Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Wide-necked aneurysms can be treated by double stenting in an X- or Y-configuration or by a double waffle-cone technique. However, some aneurysms remain untreatable. OBSERVATIONS: The rupture of a complex wide-necked anterior communicating artery (AcomA) aneurysm that caused acute subarachnoid hemorrhage (SAH) was treated successfully using double stents with an opposite L-configuration as an alternative to the X-stent technique. The aneurysm involved both A1-A2 junctions in the aneurysm neck with acutely oriented A2 segments of the anterior cerebral artery bilaterally. It was densely packed and completely obliterated angiographically with preserved blood flow by implanting each stent in the ipsilateral A1-A2 bilaterally. Blood flow from the left A1 to the right A2 was confirmed through the AcomA on injection of the left internal carotid artery immediately after the procedure without critical infarction in the subthalamic area. Although the AcomA was not demonstrated by injection of the left internal carotid artery on angiography at 3 months or 1 year later, no cerebral infarction was seen on magnetic resonance images at the final hospital visit. LESSONS: Opposite L-configuration double stenting was used successfully as rescue stent-assisted coiling for a rupture of a complex wide-necked AcomA aneurysm in a patient with acute SAH.

DOI： 10.3171/CASE22165

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: De novo bleb formation at the aneurysm neck after coil embolization of unruptured intracranial aneurysms is a rarely observed type of recurrence. The aim of this study was to elucidate the clinical characteristics of recurrent aneurysms in the long-term period. METHODS: Between January 2002 and December 2015, 290 unruptured intracranial aneurysms were treated with coil embolization at our institution. Patients who underwent retreatment due to aneurysm recurrence were divided into 2 patterns of recanalization: de novo bleb formation at the neck of a coiled sac (type DNV) and an enlarged residual cavity without de novo bleb formation (type non-DNV). RESULTS: Twenty-seven patients with aneurysms (9.3%) underwent retreatment (type DNV, 7; type non-DNV, 20). The initial aneurysm size of type DNV aneurysms was significantly smaller than that of type non-DNV (6.1 ± 2.2 mm vs. 10.1 ± 3.6 mm; P < 0.01), and time to retreatment in type DNV was significantly longer than that in type non-DNV (9.4 ± 5.3 years vs. 2.0 ± 2.0 years; P < 0.01). Two type DNV basilar artery (BA) aneurysms ruptured after a few years; however, the other type DNV aneurysms, including 4 anterior circulation aneurysms (including the internal carotid artery), were observed to grow gradually without rupture for >10 years until retreatment. CONCLUSIONS: De novo bleb formation at the neck of a coiled sac emerges with insidious growth during long-term follow-up. Constant caution should be exercised, even in cases of small- and medium-sized anterior circulation aneurysms. A risk of rupture risk may be anticipated, especially in BA lesions.

DOI： 10.1016/j.wneu.2022.02.092

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: Conventional time-of-flight (TOF) magnetic resonance angiography (MRA) failed to depict clear visualization of coiled cerebral aneurysms with PulseRider due to metal-induced susceptibility artifacts. Our aim was to overcome the metal artifact using a novel imaging technique of non-contrast-enhanced ultrashort echo-time magnetic resonance angiography (UTE-MRA). MATERIALS AND METHODS: Five unruptured intracranial aneurysms were treated using PulseRider and the patients underwent silent MRA (UTE-MRA). The images were compared with TOF-MRA and digital subtraction angiography (DSA). RESULTS: Silent MRA can visualize the residual cavity of the coiled aneurysms, which was not well visualized and rather defective when using TOF-MRA. While a segment of the proximal marker composed of stainless steel was poorly visualized, the other parts of the parent artery and the arteries of bifurcation, including the aneurysmal neck, were clearly visualized, equivalent to that of DSA. CONCLUSIONS: UTE-MRA achieves better visualization of cerebral aneurysms after PulseRider treatment than TOF-MRA.

DOI： 10.1007/s11604-022-01276-z

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

The selective provocative test (SPT) under local anesthesia aids in protecting against ischemic complications during endovascular treatment. However, the use of this test under general anesthesia is not well described. Herein, we present a case of a 51-year-old man with a ruptured fusiform aneurysm in the middle cerebral artery M4 segment, which was thought to possibly supply the motor cortex. Internal trapping of the affected vessel and aneurysm by endovascular intervention was successfully performed after SPT using transcranial motor evoked potential (MEP) monitoring under general anesthesia. Transcranial MEP is suitable for neurological assessment during SPT under general anesthesia.

