Updated on 2022/12/01

写真a

 
SUZUKI Yuji
 
Organization
Brain Research Institute Center for Integrated Human Brain Science Associate Professor
Title
Associate Professor
External link

Degree

  • 新潟大学大学院医学研究科 ( 2003.9   新潟大学 )

Research Interests

  • 核磁気共鳴学

  • 発達神経学

  • MRI/PET/SPECT

  • Neuroimaging

  • Pediatric neurology

Research Areas

  • Life Science / Function of nervous system

  • Life Science / Neuroscience-general

  • Life Science / Embryonic medicine and pediatrics

Research History (researchmap)

  • Niigata University   Brain Research Institute Center for Integrated Human Brain Science Department of Functional Neurology and Neurosurgery   Associate Professor

    2014.7

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  • Niigata University   Brain Research Institute Center for Bioresources   Associate Professor

    2008.3 - 2014.6

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  • Niigata University

    1997.10 - 1998.3

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    Country:Japan

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  • 北海道大学医学部附属病院   小児科   医員

    1996.4 - 1997.9

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    Country:Japan

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Research History

  • Niigata University   Brain Research Institute Center for Integrated Human Brain Science Department of Functional Neurology and Neurosurgery   Associate Professor

    2014.7

  • Niigata University   Brain Research Institute Center for Bioresources   Associate Professor

    2008.3 - 2014.6

Education

  • Niigata University   Graduate School, Division of Medicine

    1998.4 - 2003.9

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    Country: Japan

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  • 北海道大学   医学部

    - 1991.3

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    Country: Japan

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Professional Memberships

 

Papers

  • 無鎮静小児MRI撮像のための統合的プレパレーション 被験者中心のプロトコール構築と実践

    山田 謙一, 鈴木 清隆, 鈴木 雄治, 渡辺 将樹

    脳と発達   53 ( 3 )   223 - 223   2021.5

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    Language:Japanese   Publisher:(一社)日本小児神経学会  

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  • Retinal Aquaporin-4 and Regulation of Water Inflow Into the Vitreous Body. International journal

    Satoshi Ueki, Yuji Suzuki, Hironaka Igarashi

    Investigative ophthalmology & visual science   62 ( 2 )   24 - 24   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    Purpose: Details of the posterior eye water dynamics are unclear. Aquaporin-4 (AQP4), a water channel, plays an important role in water dynamics in the central nervous system and is also present in the ocular tissue. The purpose of this study was to reveal the role of AQP4 in the water dynamics of the posterior eye using in vivo JJ vicinal coupling proton exchange (JJVCPE) magnetic resonance imaging (MRI) of AQP4 knockout (KO) mice and their wild-type littermates (controls). Methods: JJVCPE MRI of the eye was performed on five AQP4 KO mice and seven control mice. We assessed the normalized signal intensities of a region of interest (ROI) set in the vitreous body after H217O administration. The results of the two groups were compared using a two-tailed Mann-Whitney U test. Results: A statistical analysis revealed that the normalized ROI signal intensities at the steady state were significantly lower (P = 0.010, <0.05) in the AQP4 KO mice (mean ± SD, 84.5% ± 2.7%) than the controls (mean ± SD, 88.8% ± 1.9%). Conclusions: The present study using JJVCPE MRI of the eye demonstrated that retinal AQP4 has a potential role in the regulation of water inflow into the vitreous body. Absence of AQP4 in the KO mice probably induces lower water outflow from the vitreous body. Our results could help clarify the pathogenesis of various ocular diseases.

    DOI: 10.1167/iovs.62.2.24

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  • Participant-driven Simulation Protocol With a Mock Scanner for Pediatric Magnetic Resonance Neuroimaging Preparation Without Sedation Reviewed

    Kenichi Yamada, Yuji Suzuki, Satoshi Ueki, Kosuke Itoh, Masaki Watanabe, Kiyotaka Suzuki, Hironaka Igarashi

    Clinical Simulation in Nursing   47   40 - 47   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.ecns.2020.07.002

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  • Cerebellar Volumes Associate with Behavioral Phenotypes in Prader-Willi Syndrome Reviewed

    Kenichi Yamada, Masaki Watanabe, Kiyotaka Suzuki, Yuji Suzuki

    The Cerebellum   2020.7

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s12311-020-01163-1

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    Other Link: http://link.springer.com/article/10.1007/s12311-020-01163-1/fulltext.html

  • Skull diploë is rich in aquaporin-4 Reviewed International journal

    Yuji Suzuki, Hiroki Kitaura, Yukimi Nakamura, Akiyoshi Kakita, Vincent J. Huber, Nicholas Capozzoli, Ingrid L. Kwee, Tsutomu Nakada

    Heliyon   6 ( 1 )   e03259 - e03259   2020.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Aquaporin-4 (AQP4) is a water conducting membrane integral protein channel which is widely expressed in the astrocyte system of the brain. During the development of the AQP4 positron emission tomography (PET) imaging agent [11C]TGN-020 (N-(1,3,4-thiadiazol-2-yl)pyridine-3-[11C]-carboxamide), significant radioligand uptake was observed in the skull, where there was no known distribution of any aquaporin family proteins. Herein we confirmed via a newly developed method for bone-tissue immunohistology, a hitherto unrecognized distribution of AQP4, and not AQP1, in the skull. Other bony structures, by contrast, showed virtually no uptake of [11C]TGN-020, and likewise, do not express either AQP4 or AQP1. Immunohistological analysis demonstrated that the AQP4 expression in the skull is restricted to the diploë. Consequently, we suspect AQP4 plays a pivotal role in the formation and maintenance of yellow marrow and the diploë. However, elucidating the exact nature of that role will require further studies.

    DOI: 10.1016/j.heliyon.2020.e03259

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  • Age-related increase in GABAA receptor distribution in the prefrontal cortex Reviewed International journal

    Masanobu Tobinaga, Yuji Suzuki, Hidehiko Fujinaka, Tetsuo Ozawa, Takashi Nakajima

    Journal of Clinical Neuroscience   64   106 - 110   2019.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Profound insight into age-related changes in γ-aminobutyric acid type A receptor (GABAA-R) distribution using iodine-123-iomazenil single photon emission computed tomography (IMZ-SPECT) can contribute to accurate in vivo evaluation. We evaluated the age-related changes in prefrontal cortex (PFC), which is the key region involved in various neurological and psychiatric diseases. In this study, IMZ-SPECT imaging data of 21 healthy males with an age range of 22-59 (mean, 38 ± 12) years were analyzed using three-dimensional stereotactic surface projection (3D-SSP). The Z-score images of the younger group (age < 40, n = 11) and the older group (age ≥ 40, n = 10) were compared. Subsequently, the mean RI-count ratios calculated for each Brodmann area (BA) by stereotactic extraction estimation method were compared between these groups. Thereafter, linear regression analysis between age and RI-count ratio was performed for all enrolled subjects. In the result, IMZ accumulation increased in bilateral BA10, 11, and the BA47 (left hemisphere) in the older group compared with the younger group. Furthermore, regression analysis demonstrated a significant positive correlation between age and RI-count ratio in these areas. Our findings indicate that GABAA-R distribution in the PFC relatively increases with age. Therefore, we concluded that the age-related changes should be considered to accurately evaluate pathophysiology of neurological and psychiatric diseases.

    DOI: 10.1016/j.jocn.2019.03.044

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  • A case of atraumatic tetanus developed initially with worsening headache in a woman regularly cared for chronic headache at an outpatient clinic Reviewed International journal

    Masanobu Tobinaga, Yuji Suzuki, Takashi Nakajima

    Clinical Case Reports   7 ( 3 )   486 - 490   2019.3

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    We presented a case of atraumatic tetanus developed initially with severe headache. Headache may be a clue to the presence of tetanus. Clinicians who usually treat headache should consider the possibility of tetanus in patients who present with symptoms that are severe and atypical for a given patient.

