Updated on 2026/04/30

写真a

 
SUGIYAMA Sayaka
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine Professor
Title
Professor
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Degree

  • 博士(医学) ( 2001.3   東北大学 )

Research Interests

  • 臨界期

  • 包括脳ネットワーク

  • 可塑性

  • 眼優位性

  • homeoprotein

  • GABA

  • 視覚野

  • Otx2

Research Areas

  • Life Science / Neuroscience-general

Research History (researchmap)

  • Niigata University   Division of Developmental Physiology, Graduate School of Medical and Dental Sciences   Professor

    2022.4

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  • Niigata University

    2014.4 - 2022.3

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  • 新潟大学 医歯学系 神経発達研究室   テニュアトラック准教授(PI)

    2009.10 - 2014.3

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  • Harvard University

    2006 - 2009

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  • RIKEN   Researcher

    2005

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  • RIKEN

    2002 - 2005

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  • 東北大学加齢研 分子神経研究分野   JSPS特別研究員

    1999 - 2002

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Research History

  • Niigata University   Regenerative and Transplant Medicine, Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences   Professor

    2022.4

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Professor

    2022.4

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine   Associate Professor

    2014.4 - 2022.3

  • Niigata University   Headquarters for Strategy and Planning Office for Promoting the Cultivation of Young Researchers   Associate Professor

    2009.10 - 2014.3

Professional Memberships

Committee Memberships

  • 日本生理学会   評議員  

    2023   

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  • 日本神経科学学会   電子ジャーナル検討委員  

    2015 - 2016   

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    Committee type:Academic society

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  • 日本神経科学学会   ダイバーシティ対応委員  

    2013.6   

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    Committee type:Academic society

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Papers

  • Coactosin Promotes F-Actin Protrusion in Growth Cones Under Cofilin-Related Signaling Pathway Reviewed

    Xubin Hou, Motohiro Nozumi, Harukazu Nakamura, Michihiro Igarashi, Sayaka Sugiyama

    Frontiers in Cell and Developmental Biology   9   2021.6

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    During brain development, axon outgrowth and its subsequent pathfinding are reliant on a highly motile growth cone located at the tip of the axon. Actin polymerization that is regulated by actin-depolymerizing factors homology (ADF-H) domain-containing family drives the formation of lamellipodia and filopodia at the leading edge of growth cones for axon guidance. However, the precise localization and function of ADF-H domain-containing proteins involved in axon extension and retraction remain unclear. We have previously shown that transcripts and proteins of coactosin-like protein 1 (COTL1), an ADF-H domain-containing protein, are observed in neurites and axons in chick embryos. Coactosin overexpression analysis revealed that this protein was localized to axonal growth cones and involved in axon extension in the midbrain. We further examined the specific distribution of coactosin and cofilin within the growth cone using superresolution microscopy, structured illumination microscopy, which overcomes the optical diffraction limitation and is suitable to the analysis of cellular dynamic movements. We found that coactosin was tightly associated with F-actin bundles at the growth cones and that coactosin overexpression promoted the expansion of lamellipodia and extension of growth cones. Coactosin knockdown in oculomotor neurons resulted in an increase in the levels of the inactive, phosphorylated form of cofilin and dysregulation of actin polymerization and axonal elongation, which suggests that coactosin promoted axonal growth in a cofilin-dependent manner. Indeed, the application of a dominant-negative form of LIMK1, a downstream effector of GTPases, reversed the effect of coactosin knockdown on axonal growth by enhancing cofilin activity. Combined, our results indicate that coactosin functions promote the assembly of protrusive actin filament arrays at the leading edge for growth cone motility.

