2022/01/27 更新

写真a

キタムラ カオリ
北村 香織
KITAMURA Kaori
所属
教育研究院 医歯学系 医学系列 助教
医学部 医学科 助教
医歯学総合研究科 地域疾病制御医学専攻 地域予防医学 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2013年3月   新潟大学 )

研究キーワード

  • 認知症

  • 予防医学

  • 公衆衛生学

  • 疫学

  • 地域保健

研究分野

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

  • ライフサイエンス / 医療管理学、医療系社会学

  • ライフサイエンス / 高齢者看護学、地域看護学

▶ 全件表示

経歴(researchmap)

  • 新潟大学   医学部 医学科   助教

    2013年4月 - 現在

      詳細を見る

  • 新潟大学   医歯学総合研究科 地域疾病制御医学専攻 地域予防医学   助教

    2013年4月 - 現在

      詳細を見る

  • 新潟大学   医歯学総合研究科   特任助教

    2012年2月 - 2013年3月

      詳細を見る

経歴

  • 新潟大学   医学部 医学科   助教

    2013年4月 - 現在

  • 新潟大学   医歯学総合研究科 地域疾病制御医学専攻 地域予防医学   助教

    2013年4月 - 現在

  • 新潟大学   医歯学総合研究科   特任助教

    2012年2月 - 2013年3月

学歴

  • 新潟大学   医学系研究科

    2010年4月 - 2013年3月

      詳細を見る

    国名: 日本国

    researchmap

所属学協会

取得資格

  • 保健師

 

論文

  • Menstrual and reproductive factors and limitations in activities of daily living: A case–control study within the Japan Public Health Center‐based Prospective Study 査読

    Kazutoshi Nakamura, Norie Sawada, Kaori Kitamura, Yumi Watanabe, Shoichiro Tsugane

    Journal of Obstetrics and Gynaecology Research   2021年9月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/jog.14959

    researchmap

    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jog.14959

  • Short daytime napping reduces the risk of cognitive decline in community-dwelling older adults: a 5-year longitudinal study 査読

    Kaori Kitamura, Yumi Watanabe, Kazutoshi Nakamura, Chikako Takano, Naomi Hayashi, Hisami Sato, Toshiyuki Someya

    BMC Geriatrics   21 ( 1 )   2021年8月

     詳細を見る

    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    <title>Abstract</title><sec>
    <title>Background</title>
    Beneficial effects of napping on cognition have been suggested in cross-sectional studies. This study aimed to clarify longitudinal associations between cognitive decline and sleep characteristics, particularly daytime napping, over a 5-year period in older adults.


    </sec><sec>
    <title>Methods</title>
    Study participants were 389 community-dwelling individuals aged ≥65 years living in Ojiya City, Niigata, Japan. Baseline and follow-up examinations were conducted in 2011–2013 and 2016–2018, respectively. Trained nurses visited and interviewed participants to collect the following information at baseline and follow-up: demographic characteristics, disease history, lifestyle habits including bedtime, sleeping hours, and daytime nap duration, and cognitive function. The assessment of cognitive function was performed using the revised Hasegawa’s dementia scale (HDS-R), with cognitive decline defined as a change in the HDS-R of ≤ − 3 over 5 years. Odds ratios (ORs) for cognitive decline were calculated using multiple logistic regression analysis.


    </sec><sec>
    <title>Results</title>
    Mean age of participants was 74.6 years (SD 6.4), and the cumulative incidence of cognitive decline was 106/389 (27.3%). The adjusted OR for 1–29 min daytime napping was significantly lower compared to that for no napping (OR = 0.47, 95%CI: 0.23–0.96). Earlier bedtime was associated with cognitive decline (adjusted P for trend = 0.0480).


    </sec><sec>
    <title>Conclusion</title>
    Short daytime napping (&lt; 30 min) reduces the risk of cognitive decline over 5 years for community-dwelling older people. A future study will be necessary to confirm the effect of short napping on the reduction of risk for clinically diagnosed dementia.


    </sec>

    DOI: 10.1186/s12877-021-02418-0

    researchmap

    その他リンク: https://link.springer.com/article/10.1186/s12877-021-02418-0/fulltext.html

  • Association of coffee;green tea;caffeine with;the risk of;dementia in;older;Japanese people 査読

    Matsushita N, Nakanishi Y, Watanabe Y, Kitamura K, Kabasawa K, Takahashi A, Saito T, Kobayashi R, Takachi R, Oshiki R, Tsugane S, Iki M, Sasaki A, Yamazaki O, Watanabe K, Nakamura, K

    J Am Geriatr Soc. in press.   2021年7月

     詳細を見る

  • Serum 25-hydroxyvitamin D levels are not associated with impaired postural sway in community-dwelling older women: a 6-year follow-up study. 査読

    Nakamura K, Saito T, Takahashi A, Kobayashi R, Oshiki R, Kitamura K, Watanabe Y

    J Musculoskelet Neuronal Interact. in press.   2021年7月

     詳細を見る

  • Body mass index and risk of recurrent falls in community‐dwelling Japanese aged 40–74 years: The Murakami cohort study 査読

    Kazutoshi Nakamura, Kaori Kitamura, Yumi Watanabe, Keiko Kabasawa, Akemi Takahashi, Aya Hinata, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Ribeka Takachi, Shoichiro Tsugane, Masayuki Iki, Ayako Sasaki, Osamu Yamazaki, Kei Watanabe

    Geriatrics & Gerontology International   21 ( 6 )   498 - 505   2021年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    AIMS: A prior meta-analysis found that obesity (body mass index [BMI] ≥ 30 kg/m2 ) was associated with a high fall risk, while being overweight (BMI≥25, <30 kg/m2 ) was associated with the lowest fall risk. However, whether these associations hold true for East Asians is unknown. This study aimed to assess the association between BMI and incidence of recurrent falls in Japanese aged 40-74 years. METHODS: This 5-year follow-up cohort study involved 7538 community-dwelling individuals who did not experience recurrent falls in the year before the baseline study. Information on demographics, body size, lifestyle, and disease history was obtained using a self-administered questionnaire. BMI was categorized as <18.5 (underweight), 18.5-20.6 (low-normal), 20.7-22.7 (mid-normal, reference), 22.8-24.9 (high-normal), and ≥ 25.0 kg/m2 (overweight). The outcome was recurrent falls reported, and fall history in the previous year was recorded as none, once, or twice or more (recurrent falls). RESULTS: Mean BMI was 23.5 kg/m2 (SD 2.9) for men and 22.7 kg/m2 (SD 3.2) for women. The adjusted odds ratio (OR) for recurrent falls in the BMI ≥25 group was significantly higher (1.41, 95%CI: 1.02-1.93) than that in the reference group. The adjusted OR in the BMI ≥25 group was significantly higher than that in the reference group for the age ≥ 60 subgroup (1.62, 95%CI: 1.09-2.40), but not for the age < 60 subgroup (OR = 1.04, 95%CI: 0.60-1.80). CONCLUSIONS: Being overweight may be a risk factor for recurrent falls in community-dwelling older Japanese. Further studies are needed to determine the underlying mechanism. Geriatr Gerontol Int 2021; 21: 498-505.

    DOI: 10.1111/ggi.14167

    PubMed

    researchmap

    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ggi.14167

  • Associations of physical activity in rural life with happiness and ikigai: a cross-sectional study 査読

    Keiko Kabasawa, Junta Tanaka, Yumi Ito, Kinya Yoshida, Kaori Kitamura, Shoichiro Tsugane, Kazutoshi Nakamura, Ichiei Narita

    Humanities and Social Sciences Communications   8 ( 1 )   2021年2月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    <title>Abstract</title>Physical activity is associated with subjective well-being. In rural communities, however, physical activity may be affected by environmental factors (e.g., nature and socioecological factors). We examined the association of two physical activities in rural life (farming activity and snow removal) with subjective well-being in terms of happiness and <italic>ikigai</italic> (a Japanese word meaning purpose in life). In this cross-sectional study, we analysed data collected from community-dwelling adults aged ≥ 40 years in the 2012–2014 survey of the Uonuma cohort study, Niigata, Japan. Happiness (<italic>n</italic> = 31,848) and <italic>ikigai</italic> (<italic>n</italic> = 31,785) were evaluated with respect to farming activity from May through November and snow removal from December through April by using an ordinal logistic regression model with adjustments for potential confounders. The analyses were conducted in 2019. Among the participants who reported some farming or snow-removal time, median farming and snow-removal time (minutes per day) was 90.0 and 64.3 for men and 85.7 and 51.4 for women, respectively. Ordinal logistic regression analysis showed that longer time farming was associated with greater happiness and <italic>ikigai</italic> in men (adjusted odds ratio for first vs. fourth quartile: happiness = 1.17, 95% confidence interval [CI] = 1.01, 1.35; <italic>ikigai</italic> = 1.29, 95% CI = 1.10, 1.50), and also in women (adjusted odds ratio for first vs. fourth quartile: happiness = 1.17, 95% CI = 1.001, 1.36; <italic>ikigai</italic> = 1.42, 95% CI = 1.20, 1.67). More snow-removal time was inversely associated with happiness and with <italic>ikigai</italic> in women only (adjusted odds ratio for first vs. fourth quartile: happiness = 0.75, 95% CI = 0.67, 0.85; <italic>ikigai</italic> = 0.78, 95% CI = 0.69, 0.88). Our findings showed that physical activity in rural life was associated with happiness and with <italic>ikigai</italic>, and gender differences were observed in their associations with more snow-removal time. These results may be useful in helping to identify people in rural communities who are vulnerable in terms of psychological well-being.

    DOI: 10.1057/s41599-021-00723-y

    researchmap

    その他リンク: http://www.nature.com/articles/s41599-021-00723-y

  • A 5-year longitudinal association between dietary fermented soya bean (natto) intake and tooth loss through bone mineral density in postmenopausal women: The Yokogoshi cohort study. 査読 国際誌

    Masanori Iwasaki, Misuzu Sato, Akihiro Yoshihara, Toshiko Saito, Kaori Kitamura, Toshihiro Ansai, Kazutoshi Nakamura

    Gerodontology   38 ( 3 )   267 - 275   2020年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: In this 5-year cohort study, we aimed to determine whether the intake of natto, a fermented soya bean food product, has an indirect effect on tooth loss incidence through BMD changes among postmenopausal women. BACKGROUND: Evidence indicates (1) that natto has a beneficial effect on bone health and (2) that a decrease in bone mineral density (BMD) is associated with tooth loss. METHODS: The study recruited 435 postmenopausal women (average age = 64.2 years). Natto intake (exposure) was assessed at baseline using a food frequency questionnaire. Lumbar spine BMD and number of teeth were measured at baseline and 5-year follow-up. BMD change (mediator) and the number of teeth lost (outcome) over time were calculated. The mediation model consisted of these 3 variables. Mediation analysis was performed to test the indirect effect of the natto intake measured through BMD change on tooth loss. RESULTS: During the study, the mean number of teeth lost was 1.2 (standard deviation = 1.8), and the mean BMD decline was 2.5% (standard deviation = 7.1). After adjusting for potential confounders, increasing habitual natto intake was significantly indirectly associated with a lower incidence of tooth loss mediated by BMD change (incidence rate ratio of tooth loss among women with "≥1 pack/day" natto intake was 0.90 [95% confidence interval = 0.82-0.99] compared to those with natto consumption of "rarely"). CONCLUSIONS: Dietary natto intake is significantly indirectly associated with a lower incidence of tooth loss among postmenopausal women, and systemic bone density could be a mediator of this association.