    DOI: 10.1002/ccr3.2024

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  • Developmental abnormalities of the brain exposed to childhood maltreatment detected by diffusion tensor imaging Reviewed

    Kenichi Yamada, Yuji Suzuki, Makiko Okuyama, Masaki Watanabe, Tsutomu Nakada

    Neurological Research   41 ( 1 )   19 - 25   2019.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Informa UK Limited  

    DOI: 10.1080/01616412.2018.1522413

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  • Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo 19F-Magnetic Resonance Spectroscopic Imaging. Reviewed International journal

    Vincent J Huber, Hironaka Igarashi, Satoshi Ueki, Mika Terumitsu-Tsujita, Chikako Nito, Ken Ohno, Yuji Suzuki, Kosuke Itoh, Ingrid L Kwee, Tsutomu Nakada

    Contrast media & molecular imaging   2019   8908943 - 8908943   2019

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    Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote the blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of the most severe side effects of thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes in the distribution of MMPs in the brain. Here, we developed a new 19F-molecular ligand, TGF-019, for visualizing the distribution of MMPs in vivo using 19F-magnetic resonance spectroscopic imaging (19F-MRSI). We demonstrated TGF-019 has sufficient sensitivity for the specific MMPs suspected in evoking HT during ischemic stroke, i.e., MMP2, MMP9, and MMP3. We then utilized it to assess those MMPs at 22 to 24 hours after experimental focal cerebral ischemia on MMP2-null mice, as well as wild-type mice with and without the systemic administration of the recombinant tissue plasminogen activator (rt-PA). The 19F-MRSI of TGN-019-administered mice showed high signal intensity within ischemic lesions that correlated with total MMP2 and MMP9 activity, which was confirmed by zymographic analysis of ischemic tissues. Based on the results of this study, 19F-MRSI following TGN-019 administration can be used to assess potential therapeutic strategies for ischemic stroke.

    DOI: 10.1155/2019/8908943

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  • Advances and Challenges in Assessing 2-Hydroxyglutarate in Gliomas by Magnetic Resonance Spectroscopy: A Short Review Reviewed

    Manabu Natsumeda, Hironaka Igarashi, Kunio Motohashi, Yuji Suzuki, Masaki Ohkubo, Kouichirou Okamoto, Masaki Watanabe, Tsutomu Nakada, Yukihiko Fujii

    Neuropsychiatry (London)   8 ( 6 )   1831 - 1838   2018.7

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  • Aquaporin Positron Emission Tomography Differentiates Between Grade III and IV Human Astrocytoma Reviewed International journal

    Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Satoshi Kurabe, Kouichirou Okamoto, Hiroshi Aoki, Hiroki Kitaura, Akiyoshi Kakita, Yukihiko Fujii, Vincent J Huber, Hironaka Igarashi, Ingrid L Kwee, Tsutomu Nakada

    Neurosurgery   82 ( 6 )   842 - 846   2018.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    <title>Abstract</title>
    <sec>
    <title>BACKGROUND</title>
    Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade.


    </sec>
    <sec>
    <title>OBJECTIVE</title>
    To examine the utility of aquaporin positron emission tomography (PET) for differentiating between astrocytoma grade III and grade IV using the AQP radioligand [11C]TGN-020.


    </sec>
    <sec>
    <title>METHODS</title>
    Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10 healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues of astrocytoma patients were examined for histopathological grading using the WHO classification standard and expression of AQP1 and AQP4 immunohistochemically.


    </sec>
    <sec>
    <title>RESULTS</title>
    Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs 1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P &amp;lt; .001) for both tumor grades. Importantly, mean standardized uptake values of astrocytoma grade IV were significantly higher than grade III (P &amp;lt; .01).


    </sec>
    <sec>
    <title>CONCLUSION</title>
    Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as a noninvasive diagnostic tool would lead to advancements in the management of these malignant brain tumors.


    </sec>

    DOI: 10.1093/neuros/nyx314

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  • MRI characteristics of the glia limitans externa: A 7T study Reviewed

    Kiyotaka Suzuki, Kenichi Yamada, Kazunori Nakada, Yuji Suzuki, Masaki Watanabe, Ingrid L. Kwee, Tsutomu Nakada

    MAGNETIC RESONANCE IMAGING   44   140 - 145   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Purpose: To perform a systematic analysis of the intrinsic contrast parameters of the FLAIR hyperintense rim (FHR), a thin layer of high intensity covering the entire surface of the cerebral cortex detected on fluid-attenuated inversion recovery (FLAIR) sequence T-2 weighted imaging performed on a 7T system, in an attempt to identify its anatomical correlate.
    Methods: Fast spin echo inversion recovery (FSE-IR) and cardiac-gated fast spin echo (FSE) images were obtained with defined parameters in eight normal volunteers on a 7 T MRI system to determine T-2 and proton density, T-1 characteristics. K-means clustering analysis of parameter sets was performed using MATLAB version R2015b for the purpose of identifying the cluster reflecting FHR. The results were subsequently confirmed by independent component analysis (ICA) based on Ti behavior on FSE-IR using a MATLAB script of FastICA algorithm.
    Results: The structure giving rise to FHR was found to have a unique combination of intrinsic contrast parameters of low proton density, long T-2, and disproportionally short T-5. The findings are in strong agreement with the functional and structural specifics of the glia limitans externa (GLE), a structure composed of snuggled endfeet of astrocytes containing abundant aquaporin-4 (AQP-4), the main water channel of the brain.
    Conclusion: Intrinsic contrast parameters of FHR reflect structural and functional specifics of the GLE, and their values are highly dependent on the physiologic functionality of AQP-4. Microscopic imaging on a 7T system and analysis of GLE contrast parameters can be developed into a method for evaluating AQP-4 functionality.

    DOI: 10.1016/j.mri.2017.08.012

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  • Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a H-1-MR spectroscopy study Reviewed

    Mami Shimizu, Yuji Suzuki, Kenichi Yamada, Satoshi Ueki, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    PEDIATRIC RESEARCH   82 ( 5 )   749 - 752   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    BACKGROUND: The aim of the present study was to investigate maturational changes in glutamate (Glu) in the human cerebral cortex from childhood to young adulthood using 3.0-Tesla proton magnetic resonance spectroscopy (H-1-MRS), which is capable of quantifying Glu in vivo.
    METHODS: Normal volunteers comprising 11 children (aged 4-13 years) and 11 young adults (aged 18-33 years) participated in the study. Single-voxel point-resolved spectroscopy (PRESS, repetition time/echo time = 2,000/80 ms) was performed on the frontal and occipital cortices, and the Glu-to-creatine ratio (Glu/Cr) and N-acetylaspartate-to-creatine ratio (NAA/Cr) were determined.
    RESULTS: In both the frontal and occipital cortices, Glu/Cr was significantly lower during young adulthood relative to that during childhood. NAA/Cr did not differ significantly between the two age groups.
    CONCLUSION: This study has provided objective evidence that cerebral cortical Glu/Cr decreases between childhood and young adulthood. The observed decrease in Glu/Cr may reflect the simultaneous occurrence of maturational changes, such as changes in cortical microstructure and the intercellular compartmentation of Glu metabolism.

    DOI: 10.1038/pr.2017.101

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  • Slow accumulations of neural activities in multiple cortical regions precede self-initiation of movement: an event-related fMRI study. Reviewed

    Sakata H, Itoh K, Suzuki Y, Nakamura K, Watanabe M, Igarashi H, Nakada T

    eNEURO   2017.10

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    DOI: 10.1523/ENEURO.0183-17

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  • Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. Reviewed International journal

    Tsutomu Nakada, Ingrid L Kwee, Hironaka Igarashi, Yuji Suzuki

    International journal of molecular sciences   18 ( 8 )   2017.8

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    The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pressure created by the systolic force of the heart, essential for interstitial circulation and lymphatic flow in systemic circulation, is effectively impeded from propagating into the interstitial fluid inside the BBB by the tightly sealed endothelium of brain capillaries. Instead, fluid dynamics inside the BBB is realized by aquaporin-4 (AQP-4), the water channel that connects astrocyte cytoplasm and extracellular (interstitial) fluid. Brain interstitial fluid dynamics, and therefore AQP-4, are now recognized as essential for two unique functions, namely, neurovascular coupling and glymphatic flow, the brain equivalent of systemic lymphatics.