    DOI: 10.3389/fcell.2021.660349

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  • Single-Cell Visualization Deep in Brain Structures by Gene Transfer Reviewed

    Sayaka Sugiyama, Junko Sugi, Tomoya Iijima, Xubin Hou

    Frontiers in Neural Circuits   14   2020.11

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    DOI: 10.3389/fncir.2020.586043

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  • Reciprocal connectivity between secondary auditory cortical field and amygdala in mice. Reviewed International journal

    Tsukano H, Hou X, Horie M, Kitaura H, Nishio N, Hishida R, Takahashi K, Kakita A, Takebayashi H, Sugiyama S, Shibuki K

    Scientific reports   9 ( 1 )   19610 - 19610   2019.12

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    Recent studies have examined the feedback pathway from the amygdala to the auditory cortex in conjunction with the feedforward pathway from the auditory cortex to the amygdala. However, these connections have not been fully characterized. Here, to visualize the comprehensive connectivity between the auditory cortex and amygdala, we injected cholera toxin subunit b (CTB), a bidirectional tracer, into multiple subfields in the mouse auditory cortex after identifying the location of these subfields using flavoprotein fluorescence imaging. After injecting CTB into the secondary auditory field (A2), we found densely innervated CTB-positive axon terminals that were mainly located in the lateral amygdala (La), and slight innervations in other divisions such as the basal amygdala. Moreover, we found a large number of retrogradely-stained CTB-positive neurons in La after injecting CTB into A2. When injecting CTB into the primary auditory cortex (A1), a small number of CTB-positive neurons and axons were visualized in the amygdala. Finally, we found a near complete absence of connections between the other auditory cortical fields and the amygdala. These data suggest that reciprocal connections between A2 and La are main conduits for communication between the auditory cortex and amygdala in mice.

    DOI: 10.1038/s41598-019-56092-9

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  • Experience-dependent transcriptional regulation in juvenile brain development. Reviewed

    Sakai A, Sugiyama S

    Development, growth & differentiation   60 ( 8 )   473 - 482   2018.10

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    Authorship:Corresponding author  

    DOI: 10.1111/dgd.12571

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  • Roles of CSGalNAcT1, a key enzyme in regulation of CS synthesis, in neuronal regeneration and plasticity. Reviewed International journal

    Michihiro Igarashi, Kosei Takeuchi, Sayaka Sugiyama

    Neurochemistry international   119   77 - 83   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    Chondroitin sulfate (CS) is a sulfated glycosaminoglycan composed of a long chain of repeating disaccharide units that are attached to core proteins, resulting in CS proteoglycans (CSPGs). In the mature brain, CS is concentrated in perineuronal nets (PNNs), which are extracellular structures that surround synapses and regulate synaptic plasticity. In addition, CS is rapidly synthesized after CNS injury to create a physical and chemical barrier that inhibits axon growth. Most previous studies used a bacterial CS-degrading enzyme to investigate the physiological roles of CS. Recent studies have shown that CS is synthesized by more than 15 enzymes, all of which have been characterized in vitro. Here we focus on one of those enzymes, CSGalNAcT1 (T1). We produced T1 knockout mice (KO), which show extensive axon regeneration following spinal cord injury, as well as the loss of onset of ocular dominance plasticity. These results from T1KO mice suggest important roles for extracellular CS in the brain regarding neuronal plasticity and axon regeneration.

    DOI: 10.1016/j.neuint.2017.10.001

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  • Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex Reviewed

    Xubin Hou, Nozomu Yoshioka, Hiroaki Tsukano, Akiko Sakai, Shinji Miyata, Yumi Watanabe, Yuchio Yanagawa, Kenji Sakimura, Kosei Takeuchi, Hiroshi Kitagawa, Takao K. Hensch, Katsuei Shibuki, Michihiro Igarashi, Sayaka Sugiyama

    SCIENTIFIC REPORTS   7 ( 1 )   12646   2017.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-04007-x

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  • Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex Reviewed

    Akiko Sakai, Ryuichiro Nakato, Yiwei Ling, Xubin Hou, Norikazu Hara, Tomoya Iijima, Yuchio Yanagawa, Ryozo Kuwano, Shujiro Okuda, Katsuhiko Shirahige, Sayaka Sugiyama

    FRONTIERS IN NEUROSCIENCE   11   2017.5

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fnins.2017.00307

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  • Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex Reviewed

    Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    NATURE COMMUNICATIONS   7   11827   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms11827

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  • Coactosin accelerates cell dynamism by promoting actin polymerization Reviewed

    Xubin Hou, Tatsuya Katahira, Kazumasa Ohashi, Kensaku Mizuno, Sayaka Sugiyama, Harukazu Nakamura

    DEVELOPMENTAL BIOLOGY   379 ( 1 )   53 - 63   2013.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ydbio.2013.04.006

