Updated on 2026/01/07

写真a

 
HAYASHI Kazunao
 
Organization
Graduate School of Medical and Dental Sciences Associate Professor
Title
Associate Professor
Other name(s)
Niigata university
External link

Degree

  • Ph.D ( 2011.3   Niigata University )

Research Interests

  • Biliary tract

  • Pancreas

Research Areas

  • Life Science / Gastroenterology  / 胆膵分野

Research History (researchmap)

  • Niigata University   Medical and Dental Hospital Department of Endoscopy   Associate Professor   Ph.D

    2025.6

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Research History

  • Niigata University   Department of Endoscopy, University Medical and Dental Hospital   Associate Professor

    2025.6

  • Niigata University   University Medical and Dental Hospital Gastroenterology   Assistant Professor

    2018.4 - 2025.5

  • Niigata University   University Medical and Dental Hospital Advanced Disaster Medical and Emergency Critical Care Center   Specially Appointed Assistant Professor

    2009.10 - 2010.3

  • Niigata University   University Medical and Dental Hospital Emergency and Critical Care Unit   Specially Appointed Assistant Professor

    2009.5 - 2009.9

Education

  • Niigata University   Medical department   医歯学総合研究科

    2007.4 - 2011.3

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  • Niigata University   Medical department   医学科

    1998.4 - 2004.3

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Professional Memberships

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Papers

  • Delayed pancreatic ductal leakage after EUS-FNA for autoimmune pancreatitis Reviewed International journal

    Satoshi Ikarashi, Atsunori Tsuchiya, Kazunao Hayashi, Shuji Terai

    ENDOSCOPIC ULTRASOUND   8 ( 4 )   277 - 278   2019.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4103/eus.eus_55_18

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  • Multiple Endocrine Neoplasia Type 1-Related Acute Pancreatitis Reviewed International journal

    Shunsaku Takahashi, Kenya Kamimura, Hiroyuki Abe, Yukari Watanabe, Kazunao Hayashi, Kenichi Mizuno, Takashi Yamamoto, Manabu Takeuchi, Masaaki Natsui, Shuji Terai

    PANCREAS   48 ( 5 )   E35 - E38   2019.5

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  • Zinc Acetate Inhibits Hepatitis A Virus Replication: Possible Treatment for Patients with Type A Acute-on-Chronic Liver Failure International journal

    Tatsuo Kanda, Reina Sasaki-Tanaka, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Kazunao Hayashi, Hiroteru Kamimura, Atsunori Tsuchiya, Ryota Masuzaki, Hirofumi Kogure, Hiroaki Okamoto, Shuji Terai

    Pathogens   14 ( 9 )   2025.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    Hepatitis A virus (HAV) infection sometimes results in the occurrence of acute liver failure and acute-on-chronic liver failure (ACLF), which is often fatal, especially in patients with diabetes mellitus or elderly individuals. ACLF is observed in patients with cirrhosis who occasionally have zinc deficiency. However, effective drugs for hepatitis A are currently unavailable. Glucose-regulated protein 78 (GRP78) is an antiviral agent that has been reported to prevent HAV replication. The effects of zinc acetate on HAV HA11-1299 genotype IIIA replication and changes in GRP78 levels in human hepatocytes with or without HAV infection were examined. Zinc acetate inhibited HAV HA11-1299 genotype IIIA replication in both Huh7 and GL37 cells. Zinc acetate also inhibited HAV replication in both low- and high-glucose media. Zinc acetate increased the expression of GRP78, in response to HAV replication. The combination of zinc acetate with ribavirin led to greater suppression of both HAV HA11-1299 genotype IIIA and HAV HM175/18f genotype IB replication in Huh7 cells than that of ribavirin alone. In conclusion, zinc acetate inhibits HAV replication in accompany with the elevation of GRP78 expression without causing cellular toxicity. Zinc compounds may be useful for the treatment of ACLF caused by HAV infection.

    DOI： 10.3390/pathogens14090882

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  • Hepatitis A and E Viruses Are Important Agents of Acute Severe Hepatitis in Asia: A Narrative Review International journal

    Reina Sasaki-Tanaka, Tatsuo Kanda, Takeshi Yokoo, Hiroyuki Abe, Kazunao Hayashi, Akira Sakamaki, Hiroteru Kamimura, Shuji Terai

    Pathogens   14 ( 5 )   2025.5

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    Acute-on-chronic liver failure (ACLF) and acute liver failure (ALF) are severe hepatitis that occur in patients with and without chronic liver diseases and/or cirrhosis, respectively, and both often result in death. Hepatitis A virus (HAV) and hepatitis E virus (HEV) infection can cause these severe conditions. We reviewed the role of HAV and HEV, which infect humans through the fecal-oral route, in ALF and ACLF in Asian countries. This narrative review was the derived from a traditional non-systematic review. Hepatitis A should be recognized as one of the sexually transmitted infections, especially among men who have sex with men. HAV genotype IIIA infection seems to present a more severe clinical manifestation. Acute HEV-1 infection is associated with ALF in pregnant women in India. HEV-4, rather than HEV-3, was found in severe hepatitis in Japan. HEV also plays a role as a cause of acute insult and/or chronic liver disease in immunocompromised patients with ACLF. Further studies are needed for the development of vaccines and antivirals against HAV and HEV infections. Despite the limitations of the recording of cases and the extent of specific vaccinations, multidisciplinary cooperation, involving hepatologists, virologists, experts in public health, etc., may improve the treatment of HAV and HEV infection.

    DOI： 10.3390/pathogens14050454

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  • Polygenic Risk Score for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis: A Narrative Review International journal

    Tatsuo Kanda, Reina Sasaki-Tanaka, Hiroyuki Abe, Naruhiro Kimura, Tomoaki Yoshida, Kazunao Hayashi, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, Kenya Kamimura, Shuji Terai

    International Journal of Molecular Sciences   26 ( 11 )   2025.5

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    Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are spreading worldwide as the most critical causes of cirrhosis and hepatocellular carcinoma (HCC). Thus, improving the screening and managing strategies for patients with MASLD or MASH is necessary. A traditional non-systemic review provided this narrative. Genetic variations associated with the development of MASLD and MASH, such as PNPLA3, TM6SF2, GCKR, MBOAT7, MERTK, and HSD17B13, were initially reviewed. PNPLA3 genetic variants appeared to be strongly associated with the increased pathogenesis of MASLD, MASH, cirrhosis, and HCC. We also reviewed the useful polygenic risk score (PRS) for the development of MASLD, MASH, their related cirrhosis, and the occurrence of HCC. PRSs appeared to be better predictors of MASLD, MASH, the development of cirrhosis, and the occurrence of HCC in patients with MASLD or MASH than any single-nucleotide polymorphisms. RNA interference and antisense nucleotides against the genetic variations of PNPLA3 and HSD17B13 are also being developed. Multidisciplinary collaboration and cooperation involving hepatologists, geneticists, pharmacologists, and pathologists should resolve complicated problems in MASLD and MASH. This narrative review highlights the importance of the genetic susceptibility and PRS as predictive markers and personalized medicine for patients with MASLD or MASH in the future.

    DOI： 10.3390/ijms26115164

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  • Cholestasis in hepatitis E virus infection. International journal

    Tatsuo Kanda, Reina Sasaki-Tanaka, Takeshi Yokoo, Kazunao Hayashi, Hiroteru Kamimura, Atsunori Tsuchiya, Shuji Terai

    World journal of hepatology   17 ( 4 )   99899 - 99899   2025.4

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    Hepatitis E virus (HEV) infection causes acute hepatitis, chronic hepatitis, particularly in compromised hosts, and various extrahepatic manifestations. HEV infection is reportedly associated with biliary-pancreatic diseases, such as gallstones, cholangitis, choledocholithiasis, and acute pancreatitis. Severe jaundice and prolonged cholestasis are also atypical manifestations of HEV infection. The mechanism and genes involved in cholestasis, namely sinusoidal uptake of blood, bile salt synthesis and secretion from hepatocytes to the canaliculus, have been elucidated. HEV infection triggers severe jaundice and prolonged cholestasis in patients with genetic variants in adenosine triphosphatase phospholipid transporting 8B1, adenosine triphosphate-binding cassette (ABC) protein B4, ABCB11, Myosin VB, and/or farnesoid X receptor (FXR/NR1H4). Although prolonged cholestasis associated with these gene mutations does not seem to be specific to HEV infection, these mutations may be risk factors related to the severity of HEV infection. The use of the pregnane X receptor agonist rifampicin and the peroxisome proliferator-activated receptor activator bezafibrate may be useful for the treatment of cholestasis. These studies provide new insights into understanding the mechanisms of severe jaundice and prolonged cholestasis caused by HEV infection.