    DOI: 10.3390/ijms18081798

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  • Magnetic Resonance Imaging of Neurotransmitter-Related Molecules Reviewed

    Hironaka Igarashi, Satoshi Ueki, Ken Ohno, Masaki Ohkubo, Yuji Suzuki

    JOURNAL OF NIPPON MEDICAL SCHOOL   84 ( 4 )   160 - 164   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MEDICAL ASSOC NIPPON MEDICAL SCH  

    Molecular imaging implies the method capable of pictorially displaying distribution of target molecules and their relative concentration in space. In clinical medicine, where non-invasiveness is mandatory, diagnostic molecular imaging has been considered virtually identical to positron emission tomography (PET). However, there is another powerful, apparently underutilized molecular imaging, namely, proton magnetic resonance spectroscopic imaging (H-1-MRSI). The technique can detect target molecules endogenous in brain in virtue of their own specific resonance frequencies (chemical shift) and can create quantitative images of each molecule. H-1-MRSI is conventionally utilized for imaging relatively easily detectable molecules such as N-acetyl-aspartate or lactate. More recently, however, the method is extended into imaging of more challenging molecules such as glutamate or gamma-aminobutyric acid (GABA). In this small review, we summarize basic concept of H-1-MRSI and introduce an advanced technique, i.e. chemical exchange saturation transfer magnetic resonance imaging (CEST MRI), which made realistic glutamate imaging in vivo possible.

    DOI: 10.1272/jnms.84.160

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  • Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for regional Cerebral Blood Flow and Glymphatic Flow Reviewed

    Nakada T, Kwee IL, Igarashi H, Suzuki Y

    Int. J. Mol. Sci   2017.8

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    DOI: 10.3390/ijms18081798

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  • ABNORMAL DISTRIBUTION OF GABA(A) RECEPTORS IN BRAIN OF DUCHENNE MUSCULAR DYSTROPHY PATIENTS Reviewed

    Yuji Suzuki, Shinya Higuchi, Izumi Aida, Takashi Nakajima, Tsutomu Nakada

    MUSCLE & NERVE   55 ( 4 )   591 - 595   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Introduction: In this study we sought to: (1) determine the distribution of GABA(A) receptors (GABA(A)-Rs) in the brain of Duchenne muscular dystrophy (DMD) patients; and (2) ascertain if the distribution pattern correlates with cognitive dysfunction. Methods: Fourteen DMD patients [young adult (n = 7, 18-25 years old) and older adult (n = 7, 30-37 years old) groups] and 16 age-matched normal volunteers participated. GABA(A)-R distribution was assessed using I-123-IMZ-SPECT. Neuropsychological assessments were performed using 3 different test batteries, the WAIS-III, WMS-R, and Wisconsin Card Sorting Test (WCST). Results: All DMD patients showed significant decline in I-123-IMZ uptake in the prefrontal cortex (P &lt; 0.05). Although no differences were detected in the WAIS-III and WMS-R, the WCST scores of DMD patients (2.8 +/- 1.9) were significantly lower (P &lt; 0.01) than those of normal volunteers (5.4 +/- 0.7). Both abnormalities were more pronounced in older adult patients. Conclusion: The findings demonstrate that DMD is accompanied by a reduction in the prefrontal cortex distribution of GABA(A)-Rs.

    DOI: 10.1002/mus.25383

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  • Visualization of the Intimal Flap in Intracranial Arterial Dissection Using High-Resolution 3T MRI Reviewed

    Masahiro Uemura, Kenshi Terajima, Yuji Suzuki, Masaki Watanabe, Yasuhisa Akaiwa, Shinichi Katada, Kouichirou Okamoto, Masatoyo Nishizawa, Hironaka Igarashi, Tsutomu Nakada

    JOURNAL OF NEUROIMAGING   27 ( 1 )   29 - 32   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-BLACKWELL  

    BACKGROUND AND PURPOSE: Presence of an intimal flap is a critical imaging finding in diagnosing intracranial artery dissection (ICAD). Recent reports showed that high-resolution magnetic resonance imaging (MRI) was better at identifying intimal flaps as compared with routine MRI techniques used in clinical settings. However, no current standardized sequence for high-resolution MRI without gadolinium enhancement produces images of satisfactory quality with clinically tolerable scanning times. This study evaluated a nonenhanced high-resolution fast spin echo (HR-FSE) MRI sequence for visualizing intimal flaps in patients with ICAD.
    SUBJECTS AND METHODS: Three patients with ICAD underwent plain MRI examination using a 2-dimensional T2-weighted FSE imaging sequence optimized for our 3T system (in-plane pixel size, .23 mm x .23 mm; slice thickness 3 mm with no interslice gap), as well as scanning with conventional modalities, including CT angiography, magnetic resonance angiography, and digital subtraction angiography. We assessed whether these imaging methods could visualize an intimal flap and/or double lumen sign in the participants and compared the results between HR-FSE and the other modalities.
    RESULTS: HR-FSE images clearly showed intimal flaps and double lumen signs in all 3 patients, whereas the conventional modalities identified a double lumen sign in only 2 of the 3 patients.
    CONCLUSIONS: The present method of optimized HR-FSE imaging with a 3T system improved visualization of intimal flaps and should thus be considered for assessing patients with suspected ICAD that cannot be definitively diagnosed by conventional imaging modalities.

    DOI: 10.1111/jon.12380

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  • 3DAC PROPELLER: An overly underused powerful MRI modality Reviewed

    Nakada T, Suzuki K, Suzuki Y, Nakada K, Kwee IL

    Anatomy Physiol Biochem Int J   2017

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    DOI: 10.19080/APBIJ.2018.04.555626

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  • The Posterior Limb of the Internal Capsule as the Subcortical Transitional Zone of the Anterior and Posterior Circulations: Insights from Human 7T MRI Reviewed

    Satoshi Kurabe, Kouichirou Okamoto, Kiyotaka Suzuki, Hisothi Matsuzawa, Masaki Watanabe, Yuji Suzuki, Tsutomu Nakada, Yukihiko Fujii

    CEREBROVASCULAR DISEASES   41 ( 5-6 )   256 - 264   2016

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:KARGER  

    Background: In patients with cerebral infarction, identifying the distribution of infarction and the relevant artery is essential for ascertaining the underlying vascular pathophysiological mechanisms and preventing subsequent stroke. However, visualization of the basal perforating arteries (BPAs) has had limited success, and simultaneous viewing of background anatomical structures has only rarely been attempted in living human brains. Our study aimed at identifying the BPAs with 7T MRI and evaluating their distribution in the subcortical structures, thereby showing the clinical significance of the technique. Methods: Twenty healthy subjects and 1 patient with cerebral infarction involving the posterior limb of the internal capsule (ICpost) and thalamus underwent 3-dimensional fast spoiled gradient-echo sequence as time-of-flight magnetic resonance angiography (MRA) at 7T with a submillimeter resolution. The MRA was modified to detect inflow signals from BPAs, while preserving the background anatomical signals. BPA stems and branches in the subcortical structures and their origins were identified on images, using partial maximum intensity projection in 3 dimensions. Results: A branch of the left posterior cerebral artery (PCA) in the patient ran through both the infarcted thalamus and ICpost and was clearly the relevant artery. In 40 intact hemispheres in healthy subjects, 571 stems and 1,421 branches of BPAs were detected in the subcortical structures. No significant differences in the numbers of stems and branches were observed between the intact hemispheres. The numbers deviated even less across subjects. The distribution analysis showed that the subcortical structures of the telencephalon, such as the caudate nucleus, anterior limb of the internal capsule, and lenticular nucleus, were predominantly supplied by BPAs from the anterior circulation. In contrast, the thalamus, belonging to the diencephalon, was mostly fed by BPAs from the posterior circulation. However, compared with other subcortical structures, the ICpost, which marks the anatomical boundary between the telencephalon and the diencephalon, was supplied by BPAs with significantly more diverse origins. These BPAs originated from the internal carotid artery (23.1%), middle cerebral artery (38.5%), PCA (17.3%), and the posterior communicating artery (21.1%). Conclusions: The modified MRI method allowed the detection of the relevant BPA within the infarcted in the stroke survivor as well as the BPAs in the subcortical structures of living human brains. Based on in vivo BPA distribution analyses, the ICpost is the transitional zone of the anterior and posterior cerebral circulations. (C) 2016 S. Karger AG, Basel

