確保しつつ、残存区域の損失を最小限にするよう胸腔鏡下に完全切除できた。術後5年で再発はなく、残存するGGN病変も著変なく経過している。VAL-MAPは触知困難病変に対する胸腔鏡下区域切除において、特に有用であった。

    researchmap

    Other Link: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00349&link_issn=&doc_id=20190701230011&doc_link_id=1573950786545221248&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1573950786545221248&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  • 増大する両側多発肺結節を伴った縦隔原発Growing teratoma syndromeの1切除例

    中村 将弥, 佐藤 征二郎, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    肺癌   59 ( 3 )   325 - 325   2019.6

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 肺分画症に対する胸腔鏡下左底区切除後の肺静脈還流障害の1例

    清水 勇希, 中村 将弥, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 180回 )   25 - 25   2019.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • A novel parameter for pulmonary blood flow during palliative procedures: velocity time integral of the pulmonary vein†. International journal

    Shuichi Shiraishi, Keiko Bamba, Ai Sugimoto, Masashi Takahashi, Masanori Tsuchida

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery   55 ( 5 )   823 - 828   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: The main goal of palliative procedures for congenital heart defects is adequate pulmonary blood flow (PBF), but precise intraoperative PBF evaluation is sometimes difficult. The purpose of this preliminary study was to investigate the usefulness of velocity time integral of the pulmonary vein (PV-VTI) measured by transoesophageal echocardiography (TOE) at the time of palliative procedure as a parameter for PBF. METHODS: Case histories of 63 patients who underwent palliative procedures (bilateral pulmonary artery banding in 18 patients, main pulmonary artery banding in 22 patients and systemic-to-pulmonary artery shunt in 23 patients) and whose intraoperative PV-VTI was measured by TOE from 2011 to 2017 at our centre were retrospectively reviewed. Low-body-weight infants, cases in which cardiopulmonary bypass was used and cases that were anatomically difficult to measure were excluded. RESULTS: PV-VTIs measured at 4 orifices of the pulmonary veins were all significantly decreased in both the bilateral pulmonary artery banding and main pulmonary artery banding groups and increased in the systemic-to-pulmonary artery shunt group immediately after the procedure. There were significant correlations between the velocity time integrals of both right and left pulmonary veins and arterial oxygen saturation (r = 0.564 and 0.703). Nine patients (6 bilateral pulmonary artery banding and 3 systemic-to-pulmonary artery shunt) required unplanned early reoperation due to inadequate PBF; their PV-VTIs were significantly different from those of patients not requiring reoperation. No major complications related to TOE occurred postoperatively. CONCLUSIONS: The PV-VTI measured by TOE during palliative procedures reflected the change of PBF and could help identify patients at higher risk of early reoperation due to inadequate PBF. This parameter may be a useful additional tool for evaluating intraoperative PBF.

    DOI: 10.1093/ejcts/ezy465

    PubMed

    researchmap

  • The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study. International journal

    Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa, Masanori Tsuchida

    BMC pulmonary medicine   19 ( 1 )   73 - 73   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known. The objective of this study was to investigate the association between the extent of emphysema and long-term outcomes, as well as mortality and postoperative complications, in early-stage lung cancer patients after pulmonary resection. METHODS: The clinical records of 566 consecutive lung cancer patients who underwent pulmonary resection in our department were retrospectively reviewed. Among these, the data sets of 364 pathological stage I patients were available. The associations between the extent of lung emphysema and long-term outcomes and postoperative complications were investigated. Emphysema was assessed on the basis of semiquantitative CT. Surgery-related complications of Grade ≥ II according to the Clavien-Dindo classification were included in this study. RESULTS: Emphysema was present in 63 patients. The overall survival and relapse-free survival of the non-emphysema and emphysema groups at 5 years were 89.0 and 61.3% (P < 0.001), respectively, and 81.0 and 51.7%, respectively (P < 0.001). On multivariate analysis, significant prognostic factors were emphysema, higher smoking index, and higher histologic grade (p < 0.05). Significant risk factors for poor recurrence-free survival were emphysema, higher smoking index, higher histologic grade, and presence of pleural invasion (P < 0.05). Regarding Grade ≥ II postoperative complications, pneumonia and supraventricular tachycardia were more frequent in the emphysema group than in the non-emphysema group (P = 0.003 and P = 0.021, respectively). CONCLUSION: The presence of emphysema affects the long-term outcomes and the development of postoperative complications in early-stage lung cancer patients.

    DOI: 10.1186/s12890-019-0839-1

    PubMed

    researchmap

  • p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. Reviewed International journal

    Masataka Yokoyama, Ippei Shimizu, Ayako Nagasawa, Yohko Yoshida, Goro Katsuumi, Takayuki Wakasugi, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Yusuke Ota, Sho Okada, Marcus Fruttiger, Yoshio Kobayashi, Masanori Tsuchida, Yoshiaki Kubota, Tohru Minamino

    Journal of molecular and cellular cardiology   129   105 - 117   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    p53 is a guardian of the genome that protects against carcinogenesis. There is accumulating evidence that p53 is activated with aging. Such activation has been reported to contribute to various age-associated pathologies, but its role in vascular dysfunction is largely unknown. The aim of this study was to investigate whether activation of endothelial p53 has a pathological effect in relation to endothelial function. We established endothelial p53 loss-of-function and gain-of-function models by breeding endothelial-cell specific Cre mice with floxed Trp53 or floxed Mdm2/Mdm4 mice, respectively. Then we induced diabetes by injection of streptozotocin. In the diabetic state, endothelial p53 expression was markedly up-regulated and endothelium-dependent vasodilatation was significantly impaired. Impairment of vasodilatation was significantly ameliorated in endothelial p53 knockout (EC-p53 KO) mice, and deletion of endothelial p53 also significantly enhanced the induction of angiogenesis by ischemia. Conversely, activation of endothelial p53 by deleting Mdm2/Mdm4 reduced both endothelium-dependent vasodilatation and ischemia-induced angiogenesis. Introduction of p53 into human endothelial cells up-regulated the expression of phosphatase and tensin homolog (PTEN), thereby reducing phospho-eNOS levels. Consistent with these results, the beneficial impact of endothelial p53 deletion on endothelial function was attenuated in EC-p53 KO mice with an eNOS-deficient background. These results show that endothelial p53 negatively regulates endothelium-dependent vasodilatation and ischemia-induced angiogenesis, suggesting that inhibition of endothelial p53 could be a novel therapeutic target in patients with metabolic disorders.

    DOI: 10.1016/j.yjmcc.2019.02.010

    PubMed

    researchmap

  • 臨床病期IA期非小細胞肺癌患者におけるFDG-PET/CTによる病理学的浸潤・転移の予測

    小池 輝元, 中村 将弥, 清水 勇希, 後藤 達哉, 佐藤 征二郎, 土田 正則

    日本呼吸器外科学会雑誌   33 ( 3 )   P16 - 1   2019.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 術後合併症リスクから考える第二原発肺癌に対する治療戦略

    佐藤 征二郎, 中村 将弥, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   33 ( 3 )   P58 - 1   2019.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 進行肺癌に対する分子標的治療薬使用後サルベージ手術を施行した2例

    中村 将弥, 佐藤 征二郎, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   33 ( 3 )   P70 - 5   2019.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 肺癌同側解剖学的手術例における周術期成績

    清水 勇希, 佐藤 征二郎, 中村 将弥, 後藤 達哉, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   33 ( 3 )   O15 - 1   2019.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 術前導入化学放射線療法後に気管支肺動脈一括処理および左房合併切除を施行した原発性肺癌の1例

    清水 勇希, 中村 将弥, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 179回 )   17 - 17   2019.3

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • Early and mid-term outcomes of simultaneous thoracic endovascular stent grafting and combined resection of thoracic malignancies and the aortic wall.

    Seijiro Sato, Atsuhiro Nakamura, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Takeshi Okamoto, Masanori Tsuchida

    General thoracic and cardiovascular surgery   67 ( 2 )   227 - 233   2019.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: To aim of this study was to clarify the safety of simultaneous thoracic aortic endografting and combined resection of the aortic wall and thoracic malignancy in a one-stage procedure over the early and mid-term periods. METHODS: From March 2013 to December 2017, 6 patients underwent aortic endografting followed by one-stage en bloc resection of the tumor and aortic wall. Thoracic surgeons and cardiovascular surgeons discussed predicted tumor invasion range and resection site, stent placement position, stent length and size, and the surgical procedure, taking into account the safe margin. RESULTS: The proximal site of aortic endografting was the: aortic arch in 2 cases (subclavian artery (SCA) occlusion in one, and SCA fenestration in one); distal arch just beneath the SCA in 2; descending aorta in 2. Pulmonary resection involved lobectomy in 2 patients, pneumonectomy in 2, and completion pneumonectomy in 1. Aortic resection was limited to the adventitia in 2 cases, extended to the media in 3, and extended to the intima in 1. An endograft-related complication, external iliac artery intimal damage requiring vessel repair, was observed in one case. No complications associated with aortic resection were observed. Two postoperative complications of atrial fibrillation and chylothorax developed. There were no surgery-related deaths. During follow-up, no late endograft-related complications such as migration or endoleaks occurred. CONCLUSIONS: Early and mid-term outcomes of stent graft-related complications are acceptable. Simultaneous thoracic aortic endografting and combined resection of the aortic wall and thoracic malignancies are feasible in one stage on the same day.

    DOI: 10.1007/s11748-018-1003-1

    PubMed

    researchmap

  • Left colic artery aneurysm rupture after stent placement for abdominal aortic aneurysm associated with neurofibromatosis type 1. International journal

    Kazuki Moro, Hitoshi Kameyama, Kaoru Abe, Junko Tsuchida, Yosuke Tajima, Hiroshi Ichikawa, Masato Nakano, Mayuko Ikarashi, Masayuki Nagahashi, Yoshifumi Shimada, Kaori Kato, Takeshi Okamoto, Hajime Umezu, Emmanuel Gabriel, Masanori Tsuchida, Toshifumi Wakai

    Surgical case reports   5 ( 1 )   12 - 12   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomal dominant disease of the skin and soft tissue. Aneurysms associated with NF1 can occur, but a secondary aneurysm rupture is very rare, with very few cases reported in literature. CASE PRESENTATION: We describe the case of a 67-year-old female with NF1 who underwent endovascular aneurysm repair (EVAR) for an abdominal aortic aneurysm (AAA) rupture. She developed a type Ib endoleak requiring a redo-EVAR. Eighteen days after her primary operation, she was found to have two new left colic artery aneurysms. She required emergency surgery consisting of a left hemicolectomy and transverse colon colostomy. Pathology showed neurofibromatous changes to the peri-vasculature tissue, consistent with her underlying disease. CONCLUSIONS: Although rare, secondary aneurysms can occur following AAA repair. Patients with soft tissue connective tissue disorders, like NF1, may be at an increased risk for development of these secondary aneurysms. Endovascular repair appears to be a safe approach for NF1 patients with AAA, but endovascular management can be challenging in the setting of NF1. Surgeons should be ready to convert to open surgery if the patient displays persistent signs of bleeding or structural changes related to connective tissue disorders like NF1.

    DOI: 10.1186/s40792-019-0570-4

    PubMed

    researchmap

  • 心不全によるサルコペニアから離脱できた1例

    和田 理澄, 木村 新平, 尾崎 和幸, 加瀬 真弓, 西田 耕太, 久保田 直樹, 高野 俊樹, 大久保 健志, 高山 亜美, 保屋野 真, 柳川 貴央, 小澤 拓也, 柏村 健, 南野 徹, 三島 健人, 榎本 貴士, 大西 遼, 長澤 綾子, 岡本 竹司, 土田 正則

    新潟医学会雑誌   133 ( 1 )   39 - 39   2019.1

     More details

    Language:Japanese   Publisher:新潟医学会  

    researchmap

  • すりガラス結節とFDG陰性の充実性結節を呈した腺様嚢胞癌肺転移の一例

    本田 母映, 山崎 元彦, 八木 琢也, 石川 浩志, 吉村 宣彦, 青山 英史, 佐藤 征二郎, 小池 輝元, 土田 正則, 梅津 哉

    核医学   55 ( Suppl. )   S201 - S201   2018.11

     More details

    Language:English   Publisher:(一社)日本核医学会  

    researchmap

  • 特発性肺線維症を合併した肺癌手術の安全性と予後に関する多施設前向き観察研究 新潟県呼吸器外科研究グループ

    後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 岡田 英, 須田 一晴, 古屋敷 剛, 青木 正, 吉谷 克雄, 大和 靖, 小池 輝明, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 7 )   782 - 791   2018.11

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    【対象と方法】2009年2月〜2015年3月の新潟呼吸器外科研究グループでの特発性肺線維症(IPF)合併肺癌手術例において、術後及び遠隔期の急性増悪(AE)の発生と予後を前向きに検討した。【結果】対象は48例で、男/女47/1例、平均年齢70歳。術後AEは3例(6%)に認め、その内1例が再AEで、2例が再々AEで死亡していた。単変量解析で、術後AEに対する予測因子はなく、遠隔期AEに関しては術後AE発症が予測因子であった。遠隔期AEは、平均16ヵ月で14例(29%)に発症し、8例がAEにより死亡していた。術後AE発症群と非発症群の3年全生存率(OS)は0%、70.6%で(p<0.001)、遠隔期AE発症群と非発症群の3年OSは35.7%、80.3%であった(p=0.001)。【結語】術後AE発症のみが遠隔期AE発症の予測因子であった。遠隔期AEを念頭に置いた注意深い経過観察が必要である。(著者抄録)

    researchmap

  • Common driver mutations and smoking history affect tumor mutation burden in lung adenocarcinoma. Reviewed International journal

    Nagahashi M, Sato S, Yuza K, Shimada Y, Ichikawa H, Watanabe S, Takada K, Okamoto T, Okuda S, Lyle S, Takabe K, Tsuchida M, Wakai T

    The Journal of surgical research   230   181 - 185   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Recent progress in genomic analysis using next-generation sequencing technology has enabled the comprehensive detection of mutations and tumor mutation burden (TMB) in patients. A high TMB (TMB-H) tumor is defined as one with high somatic mutational rates, which correlates with clinical responses to certain treatments such as immunotherapies. We determined TMB in lung adenocarcinoma and clarified the characteristics of patients with TMB-H in relation to common driver mutations and smoking history. MATERIALS AND METHODS: Genomic aberrations and TMB were determined in Japanese patients with lung adenocarcinoma (n = 100) using next-generation sequencing of 415 known cancer genes. TMB-H was defined as > 20 mutations per megabase (Mb) of sequenced DNA. RESULTS: The median TMB was 13.5 (5-33) mutations/Mb. Ten of 100 (10%) patients showed TMB-H, and the others showed low TMB (TMB-L). Only two of 10 (20%) patients with TMB-H had one of the common driver mutations (ALK and ERBB2 mutation), whereas 57 of 90 (63%) patients with TMB-L had one of the driver mutations, including ALK, EGFR, ERBB2, ROS, RET, and MET (P < 0.05). Notably, no EGFR mutation was observed in patients with TMB-H. Eight of 10 (80%) patients with TMB-H had recent smoking history, whereas only 17 of 90 (19%) patients with TMB-L had recent smoking history (P < 0.001). CONCLUSIONS: We found that TMB-H is associated with smoking history, whereas TMB-L is associated with the common driver mutations in lung adenocarcinoma, which may impact treatment strategies for these patients.

    DOI: 10.1016/j.jss.2018.07.007

    PubMed

    researchmap

  • 気腫病変の存在は肺癌手術成績を予測できるか

    中村 将弥, 佐藤 征二郎, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    肺癌   58 ( 6 )   766 - 766   2018.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 術後再発形式から見る早期非小細胞肺癌に対する区域切除の妥当性の検討

    小池 輝元, 仲村 亮宏, 清水 勇希, 後藤 達哉, 佐藤 征二郎, 土田 正則

    肺癌   58 ( 6 )   532 - 532   2018.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 肺多形癌に対してペムブロリズマブが奏効した1例

    羽入 龍太郎, 岡島 正明, 朝川 勝明, 小原 竜軌, 寺田 正樹, 小池 輝元, 土田 正則, 梅津 哉

    肺癌   58 ( 6 )   750 - 750   2018.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 多臓器合併切除の新しいアプローチ/診療科をまたぐ合併切除の試み 大動脈浸潤肺癌に対する人工心肺を用いないTEVAR下大動脈合併切除

    土田 正則, 中村 将弥, 仲村 亮宏, 清水 勇希, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 岡本 竹司, 小池 輝元

    肺癌   58 ( 6 )   445 - 445   2018.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study. International journal

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe, Masanori Tsuchida

    BMC pulmonary medicine   18 ( 1 )   134 - 134   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this study was to evaluate the surgical outcomes of repeated lung cancer surgery in patients with IPF. METHODS: From January 2001 to December 2015, 108 lung cancer patients with IPF underwent pulmonary resection at two institutions; 13 of these patients underwent repeated surgery for lung cancer, and their data were reviewed. RESULTS: The initial procedures of the 13 patients were lobectomy in 8, segmentectomy in 2, and wedge resection in 3. The subsequent procedures were wedge resection in 10 and segmentectomy in 3. The clinical stage of the second tumor was stage IA in 12 and stage IB in 1. Postoperatively, 3 patients (23.1%) developed acute exacerbation (AE) of IPF and died. The rate of decrease in percent vital capacity was significantly higher in patients with AE than in those without AE (p = 0.011). The 3-year overall survival rate was 34.6%. The causes of death were cancer-related in 7, AE of IPF in 3, and metachronous lung cancer in 1. CONCLUSIONS: Despite limited resection, a high incidence of AE was identified. The early and long-term outcomes of repeated surgery in lung cancer patients with IPF were poor because of the high risk of AE of IPF and lung cancer recurrence. Long-term intensive surveillance will be required to determine whether surgical intervention is justified in patients with multiple primary lung cancers and IPF.

    DOI: 10.1186/s12890-018-0703-8

    PubMed

    researchmap

  • Clinical and Genetic Implications of Mutation Burden in Squamous Cell Carcinoma of the Lung. Reviewed International journal

    Okamoto T, Takada K, Sato S, Toyokawa G, Tagawa T, Shoji F, Nakanishi R, Oki E, Koike T, Nagahashi M, Ichikawa H, Shimada Y, Watanabe S, Kikuchi T, Akazawa K, Lyle S, Takabe K, Okuda S, Sugio K, Wakai T, Tsuchida M, Maehara Y

    Annals of surgical oncology   25 ( 6 )   1564 - 1571   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Lung squamous cell carcinoma (LSCC) is a major histological subtype of lung cancer. In this study, we investigated genomic alterations in LSCC and evaluated the clinical implications of mutation burden (MB) in LSCC. METHODS: Genomic alterations were determined in Japanese patients with LSCC (N = 67) using next-generation sequencing of 415 known cancer genes. MB was defined as the number of non-synonymous mutations per 1 Mbp. Programmed death-ligand 1 (PD-L1) protein expression in cancer cells was evaluated by immunohistochemical analysis. RESULTS: TP53 gene mutations were the most common alteration (n = 51/67, 76.1%), followed by gene alterations in cyclin-dependent kinase inhibitor 2B (CDKN2B; 35.8%), CDKN2A (31.3%), phosphatase and tensin homolog (30.0%), and sex-determining region Y-box 2 (SOX2, 28.3%). Histological differentiation was significantly poorer in tumors with high MB (greater than or equal to the median MB) compared with that in tumors with low MB (less than the median MB; p = 0.0446). The high MB group had more tumors located in the upper or middle lobe than tumors located in the lower lobe (p = 0.0019). Moreover, cancers in the upper or middle lobes had significantly higher MB than cancers in the lower lobes (p = 0.0005), and tended to show higher PD-L1 protein expression (p = 0.0573). SOX2 and tyrosine kinase non-receptor 2 amplifications were associated with high MB (p = 0.0065 and p = 0.0010, respectively). CONCLUSIONS: The MB level differed according to the tumor location in LSCC, suggesting that the location of cancer development may influence the genomic background of the tumor.

    DOI: 10.1245/s10434-018-6401-1

    PubMed

    researchmap

  • Surgical resection of a giant polycystic seminoma of the mediastinum. International journal

    Tatsuya Goto, Seijiro Sato, Terumoto Koike, Masanori Tsuchida

    Journal of thoracic disease   10 ( 6 )   E438-E441   2018.6

     More details

  • Strategy of intentional limited resection for lung adenocarcinoma in situ. International journal

    Terumoto Koike, Teruaki Koike, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Seijiro Sato, Masanori Tsuchida

    Journal of thoracic disease   10 ( Suppl 17 )   S2018-S2021   2018.6

     More details

  • 下大静脈腫瘍塞栓を伴う腎細胞癌に対する手術症例の検討

    名村 理, 仲村 亮宏, 鈴木 脩平, 大西 遼, 中村 制士, 長澤 綾子, 岡本 竹司, 青木 賢治, 榛澤 和彦, 土田 正則

    日本血管外科学会雑誌   27 ( Suppl. )   O24 - 3   2018.6

     More details

    Language:Japanese   Publisher:(NPO)日本血管外科学会  

    researchmap

  • 術前動脈塞栓術を行い切除した胸腔内巨大孤立性線維性腫瘍の1例

    清水 勇希, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 177回 )   21 - 21   2018.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 左肺全摘術と右主肺動脈再建にて完全切除した左主肺動脈血管肉腫の1手術例

    北原 哲彦, 清水 勇希, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 4 )   492 - 499   2018.5

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    症例は64歳女性。子宮体癌の破裂により当院を受診した。緊急で子宮切除が行われたが、その際のCTで深部静脈血栓と右肺動脈血栓、左肺動脈内の塞栓子を認めた。子宮体癌術後下大静脈フィルターと抗凝固薬にて治療が行われた。抗凝固療法により右肺動脈内の血栓は消失したが、左肺動脈の塞栓子は消失しなかった。その後塞栓子は徐々に増大を認めた。PET/CTでは同病変に集積を認め、心臓カテーテル検査での腫瘍生検により血管肉腫と診断された。胸骨正中切開で体外循環を併用し、左主肺動脈切除と左肺全摘、右主肺動脈再建を行った。病理では血管内膜由来の肉腫であることが判明した。術後8ヵ月目に再発を認め、9ヵ月後に肺炎による呼吸不全で死亡した。肺動脈肉腫は稀な疾患であり、文献的考察を加え報告する。(著者抄録)

    researchmap

    Other Link: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J02256&link_issn=&doc_id=20180523320010&doc_link_id=10.2995%2Fjacsurg.32.492&url=https%3A%2F%2Fdoi.org%2F10.2995%2Fjacsurg.32.492&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • A proposal for a comprehensive risk scoring system for predicting postoperative complications in octogenarian patients with medically operable lung cancer: JACS1303. Reviewed International journal

    Hisashi Saji, Takahiko Ueno, Hiroshige Nakamura, Norihito Okumura, Masanori Tsuchida, Makoto Sonobe, Takuro Miyazaki, Keiju Aokage, Masayuki Nakao, Tomohiro Haruki, Hiroyuki Ito, Kazuhiko Kataoka, Kazunori Okabe, Kenji Tomizawa, Kentaro Yoshimoto, Hirotoshi Horio, Kenji Sugio, Yasuhisa Ode, Motoshi Takao, Morihito Okada, Masayuki Chida

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery   53 ( 4 )   835 - 841   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: Although some retrospective studies have reported clinicopathological scoring systems for predicting postoperative complications and survival outcomes for elderly lung cancer patients, optimized scoring systems remain controversial. METHODS: The Japanese Association for Chest Surgery (JACS) conducted a nationwide multicentre prospective cohort and enrolled a total of 1019 octogenarians with medically operable lung cancer. Details of the clinical factors, comorbidities and comprehensive geriatric assessment were recorded for 895 patients to develop a comprehensive risk scoring (RS) system capable of predicting severe complications. RESULTS: Operative (30 days) and hospital mortality rates were 1.0% and 1.6%, respectively. Complications were observed in 308 (34%) patients, of whom 81 (8.4%) had Grade 3-4 severe complications. Pneumonia was the most common severe complication, observed in 27 (3.0%) patients. Five predictive factors, gender, comprehensive geriatric assessment75: memory and Simplified Comorbidity Score (SCS): diabetes mellitus, albumin and percentage vital capacity, were identified as independent predictive factors for severe postoperative complications (odds ratio = 2.73, 1.86, 1.54, 1.66 and 1.61, respectively) through univariate and multivariate analyses. A 5-fold cross-validation was performed as an internal validation to reconfirm these 5 predictive factors (average area under the curve 0.70). We developed a simplified RS system as follows: RS = 3 (gender: male) + 2 (comprehensive geriatric assessment 75: memory: yes) + 2 (albumin: <3.8 ng/ml) + 1 (percentage vital capacity: ≤90) + 1 (SCS: diabetes mellitus: yes). CONCLUSIONS: The current series shows that octogenarians can be successfully treated for lung cancer with surgical resection with an acceptable rate of severe complications and mortality. We propose a simplified RS system to predict severe complications in octogenarian patients with medically operative lung cancer. Trial Registration Number: JACS1303 (UMIN000016756).

