Updated on 2025/09/09

写真a

 
SHOBUGAWA Yugo
 
Organization
Graduate School of Medical and Dental Sciences Specially Appointed Professor
Title
Specially Appointed Professor
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Degree

  • 医学博士 ( 2008.3   新潟大学 )

Research Interests

  • Social Epidemiology

  • Public Health

  • Global Health

  • Social Capital

  • Geographic Information System

Research Areas

  • Life Science / Hygiene and public health (non-laboratory)

Research History (researchmap)

  • Ministry of Health, Labor and Welfare   Coronavirus Infectious Disease Control Team   Member

    2020.2

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    Country:Japan

    Notes:厚生労働省新型コロナウィルスに関連した感染症対策に関する厚生労働省対策推進本部事務局参与

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  • Niigata University Graduate School of Medical and Dental Sciences (donated by Tokamachi city, Niigata Japan   Department of Active Aging   Specially Appointed Professor   特任教授

    2019.10

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    Country:Japan

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  • Tokyo Medical and Dental University   Graduate School of Medical and Dental Sciences

    2019.4

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    Country:Japan

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  • Tohoku University   Graduate School of Medicine

    2018.4

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    Country:Japan

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  • Niigata University Graduate School of Medical and Dental Sciences   Division of International Health   Associate Professor

    2014.2 - 2019.9

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  • Niigata University Graduate School of Medical and Dental Sciences   Division of International Health   Assistant Professor

    2011.8 - 2014.1

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Research History

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Professor

    2019.10

  • Niigata University   Faculty of Medicine School of Medicine   Associate Professor

    2014.2 - 2019.9

  • Niigata University   Graduate School of Medical and Dental Sciences Community Disease Control Infectious Disease Control and International Medicine   Associate Professor

    2014.2 - 2019.9

  • Niigata University   Faculty of Medicine School of Medicine   Assistant Professor

    2011.8 - 2014.1

  • Niigata University   Graduate School of Medical and Dental Sciences Community Disease Control Infectious Disease Control and International Medicine   Assistant Professor

    2011.8 - 2014.1

Professional Memberships

  • THE JAPANESE ASSOCIATION OF RURAL MEDICINE

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • JAPANESE SOCIETY OF PUBLIC HEALTH

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  • JAPAN ASSOCIATION FOR INTERNATIONAL HEALTH

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  • JAPAN EPIDEMIOLOGICAL ASSOCIATION

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Committee Memberships

  • Niigata Medical Coordination Headquarters   Member of the Niigata Coronavirus Infectious Disease Control Expert Meeting  

    2020.5   

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    Committee type:Municipal

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  • 新潟県庁   健診データ等を活用した健康課題の分析に関するワーキンググループ委員  

    2018.9 - 2019.3   

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    Committee type:Academic society

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  • 新潟県庁   健診データ等を活用した健康課題の分析に関する研究会委員  

    2018.9 - 2019.3   

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    Committee type:Municipal

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  • 新潟市役所   健康寿命延伸に向けたカンファレンス委員  

    2018.4 - 2019.3   

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    Committee type:Municipal

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  • 新潟県庁   新潟県環境審議会委員  

    2017.4   

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Studying abroad experiences

  • Loma Linda University   PosDoc Fellow

    2010.8 - 2011.7

 

Papers

  • Association between social capital and mortality among community-dwelling older adults in Myanmar 2018–2022: a prospective cohort study

    Yuka Ohaku, Yuki Shirakura, Yuiko Nagamine, Yuri Sasaki, Daisuke Takagi, Ikuma Nozaki, Than Win Nyunt, Reiko Saito, Yugo Shobugawa

    BMC Global and Public Health   3 ( 1 )   2025.3

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Background

    Healthy aging is crucial in Asia given its rapidly aging society. Social capital, which refers to the resources derived from social networks, norms, and trust that facilitate cooperation and collective action within a community or society, has demonstrated health benefits for older adults. However, its impact varies by country. Most research focuses on high-income countries, with little attention on low- and middle-income countries.

    Methods

    This prospective cohort study examined the effects of social capital on all-cause mortality among older adults in Myanmar from 2018 to 2022, using structured questionnaires based on the Japan Gerontological Evaluation Study. Multistage random sampling and face-to-face interviews were conducted with community-dwelling older adults aged 60 and above in Yangon and Bago in 2018. Subsequently, three waves of follow-up telephone surveys were conducted in 2020, 2021, and 2022. The questionnaires evaluated three components of social capital: civic participation, social cohesion, and social support, alongside baseline demographic information. Their impact on all-cause mortality was assessed using the Cox proportional hazards model with multiple imputations, adjusting for potential confounders including age, gender, body mass index, self-rated health, socioeconomic status, lifestyle, illness, and residential area.

    Results

    A total of 1200 individuals were followed for an average of 2.6 years (3123 person-years), with 143 all-cause deaths observed among 1031 participants. Bivariate analyses showed that participants who died were more likely to be older, underweight, have shorter daily walking times, live in Bago, and have less social support. Higher social support was significantly associated with lower mortality after adjusting for all covariates (HR = 0.80, 95% CI 0.69–0.94). Specifically, instrumental support, defined as the exchange of practical assistance, such as receiving or providing care during illness, was found to be protectively associated with mortality. When stratified by residential area, significant associations were found only in Bago, a rural area. Among older adults in Myanmar, instrumental support was a more prominent protector against all-cause mortality than emotional support, especially in rural areas.

    Conclusions

    Our findings indicate that social support networks play an important role in the survival of older adults in Myanmar, even under unstable social conditions.

    DOI: 10.1186/s44263-025-00137-x

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    Other Link: https://link.springer.com/article/10.1186/s44263-025-00137-x/fulltext.html

  • 社会的処方の実装~小規模実証から展開へ~

    菖蒲川由郷

    2024.12

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    Publishing type:Research paper (conference, symposium, etc.)  

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  • Parental vaccine hesitancy toward routine childhood immunizations and COVID-19 vaccines in Japan: A cross-sectional study. International journal

    Aya Saitoh, Yugo Shobugawa

    BMC public health   24 ( 1 )   3303 - 3303   2024.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: This study aimed to elucidate the prevalence and characteristics of parental vaccine hesitancy towards routine infant immunizations and COVID-19 vaccines in Japan. METHODS: A web-based survey was conducted among 3,227 parents of children aged 0-11 years to assess vaccine-related hesitancy for routine infant immunizations and COVID-19 vaccines for children using the Parent Attitudes about Childhood Vaccines (PACV) questionnaire. Data were collected from January 18 to 25, 2023. Covariates included demographic characteristics, economic status, COVID-19 infection status, decisional conflict scale, and the fear of COVID-19 Scale. RESULTS: Vaccine hesitancy was found to be 52.4% for routine infant immunizations and 73% for COVID-19 vaccines. Significant differences in parental attitudes were observed between general childhood vaccines and COVID-19 vaccines for 12 out of 13 PACV survey items. The COVID-19 vaccines showed higher hesitancy rates in 10 items; largest discrepancies were noticed in schedule adherence (22.5% vs 61%), overall hesitancy (40% vs 55.1%), and trust in pediatric doctors (37.2% vs 53.6%). Safety concerns were high for both vaccine types, exceeding 50%. Multivariable analysis identified decisional conflict (RR: 1.01 95% CI: 1.00-1.02) and COVID-19-related fear (RR: 1.04, 95% CI: 1.02-1.05) as hesitancy predictors for routine immunizations. CONCLUSION: Vaccine-related hesitancy for COVID-19 was significantly higher than that for routine immunizations, with decisional conflict emerging as a primary predictor for both. Fear of COVID-19 was associated with routine immunization-related hesitancy. These findings provide critical insights for future pandemic preparedness and vaccine acceptance strategies, highlighting the importance of strengthening trust between healthcare providers and parents, providing clear and reliable information, and implementing decision support tools.

    DOI: 10.1186/s12889-024-20845-7

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  • とおかまち健康の処方箋 社会的処方の地域実装に向けた糖尿病患者に対する小規模実証 Reviewed

    児玉 康子, 白倉 悠企, 川田 亮, 吉嶺 文俊, 菖蒲川 由郷

    日本公衆衛生学会総会抄録集   381 - 381   2024.10

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  • とおかまち健康の処方箋 データに基づく健康課題抽出と要因分析 Reviewed

    石坂 秀壮, 伴 秀行, 大崎 高伸, 長谷川 泰隆, 菖蒲川 由郷, 白倉 悠企, 児玉 康子

    日本公衆衛生学会総会抄録集   381 - 381   2024.10

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  • 社会経済的地位の軌跡と認知症に関連する局所脳容積との関連 NEIGE研究の結果

    森田 彩子, 藤原 武男, 村山 洋史, 町田 征己, 井上 茂, 菖蒲川 由郷

    日本公衆衛生学会総会抄録集   83回   285 - 285   2024.10

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    Language:Japanese   Publisher:日本公衆衛生学会  

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  • Impact of social isolation on change in brain volume in community-dwelling older Japanese people: The NEIGE Study. International journal

    Hiroshi Murayama, Ai Iizuka, Masaki Machida, Shiho Amagasa, Shigeru Inoue, Takeo Fujiwara, Yugo Shobugawa

    Archives of gerontology and geriatrics   129   105642 - 105642   2024.9

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    BACKGROUND: Several studies have shown that social isolation is a risk factor for cognitive decline and dementia; however, its neurological mechanisms are not fully understood. Using longitudinal data, this study examined the effects of social isolation on hippocampal and total gray matter volumes in community-dwelling older Japanese individuals. METHODS: Data were obtained from the Neuron to Environmental Impact Across Generations (NEIGE) Study conducted in Tokamachi City (Niigata Prefecture, Japan), including 279 community-dwelling persons aged 65-84 years who underwent brain magnetic resonance imaging in 2017 and 2021 (male: 47.6 %; mean age: 73.0 years). We investigated two dimensions of social isolation: poor social networks and solitary living. RESULTS: Multiple regression analysis with inverse probability weighting showed that individuals with a social contact frequency of <1 time/week had a greater decrease in hippocampal volume than those with a contact frequency of more than or equal to 4 times/week, whereas those who lived alone tended to have a smaller decrease in hippocampal volume than those who lived with others. We found no association between the frequency of social contact, living alone, and total gray matter volume. Furthermore, there was no interaction between sex and age for any of the outcomes. CONCLUSION: Our longitudinal analysis suggested that the relationship between social isolation and dementia onset may be mediated by hippocampal atrophy; however, the direction of the influence depends on the isolation type. These findings are expected to contribute to the elucidation of the social mechanisms underlying dementia onset.

    DOI: 10.1016/j.archger.2024.105642

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  • Childhood Book Availability Helps to Preserve Cognitive Function in Older Adults With Low Education: Results From the NEIGE Study. International journal

    Yukako Tani, Tomoki Kawahara, Genichi Sugihara, Masaki Machida, Shiho Amagasa, Hiroshi Murayama, Shigeru Inoue, Takeo Fujiwara, Yugo Shobugawa

    The journals of gerontology. Series B, Psychological sciences and social sciences   79 ( 6 )   2024.6

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    OBJECTIVES: It is well known that low educational attainment is associated with cognitive function decline in older age. Childhood book availability may help to preserve cognitive function in older adults with low education. The study objective was to examine the association between childhood book availability and cognitive function among older adults with low educational attainment, and to investigate the mediating effect of the volume of reading-related brain regions (e.g., superior temporal cortex). METHODS: A cross-sectional study of community-dwelling older Japanese adults aged 65-84 years was conducted (n = 474). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Childhood book availability was assessed using a retrospective questionnaire. Brain region volume was measured using magnetic resonance imaging. Multivariate regression modeling and structural equation modeling were used for analysis. RESULTS: Both high educational attainment and childhood book availability were independently associated with high MMSE score. Stratification of educational level showed that childhood book availability was positively associated with MMSE score among participants with low educational attainment (coefficient = 1.48, 95% confidence interval [CI]: 0.31 to 2.66), but not among those with moderate or high educational attainment (coefficient = -0.01, 95% CI: -1.44 to 1.42 and -1.21, 95% CI: -3.85 to 1.42, respectively). Among participants with low educational attainment, left superior temporal cortex volume mediated the association between childhood book availability and MMSE score. DISCUSSION: The availability of books in childhood helps to preserve cognitive function in older adults with low education via left superior temporal cortex volume. Further research is needed to replicate these findings.

    DOI: 10.1093/geronb/gbae052

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  • Association Between Trajectory of Socioeconomic Position and Regional Brain Volumes Related to Dementia: Results From the NEIGE Study. International journal

    Ayako Morita, Takeo Fujiwara, Hiroshi Murayama, Masaki Machida, Shigeru Inoue, Yugo Shobugawa

    The journals of gerontology. Series A, Biological sciences and medical sciences   79 ( 5 )   2024.5

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    BACKGROUND: Low socioeconomic position (SEP) has been linked to an increased risk of dementia. However, little is known about the association between SEP trajectory and regional brain volumes related to dementia. METHODS: A random sample of community-dwelling older adults (n = 428, age = 73.1 ± 5.5) living in Tokamachi City (Niigata Prefecture, Japan) without medical histories of dementia, Parkinson's disease, and depression who underwent automated assessment of brain volumes on magnetic resonance imaging and responded to a self-administered questionnaire survey in 2017. We measured SEP in childhood (household SEP at age 15), young adulthood (education), mid-adulthood (the longest occupation), and late adulthood (current wealth), and further performed group-based trajectory analysis to identify lifetime trajectory patterns on SEP. Multivariate regression models were employed to investigate the association between SEP trajectories and 4 regional brain volumes related to the development of Alzheimer's disease (ie, entorhinal cortex, hippocampus, amygdala, and the parahippocampus), the most common type of dementia. RESULTS: We found 3 distinct SEP trajectories (stable middle class [68%], downward [23%], and upward [9%]). Compared to those who experienced stable middle class, older adults who experienced the upward SEP mobility had significantly larger hippocampus (β: 213.2, 95% confidence interval: 14.7, 411.8). On the other hand, older adults who experienced downward SEP mobility showed no significant differences in any of the 4 brain structural volumes. CONCLUSIONS: Our findings indicate that upward life-course SEP mobility is associated with larger volumes of hippocampus in old age. SEP trajectory may offer us a useful lens to enhance our understanding of the etiology of dementia.

    DOI: 10.1093/gerona/glad269

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  • Association between Internet use and depressive symptoms among older adults in two regions of Myanmar: a cross-sectional study

    Yuri Sasaki, Yugo Shobugawa, Ikuma Nozaki, Daisuke Takagi, Yuiko Nagamine, Yuki Shirakura, Kay Thi Lwin, Poe Ei Zin, Thae Zarchi Bo, Tomofumi Sone, Hla Hla Win

    BMC Geriatrics   24 ( 1 )   2024.2

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    Abstract

    Background

    Internet use has both positive and negative effects on mental health. However, few studies have examined the association between internet use and mental health among older adults in developing countries. This study aimed to investigate the association between Internet use and depressive symptoms among older adults in two regions of Myanmar.

