Updated on 2026/07/26

写真a

 
SAITOH Kousuke
 
Organization
Academic Assembly Institute of Medicine and Dentistry - Assistant Professor
Faculty of Medicine School of Medicine Assistant Professor
Graduate School of Medical and Dental Sciences Community Disease Control Infectious Disease Control and International Medicine Assistant Professor
Organization for Research Administration Research Associate Professor
Title
Assistant Professor
External link

Degree

  • 博士(医学) ( 2000.3   東京医科歯科大学 )

Research Interests

  • 老々介護

  • frailty

  • Dementia

Research History (researchmap)

  • 新潟大学大学院医歯学総合研究科   研究准教授（新潟大学研究統括機構）

    2024.2

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Research History

  • Niigata University   Faculty of Medicine School of Medicine   Assistant Professor

    2011.10

  • Niigata University   Graduate School of Medical and Dental Sciences Community Disease Control Infectious Disease Control and International Medicine   Assistant Professor

    2011.10

 

Papers

  • Pneumococcal vaccination, but not influenza vaccination, is negatively associated with incident dementia among Japanese older adults: The JAGES 2013-2022 prospective cohort study. Reviewed International journal

    Kousuke Iwai-Saito, Koryu Sato, Masahiro Fujii, Katsunori Kondo

    Brain, Behavior, and Immunity   2024.6

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: It is unclear whether inactivated influenza vaccination (IIV) or pneumococcal vaccination are associated with the risk of dementia; however, both types of vaccination are recommended for older adults. Studies have shown that the IIV is negatively associated with incident dementia; however, the uptake of pneumococcal vaccinations has not been considered. We investigated the independent associations of IIV and 23-valent pneumococcal polysaccharide vaccine (PPSV23) with incident dementia in older adults. METHODS: Health-related information on older Japanese adults was obtained through a baseline survey conducted in 2013 (baseline survey). The uptake of IIV and PPSV23 was determined in a second survey conducted in 2016 (second wave). Both surveys were conducted among independent Japanese older adults aged ≥ 65 years at the two surveys and who had not been certified as needing long-term care (LTC). In the second wave, 9,865 participants were followed up for 3.5 years (short-term follow-up), and 6,995 participants were followed up for six years and five months (long-term follow-up) until they required LTC due to dementia onset (incident dementia). A competing risk model with stabilized inverse probability weighting (SIPW) was constructed to calculate the hazard ratios (HRs) and 95 % confidence intervals (CIs) of incident dementia. RESULTS: PPSV23 uptake was negatively associated with incident dementia among participants in both the short- and long-term follow-up periods after SIPW (short-term follow-up: HR: 0.77, 95 % CI: 0.63 - 0.95; long-term follow-up: HR: 0.83, 95 % CI: 0.70 - 0.97). Conversely, IIV uptake was not associated with incident dementia among participants in either follow-up group (short-term follow-up: HR: 0.86, 95 % CI: 0.63-1.16; long-term follow-up: HR: 0.99, 95 % CI: 0.76-1.29). The PPSV23 uptake was negatively associated with incident dementia in participants without the IIV uptake (short-term follow-up: HR: 0.44, 95 % CI: 0.24 - 0.81; long-term follow-up: HR: 0.47, 95 % CI: 0.29 - 0.76). Conversely, the IIV uptake was not associated with incident dementia regardless of the PPSV23 status (short-term follow-up: HR: 0.87, 95 % CI: 0.62 - 1.23; long-term follow-up: HR: 1.00, 95 % CI: 0.74 - 1.35). CONCLUSION: Our results suggest that the PPSV23 uptake was independently associated with the incidence of dementia. However, the IIV uptake was not associated with the incidence of dementia.

    File： 1-s2.0-S0889159124004604-main.pdf

    DOI： 10.1016/j.bbi.2024.06.020

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  • Association of frailty with influenza and hospitalization due to influenza among independent older adults: a longitudinal study of Japan Gerontological Evaluation Study (JAGES) Reviewed International journal

    Kousuke Iwai-Saito, Koryu Sato, Jun Aida, Katsunori Kondo

    BMC Geriatrics   23 ( 1 )   249 - 249   2023.4

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: It is unknown that whether frailty is a risk factor of influenza and the hospitalization among older adults, although it has been shown that frailty was associated with poor recovery from the hospitalization among those. We examined the association of frailty with influenza and the hospitalization and the effect by sex among independent older adults. METHODS: We used the longitudinal data from the Japan Gerontological Evaluation Study (JAGES), performed in 2016 and 2019 and conducted in 28 municipalities in Japan. The target population comprised 77,103 persons aged ≥ 65 years who did not need assistance from the public long-term care insurance. Primary outcome measures were influenza and hospitalization due to influenza. Frailty was evaluated with the Kihon check list. We estimated the risk of influenza, the hospitalization, those risks by sex, and the interaction for frailty and sex using Poisson regression adjusting for covariates. RESULTS: Frailty was associated with both influenza and the hospitalization among the older adults compared with nonfrail individuals after adjusting for covariates (influenza, frail: risk ratio {RR}: 1.36, 95% confidence interval {95% CI}: 1.20 - 1.53, and prefrail: RR: 1.16, 95% CI: 1.09 - 1.23; the hospitalization, frail: RR: 3.18, 95% CI: 1.84 - 5.57, and prefrail: RR: 2.13, 95% CI: 1.44 - 3.16). Male was associated with the hospitalization, but not associated with influenza compared to female (the hospitalization: RR: 1.70, 95% CI: 1.15 - 2.52 and influenza: RR: 1.01, 95% CI: 0.95 - 1.08). The interaction for frailty and sex was significant neither in influenza nor in the hospitalization. CONCLUSION: These results suggest that frailty is a risk of influenza and the hospitalization, that risks of the hospitalization are different by sex, but that the sex difference does not cause the effect heterogeneity of frailty on the susceptibility and severity among independent older adults.

    File： s12877-023-03979-y.pdf

    DOI： 10.1186/s12877-023-03979-y

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  • Associations of influenza and pneumococcal vaccinations with burdens of older family caregivers: The Japan Gerontological Evaluation study (JAGES) cross-sectional study. Reviewed

    Iwai-Saito K, Koryu Sato, Kondo K

    Vaccine   41 ( 2 )   444 - 451   2022.12

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    <h4>Background</h4>Influenza and pneumonia tend to be severe in older adults; thus, vaccination is necessary to prevent these illnesses. Vaccination is especially important for older family caregivers (OFCs) not only to prevent them from becoming ill, but also to prevent secondary infections in the family care receivers (FCRs), who are mostly frail older adults and have a higher risk of severe illness. Thus, we investigated whether caregiving burdens were associated with the vaccinations among older adults.<h4>Methods</h4>We used cross-sectional data from the Japan Gerontological Evaluation Study (JAGES), which was conducted in 64 Japanese municipalities from November 2019 to January 2020. The target population consisted of 26,177 individuals aged 65 years or older who were independent and did not need public long-term care. The primary outcome was the uptakes of either or both influenza and pneumococcal vaccinations. Multinomial logistic regressions were performed, setting those who underwent neither vaccinations as the reference group.<h4>Results</h4>Among the participants, 23.3 %, 25.8 %, 9.4 %, or 41.5 % underwent neither, only influenza, only pneumococcal, or the both vaccinations, respectively. The caregiving frequency, time length in a day, or dementia of FCR were negatively associated with influenza vaccination (caregiving almost every day: relative risk ratio {RRR}: 0.39, 95 % confident interval {95 % CI} [0.24-0.63]; caregiving almost all day: 0.44, 95 % CI: 0.23-0.85; caregiving for FCR: RRR:0.55, 95 % CI: 0.34-0.91). On the other hand, those caregiving burdens were not associated with pneumococcal only or the both vaccinations. Having a family physician mitigated all the negative effect of the caregiving burdens on the vaccinations.<h4>Conclusion</h4>Our results suggest that the caregiving burden is a barrier to influenza vaccination but not to pneumococcal vaccination and that having a physician mitigates the negative effect regardless of the burden kind.