    DOI: 10.1093/ejcts/ezx415

    PubMed

    researchmap

  • 臨床病期I期原発性肺癌における区域切除後の再発に関する検討

    仲村 亮宏, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本外科学会定期学術集会抄録集   118回   2518 - 2518   2018.4

     More details

    Language:Japanese   Publisher:(一社)日本外科学会  

    researchmap

  • 半定量的CT評価法に基づく気腫病変存在程度から観た原発性肺癌手術成績

    佐藤 征二郎, 清水 勇希, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 3 )   O4 - 1   2018.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 半定量的CT評価法に基づく気腫病変存在程度から観たCOPD合併肺癌の検討

    清水 勇希, 佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 3 )   O9 - 6   2018.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • リンパ節転移を有する扁平上皮癌患者の再発・予後に関する検討

    後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 3 )   P11 - 2   2018.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 第2肺癌に対する術後合併症リスクについて考える

    佐藤 征二郎, 清水 勇希, 仲村 亮宏, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則

    日本外科学会定期学術集会抄録集   118回   2148 - 2148   2018.4

     More details

    Language:Japanese   Publisher:(一社)日本外科学会  

    researchmap

  • 末梢小型肺癌における区域切除後遠隔期の課題 病理学的浸潤・転移のリスク因子を有する早期非小細胞肺癌患者に対する縮小手術の成績

    小池 輝元, 清水 勇希, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 3 )   PD2 - 6   2018.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • SVC合併切除・グラフト置換を施行した胸腺癌の1手術例

    清水 勇希, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 176回 )   21 - 21   2018.3

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • HRCT texture analysis for pure or part-solid ground-glass nodules: distinguishability of adenocarcinoma in situ or minimally invasive adenocarcinoma from invasive adenocarcinoma. Reviewed

    Yagi T, Yamazaki M, Ohashi R, Ogawa R, Ishikawa H, Yoshimura N, Tsuchida M, Ajioka Y, Aoyama H

    Japanese journal of radiology   36 ( 2 )   113 - 121   2018.2

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s11604-017-0711-2

    PubMed

    researchmap

    Other Link: http://link.springer.com/content/pdf/10.1007/s11604-017-0711-2.pdf

  • 肺動脈塞栓として初期治療を受け、18F FDG-PET/CTで鑑別できた肺動脈肉腫の1例

    山田 美佳, 佐藤 卓, 石川 浩志, 堀井 陽祐, 八木 琢也, 山崎 元彦, 塩谷 基, 吉村 宣彦, 青山 英史, 佐藤 征二郎, 小池 輝元, 土田 正則, 名村 理, 大橋 瑠子, 梅津 哉

    Japanese Journal of Radiology   36 ( Suppl. )   7 - 7   2018.2

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • 特異な進展を示した類基底細胞癌の1例

    鈴木 脩平, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    肺癌   58 ( 1 )   69 - 69   2018.2

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • Impact of Concurrent Genomic Alterations Detected by Comprehensive Genomic Sequencing on Clinical Outcomes in East-Asian Patients with EGFR-Mutated Lung Adenocarcinoma. Reviewed International journal

    Sato S, Nagahashi M, Koike T, Ichikawa H, Shimada Y, Watanabe S, Kikuchi T, Takada K, Nakanishi R, Oki E, Okamoto T, Akazawa K, Lyle S, Ling Y, Takabe K, Okuda S, Wakai T, Tsuchida M

    Scientific reports   8 ( 1 )   1005 - 1005   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Next-generation sequencing (NGS) has enabled comprehensive detection of genomic alterations in lung cancer. Ethnic differences may play a critical role in the efficacy of targeted therapies. The aim of this study was to identify and compare genomic alterations of lung adenocarcinoma between Japanese patients and the Cancer Genome Atlas (TCGA), which majority of patients are from the US. We also aimed to examine prognostic impact of additional genomic alterations in patients harboring EGFR mutations. Genomic alterations were determined in Japanese patients with lung adenocarcinoma (N = 100) using NGS-based sequencing of 415 known cancer genes, and correlated with clinical outcome. EGFR active mutations, i.e., those involving exon 19 deletion or an L858R point mutation, were seen in 43% of patients. Some differences in driver gene mutation prevalence were observed between the Japanese cohort described in the present study and the TCGA. Japanese cohort had significantly more genomic alterations in cell cycle pathway, i.e., CDKN2B and RB1 than TCGA. Concurrent mutations, in genes such as CDKN2B or RB1, were associated with worse clinical outcome in patients with EGFR active mutations. Our data support the utility of comprehensive sequencing to detect concurrent genomic variations that may affect clinical outcomes in this disease.

    DOI: 10.1038/s41598-017-18560-y

    PubMed

    researchmap

  • Efficacy and Safety of Pancreas-Targeted Hydrodynamic Gene Delivery in Rats Reviewed

    Kohei Ogawa, Kenya Kamimura, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Norihiro Sakai, Takuro Nagoya, Akira Sakamaki, Satoshi Abe, Kazunao Hayashi, Satoshi Ikarashi, Junji Kohisa, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   9   80 - 88   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:CELL PRESS  

    Development of an effective, safe, and convenient method for gene delivery to the pancreas is a critical step toward gene therapy for pancreatic diseases. Therefore, we tested the possibility of applying the principle of hydrodynamic gene delivery for successful gene transfer to pancreas using rats as a model. The established procedure involves the insertion of a catheter into the superior mesenteric vein with temporary blood flow occlusion at the portal vein and hydrodynamic injection of DNA solution. We demonstrated that our procedure achieved efficient pancreas-specific gene expression that was 2,000-fold higher than that seen in the pancreas after the systemic hydrodynamic gene delivery. In addition, the level of gene expression achieved in the pancreas by the pancreas-specific gene delivery was comparable to the level in the liver achieved by a liver-specific hydrodynamic gene delivery. The optimal level of reporter gene expression in the pancreas requires an injection volume equivalent to 2.0% body weight with flow rate of 1 mL/s and plasmid DNA concentration at 5 mu g/mL. With the exception of transient expansion of intercellular spaces and elevation of serum amylase levels, which recovered within 3 days, no permanent tissue damage was observed. These results suggest that pancreas-targeted hydrodynamic gene delivery is an effective and safe method for gene delivery to the pancreas and clinically applicable.

    DOI: 10.1016/j.omtn.2017.08.009

    Web of Science

    PubMed

    researchmap

  • Characteristics and timing of recurrence during postoperative surveillance after curative resection for lung adenocarcinoma Reviewed

    Terumoto Koike, Tatsuya Goto, Akihiko Kitahara, Seijiro Sato, Masayuki Saitoh, Takehisa Hashimoto, Osamu Namura, Masashi Takahashi, Shin-ichi Toyabe, Masanori Tsuchida

    SURGERY TODAY   47 ( 12 )   1469 - 1475   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    To establish the most effective methods of postoperative surveillance to detect early recurrence of lung adenocarcinoma.
    The subjects of this retrospective study were 485 patients with p-stage I-III lung adenocarcinoma, who underwent postoperative surveillance. We examined the sites and detection modes of recurrence and calculated the recurrence-free probabilities. Patients with stage I disease were divided into low- and high-risk recurrence groups using a risk score calculated by assigning points proportional to risk factor regression coefficients.
    Of the 112 patients with recurrence, 86 had intrathoracic recurrence. Routine computed tomography (CT) revealed recurrence in 60 patients. The recurrence-free probability curves showed that 95% of recurrences were identified within the first 4 years after resection in patients with stage II/III disease. In patients with stage I disease, the predictors of recurrence included male sex, positive pleural lavage cytology, moderate-to-poor differentiation, and visceral pleural invasion. Postoperative recurrences were detected throughout the follow-up period in the high-risk group.
    Routine chest CT plays an important role in the postoperative surveillance of lung adenocarcinoma. We recommend intensive follow-up during the early post-resection period for patients with advanced stage disease and long-term follow-up for high-risk patients with stage I disease.

    DOI: 10.1007/s00595-017-1537-3

    Web of Science

    researchmap

  • Predictors of ventricular tachyarrhythmia occurring late after intracardiac repair of tetralogy of Fallot: combination of QRS duration change rate and tricuspid regurgitation pressure gradient. International journal

    Shuichi Shiraishi, Masashi Takahashi, Ai Sugimoto, Masanori Tsuchida

    Journal of thoracic disease   9 ( 12 )   5112 - 5119   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Background: To determine potential predictors of ventricular tachyarrhythmia and sudden cardiac death (SCD) occurring late after repair of tetralogy of Fallot (TOF). Methods: Since 1964, 415 patients had undergone total repair for TOF at Niigata University Hospital. Of these, 89 patients who were followed for more than 10 years at our institute were retrospectively reviewed. Results: The mean follow-up period was 24.3 years. During the study period, one patient died of cerebral bleeding, and two patients had SCD. The overall survival rates at 20, 30, and 40 years were 100%, 94.6%, and 94.6%, respectively. Eight (9.0%) patients required re-intervention during the late period associated with right ventricular outflow (n=4), tricuspid valve (n=3), aortic valve (n=2), and others (n=2). Ten (11.2%) patients had a history of ventricular tachycardia (VT) or ventricular fibrillation (VF), and six underwent implantation of an implantable cardiac defibrillator. Multivariate analysis selected the change rate of QRS duration [ms/year; odds ratio (OR), 2.44; 95% confidence interval (CI): 1.28-4.65; P=0.007] and the pressure gradient at tricuspid valve regurgitation on echocardiography (OR, 1.12; 95% CI: 1.02-1.22; P=0.017) as risk factors for VT/VF or SCD. Trans-annular patch (TAP) repair was not an independent risk factor for ventricular arrhythmia. Conclusions: The combination of rapid change rate of QRS duration and higher-pressure gradient at tricuspid regurgitation were risk factors for ventricular tachyarrhythmia late after TOF repair. Adequate surgical or catheter intervention for pressure and volume load in the right ventricle might decrease the prevalence of VT/VF and SCD.

    DOI: 10.21037/jtd.2017.11.53

    PubMed

    researchmap

  • Endothelial p53 Regulates Vascular Function Under Hyperglycemic and Hypoxic Conditions Reviewed

    Nagasawa Ayako, Shimizu Ippei, Yoshida Yohko, Tsuchida Masanori, Minamino Tohru

    CIRCULATION   136   2017.11

  • One-stage surgery in combination with thoracic endovascular grafting and resection of T4 lung cancer invading the thoracic aorta and spine Reviewed

    Seijiro Sato, Tatsuya Goto, Terumoto Koike, Takeshi Okamoto, Hirokazu Shoji, Masayuki Ohashi, Kei Watanabe, Masanori Tsuchida

    JOURNAL OF THORACIC DISEASE   9 ( 11 )   E1009 - E1012   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AME PUBL CO  

    A novel strategy of one-stage surgery in combination with thoracic endovascular grafting and resection for T4 lung cancer invading the thoracic aorta and spine is described. A 56-year-old man with locally advanced lung cancer infiltrating the aortic wall and spine underwent neoadjuvant chemotherapy and thoracic irradiation, followed by en bloc resection of the aortic wall and spine with thoracic endovascular grafting. He developed postoperative chylothorax, but there were no stent graft-related events. After 3 months, computed tomography (CT) did not show aortic stent graft stenosis, migration, or deformation.

    DOI: 10.21037/jtd.2017.10.101

    Web of Science

    researchmap

  • 単尖弁による大動脈弁閉鎖不全症に対する弁形成術の経験

    大西 遼, 國原 孝, 青木 賢治, 中村 制士, 岡本 竹司, 名村 理, 榛澤 和彦, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 175回 )   7 - 7   2017.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • N2-IIIA期肺腺癌に対して術前導入療法によって左肺全摘を回避しえた1例

    仲村 亮宏, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 175回 )   16 - 16   2017.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 縦隔原発malignant peripheral nerve sheath tumorの1切除例

    清水 勇希, 佐藤 征二郎, 後藤 達哉, 小池 輝元, 土田 正則, 梅津 哉

    肺癌   57 ( 6 )   801 - 801   2017.11

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 臨床試験から視た肺癌手術 日本呼吸器外科学会の主導による臨床研究・前向き登録研究 高齢者肺癌前向き登録研究JACS1303の取り組み

    佐治 久, 上野 隆彦, 中村 廣繁, 奥村 典仁, 土田 正則, 園部 誠, 宮崎 拓郎, 青景 圭樹, 中尾 将之, 春木 朋広, 岡田 守人

    日本臨床外科学会雑誌   78 ( 増刊 )   333 - 333   2017.10

     More details

    Language:Japanese   Publisher:日本臨床外科学会  

    researchmap

  • 生体肺移植遠隔期の高度BOSにおける繰り返す無気肺の1例

    後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    移植   52 ( 2-3 )   246 - 246   2017.9

     More details

    Language:Japanese   Publisher:(一社)日本移植学会  

    researchmap

  • 次世代シーケンサーを用いた併存遺伝子変異の影響

    佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 高田 和樹, 岡本 龍郎, 土田 正則

    肺癌   57 ( 5 )   555 - 555   2017.9

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • [Perioperative Management for Prevention of Cardiac Complications in General Thoracic Surgery].

    Terumoto Koike, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   70 ( 8 )   639 - 642   2017.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    For general thoracic surgeons, perioperative management for prevention of cardiac complications is important because patients undergoing general thoracic surgery often have risk factors for cardiac disease. Sever cardiac failure should be detected and treated prior to surgery, and coronary artery may be examined in patients with risk factors for ischemic heart disease. Pulmonary resection sometimes causes right-sided heart failure due to reducing pulmonary vascular bed. In high-risk patients for rightsided heart failure, pulmonary artery pressure monitoring by right heart catheterization should be considered in addition to blood pressure and central venous pressure monitoring, and precise fluid management is required. Because perioperatively occurred myocardial infarction is sometimes lethal, patients with preoperatively identified significant coronary artery stenosis, percutaneous coronary intervention or coronary artery bypass grafting should be considered although surgeons need to be careful for the timing of surgery and anticoagulant therapy. Even if patients have no typical symptoms, perioperative myocardial infarction can be diagnosed 12-lead electrocardiogram and serum biomarkers. Cooperation with cardiologists is necessary for the treatment of perioperative myocardial infarction. Although arrhythmia is one of the major complications after general thoracic surgery, arrhythmia with hemodynamic instability should be immediately treated. Early diagnosis and management of cardiovascular events can minimize the consequences of these complications.

    PubMed

    researchmap

  • 【胸部外科領域における合併症予防のための周術期管理】呼吸器領域 心機能障害による合併症予防のための術中・術後管理の要点

    小池 輝元, 土田 正則

    胸部外科   70 ( 8 )   639 - 642   2017.7

  • 左上葉切除後の異時多発肺がんSBRT後再発に対する残存肺全摘、大動脈合併切除の1例

    田代 啓太, 仲村 亮宏, 後藤 達哉, 中村 制士, 佐藤 征二郎, 岡本 竹司, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 174回 )   8 - 8   2017.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway Reviewed

    Daisuke Kinoshita, Ayako Nagasawa, Ippei Shimizu, Takashi K. Ito, Yohko Yoshida, Masanori Tsuchida, Atsushi Iwama, Toshiya Hayano, Tohru Minamino

    ONCOTARGET   8 ( 21 )   34045 - 34056   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IMPACT JOURNALS LLC  

    Mutations of the lamin A gene cause various premature aging syndromes, including Hutchinson-Gilford progeria syndrome (HGPS) and atypical Werner syndrome. In HGPS (but not atypical Werner syndrome), extensive loss of vascular smooth muscle cells leads to myocardial infarction with premature death. The underlying mechanisms how single gene mutations can cause various phenotypes are largely unknown. We performed an interactome analysis using mutant forms of lamin A involved in progeroid syndromes. We found that the mutant lamin A responsible for HGPS, known as progerin, could not bind to proteins related to the DNA damage response, including DNA-dependent protein kinase (DNA-PK). In contrast, wild-type lamin A and lamin A mutants causing atypical Werner syndrome were able to bind to these molecules. We also found that forced expression of progerin in vascular smooth muscle cells led to activation of DNA-PK and cellular growth arrest, while knockdown of DNA-PK attenuated this. Deletion of p53 also improved the inhibition of cell growth due to forced expression of progerin. These findings suggested that progerin activates the DNA damage response pathway and that dysregulation of this pathway may be responsible for the development of cardiovascular pathology in patients with HGPS.

    DOI: 10.18632/oncotarget.15973

    Web of Science

    PubMed

    researchmap

  • A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer Reviewed

    Yoshiaki Inoue, Jun Shiihara, Hitoshi Miyazawa, Hiromitsu Ohta, Megumi Higo, Yoshiaki Nagai, Kunihiko Kobayashi, Yasuo Saijo, Masanori Tsuchida, Mitsuo Nakayama, Koichi Hagiwara

    PLOS ONE   12 ( 4 )   e0176525   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PUBLIC LIBRARY SCIENCE  

    Molecular targeting therapy for non-small cell lung cancer (NSCLC) has clarified the importance of mutation testing when selecting treatment regimens. As a result, multiple-gene mutation tests are urgently needed. We developed a next-generation sequencer (NGS)-based, multi-gene test named the MINtS for investigating driver mutations in both cytological specimens and snap-frozen tissue samples. The MINtS was used to investigate the EGFR, KRAS, BRAF genes from DNA, and the ERBB2, and the ALK, ROS1, and RET fusion genes from RNA. We focused on high specificity and sensitivity (&gt;= 0.99) and even included samples with a cancer cell content of 1%. The MINtS enables testing of more than 100 samples in a single run, making it possible to process a large number of samples submitted to a central laboratory, and reducing the cost for a single sample. We investigated 96 cytological samples and 190 surgically resected tissues, both of which are isolated in daily clinical practice. With the cytological samples, we compared the results for the EGFR mutation between the MINtS and the PNA-LNA PCR clamp test, and their results were 99% consistent. In the snap-frozen tissue samples, 188/190 (99%) samples were successfully analyzed for all genes investigated using both DNA and RNA. Then, we used 200 cytological samples that were serially isolated in clinical practice to assess RNA quality. Using our procedure, 196 samples (98%) provided high-quality RNA suitable for analysis with the MINtS. We concluded that the MINtS test system is feasible for analyzing ''druggable'' genes using cytological samples and snap-frozen tissue samples. The MINtS will fill a needs for patients for whom only cytological specimens are available for genetic testing.

    DOI: 10.1371/journal.pone.0176525

    Web of Science

    PubMed

    researchmap

  • 巨大anterior mediastinal cystic seminomaの1手術例

    北原 哲彦, 仲村 亮宏, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    肺癌   57 ( 2 )   131 - 131   2017.4

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 左肺全摘術+右主肺動脈再建にて完全切除した左主肺動脈intimal sarcomaの1手術例

    後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   31 ( 3 )   RV1 - 3   2017.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 局所進行T4肺癌に対する大動脈遠位弓部合併切除および椎体合併切除再建術

    佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   31 ( 3 )   RV4 - 6   2017.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • NSCLC切除例におけるPET/CTを用いたMetabolic tumor volumeとTotal lesion glycolysisの有用性の検討

    後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   31 ( 3 )   P82 - 3   2017.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 周囲臓器の高度圧排を認めた巨大右肺癌の1手術例

    後藤 達哉, 佐藤 征二郎, 小池 輝元, 名村 理, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 173回 )   24 - 24   2017.3

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 多発肺結節を呈したメトトレキセート関連リンパ増殖性疾患の1例

    山名 加菜子, 山崎 元彦, 石川 浩志, 八木 琢也, 吉村 宣彦, 青山 英史, 坂上 拓郎, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則, 大橋 瑠子, 梅津 哉

    Japanese Journal of Radiology   35 ( Suppl. )   8 - 8   2017.2

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • 若年者に発症し副結節をともなった硬化性血管腫の1例

    押金 智哉, 山崎 元彦, 石川 浩志, 八木 琢也, 吉村 宣彦, 青山 英史, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則, 大橋 瑠子, 梅津 哉

    Japanese Journal of Radiology   35 ( Suppl. )   8 - 8   2017.2

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • 持続グルコースモニタを用いた心臓手術中の糖変動の解析

    佐藤 裕喜, 青木 賢治, 石川 友美, 細島 康宏, 長澤 綾子, 岡本 竹司, 名村 理, 榛沢 和彦, 土田 正則

    日本心臓血管外科学会学術総会抄録集   47回   920 - 920   2017.2

     More details

    Language:Japanese   Publisher:(NPO)日本心臓血管外科学会  

    researchmap

  • Glucose Variability Based on Continuous Glucose Monitoring Assessment Is Associated with Postoperative Complications after Cardiovascular Surgery Reviewed

    Hiroki Sato, Michihiro Hosojima, Tomomi Ishikawa, Kenji Aoki, Takeshi Okamoto, Akihiko Saito, Masanori Tsuchida

    ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY   23 ( 5 )   239 - 247   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MEDICAL TRIBUNE INC  

    Purpose: This purpose of this prospective study was to use a continuous glucose monitoring (CGM) system to evaluate the suitability of our institution's glucose management protocol after cardiovascular surgery and to clarify the impact of glycemic variability on postoperative complications.
    Methods: In all, 76 patients who underwent elective cardiovascular surgery and were monitored perioperatively using a CGM system were evaluated. Postoperative glucose management consisted of continuous intravenous insulin infusion (CIII) in the intensive care unit, and subcutaneous insulin injections (SQII) after oral food intake started. CIII and subcutaneous injections were initiated when blood glucose level exceeded 150 mg/dL. CGM data were used to analyze perioperative glycemic variability and association with postoperative complications.
    Results: Target glucose levels (71-180 mg/dL) were achieved during 97.1 +/- 5.5% and 86.4 +/- 19.0% of the continuous insulin infusion and subcutaneous injection periods, respectively. Major postoperative complications were surgical site infections, found in 6.6% of total patients, and atrial fibrillation, found in 44% of patients with off-pump coronary artery bypass grafting. High glycemic variability during SQII was associated with increased risk for both complications.
    Conclusion: Data analysis revealed that our glucose management protocol during CIII was adequate. However, the management protocol during SQII required improvement.

    DOI: 10.5761/atcs.oa.17-00045

    Web of Science

    PubMed

    researchmap

  • Non-bacterial thrombotic endocarditis in the right atrium caused by pectus excavatum. International journal

    Ai Sugimoto, Shuichi Shiraishi, Maya Watanabe, Jiyong Moon, Riuko Ohashi, Masashi Takahashi, Masanori Tsuchida

    Surgical case reports   2 ( 1 )   105 - 105   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Non-bacterial thrombotic endocarditis (NBTE) is an uncommon pathological situation, which involves the presence of bland, fibrin-platelet thrombi. It usually occurs at the endocardium of cardiac valves, in association with endothelial injury and a hypercoagulative state. However, NBTE on the endocardium at the right atrial free wall in a patient without any apparent hypercoagulative background is rarely reported. CASE PRESENTATION: A girl aged 4 years with severe pectus excavatum was referred to our hospital for treatment of a recurrent right atrial tumor. The tumor was removed concomitant with pectus excavatum repair. The tumor was revealed as recurrent thrombus. Pathological findings showed that NBTE caused by an operative scar on the endocardium of the right atrium and sustained rheological stress in the right atrium due to compression from pectus excavatum lead to recurrent thrombus formation. Three years after the discontinuation of anticoagulation therapy, no sign of thrombus formation was found. CONCLUSIONS: To our knowledge, this is the first report of NBTE related to an interaction between sustained rheological stress from cardiac compression and endocardial injury. In such patients, we recommend concomitant chest wall repair when the operative scar is present at the site of the rheological force.