    DOI: 10.1159/000443538

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  • Reduced CSF Water Influx in Alzheimer's Disease Supporting the beta-Amyloid Clearance Hypothesis Reviewed

    Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Hironaka Igarashi, Kensaku Kasuga, Yuichi Yokoyama, Takeshi Ikeuchi, Masatoyo Nishizawa, Ingrid L. Kwee, Tsutomu Nakada

    PLOS ONE   10 ( 5 )   e0123708   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PUBLIC LIBRARY SCIENCE  

    Objective
    To investigate whether water influx into cerebrospinal fluid (CSF) space is reduced in Alzheimer's patients as previously shown in the transgenic mouse model for Alzheimer's disease.
    Methods
    Ten normal young volunteers (young control, 21-30 years old), ten normal senior volunteers (senior control, 60-78 years old, MMSE &gt;= 29), and ten Alzheimer's disease (AD) patients (study group, 59-84 years old, MMSE: 13-19) participated in this study. All AD patients were diagnosed by neurologists specializing in dementia based on DSM-IV criteria. CSF dynamics were analyzed using positron emission tomography (PET) following an intravenous injection of 1,000 MBq [O-15]H2O synthesized on-line.
    Results
    Water influx into CSF space in AD patients, expressed as influx ratio, (0.755 +/- 0.089) was significantly reduced compared to young controls (1.357 +/- 0.185; p &lt; 0.001) and also compared to normal senior controls (0.981 +/- 0.253, p &lt; 0.05). Influx ratio in normal senior controls was significantly reduced compared to young controls (p &lt; 0.01).
    Conclusion
    Water influx into the CSF is significantly reduced in AD patients. beta-amyloid clearance has been shown to be dependent on interstitial flow and CSF production. The current study indicates that reduction in water influx into the CSF may disturb the clearance rate of beta-amyloid, and therefore be linked to the pathogenesis of AD.

    DOI: 10.1371/journal.pone.0123708

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  • N-acetylaspartate Decrease in Acute Stage of Ischemic Stroke:A Perspective from Experimental and Clinical Studies Reviewed

    Hironaka Igarashi, Yuji Suzuki, Vincent J. Huber, Masahiro Ida, Tsutomu Nakada

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   14 ( 1 )   13 - 24   2015

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JPN SOC MAGNETIC RESONANCE IN MEDICINE  

    N-acetylaspartate (NAA) appears in a prominent peak in proton magnetic resonance spectroscopy (H-1-MRS) of the brain. Exhibition by NAA of time-dependent attenuation that reflects energy metabolism during the acute stage of cerebral ischemia makes this metabolite a unique biomarker for assessing ischemic stroke. Although magnetic resonance (MR) imaging is a powerful technique for inspecting the pathological changes that occur during ischemic stroke, biomarkers that directly reflect the drastic metabolic changes associated with acute-stage ischemia are strongly warranted for appropriate therapeutic decision-making in daily clinical settings. In this review, we provide a brief overview of NAA metabolism and focus on the use of attenuation in NAA as a means for assessing the pathophysiological changes that occur during the acute stage of ischemic stroke.

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  • Water influx into cerebrospinal fluid is significantly reduced in senile plaque bearing transgenic mice, supporting beta-amyloid clearance hypothesis of Alzheimer's disease Reviewed

    Hironaka Igarashi, Yuji Suzuki, Ingrid L. Kwee, Tsutomu Nakada

    NEUROLOGICAL RESEARCH   36 ( 12 )   1094 - 1098   2014.12

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    Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of water influx into the peri-capillary (Virchow-Robin) space through aquaporin 4 (AQP-4). This water flow is believed to have the functionality equivalent to the systemic lymphatic system and plays a critical role in beta-amyloid clearance. Using a newly developed molecular imaging technique capable of tracing water molecules, in vivo, water influx into the CSF was quantitatively analyzed in senile plaque (SP) bearing transgenic Alzheimer's disease (AD) model mice. The results unequivocally demonstrated that water influx into CSF is significantly impaired in SP-bearing transgenic mice, the degree of which being virtually identical to that previously observed in AQP-4 knockout mice. The study strongly indicates that disturbance in AQP-4-based water flow and, hence, impairment in beta-amyloid clearance play a significant role in SP formation.

    DOI: 10.1179/1743132814Y.0000000434

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  • Pixel values of [15O]H2O PET images with OSEM algorithm depending on numbers of subset and iteration times: Comparative assessment to FBP Reviewed

    Rie Yamanoi, Kouichirou Okamoto, Kazunori Kawamura, Masaki Ohkubo, Yuji Suzuki, Yukihiro Nakamura

    Kakuigaku   51 ( 4 )   373 - 382   2014

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    To investigate a potential application of ordered subsets expectation maximization (OSEM) algorithm for clinical [15O]H2O PET studies, region of interest (ROI) measurements were performed on both images with OSEM and fitered back projection (FBP). Forty OSEM images were reconstructed with variable combinations of numbers of the subset (1-40) and iteration times (2-12). PET scans were acquired using a PET/CT scanner (Discovery ST Elite, GE), and 3T-MRI images were obtained for fusion images. The mean values were measured on the frontal cortical regions in the middle cerebral artery distribution. Differences of the values between the OSEM and FBP were evaluated as %Error. Relationship between ROI mean values and the iteration times was investigated on the OSEM images. The smallest %Error 0.4% was measured in the combination of the subset number 10 and iteration times 8 [10, 8], and in that of [28, 2]. The mean values were stable with iteration number 8 or more. OSEM image with [28, 2] was reconstructed in a shorter time (2.5 min) than that with [10, 8] (6 min). OSEM image with [28, 2] was superior to that with [10, 8] in the qualitative evaluation. The mean values on OSEM images with [28, 2] were comparable with those on FBP images with little artifacts and higher spatial resolution. OSEM with optimal parameter setting seemed applicable for both quantitative and qualitative [15O]H2O PET studies.

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  • Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Reviewed International journal

    Hironaka Igarashi, Mika Tsujita, Yuji Suzuki, Ingrid L Kwee, Tsutomu Nakada

    Neuroreport   24 ( 6 )   324 - 8   2013.4

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    The effects of the aquaporin-4 (AQP-4) inhibitor TGN-020 on regional cerebral blood flow (rCBF) was examined in wild-type (WT) and AQP-4 knockout (KO) mice in vivo. Although baseline absolute rCBF of WT and KO mice were equivalent (158.9 ± 17.7 and 155.5 ± 10.4 ml/100 g/min, respectively), TGN-020 produced a significant increase in rCBF compared with saline-treated WT mice (control), reaching a plateau 20 min after administration (118.45 ± 8.13%, P<0.01). TGN-020 showed no effect on KO mice, supporting the concept that the observed increase in rCBF in WT mice was AQP-4 dependent. Administration of acetazolamide (positive control) produced an even greater increase in rCBF in WT compared with TGN-020 and a similar response in KO mice as well, reaching a sustained plateau 5 min after administration (138.50 ± 9.75 and 138.52 ± 9.76%, respectively, P<0.01 compared with baseline or saline-treated control mice). The study demonstrated that AQP-4 plays a role in regulation of rCBF.

