研究者詳細 - 川嵜　圭祐

論文 - 川嵜　圭祐

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Optogenetically‐induced sustained hypothalamic hyperexcitability impairs memory via thalamic spread

Masaki Sonoda, Hisao Aimi, Keisuke Kawasaki, Haruo Toda, Shinobu Hirai, Masao Horie, Reiko Meguro, Eishi Asano, Haruo Okado, Shigeki Kameyama, Tetsuya Yamamoto, Isao Hasegawa

Epilepsia 2025年3月

掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

Abstract

Objective

Clinical investigators have hypothesized that interictal epileptiform discharges (IEDs) generated by hypothalamic hamartoma (HH) lead to cognitive dysfunction in patients with drug‐resistant gelastic seizures. Herein we provide causal evidence supporting this hypothesis by demonstrating that excitatory neural bursts, when propagating from the HH to the mediodorsal thalamus during the encoding period, impair working memory.

Methods

By employing channelrhodopsin‐2 photostimulation, we induced excessive neural excitation in Long‐Evans rats, resembling IEDs, at the axon terminals of the lateral hypothalamus projecting toward the mediodorsal thalamus and prelimbic cortex. We recorded local field potentials (LFPs) at these sites and assessed the performance of working memory tasks with and without photostimulation. Utilizing support vector machine analysis on LFP trials under sham photostimulation, we identified the neural correlates of successful task performance. Through mixed model analyses, we evaluated the impacts of photostimulation timing and the alteration in LFP amplitude induced by photostimulation on task performance.

Results

Ten rats completed operant conditioning using a spout lever system after receiving an average of 70.7 days of training, at a rate of 135.2 trials per day. During sham photostimulation, successful trials were associated with a shorter duration of the working memory maintenance period, as well as an augmentation in the 10‐ to 14‐Hz LFP amplitude at the mediodorsal thalamus and prelimbic cortex during the memory encoding phase. Photostimulation at the mediodorsal thalamus during encoding reduced the odds of a trial being successful by 0.19. Conversely, excessive mediodorsal thalamus LFP augmentation induced by photostimulation during encoding increased the odds of a trial being unsuccessful by 1.04.

Significance

Excessive neural excitation, specifically propagating from the lateral hypothalamus to the mediodorsal thalamus during encoding, alters physiological neural activity and transiently impairs working memory. This study clarifies the pathophysiological mechanism underlying cognitive disabilities associated with working memory impairment in HH‐related epileptic encephalopathy.

DOI： 10.1111/epi.18321

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Mapping information flow between the inferotemporal and prefrontal cortices via neural oscillations in memory retrieval and maintenance. 国際誌

Tao Zhou, Keisuke Kawasaki, Takafumi Suzuki, Isao Hasegawa, Anna Wang Roe, Hisashi Tanigawa

Cell reports 42 ( 10 ) 113169 - 113169 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Interaction between the inferotemporal (ITC) and prefrontal (PFC) cortices is critical for retrieving information from memory and maintaining it in working memory. Neural oscillations provide a mechanism for communication between brain regions. However, it remains unknown how information flow via neural oscillations is functionally organized in these cortices during these processes. In this study, we apply Granger causality analysis to electrocorticographic signals from both cortices of monkeys performing visual association tasks to map information flow. Our results reveal regions within the ITC where information flow to and from the PFC increases via specific frequency oscillations to form clusters during memory retrieval and maintenance. Theta-band information flow in both directions increases in similar regions in both cortices, suggesting reciprocal information exchange in those regions. These findings suggest that specific subregions function as nodes in the memory information-processing network between the ITC and the PFC.