    DOI: 10.1186/s40792-016-0236-4

    PubMed

    researchmap

  • Lobectomy and limited resection in small-sized peripheral non-small cell lung cancer. Reviewed International journal

    Koike T, Koike T, Sato S, Hashimoto T, Aoki T, Yoshiya K, Yamato Y, Watanabe T, Akazawa K, Toyabe SI, Tsuchida M, Niigata Chest, Surgery Research Group

    Journal of thoracic disease   8 ( 11 )   3265 - 3274   2016.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Although lobectomy is the standard surgical procedure for non-small cell lung cancer (NSCLC), recent studies show favorable outcomes after limited resection in patients with small-sized peripheral tumors. We conducted a randomized controlled trial of such patients to estimate postoperative outcomes and pulmonary function following these surgical techniques. METHODS: Between 2005 and 2008, eligible patients with tumors of 2 cm or less were randomly assigned 1:1 to undergo lobectomy or limited resection; 32 and 33 NSCLC patients in each group, respectively, were analyzed. The primary end points were 5-year overall survival (OS) and disease-free survival (DFS), while the secondary end points were postoperative pulmonary function including forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). RESULTS: The 5-year OS rates were 93.8% and 90.9% in the lobectomy and limited resection groups, respectively (P=0.921). The 5-year DFS rates were 93.8% and 90.9% in the lobectomy and limited resection groups, respectively (P=0.714). These rates did not differ significantly between the two resection groups. The median postoperative/preoperative FVC ratios were 84.1% and 90.0% in the lobectomy and limited resection groups, respectively, while the median postoperative/preoperative FEV1 ratios were 81.9% and 89.1%, respectively. Both ratios were significantly higher in the limited resection group (P=0.032 and P=0.005 for FVC and FEV1 ratios, respectively). CONCLUSIONS: A similar outcome, with more preserved postoperative pulmonary function, was observed in patients who underwent limited resection compared to those who underwent lobectomy. Ongoing large-scale multi-institutional prospective randomized trials of lobar versus sublobar resection in patients with small peripheral NSCLCs will hopefully provide definitive information about intentional limited resection of small peripheral tumors.

    DOI: 10.21037/jtd.2016.11.106

    PubMed

    researchmap

  • Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma Reviewed

    Ye Xulu, Zhou Qiliang, Matsumoto Yoshifumi, Moriyama Masato, Kageyama Shun, Komatsu Masaaki, Satoh Seijiro, Tsuchida Masanori, Saijo Yasuo

    ANTICANCER RESEARCH   36 ( 11 )   6021 - 6029   2016.11

  • Coronary Ostioplasty for Congenital Atresia of the Left Main Coronary Artery Ostium in a Teenage Boy. International journal

    Ai Sugimoto, Shuichi Shiraishi, Jiyong Moon, Masashi Takahashi, Masanori Tsuchida

    World journal for pediatric & congenital heart surgery   7 ( 6 )   773 - 776   2016.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Atresia of the left coronary artery ostium is extremely rare. We report the case of a 13-year-old boy who played volleyball in school and collapsed with severe chest pain during practice. He was referred to our hospital, and imaging modalities showed atresia of the left main coronary artery ostium. Urgent coronary ostioplasty was performed using a patch of 0.6% glutaraldehyde-treated autologous pericardium. His postoperative course was uneventful, and he has had a normal everyday life without chest pain 8 months postoperatively. Physicians should be aware of the patient's history, as in this case, because prompt imaging diagnosis is essential when there is a high likelihood that the event is related to myocardial ischemia. Since long-term outcome is uncertain even after successful surgical revascularization, close follow-up is required.

    PubMed

    researchmap

  • 次世代シーケンサーを用いた原発性肺腺癌切除例の網羅的遺伝子発現解析に基づく治療

    佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 高田 和樹, 岡本 龍郎, 前原 喜彦, 土田 正則

    肺癌   56 ( 6 )   515 - 515   2016.11

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 術前生検にて診断がついた左主肺動脈血管肉腫の1手術例

    後藤 達哉, 仲村 亮宏, 大久保 由華, 佐藤 征二郎, 小池 輝元, 白石 修一, 名村 理, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 172回 )   21 - 21   2016.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • [Fatal Respiratory Failure Developed during Chemotherapy for Diffuse Large B Cell Lymphoma that Occurred Late after Lung Transplantation].

    Akihiko Kitahara, Seijiro Sato, Terumoto Koike, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   69 ( 11 )   941 - 945   2016.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    We report here a case of fatal respiratory failure developed during chemotherapy for diffuse large B cell lymphoma that occurred late after lung transplantation. 25-year- old man underwent lung transplantation from brain death donor for respiratory failure due to interstitial pneumonia at the age of 16 years old. Two years after transplantation, his respiratory function decreased gradually. Chronic lung allograft dysfunction including bronchiolitis obliterans( BOS) and restrictive allograft syndrome was suspected and immunosuppression was enhanced. Nine years after transplantation, he had abdominal pain and physical examination suggested intestinal obstruction. Small intestine endoscopy revealed an ulcer at jejunum and diffuse large B cell lymphoma( DLBCL) was finally diagnosed by biopsy. Chemotherapy was planned for lymphoma, but respiratory failure progressed just before chemotherapy. Chest computed tomography showed infiltrative shadow in right lung, so we suspected presence of lymphoma and chemotherapy was carried out. After chemotherapy, abnormal shadow in the right lung disappeared. Although chemotherapy was effective, respiratory failure progressed and he died. Pathological examination from autopsy showed mixture of BOS, diffuse alveolar damage, invasion of aspergillus and acute fibrinoid organizing pneumonia but no residual DLBCL was found in the lung.

    PubMed

    researchmap

  • 【肺移植における周術期・遠隔期の課題】慢性期移植肺機能不全と悪性腫瘍 肺移植後遠隔期発症のびまん性大細胞型B細胞リンパ腫に併発した致死的呼吸不全

    北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    胸部外科   69 ( 11 )   941 - 945   2016.10

     More details

    Language:Japanese   Publisher:(株)南江堂  

    25歳男。幼少期より間質性肺炎にて加療されるも呼吸不全が進行し、16歳時に海外で脳死両側肺移植を受けていた。その後、閉塞性細気管支炎とrestrictive allograft syndromeの混在した慢性期移植肺機能不全の状態となり、免疫抑制剤の投与にて経過観察されていた。今回、腹痛、嘔吐が出現し、小腸内視鏡で空腸に潰瘍性病変を認めた。生検の結果、びまん性大細胞型B細胞リンパ腫と診断され、化学療法待機中に呼吸不全の進行を認めた。胸部CTでは右肺門部を中心とした浸潤影を認め、臨床経過よりリンパ腫の肺病変と判断し、化学療法を行う方針とした。化学療法直前に呼吸不全が進行したため、人工呼吸器管理下に抗真菌薬を併用して化学療法を開始した。1コース目終了時に右肺門部浸潤影はほぼ消失したが、その後、真菌感染症と呼吸不全を来たし43日目(両側肺移植後9年8ヵ月目)に死亡した。

    researchmap

    Other Link: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J00349&link_issn=&doc_id=20161011120016&doc_link_id=1390002209966314112&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390002209966314112&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_2.gif

  • Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery Reviewed

    Yuji Kobayashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Yokoo, Kohei Ogawa, Yoko Shinagawa-Kobayashi, Ryo Goto, Ryosuke Inoue, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   5 ( 8 )   e359   2016.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:CELL PRESS  

    Hydrodynamic gene delivery is a common method for gene transfer to the liver of small animals, and its clinical applicability in large animals has been demonstrated. Previous studies focused on functional analyses of therapeutic genes in animals with normal livers and little, however, is known regarding its effectiveness and safety in animals with liver fibrosis. Therefore, this study aimed to examine the effects of liver fibrosis on hydrodynamic gene delivery efficiency using a rat liver fibrosis model. We demonstrated for the first time, using pCMV-Luc plasmid, that this procedure is safe and that the amount of fibrotic tissue in the liver decreases gene delivery efficiency, resulting in decrease in luciferase activity depending on the volume of fibrotic tissue in the liver and the number of hepatocytes that are immunohistochemically stained positive for transgene product. We further demonstrate that antifibrotic gene therapy with matrix metalloproteinase-13 gene reduces liver fibrosis and improves efficiency of hydrodynamic gene delivery. These results demonstrate the negative effects of fibrotic tissue on hydrodynamic gene delivery and its recovery by appropriate antifibrotic therapy.

    DOI: 10.1038/mtna.2016.63

    Web of Science

    PubMed

    researchmap

  • 肺移植後びまん性大細胞性B細胞性リンパ腫を発症し、治療中に致死的肺アスペルギルス症を合併した1例

    北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    移植   51 ( 2-3 )   240 - 240   2016.8

     More details

    Language:Japanese   Publisher:(一社)日本移植学会  

    researchmap

  • 若年女性に発症した多発肺硬化性血管腫の1例

    仲村 亮宏, 佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則, 梅津 哉

    肺癌   56 ( 4 )   326 - 326   2016.8

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 橈骨動脈外膜嚢腫の1手術例

    梅澤 麻衣子, 青木 賢治, 長澤 綾子, 佐藤 裕喜, 岡本 竹司, 榛沢 和彦, 名村 理, 土田 正則, 渡邉 佳緒里, 渡辺 玄

    日本血管外科学会雑誌   25 ( Suppl. )   468 - 468   2016.6

     More details

    Language:Japanese   Publisher:(NPO)日本血管外科学会  

    researchmap

  • 反復する気管支粘表皮癌再発に対する4回目の開胸切除例

    北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 171回 )   16 - 16   2016.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • Pneumocephalus and subcutaneous scalp emphysema in a neonate on a low-flow nasal cannula.

    Ai Sugimoto, Masashi Takahashi, Shuichi Shiraishi, Maya Watanabe, Moon Jiyong, Masanori Tsuchida

    General thoracic and cardiovascular surgery   64 ( 5 )   277 - 9   2016.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    A 15-day-old boy after intracardiac repair was discharged from the intensive care unit with a low-flow nasal cannula for oxygen administration. The cannula was a 4-Fr multi-purpose tube with a side hole that was inserted into his left nostril. Next day, he suddenly developed pneumocephalus emerging from the right periorbital swelling and extending to his face and subcutaneous scalp over the next 6 h. A computed tomography (CT) scan revealed massive air pockets in the orbit, subdural space, subcutaneous scalp, and face. The nasal cannula was found to have been inserted deeper than we thought and was thus presumed to be the source of the air pockets. We immediately removed the cannula. Follow-up CTs revealed rapid resolution of the intracranial and subcutaneous air. The subcutaneous emphysema completely disappeared over the next 4 days, and he was discharged without any incident.

    DOI: 10.1007/s11748-014-0454-2

    PubMed

    researchmap

  • A Case of Ectopic ACTH-Producing Pulmonary Carcinoid Arising in an Extralobar Pulmonary Sequestration Reviewed

    Seijiro Sato, Akihiko Kitahara, Terumoto Koike, Takehisa Hashimoto, Riuko Ohashi, Yoichi Kameda, Masanori Tsuchida

    INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY   24 ( 2 )   130 - 134   2016.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SAGE PUBLICATIONS INC  

    Ectopic adrenocorticotrophic hormone (ACTH)-producing bronchopulmonary carcinoid arising in a bronchopulmonary sequestration is extremely rare. The case of a 67-year-old woman with a 1.7-cm nodule in the mediastinal side of the left lower lobe is presented. At 52 years of age, she was diagnosed as having ACTH-dependent Cushing's syndrome (CS). However, no ectopic source of ACTH-secretion was detected. Seven years later, she underwent a bilateral adrenalectomy because of aggravation of her health condition. This time, tumor excision was performed by thoracoscopic surgery. The tumor adhered sparsely to the mediastinal pleura and the left lower lobe and was bluntly separated from these tissues. Pathologically, the tumor was a typical carcinoid arising in an extralobar pulmonary sequestration. Immunohistochemical staining confirmed the secretion of ACTH by bronchopulmonary carcinoid tumor cells. After surgery, the serum ACTH level was almost normalized, and the dexamethasone (1 mg) suppression test showed significant suppression of ACTH.

    DOI: 10.1177/1066896915605615

    Web of Science

    PubMed

    researchmap

  • Lobectomy Versus Segmentectomy in Radiologically Pure Solid Small-Sized Non-Small Cell Lung Cancer Reviewed

    Terumoto Koike, Akihiko Kitahara, Seijiro Sato, Takehisa Hashimoto, Tadashi Aoki, Teruaki Koike, Katsuo Yoshiya, Shin-ichi Toyabe, Masanori Tsuchida

    ANNALS OF THORACIC SURGERY   101 ( 4 )   1354 - 1360   2016.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Background. The indication for limited resection of radiologically pure solid non-small cell lung cancer (NSCLC) is controversial owing to its invasive pathologic characteristics. This study was performed to compare the outcomes after lobectomy and segmentectomy in these NSCLC patients.
    Methods. We retrospectively reviewed 251 patients with radiologically pure solid cT1a NO MO NSCLC who underwent lobectomy or segmentectomy, and the preoperative characteristics of the patients treated with the two operative techniques were matched using propensity score methods. Overall survival (OS) and disease-free survival (DFS) curves were compared using the log rank test, and differences in survival were also evaluated by the McNemar test. The preoperative factors and surgical procedure were analyzed with the multivariate Cox proportional hazards regression model to identify independent predictors of poor OS and DFS.
    Results. In the propensity score matched lobectomy and segmentectomy groups (87 patients per group), the 5-year and 10-year OS rates were 85% versus 84% and 66% versus 63%, respectively; and the 5-year and 10-year DFS rates were 80% versus 77% and 64% versus 58%, respectively. There were no significant differences between the two groups in OS or DFS by the log rank test, and also no significant differences in 3-year, 5-year, or 7-year OS or DFS by the McNemar test. Although age, smoking status, pulmonary function, and carcinoembryonic antigen were identified as significant predictors of both OS and DFS, the surgical procedure was not identified.
    Conclusions. Similar oncologic outcomes after lobectomy and segmentectomy were indicated among patients with radiologically pure solid small-sized NSCLC. (C) 2016 by The Society of Thoracic Surgeons

    DOI: 10.1016/j.athoracsur.2015.10.048

    Web of Science

    researchmap

  • [Endovascular Repair for Acute Phase of Retrograde Type A Aortic Dissection with an Entry in the Descending Aorta].

    Kenji Aoki, Takeshi Okamoto, Hiroki Sato, Osamu Namura, Ryo Onishi, Kazuhiko Hanzawa, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   69 ( 4 )   276 - 81   2016.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Endovascular repair for retrograde type A aortic dissection with an entry in the descending aorta (RAAD) is challenging. We present early and mid- term results of endovascular repair for acute phase of RAAD by using commercially-available device. METHODS: From April 2012 to June 2014, 10 consecutive patients with acute phase of RAAD underwent endovascular repair in our hospital. Of them, 9 patients had emergency surgery within 24 hours after the onset. The other one patient had urgent surgery 3 days after the onset. In all patients, the entry tear was covered with TAG or conformable TAG. RESULTS: Technical success was achieved in all patients. No in-hospital mortality was experienced. In all patients, follow-up computed tomography images showed significant remodeling in the ascending aorta 3 months after surgery. During a median follow-up period of 19.5 months, no patients died and no re-intervention occurred. CONCLUSIONS: In patients with acute phase of RAAD, endovascular repair with commercially-available device can be safely performed and it provides sufficient remodeling in the ascending aorta early after surgery. This technique is an alternative to open repair in these patients.

    PubMed

    researchmap

  • Endovascular Repair for Acute Phase of Retrograde Type A Aortic Dissection with an Entry in the Descending Aorta

    Kenji Aoki, Takeshi Okamoto, Hiroki Sato, Osamu Namura, Ryo Onishi, Kazuhiko Hanzawa, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   69 ( 4 )   276 - 281   2016.4

     More details

    Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Endovascular repair for retrograde type A aortic dissection with an entry in the descending aorta (RAAD) is challenging. We present early and mid- term results of endovascular repair for acute phase of RAAD by using commercially-available device.

    Scopus

    PubMed

    researchmap

  • 気管支形成術を併用して右S6区域切除術をおこなった定型カルチノイドの1例

    橋本 毅久, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   30 ( 3 )   O18 - 5   2016.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • CPFE合併多発肺癌に区域切除と中葉支・B8-10区域枝Double barrel型気管支再建を施行した1例

    佐藤 征二郎, 北原 哲彦, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   30 ( 3 )   V9 - 6   2016.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 気管支管状切除を要した肺癌手術症例の検討

    北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   30 ( 3 )   P27 - 1   2016.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 非小細胞肺癌術後再発例に対する治療成績 遺伝子検索の有用性

    佐藤 征二郎, 北原 哲彦, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   30 ( 3 )   P75 - 7   2016.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 弁輪部膿瘍を伴う大動脈弁位感染性心内膜炎手術症例の特徴

    名村 理, 青木 賢治, 佐藤 裕喜, 岡本 竹司, 長澤 綾子, 榛澤 和彦, 土田 正則

    日本心臓血管外科学会学術総会抄録集   46回   OP5 - 2   2016.2

     More details

    Language:Japanese   Publisher:(NPO)日本心臓血管外科学会  

    researchmap

  • Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model Reviewed

    Hiroyuki Abe, Kenya Kamimura, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Riuko Ohashi, Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   5   e276   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    Liver fibrosis is the final stage of liver diseases that lead to liver failure and cancer. While various diagnostic methods, including the use of serum marker, have been established, no standard therapy has been developed. The objective of this study was to assess the approach of overexpressing matrix metalloproteinase-13 gene (MMP13) in rat liver to prevent liver fibrosis progression. A rat liver fibrosis model was established by ligating the bile duct, followed by liver-targeted hydrodynamic gene delivery of a MMP13 expression vector, containing a CAG promoter-MMP13-IRES-tdTomato-polyA cassette. After 14 days, the serum level of MMP13 peaked at 71.7 pg/ml in MMP13-treated group, whereas the nontreated group only showed a level of similar to 5 pg/ml (P &lt; 0.001). These levels were sustained for the next 60 days. The statistically lower level of the hyaluronic acids in treated group versus the nontreated group (P &lt; 0.05) reveals the therapeutic effect of MMP13 overexpression. Quantitative analysis of tissue stained with sirius red showed a statistically larger volume of fibrotic tissue in the nontreated group compared to that of MMP13-treated rats (P &lt; 0.05). These results suggest that the liver-targeted hydrodynamic delivery of MMP13 gene could be effective in the prevention of liver fibrosis.

    DOI: 10.1038/mtna.2015.49

    Web of Science

    PubMed

    researchmap

  • Surgical Outcomes of Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema and Those with Idiopathic Pulmonary Fibrosis without Emphysema Reviewed

    Seijiro Sato, Terumoto Koike, Takehisa Hashimoto, Hiroyuki Ishikawa, Akira Okada, Takehiro Watanabe, Masanori Tsuchida

    ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY   22 ( 4 )   216 - 223   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MEDICAL TRIBUNE INC  

    Objectives: Combined pulmonary fibrosis and emphysema (CPFE) is a unique disorder. The aim of this study was to compare the surgical outcomes of lung cancer patients with CPFE and those with idiopathic pulmonary fibrosis (IPF) without emphysema.
    Methods: A total of 1548 patients who underwent surgery for primary lung cancer between January 2001 and December 2012 were retrospectively reviewed.
    Results: Of the 1548 patients, 55 (3.6%) had CPFE on computed tomography (CT), and 45 (2.9%) had IPF without emphysema. The overall and disease-free 5-year survival rates for patients with CPFE were not significantly worse than those for patients with IPF without emphysema (24.9% vs. 36.8%, p = 0.814; 39.8% vs. 39.3%, p = 0.653, respectively). Overall, 21 (38.1%) patients with CPFE and nine patients (20.0%) with IPF without emphysema developed postoperative cardiopulmonary complications. Patients with CPFE had significantly more postoperative cardiopulmonary complications involving pulmonary air leakage for &gt; 6 days, hypoxemia, and arrhythmia than patients with IPF without emphysema (p = 0.048).
    Conclusions: There was no significant difference in survival after surgical treatment between CPFE patients and IPF patients without emphysema, but CPFE patients had significantly higher morbidity than IPF patients without emphysema.

    DOI: 10.5761/atcs.oa.15-00315

    Web of Science

    researchmap

  • Resection of a large ectopic parathyroid adenoma: A case report. Reviewed International journal

    Sato S, Kitahara A, Koike T, Hashimoto T, Ohashi R, Motoi N, Tsuchida M

    International journal of surgery case reports   23   8 - 11   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Parathyroid adenomas are the most common cause of primary hyperparathyroidism. However, cases of parathyroid adenomas greater than 4cm with osteitis fibrosa cystica are extremely rare. Herein, we report a case of resection of a large ectopic mediastinal parathyroid adenoma. CASE PRESENTATIONS: A 46-year-old female with chief complaints of bone pain and gait disturbance was referred to our hospital. Physical examination revealed many mobile teeth in her oral cavity, distortion of the vertebral body, and bowlegs. Laboratory tests showed hypercalcemia, hypophosphatemia, and elevated serum levels of intact parathyroid hormone. Chest CT revealed a 42-mm well-defined, enhancing mass in front of the left-sided tracheal bifurcation. Her findings were diagnosed as primary hyperparathyroidism due to an ectopic mediastinal parathyroid tumor. We performed a median sternotomy and resected the tumor. The tumor was a solid, yellowish-brown mass measuring 42×42 mm. Pathologically, the tumor consisted mainly of chief cells with some oxyphil cells; there were no necrotic areas or nuclear atypia, and few mitotic figures. We diagnosed the tumor as an ectopic mediastinal parathyroid adenoma. Eight months after the resection, her serum calcium, phosphorus, and intact PTH levels were normal. DISCUSSION AND CONCLUSIONS: Parathyroid adenomas and parathyroid carcinomas have disparate natural histories, but they can be difficult to differentiate on the basis of preoperative clinical characteristics. We believe that long-term follow-up of these cases is required because there have been few reports on the postoperative natural history of large parathyroid adenomas.