    DOI： 10.4254/wjh.v17.i4.99899

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  • Safety of edoxaban for delayed bleeding in gastrointestinal endoscopic procedures with a high risk of bleeding. International journal

    Ken-Ichi Mizuno, Junji Yokoyama, Osamu Shibata, Yuichi Kojima, Yuzo Kawata, Kazuya Takahashi, Kentaro Tominaga, Igarashi Satoshi, Hayashi Kazunao, Shuji Terai

    DEN open   5 ( 1 )   e70018   2025.4

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    OBJECTIVES: There are limited reports on the safety of gastrointestinal endoscopic procedures in individuals taking edoxaban, one of the direct oral anticoagulants. We clarified the incidence of delayed bleeding in patients who were on edoxaban in the perioperative period of gastrointestinal endoscopic procedures with a high risk of bleeding. METHODS: This was an investigator-initiated, single-center, open-label, prospective, single-arm study. Patients on warfarin or edoxaban undergoing endoscopy with a high risk of bleeding were enrolled from June 2018 to September 2021. Warfarin was replaced with edoxaban in patients on warfarin. Patients taking other direct oral anticoagulants, and antiplatelet drugs, were excluded. The primary endpoint was severe delayed bleeding (Common Terminology Criteria for Adverse Events [CTCAE] grades III-V) and the secondary endpoints included thromboembolism, all adverse events, any delayed bleeding (CTCAE grades I or II), and hospital stay durations. RESULTS: Twenty-one patients on edoxaban underwent high-risk endoscopy. Three cases (14%) experienced CTCAE grade III delayed bleeding, requiring endoscopic hemostasis. No CTCAE grade I-II delayed bleeding or thromboembolic events occurred. Cholangitis and aspiration pneumonia (conservatively treated) occurred during the hospital stay. The median length of hospital stay was 8 days (range 3-24 days). Patients with delayed bleeding had higher systolic blood pressure at admission and longer hospital stays. CONCLUSIONS: The delayed bleeding incidence in high-risk endoscopic procedures for patients on edoxaban was acceptable. Higher blood pressure may be associated with increased risk, but further research is needed.

    DOI： 10.1002/deo2.70018

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  • Coexistence of Relapsing Polychondritis, Crohn's Disease, and Pyoderma Gangrenosum Treated Successfully with Adalimumab: A Case Report and Literature Review.

    Shun Yamazaki, Kentaro Tominaga, Kotaro Watanabe, Makoto Watanabe, Shuhei Kondo, Norihiro Sakai, Tomoaki Yoshida, Yuichi Kojima, Yusuke Watanabe, Yuzo Kawata, Naruhiro Kimura, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Hiroteru Kamimura, Kazunao Hayashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   64 ( 20 )   2971 - 2978   2025.3

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    Relapsing polychondritis (RP) is a rare, progressive, immune-mediated systemic inflammatory disease of unknown etiology characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with autoimmune disease. However, co-occurrence of RP and Crohn's disease (CD) has rarely been reported. We herein report a case of coexisting RP, CD, and pyoderma gangrenosum that was successfully treated with adalimumab in combination with methotrexate. We believe that this case and literature review will facilitate the accurate and prompt diagnosis and treatment of RP combined with CD and various other complications.

    DOI： 10.2169/internalmedicine.5024-24

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  • Extremely Rare Isolated Small-Intestinal Polyp Diagnosed by Double-Balloon Endoscopy in an Asymptomatic Adult Patient. International journal

    Kentaro Tominaga, Annenkov Alexey, Yuto Tanaka, Osamu Shibata, Yuichi Kojima, Yuzo Kawata, Nao Nakajima, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Shuji Terai

    Clinical case reports   13 ( 3 )   e70255   2025.3

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    We present the first reported case of an isolated small-bowel intestinal juvenile polyp in an adult. This case is particularly noteworthy as it was asymptomatic, detected via computed tomography, localized by capsule endoscopy, and successfully resected via double-balloon endoscopy before the development of acute symptoms.

    DOI： 10.1002/ccr3.70255

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  • Pruritus in Chronic Cholestatic Liver Diseases, Especially in Primary Biliary Cholangitis: A Narrative Review International journal

    Tatsuo Kanda, Reina Sasaki-Tanaka, Naruhiro Kimura, Hiroyuki Abe, Tomoaki Yoshida, Kazunao Hayashi, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, Kenya Kamimura, Shuji Terai

    International Journal of Molecular Sciences   26 ( 5 )   2025.2

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    Patients with chronic cholestatic liver diseases often experience itch and struggle with this symptom. We discuss the mechanism of itch in patients with chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and others, and their therapies, including ileal bile acid transporter (IBAT) inhibitors. In patients with PBC, there are high serum/plasma concentrations of multiple factors, including bile salts, bilirubin, endogenous opioids, lysophosphatidic acid (LPA), autotaxin, and histamine. Bile salts, bilirubin, LPA, and autotaxin affect itch mediators in the skin and sensory nerves, while the endogenous opioid balance affects mediators in the spinal cord. Itch is sensitized by both the peripheral and central nervous systems. Both mechanisms are involved in itch in patients with chronic cholestatic liver disease. Although IBAT inhibitors have been approved for use in pediatric cholestatic conditions, such as progressive familial intrahepatic cholestasis and Alagille syndrome, IBAT inhibition seems to be a promising treatment for chronic refractory itch in patients with PBC. A traditional non-systematic review results in this narrative review. Multidisciplinary cooperation, involving hepatologists, dermatologists, and pharmacists, could provide better treatment for PBC patients suffering from refractory itch. In conclusion, we summarized the existing knowledge on itch caused by chronic cholestatic liver diseases, especially in PBC with a focus on the mechanisms and therapies. This narrative review provides the mechanisms and therapeutic options for itch in patients with chronic cholestatic liver diseases.

    DOI： 10.3390/ijms26051883

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  • A rare cause of esophageal stenosis: Compression due to a thoracic osteophyte. International journal

    Suguru Miida, Yoshihisa Arao, Nobutaka Takeda, Shu Goto, Yuichi Kojima, Naruhiro Kimura, Kazunao Hayashi, Atsunori Tsuchiya, Shuji Terai

    DEN open   4 ( 1 )   e260   2024.4

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    Several cases of esophageal stenosis caused by cervical vertebral osteophytes have been reported; however, few reports of esophageal stenosis caused by thoracic osteophytes are available. We describe the case of an 86-year-old man with esophageal stenosis caused by a thoracic osteophyte near the tracheal bifurcation. An endoscopic ultrasonography examination was scheduled to determine the cause of acute pancreatitis; however, lacerations observed at the bifurcation following endoscope removal during prior esophagogastroduodenoscopy led us to cancel the ultrasonography to avoid potential esophageal perforation. A review of the present case and six similar previous cases of thoracic osteophyte-associated esophageal stenosis (identified via a systematic search of the PubMed database) demonstrated the clinical importance of a thoracic osteophyte near physiological esophageal stenosis. Esophagogastroduodenoscopy and computed tomography should be performed to screen for vertebral osteophytes before endoscopic ultrasonography, endoscopic retrograde cholangiopancreatography, and transesophageal echocardiography to avoid iatrogenic accidents.

