Updated on 2026/03/10

写真a

 
SUDA Takeshi
 
Organization
University Medical and Dental Hospital Uonuma Institute of Community Medicine Specially Appointed Professor
Title
Specially Appointed Professor
External link

Degree

  • 医学博士 ( 1996.3   新潟大学 )

Research Interests

  • 遺伝子治療

  • 消化器内科学

  • 肝臓病学

Research Areas

  • Life Science / Gastroenterology

  • Life Science / Pharmaceutical chemistry and drug development sciences  / 遺伝子治療

Research History (researchmap)

  • Niigata University   University Medical and Dental Hospital Uonuma Institute of Community Medicine   Specially Appointed Professor

    2015.4

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  • Niigata University   Graduate School of Medical and Dental Sciences Biomedical Sciences   Lecturer

    2012.11

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  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control   Lecturer

    2012.11

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  • Niigata University   University Medical and Dental Hospital Gastroenterology   Lecturer

    2012.11 - 2015.3

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  • Niigata University   University Medical and Dental Hospital Internal Medicine III   Lecturer

    2011.9 - 2012.11

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  • Niigata University   Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Molecular Genetics   Assistant Professor

    2007.4 - 2011.8

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  • Niigata University   Graduate School of Medical and Dental Sciences   Assistant

    2003.2 - 2007.3

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Research History

  • Niigata University   University Medical and Dental Hospital UONUMA CHIIKI IRYO KYOIKU CENTER JUNBISHITU   Specially Appointed Professor

    2015.4

  • Niigata University   University Medical and Dental Hospital Gastroenterology   Lecturer

    2012.11 - 2015.3

  • Niigata University   Graduate School of Medical and Dental Sciences Biomedical Sciences   Lecturer

    2012.11 - 2015.3

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control   Lecturer

    2012.11 - 2015.3

  • Niigata University   University Medical and Dental Hospital Internal Medicine III   Lecturer

    2011.9 - 2012.11

  • Niigata University   Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Molecular Genetics   Assistant Professor

    2007.4 - 2011.8

  • Niigata University   Graduate School of Medical and Dental Sciences   Research Assistant

    2003.2 - 2007.3

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Education

  • Niigata University   Graduate School, Division of Medicine

    - 1996.3

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    Country： Japan

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Professional Memberships

  • The Japanese Society of Gastroenterology

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  • The Japanese Society of Hepatology

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  • The Japanese Society of Internal Medicine

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  • American Society of Gene and Cell Therapy

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  • Liver Cancer Study Group of Japan

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  • Japan Society of Gene and Cell Therapy

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  • The Japanese Cancer Association

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  • The Japan Society for Portal Hypertension

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  • Japan Gastroenterological Endoscopy Society

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Committee Memberships

  • 日本消化器病学会   本部評議員  

    2014.1 - 2018   

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    Committee type：Academic society

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  • 日本肝臓学会   評議員  

    2014.1 - 2018   

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    Committee type：Academic society

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Studying abroad experiences

  • University of Pittsburgh   Research associate

    2004.10 - 2007.9

 

Papers

  • A型肝炎の薬剤開発 現状と将来

    神田 達郎, 佐々木 玲奈, 上村 博輝, 阿部 寛幸, 水戸 將貴, 杉田 萌乃, 荒生 祥尚, 阿部 聡司, 坂牧 僚, 林 和直, 横尾 健, 上村 顕也, 須田 剛士, 寺井 崇二

    肝臓   66 ( Suppl.1 )   A362 - A362   2025.4

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    Language：Japanese   Publisher：(一社)日本肝臓学会  

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  • Liver lobe-specific hydrodynamic gene delivery to baboons: A preclinical trial for hemophilia gene therapy. International journal

    Kenya Kamimura, Tsutomu Kanefuji, Takeshi Suda, Takeshi Yokoo, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu

    Molecular therapy. Nucleic acids   32   903 - 913   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    Hydrodynamics-based gene transfer has been successfully employed for in vivo gene delivery to the liver of small animals by tail vein injection and of large animals using a computer-assisted and image-guided protocol. In an effort to develop a hydrodynamic gene delivery procedure clinically applicable for gene therapy, we have evaluated the safety and effectiveness of a lobe-specific hydrodynamic delivery procedure for hepatic gene delivery in baboons. Reporter plasmid was used to assess the gene delivery efficiency of the lobe-specific hydrodynamic gene delivery, and plasmid-carrying human factor IX gene was used to examine the pattern of long-term gene expression. The results demonstrated liver lobe-specific gene delivery, therapeutic levels of human factor IX gene expression lasting for >100 days, and the efficacy of repeated hydrodynamic gene delivery into the same liver lobes. Other than a transient increase in blood concentration of liver enzymes right after the injection, no significant adverse events were observed in animals during the study period. The results obtained from this first non-human primate study support the clinical applicability of the procedure for lobe-specific hydrodynamic gene delivery to liver.

    DOI： 10.1016/j.omtn.2023.05.018

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  • Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances. International journal

    Takeshi Suda, Takeshi Yokoo, Tsutomu Kanefuji, Kenya Kamimura, Guisheng Zhang, Dexi Liu

    Pharmaceutics   15 ( 4 )   2023.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    The principle of hydrodynamic delivery was initially used to develop a method for the delivery of plasmids into mouse hepatocytes through tail vein injection and has been expanded for use in the delivery of various biologically active materials to cells in various organs in a variety of animal species through systemic or local injection, resulting in significant advances in new applications and technological development. The development of regional hydrodynamic delivery directly supports successful gene delivery in large animals, including humans. This review summarizes the fundamentals of hydrodynamic delivery and the progress that has been made in its application. Recent progress in this field offers tantalizing prospects for the development of a new generation of technologies for broader application of hydrodynamic delivery.

    DOI： 10.3390/pharmaceutics15041111

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  • Long-term survival of 11 years with multidisciplinary therapy for hepatocellular carcinoma metastasis to the ovary and peritoneum: a case report.

    Satoko Motegi, Takeshi Yokoo, Ryosuke Nozawa, Rie Azumi, Yuzo Kawata, Kohei Ogawa, Toru Setsu, Ken-Ichi Mizuno, Koji Nishino, Hajime Umezu, Hirokazu Kawai, Takeshi Suda, Shuji Terai

    Clinical journal of gastroenterology   14 ( 4 )   1211 - 1220   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    We herein report a rare case of HCC metastases to the ovary and peritoneum in a 61-year-old female patient who has achieved 11-year survival with multidisciplinary therapy. The patient was diagnosed with HCC during balloon angioplasty performed for Budd-Chiari syndrome in 1994 and underwent partial hepatectomy twice. Five years after the second hepatectomy, allochronic recurrence of a single nodule detected in S8 was treated by radiofrequency ablation, followed by percutaneous ethanol injection therapy and stereotactic body radiotherapy. However, her α-fetoprotein level rose to 1862 ng/mL within one year and computed tomography revealed a large pelvic tumor suggesting HCC metastasis to the ovary. The subsequent laparotomy revealed one 11-cm left ovarian tumor, one small right ovarian nodule, and numerous peritoneal nodules. Bilateral salpingo-oophorectomy and peritoneal resection of as many nodules as possible were performed. Combination therapy with intravenous 5-fluorouracil plus cisplatin and ramucirumab monotherapy effectively suppressed tumor progression with maintenance of hepatic functional reserve, and she has achieved long-term survival of 11 years, illustrating that multidisciplinary therapy with favorable hepatic functional reserve maintenance can contribute to long-term survival in HCC with extrahepatic spread.

    DOI： 10.1007/s12328-021-01434-2

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  • Suppression of Noncoding RNAs as Shared Early Genetic Events in Multistep Hepatocarcinogenesis. International journal

    Takeshi Suda, Seiichi Yoshikawa, Tsutomu Kanefuji, Satoshi Abe, Takahiro Hoshi, Shinichi Morita, Kazuyoshi Yagi, Shuji Terai

    Hepatology (Baltimore, Md.)   2021.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/hep.32077

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  • A Superinfection of Salmonella typhi and Hepatitis E Virus Causes Biphasic Acute Hepatitis

    Takeshi Suda, Ryo Iguchi, Takaaki Ishiyama, Tsutomu Kanefuji, Takahiro Hoshi, Satoshi Abe, Shinichi Morita, Kazuyoshi Yagi

    Internal Medicine   60 ( 11 )   1717 - 1722   2021.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Internal Medicine  

    DOI： 10.2169/internalmedicine.6458-20

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  • Adipose most abundant 2 protein is a predictive marker for cisplatin sensitivity in cancers. International journal

    Kenya Kamimura, Takeshi Suda, Yasuo Fukuhara, Shujiro Okuda, Yu Watanabe, Takeshi Yokoo, Akihiko Osaki, Nobuo Waguri, Toru Ishikawa, Toshihiro Sato, Yutaka Aoyagi, Masaaki Takamura, Toshifumi Wakai, Shuji Terai

    Scientific reports   11 ( 1 )   6255 - 6255   2021.3

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    Cisplatin (CDDP) is one of the chemotherapeutic drugs being used to treat various cancers. Although effective in many cases, as high doses of CDDP cause cytotoxic effects that may worsen patients' condition, therefore, a marker of sensitivity to CDDP is necessary to enhance the safety and efficiency of CDDP administration. This study focused on adipose most abundant 2 (APM2) to examine its potential as a marker of CDDP sensitivity. The relationship of APM2 expression with the mechanisms of CDDP resistance was examined in vitro and in vivo using hepatocellular carcinoma (HCC) cells, tissues and serum of HCC patients (n = 71) treated initially with intrahepatic arterial infusion of CDDP followed by surgical resection. The predictability of serum APM2 for CDDP sensitivity was assessed in additional 54 HCC patients and 14 gastric cancer (GC) patients. APM2 expression in CDDP-resistant HCC was significantly higher both in serum and the tissue. Bioinformatic analyses and histological analyses demonstrated upregulation of ERCC6L (DNA excision repair protein ERCC6-like) by APM2, which accounts for the degree of APM2 expression. The serum APM2 level and chemosensitivity for CDDP were assessed and cut-off value of serum APM2 for predicting the sensitivity to CDDP was determined to be 18.7 µg/mL. The value was assessed in HCC (n = 54) and GC (n = 14) patients for its predictability of CDDP sensitivity, resulted in predictive value of 77.3% and 100%, respectively. Our study demonstrated that APM2 expression is related to CDDP sensitivity and serum APM2 can be an effective biomarker of HCC and GC for determining the sensitivity to CDDP.Trial registration: This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000028487).

    DOI： 10.1038/s41598-021-85498-7

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  • Transcatheter Arterial Embolization Using Microspheres for Palliating Pain from Bone Metastasis in a Patient with Cholangiocellular Carcinoma.

    Shinichi Morita, Shunsuke Sugawara, Takeshi Suda, Didik Prasetyo, Takahiro Hoshi, Satoshi Abe, Kazuyoshi Yagi, Shuji Terai

    Internal medicine (Tokyo, Japan)   60 ( 2 )   241 - 246   2021.1

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    A 72-year-old man with intractable left shoulder pain due to bone metastasis from cholangiocellular carcinoma was admitted to our hospital. Computed tomography showed an osteoblastic metastatic lesion of the left scapula. Since the pain persisted even after the administration of opioids and external irradiation, microspheres were injected through a catheter; the catheter tip was placed at the arteries feeding the metastatic lesion. After the intervention, the shoulder pain was alleviated without any procedure-related complications, leading to a reduction in the opioid dose. This case suggests the efficacy of transcatheter arterial embolization using microspheres for palliating pain from bone metastasis.

    DOI： 10.2169/internalmedicine.5351-20

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  • Stent Placement for Malignant Inferior Vena Cava Syndrome in a Patient with Recurrent Colon Cancer.

    Shinichi Morita, Shunsuke Sugawara, Takeshi Suda, Didik Prasetyo, Yuka Kobayashi, Takahiro Hoshi, Satoshi Abe, Kazuyoshi Yagi, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 22 )   2885 - 2890   2020.11

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    A 70-year-old man was admitted to our hospital with gait disturbance due to marked edema of the lower limbs for more than 6 months. He had been receiving systemic chemotherapy over two years for multiple recurrence after sigmoid colon cancer resection. Contrast-enhanced computed tomography demonstrated severe inferior vena cava (IVC) stenosis due to compression by lymph node metastases, i.e. IVC syndrome. As increased doses of diuretic agents failed to improve the edema, IVC stent placement was performed. This led to significant improvement of the edema and complete gait normalization. This case demonstrates the efficacy of IVC stent placement for IVC syndrome.

    DOI： 10.2169/internalmedicine.5033-20

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  • Synchronous Double Bile Duct Cancers with Distinct Genetic Features.

    Shinichi Morita, Takeshi Suda, Yoji Kishi, Toshimitsu Iwasaki, Nobuyoshi Hiraoka, Itsuo Nagayama, Takahiro Hoshi, Satoshi Abe, Kazuyoshi Yagi, Go Hasegawa, Toshihiko Ikarashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 17 )   2129 - 2134   2020.9

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    A 69-year-old man was referred to our hospital because of appetite loss. Imaging showed a nodular tumor in the perihilar bile duct and a second flat lesion in the distal bile duct. Right hepatopancreaticoduodenectomy was performed, and the histopathological findings demonstrated that the perihilar and distal lesions were moderately and poorly differentiated adenocarcinoma, respectively, and anatomically separated. Furthermore, the resected specimens showed no pancreaticobiliary maljunction. Histological and TP53 gene analyses in a rare case of synchronous double bile duct cancers suggest that there are various genetic pathways through which bile duct cancer develops, highlighting the complexity of its pathogenesis.

    DOI： 10.2169/internalmedicine.4613-20

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  • 結腸ポリープを呈する成人ランゲルハンス細胞組織球症 症例報告と文献考察(Adult Langerhans cell histiocytosis presenting as a colonic polyp: case report and literature review)

    Korita Pavel, 味岡 洋一, 大橋 瑠子, 近藤 修平, 須田 剛士

    日本病理学会会誌   109 ( 1 )   431 - 431   2020.3

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    Language：English   Publisher：(一社)日本病理学会  

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  • Non-insulin-dependent Diabetes Mellitus Induced by Immune Checkpoint Inhibitor Therapy in an Insulinoma-associated Antigen-2 Autoantibody-positive Patient with Advanced Gastric Cancer.

    Nobumasa Ohara, Michi Kobayashi, Yohei Ikeda, Takahiro Hoshi, Shinichi Morita, Tsutomu Kanefuji, Kazuyoshi Yagi, Takeshi Suda, Toshinori Takada, Go Hasegawa, Yo Sato, Kenichiro Hirano, Shin-Ichi Kosugi

    Internal medicine (Tokyo, Japan)   59 ( 4 )   551 - 556   2020.2

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    A 70-year-old man with insulinoma-associated antigen-2 autoantibodies developed diabetes mellitus (DM) without ketoacidosis after starting nivolumab to treat advanced gastric cancer. He subsequently exhibited preserved insulin-secretion capacity for over one year. Immune checkpoint inhibitors (ICIs) infrequently cause type 1 DM associated with the rapid loss of insulin secretion and ketoacidosis as an immune-related adverse event. ICIs may also cause non-insulin-dependent DM by inducing insulin resistance if there is islet autoantibody-related latent beta-cell dysfunction. The present case highlights the importance of testing blood glucose levels regularly to diagnose DM in patients treated with ICIs, even if they do not have diabetic ketoacidosis.

    DOI： 10.2169/internalmedicine.3208-19

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  • Methotrexate-related lymphoproliferative disorders in the liver: Case presentation and mini-review. Reviewed International journal

    Takeshi Mizusawa, Kenya Kamimura, Hiroki Sato, Takeshi Suda, Hiroyuki Fukunari, Go Hasegawa, Osamu Shibata, Shinichi Morita, Akira Sakamaki, Junji Yokoyama, Yu Saito, Yoshihisa Hori, Yuduru Maruyama, Fumitoshi Yoshimine, Takahiro Hoshi, Shinichi Morita, Tsutomu Kanefuji, Masaaki Kobayashi, Shuji Terai

    World journal of clinical cases   7 ( 21 )   3553 - 3561   2019.11

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    BACKGROUND: Immunosuppression is effective in treating a number of diseases, but adverse effects such as bone marrow suppression, infection, and oncogenesis are of concern. Methotrexate is a key immunosuppressant used to treat rheumatoid arthritis. Although it is effective for many patients, various side effects have been reported, one of the most serious being methotrexate-related lymphoproliferative disorder. While this may occur in various organs, liver involvement is rare. Information on these liver lesions, including clinical characteristics, course, and imaging studies, has not been summarized to date. CASE SUMMARY: We present a case of 70-year-old woman presented with a 2-wk history of fever and abdominal pain. She had had rheumatoid arthritis for 5 years and was being treated with medication including methotrexate. Contrast-enhanced computed tomography revealed multiple low density tumors in the liver and the histological analyses showed significant proliferation of lymphocytes in masses that were positive on immunohistochemical staining for CD3, CD4, CD8, and CD79a but negative for CD20 and CD56. Staining for Epstein-Barr virus-encoded RNA was negative. And based on these findings, the liver tumors were diagnosed as Methotrexate-related lymphoproliferative disorders. A time-dependent disappearance of the liver tumors after stopping methotrexate supported the diagnoses. CONCLUSION: The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder.

    DOI： 10.12998/wjcc.v7.i21.3553

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  • Submucosal painting for gastroduodenal stent placement. Reviewed International journal

    Morita S, Suda T, Terai S

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 3 )   e64 - e65   2019.5

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    DOI： 10.1111/den.13349

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  • Rational arrangement of measuring shear wave speed in the liver. Reviewed International journal

    Yokoo T, Kanefuji T, Suda T, Nagayama I, Hoshi T, Abe S, Morita S, Kamimura H, Kamimura K, Tsuchiya A, Takamura M, Yagi K, Terai S

    World journal of gastroenterology   25 ( 20 )   2503 - 2513   2019.5

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    BACKGROUND: Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM: To provide procedural standardization of shear wave speed measurement. METHODS: Point shear wave elastography (pSWE) was measured in 781 patients, and two-dimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS: The CVR showed a significantly broader distribution in the left lobe (P < 0.0001), and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION: These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes.

    DOI： 10.3748/wjg.v25.i20.2503

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  • The Value of 18F-FDG PET in the Diagnosis of Intertrabecular Vertebral Metastasis in a Small Cell Lung Cancer Patient with a High Serum CEA Level.

