2022/12/10 更新

写真a

ヨシダ クニヒコ
吉田 邦彦
YOSHIDA Kunihiko
所属
医歯学総合病院 魚沼地域医療教育センター 特任講師
職名
特任講師
外部リンク

学位

  • 学士(医学) ( 2005年3月   新潟大学 )

研究分野

  • ライフサイエンス / 産婦人科学

経歴

  • 新潟大学   医歯学総合病院 魚沼地域医療教育センター   特任講師

    2020年4月 - 現在

  • 新潟大学   医歯学総合病院 総合周産期母子医療センター   助教

    2015年6月 - 2018年3月

  • 新潟大学   医歯学総合病院 産科婦人科   特任助教

    2014年7月 - 2015年5月

  • 新潟大学   医歯学総合病院 産科婦人科   特任助教

    2012年4月 - 2013年9月

学歴

  • 新潟大学   医学部   医学科

    1998年4月 - 2005年3月

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    国名: 日本国

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論文

  • Possible involvement of the E-cadherin gene in genetic susceptibility to endometriosis. 国際誌

    Kunihiko Yoshida, Kosuke Yoshihara, Sosuke Adachi, Kazufumi Haino, Koji Nishino, Masayuki Yamaguchi, Nobumichi Nishikawa, Katsunori Kashima, Tetsuro Yahata, Hideaki Masuzaki, Hidetaka Katabuchi, Kenichiro Ikuma, Hiroshi Suginami, Kenichi Tanaka

    Human reproduction (Oxford, England)   27 ( 6 )   1685 - 9   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Endometriotic cells display invasive characteristics, despite their benign histological appearance. Recently, the epithelial-mesenchymal transition, in which epithelial cells acquire mesenchymal and migratory properties, has attracted attention as a mechanism of tumor invasion. We aimed to investigate the association between endometriosis and polymorphisms of the E-cadherin gene, a central player in the epithelial-mesenchymal transition, in Japanese women. METHODS: Twelve single-nucleotide polymorphisms (SNPs) in the E-cadherin gene were identified by real-time polymerase chain reaction using a TaqMan assay in 511 women with endometriosis (the majority in Stages III and IV) and 498 healthy controls. RESULTS: Allele frequency analysis indicated that there was a marginally higher frequency of the rs4783689 C allele in women with endometriosis compared with controls (corrected P = 0.007; odds ratio = 1.37; 95% confidence interval, 1.14-1.64). No significant associations with endometriosis were found for the other 11 SNPs. CONCLUSIONS: Although this study was limited by sample size, the E-cadherin gene polymorphism rs4783689 was marginally associated with endometriosis in the Japanese population, suggesting that E-cadherin might be involved in genetic susceptibility to endometriosis.

    DOI: 10.1093/humrep/des080

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  • Microdissection testicular sperm extraction in five Japanese patients with non-mosaic Klinefelter's syndrome.

    Makoto Chihara, Kanna Ogi, Tatsuya Ishiguro, Kunihiko Yoshida, Chikako Godo, Koichi Takakuwa, Takayuki Enomoto

    Reproductive medicine and biology   17 ( 2 )   209 - 216   2018年4月

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    記述言語:英語  

    Cases: Microdissection testicular sperm extraction (micro-TESE) was performed on five Japanese men with non-mosaic Klinefelter's syndrome (KS) and non-obstructive azoospermia in the authors' department. Here is reported the operative results and partner's clinical course for two cases where spermatozoa could be acquired. Also encountered was a man with non-mosaic KS with the partial deletion of azoospermia factor (AZF)b. Because this is rare, it is reported in detail in the context of the previous literature. This case series describes the first experience of micro-TESE by gynecologists in the current department. Outcome: The egg collection date was adjusted to the micro-TESE day by using the modified ultra-long method. Intracytoplasmic sperm injection (ICSI) was implemented for two men whose spermatozoa were acquired by micro-TESE, with these progressing to the blastocyst stage. Subsequently, one case conceived after the transfer of fresh embryos and a healthy baby was delivered. However, spermatozoa could not be retrieved from the man with non-mosaic KS who was harboring the partial deletion of AZFb. Conclusion: These findings suggest that ovulation induction by using the modified ultra-long method with micro-TESE and ICSI on the same day represents an effective treatment option for men with non-mosaic KS. As there are cases where AZF deletion is recognized among patients with non-mosaic KS, screening before micro-TESE is strongly recommended.