DOI： 10.1007/s00701-021-05001-z

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: Although many studies have analyzed risk factors for contralateral progression in unilateral moyamoya disease, they have not been fully elucidated. The aim of this study was to examine whether genetic factors as well as nongenetic factors are involved in the contralateral progression. METHODS: The authors performed a multicenter cohort study in which 93 cases with unilateral moyamoya disease were retrospectively reviewed. The demographic features, RNF213 R4810K mutation, lifestyle factors such as smoking and drinking, past medical history, and angiographic findings were analyzed. A Cox proportional hazards model was used to find risk factors for contralateral progression. RESULTS: Contralateral progression was observed in 24.7% of cases during a mean follow-up period of 72.2 months. Clinical characteristics were not significantly different between 63 patients with the R4810K mutation and those without it. Cox regression analysis showed that the R4810K mutation (hazard ratio [HR] 4.64, p = 0.044), childhood onset (HR 7.21, p < 0.001), male sex (HR 2.85, p = 0.023), and daily alcohol drinking (HR 4.25, p = 0.034) were independent risk factors for contralateral progression. CONCLUSIONS: These results indicate that both genetic and nongenetic factors are associated with contralateral progression of unilateral moyamoya disease. The findings would serve to help us better understand the pathophysiology of moyamoya disease and to manage patients more appropriately.

DOI： 10.3171/2021.3.JNS203913

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: Delayed bleeding of unruptured intracranial aneurysms (UIAs) after coil embolization is rare; this study aimed to analyze the occurrence of delayed bleeding of UIAs after coil embolization. METHODS: We retrospectively analyzed patients with UIAs after coil embolization between January 2002 and December 2018 and assessed the features of UIAs with delayed bleeding after coil embolization. RESULTS: Analysis included 307 patients with 335 UIAs. Mean follow-up was 7.1 ± 4.9 years, and total follow-up was 2365 aneurysm-years. There were 271 (80.9%) aneurysms located in the anterior circulation and 64 (19.1%) aneurysms located in the posterior circulation. Significant differences were observed between the 2 groups in terms of maximum size of the aneurysm (P < 0.01), width of the aneurysm neck (P < 0.01), and number of retreatment cases (P < 0.01). During the follow-up period, delayed bleeding occurred in 4 aneurysms (annual bleeding rate of 0.17%); all were located in the posterior circulation. The original size was not relatively large (mean 8.6 ± 2.4 mm). All aneurysms bled within 5 years (mean 35 ± 9.6 months) after the initial treatment. Two were de novo aneurysms that developed adjacent to the coiled aneurysms and were not detected on follow-up magnetic resonance angiography. CONCLUSIONS: Cautious follow-up of UIAs with digital subtraction angiography is important, articularly within the first 5 years after the procedure. If there are changes in the anatomic outcomes, short-term reassessment or additional treatment should be actively considered, particularly for aneurysms in the posterior circulation.

DOI： 10.1016/j.wneu.2021.02.061

PubMed

researchmap

Language：English  

BACKGROUND: Choroidal collaterals are a risk factor for hemorrhagic stroke, even in the nonhemorrhagic hemisphere, among patients with moyamoya disease (MMD). Peripheral choroidal aneurysms rupture in fragile collaterals; however, the development and natural course of these aneurysms remain elusive. OBSERVATIONS: A 51-year-old woman, who had experienced a right cerebral hemorrhage 3 years earlier, presented with asymptomatic minor bleeding from a left lateral choroidal artery aneurysm in a predeveloped choroidal anastomosis. Although the aneurysm spontaneously thrombosed within 2 months, the choroidal collaterals persisted. After bypass surgery, the choroidal anastomosis regressed, and neither a de novo aneurysm nor a hemorrhagic stroke occurred. A 75-year-old woman with MMD, who had experienced a left frontal infarction 6 years earlier, experienced recurrent right intraventricular hemorrhage from a ruptured lateral choroidal artery aneurysm that developed in the choroidal anastomosis. The aneurysm spontaneously regressed 3 days after the rebleeding with no recurrence over the following 7 years. LESSONS: Choroidal artery aneurysms may develop in the choroidal anastomosis and rupture in the nonsurgical or contralateral hemispheres. Patients with MMD who have a history of hemorrhagic or ischemic stroke and impaired cerebral blood flow require careful observation. Although aneurysms may rapidly regress spontaneously, bypass surgery can stabilize hemodynamic stress and prevent further hemorrhage.