    File： 1-s2.0-S0264410X22014608-main.pdf

    DOI： 10.1016/j.vaccine.2022.11.047

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  • Association of functional competencies with vaccination among older adults: a JAGES cross-sectional study Reviewed

    Kousuke Iwai-Saito, Koryu Sato, Katsunori Kondo

    Scientific Reports   12 ( 1 )   2022.10

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    It is unknown whether higher functions in sublevels of competence other than instrumental activities of daily living (IADL) are associated with vaccinations. This study examined whether higher functions, including intellectual activity (IA) and social role (SR), were associated with vaccinations among 26,177 older adults. Older adults with incapable activities in IA and SR had increased risks for non-receipt of influenza vaccinations (IA: for one incapable task/activity: incident rate ratio (IRR) = 1.05, 95% confidence interval (CI) = 1.02–1.09; SR: for two incapable tasks: IRR = 1.12, 95% CI = 1.08–1.16). Those with incapable activities in IADL and IA had increased risks for non-receipt of pneumococcal vaccination (IADL: for two incapable tasks: IRR = 1.13, 95% CI = 1.05–1.23; IA: for two incapable tasks: IRR = 1.10, 95% CI = 1.08–1.12). Those with incapable activities in IADL, IA, and SR had increased risks for non-receipt of both of the two vaccinations (IADL: for two incapable tasks: IRR = 1.17, 95% CI = 1.03–1.33; IA: for two incapable tasks: IRR = 1.18, 95% CI = 1.11–1.25; SR: for two incapable tasks: IRR = 1.13, 95% CI = 1.07–1.20). Having a family physician mitigated associations for non-receipt, regardless of competency. Our results suggest—maintaining the higher functions are important for older adults to undergo recommended vaccinations as scheduled; also, having a family physician to promote vaccinations is beneficial even for older adults with limited functions.

    File： s41598-022-22192-2.pdf

    DOI： 10.1038/s41598-022-22192-2

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    Other Link： https://www.nature.com/articles/s41598-022-22192-2

  • Social capital and pneumococcal vaccination (PPSV23) in community-dwelling older Japanese: a JAGES multilevel cross-sectional study. Reviewed International journal

    Kousuke Iwai-Saito, Yugo Shobugawa, Katsunori Kondo

    BMJ open   11 ( 6 )   e043723   2021.6

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: Inequalities exist between the 23-valent pneumococcal polysaccharide vaccination (PPSV23) rate in each municipality among Japanese older adults. Exploring individual-level and community-level intervenable factors is necessary to improve the vaccination rates. We examined the associations between community-level and individual-level social capital and the PPSV23 vaccination among older Japanese adults using multilevel Poisson regression analyses. DESIGN: Cross-sectional study. SETTING: We used data from the Japan Gerontological Evaluation Study, conducted between 3 October 2016 and 10 January 2017 in 631 districts, 39 municipalities and 18 prefectures. PARTICIPANTS: The target population comprised persons aged 65 years or older who are physically and cognitively independent (that is, not certified as needing long-term care). Further, 180 021 older adults from 39 Japanese municipalities were enrolled. PRIMARY OUTCOME MEASURE: The primary outcome was the PPSV23 vaccination among the Japanese older adults aged 65 years or older who did not have physical or cognitive disabilities. RESULTS: After adjusting for municipality-, community-, individual-levels effects with multiple imputation, 137 075 individuals who participated in one/more of the civic participation (participation of social groups), social cohesion (social tie), or reciprocity (mutual exchange of social support) were significantly associated with more vaccinations than those without the three social capitals among the 137 075 older adults (13.0% (95% CI 11.0% to 14.9%), 5.0% (95% CI 2.4% to 7.6%) or 33.9% (95% CI23.6% to 44.2%) increase, respectively, p>0.001 for all). The rich (≥+1 SD) community-level civic participation was significantly associated with 3.4% increase [95% CI 0.02% to 6.78%, p<0.05] of the PPSV23 vaccination among the older adults compared to those with the poor or standard one. CONCLUSIONS: Older adults with one/more of the three social capitals at the both levels received more PPSV23 vaccinations than those without those social capitals. Therefore, fostering of those social capitals may improve the inequality of the PPSV23 vaccination rate among older adults in each municipality.

    File： e043723.full.pdf

    DOI： 10.1136/bmjopen-2020-043723

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  • Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study). Reviewed International journal

    Kousuke Iwai-Saito, Yugo Shobugawa, Jun Aida, Katsunori Kondo

    Scientific reports   11 ( 1 )   7966 - 7966   2021.4

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    Pneumonia is a leading cause of mortality among older adults worldwide. Recently, several studies reported that frailty was associated with mortality among older adults hospitalized due to respiratory infectious diseases, including pneumonia. However, it is unknown whether frailty is associated with susceptibility to and severity of pneumonia in functionally-independent community-dwelling older adults. In this study, we examined whether frailty increased the susceptibility to pneumonia and hospitalization in older adults. We used cross-sectional data from the Japan Gerontological Evaluation Study; the data was collected by using mail-based, self-reported questionnaires from 177,991 functionally-independent community-dwelling older adults aged ≥ 65 years. Our results showed that frailty was significantly associated with both occurrence of and hospitalization due to pneumonia after adjustments with covariates; (Preference ratio {PR} 1.92, 95% confidence interval {95% CI} [1.66-2.22] and PR 1.80, 95% CI [1.42-2.28], respectively, p < 0.001 for the both). Pre-frailty was associated only with the occurrence of pneumonia. Besides, the instrumental activity of daily living, physical strength, nutrition status, oral function, homeboundness, and depression status in frail older adults were associated with either or both occurrence of and hospitalization due to pneumonia. Our results suggest that frailty influenced the susceptibility to and severity of pneumonia in older adults.

    File： s41598-021-86854-3.pdf

    DOI： 10.1038/s41598-021-86854-3

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  • Oral self-care, pneumococcal vaccination, and pneumonia among Japanese older people, assessed with machine learning. Reviewed International journal

    Yuko Inoue, Upul Cooray, Miho Ishimaru, Kousuke Saito, Kenji Takeuchi, Katsunori Kondo, Jun Aida

    The journals of gerontology. Series A, Biological sciences and medical sciences   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Pneumonia is a leading cause of death worldwide. It is a particularly serious burden in older people, as they tend to have a weakened immune response. Identifying the role of oral self-care and pneumococcal vaccination in healthy, independent older people can aid pneumonia prevention among them. This study investigated the associations between oral self-care, pneumococcal vaccination, and pneumonia experience among independent older people. METHODS: This cross-sectional study used data from the 2016 Japan Gerontological Evaluation Study (JAGES). We used machine learning to examine the association between oral self-care and the experience of pneumonia over the previous year, stratified by pneumococcal vaccination. The covariates were sex, age, years of education, equivalent annual income, medical history of stroke, oral health status (choking, dryness, number of teeth), and smoking status. The analysis included 17,217 independent older people aged 65 and over. RESULTS: The prevalence of pneumonia experienced among those who brushed their teeth once or less per day was 4.5% and 5.3% for those with and those without pneumococcal vaccinations, respectively. In the unvaccinated group, the odds ratio of pneumonia experience for those who brushed their teeth once or less a day was 1.57 (95% CI 1.15-2.14) compared to those who brushed their teeth three or more times a day. By contrast, there was no significant association between the frequency of toothbrushing and the experience of pneumonia among people who received pneumococcal vaccination. CONCLUSION: Oral care influenced the experience of pneumonia among independent older people who did not receive pneumococcal vaccination.