    Methods

    Data based on a visit to 1,200 older adults in urban and rural Myanmar were obtained through stratified random sampling using the cross-sectional baseline survey of the longitudinal study titled “Healthy and Active Aging in Myanmar.”

    Our analysis included 1,186 participants. The dependent variable was depressive symptoms, and the 15-item version of the Geriatric Depression Scale (GDS) was used as a continuous variable; the higher the score, the more likely a person was to be depressed. Internet use (one of the questions about household property ownership) was used as an independent variable. After confirming the absence of multicollinearity, we adjusted for age, gender, educational background, activities of daily living, residential area, and frequency of meeting friends, and stratified by subjective economic status (above or below average). We also examined the interaction between internet use and subjective economic status. A linear regression analysis was performed.

    Results

    Among the 1,186 participants included in the analysis (women: 59.5%; median age: 68 years old), 202 (17.0%) were Internet users (95% Confidential Interval [CI]: 0.15, 0.19), and they had significantly lower GDS scores than the participants who did not use the Internet (B: -1.59, 95% CI: -2.04, -1.13).GDS showed a negative association with Internet use even in the multivariate analysis (B: -0.95, 95% CI: -1.41, -0.50). However, the interaction term for GDS between Internet use and subjective economic status was not significantly associated (B: 0.43, 95% CI: -1.11, 1.98).

    Conclusions

    Internet use and depressive symptoms were associated especially among the older adults. However, there were no significant interaction between Internet use and subjective economic status for GDS.

    DOI: 10.1186/s12877-024-04729-4

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    Other Link: https://link.springer.com/article/10.1186/s12877-024-04729-4/fulltext.html

  • Detection of enterovirus D68 among children with severe acute respiratory infection in Myanmar Reviewed

    Tatsuki Ikuse, Yuta Aizawa, Ryotaro Kachikawa, Kazuhiro Kamata, Hidekazu Osada, Su Mon Kyaw Win, Lasham Di Ja, Nay Chi Win, Khin Nyo Thein, Aye Thida, Aye Tun, Ai Ito, Yadanar Kyaw, Htay Htay Tin, Yugo Shobugawa, Hisami Watanabe, Reiko Saito, Akihiko Saitoh

    Journal of Microbiology, Immunology and Infection   2024.1

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    DOI: 10.1016/j.jmii.2024.01.001

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  • 近隣環境の美しさは高齢者のどの脳領域と関連するか?

    谷 友香子, 藤原 武男, 杉原 玄一, 花里 真道, 鈴木 規道, 町田 征己, 天笠 志保, 村山 洋史, 井上 茂, 菖蒲川 由郷

    Journal of Epidemiology   34 ( Suppl. )   107 - 107   2024.1

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    Language:Japanese   Publisher:(一社)日本疫学会  

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  • 高齢者の食の多様性と脳容積の変化 NEIGE study

    尾白 有加, 白倉 悠企, 村山 洋史, 町田 征己, 井上 茂, 藤原 武男, 菖蒲川 由郷

    Journal of Epidemiology   34 ( Suppl. )   111 - 111   2024.1

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  • 近隣環境の美しさは高齢者のどの脳領域と関連するか?

    谷 友香子, 藤原 武男, 杉原 玄一, 花里 真道, 鈴木 規道, 町田 征己, 天笠 志保, 村山 洋史, 井上 茂, 菖蒲川 由郷

    Journal of Epidemiology   34 ( Suppl. )   107 - 107   2024.1

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    Language:Japanese   Publisher:(一社)日本疫学会  

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  • 高齢者の食の多様性と脳容積の変化 NEIGE study

    尾白 有加, 白倉 悠企, 村山 洋史, 町田 征己, 井上 茂, 藤原 武男, 菖蒲川 由郷

    Journal of Epidemiology   34 ( Suppl. )   111 - 111   2024.1

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  • ミャンマーの高齢者の野菜・果物摂取頻度とうつ傾向の関連

    佐々木 由理, 菖蒲川 由郷, 野崎 威功真, 高木 大資, 長嶺 由衣子, 山本 貴文, 谷 友香子

    日本公衆衛生学会総会抄録集   82回   548 - 548   2023.10

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  • 高齢者のソーシャルサポートと脳容積の変化 NEIGE studyより

    菖蒲川 由郷, 白倉 悠企, 尾白 有加, 町田 征己, 村山 洋史, 藤原 武男, 井上 茂

    日本公衆衛生学会総会抄録集   82回   446 - 446   2023.10

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  • Detection of parechovirus-A in hospitalized children with acute lower respiratory infection in Myanmar, 2017-2018. International journal

    Jun Tachikawa, Yuta Aizawa, Tetsuya Kobayashi, Tatsuki Ikuse, Kazuhiro Kamata, Su Mon Kyaw Win, Lasham Di Ja, Khin Nyo Thein, Nay Chi Win, Aye Thida, Aye Tun, Yuko Suzuki, Ai Ito, Hidekazu Osada, Irina Chon, Wint Wint Phyu, Tomomi Ota, Yadanar Kyaw, Htay Htay Tin, Kanako Watanabe, Yugo Shobugawa, Hisami Watanabe, Reiko Saito, Akihiko Saitoh

    Journal of medical virology   95 ( 7 )   e28964   2023.7

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    Parechovirus-A (PeV-A) causes emerging infection in children, and clinical presentation depends on genotype. The virus has been investigated mainly in developed countries; however, data from developing countries, especially in Asia, are sparse. This study investigated whether PeV-A circulated in children in Myanmar. This retrospective study evaluated PeV-A in nasopharyngeal samples from children aged 1 month to 12 years who were hospitalized with acute lower respiratory infection at Yankin Children Hospital, Yangon, Myanmar, during the period from May 2017 to April 2019. Real-time polymerase chain reaction (PCR) was used to detect PeV-A, and PCR-positive samples were used for genotyping and phylogenetic analysis. In total, 11/570 (1.9%) of samples were positive for PeV-A; 7 were successfully genotyped by sequencing the VP3/VP1 region, as follows: PeV-A1 (n = 4), PeV-A5 (n = 1), PeV-A6 (n = 1), and PeV-A14 (n = 1). Median age was 10.0 months (interquartile range 4.0-12.0 months), and other respiratory viruses were detected in all cases. Phylogenetic analysis showed that all detected PeV-A1 strains were in clade 1 A, which was a minor clade worldwide. Four PeV-A genotypes were detected in Myanmar. The clinical impact of PeV-A in children should be evaluated in future studies.

    DOI: 10.1002/jmv.28964

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  • 新潟県における大腿骨近位部骨折発生状況の推移 2020年新潟県高齢者骨折調査より

    野崎 あさみ, 今井 教雄, 菖蒲川 由郷, 堀米 洋二, 鈴木 勇人, 遠藤 直人, 川島 寛之

    日本骨粗鬆症学会雑誌   9 ( 2 )   241 - 245   2023.5

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  • The association of subjective vision with objectively measured intensity-specific physical activity and bout-specific sedentary behavior among community-dwelling older adults in Japan.

    Kazuho Isamu, Tomoko Takamiya, Shiho Amagasa, Masaki Machida, Hiroyuki Kikuchi, Noritoshi Fukushima, Shigeru Inoue, Hiroshi Murayama, Takeo Fujiwara, Yugo Shobugawa

    Japanese journal of ophthalmology   67 ( 2 )   164 - 174   2023.1

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    PURPOSE: Visual impairment is a possible cause of physical frailty. Reduced physical activity (PA) may be involved in the pathway from visual impairment to physical frailty, although the association between vision and objectively measured PA among older adults remains unclear. This study examined the sex-specific association of subjective vision with intensity-specific PA and bout-specific sedentary behavior (SB) among community-dwelling, older Japanese adults. STUDY DESIGN: Cross-sectional study METHODS: This study used data from the Neuron to Environmental Impact across Generations study analyzing older adults (527 participants, aged 65-84 years) living in rural areas of Niigata Prefecture, Japan. Subjective vision was assessed by use of a questionnaire. Intensity-specific PA (light-intensity PA and moderate-to-vigorous PA [MVPA]), bout-specific SB, and daily step count were objectively evaluated by use of an accelerometer. The association of subjective vison with PA and SB, stratified by sex, was analyzed by means of general regression analyses, with adjustment for covariates. RESULTS: The data of 512 participants (men: 46.9%; with poor subjective vision: 22.9%) were analyzed. Poor subjective vision was significantly associated with log MVPA (partial regression coefficient = -0.261, P = .013) and log steps (partial regression coefficient = -0.164; P = .021) among women, whereas a tendency of an association was observed with prolonged SB time among men (partial regression coefficient: 39.1; P = .073). CONCLUSION: Older Japanese women with poor subjective vision performed less MVPA and had fewer step counts than those of participants with good subjective vision, and men with poor subjective vision had longer prolonged SB, which may all accelerate the process to physical frailty.

    DOI: 10.1007/s10384-023-00977-w

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  • Associations between socioeconomic status and adherence to hypertension treatment among older adults in urban and rural areas in Myanmar: a cross-sectional study using baseline data from the JAGES in Myanmar prospective cohort study

    Yuiko Nagamine, Yugo Shobugawa, Yuri Sasaki, Daisuke Takagi, Takeo Fujiwara, Yu Par Khin, Ikuma Nozaki, Yuki Shirakura, Lwin Kay Thi, Zin Poe Ei, Zarchibo Thae, Hla Hla Win

    BMJ Open   13 ( 1 )   e065370 - e065370   2023.1

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    Objectives

    This study aims to investigate whether there is a differential association between socioeconomic status (SES) and adherence to hypertension medication among older adults in rural and urban areas in Myanmar and assess what type of SES is associated with a difference.

    Design

    Cross-sectional study using baseline data from the Japan Gerontological Evaluation Study in Myanmar prospective cohort study. A multistage random sampling method was applied in each region.

    Setting

    An urban and a rural area in Myanmar.

    Participants

    A total of 1200 older adults over 60 years old in Myanmar were randomly selected in 2018 (600 each from rural and urban areas). Of them, 573 had hypertension and were eligible for the analysis (urban: 317, rural: 256).

    Outcome

    Adherence to hypertension medication (yes/no) is the outcome of interest. Three types of SES (wealth, education and current employment status) were the independent variables.

    Results

    We found that 21.5% of urban residents and 48.4% of rural residents were non-adherent in the study population. Poisson regression modelling stratified by area was performed to estimate the prevalence ratios (PRs) of not following treatment instructions. Demographic information and complications of hypertension were adjusted for in all models as possible confounders. In terms of SES, middle level of wealth compared with low level was significantly associated with poor adherence (PR 2.68, 95% CI 1.28 to 5.59) in the urban area, but education and employment status did not show similar associations. Lower education compared with middle/high school or higher was significantly associated with poor adherence in the rural area (no school: PR 3.22, 1.37–7.58; monastic: 3.42, 1.16–5.07; primary school: 2.41, 1.18–4.95), but wealth and income did not show similar associations.

    Conclusions

    SES and adherence to hypertension medication were differently associated among older adults in rural and urban areas in Myanmar. To ensure healthcare access to hypertension treatment for every citizen, the differential association between SES and adherence in urban/rural areas needs to be recognised.

    DOI: 10.1136/bmjopen-2022-065370

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  • Neighborhood Beauty and the Brain in Older Japanese Adults Reviewed International journal

    Yukako Tani, Takeo Fujiwara, Genichi Sugihara, Masamichi Hanazato, Norimichi Suzuki, Masaki Machida, Shiho Amagasa, Hiroshi Murayama, Shigeru Inoue, Yugo Shobugawa

    International Journal of Environmental Research and Public Health   20 ( 1 )   2022.12

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    People have a preference for, and feel better in, beautiful natural environments. However, there are no epidemiological studies on the association between neighborhood beauty and neuroimaging measures. We aimed to determine association between neighborhood beauty and regional brain volume. Participants were 476 community-dwelling older adults from the Neuron to Environmental Impact across Generations (NEIGE) study. Subjective neighborhood beauty was assessed through participants' perception of beautiful scenery within 1 km of their home. Objective measures of neighborhood indicators (green spaces, blue spaces, and plant diversity) within 1 km of participants' homes were obtained using a geographic information system. Volumes of brain regions associated with experience of beauty were measured using magnetic resonance imaging. We estimated associations between neighborhood beauty and regional brain volume using linear regression. Of the participants, 42% rated their neighborhoods as very beautiful, and 17% rated them as not at all beautiful. Higher subjective neighborhood beauty was associated with larger bilateral medial orbitofrontal cortex and insula volumes (all p for trend &lt; 0.01). Brain volume was not associated with objective neighborhood measures. Subjective neighborhood beauty was associated with brain regions related to rewards and decision making, suggesting that these brain regions underpin the perception of neighborhood beauty.

    DOI: 10.3390/ijerph20010679

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  • Pneumonia and subsequent risk of dementia: Evidence from the Japan Gerontological evaluation study. International journal

    Paramita Khairan, Kokoro Shirai, Yugo Shobugawa, Dorina Cadar, Tami Saito, Katsunori Kondo, Tomotaka Sobue, Hiroyasu Iso

    International journal of geriatric psychiatry   37 ( 11 )   2022.11

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    BACKGROUND: Recently, several studies reported that pneumonia might increase the risk of cognitive decline and dementia due to increased frailty. OBJECTIVES: This study aims to examine the association between a history of pneumonia and subsequent dementia risk. METHODS: Participants were 9952 aged 65 years or older Japanese men and women from the Japan Gerontological Evaluation Study prospective cohort study, followed up from 2013 to 2019. Dementia was identified by public long-term care insurance registration. A history of pneumonia contracted 1 year before the baseline questionnaire in 2013. A cox regression model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia risk, adjusted for potential confounding variables. We conducted competing risk analyses using a cause-specific hazard model. RESULTS: During the follow-up period of 6 years, 939 persons developed dementia. There was no association between having a prior history of pneumonia with dementia risk (HR 1.20, 95% CI:0.81-1.78). However, we observed an increased risk of dementia in persons with pre-frailty and frailty; the multivariable HR (95% CI) was 1.75 (1.48-2.07) and 2.42 (2.00-2.93) for pre-frailty and frailty, respectively. When pneumonia and frailty were combined, the risk of dementia was the highest for the persons with a history of pneumonia and frailty; the multivariable HR (95% CI) was 2.30 (1.47-3.62). The multivariable HR (95% CI) for those without pneumonia with frailty was 1.95 (1.66-2.28). Meanwhile, the multivariable HR (95% CI) for those with pneumonia without frailty was 1.64 (0.68-3.99). CONCLUSION: Our findings imply that a prior history of pre-frailty and frailty with or without pneumonia, but not a history of pneumonia per se, was associated with an increased risk of dementia among population-based-cohort of older Japanese people.

