Updated on 2025/11/13

写真a

 
KANAZAWA Masato
 
Organization
Brain Research Institute Center for Integrated Human Brain Science Department of Functional Neurology and Neurosurgery Specially Appointed Professor
Title
Specially Appointed Professor
External link

Degree

  • 医学 ( 2009.3   新潟大学 )

Research Areas

  • Life Science / Neurology

Research History

  • Niigata University   Brain Research Institute Clinical Neuroscience Branch Department of Neurology   Associate Professor

    2019.7 - 2025.3

  • Niigata University   Brain Research Institute Clinical Neuroscience Branch Department of Neurology   Lecturer

    2018.4 - 2019.6

  • Niigata University   University Medical and Dental Hospital Neurology   Assistant Professor

    2013.11 - 2018.3

  • Niigata University   University Medical and Dental Hospital Neurology   Specially Appointed Assistant Professor

    2012.6 - 2013.10

  • Niigata University   University Medical and Dental Hospital Neurology   Specially Appointed Assistant Professor

    2009.10 - 2010.3

 

Papers

  • Oxygen–glucose-deprived peripheral blood mononuclear cells act on hypoxic lesions after ischemia-reperfusion injury

    Takeshi Kanayama, Masahiro Hatakeyama, Natsuki Akiyama, Yutaka Otsu, Osamu Onodera, Takayoshi Shimohata, Masato Kanazawa

    Experimental Neurology   385   115121 - 115121   2025.3

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.expneurol.2024.115121

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  • Oxygen–Glucose Deprived Peripheral Blood Mononuclear Cells Protect Against Ischemic Stroke International journal

    Yutaka Otsu, Masahiro Hatakeyama, Takeshi Kanayama, Natsuki Akiyama, Itaru Ninomiya, Kaoru Omae, Taisuke Kato, Osamu Onodera, Masanori Fukushima, Takayoshi Shimohata, Masato Kanazawa

    Neurotherapeutics   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media {LLC}  

    DOI： 10.1007/s13311-023-01398-w

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    Other Link： https://link.springer.com/article/10.1007/s13311-023-01398-w/fulltext.html

  • Intercellular communication between peripheral monocytes and central nervous system cells in stroke Invited Reviewed

    Masato Kanazawa, Masahiro Hatakeyama

    Neural Regeneration Research   2025.10

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    Abstract

    Stroke, particularly ischemic stroke, induces dynamic interactions between peripheral monocytes and central nervous system cells, influencing neuroinflammation, repair, and functional recovery. Monocytes infiltrate the brain post-stroke and differentiate into macrophages, which interact with microglia, astrocytes, endothelial cells, and neurons. These interactions, mediated by chemokines, cytokines, and extracellular vesicles, can be detrimental or beneficial depending on context. Another interface is the gut–immune–brain axis, wherein gut microbiota, immune cells, and central nervous system-resident populations engage in reciprocal communication. Emerging therapies targeting monocyte subsets, their recruitment, and communication pathways. These include preconditioned peripheral blood mononuclear cells, bone marrow-derived mononuclear cells, mesenchymal stem cells, and cellfree or cell-mediated approaches utilizing the secretome. Together, these interventions hold promise for enhancing stroke recovery by modulating the immune–neural interface. This review summarizes recent advances in monocyte–central nervous system communication and its translational potential in stroke.

    DOI： 10.4103/nrr.nrr-d-25-00738

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  • From mechanism to classification: Understanding a novel model of cerebral small vessel disease

    Masato Kanazawa, Masahiro Hatakeyama

    Journal of Cerebral Blood Flow & Metabolism   2025.8

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/0271678X251326373

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  • Blood–brain barrier dysfunction in multiple system atrophy: A human postmortem study

    Ramil Gabdulkhaev, Hiroshi Shimizu, Masato Kanazawa, Yasuko Kuroha, Arika Hasegawa, Jiro Idezuka, Kazuki Tainaka, Osamu Onodera, Akiyoshi Kakita

    Neuropathology   2025.6

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/neup.13021

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  • Utility of Cerebrospinal Fluid Transferrin Receptor per Ferritin Ratio in Progressive Supranuclear Palsy

    Natsuki Akiyama, Masato Kanazawa, Kensaku Kasuga, Masahiro Hatakeyama, Takeshi Ikeuchi, Osamu Onodera

    Movement Disorders Clinical Practice   2025.4

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/mdc3.14313

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  • Early diagnosis of cryptococcal meningoencephalitis in HIV-negative patients: Integration of brain MRI and clinical findings

    Kosei Nakamura, Masato Kanazawa, Yuka Koike, Takuya Konno, Osamu Onodera

    eNeurologicalSci   38   100552 - 100552   2025.3

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ensci.2025.100552

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  • Frequency of anti-IgLON5 disease in patients with a typical clinical presentation of progressive supranuclear palsy/corticobasal syndrome

    Yoya Ono, Hiroshi Takigawa, Akira Takekoshi, Nobuaki Yoshikura, Ikuko Aiba, Ritsuko Hanajima, Hisanori Kowa, Masato Kanazawa, Takahiko Tokuda, Aya Midori Tokumaru, Mitsuya Morita, Kazuko Hasegawa, Kenji Nakashima, Takeshi Ikeuchi, Akio Kimura, Takayoshi Shimohata

    Parkinsonism & Related Disorders   107289 - 107289   2025.1

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.parkreldis.2025.107289

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  • Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells

    Masato Kanazawa, Itaru Ninomiya, Yutaka Otsu, Masahiro Hatakeyama

    Neural Regeneration Research   2024.11

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.4103/NRR.NRR-D-23-01784

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  • A case of isolated dystextia due to subcortical infarction: a novel condition of digital device era

    Masahiro Hatakeyama, Takeshi Kanayama, Saori Tokunaga, Toshiya Kizaki, Shintaro Tsuboguchi, Masato Kanazawa, Osamu Onodera

    BMC Neurology   24 ( 1 )   2024.10

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1186/s12883-024-03892-w

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    Other Link： https://link.springer.com/article/10.1186/s12883-024-03892-w/fulltext.html

  • Indications for a brain biopsy in neurological diseases of unknown etiology: The role of magnetic resonance imaging findings and liquid biopsy in yielding definitive pathological diagnoses. International journal

    Toshiya Kizaki, Masato Kanazawa, Takanobu Ishiguro, Manabu Natsumeda, Mari Tada, Hiroshi Shimizu, Kouichirou Okamoto, Makoto Oishi, Akiyoshi Kakita, Yukihiko Fujii, Osamu Onodera

    Journal of the neurological sciences   463   123150 - 123150   2024.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    Brain biopsies are often considered for patients who cannot be diagnosed with various laboratory test results. However, physicians tend to be hesitant regarding their application in possibly non-neoplastic brain diseases, due to the invasiveness and risks. The aim was to determine the indications for brain biopsies in cases of neurological diseases of unknown etiology. We retrospectively evaluated diagnostic accuracy, laboratory findings (including a liquid biopsy for malignant lymphoma), magnetic resonance imaging (MRI) characteristics and the post-treatment outcomes of patients undergoing brain biopsies for neurological diseases of unknown etiology. The data of patients who had undergone a brain biopsy during their admission to Niigata University Hospital, between 2011 and 2024, were reviewed. Moreover, the laboratory data and MRI findings between patients with definitive and nonspecific biopsy diagnoses were compared. Twenty-six patients underwent a brain biopsy, and a definitive diagnosis was obtained in 14 patients (53.8%). Even in cases where a nonspecific diagnosis was made, biopsy findings helped rule out malignancy and guide clinical diagnosis and treatment decisions. The liquid biopsy for malignant lymphoma was performed in eight patients, with one yielding a positive result, consistent with primary central nervous system lymphoma. The sensitivity and specificity of liquid biopsy were 0.5 and 1, respectively. Diffusely contrasted cortical lesions and the presence of mass effects on MRI, were significantly associated with a definitive diagnosis, compared to a nonspecific diagnosis. In conclusion, brain MRI and liquid biopsies can assist in determining the appropriate indications for brain biopsies in neurological diseases of unknown etiology.

    DOI： 10.1016/j.jns.2024.123150

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  • Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study. International journal

    Keita Sakurai, Aya M Tokumaru, Mari Yoshida, Yuko Saito, Koichi Wakabayashi, Takashi Komori, Masato Hasegawa, Takeshi Ikeuchi, Yuichi Hayashi, Takayoshi Shimohata, Shigeo Murayama, Yasushi Iwasaki, Toshiki Uchihara, Motoko Sakai, Ichiro Yabe, Satoshi Tanikawa, Hiroshi Takigawa, Tadashi Adachi, Ritsuko Hanajima, Harutoshi Fujimura, Kentaro Hayashi, Keizo Sugaya, Kazuko Hasegawa, Terunori Sano, Masaki Takao, Osamu Yokota, Tomoko Miki, Michio Kobayashi, Nobutaka Arai, Takuya Ohkubo, Takanori Yokota, Keiko Mori, Masumi Ito, Chiho Ishida, Jiro Idezuka, Yasuko Toyoshima, Masato Kanazawa, Masashi Aoki, Takafumi Hasegawa, Hirohisa Watanabe, Atsushi Hashizume, Hisayoshi Niwa, Keizo Yasui, Keita Ito, Yukihiko Washimi, Akatsuki Kubota, Tatsushi Toda, Kenji Nakashima, Ikuko Aiba

    Neuroradiology   2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Due to the indistinguishable clinical features of corticobasal syndrome (CBS), the antemortem differentiation between corticobasal degeneration (CBD) and its mimics remains challenging. However, the utility of conventional magnetic resonance imaging (MRI) for the diagnosis of CBD has not been sufficiently evaluated. This study aimed to investigate the diagnostic performance of conventional MRI findings in differentiating pathologically confirmed CBD from its mimics. METHODS: Semiquantitative visual rating scales were employed to assess the degree and distribution of atrophy and asymmetry on conventional T1-weighted and T2-weighted images. Additionally, subcortical white matter hyperintensity (SWMH) on fluid-attenuated inversion recovery images were visually evaluated. RESULTS: In addition to 19 patients with CBD, 16 with CBD mimics (progressive supranuclear palsy (PSP): 9, Alzheimer's disease (AD): 4, dementia with Lewy bodies (DLB): 1, frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa(FTLD-TDP): 1, and globular glial tauopathy (GGT): 1) were investigated. Compared with the CBD group, the PSP-CBS subgroup showed severe midbrain atrophy without SWMH. The non-PSP-CBS subgroup, comprising patients with AD, DLB, FTLD-TDP, and GGT, showed severe temporal atrophy with widespread asymmetry, especially in the temporal lobes. In addition to over half of the patients with CBD, two with FTLD-TDP and GGT showed SWMH, respectively. CONCLUSION: This study elucidates the distinct structural changes between the CBD and its mimics based on visual rating scales. The evaluation of atrophic distribution and SWMH may serve as imaging biomarkers of conventional MRI for detecting background pathologies.

    DOI： 10.1007/s00234-024-03432-w

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  • A patient with neuronal intranuclear inclusion disease developed encephalitis‐like symptoms after cerebral angiography

    Shin Koide, Shintaro Tsuboguchi, Shingo Koide, Itaru Ninomiya, Taiki Saito, Takanobu Ishiguro, Etsuji Saji, Yo Higuchi, Takeshi Ikeuchi, Makoto Oishi, Masato Kanazawa, Osamu Onodera

    Neurology and Clinical Neuroscience   2024.6

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Patients with neuronal intranuclear inclusion disease (NIID) can present with encephalitis‐like symptoms such as recurrent paroxysmal fever and unconsciousness. To date, no specific triggers for these symptoms have been reported. In our case, an 78‐year‐old woman became unconscious and developed fever after cerebral angiography. The patient had experienced four episodes of unconsciousness and fever in the past 7 years. Postangiography, she immediately became unconscious and developed fever. No vascular abnormalities were found and magnetic resonance imaging of the brain revealed expanding white matter lesions and hyperintense lesions along the corticomedullary junction. Genetic analysis revealed an abnormal GGC repeat expansion in NOTCH2NLC. Thus, we diagnosed the patient with NIID. We suggest that cerebral angiography is a possible trigger for encephalitis‐like symptoms in NIID.

    DOI： 10.1111/ncn3.12839

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  • Cerebellar compensation: a case of aphasia due to cerebellar hemorrhage

    Yukiko Kinoshita, Masahiro Hatakeyama, Mika Otsuki, Takanobu Ishiguro, Etsuji Saji, Masato Kanazawa, Osamu Onodera

    Journal of Neurology   2024.6

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00415-024-12276-6

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  • 造影効果を伴う多発脳病変を呈し,悪性腫瘍との鑑別を要したウイルス性髄膜脳炎の73歳女性の一例

    柏木 健太, 大津 裕, 岸 諒太, 福本 淳貴, 石黒 敬信, 佐治 越爾, 金澤 雅人, 小野寺 理

    臨床神経学   64 ( 6 )   438 - 438   2024.6

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    Language：Japanese   Publisher：(一社)日本神経学会  

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  • Distal CIDPと鑑別を要したが、M蛋白やVEGFの再検が診断に有用であったPOEMS症候群の一例

    鈴木 大介, 鈴木 佑弥, 菊池 謙次, 鈴木 義広, 小出 伸, 安藤 昭一朗, 石黒 敬信, 金澤 雅人, 小野寺 理, 諏訪部 達也, 瀧澤 淳

    臨床神経学   64 ( 5 )   365 - 365   2024.5

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    Language：Japanese   Publisher：(一社)日本神経学会  

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  • 閉塞性睡眠時無呼吸症候群合併多系統萎縮症患者における呼吸イベントと脈拍イベントの検討

    遠藤 優宏, 大嶋 康義, 穂苅 諭, 永井 明日香, 渡部 聡, 小屋 俊之, 金澤 雅人, 中山 秀章, 菊地 利明, 下畑 享良

    日本内科学会雑誌   113 ( 臨増 )   184 - 184   2024.2

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    Language：Japanese   Publisher：(一社)日本内科学会  

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  • Corrigendum: Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke. International journal

    Itaru Ninomiya, Akihide Koyama, Yutaka Otsu, Osamu Onodera, Masato Kanazawa

    Frontiers in cellular neuroscience   18   1372045 - 1372045   2024

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    [This corrects the article DOI: 10.3389/fncel.2023.1225504.].

    DOI： 10.3389/fncel.2024.1372045

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  • Japanese longitudinal biomarker study in progressive supranuclear palsy and corticobasal degeneration: Clinical features of the first registered patients and short-term follow-up analysis

    Hiroshi Takigawa, Ritsuko Hanajima, Ikuko Aiba, Takayoshi Shimohata, Takahiko Tokuda, Mitsuya Morita, Osamu Onodera, Shigeo Murayama, Kazuko Hasegawa, Aya M. Tokumaru, Hisanori Kowa, Masato Kanazawa, Tameto Naoi, Kenji Nakashima, Takeshi Ikeuchi

    Clinical Parkinsonism & Related Disorders   11   100279 - 100279   2024

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.prdoa.2024.100279

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  • Case report: Progressive multifocal leukoencephalopathy co-occurring with neurosarcoidosis: early brain biopsy and appropriate therapy for PML resulted in a favorable prognosis. International journal

    Qiannan Wang, Shintaro Tsuboguchi, Kouichirou Okamoto, Mari Tada, Akiyoshi Kakita, Kazuo Nakamichi, Makoto Oishi, Masato Kanazawa, Osamu Onodera

    Frontiers in immunology   15   1447992 - 1447992   2024

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    Progressive multifocal leukoencephalopathy (PML) is a rare central nervous system disease caused by JC virus (JCV) infection. Human immunodeficiency virus (HIV) infection is the greatest risk factor for PML. Other immunological diseases, including systemic sarcoidosis, have also been reported as risk factors for PML. Herein, we report a case of PML co-occurring with neurosarcoidosis. Early diagnosis using brain biopsy and appropriate therapeutic interventions achieved favorable outcomes. PML in patients with active intracranial neurosarcoidosis is extremely rare. We believe that it is important to perform brain biopsy at an early stage to allow diagnosis, even for central nervous system involvement with a progressive parenchymal lesion in patients with sarcoidosis, if PML is possible.

    DOI： 10.3389/fimmu.2024.1447992

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  • Neuroprotective effects of oral metformin before stroke on cerebral small-vessel disease. International journal

    Natsuki Akiyama, Takayuki Yamashiro, Itaru Ninomiya, Masahiro Uemura, Yorito Hattori, Masafumi Ihara, Osamu Onodera, Masato Kanazawa

    Journal of the neurological sciences   456   122812 - 122812   2023.11

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    BACKGROUND: Metformin (MET) treatment prior to stroke might have neuroprotective effects other than hypoglycemic effects. This study evaluated whether MET treatment prior to stroke is associated with neurological severity and functional outcome in patients with stroke who were not indicated for endovascular treatment and whether the effects of MET differ for each ischemic stroke subtype. METHODS: We investigated 160 type 2 diabetes mellitus patients with ischemic stroke without endovascular treatment who were taking some oral antidiabetic agents prior to stroke in two tertiary hospitals. Lower neurological severity was defined as a National Institutes of Health Stroke Scale score of 3 or lower on admission, and favorable functional outcome was defined as a modified Rankin Scale score = 0-2 at discharge. We analyzed the effects of MET on the neurological severity and functional outcome in each ischemic stroke subtype on logistic regression analysis with adjustments for multiple confounding factors. RESULTS: MET treatment prior to stroke was associated with lower stroke severity and favorable functional outcome. In the stroke subtypes, MET use affected both neurological severity (P = 0.037) and functional outcome (P = 0.041) in only patients with small-vessel disease (SVD). CONCLUSIONS: MET may be useful to improve the outcome of patients with SVD.

