Updated on 2024/04/20
博士（医学） ( 2010.3 新潟大学 )
Life Science / Forensics medicine
Niigata University Institute of Medicine and Dentistry, Academic Assembly Assistant Professor
2022.7
Niigata University Community Preventive Medicine, Community Disease Control, Graduate School of Medical and Dental Sciences Assistant Professor
2022.7
Niigata University Graduate School of Medical and Dental Sciences Specially Appointed Assistant Professor
2017.9 - 2022.6
Niigata University Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Molecular Genetics Specially Appointed Assistant Professor
2010.4 - 2012.3
Dentist
Bcl11b prevents the intrathymic development of innate CD8 T cells in a cell intrinsic manner. Reviewed
Hirose S, Touma M, Go R, Katsuragi Y, Sakuraba Y, Gondo Y, Abe M, Sakimura K, Mishima Y, Kominami R
International immunology 27 ( 4 ) 205 - 215 2015.4
Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele. Reviewed
Go R, Hirose S, Katsuragi Y, Obata M, Abe M, Mishima Y, Sakimura K, Kominami R
Cancer science 104 ( 8 ) 1009 - 1016 2013.8
Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis. Reviewed
Go R, Takizawa K, Hirose S, Katsuragi Y, Aoyagi Y, Mishima Y, Kominami R
Leukemia research 36 ( 8 ) 1035 - 1040 2012.8
Bcl11b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice. Reviewed
Go R, Hirose S, Morita S, Yamamoto T, Katsuragi Y, Mishima Y, Kominami R
Cancer science 101 ( 6 ) 1347 - 1353 2010.6
Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus. Reviewed
Yamamoto T, Morita S, Go R, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R
International journal of radiation oncology, biology, physics 77 ( 1 ) 235 - 243 2010.5
Identification of cells of origin in lymphomas and the target of γ-radiation
Grant number：23710067
2011 - 2012
System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Research category：Grant-in-Aid for Young Scientists (B)
Awarding organization：Japan Society for the Promotion of Science
GO Rieka
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
Cell of origin in γ-radiation induced mouse thymic lymphomas remains obscure. In this study, we generated mouse models in which loss of one Bcl11b allele occurs in thymocytes at different developmental stages and examined expansion and differentiation of premalignant thymocytes after irradiation. We showed that thymocytes at the immature stage were cells of origin and premalignant thymocytes retained the capacity to proliferate and differentiate. Also, loss of Bcl11b allele in thymocytes led to impaired cell cycle arrest at S phase after irradiation, suggesting that the impairment contributes to the development of the premalignant thymocytes.
医学論文を読む(ジャーナルクラブ)A
医療と法
歯科法医学
特別授業 歯科法医学