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  • 新潟県における大腿骨近位部骨折発生状況の推移 2020年新潟県高齢者骨折調査より

    野崎 あさみ, 今井 教雄, 菖蒲川 由郷, 鈴木 勇人, 堀米 洋二, 遠藤 直人, 川島 寛之

    日本骨粗鬆症学会雑誌   8 ( Suppl.1 )   88 - 88   2022.8

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  • Pilot Study of Evaluating Attitudes toward Childhood Immunization among Healthcare Workers in Japan. International journal

    Aya Saitoh, Yugo Shobugawa, Isamu Sato, Yuki Yonekura, Ai Kawabata, Akihiko Saitoh, Reiko Saito

    Vaccines   10 ( 7 )   2022.6

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    Providing appropriate immunization information during the perinatal period is important for improving immunization rates among infants and children; however, the distribution of immunization information by healthcare workers (HCWs) is not standardized in Japan. We investigated HCWs' attitudes toward childhood immunization and factors related to vaccine hesitancy. We conducted a cross-sectional descriptive survey of HCWs involved in childhood immunization in Niigata City, Japan, from November 2017 to January 2018. We assessed contextual, individual and group, and vaccine/vaccination-specific influences. Of 290 HCWs, 139 (47.9%) returned completed questionnaires. Most HCWs (87/139, 64.9%) reported providing immunization information verbally to parents; 51/87 (58.6%) spent fewer than five minutes doing so. Pediatricians provided vaccines based on the parents' best interest, whereas public health nurses and midwives emphasized government policy. Nurses had greater hesitancy related to personal perceptions and social/peer factors than pediatricians (p &lt; 0.001). Nurses were significantly more likely than pediatricians to suggest that children receive more shots than necessary (p &lt; 0.01). Nurses tended to have more negative attitudes toward vaccination and little awareness of immunization promotion compared to pediatricians. Thus, all HCWs involved in childhood immunization should receive sufficient information to provide timely and appropriate immunization to infants and children.

    DOI: 10.3390/vaccines10071055

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  • Differences in Brain Volume by Tooth Loss and Cognitive Function in Older Japanese Adults. International journal

    Yusuke Matsuyama, Takeo Fujiwara, Hiroshi Murayama, Masaki Machida, Shigeru Inoue, Yugo Shobugawa

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry   30 ( 12 )   1271 - 1279   2022.6

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    BACKGROUND: We investigated the association between tooth loss and structural brain volume and its mediating effect on the association between tooth loss and cognitive function in older Japanese. METHODS: A cross-sectional study was conducted by using the data of 494 randomly sampled community-dwelling individuals aged 65-84 years living in Tokamachi City, Japan. Total brain volume (TBV), gray matter volume (GMV), white matter volume (WMV), and hippocampal volume (HV) were measured with magnetic resonance imaging. The association of self-reported number of teeth (≥20, 1-19, and 0) with cognitive function assessed with the Japanese version of the Quick Mild Cognitive Impairment screen and structural brain volume was examined. Causal mediation analysis was performed to evaluate the mediating effect of structural brain volume. Age, sex, socioeconomic status, health behavior, comorbid conditions, and total intracranial volume were adjusted. RESULTS: Respondents with no teeth showed lower cognitive function (coefficient = -4.01; 95% confidence interval [CI]: -7.19, -0.82), lower TBV (coefficient = -10.34; 95% CI: -22.84, 2.17), and lower GMV (coefficient = -6.92; 95% CI: -14.84, 0.99) than those with ≥20 teeth (P for trends were 0.003, 0.035, and 0.047, respectively). The number of teeth was not significantly associated with WMV or HV. GMV showed a significant mediating effect on the association between the number of teeth and cognitive function (coefficient = -0.38; 95% CI: -1.14, -0.002, corresponding to 9.0% of the total effect), whereas TBV did not. CONCLUSIONS: GMV was suggested to mediate the relationship between tooth loss and lower cognitive function.

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  • Do Community Social Capital and Built Environment Associate With Homebound in Older Adults? The JAGES Niigata Study.

    Tomoko Tsubokawa, Yugo Shobugawa, Seitaro Iguchi, Tsubasa Suzuki, Michiko Watanabe, Reiko Saito, Katsunori Kondo

    Journal of epidemiology   32 ( 6 )   254 - 269   2022.6

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    BACKGROUND: Homebound status is one of the most important risk factors associated with functional decline and long-term care in older adults. Studies show that neighborhood built environment and community social capital may be related to homebound status. This study aimed to clarify the association between homebound status for community-dwelling older adults and community environment-including social capital and neighborhood built environment-in rural and urban areas. METHODS: We surveyed people aged 65 years and older residing in three municipalities of Niigata Prefecture, Japan, who were not certified as requiring long-term care. The dependent variable was homebound status; explanatory variables were community-level social capital and neighborhood built environment. Covariates were age, sex, household, marital status, socioeconomic status, instrumental activities of daily living, the Geriatric Depression Scale-15, self-rated health, number of diseases under care, and individual social capital. The association between community social capital or neighborhood built environment and homebound status, stratified by rural/urban areas, was investigated using multilevel logistic regression analysis. RESULTS: Among older adults (n = 18,099), the homebound status prevalence rate was 6.9% in rural areas and 4.2% in urban areas. The multilevel analysis showed that, in rural areas, fewer older adults were homebound in communities with higher civic participation and with suitable parks or pavements for walking and exercising. However, no significant association was found between community social capital or neighborhood built environment and homebound status for urban older adults. CONCLUSION: Community social capital and neighborhood built environment were significantly associated with homebound status in older adults in rural areas.

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  • Association between Happiness and Economic Status among Older Adults in Two Myanmar Regions

    Yuri Sasaki, Yugo Shobugawa, Ikuma Nozaki, Daisuke Takagi, Yuiko Nagamine, Masafumi Funato, Yuki Chihara, Yuki Shirakura, Kay Thi Lwin, Poe Ei Zin, Thae Zarchi Bo, Tomofumi Sone, Hla Hla Win

    International Journal of Environmental Research and Public Health   19 ( 6 )   3216 - 3216   2022.3

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    Few studies have examined whether objective or subjective economic status (ES) has a greater association with the happiness of older adults, despite concerns regarding the growing economic cost of morbidity and their functional dependence in developing countries with aging populations. Thus, this study examined whether objective/subjective ES was associated with happiness in older adults in two Myanmar regions. A multistage random sampling procedure and face-to-face interviews were conducted in the urban and rural areas of Myanmar. The happiness of 1200 participants aged &gt;60 years was evaluated using a single happiness score ranging from 0 (very unhappy) to 10 (very happy). The wealth index, used as an objective ES, was calculated from 17 household asset items, such as radio, washing machines, and television. Subjective ES was assessed by asking “Which of the following best describes your current financial situation in light of general economic conditions?” Responses ranged from “very difficult” to “very comfortable”. Both low objective and subjective ES were negatively associated with happiness, after adjusting for confounding variables and stratification by region (urban and rural areas). Although objective and subjective ES had similar associations with happiness in urban areas, subjective ES had a stronger association in rural areas.

    DOI: 10.3390/ijerph19063216

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  • 地域在住高齢者における"見えづらさ"と強度別身体活動の関連について

    薫 一帆, 高宮 朋子, 天笠 志保, 町田 征己, 菊池 宏幸, 福島 教照, 小田切 優子, 井上 茂, 村上 洋史, 藤原 武男, 菖蒲川 由郷

    日本眼科学会雑誌   126 ( 臨増 )   309 - 309   2022.3

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  • 地域在住高齢者における"見えづらさ"と強度別身体活動の関連について

    薫 一帆, 高宮 朋子, 天笠 志保, 町田 征己, 菊池 宏幸, 福島 教照, 小田切 優子, 井上 茂, 村上 洋史, 藤原 武男, 菖蒲川 由郷

    日本眼科学会雑誌   126 ( 臨増 )   309 - 309   2022.3

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  • Incidence and length of outbreak period of COVID-19 and population density in comparison with seasonal influenza in Japan. International journal

    Hiroki Akaba, Kazuaki Jindai, Yugo Shobugawa, Hitoshi Oshitani

    IJID regions   2   154 - 157   2022.3

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    OBJECTIVES: There is no consensus regarding the impact of population density on the transmission of respiratory viral infections such as COVID-19 and seasonal influenza. Our study aimed to determine the correlation between population density and the incidence and duration of COVID-19 transmission. METHODS: Publicly available data for confirmed COVID-19 cases in Japan, from January 2020 through November 2021, were retrospectively collected. The average numbers of seasonal influenza cases reported in the national database from 2013-2014 through 2019-2020 were identified. Using data for COVID-19 and seasonal influenza population density and incidence rates (age-adjusted), the Pearson's correlation coefficient was determined. RESULTS: A significant positive correlation between log population density and length of outbreak period was observed for COVID-19 (r = 0.734; p < 0.001) but not for seasonal influenza. Additionally, a significant linear correlation was observed between population density and age-adjusted incidence rate for COVID-19 (r = 0.692; p < 0.001) but not for seasonal influenza. CONCLUSIONS: In Japan, areas with high population density experienced a prolonged and more intense COVID-19 outbreak compared with areas with low population density. This was not observed with seasonal influenza, suggesting that public health measures against COVID-19 should be tailored according to population density.

    DOI: 10.1016/j.ijregi.2022.01.003

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  • Association between adverse childhood experiences and brain volumes among Japanese community-dwelling older people: Findings from the NEIGE study. International journal

    Yuna Koyama, Takeo Fujiwara, Hiroshi Murayama, Masaki Machida, Shigeru Inoue, Yugo Shobugawa

    Child abuse & neglect   124   105456 - 105456   2022.2

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    BACKGROUND: Adverse childhood experiences (ACEs) can affect later-life health outcomes via brain structural differences. However, there is no sufficient empirical evidence about whether brain morphological differences remain until old ages. OBJECTIVE: We examined the association between ACEs and brain volumes among older individuals. PARTICIPANTS AND SETTING: Residents aged 65-84 years in Tokamachi City, Japan, were randomly recruited, and 491 participants were included in the analysis. METHODS: ACEs were assessed with a self-reported questionnaire. The volumes of seven brain regions of interests were evaluated via structural magnetic resonance imaging. RESULTS: In total, 143 (27.1%) participants experienced one ACE and 33 (6.7%) two or more ACEs. Participants with two or more ACEs had a larger anterior cingulate cortex volume (B = 0.346, 95% confidence interval [CI] = 0.04 to 0.66) and smaller hippocampal (B = -0.287, 95% CI = -0.58 to 0.001) and amygdala (B = -0.313, 95% CI = -0.59 to -0.03) volumes. Interestingly, we observed a distinct association between deprivation and threat. That is, deprivation was associated with a smaller amygdala volume (B = -0.164, 95% CI = -0.32 to -0.01) and threat with a larger anterior cingulate cortex volume (B = 0.401, 95% CI = 0.11 to 0.70). CONCLUSIONS: ACEs were associated with the volumes of brain regions such as anterior cingulate cortex, hippocampus, and amygdala, which are responsible for emotion and self-regulation in older population. The effect of ACEs on the amygdala was commonly driven by deprivation experiences and that on the anterior cingulate cortex by threat.

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  • Association between gratitude, the brain and cognitive function in older adults: Results from the NEIGE study. International journal

    Yukako Tani, Yuna Koyama, Satomi Doi, Genichi Sugihara, Masaki Machida, Shiho Amagasa, Hiroshi Murayama, Shigeru Inoue, Takeo Fujiwara, Yugo Shobugawa

    Archives of gerontology and geriatrics   100   104645 - 104645   2022.1

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    OBJECTIVES: Having gratitude is associated with reduced social isolation and depression, which are risk factors for dementia. However, it is unknown whether gratitude is directly associated with cognitive function. This study aimed to determine associations between gratitude and cognitive function and to elucidate the underlying biological mechanism by testing the mediating role of brain regions among healthy older people. METHODS: We used cross-sectional data from the 2017 Neuron to Environmental Impact across Generations (NEIGE) study of community-dwelling older adults aged ≥ 65 years (n = 478). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Levels of gratitude were assessed using the two-items of Gratitude Questionnaire. Volumes of brain regions associated with emotional processing and social interaction were measured by magnetic resonance imaging. Linear regression models and structural equation models were used to examine associations between level of gratitude, brain volume, and cognitive function. RESULTS: The mean gratitude score was 6.3 (SD=0.9) and the mean MMSE score was 27.1 (SD=2.5). Regression analysis showed that higher levels of gratitude were associated with better cognitive function (coefficient=0.25, 95% CI: 0.01, 0.49), adjusting for age, sex, education, marital status, and depressive symptoms. Higher levels of gratitude were associated with larger volumes of right amygdala and left fusiform gyrus. Structural equation model analysis showed that amygdala volumes mediated the association between gratitude and cognitive function. CONCLUSION: Higher levels of gratitude were positively associated with cognitive function, partially mediated through the amygdala, which is involved in processing emotion and memory.

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  • Do Social Ties Moderate the Association between Childhood Maltreatment and Gratitude in Older Adults? Results from the NEIGE Study. International journal

    Satomi Doi, Yuna Koyama, Yukako Tani, Hiroshi Murayama, Shigeru Inoue, Takeo Fujiwara, Yugo Shobugawa

    International journal of environmental research and public health   18 ( 21 )   2021.10

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    BACKGROUND: Childhood maltreatment can impede gratitude, yet little is known about the older population and its moderators. The aim of this study is to clarify the association between childhood maltreatment and levels of gratitude of the older population, and the moderating effect of social ties on the association. METHODS: We analyzed the data of 524 community-dwelling older adults aged 65-84 years without functional disabilities in Tokamachi City, Niigata, Japan, collected for the Neuron to Environmental Impact across Generations (NEIGE) study in 2017. Using a questionnaire, the participants rated three types of childhood maltreatment before the age of 18 (physical abuse, emotional neglect, and psychological abuse), level of gratitude, and social ties. RESULTS: We found an inverse association between emotional neglect and gratitude. Furthermore, emotional neglect was inversely associated with gratitude only for those with lower levels of social ties. CONCLUSIONS: Promoting social ties may mitigate the adverse impact of emotional neglect on the level of gratitude.