DOI： 10.3171/CASE2110

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

Unilateral oculomotor nerve palsy, often caused by aneurysmal compression, is one of the decisive findings for confirming the site of a ruptured aneurysm. However, arterial compression can also cause unilateral oculomotor nerve palsy. Here, we present the case of a 59-year-old woman with a ruptured right internal carotid-posterior communicating artery aneurysm accompanied by contralateral oculomotor nerve palsy. The nerve was found to be compressed by the posterior cerebral artery and was isolated from the ruptured aneurysm. When confirming a ruptured aneurysm based on the evidence of unilateral oculomotor palsy, the arteries surrounding the nerve must be thoroughly assessed.

DOI： 10.1007/s00701-020-04633-x

PubMed

researchmap

Language：English  

BACKGROUND: Bow hunter's syndrome or stroke (BHS) is characterized by rotational vertebrobasilar insufficiency elicited by rotation of the neck. It is caused by dynamic and reversible occlusion of the vertebral artery (VA). Reversible symptoms of rotational vertebrobasilar insufficiency are described as bow hunter's syndrome, although brain infarction is rarely reported as bow hunter's stroke. OBSERVATIONS: A 70-year-old man experienced repeated cerebellar infarctions three times in the posterior inferior cerebellar artery (PICA) distribution of the nondominant right VA connecting the basilar artery. The onset of symptoms indicating cerebellar infarcts and the patient's head position changes were unrelated. Dynamic digital angiography (DA) revealed that the nondominant right VA was occluded by an osteophyte from the C4 vertebral body, and the right PICA branches were shown to be passing through the distal right VA from the left VA. These findings were observed when the patient's head was tilted to the right. An arterio-arterial embolic mechanism was suggested as the cause of repeated cerebellar infarctions. LESSONS: Transient nondominant VA occlusion has been rarely reported as a cause of BHS when the head is tilted. To confirm the diagnosis of BHS, additional head tilt is recommended when performing dynamic DA in patients with a cervical osteophyte.

DOI： 10.3171/CASE2061

PubMed

researchmap

Language：English  

Background: Perianeurysmal edema (PAE) has been suggested as an indicator of potential aneurysm rupture; however, the hemodynamic features of these aneurysms are still unknown. A computational fluid dynamic (CFD) analysis was performed to evaluate the hemodynamic features of a very rare case of a ruptured middle cerebral artery (MCA) aneurysm with PAE. Case Description: A 65-year-old woman presented with disturbed consciousness. A subarachnoid hemorrhage due to an azygos anterior cerebral artery (ACA) aneurysm rupture was suspected. An unruptured MCA aneurysm with PAE was identified in the left temporal lobe. Although the ACA aneurysm was clipped to prevent re-bleeding, the MCA aneurysm subsequently ruptured 6 days later. Clipping of the MCA aneurysm was performed, and hemosiderin deposits suggestive of sentinel bleeding were found on the surface of the aneurysm dome. CFD analysis revealed unstable hemodynamic stress at the expanded bleb area after rupture, localized to the rupture site. Moreover, this analysis revealed flow impingement with pressure elevation and low wall shear stress, which indicated increased inflammation and aneurysm wall thinning that likely led to rupture. Conclusion: Hemosiderin deposits at the aneurysm wall and PAE indicates leakage from a cerebral aneurysm. Hemodynamic stress at the aneurysm may promote an inflammatory response and lead to wall weakening accompanied by PAE. Based on our findings, we recommend that surgical intervention should be considered as the first line of treatment for such aneurysms to prevent rupture.