    DOI： 10.1016/j.jns.2023.122812

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  • Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome International journal

    Ikuko Aiba, Yuichi Hayashi, Takayoshi Shimohata, Mari Yoshida, Yuko Saito, Koichi Wakabayashi, Takashi Komori, Masato Hasegawa, Takeshi Ikeuchi, Aya M Tokumaru, Keita Sakurai, Shigeo Murayama, Kazuko Hasegawa, Toshiki Uchihara, Yasuko Toyoshima, Yufuko Saito, Ichiro Yabe, Satoshi Tanikawa, Keizo Sugaya, Kentaro Hayashi, Terunori Sano, Masaki Takao, Motoko Sakai, Harutoshi Fujimura, Hiroshi Takigawa, Tadashi Adachi, Ritsuko Hanajima, Osamu Yokota, Tomoko Miki, Yasushi Iwasaki, Michio Kobayashi, Nobutaka Arai, Takuya Ohkubo, Takanori Yokota, Keiko Mori, Masumi Ito, Chiho Ishida, Masaharu Tanaka, Jiro Idezuka, Masato Kanazawa, Kenju Aoki, Masashi Aoki, Takafumi Hasegawa, Hirohisa Watanabe, Atsushi Hashizume, Hisayoshi Niwa, Keizo Yasui, Keita Ito, Yukihiko Washimi, Eiichiro Mukai, Akatsuki Kubota

    Brain Communications   5 ( 6 )   fcad296   2023.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    The clinical presentation of corticobasal degeneration is diverse, while the background pathology of corticobasal syndrome is also heterogeneous. Therefore, predicting the pathological background of corticobasal syndrome is extremely difficult. Herein, we investigated the clinical findings and course in patients with pathologically, genetically and biochemically verified corticobasal degeneration and corticobasal syndrome with background pathology to determine findings suggestive of background disorder. Thirty-two patients were identified as having corticobasal degeneration. The median intervals from the initial symptoms to the onset of key milestones were as follows: gait disturbance, 0.0 year; behavioural changes, 1.0 year; falls, 2.0 years; cognitive impairment, 2.0 years; speech impairment, 2.5 years; supranuclear gaze palsy, 3.0 years; urinary incontinence, 3.0 years; and dysphagia, 5.0 years. The median survival time was 7.0 years; 50% of corticobasal degeneration was diagnosed as corticobasal degeneration/corticobasal syndrome at the final presentation. Background pathologies of corticobasal syndrome (n = 48) included corticobasal degeneration (33.3%), progressive supranuclear palsy (29.2%) and Alzheimer's disease (12.5%). The common course of corticobasal syndrome was initial gait disturbance and early fall. In addition, corticobasal degeneration-corticobasal syndrome manifested behavioural change (2.5 years) and cognitive impairment (3.0 years), as the patient with progressive supranuclear palsy-corticobasal syndrome developed speech impairment (1.0 years) and supranuclear gaze palsy (6.0 years). The Alzheimer's disease-corticobasal syndrome patients showed cognitive impairment (1.0 years). The frequency of frozen gait at onset was higher in the corticobasal degeneration-corticobasal syndrome group than in the progressive supranuclear palsy-corticobasal syndrome group [P = 0.005, odds ratio (95% confidence interval): 31.67 (1.46-685.34)]. Dysarthria at presentation was higher in progressive supranuclear palsy-corticobasal syndrome than in corticobasal degeneration-corticobasal syndrome [P = 0.047, 6.75 (1.16-39.20)]. Pyramidal sign at presentation and personality change during the entire course were higher in Alzheimer's disease-corticobasal syndrome than in progressive supranuclear palsy-corticobasal syndrome [P = 0.011, 27.44 (1.25-601.61), and P = 0.013, 40.00 (1.98-807.14), respectively]. In corticobasal syndrome, decision tree analysis revealed that 'freezing at onset' or 'no dysarthria at presentation and age at onset under 66 years in the case without freezing at onset' predicted corticobasal degeneration pathology with a sensitivity of 81.3% and specificity of 84.4%. 'Dysarthria at presentation and age at onset over 61 years' suggested progressive supranuclear palsy pathology, and 'pyramidal sign at presentation and personality change during the entire course' implied Alzheimer's disease pathology. In conclusion, frozen gait at onset, dysarthria, personality change and pyramidal signs may be useful clinical signs for predicting background pathologies in corticobasal syndrome.

    DOI： 10.1093/braincomms/fcad296

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  • 小脳出血で失語症を呈した一例

    木下 悠紀子, 畠山 公大, 大槻 美佳, 石黒 敬信, 佐治 越爾, 金澤 雅人, 小野寺 理

    臨床神経学   63 ( 11 )   772 - 772   2023.11

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  • Variation of respiratory and pulse events in multiple system atrophy. International journal

    Yasuyoshi Ohshima, Satoshi Hokari, Asuka Nagai, Nobumasa Aoki, Satoshi Watanabe, Toshiyuki Koya, Masato Kanazawa, Hideaki Nakayama, Toshiaki Kikuchi, Takayoshi Shimohata

    Parkinsonism & related disorders   115   105817 - 105817   2023.10

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    DOI： 10.1016/j.parkreldis.2023.105817

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  • Progressive conus medullaris lesions are suggestive of intravascular large B‐cell lymphoma International journal

    Sho Kitahara, Masato Kanazawa, Manabu Natsumeda, Aki Sato, Masanori Ishikawa, Kenju Hara, Hiroyuki Tabe, Kunihiko Makino, Kouichirou Okamoto, Nobuya Fujita, Akiyoshi Kakita, Yukihiko Fuji, Osamu Onodera

    European Journal of Neurology   30 ( 10 )   3236 - 3243   2023.10

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    BACKGROUND AND PURPOSE: Spinal cord lesions are observed in 40% of all central nervous system lesions in intravascular large B-cell lymphoma (IVLBCL). However, because IVLBCL is a very rare disease, its clinical features are not well defined, which may delay appropriate diagnosis and treatment, whilst the acute to subacute course of brain lesions in patients with IVLBCL is well established. Therefore, this study aimed to clarify the clinical features of spinal cord lesions in patients with IVLBCL. METHODS: The medical records of patients with IVLBCL admitted to our hospital between 2010 and 2020 were searched. The inclusion criteria were preceding neurological symptoms without non-neurological symptoms and pathologically confirmed IVLBCL in various organs. Clinical features of spinal cord involvement in patients with IVLBCL were assessed and distinguished from those of brain involvement. RESULTS: Sixteen consecutive patients with IVLBCL were divided into two groups: six patients with spinal involvement (spinal cord type) and 10 patients with brain involvement (brain type). In the spinal cord type, four patients had chronic progression and two had subacute progression. Acute progression (0% vs. 80.0%) and sudden onset (0% vs. 50.0%) occurred significantly less frequently in the spinal cord than in the brain. All spinal cord lesions involved the conus medullaris. CONCLUSIONS: Spinal cord involvement in IVLBCL has a predominantly chronic progressive course that is exclusive to brain involvement. Conus medullaris lesions are suggestive of IVLBCL and are useful for early and accurate diagnosis and treatment.

    DOI： 10.1111/ene.15941

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  • 発作性の神経症状を繰り返し、多発する微小出血像を認めた硬膜移植歴を有する39歳男性例

    畠山 祐樹, 坪口 晋太朗, 石黒 敬信, 佐治 越爾, 畠山 公大, 島田 斉, 金澤 雅人, 小野寺 理

    臨床神経学   63 ( 9 )   603 - 603   2023.9

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  • 脳梗塞発症前のメトホルミン内服による脳小血管病に対する神経保護効果

    秋山 夏葵, 二宮 格, 山城 貴之, 上村 昌寛, 服部 頼都, 猪原 匡史, 小野寺 理, 金澤 雅人

    臨床神経学   63 ( Suppl. )   S310 - S310   2023.9

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  • 発作性の神経症状を繰り返し、多発する微小出血像を認めた硬膜移植歴を有する39歳男性例

    畠山 祐樹, 坪口 晋太朗, 石黒 敬信, 佐治 越爾, 畠山 公大, 島田 斉, 金澤 雅人, 小野寺 理

    臨床神経学   63 ( 9 )   603 - 603   2023.9

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  • Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke International journal

    Itaru Ninomiya, Akihide Koyama, Yutaka Otsu, Osamu Onodera, Masato Kanazawa

    Frontiers in Cellular Neuroscience   17   1225504 - 1225504   2023.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media {SA}  

    Theoretically, direct chemical reprogramming of somatic cells into neurons in the infarct area represents a promising regenerative therapy for ischemic stroke. Previous studies have reported that human fibroblasts and astrocytes transdifferentiate into neuronal cells in the presence of small molecules without introducing ectopic transgenes. However, the optimal combination of small molecules for the transdifferentiation of macrophages into neurons has not yet been determined. The authors hypothesized that a combination of small molecules could induce the transdifferentiation of monocyte-derived macrophages into neurons and that the administration of this combination may be a regenerative therapy for ischemic stroke because monocytes and macrophages are directly involved in the ischemic area. Transcriptomes and morphologies of the cells were compared before and after stimulation using RNA sequencing and immunofluorescence staining. Microscopic analyses were also performed to identify cell markers and evaluate functional recovery by blinded examination following the administration of small molecules after ischemic stroke in CB-17 mice. In this study, an essential combination of six small molecules [CHIR99021, Dorsomorphin, Forskolin, isoxazole-9 (ISX-9), Y27632, and DB2313] that transdifferentiated monocyte-derived macrophages into neurons in vitro was identified. Moreover, administration of six small molecules after cerebral ischemia in model animals generated a new neuronal layer in the infarct cortex by converting macrophages into neuronal cells, ultimately improving neurological function. These results suggest that altering the transdifferentiation of monocyte-derived macrophages by the small molecules to adjust their adaptive response will facilitate the development of regenerative therapies for ischemic stroke.

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  • [Disseminated herpes zoster complicated by lumbosacral polyradiculoneuritis and fibular neuropathy: A case report].

    Kosei Nakamura, Shintaro Tsuboguchi, Itaru Ninomiya, Osamu Ansai, Masato Kanazawa, Osamu Onodera

    Rinsho shinkeigaku = Clinical neurology   63 ( 6 )   359 - 362   2023.6

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    A 74-year-old woman who presented with a skin eruption involving the left lateral leg along the L5 dermatome and widespread eruptions on the buttocks and trunk was diagnosed with disseminated herpes zoster (HZ). She also had left lower extremity muscle weakness. The pattern of distribution of muscle weakness and gadolinium-enhanced magnetic resonance imaging findings indicated polyradiculoneuritis mainly affecting the L5 spinal root. Moreover, we observed severe weakness of the left tibialis anterior muscle. Weakness of the other L5 myotomes reduced after antiviral treatment; however, left tibialis anterior muscle weakness persisted. We concluded that lumbosacral polyradiculoneuritis was attributable to varicella-zoster virus (VZV) infection, which also caused fibular neuropathy in this case. Retrograde transport of the VZV may have infected the fibular nerve throughout the sites of skin eruption. It is important to be mindful of simultaneous nerve root and peripheral nerve involvement in cases of motor paralysis associated with HZ infection.

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  • Heterogenous Genetic, Clinical, and Imaging Features in Patients with Neuronal Intranuclear Inclusion Disease Carrying <i>NOTCH2NLC</i> Repeat Expansion International journal

    Yusran Ady Fitrah, Yo Higuchi, Norikazu Hara, Takayoshi Tokutake, Masato Kanazawa, Kazuhiro Sanpei, Tomone Taneda, Akihiko Nakajima, Shin Koide, Shintaro Tsuboguchi, Midori Watanabe, Junki Fukumoto, Shoichiro Ando, Tomoe Sato, Yohei Iwafuchi, Aki Sato, Hideki Hayashi, Takanobu Ishiguro, Hayato Takeda, Toshiaki Takahashi, Nobuyoshi Fukuhara, Kensaku Kasuga, Akinori Miyashita, Osamu Onodera, Takeshi Ikeuchi

    Brain Sciences   13 ( 6 )   955 - 955   2023.6

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    Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder that is caused by the abnormal expansion of non-coding trinucleotide GGC repeats in NOTCH2NLC. NIID is clinically characterized by a broad spectrum of clinical presentations. To date, the relationship between expanded repeat lengths and clinical phenotype in patients with NIID remains unclear. Thus, we aimed to clarify the genetic and clinical spectrum and their association in patients with NIID. For this purpose, we genetically analyzed Japanese patients with adult-onset NIID with characteristic clinical and neuroimaging findings. Trinucleotide repeat expansions of NOTCH2NLC were examined by repeat-primed and amplicon-length PCR. In addition, long-read sequencing was performed to determine repeat size and sequence. The expanded GGC repeats ranging from 94 to 361 in NOTCH2NLC were found in all 15 patients. Two patients carried biallelic repeat expansions. There were marked heterogenous clinical and imaging features in NIID patients. Patients presenting with cerebellar ataxia or urinary dysfunction had a significantly larger GGC repeat size than those without. This significant association disappeared when these parameters were compared with the total trinucleotide repeat number. ARWMC score was significantly higher in patients who had a non-glycine-type trinucleotide interruption within expanded poly-glycine motifs than in those with a pure poly-glycine expansion. These results suggested that the repeat length and sequence in NOTCH2NLC may partly modify some clinical and imaging features of NIID.

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  • Parkinson症候群の治療法開発の最前線 進行性核上性麻痺の新規治療法開発 どのように臨床試験を成功させるか

    金澤 雅人, 春日 健作, 島田 斉, 池内 健, 小野寺 理

    神経治療学   40 ( 3 )   259 - 265   2023.5

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  • Parkinson症候群の治療法開発の最前線 進行性核上性麻痺の新規治療法開発 どのように臨床試験を成功させるか

    金澤 雅人, 春日 健作, 島田 斉, 池内 健, 小野寺 理

    神経治療学   40 ( 3 )   259 - 265   2023.5

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  • 初期にCastleman病が疑われ特徴的な神経伝導検査所見を呈した61歳男性例

    畠山 祐樹, 坪口 晋太朗, 石黒 敬信, 佐治 越爾, 細島 康宏, 片桐 隆幸, 金澤 雅人, 小野寺 理

    臨床神経学   63 ( 4 )   240 - 240   2023.4

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  • 脳血管造影検査後の発熱・意識障害で診断された神経核内封入体病(NIID)の一例

    小出 伸, 坪口 晋太朗, 二宮 格, 齋藤 太希, 石黒 敬信, 佐治 越爾, 鈴木 倫明, 金澤 雅人, 小野寺 理

    臨床神経学   63 ( 3 )   180 - 180   2023.3

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  • Frequency of anti-IgLON5 disease in patients who meet the clinical diagnostic criteria for progressive supranuclear palsy/corticobasal syndrome

    Masato Kanazawa

    Neurology   2023

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    DOI： 10.1212/WNL.0000000000202665

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  • Diagnostic Challenges in HTRA1-related CSVD: Insights from Two Misdiagnosed Cases

    Masato Kanazawa

    Cerebrovascular Diseases   2023

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  • High frequency of<i>HTRA1</i>AND<i>ABCC6</i>mutations in Japanese patients with adult-onset cerebral small vessel disease

    Masahiro Uemura, Yuya Hatano, Hiroaki Nozaki, Shoichiro Ando, Hajime Kondo, Akira Hanazono, Akira Iwanaga, Hiroyuki Murota, Yosuke Osakada, Masato Osaki, Masato Kanazawa, Mitsuyasu Kanai, Yoko Shibata, Reiko Saika, Tadashi Miyatake, Hitoshi Aizawa, Takeshi Ikeuchi, Hidekazu Tomimoto, Ikuko Mizuta, Toshiki Mizuno, Tomohiko Ishihara, Osamu Onodera

    Journal of Neurology, Neurosurgery &amp; Psychiatry   94 ( 1 )   jnnp - 2022   2022.10

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    DOI： 10.1136/jnnp-2022-329917

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  • Patients with heterozygous HTRA1-related cerebral small vessel disease misdiagnosed with other diseases: Two case reports Reviewed

    Masato Kanazawa

    Clinical Neurology and Neurosurgery   223   2022.10

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    DOI： 10.1016/J.CLINEURO.2022.107502

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  • 脳梗塞に対する低酸素低糖刺激末梢血単核球投与による脳内変化

    金山 武史, 畠山 公大, 大津 裕, 秋山 夏葵, 二宮 格, 小野寺 理, 下畑 享良, 金澤 雅人

    脳循環代謝   34 ( 1 )   154 - 154   2022.10

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  • Dysarthria-facial paresis syndrome due to long insular artery infarction

    Ryutaro Hanyu, Shintaro Tsuboguchi, Itaru Ninomiya, Takanobu Ishiguro, Takuya Konno, Masato Kanazawa, Osamu Onodera

    Journal of the Neurological Sciences   442   120456 - 120456   2022.10

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    DOI： 10.1016/j.jns.2022.120456

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  • 神経症状で初発する血管内大細胞型B細胞リンパ腫の臨床的特徴と診断方法に関する検討

    北原 匠, 金澤 雅人, 徳武 孝充, 棗田 学, 佐藤 晶, 石川 正典, 原 賢寿, 田部 浩行, 牧野 邦比古, 藤田 信也, 岡本 浩一郎, 柿田 明美, 藤井 幸彦, 小野寺 理

    臨床神経学   62 ( Suppl. )   S272 - S272   2022.10

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  • パーキンソン症候群の治療法開発の最前線 PSPの新規治療法開発 どのように臨床試験を成功させるか

    金澤 雅人, 春日 健作, 島田 斉, 池内 健, 小野寺 理

    神経治療学   39 ( 6 )   S118 - S118   2022.10

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  • 失語症を来した小脳出血の1例

    畠山 公大, 大槻 美佳, 木下 悠紀子, 小出 伸, 畠山 祐樹, 佐治 越爾, 金澤 雅人, 小野寺 理

    日本神経心理学会総会プログラム・予稿集   46回   69 - 69   2022.8

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  • 2,2,6,6-Tetramethylpiperidine-1-oxyl acts as a volatile inhibitor of ferroptosis and neurological injury International journal

    Hiroyuki Mizuno, Chisato Kubota, Yuta Takigawa, Ryosuke Shintoku, Naokatsu Kannari, Takako Muraoka, Hideru Obinata, Yuhei Yoshimoto, Masato Kanazawa, Ichiro Koshiishi, Seiji Torii

    The Journal of Biochemistry   172 ( 2 )   71 - 78   2022.5

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    Ferroptosis, a type of oxidative stress cell death, has been implicated in cell injury in several diseases, and treatments with specific inhibitors have been shown to protect cells and tissues. Here we demonstrated that a treatment with the nitroxide radical, 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), prevented the ferroptotic cell death in an airborne manner. Other TEMPO derivatives and lipophilic antioxidants, such as Trolox and ferrostatin-1, also prevented cell death induced by erastin and RSL3; however, only TEMPO exhibited inhibitory activity from a physically distant location. TEMPO vaporized without decomposing, and then dissolved again into a nearby water solution. Volatilized TEMPO inhibited glutamate-induced cell death in mouse hippocampal cell lines, and also reduced neuronal cell death in a mouse ischemia model. These results suggest that TEMPO is a unique cell protective agent that acts in a volatility-mediated manner.