    DOI: 10.3390/ijerph182111082

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  • 加速度計で調査した農村部在住高齢者の身体活動 NEIGE study

    天笠 志保, 井上 茂, 村山 洋史, 藤原 武男, 菊池 宏幸, 福島 教照, 町田 征己, 菖蒲川 由郷

    運動疫学研究: Research in Exercise Epidemiology   23 ( 2 )   200 - 201   2021.9

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  • 加速度計で調査した農村部在住高齢者の身体活動 NEIGE study

    天笠 志保, 井上 茂, 村山 洋史, 藤原 武男, 菊池 宏幸, 福島 教照, 町田 征己, 菖蒲川 由郷

    運動疫学研究: Research in Exercise Epidemiology   23 ( 2 )   200 - 201   2021.9

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  • Decreased human respiratory syncytial virus activity during the COVID-19 pandemic in Japan: an ecological time-series analysis. International journal

    Keita Wagatsuma, Iain S Koolhof, Yugo Shobugawa, Reiko Saito

    BMC infectious diseases   21 ( 1 )   734 - 734   2021.8

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    BACKGROUND: Non-pharmaceutical interventions (NPIs), such as sanitary measures and travel restrictions, aimed at controlling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may affect the transmission dynamics of human respiratory syncytial virus (HRSV). We aimed to quantify the contribution of the sales of hand hygiene products and the number of international and domestic airline passenger arrivals on HRSV epidemic in Japan. METHODS: The monthly number of HRSV cases per sentinel site (HRSV activity) in 2020 was compared with the average of the corresponding period in the previous 6 years (from January 2014 to December 2020) using a monthly paired t-test. A generalized linear gamma regression model was used to regress the time-series of the monthly HRSV activity against NPI indicators, including sale of hand hygiene products and the number of domestic and international airline passengers, while controlling for meteorological conditions (monthly average temperature and relative humidity) and seasonal variations between years (2014-2020). RESULTS: The average number of monthly HRSV case notifications in 2020 decreased by approximately 85% (p < 0.001) compared to those in the preceding 6 years (2014-2019). For every average \1 billion (approximately £680,000/$9,000,000) spent on hand hygiene products during the current month and 1 month before there was a 0.29% (p = 0.003) decrease in HRSV infections. An increase of average 1000 domestic and international airline passenger arrivals during the previous 1-2 months was associated with a 3.8 × 10- 4% (p < 0.001) and 1.2 × 10- 3% (p < 0.001) increase in the monthly number of HRSV infections, respectively. CONCLUSIONS: This study suggests that there is an association between the decrease in the monthly number of HRSV cases and improved hygiene and sanitary measures and travel restrictions for COVID-19 in Japan, indicating that these public health interventions can contribute to the suppression of HRSV activity. These findings may help in public health policy and decision making.

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  • COVID-19 case-clusters and transmission chains in the communities in Japan

    Yiiki Furuse, Naho Tsnchiya, Reiko Miyahara, Dckoh Yasuda, Eiichiro Sando, Yura K Ko, Takeaki Imainura, Konosiike Morimoto, Tadatsugu Iinamura, Yugo Shobugawa, Shohei Nagata, Atsuna Tokiimoto, Kazuaki Jiiidai, Motoi Suzuki, Hitoshi Oshitani

    Journal of Infection   2021.8

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  • Social capital and pneumococcal vaccination (PPSV23) in community-dwelling older Japanese: a JAGES multilevel cross-sectional study. International journal

    Kousuke Iwai-Saito, Yugo Shobugawa, Katsunori Kondo

    BMJ open   11 ( 6 )   e043723   2021.6

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    OBJECTIVE: Inequalities exist between the 23-valent pneumococcal polysaccharide vaccination (PPSV23) rate in each municipality among Japanese older adults. Exploring individual-level and community-level intervenable factors is necessary to improve the vaccination rates. We examined the associations between community-level and individual-level social capital and the PPSV23 vaccination among older Japanese adults using multilevel Poisson regression analyses. DESIGN: Cross-sectional study. SETTING: We used data from the Japan Gerontological Evaluation Study, conducted between 3 October 2016 and 10 January 2017 in 631 districts, 39 municipalities and 18 prefectures. PARTICIPANTS: The target population comprised persons aged 65 years or older who are physically and cognitively independent (that is, not certified as needing long-term care). Further, 180 021 older adults from 39 Japanese municipalities were enrolled. PRIMARY OUTCOME MEASURE: The primary outcome was the PPSV23 vaccination among the Japanese older adults aged 65 years or older who did not have physical or cognitive disabilities. RESULTS: After adjusting for municipality-, community-, individual-levels effects with multiple imputation, 137 075 individuals who participated in one/more of the civic participation (participation of social groups), social cohesion (social tie), or reciprocity (mutual exchange of social support) were significantly associated with more vaccinations than those without the three social capitals among the 137 075 older adults (13.0% (95% CI 11.0% to 14.9%), 5.0% (95% CI 2.4% to 7.6%) or 33.9% (95% CI23.6% to 44.2%) increase, respectively, p>0.001 for all). The rich (≥+1 SD) community-level civic participation was significantly associated with 3.4% increase [95% CI 0.02% to 6.78%, p<0.05] of the PPSV23 vaccination among the older adults compared to those with the poor or standard one. CONCLUSIONS: Older adults with one/more of the three social capitals at the both levels received more PPSV23 vaccinations than those without those social capitals. Therefore, fostering of those social capitals may improve the inequality of the PPSV23 vaccination rate among older adults in each municipality.

    DOI: 10.1136/bmjopen-2020-043723

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  • Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study). International journal

    Kousuke Iwai-Saito, Yugo Shobugawa, Jun Aida, Katsunori Kondo

    Scientific reports   11 ( 1 )   7966 - 7966   2021.4

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    Pneumonia is a leading cause of mortality among older adults worldwide. Recently, several studies reported that frailty was associated with mortality among older adults hospitalized due to respiratory infectious diseases, including pneumonia. However, it is unknown whether frailty is associated with susceptibility to and severity of pneumonia in functionally-independent community-dwelling older adults. In this study, we examined whether frailty increased the susceptibility to pneumonia and hospitalization in older adults. We used cross-sectional data from the Japan Gerontological Evaluation Study; the data was collected by using mail-based, self-reported questionnaires from 177,991 functionally-independent community-dwelling older adults aged ≥ 65 years. Our results showed that frailty was significantly associated with both occurrence of and hospitalization due to pneumonia after adjustments with covariates; (Preference ratio {PR} 1.92, 95% confidence interval {95% CI} [1.66-2.22] and PR 1.80, 95% CI [1.42-2.28], respectively, p < 0.001 for the both). Pre-frailty was associated only with the occurrence of pneumonia. Besides, the instrumental activity of daily living, physical strength, nutrition status, oral function, homeboundness, and depression status in frail older adults were associated with either or both occurrence of and hospitalization due to pneumonia. Our results suggest that frailty influenced the susceptibility to and severity of pneumonia in older adults.

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  • Objectively measured intensity-specific physical activity and hippocampal volume among community-dwelling older adults.

    Masaki Machida, Tomoko Takamiya, Shiho Amagasa, Hiroshi Murayama, Takeo Fujiwara, Yuko Odagiri, Hiroyuki Kikuchi, Noritoshi Fukushima, Mitsuo Kouno, Yu Saito, Fumitoshi Yoshimine, Shigeru Inoue, Yugo Shobugawa

    Journal of epidemiology   32 ( 11 )   489 - 495   2021.3

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    BACKGROUND: The hippocampus is a brain structure important for memory and cognitive function. Physical activity may help prevent hippocampal atrophy. However, few studies have measured sedentary behavior (SB) and intensity-specific physical activity using an accelerometer. This study aimed to examine the cross-sectional associations of objectively-determined SB, light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) measured by an accelerometer with hippocampal volume among community-dwelling older adults using compositional data analysis (CoDa) approach. METHODS: This cross-sectional study was part of the Neuron to Environmental Impact across Generations (NEIGE) study. A randomly recruited sample of 485 Japanese older adults (47% male; aged 65-84 years) wore tri-axial accelerometers (Omron Healthcare) for seven consecutive days in 2017. Hippocampal volume was measured with magnetic resonance imaging and the left and right hippocampal volumes were automatically segmented using FreeSurfer software. Associations of sedentary and physically active behaviors with hippocampal volume were examined with compositional linear regression analysis based on isometric log-ratio transformations of time use adjusted for potential confounding factors. RESULTS: The relative proportion of time spent in MVPA, compared to the other two activities, was significantly positively associated with right hippocampal volume (β: 57.1, p-value = 0.027).However, no association existed between higher proportions of MVPA and left hippocampal volume, or between proportions of SB or LPA with either left or right hippocampal volumes. CONCLUSIONS: The proportion of time spent in MVPA, relative to the other two activities, was significantly positively associated with right hippocampal volume. MVPA may be beneficial for maintaining hippocampal volume.

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  • Rural–Urban Differences in the Factors Affecting Depressive Symptoms among Older Adults of Two Regions in Myanmar

    Yuri Sasaki, Yugo Shobugawa, Ikuma Nozaki, Daisuke Takagi, Yuiko Nagamine, Masafumi Funato, Yuki Chihara, Yuki Shirakura, Kay Thi Lwin, Poe Ei Zin, Thae Zarchi Bo, Tomofumi Sone, Hla Hla Win

    International Journal of Environmental Research and Public Health   18 ( 6 )   2818 - 2818   2021.3

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    The aim of the study was to investigate rural–urban differences in depressive symptoms in terms of the risk factors among older adults of two regions in Myanmar to provide appropriate intervention for depression depending on local characteristics. This cross-sectional study, conducted between September and December, 2018, used a multistage sampling method to recruit participants from the two regions, for face-to-face interviews. Depressive symptoms were assessed using the 15-item version of the Geriatric Depression Scale (GDS). Depressive symptoms were positively associated with living in rural areas (B = 0.42; 95% confidence interval (CI): 0.12,0.72), female (B = 0.55; 95% CI: 0.31,0.79), illness during the preceding year (B = 0.68; 95% CI: 0.45,0.91) and non-Buddhist religion (B = 0.57; 95% CI: 0.001,1.15) and protectively associated with education to middle school level or higher (B = −0.61; 95% CI: −0.94, −0.28) and the frequency of visits to religious facilities (B = −0.20; 95% CI: −0.30, −0.10). In women in urban areas, depressive symptoms were positively associated with illness during the preceding year (B = 0.78; 95% CI: 0.36, 1.20) and protectively associated with education to middle school level or higher (B = −0.67; 95% CI: −1.23, −0.11), middle or high wealth index (B = −0.92; 95% CI: −1.59, −0.25) and the frequency of visits to religious facilities (B = −0.20; 95% CI: −0.38, −0.03). In men in rural areas, illness during the preceding year was positively associated with depressive symptoms (B = 0.87; 95% CI: 0.33, 1.42). In women in rural areas, depressive symptoms were positively associated with illness during the preceding year (B = 0.83; 95% CI: 0.36, 1.30) and protectively associated with primary education (B = −0.62; 95% CI: −1.12, −0.12) and the frequency of visits to religious facilities (B = −0.44; 95% CI: −0.68, −0.21). Religion and wealth could have different levels of association with depression between older adults in the urban and rural areas and men and women. Interventions for depression in older adults should consider regional and gender differences in the roles of religion and wealth in Myanmar.

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  • Familial Clusters of Coronavirus Disease in 10 Prefectures, Japan, February-May 2020. International journal

    Reiko Miyahara, Naho Tsuchiya, Ikkoh Yasuda, Yura K Ko, Yuki Furuse, Eiichiro Sando, Shohei Nagata, Tadatsugu Imamura, Mayuko Saito, Konosuke Morimoto, Takeaki Imamura, Yugo Shobugawa, Hiroshi Nishiura, Motoi Suzuki, Hitoshi Oshitani

    Emerging infectious diseases   27 ( 3 )   915 - 918   2021.3

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    The overall coronavirus disease secondary attack rate (SAR) in family members was 19.0% in 10 prefectures of Japan during February 22-May 31, 2020. The SAR was lower for primary cases diagnosed early, within 2 days after symptom onset. The SAR of asymptomatic primary cases was 11.8%.

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  • Association of pneumococcal and influenza vaccination with patient-physician communication in older adults: A nationwide cross-sectional study from the JAGES 2016.

    Koryu Sato, Naoki Kondo, Chiyoe Murata, Yugo Shobugawa, Kousuke Saito, Katsunori Kondo

    Journal of epidemiology   2021.2

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    BACKGROUND: Increasing the coverage of vaccinations recommended by the World Health Organization in the older adult population is an urgent issue, especially in the context of avoiding co-epidemics during the current coronavirus disease 2019 crisis. The aim of this study was to examine factors associated with the quality of perceived patient-physician communication and whether this variable was associated with increased odds of vaccination. METHODS: We used cross-sectional data from the Japan Gerontological Evaluation Study conducted from October 2016 to January 2017. The participants were 22,253 physically and cognitively independent individuals aged 65 or older living in 39 municipalities in Japan. Multilevel logit models were used to estimate the odds of vaccination. RESULTS: Among the participants, 40.0% and 58.8% had received pneumococcal and influenza vaccinations as per the recommended schedule, respectively. People with low educational levels were more likely to have a family physician but rate their experience in asking questions lower than those with higher educational levels. Having a family physician and high rating for physicians' listening attitude were positively associated with increased odds of pneumococcal and influenza vaccinations. High rating for patients' questioning attitude and shared decision-making, compared to an ambiguous attitude toward medical decision-making, were positively associated with increased odds of pneumococcal vaccination. CONCLUSION: The results suggest that promotion of having a family physician, better patient-physician communication, and shared decision-making may encourage older adults to undergo recommended vaccinations.

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  • Factors associated with the need for assistance among the elderly in Malaysia

    Nazarudin Safian, Shamsul Azhar Shah, Juliana Mansor, Zulkefley Mohammad, Siti Rohani Nurumal, Wan Abdul Hannan Wan Ibadullah, Saharuddin Ahmad, Yugo Shobugawa

    International Journal of Environmental Research and Public Health   18 ( 2 )   1 - 14   2021.1

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  • Associations of older adults' physical activity and bout-specific sedentary time with frailty status: Compositional analyses from the NEIGE study

    Hiroyuki Kikuchi, Shigeru Inoue, Shiho Amagasa, Noritoshi Fukushima, Masaki Machida, Hiroshi Murayama, Takeo Fujiwara, Sebastien Chastin, Neville Owen, Yugo Shobugawa

    Experimental Gerontology   143   111149 - 111149   2021.1

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  • Association between depressive symptoms and objective/subjective socioeconomic status among older adults of two regions in Myanmar. International journal

    Yuri Sasaki, Yugo Shobugawa, Ikuma Nozaki, Daisuke Takagi, Yuiko Nagamine, Masafumi Funato, Yuki Chihara, Yuki Shirakura, Kay Thi Lwin, Poe Ei Zin, Thae Zarchi Bo, Tomofumi Sone, Hla Hla Win

    PloS one   16 ( 1 )   e0245489   2021

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    Low objective socioeconomic status (SES) has been correlated with poor physical and mental health among older adults. Some studies suggest that subjective SES is also important for ensuring sound physical and mental health among older adults. However, few studies have been conducted on the impact of both objective and subjective SES on mental health among older adults. This study examines whether objective or subjective SES is associated with depressive symptoms in older adults in Myanmar. This cross-sectional study, conducted between September and December, 2018, used a multistage sampling method to recruit participants from two regions of Myanmar, for face-to-face interviews. The Geriatric Depression Scale (GDS) was used to evaluate the depressive symptoms. Participants were classified as having no depressive symptom (GDS score <5) and having depressive symptoms (GDS score ≥5). Objective and subjective SES were assessed using the wealth index and asking participants a multiple-choice question about their current financial situation, respectively. The relationship between objective/subjective SES and depressive symptoms was examined using a multivariable logistic regression analysis. The mean age of the 1,186 participants aged 60 years and above was 69.7 (SD: 7.3), and 706 (59.5%) were female. Among them, 265 (22.3%) had depressive symptoms. After adjusting for objective SES and other covariates, only low subjective SES was positively associated with depressive symptoms (adjusted odds ratio, AOR: 4.18, 95% confidence interval, CI: 2.98-5.87). This association was stronger among participants in the rural areas (urban areas, AOR: 2.10, 95% CI: 1.08-4.05; rural areas, AOR: 5.65, 95% CI: 3.69-8.64). Subjective SES has a stronger association with depressive symptoms than objective SES, among older adults of the two regions in Myanmar, especially in the rural areas. Interventions for depression in older adults should consider regional differences in the context of subjective SES by reducing socioeconomic disparities among the communities.