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  • Aquaporin-4 Positron Emission Tomography Imaging of the Human Brain: First Report Reviewed

    Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Vincent J. Huber, Mika Tsujita, Tsutomu Nakada

    JOURNAL OF NEUROIMAGING   23 ( 2 )   219 - 223   2013.4

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    BACKGROUND AND PURPOSE Aquaporin 4 (AQP-4) is the most abundant aquaporin isoform in the brain. Alterations in its expression and distribution have been correlated with the progression of several clinical disorders; however, the specific roles of AQP-4 in those disorders are not well understood. Visualizing AQP-4 in vivo is expected to provide fresh insights into its roles in disease pathology, as well as aiding the clinical assessment of those disorders. METHODS We developed a 11C-labeled analogue of the AQP-4 ligand TGN-020 (2-nicotinamido-1,3,4-thiadiazole) suitable for in vivo positron emission tomography (PET) imaging. RESULTS In the present study, we report the first PET images of AQP-4 in the human brain. The results unequivocally demonstrated a specific distribution pattern for AQP-4 within the brain, namely, the subpial and perivascular endfeet of astrocytes. The choroid plexus, where both AQP-4 and AQP-1 are expressed, also showed substantial uptake of the ligand. CONCLUSIONS Based on these initial results, we believe [11C]TGN-020 PET will be valuable in determining the role of AQP-4 in disease progression, and for the clinical assessment of water homeostasis under various settings.

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  • In-vivo analysis for human brain maturation using MRI

    Yuji Suzuki

    Clinical Neurology   53 ( 11 )   1100 - 1103   2013

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    The evaluation of human brain maturation in vivo is a significant problem for pediatric neurologists. MRI, especially Diffusion Tensor Imaging (DTI) and 1H-MR Spectroscopy (MRS), can be a powerful method to solve this problem. A decrease in three eigenvalues (Δλ1 &lt
    Δλ2 ≓ Δλ3) and an increase in Fractional Anisotropy, as a function of brain maturation, was identified in the frontal and parietal white matter using DTI, which is a non-invasive imaging technique capable of providing a quantitative view of neural fibers and micro-environmental alterations during the myelination period. MRS, a powerful technique capable non-invasively quantifying N-acetyl-aspartate (NAA), a marker for neurons, glutamate (Glu), an excitatory neurotransmitter, and creatine (Cr), revealed a decrease in the Glu/Cr ratio, but found no changes to the NAA/Cr ratio with maturational changes in brain networks, such as a decrease in cortical synaptic density (refinement). Therefore, we suggest these two MRI techniques, DTI and MRS, can be used to provide direct, non-invasive information on brain maturation in vivo, which we believe will help elucidate the pathophysiology behind neurodevelopmental disorders that disrupt normal brain maturation.

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  • Analysis of ascending spinal tract degeneration in cervical spondylotic myelopathy using 3D anisotropy contrast single-shot echo planar imaging on a 3.0-T system Reviewed

    Takaaki Urakawa, Hitoshi Matsuzawa, Yuji Suzuki, Naoto Endo, Ingrid L. Kwee, Tsutomu Nakada

    JOURNAL OF NEUROSURGERY-SPINE   15 ( 6 )   648 - 653   2011.12

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    Object. The authors assessed the role of 3D anisotropy contrast (3DAC) in evaluating specific ascending tract degeneration in patients with cervical spondylotic myelopathy (CSM).
    Methods. The authors studied 10 patients (2 women, 8 men; mean age 59.8 +/- 14.6 years) with CSM and spinal cord compression below the C2-3 disc level, as well as 10 healthy control individuals (3 women, 7 men; mean age 42.0 +/- 24.1 years). Images of the cervical cord at the C2-3 level were obtained using a 3.0-T MR imaging system.
    Results. Three-dimensional anisotropy contrast imaging clearly made possible tract-by-tract analysis of the fasciculus cuneatus, fasciculus gracilis, and spinocerebellar tract. Tract degeneration identified using 3DAC showed good correlation with a decline in fractional anisotropy. Degeneration of the fasciculus gracilis detected by "vector contrast" demonstrated a good correlation with Nurick grades.
    Conclusions. The study unambiguously demonstrated that 3DAC imaging is capable of assessing ascending tract degeneration in patients with CSM. Degeneration of an individual tract can be easily identified as a vector contrast change on the 3DAC image, a reflection of quantitative changes in anisotropism, similar to fractional anisotropy. Excellent correlation between Nurick grades and fasciculus gracilis degeneration suggests potential application of 3DAC imaging for tract-by-tract clinical correlation. (DOI: 10.3171/2011.7.SPINE10843)

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  • Development of a Novel Ligand, [C-11]TGN-020, for Aquaporin 4 Positron Emission Tomography Imaging Reviewed

    Yukihiro Nakamura, Yuji Suzuki, Mika Tsujita, Vincent J. Huber, Kenichi Yamada, Tsutomu Nakada

    ACS CHEMICAL NEUROSCIENCE   2 ( 10 )   568 - 571   2011.10

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    Aquaporin 4 (AQP4), the most abundant isozyme of the water specific membrane transporter aquaporin family, has now been implicated to play a significant role in the pathogenesis of various disease processes of the nervous system from epilepsy to Alzheimer&apos;s disease. Considering its clinical relevance, it is highly desirable to develop a noninvasive method for the quantitative analysis of AQP distribution in humans under clinical settings. Currently, the method of choice for such diagnostic examinations continues to be positron emission tomography (PET). Here, we report the successful development of a PET ligand for AQP4 imaging based on TGN-020, a potent AQP4 inhibitor developed previously in our laboratory. Utilizing [C-11]TGN-020, PET images were successfully generated in wild type and AQP4 null mice, providing a basis for future evaluation regarding its suitability for clinical studies.

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  • 細菌性髄 膜炎の6例 Reviewed

    信太 知, 簗詰紀子, 帯金克行, 鈴木雄治, 板倉 治, 越 和子, 梶井直文

    江別市立病院誌   3   3 - 6   2010

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  • Feasibility study of single region lambda chart analysis for pyramidal tract physiology Reviewed

    Y Suzuki, H Matsuzawa, T Nakada

    JOURNAL OF NEUROLOGY   250 ( 10 )   1185 - 1189   2003.10

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    Diffusion characteristics of the pyramidal tract were assessed in nine patients who had clinical evidence of pyramidal tract dysfunction, utilizing lambda chart analysis (LCA). The underlying pathologic process of tract dysfunction was varied and included Pelizaeus-Merzbacher disease (PMD), Alexander disease, adrenoleukodystrophy (adreno-myeloneuropathy (AMD) type and cerebral type), amyotrophic lateral sclerosis (ALS), and Wallerian degeneration (WD). While pyramidal tract diffusion characteristics in WD indicated a pathological process characterized by replacement of normal fibers by smaller cellular component such as degenerated small fibers and/or gliosis, pyramidal tract diffusion characteristics in patients with PMD, Alexander disease, and adreno leukodystrophy of the cerebral type indicated a pathological process characterized by replacement of normal fibers by larger cellular components such as spheroids or edematous space. Pyramidal tract diffusion characteristics of patients with ALS or adrenoleukodystrophy of AMD type were relatively intact suggesting a pathological process characterized by relatively preserved structural architecture. These findings are highly consistent with known pathophysiological indices and indicate the feasibility of the clinical utility of LCA for assessing pyramidal tract physiology.