    Shinichi Morita, Takeshi Suda, Chiyumi Oda, Masaaki Kobayashi, Takahiro Hoshi, Tsutomu Kanefuji, Kazuyoshi Yagi, Go Hasegawa, Shuji Terai

    Internal medicine (Tokyo, Japan)   58 ( 3 )   415 - 418   2019.2

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    We encountered a small cell lung cancer (SCLC) patient with intertrabecular vertebral metastasis (IVM). A 59-year-old man was admitted to our hospital with weight loss. 18F-fluorodeoxyglucose positron emission tomography (FDG PET)-CT demonstrated the uptake of fluorodeoxyglucose in the hilum of the left lung and whole-body bones. Despite intensive support, the patient died within a month. Subsequent autopsy revealed a small lesion consisting of small round cells in the left lung. The cancer cells were found to have spread through the replacement of the bone marrow cells while sparing the trabecular bone. This case demonstrated the potential of 18F-FDG PET for detecting IVM in SCLC patients.

    DOI： 10.2169/internalmedicine.1394-18

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  • EpCAM- and/or NCAM-Expressing Hepatocellular Carcinoma in Which Behavior of Hepatic Progenitor Cell Marker-Positive Cells Are Followed. Reviewed

    Tsuchiya A, Suda T, Oda C, Kimura A, Hosaka K, Kimura N, Tominaga K, Hayashi K, Takamura M, Terai S

    Case reports in gastroenterology   13 ( 1 )   118 - 124   2019.1

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    DOI： 10.1159/000498913

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  • A cut-off value of shear wave speed to distinguish nonalcoholic steatohepatitis candidates. Reviewed International journal

    Suda T, Kanefuji T, Abe A, Nagayama I, Hoshi T, Morita S, Yagi K, Hatakeyama S, Hayatsu M, Hasegawa N, Terai S

    Medicine   98 ( 2 )   e13958   2019.1

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    To distinguish and characterize nonalcoholic steatohepatitis (NASH) candidates from among medical checkup visitor diagnosed with nonalcoholic fatty liver diseases (mcNAFLDs).A cut-off value has not been established to differentiate NASH at the earliest stage in NAFLD.Shear wave speed (SWS) was measured in the livers of 480 mcNAFLDs. NASH candidates were screened out by adopting a statistically defined cut-off value of SWS and were characterized in terms of food preference.SWS ranged between 1.11 and 2.18 m/s and fit a Gaussian distribution (r = 0.98) with an average and SD of 1.324 and 0.0847 m/s, respectively, in 320/160 males/females 64.4 (interquartile range 57.3-69.4) years old. The average plus SD (1.41 m/s) screened out 82 (17.1%) NASH candidates, who were significantly older (66.8 vs. 64.1 years old, P = 0.001) and had higher fibrosis 4 index values (1.58 vs. 1.33, P < 0.0001) than the remaining mcNAFLDs. The number of patients with a BMI greater than 25 kg/m was 118 (29.6%) mcNAFLDs and 34 (41.5%) NASH candidates, with a significantly higher frequency in NASH candidates (P = 0.05). Obese patients preferentially ate fatty acids in general, while NASH candidates preferred to consume several long-chain unsaturated fatty acids irrespective of their BMI.These results suggest that NASH candidates who have a longer disease duration and pathological progression can be distinguished from mcNAFLDs by a statistically defined cut-off value of SWS. The defined value indicates that there are different food habitats associated with obesity and NAFLD progression.

    DOI： 10.1097/MD.0000000000013958

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  • Green epithelium revealed by narrow-band imaging (NBI): a feature for practical assessment of extent of gastric cancer after <i>H. pylori</i> eradication. Reviewed

    Yagi K, Nagayama I, Hoshi T, Abe S, Morita SI, Suda T, Hasegawa G, Sato YI, Terai S

    Endoscopy international open   6 ( 11 )   E1289 - E1295   2018.11

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  • Endoscopic ultrasound-guided transmural drainage for subphrenic abscess: Report of two cases and a literature review Reviewed

    Shinichi Morita, Kenya Kamimura, Takeshi Suda, Chiyumi Oda, Takahiro Hoshi, Tsutomu Kanefuji, Kazuyoshi Yagi, Shuji Terai

    BMC Gastroenterology   18 ( 1 )   55 - 55   2018.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：BioMed Central Ltd.  

    DOI： 10.1186/s12876-018-0782-2

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  • Gastric Metastasis From Uveal Melanoma. Reviewed

    Morita S, Suda T, Terai S

    Clin Gastroenterol Hepatol   18   30330 - 30336   2018

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  • The Value of (18)F-FDG PET in the Diagnosis of Intertrabecular Vertebral Metastasis in a Small Cell Lung Cancer Patient with a High Serum CEA Level. Reviewed

    Morita S, Suda T, Oda C, Kobayashi M, Hoshi T, Kanefuji T, Yagi K, Hasegawa G, Terai S

    Intern Med   1394 - 1318   2018

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  • Successful treatment of aortic dissection during sorafenib therapy for hepatocellular carcinoma. Reviewed International journal

    Tsuchiya A, Ogawa M, Watanabe Y, Kimura N, Hayashi K, Suda T, Terai S

    Clin Case Rep   6 ( 8 )   1643 - 1644   2018

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    Our case highlights the need for caution during vascular endothelial growth factor pathway inhibitor (VPI) therapy and for the occurrence of aortic dissection. If Stanford classification type A aortic dissection occurs during VPI therapy, surgical intervention should be considered to prevent cardiac tamponade if the patient's clinical condition permits it.

    DOI： 10.1002/ccr3.1674

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  • Effective prevention of sorafenib-induced hand-foot syndrome by dried-bonito broth. Reviewed International journal

    Kenya Kamimura, Yoko Shinagawa-Kobayashi, Ryo Goto, Kohei Ogawa, Takeshi Yokoo, Akira Sakamaki, Satoshi Abe, Hiroteru Kamimura, Takeshi Suda, Hiroshi Baba, Takayuki Tanaka, Yoshizu Nozawa, Naoto Koyama, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Yutaka Aoyagi, Shuji Terai

    Cancer management and research   10   805 - 813   2018

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    Background: Sorafenib (SOR) is a molecular medicine that prolongs the survival of patients with hepatocellular carcinoma (HCC). Therefore, the management of side effects is essential for the longer period of continuous medication. Among the various side effects, hand-foot syndrome (HFS) is the most common, occurring in 30%-50% of patients, and often results in discontinuation of the SOR medication. However, its mechanism has not been clarified, and no effective prevention method has been reported for the symptoms. Therefore, this study aimed to analyze its mechanism and to develop an effective prevention regimen for the symptoms. Materials and methods: To assess the mechanism of SOR-induced HFS, the peripheral blood flow in the hand and foot was carefully monitored by Doppler ultrasound, thermography, and laser speckle flowgraphy in the cases treated with SOR and its contribution was assessed. Then, the effect of dried-bonito broth (DBB), which was reported to improve peripheral blood flow, on the prevention of the symptom was examined by monitoring its occurrence and the peripheral blood flow. Results: A total of 25 patients were enrolled in this study. In all, eight patients developed HFS, and all cases showed a significant decrease in the peripheral blood flow. DBB contributed to an increase in the flow (p = 0.009) and significantly decreased occurrence of HFS (p = 0.005) than control. Multivariable analysis showed that the ingestion of DBB is a significant independent contributor to HFS-free survival period (p = 0.035). Conclusion: The mechanism of SOR-induced HFS involves a decrease in the peripheral blood flow, and the ingestion of DBB effectively prevents the development of the syndrome by maintaining the flow.

    DOI： 10.2147/CMAR.S159370

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  • Gastric Cancer after H. pylori Eradication therapy develops in the Intermediate Zone. Relationship to Spasmolytic Polypeptide-Expressing Metaplasia Reviewed

    Kazuyoshi Yagi, Itsuo Nagayama, Takahiro Hoshi, Satoshi Abe, Shinichi Morita, Takeshi Suda, Yu-ichi Sato, Shuji Terai

    Open Access J Surg   9   1 - 6   2018

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  • The use of clip anchoring to ensure safe transgastric puncture during endoscopic ultrasound-guided transmural drainage Reviewed

    Shinichi Morita, Kazuo Hara, Takeshi Suda, Susumu Hijioka, Nozomi Okuno, Masaaki Kobayashi, Shuji Terai

    ENDOSCOPY   49 ( 7 )   E186 - E187   2017.7

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    DOI： 10.1055/s-0043-109428

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  • Effect of double platinum agents, combination of miriplatintransarterial oily chemoembolization and cisplatinhepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma: Report of two cases Reviewed

    Kohei Ogawa, Kenya Kamimura, Yukari Watanabe, Yosuke Motai, Daisuke Kumaki, Ryoya Seki, Akira Sakamaki, Satoshi Abe, Hirokazu Kawai, Takeshi Suda, Satoshi Yamagiwa, Shuji Terai

    WORLD JOURNAL OF CLINICAL CASES   5 ( 6 )   238 - 246   2017.6

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    DOI： 10.12998/wjcc.v5.i6.238

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  • 内視鏡的バルーン拡張術抵抗性の食道良性狭窄に対しRIC法が有効であった2例

    小林 正明, 佐藤 洋, 水澤 健, 星 隆洋, 森田 慎一, 兼藤 努, 須田 剛士, 小杉 伸一

    日本食道学会学術集会プログラム・抄録集   71回   P68 - 4   2017.6

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  • Transhepatic arterial infusion chemotherapy using a combination of miriplatin and CDDP powder versus miriplatin alone in the treatment of hepatocellular carcinoma: a randomized controlled trial Reviewed

    Kenya Kamimura, Takeshi Suda, Takeshi Yokoo, Hiroteru Kamimura, Tsutomu Kanefuji, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Satoshi Yamagiwa, Shuji Terai

    BMC CANCER   17   322 - 322   2017.5

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    DOI： 10.1186/s12885-017-3320-7

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  • A novel technique for biliary biopsy using the sheath of a plastic stent and a non-return valve Reviewed

    Shinichi Morita, Tsutomu Kanefuji, Takahiro Hoshi, Masaaki Kobayashi, Takeshi Suda, Takeshi Mizusawa, Shuji Terai

    ENDOSCOPY   49 ( S01 )   E9 - E10   2017.2

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    DOI： 10.1055/s-0042-118704

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  • Prognostic Impact of Indocyanine Green Plasma Disappearance Rate in Hepatocellular Carcinoma Patients after Radiofrequency Ablation: A Prognostic Nomogram Study Reviewed

    Motoi Azumi, Takeshi Suda, Shuji Terai, Kouhei Akazawa

    INTERNAL MEDICINE   56 ( 9 )   1001 - 1007   2017

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    DOI： 10.2169/internalmedicine.56.7278

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  • Magnifying image-enhanced endoscopy for collagenous colitis. Reviewed

    Kobayashi M, Hoshi T, Morita SI, Kanefuji T, Suda T, Hasegawa G, Terai S

    Endosc Int Open   5   E1069 - E1073   2017

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  • [Series: Diagnosis at a Glance]. Reviewed

    Kobayashi T, Tsuchiya A, Kuraoka N, Yamamoto T, Honda Y, Yokoyama J, Kawai H, Yamagiwa S, Suda T, Terai S

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   105 ( 11 )   2263 - 2267   2016.11

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  • Transhepatic arterial chemotherapy using a combination of miriplatin and CDDP powder in patients with hepatocellular carcinoma Reviewed

    Kenya Kamimura, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Toru Ishikawa, Takeshi Suda, Satoshi Yamagiwa, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   361 - 361   2016.11

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  • Liver-targeted hydrodynamic gene therapy: Recent advances in the technique Reviewed

    Takeshi Yokoo, Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Tsutomu Kanefuji, Kohei Ogawa, Ryo Goto, Masafumi Oda, Takeshi Suda, Shuji Terai, Masafumi Oda

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 40 )   8862 - 8868   2016.10

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    DOI： 10.3748/wjg.v22.i40.8862

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  • Platinum-based transhepatic arterial chemotherapy using a combination of miriplatin and CDDP powder in patients with hepatocellular carcinoma Reviewed

    Kohei Ogawa, Kenya Kamimura, Takeshi Suda, Takeshi Yokoo, Akira Sakamaki, Satoshi Abe, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Toru Ishikawa, Satoshi Yamagiwa, Shuji Terai

    HEPATOLOGY   64   652A - 652A   2016.10

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  • Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery Reviewed

    Yuji Kobayashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Yokoo, Kohei Ogawa, Yoko Shinagawa-Kobayashi, Ryo Goto, Ryosuke Inoue, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   5   e359 - e359   2016.8

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    DOI： 10.1038/mtna.2016.63

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  • [Effective Prevention of Hand-Foot Syndrome by the Consumption of Dried Bonito Broth]. Reviewed

    Kenya Kamimura, Yoko Shinagawa, Kohei Ogawa, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Hiroteru Kamimura, Hirokazu Kawai, Takeshi Suda, Satoshi Yamagiwa, Hiroshi Baba, Shuji Terai

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 4 )   463 - 5   2016.4

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    To examine whether the consumption of dried bonito both is effective for the prevention of hand-foot syndrome(HFS), concentrated bonito broth was administered to 10 patients with HCC who were treated with sorafenib. Among the 10 patients, seven showed an increase in peripheral blood flow, as observed on Doppler ultrasonography. Only one patient showed Grade 1 HFS on day 14 after the initiation of sorafenib (10%); this incidence rate of HFS was significantly lower than that obtained in our previous studies and reported data. These results suggest that consumption of dried bonito broth contributes to the prevention of HFS by maintaining peripheral blood flow.

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  • Kupffer phase image of Sonazoid-enhanced US is useful in predicting a hypervascularization of non-hypervascular hypointense hepatic lesions detected on Gd-EOB-DTPA-enhanced MRI: a multicenter retrospective study Reviewed

    Tatsuo Inoue, Tomoko Hyodo, Keiko Korenaga, Takamichi Murakami, Yasuharu Imai, Atsushi Higaki, Takeshi Suda, Toru Takano, Kennichi Miyoshi, Masahiko Koda, Hironori Tanaka, Hiroko Iijima, Hironori Ochi, Masashi Hirooka, Kazushi Numata, Masatoshi Kudo

    JOURNAL OF GASTROENTEROLOGY   51 ( 2 )   144 - 152   2016.2

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    DOI： 10.1007/s00535-015-1094-8

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  • Image-guided hydrodynamic gene delivery to the liver: Toward clinical applications Reviewed

    Kenya Kamimura, Takeshi Suda, Tsutomu Kanefuji

    Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects   85 - 92   2016.1

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    DOI： 10.1007/978-4-431-55666-4_8

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  • Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model Reviewed

    Hiroyuki Abe, Kenya Kamimura, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Riuko Ohashi, Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   5   e276 - e276   2016.1

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    DOI： 10.1038/mtna.2015.49

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  • Advanced diagnostic endoscopy for gastric cancers discovered after H. pylori eradication. Reviewed

    Kobayashi M, Hoshi T, Morita S, Kanefuji T, Suda T, Mizuno K, Hashimoto S, Takeuchi M, Sato Y, Terai S

    Nihon Shokakibyo Gakkai Zasshi   113 ( 2 )   235 - 244   2016

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    DOI： 10.11405/nisshoshi.113.235

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    Other Link： http://search.jamas.or.jp/link/ui/2016186705

  • Three Times Repeated Portal Venous Gas after Meals Reviewed

    Takamasa Kobayashi, Atsunori Tsuchiya, Takeshi Suda, Shuji Terai

    INTERNAL MEDICINE   55 ( 7 )   843 - 845   2016

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    DOI： 10.2169/internalmedicine.55.6036

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  • Improvement of Pancreatic Tumor-induced NAFLD with Pancrelipase Reviewed

    Naosuke Kuraoka, Atsunori Tsuchiya, Takeshi Suda, Shuji Terai

    INTERNAL MEDICINE   55 ( 1 )   89 - 90   2016

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    DOI： 10.2169/internalmedicine.55.5729

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  • Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy Reviewed

    Kanae Hirose, Tsutomu Kanefuji, Takeshi Suda, Souichi Sugitani, Keisuke Nagasaki, Tomoyuki Kubota, Masato Igarashi, Shuji Terai

    GASTROENTEROLOGY RESEARCH AND PRACTICE   2016

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    DOI： 10.1155/2016/6343656

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  • A case of benign Biliary stricture after choledochojejunostomy that was successfully managed using a fully covered self-expanding metallic stent

    Shinichi Morita, Toru Setsu, Takahiro Hoshi, Tsutomu Kanefuji, Masaaki Kobayashi, Takeshi Suda, Shuji Terai

    Gastroenterological Endoscopy   58 ( 11 )   2279 - 2286   2016

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  • Site-specific impact of a regional hydrodynamic injection: Computed tomography study during hydrodynamic injection targeting the swine liver Reviewed

    Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Kenya Kamimura, Dexi Liu, Shuji Terai

    Pharmaceutics   7 ( 3 )   334 - 343   2015.9

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    DOI： 10.3390/pharmaceutics7030334

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  • Rheological modification of hydrodynamic gene delivery

    Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Akiomi Ushida, Tomiichi Hasegawa, Kenya Kamimura, Dexi Liu, Shuji Terai

    Proceedings of The 18th Annual Meeting of the American Society of Gene and Cell Therapy   ( 350594 )   140 - 141   2015.5

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  • Effective Prevention of Liver Fibrosis by Liver-Targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in Rat Liver Fibrosis Model Reviewed

    Abe Hiroyuki, Kamimura Kenya, Kobayashi Yuji, Ohtsuka Masato, Miura Hiromi, Ohashi Riuko, Yokoo Takeshi, Kanefuji Tsutomu, Suda Takeshi, Tsuchida Masanori, Aoyagi Yutaka, Zhang Guisheng, Liu Dexi, Terai Shuji

    MOLECULAR THERAPY   23   S234   2015.5

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  • Effect of Fibrotic Tissue on Liver-Targeted Hydrodynamic Gene Delivery Reviewed

    Kobayashi Yuji, Kamimura Kenya, Abe Hiroyuki, Ohtsuka Masato, Miura Hiromi, Yokoo Takeshi, Kanefuji Tsutomu, Suda Takeshi, Zhang Guisheng, Tsuchida Masanori, Aoyagi Yutaka, Liu Dexi, Terai Shuji

    MOLECULAR THERAPY   23   S141   2015.5

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  • Factors predicting aggressiveness of non-hypervascular hepatic nodules detected on hepatobiliary phase of gadolinium ethoxybenzyl diethylene-triamine-pentaacetic-acid magnetic resonance imaging Reviewed