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  • Neuronal Intranuclear Inclusion Disease Presenting with Voice Tremor International journal

    Tomone Taneda, Masato Kanazawa, Yo Higuchi, Hironori Baba, Aiko Isami, Masahiro Uemura, Takuya Konno, Arata Horii, Takeshi Ikeuchi, Osamu Onodera

    Movement Disorders Clinical Practice   9 ( 3 )   404 - 406   2022.4

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    DOI： 10.1002/mdc3.13382

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  • 海綿静脈洞に炎症が波及したリンパ球性下垂体炎の41歳女性例

    木村 嘉克, 上村 昌寛, 森 秀樹, 今野 卓哉, 金澤 雅人, 小野寺 理, 岡本 浩一郎

    臨床神経学   62 ( 4 )   307 - 307   2022.4

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  • 膵神経内分泌腫瘍の治療中に多発脳梗塞を生じた41歳男性例

    遠山 玄理, 上村 昌寛, 中村 航世, 寺本 傑, 秋山 夏葵, 今野 卓哉, 金澤 雅人, 小野寺 理

    臨床神経学   62 ( 4 )   319 - 319   2022.4

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  • Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model. International journal

    Masato Kanazawa

    The Journal of clinical investigation   131 ( 22 )   2021.11

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    Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a hereditary form of CSVD caused by loss of high-temperature requirement A1 (HTRA1) serine protease activity. In CARASIL, arteriopathy causes intimal thickening, smooth muscle cell (SMC) degeneration, elastic lamina splitting, and vasodilation. The molecular mechanisms were proposed to involve the accumulation of matrisome proteins as substrates or abnormalities in transforming growth factor β (TGF-β) signaling. Here, we show that HTRA1-/- mice exhibited features of CARASIL-associated arteriopathy: intimal thickening, abnormal elastic lamina, and vasodilation. In addition, the mice exhibited reduced distensibility of the cerebral arteries and blood flow in the cerebral cortex. In the thickened intima, matrisome proteins, including the hub protein fibronectin (FN) and latent TGF-β binding protein 4 (LTBP-4), which are substrates of HTRA1, accumulated. Candesartan treatment alleviated matrisome protein accumulation and normalized the vascular distensibility and cerebral blood flow. Furthermore, candesartan reduced the mRNA expression of Fn1, Ltbp-4, and Adamtsl2, which are involved in forming the extracellular matrix network. Our results indicate that these accumulated matrisome proteins may be potential therapeutic targets for arteriopathy in CARASIL.

    DOI： 10.1172/jci140555

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  • ラット脳虚血後のリン酸化タウ発現の経時変化

    大津 裕, 金山 武史, 二宮 格, 畠山 公大, 小野寺 理, 金澤 雅人

    脳循環代謝   33 ( 1 )   96 - 96   2021.11

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  • 神経核内封入体病(NIID)におけるNOTCH2NLCリピート伸長と臨床的特徴の検討

    樋口 陽, 原 範和, Yusran Ady Fitrah, 種田 朝音, 徳武 孝允, 三浦 健, 岩淵 洋平, 五十嵐 修一, 林 秀樹, 石黒 敬信, 三瓶 一弘, 武田 勇人, 高橋 俊昭, 金澤 雅人, 宮下 哲典, 小野寺 理, 池内 健

    Dementia Japan   35 ( 4 )   612 - 612   2021.10

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  • Do patients with multiple system atrophy have decreased nocturnal urinary concentration? International journal

    Sakata, Y., Kanazawa, M., Hatakeyama, M., Konno, T., Ozawa, T., Onodera, O.

    Clinical Autonomic Research   31 ( 6 )   2021.9

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    DOI： 10.1007/s10286-021-00826-1

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  • 小字症を呈した自己免疫性脳幹脳炎の臨床的特徴

    助川 真響, 畠山 公大, 羽入 龍太郎, 滑川 将気, 大津 裕, 橋田 裕美, 金澤 雅人, 小野寺 理

    臨床神経学   61 ( Suppl. )   S431 - S431   2021.9

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  • 小字症を呈した自己免疫性脳幹脳炎の臨床的特徴

    助川 真響, 畠山 公大, 羽入 龍太郎, 滑川 将気, 大津 裕, 橋田 裕美, 金澤 雅人, 小野寺 理

    臨床神経学   61 ( Suppl. )   S431 - S431   2021.9

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  • Progressive micrographia without parkinsonism caused by autoimmune brainstem encephalitis: A case report Reviewed International journal

    Ryutaro Hanyu, Masahiro Hatakeyama, Masaki Namekawa, Yutaka Otsu, Mayura Sukegawa, Hiromi Hashida, Izumi Kawachi, Masato Kanazawa, Osamu Onodera

    Clinical Neurology and Neurosurgery   202   106496 - 106496   2021.3

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    DOI： 10.1016/j.clineuro.2021.106496

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  • Genetic Variations and Neuropathologic Features of Patients with PRKN Mutations Reviewed International journal

    Seike, N., Yokoseki, A., Takeuchi, R., Saito, K., Miyahara, H., Miyashita, A., Ikeda, T., Aida, I., Nakajima, T., Kanazawa, M., Wakabayashi, M., Toyoshima, Y., Takahashi, H., Matsumoto, R., Toda, T., Onodera, O., Ishikawa, A., Ikeuchi, T., Kakita, A.

    Movement Disorders   36 ( 7 )   1634 - 1643   2021.2

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    DOI： 10.1002/mds.28521

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mds.28521

  • 医学と医療の最前線 脳梗塞に対する細胞療法の最前線

    畠山 公大, 二宮 格, 小野寺 理, 下畑 享良, 金澤 雅人

    日本内科学会雑誌   110 ( 1 )   117 - 123   2021.1

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  • Corrigendum: HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade. International journal

    Masahiro Uemura, Hiroaki Nozaki, Akihide Koyama, Naoko Sakai, Shoichiro Ando, Masato Kanazawa, Taisuke Kato, Osamu Onodera

    Frontiers in neurology   12   756038 - 756038   2021

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    DOI： 10.3389/fneur.2021.756038

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  • Strategies to prevent hemorrhagic transformation after reperfusion therapies for acute ischemic stroke: A literature review. Reviewed International journal

    Yutaka Otsu, Masaki Namekawa, Masafumi Toriyabe, Itaru Ninomiya, Masahiro Hatakeyama, Masahiro Uemura, Osamu Onodera, Takayoshi Shimohata, Masato Kanazawa

    Journal of the neurological sciences   419   117217 - 117217   2020.11

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    DOI： 10.1016/j.jns.2020.117217

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  • 脳梗塞に対する低酸素低糖刺激末梢血単核球を用いた細胞療法

    畠山 公大, 金澤 雅人, 二宮 格, 尾前 薫, 木村 泰子, 高橋 哲哉, 小野寺 理, 福島 雅典, 下畑 享良

    脳循環代謝   32 ( 1 )   81 - 81   2020.11

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  • ラクナ梗塞とBranch atheromatous diseaseの鑑別における、入院時血清PTX3値の有用性の検討

    二宮 格, 金澤 雅人, 上村 昌寛, 小野寺 理

    脳循環代謝   32 ( 1 )   113 - 113   2020.11

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  • ラクナ梗塞とBranch atheromatous diseaseの鑑別における、入院時血清PTX3値の有用性

    金澤 雅人, 二宮 格, 上村 昌寛, 下畑 享良, 小野寺 理

    臨床神経学   60 ( Suppl. )   S360 - S360   2020.11

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  • 著明な疼痛と異常感覚で発症した筋萎縮性側索硬化症の1例

    池上 いちこ, 畠山 公大, 羽入 龍太郎, 滑川 将気, 大津 裕, 金澤 雅人, 小野寺 理

    臨床神経生理学   48 ( 5 )   587 - 587   2020.10

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  • 脳梗塞に対する低酸素低糖刺激末梢血単核球療法

    畠山 公大, 二宮 格, 小野寺 理, 下畑 享良, 金澤 雅人

    BRAIN and NERVE: 神経研究の進歩   72 ( 10 )   1097 - 1103   2020.10

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    池上 いちこ, 畠山 公大, 羽入 龍太郎, 滑川 将気, 大津 裕, 金澤 雅人, 小野寺 理

    臨床神経生理学   48 ( 5 )   587 - 587   2020.10

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  • progressive型の小字症と運動失調を呈した自己免疫性脳幹脳炎の1例

    畠山 公大, 羽入 龍太郎, 滑川 将気, 大津 裕, 橋田 裕美, 金澤 雅人, 小野寺 理

    日本神経心理学会総会プログラム・予稿集   44回   103 - 103   2020.9

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  • Cell therapies under clinical trials and polarized cell therapies in pre-clinical studies to treat ischemic stroke and neurological diseases: A literature review Reviewed International journal

    Hatakeyama, M., Ninomiya, I., Otsu, Y., Omae, K., Kimura, Y., Onodera, O., Fukushima, M., Shimohata, T., Kanazawa, M.

    International Journal of Molecular Sciences   21 ( 17 )   2020.8

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  • 肺血栓塞栓症を合併し、奇異性塞栓による後脊髄動脈症候群を呈した潰瘍性大腸炎の56歳女性例

    荻根沢 真也, 上村 昌寛, 大津 裕, 徳武 孝允, 金澤 雅人, 小野寺 理

    臨床神経学   60 ( 5 )   367 - 367   2020.5

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  • Elevated serum pentraxin 3 levels might predict the diagnosis of branch atheromatous disease at a very early stage. Reviewed International journal

    Itaru Ninomiya, Masato Kanazawa, Masahiro Umemura, Osamu Onodera

    European journal of neurology   2020.4

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    BACKGROUND: Branch atheromatous disease (BAD) is one of the stroke subtypes caused by occlusion at the origin of a deep penetrating artery of the brain and is associated with a microatheroma or a junctional plaque. Patients with BAD often develop progressive worsening of neurologic deficits, although these patients often present minor stroke with clinical characteristics of lacunar syndrome at the onset. Pentraxin 3 (PTX3) is known to be a key molecule involved in the pathogenesis of atherosclerosis. Although a high level of serum PTX3 is observed in patients with acute coronary syndrome, there are no reports on PTX3 levels in patients with BAD. This study aimed to investigate whether serum PTX3 levels can distinguish BAD from other stroke subtypes. METHODS: We investigated 93 patients with ischemic stroke. Serum PTX3 levels on admission were measured using enzyme-linked immunosorbent assay in patients with BAD and those of other stroke subtypes (each n ≥ 20). RESULTS: The median PTX3 levels in patients with BAD (4840 pg/mL) were higher than those with other subtypes of stroke (3397 pg/mL in lacunar stroke, 1298 pg/mL in large artery atherosclerosis, 1470 pg/mL in cardioaortic embolism, and 1006 pg/mL in control) (all p < 0.01). CONCLUSION: Our results suggest that elevated serum pentraxin 3 levels might predict the diagnosis of BAD at a very early stage.

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  • 新しい専門医制度に関するシンポジウム〜始まって2年、新しい専門医制度を巡る課題〜 専攻医からの提言 専攻医の立場からの新たな内科専門医制度について

    中村 航世, 佐治 越爾, 金澤 雅人, 小野寺 理

    新潟医学会雑誌   134 ( 4 )   124 - 125   2020.4

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  • Role of RNF213 p.4810K variant in the development of intracranial arterial disease in patients treated with nilotinib. Reviewed International journal

    Masahiro Uemura, Masato Kanazawa, Takuma Yamagishi, Takahiro Nagai, Mami Takahashi, Shingo Koide, Masayoshi Tada, Junsuke Shimbo, Aiko Isami, Kunihiko Makino, Masayoshi Masuko, Kouji Nikkuni, Kouichirou Okamoto, Shuichi Igarashi, Kenichi Morita, Osamu Onodera

    Journal of the neurological sciences   408   116577 - 116577   2020.1

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  • Progressive Supranuclear Palsy with Predominant Cerebellar Ataxia. Reviewed International journal

    Shoichiro Ando, Masato Kanazawa, Osamu Onodera

    Journal of movement disorders   13 ( 1 )   20 - 26   2020.1

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    Progressive supranuclear palsy (PSP) is characterized by supranuclear gaze palsy, dystonic rigidity of the neck and upper trunk, frequent falls and mild cognitive impairment. Cerebellar ataxia is one of the exclusion criteria given by the National Institute of Neurological Disorders and Stroke and the Society for Progressive Supranuclear Palsy. As a result, pathologically proven PSP patients exhibiting cerebellar ataxia have often been misdiagnosed with spinocerebellar degeneration, specifically multiple system atrophy with predominant cerebellar ataxia (MSA-C). However, more recently, it has been recognized that patients with PSP can present with truncal and limb ataxia as their initial symptom and/or main manifestation. These patients can be classified as having PSP with predominant cerebellar ataxia (PSP-C), a new subtype of PSP. Since the development of this classification, patients with PSP-C have been identified primarily in Asian countries, and it has been noted that this condition is very rare in Western communities. Furthermore, the clinical features of PSP-C have been identified, enabling it to be distinguished from other subtypes of PSP and MSA-C. In this review, we describe the clinical and neuropathological features of PSP-C. The hypothesized pathophysiology of cerebellar ataxia in PSP-C is also discussed.

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  • Angiogenesis and neuronal remodeling after ischemic stroke. Reviewed International journal

    Masahiro Hatakeyama, Itaru Ninomiya, Masato Kanazawa

    Neural regeneration research   15 ( 1 )   16 - 19   2020.1

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    Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal models.This raises the possibility that enhancement of angiogenesis is one of the strategies to facilitate functional recovery after ischemic stroke. Blood vessels and neuronal cells communicate with each other using various mediators and contribute to the pathophysiology of cerebral ischemia as a unit. In this mini-review, we discuss how angiogenesis might couple with axonal outgrowth/neurogenesis and work for functional recovery after cerebral ischemia. Angiogenesis occurs within 4 to 7 days after cerebral ischemia in the border of the ischemic core and periphery. Post-ischemic angiogenesis may contribute to neuronal remodeling in at least two ways and is thought to contribute to functional recovery. First, new blood vessels that are formed after ischemia are thought to have a role in the guidance of sprouting axons by vascular endothelial growth factor and laminin/β1-integrin signaling. Second, blood vessels are thought to enhance neurogenesis in three stages: 1) Blood vessels enhance proliferation of neural stem/progenitor cells by expression of several extracellular signals, 2) microvessels support the migration of neural stem/progenitor cells toward the peri-infarct region by supplying oxygen, nutrients, and soluble factors as well as serving as a scaffold for migration, and 3) oxygenation induced by angiogenesis in the ischemic core is thought to facilitate the differentiation of migrated neural stem/progenitor cells into mature neurons. Thus, the regions of angiogenesis and surrounding tissue may be coupled, representing novel treatment targets.

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  • 抗GD1aIgM抗体と抗GT1bIgM抗体が陽性で免疫グロブリン療法が奏功した遠位優位型CIDPの76歳男性例

    羽入 龍太郎, 須貝 章弘, 加藤 怜, 秋山 夏葵, 徳武 孝允, 金澤 雅人, 河内 泉, 小野寺 理

    臨床神経学   60 ( 1 )   87 - 87   2020.1

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  • A Therapeutic Approach Using Peripheral Blood Mononuclear Cells Preconditioned by Oxygenglucose Deprivation in Ischemic Rats

    Masato Kanazawa

    Neurology   2020

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  • HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature. Reviewed International journal

    Masahiro Uemura, Hiroaki Nozaki, Taisuke Kato, Akihide Koyama, Naoko Sakai, Shoichiro Ando, Masato Kanazawa, Nozomi Hishikawa, Yoshinori Nishimoto, Kiran Polavarapu, Atchayaram Nalini, Akira Hanazono, Daisuke Kuzume, Akihiro Shindo, Mohammad El-Ghanem, Arata Abe, Aki Sato, Mari Yoshida, Takeshi Ikeuchi, Ikuko Mizuta, Toshiki Mizuno, Osamu Onodera

    Frontiers in neurology   11   545 - 545   2020

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    DOI： 10.3389/fneur.2020.00545

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  • Publisher Correction: A novel therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation. Reviewed International journal

    Masahiro Hatakeyama, Masato Kanazawa, Itaru Ninomiya, Kaoru Omae, Yasuko Kimura, Tetsuya Takahashi, Osamu Onodera, Masanori Fukushima, Takayoshi Shimohata

    Scientific reports   9 ( 1 )   19913 - 19913   2019.12

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    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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  • TAF15が主要に蓄積したFET病理を伴う筋萎縮性側索硬化症 剖検例の臨床病理学的特徴(Amsotrophic lateral sclerosis with TAF15-predominant FET pathology: clinicopathologic features of an autopsied patient)

    Cui Bo, Tada Mari, Hatano Yuya, Takeshima Akari, Ishihara Tomohiko, Sugai Akihiro, Tokutake Takayoshi, Kanazawa Masato, Onodera Osamu, Kakita Akiyoshi

    新潟医学会雑誌   133 ( 11-12 )   391 - 391   2019.12

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  • A novel therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation. Reviewed International journal

    Masahiro Hatakeyama, Masato Kanazawa, Itaru Ninomiya, Kaoru Omae, Yasuko Kimura, Tetsuya Takahashi, Osamu Onodera, Masanori Fukushima, Takayoshi Shimohata

    Scientific reports   9 ( 1 )   16819 - 16819   2019.11

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    Cell therapies that invoke pleiotropic mechanisms may facilitate functional recovery in patients with stroke. Based on previous experiments using microglia preconditioned by oxygen-glucose deprivation, we hypothesized that the administration of peripheral blood mononuclear cells (PBMCs) preconditioned by oxygen-glucose deprivation (OGD-PBMCs) to be a therapeutic strategy for ischemic stroke. Here, OGD-PBMCs were identified to secrete remodelling factors, including the vascular endothelial growth factor and transforming growth factor-β in vitro, while intra-arterial administration of OGD-PBMCs at 7 days after focal cerebral ischemia prompted expression of such factors in the brain parenchyma at 28 days following focal cerebral ischemia in vivo. Furthermore, administration of OGD-PBMCs induced an increasing number of stage-specific embryonic antigen-3-positive cells both in vitro and in vivo. Finally, it was found to prompt angiogenesis and axonal outgrowth, and functional recovery after cerebral ischemia. In conclusion, the administration of OGD-PBMCs might be a novel therapeutic strategy against ischemic stroke.

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  • [VEGF-A therapeutic target against hemorrhagic transformation after t-PA treatment]. Reviewed

    Masato Kanazawa, Tetsuya Takahashi, Kunio Kawamura, Takayoshi Shimohata

    Rinsho shinkeigaku = Clinical neurology   59 ( 11 )   699 - 706   2019.11

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    Tissue plasminogen activator (t-PA) treatment is beneficial for patients with ischemic stroke within 4.5 h of stroke onset, because the risk of intracerebral hemorrhagic transformation (HT) increases with delayed t-PA treatment. The benefits of t-PA thrombolysis are heavily dependent on time to treatment. Development of vasoprotective drugs that attenuate HT after delayed t-PA treatment might improve the prognosis of stroke patients and extend the therapeutic time window of t-PA and endovascular thrombolysis. An angiogenic factor, vascular endothelial growth factor (VEGF), might be associated with the blood-brain barrier (BBB) disruption after focal cerebral ischemia. By using a rat thromboembolic model, delayed t-PA treatment at 4 h after ischemia promoted expression of VEGF in BBB, matrix metalloproteinase-9 (MMP-9) activation, degradation of BBB components, and HT. We demonstrated that HT was inhibited by intravenous administration of an anti-VEGF neutralizing antibody/VEGF receptor antagonist. In addition, for clinical application, reverse translation studies, a path from bedside to bench, are necessary.