    DOI: 10.1111/ger.12523

    PubMed

    researchmap

  • 地域在住高齢者の認知機能低下予防プログラムの開発

    北村 香織, 佐藤 久美, 林 直美, 渡邊 裕美, 中村 和利

    木村看護教育振興財団看護研究集録   ( 27 )   36 - 60   2020年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公財)木村看護教育振興財団  

    地域高齢者の認知機能低下に関わる要因を明らかにするため、小千谷市の3地区に在住する高齢者で要支援・要介護認定を受けていない592名に面接調査を行い、その結果をもとに、科学的根拠に基づく認知機能低下予防プログラムを開発した。同プログラムを用いて認知機能低下予防教室を開催し、そのさい教育媒体として「生活習慣チェック用紙」を使用するとともに、面談時に「K10調査票」を用いてストレスの評価を行うこととした。さらに、教室終了後に面談結果をスタッフ間で検討することでハイリスク者を抽出し、個別支援を継続的に実施することとした。

    researchmap

  • Urinary Apolipoprotein C3 Is a Potential Biomarker for Alzheimer’s Disease 査読

    Yumi Watanabe, Yoshitoshi Hirao, Kensaku Kasuga, Takayoshi Tokutake, Kaori Kitamura, Shumpei Niida, Takeshi Ikeuchi, Kazutoshi Nakamura, Tadashi Yamamoto

    Dementia and Geriatric Cognitive Disorders Extra   10 ( 3 )   94 - 104   2020年9月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:S. Karger AG  

    &lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Biomarkers of Alzheimer’s disease (AD) that can easily be measured in routine health checkups are desirable. Urine is a source of biomarkers that can be collected easily and noninvasively. We previously reported on the comprehensive profile of the urinary proteome of AD patients and identified proteins estimated to be significantly increased or decreased in AD patients by a label-free quantification method. The present study aimed to validate urinary levels of proteins that significantly differed between AD and control samples from our proteomics study (i.e., apolipoprotein C3 [ApoC3], insulin-like growth factor-binding protein 3 [Igfbp3], and apolipoprotein D [ApoD]). &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Enzyme-linked immunosorbent assays (ELISAs) were performed using urine samples from the same patient and control groups analyzed in the previous proteomics study (18 AD and 18 controls, set 1) and urine samples from an independent group of AD patients and controls (13 AD, 5 mild cognitive impairment [MCI], and 32 controls) from the National Center for Geriatrics and Gerontology Biobank (set 2). &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; In set 1, the crude urinary levels of ApoD, Igfbp3, and creatinine-adjusted ApoD were significantly higher in the AD group relative to the control group (&lt;i&gt;p&lt;/i&gt; = 0.003, &lt;i&gt;p&lt;/i&gt; = 0.002, and &lt;i&gt;p&lt;/i&gt; = 0.019, respectively), consistent with our previous proteomics results. In set 2, however, the crude urinary levels of Igfbp3 were significantly lower in the AD+MCI group than in the control group (&lt;i&gt;p&lt;/i&gt; = 0.028), and the levels of ApoD and ApoC3 did not differ significantly compared to the control group. Combined analysis of all samples revealed creatinine-adjusted ApoC3 levels to be significantly higher in the AD+MCI group (&lt;i&gt;p&lt;/i&gt; = 0.015) and the AD-only group (&lt;i&gt;p&lt;/i&gt; = 0.011) relative to the control group. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; ApoC3 may be a potential biomarker for AD, as validated by ELISA. Further analysis of ApoC3 as a urinary biomarker for AD is warranted.

    DOI: 10.1159/000509561

    researchmap

  • Predictors of decline in vitamin D status in middle-aged and elderly individuals: a 5-year follow-up study. 査読 国際誌

    Kazutoshi Nakamura, Kaori Kitamura, Yumi Watanabe, Toshiko Saito, Akemi Takahashi, Ryosaku Kobayashi, Rieko Oshiki, Keiko Kabasawa, Ribeka Takachi, Shoichiro Tsugane, Masayuki Iki, Ayako Sasaki, Kei Watanabe

    The British journal of nutrition   124 ( 7 )   1 - 7   2020年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Little is known about predictors of decline in vitamin D status (vitamin D decline) over time. We aimed to determine demographic and lifestyle variables associated with vitamin D decline by sufficiently controlling for seasonal effects of vitamin D uptake in a middle-aged to elderly population. Using a longitudinal study design within the larger framework of the Murakami Cohort Study, we examined 1044 individuals aged between 40 and 74 years, who provided blood samples at baseline and at 5-year follow-up, the latter of which were taken on a date near the baseline examination (±14 d). Blood 25-hydroxyvitamin D (25(OH)D) concentrations were determined with the Liaison® 25OH Vitamin D Total Assay. A self-administered questionnaire collected demographic, body size and lifestyle information. Vitamin D decline was defined as the lowest tertile of 5-year changes in blood 25(OH)D (Δ25(OH)D) concentration (<6·7 nmol/l). Proportions of those with vitamin D decline were 182/438 (41·6 %) in men and 166/606 (27·4 %) in women (P < 0·0001). In men, risk of vitamin D decline was significantly lower in those with an outdoor occupation (P = 0·0099) and those with the highest quartile of metabolic equivalent score (OR 0·34; 95 % CI 0·14, 0·83), and higher in those with 'university or higher' levels of education (OR 2·92; 95 % CI 1·04, 8·19). In women, risk of vitamin D decline tended to be lower with higher levels of vitamin D intake (Pfor trend = 0·0651) and green tea consumption (Pfor trend = 0·0025). Predictors of vitamin D decline differ by sex, suggesting that a sex-dependent intervention may help to maintain long-term vitamin D levels.

    DOI: 10.1017/S0007114520001580

    PubMed

    researchmap

  • Dietary calcium and vitamin K are associated with osteoporotic fracture risk in middle-aged and elderly Japanese women, but not men: the Murakami Cohort Study. 査読 国際誌

    Kseniia Platonova, Kaori Kitamura, Yumi Watanabe, Ribeka Takachi, Toshiko Saito, Keiko Kabasawa, Akemi Takahashi, Ryosaku Kobayashi, Rieko Oshiki, Aleksandr Solovev, Masayuki Iki, Shoichiro Tsugane, Ayako Sasaki, Osamu Yamazaki, Kei Watanabe, Kazutoshi Nakamura

    The British journal of nutrition   125 ( 3 )   1 - 25   2020年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Although dietary calcium, vitamin D, and vitamin K are nutritional factors associated with osteoporosis, little is known about their effects on incident osteoporotic fractures in East Asian populations. This study aimed to determine whether intakes of these nutrients predict incident osteoporotic fractures. We adopted a cohort-study design with a 5-year follow-up. Subjects were 12,794 community-dwelling individuals (6,301 men and 6,493 women) aged 40-74 years. Dietary intakes of calcium, vitamin D, and vitamin K were assessed with a validated food frequency questionnaire. Covariates were demographic and lifestyle factors. All incident cases of major osteoporotic limb fractures, including those of the distal forearm, neck of humerus, neck or trochanter of femur, and lumbar or thoracic spine were collected. Hazard ratios (HRs) for energy-adjusted calcium, vitamin D, and vitamin K were calculated with the residual method. Mean age was 58.8 years (SD=9.3). Lower energy-adjusted intakes of calcium and vitamin K in women were associated with higher adjusted HRs of total fractures (P for trend=0.005 and 0.08, respectively). When vertebral fracture was the outcome, P for trend values for calcium and vitamin K were 0.03 and 0.006, respectively, and HRs of the lowest and highest (reference) intake groups were 2.03 (95%CI:1.08-3.82) and 2.26 (95%CI:1.19-4.26), respectively. In men, there were null associations between incident fractures and each of the three nutrient intakes. Lower intakes of dietary calcium and vitamin K were independent, lifestyle-related risk factors for osteoporotic fracture in women but not men. These associations were robust for vertebral fractures, but not for limb fractures.

    DOI: 10.1017/S0007114520001567

    PubMed

    researchmap

  • Total physical activity and risk of chronic low back and knee pain in middle-aged and elderly Japanese people: The Murakami cohort study. 査読 国際誌

    Aleksandr Solovev, Yumi Watanabe, Kaori Kitamura, Akemi Takahashi, Ryosaku Kobayashi, Toshiko Saito, Ribeka Takachi, Keiko Kabasawa, Rieko Oshiki, Kseniia Platonova, Shoichiro Tsugane, Masayuki Iki, Ayako Sasaki, Osamu Yamazaki, Kei Watanabe, Kazutoshi Nakamura

    European journal of pain (London, England)   24 ( 4 )   863 - 872   2020年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Specific components of physical activity, such as vigorous exercise and heavy occupational work, are known to increase the risk of chronic low back pain (CLBP) and chronic knee pain (CKP), but impacts of other components are less known. This study aimed to assess the relationship between total physical activity and risk of CLBP and CKP from a public health perspective. METHODS: Participants were 7,565 individuals, aged 40-74 years, who did not have CLBP or CKP, and who participated in the 5-year follow-up survey. A self-administered questionnaire was used to obtain information on demographics, body size and lifestyle (including physical activity) in the baseline survey in 2011-2013, and on CLBP and CKP using Short Form 36 (SF-36) in the follow-up survey. Sitting, standing, walking and strenuous work for occupational activity were assessed for total physical activity, and walking slowly, walking quickly, light to moderate exercise and strenuous exercise were assessed for leisure-time physical activity using metabolic equivalent hours/day (METs score). RESULTS: Mean age of participants was 60.1 years (SD, 8.8). Participants with higher METs scores had a significantly higher risk of CKP (p for trend = 0.0089, OR of 4th quartile = 1.29, 95% CI: 1.04-1.59 vs. 1st quartile), but not CLBP. An intermediate leisure-time METs score was associated with a lower risk of CLBP (OR = 0.75, 95%CI: 0.61-0.92 vs. 0 METs-group). CONCLUSIONS: A high level of total physical activity may increase the risk of CKP, whereas an intermediate level of leisure-time physical activity may decrease the risk of CLBP, in middle-aged and elderly individuals. SIGNIFICANCE: Evidence on the longitudinal association between total physical activity and CLBP and CKP in middle-aged and elderly people is lacking. We conducted a cohort study to assess this association, and found that high levels of total physical activity increased risk of CKP, and intermediate levels of leisure-time physical activity decreased risk of CLBP. This suggests that the effect of physical activity on chronic pain differed by pain site.

    DOI: 10.1002/ejp.1535

    PubMed

    researchmap

  • Psychological distress as a risk factor for dementia after the 2004 Niigata-Chuetsu earthquake in Japan. 査読 国際誌

    Kazutoshi Nakamura, Yumi Watanabe, Kaori Kitamura, Keiko Kabasawa, Toshiyuki Someya

    Journal of affective disorders   259   121 - 127   2019年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: A large earthquake can cause extreme stress and may adversely affect cognitive function in humans. We aimed to examine a possible association between psychological distress and incident dementia after the 2004 Niigata-Chuetsu earthquake in Japan. METHODS: This is a retrospective cohort study followed participants for 10-12 years. Subjects were 6,012 residents in 2005, 5,424 in 2006, and 5,687 in 2007 (age ≥40 years) living in Ojiya city who participated in the annual health check examinations after the 2004 Niigata-Chuetsu earthquake. Psychological distress was assessed using the Kessler Psychological Distress Scale (K10), and individuals with a K10 score ≥10 were considered to have psychological distress. Incident dementia cases were identified from a long-term care insurance database of the local government during the follow-up period. We evaluated hazard ratios (HRs) of psychological distress for incident dementia in each year, unadjusted and adjusted for covariates, including sex, age, occupation, BMI, and property damage of residential area. RESULTS: The average age of the subjects was 64.6 years in 2005, 64.6 in 2006, and 65.2 in 2007. Adjusted HRs were significantly higher (HR = 1.20-1.66) in the psychological distress group than in the reference group in each year. In particular, adjusted HR was high (HR = 2.89) in those with psychological distress in all three years (2005-2007). CONCLUSION: Psychological distress, especially persistent distress, is a risk factor for incident dementia in victims of large disasters.