    Tsutomu Kanefuji, Toru Takano, Takeshi Suda, Kouhei Akazawa, Takeshi Yokoo, Hiroteru Kamimura, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Hidefumi Aoyama, Minoru Nomoto, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 15 )   4583 - 4591   2015.4

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    DOI： 10.3748/wjg.v21.i15.4583

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  • Late Onset Post-Transfusion Hepatitis E Developing during Chemotherapy for Acute Promyelocytic Leukemia Reviewed

    Kyoko Fuse, Yuichi Matsuyama, Masato Moriyama, Shukuko Miyakoshi, Yasuhiko Shibasaki, Jun Takizawa, Tatsuo Furukawa, Ichiro Fuse, Hiro Matsumura, Shigeharu Uchida, Yoshifumi Takahashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Suda, Yutaka Aoyagi, Hirohito Sone, Masayoshi Masuko

    INTERNAL MEDICINE   54 ( 6 )   657 - 661   2015

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    DOI： 10.2169/internalmedicine.54.2332

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  • Increase of fucosylated alpha-fetoprotein fraction at the onset of autoimmune hepatitis and acute liver failure Reviewed

    Satoshi Yamagiwa, Yasushi Tamura, Masaaki Takamura, Takuya Genda, Takafumi Ichida, Toru Ishikawa, Tomoteru Kamimura, Toru Takahashi, Takeshi Suda, Yasunobu Matsuda, Minoru Nomoto, Yutaka Aoyagi

    HEPATOLOGY RESEARCH   44 ( 14 )   E368 - E375   2014.12

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    DOI： 10.1111/hepr.12318

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  • Safety Assessment of Liver-Targeted Hydrodynamic Gene Delivery in Dogs Reviewed

    Kenya Kamimura, Tsutomu Kanefuji, Takeshi Yokoo, Hiroyuki Abe, Takeshi Suda, Yuji Kobayashi, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu

    PLOS ONE   9 ( 9 )   e107203 - e107203   2014.9

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    DOI： 10.1371/journal.pone.0107203

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  • 超音波診断装置を用いた肝の弾性診断「肝硬度」は肝うっ血に影響される

    杉本 愛, 高橋 昌, 須田 剛士, 白石 修一, 渡邊 マヤ, 土田 正則

    日本小児循環器学会雑誌   30 ( Suppl. )   s279 - s279   2014.6

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  • Overexpression of Matrix Metalloproteinase-13 Gene by the Method of Hydrodynamic Gene Delivery Prevents Liver Fibrosis in Rats Reviewed

    Hiroyuki Abe, Kenya Kamimura, Takeshi Yokoo, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Dexi Liu, Yutaka Aoyagi

    MOLECULAR THERAPY   22   S133 - S133   2014.5

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  • Value of shear wave velocity measurements for the risk assessment of hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease Reviewed

    Masaaki Takamura, Tsutomu Kanefuji, Takeshi Suda, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, Kenya Kamimura, Yasushi Tamura, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa, Minoru Nomoto, Yutaka Aoyagi

    HEPATOLOGY INTERNATIONAL   8 ( 2 )   240 - 249   2014.4

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    DOI： 10.1007/s12072-014-9517-9

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  • Granulocytapheresis for the Treatment of Severe Alcoholic Hepatitis: A Case Series and Literature Review Reviewed

    Kenya Kamimura, Michitaka Imai, Akira Sakamaki, Shigeki Mori, Masaaki Kobayashi, Ken-ichi Mizuno, Manabu Takeuchi, Takeshi Suda, Minoru Nomoto, Yutaka Aoyagi

    DIGESTIVE DISEASES AND SCIENCES   59 ( 2 )   482 - 488   2014.2

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    DOI： 10.1007/s10620-013-2871-y

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  • Alcoholic Liver Disease Complicated by Deep Bleeding into the Muscles or Retroperitoneum: Report of Three Cases and a Review of the Literature Reviewed

    Masaaki Takamura, Jun Watanabe, Akira Sakamaki, Yutaka Honda, Kenya Kamimura, Atsunori Tsuchiya, Satoshi Yamagiwa, Takeshi Suda, Yasunobu Matsuda, Yutaka Aoyagi

    INTERNAL MEDICINE   53 ( 16 )   1763 - 1768   2014

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    DOI： 10.2169/internalmedicine.53.2123

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  • Hemodynamics of a hydrodynamic injection Reviewed

    Tsutomu Kanefuji, Takeshi Yokoo, Takeshi Suda, Hiroyuki Abe, Kenya Kamimura, Dexi Liu

    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT   1   14029 - 14029   2014

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    DOI： 10.1038/mtm.2014.29

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  • Gene Therapy for Liver Fibrosis. Reviewed

    Abe H, Kamimura K, Yokoo T, Suda T, Kobayashi Y, Aoyagi Y

    JSM Gastroenterol Hepatol   2   1028   2014

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  • Parameters Affecting Image-guided, Hydrodynamic Gene Delivery to Swine Liver Reviewed

    Kenya Kamimura, Takeshi Suda, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu

    MOLECULAR THERAPY-NUCLEIC ACIDS   2 ( 10 )   e128 - e128   2013.10

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    DOI： 10.1038/mtna.2013.52

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  • Novel electric power-driven hydrodynamic injection system for gene delivery: Safety and efficacy of human factor IX delivery in rats Reviewed

    T. Yokoo, K. Kamimura, T. Suda, T. Kanefuji, M. Oda, G. Zhang, D. Liu, Y. Aoyagi

    Gene Therapy   20 ( 8 )   816 - 823   2013.8

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    DOI： 10.1038/gt.2013.2

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  • Value of Highly Sensitive Fucosylated Fraction of Alpha-Fetoprotein for Prediction of Hepatocellular Carcinoma Recurrence After Curative Treatment Reviewed

    Yasushi Tamura, Takeshi Suda, Shigeki Arii, Michio Sata, Fuminori Moriyasu, Hiroshi Imamura, Seiji Kawasaki, Namiki Izumi, Tadatoshi Takayama, Norihiro Kokudo, Masakazu Yamamoto, Hiroko Iijima, Yutaka Aoyagi

    DIGESTIVE DISEASES AND SCIENCES   58 ( 8 )   2406 - 2412   2013.8

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    DOI： 10.1007/s10620-013-2661-6

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  • Active treatments are a rational approach for hepatocellular carcinoma in elderly patients Reviewed

    Takeshi Suda, Aiko Nagashima, Shyunsaku Takahashi, Tsutomu Kanefuji, Kenya Kamimura, Yasushi Tamura, Masaaki Takamura, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa, Minoru Nomoto, Yutaka Aoyagi

    WORLD JOURNAL OF GASTROENTEROLOGY   19 ( 24 )   3831 - 3840   2013.6

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    DOI： 10.3748/wjg.v19.i24.3831

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  • Low fat intake is associated with pathological manifestations and poor recovery in patients with hepatocellular carcinoma Reviewed

    Kazuki Yamada, Takeshi Suda, Yuko S. Komoro, Tsutomu Kanefuji, Tomoyuki Kubota, Toshiko Murayama, Hideaki Nakayama, Yutaka Aoyagi

    NUTRITION JOURNAL   12   79 - 85   2013.6

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    DOI： 10.1186/1475-2891-12-79

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  • Successful laparoscopic division of a patent ductus venosus: report of a case Reviewed

    Yoshiaki Hara, Yoshinobu Sato, Satoshi Yamamoto, Hiroshi Oya, Masato Igarashi, Satoshi Abe, Hidenaka Kokai, Kohei Miura, Takeshi Suda, Minoru Nomoto, Yutaka Aoyagi, Katsuyoshi Hatakeyama

    SURGERY TODAY   43 ( 4 )   434 - 438   2013.4

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    DOI： 10.1007/s00595-012-0316-4

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  • 肝炎から肝硬変・肝癌まで 肝癌の早期発見 腫瘍マーカー

    田村康, 上村顕也, 五十嵐正人, 川合弘一, 須田剛士, 青柳豊

    月刊臨床と研究   90 ( 2 )   200 - 203   2013.2

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  • A safe and effective dose of cisplatin in hepatic arterial infusion chemotherapy for hepatocellular carcinoma Reviewed

    Akihiko Osaki, Takeshi Suda, Kenya Kamimura, Atsunori Tsuchiya, Yasushi Tamura, Masaaki Takamura, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa, Yutaka Aoyagi

    CANCER MEDICINE   2 ( 1 )   86 - 98   2013.2

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    DOI： 10.1002/cam4.55

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  • Hypovascular hepatic nodules showing hypointense on the hepatobiliary-phase image of Gd-EOB-DTPA-enhanced MRI to develop a hypervascular hepatocellular carcinoma: A nationwide retrospective study on their natural course and risk factors Reviewed

    Tatsuo Inoue, Tomoko Hyodo, Takamichi Murakami, Yukihisa Takayama, Akihiro Nishie, Atsushi Higaki, Keiko Korenaga, Azusa Sakamoto, Yukio Osaki, Hiroshi Aikata, Kazuaki Chayama, Takeshi Suda, Toru Takano, Kennichi Miyoshi, Masahiko Koda, Kazushi Numata, Hironori Tanaka, Hiroko Iijima, Hironori Ochi, Masashi Hirooka, Yasuharu Imai, Masatoshi Kudo

    Digestive Diseases   31 ( 5-6 )   472 - 479   2013

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    DOI： 10.1159/000355248

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  • Liver-directed Gene Therapy. Reviewed

    Kamimura K, Abe H, Suda T, Aoyagi Y, Liu D

    JSM Gastroenterology and Hepatology   1   1005 - 1007   2013

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  • Phase I study of miriplatin combined with transarterial chemotherapy using CDDP powder in patients with hepatocellular carcinoma Reviewed

    Kenya Kamimura, Takeshi Suda, Yasushi Tamura, Masaaki Takamura, Takeshi Yokoo, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa, Minoru Nomoto, Yutaka Aoyagi

    BMC GASTROENTEROLOGY   12   127 - 127   2012.9

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    DOI： 10.1186/1471-230X-12-127

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  • Formula to Predict Platelet Count after Partial Splenic Arterial Embolization in Patients with Hypersplenism Reviewed

    Akihiko Osaki, Takeshi Suda, Nobuo Waguri, Toru Ishikawa, Takeshi Yokoo, Kenya Kamimura, Yasushi Tamura, Masaaki Takamura, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa, Yutaka Aoyagi

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY   23 ( 7 )   900 - 907   2012.7

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    DOI： 10.1016/j.jvir.2012.03.008

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  • 肝性脳症に対するB-RTO Reviewed

    和栗 暢生, 林 雅博, 佐藤 宗広, 薛 徹, 池野 嘉信, 佐藤 里映, 荒生 祥尚, 河久 順志, 濱 勇, 大杉 香織, 横尾 健, 相場 恒男, 米山 靖, 古川 浩一, 杉村 一仁, 五十嵐 健太郎, 須田 剛士

    日本門脈圧亢進症学会雑誌   18 ( 2 )   111 - 118   2012.6

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    肝性脳症に対しバルーン下逆行性経静脈的塞栓術(B-RTO)を施行した14例(男9例、女5例、平均64.5歳)の成績を報告した。門脈大循環シャントの部位は胃腎7例、脾腎5例、mesocaval 3例、奇静脈1例、傍臍静脈1例であった。10例でB-RTO施行による門脈圧上昇緩和目的で部分脾動脈塞栓術を施行した。シャント血管の完全な塞栓が得られなかったのは2例で、1例は翌日バルーン破損を認め、他の1例は排血路が多彩でコイル塞栓が中心であった。残り12例は完全な塞栓が得られ、血中アンモニア値正常化と脳症症状改善が認められた。術後合併症は症候性胸腹水4例、特発性細菌性腹膜炎或いは敗血症2例、門脈血栓症1例、麻痺性イレウス1例が認められた。術後2ヵ月以上経過した13例において、血中アンモニア値は正常値維持4例、時折軽度上昇5例、再上昇し高値持続2例、低下なし2例であった。顕性脳症は3例に認め、うち2例は肝病変進展によるものであった。

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  • Simultaneous Combined Balloon-occluded Retrograde Transvenous Obliteration and Partial Splenic Embolization for Portosystemic Shunts Reviewed

    Nobuo Waguri, Masahiro Hayashi, Takeshi Yokoo, Rie Sato, Yoshihisa Arao, Toru Setsu, Munehiro Sato, Junji Kohisa, Isamu Hama, Kaori Ohsugi, Tsuneo Aiba, Osamu Yoneyama, Koichi Furukawa, Kazuhito Sugimura, Kentaro Igarashi, Takeshi Suda

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY   23 ( 5 )   650 - 657   2012.5

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    DOI： 10.1016/j.jvir.2012.01.065

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  • Efficient palliative involved-field radiotherapy on highly progressive diffuse large B-cell primary gastric lymphoma with liver cirrhosis Reviewed

    Junji Kohisa, Kenya Kamimura, Akito Iwanaga, Kazuhiko Shioji, Hirokazu Kawai, Takeshi Suda, Kenji Suzuki, Junko Sakurada, Makoto Naito, Yutaka Aoyagi

    Clinical Journal of Gastroenterology   5 ( 2 )   164 - 169   2012.4

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    DOI： 10.1007/s12328-012-0292-7

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  • Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis Reviewed

    M. Friedrich-Rust, J. Nierhoff, M. Lupsor, I. Sporea, C. Fierbinteanu-Braticevici, D. Strobel, H. Takahashi, M. Yoneda, T. Suda, S. Zeuzem, E. Herrmann

    JOURNAL OF VIRAL HEPATITIS   19 ( 2 )   E212 - E219   2012.2

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    DOI： 10.1111/j.1365-2893.2011.01537.x

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  • Identification of cellular genes showing differential expression associated with hepatitis B virus infection Reviewed

    Yasuo Fukuhara, Takeshi Suda, Makoto Kobayashi, Yasushi Tamura, Masato Igarashi, Nobuo Waguri, Hirokazu Kawai, Yutaka Aoyagi

    World Journal of Hepatology   4 ( 4 )   139 - 148   2012

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    DOI： 10.4254/wjh.v4.i4.139

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  • 非B非C型肝癌の現状と問題点 Cryptogenic肝癌と他の非B非C型肝癌の臨床病理学的比較

    川合弘一, 須田剛士, 上村顕也, 田村康, 五十嵐正人, 野本実, 岡田正彦, 青柳豊

    月刊消化器内科   53 ( 4 )   440 - 446   2011.10

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  • Advances in Gene Delivery Systems. Reviewed

    Kamimura K, Suda T, Zhang G, Liu D

    Pharmaceutical medicine   25   293 - 306   2011.10

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  • Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM Reviewed

    Atsunori Tsuchiya, Hiroteru Kamimura, Yasushi Tamura, Masaaki Takamura, Satoshi Yamagiwa, Takeshi Suda, Minoru Nomoto, Yutaka Aoyagi

    CANCER LETTERS   309 ( 1 )   95 - 103   2011.10

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    DOI： 10.1016/j.canlet.2011.05.021

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  • Alpha-fetoprotein-producing adenocarcinoma in which the metastatic route was determined from calcified lesions Reviewed

    Atsunori Tsuchiya, Tsutomu Kanefuji, Takeshi Suda, Tomoya Aoyagi, Akihiko Osaki, Tadayuki Togashi, Yusuke Kawauchi, Mae Fushiki, Gen Watanabe, Masaki Hirota, Minoru Nomoto, Yoichi Ajioka, Yutaka Aoyagi

    Clinical Journal of Gastroenterology   4 ( 2 )   89 - 94   2011.4

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    DOI： 10.1007/s12328-011-0209-x

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  • History and recent progress in evaluation of the fucosylated alpha-fetoprotein fraction Reviewed

    Yutaka Aoyagi, Yasushi Tamura, Takeshi Suda

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   26 ( 4 )   615 - 616   2011.4

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    DOI： 10.1111/j.1440-1746.2011.06671.x

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  • 非アルコール性脂肪肝炎における、肝内複数セグメントを対象とした経時的せん断弾性波速度測定の有用性

    須田 剛士, 横尾 健, 長崎 啓祐, 原田 浩一, 窪田 智之, 菊池 透, 上村 朝輝, 青柳 豊

    日本内科学会雑誌   100 ( Suppl. )   207 - 207   2011.2

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  • Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis Reviewed

    Hirokazu Kawai, Minoru Nomoto, Takeshi Suda, Kenya Kamimura, Atsunori Tsuchiya, Yasushi Tamura, Masahiko Yano, Masaaki Takamura, Masato Igarashi, Toshifumi Wakai, Satoshi Yamagiwa, Yasunobu Matsuda, Shogo Ohkoshi, Isao Kurosaki, Yoshio Shirai, Masahiko Okada, Yutaka Aoyagi

    World Journal of Hepatology   3 ( 1 )   15 - 23   2011

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    DOI： 10.4254/wjh.v3.i1.15

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  • Drugs aimed for Hepatobiliary,Pancreatic Diseaes for this 30 years. A role of anthracycline chemotherapeutic agents in interventuonal radiology for hepatocellular carcinoma

    SUDA TAKESHI, UEMURA KEN'YA, TAMURA KO, IGARASHI MASATO, KAWAI HIROKAZU, AOYAGI YUTAKA

    肝胆膵   61 ( 6 )   1120 - 1124   2010.12

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  • Clinical Advantage of Highly Sensitive On-Chip Immunoassay for Fucosylated Fraction of Alpha-Fetoprotein in Patients with Hepatocellular Carcinoma Reviewed

    Yasushi Tamura, Masato Igarashi, Hirokazu Kawai, Takeshi Suda, Shinji Satomura, Yutaka Aoyagi

    DIGESTIVE DISEASES AND SCIENCES   55 ( 12 )   3576 - 3583   2010.12

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    DOI： 10.1007/s10620-010-1222-5

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  • 肝細胞癌以外の肝腫瘍 肝類上皮血管内皮腫

    上村顕也, 須田剛士, 青柳豊

    日本臨床   225 - 228   2010.10

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  • Fucosylated Fraction of Alpha-Fetoprotein as a Predictor of Prognosis in Patients with Hepatocellular Carcinoma After Curative Treatment Reviewed

    Yasushi Tamura, Masato Igarashi, Takeshi Suda, Toshifumi Wakai, Yoshio Shirai, Takeji Umemura, Eiji Tanaka, Satoru Kakizaki, Hitoshi Takagi, Yoichi Hiasa, Morikazu Onji, Yutaka Aoyagi

    DIGESTIVE DISEASES AND SCIENCES   55 ( 7 )   2095 - 2101   2010.7

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    DOI： 10.1007/s10620-009-0954-6

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  • Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis Reviewed

    Akihiko Osaki, Tomoyuki Kubota, Takeshi Suda, Masato Igarashi, Keisuke Nagasaki, Atsunori Tsuchiya, Masahiko Yano, Yasushi Tamura, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Toru Kikuchi, Minoru Nomoto, Yutaka Aoyagi

    WORLD JOURNAL OF GASTROENTEROLOGY   16 ( 23 )   2918 - 2925   2010.6

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    DOI： 10.3748/wjg.v16.i23.2918

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  • Serum Alpha-Fetoprotein Levels During and After Interferon Therapy and the Development of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C Reviewed

    Yasushi Tamura, Satoshi Yamagiwa, Yohei Aoki, So Kurita, Takeshi Suda, Shogo Ohkoshi, Minoru Nomoto, Yutaka Aoyagi

    DIGESTIVE DISEASES AND SCIENCES   54 ( 11 )   2530 - 2537   2009.11

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    DOI： 10.1007/s10620-008-0642-y

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  • Synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type C liver cirrhosis. Reviewed International journal

    Watanabe T, Sakata J, Ishikawa T, Shirai Y, Suda T, Hirono H, Hasegawa K, Soga K, Shibasaki K, Saito Y, Umezu H

    World journal of hepatology   1 ( 1 )   103 - 109   2009.10

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    As a result of having undergone computed tomography (CT), a 75-year-old woman with type-C liver cirrhosiswas shown to have two tumors on the ventral and dorsal sides of subsegment 3 (S3). The tumor on the ventral side was diagnosed as a classic hepatocellular carcinoma (HCC), while that on the dorsal side was considered atypical for a HCC. Although the indocyanine green (ICG) findings indicated poor hepatic reserve, the prothrombin time (PT) was relatively good. An operation was performed in February 2007; however, this resulted in exploratory laparotomy. Dynamic CT performed 12 mo after the operation revealed that the tumor on the dorsal side of S3 had apparently increased. The marginal portion of the tumor was shown to be in the early and parenchymal phases, while the internal portion was found to have grown only slightly in the delayed phase. We diagnosed this tumor as a cholangiocellular carcinoma (CCC). S3 subsegmentectomy was performed in April 2008. The tumor on the ventral side was pathologically diagnosed as a moderately differentiated HCC, and that on the dorsal side was diagnosed as a CCC. We can therefore report a rare case of synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type-C liver cirrhosis. We also add a literature review for all the reported cases published in Japan and around the world, and summarize the features of double cancer exhibiting both HCC and CCC.