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  • Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex Reviewed

    Marine Beurdeley, Julien Spatazza, Henry H. C. Lee, Sayaka Sugiyama, Clemence Bernard, Ariel A. Di Nardo, Takao K. Hensch, Alain Prochiantz

    JOURNAL OF NEUROSCIENCE   32 ( 27 )   9429 - 9437   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.0394-12.2012

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  • From brain formation to plasticity: Insights on Otx2 homeoprotein Reviewed

    Sayaka Sugiyama, Alain Prochiantz, Takao K. Hensch

    DEVELOPMENT GROWTH & DIFFERENTIATION   51 ( 3 )   369 - 377   2009.4

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    Authorship:Lead author, Corresponding author   Language:English  

    DOI: 10.1111/j.1440-169X.2009.01093.x

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  • Clonal and widespread gene transfer by proviral electroporation for analysis of brain laminar formation Reviewed

    Sayaka Sugiyama, Harukazu Nakamura

    Electroporation and Sonoporation in Developmental Biology   117 - 127   2009

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    Authorship:Lead author   Language:English   Publishing type:Part of collection (book)   Publisher:Springer Japan  

    DOI: 10.1007/978-4-431-09427-2_12

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  • Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity Reviewed

    Sayaka Sugiyama, Ariel A. Di Nardo, Shinichi Aizawa, Isao Matsuo, Michel Volovitch, Alain Prochiantz, Takao K. Hensch

    CELL   134 ( 3 )   508 - 520   2008.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cell.2008.05.054

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  • Polarity and laminar formation of the optic tectum in relation to retinal projection Reviewed

    H Nakamura, S Sugiyama

    JOURNAL OF NEUROBIOLOGY   59 ( 1 )   48 - 56   2004.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/neu.10339

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  • The role of Grg4 in tectal laminar formation Reviewed

    S Sugiyama, H Nakamura

    DEVELOPMENT   130 ( 3 )   451 - 462   2003.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/dev.00232

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  • Antagonizing activity of chick Grg4 against tectum-organizing activity Reviewed

    S Sugiyama, J Funahashi, H Nakamura

    DEVELOPMENTAL BIOLOGY   221 ( 1 )   168 - 180   2000.5

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/dbio.2000.9643

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  • Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum Reviewed

    T Katahira, T Sato, S Sugiyama, T Okafuji, Araki, I, J Funahashi, H Nakamura

    MECHANISMS OF DEVELOPMENT   91 ( 1-2 )   43 - 52   2000.3

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    DOI: 10.1016/S0925-4773(99)00262-2

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  • Apical ectodermal ridge induction by the transplantation of En-1-overexpressing ectoderm in chick limb bud Reviewed

    M Tanaka, Y Shigetani, S Sugiyama, K Tamura, H Nakamura, H Ide

    DEVELOPMENT GROWTH & DIFFERENTIATION   40 ( 4 )   423 - 429   1998.8

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    DOI: 10.1046/j.1440-169X.1998.t01-2-00007.x

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  • Crossregulation between En-2 and Wnt-1 in chick tectal development Reviewed

    S Sugiyama, J Funahashi, J Kitajewski, H Nakamura

    DEVELOPMENT GROWTH & DIFFERENTIATION   40 ( 2 )   157 - 166   1998.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1440-169X.1998.00005.x

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Books

  • カンデル神経科学

    Kandel, Eric R., Koester, John, Mack, Sarah, Siegelbaum, Steven, (監修)宮下, 保司, (監訳)岡野, 栄之, 神谷, 之康, 合田, 裕紀子, 加藤, 総夫, 藤田, 一郎, 伊佐, 正, 定藤, 規弘, 大隅, 典子, 井ノ口, 馨, 笠井, 清登, (訳)杉山, 清佳 他84名(第49章 経験とシナプス結合の精緻化)

    メディカル・サイエンス・インターナショナル  2022.9  ( ISBN:9784815730550

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    Total pages:xlviii, 1653p   Language:Japanese

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  • 分子脳科学: 分子から脳機能と心に迫る (DOJIN BIOSCIENCE)

    杉山清佳, 三品 昌美( Role: Contributor ,  第23章 脳発達の臨界期)