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  • 多系統萎縮症の自律神経障害評価における二分画蓄尿検査の有用性

    坂田 佑輔, 金澤 雅人, 畠山 公大, 今野 卓哉, 小澤 鉄太郎, 小野寺 理

    臨床神経学   59 ( Suppl. )   S306 - S306   2019.11

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  • Branch Atheromatous Diseaseにおける急性期の血清Lox-1値の検討

    二宮 格, 金澤 雅人, 下畑 享良, 小野寺 理

    臨床神経学   59 ( Suppl. )   S323 - S323   2019.11

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  • 【多系統萎縮症-新たな展開】オリーブ橋小脳萎縮症

    中村 航世, 金澤 雅人, 小野寺 理

    Clinical Neuroscience   37 ( 9 )   1057 - 1058   2019.9

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  • 多系統萎縮症の自律神経障害評価における二分画蓄尿検査の有用性

    坂田 佑輔, 金澤 雅人, 畠山 公大, 今野 卓哉, 小澤 鉄太郎, 小野寺 理

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   13回   126 - 126   2019.7

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  • Angiogenesis in the ischemic core: A potential treatment target? Reviewed International journal

    Masato Kanazawa, Tetsuya Takahashi, Masanori Ishikawa, Osamu Onodera, Takayoshi Shimohata, Gregory J Del Zoppo

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   39 ( 5 )   753 - 769   2019.5

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    The ischemic penumbra is both a concept in understanding the evolution of cerebral tissue injury outcome of focal ischemia and a potential therapeutic target for ischemic stroke. In this review, we examine the evidence that angiogenesis can contribute to beneficial outcomes following focal ischemia in model systems. Several studies have shown that, following cerebral ischemia, endothelial proliferation and subsequent angiogenesis can be detected beginning four days after cerebral ischemia in the border of the ischemic core, or in the ischemic periphery, in rodent and non-human primate models, although initial signals appear within hours of ischemia onset. Components of the neurovascular unit, its participation in new vessel formation, and the nature of the core and penumbra responses to experimental focal cerebral ischemia, are considered here. The potential co-localization of vascular remodeling and axonal outgrowth following focal cerebral ischemia based on the definition of tissue remodeling and the processes that follow ischemic stroke are also considered. The region of angiogenesis in the ischemic core and its surrounding tissue (ischemic periphery) may be a novel target for treatment. We summarize issues that are relevant to model studies of focal cerebral ischemia looking ahead to potential treatments.

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  • 【嚥下障害と誤嚥性肺炎】主な神経疾患の嚥下障害の臨床 多系統萎縮症

    安藤 昭一朗, 金澤 雅人, 小野寺 理

    Clinical Neuroscience   37 ( 5 )   555 - 557   2019.5

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  • Pleiotropic protective effects of progranulin in the treatment of ischemic stroke

    Kanazawa, M., Kawamura, K., Takahashi, T., Shimohata, T.

    Progranulin and Central Nervous System Disorders   2019

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    DOI： 10.1007/978-981-13-6186-9_10

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  • HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade. Reviewed International journal

    Masahiro Uemura, Hiroaki Nozaki, Akihide Koyama, Naoko Sakai, Shoichiro Ando, Masato Kanazawa, Taisuke Kato, Osamu Onodera

    Frontiers in neurology   10   693 - 693   2019

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    Background: Mutations in the high-temperature requirement A serine peptidase 1 (HTRA1) cause cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Most carriers for HTRA1 mutations are asymptomatic, but more than 10 mutations have been reported in symptomatic carriers. The molecular differences between the mutations identified in symptomatic carriers and mutations identified only in CARASIL patients are unclear. HTRA1 is a serine protease that forms homotrimers, with each HTRA1 subunit activating the adjacent HTRA1 via the sensor domain of loop 3 (L3) and the activation domain of loop D (LD). Previously, we analyzed four HTRA1 mutant proteins identified in symptomatic carriers and found that they were unable to form trimers or had mutations in the LD or L3 domain. The mutant HTRA1s with these properties are presumed to inhibit trimer-dependent activation cascade. Indeed, these mutant HTRA1s inhibited wild-type (WT) protease activity. In this study, we further analyzed 15 missense HTRA1s to clarify the molecular character of mutant HTRA1s identified in symptomatic carriers. Methods: We analyzed 12 missense HTRA1s identified in symptomatic carriers (hetero-HTRA1) and three missense HTRA1s found only in CARASIL (CARASIL-HTRA1). The protease activity of the purified recombinant mutant HTRA1s was measured using fluorescein isothiocyanate-labeled casein as substrate. Oligomeric structure was evaluated by size-exclusion chromatography. The protease activities of mixtures of WT with each mutant HTRA1 were also measured. Results: Five hetero-HTRA1s had normal protease activity and were excluded from further analysis. Four of the seven hetero-HTRA1s and one of the three CARASIL-HTRA1s were unable to form trimers. The other three hetero-HTRA1s had mutations in the LD domain. Together with our previous work, 10 of 11 hetero-HTRA1s and two of six CARASIL-HTRA1s were either defective in trimerization or had mutations in the LD or L3 domain (P = 0.006). By contrast, eight of 11 hetero-HTRA1s and two of six CARASIL-HTRA1 inhibited WT protease activity (P = 0.162). Conclusions: HTRA1 mutations identified in symptomatic carriers have the property of interfering the trimer-dependent activation cascade of HTRA1.

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  • Predictors of cognitive impairment in multiple system atrophy. Reviewed International journal

    Masahiro Hatakeyama, Tomoe Sato, Tetsuya Takahashi, Masato Kanazawa, Osamu Onodera, Masatoyo Nishizawa, Takayoshi Shimohata

    Journal of the neurological sciences   388   128 - 132   2018.5

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    OBJECTIVE: To determine predictors of cognitive impairment and frontal dysfunction in patients with multiple system atrophy (MSA). METHODS: We recruited 59 patients with MSA and determined the predictors of a decline in the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB) scores. RESULTS: The MMSE scores negatively correlated with disease duration, Unified MSA Rating Scale (UMSARS) part 1 and 4 scores, and residual urine volume, and positively correlated with the coefficient of variation of electrocardiographic RR intervals. The FAB scores negatively correlated with the UMSARS part 2 score, periventricular hyperintensity grade, and deep white matter hyperintense signal grade. A significant predictor of rapidly progressive cognitive impairment was a high residual urine volume. CONCLUSIONS: Impairment of global cognitive function correlates with the long-term disease duration, global disability due to the disease, and autonomic dysfunction, whereas frontal dysfunction correlates with motor function and degeneration of cerebral white matter.

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  • β1-integrin–matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability Reviewed

    Yoshikane Izawa, Yu-Huan Gu, Takashi Osada, Masato Kanazawa, Brian T Hawkins, James A Koziol, Thalia Papayannopoulou, Maria Spatz, Gregory J del Zoppo

    Journal of Cerebral Blood Flow and Metabolism   38 ( 4 )   641 - 658   2018.4

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    DOI： 10.1177/0271678X17722108

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  • 各種疾患 脳血管障害 脳梗塞に対する低酸素・低糖刺激ミクログリアを用いた新規細胞療法

    金澤 雅人, 高橋 哲哉, 小野寺 理, 下畑 享良

    Annual Review神経   2018   166 - 173   2018.1

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  • Apparent diffusion coefficient reduction might be a predictor of poor outcome in patients with posterior reversible encephalopathy syndrome Reviewed

    Itaru Ninomiya, Masato Kanazawa, Yasuhisa Akaiwa, Takayoshi Shimohata, Kouichirou Okamoto, Osamu Onodera, Masatoyo Nishizawa

    JOURNAL OF THE NEUROLOGICAL SCIENCES   381   1 - 3   2017.10

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    DOI： 10.1016/j.jns.2017.08.002

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  • Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke Reviewed

    Masato Kanazawa, Itaru Ninomiya, Masahiro Hatakeyama, Tetsuya Takahashi, Takayoshi Shimohata

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   18 ( 10 )   2135   2017.10

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  • Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats Reviewed

    Masato Kanazawa, Minami Miura, Masafumi Toriyabe, Misaki Koyama, Masahiro Hatakeyama, Masanori Ishikawa, Takashi Nakajima, Osamu Onodera, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata

    SCIENTIFIC REPORTS   7   42582   2017.2

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    DOI： 10.1038/srep42582

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  • Methylmercury Causes Blood-Brain Barrier Damage in Rats via Upregulation of Vascular Endothelial Growth Factor Expression Reviewed

    Tetsuya Takahashi, Masatake Fujimura, Misaki Koyama, Masato Kanazawa, Fusako Usuki, Masatoyo Nishizawa, Takayoshi Shimohata

    PLOS ONE   12 ( 1 )   e0170623   2017.1

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    DOI： 10.1371/journal.pone.0170623

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  • Preconditioned protective microglia by oxygen-glucose deprivation promote functional recovery in ischemic rats

    Masato Kanazawa

    Journal of the Neurological Sciences   2017

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  • Preconditioned M2 microglia by oxygen-glucose deprivation promote functional recovery in ischemic rats

    Masato Kanazawa

    Neurology   2017

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  • Therapeutic strategies to attenuate hemorrhagic transformation after tissue plasminogen activator treatment for acute ischemic stroke

    Kanazawa, M., Takahashi, T., Nishizawa, M., Shimohata, T.

    Journal of Atherosclerosis and Thrombosis   24 ( 3 )   2017

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    DOI： 10.5551/jat.RV16006

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  • Therapeutic Strategies to Attenuate Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment for Acute Ischemic Stroke Reviewed

    Masato Kanazawa, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   24 ( 3 )   240 - 253   2017

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  • Dissociation between intact vibratory sensation and impaired joint position sensation may predict ataxia of spinal origin Reviewed

    Masato Kanazawa, Keiichi Katsumi, Takayoshi Tokutake, Naoto Endo, Osamu Onodera, Masatoyo Nishizawa

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management   6   68 - 70   2016.12

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    DOI： 10.1016/j.inat.2016.09.003

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  • Clinical and imaging findings of progressive supranuclear palsy with predominant cerebellar ataxia Reviewed

    Takayoshi Shimohata, Masato Kanazawa, Mari Yoshida, Yufuko Saito, Katsushige Iwai, Takeshi Yasuda, Akira Inukai, Hitoshi Takahashi, Masatoyo Nishizawa, Ikuko Aiba

    MOVEMENT DISORDERS   31 ( 5 )   760 - 762   2016.5

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  • Neuroprotective effect of progranulin against focal cerebral ischemia via inhibition of proteolysis of TDP-43 by caspase-3 Reviewed

    Masato Kanazawa, Masafumi Toriyabe, Misaki Koyama, Minami Miura, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata

    NEUROLOGY   86   2016.4

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  • [Progranulin]. Reviewed

    Masato Kanazawa

    Nihon rinsho. Japanese journal of clinical medicine   74 ( 4 )   579 - 582   2016.4

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  • A patient with cervical spondylotic myelopathy with ,8f-fdg uptake on positron emission tomography/computed tomography Reviewed

    Naohiro Wakasugi, Masato Kanazawa, Ryuji Yajima, Keiichi Katsumi, Naoto Endo, Masatoyo Nishizawa

    Brain and Nerve   68 ( 2 )   191 - 193   2016.2

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  • Neuroprotective Effect of Progranulin Against Focal Cerebral Ischemia via Inhibition of Proteolysis of TDP-43 by Caspase-3 Reviewed

    Toriyabe Masafumi, Masato Kanazawa, Misaki Koyama, Minami Miura, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata

    STROKE   47   2016.2

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  • Neuroprotective effect of progranulin against focal cerebral ischemia via inhibition of proteolysis of TDP-43 by caspase-3

    Masato Kanazawa

    Neurology   2016

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  • Amnesia as a result of symmetrical infarction of the bilateral fornices

    Masato Kanazawa

    Neurology and Clinical Neuroscience   2016

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  • THE EMBOLIC SOURCE BY DETECTING TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN CRYPTOGENIC STROKE

    Masato Kanazawa

    Journal of Cerebral Blood Flow & Metabolism   2016

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  • Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia Reviewed

    Yu-Huan Gu, Masato Kanazawa, Stephanie Y. Hung, Xiaoyun Wang, Shunichi Fukuda, James A. Koziol, Gregory J. del Zoppo

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   35 ( 11 )   1888 - 1900   2015.11

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    DOI： 10.1038/jcbfm.2015.170

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  • Fluid-fluid levels in lateral ventricles predict bacterial CNS infections Reviewed

    Masato Kanazawa, Naohiro Wakasugi, Masahiro Hatakeyama, Takayoshi Shimohata, Masatoyo Nishizawa

    JOURNAL OF THE NEUROLOGICAL SCIENCES   357 ( 1-2 )   292 - 294   2015.10

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  • Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke Reviewed

    Masato Kanazawa, Kunio Kawamura, Tetsuya Takahashi, Minami Miura, Yoshinori Tanaka, Misaki Koyama, Masafumi Toriyabe, Hironaka Igarashi, Tsutomu Nakada, Masugi Nishihara, Masatoyo Nishizawa, Takayoshi Shimohata

    BRAIN   138 ( Pt 7 )   1932 - 1948   2015.7

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    DOI： 10.1093/brain/awv079

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  • Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death Reviewed

    Tetsuhiko Ikeda, Tetsuya Takahashi, Mika Tsujita, Masato Kanazawa, Masafumi Toriyabe, Misaki Koyama, Kosuke Itoh, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata

    PLOS ONE   10 ( 6 )   e0128844   2015.6

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    DOI： 10.1371/journal.pone.0128844

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  • Apparent diffusion coefficients distinguish amyotrophic lateral sclerosis from cervical spondylotic myelopathy Reviewed

    Yuka Koike, Masato Kanazawa, Kenshi Terajima, Kei Watanabe, Masayuki Ohashi, Naoto Endo, Takayoshi Shimohata, Masatoyo Nishizawa

    CLINICAL NEUROLOGY AND NEUROSURGERY   132   33 - 36   2015.5

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    DOI： 10.1016/j.clineuro.2015.02.009

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  • Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke (vol 138, pg 1932, 2015) Reviewed

    Masato Kanazawa, Kunio Kawamura, Tetsuya Takahashi, Minami Miura, Yoshinori Tanaka, Misaki Koyama, Masafumi Toriyabe, Hironaka Igarashi, Tsutomu Nakada, Masugi Nishihara, Masatoyo Nishizawa, Takayoshi Shimohata

    BRAIN   138   1932 - 1948   2015.4

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    DOI： 10.1093/brain/awx141

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  • Multiple Therapeutic Effects of Progranulin on Experimental Acute Ischemic Stroke Reviewed

    Masato Kanazawa, Kunio Kawamura, Tetsuya Takahashi, Minami Miura, Yoshinori Tanaka, Misaki Koyama, Masafumi Toriyabe, Hironaka Igarashi, Tsutomu Nakada, Masasugi Nishihara, Masatoyo Nishizawa, Takayoshi Shimohata

    STROKE   46   2015.2

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  • Varicella-zoster virus encephalitis localized to the bilateral medial temporal lobes Reviewed

    Ryuji Yajima, Kota Utsumi, Tomohiko Ishihara, Masato Kanazawa, Kouichirou Okamoto, Izumi Kawachi, Masatoyo Nishizawa

    Neurology: Neuroimmunology and NeuroInflammation   2 ( 4 )   e108   2015

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  • Identification of beta 1,3-galactosyltransferases responsible for biosynthesis of insect complex-type N-glycans containing a T-antigen unit in the honeybee

    Masato Kanazawa

    Glycoconjugate Journal   2015

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    DOI： 10.1007/S10719-015-9585-7

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  • Effects of Angiopoietin-1 on Hemorrhagic Transformation and Cerebral Edema after Tissue Plasminogen Activator Treatment for Ischemic Stroke in Rats Reviewed

    Kunio Kawamura, Tetsuya Takahashi, Masato Kanazawa, Hironaka Igarashi, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata

    PLOS ONE   9 ( 6 )   e98639   2014.6

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    DOI： 10.1371/journal.pone.0098639

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  • A patient with granulomatosis with polyangiitis (Wegener's granulomatosis) presenting with diplopia and blepharoptosis: A case report Reviewed

    Makiko Kitahara, Masato Kanazawa, Masahiro Hatakeyama, Fumihiro Yanagimura, Takuro Sakagami, Izumi Kawachi, Masatoyo Nishizawa

    Brain and Nerve   66 ( 7 )   880 - 881   2014

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  • A patient with granulomatosis with polyangiitis (Wegener's granulomatosis) presenting with diplopia and blepharoptosis: A case report Reviewed

    Makiko Kitahara, Masato Kanazawa, Masahiro Hatakeyama, Fumihiro Yanagimura, Takuro Sakagami, Izumi Kawachi, Masatoyo Nishizawa

    Brain and Nerve   66 ( 7 )   880 - 881   2014

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  • Pathognomonic magnetic resonance imaging (MRI) finding of fluid-fluid level in pyogenic ventriculitis: Two case reports Reviewed

    Masahiro Hatakeyama, Masato Kanazawa, Ayako Ishihara, Yoshinari Tanabe, Takayoshi Shimohata, Masatoyo Nishizawa

    Clinical Neurology   54 ( 9 )   732 - 737   2014

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    DOI： 10.5692/clinicalneurol.54.732

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  • Early clinical features of patients with progressive supranuclear palsy with predominant cerebellar ataxia Reviewed

    Masato Kanazawa, Mari Tada, Osamu Onodera, Hitoshi Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata

    PARKINSONISM & RELATED DISORDERS   19 ( 12 )   1149 - 1151   2013.12

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    DOI： 10.1016/j.parkreldis.2013.07.019

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  • Predictors of outcome in hypoglycemic encephalopathy Reviewed

    Tetsuhiko Ikeda, Tetsuya Takahashi, Aki Sato, Hajime Tanaka, Shuichi Igarashi, Nobuya Fujita, Takeo Kuwabara, Masato Kanazawa, Masatoyo Nishizawa, Takayoshi Shimohata

    DIABETES RESEARCH AND CLINICAL PRACTICE   101 ( 2 )   159 - 163   2013.8

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    DOI： 10.1016/j.diabres.2013.05.007

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  • Early Clinical Features in Japanese Patients with Pathologically Proven Progressive Supranuclear Palsy with Cerebellar Ataxia Reviewed

    Masato Kanazawa, Takayoshi Shimohata, Mari Tada, Osamu Onodera, Hitoshi Takahashi, Masatoyo Nishizawa

    NEUROLOGY   80   2013.2

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  • Effects of ALDH2 Agonist, Alda-1, on Hypoglycemic Neuronal Death Associated with Glucose Reperfusion Injury Reviewed

    Tetsuhiko Ikeda, Tetsuya Takahashi, Hironaka Igarashi, Masato Kanazawa, Kosuke Itoh, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata

    NEUROLOGY   80   2013.2

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  • Therapeutic strategies to attenuate hemorrhagic transformation after tissue plasminogen activator treatment for acute ischemic stroke

    Shimohata, T., Kanazawa, M., Kawamura, K., Takahashi, T., Nishizawa, M.