    DOI： 10.4254/wjh.v1.i1.103

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  • Image-guided, Lobe-specific Hydrodynamic Gene Delivery to Swine Liver Reviewed

    Kenya Kamimura, Takeshi Suda, Wei Xu, Guisheng Zhang, Dexi Liu

    MOLECULAR THERAPY   17 ( 3 )   491 - 499   2009.3

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    DOI： 10.1038/mt.2008.294

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  • Computer-assisted hydrodynamic gene delivery Reviewed

    Takeshi Suda, Kieko Suda, Dexi Liu

    MOLECULAR THERAPY   16 ( 6 )   1098 - 1104   2008.6

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    DOI： 10.1038/mt.2008.66

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  • A case of hepatic epithelioid hemangioendothelioma with peritoneal dissemination and severe infiltration to the vessels

    KAMIMURA Kenya, YAMAMOTO Takashi, SUDA Takeshi, TAKAHASHI Toru, NOMOTO Minoru, SAKURADA Junko, AOYAGI Yutaka

    Kanzo   49 ( 1 )   14 - 21   2008.1

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    A 54-year-old man was admitted to our hospital with jaundice and abdominal distension. He was pointed out the multiple liver tumors five years ago. During the follow-up period, tumor size showed no remarkable changes, but jaundice and ascites were observed after five years. Further examinations including the peritoneoscopy and biopsy from disseminated lesion in the skin revealed hepatic epithelioid hemangioendothelioma. According to the autopsy, the tumors infiltrated to the hepatic arteries, veins and bile ducts which induced severe deformity of right lobe of the liver and disseminated to ...

    DOI： 10.2957/kanzo.49.14

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  • A new scoring system for predicting survival in patients with hepatocellular carcinoma: The integration of the JIS and CLIP scoring systems. Reviewed

    Kuriko K, Suda T, Igarashi M, Toyabe S, Aoyagi Y, Akazawa K

    Acta medica et biologica   56 ( 2 )   73 - 84   2008

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    Several integrated scoring systems for hepatocellular carcinoma (HCC) have recently been proposed, but there is still no consensus regarding their validity. The present study developed a new scoring system to obtain a better model for predicting the survival of patients with HCC. Data obtained from 1,070 patients with HCC diagnosed at 31 hospitals affiliated with the Niigata Liver Disease Study Group from January 1993 through December 2003 were retrospectively analyzed. The significant factors, which affected the survival of the patients were analyzed, and the best fitting model for the patients' survival was constructed. Fourteen factors were identified based on a univariate analysis, and those factors were used in a multivariate analysis as the candidate prognostic factors. The first Cox's analysis revealed that the Cancer of the Liver Italian Program (CLIP) score, tumor diameter, metastasis (N factor and/or M factor) based on the Liver Cancer Study Group of Japan (LCSGJ), and Japan Integrated Staging (JIS) score were all significant factors. Since the results suggested that both the CLIP and JIS scores were insufficient for the prediction of survival, the Japan Integrated Triform system (JITs) score was designed by removing tumor morphology and portal vein thrombosis from the CLIP score and by adding T factor and metastasis of the LCSGJ. An evaluation by the Akaike information criteria (AIC) showed the JITs score to be a good-fitting model in the present study population. JITs score may hopefully be useful for physicians in determining the appropriate management options.

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    Other Link： http://search.jamas.or.jp/link/ui/2009186907

  • Regular Exercise Improves Insulin Sensitivity, Physical Activity, and Psychosocial Status in Patients with Chronic Liver Diseases. Reviewed

    Kobayashi M, Suda T, Hashiba M, Nagasaki K, Adachi A, Nomoto M, Arakawa M, Aoyagi Y

    Acta Medica et Biologica   56 ( 1 )   1 - 9   2008

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    Limitations to physical activity lead to impairments of insulin sensitivity and deterioration of health related quality of life (HRQOL) in patients with chronic liver diseases (CLD). The effects of regular exercise on physical and psychosocial factors were prospectively evaluated in CLD. Five patients with various etiologies and stages were enrolled. Daily aerobic and resistance trainings were conducted for a course of five months with an oral intake of branched-chain amino acids (BCAA) starting one month prior to the exercise. Various biochemical, physical parameters, and profile of mood states (POMS) were measured before and after the course. Statistical significance was evaluated using a resampling method. No event was marked during the course to require additional treatments. A significant improvement in insulin sensitivity was observed as reductions of fasting blood glucose and serum insulin levels. Physical capability was significantly improved in both strength and endurance as increments of grasping and knee extension powers, and ventilatory threshold. The fatigue score was significantly reduced in accordance with a decreasing tendency of all other negative aspects in POMS. While significant decreases in serum concentrations of cholinesterase and prealbumin, platelet count, and bone mass were observed, serum concentrations of transferrin and BCAA as well as prothrombin activity showed increasing tendency. Regular exercise could be a promising alternative to improve insulin sensitivity and HRQOL in CLD, though medications and close evaluation should be conducted for possibilities of osteoporosis and hemorrhagic events.

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    Other Link： http://search.jamas.or.jp/link/ui/2008231310

  • Fucosylated fraction of alpha-fetoprotein, L3, as a useful prognostic factor in patients with hepatocellular carcinoma with special reference to low concentrations of serum alpha-fetoprotein Reviewed

    Makoto Kobayashi, Takashi Kuroiwa, Takeshi Suda, Yasushi Tamura, Hirokazu Kawai, Masato Igarashi, Yasuo Fukuhara, Yutaka Aoyagi

    HEPATOLOGY RESEARCH   37 ( 11 )   914 - 922   2007.11

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    DOI： 10.1111/j.1872-034X.2007.00147.x

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  • Structural impact of hydrodynamic injection on mouse liver Reviewed

    T. Suda, X. Gao, D. B. Stolz, D. Liu

    GENE THERAPY   14 ( 2 )   129 - 137   2007.1

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    DOI： 10.1038/sj.gt.3302865

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  • A strategy to estimate liver fibrosis level based on vascular-structure analysis in CTAP Reviewed

    M. Ishikawa, H. Uchida, Y. Maeda, M. Yamamoto, M. Igarashi, T. Suda, M. Nomoto, Y. Aoyagi

    Medical Imaging and Information Sciences   23 ( 5 )   130 - 135   2006.12

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    Chronic liver disease causes health problem such as hepatic failure or hepatocellular carcinoma. As the disease progresses, some fibroses become apparent, and, as such, influence a vascular structure. We have proposed, previously, a method to extract various vascular features from CTAP images. In this paper we suggested that the method improved in this paper should be applicable to CTAP images of 9 patients. It reveals that the vascular-structure analysis can be useful for estimating liver fibrosis level.

    DOI： 10.11318/mii.23.130

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    Other Link： http://search.jamas.or.jp/link/ui/2008047878

  • Comparison between human-telomerase reverse transcriptase mRNA and alpha-fetoprotein mRNA as a predictive value for recurrence of hepatocellular carcinoma in living donor liver transplantation Reviewed

    H. Oya, Y. Sato, S. Yamamoto, H. Nakatsuka, T. Kobayashi, Y. Hara, N. Waguri, T. Suda, Y. Aoyagi, K. Hatakeyama

    TRANSPLANTATION PROCEEDINGS   38 ( 10 )   3636 - 3639   2006.12

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    DOI： 10.1016/j.transproceed.2006.10.172

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  • Long-term outcomes of hepatectomy vs percutaneous ablation for treatment of hepatocellular carcinoma &lt;= 4 cm Reviewed

    Toshifumi Wakai, Yoshio Shirai, Takeshi Suda, Naoyuki Yokoyama, Jun Sakata, Pauldion V. Cruz, Hirokazu Kawai, Yasunobu Matsuda, Masashi Watanabe, Yutaka Aoyagi, Katsuyoshi Hatakeyama

    WORLD JOURNAL OF GASTROENTEROLOGY   12 ( 4 )   546 - 552   2006.1

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  • Preoperative human-telomerase reverse transcriptase mRNA in peripheral blood and tumor recurrence in living-related liver transplantation for hepatocellular carcinoma Reviewed

    Y Sato, S Yamamoto, H Oya, H Nakatsuka, T Kobayashi, T Takeishi, K Hirano, Y Hara, T Watanabe, N Waguri, T Suda, T Ichida, Y Aoyagi, K Hatakeyama

    HEPATO-GASTROENTEROLOGY   52 ( 65 )   1325 - 1328   2005.9

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  • Liver metastasis 30 years after enucleation of the left eyeball for choroidal melanoma Reviewed

    N Waguri, A Yoshimura, T Suda, S Yamamoto, T Kamura, M Igarashi, N Honma, T Takahashi, M Nomoto, M Yamamoto, Y Aoyagi

    HEPATOLOGY RESEARCH   30 ( 4 )   232 - 237   2004.12

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    DOI： 10.1016/j.hepres.2004.10.007

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  • Increased hTR expression during transition from adenoma to carcinoma is not associated with promoter methylation Reviewed

    A Nakamura, T Suda, T Honma, T Takahashi, M Igarashi, N Waguri, H Kawai, Y Mita, Y Aoyagi

    DIGESTIVE DISEASES AND SCIENCES   49 ( 9 )   1504 - 1512   2004.9

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    DOI： 10.1023/B:DDAS.0000042256.89282.c4

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  • [Detection of HDV-RNA]. Reviewed

    Suda T, Ohkoshi S, Aoyagi Y

    Nihon rinsho. Japanese journal of clinical medicine   62 Suppl 8   416 - 419   2004.8

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  • Studies on the correlation among the fucosylation index, concentration of alpha-fetoprotein and des-gamma-carboxy prothrombin as prognostic indicators in hepatocellular carcinoma Reviewed

    H Igarashi, Y Aoyagi, T Suda, Y Mita, K Kawai

    HEPATOLOGY RESEARCH   27 ( 4 )   279 - 287   2003.12

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  • Interferon can block telomere erosion and in rare cases result in hepatocellular carcinoma development with telomeric repeat binding factor 1 overexpression in chronic hepatitis C Reviewed

    M Igarashi, T Suda, H Hara, M Takimoto, M Nomoto, T Takahashi, S Okoshi, H Kawai, Y Mita, N Waguri, Y Aoyagi

    CLINICAL CANCER RESEARCH   9 ( 14 )   5264 - 5270   2003.11

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  • Sensitive and specific detection of circulating cancer cells in patients with hepatocellular carcinoma; Detection of human telomerase reverse transcriptase messenger RNA after immunomagnetic separation Reviewed

    N Waguri, T Suda, M Nomoto, H Kawai, Y Mita, T Kuroiwa, M Igarashi, M Kobayashi, Y Fukuhara, Y Aoyagi

    CLINICAL CANCER RESEARCH   9 ( 8 )   3004 - 3011   2003.8

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  • Telomere length variation and maintenance in hepatocarcinogenesis Reviewed

    T Yokota, T Suda, M Igarashi, T Kuroiwa, N Waguri, H Kawai, Y Mita, Y Aoyagi

    CANCER   98 ( 1 )   110 - 118   2003.7

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    DOI： 10.1002/cncr.11428

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  • Remote development of hepatocellular carcinoma in patients with liver cirrhosis type B serologically cured for HBs antigenemia with long-standing normalization of ALT values Reviewed

    S Okoshi, M Igarashi, T Suda, H Iwamatsu, K Watanabe, K Ishihara, N Ogata, M Nomoto, T Takahashi, T Ichida, H Asakura, K Nihei, Kurosaki, I

    DIGESTIVE DISEASES AND SCIENCES   47 ( 9 )   2002 - 2006   2002.9

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    DOI： 10.1023/A:1019608509402

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  • The fucosylation index of serum alpha-fetoprotein as useful prognostic factor in patients with hepatocellular carcinoma in special reference to chronological changes Reviewed

    Y Aoyagi, Y Mita, T Suda, K Kawai, T Kuroiwa, M Igarashi, M Kobayashi, N Waguri, H Asakura

    HEPATOLOGY RESEARCH   23 ( 4 )   287 - 295   2002.8

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    DOI： 10.1016/S1386-6346(01)00184-X

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  • Bile duct involvement in a case of autoimmune pancreatitis successfully treated with an oral steroid Reviewed

    T Kuroiwa, T Suda, T Takahashi, H Hirono, M Natsui, H Motoyama, M Nomoto, Y Aoyagi

    DIGESTIVE DISEASES AND SCIENCES   47 ( 8 )   1810 - 1816   2002.8

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    DOI： 10.1023/A:1016452813815

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  • Heterogeneous hepatic enhancement on CT angiography in idiopathic portal hypertension Reviewed

    N Waguri, T Suda, T Kamura, Y Aoyagi

    LIVER   22 ( 3 )   276 - 280   2002.6

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    DOI： 10.1046/j.0106-9543.2002.01663.x

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  • Interchromosomal telomere length variation Reviewed

    T Suda, A Fujiyama, M Takimoto, M Igarashi, T Kuroiwa, N Waguri, H Kawai, Y Mita, Y Aoyagi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   291 ( 2 )   210 - 214   2002.2

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    DOI： 10.1006/bbrc.2002.6425

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  • N-Acetylglucosaminyltransferase V as a possible aid for the evaluation of tumor invasiveness in patients with hepatocellular carcinoma Reviewed

    M Yanagi, Y Aoyagi, T Suda, Y Mita, H Asakura

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   16 ( 11 )   1282 - 1289   2001.11

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    DOI： 10.1046/j.1440-1746.2001.02612.x

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  • Diagnosis of pancreatic adenocarcinoma by detection of human telomerase reverse transcriptase messenger RNA in pancreatic juice with sample qualification Reviewed

    K Seki, T Suda, Y Aoyagi, S Sugawara, M Natsui, H Motoyama, Y Shirai, T Sekine, H Kawai, Y Mita, N Waguri, T Kuroiwa, M Igarashi, H Asakura

    CLINICAL CANCER RESEARCH   7 ( 7 )   1976 - 1981   2001.7

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    DOI： 10.1177/153331750101600512

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  • Clinical features and etiology of hepatocellular carcinoma arising in patients with membranous obstruction of the inferior vena cava: In reference to hepatitis viral infection Reviewed

    S Matsui, T Ichida, M Watanabe, S Sugitani, T Suda, T Takahashi, H Asakura

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   15 ( 10 )   1205 - 1211   2000.10

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    DOI： 10.1046/j.1440-1746.2000.02303.x

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  • Plasma fucosyltransferase activity in patients with hepatocellular carcinoma, with special reference to correlation with fucosylated species of alpha-fetoprotein Reviewed

    Y Mita, Y Aoyagi, T Suda, H Asakura

    JOURNAL OF HEPATOLOGY   32 ( 6 )   946 - 954   2000.6

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    DOI： 10.1016/S0168-8278(00)80099-9

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  • Quantitative evaluation of genomic instability as a possible predictor for development of hepatocellular carcinoma: Comparison of loss of heterozygosity and replication error Reviewed

    H Kawai, T Suda, Y Aoyagi, O Isokawi, Y Mita, N Waguri, T Kuroiwa, M Igarashi, K Tsukada, S Mori, T Shimizu, Y Suzuki, Y Abe, T Takahashi, M Nomoto, H Asakura

    HEPATOLOGY   31 ( 6 )   1246 - 1250   2000.6

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    DOI： 10.1053/jhep.2000.7298

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  • Elevation of TFF1 gene expression during healing of gastric ulcer at non-ulcerated sites in the stomach: Semiquantification using the single tube method of polymerase chain reaction Reviewed

    T Saitoh, T Mochizuki, T Suda, Y Aoyagi, Y Tsukada, R Narisawa, H Asakura

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   15 ( 6 )   604 - 609   2000.6

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    DOI： 10.1046/j.1440-1746.2000.02209.x

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  • Asymptomatic primary sclerosing cholangitis with marked hepatic fibrosis Reviewed

    H Kawai, Y Aoyagi, M Nomoto, H Takizawa, Y Suzuki, A Hama, T Suda, T Takahashi, H Asakura

    DIGESTIVE DISEASES AND SCIENCES   45 ( 4 )   680 - 684   2000.4

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    DOI： 10.1023/A:1005427223036

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  • The striking effect of hyperbaric oxygenation therapy in the management of chronic idiopathic intestinal pseudo-obstruction Reviewed

    T Yokota, T Suda, S Tsukioka, T Takahashi, T Honma, K Seki, J Matsuzawa, M Miura, Y Aoyagi, H Asakura

    AMERICAN JOURNAL OF GASTROENTEROLOGY   95 ( 1 )   285 - 288   2000.1

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    DOI： 10.1016/S0002-9270(99)00769-8

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  • Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: Convenient evaluation by slot-blot analysis Reviewed

    O Isokawa, T Suda, Y Aoyagi, H Kawai, T Yokota, T Takahashi, K Tsukada, T Shimizu, S Mori, Y Abe, Y Suzuki, M Nomoto, Y Mita, M Yanagi, H Igarashi, H Asakura

    HEPATOLOGY   30 ( 2 )   408 - 412   1999.8

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    DOI： 10.1002/hep.510300211

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  • A Pregnant Case of Severe Acute Hepatitis Type C Successfully Treatedwith Natural Interferon-Alpha and Showing No Evidence of a Maternal Transmission of HCV to the Newborn. Reviewed

    Suda T, Ohokoshi, S Aoyagi Y, Fujimaki T, Narisawa R, Nomoto M, Kamimura T, Tanaka K, Asakura H

    Acta medica et biologica   47 ( 2 )   75 - 80   1999

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    We report here a case of a 21-year-old Japanese woman suffering from severe acute liver injury due to hepatitis C virus (HCV) infection in the third trimester of her first pregnancy. When a second-generation antibody reactivity to HCV had not yet appeared, HCV RNA was detected in her serum using a polymerase chain reaction. Subsequent natural interferon-alpha therapy played a key role in the recovery from severe hepatic injury, and the disappearance of HCV RNA in her serum. Consequently, HCV RNA has not been detected for over 17 months after the cessation of interferon administration. On the other hand HCV RNA was not detected in her cord or the baby serum. Therefore, maternal transmission of HCV was not evidenced. This is a rare case in which a severe form of acute hepatitis C was successfully treated with natural interferon-alpha, and no indication of a maternal transmission of HCV in acute hepatitis C could be demonstrated with polymerase chain reaction analysis.