    DOI: 10.1016/j.ijscr.2016.04.007

    Web of Science

    PubMed

    researchmap

  • 蛋白漏出性胃腸症を呈した開心術後収縮性心膜炎の1手術例

    名村 理, 岡本 竹司, 長澤 綾子, 佐藤 裕喜, 青木 賢治, 榛澤 和彦, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 169回 )   38 - 38   2015.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 肺癌術後に発症した慢性出血性膿胸の1例

    梅澤 麻以子, 佐藤 征二郎, 北原 哲彦, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 169回 )   28 - 28   2015.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • ステントグラフト合併症に対する治療 大動脈解離に対して施行したTEVARの追加治療

    岡本 竹司, 横井 良彦, 長澤 綾子, 佐藤 裕喜, 青木 賢治, 榛澤 和彦, 名村 理, 土田 正則

    人工臓器   44 ( 2 )   S - 63   2015.10

     More details

    Language:Japanese   Publisher:(一社)日本人工臓器学会  

    researchmap

  • 合併症を有する肺癌に対する外科的治療戦略 高齢者肺癌の外科治療戦略 高齢者総合機能評価の必要性

    佐治 久, 中村 廣繁, 土田 正則, 奥村 典仁, 園部 誠, 青景 圭樹, 中尾 将之, 宮崎 拓郎, 春木 朋広

    肺癌   55 ( 5 )   358 - 358   2015.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 非小細胞肺癌pN1症例における外科治療成績

    佐藤 征二郎, 北原 哲彦, 小池 輝元, 橋本 毅久, 土田 正則

    肺癌   55 ( 5 )   482 - 482   2015.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 病理病期I-III期肺腺癌患者における至適術後経過観察法の検討

    小池 輝元, 北原 哲彦, 佐藤 征二郎, 土田 正則

    肺癌   55 ( 5 )   494 - 494   2015.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 肺扁平上皮癌におけるCEA、SCC測定の意義

    北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    肺癌   55 ( 5 )   708 - 708   2015.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 大腸癌術後の転移性肺腫瘍切除断端に発生した原発性肺扁平上皮癌の1例

    佐藤 征二郎, 北原 哲彦, 小池 輝元, 土田 正則

    肺癌   55 ( 4 )   298 - 298   2015.8

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 術前に胸壁腫瘍が疑われた肺葉外肺分画症の1切除例

    北原 哲彦, 佐藤 征二郎, 梅澤 麻以子, 小池 輝元, 橋本 毅久, 土田 正則

    気管支学   37 ( 4 )   480 - 480   2015.7

  • Brevibacterium luteolumによる弁輪部膿瘍を伴う大動脈弁位感染性心内膜炎の1例

    志賀 優, 名村 理, 佐藤 裕喜, 岡本 竹司, 青木 賢治, 長澤 綾子, 榛澤 和彦, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 168回 )   29 - 29   2015.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 内腸骨動脈瘤合併肺癌に対し肺切除・ステントグラフト内挿術を一期的に施行した1例

    梅澤 麻以子, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 168回 )   27 - 27   2015.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 外腸骨静脈に発生した平滑筋肉腫の1切除例

    佐藤 哲彰, 名村 理, 岡本 竹司, 大西 遼, 佐藤 裕喜, 青木 賢治, 榛澤 和彦, 土田 正則

    日本血管外科学会雑誌   24 ( 3 )   622 - 622   2015.5

     More details

    Language:Japanese   Publisher:(NPO)日本血管外科学会  

    researchmap

  • Effect of Fibrotic Tissue on Liver-Targeted Hydrodynamic Gene Delivery Reviewed

    Kobayashi Yuji, Kamimura Kenya, Abe Hiroyuki, Ohtsuka Masato, Miura Hiromi, Yokoo Takeshi, Kanefuji Tsutomu, Suda Takeshi, Zhang Guisheng, Tsuchida Masanori, Aoyagi Yutaka, Liu Dexi, Terai Shuji

    MOLECULAR THERAPY   23   S141   2015.5

  • Effective Prevention of Liver Fibrosis by Liver-Targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in Rat Liver Fibrosis Model Reviewed

    Hiroyuki Abe, Kenya Kamimura, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Riuko Ohashi, Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY   23   S234 - S234   2015.5

     More details

    Language:English   Publisher:NATURE PUBLISHING GROUP  

    DOI: 10.1016/S1525-0016(16)34197-1

    Web of Science

    researchmap

  • [Simultaneous pulmonary resection and endovascular repair for patients with coexisting primary lung cancer and aneurysm].

    Terumoto Koike, Hiroki Sato, Seijiro Sato, Takeshi Okamoto, Takehisa Hashimoto, Kazuhiko Hanzawa, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   68 ( 4 )   293 - 7   2015.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    The surgical strategy for coexisting lung cancer and aneurysm is controversial owing to the risk of aneurysm rupture during the perioperative period of pulmonary resection. We performed simultaneous pulmonary resection and endovascular repair in 2 patients with coexisting lung cancer and aneurysm. Case 1:A 74-year-old man presented at our hospital with cT2aN0M0 lung cancer and a 5.0 cm abdominal aortic aneurysm. Because computed tomography indicated the possibility of advanced lung cancer, we decided to perform simultaneous surgery for lung cancer and the aneurysm. Under general anesthesia, endovascular aneurysm repair was performed before right lower lobectomy with lymphadenectomy. The postoperative course was uneventful, and the patient was discharged on postoperative day 12. Case 2:A 72-year-old man presented at our hospital with cT2aN1M0 lung cancer, a 5.0 cm left internal iliac artery aneurysm, and right renal cell carcinoma( RCC). Because the lung cancer was advanced and the patients needed following surgical treatment for RCC, we decided to perform simultaneous surgery for lung cancer and the aneurysm. Under general anesthesia, endovascular aneurysm repair was performed before right upper lobectomy with lymphadenectomy. The postoperative course was uneventful, and the patient was discharged on postoperative day 11.

    PubMed

    researchmap

  • 心臓血管 持続グルコースモニタを用いた心臓手術中の血糖変動に関する検討

    佐藤 裕喜, 石川 友美, 細島 康宏, 青木 賢治, 岡本 竹司, 名村 理, 榛澤 和彦, 土田 正則

    日本外科学会定期学術集会抄録集   115回   OP - 6   2015.4

     More details

    Language:Japanese   Publisher:(一社)日本外科学会  

    researchmap

  • 右下葉気管支管状切除・気管支形成術

    橋本 毅久, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   29 ( 3 )   V2 - 3   2015.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • pN2 III期非小細胞肺癌における縦隔リンパ節転移様式による病期細分化の検討

    佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則

    日本呼吸器外科学会雑誌   29 ( 3 )   O35 - 3   2015.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 触知困難小型肺癌病変に対するVirtual-assisted Lung Mappingを用いた胸腔鏡補助下肺区域切除の初期経験

    小池 輝元, 佐藤 征二郎, 橋本 毅久, 佐藤 雅昭, 土田 正則

    日本呼吸器外科学会雑誌   29 ( 3 )   O16 - 6   2015.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 呼吸器 間質性肺炎合併肺癌に対する再手術の意義

    佐藤 征二郎, 小池 輝元, 橋本 毅久, 北原 哲彦, 渡辺 健寛, 土田 正則

    日本外科学会定期学術集会抄録集   115回   PLS - 1   2015.4

     More details

    Language:Japanese   Publisher:(一社)日本外科学会  

    researchmap

  • Time-resolved CT angiographyが診断に有用であった上行大動脈置換術後大動脈基部破裂の手術例

    大西 遼, 青木 賢治, 名村 理, 佐藤 裕喜, 岡本 竹司, 榛澤 和彦, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 167回 )   11 - 11   2015.3

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 診断に苦慮した縦隔内異所性副甲状腺腫の1切除例

    佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 167回 )   29 - 29   2015.3

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 【呼吸器外科の手術看護パーフェクトマニュアル】(第2章)実践編 術式別の術中看護マニュアル 肺癌に対する肺楔状切除術

    橋本 毅久, 土田 正則

    オペナーシング   ( 2015臨時増刊 呼吸器外科の手術看護パーフェクトマニュアル )   111 - 117   2015.3

     More details

    Language:Japanese   Publisher:(株)メディカ出版  

    researchmap

  • A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma Reviewed

    Motohiko Yamazaki, Hiroyuki Ishikawa, Ryosuke kunii, Akiko Tasaki, Suguru Sato, Yohei Ikeda, Norihiko Yoshimura, Takehisa Hashimoto, Masanori Tsuchida, Hidefumi Aoyama

    EUROPEAN JOURNAL OF RADIOLOGY   84 ( 1 )   178 - 184   2015.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    Objectives: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma.
    Methods: This retrospective study included 250 consecutive patients who underwent complete resection for &lt;= 3-cm pathological stage I (T1-2aNOMO) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC).
    Results: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P &lt; 0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC = 0.853 versus 0.792; P = 0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were &gt;= 48% and &gt;= 3.7 ng/mL, respectively.
    Conclusion: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.cjrad.2014.10.009

    Web of Science

    researchmap

  • Posterior TGA型両大血管右室起始症に対する動脈スイッチ術(Jatene原法)と心室内血流路作成の1例

    白石 修一, 高橋 昌, 渡邉 マヤ, 杉本 愛, 土田 正則

    日本心臓血管外科学会雑誌   44 ( 1 )   21 - 24   2015.1

     More details

    Language:Japanese   Publisher:(NPO)日本心臓血管外科学会  

    症例は男児。在胎38週3日、体重2,880gで仮死なく出生し、生直後より高度のチアノーゼを認め心エコー検査にて両大血管右室起始(DORV)と診断され同日当院NICUへ緊急搬送された。大血管関係は大動脈がやや右後方、肺動脈がやや左前方であり、心室中隔欠損は肺動脈弁下に存在するposterior TGA型DORVであった。漏斗部中隔は三尖弁側の心室漏斗部皺襞(VIF)側に挿入し、心室中隔にほぼ整列していた。手術は日齢25に胸骨正中切開・体外循環下に行った。心停止下に三尖弁経由に心室中隔欠損(secondary IVF)を閉鎖(心室内血流路作成)し、次に動脈スイッチ手術を行った。冠動脈パターンは1R2LCXのShaher 9型であり、trap-door法を用いた冠動脈移植を行った。肺動脈再建は前方転位を行わないJatene原法を行った。術後血行動態は早期から安定し、術後2日に人工呼吸器離脱、術後19日に退院した。(著者抄録)

    researchmap

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J01122&link_issn=&doc_id=20150128260005&doc_link_id=10.4326%2Fjjcvs.44.21&url=https%3A%2F%2Fdoi.org%2F10.4326%2Fjjcvs.44.21&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • Surgical resection for a second primary lung cancer originating close to the initial surgical margin for lung squamous cell carcinoma. International journal

    Seijiro Sato, Terumoto Koike, Takehisa Hashimoto, Masanori Tsuchida

    Case reports in surgery   2015   462193 - 462193   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Few reports have described surgical resection for second primary lung cancers originating close to the initial surgical margin for lung cancer. A 64-year-old man had undergone left segmentectomy with lymph node dissection for small peripheral squamous cell lung cancer using video-assisted thoracic surgery, with pathology confirming a small tumor 12 mm in diameter identified about 3 cm from the surgical margin. Eighteen months after initial surgery, computed tomography revealed a 30 mm pulmonary nodule close to the initial surgical margin in the residual left upper lobe and the serum level of carcinoembryonic antigen was found to be increased. Local recurrence on the staple-line of the surgical margin was suspected, and completion left upper lobectomy was performed. Histological examination identified not only a squamous cell carcinoma component but also a small cell carcinoma component. The immunohistochemical staining pattern of the second tumor differed from that of the initial resected lung squamous cell carcinoma. The final pathological diagnosis was a second primary tumor with mixed small cell carcinoma and squamous cell carcinoma histology.

    DOI: 10.1155/2015/462193

    PubMed

    researchmap

  • Foregut cystに発生した異所性ACTH産生カルチノイドの1例

    佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則, 大橋 瑠子, 梅津 哉

    肺癌   54 ( 7 )   1003 - 1003   2014.12

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • IEに対するAVR後6年目に発症したMicrococcus roseusによるPVEの1手術例

    大西 遼, 名村 理, 佐藤 哲彰, 佐藤 裕喜, 岡本 竹司, 青木 賢治, 榛澤 和彦, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 166回 )   16 - 16   2014.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • [Detection of the communication site by dye injection method at the surgery for pleuroperitoneal communication].

    Seijiro Sato, Terumoto Koike, Takehisa Hashimoto, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   67 ( 11 )   967 - 70   2014.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    A 65-year-old male with end stage renal failure due to IgA nephritis commenced continuous ambulatory peritoneal dialysis (CAPD). Three weeks after initiation of CAPD, right hydrothorax developed. Then, we strongly assumed pleuroperitoneal communication( PPC) although the pleural effusion did not show high concentration of glucose. He underwent thoracoscopic surgery for PPC. On the inner, central tendons part of the diaphragm, there were a few blebs. One hour after 3 l of peritoneal dialysis solution containing 15 ml indigocarmine was instilled into the abdomen through a CAPD catheter, the blebs were tense and colored blue by the dye solution. The blebs were directly sutured and diaphragm was covered by polyglycolic acid sheet and fibrin glue all over. Since then, he resumed CAPD, without recurrence of hydrothorax. Then we investigated the treatment outcome of video-assisted thoracic surgery (VATS) for PPC in Japan. The outcome was poorer in cases in which communication was not detected intraoperatively. These patients should be given sufficient consideration for surgical procedure.

    PubMed

    researchmap

  • 間質性肺炎合併肺癌切除後再手術の経験

    土田 正則, 橋本 毅久, 小池 輝元, 佐藤 征二郎

    肺癌   54 ( 5 )   568 - 568   2014.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • V-V ECMO使用下胸骨正中切開アプローチにて切除した気管原発MALTリンパ腫の1例

    小池 輝元, 佐藤 征二郎, 橋本 毅久, 土田 正則

    肺癌   54 ( 5 )   380 - 380   2014.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 巨大な胸壁腫瘍が主体の胸壁浸潤肺癌に対し、高位後側方切開(後方アプローチ)にて切除した1例

    佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則

    肺癌   54 ( 5 )   373 - 373   2014.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 慢性血液透析患者に対する肺癌手術周術期及び長期予後の検討

    佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則

    肺癌   54 ( 5 )   683 - 683   2014.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 両側肺動脈絞扼術後に根治手術(大動脈弓再建+動脈スイッチ手術+心室内血流路作成)を施行した両大血管右室起始・大動脈弓離断症の1例

    白石 修一, 高橋 昌, 渡邉 マヤ, 杉本 愛, 土田 正則

    日本心臓血管外科学会雑誌   43 ( 5 )   265 - 269   2014.9

     More details

    Language:Japanese   Publisher:(NPO)日本心臓血管外科学会  

    症例は男児。在胎40週0日、体重3,465gで仮死なく出生した。生直後より高度のチアノーゼを認め心エコー検査にて両大血管右室起始・大動脈弓離断症と診断された。同日よりプロスタグランディン製剤の持続静注が開始され、当院NICUへ緊急搬送された。高肺血流に伴う急性心不全状態であったため、4生日に両側肺動脈絞扼術を施行した。術後に利尿が得られ全身状態は改善したが心不全状態が継続したため、9生日時に根治手術を行った。胸骨再正中切開下に上下半身分離体外循環を確立し、三尖弁経由にVSDから心室内血流路を作成し、次にtrap door法を用いて冠動脈移植を行った。Lecompte maneuverの後に大動脈弓再建(直接吻合)を行った。さらに右室流出路をパッチで拡大し、大動脈遮断解除後に肺動脈再建を行った。人工心肺離脱はとくに問題なく、開胸状態で手術を終了し4病日に閉胸し14病日に人工呼吸器を離脱した。術後に肺炎・乳び胸などを合併したが内科的治療にて改善し、78病日に退院した。(著者抄録)

    researchmap

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01122&link_issn=&doc_id=20140924140004&doc_link_id=10.4326%2Fjjcvs.43.265&url=https%3A%2F%2Fdoi.org%2F10.4326%2Fjjcvs.43.265&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • Fontan operation in a paediatric patient with a history of Takotsubo cardiomyopathy. International journal

    Maya Watanabe, Shuichi Shiraishi, Masashi Takahashi, Masanori Tsuchida

    Interactive cardiovascular and thoracic surgery   19 ( 2 )   326 - 8   2014.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Takotsubo cardiomyopathy is very rare in the paediatric population and has not been described in a single-ventricle patient yet. We report the case of a 4-year old boy with a history of Takotsubo cardiomyopathy in whom we performed a Fontan operation. After coil embolization of the minor aortopulmonary collateral arteries, the patient developed Takotsubo cardiomyopathy. His cardiac function largely recovered over 3 months. He subsequently progressed to a Fontan operation and was weaned uneventfully off cardiopulmonary bypass, on minimal doses of dopamine and milrinone; he was sedated using a dexmedetomidine infusion and a midazolam bolus. There were no signs of recurrent Takotsubo cardiomyopathy over the subsequent 2 years.

    DOI: 10.1093/icvts/ivu108

    PubMed

    researchmap

  • [Adult endocardial blood cyst; report of a case]

    Yuka Okubo, Kenji Aoki, Osamu Namura, Takeshi Okamoto, Kazuhiko Hanzawa, Hisanaga Moro, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   67 ( 7 )   571 - 574   2014.7

     More details

    Publishing type:Research paper (scientific journal)  

    We report herein a rare case of endocardial blood cyst (EBC) in an adult patient. A 63-year-old asymptomatic woman underwent echocardiography, which incidentally detected a cardiac tumor in the right atrium. On echocardiography, the tumor was revealed to be a 30-mm round mass with thin, hyperechogenic walls and heterogeneously hypoechogenic contents. The lesion was attached to the septum. On computed tomography, the tumor appeared partly calcified and showed poor contrast-enhancement. On magnetic resonance imaging, the lesion appeared isointense or slightly hyperintense in T1 and T2-weighted sequences. Myxoma was strongly suspected based on these preoperative imaging findings. The tumor was successfully excised under cardiopulmonary bypass. Gross examination confirmed that the cyst was filled with blood. The cystic walls comprised thin-layered fibrous tissue lined with endocardial cells. No tumor cells were found. The diagnosis of EBC was confirmed based on histopathological examination, and the postoperative course was uneventful.

    Scopus

    PubMed

    researchmap

  • [Adult endocardial blood cyst; report of a case].

    Yuka Okubo, Kenji Aoki, Osamu Namura, Takeshi Okamoto, Kazuhiko Hanzawa, Hisanaga Moro, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   67 ( 7 )   571 - 4   2014.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    We report herein a rare case of endocardial blood cyst (EBC) in an adult patient. A 63-year-old asymptomatic woman underwent echocardiography, which incidentally detected a cardiac tumor in the right atrium. On echocardiography, the tumor was revealed to be a 30-mm round mass with thin, hyperechogenic walls and heterogeneously hypoechogenic contents. The lesion was attached to the septum. On computed tomography, the tumor appeared partly calcified and showed poor contrast-enhancement. On magnetic resonance imaging, the lesion appeared isointense or slightly hyperintense in T1 and T2-weighted sequences. Myxoma was strongly suspected based on these preoperative imaging findings. The tumor was successfully excised under cardiopulmonary bypass. Gross examination confirmed that the cyst was filled with blood. The cystic walls comprised thin-layered fibrous tissue lined with endocardial cells. No tumor cells were found. The diagnosis of EBC was confirmed based on histopathological examination, and the postoperative course was uneventful.

    PubMed

    researchmap

  • 胸壁浸潤病変が腫瘍の主体であった肺扁平上皮癌の一例

    佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 165回 )   27 - 27   2014.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 区域切除後の断端近傍に発生した異時多発肺癌の1切除例

    佐藤 征二郎, 白戸 亨, 小池 輝元, 橋本 毅久, 土田 正則

    肺癌   54 ( 3 )   166 - 166   2014.6

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • MDCTが有用であった大動脈基部置換術後仮性動脈瘤に対する再手術の2症例

    名村 理, 岡本 竹司, 青木 賢治, 佐藤 裕喜, 榛澤 和彦, 土田 正則

    日本血管外科学会雑誌   23 ( 2 )   507 - 507   2014.4

     More details

    Language:Japanese   Publisher:(NPO)日本血管外科学会  

    researchmap

  • 若年性肺気腫に伴う巨大ブラを切除し著明な呼吸機能改善を得た1例

    小池 輝元, 白戸 亨, 佐藤 征二郎, 橋本 毅久, 土田 正則

    日本呼吸器外科学会雑誌   28 ( 3 )   1 - 8   2014.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 肺扁平上皮癌における幹細胞関連マーカー発現の検討

    佐藤 征二郎, 白戸 亨, 小池 輝元, 橋本 毅久, 土田 正則

    日本呼吸器外科学会雑誌   28 ( 3 )   O16 - 4   2014.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 嚢胞内吸引療法により人工呼吸器を離脱し手術することができた巨大気腫性肺嚢胞の1例

    橋本 毅久, 白戸 亨, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   28 ( 3 )   RV4 - 2   2014.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • Kommerell憩室に対するTEVARの経験

    岡本 竹司, 横井 良彦, 佐藤 裕喜, 青木 賢治, 名村 理, 榛澤 和彦, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 164回 )   15 - 15   2014.3

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 胸膜浸潤におけるupstagingの妥当性について

    佐藤 征二郎, 白戸 亨, 小池 輝元, 橋本 毅久, 土田 正則

    日本外科学会雑誌   115 ( 臨増2 )   645 - 645   2014.3

     More details

    Language:Japanese   Publisher:(一社)日本外科学会  

    researchmap

  • 化学療法後に完全切除した混合型胚細胞腫瘍の小児切除例

    土田 正則, 白戸 亨, 佐藤 征二郎, 小池 輝元, 橋本 毅久

    日本胸部外科学会関東甲信越地方会要旨集   ( 164回 )   27 - 27   2014.3

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 左側心臓弁術後の高度三尖弁閉鎖不全症再手術の問題点

    名村 理, 青木 賢治, 岡本 竹司, 上原 彰史, 佐藤 裕喜, 榛澤 和彦, 土田 正則

    日本心臓血管外科学会雑誌   43 ( Suppl. )   395 - 395   2014.1

     More details

    Language:Japanese   Publisher:(NPO)日本心臓血管外科学会  

    researchmap

  • 小型非小細胞肺癌に対する標準手術としての根治縮小手術の妥当性に関する研究

    小池 輝元, 佐藤 征二郎, 橋本 毅久, 土田 正則

    新潟県医師会報   ( 766 )   8 - 9   2014.1

     More details

    Language:Japanese   Publisher:新潟県医師会  

    researchmap

  • 2.血痰による無気肺にて呼吸不全に陥り人工呼吸管理を要した原発性気管支動脈蔓状血管腫の1例(第58回 日本呼吸器内視鏡学会北陸支部会)

    佐藤 美由紀, 野嵜 幸一郎, 朝川 勝明, 三浦 理, 茂呂 寛, 各務 博, 成田 一衛, 鈴木 榮一, 佐藤 征二郎, 小池 輝元, 土田 正則, 高野 徹

    気管支学   36 ( 4 )   441 - 441   2014

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器内視鏡学会  

    DOI: 10.18907/jjsre.36.4_441_2

    CiNii Article

    researchmap

  • A Case of Long-term Survival with Primary Pericardial Mesothelioma Treated by Pemetrexed and Platinum-based Chemotherapy Reviewed

    Tomohiro Tanaka, Yu Saida, Satoshi Shoji, Koichiro Nozaki, Natsue Igarashi, KO Sato, Masaaki Okajima, Satoru Miura, Junta Tanaka, Nobumasa Aoki, Toshiyuki Koya, Hiroshi Kagamu, Ichiei Narita, Satoshi Watanabe, Hirohisa Yoshizawa, HIrohiko Shinohara, Masanori Tsuchida, Takashi Shimizu

    Niigata Medical Journal   127 ( 12 )   689 - 696   2013.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Niigata Medical Society  

    CiNii Article

    CiNii Books

    researchmap

    Other Link: http://hdl.handle.net/10191/36221

  • 左巨大ブラを有する再発気胸に対する1手術例

    白戸 亨, 佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 163回 )   15 - 15   2013.11

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 小型肺癌に対する縮小手術の長期予後 CT上充実陰影を呈する小型非小細胞肺癌に対する肺葉切除と区域切除の長期予後比較

    小池 輝元, 白戸 亨, 佐藤 征二郎, 橋本 毅久, 篠原 博彦, 青木 正, 小池 輝明, 吉谷 克雄, 土田 正則

    肺癌   53 ( 5 )   380 - 380   2013.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 胸腺腫術後再発症例に対する治療経験

    佐藤 征二郎, 白戸 亨, 小池 輝元, 橋本 毅久, 土田 正則

    肺癌   53 ( 5 )   494 - 494   2013.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 左肺上葉切除から12年後に同側再々手術として残存肺全摘術を施行した1例

    白戸 亨, 佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則

    肺癌   53 ( 5 )   675 - 675   2013.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • A CASE OF THYMMA WITH ANTI-GAD ANTIBODY POSITIVE MYASTHENIA GRAVIS

    SATO Seijiro, TSUCHIDA Masanori

    The journal of the Japanese Practical Surgeon Society   74 ( 8 )   2101 - 2105   2013.8

     More details

    Language:Japanese   Publisher:Japan Surgical Association  

    A 75-year-old man visited a neighboring hospital because of eyelid ptosis, double vision, and feeling of something wrong around the mouth was found to be anti-acetylcholine receptor (anti-AchR) antibody positive and Tensilon test positive. Chest CT scan showed a 56 × 30 mm tumor at the anterior mediastinum. Thymoma associated with myasthenia gravis was thus diagnosed. In addition, close examinations for an increased blood sugar level in a short time showed strong positivity for serum anti-glutamic acid decarboxylase (anti-GAD) antibody, 5,100 u/ml, for that the patient was considered also to have type 1 diabetes mellitus. Extended thymectomy was performed for the thymoma associated with myasthenia gravis that was clarified to be in Masaoka's stage III invading the left brachiocephalic vein. The histopathological diagnosis was type B1 thymoma. It was GAD antibody positive on immunohistochemical stainigs. Postoperative introduction of steroids resulted in disappearance of myasthenia gravis and decreasing tendencies in both anti-AchR antibodies and anti-GAD antibodies, however, no improvement in diabetes mellitus has been confirmed.<BR>Although thymomas are often associated with a variety of autoimmune disorders including myasthenia gravis, those associated with type 1 diabetes mellitus, the representative autoimmune disease, are rare. This paper deals with our case of thymoma with anti-GAD antibody positive myasthenia gravis, together with previous cases reported in Japan so far.