    Neurology and Clinical Neuroscience   1 ( 6 )   2013

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  • Therapeutic strategies to attenuate hemorrhagic transformation after tissue plasminogen activator treatment for acute ischemic stroke

    Masato Kanazawa

    Neurology and Clinical Neuroscience   2013

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  • A serial MRI study in a patient with progressive supranuclear palsy with cerebellar ataxia Reviewed

    Masato Kanazawa, Takayoshi Shimohata, Kotaro Endo, Ryoko Koike, Hitoshi Takahashi, Masatoyo Nishizawa

    PARKINSONISM & RELATED DISORDERS   18 ( 5 )   677 - 679   2012.6

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  • Microglial cell activation is a source of metalloproteinase generation during hemorrhagic transformation Reviewed

    Gregory J. del Zoppo, Harald Frankowski, Yu-Huan Gu, Takashi Osada, Masato Kanazawa, Richard Milner, Xiaoyun Wang, Naohisa Hosomi, Takuma Mabuchi, James A. Koziol

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   32 ( 5 )   919 - 932   2012.5

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    DOI： 10.1038/jcbfm.2012.11

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  • Angiopoietin-1 as a Candidate Molecule for Vasoprotection Against Hemorrhagic Transformation after Treatment with Tissue Plasminogen Activator Reviewed

    Kunio Kawamira, Hironaka Igarashi, Masato Kanazawa, Tetsuya Takahashi, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata

    NEUROLOGY   78   2012.4

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  • Body Temperature and Lactic Acid Level as Prognostic Factors in Hypoglycemic Coma Reviewed

    Tetsuhiko Ikeda, Tetsuya Takahashi, Aki Sato, Hajime Tanaka, Shuichi Igarashi, Nobuya Fujita, Takeo Kuwabara, Masato Kanazawa, Masatoyo Nishizawa, Takayoshi Shimohata

    NEUROLOGY   78   2012.4

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  • Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by beta(1)-integrins Reviewed

    Takashi Osada, Yu-Huan Gu, Masato Kanazawa, Yoshiaki Tsubota, Brian T. Hawkins, Maria Spatz, Richard Milner, Gregory J. del Zoppo

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   31 ( 10 )   1972 - 1985   2011.10

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    DOI： 10.1038/jcbfm.2011.99

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  • Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment Reviewed

    Masato Kanazawa, Hironaka Igarashi, Kunio Kawamura, Tetsuya Takahashi, Akiyoshi Kakita, Hitoshi Takahashi, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   31 ( 6 )   1461 - 1474   2011.6

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    DOI： 10.1038/jcbfm.2011.9

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  • Inhibition of VEGF Signaling Pathway Attenuates Hemorrhagic Transformation after tPA Treatment Reviewed

    Takayoshi Shimohata, Niigata Japan, Masato Kanazawa, Hironaka Igarashi, Tetsuya Takahashi, Kunio Kawamura, Akiyoshi Kakita, Hitoshi Takahashi, Tsutomu Nakada, Masatoyo Nishizawa

    NEUROLOGY   76 ( 9 )   A447 - A448   2011.3

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  • Biochemical and histopathological alterations in TAR DNA-binding protein-43 after acute ischemic stroke in rats Reviewed

    Masato Kanazawa, Akiyoshi Kakita, Hironaka Igarashi, Tetsuya Takahashi, Kunio Kawamura, Hitoshi Takahashi, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata

    JOURNAL OF NEUROCHEMISTRY   116 ( 6 )   957 - 965   2011.3

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    DOI： 10.1111/j.1471-4159.2010.06860.x

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  • MRI Findings of Hypoglycemic Encephalopathy Patients Presenting with Neurological Deficits Reviewed

    Takayoshi Shimohata, Tetsuhiko Ikeda, Tetsuya Takahashi, Masato Kanazawa, Masafumi Toriyabe, Hiroyuki Arakawa, Yasuhisa Akaiwa, Kiyoshi Onda, Yasuo Watanabe, Akihiro Obata, Jirou Idazuka, Masatoyo Nishizawa

    NEUROLOGY   76 ( 9 )   A30 - A31   2011.3

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  • Effect of Hyperglycemia after the Correction of Glucose Level or Decreased Body Temperature on the Prognosis of Patients with Hypoglycemic Coma Reviewed

    Tetsuhiko Ikeda, Tetsuya Takahashi, Masato Kanazawa, Masatoyo Nishizawa, Takayoshi Shimohata

    NEUROLOGY   74 ( 9 )   A477 - A477   2010.3

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  • Cerebellar Involvement in Progressive Supranuclear Palsy: A Clinicopathological Study Reviewed

    Masato Kanazawa, Takayoshi Shimohata, Yasuko Toyoshima, Mari Tada, Akiyoshi Kakita, Takashi Morita, Tetsutaro Ozawa, Hitoshi Takahashi, Masatoyo Nishizawa

    MOVEMENT DISORDERS   24 ( 9 )   1312 - 1318   2009.7

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    DOI： 10.1002/mds.22583

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  • TDP-43 May Contribute To The Protective Effects Of Hypothermia Against Rat Focal Cerebral Ischemia Reviewed

    Masato Kanazawa, Akiyoshi Kakita, Hironaka Igarashi, Tetsuya Takahashi, Hitoshi Takahashi, Masatoyo Nishizawa, Tsutomu Nakada, Takayoshi Shimohata

    STROKE   40 ( 4 )   E223 - E223   2009.4

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  • Caspase 3-Dependent Proteolytic Cleavage of TDP-43 in a Model of Transient Middle Cerebral Artery Occlusion Reviewed

    Masato Kanazawa, Akiyoshi Kakita, Hironaka Igarashi, Tetsuya Takahashi, Hitoshi Takahashi, Masatoyo Nishizawa, Tsutomu Nakada, Takayoshi Shimohata

    NEUROLOGY   72 ( 11 )   A401 - A401   2009.3

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  • Reply: Botulinum toxin a injections improve apraxia of eyelid opening without overt blepharospasm associated with neurodegenerative diseases Reviewed

    Masato Kanazawa, Takayoshi Shimohata, Masatoyo Nishizawa

    MOVEMENT DISORDERS   23 ( 5 )   773 - 774   2008.4

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  • The wide spectrum of clinicopathological manifestations in pathologically proven progressive supranuclear palsy: A study of Japanese patients Reviewed

    Masato Kanazawa, Takayoshi Shimohata, Yasuko Toyoshima, Mari Tada, Akiyoshi Kakita, Tetsutaro Ozawa, Takashi Morita, Hitoshi Takahashi, Masatoya Nishizawa

    NEUROLOGY   70 ( 11 )   A385 - A385   2008.3

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  • Clinical features of patients with myasthenia gravis associated with autoimmune diseases Reviewed

    M. Kanazawa, T. Shimohata, K. Tanaka, M. Nishizawa

    EUROPEAN JOURNAL OF NEUROLOGY   14 ( 12 )   1403 - 1404   2007.12

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    DOI： 10.1111/j.1468-1331.2007.01978.x

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  • Chronic myositis with cardiomyopathy and respiratory failure associated with mild form of organ-specific autoimmune diseases Reviewed

    K. Tanaka, A. Sato, K. Kasuga, M. Kanazawa, K. Yanagawa, M. Umeda, M. Tada, M. Tanaka, M. Nishizawa

    CLINICAL RHEUMATOLOGY   26 ( 11 )   1917 - 1919   2007.11

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    DOI： 10.1007/s10067-007-0698-7

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  • Novel locus for benign hereditary chorea with adult onset maps to chromosome 8q21.3 q23.3. Reviewed International journal

    Takayoshi Shimohata, Kenju Hara, Kazuhiro Sanpei, Jin-ichi Nunomura, Tetsuya Maeda, Izumi Kawachi, Masato Kanazawa, Kensaku Kasuga, Akinori Miyashita, Ryozo Kuwano, Koichi Hirota, Shoji Tsuji, Osamu Onodera, Masatoyo Nishizawa, Yoshiaki Honma

    Brain : a journal of neurology   130 ( Pt 9 )   2302 - 9   2007.9

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    DOI： 10.1093/brain/awm036

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  • Novel locus for benign hereditary chorea with adult onset maps to chromosome 8q21.3-q23.3 Reviewed

    Takayoshi Shimohata, Kenju Hara, Kazuhiro Sanpei, Jin-ichi Nunomura, Tetsuya Maeda, Izumi Kawachi, Masato Kanazawa, Kensaku Kasuga, Akinori Miyashita, Ryozo Kuwano, Koichi Hirota, Shoji Tsuji, Osamu Onodera, Masatoyo Nishizawa, Yoshiaki Honma

    BRAIN   130 ( Pt 9 )   2302 - 2309   2007.9

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    DOI： 10.1093/brain/awm036

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  • An autopsy case of dementia with lewy bodies showing autonomic failure and dementia as the initial symptoms Reviewed

    Masato Kanazawa, Kazuhiro Sanpei, Yasuko Toyoshima, Izumi Kawachi, Yoshiaki Honma, Hitoshi Takahashi

    MOVEMENT DISORDERS   22 ( 8 )   1212 - 1213   2007.6

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  • Botulinum toxin A injections improve apraxia of eyelid opening without overt blepharospasm associated with neurodegenerative diseases Reviewed

    Masato Kanazawa, Takayoshi Shimohata, Masahisa Sato, Osamu Onodera, Keiko Tanaka, Masatoyo Nishizawa

    MOVEMENT DISORDERS   22 ( 4 )   597 - 598   2007.3

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  • New locus for benign hereditary chorea with adult-onset maps to chromosome 8q22.2-q23.3 Reviewed

    Kenju Hara, Takayoshi Shimohata, Sanpei Kazuhiro, Jin-ichi Nunomura, Izumi Kawachi, Masato Kanazawa, Kensaku Kasuga, Akinori Miyashita, Ryozo Kuwano, Koichi Hirota, Shoji Tsuji, Osamu Onodera, Masatoyo Nishizawa, Yoshiaki Honma

    NEUROLOGY   68 ( 12 )   A326 - A327   2007.3

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  • Distinct clinical phenotypes of pathologically proven progressive supranuclear palsy: Richardson's syndrome, PSP-Parkinsonism and PSP-cerebral cortical dysfunction Reviewed

    Masato Kanazawa, Takayoshi Shimohata, Akiyoshi Kakita, Mari Tada, Yasuko Toyoshima, Takashi Morita, Hitoshi Takahashi, Masatoyo Nishizawa

    NEUROLOGY   68 ( 12 )   A49 - A49   2007.3

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  • A Japanese adult form of CPT II deficiency associated with a homozygous F383Y mutation

    Masato Kanazawa

    Neurology   2007

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    DOI： 10.1212/01.WNL.0000267665.44477.85

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  • [A case of coexisting pseudoabducens palsy and vertical gaze palsy mimicking vertical one-and-a-half syndrome due to thalamo-mesencephalic infarction]. Reviewed

    Masato Kanazawa

    No to Shinkei = Brain and Nerve   58 ( 1 )   74 - 75   2006.1

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  • A case of coexisting pseudoabducens palsy and vertical gaze palsy mimicking vertical one-and-a-half syndrome due to thalamo-mesencephalic infarction Reviewed

    Kanazawa, M., Sanpei, K.

    No to shinkei. Brain and nerve.   58 ( 1 )   74 - 75   2006

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  • A patient with sarcoidosis needed differential diagnosis from motor neuron disease Reviewed

    Takashi Koide, Masato Kanazawa, Junsuke Shinbo, Katsuhiro Urayama, Nobuo Yagi, Shoichi Tsuchida, Ken Saito, Hideaki Ishiguro

    Clinical Neurology   45 ( 7 )   485 - 489   2005.7

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  • A patient with sarcoidosis needed differential diagnosis from motor neuron disease Reviewed

    Takashi Koide, Masato Kanazawa, Junsuke Shinbo, Katsuhiro Urayama, Nobuo Yagi, Shoichi Tsuchida, Ken Saito, Hideaki Ishiguro

    Clinical Neurology   45 ( 7 )   485 - 489   2005.7

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  • Recurrent hypertensive brainstem encephalopathy Reviewed

    M Kanazawa, K Sanpei, K Kasuga

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   76 ( 6 )   888 - 890   2005.6

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  • Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report Reviewed

    M Kanazawa, Y Wada, T Ohno, H In, K Yahata, J Izumi, H Tanaka, S Ito, M Ueno, M Nakano, F Gejyo

    CLINICAL RHEUMATOLOGY   23 ( 5 )   456 - 459   2004.10

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    DOI： 10.1007/s10067-004-0911-x

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  • Quantitative evaluation of brainstem involvement in multiple system atrophy by diffusion-weighted MR imaging Reviewed

    M Kanazawa, T Shimohata, K Terajima, O Onodera, K Tanaka, S Tsuji, K Okamoto, M Nishizawa

    JOURNAL OF NEUROLOGY   251 ( 9 )   1121 - 1124   2004.9

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    DOI： 10.1007/s00415-004-0494-0

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  • A case of cystic cavernous angioma accompanied by a fluid-fluid level on magnetic resonance imaging Reviewed

    Masato Kanazawa, Keiichi Nishimaki, Takashi Koide, Jun Maruya, Takashi Minakawa, Jyoichi Heianna, Takaharu Miyauchi, Hideaki Ishiguro

    Brain and Nerve   56 ( 8 )   695 - 699   2004.8

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  • A case of cystic cavernous angioma accompanied by a fluid-fluid level on magnetic resonance imaging Reviewed

    Masato Kanazawa, Keiichi Nishimaki, Takashi Koide, Jun Maruya, Takashi Minakawa, Jyoichi Heianna, Takaharu Miyauchi, Hideaki Ishiguro

    Brain and Nerve   56 ( 8 )   695 - 699   2004.8

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  • [Transient lesion in the isolated cerebral cortex in a case with status epilepticus]. Reviewed

    Masato Kanazawa

    No to Shinkei = Brain and Nerve   56 ( 5 )   434 - 435   2004.5

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  • A case with severe respiratory muscle weakness due to chronic myositis associated with PBC Reviewed

    Kensaku Kasuga, Aki Sato, Masato Kanazawa, Hisashi Kobayashi, Keiko Tanaka, Masatoyo Nishizawa

    Clinical Neurology   44 ( 4-5 )   280 - 285   2004.4

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  • A case with severe respiratory muscle weakness due to chronic myositis associated with PBC Reviewed

    Kensaku Kasuga, Aki Sato, Masato Kanazawa, Hisashi Kobayashi, Keiko Tanaka, Masatoyo Nishizawa

    Clinical Neurology   44 ( 4-5 )   280 - 285   2004.4

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  • Transient lesion in the isolated cerebral cortex in a case with status epilepticus Reviewed

    Kanazawa, M.

    Brain and Nerve   56 ( 5 )   434 - 435   2004

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  • Two Cases of Generalized Tetanus Presenting with Dysphagia as an Initial Symptom Reviewed

    Masato Kanazawa, Hideaki Ishiguro, Osamu Onodera, Kenjiro Yoshikawa, Takashi Koide, Aki Arai, Arika Hasegawa, Ryouichi Nakano, Keiko Tanaka, Masatoyo Nishizawa

    Brain and Nerve   55 ( 11 )   973 - 976   2003.11

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  • Two Cases of Generalized Tetanus Presenting with Dysphagia as an Initial Symptom Reviewed

    Masato Kanazawa, Hideaki Ishiguro, Osamu Onodera, Kenjiro Yoshikawa, Takashi Koide, Aki Arai, Arika Hasegawa, Ryouichi Nakano, Keiko Tanaka, Masatoyo Nishizawa

    Brain and Nerve   55 ( 11 )   973 - 976   2003.11

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  • Emphysematous Lesions Preceding Interstitial Pneumonia in a Case with Rheumatoid Arthritis Reviewed

    Kanazawa M, Ooi H, Suzuki E

    Japanese Journal of Chest Diseases   61 ( 6 )   528 - 536   2002

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MISC

  • 左大脳皮質下梗塞により純粋dystypia,純粋dystextiaを呈した1例

    畠山公大, 金山武史, 徳永沙緒里, 木崎利哉, 坪口晋太朗, 金澤雅人, 小野寺理

    高次脳機能研究   44 ( 1 )   2024

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  • 免疫チェックポイント阻害薬使用中の神経・筋関連有害事象に関する検討

    油谷頌子, 石黒敬信, 金澤雅人, 小野寺理

    日本神経学会学術大会プログラム・抄録集   65th   2024

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  • 非腫瘍性疾患における脳生検の適応決定に有用な画像所見

    木崎利哉, 金澤雅人, 石黒敬信, 棗田学, 岡本浩一郎, 大石誠, 柿田明美, 藤井幸彦, 小野寺理

    日本神経学会学術大会プログラム・抄録集   65th   2024

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  • 肺癌による髄膜癌腫症の早期診断の重要性とその方法

    渡邉緑, 石黒敬信, 渡部聡, 菊地利明, 金澤雅人, 小野寺理

    日本神経学会学術大会プログラム・抄録集   65th   2024

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  • 耳鼻咽喉症状が先行する好酸球性多発血管炎性肉芽腫症は初回治療抵抗性である

    木下悠紀子, 石黒敬信, 佐治越爾, 金澤雅人, 小野寺理

    日本神経学会学術大会プログラム・抄録集   65th   2024

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  • 脳血管造影検査後の発熱・意識障害で診断された神経核内封入体病(NIID)の一例

    小出伸, 坪口晋太朗, 二宮格, 齋藤太希, 石黒敬信, 佐治越爾, 鈴木倫明, 金澤雅人, 小野寺理

    臨床神経学(Web)   63 ( 3 )   2023

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  • Long insular artery梗塞の臨床的検討と冠状断画像の有用性

    羽入龍太郎, 坪口晋太朗, 二宮格, 石黒敬信, 今野卓哉, 金澤雅人, 小野寺理

    日本神経学会学術大会プログラム・抄録集   64th   2023

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  • 初期にCastleman病が疑われ特徴的な神経伝導検査所見を呈した61歳男性例

    畠山祐樹, 坪口晋太朗, 石黒敬信, 佐治越爾, 細島康宏, 片桐隆幸, 金澤雅人, 小野寺理

    臨床神経学(Web)   63 ( 4 )   2023

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  • 脳脊髄液中CEA測定を行った髄膜癌腫症9例の検討

    渡邉緑, 石黒敬信, 庄子聡, 金澤雅人, 小野寺理

    日本神経学会学術大会プログラム・抄録集   64th   2023

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  • 脳生検症例における診断と予後についての後方視的検討

    木崎利哉, 石黒敬信, 棗田学, 大石誠, 柿田明美, 藤井幸彦, 小野寺理, 金澤雅人

    日本神経学会学術大会プログラム・抄録集   64th   2023

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  • 進行性多巣性白質脳症に神経サルコイドーシスを合併した65歳女性

    王倩楠, 坪口晋太朗, 木崎利哉, 小出伸, 山岸拓磨, 佐治越爾, 石黒敬信, 金澤雅人, 小野寺理

    神経治療学(Web)   40 ( 6 )   2023

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  • 発作性の神経症状を繰り返し,多発する微小出血像を認めた硬膜移植歴を有する39歳男性例

    畠山祐樹, 坪口晋太朗, 石黒敬信, 佐治越爾, 畠山公大, 島田斉, 金澤雅人, 小野寺理

    臨床神経学(Web)   63 ( 9 )   2023

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  • Development of novel disease-modifying therapies against progressive supranuclear palsy -How to conduct successful clinical trials-

    金澤雅人, 春日健作, 島田斉, 池内健, 小野寺理

    神経治療学(Web)   40 ( 3 )   2023

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  • CPC : 何が起きていたのか?最終病理診断からのメッセージ : 亜急性進行性の巣症状と腎梗塞を併発した66歳の男性—CPC A case of subacute progressive focal neurological symptoms with renal infarction—第119回日本内科学会講演会(2022年)

    上條 祐司, 長谷川 絵理子, 岩渕 洋平, 下島 恭弘, 田澤 浩一, 和田 庸子, 金澤 雅人, 小林 大介, 柿田 明美, 瀧澤 淳, 鋪野 紀好, 松本 正孝, 須永 眞司

    日本内科学会雑誌   111 ( 9 )   1969 - 1985   2022.9

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  • 進行性の認知機能低下を認めたヘテロ接合性HTRA1関連脳小血管病の2症例

    北原匠, 上村昌寛, 坪口晋太朗, 野崎洋明, 金澤雅人, 小野寺理

    Dementia Japan   36 ( 4 )   2022

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  • 多発性硬化症と誤診されたヘテロ接合性HTRA-1関連脳小血管病の1例

    北原匠, 坪口晋太朗, 上村昌寛, 野崎洋明, 今野卓哉, 金澤雅人, 小野寺理

    臨床神経学(Web)   62 ( 8 )   2022

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  • 神経核内封入体病(NIID)におけるNOTCH2NLC GGCリピート数と臨床所見,画像所見の比較

    樋口陽, 樋口陽, YUSRAN Ady Fitrah, 原範和, 種田朝音, 徳武孝允, 三浦健, 岩淵洋平, 五十嵐修一, 林秀樹, 石黒敬信, 三瓶一弘, 武田勇人, 高橋俊昭, 福原信義, 金澤雅人, 宮下哲典, 小野寺理, 池内健

    Dementia Japan   36 ( 4 )   2022

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  • [Rethinking Lacunar Stroke: Beyond Fisher's Curse].