    File： glad161.pdf

    DOI： 10.1093/gerona/glad161

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  • Development of cycling probe based real-time PCR methodology for influenza A viruses possessing the PA/I38T amino acid substitution associated with reduced baloxavir susceptibility. Reviewed International journal

    Hidekazu Osada, Irina Chon, Wint Wint Phyu, Keita Wagatsuma, Nobuo Nagata, Takashi Kawashima, Isamu Sato, Tadashi Saito, Naoki Kodo, Hironori Masaki, Norichika Asoh, Yoshiko Tsuchihashi, Yutaka Shirahige, Yasuhiko Ono, Yasushi Shimada, Hirotsune Hamabata, Kousuke Saito, Reiko Saito

    Antiviral research   188   105036 - 105036   2021.4

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    Baloxavir marboxil has been used for influenza treatment since March 2018 in Japan. After baloxavir treatment, the most frequently detected substitution is Ile38Thr in polymerase acidic protein (PA/I38T), and this substitution reduces baloxavir susceptibility in influenza A viruses. To rapidly investigate the frequency of PA/I38T in influenza A (H1N1)pdm09 and A (H3N2) viruses in clinical samples, we established a rapid real-time system to detect single nucleotide polymorphisms in PA, using cycling probe real-time PCR. We designed two sets of probes that were labeled with either 6-carboxyfluorescein (FAM) or 6-carboxy-X-rhodamine (ROX) to identify PA/I38 (wild type strain) or PA/I38T, respectively. The established cycling probe real-time PCR system showed a dynamic linear range of 101 to 106 copies with high sensitivity in plasmid DNA controls. This real-time PCR system discriminated between PA/I38T and wild type viruses well. During the 2018/19 season, 377 influenza A-positive clinical samples were collected in Japan before antiviral treatment. Using our cycling probe real-time PCR system, we detected no (0/129, 0.0%) influenza A (H1N1)pdm09 viruses with PA/I38T substitutions and four A (H3N2) (4/229, 1.7%) with PA/I38T substitution prior to treatment. In addition, we found PA/I38T variant in siblings who did not received baloxavir treatment during an infection caused by A (H3N2) that afflicted the entire family. Although human-to-human transmission of PA/I38T variant may have occurred in a closed environment, the prevalence of this variant in influenza A viruses was still limited. Our cycling probe-PCR system is thus useful for antiviral surveillance of influenza A viruses possessing PA/I38T.

    DOI： 10.1016/j.antiviral.2021.105036

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  • Association of pneumococcal and influenza vaccination with patient-physician communication in older adults: A nationwide cross-sectional study from the JAGES 2016. Reviewed

    Koryu Sato, Naoki Kondo, Chiyoe Murata, Yugo Shobugawa, Kousuke Saito, Katsunori Kondo

    Journal of epidemiology   2021.2

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    BACKGROUND: Increasing the coverage of vaccinations recommended by the World Health Organization in the older adult population is an urgent issue, especially in the context of avoiding co-epidemics during the current coronavirus disease 2019 crisis. The aim of this study was to examine factors associated with the quality of perceived patient-physician communication and whether this variable was associated with increased odds of vaccination. METHODS: We used cross-sectional data from the Japan Gerontological Evaluation Study conducted from October 2016 to January 2017. The participants were 22,253 physically and cognitively independent individuals aged 65 or older living in 39 municipalities in Japan. Multilevel logit models were used to estimate the odds of vaccination. RESULTS: Among the participants, 40.0% and 58.8% had received pneumococcal and influenza vaccinations as per the recommended schedule, respectively. People with low educational levels were more likely to have a family physician but rate their experience in asking questions lower than those with higher educational levels. Having a family physician and high rating for physicians' listening attitude were positively associated with increased odds of pneumococcal and influenza vaccinations. High rating for patients' questioning attitude and shared decision-making, compared to an ambiguous attitude toward medical decision-making, were positively associated with increased odds of pneumococcal vaccination. CONCLUSION: The results suggest that promotion of having a family physician, better patient-physician communication, and shared decision-making may encourage older adults to undergo recommended vaccinations.

    DOI： 10.2188/jea.JE20200505

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  • MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia. Reviewed

    Kozakai T, Takahashi M, Higuchi M, Hara T, Saito K, Tanaka Y, Masuko M, Takizawa J, Sone H, Fujii M

    International journal of hematology   107 ( 3 )   337 - 344   2018.3

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  • USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells Reviewed

    Masaya Higuchi, Hiroki Kawamura, Hideaki Matsuki, Toshifumi Hara, Masahiko Takahashi, Suguru Saito, Kousuke Saito, Shuying Jiang, Makoto Naito, Hiroshi Kiyonari, Masahiro Fujii

    STEM CELL REPORTS   7 ( 6 )   1116 - 1129   2016.12

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    DOI： 10.1016/j.stemcr.2016.11.003

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  • The effects of neuraminidase inhibitors on the release of oseltamivir-sensitive and oseltamivir-resistant influenza viruses from primary cultures of human tracheal epithelium Reviewed

    Mutsuo Yamaya, Lusamba Nadine, Hiroshi Kubo, Kousuke Saito, Reiko Saito, Hidekazu Nishimura

    Journal of Medical Virology   87 ( 1 )   25 - 34   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：John Wiley and Sons Inc.  

    DOI： 10.1002/jmv.23974

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  • The effects of neuraminidase inhibitors on the release of oseltamivir-sensitive and oseltamivir-resistant influenza viruses from primary cultures of human tracheal epithelium. Reviewed

    Yamaya M, Nadine L, Kubo H, Saito K, Saito R, Nishimura H

    Journal of medical virology   87 ( 1 )   25 - 34   2015.1

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  • Characterization of human influenza viruses in lebanon during 2010-2011 and 2011-2012 post-pandemic seasons Reviewed

    Hassan Zaraket, Clyde Dapat, Soha Ghanem, Zainab Ali, Mireille Lteif, Hiroki Kondo, Isolde C. Dapat, Kousuke Saito, Ghazi Kayali, Hiroshi Suzuki, Ghassan Dbaibo, Reiko Saito

    Intervirology   57 ( 6 )   344 - 352   2014.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：S. Karger AG  

    DOI： 10.1159/000365758

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  • Effectiveness of trivalent influenza vaccine among children in two consecutive seasons in a community in Japan. Reviewed