    化学同人  2015.4  ( ISBN:4759815198

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    Total pages:291  

    ASIN

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  • Electroporation and Sonoporation in Developmental Bilogy

    Sugiyama S, Nakamura H, Nakamura Harukazu( Role: Contributor ,  Clonal and widespread gene transfer by proviral electroporation for analysis of brain laminar formation)

    Springer  2009.4  ( ISBN:4431094261

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    Total pages:364  

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MISC

  • 経験に応じて回路に個性が生まれるメカニズム Invited

    杉山清佳

    新潟医学会雑誌   137   295 - 299   2023

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  • 子どもの臨界期と回路の個性化 Invited

    杉山清佳

    新潟県医師会報   873   1 - 6   2022

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  • 弱視の臨界期に関する最近の知見

    杉山清佳, 侯旭濱

    眼科   61 ( 1 )   2019.1

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  • ドーパミン作動性細胞に発現するOtx2の恐怖記憶における役割

    飯島 友也, 杉山 清佳

    新潟医学会雑誌   132 ( 2 )   49 - 59   2018.2

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    Language:Japanese   Publisher:新潟医学会  

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  • Mechanism of critical period : understanding brain plasticity in childhood

    酒井 晶子, 杉山 清佳

    生体の科学   68 ( 1 )   54 - 58   2017.1

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    Language:Japanese   Publisher:金原一郎記念医学医療振興財団 ; 1949-  

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  • 臨界期

    杉山清佳

    脳科学辞典 DOI:10.14931/bsd.6426   2015

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  • 【弱視研究の最先端】 弱視の臨界期メカニズム ホメオ蛋白質と糖鎖の新しい役割

    杉山 清佳

    神経眼科   29 ( 4 )   396 - 403   2012.12

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    Language:Japanese   Publisher:日本神経眼科学会  

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  • New Insights for Otx2 Homeoprotein in Cerebral Plasticity

    Sugiyama Sayaka

    新潟医学会雑誌   125 ( 4 )   175 - 179   2011.4

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    Language:Japanese   Publisher:新潟医学会  

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  • Isthmus organizer: regulation of cellebelar and tectal development

    53 ( 4 )   373 - 378   2008.3

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  • 中脳領域の特異化 (特集 脳の発達に関与する分子機構)

    杉山清佳, 仲村春和

    生体の科学   52 ( 3 )   177 - 181   2001.5

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    Language:Japanese   Publisher:金原一郎記念医学医療振興財団  

    DOI: 10.11477/mf.2425902265

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  • 【小児神経学の最近の話題】 神経系の分化と発達 脳の形態形成

    杉山 清佳, 仲村 春和

    Clinical Neuroscience   17 ( 3 )   254 - 257   1999.3

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    Language:Japanese   Publisher:(株)中外医学社  

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  • ニワトリ胚中脳後側に強く発現する遺伝子Wnt-1とEnの相互作用

    杉山 清佳

    加齢医学研究所雑誌   48 ( 2 )   115 - 115   1997.3

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    Language:Japanese   Publisher:東北大学加齢医学研究所  

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  • ニワトリ胚中脳の吻尾極性に関わる遺伝子カスケードの解析

    舟橋 淳一, 杉山 清佳, 原 知永, 仲村 春和

    日本分子生物学会年会プログラム・講演要旨集   19   673 - 673   1996.8

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Presentations

  • こどもの脳の柔軟性~個性と向き合う(入澤彩記念女性生理学者奨励賞 受賞講演)

    杉山清佳

    APPW2025  2025 

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  • 視覚優位をもたらす回路と機能

    杉山清佳

    第48回日本神経科学大会サテライトシンポジウム(脳神経回路の形成・動作と制御2025)  2025 

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  • 自分軸の研究を歩むための一歩(Meet the Professor ランチョン講演)

    杉山清佳

    APPW2025  2025 

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  • Visual experience specifies primary dendrites in cortical interneurons for perception

    Sayaka Sugiyama

    Partnership Symposium between DANDRITE (Aarhus University, Denmark) and BRI (Niigata University)  2023 

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  • 女性研究者上位職が育成されリーダーとして活躍するためには?