    DOI: 10.1007/s00415-003-0175-4

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  • Absolute eigenvalue diffusion tensor analysis for human brain maturation Reviewed

    Y Suzuki, H Matsuzawa, IL Kwee, T Nakada

    NMR IN BIOMEDICINE   16 ( 5 )   257 - 260   2003.8

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    The absolute eigenvalues of the diffusion tensor of white matter in sixteen normal subjects in two groups representing the early developmental stage (ages 1-10 years, n = 8) and young adult stage (ages 18-34 years, n = 8) were assessed using a high-field (3.0 T) magnetic resonance (MR) system. All three eigenvalues, including the largest eigenvalue, decreased significantly with brain maturation. The rate of the decline in the two small eigenvalues was, however, much higher than that of the largest eigenvalue, resulting in an actual increase in fractional anisotropy, a commonly measured relative index. The data demonstrate that an increase in anisotropy associated with brain maturation represents a significant decline in the small eigenvalue components, rather than an increase in the largest eigenvalue. The observed pattern of eigenvalue changes is best explained by the simultaneous occurrence of two of several independent phenomena within the axonal microenvironment during the myelination process, namely, (1) decline in unrestricted water content in extra-axonal space, and (2) increase in apparent diffusivity within the axon. Copyright (C) 2003 John Wiley Sons, Ltd.

    DOI: 10.1002/nbm.848

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  • Principal Eigenvector Imaging (PEvecI): Comparison of Deterministic vs. Optical Methods

    H Matsuzawa, Y Suzuki, H Saito, T Nakada

    Integrated Human Brain Science   233 - 237   2000

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  • Phenotypic variability in a family with a mitochondrial DNA T8993C mutation Reviewed

    Y Suzuki, T Wada, T Sakai, Y Ishikawa, R Minami, N Tachi, S Saitoh

    PEDIATRIC NEUROLOGY   19 ( 4 )   283 - 286   1998.10

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    Two patients are described in a family with a mitochondrial DNA T8993C point mutation. Patient 1, the proband, was a 4-year-old male, and his clinical features were consistent with those of Leigh syndrome, including lactic acidosis, motor development delay, and symmetric basal ganglia lesions on magnetic resonance imaging (MRI). His mental development was delayed mildly, but he has not demonstrated neurologic deterioration. Patient 2 was his maternal aunt. She developed her first neurologic sign at 18 months of age, thereafter her development ceased and regressed. She had lost her head control and become bedridden by 4 years of age and died at 20 years of age, demonstrating a more severe clinical course than that of Patient 1, Analysis of mitochondrial DNA from peripheral leukocytes of Patient 1 revealed a T8993C mutation of 99%. Patient 2 was demonstrated to have the same mutation at high abundance (99%) in the frozen myocardium and in the formaldehyde preserved spinal cord, with only 18% mutant mitochondrial DNA present in the formaldehyde preserved sciatic nerve. The mother of Patient 1, who was phenotypically normal (sister of Patient 2), had 35% mutant mitochondrial DNA in peripheral leukocytes, The authors' findings suggest that T8993C phenotypes are highly variable and that the proportion of the mutant mitochondrial DNA may vary among tissues and not correlate well with clinical severity. (C) 1998 by Elsevier Science Inc. All rights reserved.

    DOI: 10.1016/S0887-8994(98)00070-8

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  • ガンマグロブリン療法,ステロイドパルス療法を施行したRasmussen脳炎の一例 Reviewed

    坂井多恵子, 香坂忍, 鈴木雄治, 和田敬仁, 斉藤伸治

    てんかんをめぐって   18   71 - 77   1998

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  • 還流血管の同定および経過観察に非侵襲的画像診断法が有用であった肺葉内肺分画症の1乳児例 Reviewed

    松川祐子, 鈴木雄治, 久保秀司, 岡野素彦, 三河 誠, 石川信義, 臼渕浩明, 竹内恵理保, 俣野 順, 山城勝重

    小児科臨床   2165 - 2169   1994.10

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  • 胸痛を契機に発見し得た孤立性右肺動脈欠損症の1例 Reviewed

    久保秀司, 鈴木雄治, 松川祐子, 岡野素彦, 三河 誠, 石川信義

    小児科臨床   6   76 - 82   1994.6

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  • てんかんの発作間欠期・発作時脳波を読む

    ( Role: Contributor ,  正常人にみられる突発波)

    診断と治療社  2007 

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  • プラダー・ウィリ症候群にみられる行動発達特性に関連した脳形態・機能的結合の特徴

    山田謙一, 渡辺将樹, 鈴木清隆, 松澤等, 鈴木雄治

    第50回日本小児神経学会学術集会   2020.8

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  • Gray matter microstructural alteration of the brain in individuals with Prader-Willi syndrome: a 7T MRI study

    Kenichi Yamada, Kiyotaka Suzuki, Masaki Watanabe, Yuji Suzuki

    The 10th IPWSO Conference (International Prader-Willi Syndrome Conference)   2019.11

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  • Endogenous brain activities preceding self-initiated movements

    2019.7

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  • 内因性の意図に基づく自己開始運動に先行する脳活動

    酒多 穂波, 伊藤 浩介, 鈴木 雄治, 中村 克樹, 渡辺 将樹, 五十嵐 博中, 中田 力

    基礎心理学研究   37 ( 2 )   222 - 222   2019.3

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  • Glymphatic systemの機能画像

    Clinical Neuroscience   37   46 - 48   2019.1

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  • 内因性の意図に基づく自己開始運動に先行する脳活動

    酒多穂波, 伊藤浩介, 鈴木雄治, 中村克樹, 渡辺将樹, 五十嵐博中, 中田力

    日本基礎心理学会第37回大会   2018.12

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  • Entropy-based functional magnetic resonance imaging

    Kiyotaka Suzuki, Yuji Suzuki, Masaki Fukunaga, Honami Sakata, Tsutomu Nakada

    Entropy 2018: From Physics to Information Sciences and Geometry   2018.5

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  • MMP特異的19Fトレーサーの開発と虚血性脳血管障害モデルへの応用

    五十嵐 博中, Vincent J Huber, 照光 実加, 植木 智志, 鈴木 雄治, 中田 力

    第30回 臨床MR脳機能研究会   2018.4

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  • 無鎮静小児MRI脳撮像におけるゼロテスラ・プレパレーションシステムの有用性

    山田謙一, 鈴木雄治, 植木智志, 渡辺将樹, 鈴木清隆, 五十嵐博中, 中田力

    第30回臨床MR脳機能研究会   2018.4

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  • Relationship between reduction of water influx into CSF and senile plaque formation (β-amyloid)

    Yuji Suzuki

    47th Annual meeting of Society for Neuroscience   2017.11

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  • Endogenously initiated movements are preceded by neural activities in multiple cortical regions: an event-related fMRI study

    Honami Sakata, Kosuke Itoh, Yuji Suzuki, Katsuki Nakamura, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    47th Annual meeting of Society for Neuroscience   2017.11

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  • Construction of a database of the normal GABAA receptor brain SPECT to visualize neuronal loss in neurodegenerative diseases

    M. Tobinaga, T. Hayashi, H. Endo, T. Ikeda, K. Ohta, Y. Yonemochi, I. Aida, H. Fujinaka, Y. Suzuki, T. Nakajima

    Journal of the Neurological Sciences   381   957 - 957   2017.10

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    DOI: 10.1016/j.jns.2017.08.2694

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  • 内因性の意図に基づく運動に先行する神経活動

    酒多穂波, 伊藤浩介, 鈴木雄治, 中村克樹, 渡辺将樹, 五十嵐博中, 中田力

    第29回 臨床MR脳機能研究   2017.4

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  • 事象関連fMRIによる自由な意図の神経基盤の検討

    酒多穂波, 伊藤浩介, 鈴木雄治, 中村克樹, 渡辺将樹, 五十嵐博中, 中田力

    第6回 生理研-霊長研-脳研 合同シンポジウム   2017.3

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  • Reduction of water influx into CSF in Alzheimer’s disease

    Yuji Suzuki

    Alzheimer's disease: Narrowing the gap between basic science and clinical application   2017.3

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  • ニューロサイエンスの最新情報 アクアポリンのPET