    DOI: 10.3919/jjsa.74.2101

    CiNii Article

    CiNii Books

    researchmap

    Other Link: http://search.jamas.or.jp/link/ui/2014115092

  • Risk factor analysis of locoregional recurrence after sublobar resection in patients with clinical stage IA non-small cell lung cancer.

    Koike Terumoto, Koike Teruaki, Yoshiya Katsuo, Tsuchida Masanori, Toyabe Shin-ichi

    J Thorac Cardiovasc Surg   146 ( 2 )   372 - 378   2013.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Although lobectomy is the standard surgical procedure for operable non-small cell lung cancer (NSCLC), sublobar resection also has been undertaken for various reasons. The aim of this study was to identify risk factors of locoregional recurrence and poor disease-specific survival in patients with clinical stage IA NSCLC undergoing sublobar resection. METHODS: We retrospectively reviewed 328 patients with clinical stage IA NSCLC who underwent segmentectomy or wedge resection. Demographic, clinical, and pathologic factors were analyzed using the log-rank test as univariate analyses, and all factors were entered into a Cox proportional hazards regression model for multivariate analyses to identify independent predictors of locoregional recurrence and poor disease-specific survival. RESULTS: The 5- and 10-year locoregional recurrence-free probabilities were 84.8% and 83.6%, respectively, and the 5- and 10-year disease-specific survivals were 83.6% and 73.6%, respectively. Four independent predictors of locoregional recurrence were identified: wedge resection (hazard ratio [HR], 5.787), microscopic positive surgical margin (HR, 3.888), visceral pleural invasion (HR, 2.272),

    DOI: 10.1016/j.jtcvs.2013.02.057

    PubMed

    researchmap

  • Risk factor analysis of locoregional recurrence after sublobar resection in patients with clinical stage IA non-small cell lung cancer Reviewed

    Terumoto Koike, Teruaki Koike, Katsuo Yoshiya, Masanori Tsuchida, Shin-ichi Toyabe

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   146 ( 2 )   372 - 378   2013.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MOSBY-ELSEVIER  

    Objective: Although lobectomy is the standard surgical procedure for operable non-small cell lung cancer (NSCLC), sublobar resection also has been undertaken for various reasons. The aim of this study was to identify risk factors of locoregional recurrence and poor disease-specific survival in patients with clinical stage IA NSCLC undergoing sublobar resection.
    Methods: We retrospectively reviewed 328 patients with clinical stage IA NSCLC who underwent segmentectomy or wedge resection. Demographic, clinical, and pathologic factors were analyzed using the log-rank test as univariate analyses, and all factors were entered into a Cox proportional hazards regression model for multivariate analyses to identify independent predictors of locoregional recurrence and poor disease-specific survival.
    Results: The 5- and 10-year locoregional recurrence-free probabilities were 84.8% and 83.6%, respectively, and the 5- and 10-year disease-specific survivals were 83.6% and 73.6%, respectively. Four independent predictors of locoregional recurrence were identified: wedge resection (hazard ratio [HR], 5.787), microscopic positive surgical margin (HR, 3.888), visceral pleural invasion (HR, 2.272), and lymphatic permeation (HR, 3.824). Independent predictors of poor disease-specific survival were identified as follows: smoking status (Brinkman Index; HR, 1.001), wedge resection (HR, 3.183), microscopic positive surgical margin (HR, 3.211), visceral pleural invasion (HR, 2.553), and lymphatic permeation (HR, 3.223). All 4 predictors of locoregional recurrence also were identified as independent predictors of poor disease-specific survival.
    Conclusions: Segmentectomy should be the surgical procedure of first choice in patients with clinical stage IA NSCLC who are being considered for sublobar resection. Patients having tumors presenting with no suspicious of pleural involvement would be suitable candidates for sublobar resection.

    DOI: 10.1016/j.jtcvs.2013.02.057

    Web of Science

    researchmap

  • 間質性肺炎合併肺癌の術後急性増悪予測因子としての肺動脈圧評価

    小池 輝元, 湯山 聡子, 佐藤 征二郎, 橋本 毅久, 土田 正則

    日本呼吸器外科学会雑誌   27 ( 5 )   562 - 568   2013.7

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    間質性肺炎(IP)合併肺癌手術例における肺動脈圧評価による術後IP急性増悪予測の可能性につき検討した。2001-12年に術前画像上IPを認めた肺癌切除例53例を対象とし、CT上肺動脈径(PA径)、肺動脈径/大動脈径比(PA/Ao比)、また、術前心エコーを行った14例では、推定肺動脈圧による肺動脈圧評価を行った。術後急性増悪を認めたAE(+)群5例と、認めなかったAE(-)群48例に分けて比較検討した。術前CT上PA径、PA/Ao比は2群間で差を認めなかったが、IPなしの対照症例と比較しPA径、PA/Ao比ともIP合併例で有意に高値であり、また、急性増悪後のPA径の拡大、PA/Ao比の増加が示された。心エコーによる推定肺動脈圧はAE(+)群で有意に高値であった。IP合併肺癌におけるCT上PA径、PA/Ao比の継時的変化の評価、心エコーでの肺動脈圧評価による術後急性増悪予測の可能性が示された。(著者抄録)

    researchmap

    Other Link: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J02256&link_issn=&doc_id=20130723260005&doc_link_id=10.2995%2Fjacsurg.27.562&url=https%3A%2F%2Fdoi.org%2F10.2995%2Fjacsurg.27.562&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 脈管浸潤(VI)とリンパ管浸潤(Ly)の組織分類別検討

    佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則

    日本呼吸器外科学会雑誌   27 ( 3 )   P07 - 04   2013.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 虚血性心疾患・心房細動合併肺癌患者の周術期管理と合併症

    橋本 毅久, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   27 ( 3 )   P68 - 10   2013.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 充実陰影を呈する肺野末梢cT1aN0M0非小細胞肺癌に対する外科治療成績

    小池 輝元, 佐藤 征二郎, 橋本 毅久, 白戸 亨, 篠原 博彦, 吉谷 克雄, 小池 輝明, 鳥谷部 真一, 土田 正則

    日本外科学会雑誌   114 ( 臨増2 )   555 - 555   2013.3

     More details

    Language:Japanese   Publisher:(一社)日本外科学会  

    researchmap

  • Surgical repair of aortico-left ventricular tunnel: report of two cases. International journal

    Shuichi Shiraishi, Masashi Takahashi, Maya Watanabe, Masanori Tsuchida

    Asian cardiovascular & thoracic annals   21 ( 1 )   67 - 70   2013.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Two girls aged 1 and 15 years with heart murmurs were diagnosed with aortico-left ventricular tunnel. In the 1-year-old, the tunnel had an intracardiac aneurysm within the right ventricular outflow tract; both openings were closed The 15-year-old had no aneurysmal dilatation, but she had mild aortic regurgitation; the aortic opening of the tunnel was closed with a patch. Both girls had uneventful postoperative courses with excellent early results.

    DOI: 10.1177/0218492312443529

    PubMed

    researchmap

  • Neuroprotection following mild hypothermia after spinal cord ischemia in rats Reviewed

    Takeshi Saito, Shino Saito, Hiroshi Yamamoto, Masanori Tsuchida

    JOURNAL OF VASCULAR SURGERY   57 ( 1 )   173 - 181   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MOSBY-ELSEVIER  

    Objective: We examined the hypothesis that a 1 C reduction in body temperature would reduce gray and white matter injury induced by spinal cord ischemia in rats. In addition, we evaluated the relationship between reactive astrogliosis and gray or white matter injury after spinal cord ischemia with a 1 C reduction in body temperature or normothermia.
    Methods: Rats were randomly divided into hypothermia (1 C decrease in body temperature to 36.3 degrees C), normothermia (37.3 degrees C), and sham surgery groups (n = 6/group). Hypothermia was induced 15 minutes before ischemia and maintained during ischemia. Animals were then rewarmed to normothermia. Spinal cord ischemia was induced by a balloon catheter in the thoracic aorta, and the proximal mean arterial blood pressure was maintained at 40 mm Hg for 14 minutes. Hind limb motor function was assessed at 2, 7, 14, 21, and 28 days after reperfusion. At 28 days after reperfusion, gray matter damage was assessed by counting the number of normal motor neurons and white matter damage by the extent of vacuolation. The glial fibrillary acidic protein (GFAP)-positive area fraction (GFAP%) was determined in white and gray matter structures to measure reactive astrogliosis.
    Results: Compared with normothermia, hypothermia significantly improved hind limb function at all assessments (P &lt; .01) and increased numbers of normal gray matter motor neurons (39 +/- 20 vs 99 +/- 13, respectively; P &lt; .001), decreased the percentage area of white matter vacuolation (9.0% +/- 2.7% vs 1.6% +/- 1.3%, respectively; P = .001), and decreased the GFAP% in gray (P = .003) and white matter (P = .009).
    Conclusions: Prophylactic mild hypothermia (1 C reduction in body temperature) preserved hind limb motor function and reduced neuronal death, white matter vacuolation, and astrogliosis in gray and white matter induced by spinal cord ischemia in rats. Thus, mild hypothermia may be useful for perioperative management of thoracoabdominal aortic surgery. (J Vasc Surg 2013;57:173-81.)
    Clinical Relevance: Hypothermia (3 degrees-4 degrees C decrease in temperature) is known to protect the spinal cord from ischemia-reperfusion injury; however, hypothermia can also cause serious secondary complications. In this study, a 1 degrees C reduction in body temperature induced before spinal cord ischemia provided marked and persisting neuroprotection and reduced gliosis, without adverse effects. These data suggest that very mild hypothermia may be applied clinically to avoid systemic complications.

    DOI: 10.1016/j.jvs.2012.05.101

    Web of Science

    researchmap

  • 1.難治性気胸を合併した特発性肺線維症に, EWSを用いた気管支充填術を行った1例(第56回 日本呼吸器内視鏡学会北陸支部会)

    月岡 啓輔, 森山 寛史, 青木 信将, 岡島 正明, 小屋 俊之, 中山 秀章, 各務 博, 高田 俊範, 成田 一衛, 星野 芳史, 佐藤 征二郎, 小池 輝元, 橋本 毅久, 土田 正則, 鈴木 栄一, 大橋 和政, 小林 義昭

    気管支学   35 ( 4 )   460 - 460   2013

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器内視鏡学会  

    DOI: 10.18907/jjsre.35.4_460_1

    CiNii Article

    researchmap

  • 遠位弓部、下行大動脈、胸腹部大動脈瘤の重複瘤に対して開窓付きstentgraftを用いて一期的にTEVARを行った1症例

    岡本 竹司, 大久保 由華, 横井 良彦, 堀 祐郎, 青木 賢治, 名村 理, 榛澤 和彦, 土田 正則

    日本血管外科学会雑誌   21 ( 7 )   858 - 858   2012.12

     More details

    Language:Japanese   Publisher:(NPO)日本血管外科学会  

    researchmap

  • 臨床病期IA期非小細胞肺癌に対する縮小手術後の局所再発関連因子解析

    小池 輝元, 佐藤 征二郎, 橋本 毅久, 土田 正則, 白戸 亨, 篠原 博彦, 吉谷 克雄, 小池 輝明

    肺癌   52 ( 5 )   578 - 578   2012.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 定位放射線治療後の転移性肺腫瘍再増大に対する1切除例

    橋本 毅久, 佐藤 征二郎, 小池 輝元, 土田 正則, 川口 弦

    肺癌   52 ( 6 )   978 - 978   2012.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 抗凝固・抗血小板療法中の肺癌患者の周術期管理

    橋本 毅久, 佐藤 征二郎, 小池 輝元, 土田 正則

    肺癌   52 ( 5 )   679 - 679   2012.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • 肺大細胞神経内分泌癌に対する外科治療

    小池 輝元, 佐藤 征二郎, 橋本 毅久, 斎藤 正幸, 吉谷 克雄, 小池 輝明, 土田 正則

    肺癌   52 ( 5 )   598 - 598   2012.10

     More details

    Language:Japanese   Publisher:(NPO)日本肺癌学会  

    researchmap

  • ECMOを使用した呼吸器外科手術症例の経験

    白戸 亨, 篠原 博彦, 橋本 毅久, 土田 正則

    日本呼吸器外科学会雑誌   26 ( 3 )   P36 - 06   2012.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 肺分画症に対する区域切除術

    橋本 毅久, 白戸 亨, 篠原 博彦, 土田 正則

    日本呼吸器外科学会雑誌   26 ( 3 )   V20 - 05   2012.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • O2-3 当科での肺切除における気管支断端瘻発症例の検討(外科手術1,一般口演2,第35回日本呼吸器内視鏡学会学術集会)

    篠原 博彦, 橋本 毅久, 白戸 亨, 土田 正則

    気管支学   34   S139   2012

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器内視鏡学会  

    DOI: 10.18907/jjsre.34.Special_S139_3

    CiNii Article

    researchmap

  • 6.右肺癌に対し下葉切除後,早期に気管浮腫による狭窄を来し気管切開を要した1例(第53回 日本呼吸器内視鏡学会北陸支部会)

    篠原 博彦, 橋本 毅久, 白戸 亨, 土田 正則

    気管支学   34 ( 1 )   89 - 89   2012

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器内視鏡学会  

    DOI: 10.18907/jjsre.34.1_89

    CiNii Article

    researchmap

  • 7. 血管塞栓用コイルにて治癒した術後気管支断端瘻の1例(第54回 日本呼吸器内視鏡学会北陸支部会)

    篠原 博彦, 橋本 毅久, 白戸 亨, 土田 正則

    気管支学   34 ( 4 )   408 - 408   2012

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器内視鏡学会  

    DOI: 10.18907/jjsre.34.4_408_2

    CiNii Article

    researchmap

  • Status of Lung Cancer in Niigata Prefecture

    Koike Teruaki, Yoshiya Katsuo, Shinohara Hirohiko, Shirato Toru, Yokoyama Akira, Takenouchi Tatsuya, Tsuchida Masanori, Toyabe Shin-ichi, Yamazaki Osamu, Wakatsuki Michihide

    JJLC   52 ( 7 )   1001 - 1006   2012

     More details

    Language:Japanese   Publisher:The Japan Lung Cancer Society  

    <i><b>Objective</b></i>. The statistics of lung cancer incidence rates, treatment results, and survival rates in Japan are well documented; however, the subject of each statistics is not the same. In Niigata Prefecture, it is possible to obtain the above mentioned statistics based on similar subjects. For this reason, we reviewed the statistics of lung cancer in Niigata Prefecture. <i><b>Material and Methods</b></i>. We analyzed the data of the Japanese Association of Cancer Registries of Niigata Prefecture and the Niigata-Prefecture Surgical Resection of Lung Cancer Cohort Study, and reviewed the changes in the statistics of lung cancer in Niigata Prefecture from 1991. <i><b>Results</b></i>. In Niigata Prefecture, lung cancer was the leading cause of death from cancer, and the mortality rate was consistent with the national rate. The 5-year survival rate of lung cancer patients improved over time, and was estimated to be 29.0% in 2000 and 2004. The main cause of the improvement was the increase in the detection rate of early-stage small-sized lung cancers and their successful treatment by surgical resection. <i><b>Conclusion</b></i>. The survival rate of lung cancer patients in Niigata Prefecture improved over time with the increase in the detection rate of early-stage small-sized lung cancers.<br>

    DOI: 10.2482/haigan.52.1001

    CiNii Article

    researchmap

    Other Link: http://search.jamas.or.jp/link/ui/2013338825

  • Reduction of Spinal Cord Ischemia/Reperfusion Injury with Simvastatin in Rats Reviewed

    Takeshi Saito, Masanori Tsuchida, Shino Umehara, Tatsuro Kohno, Hiroshi Yamamoto, Jun-ichi Hayashi

    ANESTHESIA AND ANALGESIA   113 ( 3 )   565 - 571   2011.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    BACKGROUND: Surgery of the thoracic or thoracoabdominal aorta may cause spinal cord ischemia and subsequent paraplegia. However, conventional strategies for preventing paraplegia due to spinal cord ischemia provide insufficient protection and cause additional side effects. We hypothesized that simvastatin, a drug recently shown to be neuroprotective against brain ischemia/reperfusion, would be neuroprotective in a rat spinal cord ischemia/reperfusion model.
    METHODS: Rats were randomly assigned to simvastatin, vehicle, or sham-surgery (sham) groups (n = 6 per group). Simvastatin (10 mg/kg) or vehicle was administered subcutaneously once daily for 7 days before aortic balloon occlusion, and once at 24 hours after reperfusion. Spinal cord ischemia was induced by balloon inflation of a 2F Fogarty catheter in the thoracic aorta, and the proximal mean arterial blood pressure was maintained at 40 mm Hg for 12 minutes. The sham group received the same operation without inflation of the balloon. Ischemic injury was assessed by hindlimb motor function using the Motor Deficit Index score at 6 to 48 hours after ischemic reperfusion, and histological assessment of the spinal cord was performed 48 hours after reperfusion.
    RESULTS: The Motor Deficit Index scores at 24 and 48 hours after reperfusion were significantly improved in the simvastatin group compared with the vehicle group (P = 0.021 and P = 0.023, respectively). Furthermore, there were significantly more normal motor neurons in the simvastatin group than in the vehicle group (P = 0.037). The percentage area of white matter vacuolation was significantly smaller in the simvastatin group than in the vehicle group (P = 0.030).
    CONCLUSIONS: Simvastatin treatment can attenuate hindlimb motor dysfunction and histopathological changes in spinal cord ischemia/reperfusion injury in rats. (Anesth Analg 2011; 113: 565-71)

    DOI: 10.1213/ANE.0b013e318224ac35

    Web of Science

    PubMed

    researchmap

  • 当科での胸膜肺全摘術症例の検討

    篠原 博彦, 土田 正則, 橋本 毅久, 林 純一

    日本呼吸器外科学会雑誌   25 ( 3 )   P52 - 06   2011.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • 同時性両側肺癌に対する右上葉切除後の左胸腔鏡下上区切除術 3DCTによる血管把握の有用性

    橋本 毅久, 土田 正則, 三村 慎也, 篠原 博彦, 林 純一

    日本呼吸器外科学会雑誌   25 ( 3 )   RV07 - 01   2011.4

     More details

    Language:Japanese   Publisher:(NPO)日本呼吸器外科学会  

    researchmap

  • Operative treatment for metachronous pulmonary metastasis from esophageal carcinoma Reviewed

    Hiroshi Ichikawa, Shin-ichi Kosugi, Satoru Nakagawa, Tatsuo Kanda, Masanori Tsuchida, Teruaki Koike, Otsuo Tanaka, Katsuyoshi Hatakeyama

    SURGERY   149 ( 2 )   164 - 170   2011.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MOSBY-ELSEVIER  

    Background. The clinical significance of operative treatment for metachronous pulmonary metastasis from esophageal carcinoma is unclear.
    Methods. We retrospectively reviewed 23 consecutive patients who underwent operative resection for metachronous pulmonary metastasis from esophageal carcinoma from 1991 to 2008. Patient baseline characteristics, survival probability, and prognostic factors were analyzed. The median follow-up period was 31 months for surviving patients.
    Results. There were 19 men and 4 women, with a median age of 66 years at the time of pulmonary resection. The median disease-free interval was 15.5 months. Cervical or mediastinal lymph node metastases preceded pulmonary metastases in 4 patients. Seven patients (30.4%) had multiple metastases with a maximum number of 4. The median operative time and blood loss were 94.5 minutes and 18 mL, respectively. The median length of postoperative stay was 12.5 days. The predicted 1-, 3-, and 5-year survival rates using the Kaplan-Meier method were 73.9%, 43.5%, and 43.5%, respectively, with a median survival time of 28.7 months. Univariate analysis revealed that an extrapulmonary metastasis as the initial recurrence site was an unfavorable prognostic factor (P = .0411). Multivariate analyses, however, did not identify the initial recurrence site as an independent prognostic factor (P =. 0542).
    Conclusion. Operative resection for metachronous pulmonary metastasis from esophageal carcinoma is an acceptable treatment. This study of a limited number of patients may have created a constitutional selection bias. An antecedent extrapulmonary metastasis was found to be an unfavorable prognostic factor. (Surgery 2011;149:164-70.)

    DOI: 10.1016/j.surg.2010.07.047

    Web of Science

    PubMed

    researchmap

  • The predominant expression of hepatocyte nuclear factor 4 alpha (HNF4 alpha) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma Reviewed

    Ryosuke Kunii, Shuying Jiang, Go Hasegawa, Takashi Yamamoto, Hajime Umezu, Takehiro Watanabe, Masanori Tsuchida, Takehisa Hashimoto, Takao Hamakubo, Tatsuhiko Kodama, Keisuke Sasai, Makoto Naito

    HISTOPATHOLOGY   58 ( 3 )   467 - 476   2011.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-BLACKWELL  

    Aims:
    To investigate TTF-1-negative pulmonary adenocarcinoma, focusing upon mucin production and the expression of hepatocyte nuclear factor-4 alpha (HNF4 alpha).
    Materials and methods:
    Two hundred and sixty-two cases of pulmonary adenocarcinoma were examined histologically and immunohistochemically; TTF-1 was expressed in 222 cases (84.7%), and 40 cases (15.3%) were negative. Among TTF-1-negative cases there were 31 mucinous-type tumours, and HNF4 alpha, MUC5AC and MUC2 were expressed in 34 cases (85%), 29 cases (72.5%) and four cases (10%), respectively. In contrast, their expression was rare in TTF-1-positive tumours. A statistically inverse correlation was confirmed between the expression of TTF-1 and that of HNF4 alpha and MUC5AC.
    Conclusion:
    Most TTF-1-negative pulmonary adenocarcinomas are mucinous lesions with the predominant expressionof HNF4 alpha and MUC5AC.

    DOI: 10.1111/j.1365-2559.2011.03764.x

    Web of Science

    PubMed

    researchmap

  • [Surgical treatment for metachronous lung cancer]. Reviewed

    Shinohara H, Tsuchida M, Hashimoto T, Hayashi J

    Kyobu geka. The Japanese journal of thoracic surgery   63 ( 11 )   952 - 955   2010.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:11  

    We performed a retrospective review of 45 consecutive patients with metachronous multiple primary lung cancer who underwent resection between 1990 and 2009. Surgical treatment of the 1st tumor consisted of 39 lobectomies and 3 segmentectomies, and 3 wedge resections. The 2nd tumor was removed by means of a lobectomy in 9 patients, a segmentectomy in 17 patients, a wedge resection in 19 patients. No postoperative mortality was observed. Histologic classification was similar in 86.4% of patients and different in 13.6%. Postoperative stage of the 2nd tumor was IA in 31 patients, IB in 7, IIA in 1, IIIA in 3, IIIB in 3. Median follow-up was 48.4 months after 2nd operation. The 5-year survival rate was 90.8% after 1st operation and 85.6% after 2nd operation. The 5-year survival rate in patients with p-stage IA was 96.4%. Patients with metachronous lung cancer could have a favorable outcome. Thus we need careful follow-up of the patients after treatment on the 1st lung cancer, and moreover an aggressive surgical treatment is recommended as long as their performance state or residual pulmonary function allows.