DOI： 10.1016/j.celrep.2023.113169

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Chemogenetic attenuation of cortical seizures in nonhuman primates. 国際誌

Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, Asumi Orihara, Kei Oyama, Takeshi Matsuo, Ken-Ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto

Nature communications 14 ( 1 ) 971 - 971 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Epilepsy is a disorder in which abnormal neuronal hyperexcitation causes several types of seizures. Because pharmacological and surgical treatments occasionally interfere with normal brain function, a more focused and on-demand approach is desirable. Here we examined the efficacy of a chemogenetic tool-designer receptors exclusively activated by designer drugs (DREADDs)-for treating focal seizure in a nonhuman primate model. Acute infusion of the GABAA receptor antagonist bicuculline into the forelimb region of unilateral primary motor cortex caused paroxysmal discharges with twitching and stiffening of the contralateral arm, followed by recurrent cortical discharges with hemi- and whole-body clonic seizures in two male macaque monkeys. Expression of an inhibitory DREADD (hM4Di) throughout the seizure focus, and subsequent on-demand administration of a DREADD-selective agonist, rapidly suppressed the wide-spread seizures. These results demonstrate the efficacy of DREADDs for attenuating cortical seizure in a nonhuman primate model.

DOI： 10.1038/s41467-023-36642-6

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動物種間の皮質脳波応答比較に基づく顔処理の流暢性効果の検討

宍倉基文, 大貫良幸, 石下洋平, 川合謙介, 叶賀卓, 三木治憲, 川嵜圭祐, 宮川尚久, 林隆介

Vision 35 ( 1 ) 23 - 24 2023年1月

Decoding distributed oscillatory signals driven by memory and perception in the prefrontal cortex

Hisashi Tanigawa, Kei Majima, Ren Takei, Keisuke Kawasaki, Hirohito Sawahata, Kiyoshi Nakahara, Atsuhiko Iijima, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

Cell Reports 39 ( 2 ) 110676 - 110676 2022年4月

Theory of mind tested by implicit false belief: a simple and full‐fledged mental state attribution

Isao Hasegawa, Jun Egawa, Keisuke Kawasaki, Taketsugu Hayashi, Ryota Akikawa, Toshiyuki Someya, Isao Hasegawa

The FEBS Journal 2022年1月

Prediction-Related Frontal-Temporal Network for Omission Mismatch Activity in the Macaque Monkey. 国際誌

Yuki Suda, Mariko Tada, Takeshi Matsuo, Keisuke Kawasaki, Takeshi Saigusa, Maho Ishida, Tetsuo Mitsui, Hironori Kumano, Kenji Kirihara, Takafumi Suzuki, Kenji Matsumoto, Isao Hasegawa, Kiyoto Kasai, Takanori Uka

Frontiers in psychiatry 13 557954 - 557954 2022年

記述言語：英語掲載種別：研究論文（学術雑誌）

Sensory prediction is considered an important element of mismatch negativity (MMN) whose reduction is well known in patients with schizophrenia. Omission MMN is a variant of the MMN which is elicited by the absence of a tone previously sequentially presented. Omission MMN can eliminate the effects of sound differences in typical oddball paradigms and affords the opportunity to identify prediction-related signals in the brain. Auditory predictions are thought to reflect bottom-up and top-down processing within hierarchically organized auditory areas. However, the communications between the various subregions of the auditory cortex and the prefrontal cortex that generate and communicate sensory prediction-related signals remain poorly understood. To explore how the frontal and temporal cortices communicate for the generation and propagation of such signals, we investigated the response in the omission paradigm using electrocorticogram (ECoG) electrodes implanted in the temporal, lateral prefrontal, and orbitofrontal cortices of macaque monkeys. We recorded ECoG data from three monkeys during the omission paradigm and examined the functional connectivity between the temporal and frontal cortices by calculating phase-locking values (PLVs). This revealed that theta- (4-8 Hz), alpha- (8-12 Hz), and low-beta- (12-25 Hz) band synchronization increased at tone onset between the higher auditory cortex and the frontal pole where an early omission response was observed in the event-related potential (ERP). These synchronizations were absent when the tone was omitted. Conversely, low-beta-band (12-25 Hz) oscillation then became stronger for tone omission than for tone presentation approximately 200 ms after tone onset. The results suggest that auditory input is propagated to the frontal pole via the higher auditory cortex and that a reciprocal network may be involved in the generation of auditory prediction and prediction error. As impairments of prediction may underlie MMN reduction in patients with schizophrenia, an aberrant hierarchical temporal-frontal network might be related to this pathological condition.