    DOI: 10.1016/j.jad.2019.08.041

    PubMed

    researchmap

  • Modifiable factors associated with symptomatic knee osteoarthritis: The Murakami cohort study. 査読 国際誌

    Ryoya Takiguchi, Rintaro Komatsu, Kaori Kitamura, Yumi Watanabe, Akemi Takahashi, Ryosaku Kobayashi, Rieko Oshiki, Toshiko Saito, Keiko Kabasawa, Ribeka Takachi, Shoichiro Tsugane, Masayuki Iki, Ayako Sasaki, Osamu Yamazaki, Kazutoshi Nakamura

    Maturitas   128   53 - 59   2019年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Modifiable risk factors for knee osteoarthritis (OA) have not been studied in detail. This study aimed to determine lifestyle-related modifiable factors of symptomatic knee osteoarthritis in an East Asian population. STUDY DESIGN: This 5-year cohort study involved 11,091 individuals (age range 40-72 years) living in the Murakami region of Niigata, Japan, who did not have a history of knee OA. At baseline, information on sociodemographic characteristics, body size, lifestyle, and living condition was obtained using a self-administered questionnaire. MAIN OUTCOME MEASURES: Incident symptomatic knee OA observed at hospitals and orthopaedic clinics in the five years to 2016. Clinical grades of knee OA were based on the Kellgren-Lawrence scale. P for trend was assessed to examine linear associations between predictors and the outcome in multiple logistic regression analysis. RESULTS: The mean age of participants was 58.1 (SD 9.3) years. The number of cases of grade 2 or more incident knee OA was 429. In men, older age (P for trend < 0.0001), higher BMI (P for trend < 0.0001), higher METs score (P for trend = 0.0150), less smoking (P for trend = 0.0249), and lower green tea consumption (P for trend = 0.0437) were associated with incident knee OA. In women, older age (P for trend < 0.0001), higher BMI (P for trend < 0.0001), and alcohol consumption (P = 0.0153) were associated with incident knee OA. CONCLUSIONS: Several lifestyle-related factors were found to be associated with incident knee OA and exhibited sex-dependent differences. In particular, higher consumption of green tea was associated with a lower incidence of knee OA in men.

    DOI: 10.1016/j.maturitas.2019.06.013

    PubMed

    researchmap

  • Low serum 25-hydroxyvitamin D is associated with low grip strength in an older Japanese population. 査読

    Kitsu T, Kabasawa K, Ito Y, Kitamura K, Watanabe Y, Tanaka J, Nakamura K, Narita I

    Journal of bone and mineral metabolism   38 ( 2 )   198 - 204   2019年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00774-019-01040-w

    PubMed

    researchmap

  • Food frequency questionnaire reproducibility for middle-aged and elderly Japanese

    Koutatsu Maruyama, Ai Ikeda, Junko Ishihara, Ribeka Takachi, Norie Sawada, Taichi Shimazu, Kazutoshi Nakamura, Junta Tanaka, Taiki Yamaji, M. Iwasaki, Hiroyasu Iso, Shoichiro Tsugane, K. Kito, T. Komata, S. Tsugane, M. Inoue, S. Sasazuki, M. Iwasaki, N. Sawada, T. Yamaji, T. Shimazu, H. Charvat, A. Noda, A. Hara, Mishiro, I, Y. Ishii, Y. Shinozawa, J. Umezawa, T. Takahashi, Y. Ito, K. Kobayashi, H. Iso, J. Ishihara, K. Nakamura, J. Tanaka, K. Kitamura, R. Takachi

    ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION   28 ( 2 )   362 - 370   2019年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:H E C PRESS, HEALTHY EATING CLUB PTY LTD  

    Background and Objectives: The aim of this study was to examine the reproducibility of a self-administered food frequency questionnaire (FFQ) originally developed for the Japan Public Health Center-Based Prospective Study (JPHC study) and modified for use in the Next Generation (JPHC-NEXT) study. Methods and Study Design: Participants included 98 men and 142 women aged 40-74 years from the five areas included in the JPHC-NEXT protocol. In November 2012, participants were recruited and asked to complete the first nutrition survey. The second nutrition survey was completed after 1 year. Results: We estimated daily energy as well as 53 nutrient and 29 food group intakes using the FFQ. To assess reproducibility, we calculated Spearman correlation coefficients between both FFQs, which showed mostly intermediate-to-high values. Median (range) correlation coefficients and quartile distribution in the same and adjacent categories for energy-adjusted nutrient intakes were 0.55 (0.42-0.84) and 84.7% (76.5%-98.0%) in men and 0.54 (0.35-0.80) and 84.5% (76.1%-94.4%) in women. The respective values for energy-adjusted food group intakes in men and women were also mostly intermediate to high: 0.54 (0.39-0.79) and 83.7% (75.5%-90.8%) in men and 0.57 (0.40-0.83) and 84.5% (77.5%-93.7%) in women. Conclusions: The FFQ developed for the JPHC-NEXT study has reasonable reproducibility. Because this FFQ has also been validated in a previous study, it can be considered a useful dietary assessment tool to examine associations between dietary consumption and lifestyle-related diseases.

    DOI: 10.6133/apjcn.201906_28(2).0019

    Web of Science

    researchmap

  • Low serum 25-hydroxyvitamin D increases cognitive impairment in elderly people. 査読

    Mayumi Sakuma, Kaori Kitamura, Naoto Endo, Takeshi Ikeuchi, Akio Yokoseki, Osamu Onodera, Takeo Oinuma, Takeshi Momotsu, Kenji Sato, Kazutoshi Nakamura, Ichiei Narita

    Journal of bone and mineral metabolism   37 ( 2 )   368 - 375   2019年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It has been reported that many elderly people have low serum levels of 25-hydroxyvitamin D [25(OH)D] and that serum 25(OH)D levels may have a relationship with cognitive function. The aim of this study was to examine the relationship between serum 25(OH)D levels and cognitive function in a Japanese population. This cross-sectional study was performed as a part of the Project in Sado for Total Health (PROST). The PROST study evaluated cognitive state and serum vitamin D level from June 2011 to November 2013 for 740 patients (431 men and 309 women). The Mini-Mental State Examination-Japanese version (MMSE-J) and serum 25(OH)D level measurements were used as assessment tools. Cognitive impairment was defined using MMSE-J ≤ 23 as a cutoff. Multiple logistic regression analyses were performed to calculate the odds ratios (ORs) for low MMSE-J scores. The average subject age was 68.1 years, the average MMSE- J score was 25.9, and the average 25(OH)D level was 24.6 ng/mL. Significant ORs for cognitive impairment were observed for both high age and low serum 25(OH)D. The adjusted OR for the lowest versus highest serum 25(OH)D quartiles was 2.70 (95% confidence interval 1.38-5.28, P = 0.0110). Low serum 25(OH)D levels were independently associated with a higher prevalence of cognitive impairment.

    DOI: 10.1007/s00774-018-0934-z

    PubMed

    researchmap

  • Physical activity modifies the effect of calcium supplements on bone loss in perimenopausal and postmenopausal women: subgroup analysis of a randomized controlled trial. 査読

    Nakamura K, Saito T, Kobayashi R, Oshiki R, Kitamura K, Watanabe Y

    Archives of Osteoporosis   14 ( 1 )   17   2019年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11657-019-0575-4

    PubMed

    researchmap

  • 非標識プロテオミクスによる尿を用いたアルツハイマー病バイオマーカーの可能性

    渡邊 裕美, 平尾 嘉利, 春日 健作, 徳武 孝允, 北村 香織, 池内 健, 山本 格, 中村 和利

    日本衛生学雑誌   74 ( Suppl. )   S147 - S147   2019年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本衛生学会  

    researchmap

  • Molecular network analysis of the urinary proteome of Alzheimer’s disease patients. 査読

    Watanabe Y, Hirao Y, Kasuga K, Tokutake T, Semizu Y, Kitamura K, Ikeuchi T, Nakamura K, Yamamoto T

    Dementia and Geriatric Cognitive Disorders EXTRA   9 ( 9 )   53 - 65   2019年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000496100

    PubMed

    researchmap

  • Epidemiologic profiles of chronic low back and knee pain in middle-aged and elderly Japanese from the Murakami Cohort. 査読

    Takahashi A, Kitamura K, Watanabe Y, Kobayashi R, Saito T, Takachi R, Kabasawa K, Oshiki R, Tsugane S, Iki M, Sasaki A, Yamazaki O, Nakamura K

    Journal of Pain Research   12 ( 11 )   3161 - 3169   2018年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2147/JPR.S184746

    PubMed

    researchmap

  • Menstrual and reproductive factors and risk of vertebral fractures in Japanese women: the Japan Public Health Center-based prospective (JPHC) study 査読

    Shimizu Y, Sawada N, Nakamura K, Watanabe Y, Kitamura K, Iwasaki M, Tsugane S, For the JPHC, Study group

    Osteoporosis International   2018年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    researchmap

  • The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: A study protocol 査読

    Kazutoshi Nakamura, Ribeka Takachi, Kaori Kitamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Yumi Watanabe, Keiko Kabasawa, Akemi Takahashi, Shoichiro Tsugane, Masayuki Iki, Ayako Sasaki, Osamu Yamazaki

    Environmental Health and Preventive Medicine   23 ( 1 )   28   2018年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BioMed Central Ltd.  

    Background: Age-related musculoskeletal diseases are becoming increasingly burdensome in terms of both individual quality of life and medical cost. We intended to establish a large population-based cohort study to determine environmental, lifestyle, and genetic risk factors of musculoskeletal and other age-related diseases, and to clarify the association between vitamin D status and such diseases. Methods: We targeted 34,802 residents aged 40-74 years living in areas of northern Niigata Prefecture, including Sekikawa Village, Awashimaura Village, and Murakami City (Murakami region). The baseline questionnaire survey, conducted between 2011 and 2013, queried respondents on their lifestyle and environmental factors (predictors), and self-reported outcomes. Plasma 25-hydroxyvitamin D (25[OH]D) concentration, an indicator of vitamin D status, was determined with the Liaison® 25OH Vitamin D Total Assay. The primary outcome of this study was osteoporotic fracture
    other outcomes included age-related diseases including knee osteoarthritis, perception of chronic pain, dementia, and long-term care insurance use. Mean ages of men and women were 59.2 (SD = 9.3, N = 6907) and 59.0 (SD = 9.3, N = 7457) years, respectively. From the blood samples provided by 3710 men and 4787 women, mean 25(OH)D concentrations were 56.5 (SD = 18.4) nmol/L (22.6 ng/mL) and 45.4 (SD = 16.5) nmol/L (18.2 ng/mL), respectively. Discussion: Follow-up surveys are planned every 5 years for 15 years, and incident cases of our targeted diseases will be followed at hospitals and clinics in and nearby the cohort area. We anticipate that we will be able to clarify the association between vitamin D status and multiple disease outcomes in a Japanese population.

    DOI: 10.1186/s12199-018-0715-2

    Scopus

    PubMed

    researchmap

  • Effect of monitoring salt concentration of home-prepared dishes and using low-sodium seasonings on sodium intake reduction 査読

    Misako Nakadate, Junko Ishihara, Motoki Iwasaki, Kaori Kitamura, Erika Kato, Junta Tanaka, Kazutoshi Nakamura, Takuma Ishihara, Ayumi Shintani, Ribeka Takachi

    European Journal of Clinical Nutrition   72 ( 10 )   1 - 8   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nature Publishing Group  

    Background/objectives: Objective methods such as the monitoring of salt concentrations in home-prepared dishes may be effective in reducing salt intake. We investigated the effect of monitoring the salt concentration of home-prepared dishes (Monitoring) on salt reduction and change in taste threshold, and the effect of the simultaneous use of low-sodium seasonings (Seasoning) to compare the effect of Monitoring with the conventional method. Subjects/methods: We conducted a double-blind randomized controlled study using a 2 × 2 factorial design with two interventions. A total of 50 participants (40–75 years-old) were recruited among residents of Niigata Prefecture, a high sodium-consuming population in Japan, then randomly allocated to four groups. After excluding participants with incomplete urine collection, change in salt intake was evaluated using 24-hour urinary excretion as a surrogate of intake for 43 participants. Change in taste threshold was evaluated in 48 participants after excluding those with incomplete threshold measurement. Results: The Monitoring intervention group showed a significant decrease in sodium intake (−777 mg/24 h), whereas the decrease in the Seasoning intervention group was not significant (−413 mg/24 h). Sodium intake did not statistically differ between the intervention and control groups (−1011 mg/24 h and −283 mg/24 h for Monitoring and Seasoning, respectively). The changes in taste threshold measurement were very small and did not markedly differ between groups. Conclusions: Monitoring the salt concentration of dishes had a potentially stronger salt-reducing effect than the use of low-sodium seasonings, a conventional method. Confirmation requires additional study with a larger sample size.

