研究者詳細 - 植木　智志

論文 - 植木　智志

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植木智志

新潟医学会雑誌 119 ( 8 ) 474 - 480 2005年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：新潟大学

【目的】視神経疾患の診療において軸索機能を評価するために磁気共鳴画像法(MRI)は今や必須と言える検査法であるが,現在用いられている撮像法では定量性に乏しいという欠点が存在する.本研究は視神経の軸索機能を,超高磁場拡散強調MRIを用いて定量的に評価することを目的とした.【方法】片側急性視神経炎患者5名と片側慢性視神経症患者6名と正常被験者16名を対象とした.それぞれの被験者の両側視神経に設定した関心領域でtrace値(神経線維の微細構造を含めた軸索機能の変化を示す)を測定した.【結果】片側急性視神経炎患者の患側視神経のtrace値は正常被験者に比べ有意に低かった.一方,片側慢性視神経症患者の患側視神経のtrace値は健側視神経および正常被験者に比べ有意に高かった.【結論】患者の視神経において,病態の相違がtrace値の変化の相違として観察された.これらの結果は軸索炎症の指標および軸索変性の指標が非侵貧的に,かつ定量的に測定可能であることを示している.超高磁場拡散強調MRHこよりtrace値を測定することで,視神経の軸索機能を定量的に評価することが可能となると考えられ,臨床的に有用と思われる.

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その他リンク： http://hdl.handle.net/10191/3485

[Multifocal visually evoked responses in two children with optic neuritis] 査読

Hatase T, Hasegawa S, Tanimoto N, Miki A, Ueki S, Usui T, Takaki M, Abe H

Nihon Ganka Gakkai Zasshi 109 ( 8 ) 497 - 503 2005年8月

Night blindness with depolarizing pattern of ON/OFF response in electroretinogram: A case report 査読

T Usui, N Tanimoto, S Ueki, A Miki, M Takagi, S Hasegawa, H Abe

DOCUMENTA OPHTHALMOLOGICA 111 ( 1 ) 15 - 21 2005年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

Purpose: To present a patient who has night blindness with a depolarizing pattern of ON/OFF response by electroretinography (ERG). Case: A 43-year-old woman had had night blindness and poorly corrected visual acuity since childhood. Parental consanguinity was noted. The patient had suffered from mental retardation, epilepsy, and mild cerebellar ataxia. Corrected visual acuity was 20/30 in the right eye and 20/25 in the left. Goldmann perimetry showed no scotoma but slight depression with internal isoptors. No evidence for rod activity was observed by Goldmann-Weekers adaptometry. The ocular fundi appeared normal. Methods: Conventional full-field ERGs to scotopic (dim and bright flash) and photopic (bright flash and flicker) stimuli were recorded. Photopic ERG responses to long flash stimulation (200 ms) were also examined. Results: The scotopic responses to dim flash were non-recordable, while those to bright flash were severely reduced. The photopic responses to bright flash were decreased. The amplitudes of flicker responses also were significantly decreased, and the implicit times of those responses were prolonged. Although the amplitudes of a- and d-waves to long flash stimulation were reduced, those of the b-wave were within normal range. The implicit times of a-, b- and d-waves were significantly prolonged. The patient showed a normal rise for the photopic b-wave but lacked a normal failing slope after the b-wave peak. An OFF-response late-negativity was also noted. Conclusions: The abnormal ON/OFF response found in the patient could be diagnosed as depolarizing pattern, characterized by elevation of the plateau to a positive potential above the prestimulus baseline. Since the ERG waveforms and clinical features found in our patient were different from those in previous reports, her ERG findings might reflect another retinal physiological mechanism.

DOI： 10.1007/s10633-005-3158-1

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Ocular fundus images by scanning laser ophthalmoscopy in a patient with enhanced S-cone syndrome 査読

T Usui, M Ichibe, N Tanimoto, S Ueki, M Takagi, S Hasegawa, H Abe, Y Miyagawa, M Nakazawa