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  • Leisure Activity Variety and Brain Volume Among Community-Dwelling Older Adults: Analysis of the Neuron to Environmental Impact Across Generations Study Data. International journal

    Ai Iizuka, Hiroshi Murayama, Masaki Machida, Shiho Amagasa, Shigeru Inoue, Takeo Fujiwara, Yugo Shobugawa

    Frontiers in aging neuroscience   13   758562 - 758562   2021

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    Background: Recent findings indicate that leisure activity (LA) delays cognitive decline and reduces the risk of dementia. However, the association between LA and brain volume remains unclear. This study aimed to examine the association between LA variety and brain volume with a focus on the hippocampus and gray matter. Methods: Data were obtained from the baseline survey of the Neuron to Environmental Impact across Generations study, which had targeted community-dwelling older adults living in Niigata, Japan. We divided LAs into 10 categories, and counted the number of categories of activities in which the participants engaged. We classified them as follows: 0 (i.e., no activity), 1, 2, or ≥ 3 types. Brain volume was assessed through magnetic resonance imaging, and hippocampal and gray matter volumes were ascertained. Results: The sample size was 482. Multiple linear regression analysis showed that hippocampal and gray matter volumes were significantly greater among participants with ≥ 3 types of LAs than among their no-activity counterparts. Hippocampal volume was significantly greater among those who engaged in one type of LA than among those who engaged in no such activity. Sex-stratified analysis revealed that hippocampal volumes were significantly greater among males who engaged in ≥ 3 types of LAs and one type of LA. However, no such association was found among females. Conclusion: The present findings suggest that engaging in a wide range of LAs is related to hippocampal and gray matter volumes. Furthermore, there was a sex difference in the association between LA variety and brain volume.

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  • ミャンマーの高齢者の主観的及び客観的な社会経済状況とうつ傾向の関連

    佐々木 由理, 菖蒲川 由郷, 野崎 威功真, 高木 大資, 長嶺 由衣子, 船戸 真史, 茅原 祐紀, 曽根 智史, ウィン・ララ

    グローバルヘルス合同大会プログラム・抄録集   2020   147 - 147   2020.11

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  • Duration of fever and symptoms in children after treatment with baloxavir marboxil and oseltamivir during the 2018–2019 season and detection of variant influenza a viruses with polymerase acidic subunit substitutions Reviewed International journal

    Reiko Saito, Hidekazu Osada, Keita Wagatsuma, Irina Chon, Isamu Sato, Takashi Kawashima, Tadashi Saito, Naoki Kodo, Yasuhiko Ono, Yasushi Shimada, Wint Wint Phyu, Yugo Shobugawa

    Antiviral Research   183   104951 - 104951   2020.11

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  • ミャンマーの都市部と農村部の男女高齢者のうつリスク要因の相違

    佐々木 由理, 菖蒲川 由郷, 野崎 威功真, 高木 大資, 長嶺 由衣子, 船戸 真史, 白倉 悠企, 曽根 智史

    日本公衆衛生学会総会抄録集   79回   296 - 296   2020.10

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  • Cohort profile: healthy and active ageing in Myanmar (JAGES in Myanmar 2018): a prospective population-based cohort study of the long-term care risks and health status of older adults in Myanmar

    Hla Hla Win, Than Win Nyunt, Kay Thi Lwin, Poe Ei Zin, Ikuma Nozaki, Thae Zarchi Bo, Yuri Sasaki, Daisuke Takagi, Yuiko Nagamine, Yugo Shobugawa

    BMJ Open   10 ( 10 )   e042877 - e042877   2020.10

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    <sec><title>Purpose</title>Myanmar is rapidly ageing. It is important to understand the current condition of older adults in the country. To obtain such information, we conducted home-visit surveys to collect data for evaluating social determinants of health on older adults in Yangon (representative of an urban) and Bago (representative of a rural) regions of Myanmar.

    </sec><sec><title>Participants</title>Overall, 1200 individuals aged 60 years or older and who were not bedridden or had severe dementia (defined as an Abbreviated Mental Test score ≤6) were recruited from Yangon and Bago in 2018. A population-proportionate random-sampling method was used for recruitment.

    </sec><sec><title>Findings to date</title>Overall, 600 individuals from Yangon (222 men; 378 women) and 600 from Bago (261 men; 339 women) were surveyed. The average age of Yangon-based men and women was 69.4±7.6 and 69.4±7.3 years; in Bago, this was 69.2±7.1 and 70.6±7.5 years, respectively. Compared to their Yangon-based counterparts, Bago-based respondents showed significantly lower socioeconomic status and more commonly reported poor self-rated health (Bago-based men: 32.2%, women: 42.5%; Yangon: 10.8% and 24.1%, respectively). Meanwhile, some Yangon-based respondents rarely met friends (men: 17.1%, women: 27.8%), and Yangon-based respondents scored higher for instrumental activities of daily living and body mass index when compared to their Bago-based counterparts. For both regions, women showed higher physical-function decline (Yangon-based women: 40.7%, men: 17.1%; Bago: 46.3% and 23.8%, respectively) and cognitive-function decline (Yangon: 34.1% and 10.4%, respectively; Bago: 53.4% and 22.2%, respectively). Being homebound was more common in urban areas (urban-based men: 11.3%, rural-based men: 2.3%; urban-based women: 13.0%, rural-based women: 4.7%, respectively).

    </sec><sec><title>Future plans</title>A follow-up survey is scheduled for 2021. This will afford longitudinal data collection concerning mortality, becoming bedridden, and developing dementia and long-term care-related diseases. This will allow us to calculate long-term care risks for older adults in Myanmar.

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  • Clusters of coronavirus disease in communities, Japan, January-April 2020 Reviewed International journal

    Yuki Furuse, Eiichiro Sando, Naho Tsuchiya, Reiko Miyahara, Ikkoh Yasuda, Yura K.Ko, Mayuko Saito, Konosuke Morimoto, Takeaki Imamura, Yugo Shobugawa, Shohei Nagata, Kazuaki Jindai, Tadatsugu Imamura, Tomimasa Sunagawa, Motoi Suzuki, Hiroshi Nishiura, Hitoshi Oshitani

    Emerging Infectious Diseases   26 ( 9 )   2176 - 2179   2020.9

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  • Changes in rural older adults' sedentary and physically-active behaviors between a non-snowfall and a snowfall season: Compositional analysis from the NEIGE study Reviewed International journal

    Shiho Amagasa, Shigeru Inoue, Hiroshi Murayama, Takeo Fujiwara, Hiroyuki Kikuchi, Noritoshi Fukushima, Masaki MacHida, Sebastien Chastin, Neville Owen, Yugo Shobugawa

    BMC Public Health   20 ( 1 )   1248 - 1248   2020.8

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  • Factors contributing to symptom duration and viral reduction in outpatient children with respiratory syncytial virus infection Reviewed International journal

    Takeshi Utsunomiya, Akinobu Hibino, Kiyosu Taniguchi, Takao Nagai, Naruo Saito, Ikumi Tanabe, Takashi Odagiri, Yugo Shobugawa, Akira Kaneko, Reiko Saito

    Pediatric Infectious Disease Journal   39 ( 8 )   678 - 683   2020.8

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  • Sekentei as a socio-cultural determinant of cognitive function among older japanese people: Findings from the neige study Reviewed International journal

    Hiroshi Murayama, Shigeru Inoue, Takeo Fujiwara, Naoki Fukui, Yuichi Yokoyama, Yugo Shobugawa

    International Journal of Environmental Research and Public Health   17 ( 12 )   1 - 11   2020.6

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  • Changes in the incidence of cervical lesions owing to the development of rheumatoid arthritis treatment and the impact of cervical lesions on patients’ quality of life Reviewed International journal

    Osamu Morita, Kazuto Miura, Toru Hirano, Kei Watanabe, Tadamasa Hanyu, Takahiro Netsu, Naoki Kondo, Junichi Fujisawa, Takako Saeki, Tomoyuki Ito, Yugo Shobugawa, Kei Yoshida, Naoto Endo

    Modern Rheumatology   30 ( 3 )   495 - 501   2020.5

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    DOI: 10.1080/14397595.2019.1621428

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  • Association between neighborhood environment and quality of sleep in older adult residents living in japan: The jages 2010 cross-sectional study Reviewed International journal

    Michiko Watanabe, Yugo Shobugawa, Atsushi Tashiro, Asami Ota, Tsubasa Suzuki, Tomoko Tsubokawa, Katsunori Kondo, Reiko Saito

    International Journal of Environmental Research and Public Health   17 ( 4 )   2020.2

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  • Cohort profile of the neige study in Tokamachi City, Japan Reviewed

    Yugo Shobugawa, Hiroshi Murayama, Takeo Fujiwara, Shigeru Inoue

    Journal of Epidemiology   30 ( 7 )   281 - 287   2020

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  • Laboratory and epidemiology communications epidemiology of covid-19 outbreak in japan, from january–march 2020 Reviewed

    Yuki Furuse, Yura K. Ko, Mayuko Saito, Yugo Shobugawa, Kazuaki Jindai, Tomoya Saito, Hiroshi Nishiura, Tomimasa Sunagawa, Motoi Suzuki, Hitoshi Oshitani

    Japanese Journal of Infectious Diseases   73 ( 5 )   391 - 393   2020

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  • Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza Reviewed International journal

    Momoko Mawatari, Reiko Saito, Akinobu Hibino, Hiroki Kondo, Ren Yagami, Takashi Odagiri, Ikumi Tanabe, Yugo Shobugawa

    PLoS ONE   14 ( 11 )   e0224683   2019.11

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  • Associations of sedentary and physically-active behaviors with cognitive-function decline in community-dwelling older adults: compositional data analysis from the NEIGE study. Reviewed

    Shiho Amagasa, Shigeru Inoue, Hiroshi Murayama, Takeo Fujiwara, Hiroyuki Kikuchi, Noritoshi Fukushima, Masaki Machida, Sebastien Chastin, Neville Owen, Yugo Shobugawa

    Journal of epidemiology   30 ( 11 )   503 - 508   2019.10

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    BACKGROUND: Physical activity can help to protect against cognitive decline in older adults. However, little is known about the potential combined relationships of time spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with indices of cognitive health. We examined the cross-sectional associations of objectively-determined sedentary and physically-active behaviors with an indicator of cognitive function decline (CFD) in older adults. METHODS: A randomly-recruited sample of 511 Japanese older adults (47% male; aged 65-84 years) wore a tri-axial accelerometer (HJA-750C, Omron) for seven consecutive days in 2017. Cognitive function was assessed by interviewers using the Japanese version of Mini-Mental State Examination, with a score of ≤23 indicating CFD. Associations of sedentary and physically-active behaviors with CFD were examined using a compositional logistic regression analysis based on isometric log-ratio transformations of time use, adjusting for potential confounders. RESULTS: Forty one (9.4%) of the participants had an indication of CFD. Activity compositions differed significantly between CFD and normal cognitive function (NCF); the proportion of time spent in MVPA was 39.1% lower, relatively to the overall mean composition in those with CFD, and was 5.3% higher in those with NCF. There was a significant beneficial association of having a higher proportion of MVPA relative to other activities with CFD. LPA and SB were not associated with CFD when models were corrected for time spent in all activity behaviors. CONCLUSIONS: Larger relative contribution of MVPA was favorably associated with an indicator of CFD in older adults.

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  • Sekentei and objectively-measured physical activity among older Japanese people: A cross-sectional analysis from the NEIGE study Reviewed International journal

    Hiroshi Murayama, Shiho Amagasa, Shigeru Inoue, Takeo Fujiwara, Yugo Shobugawa

    BMC Public Health   19 ( 1 )   1331 - 1331   2019.10

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  • Compositional Associations Of Objectively Measured Activities With Declined Cognitive Function In Older Adults: NEIGE Study Reviewed

    Shiho Amagasa, Shigeru Inoue, Hiroshi Murayama, Takeo Fujiwara, Hiroyuki Kikuchi, Noritoshi Fukushima, Masaki Machida, Sebastien Chastin, Yugo Shobugawa

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   51 ( 6 )   214 - 214   2019.6

  • Prevalence of and factors associated with dysfunctional low back pain in patients with rheumatoid arthritis. Reviewed International journal

    Kazuto Miura, Osamu Morita, Toru Hirano, Kei Watanabe, Jun'ichi Fujisawa, Naoki Kondo, Takahiro Netsu, Tadamasa Hanyu, Yugo Shobugawa, Naoto Endo

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society   28 ( 5 )   976 - 982   2019.5

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  • Incidence of four major types of osteoporotic fragility fractures among elderly individuals in Sado, Japan, in 2015. Reviewed

    Norio Imai, Naoto Endo, Yugo Shobugawa, Takeo Oinuma, Yasuhito Takahashi, Kazuaki Suzuki, Yuya Ishikawa, Tatsuo Makino, Hayato Suzuki, Dai Miyasaka, Mayumi Sakuma

    Journal of bone and mineral metabolism   37 ( 3 )   484 - 490   2019.5

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  • Validity of the Japanese Version of the Quick Mild Cognitive Impairment . Reviewed

    Morita A, O'Caoimh R, Murayama H, Molloy DW, Inoue S, Shobugawa Y, Fujiwara T

    International Journal of Environmental Research and Public Health   16 ( 6 )   2019.5

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    Early detection of dementia provides opportunities for interventions that could delay or prevent its progression. We developed the Japanese version of the Quick Mild Cognitive Impairment (Qmci-J) screen, which is a performance-based, easy-to-use, valid and reliable short cognitive screening instrument, and then we examined its validity. Community-dwelling adults aged 65⁻84 in Niigata prefecture, Japan, were concurrently administered the Qmci-J and the Japanese version of the standardized Mini-Mental State Examination (sMMSE-J). Mild cognitive impairment (MCI) and dementia were categorized using established and age-adjusted sMMSE-J cut-offs. The sample (n = 526) included 52 (9.9%) participants with suspected dementia, 123 (23.4%) with suspected MCI and 351 with likely normal cognition. The Qmci-J showed moderate positive correlation with the sMMSE-J (r = 0.49, p &lt; 0.001) and moderate discrimination for predicting suspected cognitive impairment (MCI/dementia) based on sMMSE-J cut-offs, area under curve: 0.74, (95%CI: 0.70⁻0.79), improving to 0.76 (95%CI: 0.72 to 0.81) after adjusting for age. At a cut-off of 60/61/100, the Qmci-J had a 73% sensitivity, 68% specificity, 53% positi

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  • Validity of the Japanese Version of the Quick Mild Cognitive Impairment Screen. Reviewed International journal