    Osamu Onodera, Masahiro Uemura, Shoichiro Ando, Hideki Hayashi, Masato Kanazawa

    Brain and nerve = Shinkei kenkyu no shinpo   73 ( 9 )   991 - 998   2021.9

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    Lipohyalinosis is an important concept in the independence of lacunar stroke; however, its role has been overemphasized and has led to much confusion in the understanding of lacunar stroke. Classical lipohyalinosis has declined following the widespread availability of antihypertensive therapy, and lacunar stroke secondary to age-related hyaline atherosclerosis is more commonly observed in clinical practice. Clinically diagnosed lacunar stroke is associated with several etiopathogenetic contributors. Excluding cardiogenic embolism, lacunar stroke can be categorized based on the detection of an atheroma. Atheroma imaging is possible in recent years, and strokes that are not associated with an atheroma are shown to present with deep white matter hyperintensity on MRI. Additionally, risk gene analysis has confirmed a group of risk genes associated with the extracellular matrix in lacunar stroke with white matter hyperintensity on MRI. These findings suggest the role of a variety of etiopathogenetic mechanisms underlying lacunar stroke and that lacunar stroke with deep white matter hyperintensity on MRI may be attributable to unique pathogenetic contributors. This group is known to be strongly associated with genetic contributors. Hopefully, lacunar stroke will be diagnosed from this perspective with the development of interventional strategies tailored to the pathogenesis of this condition.

    DOI： 10.11477/mf.1416201876

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  • [Cell Therapy Using Peripheral Mononuclear Cells Preconditioned by Oxygen-Glucose Deprivation for Ischemic Stroke]. Reviewed

    Masahiro Hatakeyama, Itaru Ninomiya, Osamu Onodera, Takayoshi Shimohata, Masato Kanazawa

    Brain and nerve = Shinkei kenkyu no shinpo   72 ( 10 )   1097 - 1103   2020.10

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    Many studies in recent years have reported cell therapies using embryonic stem cells, induced pluripotent stem cells, and bone marrow-derived mononuclear cells for cerebral ischemia. However, obtaining these cells is challenging, and these cell therapies require complicated procedures to prepare cells for administration. Notably, peripheral blood mononuclear cells (PBMCs) are a useful cell source for clinical applications because cell collection is easier. In this review, we report the therapeutic effects of PBMCs preconditioned by oxygen-glucose deprivation (OGD-PBMCs) on cerebral ischemia. Cell therapies using tissue-protective OGD-PBMCs might be a simple and ideal therapeutic strategy against ischemic stroke.

    DOI： 10.11477/mf.1416201655

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  • 肺血栓塞栓症を合併し、奇異性塞栓による後脊髄動脈症候群を呈した潰瘍性大腸炎の56歳女性例 Reviewed

    荻根沢 真也, 上村 昌寛, 大津 裕, 徳武 孝允, 金澤 雅人, 小野寺 理

    臨床神経学   60 ( 5 )   367 - 367   2020.5

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  • Multiple System Atrophy Patients Might Develop Nocturnal Urinary Concentration Failure Prior to Orthostatic Hypotension Early in the Disease Course

    Yusuke Sakata, Masato Kanazawa, Masahiro Hatakeyama, Takuya Konno, Tetsutaro Ozawa, Osamu Onodera

    NEUROLOGY   94 ( 15 )   2020.4

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  • Frequencies of Hereditary Cerebral Small Vessel Diseases Among Patients With Adult-Onset Leukoencephalopathy

    Masahiro Uemura, Hiroaki Nozaki, Naoko Sakai, Shouichirou Ando, Masato Kanazawa, Hajime Kondo, Akira Iwanaga, Hiroyuki Murota, Takeshi Ikeuchi, Ikuko Mizuta, Toshiki Mizuno, Osamu Onodera

    STROKE   51   2020.2

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  • 抗GD1aIgM抗体と抗GT1bIgM抗体が陽性で免疫グロブリン療法が奏功した遠位優位型CIDPの76歳男性例

    羽入 龍太郎, 須貝 章弘, 加藤 怜, 秋山 夏葵, 徳武 孝允, 金澤 雅人, 河内 泉, 小野寺 理

    臨床神経学   60 ( 1 )   87 - 87   2020.1

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  • 脳梗塞に対する低酸素低糖刺激末梢血単核球を用いた細胞療法

    畠山公大, 金澤雅人, 二宮格, 尾前薫, 木村泰子, 高橋哲哉, 小野寺理, 福島雅典, 下畑享良

    脳循環代謝(Web)   32 ( 1 )   2020

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  • 多系統萎縮症の自律神経障害評価における二分画蓄尿検査の有用性

    坂田 佑輔, 金澤 雅人, 畠山 公大, 今野 卓哉, 小澤 鉄太郎, 小野寺 理

    臨床神経学   59 ( Suppl. )   S306 - S306   2019.11

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  • Branch Atheromatous Diseaseにおける急性期の血清Lox-1値の検討

    二宮 格, 金澤 雅人, 下畑 享良, 小野寺 理

    臨床神経学   59 ( Suppl. )   S323 - S323   2019.11

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  • 多系統萎縮症における認知機能低下の予測因子の検討

    下畑 享良, 畠山 公大, 佐藤 朋江, 高橋 哲哉, 金澤 雅人, 小野寺 理, 西澤 正豊

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   12回   89 - 89   2018.7

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  • 【パーキンソン病(第2版)-基礎・臨床研究のアップデート-】 検査・診断 関連疾患 進行性核上性麻痺 臨床病型の多様性およびパーキンソン病との鑑別診断

    金澤 雅人, 小野寺 理, 饗場 郁子

    日本臨床   76 ( 増刊4 パーキンソン病 )   330 - 337   2018.5

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  • 【パーキンソン病(第2版)-基礎・臨床研究のアップデート-】 検査・診断 関連疾患 進行性核上性麻痺 臨床病型の多様性およびパーキンソン病との鑑別診断

    金澤 雅人, 小野寺 理, 饗場 郁子

    日本臨床   76 ( 増刊4 パーキンソン病 )   330 - 337   2018.5

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  • 各種疾患 脳血管障害 脳梗塞に対する低酸素・低糖刺激ミクログリアを用いた新規細胞療法

    金澤 雅人, 高橋 哲哉, 小野寺 理, 下畑 享良

    Annual Review神経   2018   166 - 173   2018.1

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  • 脳梗塞後遺症の機能回復を目指した低酸素低糖刺激保護的ミクログリア細胞療法

    金澤 雅人, 三浦 南, 鳥谷部 真史, 小山 美咲, 畠山 公大, 石川 正典, 中島 孝, 小野寺 理, 高橋 哲哉, 西澤 正豊, 下畑 享良

    脳循環代謝   29 ( 1 )   157 - 157   2017.11

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  • β1-integrin modulates cerebral microvascular tight junction expression and permeability(和訳中)

    伊澤 良兼, Gu Yu-Huan, 長田 高志, 金澤 雅人, Hawkins Brian T, Koziol James A, Papayannopoulou Thalia, Spatz Maria, Zoppo Gregory J.del

    脳循環代謝   29 ( 1 )   174 - 174   2017.11

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  • 多系統萎縮症における認知機能低下の予測因子の検討

    畠山 公大, 佐藤 朋江, 高橋 哲哉, 金澤 雅人, 小野寺 理, 西澤 正豊, 下畑 享良

    Dementia Japan   31 ( 4 )   597 - 597   2017.10

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  • 感覚性運動失調型ニューロパチーと鑑別を要した脊椎疾患の2例

    畠野 雄也, 金澤 雅人, 林 秀樹, 青山 あずさ, 須貝 章弘, 徳武 孝允, 下畑 享良, 小野寺 理

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   11回   102 - 102   2017.10

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  • 多系統萎縮症における認知機能低下の予測因子の検討

    畠山 公大, 佐藤 朋江, 高橋 哲哉, 金澤 雅人, 小野寺 理, 西澤 正豊, 下畑 享良

    Dementia Japan   31 ( 4 )   597 - 597   2017.10

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  • 脳梗塞後の機能回復を目指したミクログリアによる細胞療法

    金澤 雅人, 高橋 哲哉, 小野寺 理, 下畑 享良

    脳循環代謝   28 ( 2 )   315 - 320   2017.8

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  • Predictors of cognitive impairment in multiple system atrophy

    M. Hatakeyama, T. Sato, T. Takahashi, M. Kanazawa, O. Onodera, M. Nishizawa

    MOVEMENT DISORDERS   32   2017.6

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  • Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats

    M. Kanazawa, M. Miura, M. Toriyabe, M. Koyama, M. Hatakeyama, M. Ishikawa, T. Nakajima, O. Onodera, T. Takahashi, M. Nishizawa, T. Shimohata

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   37   262 - 263   2017.4

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  • 低血糖脳症の予後因子に関する検討

    池田 哲彦, 高橋 哲哉, 金澤 雅人, 西澤 正豊, 下畑 享良

    糖尿病   60 ( Suppl.1 )   S - 253   2017.4

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  • 【PSPとCBD-その共通点と相違点】 進行性核上性麻痺(PSP) 小脳型進行性核上性麻痺(PSP-C)

    金澤 雅人, 下畑 享良, 小野寺 理

    Clinical Neuroscience   35 ( 3 )   299 - 301   2017.3

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  • 振動覚の伝導経路に関する臨床的考察

    金澤 雅人, 西澤 正豊

    臨床神経学   56 ( Suppl. )   S536 - S536   2016.12

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  • プログラニュリンによる新規脳保護脳梗塞治療薬の開発

    金澤 雅人

    上原記念生命科学財団研究報告集   30   1 - 8   2016.12

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    ラットとマウス再灌流一過性局所脳虚血モデルにおいてプログラニュリン(PGRN)の虚血後の発現を確認した。初代培養細胞(神経細胞、ミクログリア、アストロサイト)に低酸素低グルコース刺激(OGD)を行い、PGRNや各種サイトカイン、血管破綻に関与する血管内皮増殖因子(VEGF)の産生について検討した。ラット脳塞栓モデルに組換えPGRNをtPAと同時投与し、予後を改善できるか検証した。PGRNは非虚血時、大脳皮質の神経細胞にのみに発現しているが、虚血再灌流後、虚血中心の辺縁部で経時的にPGRN陽性ミクログリアが増加し、虚血ペナンブラで神経細胞、ミクログリア、血管内皮細胞のPGRNの発現が増加した。虚血後に完全糖鎖修飾型PGRN(〜88kDa)の発現が減少するが、虚血中心、虚血ペナンブラ共に、不完全糖鎖修飾型PGRN(58〜68kDa)の発現が再灌流72時間後に著しく増加した。神経細胞を用いたOGD実験では、組換えPGRNを添加することで神経細胞死が有意に抑制された。

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  • Posterior reversible encephalopathy syndromeの臨床像・経過に関する検討

    二宮 格, 金澤 雅人, 赤岩 靖久, 下畑 享良, 西澤 正豊

    臨床神経学   56 ( Suppl. )   S514 - S514   2016.12

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  • 担癌患者における再発性脳梗塞の臨床的特徴

    高橋 哲哉, 赤岩 靖久, 上村 昌寛, 二宮 格, 鳥谷部 真史, 金澤 雅人, 西澤 正豊, 下畑 享良

    臨床神経学   56 ( Suppl. )   S512 - S512   2016.12

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  • 低血糖 低血糖脳症の予後因子に関する検討

    池田 哲彦, 高橋 哲哉, 金澤 雅人, 西澤 正豊, 下畑 享良

    糖尿病合併症   30 ( Suppl.1 )   195 - 195   2016.9

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  • 脳梗塞の病態と新規治療開発の将来像 成長因子プログラニュリンによる脳保護療法

    下畑 享良, 金澤 雅人, 鳥谷部 真史, 小山 美咲, 高橋 哲哉, 西澤 正豊

    脳循環代謝   27 ( 2 )   265 - 269   2016.7

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    DOI： 10.16977/cbfm.27.2_265

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  • PROGRANULIN MEDIATES NEUROVASCULAR PROTECTION VIA MULTIPLE THERAPEUTIC EFFECTS IN EXPERIMENTAL ACUTE ISCHEMIC STROKE

    M. Kanazawa, K. Kawamura, T. Takahashi, M. Miura, Y. Tanaka, M. Koyama, M. Toriyabe, H. Igarashi, T. Nakada, M. Nishizawa, M. Nishihara, T. Shimohata

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   36   579 - 580   2016.6

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  • BLOOD-BRAIN BARRIER DYSFUNCTION CAUSED BY VASCULAR ENDOTHELIAL GROWTH FACTOR UPREGULATION IN RAT MODELS OF SUBACUTE METHYLMERCURY INTOXICATION

    T. Takahashi, M. Fujimura, F. Usuki, M. Koyama, M. Kanazawa, M. Nishizawa, T. Shimohata

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   36   268 - 268   2016.6

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  • MAGNETIC RESONANCE IMAGING FINDINGS IN HYPOGLYCEMIC ENCEPHALOPATHY

    T. Ikeda, T. Takahashi, M. Kanazawa, M. Nishizawa, T. Shimohata

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   36   523 - 524   2016.6

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  • POST-ISCHEMIC EXPRESSION OF AN ANTI-ANGIOGENIC FACTOR VEGF165B AND ITS INHIBITORY EFFECT ON POST-ISCHEMIC ANGIOGENESIS IN RATS.

    M. Ishikawa, T. Takahashi, M. Kanazawa, K. Kawamura, M. Toriyabe, M. Miura, M. Koyama, M. Nishizawa, T. Shimohata

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   36   218 - 219   2016.6

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  • 【脳卒中-新時代の治療を求めて-】 進歩する基礎研究 Progranulin

    金澤 雅人, 川村 邦雄, 高橋 哲哉, 西澤 正豊, 下畑 享良

    日本臨床   74 ( 4 )   579 - 582   2016.4

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  • 多面的保護効果を有するプログラニュリンによる新規脳梗塞治療法の開発

    金澤 雅人

    先進医薬研究振興財団研究成果報告集   2015年度   232 - 233   2016.3

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  • 神経画像アトラス PET-CTにて18F-FDGの集積を認めた頸椎症性脊髄症の1例

    若杉 尚宏, 金澤 雅人, 矢島 隆二, 勝見 敬一, 遠藤 直人, 西澤 正豊

    BRAIN and NERVE: 神経研究の進歩   68 ( 2 )   191 - 193   2016.2

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  • 実験的虚血性脳卒中に対するprogranulinの様々なの治療効果(Multiple therapeutic effects of progranulin on experimental ischemic stroke)

    金澤 雅人, 川村 邦雄, 高橋 哲哉, 田中 良法, 三浦 南, 小山 美咲, 鳥谷部 真史, 五十嵐 博中, 中田 力, 西原 眞杉, 西澤 正豊, 下畑 享良

    臨床神経学   55 ( Suppl. )   S219 - S219   2015.12

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  • 小脳運動失調型進行性核上性麻痺(PSP-C)(Progressive supranuclear palsy with predominant cerebellar ataxia(PSP-C))

    下畑 享良, 金澤 雅人, 高橋 均, 西澤 正豊

    臨床神経学   55 ( Suppl. )   S223 - S223   2015.12

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  • 脳梗塞の病態と新規治療開発の将来像 成長因子プログラニュリンによる脳保護療法

    下畑 享良, 金澤 雅人, 鳥谷部 真史, 小山 美咲, 高橋 哲哉, 西澤 正豊

    脳循環代謝   27 ( 1 )   87 - 87   2015.10

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  • プログラニュリンは、脳虚血後のcaspase-3活性化の抑制により神経細胞を保護する

    鳥谷部 真史, 金澤 雅人, 小山 美咲, 高橋 哲哉, 西澤 正豊, 下畑 享良

    脳循環代謝   27 ( 1 )   128 - 128   2015.10

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  • 脳保護療法とNVU tPA療法後の脳出血防止を目指したトランスレーショナルリサーチ

    下畑 享良, 金澤 雅人, 川村 邦雄, 高橋 哲哉, 西澤 正豊

    脳循環代謝   26 ( 2 )   93 - 97   2015.8

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    DOI： 10.16977/cbfm.26.2_93

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  • 糖尿病の合併症 低血糖脳症の臨床 病態の理解と創薬に向けて

    下畑 享良, 池田 哲彦, 高橋 哲哉, 金澤 雅人, 西澤 正豊

    新潟医学会雑誌   129 ( 7 )   350 - 354   2015.7

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  • Clinicopathological features and diagnostic criteria for progressive supranuclear palsy with predominant cerebellar ataxia

    T. Shimohata, M. Kanazawa, H. Takahashi, M. Nishizawa

    MOVEMENT DISORDERS   30   S329 - S329   2015.6

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  • 血管リモデリング因子を標的としたtPA療法後脳出血合併症の治療