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    Other Link： http://search.jamas.or.jp/link/ui/2000027984

  • The fucosylation index of alpha-fetoprotein as a possible prognostic indicator for patients with hepatocellular carcinoma Reviewed

    Y Aoyagi, O Isokawa, T Suda, M Watanabe, Y Suzuki, H Asakura

    CANCER   83 ( 10 )   2076 - 2082   1998.11

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  • The usefulness of determining des-gamma-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma Reviewed

    Y Mita, Y Aoyagi, M Yanagi, T Suda, Y Suzuki, H Asakura

    CANCER   82 ( 9 )   1643 - 1648   1998.5

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  • Quantitation of telomerase activity in hepatocellular carcinoma: A possible aid for a prediction of recurrent diseases in the remnant liver Reviewed

    T Suda, O Isokawa, Y Aoyagi, M Nomoto, K Tsukada, T Shimizu, Y Suzuki, A Naito, H Igarashi, M Yanagi, T Takahashi, H Asakura

    HEPATOLOGY   27 ( 2 )   402 - 406   1998.2

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    DOI： 10.1002/hep.510270213

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  • Telomerase activity and metastasis: Expansion of cells having higher telomerase activity within culture lines and tumor tissues Reviewed

    Y Saito, S Kosugi, T Suda, Y Wakabayashi, Y Mishima, K Hatakeyama, R Kominami

    JAPANESE JOURNAL OF CANCER RESEARCH   88 ( 8 )   732 - 737   1997.8

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  • Measurement of the fucosylated sugar chins of serum alpha-1-antitrypisn: the relationship between reactivity with Lens culinaris agglutinin and HPLC analysis of the pyridylaminated sugar chins. Reviewed

    Saitoh A, Aoyagi Y, Mori S, Suda T, Suzuki Y, Sekine C, Asakura H

    Acta Medica et Biologica   45 ( 1 )   11 - 14   1997

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    Other Link： http://search.jamas.or.jp/link/ui/1997187668

  • A novel activity of HMG domains: Promotion of the triple-stranded complex formation between DNA containing (GGA/TCC)(11) and d(GGA)(11) oligonucleotides Reviewed

    T Suda, Y Mishima, K Takayanagi, H Asakura, S Odani, R Kominami

    NUCLEIC ACIDS RESEARCH   24 ( 23 )   4733 - 4740   1996.12

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    DOI： 10.1093/nar/24.23.4733

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  • Alpha-fetoprotein-producing renal cell carcinoma with increased activity of N-acetylglucosaminyltransferase III Reviewed

    Y Aoyagi, S Mori, A Naitoh, M Yanagi, Y Suzuki, T Suda, O Isokawa, H Igarashi, T Takahashi, M Isemura, H Asakura

    NEPHRON   74 ( 2 )   409 - 414   1996.10

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  • Clinical significance of simultaneous determinations of alpha-fetoprotein and des-gamma-carboxy prothrombin in monitoring recurrence in patients with hepatocellular carcinoma Reviewed

    Y Aoyagi, M Oguro, M Yanagi, Y Mita, T Suda, Y Suzuki, K Hata, K Ichii, H Asakura

    CANCER   77 ( 9 )   1781 - 1786   1996.5

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  • Microheterogeneity of serum transferrin in the diagnosis of hepatocellular carcinoma Reviewed

    Y Suzuki, Y Aoyagi, S Mori, T Suda, A Naitoh, O Isokawa, M Yanagi, H Igarashi, H Asakura

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   11 ( 4 )   358 - 365   1996.4

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  • Formation of a triple-stranded DNA between d(GGA:TCC) repeats and d(GGA) repeat oligonucleotides Reviewed

    Y Mishima, T Suda, R Kominami

    JOURNAL OF BIOCHEMISTRY   119 ( 4 )   805 - 810   1996.4

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  • Formation of a parallel-stranded DNA homoduplex by d(GGA) repeat oligonucleotides. Reviewed

    Takeshi Suda, Yukio Mishima, Hitoshi Asakura, Ryo Kominami

    Nucleic Acids Research   23 ( 18 )   3771 - 3777   1996.3

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    DOI： 10.1093/nar/23.18.3771

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  • Microheterogeneity analysis of serum transferrin before and after therapies to hepatocellular carcinoma Reviewed

    Y Suzuki, Y Aoyagi, A Naitoh, O Isokawa, H Igarashi, M Yanagi, T Suda, S Mori, H Asakura

    INTERNATIONAL HEPATOLOGY COMMUNICATIONS   4 ( 4 )   190 - 194   1995.12

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  • FORMATION OF A PARALLEL-STRANDED DNA HOMODUPLEX BY D(GGA) REPEAT OLIGONUCLEOTIDES Reviewed

    T SUDA, Y MISHIMA, H ASAKURA, R KOMINAMI

    NUCLEIC ACIDS RESEARCH   23 ( 18 )   3771 - 3777   1995.9

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    DOI： 10.1093/nar/23.18.3771

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  • NUTRITIONAL SUPPORT THROUGH PERCUTANEOUS TRANSHEPATIC INTERNAL DRAINAGE ROUTE IN COMMON BILE-DUCT CANCER Reviewed

    T SUDA, T OZAWA, Y AOYAGI, S MORI, M WATANABE, Y TSUKADA, T KAMIMURA, H ASAKURA

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   9 ( 5 )   524 - 526   1994.9

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  • SEQUENCE-ANALYSIS OF THE PROXIMAL PROMOTER REGION OF THE HUMAN ALPHA-FETOPROTEIN GENE IN HEPATOCELLULAR-CARCINOMA Reviewed

    K IGARASHI, Y AOYAGI, S OHKOSHI, T YOKOTA, S MORI, T SUDA, T KAMIMURA, H ASAKURA

    CANCER LETTERS   76 ( 2-3 )   93 - 99   1994.1

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  • Novel mouse microsatellites: Primer sequences and chromosomal location Reviewed

    Takeshi Suda, Mitsuru Oyanagi, Shigeharu Wakana, Yoshiaki Takahashi, Hideki Kanada, Hiromichi Yonekawa, Nobumoto Miyashita, Toshihiko Shiroishi, Kazuo Moriwaki, Ryo Kominami

    DNA Research   1 ( 4 )   169 - 174   1994

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    DOI： 10.1093/dnares/1.4.169

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  • HIGHLY ENHANCED FUCOSYLATION OF ALPHA-FETOPROTEIN IN PATIENTS WITH GERM-CELL TUMOR Reviewed

    Y AOYAGI, Y SUZUKI, K IGARASHI, T YOKOTA, S MORI, T SUDA, A NAITOH, M ISEMURA, H ASAKURA

    CANCER   72 ( 2 )   615 - 618   1993.7

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  • CARBOHYDRATE STRUCTURES OF HUMAN ALPHA-FETOPROTEIN OF PATIENTS WITH HEPATOCELLULAR-CARCINOMA - PRESENCE OF FUCOSYLATED AND NONFUCOSYLATED TRIANTENNARY GLYCANS Reviewed

    Y AOYAGI, Y SUZUKI, K IGARASHI, A SAITOH, M OGURO, T YOKOTA, S MORI, T SUDA, M ISEMURA, H ASAKURA

    BRITISH JOURNAL OF CANCER   67 ( 3 )   486 - 492   1993.3

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  • STRUCTURAL-ANALYSIS ON THE SUGAR CHAINS OF ALPHA(1)-ANTITRYPSIN FROM PATIENTS WITH HEPATOCELLULAR-CARCINOMA Reviewed

    A SAITOH, Y AOYAGI, M OGURO, K IGARASHI, T YOKOTA, S MORI, T SUDA, Y SUZUKI, C SEKINE, T KAMIMURA, H ASAKURA

    INTERNATIONAL HEPATOLOGY COMMUNICATIONS   1 ( 1 )   5 - 10   1993.3

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  • FUCOSYLATION INDEX OF ALPHA-FETOPROTEIN, A POSSIBLE AID IN THE EARLY RECOGNITION OF HEPATOCELLULAR-CARCINOMA IN PATIENTS WITH CIRRHOSIS Reviewed

    Y AOYAGI, A SAITOH, Y SUZUKI, K IGARASHI, M OGURO, T YOKOTA, S MORI, T SUDA, M ISEMURA, H ASAKURA

    HEPATOLOGY   17 ( 1 )   50 - 52   1993.1

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  • [Genome analysis of mice]. Reviewed

    Kominami R, Takahashi Y, Kuwabara K, Hayashi T, Koyanagi M, Suda T, Mafune Y, Kaneda H, Yonekawa H, Wakana S

    Tanpakushitsu Kakusan Koso   38   696 - 703   1993

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  • A case of biloma induced by spontaneous rupture of gallbladder.

    SUDA Takeshi, OYA Minoru, HATAKEYAMA Sigeaki, ABE Atushi, SAITO Hideaki, TAKAGI Kentaro, KOYAMA Takanobu, SEKIYA Masao

    Nippon Shokakibyo Gakkai Zasshi   88 ( 6 )   1375 - 1379   1991

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    DOI： 10.11405/nisshoshi1964.88.1375

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    Other Link： http://search.jamas.or.jp/link/ui/1992074481

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Books

  • Gene Therapy and Cell Therapy Through the Liver

    Kamimura K, Suda T, Kanefuji T, Yokoo T, Abe H, Kobayashi Y, Aoyagi Y, Liu D（ Role： Joint author）

    Springer  2015  （ ISBN:9784431556657 ）

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  • Advances and Challenges in the Delivery of Nucleic Acid Therapeutics (Volume 2)

    Kamimura K, Suda T, Liu D（ Role： Joint author）

    Future Medicine  2015 

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  • Gene Therapy and Cell Therapy Through the Liver

    S Terai, T Suda（ Role： Joint editor）

    Springer  2015  （ ISBN:9784431556657 ）

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  • Advanced Textbook on Gene Transfer

    Suda T, Kamimura K, Zhang G, Liu D（ Role： Joint author）

    Imperial College Press  2013  （ ISBN:9781848168282 ）

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  • Pharmaceutical Medicine

    Kamimura K, Suda T, Zhang G, Liu D（ Role： Joint author）

    Springer  2011 

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  • Concepts in genetic medicine

    Suda T, Liu D（ Role： Joint author）

    A John Wiley & Sons, Inc.  2008  （ ISBN:9780471703204 ）

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  • Genetics in Wild Mice

    Wakana S, Shiroishi T, Miyashita N, Moriwaki K, Kaneda H, Okamoto M, Yonekawa H, Suda T, Oyanagi I, Kominami R（ Role： Joint author）

    KARGER  1994  （ ISBN:9783805560542 ）

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MISC

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Presentations

  • 音響放射圧を用いた肝硬度測定の標準化に向けた取り組み

    窪田智之, 兼藤努, 須田剛士

    日本肝臓学会東部会  2018.12 

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  • Endoscopic transpapillary biliary biopsy using the sheath of a plastic stent International conference

    Shinichi Morita, Itsuo Nagayama, Takahiro Hoshi, Satoshi Abe, Tsutomu Kanefuji, Kazuyoshi Yagi, Takeshi Suda, Shuji Terai

    アジア太平洋消化器関連学会週間  2018.11 

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  • A gravity-assisted liver stiffness measurement International conference

    Itsuo Nagayama, Takeshi Suda, Tsutomu Kanefuji, Takahiro Hoshi, Satoshi Abe, Shinichi Morita, Kazuyoshi Yagi, Shuji Terai

    アジア太平洋消化器関連学会週間  2018.11 

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  • NAFLDにおける肝細胞癌発がんの特徴

    須田剛士, 兼藤努, 小田知友美, 星隆洋, 森田慎一, 八木一芳, 寺井崇二

    日本消化器関連学会週間  2018.11 

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  • 健診におけるNASH拾い上げのための肝硬度の閾値設定と、肝硬度からみたNAFLD肝癌の特徴

    須田剛士, 兼藤努, 阿部惇, 小田知友美, 星隆洋, 森田慎一, 八木一芳, 寺井崇二

    日本肝癌研究会  2018.6 

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  • うっ血病態における肝線維化進展指標の確立

    須田剛士, 佐藤俊大, 寺井崇二

    日本肝臓学会総会  2018.6 

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  • 非アルコール性脂肪肝炎候補者の選別と、肥満と独立した特徴の抽出

    須田剛士, 兼藤努, 永山逸夫, 星隆洋, 阿部聡司, 森田慎一, 八木一芳, 阿部惇, 寺井崇二

    日本消化器病学会総会  2018.4 

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  • A rational arrangement of measuring shear wave speed in the liver evoked by acoustic radiation force impulse International conference

    Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Naruhiro Kimura, Toru Sestu, Akira Sakamaki, Hiroteru Kamimura, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Shuji Terai

    米国肝臓学会議  2018 

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  • 切除不能消化器癌の予後に対するサルコペニア関連因子の影響

    兼藤努, 小田知友美, 星隆洋, 森田慎一, 須田剛士, 八木一芳, 寺井崇二

    日本消化器病学会総会  2018 

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  • Advancement of percutaneous abscess drainage in safety; US-guidance with real-time image fusion International conference

    Morita S, Hoshi T, Kanefuji T, Kobayashi M, Suda T, Terai S

    日本インターベンショナルラジオロジー学会  2018 

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  • 腹腔内膿瘍に対する各種画像modality用いたドレナージ術の検討

    森田慎一, 小田知友美, 星隆洋, 兼藤努, 八木一芳, 須田剛士, 寺井崇二

    日本消化器病学会総会  2017.10 

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  • 健診コホートを対象としたNASH拾い上げ手法の確立

    兼藤努, 須田剛士, 寺井崇二

    日本消化器関連学会週間  2017.10 

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  • 既存電子カルテの運用対応によるHBV再活性化対策の有用性と問題点

    須田剛士, 兼藤努, 寺井崇二

    日本消化器関連学会週間  2017.10 

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  • Endoscopic ultrasound-guided transmural drainage for a postoperative intraabdominal abscess International conference

    Morita S, Oda C, Hoshi T, Kanefuji T, Suda T, Terai S

    消化器インターベンション医学会  2017.9 

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  • 人間ドックでいかに非アルコール性脂肪肝炎を絞り込むか Invited

    須田剛士

    日本人間ドック学会学術大会  2017.8 

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  • Budd-Chiari 症候群を呈した肝単包虫症（Hepatic cystic echinococcosis）の一例

    森田慎一, 小田知友美, 星隆洋, 兼藤努, 小林正明, 八木一芳, 須田剛士, 平野謙一郎, 小杉伸一, 長谷川剛, 迫康仁, 寺井崇二

    日本臨床寄生虫学会総会  2017.6 

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  • Successful interventional drainage of subphrenic abscesses after intra-abdominal surgery International conference

    Morita S, Hoshi T, Kanefuji T, Kobayashi M, Suda T, Ikeda Y, Terai S

    日本インターベンショナルラジオロジー学会  2017.5 

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  • Dexmedetomidine-based sedation during EUS for elderly patients

    Morita S, Hoshi T, Kanefuji T, Kobayashi M, Suda T, Terai S

    日本消化器内視鏡学会  2017.5 

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  • 健診受診者における肝硬度の分布に基づくNASH高リスク食餌因子同定の試み

    須田剛士, 兼藤努, 小田知友美, 星隆洋, 森田慎一, 小林正明, 八木一芳, 阿部惇, 寺井崇二

    日本消化器病学会総会  2017.4 

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  • Platinum-based transhepatic arterial chemotherapy using a combination of miriplatin and CDDP powder in patients with hepatocellular carcinoma. International conference

    Ogawa K, Kamimura K, Yokoo T, Sakamaki A, Abe S, Kamimura H, Tsuchiya A, Takamura M, Kawai H, Waguri N, Ishikawa T, Yamagiwa S, Suda T, Terai S

    米国肝臓学会議  2016.11 

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  • A flow deviation of the superior mesenteric vein in the liver fits pathological progression/alleviation of nonalcoholic steatohepatitis. International conference

    Suda T, Kanefuji T, Hoshi T, Morita S, Kobayashi M, Terai S

    アジア太平洋消化器関連学会週間  2016.11 

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  • Dexmedetomidine-based sedation during ERCP for elderly patients. International conference