    Tsubasa Suzuki, Yasuhiko Ono, Hidenori Maeda, Yoshiki Tsujimoto, Yugo Shobugawa, Clyde Dapat, Mohd Rohaizat Hassan, Chihiro Yokota, Hiroki Kondo, Isolde C Dapat, Kousuke Saito, Reiko Saito

    The Tohoku journal of experimental medicine   232 ( 2 )   97 - 104   2014.2

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    Influenza vaccination is considered the single most important medical intervention for the prevention of influenza. The dose of trivalent influenza vaccine in children was increased almost double since 2011/12 season in Japan. We estimated the influenza vaccine effectiveness for children 1-11 years of age using rapid test kits in Isahaya City, involving 28,884 children-years, over two consecutive influenza seasons (2011/12 and 2012/13). Children were divided into two groups, vaccinated and unvaccinated, according to their vaccination record, which was obtained from an influenza registration program organized by the Isahaya Medical Association for all pediatric facilities in the city. There were 14,562 and 14,282 children aged from 1-11 years in the city in 2011 and 2012 respectively. In the 2011/12 season, the overall vaccine effectiveness in children from 1-11 years of age, against influenza A and B were 23% [95% confidence interval (CI): 14%-31%] and 20% [95% CI: 8%-31%], respectively. In the 2012/13 season, vaccine effectiveness against influenza A and B was 13% (95% CI: 4%-20%) and 9% (95% CI: -4%-21%), respectively. The vaccine effectiveness was estimated using the rapid diagnosis test kits. Age-stratified estimation showed that vaccine effectiveness was superior in younger children over both seasons and for both virus types. In conclusion, the trivalent influenza vaccine has a significant protective effect for children 1-11 years of age against influenza A and B infection in the 2011/12 season and against influenza A infection in the 2012/13 season in a community in Japan.

    DOI： 10.1620/tjem.232.97

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  • Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan. Reviewed

    Dapat C, Kondo H, Dapat IC, Baranovich T, Suzuki Y, Shobugawa Y, Saito K, Saito R, Suzuki H

    Antiviral research   99 ( 3 )   261 - 269   2013.9

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  • Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan. Reviewed International journal

    Clyde Dapat, Hiroki Kondo, Isolde C Dapat, Tatiana Baranovich, Yasushi Suzuki, Yugo Shobugawa, Kousuke Saito, Reiko Saito, Hiroshi Suzuki

    Antiviral research   99 ( 3 )   261 - 9   2013.9

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    Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in Japan to the four NAIs using the fluorescence-based 50% inhibitory concentration (IC₅₀) method. Outliers were identified using box-and-whisker plot analysis and full NA gene sequencing was performed to determine the mutations that are associated with reduction of susceptibility to NAIs. A total of 117 influenza A(H1N1)pdm09, 59 A(H3N2), and 18 type B viruses were tested before NAI treatment and eight A(H1N1)pdm09 and 1 type B viruses were examined from patients after NAI treatment in the two seasons. NA inhibition assay showed type A influenza viruses were more susceptible to NAIs than type B viruses. The peramivir and laninamivir IC₅₀ values of both type A and B viruses were significantly lower than the oseltamivir and zanamivir IC₅₀ values. Among influenza A(H1N1)pdm09 viruses, the prevalence of H274Y viruses increased from 0% in the 2009-2010 season to 3% in the 2010-2011 season. These H274Y viruses were resistant to oseltamivir and peramivir with 200-300 fold increase in IC₅₀ values but remained sensitive to zanamivir and laninamivir. Other mutations in NA, such as I222T and M241I were identified among the outliers. Among influenza A(H3N2) viruses, two outliers were identified with D151G and T148I mutations, which exhibited a reduction in susceptibility to oseltamivir and zanamivir, respectively. Among type B viruses, no outliers were identified to the four NAIs. For paired samples that were collected before and after drug treatment, three (3/11; 27.3%) H274Y viruses were identified among A(H1N1)pdm09 viruses after oseltamivir treatment but no outliers were found in the laninamivir-treatment group (n=3). Despite widespread use of NAIs in Japan, the prevalence of NAI-resistant influenza viruses is still low.

    DOI： 10.1016/j.antiviral.2013.06.003

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  • Clinical effectiveness of neuraminidase inhibitors--oseltamivir, zanamivir, laninamivir, and peramivir--for treatment of influenza A(H3N2) and A(H1N1)pdm09 infection: an observational study in the 2010-2011 influenza season in Japan. Reviewed

    Shobugawa Y, Saito R, Sato I, Kawashima T, Dapat C, Dapat IC, Kondo H, Suzuki Y, Saito K, Suzuki H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   18 ( 6 )   858 - 864   2012.12

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  • Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells. Reviewed

    Kousuke Saito, Mineki Saito, Naoko Taniura, Takako Okuwa, Yoshiro Ohara

    Virology   403 ( 2 )   173-180   2010.8

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    DOI： 10.1016/j.virol.2010.04.018

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  • Hepatitis C Virus Core Protein Interacts With Fibrinogen-beta and Attenuates Cytokine Stimulated Acute-Phase Response Reviewed

    Malika Ait-Goughoulte, Arup Banerjee, Keith Meyer, Budhaditya Mazumdar, Kousuke Saito, Ratna B. Ray, Ranjit Ray

    HEPATOLOGY   51 ( 5 )   1505 - 1513   2010.5

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    DOI： 10.1002/hep.23502

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  • Analysis of the mechanism by which BALB/c mice having prior immunization with nucleocapsid protein of SARS-CoV develop severe pneumonia after SARS-CoV infection. International journal

    Fumihiko Yasui, Chieko Kai, Kousuke Saito, Shingo Inoue, Misako Yoneda, Kouichi Morita, Kyosuke Mizuno, Michinori Kohara

    Procedia in vaccinology   2 ( 1 )   44 - 50   2010

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    The precise mechanism of severe acute respiratory syndrome (SARS), which is caused by SARS-associated coronavirus (SARS-CoV), is still unclear. We generated recombinant vaccinia virus (rVV) LC16m8 strain which simultaneously expresses four structural proteins of SARS-CoV, including nucleocapsid (N), membrane (M), envelop (E), spike (S) proteins (rVV-NMES) and reported that old BALB/c mice having prior immunization with rVV-NMES develop severe pneumonia similar to those of control mice though rVV-NMES-immunized mice showed lower pulmonary viral titer than in the control mice. Furthermore, we determined which SARS-CoV structural protein for the prior rVV-immunization is responsible for the severe pneumonia after the SARS-CoV infection as observed in the rVV-NMES-immunized mice. Old BALB/c mice were inoculated intradermally with rVV that expressed each structural proteins of SARS-CoV (rVV-N, -M, -E, or -S) with or without rVV-S and then infected intranasally with SARS-CoV more than 4 weeks later. At 9 days after SARS-CoV infection, the rVV-N-immunized mice show more severe pneumonia than in other groups. Furthermore, significant up-regulation of Th1 (IL-2)- and Th2 (IL-4 and IL-5)-bias cytokines and down-regulation of anti-inflammatory cytokine (IL-10 and TGF-β) were observed in rVV-N-immunized mice, resulting in the intensive infiltration of immunocompetent cells into the lung. In contrast, rVV-S-immunized mice showed only low pulmonary viral tier and slight pneumonia. However, the mice having co-immunization with both rVV-N and rVV-S showed severe pneumonia though their pulmonary viral titer was low. These results suggest that an excessive host immune response against the N protein of SARS-CoV is involved in severe pneumonia caused by SARS-CoV infection. These findings increase our understanding of the pathogenesis of SARS.