    Ayako Morita, Rónán O'Caoimh, Hiroshi Murayama, D William Molloy, Shigeru Inoue, Yugo Shobugawa, Takeo Fujiwara

    International journal of environmental research and public health   16 ( 6 )   2019.3

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  • Association of early social environment with the onset of pediatric Kawasaki disease. Reviewed International journal

    Takeo Fujiwara, Yugo Shobugawa, Kenji Matsumoto, Ichiro Kawachi

    Annals of epidemiology   29   74 - 80   2019.1

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  • Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010-2015. Reviewed International journal

    Khin Thu Zar Htwe, Clyde Dapat, Yugo Shobugawa, Takashi Odagiri, Akinobu Hibino, Hiroki Kondo, Ren Yagami, Takehiko Saito, Nobuhiro Takemae, Tsutomu Tamura, Hisami Watanabe, Yadanar Kyaw, Nay Lin, Yi Yi Myint, Htay Htay Tin, Win Thein, Latt Latt Kyaw, Pan Ei Soe, Makoto Naito, Hassan Zaraket, Hiroshi Suzuki, Takashi Abe, Reiko Saito

    PloS one   14 ( 1 )   e0210550   2019

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  • A decrease in the number and incidence of osteoporotic hip fractures among elderly individuals in Niigata, Japan, from 2010 to 2015 Reviewed

    Norio Imai, Naoto Endo, Yugo Shobugawa, Shinya Ibuchi, Hayato Suzuki, Dai Miyasaka, Mayumi Sakuma

    JOURNAL OF BONE AND MINERAL METABOLISM   36 ( 5 )   573 - 579   2018.9

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  • Neuraminidase inhibitor susceptibility and evolutionary analysis of human influenza B isolates from three Asian countries during 2012-2015 Reviewed International journal

    Akinobu Hibino, Elie Massaad, Hiroki Kondo, Reiko Saito, Takashi Odagiri, Nobuhiro Takemae, Ryota Tsunekuni, Takehiko Saito, Yadanar Kyaw, Nay Lin, Yi Yi Myint, Htay Htay Tin, Nguyen Le Khanh Hang, Le Quynh Mai, Ren Yagami, Yugo Shobugawa, Tommy Lam, Hassan Zaraket

    INFECTION GENETICS AND EVOLUTION   62   27 - 33   2018.8

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  • Social participation and risk of influenza infection in older adults: A cross-sectional study Reviewed International journal

    Yugo Shobugawa, Takeo Fujiwara, Atsushi Tashiro, Reiko Saito, Katsunori Kondo

    BMJ Open   8 ( 1 )   e016876   2018.1

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  • Molecular epidemiology of human respiratory syncytial virus among children in Japan during three seasons and hospitalization risk of genotype ON1 Reviewed International journal

    Akinobu Hibino, Reiko Saito, Kiyosu Taniguchi, Hassan Zaraket, Yugo Shobugawa, Tamano Matsui, Hiroshi Suzuki

    PLOS ONE   13 ( 1 )   e0192085   2018.1

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  • Is a hilly neighborhood environment associated with diabetes mellitus among older people? Results from the JAGES 2010 study Reviewed

    Takeo Fujiwara, Iseki Takamoto, Airi Amemiya, Masamichi Hanazato, Norimichi Suzuki, Yuiko Nagamine, Yuri Sasaki, Yukako Tani, Aid Yazawa, Yosuke Inoue, Kokoro Shirai, Yugo Shobugawa, Naoki Kondo, Katsunori Kondo

    SOCIAL SCIENCE & MEDICINE   182   45 - 51   2017.6

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  • Is a hilly neighborhood environment associated with diabetes mellitus among older people? Results from the JAGES 2010 study. Reviewed International journal

    Takeo Fujiwara, Iseki Takamoto, Airi Amemiya, Masamichi Hanazato, Norimichi Suzuki, Yuiko Nagamine, Yuri Sasaki, Yukako Tani, Aki Yazawa, Yosuke Inoue, Kokoro Shirai, Yugo Shobugawa, Naoki Kondo, Katsunori Kondo

    Social science & medicine (1982)   182   45 - 51   2017.6

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    BACKGROUND: Although living in a hilly environment may promote muscular activity in the daily lives of residents, and such activity may prevent diabetes mellitus, few studies have focused on the impact of living in a hilly environment on diabetes mellitus. The purpose of this study was to investigate the impact of a hilly neighborhood environment on DM in older people. METHODS: We used data from the Japan Gerontological Evaluation Study, a population-based, cross-sectional study of individuals aged 65 or older without long-term care needs in Japan, which was conducted in 2010. A total of 8904 participants in 46 neighborhoods had responded to the questionnaire and undergone a health check. Diabetes mellitus was diagnosed as HbA1c ≥ 6.5% and those undergoing treatment for diabetes mellitus. Poorly controlled diabetes mellitus was diagnosed in those without other chronic diseases who had an HbA1c > 7.5%, and in those with other chronic diseases if their HbA1c was >8.0%. Neighborhood environment was evaluated based on the percentage of positive responses in the questionnaire and geographical information system data. A multilevel analysis was performed, adjusted for individual-level risk factors. Furthermore, sensitivity analysis was conducted for those who were undergoing treatment for diabetes mellitus (n = 1007). RESULTS: After adjustment for other physical environmental and individual covariates, a 1 interquartile range increase (1.48°) in slope in the neighborhood decreased the risk of poorly controlled diabetes mellitus by 18% (odds ratio [OR]: 0.82, 95% confidence interval [CI]: 0.70-0.97). Sensitivity analysis confirmed that larger slopes in the neighborhood showed a significant protective effect against diabetes mellitus among those who were undergoing treatment for diabetes mellitus (OR: 0.73, 95% CI: 0.59-0.90). CONCLUSION: A hilly neighborhood environment was not associated with diabetes mellitus, but was protective against poorly controlled diabetes mellitus.

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  • Assessment and Visualization of Risk Factor for Disease and Care in Elderly Reviewed

    Yugo Shobugawa, Atsushi Tashiro, Tsubasa Suzuki, Reiko Saito

    Journal of Niigata City Medical Assosiation   47 ( 554 )   2 - 22   2017.5

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  • Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection Reviewed International journal

    Yuki Ichikawa, Satoru Joshita, Takeji Umemura, Yugo Shobugawa, Yoko Usami, Soichiro Shibata, Tomoo Yamazaki, Naoyuki Fujimori, Michiharu Komatsu, Akihiro Matsumoto, Eiji Tanaka

    HEPATOLOGY RESEARCH   47 ( 2 )   226 - 233   2017.2

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  • Association between income inequality and dental status in Japanese older adults: Analysis of data from JAGES2013

    TASHIRO Atsushi, AIDA Jun, SHOBUGAWA Yugo, FUJIYAMA Yuki, YAMAMOTO Tatsuo, SAITO Reiko, KONDO Katsunori

    Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)   64 ( 4 )   190 - 196   2017

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    <p><b>Objectives</b> Personal income affects dental status in older people. However, the impact of income inequality on dental status at the community level (junior high school district) is unclear. The purpose of this study was to examine the association between dental status and community level income inequity after adjust for individual socio-economic status in Japanese older adults, and to verify the relative income hypothesis, also known as the Wilkinson hypothesis.</p><p><b>Methods</b> We used data from the Japan Gerontological Evaluation Study (JAGES) conducted in Niigata city. JAGES is a postal survey of functionally independent adults aged 65 years or older. We enrolled 4,983 respondents (response rate 62.3%) and used data on 3,980 of them after excluding incomplete data. We evaluated health condition and socio-economic status using questionnaires. The Gini coefficient, as an indicator of income inequality, was calculated by junior high school district (57 districts) based on the data from the questionnaire. Additionally, the Pearson's coefficient of correlation was calculated to evaluate the association between the mean number of remaining teeth and the community level Gini coefficient. Then we evaluated the mean number of remaining teeth among the groups stratified by the Gini coefficient conditions. Next, we conducted a multilevel analysis using an ordinal logistic regression model. The number of remaining teeth was set as the dependent variable, while sex, age, household size, education, smoking status, diabetes treatment, current living conditions, and equivalent income were used as independent variables at the individual level. The Gini coefficient and average equivalent income in the junior high school district were used as independent variables at the community level.</p><p><b>Results</b> The Pearson's correlation coefficient for the relationship between the Gini coefficient and the mean number of remaining teeth in the junior high school district was −0.44 (<i>P</i><0.01). Wider income disparity area (Gini coefficient≧0.35) revealed a significantly small number of remaining teeth (<i>P</i><0.001). The multilevel analysis showed that a higher Gini coefficient and a lower average equivalent income at the community level were significantly associated with a lower number of remaining teeth, and with educational attainment, smoking status, current living conditions, and equivalent income at the individual level, after adjusting for sex and age. On the other hand, educational attainment at the individual level, and average equivalent income at the community level were not significant factors after adjusting for all individual level variables.</p><p><b>Conclusion</b> This study showed that, in addition to individual socio-economic status, income inequality at the community level was significantly associated with number of remaining teeth in Japanese older adults. Although the precise mechanism of this association is still unclear, our result supports the relative income hypothesis.</p>

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  • Development of a Portable Gamma-ray Survey System for the Measurement of Air Dose Rates Reviewed

    Jun Goto, Yugo Shobugawa, Yoh Kawano, Yoshihiro Amaya, Takuji Izumikawa, Yoshinori Katsuragi, Tomohiro Shiiya, Tsubasa Suzuki, Takeshi Takahashi, Toshihiro Takahashi, Hidenori Yoshida, Makoto Naito

    Proceedings of International Symposium on Radiation Detectors and Their Uses (ISRD2016)   2016.11

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  • Effect of herd size on subclinical infection of swine in Vietnam with influenza A viruses Reviewed International journal

    Nobuhiro Takemae, Yugo Shobugawa, Phuong Thanh Nguyen, Tung Nguyen, Tien Ngoc Nguyen, Thanh Long To, Phuong Duy Thai, Tho Dang Nguyen, Duy Thanh Nguyen, Dung Kim Nguyen, Hoa Thi Do, Thi Quynh Anh Le, Phan Truong Hua, Hung Van Vo, Diep Thi Nguyen, Dang Hoang Nguyen, Yuko Uchida, Reiko Saito, Takehiko Saito

    BMC Veterinary Research   12 ( 1 )   227 - 227   2016.10

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  • Sensing Space: Augmenting Scientific Data with Spatial Ethnography Reviewed

    Yoh Kawano, Arfakhashad Munaim, Jun Goto, Yugo Shobugawa, Makoto Naito

    GeoHumanities   2 ( 2 )   485 - 508   2016.7

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  • Serum Albumin Levels and Economic Status in Japanese Older Adults Reviewed International journal

    Asami Ota, Naoki Kondo, Nobuko Murayama, Naohito Tanabe, Yugo Shobugawa, Katsunori Kondo

    PLOS ONE   11 ( 6 )   e0155022   2016.6

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  • Full Genome Characterization of Human Influenza A/H3N2 Isolates from Asian Countries Reveals a Rare Amantadine Resistance-Conferring Mutation and Novel PB1-F2 Polymorphisms Reviewed International journal

    Hassan Zaraket, Hiroki Kondo, Akinobu Hibino, Ren Yagami, Takashi Odagiri, Nobuhiro Takemae, Ryota Tsunekuni, Takehiko Saito, Yi Yi Myint, Yadanar Kyaw, Khin Yi Oo, Htay Htay Tin, Nay Lin, Nguyen Phuong Anh, Nguyen Le Khanh Hang, Le Quynh Mai, Mohd R. Hassan, Yugo Shobugawa, Julian Tang, Ghassan Dbaibo, Reiko Saito

    FRONTIERS IN MICROBIOLOGY   7   262 - 262   2016.3

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  • Influenza Virus Shedding in Laninamivir-Treated Children upon Returning to School Reviewed

    Hiroki Kondo, Yugo Shobugawa, Akinobu Hibino, Ren Yagami, Clyde Dapat, Minoru Okazaki, Taketo Otsuka, Koyata Fujii, Mohd Rohaizat Hassan, Reiko Saito

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   238 ( 2 )   113 - 121   2016.2

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  • 肺炎球菌ワクチン接種率の地域差と背景要因

    田代敦志, 菖蒲川由郷, 齋藤玲子, 近藤克則

    厚生の指標   63 ( 1 )   1 - 6   2016.1

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  • Primary percutaneous coronary intervention and bleeding risk in the era of drug-eluting stent: a long-term cohort study Reviewed

    Keiichi Tsuchida, Ryutaro Ikegami, Michio Sato, Yugo Shobugawa, Takeshi Okubo, Toshiaki Yano, Komei Tanaka, Tsuyoshi Kobayashi, Yukio Hosaka, Kazuyuki Ozaki, Kazuyoshi Takahashi, Tsutomu Miida, Hirotaka Oda

    CARDIOVASCULAR INTERVENTION AND THERAPEUTICS   30 ( 3 )   216 - 226   2015.7

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  • The spatial diffusion of norovirus epidemics over three seasons in Tokyo Reviewed

    S. Inaida, Y. Shobugawa, S. Matsuno, R. Saito, H. Suzuki

    EPIDEMIOLOGY AND INFECTION   143 ( 3 )   522 - 528   2015.2

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  • Effectiveness of Trivalent Influenza Vaccine among Children in Two Consecutive Seasons in a Community in Japan Reviewed

    Tsubasa Suzuki, Yasuhiko Ono, Hidenori Maeda, Yoshiki Tsujimoto, Yugo Shobugawa, Clyde Dapat, Mohd Rohaizat Hassan, Chihiro Yokota, Hiroki Kondo, Isolde C. Dapat, Kousuke Saito, Reiko Saito

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   232 ( 2 )   97 - 104   2014.2

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  • Effectiveness of trivalent influenza vaccine among children in two consecutive seasons in a community in Japan. Reviewed

    Tsubasa Suzuki, Yasuhiko Ono, Hidenori Maeda, Yoshiki Tsujimoto, Yugo Shobugawa, Clyde Dapat, Mohd Rohaizat Hassan, Chihiro Yokota, Hiroki Kondo, Isolde C Dapat, Kousuke Saito, Reiko Saito

    The Tohoku journal of experimental medicine   232 ( 2 )   97 - 104   2014.2

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    Influenza vaccination is considered the single most important medical intervention for the prevention of influenza. The dose of trivalent influenza vaccine in children was increased almost double since 2011/12 season in Japan. We estimated the influenza vaccine effectiveness for children 1-11 years of age using rapid test kits in Isahaya City, involving 28,884 children-years, over two consecutive influenza seasons (2011/12 and 2012/13). Children were divided into two groups, vaccinated and unvaccinated, according to their vaccination record, which was obtained from an influenza registration program organized by the Isahaya Medical Association for all pediatric facilities in the city. There were 14,562 and 14,282 children aged from 1-11 years in the city in 2011 and 2012 respectively. In the 2011/12 season, the overall vaccine effectiveness in children from 1-11 years of age, against influenza A and B were 23% [95% confidence interval (CI): 14%-31%] and 20% [95% CI: 8%-31%], respectively. In the 2012/13 season, vaccine effectiveness against influenza A and B was 13% (95% CI: 4%-20%) and 9% (95% CI: -4%-21%), respectively. The vaccine effectiveness was estimated using the rapid diagnosis test kits. Age-stratified estimation showed that vaccine effectiveness was superior in younger children over both seasons and for both virus types. In conclusion, the trivalent influenza vaccine has a significant protective effect for children 1-11 years of age against influenza A and B infection in the 2011/12 season and against influenza A infection in the 2012/13 season in a community in Japan.