    Morita S, Hoshi T, Kanefuji T, Kobayashi M, Suda T, Terai S

    アジア太平洋消化器関連学会週間  2016.11 

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  • 進行肝細胞癌に対するアイエーコールとミリプラの併用肝動注療法の意義・多施設共同研究による第II相試験

    上村顕也, 横尾健, 坂牧僚, 阿部聡司, 上村博輝, 兼藤努, 土屋淳紀, 高村昌昭, 川合弘一, 山際訓, 須田剛士, 寺井崇二

    日本消化器関連学会週間  2016.11 

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  • せん断弾性波速度（SWV）測定がウイルス制御下時代の発癌リスクアセスメントに対して果たす役割

    兼藤努, 須田剛士, 寺井崇二

    日本消化器関連学会週間  2016.11 

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  • 肝硬度測定の標準化に向けて

    須田剛士, 兼藤努, 寺井崇二

    日本消化器関連学会週間  2016.11 

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  • 超音波を用いたメタボリックシンドロームへのアプローチ Invited

    須田剛士

    日本超音波医学会関東甲信越地方会  2016.10 

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  • Percutaneous gastrostomy through a reconstructed gastric tube after esophagectomy. International conference

    Morita S, Arai Y, Tomita K, Sugawara S, Sone M

    消化器インターベンション医学会  2016.10 

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  • 傍臍静脈-大循環シャントと脾機能亢進症を伴う巨脾症例の術前に、脾動脈一時閉塞下門脈血流 評価を成し得た一例

    兼藤努, 星隆洋, 森田慎一, 小林正明, 須田剛士, 寺井崇二

    日本門脈圧亢進症学会総会  2016.9 

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  • メタボ時代の肝細胞がんスクリーニング. Invited

    須田剛士

    日本消化器癌検診学会  2016.8 

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  • 音響放射圧により惹起される肝内せん断弾性波速度の測定方法に基づく特徴

    須田剛士, 兼藤努, 星隆洋, 森田慎一, 小林正明, 阿部惇, 横尾健, 上村顕也, 土屋淳紀, 高村昌昭, 川合弘一, 山際訓, 寺井崇二

    日本肝臓学会総会  2016.5 

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  • Share wave velocity (SWV) fits the risk assessment of hepatocellular carcinoma (HCC) development especially in nonalcoholic fatty liver disease (NAFLD). International conference

    Atsunori Tsuchiya, Kenya Kamimura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    アジア太平洋肝臓学会  2016.2 

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  • Value of shear wave velocity measurements for the risk assessment of hepatocellular carcinoma development in patients with viral hepatitis International conference

    Masaaki Takamura, Tsutomu Kanefuji, Takeshi Suda, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, Kenya Kamimura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    アジア太平洋肝臓学会  2016.2 

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  • H. pylori除菌後発見胃癌に対する遡及的検討

    小林正明, 佐藤祐一, 寺井崇二

    日本消化器関連学会週間  2015.10 

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  • 先天性心疾患における器質的な肝障害に関連する因子の同定

    須田剛士, 杉本愛, 兼藤努, 横尾健, 上村博輝, 上村顕也, 土屋淳紀, 高村昌昭, 川合弘一, 山際訓, 白石修一, 渡邉マヤ, 文智勇, 高橋昌, 寺井崇二

    日本消化器関連学会週間  2015.10 

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  • 肝細胞癌の予後に影響する栄養学因子

    兼藤努, 須田剛士, 横尾健, 上村博輝, 上村顕也, 土屋淳紀, 高村昌昭, 川合弘一, 山際訓, 寺井崇二

    日本消化器関連学会週間  2015.10 

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  • Percutaneous side-by-side stents placement for malignant hilar biliary strictures. International conference

    Morita S, Arai Y, Sone M, Ishii H, Sugawara S, Setsu T, Hoshi T, Kanefuji T, Kobayashi M, Suda T

    消化器インターベンション医学会  2015.10 

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  • 担癌肝硬変における腫瘍因子・肝予備能以外の予後規定因子

    兼藤努, 須田剛士, 寺井崇二

    日本肝臓学会総会  2015.5 

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  • Gd-EOB-DTPA-MRIによる非多血化結節の拾い上げと介入適応判定による早期肝細胞癌へのアプローチ

    須田剛士, 兼藤努, 寺井崇二

    日本肝臓学会総会  2015.5 

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  • Virtual Touch® Quantificationによる肝硬度測定における伝搬速度の測定部位ならびに測定ポイント数の検討

    横尾健, 兼藤努, 須田剛士, 上村博輝, 上村顕也, 土屋淳紀, 高村昌昭, 川合弘一, 山際訓, 寺井崇二

    日本肝臓学会総会  2015.5 

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  • 血清APM2濃度は、プラチナ系抗腫瘍剤の治療効果予測のバイオマーカーとして有用である

    上村顕也, 須田剛士, 阿部寛幸, 川合弘一, 青柳豊

    日本肝臓学会総会  2015.5 

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  • Imaging-guided Hydrodynamic Gene Delivery Toward Clinical Trial Invited International conference

    Takeshi Suda

    全米遺伝子細胞治療学会  2015.5 

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  • NAFLD 症例における肝内せん弾波伝搬速度測定の特徴

    横尾健, 須田剛士, 上村博輝, 兼藤努, 上村顕也, 土屋淳紀, 高村昌昭, 川合弘一, 山際訓, 寺井崇二

    肥満と消化器疾患研究会  2015.4 

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  • 鰹だしの末梢血流増加作用は手足症候群の予防に寄与する

    上村顕也, 須田剛士, 阿部寛幸, 川合弘一, 青柳豊

    日本内科学会総会  2015.4 

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  • 当科における門脈圧亢進症を伴った骨髄増殖性疾患症例の臨床的特徴と予後に関する検討

    清野智, 川合弘一, 横尾健, 兼藤努, 上村博輝, 上村顕也, 土屋淳紀, 高村昌昭, 山際訓, 須田剛士, 野本実, 寺井崇二

    日本消化器病学会総会  2015 

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  • 当科と関連施設に於けるC型慢性肝炎に対するIFN治療後発癌の現状

    薛徹, 山際訓, 横尾健, 上村博輝, 兼藤努, 上村顕也, 土屋淳紀, 高村昌昭, 川合弘一, 須田剛士, 石川達, 阿部聡司, 吉田俊明, 寺井崇二

    日本消化器病学会総会  2015 

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  • 慢性腎臓病合併肝細胞癌の予後解析

    木村成宏, 川合弘一, 上村博輝, 兼藤努, 土屋淳紀, 上村顕也, 高村昌昭, 山際訓, 須田剛士, 野本実, 寺井崇二

    日本消化器病学会総会  2015 

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  • Drug-eluting beadsの調整法の検討

    横尾健, 兼藤努, 須田剛士, 上村博輝, 上村顕也, 土屋淳紀, 高村昌昭, 川合弘一, 山際訓, 寺井崇二

    日本消化器病学会総会  2015 

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  • Shear Wave (SW) とVirtual Touch Tissue Quantification (VTTQ) の相関性に基づいたせん断弾性波速度 (SWV) 方式肝硬度測定における適正測定回数の検討

    兼藤努, 須田剛士, 川合弘一, 横尾健, 上村博輝, 上村顕也, 土屋淳紀, 高村昌昭, 山際訓, 野本実

    日本消化器病学会総会  2015 

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  • Impact of injection volume on hydrodynamic injection to the liver in mice International conference

    Tsutomu Kanefuji, Takeshi Yokoo, Takeshi Suda, Kunihiko Sawada, Yoshinori Arai, Hiroyuki Abe, Kenya Kamimura, Dexi Liu, Shuji Terai

    全米遺伝子細胞治療学会  2015 

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  • Rheological modification of hydrodynamic gene delivery. International conference

    Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Akiomi Ushida, Tomiichi Hasegawa, Kenya Kamimura, Dexi Liu, Shuji Terai

    全米遺伝子細胞治療学会  2015 

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  • 肝細胞癌に対するミリプラとアイエーコール肝動注の併用効果に関する検討

    上村顕也, 須田剛士, 青柳豊

    日本消化器関連学会週間  2014.10 

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  • NASH候補判別基準策定におけるVirtual Touch Tissue Quantification (VTTQ) の有用性

    須田剛士, 兼藤努, 石川達

    日本消化器関連学会週間  2014.10 

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  • HBV再活性化 致死的医療過誤回避のためのストラテジー Invited

    須田剛士

    中部リウマチ学会  2014.8 

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  • 非アルコール性脂肪肝疾患の病態進展における2型糖尿病の存在意義

    須田剛士, 廣瀬奏恵, 高村昌昭, 兼藤努, 横尾健, 上村博輝, 土屋淳紀, 上村顕也, 川合弘一, 山際訓, 野本実

    肝臓と糖尿病学会会  2014.7 

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  • Value of shear wave velocity measurements for the risk assessment of hepatocellular carcinoma development in patients with NAFLD International conference

    Takeshi Suda, Masaaki Takamura, Tsutomu Kanefuji, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, Kenya Kamimura, Hirokazu Kawai, Satoshi Yamagiwa, Minoru Nomoto

    国際京都肝癌シンポジウム  2014.6 

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  • 部分的脾動脈塞栓術後の血小板数予測

    須田剛士

    新技術説明会  2014.6 

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  • Overexpression of Matrix Metalloproteinase-13 Gene by the Method of Hydrodynamic Gene Delivery Prevents Liver Fibrosis in Rats International conference

    Hiroyuki Abe, Kenya Kamimura, Takeshi Yokoo, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Dexi Liu, Yutaka Aoyagi

    全米遺伝子細胞治療学会  2014.5 

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  • 右心負荷が肝硬度に与える影響とその測定意義

    杉本 愛, 須田剛士, 高橋昌, 白石修一, 渡邉マヤ, 文智勇, 土田正則

    胸部外科学会  2014 

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  • エネルギー代謝状態によるNAFLDの病態選別と治療候補分子の動態評価

    須田剛士, 横尾健, 兼藤努, 上村博輝, 上村顕也, 土屋淳紀, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 野本実, 青柳豊

    日本消化器病学会総会  2014 

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  • APM2は肝細胞癌のCDDP耐性に関与する

    上村 顕也, 須田 剛士, 阿部 寛幸, 野本 実, 青柳 豊

    日本内科学会総会  2014 

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  • ソラフェニブの手足症候群に対する、かつおぶしだしの有効性の検証

    上村顕也, 須田剛士, 上村博輝, 兼藤努, 土屋淳紀, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 野本実, 青柳豊

    日本肝臓学会総会  2014 

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  • NAFLDからのNASHの抽出における糖尿病合併の重要性

    兼藤努, 須田剛士, 青柳豊

    日本肝臓学会総会  2014 

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  • 高齢肝細胞癌症例に対する個別化医療における非蛋白呼吸商 (npRQ) 測定の有用性

    兼藤努, 須田剛士, 青柳豊

    日本消化器病学会総会  2014 

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  • 新WHO分類に基づく混合型肝癌再分類でのAFP-L3, 臨床経過の違いの考察

    土屋淳紀, 小島雄一, 安住基, 横尾健, 山本幹, 上村博輝, 兼藤努, 上村顕也, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 須田剛士, 野本実, 青柳豊

    日本消化器病学会総会  2014 

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  • ハイドロダイナミック遺伝子導入法によるラット肝硬変モデルの遺伝子治療

    阿部寛幸, 上村顕也, 大塚正人, 横尾健, 三浦浩美, 兼藤努, 須田剛士, 青柳豊

    日本消化器病学会総会  2014 

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  • Hemodynamics of hydrodynamic injection in mouse International conference

    Takeshi Suda, Regis Vollmer, Dexi Liu

    全米遺伝子細胞治療学会  2014 

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  • Parameters for Optimal Hydrodynamic Gene Delivery to Pig Liver Using an Image-guided and Lobe-specific Procedure International conference

    Kenya Kamimura, Takeshi Suda, Hiroyuki Abe, Takeshi Yokoo, Tsutomu Kanefuji, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu

    全米遺伝子細胞治療学会  2014 

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  • 超音波診断装置を用いた肝の弾性診断「肝硬度」は肝うっ血に影響される

    杉本 愛, 高橋昌, 須田剛士, 白石修一, 渡邉マヤ, 土田正則

    小児循環器学会  2014 

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  • 新規ハイドロダイナミック遺伝子導入システムの確立と有用性の検証

    横尾健, 上村顕也, 須田剛士, 兼藤努, 尾田雅文, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 野本実, D.Liu, 青柳豊

    日本消化器関連学会週間  2013.10 

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  • 非アルコール性脂肪性肝疾患におけるIrisinの臨床的な意義

    横尾健, 須田剛士, 青柳豊

    日本消化器関連学会週間  2013.10 

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  • 切除不能肝細胞癌に対するTACEとTOCEの比較検討

    兼藤努, 須田剛士, 吉川成一, 上村顕, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 野本実, 青柳豊, 和栗暢生

    日本消化器関連学会週間  2013.10 

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  • ぶどうゼリーを用いた超音波ガイド下穿刺手技の実習

    須田剛士

    医療シミュレーション学会  2013.7 

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  • 非アルコール性脂肪肝疾患における血清オステオポンチンの測定意義

    須田剛士, 兼藤努, 上村顕也, 野本実, 吉川成一, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 青柳豊

    日本肝臓学会総会  2013.6 

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  • 血清APM2濃度による肝細胞癌のシスプラチン感受性予測

    上村顕也, 須田剛士, 青柳豊

    日本肝臓学会総会  2013.6 

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  • HYDRODYNAMICS-BASED, LIVER-TARGETED NONVIRAL GENE THERAPY APPROACH FOR MONOGENIC DISEASES International conference

    TAKESHI SUDA, Takeshi Yokoo, Kenya Kamimura, Tsutomu Kanefuji, Masafumi Oda, Guisheng Zhang, Dexi Liu, Yutaka Aoyagi

    ヨーロッパ肝臓病学会  2013.4 

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  • 非アルコール性脂肪肝疾患における血清オステオポンチンの測定意義

    須田剛士, 兼藤努, 上村顕也, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 野本実, 青柳豊

    日本内科学会総会  2013.4 

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  • 超音波を用いた肝の病態評価－画像から機能へ－ Invited

    須田剛士

    日本消化器癌健診学会  2013.3 

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  • 傾向スコアを用いた高齢肝細胞癌症例に対する治療介入意義の検討

    須田剛士, 兼藤努, 青柳豊, 上村顕也, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 野本実

    日本消化器病学会総会  2013 

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  • Transarterial Oily Chemoembolizationの適応に対する考察

    兼藤努, 吉川成一, 上村顕也, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 須田剛士, 野本実, 青柳豊

    日本消化器病学会総会  2013 

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  • 肝細胞癌診断における高感度AFP-L3測定法の臨床的有用性

    田村康, 須田剛士, 青柳豊

    日本消化器病学会総会  2013 

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  • 輸血によるE型肝炎ウイルス(HEV)感染症例の一考察

    松山雄一, 古俣妙, 瀬下敏, 今田恒芳, 布施一郎, 布施香子, 森山雅人, 増子正義, 高橋祥史, 上村顕也, 須田剛士

    日本消化器病学会総会  2013 

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  • Nutritional intervention in cirrhotic patients with hepatocellular carcinoma on the basis of energy state assessment International conference

    Takeshi Suda, Tsutomu Kanefuji, Kazuki Yamada, Yuko S Komoro, Toshiko Murayama, Hideaki Nakayama, Kenya Kamimura, Yasushi Tamura, Masaaki Takamura, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa, Minoru Nomoto, Yutaka Aoyagi

    アジア太平洋肝臓学会  2012.11 

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  • 音響放射圧を用いて測定された肝内せん断弾性波速度の特徴とその有用性

    五十嵐正人, 上村顕也, 兼藤務, 田村康, 高村昌昭, 須田剛士, 川合弘一, 山際訓, 野本実, 青柳豊

    日本消化器関連学会週間  2012.10 

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  • APM2は肝細胞癌のシスプラチン効果予測指標となりうる

    上村顕也, 須田剛士, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 野本実, 青柳豊

    日本癌学会  2012.9 

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  • 肝細胞癌に対する肝動注療法における安全で効果的なシスプラチン量の設定

    須田剛士, 大崎暁彦, 上村顕也, 兼藤努, 土屋淳紀, 田村康, 高村昌昭, 五十嵐 正人, 川合弘一, 山際訓, 青柳豊

    日本癌学会  2012.9 

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  • 医薬工連携による新規遺伝子導入装置の開発と今後の展開

    上村顕也, 須田剛士, 横尾健, 兼藤努, Liu Dexi, 尾田雅文, 青柳豊

    日本DDS学会  2012.7 

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  • ESTABLISHING CLINICALLY APPLICABLE, IMAGE-GUIDED, AND COMPUTER-CONTROLLED HYDRODYNAMIC GENE DELIVERY FOR TREATMENT OF HEMOPHILIA B International conference

    Tsutomu Kanefuji, Kenya Kamimura, Takeshi Suda, Mingming Gao, Guishen Zhang, Yutaka Aoyagi, Dexi Liu

    日本遺伝子細胞治療学会  2012.6 

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  • 細胞外液性造影動態による認識が困難な超早期肝細胞性病変の近未来進展予測

    須田剛士, 上村顕也, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 青柳豊

    日本肝臓学会総会  2012.6 

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  • Long Term Transgene Expression in Rat Liver Using a Novel Electromotor-driven Hydrodynamic Gene Injector. International conference

    Takeshi Yokoo, Kenya Kamimura, Tsutomu Kanefuji, Takeshi Suda, Masafumi Oda, Guisheng Zhang, Dexi Liu, Yutaka Aoyagi

    全米遺伝子細胞治療学会  2012.5 

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  • Image-guided, Lobe-specific Hydrodynamic Gene Delivery to Baboon Liver International conference

    Kenya Kamimura, Takeshi Suda, Tsutomu Kanefuji, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu

    全米遺伝子細胞治療学会  2012.5 

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  • 肝細胞癌（HCC）に対するラジオ波焼灼療法（RFA）の効果と限界

    須田剛士, 上村顕也, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 青柳豊

    日本内科学会総会  2012.4 

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  • T1WIで高信号を示す結節におけるT1WIと肝細胞相のサブトラクション画像の有用性

    高野徹, 佐藤卓, 佐藤章子, 山崎元彦, 青山英史, 須田剛士, 加村毅, 山本哲史

    日本医学放射線学会  2012 

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  • ミニマル肝性脳症の診断とその特徴

    須田剛士, 小師優子, 青柳豊

    日本消化器病学会総会  2012 

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  • 肝疾患治療における非タンパク呼吸商(npRQ)測定の重要性