    DOI： 10.1016/j.provac.2010.03.009

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  • ウイルス性脱髄におけるアポトーシスの役割(第2報)

    大原 義朗, 大桑 孝子, 谷浦 直子, 齊藤 峰輝, 斎藤 孔良

    臨床神経学   49 ( 12 )   1191 - 1191   2009.12

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  • HAM、ATL治療標的候補分子Bcl-3のHTLV-1感染による高発現機構の解析と制御法の検討

    齊藤 峰輝, 斎藤 孔良, 谷浦 直子, 大桑 孝子, 大原 義朗

    臨床神経学   49 ( 12 )   1068 - 1068   2009.12

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  • Hepatitis C Virus Core Protein and Cellular Protein HAX-1 Promote 5-Fluorouracil-Mediated Hepatocyte Growth Inhibition Reviewed

    Arup Banerjee, Kousuke Saito, Keith Meyer, Sutapa Banerjee, Malika Ait-Goughoulte, Ratna B. Ray, Ranjit Ray

    JOURNAL OF VIROLOGY   83 ( 19 )   9663 - 9671   2009.10

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    DOI： 10.1128/JVI.00872-09

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  • Different subcellular localization of Theiler's murine encephalomyelitis virus leader proteins of GDVII and DA strains in BHK-21 cells. Reviewed International journal

    Naoko Taniura, Mineki Saito, Takako Okuwa, Kousuke Saito, Yoshiro Ohara

    Journal of virology   83 ( 13 )   6624 - 30   2009.7

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    The highly virulent GDVII strain of Theiler's murine encephalomyelitis virus causes acute and fatal encephalomyelitis, whereas the DA strain causes mild encephalomyelitis followed by a chronic inflammatory demyelinating disease with virus persistence. The differences in the amino acid sequences of the leader protein (L) of the DA and GDVII strains are greater than those for any other viral protein. We examined the subcellular distribution of DA L and GDVII L tagged with the FLAG epitope in BHK-21 cells. Wild-type GDVII L was localized predominantly in the cytoplasm, whereas wild-type DA L showed a nucleocytoplasmic distribution. A series of the L mutant experiments demonstrated that the zinc finger domain, acidic domain, and C-terminal region of L were necessary for the nuclear accumulation of DA L. A GDVII L mutant with a deletion of the serine/threonine (S/T)-rich domain showed a nucleocytoplasmic distribution, in contrast to the predominant cytoplasmic distribution of wild-type GDVII L. A chimeric DA/GDVII L, D/G, which encodes the N region of DA L including the zinc finger domain and acidic domain, followed by the GDVII L sequence including the S/T-rich domain, was distributed exclusively throughout the cytoplasm but not in the nucleus, as observed with wild-type GDVII L. Another chimeric L, G/D (which is the converse of the D/G construct), accumulated in the nucleus as well as the cytoplasm, as was observed for wild-type DA L. The findings suggest that the differential distribution of DA L and GDVII L is determined primarily by the S/T-rich domain. The S/T-rich domain may be important for the viral activity through the regulation of the subcellular distribution of L.

    DOI： 10.1128/JVI.02385-08

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  • ウイルス性脱髄におけるアポトーシスの果たす役割

    大桑 孝子, 谷浦 直子, 齊藤 峰輝, 斎藤 孔良, 大原 義朗

    神経免疫学   17 ( 1 )   112 - 112   2009.3

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  • HTLV-1感染T細胞の機能異常をもたらす恒常的なBcl-3高発現機構の解析とその制御法の検討

    斎藤 孔良, 齊藤 峰輝, 谷浦 直子, 大桑 孝子, 大原 義朗

    神経免疫学   17 ( 1 )   117 - 117   2009.3

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  • In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) Reviewed

    Mineki Saito, Toshio Matsuzaki, Yorifumi Satou, Jun-ichirou Yasunaga, Kousuke Saito, Kimiyoshi Arimura, Masao Matsuoka, Yoshiro Ohara

    RETROVIROLOGY   6   19   2009.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/1742-4690-6-19

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  • ウイルス性脱髄におけるアポトーシスの役割

    大原 義朗, 大桑 孝子, 谷浦 直子, 齊藤 峰輝, 斎藤 孔良

    臨床神経学   48 ( 12 )   1097 - 1097   2008.12

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  • タイラーウイルスDA株のマクロファージ感染・増殖に寄与するLタンパク内領域の検索

    野尻 正史, 淺倉 慶子, 谷浦 直子, 大桑 孝子, 斎藤 孔良, 齊藤 峰輝, 大原 義朗

    金沢医科大学雑誌   33 ( 2 )   101 - 102   2008.8

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  • Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production Reviewed

    Kousuke Saito, Malika Ait-Goughoulte, Steven M. Truscott, Keith Meyer, Azra Blazevic, Getahun Abate, Ratna B. Ray, Daniel F. Hoft, Ranjit Ray

    JOURNAL OF VIROLOGY   82 ( 7 )   3320 - 3328   2008.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1128/JVI.02547-07

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  • 中枢神経系脱髄疾患 EAE動物モデルからの解析 タイラーウイルス両亜群非構成蛋白Lの細胞内局在の解析

    谷浦 直子, 齊藤 峰輝, 大桑 孝子, 斎藤 孔良, 大原 義朗

    神経免疫学   16 ( 1 )   42 - 42   2008.4

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  • Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance. Reviewed International journal

    Sutapa Banerjee, Kousuke Saito, Malika Ait-Goughoulte, Keith Meyer, Ratna B Ray, Ranjit Ray

    Journal of virology   82 ( 6 )   2606 - 12   2008.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1128/JVI.01672-07

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  • タイラーウイルスのマクロファージ内増殖におけるL及びL*蛋白の役割

    淺倉 慶子, 谷浦 直子, 大桑 孝子, 斎藤 孔良, 齊藤 峰輝, 大原 義朗

    金沢医科大学雑誌   32 ( 2 )   125 - 126   2007.8

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  • Sulfated homologues of heparin inhibit hepatitis C virus entry into mammalian cells Reviewed

    Arnab Basu, Tatsuo Kanda, Aster Beyene, Kousuke Saito, Keith Meyer, Ranjit Ray

    JOURNAL OF VIROLOGY   81 ( 8 )   3933 - 3941   2007.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1128/JVI.02622-06

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  • Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance Reviewed

    Banerjee, S, Saito, K, Ait-Goughoulte, M, Meyer, K, Ray, R. B, Ray, R

    Journal of virology   82 ( 6 )   2606 - 2012   2007

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  • Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes Reviewed

    Arnab Basu, Kousuke Saito, Keith Meyer, Ratna B. Ray, Scott L. Friedman, Yie-Hwa Chang, Ranjit Ray

    APOPTOSIS   11 ( 8 )   1391 - 1400   2006.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10495-006-8312-z

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  • Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes Reviewed

    A Basu, K Meyer, KK Lai, K Saito, AM Di Bisceglie, LE Grosso, RB Ray, R Ray

    VIROLOGY   349 ( 2 )   347 - 358   2006.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.virol.2006.02.023

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  • Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein Reviewed

    K Saito, K Meyer, R Warner, A Basu, RB Ray, R Ray

    JOURNAL OF VIROLOGY   80 ( 9 )   4372 - 4379   2006.5

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    DOI： 10.1128/JVI.80.9.4372-4379.2006