    DOI: 10.1002/rmb2.12092

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  • Case with pyoderma gangrenosum abruptly emerging around the wound of cesarean section for placenta previa with placenta accrete. 国際誌

    Taro Nonaka, Kunihiko Yoshida, Masayuki Yamaguchi, Atsuko Aizawa, Hiroshi Fujiwara, Takayuki Enomoto, Koichi Takakuwa

    The journal of obstetrics and gynaecology research   42 ( 9 )   1190 - 3   2016年9月

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    記述言語:英語  

    A 39-year-old woman underwent emergency cesarean section (CS) due to placenta previa totalis with massive bleeding. Two major problems emerged in this patient after CS was carried out. One was partial retention of the placenta due to placenta accreta. Another major and more serious problem was pyoderma gangrenosum (PG) widely appearing at the skin of the abdomen around the CS wound. Conservative treatment was performed for the retained placenta, and it had completely disappeared by 76 days after the CS. The diagnosis of PG was promptly made in consultation with a plastic surgeon and a dermatologist when a wide ulcer emerged around the CS wound, and high-dose prednisolone was administered as treatment. At 90 days following the CS, near-complete epithelialization was achieved. This extremely rare case reflects the importance of rapid diagnosis and treatment of PG.

    DOI: 10.1111/jog.13033

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  • Successful management of severe intrahepatic cholestasis of pregnancy: report of a first Japanese case. 国際誌

    Kenya Kamimura, Hiroyuki Abe, Naomi Kamimura, Masayuki Yamaguchi, Maiko Mamizu, Kanna Ogi, Yoshifumi Takahashi, Ken-Ichi Mizuno, Hiroteru Kamimura, Yuji Kobayashi, Manabu Takeuchi, Kunihiko Yoshida, Kyoko Yamada, Takayuki Enomoto, Koichi Takakuwa, Minoru Nomoto, Miki Obata, Yoshinori Katsuragi, Yukio Mishima, Ryo Kominami, Tomoteru Kamimura, Yutaka Aoyagi

    BMC gastroenterology   14   160 - 160   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is a cholestasis condition caused by elevated levels of serum bile acids that mainly occurs in the third trimester of pregnancy. Maternal symptoms include pruritus; elevation of transaminases, biliary enzymes, and bilirubin levels; and abnormal liver function tests. Fetal symptoms include spontaneous preterm labor, fetal distress, and intrauterine death. It is more prevalent in the Caucasians and is rarely found in Asian countries, including Japan. The etiology of ICP has been reported as involving various factors such as, environmental factors, hormone balance, and genetic components. The genetic factors include single-nucleotide polymorphisms (SNPs) in the genes of canalicular transporters, including ABCB4 and ABCB11. It has also been reported that the combination of these SNPs induces severe cholestasis and liver dysfunction. CASE PRESENTATION: Here, we report for the first time a 24-year Japanese case of severe ICP diagnosed by typical symptoms, serum biochemical analysis, and treated with the administration of ursodeoxycholic acid which improved cholestasis and liver injury and prevented fetal death. The sequence analysis showed SNPs reported their association with ICP in the ABCB11 (rs2287622, V444A) and ABCB4 (rs1202283, N168N) loci. CONCLUSION: The risk of ICP has been reported to be population-specific, and it is rare in the Japanese population. Our case was successfully treated with ursodeoxycholic acid and the genetic sequence analysis has supported the diagnosis. Because genetic variation in ABCB4 and ABCB11 has also been reported in the Japanese population, we need to be aware of potential ICP cases in pregnant Japanese women although further studies are necessary.

    DOI: 10.1186/1471-230X-14-160

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MISC

  • A case-control study of risk factors for placenta previa accreta

    Masayuki Yamaguchi, Taeko Hyuga, Kunihiko Yoshida, Mina Itsukaichi, Taro Nonaka, Kazufumi Haino, Takayuki Enomoto, Koichi Takakuwa

    JOURNAL OF REPRODUCTIVE IMMUNOLOGY   118   122 - 123   2016年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.jri.2016.10.041

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  • Analysis of pregnant women with inflammatory bowel disease in our hospital

    Kunihiko Yoshida, Taeko Hyuga, Kentaro Sugino, Manako Yamaguchi, Tomoko Tamura, Taro Nonaka, Kazufumi Haino, Masayuki Yamaguchi, Koichi Takakuwa, Takayuki Enomoto

    JOURNAL OF REPRODUCTIVE IMMUNOLOGY   118   122 - 122   2016年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.jri.2016.10.040

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  • A CASE REPORT OF PLACENTA PREVIA PERCRETA WITH MASSIVE HEMORRHAGE IN EARLY PREGNANCY

    Masayuki Yamaguchi, Kunihiko Yoshida, Kazufumi Haino, Koichi Takakuwa, Takayuki Enomoto

    PLACENTA   34 ( 10 )   A14 - A14   2013年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:W B SAUNDERS CO LTD  

    DOI: 10.1016/j.placenta.2013.07.053

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