    兼藤努, 須田剛士, 青柳豊

    日本消化器病学会総会  2012 

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  • 当科で経験した肝硬変に深部出血を合併した3例

    渡邉順, 高村昌昭, 松尾祐冶, 野澤優次郎, 橋本哲, 佐藤祐一, 坂牧僚, 本田譲, 上村顕也, 土屋淳紀, 須田剛士, 青柳豊

    日本消化器病学会総会  2012 

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  • C型肝炎に対するインターフェロン治療によるAFP値変動と肝発癌抑制

    田村康, 上村顕也, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 須田剛士, 野本実, 青柳豊

    日本消化器病学会総会  2012 

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  • cryptogenic肝硬変とNASH肝硬変の臨床的比較検討

    川合弘一, 上村顕也, 田村康, 五十嵐正人, 須田剛士, 野本実, 青柳豊

    日本消化器病学会総会  2012 

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  • 高齢肝細胞癌症例に対する治療介入の是非

    須田剛士, 上村顕也, 田村康, 五十嵐正人, 川合弘一, 山際訓, 野本実, 青柳豊

    日本消化器病学会総会  2012 

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  • ハイドロダイナミック法によるヒヒ肝臓への遺伝子導入

    上村顕也, 須田剛士, 横尾健, 兼藤努, 田村康, 五十嵐正人, 川合弘一, Dexi Liu, 青柳豊

    日本消化器関連学会週間  2012 

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  • 新潟県と肝疾患診療連携拠点病院の協力による肝炎対策の新しい取り組み

    五十嵐正人, 須田剛士, 青柳豊

    日本消化器関連学会週間  2012 

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  • 消化器悪性腫瘍に対する分子標的治療-その現状と課題- Invited

    須田剛士

    日本医師会生涯教育講演会  2011.11 

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  • 入院後のエネルギー摂取量変化は肝細胞癌治療からの快復速度に影響する

    須田剛士, 山田一樹, 小師優子, 村山稔子, 青柳豊

    日本消化器関連学会週間  2011.10 

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  • Optimization of Image-Guided Hydrodynamic Gene Delivery to Liver of Large Animals International conference

    Kenya Kamimura, Takeshi Suda, Tsutomu Kanefuji, Guisheng Zhang, Dexi Liu

    全米遺伝子細胞治療学会  2011.5 

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  • Development of Electromotor-driven Injector for Hydrodynamic Gene Delivery International conference

    Takeshi Yokoo, Kenya Kamimura, Takeshi Suda, Masafumi Oda, Guisheng Zhang, Dexi Liu, Yutaka Aoyagi

    全米遺伝子細胞治療学会  2011.5 

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  • 非アルコール性脂肪肝炎における、肝内複数セグメントを対象とした経時的せん断弾性波速度測定の有用性

    須田剛士, 横尾健, 長崎啓祐, 原田浩一, 窪田智之, 菊池透, 上村朝輝, 青柳豊

    日本内科学会総会  2011.4 

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  • Acoustic Radiation Force Impulse-Imaging for non-invasive assessment of liver fibrosis: a pooled meta-analysis International conference

    Mireen Friedrich-Rust, Julia Nierfhoff, Monica Lupsor, Ioan Sporea, Carmen Fierbinteanu-Braticevici, Deike Strobel, Hirokazu Takahashi, Masato Yoneda, Takeshi Suda, Stefan Zeuzem, Eva Herrmann

    ヨーロッパ肝臓病学会  2011 

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  • Gd-EOB-DTPA造影MRIで乏血性かつ肝細胞造影相で低信号を示す病変の自然経過

    須田剛士, 高野徹, 土屋淳紀, 上村顕也, 矢野雅彦, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 青柳豊

    日本肝臓学会総会  2011 

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  • ハイドロダイナミック法を用いた遺伝子治療の前臨床研究

    上村顕也, 須田剛士, 青柳豊

    日本消化器病学会総会  2011 

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  • 肝細胞癌に対するミリプラチン使用経験とその治療効果についての検討

    田村康, 土屋淳紀, 上村顕也, 矢野雅彦, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 須田剛士, 大越章吾, 野本実, 青柳豊

    日本消化器病学会総会  2011 

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  • 肝細胞癌患者におけるシスタチンCのGFRマーカーとしての有用性

    川合弘一, 星山良樹, 伊藤正行, 山田一樹, 須田剛士, 棚橋洋子, 松野容子, 松戸隆之, 青柳豊, 岡田正彦

    日本消化器病学会総会  2011 

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  • 肝炎治療費助成制度が全国および新潟県のC型肝炎治療均てん化に与えた影響とその課題

    五十嵐正人, 須田剛士, 青柳豊

    日本消化器関連学会週間  2011 

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  • 切除不能進行肝細胞癌に対するミリプラ®/アイエーコール®併用肝動注療法（第I相試験）

    上村顕也, 須田剛士, 土屋淳紀, 矢野雅彦, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 大越章吾, 野本実, 青柳豊

    日本肝臓学会総会  2011 

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  • APM2 is a Candidate of Predictive Marker for Cisplatin Sensitivity in Hepatocellular Carcinoma International conference

    Kenya Kamimura, Takeshi Suda, Yasuo Fukuhara, Akihiko Osaki, Masato Igarasi, Yutaka Aoyagi

    米国癌研究会議  2011 

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  • 3次元モデリングを考慮した超音波エコー画像の方位分解能向上手法の検討

    武田知己, 尾田雅文, 原利昭, 須田剛士, 上村顕也

    日本機械学会  2011 

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  • 肝細胞癌に対する侵襲的治療時の栄養介入における呼気ガス分析の有用性

    須田剛士, 山田一樹, 青柳豊

    日本消化器病学会総会  2011 

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  • 高感度AFP－L3分画と肝細胞癌切除組織所見および予後との関連性についての検討

    田村康, 五十嵐正人, 川合弘一, 須田剛士, 青柳豊, 黒崎功, 白井良夫, 畠山勝義

    日本肝臓学会総会  2011 

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  • 肝細胞がんで発現異常を示すMusashi2遺伝子の機能解析

    中村勘彦, 高橋昌幸, 小谷昌司, 梨本正之, 三嶋行雄, 須田剛士, 青柳豊, 高橋由明

    日本分子生物学会  2011 

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  • NASHにおけるせん断弾性波速度の経時的な変化とその測定意義

    須田剛士, 窪田智之, 原田浩一, 上村朝輝, 青柳豊

    日本消化器関連学会週間  2010.10 

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  • DEVELOPMENT OF ELECTROMOTOR-DRIVEN SYSTEM FOR HYDRODYNAMIC GENE DELIVERY International conference

    Takeshi Suda, Tsuyoshi Imai, Kenya Kamimura, Masafumi Oda, Tsutomu Kanefuji, Guishenfg Zhang, Dexi Liu, Takeshi Yokoo, Yasushi Tamura, Masato Igarashi, Hirokazu Kawai, Yutaka Aoyagi

    日本遺伝子細胞治療学会  2010.7 

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  • 部分的脾動脈塞栓術後の血小板数予測の試み

    大崎暁彦, 須田剛士, 青柳豊

    日本消化器関連学会週間  2010 

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  • ハイドロダイナミック遺伝子導入法による遺伝子治療の実現に向けて

    上村顕也, 須田剛士, Dexi Liu, 田村康, 五十嵐正人, 川合弘一, 青柳豊

    日本消化器関連学会週間  2010 

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  • 肝細胞癌サーベイランスにおける低濃度域AFPの臨床的意義

    田村康, 五十嵐正人, 川合弘一, 須田剛士, 青柳豊

    日本肝臓学会総会  2010 

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  • エネルギー代謝変化と肝細胞癌に対する治療侵襲からの回復、在院日数との関係

    山田一樹, 須田剛士, 大崎暁彦, 上村博輝, 土屋淳紀, 矢野雅彦, 田村康, 高村昌昭, 五十嵐正人, 川合弘一, 山際訓, 松田康伸, 大越章吾, 野本実, 青柳豊

    日本肝臓学会総会  2010 

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  • Image-guided, Computer-controlled Hydrodynamic Gene Delivery to Liver Results in Therapeutic Level of Human Alpha-1 Antitrypsin in Pigs and Dogs International conference

    Kenya Kamimura, Takeshi Suda, Guisheng Zhang, Dexi Liu

    全米遺伝子細胞治療学会  2010 

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  • 肝細胞癌で特異的に発現変動する非コードRNA

    須田剛士, 日野公洋, 青柳豊

    日本消化器病学会総会  2010 

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  • 肝臓を対象とした非ウイルスベクターの開発-マウスからヒトへの応用を目指して-

    須田剛士, 上村顕也, Dexi Liu, 田村康, 五十嵐正人, 川合弘一, 青柳豊

    日本消化器病学会総会  2010 

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  • THE PROGNOSTIC SIGNIFICANCE OF A HEPATIC ARTERIAL INFUSION CHEMOTHERAPY USING FINE CDDP POWDER IN PATIENTS WITH HEPATOCELLULAR CARCINOMA International conference

    TAKESHI SUDA, Hirokazu KAWAI, Akihiko OHSAKI, Atsunori TSUCHIYA, Masahiko YANO, Yasushi TAMURA, Masaaki TAKAMURA, Masato IGARASHI, Satoshi YAMAGIWA, Yutaka AOYAGI

    国際京都肝癌シンポジウム  2009.6 

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  • Hydrodynamic Gene Delivery to Swine Skeletal Muscle Using Image-Guided, Computer-Controlled Injection System International conference

    Kenya Kamimura, Takeshi Suda, Guisheng Zhang, Dexi Liu

    全米遺伝子細胞治療学会  2009 

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  • 慢性肝疾患症例における入院にともなうエネルギー代謝変化とNSTの重要性

    山田一樹, 須田剛士, 大崎暁彦, 上村博輝, 土屋淳紀, 窪田智之, 高村昌昭, 田村康, 矢野雅彦, 五十嵐正人, 山際訓, 大越章吾, 野本実, 青柳豊, 中山秀章, 川合弘一, 村山稔子, 桜井優子

    日本消化器関連学会週間  2009 

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  • 肝細胞癌診断, 予後予測における高感度AFP-L3測定法の臨床的有用性

    田村康, 須田剛士, 青柳豊

    日本消化器関連学会週間  2009 

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  • ラジオ波焼灼術における硬膜外麻酔の鎮痛効果の検討

    五十嵐聡, 川合弘一, 窪田智之, 土屋淳紀, 矢野雅彦, 田村康, 高村昌昭, 五十嵐正人, 山際訓, 須田剛士, 松田康伸, 大越章吾, 岡本学, 野本実, 青柳豊

    日本消化器関連学会週間  2009 

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  • 音響放射圧刺激に基づく肝硬度測定の臨床的意義

    窪田智之, 須田剛士, 青柳豊

    日本消化器関連学会週間  2009 

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  • 非アルコール性脂肪性肝炎を背景に多中心性発生したと思われる肝細胞癌の3例

    川合弘一, 野本実, 窪田智之, 田村康, 高村昌昭, 五十嵐正人, 山際訓, 須田剛士, 松田康伸, 大越章吾, 岡田正彦, 青柳豊

    日本消化器関連学会週間  2008 

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  • Image-Guided Hydrodynamic Gene Delivery to Pig Liver International conference

    Kenya Kamimura, Takeshi Suda, Wei Xu, Guisheng Zhang, Dexi Liu

    全米遺伝子細胞治療学会  2008 

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  • A case of Budd-Chiari syndrome (BCS) with severe esophageal varices caused by myeloproliferative disease (MPD) International conference

    Tomohiro Iwasaki, Hirokazu Kawai, Takeshi Suda, Kenji Suzuki, Yoshinobu Sato, Ken Toba, Toru Takahashi, Minoru Nomoto, Yutaka Aoyagi

    アジア太平洋肝臓学会  2008 

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  • Computer-Controlled Hydrodynamic Gene Delivery System International conference

    Takeshi Suda, Dexi Liu

    全米遺伝子細胞治療学会  2007 

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  • 末梢血中肝細胞癌由来hTERTの前向き定量測定とその生物学的悪性度指標としての臨床的意義

    田村康, 和栗暢夫, 須田剛士, 福原康夫, 小林真, 五十嵐正人, 川合弘一, 野本実, 青柳豊

    日本消化器病学会総会  2007 

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  • Effective Volume for Hydrodynamic Gene Delivery in the Liver International conference

    Takeshi Suda, Dexi Liu

    全米遺伝子細胞治療学会  2006 

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  • 肝細胞癌患者の予後予測におけるテロメラーゼ発現を指標とした末梢血中癌細胞検出の有用性についての検討

    田村康, 和栗暢生, 須田剛士, 野本実, 川合弘一, 五十嵐正人, 小林真, 福原康夫, 青柳豊

    日本肝臓学会総会  2006 

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  • HBV蛋白が宿主メッセージ発現に与える影響－siRNAによるHBV mRNAノックダウン肝癌細胞株のcDNAマイクロアレイ解析－

    福原康夫, 須田剛士, 田村康, 小林真, 五十嵐正人, 川合弘一, 大越章吾, 青柳豊

    日本肝臓学会総会  2006 

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  • 肝臓CTから肝硬変推定のための一手法

    石川雅浩, 内田日高, 玉木徹, 山本正信, 五十嵐正人, 須田剛士, 青柳豊

    電子情報通信学会  2005.3 

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  • 腫瘍マーカーによる肝細胞癌（HCC）の予後階層化，Biological stagingの試み

    五十嵐正人, 青柳豊, 見田有作, 川合弘一, 小林真, 福原康夫, 須田剛士, 渡辺雅史, 大越章吾, 野本実

    日本肝臓学会総会  2005 

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  • Essential Parameters for Efficient Hydrodynamic Gene Delivery International conference

    Takeshi Suda, Regis Vollmer, Dexi Liu

    全米遺伝子細胞治療学会  2005 

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  • C型慢性肝疾患に対するインターフェロン治療の肝線維化抑制とその発癌阻止効果

    大越章吾, 上村朝輝, 青柳豊, 須田剛士, 五十嵐正人

    日本消化器病学会総会  2005 

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  • 肝細胞癌(HCC)の予後階層化の因子としてのアルファフェトプロテイン(AFP)L3分画ならびにPIVKA-IIの臨床的意義

    見田有作, 五十嵐正人, 川合弘一, 小林真, 福原康夫, 須田剛士, 渡辺雅史, 大越章吾, 野本実, 青柳豊

    日本消化器病学会総会  2005 

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  • 肝細胞癌の肝内局在から見た治療成績の検討

    五十嵐正人, 須田剛士, 川合弘一, 見田有作, 小林真, 福原康夫, 野本実, 青柳豊, 若井俊文, 白井良夫

    日本消化器関連学会週間  2005 

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  • Recommendation for the management of the patients with hepatocellular carcinoma based on historical data of Niigata Liver Disease Study Group. International conference

    T. Suda, M. Igarashi, Y. Aoyagi, Niigata Liver, Disease Study Group

    日ロ医学医療交流国際シンポジウム  2004 

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  • 肝細胞がんの発生と進展に関係する遺伝子の解析

    畔上周子, 福原康夫, 須田剛士, 青柳豊, 小谷昌司, 高木奈津子, 福本学, 三嶋行雄, 木南凌, 高橋由明

    日本分子生物学会  2004 

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  • 肝細胞癌（HCC）におけるアルファフェトプロテイン（AFP）L3分画の生物学的悪性度評価ならびに予後予測因子としての臨床的意義

    見田有作, 須田剛士, 川合弘一, 和栗暢夫, 五十嵐正人, 小林真, 福原康夫, 渡辺雅史, 野本実, 青柳豊

    日本肝臓学会総会  2004 

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  • 肝細胞癌(HCC)予後判定因子としてのアルファフェトプロテイン(AFP)L3分画の意義, 特にAFP低濃度域での検討

    見田有作, 須田剛士, 五十嵐正人, 和栗暢生, 川合弘一, 小林真, 福原康夫, 青柳豊, 里村慎二, 荒井由美

    日本消化器病学会総会  2004 

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  • CTAP/CTHAの適応と限界

    川合弘一, 須田剛士, 青柳豊, 福原康夫, 小林真, 五十嵐正人, 和栗暢生, 見田有作

    日本消化器関連学会週間  2004 

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  • 肝細胞癌に対する生体肝移植：適応拡大に向けた治療戦略

    竹石利之, 佐藤好信, 中塚英樹, 小林隆, 大矢洋, 市田隆文, 須田剛士, 青柳豊, 畠山勝義

    日本肝臓学会総会  2004 

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  • 新潟肝疾患研究会所属多施設調査に基づいた肝細胞癌診療指針

    五十嵐正人, 須田剛士, 青柳豊

    日本肝臓学会総会  2004 

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  • わが国の肝細胞癌の診療におけるJIS scoreの優位性

    五十嵐正人, 須田剛士, 青柳豊

    日本消化器病学会総会  2004 

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  • 新潟県のデータから検討した肝細胞癌の診療指針

    福原康夫, 須田剛士, 五十嵐正人, 見田有作, 高村昌昭, 野本実, 渡辺雅史, 市田隆文, 青柳豊

    日本消化器病学会総会  2004 

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  • 肝細胞癌の治療戦略:初回治療としての穿刺治療と肝切除との治療成績の比較

    若井俊文, 白井良夫, 横山直行, 畠山勝義, 須田剛士, 五十嵐正人, 青柳豊

    日本消化器病学会総会  2004 

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  • 肝細胞癌の診断および予後推定におけるPIVKA-IIの臨床的意義, 特にAFPとの比較において

    見田有作, 須田剛士, 川合弘一, 和栗暢夫, 黒岩敬, 五十嵐正人, 小林真, 福原康夫, 青柳豊

    日本消化器関連学会週間  2003 

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  • 肝細胞癌に対するラジオ波熱凝固療法の検討

    高村昌昭, 須田剛士, 五十嵐正人, 福原康夫, 渡辺雅史, 青柳豊

    日本消化器病学会総会  2003 

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  • 肝細胞癌におけるPIVKA-II測定の臨床的意義, 特に高感度法の有用性と予後因子について

    見田有作, 須田剛士, 川合弘一, 和栗暢夫, 黒岩敬, 五十嵐正人, 小林真, 福原康夫, 青柳豊

    日本消化器病学会総会  2003 

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  • 末梢流血中に肝癌細胞が存在することの転移巣形成における意義