    PubMed

    researchmap

  • Primary thymic adenocarcinoma coexisting with type AB thymoma: A rare case with long-term survival Reviewed

    Yasuko Hosaka, Masanori Tsuchida, Hajime Umezu, Tadaaki Eimoto, Takehisa Hashimoto, Hirohiko Shinohara, Jun-Ichi Hayashi

    General Thoracic and Cardiovascular Surgery   58 ( 9 )   488 - 491   2010.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:9  

    Thymic carcinoma is a rare tumor. The most common histological subtype is squamous cell carcinoma, and only a few cases of thymic adenocarcinoma have been reported. A case of papillary adenocarcinoma of thymic origin that coexisted with type AB thymoma as a separate nodule is presented herein. The patient was found to have an abnormal mediastinal shadow on chest X-ray. A computed tomography scan revealed a round, 6.5-cm-diameter mass in the right anterior mediastinum. The preoperative diagnosis was thymoma, and thymothymectomy was performed. On pathological examination, two tumors, which were diagnosed as papillary adenocarcinoma and type AB thymoma, respectively, were present in the thymus without any connection with each other. The patient has been alive without any signs of recurrence for 11 years after surgery. We diagnosed the adenocarcinoma in this case was a primary thymic carcinoma. © 2010 The Japanese Association for Thoracic Surgery.

    DOI: 10.1007/s11748-009-0580-4

    Scopus

    PubMed

    CiNii Article

    researchmap

  • Endobronchial metastasis from adenocarcinoma of gastric cardia 7 years after potentially curable resection. Reviewed International journal

    Hanyu T, Kanda T, Matsuki A, Hasegawa G, Yajima K, Tsuchida M, Kosugi S, Naito M, Hatakeyama K

    World journal of gastrointestinal surgery   2 ( 8 )   270 - 274   2010.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:8  

    Endobronchial metastasis (EBM) is a rare form of metastasis from extrapulmonary malignant tumors, although there are few reports of EBM from gastric cancer specifically. We report the case of a 51-year-old woman who had undergone gastrectomy for advanced gastric cancer seven years previously but was diagnosed with a solitary lung tumor by follow-up computed tomography. On diagnosis of primary lung cancer, she underwent pulmonary lobectomy, but immunohistochemical examination confirmed the resected tumor to be an EBM from the gastric cancer. Six months later, she was diagnosed with peritoneal metastases and underwent chemotherapy with gastric cancer regimen. She is still alive at 33 mo after the lobectomy. Generally, the prognosis for EBM is poor although multidisciplinary treatment can lead to long-term survival. Precise diagnosis on the basis of detailed pathological and immunohistochemical evaluation can contribute to deciding the most effective treatment and improving prognosis.

    DOI: 10.4240/wjgs.v2.i8.270

    PubMed

    researchmap

  • Three cases of sleeve segmentectomy for central-type squamous cell carcinoma with impaired lung function due to COPD

    NAGASAWA Ayako, TSUCHIDA Masanori, HASHIMOTO Takehisa, SHINOHARA Hirohiko, HAYASHI Jun-ichi

    The Journal of the Japanese Association for Chest Surgery   24 ( 2 )   229 - 235   2010.3

     More details

    Language:Japanese   Publisher:The Japanese Association for Chest Surgery  

    Sleeve segmentectomy for central-type squamous cell carcinoma of the lung was performed in three patients with impaired lung function. All patients were male, and their preoperative FEV<SUB>1.0</SUB> (FEV<SUB>1.0%</SUB>) was 1,070 ml (37.8%), 1,020 ml (41.0%), and 1,240 ml (51.2%), respectively. Since the predicted postoperative FEV<SUB>1.0</SUB> after lobectomy was estimated to be less than 700 ml/m<SUP>2</SUP> in each case, sleeve segmentectomy was performed to preserve the lung function as much as possible. The surgical procedures were S<SUP>6</SUP> segmentectomy with bronchoplasty, sleeve segmentectomy of the left superior segment, and sleeve segmentectomy of the left apical segment (S<SUP>1+2</SUP>). The pathological stage was I B, II B, and I A. Two patients were alive without any evidence of recurrence fifty and eighty-one months after surgery. One patient died of gastric cancer without the recurrence of lung cancer.

    DOI: 10.2995/jacsurg.24.229

    CiNii Article

    CiNii Books

    researchmap

    Other Link: http://search.jamas.or.jp/link/ui/2010149090

  • Masaoka Stage and Histologic Grade Predict Prognosis in Patients With Thymic Carcinoma Reviewed

    Yasuko Hosaka, Masanori Tsuchida, Shin-ichi Toyabe, Hajime Umezu, Tadaaki Eimoto, Jun-ichi Hayashi

    ANNALS OF THORACIC SURGERY   89 ( 3 )   912 - 917   2010.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Background. Thymic carcinoma is a rare tumor. Limited data are available regarding the effectiveness of treatment and the prognosis of thymic carcinoma. The present study aimed to clarify the prognostic factors in patients who underwent resection.
    Methods. The study retrospectively reviewed 21 patients (15 men, 6 women) with thymic carcinoma who had undergone resection at Niigata University Hospital.
    Results. Masaoka stage was II in 4 patients, III in 9, IVa in 2, and IVb in 6. Histologic subtypes were squamous cell carcinoma in 14 patients, adenocarcinoma in 2, atypical carcinoid in 3, and undifferentiated carcinoma in 2. Histologic grade by degree of differentiation was low in 4 tumors, intermediate in 12, and high in 5. Treatment comprised resection alone in 6 patients and resection along with multimodal therapies in 15. Complete resection was achieved in 14 (67%). Eight patients died of tumor. Recurrence was documented in 7 of 14 patients with complete resection, and 5 received additional treatment. The overall 5-year survival rate was 61.1%, and the disease-free 5-year survival rate was 66.8% for the 14 with complete resection. By multivariate analysis, Masaoka stage and histologic grade were significant independent prognostic factors for overall survival.
    Conclusions. The surgical outcome of patients with thymic carcinoma depends on the Masaoka stage and histologic grade. Patients with early Masaoka stage and low or intermediate histologic grade had favorable prognoses. (Ann Thorac Surg 2010;89:912-7) (C) 2010 by The Society of Thoracic Surgeons

    DOI: 10.1016/j.athoracsur.2009.11.057

    Web of Science

    PubMed

    researchmap

  • [Induction chemoradiation followed by resection through anterior approach for superior sulcus tumor]. Reviewed

    Tsuchida M, Hashimoto T, Shinohara H, Hosaka Y, Satoh S, Shirato T, Kitahara A, Hayashi J

    Kyobu geka. The Japanese journal of thoracic surgery   63 ( 1 )   29 - 33   2010.1

     More details

  • Protective mechanism of ultrafiltration against cardiopulmonary bypass-induced lung injury

    Koike T, Tsuchida M, Saitoh M, Haga M, Satoh K, Aoki T, Toyabe SI, Hayashi JI

    Transplant Proc   41 ( 9 )   3845 - 3848   2009.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.transproceed.2009.04.010

    researchmap

  • Large bronchial granular cell tumor Reviewed

    Hirohiko Shinohara, Masanori Tsuchida, Takehisa Hashimoto, Seijirou Satoh, Mariko Takeshige, Jun-Ichi Hayashi

    General Thoracic and Cardiovascular Surgery   57 ( 9 )   484 - 487   2009.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:9  

    We report a 20-year-old woman who underwent complete resection of a granular cell tumor (GCT). On chest computed tomography (CT) scan, a mass with a maximum diameter of 36 mm at the lower bronchus with atelectasis of the right lower lobe was noted. Bronchoscopic examination revealed a whitish mass in the truncus intermedius, and the middle and lower bronchus were unable to be seen. A cytopathological examination of the mass revealed GCT. A right middle and lower lobectomy was performed via a posterolateral thoracotomy. Microscopically, the tumor was composed of polygonal cells with oxyphilic granular cytoplasm and small ovoid nuclei. The cytoplasm of the neoplastic cells was positive for S-100 protein and neuron-specific enolase. The patient's postoperative course was uneventful, and she was asymptomatic after 4 months. A large bronchial GCT is rare, which is why we report this case. © 2009 The Japanese Association for Thoracic Surgery.

    DOI: 10.1007/s11748-009-0428-y

    Scopus

    PubMed

    CiNii Article

    researchmap

  • Superior vena cava reconstruction via a posterolateral thoracotomy without venous occlusion for locally advanced lung cancer: Report of a case Reviewed

    Hirohiko Shinohara, Masanori Tsuchida, Takehisa Hashimoto, Seijirou Satoh, Ai Takeuchi, Mariko Takeshige, Jun-ichi Hayashi

    SURGERY TODAY   39 ( 9 )   787 - 789   2009.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    We performed a right upper lobectomy with prosthetic replacement of the superior vena cava (SVC) through a posterolateral thoracotomy in a 65-year-old man undergoing complete resection of a locally advanced non-small-cell lung cancer with invasion of the SVC. Instead of using a vascular shunt, the right atrium and a right brachiocephalic vein (BCV) were anastomosed using a ringed polytetrafluoroethylene (PTFE) graft. During the anastomosis, vascular flow was maintained through the left BCV. By using this technique, SVC resection and reconstruction during lung cancer surgery can be safely performed through a posterolateral thoracotomy without blood flow interruption.

    DOI: 10.1007/s00595-008-3927-z

    Web of Science

    PubMed

    researchmap

  • Analysis of resected primary lung cancer in Niigata Prefecture in 2001 Reviewed

    Masaaki Inoue, Teruaki Koike, Takehiro Watanabe, Kenichi Togashi, Atsushi Fujita, Masanori Tsuchida, Tadashi Aoki, Shinpei Yoshii, Jun-Ichi Hayashi

    Japanese Journal of Lung Cancer   49 ( 2 )   174 - 182   2009.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Objective. To improve surgical related mortality, Niigata Chest Surgery Group registered primary lung cancer patients who were operated on in 2001 and prospectively analyzed these patients. Patients. A total of 558 primary lung cancer patients underwent resection between January 2001 and December 2001. Results. There were 352 men (63.1%) and 206 women (36.9%), with an overall median age of 66.7 years. The overall 5-year survival rate was 65.1%, 55.8% in men and 80.9% in women. Complications related to operations were observed in 37 cases (6.6%) and the operative mortality was 0.7% (4 cases). The 5-year survival rates, in relation to reason for detection were as follows: Screening group (n = 284)
    75.5%, Other disease group (n = 175)
    57.3%, Symptomatic group (n = 99)
    48.8%. The 5-year survival rates estimated by p-stage were: IA (n = 297)
    79.9%, IB (n = 124)
    67.4%, IIA (n = 16)
    66.7%, IIB (n = 40)
    27.5%, IIIA (n = 47)
    32.7%, IIIB (n = 21)
    23.8%, IV (n = 13)
    0.0%. The 5-year survival rates according to histologic type were: adenocarcinoma 69.5% (n = 388), squamous cell carcinoma 52.1% (n = 128), large cell carcinoma 61.5% (n = 13), small cell carcinoma 71.4% (n = 7), carcinoid 62.5% (n = 8), and others 64.3% (n = 14). Conclusion. We determined the characteristics of lung cancer patients and the results of their operative treatment in Niigata Prefecture. We anticipate registering more lung cancer patients to expand this database of patients. The availability of this database should help to improve the lung cancer treatment in Niigata Prefecture. © 2009 The Japan Lung Cancer Society.

    DOI: 10.2482/haigan.49.174

    Scopus

    researchmap

  • Expression of 5-fluorouracil-related enzymes in lung cancer: ELISA characterizes enzyme activity and messenger RNA expression Reviewed

    Masanori Tsuchida, Yasushi Yamato, Takehisa Hashimoto, Hirohiko Shinohara, Hajime Umezu, Katsuo Yoshiya, Teruaki Koike, Jun-Ichi Hayashi

    ONCOLOGY REPORTS   21 ( 4 )   1037 - 1043   2009.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPANDIDOS PUBL LTD  

    The enzymes thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) are involved in the metabolism of the anticancer drug 5-fluorouracil (FU). Expression of TS, DPD and OPRT in cancer tissue has been reported to be associated with sensitivity and/or resistance to 5-FU therapy. However, the role of TS, DPD and OPRT expression in lung cancer has not been fully established. Furthermore, among several measuring methods, it is not clear which method effectively predicts the response to 5-FU therapy. The aim of this study was to analyze the expression of 5-FU-related enzymes using enzyme-linked immunosorbent assay (ELISA) and to examine the correlation of ELISA and the results obtained using different measuring methods such as reverse transcript polymerase chain reaction (RT-PCR), immunohistochemistry, and enzymatic activity. Lung cancer specimens were obtained from 134 patients who underwent curative resection for lung cancer. As a pilot study, enzyme expression of 11 samples was measured using 4 different methods for DPD: RT-PCR, immunohistochemistry, enzymatic activity and ELISA. The relationships between pairs of results were compared, and then enzyme protein expression was measured using ELISA in 119 patients with adenocarcinoma. Of the 4 independent methods, the highest correlation was observed between protein expression measured by ELISA and enzyme activity. The correlation of gene expression and ELISA was also significant. The protein level in stage I adenocarcinoma measured using ELISA was 13.0+/-24.8 ng/mg protein for TS, 362.2+/-264.3 ng/mg protein for DPD and 4.5+/-2.0 ng/mg protein for OPRT. The predictive value of the enzymes for prognosis and the effectiveness of 5-FU was not determined as few recurrences were observed during the short follow-up period. In conclusion, ELISA is a simple and reliable method to measure key enzymes related to 5-FU therapy.

    DOI: 10.3892/or_00000321

    Web of Science

    researchmap

  • Absence of gene mutations in KIT-positive thymic epithelial tumors Reviewed

    Masanori Tsuchida, Hajime Umezu, Takehisa Hashimoto, Hirohiko Shinohara, Terumoto Koike, Yasuko Hosaka, Tadaaki Eimoto, Jun-ich Hayashi

    LUNG CANCER   62 ( 3 )   321 - 325   2008.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    Background: Overexpression of KIT, a tyrosine kinase receptor protein encoded by the protooncogene c-kit, is observed in human neoplasms such as gastrointestinal stromal. tumors (GISTs), myetoproliferative disorders, melanoma and seminoma. In patients with GIST, overexpression of mutated KIT within the tumor is predictive of response to molecular targeted therapy using imatinib. However, the rote of KIT expression in thymic carcinoma is not fully understood.
    Methods: Thymic epithelial. tumors from 37 patients (17 thymic carcinomas and 20 thymomas) were examined. Immunohistochemical staining with anti-KIT polyclonal antibody and anti-CD5 was performed. Mutation analyses in the juxtamembrane domains, exons 9 and 11, and in the tyrosine kinase domains, exons 13 and 17, were undertaken using polymerase chain reaction (PCR) and direct DNA sequencing in KIT-positive samples.
    Results: KIT- and CD5-positive staining was observed only in thymic carcinoma. Percentage of positive staining was 100% in squamous cell carcinoma, with no positive staining in other histologies, including atypical carcinoid. Mutation analysis of the KIT gene was performed in 11 squamous cell carcinomas, 1 adenocarcinoma and 1 adenosquamous ceit carcinoma. None of the tested samples showed mutations in any of the four exons.
    Conclusions: Squamous cell carcinoma of the thymus frequently expressed KIT and CD5 proteins, whereas other tumors did not. Unlike GIST, overexpression of KIT does not necessarily indicate gene mutation in thymic carcinoma. KIT and CD5 appear useful for evaluating and subtyping thymic epithelial, tumors. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.lungcan.2008.03.035

    Web of Science

    researchmap

  • A case of descending necrotizing mediastinitis arising from odontogenic infection with NSAID-induced gastric ulcer in a very elderly patient

    KODAMA Yasumitsu, ONO Kazuhiro, ARASHIYAMA Takanori, OSEKI Koushi, TSUCHIDA Masanori, TAKAGI Ritsuo

    Jpn. J. Oral. Maxillofac. Surg.   54 ( 9 )   541 - 545   2008.9

     More details

    Language:Japanese   Publisher:社団法人 日本口腔外科学会  

    We describe an 88-year-old woman with gas-forming submental cellulitis in whom nonsteroidal antiinflammatory drug (NSAID)-induced gastric ulcer led to hemorrhagic shock during treatment of an odontogenic infection. Hemodynamic treatment had to take priority, and intensive treatment for inflammation could not be performed. This apparently led to the development of descending necrotizing mediastinitis. During the six days of hospitalization, she took a total of 6 tablets of loxoprofen sodium (60 mg) and 1 diclofenac sodium suppository (25 mg) for analgesia after treatment.&lt;BR&gt;Retrospectively, if decisive and aggressive treatment for inflammation had been performed earlier after hospitalization, inflammation may have resolved sooner. Our experience reconfirms that the initial treatment of odontogenic infection is extremely important in very elderly patients. Even if NSAIDs are received for a short period of time in small doses, gastrointestinal hemorrhage can occur, as in our patient. Patients at high risk for gastrointestinal ulcer should receive prophylactic treatment with cyclo-oxygenase 2 inhibitors orproton pump inhibitors.Generally, very elderly patients have a high risk of complications because of considerable age-related declines in physical ability and functional reserve of organs. Very cautious treatment is therefore necessary.

    DOI: 10.5794/jjoms.54.541

    CiNii Article

    CiNii Books

    researchmap

  • A resected case of mediastinal hemangiopericytoma Reviewed

    Seijiro Sato, Masanori Tsuchida, Mariko Takeshige, Hirohiko Shinohara, Takehisa Hashimoto, Yoichi Ajioka, Kenzo Hiroshima

    Japanese Journal of Lung Cancer   48 ( 4 )   339 - 340   2008.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2482/haigan.48.339

    Scopus

    researchmap

  • Segmentectomy for multiple adenocarcinoma presenting as ground-glass opacities after lung cancer surgery Reviewed

    Ai Takeuchi, Masanori Tsuchida, Takehisa Hashimoto, Hirohiko Shinohara, Jun-Ichi Hayashi

    General Thoracic and Cardiovascular Surgery   56 ( 8 )   410 - 412   2008.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    During follow-up of patients after primary lung cancer resections, small nodules or ground-glass opacities (GGOs) are sometimes detected on chest computed tomography. We report a case with multiple GGOs that were noted after primary lung cancer resection. A 76-year-old woman, who had undergone right upper lobectomy, middle lobe partial resection, and mediastinal lymph node dissection 3 years earlier, was admitted owing to five GGOs in the right lower lobe that had been increasing in size or density. A right S6+10 segmentectomy was performed. On histology, one adenocarcinoma and four bronchioloalveolar carcinomas (BACs), as well as two additional BACs that had not been detected preoperatively, were identified. No complications occurred postoperatively. Three years 4 months later, no tumor recurrence or new lesions have been found. Given the high possibility of malignancy, the appearance of new GGOs in patients with a history of lung cancer requires appropriate investigation. © 2008 The Japanese Association for Thoracic Surgery.

    DOI: 10.1007/s11748-008-0257-4

    Scopus

    PubMed

    researchmap

  • Electroporation-mediated transfer of plasmid DNA encoding IL-10 attenuates orthotopic tracheal allograft stenosis in rats Reviewed

    Masanori Tsuchida, Terumoto Koike, Masaru Takekubo, Hiroyuki Hirahara, Haruo Hanawa, Hiroki Maruyama, Jun-ichi Miyazaki, Jun-ichi Hayashi

    TRANSPLANT IMMUNOLOGY   19 ( 3-4 )   173 - 177   2008.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Background: Electroporation has been shown to increase the efficacy of intramuscular injection of plasmid DNA, resulting in a higher level of foreign gene expression. Using this technique, we examined the effect of viral IL-10 gene transfer on the prevention of tracheal allograft stenosis in an animal model.
    Methods: On the day of tracheal transplantation, recipient Lewis rats were intramuscularly injected with either plasmid pCAGGS-LacZ or plasmid pCAGGS-viral IL-10, followed immediately by electroporation. Tracheas from Brown Norway donors were transplanted into the backs of Lewis recipients, and the histology of the grafts were assessed 2 and 4 weeks after transplantation.
    Results: The serum level of IL-10 peaked at 2000 pg/ml one day after injection: the level then slowly decreased, but was maintained above 1000 pg/ml until 8 days after injection. At Day 28, the airway lumina of the tracheal allografts were almost completely obliterated by fibroproliferative tissue in the control pCAGGS-LacZ-treated rats. In rats injected once with pCAGGS-viral IL-10, luminal obliteration was significantly decreased compared with the control pCAGGS-LacZ-treated rats (mean luminal opening 46.8% vs 0% p&lt;0.05). The loss of epithelial cells lining the airway was also decreased in the IL-10-treated group (mean epithelial coverage 42% vs 5% p&lt;0.05). Multiple injections with pCAGGS-viral IL-10 did not further improve the histological changes.
    Conclusion: IL-10 gene transfer by intramuscular injection using electroporation attenuated tracheal allograft stenosis associated with mild epithelial injury. (C) 2008 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.trim.2008.05.001

    Web of Science

    PubMed

    researchmap

  • 3ヶ所の亜区域支閉塞を認めた気管支閉鎖症の1切除例

    白戸 亨, 長澤 綾子, 杉本 愛, 保坂 靖子, 小池 輝元, 篠原 博彦, 橋本 毅久, 土田 正則, 林 純一

    日本胸部外科学会関東甲信越地方会要旨集   ( 146回 )   26 - 26   2008.6

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • A case of osteomyelitis of the chest wall due to resection and radiation therapy for breast cancer

    SHINOHARA Hirohiko, TSUCHIDA Masanori, HASHIMOTO Takehisa, SATO Seijirou, TAKEUCHI Ai, TAKESHIGE Mariko, HAYASHI Jun-ichi

    The Journal of the Japanese Association for Chest Surgery   22 ( 4 )   91 - 94   2008.5

     More details

    Language:Japanese   Publisher:The Japanese Association for Chest Surgery  

    We report a case of osteomyelitis on the anterior chest wall after resection and radiation therapy for breast cancer. A 65-year-old woman underwent radical mastectomy with postoperative irradiation for breast cancer 24 years ago. A radiation-induced ulcer on the right anterior chest wall was noted. About 2 years ago, a full-thickness ulcer with rib exposure developed, and bleeding was seen 3 months ago, and so she was admitted to our hospital. Anterior chest wall resection and reconstruction using a latissimus dorsi myocutaneous flap was performed. She is currently well without any evidence of recurrence.

    DOI: 10.2995/jacsurg.22.705

    CiNii Article

    CiNii Books

    researchmap

    Other Link: http://search.jamas.or.jp/link/ui/2008239085

  • Hydrodynamics-based delivery of plasmid DNA encoding CTLA4-Ig prolonged cardiac allograft survival in rats. Reviewed

    Takekubo M, Tsuchida M, Haga M, Saitoh M, Hanawa H, Maruyama H, Miyazaki J, Hayashi J

    The journal of gene medicine   10 ( 3 )   290 - 297   2008.3

  • Influence of normothermic cardiopulmonary bypass on body oxygen metabolism during lung transplantation Reviewed

    Koichi Sato, Masanori Tsuchida, Masayuki Saito, Terumoto Koike, Jun-Ichi Hayashi

    ASAIO JOURNAL   54 ( 1 )   73 - 77   2008.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    Studies have demonstrated that cardiopulmonary bypass (CPB) adversely affects pulmonary circulation, which is involved in metabolism in the lung, and that pulmonary circulation after CPB can restore the prostaglandin E2 (PGE2) level mainly standing for levels of key vasostimulators augmented during CPB, which may influence systemic tissue perfusion and body oxygen metabolism. However, in lung transplantation (Lx), pulmonary circulation is restored to the graft, which might induce another CPB reaction. We prospectively examined the influence of CPB on body oxygen metabolism in Lx. Left Lx was successfully performed on 10 dogs (group-on: with normothermic CPB without cardiac arrest, group-off. without CPB; n = 5 vs. 5). At 30 minutes after graft perfusion, the right pulmonary artery and bronchus were clamped. Body weight, donor-to-recipient body weight ratio, and clinical parameters were comparable between the two groups, except for the hematocrit level during CPB. At 90 minutes after graft perfusion, mixed venous oxygen saturation (SVO2) was lower (p &lt; 0.01) and 02 extraction rate (p &lt; 0.01), PGE2 (p = 0.025), and arterial blood ketone body ratio (KBR) (p &lt; 0.01) were higher in group-on than in group-off, whereas these parameters were comparable before graft perfusion between the two groups. 02 consumption and acetic acid were higher in group-on than in group-off, whereas 0, delivery and 3-hydroxy propioic acid were comparable between the groups. In conclusion, Lx during CPB may induce a new inflammatory reaction and influence body oxygen metabolism, contrary to the restoration of pulmonary circulation after CPB.