    DOI： 10.1002/deo2.260

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  • Solid pseudopapillary neoplasm in a woman presenting with acute pancreatitis: a case report and review of literature.

    Soichi Ishii, Hiroyuki Abe, Saori Endo, Shuhei Kondo, Nao Nakajima, Kazunao Hayashi, Akira Sakamaki, Takashi Kobayashi, Hajime Umezu, Shuji Terai

    Clinical journal of gastroenterology   16 ( 6 )   937 - 941   2023.12

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    Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor that typically affects young women in the body and tail of the pancreas. SPN is often asymptomatic in the early stages, so it is initially discovered as a large tumor. In this report, we experienced a case of a relatively small SPN discovered in the setting of acute pancreatitis. Because there have been few reports of SPN being discovered in the situation like our case, we report this case based on a review of the literature.

    DOI： 10.1007/s12328-023-01850-6

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  • Similarity of oncogenic protein expression in KRASG12D gene delivery-based rat pancreatic cancer model to that of human pancreatic cancer. International journal

    Yuto Tanaka, Kenya Kamimura, Osamu Shibata, Kohei Ogawa, Chiyumi Oda, Hiroyuki Abe, Satoshi Ikarashi, Kazunao Hayashi, Takeshi Yokoo, Toshifumi Wakai, Shuji Terai

    Biochemical and biophysical research communications   673   29 - 35   2023.9

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    BACKGROUND: The development of effective therapies and biomarkers for pancreatic cancer is an unmet clinical need. To address this, we have developed an easy-to-use pancreatic cancer rat animal model via pancreas-targeted hydrodynamic gene delivery of human pancreatic cancer-related genes. Our study aimed to determine the molecular similarity between the pancreatic tumor in the rat model and human pancreatic cancer. METHODS: KRASG12D gene-expressing plasmid was delivered to the pancreas of wild type rats via pancreas-targeted hydrodynamic gene delivery as previously reported. Tissue samples were collected at 5 weeks after the first gene delivery. The tumors developed in the rats were assessed for the expression of oncogenic proteins that are involved in human pancreatic cancer development. RESULTS: The development of a tumor mimicking pancreatic ductal adenocarcinoma was confirmed. The expression levels of Cyclin D1, c-Jun, IL-33, and Zip4 proteins in the tumor were immunohistochemically assessed and the correlation of the proteins was confirmed. The expression pattern showed similarity to that of surgically resected human pancreatic cancer tissues. CONCLUSIONS: Our study findings showing a similar pattern of oncogenic protein expression in novel KRASG12D gene-induced rat pancreatic cancer model and human pancreatic cancer will be useful for establishing novel tumor markers and therapeutic options for pancreatic cancer.

    DOI： 10.1016/j.bbrc.2023.06.057

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  • Machine learning prediction model for treatment responders in patients with primary biliary cholangitis. International journal

    Naruhiro Kimura, Kazuya Takahashi, Toru Setsu, Shu Goto, Suguru Miida, Nobutaka Takeda, Yuichi Kojima, Yoshihisa Arao, Kazunao Hayashi, Norihiro Sakai, Yusuke Watanabe, Hiroyuki Abe, Hiroteru Kamimura, Akira Sakamaki, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   7 ( 6 )   431 - 438   2023.6

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    BACKGROUND AND AIM: Treatment response to ursodeoxycholic acid may predict the prognosis of patients with primary biliary cholangitis (PBC). Recent studies have suggested the benefits of using machine learning (ML) to forecast complex medical predictions. We aimed to predict treatment response in patients with PBC using ML and pretreatment data. METHODS: We conducted a single-center retrospective study and collected data from 194 patients with PBC who were followed up for at least 12 months after treatment initiation. Patient data were analyzed with five ML models, namely random forest, extreme gradient boosting (XGB), decision tree, naïve Bayes, or logistic regression, to predict treatment response using the Paris II criteria. The established models were assessed using an out-of-sample validation. The area under the curve (AUC) was used to evaluate the efficacy of each algorithm. Overall survival and liver-related deaths were analyzed using Kaplan-Meier analysis. RESULTS: Compared to logistic regression (AUC = 0.595, P = 0.0219, 0.031 models), ML analyses showed significantly high AUC in the random forest (AUC = 0.84) and XGB (AUC = 0.83) models; however, the AUC was not significantly high for decision tree (AUC = 0.633) or naïve Bayes (AUC = 0.584) models. Kaplan-Meier analysis showed significantly improved prognoses in patients predicted to achieve the Paris II criteria by XGB (log-rank = 0.005 and 0.007). CONCLUSION: ML algorithms could improve treatment response prediction using pretreatment data, which could lead to better prognoses. In addition, the ML model using XGB could predict the prognosis of patients before treatment initiation.

    DOI： 10.1002/jgh3.12915

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  • Edwardsiella tardaによる大量膿瘍をきたした肝硬変患者の1例 症例報告(Massive empyema with Edwardsiella tarda in a patient with liver cirrhosis: a case report)

    水戸 將貴, 木村 成宏, 山崎 華子, 神保 遼, 小島 雄一, 荒生 祥尚, 林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   71回・93回   47 - 47   2022.12

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  • Two rare pancreatic parenchymal hemorrhagic lesions associated with acute pancreatitis in acute liver failure: a case report and literature review.

    Ryo Jimbo, Yoshihisa Arao, Atsunori Tsuchiya, Hanako Yamazaki, Masaki Mito, Yuichi Kojima, Yuji Kobayashi, Naruhiro Kimura, Kazunao Hayashi, Shuji Terai

    Clinical journal of gastroenterology   16 ( 2 )   254 - 262   2022.11

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    Acute pancreatitis is an uncommon occurrence in acute liver failure. Furthermore, such cases are rarely complicated by parenchymal hemorrhages. Herein, we report the case of a 69-year-old male patient with multiple pancreatic parenchymal hemorrhages concomitant with acute liver failure. The patient underwent conservative treatment for acute liver failure caused by hepatitis B virus infection. Plain computed tomography on the 30th day revealed two high-density mass lesions in the pancreatic body and tail, which were suspected to be multiple pancreatic parenchymal hemorrhages. Despite restarting gabexate mesylate, the patient died of multiple organ failure on the 49th day. The clinical information of the present case and our literature review of 61 similar cases in 43 case reports identified via a systematic keyword search of the PubMed database, which described acute pancreatitis concomitant with acute hepatitis and acute liver failure, will aid physicians in the diagnosis and treatment of this rare condition.

    DOI： 10.1007/s12328-022-01738-x

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  • Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method. International journal

    Osamu Shibata, Kenya Kamimura, Yuto Tanaka, Kohei Ogawa, Takashi Owaki, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Hiroyuki Abe, Satoshi Ikarashi, Kazunao Hayashi, Takeshi Yokoo, Shuji Terai

    Molecular therapy. Nucleic acids   28   342 - 352   2022.6

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    This research developed an easy-to-use, reproducible pancreatic cancer animal model utilizing pancreas-targeted hydrodynamic gene delivery to deliver human pancreatic cancer-related genes to the pancreas of wild-type rats. KRAS G12D -induced pancreatic intraepithelial neoplasia lesions showed malignant transformation in the main pancreatic duct at 4 weeks and developed acinar-to-ductal metaplasia, which led to pancreatic ductal adenocarcinoma within 5 weeks, and the gene combination of KRAS G12D and YAP enhanced these effects. The repeat hydrodynamic gene delivery of KRAS G12D  + YAP combination at 4 weeks showed acinar-to-ductal metaplasia in all rats and pancreatic ductal adenocarcinoma in 80% of rats 1 week later. Metastatic tumors in the liver, lymph nodes, and subcutaneous lesions and nervous invasion were confirmed. KRAS G12D and YAP combined transfer contributes to the E- to N-cadherin switch in pancreatic ductal adenocarcinoma cells and to tumor metastases. This pancreatic cancer model will speed up pancreatic cancer research for novel treatments and biomarkers for early diagnosis.