    下畑 享良, 金澤 雅人, 高橋 哲哉, 西澤 正豊

    脳卒中   37 ( 3 )   188 - 193   2015.5

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    DOI： 10.3995/jstroke.37.188

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  • アンギオポエチン1による血栓溶解療法に伴う脳出血合併症の予防効果

    金澤 雅人, 川村 邦雄, 高橋 哲哉, 五十嵐 博中, 中田 力, 西澤 正豊, 下畑 享良

    臨床神経学   54 ( Suppl. )   S39 - S39   2014.12

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  • 低血糖脳症におけるMRI所見の検討

    池田 哲彦, 高橋 哲哉, 金澤 雅人, 西澤 正豊, 下畑 享良

    臨床神経学   54 ( Suppl. )   S45 - S45   2014.12

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  • プログラニュリンは神経細胞保護効果・抗炎症作用をもつ

    三浦 南, 金澤 雅人, 川村 邦雄, 高橋 哲哉, 田中 良法, 小山 美咲, 鳥谷部 真史, 五十嵐 博中, 中田 力, 西原 眞杉, 西澤 正豊, 下畑 享良

    脳循環代謝   26 ( 1 )   219 - 219   2014.11

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  • 脳保護療法とNVU tPA療法後の脳出血抑制を目指したトランスレーショナルリサーチ

    下畑 享良, 金澤 雅人, 川村 邦雄, 高橋 哲哉, 西澤 正豊

    脳循環代謝   26 ( 1 )   77 - 77   2014.11

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  • ラットー過性局所脳虚血モデルにおける血管新生阻害因子VEGF165bの検討

    石川 正典, 高橋 哲哉, 金澤 雅人, 川村 邦雄, 鳥谷部 真史, 三浦 南, 小山 美咲, 西澤 正豊, 下畑 享良

    脳循環代謝   26 ( 1 )   214 - 214   2014.11

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  • 低血糖脳症におけるMRI所見の検討

    池田 哲彦, 高橋 哲哉, 佐藤 晶, 田中 一, 五十嵐 修一, 藤田 信也, 桑原 武夫, 金澤 雅人, 西澤 正豊, 下畑 享良

    脳循環代謝   26 ( 1 )   187 - 187   2014.11

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  • 薬剤師が知っておくべき臓器別画像解析の基礎知識 神経内科学分野 パーキンソニズムの画像診断

    金澤 雅人, 下畑 享良, 西澤 正豊

    医薬ジャーナル   50 ( 9 )   2097 - 2102   2014.9

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    DOI： 10.20837/12014092097

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  • 薬剤師が知っておくべき臓器別画像解析の基礎知識(45)8.神経内科学分野(3)パーキンソニズムの画像診断

    金澤 雅人, 下畑 亨良, 西澤 正豊

    医薬ジャーナル   50 ( 9 )   5 - 10   2014.9

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  • 頭部MRIで特徴的な液面形成(fluid-fluid level)を認めた化膿性脳室炎の2例

    畠山 公大, 金澤 雅人, 北原 真紀子, 久津間 貴和子, 石原 彩子, 田邊 嘉也, 下畑 享良, 西澤 正豊

    NEUROINFECTION   19 ( 2 )   178 - 178   2014.8

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  • 【最新臨床脳卒中学[上]-最新の診断と治療-】 治療戦略を目指した研究 基礎研究 VEGFシグナル阻害による脳出血抑制

    下畑 享良, 金澤 雅人, 川村 邦雄, 高橋 哲哉, 西澤 正豊

    日本臨床   72 ( 増刊5 最新臨床脳卒中学(上) )   412 - 416   2014.7

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  • 神経画像アトラス 複視と眼瞼下垂を呈した多発血管炎性肉芽腫症(ウェゲナー肉芽腫症)の1例

    北原 真紀子, 金澤 雅人, 畠山 公大, 柳村 文寛, 坂上 拓郎, 河内 泉, 西澤 正豊

    BRAIN and NERVE: 神経研究の進歩   66 ( 7 )   880 - 881   2014.7

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  • 腫瘍随伴症候群によるII型呼吸不全で発症した胸腺癌の1例

    佐藤 健, 木村 夕香, 宮尾 浩美, 黒羽 泰子, 小池 亮子, 斎藤 泰晴, 大平 徹郎, 朝川 勝明, 三浦 理, 茂呂 寛, 各務 博, 若杉 尚宏, 金澤 雅人, 河内 泉, 西澤 正豊

    新潟医学会雑誌   128 ( 6 )   280 - 280   2014.6

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  • IVIg治療後に改善を認めた両側横隔神経麻痺の51歳男性例

    若杉 尚宏, 堅田 慎一, 宇津見 宏太, 北原 真紀子, 徳武 孝允, 金澤 雅人, 高橋 哲哉, 西澤 正豊

    臨床神経学   54 ( 3 )   253 - 253   2014.3

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  • 新規脳梗塞治療標的分子としてのプログラニュリンの検討

    金澤 雅人

    循環医学研究年報   ( 6 )   58 - 59   2014.3

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  • 脳血管疾患の急性期、慢性期治療の進歩 tPA療法後の脳出血合併症を抑制する新規脳梗塞治療薬の検討

    金澤 雅人, 下畑 享良, 西澤 正豊

    新潟医学会雑誌   128 ( 1 )   18 - 21   2014.1

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  • Pathognomonic magnetic resonance imaging (MRI) finding of fluid-fluid level in pyogenic ventriculitis: Two case reports

    Masahiro Hatakeyama, Masato Kanazawa, Ayako Ishihara, Yoshinari Tanabe, Takayoshi Shimohata, Masatoyo Nishizawa

    Clinical Neurology   54 ( 9 )   732 - 737   2014

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    DOI： 10.5692/clinicalneurol.54.732

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  • 低血糖脳症におけるグルコース再灌流障害を標的とした新規神経保護薬の検討

    池田 哲彦, 高橋 哲哉, 五十嵐 博中, 金澤 雅人, 伊藤 浩介, 中田 力, 西澤 正豊, 下畑 享良

    臨床神経学   53 ( 12 )   1539 - 1539   2013.12

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  • 小脳性運動失調を伴う進行性核上性麻痺の病初期臨床像の検討

    金澤 雅人, 下畑 享良, 他田 真理, 小野寺 理, 高橋 均, 西澤 正豊

    臨床神経学   53 ( 12 )   1467 - 1467   2013.12

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  • 筋萎縮性側索硬化症の診断における3T頭部MRI拡散強調画像の有用性の検討

    小池 佑佳, 金澤 雅人, 寺島 健史, 下畑 享良, 西澤 正豊

    臨床神経学   53 ( 12 )   1413 - 1413   2013.12

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  • 組織プラスミノゲンアクチベーターによる血栓溶解療法に伴う脳出血合併症に対するアンギオポエチン1の効果

    川村 邦雄, 高橋 哲哉, 金澤 雅人, 五十嵐 博中, 中田 力, 西澤 正豊, 下畑 享良

    脳循環代謝   25 ( 1 )   164 - 164   2013.11

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  • 脳虚血におけるヘパラナーゼによるヘパラン硫酸プロテオグリカンの修飾

    金澤 雅人, Gu Yu-Huan, 長田 高志, Hawkins Brian, 福田 俊一, 中島 元夫, 下畑 享良, 西澤 正豊, del Zoppo Gregory

    脳循環代謝   25 ( 1 )   169 - 169   2013.11

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  • 低血糖脳症における予後因子の検討

    池田 哲彦, 高橋 哲哉, 佐藤 晶, 田中 一, 五十嵐 修一, 藤田 信也, 桑原 武夫, 金澤 雅人, 西澤 正豊, 下畑 享良

    臨床神経学   52 ( 12 )   1458 - 1458   2012.12

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  • 低血糖脳症におけるグルコース再灌流障害による神経細胞障害 新規神経保護薬の検討

    池田 哲彦, 金澤 雅人, 高橋 哲哉, 五十嵐 博中, 西澤 正豊, 下畑 享良

    脳循環代謝   24 ( 1 )   221 - 221   2012.11

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  • 低血糖脳症における予後を予測する因子の検討

    下畑 享良, 池田 哲彦, 高橋 哲哉, 金澤 雅人, 西澤 正豊

    脳循環代謝   24 ( 1 )   220 - 220   2012.11

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  • Basic Neuroscience 神経病理 進行性核上性麻痺における小脳症状と病理

    下畑 享良, 金澤 雅人, 高橋 均, 西澤 正豊

    Annual Review神経   2012   17 - 26   2012.1

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  • 急性脳虚血と組織プラスミノーゲン活性化因子による再灌流は、血管安定化因子アンギオポエチン1の発現を抑制する

    川村 邦雄, 金澤 雅人, 五十嵐 博中, 高橋 哲哉, 中田 力, 西澤 正豊, 下畑 享良

    臨床神経学   51 ( 12 )   1323 - 1323   2011.12

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  • VEGFシグナル阻害はtPAによる血栓溶解療法後の脳出血を抑制する

    下畑 享良, 金澤 雅人, 五十嵐 博中, 高橋 哲哉, 川村 邦雄, 柿田 明美, 高橋 均, 中田 力, 西澤 正豊

    臨床神経学   51 ( 12 )   1323 - 1323   2011.12

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  • VEGFシグナル阻害はtPAによる血栓溶解療法後の脳出血を抑制する

    下畑 享良, 金澤 雅人, 五十嵐 博中, 高橋 哲哉, 川村 邦雄, 柿田 明美, 高橋 均, 中田 力, 西澤 正豊

    脳循環代謝   23 ( 1 )   136 - 136   2011.11

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  • 脳虚血・基礎・メカニズム 急性脳虚血によるTDP-43の生化学的・組織学的変化の検討

    下畑 享良, 金澤 雅人, 柿田 明美, 五十嵐 博中, 高橋 哲哉, 川村 邦雄, 高橋 均, 中田 力, 西澤 正豊

    脳循環代謝   22 ( 2 )   40 - 45   2011.8

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  • 急性脳虚血とtPAによる再灌流は、血管安定化因子アンギオポエチン1の発現を抑制する

    川村 邦雄, 五十嵐 博中, 金澤 雅人, 高橋 哲哉, 中田 力, 西澤 正豊, 下畑 享良

    臨床神経学   50 ( 12 )   1236 - 1236   2010.12

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  • 急性脳虚血によるTDP43の限定分解と神経細胞内局在変化

    下畑 享良, 金澤 雅人, 柿田 明美, 五十嵐 博中, 高橋 哲哉, 高橋 均, 中田 力, 西澤 正豊

    臨床神経学   50 ( 12 )   1171 - 1171   2010.12

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  • 低血糖脳症の予後因子に関する検討

    池田 哲彦, 高橋 哲哉, 金澤 雅人, 西澤 正豊, 下畑 享良

    臨床神経学   50 ( 12 )   1143 - 1143   2010.12

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  • 急性脳虚血とtPAによる再灌流は、血管安定化因子アンギオポエチン1の発現を抑制する

    川村 邦雄, 金澤 雅人, 五十嵐 博中, 高橋 哲哉, 中田 力, 西澤 正豊, 下畑 享良

    脳循環代謝   22 ( 1 )   101 - 101   2010.11

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  • 脳虚血・基礎・メカニズム 急性脳虚血によるTDP-43の生化学的・組織学的変化の検討

    下畑 享良, 金澤 雅人, 柿田 明美, 五十嵐 博中, 高橋 哲哉, 川村 邦雄, 高橋 均, 中田 力, 西澤 正豊

    脳循環代謝   22 ( 1 )   69 - 69   2010.11

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  • ラット中大脳動脈閉塞再灌流モデルにおけるcaspase-3依存性TDP-43切断

    金澤 雅人, 柿田 明美, 五十嵐 博中, 高橋 哲哉, 高橋 均, 西澤 正豊, 中田 力, 下畑 享良

    臨床神経学   49 ( 12 )   1037 - 1037   2009.12

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  • 低血糖脳症の予後因子に関する検討

    池田 哲彦, 高橋 哲哉, 金澤 雅人, 川村 邦雄, 西澤 正豊, 下畑 享良

    脳循環代謝   21 ( 1 )   152 - 152   2009.11

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  • ラット局所脳虚血モデルにおけるcaspase-3依存性TARDNA結合蛋白-43の限定分解

    金澤 雅人

    新潟医学会雑誌   123 ( 11 )   552 - 562   2009.11

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    Other Link： http://search.jamas.or.jp/link/ui/2010145093

  • TDP-43は急性脳虚血により限定分解され、細胞内局在が変化する

    金澤 雅人, 柿田 明美, 五十嵐 博中, 高橋 哲哉, 高橋 均, 中田 力, 西澤 正豊, 下畑 享良

    脳循環代謝   21 ( 1 )   116 - 116   2009.11

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  • 脳虚血に対する神経保護療法の開発を目指して

    下畑 享良, 金澤 雅人, 高橋 哲哉, 西澤 正豊

    新潟医学会雑誌   123 ( 8 )   387 - 393   2009.8

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  • 脳低温療法は局所脳虚血に伴うTDP43の機能障害を抑制する

    下畑 享良, 金澤 雅人, 柿田 明美, 五十嵐 博中, 高橋 哲哉, 高橋 均, 中田 力, 西澤 正豊

    日本脳低温療法学会プログラム・抄録集   12回   45 - 45   2009.7

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  • ポストt-PA時代の神経・血管保護療法

    下畑 享良, 金澤 雅人, 高橋 哲哉, 西澤 正豊

    新潟県医師会報   ( 706 )   2 - 6   2009.1

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  • ラット中大脳動脈塞栓モデルにおける血管内皮細胞のVEGF発現

    金澤 雅人, 五十嵐 博中, 柿田 明美, 高橋 均, 西澤 正豊, 下畑 享良

    臨床神経学   48 ( 12 )   1180 - 1180   2008.12

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  • 抗ガングリオシド抗体陽性末梢神経障害を合併した急性散在性脳脊髄炎の2例

    横関 明子, 河内 泉, 柳川 香織, 川村 邦雄, 横関 明男, 金澤 雅人, 西澤 正豊

    NEUROINFECTION   13 ( 2 )   84 - 84   2008.9

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  • 進行性核上性麻痺の臨床病型の検討

    金澤 雅人, 下畑 享良, 柿田 明美, 豊島 靖子, 他田 真理, 森田 俊, 高橋 均, 西澤 正豊

    臨床神経学   47 ( 12 )   1059 - 1059   2007.12

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  • 自然脱落をきたした大腸粘膜下腫瘍の1例

    塩路 和彦, 富所 隆, 金澤 雅人, 佐藤 知巳, 稲田 勢介, 波田野 徹, 吉川 明

    新潟医学会雑誌   121 ( 1 )   44 - 45   2007.1

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  • 第8番染色体長腕に連鎖する成人発症良性遺伝性舞踏病

    原 賢寿, 下畑 享良, 三瓶 一弘, 河内 泉, 金澤 雅人, 春日 健作, 宮下 哲典, 桑野 良三, 辻 省次, 小野寺 理, 西澤 正豊, 本間 義章

    臨床神経学   46 ( 12 )   1119 - 1119   2006.12

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  • 脳動脈瘤術後に発生した反応性肉芽腫"gauzoma"の79歳女性例

    堅田 慎一, 金澤 雅人, 高橋 俊昭, 田中 惠子, 西澤 正豊

    臨床神経学   46 ( 8 )   590 - 590   2006.8

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  • 脳・脊髄のMRI画像アトラス 仮性外転神経麻痺と垂直性one-and-a-half症候群類似の垂直性注視麻痺を呈した視床中脳梗塞の1例

    金澤 雅人, 三瓶 一弘

    脳と神経   58 ( 1 )   74 - 75   2006.1

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  • 大脳白質病変の重症度とMRAによる頭蓋内血管病変との相関

    金澤 雅人, 三瓶 一弘, 赤岩 靖久, 小野寺 理, 他田 正義, 川村 邦雄, 春日 健作, 高野 弘基, 西澤 正豊

    臨床神経学   45 ( 12 )   1155 - 1155   2005.12

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  • 運動ニューロン疾患との鑑別を要したサルコイドーシスの1例

    小出 隆司, 金澤 雅人, 新保 淳輔, 浦山 勝裕, 八木 伸夫, 土田 昌一, 斎藤 謙, 石黒 英明

    臨床神経学   45 ( 7 )   485 - 489   2005.7

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    50歳女.著明な体重減少,嚥下障害,嗄声を主訴とした.軟口蓋挙上不良,咽頭反射消失,舌辺縁に線維束攣縮があり,肺活量も低下していた.左胸鎖乳突筋の著明な萎縮があり,筋力はMedical Research Council法にて頸前屈2,大臀臀・大腿四頭筋3,腓腹筋・前脛骨筋2レベルに低下しており,握力は右11kg,左13kgであった.運動ニューロン疾患の疑いで入院となり,その際の検査所見にて針筋電図で舌・大腿直筋に明らかな神経原性変化を認め,頸髄,脳MRIでは両側メッケル腔がT2強調画像にて低信号を示した.髄液蛋白高値で,その後細胞数の上昇,血清リゾチームの高値を認め,CTでは両側肺門部リンパ節腫脹を,67Gaシンチグラフィーでは両側肺門部,涙腺,耳下腺に集積を認めた.右斜角筋生検にてサルコイドーシスと診断,プレドニゾロン内服を開始し,その後すべての症状に著明な改善を認めた

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  • LETTERS TO THE EDITOR Parkinson病における睡眠障害の検討

    金澤 雅人, 小出 隆司, 石黒 英明

    神経内科   62 ( 5 )   522 - 522   2005.5

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  • 当院で経験した海綿状血管腫の頭部MRI所見についての検討

    高堂 裕平, 小出 隆司, 金澤 雅人, 西巻 啓一, 皆河 崇志, 石黒 英明

    脳卒中   27 ( 1 )   266 - 266   2005.4

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  • Parkinson病における睡眠障害の検討

    金澤 雅人, 小出 隆司, 加藤 佳子, 廣田 紘一, 石黒 英明

    神経内科   62 ( 3 )   275 - 280   2005.3

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    通院加療中のパーキンソン(PD)病患者38例(平均年齢69.2±7.5歳,罹病期間5.9±4.1年)を対象に,睡眠障害に関するアンケート調査を行った.アンケート結果は,Epworth睡眠スケール(ESS)とPDスケール(PDSS)を用い,睡眠スケールと罹病期間,Hoehn-Yahr重症度,ドパミンアゴニストとの相関について検討した.なお,対照群は20例(平均年齢65.3±6.3歳)である.その結果,PD症例のESS,PDSSは対照群より有意に高く,睡眠スケールとHoehn-Yahr重症度はPDSSと有意な相関を認めた.ドパミンアゴニスト単独内服例ではESS高値で,日中の傾眠傾向を認めた

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  • 急性呼吸不全と昏睡をきたしたWernicke脳症の1例