    DOI: 10.1097/MAT.0b013e31815b2d36

    Web of Science

    researchmap

  • Pretreatment with olprinone hydrochloride, a phosphodiesterase III inhibitor, attenuates lipopolysaccharide-induced lung injury via an anti-inflammatory effect Reviewed

    Terumoto Koike, Muhammad Nadeen Qutab, Masanori Tsuchida, Masaru Takekubo, Masayuki Saito, Jun-ichi Hayashi

    PULMONARY PHARMACOLOGY & THERAPEUTICS   21 ( 1 )   166 - 171   2008

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD  

    Purpose: Acute respiratory distress syndrome is characterized by neutrophil accumulation in the lungs and the activation of several cytokines produced by macrophages. Olprinone hydrochloride, a specific phosphodiesterase III inhibitor, has anti-inflammatory effects and inhibits the activation of macrophages, in addition to its inotropic and vasodilatory effects. The purpose of this study was to examine the beneficial effects of olprinone on lipopolysaccharide (LPS)-induced pulmonary inflammation.
    Materials and methods: Lung inflammation was produced by intravenous LPS injection into rats. The rats were divided into four groups: it vehicle group in which normal saline wits injected, an olprinone group in which olprinone was injected at it dose of 0.2 mg/kg, a dexamethasone group in which dexamethasone was injected at a dose of 5 mg/kg, and a control group. In each group, drug was injected intraperitoneally 30 min before the intravenous administration of LPS. The blood was obtained at I h and then animals were sacrificed at 6h and blood and ling specimen were obtained for cytokine analysis and pathological examination. On another set of experiment, bronchioloalveolar lavage (BAL) was performed for cytokine analysis of BAL fluid. The macrophages isolated from normal rat by BAL were Cultured in vitro with the presence of LPS and olprinone or dexamethasone. and supernatant was collected. The levels of several cytokines in the serum, in the BAL fluid, and in the culture supernatant were determined.
    Results: The animals injected with LPS were found to have an influx of neutrophils in the lungs, and inflammatory cytokines, such as TNF-alpha and IL-6, and anti-inflammatory cytokine IL-10 were produced. Pretreatment with olprinone or dexamethasone significantly inhibited the LPS-induced neutrophil influx into the lungs, suppressed inflammatory cytokines TNF-alpha and IL-6. The level of anti-inflammatory cytokine IL-10 increased in an olprinone group. The inhibition of TNF-alpha and IL-6, and the augmentation of IL-10 release were also observed in in vitro culture of isolated rat alveolar macrophages when olprinone (10(-5) mol/ml) and LPS (10 mu g/ml) were cultured together. However, the level of IL-10 in serum and Culture Supernatant Was Suppressed in a dexamesathone group.
    Conclusion: LPS-induced lung inflammation is strongly inhibited by olprinone accompanying the enhancement of IL-10 and the inhibition of inflammatory cytokines. Results of the in vitro experiment suggest that alveolar macrophages may play an important role in ameliorating LPS-induced lung inflammation and the mechanism of its effect is different from that of steroid. (C) 2007 Published by Elsevier Ltd.

    DOI: 10.1016/j.pupt.2007.01.007

    Web of Science

    researchmap

  • 1. 縦隔リンパ節腫張を伴った好酸球性肺炎の1例(第45回日本呼吸器内視鏡学会北陸支部会)

    富士盛 文夫, 島岡 雄一, 田島 俊児, 小屋 俊之, 森山 寛史, 田中 純太, 寺田 正樹, 高田 俊範, 下条 文武, 長谷川 隆志, 鈴木 栄一, 竹重 麻里子, 篠原 博彦, 土田 正則, 櫻田 潤子, 梅津 哉

    気管支学   30 ( 1 )   49 - 49   2008

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器内視鏡学会  

    DOI: 10.18907/jjsre.30.1_49_1

    CiNii Article

    researchmap

  • 新潟県内の肺・心肺移植適応患者検討の現状

    土田 正則, 橋本 毅久, 篠原 博彦, 斉藤 正幸, 小池 輝元, 林 純一

    移植   42 ( 総会臨時 )   241 - 241   2007.10

     More details

    Language:Japanese   Publisher:(一社)日本移植学会  

    researchmap

  • Quality of Life after Lung Cancer Surgery: Video-Assisted Thoracic Surgery versus Thoracotomy Reviewed

    Tadashi Aoki, Masanori Tsuchida, Takehisa Hashimoto, Masayuki Saito, Terumoto Koike, Jun-ichi Hayashi

    Heart Lung and Circulation   16 ( 4 )   285 - 289   2007.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Objective: To assess the benefit of video-assisted thoracic surgery (VATS), we compared time-related quality of life (QOL) after lobectomy performed by VATS to that performed by thoracotomy. Methods: Thirty-three patients underwent surgery for lung cancer during the period April 2001 through November 2002 completed a mailed questionnaire after surgery. Results: Over time, improved QOL was reported in six dimensions by VATS patients but in only two dimensions by thoracotomy patients. There was significant improvement in bodily pain subscores in both groups during the 36 months after surgery. At 3 months after surgery, QOL scores for all eight dimensions were lower in the VATS group, but QOL scores for all eight dimensions did not differ significant between groups at 3 or 12 months after surgery. At 36 months after surgery, QOL scores for six dimensions were higher in the VATS group, and the difference was significant in scores for two dimensions. Conclusion: We found recovery was quicker in patients who underwent VATS than in those who underwent thoracotomy. © 2007 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand.

    DOI: 10.1016/j.hlc.2007.02.081

    Scopus

    PubMed

    researchmap

  • Ultrasmall intrapulmonary lymph node: usual high-resolution computed tomographic findings with histopathologic correlation. Reviewed

    Ishikawa H, Koizumi N, Morita T, Tsuchida M, Umezu H, Sasai K

    Journal of computer assisted tomography   31 ( 3 )   409 - 413   2007.5

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1097/01.rct.0000243451.25986.10

    PubMed

    researchmap

  • Lung resection combined with percutaneous coronary intervention using Cypher stents: A case report Reviewed

    Masanori Tsuchida, Takeshi Okamoto, Takehisa Hashimoto, Tadashi Aoki, Takashi Saigawa, Akira Hirono, Jun-ichi Hayashi

    Annals of Thoracic and Cardiovascular Surgery   13 ( 1 )   56 - 59   2007.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:1  

    Treatment of concomitant severe coronary artery disease and lung cancer is a complicated issue. The present study describes a case of a 65-year-old man with coronary artery disease and primary lung cancer that was successfully treated with lung resection and percutaneous coronary intervention (PCI) using Cypher stents. Prior to lung resection, the patient underwent a PCI for diffuse stenosis of the right coronary artery and the circumflex artery. Cypher stents were deployed for both lesions. Five days after stent implantation, a right lower lobectomy was performed successfully. To the best of our knowledge, this is the first report of lung resection and PCI using Cypher stents.

    Scopus

    PubMed

    researchmap

  • A case of pulmonary cryptococcosis with positive FDG-PET scanning in a post-renal transplant patient

    HASHIMOTO Takehisa, OKAMOTO Takeshi, AOKI Tadashi, TSUCHIDA Masanori, HAYASHI Jun-ichi

    The Journal of the Japanese Association for Chest Surgery   21 ( 1 )   80 - 84   2007.1

     More details

    Language:Japanese   Publisher:The Japanese Association for Chest Surgery  

    We report a case of pulmonary cryptococcosis in a renal transplant recipient. A 53-year-old woman with living kidney transplantation had been receiving immunosuppressive therapy with tacrolimus and methylprednisolone. During a regular checkup, a nodular shadow was detected on her chest X-ray film. The chest CT scan revealed a solid nodule in the region of rt. S<SUP>2</SUP> and showed a slightly increased diameter during follow-up. FDG-PET demonstrated an accumulation corresponding to the lesion with an SUV of 3.7 at 60min and 4.2 at 120min post-injection, indicating a possible malignancy. The nodule was resected under video-assisted thoracoscopic surgery and a diagnosis of pulmonary cryptococcosis was obtained. It is sometimes difficult to distinguish lung cancer from pulmonary cryptococcosis because pulmonary cryptococcosis often shows similar image characteristics to lung cancer. In this case, the increased diameter and positive accumulation on FDG-PET suggested malignancy rather than inflammation. Careful differentiation between malignancy and inflammation are necessary in post-transplant patients with abnormal chest shadows.

    DOI: 10.2995/jacsurg.21.080

    CiNii Article

    CiNii Books

    researchmap

    Other Link: http://search.jamas.or.jp/link/ui/2007149475

  • Case of malignant mesothelioma with malignant seeding of chest wall

    TAKEUCHI Ai, AOKI Tadashi, HASHIMOTO Takehisa, TSUCHIDA Masanori, HAYASHI Jun-ichi

    The Journal of the Japanese Association for Chest Surgery   21 ( 1 )   85 - 88   2007.1

     More details

    Language:Japanese   Publisher:The Japanese Association for Chest Surgery  

    A 57-year-old man with a chest wall tumor and right pleural effusion was referred to our hospital. Cytological analysis of the pleural effusion and biopsy of the parietal pleura had already been performed, but no fixed diagnosis was made. The chest wall tumor and the tissue along the tracts of the biopsy needles were removed, and a subsequent thoracoscopic examination was performed. The histological findings of the chest wall tumor led to a diagnosis of biphasic malignant mesothelioma. The clinical stage was T3N0M0 stage III on IMIG-TNM classification. A right extrapleural pneumonectomy was performed. In this case, the histological findings of the chest wall tumor facilitated the final diagnosis.

    DOI: 10.2995/jacsurg.21.085

    CiNii Article

    CiNii Books

    researchmap

    Other Link: http://search.jamas.or.jp/link/ui/2007149476

  • RV-12-3 側方アプローチ,体外循環使用下に左房合併切除を施行した原発性肺癌の1例(拡大手術(2), 第24回日本呼吸器外科学会総会号)

    橋本 毅久, 小池 輝元, 青木 正, 土田 正則, 林 純一

    日本呼吸器外科学会雑誌   21 ( 3 )   334 - 334   2007

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.21.334_3

    CiNii Article

    researchmap

  • PS-047-3 当院における降下性壊死性縦隔炎に対する治療の検討(縦隔炎2, 第24回日本呼吸器外科学会総会号)

    小池 輝元, 土田 正則, 青木 正, 橋本 毅久, 本野 望, 佐藤 裕喜, 林 純一

    日本呼吸器外科学会雑誌   21 ( 3 )   426 - 426   2007

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.21.426_1

    CiNii Article

    researchmap

  • VD-12-2 頚胸部領域に発生した滑膜肉腫に対して前方および後方アプローチにより切除した1例(縦隔腫瘍の手術(2), 第24回日本呼吸器外科学会総会号)

    青木 正, 土田 正則, 橋本 毅久, 小池 輝元, 本野 望, 林 純一

    日本呼吸器外科学会雑誌   21 ( 3 )   353 - 353   2007

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.21.353_4

    CiNii Article

    researchmap

  • PS-050-1 自然気胸に対する胸腔鏡手術の利点と欠点(肺嚢胞性疾患2, 第24回日本呼吸器外科学会総会号)

    本野 望, 青木 正, 小池 輝元, 橋本 毅久, 土田 正則, 林 純一

    日本呼吸器外科学会雑誌   21 ( 3 )   430 - 430   2007

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.21.430_1

    CiNii Article

    researchmap

  • Ultrafiltration attenuates cardiopulmonary bypass-induced acute lung injury in a canine model of single-lung transplantation Reviewed

    Masayuki Saitoh, Masanori Tsuchida, Terumoto Koike, Koichi Satoh, Manabu Haga, Tadashi Aoki, Shin-ichi Toyabe, Jun-ichi Hayashi

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   132 ( 6 )   1447 - U28   2006.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MOSBY-ELSEVIER  

    Objective: The purpose of this study was to investigate the effects of cardiopulmonary bypass and ultrafiltration on graft function in a canine single-lung transplantation model.
    Methods: Fifteen left single-lung transplantations were done in weight-mismatched canine pairs. The animals were divided into 3 groups: group 1, in which transplantation was done without cardiopulmonary bypass; group 2, in which transplantation was done with cardiopulmonary bypass and in which the cardiopulmonary bypass flow was decreased slowly with controlled pulmonary artery pressure; and group 3, in which transplantation was done with cardiopulmonary bypass and ultrafiltration. Hemodynamic parameters and lung function were monitored for 6 hours after reperfusion. The grafts were harvested for histologic studies, myeloperoxidase assay, and real-time quantitive reverse transcription-polymerase chain reaction of mRNA encoding interleukin 6.
    Results: The hemodynamic parameters were similar among the 3 groups. In group 1 Pa-O2 and alveolar to arterial gradient for O-2 levels were excellent throughout the 6-hour observation period, but in group 2 they progressively deteriorated. However, ultrafiltration significantly (P = .02) improved the PaO2 level in group 3. On histology, interstitial edema and polynuclear cell infiltration were most marked in group 2 and significantly worse than in groups 1 and 3. Myeloperoxidase assay and real-time quantitative reverse transcription-polymerase chain reaction showed increased myeloperoxidase activity and interleukin 6 gene expression in group 2 grafts compared with group 1 grafts. Myeloperoxidase activity and interleukin 6 gene expression were suppressed with ultrafiltration.
    Conclusions: Cardiopulmonary bypass had negative effects on the graft, but ultrafiltration attenuated acute lung dysfunction by reducing the inflammatory response.

    DOI: 10.1016/j.jtcvs.2006.08.020

    Web of Science

    PubMed

    researchmap

  • 術前CTにて診断し切除したCastleman病の1例

    佐藤 裕喜, 土田 正則, 小池 輝元, 橋本 毅久, 青木 正, 林 純一

    日本胸部外科学会関東甲信越地方会要旨集   ( 140回 )   14 - 14   2006.12

     More details

    Language:Japanese   Publisher:日本胸部外科学会-関東甲信越地方会  

    researchmap

  • 臨床病期I期肺腺癌におけるCT濃度からみた術式の検討

    橋本 毅久, 土田 正則, 小池 輝元, 青木 正, 林 純一

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   54 ( Suppl. )   310 - 310   2006.9

     More details

    Language:Japanese   Publisher:シュプリンガー・ジャパン(株)  

    researchmap

  • 肺癌組織中核酸代謝酵素(TS,DPD,OPRT)の測定法別発現程度とその意義

    土田 正則, 青木 正, 橋本 毅久, 小池 輝元, 林 純一, 吉谷 克雄, 大和 靖, 小池 輝明

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   54 ( Suppl. )   436 - 436   2006.9

     More details

    Language:Japanese   Publisher:シュプリンガー・ジャパン(株)  

    researchmap

  • 体外循環下犬片肺移植における限外ろ過の酸素化能改善効果

    小池 輝元, 斉藤 正幸, 佐藤 浩一, 羽賀 学, 青木 正, 土田 正則, 林 純一

    移植   41 ( 1 )   54 - 55   2006.2

     More details

    Language:Japanese   Publisher:(一社)日本移植学会  

    researchmap

  • Analysis of the effect of surgical lung biopsy on serum KL-6 levels in patients with interstitial pneumonia: Surgical lung biopsy does not elevate serum KL-6 levels Reviewed

    Jun-ichi Narita, Takashi Hasegawa, Masanori Tsuchida, Masaki Terada, Toshinori Takada, Takehisa Hashimoto, Tadashi Aoki, Hiroki Tsukada, Ichiei Narita, Jun-ichi Hayashi, Fumitake Gejyo, Eiichi Suzuki

    INTERNAL MEDICINE   45 ( 9 )   615 - 619   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC INTERNAL MEDICINE  

    Objective It is well known that the serum level of KL-6 can be an indicator of disease activity in patients with interstitial pneumonia (IP). However, surgical lung biopsy is often required for the diagnosis of IP, although this can result in IP exacerbation.
    Methods The effect of surgical lung biopsy on the serum level of KL-6 in patients with IP was analyzed. Thirty-two cases of IP were examined in this study. There were no cases showing exacerbation of IP.
    Results The serum level of KL-6 demonstrated 1067 +/- 550 U/ml (mean +/- SD) before lung biopsy, 991 +/- 471 U/ml a day, 824 +/- 377 U/ml 4 days and 826 +/- 384 U/ml 7 days after lung biopsy. The serum KL-6 levels on the 1st, 4th, 7th day after the lung biopsy were significantly lower than that before the lung biopsy (P &lt; 0.05, P &lt; 0.01 and P &lt; 0.01, respectively). The percent decrease of the serum KL-6 levels on the 4th day (the lowest level) was dependent on the urine volume, and the analysis of the urinary levels of KL-6 showed a transient increase in urinary KL-6 excretion, suggesting that the decrease in serum KL-6 levels associated with surgical lung biopsy may be caused by this increase in urinary KL-6 excretion.
    Conclusion Surgical lung biopsy of patients with IP has little effect on the increase in serum KL-6 levels. An elevation of serum KL-6 after surgical lung biopsy may indicate exacerbation of IP.

    DOI: 10.2169/internalmedicine.45.1606

    Web of Science

    CiNii Article

    researchmap

  • A Case of Malignant Pleural Mesothelioma Detected by Pneumothorax Reviewed

    Takehisa Hashimoto, Tadashi Aoki, Masanori Tsuchida, Jun-Ichi Hayashil, Hajime Umezu, Eiju Tsuchiya

    Japanese Journal of Lung Cancer   46 ( 2 )   169 - 170   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2482/haigan.46.169

    Scopus

    researchmap

  • P-044 術前合併症を有する肺癌手術における病態別の合併症頻度と周術期管理の検討(一般示説07 肺癌合併疾患,世界をリードする呼吸器外科医に!,第23回日本呼吸器外科学会総会)

    土田 正則, 青木 正, 橋本 毅久, 篠原 博彦, 斉藤 正幸, 岡田 英, 小池 輝元, 保坂 靖子, 林 純一

    日本呼吸器外科学会雑誌   20 ( 3 )   851 - 851   2006

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.20.851_4

    CiNii Article

    researchmap

  • OP3-1 体外循環下犬片肺移植における限外ろ過の虚血再灌流障害軽減効果(一般口演03 基礎研究,世界をリードする呼吸器外科医に!,第23回日本呼吸器外科学会総会)

    小池 輝元, 土田 正則, 青木 正, 橋本 毅久, 佐藤 浩一, 篠原 博彦, 斉藤 正幸, 岡田 英, 保坂 靖子, 林 純一

    日本呼吸器外科学会雑誌   20 ( 3 )   807 - 807   2006

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.20.807_4

    CiNii Article

    researchmap

  • Ultrasmall pulmonary opacities on multidetector-row high-resolution computed tomography - A prospective radiologic-pathologic examination Reviewed

    H Ishikawa, N Koizumi, T Morita, Y Tani, M Tsuchida, H Umezu, M Naito, K Sasai

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY   29 ( 5 )   621 - 625   2005.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    Objective: To clarify the pathologic findings of ultrasmall pulmonary opacities (5 mm or smaller in diameter) found on multidetector-row high-resolution computed tomography (MD-HRCT).
    Methods: Ten lobes in 10 patients were included in this study. Each lobe had a primary lung tumor and was removed surgically. Two thoracic radiologists noted any tiny nonlinear opacity on preoperative MD-HRCT films (1.25-mm thickness) covering the whole lobe. Pathologic findings of detected opacities were evaluated macroscopically and microscopically.
    Results: Among 139 ultrasmall opacities 5 mm or smaller in diameter, 94 corresponded to normal anatomic structures (partial volume averaging or motion artifact), 36 corresponded to pathologic abnormalities, and 9 were unidentified. Histologic diagnoses of 36 pathologic abnormalities were inflammatory lesions (n = 16), intrapulmonary lymph nodes (IPLN; n = 7), atypical adenomatous hyperplasia (AAH; n = 7), bronchioloalveolar carcinoma (BAC; n = 5), and another neoplastic lesion (n = 1).
    Conclusion: Tiny pulmonary lesions, such as AAHs, BACs, and IPLNs, were identified among ultrasmall opacities found on MD-HRCT.

    DOI: 10.1097/01.rct.0000172672.09564.8c

    Web of Science

    PubMed

    researchmap

  • 初期研修医にも気胸の術者は可能か?

    青木 正, 土田 正則, 橋本 毅久, 篠原 博彦, 斉藤 正幸, 岡田 英, 小池 輝元, 林 純一

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   53 ( Suppl.II )   566 - 566   2005.9

     More details

    Language:Japanese   Publisher:シュプリンガー・ジャパン(株)  

    researchmap

  • 犬左片肺移植における体外循環使用の影響の検討

    斉藤 正幸, 土田 正則, 青木 正, 橋本 毅久, 佐藤 浩一, 篠原 博彦, 岡田 英, 小池 輝元, 林 純一

    移植   40 ( 1 )   82 - 83   2005.2

     More details

    Language:Japanese   Publisher:(一社)日本移植学会  

    researchmap

  • Neutrophil elastase inhibitor ameliorates reperfusion injury in a canine model of lung transplantation Reviewed

    T Aoki, M Tsuchida, M Takekubo, M Saito, K Sato, J Hayashi

    EUROPEAN SURGICAL RESEARCH   37 ( 5 )   274 - 280   2005

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:KARGER  

    Background: We investigated the effects of neutrophil elastase inhibitor ONO-5046 Na on lung ischemia-reperfusion injury in a canine model of single lung transplantation. Methods: 24 mongrel dogs, 12 donors and 12 recipients, were used for single lung transplantation. Lung grafts were preserved for 18 h by cold ischemia then transplanted into the left thoracic cavity of recipients. In 6 recipients (ONO group), a bolus of ONO-5046 Na (10 mg/kg) was introduced before reperfusion and followed by continuous infusion (10 mg/kg/h). The remaining 6 recipients (control group) did not receive ONO-5046 Na and thus served as controls. We evaluated lung function and respiratory parameters over 240 min. Results: The total cell number in bronchoalveolar lavage fluid increased significantly in the control group in comparison to that in the ONO group. Histologic scores after 4 h of reperfusion and myeloperoxidase activity were significantly lower in the ONO group than in the control group. Conclusion: Neutrophil elastase inhibitor ONO-5046 Na may be useful in ameliorating lung reperfusion injury after transplantation. Copyright (C) 2005 S. Karger AG, Basel.