DOI： 10.25259/SNI_780_2020

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: We aimed to evaluate the safety and feasibility of the distal transradial approach (DTRA) as a novel technique for cerebral angiography based on our institutional initial experience. METHODS: We retrospectively analyzed our institutional database of consecutive diagnostic cerebral angiographies performed with DTRA from December 2018 to August 2019. Patient demographics and clinical and procedural data were recorded. RESULTS: In total, 51 diagnostic cerebral angiographies in 51 patients (age, 15-83 years; mean age, 59.4 years, SD 13.5; 35 (69%) females) were performed or attempted with DTRA. Ultrasound evaluation showed that the mean inner distal radial artery diameter was significantly smaller than the mean inner forearm radial artery diameter (2.19 mm vs. 2.56 mm, P < 0.001). Cannulation via the distal radial artery was successful in 47 (92%) procedures. In the four procedures that failed, operators converted to the ipsilateral transradial approach without repositioning or redraping. Selective catheterization of the intended vessel was achieved in 64 (91%) of 70 vessels. In the remaining six, operators achieved the objective of the examination with angiography injecting from proximal and conversion to another approach was not required. One patient experienced temporary numbness around the puncture site after the procedure. No radial artery occlusion was identified in the patients who underwent ultrasound evaluation. CONCLUSION: Our results demonstrate that DTRA could become a standard approach for diagnostic cerebral angiography owing to the low complication rate and the high cannulation success rate.

DOI： 10.1177/1591019920925709

PubMed

researchmap

Language：Japanese   Publishing type：Research paper (scientific journal)  

We report the case of a 76-year-old woman who presented with recurrent episodes of complex visual hallucinations in her right visual field without an anopsia. The electroencephalogram showed sharp transients in the left parietotemporal region with phase reversals at T5 and P3. FLAIR MRI revealed hyperintense lesions in the left temporo-occipital lobe, located mainly in the left inferior temporal lobe. Cerebral angiography revealed an arteriovenous shunt from the left occipital artery to the left transverse sinus with cortical venous reflux. The complex visual hallucinations were resolved after transarterial embolization. We therefore hypothesize that this patient's complex visual hallucinations were caused by epileptic seizures or changes in cortical blood flow caused by the cortical venous reflux from the arteriovenous fistula. In general, epileptic hallucinations expand into the bilateral visual field. We reveal that in rare cases, complex visual hallucinations can also be limited to the unilateral visual field without an anopsia. Additionally, we reveal that a dural arteriovenous fistula can cause visual hallucinations without hemianopia.

DOI： 10.5692/clinicalneurol.60.cn-001371

PubMed

researchmap

Language：Japanese   Publishing type：Research paper (scientific journal)  

Although blunt carotid artery injury is known as an important cause of ischemic stroke, the role of the endovascular treatment for acute ischemic stroke related to blunt carotid injuries remains unclear. We report the case of a patient with acute ischemic stroke secondary to blunt carotid artery injury who was treated with endovascular revascularization. A 46-year-old man suffered from sudden left-sided hemiparesis a day after a strike from a Japanese fencing staff on his right neck. 3D-CT angiography revealed tandem internal carotid artery occlusions of the cervical and C1 portions. We performed endovascular revascularization with carotid artery stenting and direct aspiration of the thrombus and achieved complete recanalization. The patient recovered almost completely. We conclude that endovascular revascularization should not be withheld from patients with acute ischemic stroke related to blunt carotid injury.

DOI： 10.11477/mf.1436204223

PubMed

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

【目的】Anterior condylar confluence(ACC)近傍硬膜動静脈瘻に対し,顔面静脈を経由して経静脈的塞栓術を施行した1例を経験したので報告する.【症例】52歳,男性.右眼球結膜充血,眼球突出,複視を呈し,精査でACC近傍硬膜動静脈瘻と診断した.静脈流出路として下錐体静脈洞近位側が閉塞し,患側の海綿静脈洞から上眼静脈,顔面静脈が描出された.Triple coaxial systemにより長く蛇行した顔面静脈を経由してACCに到達し,塞栓術を施行した.【結論】眼症状を有するACC近傍硬膜動静脈瘻に対し,顔面静脈経由の経静脈的塞栓術は有効な治療の選択肢になり得ると考える.(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J06751&link_issn=&doc_id=20200514160003&doc_link_id=10.20626%2Fnkc.cr.2019-0004&url=https%3A%2F%2Fdoi.org%2F10.20626%2Fnkc.cr.2019-0004&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：English   Publisher：(NPO)日本脳神経血管内治療学会  

【目的】Multiple feedersを有する小脳テント部硬膜動静脈瘻に対する根治的Onyx塞栓術の1例を報告する。【症例】66歳、男性。Main feederは両側後頭動脈(OA)、静脈洞交会左の小脳テントにfistula pointを有し、主に上小脳虫部静脈から直静脈洞に流出していた。両側中硬膜動脈(MMA)からも、細径だが同部へshuntを認めた。両側OAをバルーンで一時遮断することで、両側MMAからOnyxをfistula pointに浸透させやすくする工夫により、根治的塞栓が行えた。【結論】Main feederをバルーンで一時遮断し、細径の標的血管からOnyx塞栓術を行う方法は有用である。(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J05194&link_issn=&doc_id=20200409220007&doc_link_id=10.5797%2Fjnet.tn.2019-0053&url=https%3A%2F%2Fdoi.org%2F10.5797%2Fjnet.tn.2019-0053&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(公財)日本心臓財団  

