2023/12/12 更新

写真a

ヌマノ フジト
沼野 藤人
NUMANO Fujito
所属
医歯学総合病院 小児科 講師
職名
講師
外部リンク

学位

  • 博士(医学) ( 2012年9月   新潟大学 )

経歴(researchmap)

  • 新潟大学   医歯学総合病院 小児科   助教

    2015年8月 - 現在

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  • 新潟大学   医歯学総合病院 小児科   特任助教

    2011年8月 - 2012年3月

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経歴

  • 新潟大学   医歯学総合病院 小児科   講師

    2023年12月 - 現在

  • 新潟大学   医歯学総合病院 小児科   助教

    2015年8月 - 2023年11月

  • 新潟大学   医歯学総合病院 小児科   特任助教

    2011年8月 - 2012年3月

 

論文

  • Pulmonary Artery Dilation and Right Ventricular Function in Acute Kawasaki Disease 査読

    Fujito Numano, Chisato Shimizu, Adriana H. Tremoulet, Dan Dyar, Jane C. Burns, Beth F. Printz

    PEDIATRIC CARDIOLOGY   37 ( 3 )   482 - 490   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Coronary artery inflammation and aneurysm formation are the most common complications of Kawasaki disease (KD). Valvulitis and myocarditis are also well described and may lead to valvar regurgitation and left ventricular dysfunction. However, functional changes in the right heart have rarely been reported. We noted several acute KD patients with dilated pulmonary arteries (PA) and thus sought to systematically characterize PA size and right-heart function in an unselected cohort of KD patients cared for at a single clinical center. Clinical, laboratory, and echocardiographic data from 143 acute KD subjects were analyzed. PA dilation was documented in 23 subjects (16.1 %); these subjects had higher median right ventricle myocardial performance index (RV MPI), higher ratio of early tricuspid inflow velocity to tricuspid annular early diastolic velocity (TV E/e'), and lower median TV e' velocity compared to the non-PA dilation group (0.50 vs 0.38 p < 0.01, 4.2 vs 3.6 p < 0.05, and 13.5 vs 15.2 cm/s p < 0.01, respectively). Almost all subjects with PA dilation had improved PA Z-score, RV MPI, and TV E/e' in the subacute phase (p < 0.01). There were no significant differences in indices of left ventricle function between PA dilation group and non-PA dilation group. In summary, PA dilation was documented in 16 % of acute KD subjects. These subjects were more likely to have echocardiographic indices consistent with isolated RV dysfunction that improved in the subacute phase. The long-term consequence of these findings will require longitudinal studies of this patient population.

    DOI: 10.1007/s00246-015-1303-5

    Web of Science

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  • Galectin-3 is a marker of myocardial and vascular fibrosis in Kawasaki disease patients with giant aneurysms 査読

    Fujito Numano, Chisato Shimizu, Susan Jimenez-Fernandez, Matthew Vejar, Toshiaki Oharaseki, Kei Takahashi, Andrea Salgado, Adriana H. Tremoulet, John B. Gordon, Jane C. Burns, Lori B. Daniels

    INTERNATIONAL JOURNAL OF CARDIOLOGY   201   429 - 437   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Backgrounds: Galectin-3 (Gal-3) is a multifunctional matricellular protein associated with heart failure and cardiovascular events. Gal-3 is required for transforming growth factor-beta pathway-mediated myofibroblast activation that is a key process in coronary artery aneurysm formation in Kawasaki Disease (KD). Autopsies from young adults late after KD onset (AKD) have demonstrated bridging fibrosis throughout the myocardium and arteries. In this study, we postulated that Gal-3 may participate in the pathogenesis of myocardial and vascular fibrosis and the remodeling of coronary artery aneurysms following acute KD.
    Methods and results: We measured plasma Gal-3 levels in 63 pediatric KD (PKD) and 81 AKD subjects. AKD subjects with giant aneurysms had significantly higher Gal-3 levels compared to the other adult groups (all p < 0.05). All PKD groups had significantly higher Gal-3 levels than pediatric healthy controls (HC) (all p < 0.05). Histological and immunohistochemical staining was performed on tissues from 10 KD autopsies and one explanted heart. Gal-3 positive staining was detected associated with acute inflammation and in spindle-shaped cells in the myocardium and arterial wall in KD subjects with giant aneurysms.
    Conclusions: AKD subjects with giant aneurysms and PKD subjects had significantly higher plasma Gal-3 levels than HC and Gal-3 expression was increased in the myocardium of KD subjects who died with either acute inflammation or marked myocardial fibrosis. Gal-3 may be a clinically useful biomarker that identifies a subset of KD patients at highest risk of myocardial and vascular fibrosis, and may be an attractive therapeutic target to prevent myocardial dysfunction in this subset. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ijcard.2015.07.063

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受賞

  • 11th China-Korea-Japan pediatric heart forum Young Investigate Award

    2015年10月   China-Korea-Japan pediatric heart forum   Galectin-3 is a marker of myocardial and vascular fibrosis in Kawasaki disease patients with giant aneurysms

    Fujito Numano, Chisato Shimizu, Susan Jimenez-Fernandez, Matthew Vejar, Toshiaki Oharaseki, Kei Takahashi, Andrea Salgado, Adriana H. Tremoulet, John B. Gordon, Jane C. Burns, Lori B. Daniels

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    受賞区分:国際学会・会議・シンポジウム等の賞  受賞国:中華人民共和国

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