    DOI: 10.1159/000089234

    Web of Science

    researchmap

  • 肺癌患者血清におけるp16癌抑制遺伝子プロモーター領域メチル化の検出と再発予後の検討(肺癌 (9), 第22回日本呼吸器外科学会総会)

    橋本 毅久, 小池 輝元, 岡田 英, 斎藤 正幸, 篠原 博彦, 渡辺 健寛, 青木 正, 土田 正則, 林 純一

    日本呼吸器外科学会雑誌   19 ( 3 )   430 - 430   2005

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.19.430_3

    CiNii Article

    researchmap

  • 犬左片肺移植における体外循環使用の影響の検討(気道再建/肺移植, 第22回日本呼吸器外科学会総会)

    斉藤 正幸, 土田 正則, 青木 正, 橋本 毅久, 佐藤 浩一, 小池 輝元, 林 純一

    日本呼吸器外科学会雑誌   19 ( 3 )   475 - 475   2005

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.19.475_2

    CiNii Article

    researchmap

  • 肺癌に対する縮小手術の功と罪 スリガラス陰影(GGO)を主体とする肺癌に対する積極的縮小手術の成績と問題点

    土田 正則, 青木 正, 橋本 毅久, 篠原 博彦, 斎藤 正幸, 岡田 英, 小池 輝元, 林 純一

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   52 ( Suppl. )   196 - 196   2004.9

     More details

    Language:Japanese   Publisher:シュプリンガー・ジャパン(株)  

    researchmap

  • MOS 36-Item Short-Form Health Surveyを用いた肺癌術後QOLの評価 胸腔鏡手術と開胸手術の比較

    青木 正, 土田 正則, 橋本 毅久, 篠原 博彦, 斉藤 正幸, 岡田 英, 小池 輝元, 林 純一

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   52 ( Suppl. )   492 - 492   2004.9

     More details

    Language:Japanese   Publisher:シュプリンガー・ジャパン(株)  

    researchmap

  • Electorporation法を用いたnaked DNA(IL-10)遺伝子導入による閉塞性細気管支病変予防効果

    土田 正則, 青木 正, 橋本 毅久, 篠原 博彦, 竹久保 賢, 斎藤 正幸, 小池 輝元, 林 純一

    移植   39 ( 総会臨時 )   251 - 251   2004.7

     More details

    Language:Japanese   Publisher:(一社)日本移植学会  

    researchmap

  • Electroporation法を用いたIL-10遺伝子導入による閉塞性気道病変の予防効果

    土田 正則, 青木 正, 橋本 毅久, 竹久保 賢, 篠原 博彦, 斎藤 正幸, 岡田 英, 小池 輝元, 林 純一

    移植   39 ( 2 )   206 - 207   2004.4

     More details

    Language:Japanese   Publisher:(一社)日本移植学会  

    researchmap

  • 頭蓋骨血管肉腫肺転移の破裂により生じた気胸に対する一手術例

    岡本 竹司, 橋本 毅久, 土田 正則, 青木 正, 斎藤 正幸, 小池 輝元, 林 純一

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   52 ( Suppl. )   77 - 77   2004.3

     More details

    Language:Japanese   Publisher:シュプリンガー・ジャパン(株)  

    researchmap

  • 【末梢型小型肺癌の手術】画像上すりガラス状陰影を呈した末梢型小型肺癌に対する縮小手術

    土田 正則, 青木 正, 橋本 毅久, 篠原 博彦, 斎藤 正幸, 岡田 英, 小池 輝元, 林 純一

    胸部外科   57 ( 1 )   38 - 43   2004.1

     More details

    Language:Japanese   Publisher:(株)南江堂  

    すりガラス状陰影(GGO)を主体とする細気管支肺胞型腺癌に対する縮小手術の成績とその妥当性を検討した.1996年10月から2003年4月までに細気管支肺胞型腺癌の疑いにて縮小手術を施行した症例のうち,CT上腫瘍径20mm以下かつ腫瘍全体に対するGGO領域の比率が50%以上の58例を対象とした.58例中48例に部分切除,2例に区域切除が行われ,8例は浸潤性増殖や高度線維化などにより肺葉切除へ移行した.術中迅速病理診断と術後病理標本の対比では56例の結果は一致したが2例は過小評価であった.また,術後合併症は肺胞瘻1例を認めたのみであり,術後2〜80ヵ月間の観察では肺葉切除に移行した症例を含め57例が無再発生存中である.HRCTと病理所見を野口分類で対比するとtypeA+Bでは腫瘍最大径が有意に小さく,高濃度部分や線状陰影の有無についても有意に少なかった.線状陰影のない10mm以下の病変では縮小手術の対象と考えられた

    researchmap

    Other Link: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J00349&link_issn=&doc_id=20040416170010&doc_link_id=1390282763052636160&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390282763052636160&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_2.gif

  • Registration of resected lung cancer in Niigata Prefecture Reviewed

    Takehiro Watanabe, Tatsuhiko Hirono, Teruaki Koike, Masanori Tsuchida, Kenichi Togashi, Kenji Nakayama, Masatomo Yazawa, Tsuyoshi Koyashiki, Hiroshi Kanazawa

    Japanese Journal of Thoracic and Cardiovascular Surgery   52 ( 5 )   225 - 230   2004

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association for Thoracic Surgery  

    Objectives: Our registration of surgically treated lung cancer patients in Niigata Prefecture began in 2001. The purpose of this study was to identify the characteristics of patients and surgical treatment of lung cancer. Methods: All patients who underwent resection for lung cancer in Niigata Prefecture from January 2001 to December 2002 were eligible for registration. A total of 31 medical data for each patient were registered. Results: During the 2-year period, 1,211 patients were registered. A total of 605 cases (50%) were detected by mass screening, and 874 cases (72%) were diagnosed preoperatively. There were 718 (59%) c-stage IA cases and 317 (26%) c-stage IB cases. The most common operative procedure was lobectomy
    850 patients underwent single lobectomy. Limited resection was performed in 301 patients (25%), and video-assisted thoracoscopic surgery in 193 (16%). The most common histological type was adenocarcinoma in 860 cases (71%), followed by squamous cell carcinoma in 273 (23%). Pathologic staging yielded stage IA in 635 cases (52%) and stage IB in 262 (22%). Conclusions: The results of our registration demonstrate a very high ratio of surgically treated stage IA cases in Niigata Prefecture and that limited resection was performed in many patients. Accumulation of these data will reveal the characteristics of lung cancer surgically treated in Niigata Prefecture and will provide a basis for determining the future course of surgical treatment for lung cancer. Registration is continuing, and it will provide new and useful information about lung cancer, eventually including 5-year survival data.

    DOI: 10.1007/s11748-004-0115-y

    Scopus

    PubMed

    researchmap

  • P-421 遺伝子異常を利用した非小細胞肺癌微小転移の検出(基礎研究3)(一般示説43)

    橋本 毅久, 小池 輝元, 岡田 英, 斎藤 正幸, 篠原 博彦, 渡辺 健寛, 青木 正, 土田 正則, 林 純一, 土屋 永寿

    日本呼吸器外科学会雑誌   18 ( 3 )   442 - 442   2004

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器外科学会  

    DOI: 10.2995/jacsurg.18.442_1

    CiNii Article

    researchmap

  • 末梢小型肺癌 治療法の選択 高濃度部分を有さないpure GGA病変に対する診断・治療方針の検討

    土田 正則, 青木 正, 橋本 毅久, 篠原 博彦, 斎藤 正幸, 岡田 央, 小池 輝元, 林 純一

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   51 ( Suppl. )   165 - 165   2003.10

     More details

    Language:Japanese   Publisher:シュプリンガー・ジャパン(株)  

    researchmap

  • 集学的治療が奏効した胸腺癌の一例(共著) Reviewed

    佐野博繁, 渡部聡, 田中純太, 松山弘紀, 平田明, 広瀬貴之, 田中洋史, 各務博, 吉澤弘久, 下条文武, 渡辺マヤ, 小池輝元, 橋本毅久, 土田正則, 林純一, 笹本龍太, 笹井啓資

    新潟医学会雑誌   118 ( 7 )   347 - 354   2003.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    researchmap

  • Surgical strategy for clinical stage I non-small cell lung cancer in octogenarians Reviewed

    T Aoki, M Tsuchida, T Watanabe, T Hashimoto, T Koike, T Hirono, JI Hayashi

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   23 ( 4 )   446 - 450   2003.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Objective: The purpose of this study was to determine whether lobectomy without radical systematic mediastinal lymphadenectomy (LA) is a satisfactory alternative surgical treatment for octogenarians with clinical stage I non-small cell lung cancer (NSCLC). Methods: From April 1985 through December 2001, 49 patients aged 80 years and older who underwent surgical treatment for clinical stage I NSCLC were reviewed. Lobectomy without radical systematic mediastinal LA was performed for 27 patients (LA0 group) and lobectomy with radical systematic mediastinal LA was performed for 22 patients (LA group). Results: The mortality rate was 0% in the LA0 group and 4.5% in the LA group. Five-year survival rate according to the type of surgery was 44.8% in the LA0 group and 55.5% in the LA group, a difference that was not significant (P = 0.88). Although there was no significant statistical difference, postoperative pulmonary complication was more frequent in the LA group than in the LA0 group (32% in the LA group versus 11% in the LA0 group P = 0.07). Five-year survival rates according to serum carcinoembryonic antigen (CEA) levels were 0% for patients with elevated CEA levels (n = 9) and 56.5% for patients with normal CEA levels (n = 40) (P &lt; 0.01). Conclusion: Lobectomy without radical systematic mediastinal LA appears to be a satisfactory surgical procedure for octogenarians with clinical stage I NSCLC. However, mediastinoscopy is necessary in such octogenarians if their serum CEA level is elevated so that the precise clinical stage can be determined and an accurate prognosis can be given. (C) 2003 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S1010-7940(03)00014-9

    Web of Science

    PubMed

    researchmap

  • Microcystic variant of localized malignant mesothelioma accompanying an adenomatoid tumor-like lesion Reviewed

    H Umezu, K Kuwata, Y Ebe, T Yamamoto, M Naito, Y Yamato, T Ishiyama, M Tsuchida, M Okuizumi, H Ishikawa, N Koizumi

    PATHOLOGY INTERNATIONAL   52 ( 5-6 )   416 - 422   2002.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BLACKWELL PUBLISHING ASIA  

    The case of a 70-year-old man with a hitherto undescribed pleural mesothelioma is reported. The tumor was localized in the left lung apex and had invaded the parietal pleura. Histologically, the tumor was characterized by a proliferation of epithelioid cells and the formation of microcysts. The tumor cells were positive for calretinin and vimentin, and possessed abundant microvilli, indicating a mesothelial cell origin for the tumor. A high Ki-67 index and mitotic index, and the recurrence of the tumor after surgery, indicated malignancy. Based on the evidence, we propose that the tumor is a microcystic variant of a localized malignant mesothelioma.

    DOI: 10.1046/j.1440-1827.2002.01357.x

    Web of Science

    PubMed

    CiNii Article

    researchmap

  • 大静脈の再建を要した悪性腫瘍症例の検討

    名村 理, 島田 晃治, 竹久保 賢, 中山 卓, 榛澤 和彦, 青木 正, 土田 正則, 北村 昌也, 林 純一

    日本血管外科学会雑誌   11 ( 2 )   217 - 217   2002.4

     More details

    Language:Japanese   Publisher:(NPO)日本血管外科学会  

    researchmap

  • 間質性肺炎症例の肺生検時における経時的血清KL-6値の変動の検討(第25回日本気管支学会総会)

    成田 淳一, 小屋 俊之, 長谷川 隆志, 森山 寛史, 土田 正則, 青木 正, 橋本 毅久, 鈴木 栄一, 林 純一, 下条 文武

    気管支学   24 ( 3 )   206 - 206   2002

     More details

    Language:Japanese   Publisher:特定非営利活動法人 日本呼吸器内視鏡学会  

    DOI: 10.18907/jjsre.24.3_206_1

    CiNii Article

    researchmap

  • Segmental bronchial atresia of the left upper lobe treated with segmental resection under video-assisted thoracic surgery Reviewed

    M Tsuchida, K Aoki, T Hashimoto, Y Yamato, J Hayashi

    SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES   11 ( 3 )   217 - 220   2001.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    We report our experience of segmental bronchial atresia managed with segmental resection under video-assisted thoracic surgery. A 23-year-old woman reporting a cough, dyspnea, and back pain underwent segmental resection in which a stapling device was used under video-assisted thoracic surgery. Her postoperative course was uneventful with minimal pain and a disappearance of preoperative symptoms after surgery. Once an accurate preoperative diagnosis can be established, video-assisted thoracic segmentectomy together with the use of a stapling device is considered to be feasible.

    Web of Science

    researchmap

  • Early results of a prospective study of limited resection for bronchioloalveolar adenocarcinoma of the lung Reviewed

    Y Yamato, M Tsuchida, T Watanabe, T Aoki, N Koizumi, H Umezu, J Hayashi

    ANNALS OF THORACIC SURGERY   71 ( 3 )   971 - 974   2001.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Background. We reported that bronchioloalveolar adenocarcinoma (BAC) without active fibroblastic proliferation of the lung had no lymph node and pulmonary metastasis and had a favorable prognosis. However, there has been no prospective trial regarding limited pulmonary resection for this type of BAG. The purpose of this study is to confirm the effectiveness of limited resection for histologically confirmed BAC without active fibroblastic proliferation.
    Methods. From 1996 through 1999, 42 patients who had small peripheral lung tumors (less than or equal to 20 mm), suspected of being BAG, were enrolled in this trial. The patient population consisted of 24 men and 18 women with a mean age of 58.4 years. Limited resection was completed when BAG, without both active fibroblastic proliferation and lymph node metastasis, was con-firmed histalogically by intraoperative pathologic examination.
    Results. Limited resection was completed in 36 patients, wedge resection in 34, and segmentectomy in 2 patients. In 6 patients, the procedure was converted into lobectomy because of pathologic invasive sign in 3, active fibroblastic proliferation in 1, and for other reasons in 2 patients. All patients have been followed for a median follow-up period of 30 months and are alive without sign of recurrence.
    Conclusions. Our early results indicate that limited resection may be an acceptable alternative to lobectomy for histologically confirmed BAC without active fibroblastic proliferation (C) 2001 by The Society of Thoracic Surgeons.

    Web of Science

    researchmap

  • Pulmonary complications after surgical treatment of lung cancer in octogenarians Reviewed

    T Aoki, Y Yamato, M Tsuchida, T Watanabe, J Hayashi, T Hirono

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   18 ( 6 )   662 - 665   2000.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Objective: The purpose of this study was to analyze the risks associated with pulmonary resection for primary non-small cell lung cancer in octogenarians to help better management in these patients. Methods: We reviewed the outcome in our 35 patients aged 80 years and older who underwent pulmonary resection between 1981 and 1998. Results: The 5-year survival rate was 39.8%. The operative mortality rate was 0% and the morbidity 60%. There were ten major pulmonary complications, including respiratory insufficiency following bacterial pneumonia and sputum retention. Preoperative arterial pO(2) was significantly lower, A-aDO(2) was significantly higher, and operation time were significantly longer in patients with pulmonary complications after surgical treatment than in patients without complications (P &lt; 0.05), Conclusions: Surgical treatment was not contraindicated for octogenarians with lung cancer. However, a relatively preoperative low arterial pO(2), high A-aDO(2), and long operation time may be risk factors for postoperative pulmonary complications in such patients. Surgeons must assess the preoperative data prudently to determine appropriate surgical strategy. (C) 2000 Elsevier Science B.V. All rights reserved.

    Web of Science

    researchmap

  • Changes in graft flow pattern from the descending aorta due to intraaortic balloon pump Reviewed

    M Tsuchida, Y Yamato, T Watanabe, H Ohzeki, JI Hayashi

    ANNALS OF THORACIC SURGERY   70 ( 3 )   980 - 982   2000.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    During surgery for lung cancer in a patient who had undergone coronary artery bypass grafting through the descending aorta by left thoracotomy, we measured graft bypass blood now from the descending aorta under intraaortic balloon pump (IABP) assistance. Under IABP assistance, the diastolic waveform changed to a spiky pattern with a sharp drop in blood flow of approximately 16% compared to that without LABP assistance. We report changes in graft flow pattern during IABP assistance when the graft is placed from the descending aorta. (Ann Thorac Surg 2000;70:980-2) (C) 2000 by The Society of Thoracic Surgeons.

    Web of Science

    researchmap

  • A simple and sensitive quantitative method for determining xenoreactive antibody titers in the mouse-to-rat cardiac transplantation model Reviewed

    R Haga, H Hirahara, M Tsuchida, T Watanabe, M Takekubo, J Hayashi

    TRANSPLANTATION PROCEEDINGS   32 ( 5 )   862 - 863   2000.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Web of Science

    researchmap

  • Successful tracheal transplantation using cryopreserved allografts in a rat model Reviewed

    T Aoki, Y Yamato, M Tsuchida, T Souma, K Yoshiya, T Watanabe, J Hayashi

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   16 ( 2 )   169 - 173   1999.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Objectives: The purpose of this study was to determine the appropriate cryopreservation period of tracheal allografts based on morphological and immunological findings and to test the possibility of tracheal transplantation in rats using cryopreserved allografts without immunosuppression. Methods: Morphological and immunological studies were performed to compare the differences between non-cryopreserved grafts and cryopreserved grafts. Orthotopic tracheal transplantation using cryopreserved allografts, non-cryopreserved allografts, and non-cryopreserved autografts was performed and the rejection score of each group was evaluated. Results: Epithelial cells were lost when the grafts were cryopreserved for more than 20 days. Immunohistochemical staining of the trachea revealed that the MHC classII antigen was expressed on normal epithelium. These findings suggest that cryopreservation for more than 20 days decreased the antigeneicity of allografts because of epithelial desquamation. All rats that received allografts cryopreserved for more than 20 days survived until the scheduled sacrifice day. Microscopically, cryopreserved allografts that had been preserved for more than 20 days had a significantly lower rejection score than that of non-cryopreserved allografts (P &lt; 0.05). Conclusions: We conclude that the appropriate period for cryopreservation of allografts would be 20 days or more, because cryopreservation for more than 20 days depleted epithelium, which possessed the MHC classII antigen. Therefore, a longer period of cryopreservation decreases the antigeneicity of allografts. Rat tracheal transplantations using cryopreserved allografts is possible without immunosuppression when the grafts have been cryopreserved for more than 20 days. (C) 1999 Elsevier Science B.V. All rights reserved.

    Web of Science

    researchmap

  • Characterization of CD4(-)CD8(-) T cell receptor alpha beta(+) T cells appearing in the subarachnoid space of rats with autoimmune encephalomyelitis Reviewed

    Y Matsumoto, S Abe, M Tsuchida, H Hirahara, T Abo, T Shin, N Tanuma, T Kojima, Y Ishihara

    EUROPEAN JOURNAL OF IMMUNOLOGY   26 ( 6 )   1328 - 1334   1996.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:VCH PUBLISHERS INC  

    Inflammation of the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE) starts in the subarachnoid space (SAS) and spreads later to the adjacent CNS parenchyma. To characterize the nature of lesion-forming T cells in situ in more detail, T cells were isolated from the SAS and their surface phenotype and the nucleotide sequence of the junctional region of the T cell receptor (TCR) was determined and compared with those of the lymph node (LN) and spinal cord (SC) T cells. Characteristically, more than 70% of SAS TCR alpha beta(+) T cells isolated at the early stage of EAE lacked both CD4 and CD8 molecules, whereas those from LN and SC were either CD4(+) or CD8(+). Analysis of nucleotide sequences of the junctional region of TCR revealed that T cells bearing a sequence identical to that for encephalitogenic T cell clones were found in both SAS and SC. Furthermore, purified CD4(-)CD8(-) T cells expressed CD4 molecules after culture. At the same time, these T cells acquired reactivity to myelin basic protein and induced passive EAE in naive animals after adoptive transfer. Our results suggest that CD4(-)CD8(-) T cells in the SAS are precursors of lesion-forming T cells in the SC and that phenotype switching takes place during the process of T cell infiltration into the CNS parenchyma. The double-negative nature of these T cells may explain an escape of encephalitogenic T cells from negative selection in T cell differentiation.

    Web of Science

    researchmap

  • T-CELL RECEPTOR PEPTIDE THERAPY FOR AUTOIMMUNE ENCEPHALOMYELITIS - STRONGER IMMUNIZATION IS NECESSARY FOR EFFECTIVE VACCINATION Reviewed

    Y MATSUMOTO, M TSUCHIDA, H HANAWA, T ABO

    CELLULAR IMMUNOLOGY   153 ( 2 )   468 - 478   1994.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS  

    Web of Science

    researchmap

  • GLUCOCORTICOID INDEPENDENCE OF ACUTE THYMIC INVOLUTION INDUCED BY LYMPHOTOXIN AND ESTROGEN Reviewed

    H HIRAHARA, M OGAWA, M KIMURA, T IIAI, M TSUCHIDA, H HANAWA, H WATANABE, T ABO

    CELLULAR IMMUNOLOGY   153 ( 2 )   401 - 411   1994.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS  

    Web of Science

    researchmap

  • CD5+ B-CELLS IN THE THYMUS OF PATIENTS WITH MYASTHENIA-GRAVIS Reviewed

    M TSUCHIDA, S HASHIMOTO, T ABO, H MIYAMURA, T HIRONO, S EGUCHI

    BIOMEDICAL RESEARCH-TOKYO   14 ( 1 )   19 - 25   1993.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BIOMED RES FOUND  

    CD5+ B and coexisting T cells in the thymus of control individuals and patients with myasthenia gravis (MG) were analyzed with monoclonal antibodies in conjunction with a two-color immunofluorescence test. Similar to findings in a mouse study, we found that, in 9 control subjects, CD5+ B cells (mean: 1.5%) were the predominant subset (approximately 80%) among thymic B cells (1.8% of thymocytes). In patients with MG (n=6), both the proportion of CD5+ B (3.2%) and total B cells (7.8%) in the thymus were significantly elevated (P=0.005). In this regard, the ratio of CD5+ B / total B cells in MG (45%) was somewhat lower than in control subjects. This raises the possibility that some CD5- B cells are a CD5-sister population of CD5+ B cells in MG, as has been shown in mouse studies. Coexisting thymic T cells in MG were somewhat different (e.g., in exhibiting a reduction in the double-positive CD4+ CD8+ population) from those in controls. The reason for this finding is discussed with reference to recent findings of medullary T cells in the thymus. The present results might be intimately related to the pathogenesis of MG.

    Web of Science

    researchmap

▶ display all

MISC

▶ display all

Awards

  • がん集学的治療研究財団

    1999  

     More details

    Country:Japan

    researchmap

  • 上原記念生命科学財団海外留学助成リサーチフェローシップ

    1994  

     More details

    Country:Japan

    researchmap

  • 新潟県医師会研究助成

    1993  

     More details

    Country:Japan

    researchmap

  • 新潟大学医学部塚田医学助成

    1992  

     More details

    Country:Japan

    researchmap

Research Projects

  • Surgery of lung cancer

      More details

    Grant type:Competitive

    researchmap

  • Induction of spectific tolerance to allograft

      More details

    Grant type:Competitive

    researchmap

  • Change of immunclogical response during and after cardiopulmonary bypass

      More details

    Grant type:Competitive

    researchmap

  • 肺癌の外科治療

      More details

    Grant type:Competitive

    researchmap

  • 同種移植における免疫寛容誘導の研究

      More details

    Grant type:Competitive

    researchmap

  • 体外循環に伴う免疫反応の変化

      More details

    Grant type:Competitive

    researchmap

▶ display all

 

Teaching Experience

  • 臨床医学講義(集中)

    2022
    -
    2021
    Institution name:新潟大学

  • 臨床実習IA

    2021
    -
    2020
    Institution name:新潟大学

  • 臨床実習ⅠC

    2020
    Institution name:新潟大学

  • 臨床実習ⅠB

    2020
    Institution name:新潟大学

  • 臨床実習ⅡB(clinical clerkship)

    2019
    -
    2020
    Institution name:新潟大学

  • 臨床医学講義(集中)

    2018
    -
    2021
    Institution name:新潟大学

  • 臓器別講義・演習Ⅰ

    2018
    -
    2020
    Institution name:新潟大学

  • 臓器別講義・演習Ⅲ

    2018
    -
    2020
    Institution name:新潟大学

  • 臓器別講義・演習Ⅱ

    2018
    -
    2020
    Institution name:新潟大学

  • 臨床実習II(clinical clerkship)

    2018
    Institution name:新潟大学

  • 臨床実習ⅡA(clinical clerkship)

    2018
    Institution name:新潟大学

  • 日本事情自然系B

    2007
    Institution name:新潟大学

▶ display all