症例は27歳女性。頭痛、嘔吐、意識障害のため入院し、pial arteriovenous fistulae(pial AVF;脳軟膜動静脈瘻)に伴うくも膜下出血が認められた。降圧薬使用下に経動脈的塞栓術を施行した後に肺水腫をきたし、利尿薬に加え人工呼吸管理を要した。神経原性肺水腫も考えられたが、心臓カテーテル検査を行うと心拍出量は熱希釈法で14.55L/分、平均肺動脈楔入圧は17mmHgであり、高心拍出性心不全と診断した。このとき、上大静脈ばかりでなく、下肢から下大静脈にかけても静脈血酸素飽和度が90%以上と高く、高心拍出はpial AVFによるシャント血流に加え、末梢血管拡張により全身で血流が増加しているためと考えられた。β遮断薬に続き、再度経動脈的塞栓術を行うことで心拍出量が正常化し、以後心不全の再発はみられなかった。pial AVFに起因した高心拍出性心不全の成人症例はこれまで報告がなく、病態についての考察を交えて報告する。(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00679&link_issn=&doc_id=20200323220012&doc_link_id=20200323220013%2C20200323220014&url=http%3A%2F%2Fsearch.jamas.or.jp%2Flink%2Fbc%2F20200323220013%2C20200323220014&type=jamaslink&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F99999_1.gif

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND AND AIM: Although fluid-attenuated inversion recovery vascular hyperintensities may be frequently seen in acute large-artery ischemic stroke, reports on their prognostic utility had been conflicting due to lack of quantitative evaluation of the perfusion status based on the signal intensity. We hypothesized that greater hyperintensity represents more severe hypoperfusion. METHODS: Overall, 27 patients with acute occlusion of the proximal middle cerebral artery were divided into 2 groups, based on their signal intensity in the insular segment of middle cerebral artery on the affected side, relative to that of the insular cortex: the low signal intensity group (hypo- or isointense signals, n = 12) and the high signal intensity group (hyperintense signals, n = 15). Using dynamic susceptibility contrast magnetic resonance imaging, we assessed the time of the maximum value of the residue function and mean transit time, in the entire middle cerebral artery cortical area and diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomography Score regions, including the corona radiata. RESULTS: The high signal intensity group had significantly longer time of the maximum value of the residue function in all the diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomography Score regions, except the M3 and M6 regions, and significantly longer mean transit time in the M1 and M4 regions. CONCLUSIONS: Quantitative analysis of the perfusion parameters revealed more severely compromised and widely disturbed perfusion status in the high signal intensity group than in the low signal intensity group.

DOI： 10.1016/j.jstrokecerebrovasdis.2019.104467

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

Background: Morphological changes of a stented artery can cause a flow diversion effect to reduce intra-aneurysmal flow; however, there is a potential for the negative effect of increased intra-aneurysmal flow. We present cases with multiple overlapping stents for a partially thrombosed vertebral artery aneurysm and characterize the hemodynamic properties of a recurrent case by focusing on the morphological changes of the stented artery. Methods: Between October 2017 and April 2019, four consecutive cases of symptomatic unruptured large and giant partially thrombosed vertebral artery aneurysms were treated with multiple overlapping low-profile visualized intraluminal support stents and no coils. Both angiographic and clinical outcomes were assessed. Computational fluid dynamics analysis was performed to clarify hemodynamic features. The degree of pressure elevation was calculated as the pressure difference (Pd). Wall shear stress (WSS) was also calculated. Results: In three of the four cases, successful flow reduction was achieved with no morphological change of the stented arteries. The patients' symptoms were gradually improved. The remaining case required additional stents after the initial treatment. In the recurrent case, Pd was noticeably elevated at the aneurysm neck after treatment, and WSS was generally increased in the area due to altered blood flow into the aneurysm dome caused by morphological changes of the stented artery. Conclusion: Overlapping stents can be used for the treatment of large and giant thrombosed vertebral artery aneurysms with flow diversion effect; however, morphological changes of the stented artery requires careful attention as it may lead to an increase in the intra-aneurysmal flow, causing negative outcomes.