    和栗暢生, 須田剛士, 川合弘一, 見田有作, 黒岩敬, 五十嵐正人, 小林真, 福原康夫, 青柳豊, 佐藤好信, 黒崎功, 白井良夫

    日本肝臓学会総会  2003 

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  • 癌化に伴うhuman telomerase RNA (hTR)の発現制御

    須田剛士, 青柳豊

    日本癌学会  2002 

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  • 肝細胞癌(HCC)の生物学的悪性度の指標としてのフコシル化アルファフェトプロテイン(AFP)ならびにa1-6フコース転移酵素(aFT)の臨床的意義

    見田有作, 青柳豊, 須田剛士

    日本消化器病学会総会  2002 

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  • 慢性肝疾患、肝細胞癌組織におけるテロメア長の不均一化

    須田剛士, 横田隆司, 福原康夫, 小林真, 五十嵐正人, 黒岩敬, 和栗暢生, 川合弘一, 見田有作, 青柳豊

    日本肝臓学会総会  2002 

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  • Immunomagnetic beadsを用いた細胞分画後のhTERT mRNA検出による, 末梢血中肝癌細胞存在診断の試み

    和栗暢生, 須田剛士, 菅原聡, 青柳豊, 川合弘一, 見田有作, 黒岩敬, 五十嵐正人, 小林真, 福原康夫, 野本実, 朝倉均, 黒崎功, 畠山勝義

    日本消化器関連学会週間  2001 

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  • 肝細胞癌におけるα1-6 fucosyltransferaseのmRNA発現について

    黒岩敬, 青柳豊, 須田剛士, 見田有作, 福原康夫, 小林真, 五十嵐正人, 和栗暢生, 川合弘一, 朝倉均

    日本消化器関連学会週間  2001 

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  • テロメア反復配列数とテロメラーゼ活性測定による肝細胞癌のリスク管理

    須田剛士, 青柳豊, 朝倉均

    日本消化器関連学会週間  2001 

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  • INTER-CHROMOSOMAL TELOMERE LENGTH VARIATION AND TELOMERE MAINTENANCE International conference

    T. Suda, T. Yokota, A. Fujiyama, M. Takimoto, Y. Aoyagi, H. Asakura

    ヨーロッパ肝臓病学会  2000 

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  • 肝細胞癌の存在診断, 発癌リスクならびに生物学的悪性度の評価におけるテロメア関連マーカーの有用性

    須田剛士, 青柳豊

    日本消化器病学会総会  2000 

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  • 肝細胞癌におけるα1-6 fucosyltransferase mRNAの発現と酵素活性との関係

    黒岩敬, 青柳豊, 見田有作, 須田剛士, 小林真, 五十嵐正人, 和栗暢生, 川合弘一, 五十嵐広隆, 朝倉均

    日本消化器病学会総会  2000 

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  • 肝細胞癌発癌過程でのテロメア維持機構の動態

    須田剛士, 藤山秋佐夫, 青柳豊

    日本肝臓学会総会  2000 

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  • 発癌過程におけるテロメア長、テロメラーゼ活性、ならびにテロメア結合蛋白の動態解析

    須田剛士, 横田隆司, 藤山秋佐夫, 五十川修, 瀧本光弘, 木南凌, 斉藤義之, 白井, 畠山勝義, 清水武昭, 阿部要一, 小出則彦, 青柳豊, 朝倉均

    日本肝臓学会総会  1999 

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  • 肝細胞癌(HCC)におけるアルファフェトプロテイン(AFP)フコシル化機構の酵素学的背景に関する研究

    見田有作, 青柳豊, 黒岩敬, 和栗暢生, 川合弘一, 横田隆司, 五十嵐広隆, 五十嵐正人, 須田剛士, 朝倉均

    日本消化器病学会総会  1999 

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  • 膵癌診断を目的とした膵液中テロメラーゼ構成蛋白発現の検討

    関慶一, 夏井正明, 須田剛士, 山崎国男, 関根輝夫, 鈴木康史, 林俊一, 成沢林太郎, 青柳豊, 朝倉均

    日本消化器病学会総会  1999 

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  • 肝細胞癌発癌過程におけるテロメア長の変化とEST2/hTRT, TRF1発現との関係に関する検討

    横田隆司, 柳雅彦, 須田剛士, 野本実, 清水武昭, 阿部要一, 小出則彦, 青柳豊, 朝倉均

    日本消化器病学会総会  1999 

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  • 癌細胞におけるテロメア維持機構と、その関与因子測定の臨床的な意義

    須田 剛士, 朝倉 均

    日本消化器関連学会週間  1999 

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  • テロメア反復配列数ならびにテロメラーゼ活性測定の臨床的な意義

    須田剛士, 藤山秋佐夫, 朝倉均

    日本消化器病学会総会  1999 

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  • 慢性肝疾患、肝細胞癌におけるテロメア長、テロメラーゼ活性測定の意義

    須田剛士, 朝倉均

    日本消化器関連学会週間  1998 

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  • 消化器癌におけるN-アセチルグルコサミン転移酵素V型(GnT-V)の活性, ならびに発現とその臨床的意義

    柳雅彦, 青柳豊, 須田剛士, 五十嵐正人, 黒岩敬, 和栗暢生, 見田有作, 川合弘一, 横田隆司, 五十嵐広隆, 鈴木康史, 朝倉均

    日本消化器病学会総会  1998 

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  • Quantitation of telomerase activity in hepatocellular carcinoma International conference

    Takeshi Suda, Osamu Isokawa, Yutaka Aoyagi, Minoru Nomoto, Kazuhiro Tsukada, Takeaki Shimizu, Yasufumi Suzuki, Akira Naito, Hirotaka Igarashi, Masahiko Yanagi, Toru Takahashi, Hitoshi Asakura

    Internet Association for Biomedical Sciences  1997 

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    Language：English   Presentation type：Oral presentation (general)  

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Industrial property rights

  • 時間‐脈管内圧制御に基づく細胞内薬物送達システム及び細胞内薬物送達方法

    須田剛士, 上村顕也, 尾田雅文

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    Applicant：国立大学法人 新潟大学

    Application no：特願2010-136490  Date applied：2010.6

    Patent/Registration no：特許第5922864  Date issued：2016.4

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Awards

  • New Investigator of the Month

    2014   American Society of Gene and Cell Therapy  

    Takeshi Suda

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    Award type：Award from international society, conference, symposium, etc.  Country：United States

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  • Travel Grant Award

    2007   American Society of Gene and Cell Therapy  

    Takeshi Suda

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    Award type：Award from international society, conference, symposium, etc.  Country：United States

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  • Excellence in Research Award

    2007   American Society of Gene and Cell Therapy  

    Takeshi Suda

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    Award type：Award from international society, conference, symposium, etc.  Country：United States

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  • 学術奨励賞

    2003   新潟県医師会  

    須田剛士

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

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  • 市田賞（基礎医学分野）

    2001   市田基金委員会  

    須田剛士

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    Country：Japan

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  • 浜名湖シンポジウム優秀賞

    1999   国際科学振興財団フォーラム  

    須田剛士

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

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Research Projects

  • 肝硬度（SHEAR WAVE ELASTOGRAPHY: SWE®）の整合性検定

    2016.12 - 2017.3

    System name：受託研究

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    Grant type：Competitive

    肝硬度は、慢性肝疾患の進展に伴い肝内に蓄積する線維を非侵襲的に定量する方法で、肝病態を客観的に評価する方法としの有用性が報告されています。当院では、TOSHIBA社製Aplio 500超音波診断装置に装備されているShear Wave Elastogrphy（SWE）を用いた肝硬度測定を実施し、これまでに得られたデータの解析結果から独自の診断基準を設けたレポーティングシステムを運用しています。
    TOSHIBA社は、SWEの測定精度改善を目的としたバージョンアップを2016年1月に発表しました。当院では2016年3月にバージョン2となりましたが、バージョンアップ前後の測定値に整合性が担保されていることを示す臨床データが存在しないため、現在、当院の診断基準でSWEを運用することの理論的な根拠が失われています。
    本研究は、同一症例に対してSWEのバージョン1とバージョン2の測定を同日に実施し、両バージョンの整合性に関する解析を行い、その結果を当院のレポーティングシステムに反映させることを目

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  • 母集団バイアスを排除した非アルコール性脂肪肝炎（NASH）の実態調査と、それに基づくNASH高危険群設定の試み

    2014.10 - 2017.3

    System name：補助金

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    Grant type：Competitive

    近年、メタボリック症候群の蔓延が社会問題となっており、その主たる表現型である非アルコール性脂肪肝疾患（NAFLD）への介入の必要性が叫ばれているが、人口の30%にも達するとされるNAFLD症例全例に介入するのは困難であり、NAFLDの中でも進行性のNASHを介入対象とするのが現実的である。しかし、肝生検による診断が基本のNASHを簡便に抽出する方法が存在しないため、NASHの実態把握と囲い込みを達成できていないのが現状である。
    本研究は、肝硬度測定という肝生検を代価する非侵襲的検査を世界に先駆けて健診に組み入れることで、母集団バイアスの極めて低い多数例からなるNAFLDコホートを対象とした定量的な肝病態と生活実態の評価を実施し、我が国におけるNAFLD、NASHの実態を明らかにするとともに、NASH囲い込みのための簡便なスコアリング法の確立を目的とする。

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  • Hydrodynamic Gene Delivery to Non-human Primates

    Grant number：26860354

    2014.4 - 2018.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    KAMIMURA KENYA, Terai Shuji, Aoyagi Yutaka, Suda Takeshi, Yokoo Takeshi, Fujisawa Nobuyoshi, Yoshida Hidenori, Oda Masafumi, Liu Dexi

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    Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

    gene therapy. We have previously reported the effectiveness of image-guided liver-lobe specific hydrodynamic gene delivery. Here, we have assessed the efficiency and the safety of the procedure in non-human primates in this study. The injection catheter was inserted in the lobular hepatic veins and the hydrodynamic injection of the marker plasmid DNA was performed with a various parameters including, injection pressure, volume, flow rate, etc. Based on the results obtained, the optimum parameters were defined followed by the long-term gene expression study using the parameters injecting plasmid expressing human factor IX DNA. The efficiency and safety of the procedure have been confirmed and the development of the gene delivery system and the pre-clinical study are ongoing research programs.

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  • NASHの病態におけるNrf2とミトコンドリア異常の関与メカニズムの解明

    2013.4 - 2016.3

    System name：科学研究費補助金

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    Grant type：Competitive

    脂肪肝モデルマウスでは肝ミトコンドリアDNA（mtDNA）のコピー数は増加傾向だったが、ダイエット食により正常レベルにまで戻った。一方、非アルコール性脂肪肝炎（NASH）モデルマウスではmtDNAコピー数は減少した。これらのモデルにおけるmtDNAコピー数は、ミトコンドリアの生合成・分解に関連する遺伝子発現量の変化により制御されていると考えられた。NASHではミトコンドリア数の変化を伴った酸化ストレスを介して肝病変が進展していることが明らかとなった。

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  • ハイドロダイナミック力を用いた肝ミトコンドリアへの遺伝子導入システムの開発

    2012.4 - 2015.3

    System name：科学研究費補助金

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    Grant type：Competitive

    ミトコンドリア（Mit）特異的な遺伝子治療の実現に向け、Mit特異的なプロモーターと終止配列、ならびにMit特異的なコドン使用に特化した遺伝子からなるプラスミドと、その送達システムの開発を行った。
    単純なハイドロダイナミック導入法（HD）では明らかなMitでの遺伝子発現が確認できなかったため、Mit移行シグナルとそれに結合するタンパクの併用を試みた。移行シグナルと結合タンパクをクローニングした後、HDの物理的なインパクトによる結合の解離を防止するため、溶液の粘弾性を利用し注入溶液量と速度をともに半減させたHDシステムを新規に開発した。現在、これらを用いてMit特異的な遺伝子導入を検証中。

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  • 非アルコール性脂肪肝疾患の現状把握と栄養・運動療法介入の評価

    2011.4 - 2014.3

    System name：その他の研究制度

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    Grant type：Competitive

    メタボリックシンドローム関連疾患で医療機関を受診していない一般市民（健康診断受診者）に占める非アルコール性脂肪肝疾患（NAFLD: non-alcoholic fatty liver diseases）罹患者数の把握と、非薬物療法（栄養指導、運動療法）による介入の意義を明らかとする。

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  • ハイドロダイナミック遺伝子治療装置の制御パラメータ導出手法の開発

    2011.4 - 2013.3

    System name：科学研究費補助金

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    Grant type：Competitive

    本研究は、物理的非ウイルスベクターによる遺伝子治療の臨床応用を目指し、大型動物における効率的かつ再現性の高い局所的ハイドロダイナミック遺伝子導入のための新規導入システムの安全性確立を目的とした。導入実験後のラット肝臓の形状を3D CADによるモデリング作業を経て、内部の血管も含むラット肝臓CADモデルを作成した。FEモデルを作成し、有限要素応力解析システムを用いて解析した。その結果、FEモデルの形状変化が、実験時の実際のラット肝臓の変形と定性的かつ定量的に一致したことから、肝臓内の応力状態の推定結果に基づき、適切な薬液導入圧力を与えられる制御パラメーターの決定が可能となることが示唆された。

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  • フット8コンディショナルノックアウトマウスを用いた肝癌悪性化責任分子の同定

    2011.4 - 2012.3

    System name：科学研究費補助金

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    Grant type：Competitive

    α1-6フコース転移酵素(FUT8)は、肝癌の生物学的悪性度の指標とされるフコシル化AFP産生に関与しているが、その分子機構は解明されていない。我々は肝細胞特異的に遺伝子発現抑制を行い、発癌過程におけるFUT8蛋白機能を解析する手法として、コンディショナルノックアウトマウス(FUT8loxP/loxP‐AlbCre+/-マウス)を作製した。このマウス肝臓において、Cre酵素切断特異的DNAフラグメントを確認し、FUT8mRNA遺伝子発現の低下を確認した。しかし、HPLCを用いた肝FUT8活性を測定では明らかな活性低下は確認できず、レクチンマイクロアレイを用いた肝糖蛋白糖鎖プロファイリングではα1-6フコースは対象マウスのそれに比較し有意なシグナル強度の変化は確認できなかった。

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  • 肝硬度ならびに頚動脈硬化度測定によるメタボリック症候群の定量的な病態評価と、同疾患に対する医療介入効果の判定

    2010.11 - 2011.3

    System name：その他の研究制度

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    Grant type：Competitive

    本プロジェクトは、近年、社会問題となっているメタボリック症候群に関して、主たる表現型であるにもかかわらず非侵襲的な診断と治療効果の判定方法が確立されていない非アルコール性脂肪肝炎と動脈硬化に着目し、当院が有する最新の資産を活用するとともに当院の複数部門が有機的に連携することで、疫学的なデータの収集と治療介入効果の評価を実施し、最先端の医療を社会に還元することで社会福祉に貢献することを目的としています。

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  • 入院に伴う摂取カロリー変化が慢性肝疾患の エネルギー代謝変化に及ぼす影響の解析

    2009.8 - 2015.3

    System name：その他の研究制度

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    Grant type：Competitive

    以下の各項目の確認と解析を本研究の目的とする。
    1) 入院に伴う摂取カロリーの低下が、非蛋白性呼吸商の低下を招来すること
    2) 家庭での摂取カロリーを維持することが、非蛋白性呼吸商の低下を防止すること
    3) 安静時エネルギー消費量対比の摂取カロリーが均一な集団における、分枝鎖アミノ酸製剤就寝前投与の非蛋白性呼吸商に対する効果
    4) 非蛋白性呼吸商、すなわちエネルギー代謝状態と潜在性脳症との関係
    5) 分枝鎖アミノ酸製剤就寝前投与の潜在性脳症に対する効果
    6) 肝細胞癌に対する治療後の回復速度と非蛋白性呼吸商との関係

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  • 糖鎖表出を指標とした肝癌治療戦略

    2008.4 - 2011.3

    System name：科学研究費補助金

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    Grant type：Competitive

    α1-6フコース転移酵素(FUT8)は、肝癌の生物学的悪性度の指標とされるフコシル化AFP産生に関与しているが、その分子機構は解明されていない。肝癌細胞のFUT8遺伝子発現を抑制し、細胞増殖や細胞浸潤能および糖鎖構造の変化に対する基礎的検討を行なった。SiRNAの手法では、FUT8遺伝子発現抑制を認めたが、細胞増殖や浸潤能の有意な変化は確認できず、糖鎖プロファイリング解析では、細胞内のフコシル化蛋白質の低下を確認できなかった。肝細胞特異的に完全な遺伝子発現抑制を行い、発癌発癌過程におけるFUT8蛋白機能を解析する手法として、新たにFUT8コンディショナルノックアウトマウスを作製した。現在、同マウスの肝組織でのFUT8のメッセージが低下している結果を得,蛋白機能を解析中で、引き続き同マウスの肝発癌実験を準備中である。

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  • 糖鎖を標的とした肝癌遺伝子治療戦略

    2004.4 - 2006.3

    System name：科学研究費補助金

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    Grant type：Competitive

    本研究では,AFPをはじめとするフコシル化糖蛋白とその酵素学的背景であるFut8発現を指標として,肝癌組織中の糖鎖転移酵素遺伝子高発現および低発現遺伝子をスクリーニングし,それらの遺伝子ならびにその糖蛋白の同定を試みた.まず,Fut8活性抑制による糖鎖構造変化と,それに伴う肝癌細胞の浸潤動態の変化を細胞系列の樹立によって評価した.Fut8アンチセンスRNAによる発現抑制実験を行い,アンチセンスRNAをHepG2細胞にリポフェクションした系のフコシル化分画は抑制されている事を確認した.次に,Fut8に対するsiRNAの持続発現により,AFPのフコシル化が安定して抑制されるsiRNA持続発現株の樹立を試みた.Fut8 mRNAの1002塩基のAA配列に続く19塩基配列からなる配列を,polymerase-III H1-RNA gene promotorの制御下に,ポリA配列を欠き3'端にUU突出を有するRNAが転写されるベクターであるpSUPER.retro(OligoEngine, USA)にクローニングした.また,配列特異的発現抑制を確認するため,19配列の第9塩基をGからAに置換した変異配

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  • 各染色体ごとのテロメア反復数の動態把握－細胞の老化、不死化、癌化のメカニズム解明に向けて－

    1997.4 - 1998.3

    System name：塚田医学奨学金

    Awarding organization：民間財団等

    須田剛士

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    Authorship：Principal investigator  Grant type：Competitive

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