    鈴木 雄治, 五十嵐 博中, 中田 力

    Clinical Neuroscience   34 ( 12 )   1394 - 1395   2016.12

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  • 19F-3FDG MRIを用いたアルツハイマー病モデルマウス脳代謝マッピング

    藤原 秀元, 五十嵐 博中, 鈴木 雄治, 大久保 真樹, 中村 亨弥, 辻田 実加, 藤井 幸彦, 中田 力

    脳循環代謝   28 ( 1 )   161 - 161   2016.11

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  • 3T-MRIを用いた頭蓋内血管異常の臨床的検討

    上村 昌寛, 寺島 健史, 鈴木 雄治, 二宮 格, 赤岩 靖久, 五十嵐 博中, 中田 力, 西澤 正豊

    臨床神経学   55 ( Suppl. )   S414 - S414   2015.12

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  • Anisometropia and anisometropic amblyopia ipsilateral to the ptotic eye in congenital ptosis children

    Satoshi Ueki, Yuji Suzuki, Takako Hanyu, Tetsuhisa Hatase, Takeo Fukuchi

    The 12th Meeting of International Strabismological Association(ISA)   2014.12

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  • 拡散テンソル画像を用いた小児期被虐待経験者の脳発達評価

    山田 謙一, 鈴木 雄治, 奥山 眞紀子, 中田 力

    第26回臨床MR脳機能研究会   2014.4

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  • PATIENTS SHOW SIGNIFICANT DISTURBANCE IN WATER INFLUX INTO CSF SPACE, STRONGLY SUPPORTING BETA-AMYLOID CLEARANCE HYPOTHESIS

    Tsutomu Nakada, Yuji Suzuki, Ingrid L Kwee

    Alzheimer's & Dementia: The Journal of the Alzheimer's Association   4 ( 10 )   7   2014

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  • Developmental abnormalities exposed to childhood maltreatment detected by diffusion tensor imaging

    Kenichi Yamada, Yuji, Suzuki, Makiko Okuyama, Tsutomu Nakada

    Society for Neuroscience Annual meeting   2013.11

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  • MRIをもちいた発達に対するアプローチ Invited

    鈴木雄治

    臨床神経学   53 ( 11 )   1100 - 1103   2013

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  • Skull Is Skull, and Not Simply Another Bony Structure

    Tsutomu Nakada, Yuji Suzuki, Yukihiro Nakayama, Vincent Huber

    Annals of Neurology   70   2011.10

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  • 小児大脳型adrenoleukodystrophy患者脳の発症極早期からの経時的評価 3.0テスラMR装置によるDTIと1H-MRSI解析

    山田 謙一, 鈴木 雄治, 清水 満美, 五十嵐 博中, 松澤 等, 大久保 真樹, 中田 力

    脳と発達   43 ( 4 )   332 - 332   2011.7

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  • ヒト大脳成熟に伴う glutamate濃度の低下: 1H-MRSを用いた研究

    清水満美,鈴木雄治,山田謙一,五十嵐博中,中田 力

    2011.6

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  • ヒト大脳成熟に伴う glutamate 濃度の低下―1 H-MRS を用いた研究―

    清水満美, 鈴木雄治, 山田謙一, 中田 力

    2011.5

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  • In vivo aquaporin imaging of wild type and aquaporin-4 null mice by positron emission tomography (PET) utilizing a newly developed 11C labeled ligand, 11C-TGN-020

    Y. Nakamura, Y. Suzuki, M. Tsujita, V. J. Huber, I. L. Kwee, T. Nakada

    Society for Neuroscience Annual meeting   2010.11

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  • 小児大脳型Adrenoleukodystrophy患者脳の発症極早期からの経時的評価:3.0テスラMR装置によるDTIとH1-MRSI解析

    山田謙一, 鈴木雄治, 清水満美, 五十嵐博中, 松澤等, 大久保真樹, 中田力

    日本小児神経学会甲信越地方会   2010.11

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  • デュシェンヌ型筋ジストロフィー患者における神経心理学的検査及び頭部画像検査の検討

    清水満美, 山田謙一, 鈴木雄治, 藤田基, 飯田知子, 高橋勇弥, 木下悟, 藤中英彦, 富沢修一, 中島孝, 東條恵

    日本小児神経学会学術集会   2010.6

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  • ヒト大脳成熟に伴うglutamateの濃度の低下 H1MRSを用いた研究

    清水満美, 鈴木雄治, 山田謙一, 中田力

    日本ヒト脳機能マッピング学会   2010.6

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  • 拡散テンソル画像法及びH-MRSIを用いた小児大脳型副腎白質ジストロフィー患者脳の経時的評価

    鈴木雄治, 山田謙一, 五十嵐博中, 大久保真樹, 松澤等, 中田力

    日本小児神経学会学術集会   2010.5

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  • 画像だけでないMRIの世界~機能、微細構造、発達へのアプローチ Invited

    鈴木雄治

    第11回成育医療臨床懇話会   2009.12

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  • MRIの進歩は医療に何をもたらすか Invited

    鈴木雄治, 松澤等

    新医療   6   40 - 43   2009

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    Authorship:Lead author   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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  • Tractographyの原理 Invited

    鈴木雄治, 中田力

    神経内科   70 ( 3 )   293 - 298   2009

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  • 脳画像診断で得られる情報 Invited

    中田力, 鈴木雄治

    Clinical Neuroscience   27   386 - 388   2009

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  • 拡散テンソル画像の有用性・中枢伝導路の画像 Invited

    鈴木雄治, 松澤等, 中田力

    Annual Review 神経   42 - 50   2009

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    Authorship:Lead author, Corresponding author   Language:Japanese  

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  • Toxic shock syndrome に副腎皮質ステ ロイドが著効を示した一例.

    末田慶太朗, 鈴木雄治, 信太 知, 梶井直文

    第260回日本小児科学会北海道地方会   2004.5

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  • アレルギー性紫斑病に合併した蛋白漏出 性胃腸症にステロイドが著効を示した一例.

    末田慶太朗, 鈴木雄治, 信太 知, 梶井直文

    第259回日本小児科学会北海道地方会   2004.1

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  • Alteration in small eigenvalue components signify brain maturation in humans

    Yuji Suzuki, Tsutomu Nakada

    32th Annual meeting of Society for Neuroscience   2001.10

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  • 3テスラ超高磁場磁気共鳴画像による拡散テンソル解析を用いた,神経変性疾患における非侵襲的軸索機能解

    寺島 健史, 鈴木 雄治, 松澤 等, 原 賢寿, 相馬 芳明, 辻 省次, 中田 力

    臨床神経学   40 ( 12 )   1467 - 1467   2000.12

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    Language:Japanese   Publisher:(一社)日本神経学会  

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  • ミトコンドリアDNA8993T→G変異を有するLeigh脳症の1例

    鈴木雄治, 斉藤伸治, 和田敬仁, 坂井多恵子, 香坂忍, 内藤悦雄

    臨牀小児医学   47 ( 1 )   57   1999

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  • DNAメチル化テストによるAngelman症候群およびPrader-Willi症候群の分子診

    斉藤伸治, 和田敬仁, 鈴木雄治, 坂井多恵子, 香坂忍

    臨牀小児医学   46 ( 6 )   287   1998

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  • ムンプスウイルス感染が起因したと思われる全身型若年性関節リウマチ (Still病) の1例

    鈴木雄治, 松川祐子, 久保秀司, 岡野素彦, 三河誠, 石川信義

    臨牀小児医学   43(6):   360   1995

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  • Needlemachin industry in Kwan, China

    SUZUKI Y.

    The journal of geography   48   1 - 7   1994.12

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    Language:Japanese   Publisher:Tokyo Gakugei University  

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  • A Report of Geographical Excursion in Hachioji and Onkata, Tokyo

    SUZUKI Y.