    DOI: 10.1038/s41430-017-0053-2

    Scopus

    PubMed

    researchmap

  • Association between dialysis treatment and cognitive decline: A study from the Project in Sado for Total Health (PROST), Japan 査読

    Yumi Watanabe, Kaori Kitamura, Kazutoshi Nakamura, Kazuhiro Sanpei, Minako Wakasugi, Akio Yokoseki, Keiko Kabasawa, Osamu Onodera, Takeshi Ikeuchi, Ryozo Kuwano, Takeshi Momotsu, Ichiei Narita, Naoto Endo

    Geriatrics and Gerontology International   17 ( 10 )   1584 - 1587   2017年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing  

    Aim: Evidence for the association between dialysis treatment and cognitive decline is limited. The present study aimed to determine whether dialysis treatment is associated with cognitive decline in adult outpatients of a general hospital in Japan. Methods: This was a cross-sectional substudy of the Project in Sado for Total Health (PROST). Total Health PROST targeted adult outpatients of a general hospital in Sado City, Niigata, Japan. Among 753 patients (mean age 68.1 ± 11.6 years) analyzed, 66 received dialysis. Cognitive state was evaluated using the Mini-Mental State Examination, and those with a Mini-Mental State Examination score &lt
    24 were considered “cognitively declined.” The prevalence of cognitive decline was compared by odds ratios calculated with multiple logistic regression analysis. Variables included in the analyses were dialysis, age, sex and self-reported histories of hypertension, diabetes, stroke and ischemic heart disease. Results: Of the 66 dialysis patients, 24 (36.4%) showed cognitive decline, whereas 172 (25.0%) of 687 non-dialysis patients showed cognitive decline. The age and sex-adjusted odds ratio for cognitive decline in dialysis patients was 2.57 (95% confidence interval 1.43–4.61), relative to non-dialysis patients. The odds ratio remained significant (odds ratio 2.69, 95% confidence interval 1.49–4.88) even after adjusting for all covariates. Conclusion: The prevalence of cognitive decline was high in dialysis patients relative to non-dialysis patients among outpatients of a general hospital in Japan. Geriatr Gerontol Int 2017
    17: 1584–1587.

    DOI: 10.1111/ggi.12937

    Scopus

    PubMed

    researchmap

  • Weight loss from 20 years of age is associated with cognitive impairment in middle-aged and elderly individuals 査読

    Kaori Kitamura, Yumi Watanabe, Kazutoshi Nakamura, Akemi Takahashi, Ribeka Takachi, Rieko Oshiki, Ryosaku Kobayashi, Toshiko Saito, Shoichiro Tsugane, Ayako Sasaki

    PLOS ONE   12 ( 10 )   e0185960   2017年10月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Background
    Few empirical studies have been conducted to identify modifiable factors that may affect cognitive impairment in Japanese individuals. The present study aimed to clarify whether body mass and lifestyle are associated with cognitive impairment in Japanese middle-aged and elderly individuals.
    Methods
    Subjects were 1814 community-dwelling individuals aged 44-79 years, all of whom were participants of the Murakami Cohort Study baseline survey conducted in 2011-2013. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) in 2014-2016, and cognitive impairment, the outcome measure, was defined as an MMSE score &lt;24. Predictor variables were body mass index (BMI), long-term weight changes from 20 years of age, and lifestyle factors, such as smoking, drinking, and physical activity levels, which were obtained from a self-administered questionnaire in the baseline survey. Covariates were sex, age, education level, and histories of stroke and diabetes. Multiple logistic regression analysis was used to calculate the adjusted odds ratios (ORs).
    Results
    The prevalence of overall cognitive impairment was 6.2%. The adjusted ORs of cognitive impairment in the lowest (&lt;[-4] kg) (OR = 2.70, 95% CI, 1.18-6.20) and second ([-4]-[0] kg) (OR = 2.37, 95% CI, 1.04-5.37) quintiles for long-term weight change were significantly higher than the reference 4th quintile ([+4]-[+7] kg). The adjusted OR in the highest quintile &gt;=[+8] kg) was 2.24 (95% CI, 0.99-5.04). Current BMI was not associated with cognitive impairment.
    Conclusions
    Long-term weight loss is associated with cognitive impairment in Japanese middle-aged and elderly individuals. Because the present study was retrospective in nature, prospective studies should also be conducted for further characterization of this association.

    DOI: 10.1371/journal.pone.0185960

    Web of Science

    PubMed

    researchmap

  • Online version of the self-administered food frequency questionnaire for the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT) protocol: Relative validity, usability, and comparison with a printed questionnaire 査読

    Erika Kato, Ribeka Takachi, Junko Ishihara, Yuri Ishii, Shizuka Sasazuki, Norie Sawada, Motoki Iwasaki, Yurie Shinozawa, Jun Umezawa, Junta Tanaka, Yuta Yokoyama, Kaori Kitamura, Kazutoshi Nakamura, Shoichiro Tsugane

    JOURNAL OF EPIDEMIOLOGY   27 ( 9 )   435 - 446   2017年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Background: Online dietary assessment tools offer advantages over printed questionnaires, such as the automatic and direct data storage of answers, and have the potential to become valuable research methods. We developed an online survey system (web-FFQ) for the existing printed FFQ used in the JPHC-NEXT protocol, the platform of a large-scale genetic cohort study. Here, we examined the validity of ranking individuals according to dietary intake using this web-FFQ and its usability compared with the printed questionnaire (print-FFQ) for combined usage.
    Methods: We included 237 men and women aged 40-74 years from five areas specified in the JPHCNEXT protocol. From 2012 to 2013, participants were asked to provide 12-day weighed food records (12d-WFR) as the reference intake and to respond to the print-and web-FFQs. Spearman's correlation coefficients (CCs) between estimates using the web-FFQ and 12d-WFR were calculated. Crossclassification of intakes was compared with those using the print-FFQ.
    Results: Most participants (83%) answered that completing the web-FFQ was comparable to or easier than completing the printed questionnaire. The median value of CCs across energy and 53 nutrients for men and women was 0.47 (range, 0.10-0.86) and 0.46 (range, 0.16-0.69), respectively. CCs for individual nutrient intakes were closely similar to those based on the print-FFQ, irrespective of response location. Cross-classification by quintile of intake based on two FFQs was reasonably accurate for many nutrients and food groups.
    Conclusion: This online survey system is a reasonably valid measure for ranking individuals by intake for many nutrients, like the printed FFQ. Mixing of two FFQs for exposure assessments in epidemiological studies appears acceptable. (C) 2017 Publishing services by Elsevier B.V. on behalf of The Japan Epidemiological Association.

    DOI: 10.1016/j.je.2016.08.021

    Web of Science

    PubMed

    researchmap

  • Cognitive function is maintained in noninstitutionalized elderly Japanese requiring care with high levels of health-related quality of life 査読

    Kaori Kitamura, Kazutoshi Nakamura, Kimiko Ueno, Tomoko Nishiwaki

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   21 ( 6 )   585 - 590   2016年11月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Health-related quality of life (HRQOL) has been reported to be associated with cognitive function; however, whether or not this relationship involves causality is uncertain. This study aimed to determine whether HRQOL levels are associated with subsequent changes in cognitive function in elderly people requiring care.
    Participants were 74 community-dwelling elderly people utilizing the long-term care service (69 % women) who underwent physical and psychological examinations at baseline and follow-up. The outcome was 2-year changes in Mini-Mental State Examination (a dagger MMSE) score. The potential predictor was HRQOL level assessed by the EuroQol 5 dimension (EQ-5D) score (utility value) at baseline; other variables were body mass index (BMI), Barthel index, grip strength, Geriatric Depression Scale, serum albumin, and serum hemoglobin. Associations between EQ-5D and a dagger MMSE scores were assessed using correlation analysis, regression analysis, and analysis of covariance (ANCOVA).
    Mean age, BMI, and Barthel index at baseline were 81.6 years [standard deviation (SD) 8.2], 21.1 kg/m(2) (SD 4.0), and 79 (SD 20), respectively; the mean a dagger MMSE score was -2.2 (SD 5.1). EQ-5D was significantly correlated with a dagger MMSE (partial r = 0.375, P = 0.0012). The mean a dagger MMSE values of the 1st, 2nd, and 3rd EQ-5D quartiles were -4.2 (adjusted P = 0.0050), -2.6 (adjusted P = 0.0476), and -2.4 (adjusted P = 0.0298), respectively, which were lower than the -0.1 of the reference 4th quartile.
    HRQOL as assessed by EQ-5D is associated with longitudinal cognitive decline in frail elderly people, and cognitive function may be maintained in individuals with high HRQOL levels.

    DOI: 10.1007/s12199-016-0572-9

    Web of Science

    PubMed

    researchmap

  • Rural-urban differences in the prevalence of cognitive impairment in independent community-dwelling elderly residents of Ojiya city, Niigata Prefecture, Japan 査読

    Kazutoshi Nakamura, Kaori Kitamura, Yumi Watanabe, Hiroko Shinoda, Hisami Sato, Toshiyuki Someya

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   21 ( 6 )   422 - 429   2016年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    This study aimed to examine rural-urban differences in the prevalence of cognitive impairment in Japan.
    We targeted 592 residents aged 65 years and older who did not use long-term care insurance services in one rural and two urban areas in Ojiya City, Japan. Of these, 537 (90.7 %) participated in the study. The revised Hasegawa's dementia scale (HDS-R) was used to assess cognitive function, and cognitive impairment was defined as a HDS-R score aecurrency sign20. Lifestyle information was obtained through interviews. The prevalence of cognitive impairment was compared according to the levels of predictor variables by odds ratios (ORs) calculated by a logistic regression analysis.
    Mean age of participants was 75.7 years (SD 7.0). The prevalence of cognitive impairment was 20/239 (8.4 %) in the rural area and 6/298 (2.0 %) in the urban areas, for a total of 26/537 (4.8 %) overall. Men tended to have a higher prevalence of cognitive impairment (P = 0.0628), and age was associated with cognitive impairment (P for trend &lt; 0.0001). The rural area had a significantly higher prevalence of cognitive impairment (age- and sex-adjusted OR = 4.04, 95 % CI: 1.54-10.62) than urban areas. This difference was significant after adjusting for other lifestyle factors.
    The prevalence of cognitive impairment was higher in the rural area relative to urban areas in Ojiya city. This regional difference suggests the existence of potentially modifiable factors other than lifestyle in relation to cognitive impairment.

    DOI: 10.1007/s12199-016-0542-2

    Web of Science

    PubMed

    researchmap

  • Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area 査読

    Yuta Yokoyama, Ribeka Takachi, Junko Ishihara, Yuri Ishii, Shizuka Sasazuki, Norie Sawada, Yurie Shinozawa, Junta Tanaka, Erika Kato, Kaori Kitamura, Kazutoshi Nakamura, Shoichiro Tsugane

    JOURNAL OF EPIDEMIOLOGY   26 ( 8 )   420 - 432   2016年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC  

    Background: Longitudinal epidemiological studies require both the periodic update of intake information via repeated dietary survey and the minimization of subject burden in responding to questionnaires. We developed a 66-item Food Frequency Questionnaire (short-FFQ) for the Japan Public Health Center-based prospective Study for the Next Generation (JPHC-NEXT) follow-up survey using major foods from the FFQ developed for the original JPHC Study. For the JPHC-NEXT baseline survey, we used a larger 172-item FFQ (long-FFQ), which was also derived from the JPHC-FFQ. We compared the validity of ranking individuals by levels of dietary consumption by these FFQs among residents of selected JPHC-NEXT study areas.
    Methods: From 2012 to 2013, 240 men and women aged 40-74 years from five areas in the JPHC-NEXT protocol were asked to respond to the long-FFQ and provide 12-day weighed food records (WFR) as reference; 228 also completed the short-FFQ. Spearman's correlation coefficients (CCs) between estimates from the FFQs and WFR were calculated and corrected for intra-individual variation of the WFR.
    Results: Median CC values for energy and 53 nutrients for the short-FFQ for men and women were 0.46 and 0.44, respectively. Respective values for the long-FFQ were 0.50 and 0.43. Compared with the long-FFQ, cross-classification into exact plus adjacent quintiles with the short-FFQ ranged from 68% to 91% in men and 58% to 85% in women.
    Conclusions: Similar to the long-FFQ, the short-FFQ provided reasonably valid measures for ranking middle-aged and elderly Japanese for many nutrients and food groups. The short-FFQ can be used in follow-up surveys in prospective cohort studies aimed at updating diet rank information.