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  • Inhibition of hepatitis C virus core protein expression in immortalized human hepatocytes induces cytochrome c-independent increase in Apaf-1 and caspase-9 activation for cell death Reviewed

    K Meyer, A Basu, K Saito, RB Ray, R Ray

    VIROLOGY   336 ( 2 )   198 - 207   2005.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.virol.2005.03.016

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  • Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope Reviewed

    R Mizuta, K Iwai, M Shigeno, M Mizuta, T Uemura, T Ushiki, D Kitamura

    JOURNAL OF BIOLOGICAL CHEMISTRY   278 ( 7 )   4431 - 4434   2003.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M209262200

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  • The structure of human metaphase chromosomes: Its histological perspective and new horizons by atomic force microscopy Reviewed

    Tatsuo Ushiki, Osamu Hoshi, Kousuke Iwai, Eiji Kimura, Masatsugu Shigeno

    Archives of Histology and Cytology   65 ( 5 )   377 - 390   2002.12

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    DOI： 10.1679/aohc.65.377

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  • Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax Reviewed

    K Endo, A Hirata, K Iwai, M Sakurai, M Fukushi, M Oie, M Higuchi, WW Hall, F Gejyo, M Fujii

    JOURNAL OF VIROLOGY   76 ( 6 )   2648 - 2653   2002.3

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    DOI： 10.1128/JVI.76.6.2648-2653.2002

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  • Human T-cell leukemia virus type 1 tax protein activates transcription through AP-1 site by inducing DNA binding activity in T cells Reviewed

    K Iwai, N Mori, M Oie, N Yamamoto, M Fujii

    VIROLOGY   279 ( 1 )   38 - 46   2001.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1006/viro.2000.0669

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  • Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo Reviewed

    H. Moro, K. Iwai, N. Mori, M. Watanabe, M. Fukushi, M. Oie, M. Arai, Y. Tanaka, T. Miyawaki, F. Gejyo, M. Arakawa, M. Fujii

    Virus Genes   23 ( 3 )   263 - 271   2001

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1023/A:1012565105098

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  • Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells Reviewed

    Mori N, Fujii M, Iwai K, Ikeda S, Yamasaki Y, Hata T, Yamada Y, Tanaka Y, Tomonaga M, Yamamoto N

    BLOOD   95   3915 - 3921   2000.12

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  • Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1 Reviewed

    MI Fujii, K Iwai, M Oie, M Fukushi, N Yamamoto, M Kannagi, N Mori

    AIDS RESEARCH AND HUMAN RETROVIRUSES   16 ( 16 )   1603 - 1606   2000.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1089/08892220050193029

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Books

  • 耐性ウイルスはどのようにしてみつけるのでしょうか

    齋藤孔良（ Role： Sole author ,  インフルエンザ Vol.15 No.2, 24, 2014）

    メディカルレビュー社  2014.4 

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  • 【耐性病原体up-to-date?耐性メカニズムから治療戦略まで?】 耐性病原体 ウイルス オセルタミビル耐性インフルエンザ

    （ Role： Joint translator ,  化学療法の領域 30(増刊号) 1070-1079 2014年4月）

    医薬ジャーナル社  2014.4 

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  • ノイラミニダーゼ阻害薬の種類によって耐性ウイルスの出やすさに違いがあるのですか

    齋藤孔良（ Role： Sole author ,  インフルエンザ Vol.15 No.2, 22-23, 2014）

    メディカルレビュー社  2014.4 

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  • 耐性ウイルスの基準について教えてください

    齋藤 孔良, 高下恵美（ Role： Joint author ,  インフルエンザ 15(1) 30-30 2014年1月）

    2014.1 

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  • 原理からよくわかるリアルタイムPCR完全実験ガイド

    齋藤孔良,鈴木康司,近藤大貴,日比野亮信,齋藤玲子（ Role： Joint author ,  Ⅳ章 遺伝子量解析 薬剤耐性インフルエンザウイルスを迅速に判定する）

    羊土社  2013.10  （ ISBN:9784758101875 ）

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    Total pages：232, 6p   Language：Japanese

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  • 【新興・再興感染症up to date〜Emerging and re-emerging infectious disease〜】 ウイルス感染症 RSウイルス感染症

    齋藤 孔良, 菖蒲川 由郷, 佐野 康子, 齋藤 玲子, 鈴木 宏（ Role： Sole author ,  化学療法の領域 (Antibiotics & Chemotherapy) 29(増刊号) 1018-1026 2013年4月）

    医薬ジャーナル社  2013.3 

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  • インフルエンザ･ワクチンについて (ワクチンをめぐる最近の話題)

    齋藤 孔良, 齋藤 玲子（ Role： Joint author ,  順天堂醫事雑誌 59(1) 41-48 2013年2月）

    順天堂医学会  2013.2 

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  • 耐性インフルエンザウイルスの動向 (特集 新型インフルエンザは再びおこるか)

    齋藤 玲子, 齋藤 孔良（ Role： Joint author ,  臨床と研究 89巻12号 p1670-1675）

    大道学館出版部  2012.12 

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Presentations

  • 肺炎および肺炎球菌予防接種と認知症の関係：日本老年学的評価研究機構（JAGES）における高齢者コホート研究 Invited

    齋藤孔良

    第26回日本抗加齢医学会総会  2026.6 

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    Event date： 2026.6

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Research Projects

  • 予防接種による認知症リスク減少のメカニズムを明らかにする高齢者コホート研究

    Grant number：24K02854

    2024.4 - 2029.3

    System name：科学研究費助成事業

    Research category：基盤研究(B)

    Awarding organization：日本学術振興会

    齋藤 孔良

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    Grant amount：\18460000 （ Direct Cost: \14200000 、 Indirect Cost：\4260000 ）

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  • Study to clarify factors related to vaccine hesitancy in older adults

    Grant number：21K10323

    2021.4 - 2024.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • 血液細胞特異的な新規RasGAPによるRasシグナルの制御機構

    2016 - 2019

    System name：基盤研究(C)

    Awarding organization：新潟大学

    齋藤 孔良, 医歯学系

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • Crosstalk between stress granules and autophagy in protein degradation

    Grant number：15H04704

    2015.4 - 2018.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

    Fujii Masahiro, Komatsu Masaaki, Takahashi Masahiko, Kageyama Shun, Hara Toshifumi, Higuchi Masaya, Saito Kousuke, Koyama Akihide, Katsuragi Yoshinori, Kakihana Taichi

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    Grant amount：\16900000 （ Direct Cost: \13000000 、 Indirect Cost：\3900000 ）

    USP10 plays an important role in the formation of stress granule. I established systemic USP10-knockout (USP10-KO) mice. USP10-KO mice developed pancytopenia, and died within 300 days. This pancytopenia was completely restored by transplantation of normal bone marrows into USP10-KO mice. Furthermore, I found that apoptosis of hematopoietic stem cells is aggravated in USP10-KO mice. SCL (stem cell factor) inhibits the apoptosis of hematopoietic stem cells, but this inhibition was significantly attenuated by USP10 depletion in hematopoietic stem cells. USP10 mutants indicated that deubiquitinase activity of USP10 is critical for inhibition of apoptosis of hematopoietic stem cells. The present study suggests that USP10 and stress granules participate in the maintenance of hematopoietic stem cells.