    DOI： 10.1016/j.omtn.2022.03.019

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  • 多発性出血性膵炎を伴う重度の急性肝不全の一例(A case of severe acute liver failure with multiple hemorrhagic pancreatitis)

    神保 遼, 荒生 祥尚, 山崎 華子, 水戸 將貴, 小島 雄一, 木村 成宏, 小林 雄司, 林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   70回   np41 - np41   2022.6

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  • 多発性出血性膵炎を伴う重度の急性肝不全の一例(A case of severe acute liver failure with multiple hemorrhagic pancreatitis)

    神保 遼, 荒生 祥尚, 山崎 華子, 水戸 將貴, 小島 雄一, 木村 成宏, 小林 雄司, 林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   70回   np41 - np41   2022.6

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  • 医療機関連携急性肝不全ネットワークを円滑に行い生体肝移植にて救命できた急性肝不全昏睡型の1例

    武田 信峻, 土屋 淳紀, 石井 結唯, 夏井 一輝, 荒生 祥尚, 冨永 顕太郎, 林 和直, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A265 - A265   2022.4

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    Language：Japanese   Publisher：(一社)日本肝臓学会  

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  • Utility of autologous fecal microbiota transplantation and elucidation of microbiota in diversion colitis. International journal

    Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yoshida, Yuichi Kojima, Kohei Ogawa, Yuzo Kawata, Nao Nakajima, Naruhiro Kimura, Hiroyuki Abe, Toru Setsu, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Junji Yokoyama, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Toshifumi Wakai, Shuji Terai

    DEN open   2 ( 1 )   e63   2022.4

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    Objectives: Diversion colitis (DC) is an inflammatory disorder caused by interruption of the fecal stream and subsequent nutrient deficiency from luminal bacteria. The utility of fecal microbiota transplantation (FMT) for DC was recently investigated; however, the precise pathogenesis of this condition remains unclear. This study aimed to evaluate the utility of autologous FMT in DC and to determine the related changes in the intestinal microbiota. Methods: Autologous FMT was performed to reestablish the intestinal microbiota in five patients (average age, 64.6 ± 8.3 years) with DC. They underwent double-ended colostomy. We assessed the diverted colon by endoscopy and evaluated the microbiota before and after FMT using the 16S rRNA gene sequencing method. Results: All five patients had mild inflammation (ulcerative colitis endoscopic index of severity [UCEIS] 2-3) in the diverted colon based on the colonoscopic findings. Three patients presented with symptoms, such as tenesmus, mucoid stool, and bloody stool. With FMT treatment, all patients achieved endoscopic remission (UCEIS score of 0 or 1) and symptomatic improvement. We observed a significantly decreased α-diversity in DC patients compared to healthy controls. The frequency of aerobic bacteria, such as Enterobacteriaceae, in the diverted colon decreased after autologous FMT. Conclusions: This study was the first to show that the microbiota in the diverted colon was significantly affected by autologous FMT. Since interruption of the fecal stream is central to the development of DC, FMT can be considered a promising treatment.

    DOI： 10.1002/deo2.63

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  • 消化器疾患診療に必要なバイオマーカー開発のための研究 エクソソームタンパクEps8の膵癌バイオマーカーとしての検討

    林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A172 - A172   2022.3

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  • 胆管への浸潤を伴う胆管内乳頭状粘液性腺癌 1症例報告(Intraductal papillary mucinous adenocarcinoma with bile duct invasion: A case report)

    水戸 將貴, 戸田 遼, 木村 究, 小島 雄一, 小川 光平, 木村 成宏, 荒生 祥尚, 五十嵐 聡, 林 和直, 土屋 淳紀, 寺井 崇二, 加藤 卓, 味岡 洋一, 石川 博補, 滝沢 一泰, 若井 俊文

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   69回・91回   53 - 53   2021.10

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  • 胆管への浸潤を伴う胆管内乳頭状粘液性腺癌 1症例報告(Intraductal papillary mucinous adenocarcinoma with bile duct invasion: A case report)

    水戸 將貴, 戸田 遼, 木村 究, 小島 雄一, 小川 光平, 木村 成宏, 荒生 祥尚, 五十嵐 聡, 林 和直, 土屋 淳紀, 寺井 崇二, 加藤 卓, 味岡 洋一, 石川 博補, 滝沢 一泰, 若井 俊文

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   69回・91回   53 - 53   2021.10

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  • A Rare Case of Ulcerative Colitis with Severe Pneumocystis jirovecii Pneumonia and Cytomegalovirus Colitis: A Case Report and Literature Review.

    Yusuke Watanabe, Kazunao Hayashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   61 ( 3 )   339 - 344   2021.8

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    Pneumocystis jirovecii pneumonia (PJP) and cytomegalovirus (CMV) colitis are opportunistic infections that occur during immunosuppressive treatments for ulcerative colitis (UC). The prognosis of PJP and CMV colitis is very poor. We herein report a rare case of a 74-year-old UC patient with PJP and CMV colitis that was successfully treated with intensive therapy. PJP progresses rapidly, so the timing and choice of treatment are critical. Furthermore, a literature review of similar cases suggested that prophylactic therapy for opportunistic infections might be important, especially in the elderly. This case will serve as a reference for successful treatment in future cases.

    DOI： 10.2169/internalmedicine.7953-21

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  • 急性膵炎後の膵仮性嚢胞門脈瘻による広範な門脈血栓症を発症した2例

    木村 成宏, 林 和直, 土屋 淳紀, 寺井 崇二

    日本門脈圧亢進症学会雑誌   27 ( 3 )   147 - 147   2021.8

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  • Biliary Obstruction Caused by B-Cell Lymphoma Associated With IgG4-Related Disease. International journal

    Kazuya Ogawa, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Shuji Terai

    The American journal of gastroenterology   116 ( 11 )   2166 - 2166   2021.7

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    DOI： 10.14309/ajg.0000000000001367

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  • Rapid decline in visceral adipose tissue over 1 month is associated with poor prognosis in patients with unresectable pancreatic cancer. International journal

    Oki Nakano, Hirokazu Kawai, Takamasa Kobayashi, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    Cancer medicine   10 ( 13 )   4291 - 4301   2021.7

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    BACKGROUND: Involuntary weight loss related to cachexia is common in patients with advanced cancer, but the association between body composition changes and survival is still unclear in pancreatic cancer. METHODS: We retrospectively reviewed the clinical outcomes of 55 patients with advanced pancreatic cancer undergoing palliative therapy or best supportive care (BSC). The skeletal muscle index (SMI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and visceral to subcutaneous adipose tissue area ratio (VSR) were calculated based on the cross-sectional area on two sets of computed tomography images obtained at cancer diagnosis and 1 month later before treatment. The prognostic value of body composition indexes at diagnosis and the changes in those indexes over 1 month was then evaluated. RESULTS: In total, 45 patients (81.8%) received chemotherapy, chemoradiation, or radiation therapy, whereas the remaining patients underwent BSC. There were 27 patients (49.1%) who had low SMI at cancer diagnosis. Univariate analysis showed no significant associations between the baseline body composition indexes including SMI, VATI, SATI, and VSR and survival. Meanwhile, male sex (HR, 2.79; 95% CI, 1.16-6.71, p = 0.022) and higher decrease in VATI over 1 month (HR, 2.41; 95% CI, 1.13-5.13, p = 0.023) were identified as independent risk factors for mortality in multivariate analysis. CONCLUSION: Rapid decline in VAT over 1 month is closely associated with poorer survival in unresectable advanced pancreatic cancer. A short-term assessment of body composition changes may be a rational approach to predict prognosis in these patients.