    DOI: 10.2188/jea.JE20150064

    Web of Science

    PubMed

    researchmap

  • Association between Dietary Intake and Bone Mineral Density in Japanese Postmenopausal Women: The Yokogoshi Cohort Study 査読

    Harumi Hirata, Kaori Kitamura, Toshiko Saito, Ryosaku Kobayashi, Masanori Iwasaki, Akihiro Yoshihara, Yumi Watanabe, Rieko Oshiki, Tomoko Nishiwaki, Kazutoshi Nakamura

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   239 ( 2 )   95 - 101   2016年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TOHOKU UNIV MEDICAL PRESS  

    Diet and food intake play an important role in the development of osteoporosis. However, apart from calcium and vitamin D, how nutrients affect bone status is not fully understood. The purpose of this study was to determine cross-sectional and longitudinal associations between dietary intake and bone mineral density (BMD) in Japanese postmenopausal women. This 5-year cohort study included 600 community dwelling women aged 55-74 years at baseline in 2005. Information on demographics, nutrition, and lifestyle was obtained through interviews, and nutritional and dietary intake was assessed using a validated food frequency questionnaire. BMD measurements were performed by dual energy X-ray absorptiometry. In 2010, 498 women underwent follow-up BMD examinations. Multiple linear regression analysis was performed to determine associations of predictor variables with BMD, adjusting for confounders. In cross-sectional analyses, coffee or black tea consumption was positively associated with lumbar spine (P = 0.004) and total hip (P = 0.003) BMD, and alcohol intake was positively associated with femoral neck (P = 0.005) and total hip (P = 0.001) BMD. In longitudinal analyses, vitamin K (P = 0.028) and natto (fermented soybeans) (P = 0.023) were positively associated with lumbar spine BMD, and meat or meat product consumption was inversely associated with total hip (P = 0.047) BMD. In conclusion, dietary factors other than calcium and vitamin D intake are predictors of bone mass and bone loss in Japanese postmenopausal women. In particular, natto intake is recommended for preventing postmenopausal bone loss on the basis of current evidence.

    DOI: 10.1620/tjem.239.95

    Web of Science

    PubMed

    researchmap

  • 地域在住中高年者の認知機能と教育歴の関連 査読

    北村 香織, 渡邊 裕美, 中村 和利

    日本老年医学会雑誌   53 ( Suppl. )   151 - 151   2016年5月

     詳細を見る

    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

    researchmap

  • Modifiable Factors Associated with Cognitive Impairment in 1,143 Japanese Outpatients: The Project in Sado for Total Health (PROST) 査読

    Kaori Kitamura, Yumi Watanabe, Kazutoshi Nakamura, Kazuhiro Sanpei, Minako Wakasugi, Akio Yokoseki, Osamu Onodera, Takeshi Ikeuchi, Ryozo Kuwano, Takeshi Momotsu, Ichiei Narita, Naoto Endo

    Dementia and Geriatric Cognitive Disorders Extra   6 ( 2 )   341 - 349   2016年

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:S. Karger AG  

    Background/Aims: Evidence on modifiable factors associated with cognitive impairment in Japanese patients is scarce. This study aimed to determine modifiable factors for cognitive impairment in a Japanese hospital-based population. Methods: Subjects of this cross-sectional study were 1,143 patients of Sado General Hospital (Niigata, Japan) registered in the Project in Sado for Total Health (PROST) between June 2008 and September 2014. We assessed disease history, body mass index (BMI), leisure time physical activity, walking time, smoking and drinking habits, and consumption of vegetables, fruits, and green tea as predictors, with cognitive impairment defined by the Mini-Mental State Examination (score &lt
    24) as an outcome. Multiple logistic regression analysis was performed to calculate odds ratios (ORs) for cognitive impairment. Results: The mean subject age was 68.9 years, and the prevalence of cognitive impairment was 21.5%. Multivariate analysis revealed that age (p &lt
    0.001), low BMI (&lt
    21.1
    OR 1.39, 95% CI 1.12-1.72), a history of stroke (p = 0.003), a history of myocardial infarction (p = 0.038), low fruit consumption (p for trend = 0.012), and low green tea consumption (p for trend = 0.032) were independently associated with a higher prevalence of cognitive impairment. Conclusions: Modifiable factors, such as low BMI, low fruit consumption, and low green tea consumption, are associated with cognitive impairment. Longitudinal studies will be needed to confirm these findings.

    DOI: 10.1159/000447963

    Scopus

    researchmap

  • Elevated C-Reactive Protein is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST) 査読

    Yumi Watanabe, Kaori Kitamura, Kazutoshi Nakamura, Kazuhiro Sanpei, Minako Wakasugi, Akio Yokoseki, Osamu Onodera, Takeshi Ikeuchi, Ryozo Kuwano, Takeshi Momotsu, Ichiei Narita, Naoto Endo

    Dementia and Geriatric Cognitive Disorders Extra   6 ( 1 )   10 - 19   2016年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:S. Karger AG  

    Background/Aims: We aimed to determine whether the concentration of serum C-reactive protein (CRP) is associated with cognitive function in an adult Japanese population. Methods: Participants of this cross-sectional study were from a subgroup of the Project in Sado for Total Health (PROST
    n = 454
    mean age, 70.5 years). The cognitive state was evaluated using the Mini-Mental State Examination (MMSE), and those with an MMSE score &lt
    24 were considered 'cognitively declined'. Concentrations of serum high-sensitivity CRP were measured. Multiple logistic regression analysis was used to calculate odds ratios (ORs) for cognitive decline, adjusting for the covariates of age, sex, BMI, disease history, and APOE allele. Results: Of the 454 participants, 94 (20.7%) were cognitively declined. Relative to the lowest (first) quartile of CRP concentration, adjusted ORs were 1.29 (95% CI 0.61-2.75) for the second, 1.78 (95% CI 0.82-3.86) for the third, and 3.05 (95% CI 1.45-6.42) for the highest (fourth) quartiles (p for trend = 0.018). When data were stratified by sex, the association between CRP concentration and cognitive decline was observed only in women. Conclusion: Our findings suggest an association between higher CRP concentration and lower cognitive function. Chronic inflammation may affect cognitive function in adults, in particular women.

    DOI: 10.1159/000442585

    Scopus

    PubMed

    researchmap

  • Property damage and long-term psychological distress after the 2004 Niigata-Chuetsu earthquake in Ojiya, Japan: a community-based study 査読

    Kazutoshi Nakamura, Kaori Kitamura, Yoshiharu Kim, Toshiyuki Someya

    JOURNAL OF PUBLIC HEALTH   37 ( 3 )   398 - 405   2015年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Background This study aimed to assess psychological distress (PD) in earthquake-stricken communities with regard to the extent of property damage for 3 years following the 2004 Niigata-Chuetsu earthquake in Japan.
    Methods Subjects were participants of health check examinations in a community near the epicentre, and included 7097 residents (a parts per thousand yen18 years) in 2005, 6586 in 2006 and 6698 in 2007. Interviews assessed PD symptoms and lifestyles. The Kessler Psychological Distress Scale (K10) was used, with scores a parts per thousand yen20 considered as PD. The 137 subdistricts were divided into quartiles according to the proportion of half-completely destroyed houses at cut-offs of 18.9, 30.5 and 66.7%.
    Results The PD prevalence was 17.0% in 2005, 13.2% in 2006 and 11.8% in 2007. In 2005, the more and most heavily damaged groups had significantly higher PD prevalence (OR = 1.5 and 1.4, respectively) than that of the least damaged group with a dose-dependent relationship (P = 0.0005). This association was weaker in 2006 (P = 0.0413) and in 2007 (P = 0.1816).
    Conclusions Psychological distress prevalence was high in highly damaged areas, and the prevalence difference between areas with high versus low damage decreases with time. Extensive mental health care in communities with substantial damage should be expected to last 2 years after an earthquake.

    DOI: 10.1093/pubmed/fdu052

    Web of Science

    PubMed

    researchmap

  • Impact of demographic, environmental, and lifestyle factors on vitamin D sufficiency in 9084 Japanese adults 査読

    K. Nakamura, K. Kitamura, R. Takachi, T. Saito, R. Kobayashi, R. Oshiki, Y. Watanabe, S. Tsugane, A. Sasaki, O. Yamazaki

    BONE   74   10 - 17   2015年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Background: Little is known about correlates of vitamin D status in Asian populations. In this study, we established the prevalence of vitamin D sufficiency in the Murakami region (latitude N38 degrees 13') in Niigata, Japan, and examined demographic, environmental, and lifestyle factors that might be associated with vitamin D sufficiency, with the aim of clarifying the relative contributions of previously described determinants of vitamin D status as well as identifying new determinants in this Japanese population.
    Methods: This study involved a cross-sectional analysis of baseline data obtained from a cohort study conducted in 2011-2013. Participants were 9084 individuals aged between 40 and 74 years who provided blood samples for the determination of plasma 25-hydroxyvitamin D [25(OH)D] concentrations. Lifestyle information was obtained from 8498 participants, with some missing values regarding different lifestyle factors. Multiple logistic regression analysis was used to obtain odds ratios for vitamin D sufficiency, which was defined as a plasma 25(OH)D concentration &gt;= 75 nmol/L.
    Results: The prevalence of vitamin D sufficiency (i.e., plasma 25(OH)D concentration &gt;= 75 nmol/L) was 9.1%, and significant associations were observed with male gender (P &lt;0.0001; OR = 2.37, 95% CI: 1.84-3.05), older age (P for trend &lt;0.0001), lower BMI (P for trend &lt;0.0001), higher METs score (P for trend = 0.0138), higher vitamin D intake (P for trend = 0.0467), summer season (P for trend &lt;0.0001), longer duration outdoors (P for trend = 0.0026), no sunscreen use (P = 0.0135; OR = 1.40, 95% CI: 1.07-1.82), higher salmon consumption (P for trend &lt;0.0001), higher alcohol consumption (P for trend &lt;0.0001), and lower coffee consumption (P for trend = 0.0025). Unlike other populations previously reported, vitamin D sufficiency was associated with older age.
    Conclusions: The prevalence of vitamin D sufficiency (i.e., 25[OH]D &gt;= 75 nmol/L) was low (9.1%) in this Japanese population. A number of demographic, environmental, and lifestyle factors are associated with vitamin D sufficiency, and thus lifestyle modification may present an opportunity to achieve vitamin D sufficiency. (c) 2015 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.bone.2014.12.064

    Web of Science

    researchmap

  • Prolonged occupational activity and 6-year changes in postural sway in elderly women 査読

    K. Nakamura, K. Kitamura, R. Oshiki, R. Kobayashi, T. Saito, T. Nishiwaki

    JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS   15 ( 1 )   78 - 82   2015年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JMNI  

    Objectives: Prolonged occupational work such as farm work has been reported to adversely affect mobility in elderly women. The purpose of this study was to investigate possible relationships between prolonged occupational work and 6-year changes in postural sway in elderly women. Methods: Subjects were 392 women aged &gt;= 69 years who participated in a 6-year follow-up examination of the Muramatsu Cohort Study. Handgrip strength and postural sway, measured as gravity-center velocity (cm/s), were evaluated at baseline and 6-year follow-up. Interviews were conducted to determine the time spent on moderate occupational activity (3-5 metabolic equivalents) such as farm work. Activity levels were defined as: 1, no-activity; 2, "short" (&gt;0, &lt;= 17.75 h/wk); and 3, "long" (&gt;= 17.75 h/wk). Results: At baseline, mean values for age, handgrip strength, and postural sway were 73.3 years (SD 3.7), 20.3 kg (SD 4.1), and 2.0 cm/s (SD 0.8), respectively, and 32.5% of participants engaged in occupational activity. The change in postural sway was significantly greater in the long-activity group (median, 35.0 h/wk) than the no-activity group (0.56 vs. 0.27 cm/s, P=0.021). Conclusions: Prolonged occupational work may be detrimental to the control of body balance. Accordingly, elderly individuals are not recommended to engage in prolonged occupational activity.