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  • Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan. Reviewed International journal

    Clyde Dapat, Hiroki Kondo, Isolde C Dapat, Tatiana Baranovich, Yasushi Suzuki, Yugo Shobugawa, Kousuke Saito, Reiko Saito, Hiroshi Suzuki

    Antiviral research   99 ( 3 )   261 - 9   2013.9

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    Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in Japan to the four NAIs using the fluorescence-based 50% inhibitory concentration (IC₅₀) method. Outliers were identified using box-and-whisker plot analysis and full NA gene sequencing was performed to determine the mutations that are associated with reduction of susceptibility to NAIs. A total of 117 influenza A(H1N1)pdm09, 59 A(H3N2), and 18 type B viruses were tested before NAI treatment and eight A(H1N1)pdm09 and 1 type B viruses were examined from patients after NAI treatment in the two seasons. NA inhibition assay showed type A influenza viruses were more susceptible to NAIs than type B viruses. The peramivir and laninamivir IC₅₀ values of both type A and B viruses were significantly lower than the oseltamivir and zanamivir IC₅₀ values. Among influenza A(H1N1)pdm09 viruses, the prevalence of H274Y viruses increased from 0% in the 2009-2010 season to 3% in the 2010-2011 season. These H274Y viruses were resistant to oseltamivir and peramivir with 200-300 fold increase in IC₅₀ values but remained sensitive to zanamivir and laninamivir. Other mutations in NA, such as I222T and M241I were identified among the outliers. Among influenza A(H3N2) viruses, two outliers were identified with D151G and T148I mutations, which exhibited a reduction in susceptibility to oseltamivir and zanamivir, respectively. Among type B viruses, no outliers were identified to the four NAIs. For paired samples that were collected before and after drug treatment, three (3/11; 27.3%) H274Y viruses were identified among A(H1N1)pdm09 viruses after oseltamivir treatment but no outliers were found in the laninamivir-treatment group (n=3). Despite widespread use of NAIs in Japan, the prevalence of NAI-resistant influenza viruses is still low.

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  • Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan Reviewed

    Clyde Dapat, Hiroki Kondo, Isolde C. Dapat, Tatiana Baranovich, Yasushi Suzuki, Yugo Shobugawa, Kousuke Saito, Reiko Saito, Hiroshi Suzuki

    ANTIVIRAL RESEARCH   99 ( 3 )   261 - 269   2013.9

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  • The South to North Variation of Norovirus Epidemics from 2006-07 to 2008-09 in Japan Reviewed International journal

    Shinako Inaida, Yugo Shobugawa, Shigeo Matsuno, Reiko Saito, Hiroshi Suzuki

    PLOS ONE   8 ( 8 )   e71696   2013.8

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  • Clinical effectiveness of neuraminidase inhibitors--oseltamivir, zanamivir, laninamivir, and peramivir--for treatment of influenza A(H3N2) and A(H1N1)pdm09 infection: an observational study in the 2010-2011 influenza season in Japan. Reviewed International journal

    Yugo Shobugawa, Reiko Saito, Isamu Sato, Takashi Kawashima, Clyde Dapat, Isolde Caperig Dapat, Hiroki Kondo, Yasushi Suzuki, Kousuke Saito, Hiroshi Suzuki

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   18 ( 6 )   858 - 64   2012.12

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    The clinical effectiveness of the newly released neuraminidase inhibitors (NAIs) laninamivir and peramivir has not been sufficiently evaluated in influenza-infected patients in clinical and practical settings. In this study, we analyzed the clinical data of 211 patients infected with influenza A virus subtype H3N2 (A(H3N2)) and 45 patients infected with influenza A virus subtype H1N1pdm (A(H1N1)pdm09) who received the NAIs oseltamivir, zanamivir, laninamivir, or peramivir during the 2010-2011 influenza season. The duration of fever from the first dose of the NAI to fever alleviation to <37.5 °C was evaluated as an indicator of the clinical effectiveness of the NAIs in the influenza-infected patients. For the A(H3N2)-infected patients, Kaplan-Meier analysis showed the peramivir treatment group had the fastest time of fever alleviation to <37.5 °C (median 17.0 h, 95 % confidence interval [CI] 7.2-26.8 h) of the four treatment groups. No significant difference was found in the time to fever alleviation among the other antivirals, oseltamivir, zanamivir, and laninamivir. Results of multivariate analysis, using a Cox proportional-hazards model (hazard ratio 3.321) adjusted for the factors age, sex, body weight, vaccination status, time from onset to the clinic visit, and body temperature showed significantly faster fever alleviation in the peramivir treatment group compared with the oseltamivir treatment group. For the A(H1N1)pdm09-infected patients, only the oseltamivir and zanamivir treatment groups were compared, and no significant difference in time to alleviation of fever was observed between the two groups. Based on a cycling probe real-time polymerase chain reaction (PCR) assay, none of the A(H1N1)pdm09 strains in this study had the H275Y mutation conferring oseltamivir resistance. Further evaluation of the clinical effectiveness of the newly released NAIs for influenza-infected patients, including those infected with A(H1N1)pdm09, is needed.

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  • Clinical effectiveness of neuraminidase inhibitors - Oseltamivir, zanamivir, laninamivir, and peramivir - For treatment of influenza A(H3N2) and A(H1N1)pdm09 infection: An observational study in the 2010-2011 influenza season in Japan Reviewed

    Yugo Shobugawa, Reiko Saito, Isamu Sato, Takashi Kawashima, Clyde Dapat, Isolde Caperig Dapat, Hiroki Kondo, Yasushi Suzuki, Kousuke Saito, Hiroshi Suzuki

    Journal of Infection and Chemotherapy   18 ( 6 )   858 - 864   2012.12

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  • Novel measurement of spreading pattern of influenza epidemic by using weighted standard distance method: retrospective spatial statistical study of influenza, Japan, 1999-2009 Reviewed

    Yugo Shobugawa, Seth A. Wiafe, Reiko Saito, Tsubasa Suzuki, Shinako Inaida, Kiyosu Taniguchi, Hiroshi Suzuki

    International Journal of Health Geographics   11 ( 1 )   20   2012.6

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  • Novel measurement of spreading pattern of influenza epidemic by using weighted standard distance method: retrospective spatial statistical study of influenza, Japan, 1999-2009. Reviewed International journal

    Yugo Shobugawa, Seth A Wiafe, Reiko Saito, Tsubasa Suzuki, Shinako Inaida, Kiyosu Taniguchi, Hiroshi Suzuki

    International journal of health geographics   11   20 - 20   2012.6

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  • Genetic Characterization of Human Influenza Viruses in the Pandemic (2009-2010) and Post-Pandemic (2010-2011) Periods in Japan Reviewed International journal

    Isolde C. Dapat, Clyde Dapat, Tatiana Baranovich, Yasushi Suzuki, Hiroki Kondo, Yugo Shobugawa, Reiko Saito, Hiroshi Suzuki

    PLOS ONE   7 ( 6 )   e36455   2012.6

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  • A Map for the Future: Measuring Radiation Levels in Fukushima, Japan. Reviewed

    Yoh Kawano, David Lawrence Shepard, Yugo Shobugawa, Jun Goto, Tsubasa Suzuki, Yoshihiro Amaya, Masayasu Oie, Takuji Izumikawa, Hidenori Yoshida, Yoshinori Katsuragi, Toshihiro Takahashi, Shigeru Hirayama, Reiko Saito, Makoto Naito

    2012 IEEE Global Humanitarian Technology Conference   53 - 58   2012

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  • High Frequency of Repeated Infections Due to Emerging Genotypes of Human Respiratory Syncytial Viruses among Children during Eight Successive Epidemic Seasons in Japan Reviewed International journal

    Masahiro Yamaguchi, Yasuko Sano, Isolde C. Dapat, Reiko Saito, Yasushi Suzuki, Akihiko Kumaki, Yugo Shobugawa, Clyde Dapat, Makoto Uchiyama, Hiroshi Suzuki

    JOURNAL OF CLINICAL MICROBIOLOGY   49 ( 3 )   1034 - 1040   2011.3

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  • Geodemographics profiling of influenza A and B virus infections in community neighborhoods in Japan Reviewed International journal

    Yoshinari Kimura, Reiko Saito, Yoshiki Tsujimoto, Yasuhiko Ono, Tomoki Nakaya, Yugo Shobugawa, Asami Sasaki, Taeko Oguma, Hiroshi Suzuki

    BMC Infectious Diseases   11 ( 1 )   36 - 36   2011.2

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  • New Genotypes within Respiratory Syncytial Virus Group B Genotype BA in Niigata, Japan Reviewed International journal

    Isolde C. Dapat, Yugo Shobugawa, Yasuko Sano, Reiko Saito, Asami Sasaki, Yasushi Suzuki, Akihiko Kumaki, Hassan Zaraket, Clyde Dapat, Taeko Oguma, Masahiro Yamaguchi, Hiroshi Suzuki

    JOURNAL OF CLINICAL MICROBIOLOGY   48 ( 9 )   3423 - 3427   2010.9

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    DOI: 10.1128/JCM.00646-10

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  • Emerging genotypes of human respiratory syncytial virus subgroup A among patients in Japan Reviewed International journal

    Yugo Shobugawa, Reiko Saito, Yasuko Sano, Hassan Zaraket, Yasushi Suzuki, Akihiko Kumaki, Isolde Dapat, Taeko Oguma, Masahiro Yamaguchi, Hiroshi Suzuki

    Journal of Clinical Microbiology   47 ( 8 )   2475 - 2482   2009.8

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    DOI: 10.1128/JCM.00115-09

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  • Recurrence and persistence of fever in children who developed amantadine-resistant influenza viruses after treatment Reviewed

    Yugo Shobugawa, Reiko Saito, Isamu Sato, Danjuan Li, Yasushi Suzuki, Asami' Sasaki, Maki Sato, Hiroshi Suzuki

    Tohoku Journal of Experimental Medicine   214 ( 2 )   129 - 138   2008.2

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    DOI: 10.1620/tjem.214.129

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  • Genetic analysis of influenza A/H3N2 and A/H1N1 viruses circulating in Vietnam from 2001 to 2006 Reviewed International journal

    Danjuan Li, Reiko Saito, Mai T. Q. Le, Hang L. K. Nguyen, Yasushi Suzuki, Yugo Shobugawa, Duc T. Dinh, Phuong V. M. Hoang, Huong T. T. Tran, Ha K. Nghiem, Long T. Hoang, Lien P. Huynh, Hien T. Nguyen, Makoto Nishikawa, Hiroshi Suzuki

    JOURNAL OF CLINICAL MICROBIOLOGY   46 ( 2 )   399 - 405   2008.2

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    DOI: 10.1128/JCM.01549-07

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  • Effectiveness of oseltamivir treatment among children with influenza A or B virus infections during four successive winters in Niigata city, Japan Reviewed

    Maki Sato, Reiko Saito, Isamu Sato, Naohito Tanabe, Yugo Shobugawa, Asami Sasaki, Danjuan Li, Yasushi Suzuki, Mizuho Sato, Takatsugu Sakai, Taeko Oguma, Hiroki Tsukada, Fumitake Gejyo, Hiroshi Suzuki

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   214 ( 2 )   113 - 120   2008.2

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    DOI: 10.1620/tjem.214.113

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  • Increased incidence of adamantane-resistant influenza A(H1N1) and A(H3N2) viruses during the 2006-2007 influenza season in Japan Reviewed International journal

    Reiko Saito, Yasushi Suzuki, Danjuan Li, Hassan Zaraket, Isamu Sato, Hironori Masaki, Takashi Kawashima, Shigeyoshi Hibi, Yasuko Sano, Yugo Shobugawa, Taeko Oguma, Hiroshi Suzuki

    JOURNAL OF INFECTIOUS DISEASES   197 ( 4 )   630 - 632   2008.2

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  • High prevalence of amantadine-resistance influenza A (H3N2) in six prefectures, Japan, in the 2005-2006 season Reviewed International journal

    Reiko Saito, Danjuan Li, Yasushi Suzuki, Isamu Sato, Hironori Masaki, Hidekazu Nishimura, Takashi Kawashima, Yutaka Shirahige, Chieko Shimomura, Norichika Asoh, Satoshi Degawa, Hidefumi Ishikawa, Maki Sato, Yugo Shobugawa, Hiroshi Suzuki

    JOURNAL OF MEDICAL VIROLOGY   79 ( 10 )   1569 - 1576   2007.10

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    DOI: 10.1002/jmv.20946

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  • Measles outbreaks in high schools closely associated with sporting events in Niigata, Japan Reviewed International journal

    Asami Sasaki, Hiroshi Suzuki, Takatugu Sakai, Maki Sato, Yugo Shobugawa, Reiko Saito

    JOURNAL OF INFECTION   55 ( 2 )   179 - 183   2007.8

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    DOI: 10.1016/j.jinf.2007.04.004

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  • Epidemiology of influenza in Hanoi, Vietnam, from 2001 to 2003 Reviewed International journal

    Hang L. K. Nguyen, Reiko Saito, Ha K. Ngiem, Makoto Nishikawa, Yugo Shobugawa, Doan C. Nguyen, Long T. Hoang, Lien P. Huynh, Hiroshi Suzuki

    JOURNAL OF INFECTION   55 ( 1 )   58 - 63   2007.7

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    DOI: 10.1016/j.jinf.2006.12.001

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  • Molecular epidemiology of respiratory syncytial virus infections among children with acute respiratory symptoms in a community over three seasons. Reviewed International journal

    Mizuho Sato, Reiko Saito, Takatsugu Sakai, Yasuko Sano, Makoto Nishikawa, Asami Sasaki, Yugo Shobugawa, Fumitake Gejyo, Hiroshi Suzuki

    Journal of clinical microbiology   43 ( 1 )   36 - 40   2005.1

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    DOI: 10.1128/JCM.43.1.36-40.2005

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Books

  • 地域包括ケアの推進に向けたまちづくり支援ガイド

    菖蒲川 由郷( Role: Joint author)

    2019.3 

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  • 社会疫学

    菖蒲川 由郷( Role: Joint translator)

    2017.9 

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  • 介護予防活動のための地域診断データの活用と組織連携ガイド~地域包括ケアの推進に向けて

    菖蒲川 由郷( Role: Joint author)

    2017.6 

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  • ソーシャル・キャピタルと健康政策~地域で活用するために

    菖蒲川 由郷( Role: Joint translator)

    2013.8 

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  • 南相馬市空間線量率地図(2012年~2017年)【第1版~第5版】

    菖蒲川 由郷( Role: Joint author)

    2012 

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MISC

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Presentations

  • RSウィルスの夏の流行条件と抗RS剤について

    菖蒲川 由郷

    石川県バリビズマブ適正使用を考える会  2019.5 

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  • RSウィルスの流行変化について

    菖蒲川 由郷

    北海道RSウィルス研究会  2018.10 

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  • RSウィルス、夏の流行が起きる気象条件~7シーズンの疫学解析より~

    菖蒲川 由郷

    第59回日本臨床ウィルス学会ランチョンセミナー  2018.6 

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  • RSウィルス、夏の流行が起きる気象条件~7シーズンの疫学解析より~

    菖蒲川 由郷

    シナジスインターネットライブセミナー  2018.5 

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  • RS ウイルス、夏の流行が起きる気象条件~ 7シーズンの疫学解析より~

    菖蒲川 由郷

    第49回日本小児感染症学会ランチョンセミナー  2018 

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Works

  • Bago HEART

    菖蒲川 由郷

    2019.3

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  • Yangon HEART

    菖蒲川 由郷

    2019.3

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  • Aga HEART

    菖蒲川 由郷

    2018.12

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  • Niigata HEART

    菖蒲川 由郷

    2014.10

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Research Projects

  • 美しい場所は健康をもたらすか?環境美の包括的理解と脳領域の解明

    Grant number:22K10578

    2022.4 - 2025.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    谷 友香子, 菖蒲川 由郷

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • How do older adults feel happy though they have disease or disability? The longitudinal study in Japan and South East Asia.