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  • 被包化膵壊死への真菌感染による敗血症性ショックをきたした一例

    山田 麻理奈[大越], 上村 顕也, 石川 夏生, 小関 洋平, 田中 裕登, 水澤 健, 佐藤 裕樹, 五十嵐 聡, 林 和直, 坂牧 僚, 横山 純二, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   37 ( 1 )   30 - 30   2021.7

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  • 感染性被包化と壊死門脈瘻を伴う膵仮性嚢胞の一例(A case of pancreatic pseudocyst-portal vein fistula with infected walled off necrosis)

    前田 悠一郎, 林 和直, 戸田 遼, 若林 拓哉, 木村 究, 水戸 將貴, 小島 雄一, 小川 光平, 荒生 祥尚, 木村 成宏, 五十嵐 聡, 土屋 淳紀, 徳永 麻美, 佐藤 知巳, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   68回   35 - 35   2021.6

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  • Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis. International journal

    Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yosida, Yuzo Kawata, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Junji Yokoyama, Toshifumi Wakai, Shuji Terai

    Biochemistry and biophysics reports   25   100892 - 100892   2021.3

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    It is reported that an increase in aerobic bacteria, a lack of short-chain fatty acids (SCFAs), and immune disorders in the diverted colon are major causes of diversion colitis. However, the precise pathogenesis of this condition remains unclear. The aim of the present study was to examine the microbiota, intestinal SCFAs, and immunoglobulin A (IgA) in the diverted colon. Eight patients underwent operative procedures for colostomies. We assessed the diverted colon using endoscopy and obtained intestinal samples from the diverted colon and oral colon in these patients. We analyzed the microbiota and SCFAs of the intestinal samples. The bacterial communities were investigated using a 16S rRNA gene sequencing method. The microbiota demonstrated a change in the proportion of some species, especially Lactobacillus, which significantly decreased in the diverted colon at the genus level. We also showed that intestinal SCFA values were significantly decreased in the diverted colon. Furthermore, intestinal IgA levels were significantly increased in the diverted colon. This study was the first to show that intestinal SCFAs were significantly decreased and intestinal IgA was significantly increased in the diverted colon. Our data suggest that SCFAs affect the microbiota and may play an immunological role in diversion colitis.

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  • 消化器領域におけるバイオマーカーの新展開 エクソソームタンパクEps8の膵癌バイオマーカーとしての検討

    林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A151 - A151   2021.3

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  • Rare paraneoplastic syndromes in digestive systems caused by lung cancer. International journal

    Hiroteru Kamimura, Tomohiro Iwasaki, Kazunao Hayashi, Shuji Terai

    BMJ case reports   14 ( 2 )   2021.2

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    We observed a rare case of two different digestive paraneoplastic syndromes that improved with the treatment of the neoplasms. The first syndrome was chronic intestinal pseudo-obstruction (CIPO), which is a subtype of paraneoplastic syndromes called a paraneoplastic neurological syndrome (PNS). The second was Stauffer's syndrome, which is a unique paraneoplastic syndrome characterised by non-metastatic intrahepatic cholestasis associated with neoplasms. Here, we report the case of a 55-year-old man who presented with two concurrent paraneoplastic syndromes in the digestive system. The intestinal pseudo-obstruction and elevated biliary enzyme levels improved as the lung cancer responded to chemotherapy. In this case, CIPO as a PNS led to the detection of lung cancer. To our knowledge, this is the first report of Stauffer's syndrome caused by lung adenocarcinoma.

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  • Immunoglobulin therapy for successful management of prolonged, recurrent jaundice in a young adult male with combined immunodeficiency

    Chiyumi Oda, Atsunori Tsuchiya, Atsushi Kimura, Kentaro Tominaga, Kazunao Hayashi, Takashi Ushiki, Hajime Umezu, Shuji Terai

    CLINICAL JOURNAL OF GASTROENTEROLOGY   14 ( 4 )   1197 - 1201   2021.2

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    DOI： 10.1007/s12328-021-01347-0

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  • Visceral Adipose Tissue Index and Hepatocellular Carcinoma Are Independent Predictors of Outcome in Patients with Cirrhosis Having Endoscopic Treatment for Esophageal Varices Reviewed International journal

    Naruhiro Kimura, Atsunori Tsuchiya, Chiyumi Oda, Atsushi Kimura, Kazunori Hosaka, Kentaro Tominaga, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    DIGESTIVE DISEASES   39 ( 1 )   58 - 65   2021.1

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  • Comparison of Oral and Esophageal Microbiota in Patients with Achalasia Before and After Peroral Endoscopic Myotomy. International journal

    Kazuya Takahashi, Hiroki Sato, Takeshi Mizusawa, Kentaro Tominaga, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology   32 ( 1 )   42 - 52   2021.1

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    BACKGROUND/AIMS: Patients with achalasia have a high incidence of esophageal squamous cell carcinoma (ESCC), which may be associated with alterations in oral and esophageal microbiota caused by food stasis. This study compared the oral and esophageal microbiota of patients with achalasia before and after peroral endoscopic myotomy (POEM). It also compared patients with achalasia to those with ESCC. MATERIALS AND METHODS: The study prospectively examined 6 patients with achalasia and 14 with superficial ESCC. Oral samples obtained from the buccal mucosa using a swab and esophageal samples obtained from the mid-esophagus using a brush via endoscopy were analyzed by 16S rRNA metagenome sequencing. Additionally, endoscopic and histological findings of patients with achalasia before and after POEM were prospectively compared. RESULTS: In patients with achalasia, Streptococcus was most abundant in both the oral and the esophageal microbiota, and these microbiota were significantly different. Although the overall structure of the oral and esophageal microbiota did not change after POEM, the relative abundance rate of Haemophilus and Neisseria increased in the esophagus, and endoscopic findings of inflammation improved after POEM (P = .04). The relative abundance of microbiota was not different among patients with achalasia from those with ESCC. CONCLUSIONS: The oral and esophageal microbiota were significantly different in patients with achalasia, and some of the composition of the esophageal microbiota changed after POEM. However, these findings and disease-specific microbiota should be further evaluated in large-scale studies.

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  • Novel Strategy for Diagnosis of Focal Nodular Hyperplasia Using Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid: Enhanced Magnetic Resonance Imaging and Magnetic Resonance Elastography International journal

    Nobutaka Takeda, Atsunori Tsuchiya, Kazuki Natsui, Yui Ishii, Yoshihisa Arao, Naruhiro Kimura, Kentaro Tominaga, Suguru Takeuchi, Kazunao Hayashi, Masaaki Takamura, Shuji Terai

    CASE REPORTS IN GASTROENTEROLOGY   15 ( 2 )   507 - 512   2021

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  • Choledochocele observed on direct peroral cholangioscopy using an ultra-slim endoscope

    Satoshi Ikarashi, Kazunao Hayashi, Shuji Terai

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   28 ( 11 )   e49-e51   2020.12

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    DOI： 10.1002/jhbp.884

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  • Risk factors for walled-off necrosis associated with severe acute pancreatitis: A multicenter retrospective observational study Reviewed

    Satoshi Ikarashi, Hirokazu Kawai, Kazunao Hayashi, Junji Kohisa, Toshifumi Sato, Yujiro Nozawa, Shinichi Morita, Hiromitsu Oka, Munehiro Sato, Yukio Aruga, Seiichi Yoshikawa, Shuji Terai

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   27 ( 11 )   887 - 895   2020.11

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  • Usefulness of ultrasonography to assess the response to steroidal therapy for the rare case of type 2b immunoglobulin G4-related sclerosing cholangitis without pancreatitis: A case report International journal

    Yuto Tanaka, Kenya Kamimura, Ryota Nakamura, Marina Ohkoshi-Yamada, Yohei Koseki, Takeshi Mizusawa, Satoshi Ikarashi, Kazunao Hayashi, Hiroki Sato, Akira Sakamaki, Junji Yokoyama, Shuji Terai

    WORLD JOURNAL OF CLINICAL CASES   8 ( 22 )   5821 - 5830   2020.11

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    DOI： 10.12998/wjcc.v8.i22.5821

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  • Effectiveness of Endoscopic Pancreatic Stenting for Pancreatic Pseudocyst-Portal Vein Fistula International journal