    The journal of geography   44   44 - 45   1990.3

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    Language:Japanese   Publisher:Tokyo Gakugei University  

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Presentations

  • Relationship between reduction of water influx into CSF and senile plaque formation (β-amyloid)

    鈴木雄治

    第7回 新潟脳研-霊長研-生理研合同シンポジウム  2018.3 

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    Event date: 2018.3

    Presentation type:Oral presentation (general)  

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  • MRIを用いた発達へのアプローチ Invited

    鈴木雄治

    第21回酸素ダイナミクス研究会  2017.9 

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    Event date: 2017.9

    Presentation type:Oral presentation (invited, special)  

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  • デュシェンヌ型におけるGABAA受容体発現異常と認知機能障害 Invited

    鈴木雄治

    第3回 筋ジストロフィーのCNS障害研究会  2016.12 

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    Event date: 2016.12

    Presentation type:Oral presentation (invited, special)  

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  • ヒトの脳MRI最新技術ーMRIを用いた発達評価と病態解明への試み Invited

    鈴木雄治

    第59回 日本獣医画像診断学会  2016.6 

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    Event date: 2016.6

    Presentation type:Oral presentation (invited, special)  

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  • 画像からみる発達・発達障害 Invited

    鈴木雄治

    新潟県医師会学術講演会  2015.6 

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    Event date: 2015.6

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • 画像学から迫る筋ジストロフィーの中枢神経-基礎と応用 Invited

    鈴木雄治

    第 2 回 Dystrophinopathy の CNS 障害に関する研究会  2014.1 

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    Event date: 2014.1

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  • 神経疾患におけるMR撮像法の最先端 「MRIを用いた発達に対するアプローチ」 Invited

    鈴木雄治

    第54回日本神経学会学術大会  2013.5 

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    Event date: 2013.5 - 2013.6

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  • 小児科医からみた画像診断装置の可能性―高磁場MRIを中心に Invited

    鈴木雄治

    第54回日本神経学会総会  2012.5 

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    Event date: 2012.5

    Presentation type:Oral presentation (invited, special)  

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  • MRで観察する発達 Invited

    鈴木雄治

    第22回臨床MR脳機能研究会  2011.3 

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    Event date: 2011.3

    Presentation type:Symposium, workshop panel (nominated)  

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  • 画像だけでないMRIの世界~機能、微細構造、発達へのアプローチ Invited

    鈴木雄治

    第11回成育医療臨床懇話会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (invited, special)  

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  • 読み書き障害の医学的評価-functional MRI Invited

    鈴木雄治

    第13回日本LD学会  2004.8 

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    Event date: 2004.8

    Presentation type:Symposium, workshop panel (nominated)  

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  • Development of Aquaporin PET Ligands for Clinical Application~ Glioma ~

    Yuji Suzuki

    2014.3 

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Research Projects

  • 活動時機能画像のエントロピー解析を用いた発達性読み書き障害の脳活動の解明研究

    Grant number:20K20514  2020.7 - 2025.3

    日本学術振興会  科学研究費助成事業 挑戦的研究(開拓)  挑戦的研究(開拓)

    鈴木 雄治

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    Authorship:Principal investigator 

    Grant amount:\25740000 ( Direct Cost: \19800000 、 Indirect Cost:\5940000 )

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  • 安静時超高磁場MRI時系列エントロピー解析による自閉症者情報処理メカニズムの解明

    Grant number:17H02191  2017.4 - 2022.3

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    鈴木 雄治, 鈴木 清隆, 山田 謙一, 中田 力

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    Authorship:Principal investigator 

    Grant amount:\15990000 ( Direct Cost: \12300000 、 Indirect Cost:\3690000 )

    自閉症者の社会性の障害は、定型発達者が無意識に処理してしまうような環境の変化や刺激に対しても敏感に反応し、処理すべき情報の重み付けによる取捨選択が出来ないため情報が氾濫してしまい、外部に対する反応が鈍化すると考えられる。本研究では、脳の刺激受容性の度合いが安静時(無刺激時)の賦活パターンの複雑さ(高エントロピー状態) に反映されるとの考えに基づき、超高磁場磁気共鳴画像法(7T-MRI)による高分解能脳画像時系列データを用いて、自閉症脳における安静時賦活パターンのエントロピーを評価する。平成30年度までに、 ①撮像環境の整備 ②撮像条件の最適化及び撮像プロトコルの確定 ③解析法の検討 の3項目につき、下記に記載したように具体的な解決に取り組んだ。 ①参加者、特に自閉症者が安静状態で撮像を受けられる環境を整えるため、初年度に整備した撮像時の騒音対策(ヘッドホンによるノイズキャンセリングシステムを導入)を用いて、撮像の際に生じる騒音の軽減を可能にする撮像方法を確立する。それらの条件にあわせて、MRIプレパレーションシステム「ゼロテスラ」を用いた撮像前の練習環境を整えた。 ②昨年度に行った撮像条件の最適化を更にすすめる。傾斜磁場のslew rateの低減などのパルスシークエンスのプログラム変更を行いながら撮像条件を最適化し、自閉症児にも適応可能なrs-fMRIの撮像プロトコルを確定する。今後、順次MRI撮像の参加者(健常ボランティア)の撮像を開始する。 ③エントロピー解析は主成分以外の固有値分布に着目しているが、この解析方法が機能解析に有用であることを、3T-MRI撮像データを用いて確認した。本年度は、成人及び小児(順次自閉症児を含め)実際のrs-fMRIデータを用いて、シミュレーションの結果と対比し並列計算機によるプログラム開発を進める。

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  • 7T MRIを用いたプラダー・ウィリ症候群における行動発達特性の脳基盤解明

    Grant number:17K10049  2017.4 - 2020.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    山田 謙一, 鈴木 雄治, 鈴木 清隆, 渡辺 将樹

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    Authorship:Coinvestigator(s) 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    本研究の目的は、プラダー・ウィリ症候群(PWS)における行動発達特性に関連した脳組織微細構造の発達異常を、当事者を対象に非侵襲的に可視化して、病態を解明することである。PWSは特徴的な行動発達特性(過食、強迫性、衝動制御障害等)を呈するが、その脳発達基盤は不明である。症候に寄与しうる脳部位において組織微細構造の成熟異常が存在するとの仮説に基づき、7T MRIを用いた脳画像解析により、脳部位特異的な成熟異常の手掛かりを探索し、PWSにおける脳の生物学的理解への貢献を目指す。
    今年度は、前年度に示唆された、拡散の非ガウス分布を前提とした解析にむけて、7T MRI撮像条件パラメータの最適化から開始した。超高磁場特性への考慮と同時に撮像時間の短縮を優先的事項としたパラメータを探索したところ、代表的な指標(例;diffusion kurtosis imaging, NODDI等)による計算画像の算出ならびに患者対照間の比較が可能であることが確認できた。一方で、小児や発達障害をもつ参加者が無鎮静撮像に参加できるための環境設定と撮像手順構築は、前年度に確立した手法が継承された。これらを基に、PWS当事者と健常ボランティア各々10名以上の撮像を行った。その結果、複数の脳部位において、指標値の差異を検出可能であることが確認された。
    次年度は、撮像を更に進めると同時に、PWSの脳に特徴的な差異の抽出を進める。更に、臨床特徴と照合することで行動発達特性との関連を探索する。

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  • Elucidation of pathophysiology of iNPH by dynamics analysis of water molecule

    Grant number:16K15643  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Suzuki Yuji

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    Authorship:Principal investigator 

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

    The purpose of this study is to directly evaluate the dynamics of water molecules in CNS in idiopathic normal pressure hydrocephalus (iNPH) for elucidating the pathophysiology. In recent years, attention has focused on cerebrospinal fluid regulatory mechanisms via the Glymphatic System including Interstitial flow, which can also be called the lymphatic system of the brain for the production and absorption of cerebrospinal fluid. We analyze the dynamics of water molecules from the analysis method using PET that it is deeply involved in iNPH showed a clear reduction in cortex-to-ventricular flow, and shunt surgery proved to improve the flow.

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