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  • アジアを中心としたインフルエンザウイルスのグローバルな進化と薬剤耐性株の伝播追跡

    2013 - 2016

    System name：基盤研究(B)

    Awarding organization：新潟大学

    齋藤 玲子, 医歯学系

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    Grant type：Competitive

    Grant amount：\17680000 （ Direct Cost: \13600000 、 Indirect Cost：\4080000 ）

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  • 特殊環状ペプチドによるインフルエンザウイルス増殖阻害効果における作用機序解明

    2011

    System name：若手研究(B)

    Awarding organization：(財)東京都医学総合研究所

    斎藤 孔良, 東京都医学総合研究所, 研究員

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    Grant type：Competitive

    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Influenza surveillance in Myanmar: investigations on emergence of drug resistant strains and clinical pictures of H1N1pdm09

    Grant number：22406013

    2010 - 2012

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

    SAITO Reiko, NAITO Makoto, HASEGAWA Go, FUJII Masahiro, OOIE Masayasu, OOHASHI Riuko, SAITO Takehiko

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    Grant type：Competitive

    Grant amount：\18590000 （ Direct Cost: \14300000 、 Indirect Cost：\4290000 ）

    We investigated influenza viruses circulated in the community in Yangon and Nay Pyi Taw in Myanmar during FY 2010-2012. In total we isolated 643 influenza viruses during three years, and 257 were A/H1N1pdm09, 182 A/H3N2, and 204 B. Epidemic season in Myanmar was from May to November during the rainy season. For A/H3N2 and B, new genetic variants appeared a half year earlier than in Japan. Drug resistant surveillance showed that there was no oseltamivir resistant H274Y mutated strains during the years. We identified two drug resistant influenza B that conferred resistance to zanamivir and lanaimivir, and possessed I248G mutation in the NA gene.

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  • HTLV-1感染によるNF-κB活性化におけるBcl-3の意義

    Grant number：20790359

    2008 - 2010

    System name：若手研究(B)

    Research category：若手研究(B)

    Awarding organization：金沢医科大学

    斎藤 孔良, 医学部

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    Grant type：Competitive

    Grant amount：\2990000 （ Direct Cost: \2300000 、 Indirect Cost：\690000 ）

    Bcl-3のHTLV-1関連疾患への関与について明らかにすることを最終目標に、本年度は主にHTLV-1感染T細胞株を用いてT細胞の癌化及びT細胞機能異常におけるBd-3の関与を検討した。「研究計画1 : Bcl-3の恒常的NF-KB活性化への関与の有無の検討」に関しては、shRNAによるBcl-3発現挿制によってHTLV-1感染T細胞株の増殖が顕著に抑制されることを明らかにした。HTL-1感染T細胞の増殖にはNF-KB経路の活性化が重要であることがすでに報告されていることから、Bd-3の高発現が恒常的なNF-kB経路の活性化に関与する可能性がある。「研究計画2 : HTLV-1感染及びTax蛋白発現T細胞におけるBcl-3蛋白の発現調節のメカニズムの検討」に関しては、HTLV-1感染細胞内におけるBcl-3蛋白の高発現がBcl-3遺伝子のTaxによる転写活性化によってのみならず、PI3K-Akt経路の活性化によるBcl-3蛋白の分解抑制機構によっても維持されていること、Tax蛋白発現によりBcl-3蛋白の分解抑制が増強されることを明らかにした。「研究計画3 : Bcl-3蛋白発現レベルの変化とT細胞機能異常との関連の検討」に関しては、Bc1-3蛋白発現がHTLV-1感染T細胞株の異常増殖に関与することを明らかにした。今年度は以上3つの研究実施計画以外にも、HTLV-1感染T細胞内においてBcl-3がTaxと蛋白一蛋白間結合していること、さらには、Bc1-3蛋白のN, C末端領域のみからなる、すなわちAnkyrin repeatを欠く変異体がTax蛋白と効率良く結合してTaxによるHTLV-1LrRプロモーターやマトリックスメタロプロテアーゼ9プロモーターの活性化をintactなBc1-3と同等レベルで抑制するのに対して、Bd-3蛋白のN, C末端領域を欠く、すなわちAnkyrin repeat領域のみからなる変異体はTaxによるHTLV-1プロモーターの活性化をほとんど抑制しないことも明らかにした。

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Teaching Experience

  • 国際感染症制御学II

    2026
    Institution name：新潟大学

  • 生体防御と感染(総合)

    2024
    Institution name：新潟大学

  • 保健医療福祉行政論

    2022
    Institution name：新潟大学

  • 地域保健管理論

    2022
    -
    2023
    Institution name：新潟大学

  • 環日本海医療概論

    2014
    Institution name：新潟大学

 

Media Coverage

  • 2025.9.6 午後7:30放送：NHK総合「知的探求フロンティア タモリ・山中伸弥の！？」 TV or radio program

    NHK総合  知的探求フロンティア タモリ・山中伸弥の！？ 第2回「認知症 克服のカギ」  2025.9

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    認知症は克服できる！？タモリ、山中伸弥らが研究の最前線を深掘り＆認知症関連番組も

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  • 肺炎球菌ワクチン接種で認知症の発症２割減（新潟大研究班） Internet

    福祉新聞WEB  2024.9

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    新潟大の研究班は８月３０日、肺炎球菌ワクチンを接種した高齢者は認知症の発症が２割以上少ないとする研究結果を発表した。要介護認定を受けていない高齢者約１万人を対象に３年半追跡調査した。

    近年、肺炎球菌とインフルエンザのワクチンを接種した高齢者の認知症は、未接種の高齢者より少ないという報告が増えており、どちらのワクチンが認知症と関係があるかを調べた。肺炎球菌ワクチンを接種した高齢者の認知症は２３％少なく、インフルエンザワクチンは接種有無で差はなかった。

    研究班は「ワクチン接種がどのように認知症予防に効果を発揮するかについて、脳神経や免疫のメカニズムを明らかにする必要がある」としている。

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  • 「認知症」はワクチン接種で防げる!? 肺炎球菌ワクチンでリスク減少 調査で明らかに Internet

    Medical DOC  2024.9

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    Author：Other 

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  • 肺炎球菌ワクチン接種の高齢者で認知症減少－新潟大ほか Internet

    QLife  QLifePro  2024.9

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    Author：Other 

    新潟大学は9月4日、約1万人の高齢者を3年半追跡し、肺炎球菌ワクチンを接種していた人では接種しなかった人と比べ認知症が23％少なかったことを明らかにしたと発表した。この研究は、同大大学院医歯学総合研究科国際保健学分野の齋藤孔良助教、藤井雅寛名誉教授、慶應義塾大学の佐藤豪竜専任講師、千葉大学の近藤克則特任教授らの研究グループによるもの。研究成果は、「Brain, Behavior, and Immunity」に掲載されている。

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  • 新大、肺炎球菌ワクチンの接種が認知症になりにくくすることを発見 Internet

    マイナビ  Techプラス  2024.9

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    Author：Other 

    新潟大学(新大)は9月4日、約1万人の高齢者を3年半追跡し、肺炎球菌ワクチンを接種していた人では接種しなかった人と比べ認知症が23％少なかったことがわかり、その一方で、インフルエンザワクチンでは、接種した人と接種しなかった人の間で認知症発症に差は認められなかったと発表した。