    Web of Science

    researchmap

  • Physical activity and 10-year incidence of self-reported vertebral fractures in Japanese women: The Japan Public Health Center-based Prospective Study 査読

    K. Nakamura, K. Kitamura, M. Inoue, N. Sawada, S. Tsugane

    OSTEOPOROSIS INTERNATIONAL   25 ( 11 )   2565 - 2571   2014年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER LONDON LTD  

    This study assessed the effects of physical activity on a 10-year incidence of self-reported vertebral fractures in adult women of a large Japanese cohort. Medium levels of strenuous activity and long-duration sedentary activity were associated with a lower incidence of vertebral fractures; association patterns appear to be different from hip fractures.
    Physical activity helps prevent hip fracture, but little is known about the longitudinal association between physical activity and vertebral fractures. The purpose of this study was to evaluate the effects of physical activity on the 10-year incidence of symptomatic vertebral fractures using data from the Japan Public Health Center-based Prospective Study.
    Baseline studies were conducted in 1993-1994, and the follow-up study was conducted 10 years later. We analyzed 23,757 women aged 40-69 years. At baseline, physical activity was assessed as a predictor by using a questionnaire. Subjects were asked to report vertebral fractures that occurred during the 10-year follow-up period. Relative risks (RRs) adjusted for confounders were estimated by multiple logistic regression analysis.
    The 10-year cumulative incidence of vertebral fractures was 0.67 %. Those who engaged in strenuous physical activity of &lt; 1 h/day had a significantly lower incidence of vertebral fractures than those who did not engage in such activity (RR = 0.52, 95 % CI 0.28-0.97), while those engaged in such activity a parts per thousand yen1 h/day did not (RR = 0.82, 95 % CI 0.58-1.14). Long-duration sedentary activity was associated with a low incidence of vertebral fractures (P for trend = 0.0002), but the frequencies of sports activities and metabolic equivalents were not (P for trend = 0.0729 and 0.4341, respectively).
    Strenuous activity and sedentary activity are associated with the incidence of vertebral fractures, although the association may not be linear. The pattern of association between physical activity and vertebral fractures appears to be different from that of hip fractures.

    DOI: 10.1007/s00198-014-2770-x

    Web of Science

    researchmap

  • Psychological Recovery 5 Years After the 2004 Niigata-Chuetsu Earthquake in Yamakoshi, Japan 査読

    Nakamura K, Kitamura K, Someya T

    J Epidemiol   24 ( 2 )   125 - 131   2014年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: The 2004 Niigata-Chuetsu earthquake of Japan caused considerable damage. We assessed long-term changes in psychological distress among earthquake victims during the period 5 years after the earthquake.Methods: The participants were people aged 18 years or older living in Yamakoshi, a community in Niigata Prefecture near the epicenter. A self-administered questionnaire survey was conducted annually for 5 consecutive years after the earthquake. Response rates were 1316/1841 (71.5%) in 2005, 667/1381 (48.3%) in 2006, 753/1451 (51.9%) in 2007, 541/1243 (43.5%) in 2008, and 814/1158 (70.3%) in 2009. The questionnaire asked about demographic characteristics, including sex, age, employment status, social network, and psychological status. Psychological distress was assessed using the 12-item General Health Questionnaire and was defined as a total score of 4 or higher.Results: The overall prevalence of psychological distress decreased (P &lt; 0.0001) gradually from 2005 (51.0%) to 2008 (30.1%) but tended to increase from 2008 to 2009 (P = 0.1590). Subgroup analyses showed that prevalence did not decrease over the 5-year study period among participants with poor social contact (

    DOI: 10.2188/jea.JE20130097

    Web of Science

    PubMed

    researchmap

  • Association between body mass index and mortality among institutionalized elderly adults in Japan 査読

    Akemi Nakazawa, Kazutoshi Nakamura, Kaori Kitamura, Yoshiaki Yoshizawa

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   18 ( 6 )   502 - 506   2013年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The purpose of this study is to assess the association between body mass index (BMI) and mortality among nursing home residents in Japan.
    A one-year prospective cohort study was conducted with 8,510 elderly individuals across 140 nursing homes. Baseline measurements included age, sex, height, weight, BMI, activities of daily living (ADL) (Barthel Index), and degree of dementia. Information regarding dates of discharge and mortality were also obtained to calculate person-years. Cox's proportional hazards model was used to estimate hazard ratios.
    Mean age and BMI were 84.3 [standard deviation (SD) 8.1] years and 20.6 (SD 3.8) kg/m(2), respectively. Hazard ratios of mortality adjusted for sex, age, ADL, degree of dementia, and type of home were 2.4 [95 % confidence interval (CI): 1.9-3.1] for the 1st quintile of BMI (&lt; 17.3 kg/m(2)), 1.7 (95 % CI: 1.3-2.3) for the 2nd quintile (17.3-19.2 kg/m(2)), 1.5 (95 % CI: 1.2-2.0) for the 3rd quintile (19.3-21.1 kg/m(2)), and 1.2 (95 % CI: 0.9-1.6) for the 4th quintile (21.2-23.5 kg/m(2)) (P for trend &lt; 0.001), compared with the reference 5th quintile (23.6a parts per thousand currency sign kg/m(2)).
    There was a clear inverse dose-dependent relationship between BMI and mortality. Future studies should be conducted to determine the effects of nutritional intervention on mortality in institutionalized elderly adults.

    DOI: 10.1007/s12199-013-0351-9

    Web of Science

    researchmap

  • High serum 25-hydroxyvitamin D levels do not retard postmenopausal bone loss in Japanese women: the Yokogoshi study. 査読 国際誌

    Kaori Kitamura, Kazutoshi Nakamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

    Archives of osteoporosis   8 ( 1-2 )   153 - 153   2013年

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER LONDON LTD  

    UNLABELLED: We conducted a cohort study exploring an association between serum 25-hydroxyvitamin D (serum 25(OH)D) and parathyroid hormone (PTH) levels and 5-year changes in bone mineral density (BMD) in 482 postmenopausal women. High serum 25(OH)D levels do not retard postmenopausal bone loss within the lumbar spine or femoral neck, and high PTH levels potentially increase hip bone loss. PURPOSE: The aim of this study was to explore an association between serum 25(OH)D levels and 5-year changes in BMD in postmenopausal women. METHODS: This 5-year cohort study included 482 women between 55 and 74 years of age who lived in a community in Japan. Medical examinations were conducted in 2005 and 2010. Data were obtained on baseline serum 25(OH)D and intact parathyroid hormone (iPTH) levels. Outcomes of this study were 5-year changes in BMDs of the lumbar spine and femoral neck. Covariates included years since menopause, body mass index (BMI), lifestyle factors, and weight change. Changes in BMDs among quartiles of serum 25(OH)D were compared with analysis of covariance. RESULTS: The mean age of subjects was 63.1 years, and mean serum 25(OH)D levels were 56.0 nmol/L. Age and decrease in weight were significantly associated with decreases in BMDs of both the lumbar spine (P for trend < 0.001 and =0.002, respectively) and femoral neck (P for trend = 0.026 and <0.001, respectively); low BMI was associated with a decrease in lumbar spine BMD (P for trend < 0.001). No significant associations were found between serum 25(OH)D levels and changes in BMDs. High serum iPTH levels were associated with a greater decrease in femoral neck BMD (P for trend = 0.026). CONCLUSIONS: High serum 25(OH)D levels do not retard postmenopausal bone loss within the lumbar spine or femoral neck, and high PTH levels potentially increase hip bone loss.

    DOI: 10.1007/s11657-013-0153-0

    Web of Science

    PubMed

    researchmap

  • Association Between Activities of Daily Living and Mortality Among Institutionalized Elderly Adults in Japan 査読

    Akemi Nakazawa, Kazutoshi Nakamura, Kaori Kitamura, Yoshiaki Yoshizawa

    JOURNAL OF EPIDEMIOLOGY   22 ( 6 )   501 - 507   2012年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC  

    Background: We assessed the association between activities of daily living (ADL) and mortality among nursing home residents in Japan.
    Methods: This I-year prospective cohort study investigated 8902 elderly adults in 140 nursing homes. Baseline measurements included age, sex, height, weight, body mass index (BMI), ADL, and dementia level. ADL levels were obtained by caregivers, using the Barthel Index (BI), after which total BI scores were calculated (higher scores indicate less dependence). Information on dates of discharge and mortality was also obtained to calculate person-years. The Cox proportional hazards model was used to estimate hazard ratios (HRs).
    Results: Mean age was 84.3 years, and mean total BI score was 38.5. The HRs of mortality adjusted for sex, age, BM I, and type of nursing home were 7.6 (95% CI: 3.3-17.8) for those with a BI score of 0 (totally dependent), 3.9 (1.7-9.0) for those with a score of 1 to 10, 3.5 (1.4-8.7) for those with a score of 11 to 40, 2.7 (1.4-5.1) for those with a score of 41 to 70, and 1.3 (0.7-2.4) for those with a score of 71 to 99 (P for trend &lt;0.001), as compared with those with a score of 100. Multivariate analysis revealed that BI, sex, age, and BMI were significantly associated with mortality rate.
    Conclusions: There was a clear inverse association between ADL level and mortality. In conjunction with other risk factors, ADL level might effectively predict short-term mortality in institutionalized elderly adults.

    DOI: 10.2188/jea.JE20110153

    Web of Science

    PubMed

    researchmap

  • Effect of Low-Dose Calcium Supplements on Bone Loss in Perimenopausal and Postmenopausal Asian Women: A Randomized Controlled Trial 査読

    Kazutoshi Nakamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Kaori Kitamura, Mari Oyama, Sachiko Narisawa, Mitsue Nashimoto, Shunsuke Takahashi, Ribeka Takachi

    JOURNAL OF BONE AND MINERAL RESEARCH   27 ( 11 )   2264 - 2270   2012年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Current standard-dose calcium supplements (eg, 1000 mg/d) may increase the risk for cardiovascular events. Effectiveness of lower-dose supplements in preventing bone loss should thus be considered. This study aimed to assess whether calcium supplements of 500 or 250 mg/d effectively prevent bone loss in perimenopausal and postmenopausal Japanese women. We recruited 450 Japanese women between 50 and 75 years of age. They were randomly assigned to receive 500 mg of calcium (as calcium carbonate), 250 mg of calcium, or placebo daily. Medical examinations conducted three times over a 2-year follow-up period assessed bone mineral density (BMD) of the lumbar spine and femoral neck. One-factor repeated measures ANOVA was used for statistical tests. Subgroup analyses were also conducted. Average total daily calcium intake at baseline for the 418 subjects who underwent follow-up examinations was 493 mg/d. Intention-to-treat analysis showed less dramatic decreases in spinal BMD for the 500-mg/d calcium supplement group compared to the placebo group (1.2% difference over 2 years, p = 0.027). Per-protocol analysis (&gt;= 80% compliance) revealed that spinal BMD for the 500 mg/d and 250-mg/d calcium supplement groups decreased less than the placebo group (1.6%, p = 0.010 and 1.0%, p = 0.078, respectively), and that femoral neck BMD for the 500-mg/d calcium supplement group decreased less relative to the placebo group (1.0%, p = 0.077). A low-dose calcium supplement of 500 mg/d can effectively slow lumbar spine bone loss in perimenopausal and postmenopausal women with habitually low calcium intake, but its effect on the femoral neck is less certain. Calcium supplementation dosage should thus be reassessed. (Clinical Trials Registry number: UMIN000001176). (C) 2012 American Society for Bone and Mineral Research.