DOI： 10.3389/fpsyt.2022.557954

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皮質脳波（ECoG）法とfMRIによるサル・ヒトの前頭葉・側頭葉の神経生理学的検証

飯島淳彦, 劉南希, 加世堂竜太郎, 渡辺卓爾, 中野広輝, 松尾健, 川嵜圭祐, 足立雄哉, 田中慎吾, 中原潔, 長谷川功

生体医工学 Annual60 ( Abstract ) 111_1 - 111_1 2022年

記述言語：日本語出版者・発行元：公益社団法人日本生体医工学会

本研究では，ヒトおよびマカクザル（ニホンザル）の前頭葉と側頭葉に留置した皮質脳波（ECoG）電極から記録した神経活動と，ヒトを対象としたfMRIの脳機能画像を用いて，高次機能に関連した神経回路の検証を行なっている．特に，言語機能に関わる脳領域の推定と各領域の連関，視覚的な認知に寄与する神経ネットワークについての研究成果を報告する．

DOI： 10.11239/jsmbe.annual60.111_1

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Macaques Exhibit Implicit Gaze Bias Anticipating Others' False-Belief-Driven Actions via Medial Prefrontal Cortex. 査読国際誌

Taketsugu Hayashi, Ryota Akikawa, Keisuke Kawasaki, Jun Egawa, Takafumi Minamimoto, Kazuto Kobayashi, Shigeki Kato, Yukiko Hori, Yuji Nagai, Atsuhiko Iijima, Toshiyuki Someya, Isao Hasegawa

Cell reports 30 ( 13 ) 4433 - 4444 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

The ability to infer others' mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) to others, has been considered to be uniquely hominid and to accompany the activation of a distributed brain network. We challenge the taxon specificity of this ability and identify the causal brain locus by introducing an anticipatory-looking FB paradigm combined with chemogenetic neuronal manipulation in macaque monkeys. We find spontaneous gaze bias of macaques implicitly anticipating others' FB-driven actions. Silencing of the medial prefrontal neuronal activity with inhibitory designer receptor exclusively activated by designer drugs (DREADDs) specifically eliminates the implicit gaze bias while leaving the animals' visually guided and memory-guided tracking abilities intact. Thus, neuronal activity in the medial prefrontal cortex could have a causal role in FB-attribution-like behaviors in the primate lineage, emphasizing the importance of probing the neuronal mechanisms underlying theory of mind with relevant macaque animal models.

DOI： 10.1016/j.celrep.2020.03.013

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Deep Learning for Channel-Agnostic Brain Decoding across Multiple Subjects

Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani

8th International Winter Conference on Brain-Computer Interface, BCI 2020 2020年2月

マカクザルにおける他者の誤信念理解に内側前頭前野が因果的役割を果たす

秋川諒太, 林剛丞, 川嵜圭祐, 江川純, 南本敬史, 小林和人, 加藤成樹, 堀由紀子, 永井裕司, 飯島淳彦, 染矢俊幸, 長谷川功

日本生理学雑誌 82 ( 1 ) 10 - 10 2020年2月

硬膜上高密度多点電極を用いたサル一次視覚野における網膜視野の再構成

土屋貴大, 飯島淳彦, 川嵜圭祐, 鈴木隆文, 長谷川功, 中原潔

日本生理学雑誌 82 ( 1 ) 11 - 12 2020年2月

物体素材に対するサル下側頭葉皮質における皮質脳波応答

三木治憲, 安斎健太, 澤山正貴, 松尾健, 鈴木隆文, 岡谷貴之, 飯島淳彦, 長谷川功, 川嵜圭祐

日本生理学雑誌 82 ( 1 ) 11 - 11 2020年2月

マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

林剛丞, 江川純, 川崎圭祐, 秋川諒太, 長谷川功, 飯島淳彦, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S603 - S603 2019年6月

Deep Learning for Natural Image Reconstruction from Electrocorticography Signals.

Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani

2331 - 2336 2019年

Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion 査読

Haruo Toda, Keisuke Kawasaki, Sho Sato, Masao Horie, Kiyoshi Nakahara, Asim K. Bepari, Hirohito Sawahata, Takafumi Suzuki, Haruo Okado, Hirohide Takebayashi, Isao Hasegawa

Scientific Reports 8 ( 1 ) 7678 2018年12月

Heterogeneous Redistribution of Facial Subcategory Information Within and Outside the Face-Selective Domain in Primate Inferior Temporal Cortex. 査読国際誌

Naohisa Miyakawa, Kei Majima, Hirohito Sawahata, Keisuke Kawasaki, Takeshi Matsuo, Naoki Kotake, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

Cerebral cortex (New York, N.Y. : 1991) 28 ( 4 ) 1416 - 1431 2018年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

The inferior temporal cortex (ITC) contains neurons selective to multiple levels of visual categories. However, the mechanisms by which these neurons collectively construct hierarchical category percepts remain unclear. By comparing decoding accuracy with simultaneously acquired electrocorticogram (ECoG), local field potentials (LFPs), and multi-unit activity in the macaque ITC, we show that low-frequency LFPs/ECoG in the early evoked visual response phase contain sufficient coarse category (e.g., face) information, which is homogeneous and enhanced by spatial summation of up to several millimeters. Late-induced high-frequency LFPs additionally carry spike-coupled finer category (e.g., species, view, and identity of the face) information, which is heterogeneous and reduced by spatial summation. Face-encoding neural activity forms a cluster in similar cortical locations regardless of whether it is defined by early evoked low-frequency signals or late-induced high-gamma signals. By contrast, facial subcategory-encoding activity is distributed, not confined to the face cluster, and dynamically increases its heterogeneity from the early evoked to late-induced phases. These findings support a view that, in contrast to the homogeneous and static coarse category-encoding neural cluster, finer category-encoding clusters are heterogeneously distributed even outside their parent category cluster and dynamically increase heterogeneity along with the local cortical processing in the ITC.

DOI： 10.1093/cercor/bhx342

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Decoding value related signals represented in multiple areas of the prefrontal cortex using ECoG electrodes 査読

Sakagami Masamichi, Tanaka Shingo, Kawasaki Keisuke, Hasegawa Isao, Suzuki Takafumi

INTERNATIONAL JOURNAL OF PSYCHOLOGY 51 874 2016年7月

Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex 査読

Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

NATURE COMMUNICATIONS 7 11827 2016年6月

皮質脳波法で見た下側頭葉皮質の階層的な視覚情報処理ネットワーク

川嵜圭祐

生体医工学 54 ( 28 ) S291 - S291 2016年

記述言語：日本語出版者・発行元：一般社団法人日本生体医工学会

<p>Converging evidence suggests that cortical processing is performed in a hierarchical manner. In the primate object vision, visual information is thought to be processed along the sequence of areas. We identified the direct physiological evidence for the cortical hierarchical processing as propagating activity patterns by employing electrocorticography (ECoG) in monkey, which enable us to record neural activity from wide cortical areas at high spatiotemporal resolution. Quantification of the propagating wave by symbolic local transfer entropy (SLTE) revealed both feed-forward and feedback components. We also found that SLTE topography changed during the visual stimulation. We also examined hierarchal nature of the process by comparing the ECoG activity pattern with the output from each layer of a deep neural network model. The output explained the specific spatiotemporal aspect of the ECoG activity. These results add the physiological insights of the hierarchical processing in the ventral visual stream.</p>

DOI： 10.11239/jsmbe.54Annual.S291

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Alternating Zones Selective to Faces and Written Words in the Human Ventral Occipitotemporal Cortex 査読

Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Kei Majima, Hiroshi Masuda, Hiroatsu Murakami, Naoto Kunii, Yukiyasu Kamitani, Shigeki Kameyama, Nobuhito Saito, Isao Hasegawa

CEREBRAL CORTEX 25 ( 5 ) 1265 - 1277 2015年5月

Decoding visual object categories from temporal correlations of ECoG signals 査読

Kei Majima, Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Nokihito Saito, Isao Hasegawa, Yukiyasu Kamitani

NEUROIMAGE 90 74 - 83 2014年4月

Super multi-channel recording systems with UWB wireless transmitter for BMI 査読

Takafumi Suzuki, Hiroshi Ando, Takeshi Yoshida, Hirohito Sawahata, Keisuke Kawasaki, Isao Hasegawa, Kojiro Matsushita, Masayuki Hirata, Toshiki Yoshimine, Kenichi Takizawa

2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) 2014 5208 - 5211 2014年

Simultaneous Recording of Single-Neuron Activities and Broad-Area Intracranial Electroencephalography: Electrode Design and Implantation Procedure 査読