    Grant number:21K18453

    2021.7 - 2024.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

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  • 高齢者の食の多様性を確保するための人のつながりと地理的要因の検討~二国間比較研究

    Grant number:21K02131

    2021.4 - 2024.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    太田 亜里美, 菖蒲川 由郷, 村山 伸子

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    Grant amount:\3380000 ( Direct Cost: \2600000 、 Indirect Cost:\780000 )

    日本とインドネシアにおける高齢者の食の多様性に関わる様々な個人・環境要因である『食へのアクセス』を把握し、両国の介護予防対策につ なげることが目的である。インドネシアの大学教授らとインドネシアの60歳以上の高齢者の食、生活習慣に関わる調査協力を依頼し、結果から 簡易に食評価のできる『インドネシア多様性評価スコア』の作成を行う。日本とインドネシアの高齢者の二国間比較により、お互いの国の『食 へのアクセス』の利点、問題点を客観的に評価することができ、各国の新たな食を通した介護予防対策ができると考える。本研究はインドネシアの60歳以上の高齢者300人をボゴール市の代表的な3地区から無作為抽出する予定である。将来的にインドネシアの主要な都市数か所で高齢者調査を行う予定であり、本研究の質問項目は日本や他のアジア諸国で行った質問項目(社会経済状況、生活習慣な ど、友人関係など)に加え、訪問による対面インタビュー、体重、身体測定、握力、血圧測定も検討している。食の評価がだれもが簡易にできるよう『インドネシア 高齢者食の多様性評価スコア』の作成を行う。日本においてはN市と2016年、2019年に郵送による高齢者大規模調査を行い5000人の追跡ができている。食の多様性に関わる質問も含まれて おり、2022年にも同対象者の追跡調査を行う予定である。日本の『食へのアクセス』の客観的な評価が行える事で、新たな視点から、高齢者の健康な食の確保につながる地域づくり政策を提案できると考える。

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  • ミャンマー農村部における高血圧の予防・診断・治療の段階的介入パッケージの実装研究

    2018.8 - 2019.3

    Awarding organization:AMED

    菖蒲川 由郷

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  • Estimation of future needs of life support services among community-dwelling older adults

    Grant number:18H03107

    2018.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

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  • Detailed pattern of physical activity/sedentary behavior and cognitive decline among older adults: a cohort study

    Grant number:18K10829

    2018.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Kikuchi Hiroyuki

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    This study is a longitudinal study to investigate the longitudinal association between objectively-measured physical activity and cognitive function among 537 older adults living in Tokamachi City, Niigata Prefecture. Within the period of this study, the following findings were published in an international journal: (1) moderate-to-vigorous physical activity (MVPA) is related to cognitive function, (2) MVPA time is related to hippocampal volume, and (3) frailty in the elderly is related to duration of sedentary activity lasting 30 minutes or longer. On the other hand, the longitudinal analysis was not completed because the follow-up survey was delayed due to COVID-19. We plan to conduct these analyses as soon as the longitudinal data are fixed.

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  • Why epidemic period of respiraotry syncytial virus has shift to summer time?

    Grant number:18K10043

    2018.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Saito Reiko

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    We examined the causes of the RSV epidemic that changed significantly from winter to summer nationwide in Japan from 2017. Epidemiological analysis strongly suggested that the significant increase in the number of overseas travelers in Japan in recent years may have caused a change of the season in the the RSV epidemic. We also conducted sample collection survey with the cooperation of clinicians from Hokkaido to Okinawa. A total of 973 samples were collected, 193 type A and 290 type B RSV. In 2018 and 2019, RSV was prevalent in Okinawa one or two months ahead of the rest of the country, and genetic analysis suggested that the Okinawan virus may have spread nationwide subsequently. In 2020, RSV was detected only in Okinawa from October to November, which was considered to be the effect of corona virus control measurements.

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  • 身体活動・座位行動パターンと認知機能低下に関するコホート研究

    2018.4 - 2020.3

    System name:基盤研究(C)

    Awarding organization:文科省

    菊池 宏幸

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  • 地域在住高齢者が持つ生活支援ニーズ量の将来推計方法の確立

    2018.4 - 2020.3

    System name:基盤研究(B)

    Awarding organization:文科省

    村山 洋史

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  • RSウイルスはなぜ夏に流行るようになったか?温暖化とウイルス変異の多角的解析

    2018.4 - 2020.3

    System name:基盤研究(C)

    Awarding organization:文科省

    齋藤 玲子

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  • (AMED)ミャンマーとマレーシアにおける高齢者社会疫学調査と地域アセスメントツールの開発

    2017.4 - 2019.3

    Awarding organization:AMED

    菖蒲川 由郷

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  • 地域包括ケア推進に向けた地域診断ツールの活用による地域マネジメント支援に関する研究

    2017.4 - 2018.3

    Awarding organization:長寿科学研究開発事業(一次公募)

    近藤 尚己

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  • lucidation of environmental factors that influence food intake and exercise of elderly people using a geographical information system.

    Grant number:16K00913

    2016.4 - 2020.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Ota Asami

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    We conducted a survey of 10,000 elderly people in N city. BMI <20 and weight loss was defined as malnutrition as subjective health was significantly poor. Low food diversity score, not meeting friends, not driving and short walking time were the risk factors of malnutrition. No association was found in sports or gardening. Environmental factors such as the number of grocery stores and the number of local teas, and population density were not but low aging rate of the district related to malnutrition. In addition, low levels of "trust in the community" at the individual level was associated with poor nutrition, but no association was found at the regional level by multilevel analysis. The relationship between social capital and malnutrition cannot be denied, and needs further investigation.

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  • Radioactive cesium deposition mapping and development of a high position resolution mapping system

    Grant number:16K00543

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Goto Jun, SHOBUGAWA Yugo, TAKAHASHI Toshihiro, AMAYA Yoshihiro, YOSHIDA Hidenori, TAKAHASHI Takeshi, IZUMIKAWA Takuji

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    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    In this study, we performed car-borne survey using ASURA which is a directional car-borne survey system. Distribution of radioactive cesium deposition were measured on Route 6, Joban Expressway, etc.
    We also developed a on-foot survey system to measure radioactive cesium deposition in places which are difficult to measure by car-borne survey such as forests.

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  • Analysis of evolution and transmission route of influenza B viruses after introduction of novel quadrivalent influenza vaccine

    Grant number:16K19269

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category:Grant-in-Aid for Young Scientists (B)

    Awarding organization:Japan Society for the Promotion of Science

    ODAGIRI TAKASHI, Saito Reiko, Shobugawa Yugo

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    From 2015/2016 season, the novel influenza vaccine was introduced in Japan. In this study project, we analyzed the epidemiology and evolutionary pattern of influenza B viruses after novel influenza vaccine introduction. We revealed Victoria and Yamagata lineages were co-circulated during study period. However the ratio of Victoria and Yamagata lineages were different in each season. Although, some strains which had isolated in our study had the amino acid mutations, we could not identify the mutation which associated with antigenic change. And we found the substitution rate was not so much different among pre- and post-introduction of novel influenza vaccine. Further study would unveil the factors which associate with large scale epidemics of influenza B viruses.

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  • 地理情報システムによる高齢者の食品摂取・運動頻度に影響する地域環境要因の解明

    2016.4 - 2018.3

    System name:基盤研究(C)

    Awarding organization:文科省

    太田 亜里美

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  • 介護予防を推進する地域づくりを戦略的に進めるための研究

    2016.4 - 2018.3

    System name:介護予防を推進する地域づくりを戦略的に進めるための研究(28110101)

    近藤 克則

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    Grant type:Competitive

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  • 農村活性化事業が農村高齢者の健康維持と地域の健康と豊かなソーシャルキャピタルの醸成につな がることを実証する研究

    2016.4 - 2018.3

    Awarding organization:農林水産省

    菖蒲川 由郷

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    Authorship:Principal investigator  Grant type:Competitive

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  • ミャンマーにおける呼吸器感染症制御へのアプローチ

    2015.4 - 2019.3

    System name:感染症研究国際展開戦略プログラム

    齋藤 玲子

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    Grant type:Competitive

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  • Natural disaster support and public health nurse activities by regional diagnosis using spatial analysis in super aged and mountainous rural area

    Grant number:15K15929

    2015.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    TSUBOKAWA, Tomoko, SHOUBUGAWA Yugo

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    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

    In cooperation with Aga Town, which is a super-aged and mountainous area, we developed a visualization system for spatial diagnosis using geographical information in order to support vulnerable people. We included population density, snowfall, health survey results of older people, data of illness and so on. This system can present disaster prevention and health problems for each area. Integration of disaster risk area and evacuation site information to clarify the focus on evacuation support areas, and analysis of the potential needs of the older people's bus use can be used for future disaster recovery activities. An analysis of the relationship between community social capital and participation in health activities shows suggestions for building a system from peacetime. In the future, we will share this system with the residents in the district activity of public health nurses and use it for evacuation support at the time of disaster participation.

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  • Comparison of social determinants of health between urban and rural using GIS (geographic information system) and questionnaire survey

    Grant number:26460828

    2014.4 - 2017.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Shobugawa Yugo

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    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    To compare the social determinants of health between urban and rural, we have done social epidemiological survey in three municipalities in Niigata prefecture including urban and rural. Among various health indicators, we took two parameters: 1) underweight defined BMI<18.5; 2) depressive status defined GDS(geriatric depression scale)=10 or greater. Underweight was significantly associated with high age, sex, poor health status, and lower socio-economic status. In addition, poor communication with neighbor was significant factor with underweight only in rural. Depressive status was strongly associated with having no hobby in rural and poor neighborhood communication in urban.
    We found certain difference of social determinants of health between urban and rural through the research.

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  • 地理情報システムと住民アンケートによる都市vs農村の健康の社会的決定要因の解明

    2014.4 - 2016.3

    System name:基盤研究(C)

    Awarding organization:文科省

    菖蒲川 由郷

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  • Influenza virus transmission, evolution and appearance of drug resistant viruses in Asia.

    Grant number:25305014

    2013.4 - 2016.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    SAITO Reiko, SAITOH Akihiko, FUJII Masahiro, SHOBUGAWA Yugo, HASEGAWA Go, SAITO Kosuke, HIBINO Akinobu, KONDO Hiroki, ODAGIRI Takashi, SUZUKI Hiroshi, TAMURA Tsutomu, Dapat Clyde, Yadanar Kyaw, Yi Yi Myint, Nay Lin, Htay Htay Tin, Khin Yi OO, Latt Latt Kyaw, Rohaizat Mohd Hassan, Shamsul Azhar Shah, Nguyen Le Khanh Hang, Nguyen Phuong Anh, Le Quynh Mai, Zaraket Hassan, Dbaibo Ghassan

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    Grant amount:\17680000 ( Direct Cost: \13600000 、 Indirect Cost:\4080000 )

    During the fiscal three years from 2013 to 2015, we conducted influenza virus surveillance in four countries, that is, Myanmar, Malaysia, Vietnam, and Lebanon. We collected 1820 nasopharyngeal samples from influenza-like illness patients and isolated 456 influenza virus (136 of A/H1N1pdo09, 169 of A/H3N2, and 151 of B). We estimated transmission patterns, and it turned out A/H1N1pdm09 shuttles between Asian side (Myanmar and Japan) and Europe side (Lebanon). In contrast, a new genotype in A/H3N2 appears in Myanmar a half year earlier than in Japan and Lebanon, that suggested A/H3N2 had one way transmission direction from Myanmar to Japan or to Lebanon. Type B did not show a certain geographical tendency due to fewer genetic diversity within Yamagata or Victoria lineages. We analyzed appearance of drug resistant influenza virus by the genetic marker assay for NA-H275Y and drug susceptibility test, but there was no appearance of resistant strains against neuraminidase inhibitors.

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  • アジアを中心としたインフルエンザウイルスのグローバルな進化と薬剤耐性株の伝播追跡

    2013.4 - 2015.3

    System name:基盤研究(B)

    Awarding organization:文科省

    齋藤玲子

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    Grant type:Competitive

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  • MeasurementofradiationlevelanddistributionofchildrenbyelementaryschooldistrictsinMinamisomacityusinggeographicinformationsyste

    2012.4 - 2014.3

    Yugo Shobugawa

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    Authorship:Principal investigator  Grant type:Competitive

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  • Measurement of radiation level and distribution of children by elementary school districts in Minamisoma city using geographic information system

    Grant number:24790613

    2012.4 - 2014.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category:Grant-in-Aid for Young Scientists (B)

    Awarding organization:Japan Society for the Promotion of Science

    SHOBUGAWA Yugo

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    We measured radiation levels in Minamisoma city by using a vehicle-installed dosimeter system combined with GPS. With the aid of geographic information systems (GIS), we made maps of radiation level in Minamisoma city, using the measured radiation level data. The maps were distributed to citizen in Minamisoma by uploading on city website and printing map books. Also, web-based map was developed by UCLA collaborative researchers, and was open to public. From the measured data, average radiation levels of circumstance within 500m from each elementary school were all under 0.4 micro Sv/h. Inside of the school field after decontamination efforts, radiation levels might be lower than 0.4 micro Sv/h. We also conducted questionnaire survey to guardians of school children in Minamisoma, and found guardians live closer to Fukushima nuclear power plant have much anxiety to grow their child. It is still important to provide exact information of the radiation level for their safety and relief.

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Teaching Experience (researchmap)

  • 国際保健

    Institution name:新潟大学、東京医科歯科大学

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  • 国際保健

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  • GIS

    Institution name:新潟大学、東北大学

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