    同成果は、新大大学院 医歯学総合研究科 国際保健学分野の齋藤孔良助教、同・大学の藤井雅寛名誉教授、慶應義塾大学の佐藤豪竜専任講師、千葉大学の近藤克則特任教授らの共同研究チームによるもの。詳細は、ヒトと動物の行動・神経・内分泌・免疫系の相互作用を扱った学術誌「Brain, Behavior, and Immunity」に掲載された。

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  • 重い介護負担で高齢者のインフルエンザ予防接種が減少 かかりつけ医による接種の勧めが効果的 Internet

    日本・医療健康情報研究所  糖尿病リソースガイド  2023.12

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    高齢者による介護(老老介護)の負担が社会問題化している。「ほぼ毎日介護」あるいは「ほぼ１日中介護」をしている高齢者では、介護をしていない高齢者に比べ、インフルエンザの予防接種が６割少ないことが、日本の高齢者2万6,177人を対象とした新潟大学の調査で明らかになった。
    「高齢者の重い介護負担は、インフルエンザ予防接種の妨げになっている可能性が明らかになりました。かかりつけ医によるワクチン接種の勧めが、介護を行なっている高齢者のワクチン接種を促進するために重要と考えられます」と、研究者は述べている。

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  • 高齢者による「老老介護」が社会問題に 重い介護負担で高齢者のインフルエンザ予防接種が６割減少 Internet

    日本医療・健康情報研究所／創新社  保健指導リソースガイド  2023.12

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    Author：Other 

    高齢者による介護(老老介護)の負担が社会問題化している。「ほぼ毎日介護」あるいは「ほぼ１日中介護」をしている高齢者では、介護をしていない高齢者に比べ、インフルエンザの予防接種が６割少ないことが、日本の高齢者2万6,177人を対象とした新潟大学の調査で明らかになった。
    「高齢者の重い介護負担は、インフルエンザ予防接種の妨げになっている可能性が明らかになりました。かかりつけ医によるワクチン接種の勧めが、介護を行なっている高齢者のワクチン接種を促進するために重要と考えられます」と、研究者は述べている。

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  • フレイルのある高齢者はインフルエンザに1.4倍かかりやすい 重症化リスクも3.2倍 高齢男性でとくに深刻 Internet

    保健指導リソースガイド  2023.10

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    フレイルのある高齢者では、健康な高齢者に比べ、インフルエンザに1.4倍かかりやすく、3.2倍重症化しやすいことが、日本の高齢者7.7万人を対象とした調査で明らかになった。

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  • フレイルのある高齢者はインフルエンザに1.4倍かかりやすい 重症化リスクも3.2倍 Internet

    一般社団法人 日本肥満症予防協会  2023.10

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    Author：Other 

    フレイルのある高齢者では、健康な高齢者に比べ、インフルエンザに1.4倍かかりやすく、3.2倍重症化しやすいことが、日本の高齢者7.7万人を対象とした調査で明らかになった。
    フレイルのある高齢者は、肺炎に2倍かかりやすく、重症化もしやすいことも分かった。
    高齢者のインフルエンザや肺炎の予防・対策では、フレイルの予防・改善も重要であることが示された。

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  • 「フレイル」高齢者、インフル重症化リスク３・２倍…免疫弱い可能性（読者会員限定） Internet

    読売新聞オンライン  2023.8

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  • 「フレイル」の高齢者 インフルエンザに1.36倍感染しやすく重症化も3.18倍 Internet

    メーテレ  2023.6

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    Author：Other 

    高齢者のなかでも加齢によって心身が弱ったいわゆる「フレイル」の人は健康な人と比べて季節性インフルエンザにかかりやすく、重症化しやすいことが分かりました。 新潟大学の齋藤孔良助教らの研究チームは、高齢者およそ7万7000人を対象にインフルエンザに感染したかどうかを調べました。 その結果、心と身体が衰え、要介護状態の手前にある「フレイル」の高齢者は健康な人と比べて1.36倍インフルエンザにかかりやすいことが分かりました。 また、感染した際に3.18倍、重症化しやすいことも明らかになったということです。 これまで高齢者がインフルエンザに感染した場合、重症化しやすいことは明らかになっていましたが、「フレイル」との関係は分かっていませんでした。 齋藤助教は「フレイル」の高齢者には「感染につながる行動はなるべく避け、ワクチンを接種してほしい」と呼び掛けています。

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  • 「フレイル」の高齢者 インフルエンザに1.36倍感染しやすく重症化も3.18倍 Internet

    テレ朝ニュース  テレビ朝日  2023.6

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    Author：Other 

    高齢者のなかでも加齢によって心身が弱ったいわゆる「フレイル」の人は健康な人と比べて季節性インフルエンザにかかりやすく、重症化しやすいことが分かりました。

    新潟大学の齋藤孔良助教らの研究チームは、高齢者およそ7万7000人を対象にインフルエンザに感染したかどうかを調べました。

    その結果、心と身体が衰え、要介護状態の手前にある「フレイル」の高齢者は健康な人と比べて1.36倍インフルエンザにかかりやすいことが分かりました。

    また、感染した際に3.18倍、重症化しやすいことも明らかになったということです。

    これまで高齢者がインフルエンザに感染した場合、重症化しやすいことは明らかになっていましたが、「フレイル」との関係は分かっていませんでした。

    齋藤助教は「フレイル」の高齢者には「感染につながる行動はなるべく避け、ワクチンを接種してほしい」と呼び掛けています。

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  • 堀ちゃんと学ぶフレイル予防 TV or radio program

    テレビ新潟  2022.2

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  • 高齢者の肺炎球菌予防接種率、「ソーシャルキャピタル」がある人で高い－新潟大 Internet

    (株)QLife  医療ニュース QLife pro  2021.9

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    助成金以外でワクチン接種率の向上につながる方法は？
    新潟大学は9月6日、約18万人の65歳以上の高齢者を対象に調査し、「ソーシャルキャピタル」がある高齢者では、肺炎球菌の予防接種を受けている人が多いことが明らかになったと発表した。この研究は、同大大学院医歯学総合研究科国際保健学分野の齋藤孔良助教らの研究グループによるもの。研究成果は、「BMJ Open」に掲載されている。

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  • フレイルがある高齢者は肺炎に1.9倍かかりやすく、1.8倍重症化しやすい 予備群でも肺炎リスクは1.3倍 Internet

    糖尿病リソースガイド  2021.8

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    Author：Other 

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  • Older adults with frailty are 1.9 times more susceptible to pneumonia and 1.8 times more likely to develop severe disease -Niigata University Internet

    2021年07月30日 AM10:52  2021.7

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  • フレイル高齢者は1.9倍肺炎にかかりやすく、1.8倍重症化しやすい

    ティースデンタルオフィス  2021.7

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    Author：Other 

    フレイルとは、加齢や病気による心身の衰えにより要介護になるリスクが高い状態をいいます。新潟大学大学院医歯学総合研究科国際保健学分野の齋藤孔良助教らの研究グループは、約１８万人の65歳以上の高齢者における疫学調査を行いました。
    その結果、フレイルの65歳以上の高齢者では、フレイル無しの高齢者と比べて約1.9倍肺炎にかかりやすく、また、1.8倍肺炎が重症化しやすい（入院措置になりやすい）ことを明らかにしました。またフレイルの前段階にある高齢者でも、フレイル無しの高齢者と比べて1.3倍肺炎にかかりやすいことがわかりました。

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