    金澤 雅人, 小出 隆司, 挽野 素子, 塩田 睦, 石黒 英明

    神経内科   62 ( 2 )   155 - 158   2005.2

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    39歳女.統合失調症で入院中に拒食となり,尿糖が検出され耐糖能障害として経過観察していたところ,呼吸不全と意識レベルの低下が出現した.酸素投与及び果糖含有輸液により症状は改善したが,翌日に眼球が上転し,痛覚刺激への反応なく当科転院した.症状と検査及び画像所見よりWernicke脳症と診断し,サイアミン,マルチビタミン製剤投与及び高カロリー輸液を行った.しかし2型呼吸不全が持続し,気管切開術,末梢神経生検を施行した.入院時に認めたMRIの異常信号は消失し,全身状態も改善した

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  • 小児期の過眠症とオレキシン測定

    菅原 純哉, 金澤 雅人, 宮腰 尚久, 小川 由理子, 阿部 正人, 武村 尊生, 近藤 英明, 神林 崇, 清水 徹男

    臨床神経学   44 ( 12 )   1038 - 1038   2004.12

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  • 過眠症における脳脊髄液中のヒスタミンとオレキシン値

    清水 徹男, 児玉 亨, 金澤 雅人, 宮腰 尚久, 菅原 純哉, 小川 由理子, 近藤 英明, 神林 崇

    臨床神経学   44 ( 12 )   1038 - 1038   2004.12

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  • パーキンソン病における睡眠障害の検討

    金澤 雅人, 小出 隆司, 石黒 英明, 加藤 佳子, 廣田 紘一

    臨床神経学   44 ( 12 )   1051 - 1051   2004.12

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  • MRIでfluid-fluid levelを伴う嚢胞性病変を呈した海綿状血管腫の1例

    金澤 雅人, 西巻 啓一, 小出 隆司, 丸屋 淳, 皆河 崇志, 平安名 常一, 宮内 孝治, 石黒 英明

    脳と神経   56 ( 8 )   695 - 699   2004.8

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    44歳女.初期のMRIにおいて,右側視床にfluid-fluid levelを伴う嚢胞性病変がみられた.その後,腫瘤内部はヘモジデリン沈着と考えられる不均一な信号となり,嚢胞性病変周囲は浮腫と考えられる高信号病変を示した.嚢胞性病変や浮腫は徐々に消失し,最終的に典型的な海綿状血管腫(CA)の所見を示した.CAにはfluid-fluid levelを伴い,嚢胞性病変を呈する症例も存在し,同様の所見を呈する症例ではMRIでの慎重な経過観察が重要だと思われた

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  • A Case of Cystic Cavernous Angioma Accompanied by a Fluid-fluid Level on Magnetic Resonance Imaging

    56 ( 8 )   695 - 699   2004.8

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  • 髄液細胞増多と腱反射亢進を呈したギランバレー症候群(GBS)の一例

    挽野 素子, 小出 隆司, 金澤 雅人, 石黒 英明, 吉野 英

    臨床神経学   44 ( 7 )   479 - 479   2004.7

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  • 脳・脊髄のMRI画像アトラス てんかん重積症例における大脳皮質限局の一過性病変

    金澤 雅人, 挽野 素子, 小出 隆司, 石黒 英明

    脳と神経   56 ( 5 )   434 - 435   2004.5

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  • 全身性筋萎縮に呼吸筋・心筋障害を伴い,慢性に経過する筋炎の3例

    谷 卓, 春日 健作, 金澤 雅人, 茨木 麻衣子, 他田 正義, 佐藤 晶, 田中 惠子, 西澤 正豊, 田中 正美

    神経治療学   21 ( 3 )   300 - 300   2004.5

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  • 無症候性原発性胆汁性肝硬変を合併し,著明な呼吸筋障害を特徴とした慢性筋炎の1例

    春日 健作, 佐藤 晶, 金澤 雅人, 小林 央, 田中 惠子, 西澤 正豊

    臨床神経学   44 ( 4〜5 )   280 - 285   2004.4

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    Language：Japanese   Publisher：(一社)日本神経学会  

    37歳女.5年前から歩行困難,全身に力が入らないことを自覚し,それが増悪したことを契機に精査を行った.傾眠傾向,四肢体幹筋の萎縮と筋力低下を認め,呼吸苦はなかった.しかし,呼吸筋障害があり,著明な低酸素・高炭酸ガス血症を呈し,心筋障害と不整脈を認めた.CKは4207IU/lと著高であり,筋生検にて変性・壊死・再生線維を認めたが,炎症性細胞浸潤は軽度であった.原発性胆汁性肝硬変に特徴的な抗ミトコンドリアM2抗体が陽性であり,原発性胆汁性肝硬変を合併した慢性の筋炎と考えられた.ステロイド内服と4回のパルス療法およびBiPAPにより,改善傾向にある

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  • 運動ニューロン疾患様の症状を呈しステロイド治療にて改善をみたサルコイドーシスの一例

    小出 隆司, 金澤 雅人, 新保 淳輔, 吉川 健二郎, 石黒 英明, 浦山 勝裕, 八木 伸夫, 土田 昌一, 斎藤 謙

    臨床神経学   44 ( 1 )   68 - 68   2004.1

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    Language：Japanese   Publisher：(一社)日本神経学会  

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  • 拡散強調画像による多系統萎縮症の脳幹病変の検討

    金澤 雅人, 下畑 享良, 寺島 健史, 小野寺 理, 田中 恵子, 辻 省次, 岡本 浩一郎, 西澤 正豊

    臨床神経学   43 ( 12 )   1024 - 1024   2003.12

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  • 嚥下障害が初発症状であった全身型破傷風の2例

    金澤 雅人, 石黒 英明, 小野寺 理, 吉川 健二郎, 小出 隆司, 新井 亜希, 長谷川 有香, 中野 亮一, 田中 恵子, 西澤 正豊

    脳と神経   55 ( 11 )   973 - 976   2003.11

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    Language：Japanese   Publisher：(株)医学書院  

    嚥下障害を初発症状とし,全身痙攣を伴わなかった軽症破傷風2例を経験した.症例1:60歳男.著明な開口制限,嚥下障害を認め,破傷風を疑われた.外傷は認めなかったが,開口制限,舌の運動障害,頸部痛を認め,全身型破傷風と診断された.絶飲食,室内暗室とし,破傷風免疫グロブリンを投与し,ペニシリンGの連日投与を開始した.第7病日より症状改善し,第13病日より食事を開始した.筋逸脱酵素が低下し,開口制限,嚥下障害が消失したため,破傷風トキソイドを投与し,退院した.症例2:76歳女.嚥下時に違和感を自覚した.開口制限,舌の運動障害,後頸部痛を認めるため,全身型破傷風を疑い,入院当日に破傷風免疫グロブリンを投与した.投与後症状は改善傾向となり,入院第7病日には飲水可能となった.徐々に食事も摂取でき,開口制限もなくなり,退院した

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  • Two Cases of Generalized Tetanus Presenting with Dysphagia as an Initial Symptom

    55 ( 11 )   973 - 976   2003.11

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  • 多系統萎縮症と自律神経障害 多系統萎縮症における突然死の病態の解明,及び治療法の確立を目指して

    下畑 享良, 金澤 雅人, 寺島 健史, 小野寺 理, 西澤 正豊, 中山 秀章, 篠田 秀夫

    日本自律神経学会総会プログラム・抄録集   56回   64 - 64   2003.10

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    Language：Japanese   Publisher：日本自律神経学会  

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  • 診断・治療に苦慮したCandida albicansによる髄膜炎の一例

    小出 隆司, 新保 淳輔, 金澤 雅人, 加藤 佳子, 石黒 英明

    日赤医学   55 ( 1 )   265 - 265   2003.9

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    Language：Japanese   Publisher：日本赤十字社医学会  

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  • 繰り返す血管造影で検出しえなかった潜在性脊髄硬膜動静脈瘻の一例

    金澤 雅人, 堅田 慎一, 小野寺 理, 田中 恵子, 辻 省次

    臨床神経学   42 ( 10 )   990 - 990   2002.10

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    Language：Japanese   Publisher：(一社)日本神経学会  

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  • 間質性肺炎に著明な気腫性病変を伴った慢性関節リウマチの1例

    金澤 雅人, 佐藤 瑞穂, 森山 寛史, 大井 秀美, 鈴木 栄一, 下条 文武, 磯田 学, 斎藤 正幸, 土田 正則, 梅津 哉

    日本胸部臨床   61 ( 6 )   528 - 536   2002.6

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    Language：Japanese   Publisher：克誠堂出版(株)  

    39歳男.2年前の職場検診の胸部X線像にて両側上肺野の気腫性変化を指摘されていた.今回,多関節痛,朝の手のこわばりと労作時呼吸困難を自覚して来院,胸部CTにて両側肺下葉の間質性病変が認められ,関節症状から慢性関節リウマチ(RA)と診断された.胸腔鏡下生検では間質性肺炎(IP)と気腫性変化が認められ,気道病変は認めなかったが,細気管支領域から肺胞腔内に泡沫細胞の集簇を認めた.これ迄に気道病変を伴わない気腫性変化とRAに伴うIPとの関連についての報告はないが,泡沫細胞の出現がみられたことから,び漫性汎細気管支炎類似の細気管支病変の潜在的な合併の可能性が考えられた.明らかな呼吸器症状を呈さないRA症例においても,早期から呼吸機能検査や胸部CTを含む肺病変の精査を行うことが重要であると考えられた

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    Other Link： http://search.jamas.or.jp/link/ui/2002279145

  • 胸部X線写真で石灰化病変を指摘され,冠動脈造影で冠動脈瘤が確認された川崎病の1例

    田川 実, 金澤 雅人, 佐伯 牧彦, 奥泉 美奈

    新潟医学会雑誌   116 ( 3 )   133 - 133   2002.3

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Awards

  • 学会賞

    2017   日本脳循環代謝学会  

    金澤 雅人

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  • 医学研究奨励賞

    2017   日本医師会  

    金澤 雅人

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  • 草野賞

    2012   日本脳卒中学会・日本心臓財団  

    金澤 雅人

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  • 森山賞

    2022.2   日本脳神経財団   細胞性質変化による脳梗塞に対する細胞療法の確立

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  • Outstanding Author Award for 2020

    2021.10   Neural Regeneration Research, a publication of Chinese Association of Rehabilitation Medicine  

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  • 新潟医師会学術奨励賞

    2019  

    金澤雅人

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  • 岡本研究奨励賞

    2015   成人血管病研究振興財団  

    金澤 雅人

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  • 有壬記念学術奨励賞

    2013  

    金澤 雅人

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  • Significant advance based on animals research award

    2011   American Academy of Neurology  

    Kanazawa Masato

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  • American College of Physicians Evergreen Award

    2007   American College of Physicians  

    Publication Committee, ACP Japan Chapter, American College of Physicians

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Research Projects

  • Development of neuroregeneration therapy mediated by peripheral blood mononuclear cell-derived exosomes through cell modification.

    Grant number：22H03183

    2022.4 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

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  • Development of brain regeneration therapy mediated by peripheral blood mononuclear cell-derived exosomes through cell polarization

    Grant number：23K24442

    2022.4 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

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  • 脳内修復におけるミクログリアによるタウ排泄機序の解明

    Grant number：21K19441

    2021.7 - 2024.3

    System name：科学研究費助成事業

    Research category：挑戦的研究(萌芽)

    Awarding organization：日本学術振興会

    金澤 雅人, 田井中 一貴, 清水 宏, 上野 将紀

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    Grant amount：\6240000 （ Direct Cost: \4800000 、 Indirect Cost：\1440000 ）

    認知症の原因となるタウ蛋白蓄積が生じる能血管障害モデルをもとに，タウ蓄積とその排泄に関して機序の解明を行う．脳血管障害に伴うタウ蛋白蓄積を解明することのみならず，その障害の基盤を解明する研究である．ミクログリアで，タウ蓄積を軽減し，認知機能を改善することができれば，高血圧，糖尿病，高脂血症治療薬を用いて，ミクログリアを保護的に修飾し，タウ排泄促進するかを検討する．これにて，ドラッグ・リポジショニングの応用が可能である．さらに，異常蛋白蓄積による神経変性疾患にも応用可能な提案であり，他の蛋白排泄機序の解明につながり，他の神経疾患研究にも展開する．

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  • Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.

    Grant number：19H01043

    2019.4 - 2022.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (A)

    Awarding organization：Japan Society for the Promotion of Science

    ONODERA OSMAU

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    Grant amount：\45500000 （ Direct Cost: \35000000 、 Indirect Cost：\10500000 ）

    We found that HTRA1-deficient mice serve as a model animal for age-related changes similar to those in small cerebral blood vessels. Quantitative DIA proteomics and GO analysis revealed that the main abnormality is in the extracellular matrix and matrizomes, with fibronectin as a hub protein as a starting point. Accumulation of fibronectin is a common phenomenon in age-related cerebral microvascular changes. We found that candesartan suppressed this change. In addition, they found that candesartan also reduced cerebral blood flow and vasodilatability. In addition, they found that treatment with candesartan improved the vasodilatory changes. The results clearly indicate that extracellular proteostasis plays a major role in the homeostasis of proteins in the brain.

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  • Peripheral blood-derived mononuclear cells preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic stroke

    Grant number：18K07493

    2018.4 - 2022.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Kanazawa Masato

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    When exogenous peripheral blood mononuclear cells preconditioned by oxygen glucose-deprivation (OGD) were administered to rats with post-ischemic sequelae, angiogenesis and neuronal axonal outgrowth were confirmed, and motor-sensory functions were significantly improved 21 days after cell administration (28 days after ischemia).
    We developed a bag that can perform OGD stimulation in a closed system for clinical application, and verified the effect of OGD stimulation on human-derived cells. We also confirmed that the number of SSEA3-positive mononuclear cells, a pluripotent stem cell marker, increased after stimulation. We also showed that cells stimulated with this bag also showed therapeutic effects, and we have applied for a patent.

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  • Novel treatment using microglia preconditioned by oxygen glucose deprivation against cerebral hemorrhage

    Grant number：18K07496

    2018.4 - 2021.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    SHIMOHATA TAKAYOSHI

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    In this study, we examined the changes in the properties of peripheral blood mononuclear cells (PBMCs), a precursor of microglia, by stimulating them with OGD, and found that OGD-PBMCs secrete vascular remodeling factors such as vascular endothelial growth factor (VEGF) and TGF-β. On the other hand, when OGD-PBMCs were administered transarterially on day 7 of ischemia in an animal model, they were found in the brain parenchyma and improved prognosis on day 28. Furthermore, we found that OGD-PBMCs can induce SSEA3-positive cells. In addition, OGD-PBMCs promoted migration through the blood-brain barrier. Furthermore, OGD-PBMCs promoted angiogenesis and neuronal axon extension. Finally, we developed an OGD device for clinical trials.

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  • The establishment of therapeutic strategies of microglial transplantation against chronic ischemic stroke

    Grant number：15K19478

    2015.4 - 2018.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    Kanazawa Masato, Shimohata Takayoshi, Takahashi Tetsuya

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    We confirmed primary microglia under oxygen-glucose deprivation (OGD) conditions like mild ischemia polar to protective M2 microglia. We found that intraarterial administration of OGD microglia promoted functional recovery via angiogenesis in the border area within the ischemic core as well as axonal outgrowth in the ischemic penumbra by remodeling factors such as vascular endothelial growth factor (VEGF) and transforming growth factor at 28 days after ischemia. Furthermore, we could isolated primary microglia from adult rats under cerebral ischemia. We also demonstrated that OGD condition prompted more secretion of VEGF than hypoxia or glucose-deprivation stimulus only. In conclusion, intravascular administration of M2 microglia preconditioned by optimal OGD might be a novel therapeutic strategy against ischemic stroke.

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  • Analysis of progranulin as novel therapeutic target against ischemic stroke

    Grant number：26430066

    2014.4 - 2017.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    SHIMOHATA Takayoshi, KANAZAWA Masato

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    Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）

    We observed that progranulin (PGRN) could protect against acute focal cerebral ischemia by variety of mechanisms, which we call "brain protection", including neuroprotection in part by inhibition of cytoplasmic redistribution of TDP-43 using PGRN knock-out mice, suppression of neuroinflammation via anti-inflammatory interleukin-10 in microglia, and attenuation of blood-brain barrier disruption via vascular endothelial growth factor. We also demonstrated the therapeutic potential of PGRN against acute focal cerebral ischemia using a rat autologous thromboembolic model with delayed tissue plasminogen activator treatment. Intravenously administered recombinant PGRN significantly reduced volumes of cerebral infarct and edema, suppressed hemorrhagic transformation, and improved motor outcome. PGRN may be a novel therapeutic target that provides brain protection such as vascular protection, anti-neuroinflammation, and neuroprotection.

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  • Vasoprotective protein Angiopoietin-1 is a novel therpeutic target molecule for cerebral ischemia

    Grant number：25430063

    2013.4 - 2016.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    TAKAHASHI Tetsuya, SHIMOHATA Takayoshi, KANAZAWA Masato

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    Grant amount：\5460000 （ Direct Cost: \4200000 、 Indirect Cost：\1260000 ）

    An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier (BBB) disruption after focal cerebral ischemia. We hypothesized that administering Ang1 might attenuate hemorrhagic transformation and cerebral edema after tissue plasminogen activator (tPA) treatment by stabilizing blood vessels and inhibiting hyperpermeability. We used the rat thromboembolic focal cerebral ischemia model treated with tPA after ischemia with recombinant Ang1 protein or vehicle. Ang1 expression levels and Ang1-positive vessel densities on the ischemic side of the cerebral cortex were decreased after ischemia. Administration of recombinant Ang1 protein showed that the suppression of hemorrhagic transformation and less cerebral edema, as compared to administering vehicle protein. In conclusion, Ang1 might be a promising target molecule for developing vasoprotective therapies for controlling hemorrhagic transformation and cerebral edema after tPA treatment.

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  • Tissue remodeling by microglia for a novel therapeutic strategy in chronic cerebral ischemia

    Grant number：25860702

    2013.4 - 2015.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    KANAZAWA Masato, SHIMOHATA Takayoshi, TAKAHASHI Tetsuya

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    Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）

    We evaluated the cellular proliferation in rats subjected to focal cerebral ischemia. We observed proliferated endothelial cells and pericytes, and increased numbers of microglia even though in the ischemic core, and angiogensis in the peripheral zone of the ischemic core at 7 and 14 days after cerebral ischemia. In vitro primary cells revealed that vascular endothelial growth factor was secreted from the microglia after oxygen-glucose deprivation (OGD). Protective growth factor progranulin was also secreted from the neuronal cells and microglia after OGD. Finally, we demonstrated the therapeutic potential of microglia against chronic focal cerebral ischemia. Seven days after ischemia, intraarterial injection of microglia stimulated OGD via carotid artery improved motor outcome compared to injections of astrocytes and phosphate buffer solution. Microglial transplantation may be a novel therapeutic strategy that provides tissue remodeling after chronic cerebral ischemia.

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Teaching Experience

  • 医学序説 I

    2023
    Institution name：新潟大学

  • 医学序説 II

    2022
    Institution name：新潟大学