    杉山清佳

    順天堂大学ダイバーシティ推進室企画セミナー  2023 

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  • こどもの脳が柔軟に成長する仕組み~経験依存の回路形成~

    杉山清佳

    第18回名古屋大学ホームカミングデイ 環境医学研究所市民公開講座  2022 

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  • Visual experience specifies primary dendrites in cortical interneurons during the critical period

    Sayaka Sugiyama

    The 5th Spring Meeting of Neural Development, Tohoku University  2022 

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  • 弱視の臨界期の分子メカニズム

    杉山清佳

    第122回日本眼科学会総会  2018 

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  • Dendritic organization of cortical interneurons in anticipation of postnatal plasticity

    Sayaka Sugiyama

    The 41th Annual Meeting of the Japan Neuroscience Society  2018 

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    Presentation type:Symposium, workshop panel (public)  

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  • 視覚経験による個性的回路の創出機構

    杉山清佳

    次世代脳プロジェクト 冬のシンポジウム  2017 

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  • Transcriptional regulation of homeoprotein in postnatal cortical plasticity.

    Sayaka Sugiyama

    The 40th Annual Meeting of the Japan Neuroscience Society  2017 

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  • Experience-dependent maturation of inhibitory circuits in ocular dominance plasticity.

    Sayaka Sugiyama

    The 39th Annual Meeting of the Japan Neuroscience Society.  2016 

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  • Ocular dominance plasticity regulated by Otx2-inducible molecules.

    Sayaka Sugiyama

    The 58th Annual Meeting of the Japan Society for Neurochemistry  2015 

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  • Inhibitory maturation regulates the critical period plasticity for binocular vision.

    Sayaka Sugiyama

    The 120th Annual Meeting of the Japanese Association of Anatomists  2015 

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  • コンドロイチン硫酸による量依存的な臨界期制御

    杉山清佳

    第38回日本分子生物学会年会  2015 

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  • コンドロイチン硫酸とホメオ蛋白質による臨界期制御

    杉山清佳

    第87回日本生化学会大会  2014 

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  • 臨界期のメカニズム-経験依存の回路形成-

    杉山清佳

    第38回峠の会(形態学セミナー)  2014 

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  • コンドロイチン硫酸による抑制性ニューロンの機能発達と臨界期制御

    杉山清佳

    第57回日本神経化学会大会  2014 

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  • 臨界期の時期を制御する分子たち

    杉山清佳

    第18回視覚科学フォーラム 特別企画シンポジウム  2014 

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  • 臨界期の分子メカニズム-モデル動物からの知見-

    杉山清佳

    第69回日本弱視斜視学会総会  2013 

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  • 臨界期におけるホメオ蛋白質の新しい役割

    杉山清佳

    東北大学脳センターシンポジューム  2013 

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  • Otx2 binding to sugar chains regulates plasticity in mouse visual cortex.

    Sayaka Sugiyama

    NIG workshop: Circuit construction in the mammalian cerebral cortex  2012 

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  • Interaction of Otx2 and glycosaminoglycan regulates cortical plasticity for binocular vision.

    Sayaka Sugiyama

    The 35th Annual Meeting of the Japan Neuroscience Society  2012 

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Awards

  • 入澤彩記念女性生理学者奨励賞

    2025.3   日本生理学会  

    杉山清佳

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  • 女性研究者サイエンスグラント賞

    2018.7   資生堂  

    杉山清佳

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  • 第一回女性研究者賞

    2013.11   ソロプチミスト日本財団  

    杉山清佳

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Teaching Experience (researchmap)

  • 人体の構造と機能I(解剖総論・肉眼解剖学)

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  • 人体の構造と機能I(生理学)

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  • 先端医科学研究概説

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  • 人体の構造と機能II(神経解剖学・実習)

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  • 医学研究実習

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  • 細胞生物学

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  • 脳と心の医科学

    Institution name:新潟大学大学院

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  • 人体の構造と機能II(生理学・実習)(新潟大学)

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Teaching Experience

  • 神経発達学演習

    2026
    Institution name:新潟大学

  • 発達生理学演習

    2026
    Institution name:新潟大学

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    Institution name:新潟大学

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    Institution name:新潟大学

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    Institution name:新潟大学

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    Institution name:新潟大学

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    Institution name:新潟大学

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    Institution name:新潟大学

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    Institution name:新潟大学

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