    Atsushi Kimura, Kazunao Hayashi, Chiyumi Oda, Kazunori Hosaka, Naruhiro Kimura, Kentaro Tominaga, Satoshi Ikarashi, Atsunori Tsuchiya, Shuji Terai

    CASE REPORTS IN GASTROENTEROLOGY   14 ( 3 )   570 - 576   2020.9

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  • Rare case of circumferential esophageal peeling Reviewed International journal

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Yui Ishii, Nobutaka Takeda, Kazuki Natsui, Yuzo Kawata, Naruhiro Kimura, Yoshihisa Arao, Suguru Takeuchi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    CLINICAL CASE REPORTS   8 ( 7 )   1306 - 1308   2020.7

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    DOI： 10.1002/ccr3.2846

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  • Change in body composition in patients with achalasia before and after peroral endoscopic myotomy Reviewed International journal

    Takeshi Mizusawa, Hiroki Sato, Kenya Kamimura, Satoru Hashimoto, Ken-Ichi Mizuno, Hiroteru Kamimura, Satoshi Ikarashi, Kazunao Hayashi, Masaaki Takamura, Junji Yokoyama, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   35 ( 4 )   601 - 608   2020.4

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  • Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016

    Atsushi Masamune, Kazuhiro Kikuta, Shin Hamada, Ichiro Tsuji, Yoshifumi Takeyama, Tooru Shimosegawa, Kazuichi Okazaki, Atsushi Kanno, Takanori Sano, Kazushige Uchida, Tsukasa Ikeura, Nao Fujimori, Yousuke Nakai, Terumi Kamisawa, Kensuke Kubota, Masayo Motoya, Kyoko Shimizu, Tomoyuki Ushijima, Mitsuharu Fukasawa, Itaru Naitoh, Masayuki Ueno, Kosuke Okuwaki, Norimitsu Uza, Masanori Asada, Tsuyoshi Mukai, Yasushi Kudo, Kota Uetsuki, Akira Mitoro, Hiroyuki Watanabe, Shuji Terai, Kazunao Hayashi, Yoshiki Imamura, Shin Haba, Kazuo Hara, Toshio Fujisawa, Eisuke Iwasaki, Fumihiro Okumura, Yuki Kawaji, Masayuki Kitano, Takayoshi Nishino, Masatsugu Nagahama, Atsuyuki Hirano, Yukio Aruga, Satoshi Yamamoto, Kazuo Inui, Yoshimasa Kubota, Kuniyuki Takahashi, Junichi Sakagami, Takashi Kobayashi, Takashi Miraki, Takayuki Watanabe, Hiroko Sato, Yasuto Takeda, Masahiro Satoh, Kasen Kobashigawa, Mitsuru Chiba, Tetsuo Tamura, Naoya Sawada, Kazuhiro Mizukami, Masanari Sekine, Jun Unno, Tetsuya Ishizawa, Hiroyuki Funayama, Katsuko Hatayama, Hiroyuki Miyakawa, Toshitaka Sakai, Masaki Kuwatani, Masao Toki, Tatsuya Toyokawa, Shinichi Hashimoto, Takao Itoi, Yuji Iwashita, Ai Sato, Hironari Kato, Hajime Takatori, Yusuke Iizawa, Takuji Iwashita, Hiromu Kondo, Yuichirou Sato, Minoru Tanabe, Toshiro Ogura, Katsutoshi Yamamoto, Tomohiro Masaka, Morimichi Setsuda, Tatsushi Sano, Saburo Matsubara, Katsuya Kitamura, Keisuke Iwata, Nakao Shirahata, Hideki Hagiwara, Motoyuki Yoshida, Tomoyuki Yokota, Hiroaki Shigoka, Naoya Kaneko, Makoto Abue, Nanae Tsuruoka

    JOURNAL OF GASTROENTEROLOGY   55 ( 4 )   462 - 470   2020.4

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  • Rare Brain Metastasis From a Pancreatobiliary Subtype of Intraductal Papillary Mucinous Neoplasm Reviewed International journal

    Yoshihisa Arao, Kenya Kamimura, Masatoshi Ikemi, Kazunao Hayashi, Masayuki Takaki, Shunsaku Takahashi, Satoshi Seino, Hiroyuki Abe, Shintaro Tsuboguchi, Yutaka Otsu, Kazuhiro Sanpei, Junji Kohisa, Shuhei Kondo, Yusuke Tani, Junko Ito, Yasuko Toyoshima, Akiyoshi Kakita, Yoichi Ajioka, Shuji Terai

    PANCREAS   49 ( 1 )   E8 - E11   2020.1

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  • Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review Reviewed

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Takeshi Mizusawa, Shinichi Morita, Yui Ishii, Nobutaka Takeda, Kazuki Natsui, Yuzo Kawata, Naruhiro Kimura, Yoshihisa Arao, Kazuya Takahashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    INTERNAL MEDICINE   59 ( 16 )   1983 - 1989   2020

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  • Pancreas Gas Gangrene Caused by Klebsiella pneumoniae Reviewed

    Yui Ishii, Atsunori Tsuchiya, Kazunao Hayashi, Shuji Terai

    INTERNAL MEDICINE   59 ( 22 )   2963 - 2964   2020

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    DOI： 10.2169/internalmedicine.5257-20

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  • Portal Vein Thrombosis Associated with Trousseau Syndrome due to Urinary Bladder Squamous Cell Carcinoma in a Liver Cirrhosis Patient Reviewed

    Naruhiro Kimura, Atsunori Tsuchiya, Chiyumi Oda, Atsushi Kimura, Kazunori Hosaka, Kentaro Tominaga, Kazunao Hayashi, Tatsuya Abe, Hajime Umezu, Shuji Terai

    INTERNAL MEDICINE   59 ( 16 )   1971 - 1975   2020

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    DOI： 10.2169/internalmedicine.4112-19

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  • Wavy mucosal tear in the sigmoid colon Reviewed International journal

    Kentaro Tominaga, Junji Yokoyama, Kazunao Hayashi, Atsunori Tsuchiya, Shuji Terai

    CLINICAL CASE REPORTS   7 ( 9 )   1825 - 1826   2019.9

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    DOI： 10.1002/ccr3.2275

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  • Co-existent ulcerative colitis and Guillain-Barre syndrome: a case report and literature review Reviewed

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Atsushi Kimura, Chiyumi Oda, Kazunori Hosaka, Yuzo Kawata, Naruhiro Kimura, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    CLINICAL JOURNAL OF GASTROENTEROLOGY   12 ( 3 )   243 - 246   2019.6

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    DOI： 10.1007/s12328-019-00939-1

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  • CONSIDERATION OF SERUM IGA IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

    Kentaro Tominaga, Yuzo Kawata, Naruhiro Kimura, Takeshi Mizusawa, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Kenichi Mizuno, Satoru Hashimoto, Atsunori Tsuchiya, Junji Yokoyama, Shuji Terai

    GASTROENTEROLOGY   156 ( 6 )   S847 - S847   2019.5

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  • Diverse perspectives to address for the future treatment of heterogeneous hepatocellular carcinoma Reviewed International journal

    Atsunori Tsuchiya, Masahiro Ogawa, Takayuki Watanabe, Suguru Takeuchi, Yuichi Kojima, Yusuke Watanabe, Naruhiro Kimura, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    HELIYON   5 ( 3 )   e01325   2019.3

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  • A case of inferior vena cava thrombosis caused by compression due to growing giant liver cyst Reviewed

    Naruhiro Kimura, Atsunori Tsuchiya, Masahiro Ogawa, Yusuke Watanabe, Kazunao Hayashi, Junji Yokoyama, Hajime Umezu, Shuji Terai

    CLINICAL JOURNAL OF GASTROENTEROLOGY   12 ( 1 )   71 - 75   2019.2

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    DOI： 10.1007/s12328-018-0885-x

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  • EpCAM- and/or NCAM-Expressing Hepatocellular Carcinoma in Which Behavior of Hepatic Progenitor Cell Marker-Positive Cells Are Followed. Reviewed International journal