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 24 ( 6 ) 946 - 952 2004年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Purpose: To present ocular fundus images in a patient with enhanced S-cone syndrome by scanning laser ophthalmoscopy. A 34-year-old Japanese woman whose parents were consanguineous showed mismatched electroretinographic responses to photopically balanced single-flash stimuli, with a larger signal to blue light than to red light. The central macula lacked a foveal reflex, and the surface was dull. Yellowish flecks and retinal pigment epithelium atrophy were evident in a ring at and around the vascular arcades. Faint black pigmentation was deposited in the mid peripheral retina.
Methods: The ocular fundus of the patient was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium-neon laser (633 nm), and an infrared laser (780 nm).
Results: The argon blue laser showed numerous black spots of pigment, which were observed as faint pigmentation by conventional ophthalmoscopy. The spots were more enhanced with the argon blue laser than with the helium-neon laser. The white spots, which corresponded to the yellowish flecks in a ring at and around the vascular arcades, were more enhanced with the helium-neon laser than with the argon blue or infrared laser. Hypopigmentation of the retinal pigment epithelium was best shown with the infrared laser.
Conclusion: An abnormality of the retinal structure in enhanced S-cone syndrome may exist in the inner and outer retinal levels, in at least some patients.

DOI： 10.1097/00006982-200412000-00016

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[A case of acute angle-closure glaucoma secondary to annular ciliochoroidal detachment after unsutured cataract surgery] 査読

Ueki S, Fukuchi T, Funaki S, Wakai M, Sawada H, Suda K, Tanaka Y, Nakatsue T, Ohta A, Hara H, Shirakashi M, Abe H

Nihon Ganka Gakkai Zasshi 108 ( 4 ) 219 - 225 2004年4月

無縫合白内障手術後の輪状毛様体脈絡膜剥離による急性閉塞隅角緑内障の1例査読

植木智志, 大学院医歯学総合研究科生体機能調節医学専攻感覚統合医学講座視覚病態学分野, 福地健郎, 船木繁雄, 若井美喜子, 澤田英子, 須田生英子, 田中陽子, 中枝智子, 太田亜紀子, 原浩昭, 白柏基宏, 阿部春樹

日本眼科学会雑誌 108 ( 4 ) 219 - 225 2004年4月

ERG rod a-wave in Oguchi disease 査読

T Usui, N Tanimoto, S Ueki, M Takagi, S Hasegawa, H Abe, K Sekiya, M Nakazawa

VISION RESEARCH 44 ( 5 ) 535 - 540 2004年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

We analyzed the change in the ERG rod a-wave waveform during the course of dark adaptation in two patients with Oguchi disease. Two Japanese patients showed a homozygous arrestin 1147delA mutation. Scotopic flash ERGs were recorded after different periods of dark adaptation. ERG rod a-waves were obtained after subtraction of the cone ERG contribution. The rod a-waves were fitted with a model of the rod receptor signal. The parameters, Rm(p3) (maximum a-wave amplitude) and S (sensitivity) were calculated. Longer periods in the dark produced larger rod a-wave but only to the first flash presented. The amplitude of the response to subsequent flashes was essentially independent of the period of dark adaptation. Rm(p3) increased with advance of dark adaptation. However, S was nearly constant. Our results suggest that the cause of delayed dark adaptation is not to be sought in the activation of phototransduction process or the regeneration of rhodopsin per se but rather in the deactivation process of the phototransduction cascade. (C) 2003 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.visres.2003.06.003

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Mizuo phenomenon observed by scanning laser ophthalmoscopy in a patient with Oguchi disease 査読

T Usui, M Ichibe, S Ueki, M Takagi, S Hasegawa, H Abe, K Sekiya, M Nakazawa

AMERICAN JOURNAL OF OPHTHALMOLOGY 130 ( 3 ) 359 - 361 2000年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

PURPOSE: To elucidate the origin of the abnormal fundus reflex in Oguchi disease,
METHODS: The ocular fundus of a 63-year-old woman who showed a homozygous arrestin 1147delA mutation was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium neon laser (633 nm), and an infrared laser (780 nm).
RESULTS: Diffuse, fine, white particles, which do not exist in normal subjects, were clearly demonstrated only with the helium-neon laser. After 4-hour dark adaptation, the abnormal particles disappeared, but then they reappeared gradually during 30 minutes of light adaptation, in accordance with the golden metallic reflex.
CONCLUSION: The white particles found by helium-neon laser could be the origin of the abnormal fundus reflex in Oguchi disease. (C) 2000 by Elsevier Science Inc. All rights reserved.

DOI： 10.1016/S0002-9394(00)00532-8

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眼圧上昇を伴った甲状腺眼症査読

高木峰夫, 植木智志, 長谷川茂, 臼井知聡, 長谷部日, 三木淳司, 高田律子, 早川祐貴, 阿部春樹

神経眼科 16 ( 3 ) 331-336 - 336 1999年

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