Takeshi Matsuo, Kensuke Kawai, Takeshi Uno, Naoto Kunii, Naohisa Miyakawa, Kenichi Usami, Keisuke Kawasaki, Isao Hasegawa, Nobuhito Saito

NEUROSURGERY 73 ( 2 Suppl Operative ) 146 - 154 2013年12月

Super Multi-Channel Recording System for BMI

Suzuki Takafumi, Ando Hiroshi, Yoshida Takeshi, Sawahata Hirohito, Kawasaki Keisuke, Hasegawa Isao, Matsushita Kojiro, Hirata Masayuki, Yoshimine Toshiki, Takizawa Kenichi

生体医工学 51 M - 2-M-2 2013年

LOCAL AND RETROGRADE GENE TRANSFER INTO PRIMATE NEURONAL PATHWAYS VIA ADENO-ASSOCIATED VIRUS SEROTYPE 8 AND 9 査読

Y. Masamizu, T. Okada, K. Kawasaki, H. Ishibashi, S. Yuasa, S. Takeda, I. Hasegawa, K. Nakahara

NEUROSCIENCE 193 249 - 258 2011年10月

Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols 査読

Takeshi Matsuo, Keisuke Kawasaki, Takahiro Osada, Hirohito Sawahata, Takafumi Suzuki, Masahiro Shibata, Naohisa Miyakawa, Kiyoshi Nakahara, Atsuhiko Iijima, Noboru Sato, Kensuke Kawai, Nobuhito Saito, Isao Hasegawa

Frontiers in Systems Neuroscience 5 ( 2011 ) 34 2011年5月

Intrasulcal ECoG approach to cortico-cortical connectivity using electrical stimulation-induced evoked potentials in macaques 査読

Osada Takahiro, Molcard Antoine J, Matsuo Takeshi, Kawasaki Keisuke, Adachi Yusuke, Miyamoto Kentaro, Watanabe Tomomi, Hasegawa Isao, Miyashita Yasushi

NEUROSCIENCE RESEARCH 71 E97 2011年

Intrasulcal electrocorticography in macaque monkeys 査読

Kawasaki Keisuke, Matsuo Takeshi, Osada Takahiro, Sawahata Hirohito, Suzuki Takafumi, Shibata Masahiro, Miyakawa Naohisa, Nakahara Kiyoshi, Sato Noboru, Kawai Kensuke, Saito Nobuhito, Hasegawa Isao

NEUROSCIENCE RESEARCH 71 E413 - E414 2011年

Effects of Familiarity on Neural Activity in Monkey Inferior Temporal Lobe 査読

Britt Anderson, Ryan E. B. Mruczek, Keisuke Kawasaki, David Sheinberg

CEREBRAL CORTEX 18 ( 11 ) 2540 - 2552 2008年11月

Learning to recognize visual objects with microstimulation in inferior temporal cortex 査読

Keisuke Kawasaki, David L. Sheinberg

JOURNAL OF NEUROPHYSIOLOGY 100 ( 1 ) 197 - 211 2008年7月

Effects of long-term object familiarity on event-related potentials in the monkey 査読

Jessie J. Peissig, Jedediah Singer, Keisuke Kawasaki, David L. Sheinberg

CEREBRAL CORTEX 17 ( 6 ) 1323 - 1334 2007年6月

Initial saccades predict manual recognition choices in the monkey 査読

David L. Sheinberg, Jessie J. Peissig, Keisuke Kawasaki, Ryan E. B. Mruczek

VISION RESEARCH 46 ( 22 ) 3812 - 3822 2006年10月

Presumed inhibitory neurons in the macaque inferior temporal cortex: Visual response properties and functional interactions with adjacent neurons 査読

H Tamura, H Kaneko, K Kawasaki, Fujita, I

JOURNAL OF NEUROPHYSIOLOGY 91 ( 6 ) 2782 - 2796 2004年6月

Inhibitory mechanisms underlying stimulus-selective responses of inferior temporal neurons 査読

H Tamura, H Kaneko, K Kawasaki, Fujita, I

NEURAL BASIS OF EARLY VISION 11 245 - 249 2003年

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