    DOI: 10.1002/jbmr.1676

    Web of Science

    PubMed

    researchmap

  • Effect of low-dose calcium supplements on bone loss in perimenopausal and postmenopausal Asian women: A randomized controlled trial 査読

    Kazutoshi Nakamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Kaori Kitamura, Mari Oyama, Sachiko Narisawa, Mitsue Nashimoto, Shunsuke Takahashi, Ribeka Takachi

    Journal of Bone and Mineral Research   27 ( 11 )   2264 - 2270   2012年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Current standard-dose calcium supplements (eg, 1000 mg/d) may increase the risk for cardiovascular events. Effectiveness of lower-dose supplements in preventing bone loss should thus be considered. This study aimed to assess whether calcium supplements of 500 or 250 mg/d effectively prevent bone loss in perimenopausal and postmenopausal Japanese women. We recruited 450 Japanese women between 50 and 75 years of age. They were randomly assigned to receive 500 mg of calcium (as calcium carbonate), 250 mg of calcium, or placebo daily. Medical examinations conducted three times over a 2-year follow-up period assessed bone mineral density (BMD) of the lumbar spine and femoral neck. One-factor repeated measures ANOVA was used for statistical tests. Subgroup analyses were also conducted. Average total daily calcium intake at baseline for the 418 subjects who underwent follow-up examinations was 493 mg/d. Intention-to-treat analysis showed less dramatic decreases in spinal BMD for the 500-mg/d calcium supplement group compared to the placebo group (1.2% difference over 2 years, p = 0.027). Per-protocol analysis (≤80% compliance) revealed that spinal BMD for the 500-mg/d and 250-mg/d calcium supplement groups decreased less than the placebo group (1.6%, p = 0.010 and 1.0%, p = 0.078, respectively), and that femoral neck BMD for the 500-mg/d calcium supplement group decreased less relative to the placebo group (1.0%, p = 0.077). A low-dose calcium supplement of 500 mg/d can effectively slow lumbar spine bone loss in perimenopausal and postmenopausal women with habitually low calcium intake, but its effect on the femoral neck is less certain. Calcium supplementation dosage should thus be reassessed. (Clinical Trials Registry number: UMIN000001176). © 2012 American Society for Bone and Mineral Research.

    DOI: 10.1002/jbmr.1676

    Scopus

    PubMed

    researchmap

  • Determination of whether the association between serum albumin and activities of daily living in frail elderly people is causal 査読

    Kaori Kitamura, Kazutoshi Nakamura, Tomoko Nishiwaki, Kimiko Ueno, Akemi Nakazawa, Mariko Hasegawa

    Environmental Health and Preventive Medicine   17 ( 2 )   164 - 168   2012年3月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objectives Serum albumin and activities of daily living (ADL) are associated with each other, but whether the association is causal is not known. The purpose of this study was to determine whether a causal association exists between serum albumin and ADL levels. Methods The subjects were 116 frail elderly individuals (34 men and 82 women
    mean age 83.0 years). Demographic characteristics, serum albumin, ADL, and handgrip strength were measured at a baseline examination and at a follow-up examination 2 years later. Levels of ADL were assessed with the Barthel Index. Pearson's correlation coefficients were calculated for serum albumin, ADL, and handgrip strength for baseline values and for their 2-year changes (Δ). Results At baseline, the mean serum albumin concentration was 4.0 g/dL and the total score of the Barthel Index (baseline Barthel Index) was 71.1. The baseline serum albumin level correlated significantly with the baseline Barthel Index (r = 0.287) and baseline handgrip strength (r = 0.315), but not with Δ Barthel Index (r = 0.096) or Δ handgrip strength (r = - 0.058). The Δ serum albumin correlated significantly with Δ Barthel Index (r = 0.296), but not with Δ handgrip strength (r = 0.182), baseline Barthel Index (r = - 0.044), or baseline handgrip strength (r = 0.047). Conclusions This 2-year cohort study has demonstrated that a decrease in serum albumin levels is associated with a decrease in ADL levels. A third factor may play a role in adversely affecting both serum albumin and ADL levels in frail elderly people. © The Japanese Society for Hygiene 2011.

    DOI: 10.1007/s12199-011-0233-y

    Scopus

    PubMed

    researchmap

  • Physical activity and 5-year changes in physical performance tests and bone mineral density in postmenopausal women: The Yokogoshi Study 査読 国際誌

    Kaori Kitamura, Kazutoshi Nakamura, Ryosaku Kobayashi, Rieko Oshiki, Toshiko Saito, Mari Oyama, Shunsuke Takahashi, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

    MATURITAS   70 ( 1 )   80 - 84   2011年9月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: The effect of physical activity on musculoskeletal health in older adults is not completely understood. The aim of this study was to determine the relationship between physical activity and 5-year changes in physical performance tests and bone mineral density (BMD) in postmenopausal women.
    Study design: The design was a 5-year cohort study.
    Main outcome measures: Subjects were 507 women (55-74 years old) living in a rural community in Japan. Physical activity assessed included housework, farm work, and moderate leisure-time physical activity within the previous week. Measurements at baseline included handgrip strength, walking time (timed "Up & Go" test) and BMD of the femoral neck and vertebrae. Five-year changes in these measures (outcome variables) were compared among groups with different levels of physical activity by analysis of covariance.
    Results: Women who did not do housework performed worse in changes in handgrip strength (difference = 2.22 kg, P = 0.0201) and worse in changes in the walking time (difference = 0.54 s, P = 0.0072) than those who did housework alone. Women who spent at least 9 h per week (median = 24) doing farm work performed better in changes in handgrip strength (difference = 0.28 kg, P= 0.0334), but worse in changes in the walking time (difference = 0.66 s, P&lt;0.0001) than those who did not do farm work. However, leisure-time activity was not associated with changes in any outcome variable, and none of the physical activities predicted BMD changes.
    Conclusions: Engaging in housework and farm work are determinants of physical function in postmenopausal women, which may help them maintain independence in daily living. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.maturitas.2011.06.014

    Web of Science

    PubMed

    researchmap

  • Low Body Mass Index and Low Serum Albumin Are Predictive Factors for Short-Term Mortality in Elderly Japanese Requiring Home Care 査読

    Kaori Kitamura, Kazutoshi Nakamura, Tomoko Nishiwaki, Kimiko Ueno, Mariko Hasegawa

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   221 ( 1 )   29 - 34   2010年5月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TOHOKU UNIV MEDICAL PRESS  

    Japan has a rapidly growing elderly population requiring care. This study aimed to clarify risk factors for two-year mortality in such people. Subjects included 205 community-dwelling elderly people, who were approved for care in the 2003 Yamato Study, an epidemiologic study of individuals utilizing the long-term care service system. Demographic characteristics, Barthel index (measuring activities of daily living), grip strength, thigh muscle volume, psychological evaluation, and blood values including hemoglobin, serum albumin, and serum 25-hydroxyvitamin D levels were investigated at baseline. The average age of subjects was 83.6 (S.D., 8.0) years. Of the 205 subjects, 42 died during the follow-up period. Bivariate analysis showed that older age (p = 0.0015), lower weight (p = 0.0087), lower body mass index (BMI) (p = 0.0001), lower Barthel index (p = 0.0017), lower hemoglobin (p = 0.0180), and lower serum albumin (p = 0.0001) were associated with mortality, but that sex was not (p = 0.1248). Stepwise multiple logistic regression analysis showed that BMI &lt; 17.1 kg/m(2) (adjusted OR = 4.0, p = 0.0007), age &gt;= 90 years (adjusted OR = 3.3, p = 0.0033), and lower serum albumin levels (adjusted OR = 0.86, p = 0.0007) were independently associated with mortality. We conclude that low BMI and low serum albumin are strong predictors of 2-year mortality in frail elderly individuals, and that nutritional risk should appropriately be evaluated for elderly people requiring home care.

    DOI: 10.1620/tjem.221.29

    Web of Science

    PubMed

    researchmap

  • 骨粗鬆症とQOL (看護に活かすQOLの視点) -- (疾患別QOL向上に向けた実践) 招待

    丸山 敬子, 北村 香織, 高橋 榮明, 山本 智章, 中川 マユミ

    臨床看護   33 ( 12 )   1824 - 1828   2007年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:へるす出版  

    CiNii Article

    researchmap

▶ 全件表示

書籍等出版物

  • よくわかる自殺対策―多分野連携と現場力で「いのち」を守る

    本橋 豊( 担当: 共著)

    ぎょうせい  2015年4月  ( ISBN:4324099367

     詳細を見る

    総ページ数:293   記述言語:日本語 著書種別:学術書

    ASIN

    researchmap

MISC

  • 新潟大学のコホート研究・臨床疫学研究の進捗状況と今後の展望 村上コホート研究

    中村 和利, 北村 香織, 渡邊 裕美

    新潟医学会雑誌   132 ( 4 )   127 - 130   2018年4月

     詳細を見る

    記述言語:日本語   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)   出版者・発行元:新潟医学会  

    私たちは、健康寿命延伸とビタミンDの加齢性疾患予防効果の解明を目的として、加齢性運動器疾患、認知症、その他の疾患のリスク要因や予防要因を包括的に解明する地域住民コホート研究を2011年に新潟県村上保健所管内で開始した。エンドポイントは、死亡と疾患罹患率であり、対象疾患は、骨粗鬆症性骨折、変形性膝関節症、認知症、慢性疼痛、その他である。健康調査票によるベースライン調査に同意した参加者(n=14,364)の平均年齢は、男性59.2歳(SD=9.3、n=6,907)、女性59.0歳(SD=9.3、n=7,457)であった。また、血液検体のある参加者(n=8,497)の平均年齢は、男性56.5歳(SD=18.4、n=3,710)、女性45.4歳(SD=16.5、n=4,787)であった。調査票による5年後フォローアップ調査を2016〜2017年に行い(回収率61%)、疾患追跡を順調に進めている。(著者抄録)

    researchmap

  • ロコモティブシンドロームの現在 展望と問題点 ロコモ・フレイル予防 地域での取り組み

    佐久間 真由美, 青木 可奈, 北村 香織, 遠藤 直人

    日本サルコペニア・フレイル学会雑誌   1 ( 2 )   100 - 100   2017年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本サルコペニア・フレイル学会  

    researchmap

  • 家庭調味モニタリングの介入研究ベースラインにおける地域別基本特性の検討(1)ナトリウム・高塩分食品摂取

    三浦咲, 中舘美佐子, 石原淳子, 石原淳子, 岩崎基, 中村和利, 北村香織, 加藤恵梨香, 横山悠太, 横山悠太, 田中純太, 柏木友紀穂, 松木祐実, 高地リベカ, 高地リベカ

    日本疫学会学術総会講演集(Web)   27th   147 (WEB ONLY)   2017年1月

     詳細を見る

    記述言語:日本語  

    J-GLOBAL

    researchmap

  • 家庭調味モニタリングの介入研究ベースラインにおける地域別基本特性の検討(2)食習慣・食嗜好

    中舘美佐子, 石原淳子, 石原淳子, 岩崎基, 中村和利, 北村香織, 加藤恵梨香, 横山悠太, 横山悠太, 田中純太, 柏木友紀穂, 松木祐美, 三浦咲, 高地リベカ, 高地リベカ

    日本疫学会学術総会講演集(Web)   27th   148 (WEB ONLY)   2017年1月

     詳細を見る

    記述言語:日本語  

    J-GLOBAL

    researchmap

  • 地域総合病院通院患者における透析療法と認知機能スケールとの関連 PROST

    渡邊 裕美, 北村 香織, 若杉 三奈子, 横関 明男, 三瓶 一弘, 小野寺 理, 池内 健, 百都 健, 成田 一衛, 遠藤 直人

    Dementia Japan   30 ( 4 )   550 - 550   2016年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本認知症学会  

    researchmap

  • 地域総合病院通院患者における透析療法と認知機能スケールとの関連 PROST

    渡邊 裕美, 北村 香織, 若杉 三奈子, 横関 明男, 三瓶 一弘, 小野寺 理, 池内 健, 百都 健, 成田 一衛, 遠藤 直人

    Dementia Japan   30 ( 4 )   550 - 550   2016年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本認知症学会  

    researchmap

  • 新潟県中越地震被災地における住民の心の健康の推移 招待

    中村 和利, 北村 香織

    自殺予防と危機介入   36 ( 2 )   8 - 12   2016年3月

     詳細を見る

    記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

    researchmap

  • 味付けの好み・食行動と24時間尿中ナトリウム排泄量(5回/年)との関連

    山岸万里菜, 高地リベカ, 高地リベカ, 高地リベカ, 石原淳子, 石原淳子, 石井有里, 石井有里, 篠澤友里江, 横山悠太, 横山悠太, 北村香織, 野田愛, 野田愛, 三代泉, 貢英彦, 澤田典絵, 島津太一, 中村和利, 田中純太, 磯博康, 笹月静, 津金昌一郎