    Tsuchiya A, Suda T, Oda C, Kimura A, Hosaka K, Kimura N, Tominaga K, Hayashi K, Takamura M, Terai S

    Case reports in gastroenterology   13 ( 1 )   118 - 124   2019.1

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  • Gastrointestinal: A case of hypereosinophilic syndrome with esophageal involvement. Reviewed

    Takahashi K, Sato H, Tominaga K, Kohisa J, Ikarashi S, Hayashi K, Miuzno K, Hashimoto S, Yokoyama J, Terai S

    Journal of gastroenterology and hepatology   33 ( 11 )   1817   2018.11

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  • Successful treatment of aortic dissection during sorafenib therapy for hepatocellular carcinoma Reviewed International journal

    Atsunori Tsuchiya, Masahiro Ogawa, Yusuke Watanabe, Naruhiro Kimura, Kazunao Hayashi, Takeshi Suda, Shuji Terai

    CLINICAL CASE REPORTS   6 ( 8 )   1643 - 1644   2018.8

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  • Management decision based on lymphovascular involvement leads to favorable outcomes after endoscopic treatment of esophageal squamous cell carcinoma Reviewed International journal

    Kazuya Takahashi, Satoru Hashimoto, Ken-ichi Mizuno, Takamasa Kobayashi, Kentaro Tominaga, Hiroki Sato, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Manabu Takeuchi, Junji Yokoyama, Hirokazu Kawai, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    ENDOSCOPY   50 ( 7 )   662 - 670   2018.7

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    DOI： 10.1055/s-0043-124433

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  • IS ENDOSCOPIC SUBMUCOSAL DISSECTION A FEASIBLE TREATMENT FOR ESOPHAGOGASTRIC JUNCTION CANCER?

    Kazuya Takahashi, Satoru Hashimoto, Kenichi Mizuno, Hiroki Sato, Kentaro Tominaga, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB396 - AB397   2018.6

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  • SAFETY AND EFFICACY OF PROPOFOL-BASED SEDATION FOR BALLOON ENTEROSCOPE-ASSISTED ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN ELDERLY PATIENTS

    Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Kazuya Takahashi, Kentaro Tominaga, Kenichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB229 - AB229   2018.6

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  • ENDOSCOPIC MANAGEMENT OF UNRESECTABLE MALIGNANT HILAR STRICTURES USING THREADED INSIDE STENTS VERSUS METALLIC STENTS

    Kazunao Hayashi, Satoshi Ikarashi, Junji Kohisa, Kazuya Takahashi, Kentaro Tominaga, Ken-ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB208 - AB208   2018.6

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  • IS ENDOSCOPIC SUBMUCOSAL DISSECTION VALUABLE FOR ELDERLY PATIENTS WITH SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA?

    Satoru Hashimoto, Kenichi Mizuno, Kazuya Takahashi, Hiroki Sato, Kentaro Tominaga, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB287 - AB287   2018.6

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  • RISK FACTORS FOR WALLED-OFF NECROSIS ASSOCIATED WITH SEVERE ACUTE PANCREATITIS: A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY

    Satoshi Ikarashi, Kazunao Hayashi, Hirokazu Kawai, Junji Kohisa, Toshifumi Sato, Yujiro Nozawa, Shinichi Morita, Hiromitsu Oka, Munehiro Sato, Yukio Aruga, Seiichi Yoshikawa, Shuji Terai

    GASTROENTEROLOGY   154 ( 6 )   S289 - S289   2018.5

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  • Ombitasvir-Paritaprevir-Ritonavir Therapy in a Kidney Transplant Recipient With Chronic Hepatitis C Virus Genotype 1 Infection: A Case Report on the Importance of Considering Drug-Drug Interactions and Monitoring Cyclosporine Levels. International journal

    S Takeuchi, M Takamura, T Yoshida, K Takahashi, K Hayashi, S Hashimoto, S Yamagiwa, M Tasaki, Y Nakagawa, K Saito, Y Tanabe, Y Tomita, S Terai

    Transplantation proceedings   50 ( 3 )   884 - 886   2018.4

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    A 74-year-old Japanese man with a history of chronic hepatitis C and kidney transplant (KT) was administered pegylated-interferon plus ribavirin therapy. However, this therapy was ineffective. The patient was then hospitalized to receive ombitasvir (OBV) plus paritaprevir (PTV) plus ritonavir (r) antiviral combination therapy. He tested negative for the virus after 4 weeks, and completed 12 weeks of treatment. The patient ultimately achieved a sustained virological response after the 12 weeks of treatment. Cyclosporine (CyA) trough levels, during the OBV-PTV-r therapy, reached a peak within 5 days of initiating therapy, and increases in serum creatinine and total bilirubin were also observed. However, onset of irreversible nephropathy and hepatopathy were avoided by reducing the CyA dosage. The OBV-PTV-r therapy demonstrated a sufficient antiviral effect and could be safely administered postoperatively to patients having undergone KT. When a combination therapy with interferon-free, direct-acting antivirals is used in patients post-transplantation, consideration of drug-drug interactions with and monitoring CyA are of vital importance.

    DOI： 10.1016/j.transproceed.2018.01.006

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  • The factors influencing long-term outcomes of stenting for malignant colorectal obstruction in elderly group in community medicine Reviewed International journal

    Michitaka Imai, Kenya Kamimura, Yoshifumi Takahashi, Toshihiro Sato, Osamu Isokawa, Masaki Maruyama, Takamasa Kobayashi, Kazunao Hayashi, Shuji Terai

    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE   33 ( 2 )   189 - 197   2018.2

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    DOI： 10.1007/s00384-017-2946-x

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  • Full-layer mucosal histology in achalasia: Histological epithelial wave is characteristic in "pinstripe pattern"-positive achalasia. Reviewed

    Sato H, Takahashi K, Nakajima N, Hasegawa G, Mizuno K, Hashimoto S, Ikarashi S, Hayashi K, Honda Y, Yokoyama J, Sato Y, Terai S

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society   30 ( 1 )   e13168 - e13168   2018.1

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/nmo.13168

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  • A Case of Pancreatic Schwannoma Diagnosed Preoperatively by Endoscopic Ultrasonography-Guided Fine Needle Aspiration and Treated with Laparoscopic Surgery. Reviewed International journal

    Kazuao Hayashi, Atsunori Tsuchiya, Satoshi Ikarashi, Kazuyasu Takizawa, Shuji Terai

    Journal of pancreatic cancer   4 ( 1 )   7 - 10   2018

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    Background: Pancreatic tumors are often difficult to diagnose in atypical cases, and a pancreatic schwannoma is very rare. We present a case of pancreatic schwannoma with calcification diagnosed preoperatively by endoscopic ultrasonography (EUS)-guided fine needle aspiration (FNA) and treated with laparoscopic distal pancreatectomy. Presentation: A 72-year-old-woman was admitted to our hospital due to a 6 × 4.5 cm large tumor in the pancreatic tail. Imaging modalities revealed that the tumor was hypovascular and gradually enhanced with calcification, but was without cystic lesions. EUS revealed the tumor had a clear boundary with a low echoic mass. EUS-FNA was performed and spindle-shaped cells that were immunopositive for S-100 and negative for c-kit, CD34, and desmin were detected, resulting in a diagnosis of schwannoma. Laparoscopic distal pancreatectomy with splenectomy was safely performed without recurrence for a year. Conclusions: Schwannoma is very rare; however, characteristics of the tumor, such as calcification, can help the diagnosis and, if possible, EUS-FNA should be performed for an appropriate treatment decision.