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   147   2016年1月

     詳細を見る

    記述言語:日本語  

    J-GLOBAL

    researchmap

  • 地域総合病院通院患者の血清高感度C反応性蛋白(CRP)と認知機能スケールとの関連 PROST

    渡邊 裕美, 北村 香織, 中村 和利, 横関 明男, 三瓶 一弘, 小野寺 理, 池内 健, 百都 健, 成田 一衛, 遠藤 直人

    Dementia Japan   29 ( 3 )   368 - 368   2015年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本認知症学会  

    researchmap

  • THE MURAKAMI COHORT STUDY FOR THE PREVENTION OF MUSCULOSKELETAL DISEASES WITH VITAMIN D IN JAPAN

    K. Nakamura, K. Kitamura, R. Takachi, T. Saito, R. Kobayashi, R. Oshiki, Y. Watanabe

    OSTEOPOROSIS INTERNATIONAL   26   S227 - S228   2015年2月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER LONDON LTD  

    Web of Science

    researchmap

  • SERUM 25-HYDROXYVITAMIN D LEVELS IN A POPULATION-BASED COHORT IN JAPAN: MURAKAMI COHORT STUDY

    K. Nakamura, K. Kitamura, T. Saito, R. Kobayashi, R. Oshiki, R. Takachi, A. Sasaki, O. Yamazaki

    OSTEOPOROSIS INTERNATIONAL   24   S558 - S558   2013年12月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER LONDON LTD  

    Web of Science

    researchmap

  • 村上コホート研究について

    中村 和利, 髙地 リベカ, 北村 香織, 斎藤 トシ子, 小林 量作, 押木 利英子, 佐々木 綾子, 山﨑 理

    新潟県医師会報   740 ( 740 )   2 - 5   2011年11月

     詳細を見る

    記述言語:日本語   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)   出版者・発行元:新潟県医師会  

    researchmap

  • モジュールを使用した専門職間連携教育の取り組み 脊椎圧迫骨折患者の予防・治療と在宅支援

    佐久間 真由美, 丸山 敬子, 星野 惠美子, 北村 香織, 高橋 榮明

    運動療法と物理療法   22 ( 2 )   246 - 246   2011年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本運動器科学会  

    researchmap

▶ 全件表示

講演・口頭発表等

  • 短時間の午睡は高齢者の認知機能低下を予防する:5年間の縦断的研究

    北村香織, 渡邊裕美, 中村和利, 林直美, 高野千香子, 佐藤久美

    日本臨床疫学会 第3回年次学術大会  2019年9月 

     詳細を見る

    記述言語:日本語   会議種別:ポスター発表  

    researchmap

  • 非標識プロテオミクスによる尿を用いたアルツハイマー病バイオマーカーの可能性

    渡邊 裕美, 平尾 嘉利, 春日 健作, 徳武 孝允, 北村 香織, 池内 健, 山本 格, 中村 和利

    日本衛生学雑誌  2019年2月 

     詳細を見る

    記述言語:日本語  

    researchmap

  • ロコモティブシンドロームの現在 展望と問題点 ロコモ・フレイル予防 地域での取り組み

    佐久間 真由美, 青木 可奈, 北村 香織, 遠藤 直人

    日本サルコペニア・フレイル学会雑誌  2017年10月 

     詳細を見る

    記述言語:日本語  

    researchmap

  • 地域総合病院通院患者における透析療法と認知機能スケールとの関連 PROST

    渡邊 裕美, 北村 香織, 若杉 三奈子, 横関 明男, 三瓶 一弘, 小野寺 理, 池内 健, 百都 健, 成田 一衛, 遠藤 直人

    Dementia Japan  2016年10月 

     詳細を見る

    記述言語:日本語  

    researchmap

  • 地域在住中高年者の認知機能と教育歴の関連

    北村 香織, 渡邊 裕美, 中村 和利

    日本老年医学会雑誌  2016年5月 

     詳細を見る

    記述言語:日本語   会議種別:ポスター発表  

    researchmap

  • 地域総合病院通院患者の血清高感度C反応性蛋白(CRP)と認知機能スケールとの関連 PROST

    渡邊 裕美, 北村 香織, 中村 和利, 横関 明男, 三瓶 一弘, 小野寺 理, 池内 健, 百都 健, 成田 一衛, 遠藤 直人

    Dementia Japan  2015年9月 

     詳細を見る

    記述言語:日本語  

    researchmap

  • 加齢性運動器疾患の分子疫学コホート研究(村上鮭で元気プロジェクト)

    中村 和利, 高地 リベカ, 北村 香織, 斎藤 トシ子, 小林 量作, 押木 利英子, 佐々木 綾子, 山崎 理, 伊木 雅之

    日本公衆衛生学会総会抄録集  2013年10月 

     詳細を見る

    記述言語:日本語  

    researchmap

  • 地域住民における血中25-hydroxyvitamin Dレベル 村上コホート研究

    中村 和利, 北村 香織, 斎藤 トシ子, 小林 量作, 押木 利英子, 高地 リベカ, 佐々木 綾子, 山崎 理

    Osteoporosis Japan  2013年9月 

     詳細を見る

    記述言語:日本語  

    researchmap

  • モジュールを使用した専門職間連携教育の取り組み 脊椎圧迫骨折患者の予防・治療と在宅支援

    佐久間 真由美, 丸山 敬子, 星野 惠美子, 北村 香織, 高橋 榮明

    運動療法と物理療法  2011年6月 

     詳細を見る

    記述言語:日本語  

    researchmap

  • 在宅看護学実習における地区踏査の教育効果と指導のあり方

    丸山 敬子, 北村 香織

    日本看護科学学会学術集会講演集  2010年12月 

     詳細を見る

    記述言語:日本語  

    researchmap

▶ 全件表示

共同研究・競争的資金等の研究

  • 大規模コホートにおける認知症および認知機能低下の変容可能な予防・リスク要因の解明

    研究課題/領域番号:20K10526  2020年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    北村 香織, 中村 和利

      詳細を見る

    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    researchmap

  • 縦断研究による、尿プロテオミクスによる認知症予測バイオマーカー探索

    研究課題/領域番号:20K10427  2020年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    渡邊 裕美, 平尾 嘉利, 北村 香織

      詳細を見る

    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    researchmap

  • 地域在住高齢者の認知機能低下予防プログラムの開発

    2018年 - 2019年

    公益財団法人木村看護教育振興財団  受託研究(一般受託研究) 

    北村香織

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

    researchmap

  • 尿メタボロミクス解析による認知症予測バイオマーカーの網羅的探索

    研究課題/領域番号:17K19799  2017年6月 - 2019年3月

    日本学術振興会  科学研究費助成事業 挑戦的研究(萌芽)  挑戦的研究(萌芽)

    中村 和利, 渡邊 裕美, 池内 健, 山本 格, 蒲澤 佳子, 北村 香織

      詳細を見る

    配分額:6370000円 ( 直接経費:4900000円 、 間接経費:1470000円 )

    本研究は、網羅的な低分子代謝産物の解析(メタボロミクス解析)により、アルツハイマー病(AD)患者に特有の尿中(水溶性)低分子バイオマーカーを同定することを目的とし、AD病患者群9例と対照群9例の尿検体に見出されるイオン性代謝産物の特性を予測モデルと妥当性モデルの両方で比較した。予測モデルで増加、減少した代謝産物がそれぞれ2個、7個、妥当性モデルで有意に増加、減少した代謝産物がそれぞれ3個、6個同定された。両モデルに共通して有意な減少を示した代謝産物はGlycerol-3-phosphateであった。Glycerol-3-phosphateは新たなADのバイオマーカーである可能性が示唆された。

    researchmap

  • 大規模コホートによる認知症の環境リスク要因および遺伝要因との相互作用の解明

    研究課題/領域番号:17K09198  2017年4月 - 2020年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    北村 香織, 中村 和利

      詳細を見る

    資金種別:競争的資金

    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

    本研究は分子疫学コホート研究(村上コホート研究、対象地域:村上市、関川村、粟島浦村)の枠組みにおいて、体質を考慮した日本人の認知症の変容可能な要因を解明するコホート研究であり、認知症の一次予防におけるポピュレーションアプローチ及びハイリスクアプローチに資することを目的とする。
    調査は、医療機関での認知症診断(診療情報調査)及び要介護情報に基づく新規認知症(要介護認知症)をエンドポイントとして収集している。①認知症の環境リスク要因および遺伝要因を検討するために、ベースライン調査における、基本属性、生活習慣要因のデータや、バイオマーカーが既存情報として利用可能であり、現時点で収集された新規症例について中間解析を行った。②また、ベースライン保存血液検体のあるサブグループにおいて認知症の強力な感受性遺伝子であるアポリポプロテインE遺伝子の遺伝子多型を解析することにより、nested case-control studyの手法を用いて環境要因と遺伝要因との相互作用を検討する。現時点で収集された症例群と対照群の検体について遺伝子解析を進めた。

    researchmap

  • 加齢性運動器疾患の大規模分子疫学コホート研究5年後フォローアップ

    研究課題/領域番号:15H04782  2015年4月 - 2019年3月

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    中村 和利, 伊木 雅之, 渡邊 裕美, 北村 香織, 高地 リベカ, 小林 量作

      詳細を見る

    配分額:15860000円 ( 直接経費:12200000円 、 間接経費:3660000円 )

    本研究により、2011年に開始した加齢性運動器疾患の大規模コホート研究の5年後フォローアップを完了した。具体的には、40から74歳の13,816人を対象として生活習慣等のアンケート調査を行い、8,487(61.4%)より回答を得た。また、追跡期間中に死亡373人、骨粗鬆症性骨折284人、変形性膝関節症429人が観察された。これらの資料より、死亡、骨粗鬆症性骨折、変形性膝関節症、慢性疼痛のリスク要因を解析することができた。また、5年間の生活習慣等の情報を比較することにより、ベースラインにおける曝露情報の再評価を行うことができた。

    researchmap

  • 大規模コホートによる認知症の環境・生活習慣リスク要因の解明

    研究課題/領域番号:26860436  2014年4月 - 2017年3月

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    北村 香織

      詳細を見る

    資金種別:競争的資金

    配分額:3770000円 ( 直接経費:2900000円 、 間接経費:870000円 )

    本研究は、村上コホート研究の枠組みにおいて、認知症発症を新たなエンドポイントとして把握し、認知症の環境・生活習慣に関連したリスク要因を解明することを目的とした。コホート追跡調査により認知症新規症例120例を得た。さらにサブコートとして1,814人にMMSEによる認知機能検査を行い、112例の認知機能障害を得た。認知機能障害に関連する人口統計学的および生活習慣関連のリスク要因を解析した。

    researchmap

  • 慢性疼痛の大規模疫学調査研究

    2011年4月 - 2013年3月

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    北村香織

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

    researchmap

  • 慢性疼痛の大規模疫学調査研究

    研究課題/領域番号:23790708  2011年 - 2012年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    北村 香織

      詳細を見る

    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

    本研究は、日本人中高年者14,194人を対象に慢性疼痛の有病率を明らかにすることを目的とした。自記式の調査票による調査の結果、全体の39%の者がなんらかの慢性疼痛を持ち、そのうちの1割は強い痛みであることが明らかになった。慢性疼痛の有病率は加齢とともに上昇し、男性より女性で高いことも示された。部位別では、腰・臀部、膝関節、肩関節の疼痛の有病率が高く、筋骨格系の基礎疾患の関与が示唆された。

    researchmap

▶ 全件表示

 

担当経験のある授業科目

  • 環境医学

    2021年
    -
    現在
    機関名:新潟大学

  • 病気と遺伝学

    2021年
    -
    現在
    機関名:新潟大学

  • 疫学

    2021年
    -
    現在
    機関名:新潟大学