    DOI： 10.1089/pancan.2018.0002

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  • Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor Reviewed International journal

    Kazunao Hayashi, Kenya Kamimura, Kazunori Hosaka, Satoshi Ikarashi, Junji Kohisa, Kazuya Takahashi, Kentaro Tominaga, Kenichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Satoshi Yamagiwa, Kazuyasu Takizawa, Toshifumi Wakai, Hajime Umezu, Shuji Terai

    WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY   9 ( 12 )   583 - 589   2017.12

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    DOI： 10.4253/wjge.v9.i12.583

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  • Efficacy and Safety of Pancreas-Targeted Hydrodynamic Gene Delivery in Rats Reviewed International journal

    Kohei Ogawa, Kenya Kamimura, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Norihiro Sakai, Takuro Nagoya, Akira Sakamaki, Satoshi Abe, Kazunao Hayashi, Satoshi Ikarashi, Junji Kohisa, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   9   80 - 88   2017.12

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    DOI： 10.1016/j.omtn.2017.08.009

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  • Changes in esophageal motility after endoscopic submucosal dissection for superficial esophageal cancer: a high-resolution manometry study. Reviewed

    Takahashi K, Sato Y, Takeuchi M, Sato H, Nakajima N, Ikarashi S, Hayashi K, Mizuno KI, Honda Y, Hashimoto S, Yokoyama J, Terai S

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus   30 ( 11 )   1 - 8   2017.11

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    DOI： 10.1093/dote/dox057

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  • Development and use of a non-biomaterial model for hands-on training of endoscopic procedures Reviewed International journal

    Hiroki Sato, Ken-ichi Mizuno, Yuichi Sato, Satoru Hashimoto, Kazunao Hayashi, Satoshi Ikarashi, Yutaka Honda, Junji Yokoyama, Shuji Terai

    ANNALS OF TRANSLATIONAL MEDICINE   5 ( 8 )   182 - 182   2017.4

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    DOI： 10.21037/atm.2017.01.27

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  • Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis Reviewed International journal

    Hiroki Sato, Nao Nakajima, Kazuya Takahashi, Go Hasegawa, Ken-ichi Mizuno, Satoru Hashimoto, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   23 ( 13 )   2414 - 2423   2017.4

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    DOI： 10.3748/wjg.v23.i13.2414

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  • Loss of peristalsis of the esophagus due to diffuse esophageal leiomyomatosis Reviewed International journal

    Kazuya Takahashi, Yui Ishii, Kazunao Hayashi, Satoshi Ikarashi, Hirokazu Kawai, Yuichi Sato, Shuji Terai

    ENDOSCOPY   49 ( S 01 )   E95 - E96   2017.2

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    DOI： 10.1055/s-0043-100691

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  • Early Detection of Hepatocellular Carcinoma Recurrence Using the Highly Sensitive Fucosylated Fraction of Alpha-Fetoprotein Reviewed

    Toru Setsu, Atsunori Tsuchiya, Takayuki Watanabe, Takuro Nagoya, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

    Case Reports in Gastroenterology   11 ( 1 )   142 - 147   2017.1

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    DOI： 10.1159/000462969

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  • A Mesenteric Desmoid Tumor with Rapid Progression Reviewed

    Kazunao Hayashi, Masaaki Takamura, Hisashi Yokoyama, Yuichi Sato, Satoshi Yamagiwa, Hitoshi Nogami, Toshifumi Wakai, Go Hasegawa, Shuji Terai

    INTERNAL MEDICINE   56 ( 5 )   505 - 508   2017

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    DOI： 10.2169/internalmedicine.56.7320

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  • The Combination Therapy of Dissolution Using Carbonated Liquid and Endoscopic Procedure for Bezoars: Pragmatical and Clinical Review Reviewed International journal

    Kohei Ogawa, Kenya Kamimura, Ken-ichi Mizuno, Yoko Shinagawa, Yuji Kobayashi, Hiroyuki Abe, Yukari Watanabe, Shunsaku Takahashi, Kazunao Hayashi, Junji Yokoyama, Manabu Takeuchi, Masaaki Kobayashi, Satoshi Yamagiwa, Yuichi Sato, Shuji Terai

    GASTROENTEROLOGY RESEARCH AND PRACTICE   2016   7456242 - 7456242   2016

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    DOI： 10.1155/2016/7456242

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  • Endoscopic Removal of Ingested Dentures and Dental Instruments: A Retrospective Analysis Reviewed International journal

    Ken-ichi Mizuno, Kazuya Takahashi, Kentaro Tominaga, Yuki Nishigaki, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Takashi Yamamoto, Yutaka Honda, Satoru Hashimoto, Kenya Kamimura, Manabu Takeuchi, Junji Yokoyama, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    GASTROENTEROLOGY RESEARCH AND PRACTICE   2016   3537147 - 3537147   2016

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  • [Successful treatment with bortezomib in a patient with systemic primary AL amyloidosis manifesting severe gastrointestinal bleeding]. Reviewed

    Tori Ida, Kazunao Hayashi, Toru Ida, Satoko Hirano, Fumie Nakamura, Hirohito Sone, Masahiro Fujiwara

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 7 )   808 - 14   2014.7

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    We present a systemic primary AL amyloidosis patient with severe gastrointestinal bleeding for whom treatment with bortezomib and dexamethasone was very effective. An 83-year-old woman was admitted to our hospital suffering from multiple gastric ulcers with bleeding. She had monoclonal protein (IgG, λ) in her serum. Systemic primary AL amyloidosis was diagnosed. She was also suspected of having amyloid deposition in cardiac muscle, as well as her bladder and intestinal mucosa. However, we were unable to carry out other invasive examinations due to her bleeding tendency. She was treated with bortezomib and dexamethasone. Her bleeding tendency gradually diminished. After one year, the bleeding tendency had completely resolved. However, she still had amyloid deposition in her gastric mucosa and skin.

    DOI： 10.11406/rinketsu.55.808

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  • Giant hepatic cyst with septal structure: diagnosis and management. Reviewed International journal

    Toshihiro Sato, Michitaka Imai, Kazunao Hayashi, Osamu Isokawa, Tatsuya Nomura, Yoshiaki Tsuchiya, Takashi Kawasaki

    International journal of hepatology   2013   981975 - 981975   2013

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    The hepatic cyst is a common benign liver tumor, and no surgical treatment is necessary. However, it is difficult to correctly diagnose the giant hepatic cyst containing the solid septal structures inside, from the malignant cystadenocarcinomas. The various imaging modalities such as computed tomography, magnetic resonance imaging, and ultrasonography, have been developed and are useful for the diagnosis of these liver tumors. Reviewing the other reports in this paper, the combination of more than 2 modalities will help to diagnose these tumors; however, the malignant potential is unable to be excluded if the tumor is huge. Therefore, the surgical resection should be considered for the huge hepatic cysts with septal structures if the correct diagnosis is unable to be made. For example, when the hemorrhages cause the granulation in the septa which often shows neovascularization, the imaging modalities are unable to define this situation from the malignant tissue with hypervascularity. Therefore, with the careful review of other reports, we conclude that if the imaging studies show the possible malignant potential or the sizing-up is marked, the surgical treatment should be considered with the consent from the patients.

    DOI： 10.1155/2013/981975

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  • Primary Malignant Mesothelioma of the Appendix Reviewed

    Kazunao Hayashi, Masaaki Takamura, Yuichi Sato, Kumiko Takahashi, Hiromi Sato, Kazumi Youkou, Hisashi Yokoyama, Minoru Nomoto, Chihiro Inoue, Go Hasegawa, Yutaka Aoyagi

    INTERNAL MEDICINE   51 ( 9 )   1027 - 1030   2012

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    DOI： 10.2169/internalmedicine.51.6990

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  • Effects of Pluronics surfactants on morphology and porosity of hematite particles produced from forced hydrolysis reaction

    Kazuhiko Kandori, Kazunao Hayashi, Masaki Matsukawa, Masao Fukusumi, Yoshiaki Morisada

    COLLOID AND POLYMER SCIENCE   288 ( 10-11 )   1071 - 1079   2010.7

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    DOI： 10.1007/s00396-010-2234-6

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Research Projects

  • Pancreatic cancer biomarker research by the exosome proteome analysis of the HGD rat pancreatic cancer model

    Grant number：21K07910

    2021.4 - 2024.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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