DOI： 10.3389/fneur.2020.611124

PubMed

researchmap

Language：Japanese   Publisher：新潟医学会  

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00990&link_issn=&doc_id=20201223020011&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10191%2F00052018&url=http%3A%2F%2Fhdl.handle.net%2F10191%2F00052018&type=%90V%8A%83%91%E5%8Aw%81F%90V%8A%83%91%E5%8Aw%8Aw%8Fp%83%8A%83%7C%83W%83g%83%8A_Nuar&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80230_3.gif

Language：Japanese   Publisher：(株)メディカ出版  

急性期主幹動脈閉塞(AIS)に対する血栓回収療法(MT)は、その高い有効性から最近急速に増加している治療法である。一方で、近年脳卒中に携わる医師の疲弊が指摘されており、いわゆる「燃え尽き症候群」が問題となっている。そのような状況を踏まえ、問題点の洗い出しにとどまらない脳卒中医の具体的な負担軽減策を講じておくことと並行して、現時点でMTを含めたAIS治療を組織的に運営していくシステム、すなわち脳卒中センターによる集約化を目的とした医療体制を整備しておくことが必要である。(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J03120&link_issn=&doc_id=20191115140004&doc_link_id=issn%3D0917-1495%26volume%3D29%26issue%3D11%26spage%3D1172&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0917-1495%26volume%3D29%26issue%3D11%26spage%3D1172&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

Language：English   Publishing type：Research paper (scientific journal)  

We retrospectively reviewed the cases of three patients with infectious intracranial aneurysms (IIAs), and discuss the indications for surgical and endovascular treatments. We treated two men and one woman with a total of six aneurysms. The mean age was 43.3 years, ranging from 36 to 51 years. One patient presented initially with an intraparenchymal hemorrhage, one with mass effect, and the other one had four aneurysms (one causing subarachnoid hemorrhages and the other causing delayed intraparenchymal hemorrhages). The average size of all aneurysms was 12.2 mm (range, 2-50 mm). They were preferentially located in the distal posterior cerebral artery, and then, in the middle cerebral artery. All cases were caused by infective endocarditis. We selected endovascular treatments for five aneurysms and treated all but one within 24 h from detection. One aneurysm was treated by combined therapy with endovascular intervention and surgery. After treatment, none of the IIAs presented angiographical recurrence or re-bleeding. If feasible, endovascular treatment is probably the first choice, but a combined surgical and endovascular approach should be considered if surgery or endovascular treatment alone are not feasible. The method of treatment should be individualized. For cases with high risk of aneurysm rupture, treatment should be performed as soon as possible.

DOI： 10.2176/nmc.oa.2019-0051

Scopus

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Schizencephaly is a rare congenital central nervous system malformation characterized by linear, thickened clefts of the cerebral mantle. Recently, germline mutations in collagen type IV alpha 1 (COL4A1) have been reported to be a genetic cause of schizencephaly as a result of prenatal stroke. Patients with COL4A1 mutation demonstrate a variety of disease phenotypes. However, little is known about the potential complications of patients with COL4A1 mutations before and after neurologic surgery. CASE DESCRIPTION: A 9-month-old boy with schizencephaly and a congenital cataract underwent a ventriculoperitoneal shunt for progressive hydrocephalus. Postoperatively, he developed malignant hyperthermia and cerebral venous thrombosis. Early treatment with dantrolene sodium and hydration was effective. Genetic testing revealed a germline COL4A1 mutation. CONCLUSIONS: To our knowledge, malignant hyperthermia and cerebral venous thrombosis have not been reported in the literature in patients with COL4A1 mutations after surgery. Schizencephaly arising from COL4A1 mutations might be a disease prone to these adverse effects because this mutation is known to be associated with venous tortuosity, venous vulnerability, and muscle spasms due to basement membrane protein abnormalities. We need to better understand the wide spectrum of clinical phenotypes of COL4A1 mutations and potential complications in order to better manage surgery of patients with schizencephaly.

DOI： 10.1016/j.wneu.2019.04.156

Scopus

PubMed

researchmap

Language：Japanese   Publisher：(株)メディカ出版  

＜POINT 1＞脳血管内治療と直達手術双方を行う術者をHybrid Neurosurgeonと定義する。＜POINT 2＞Spetzler-Martin grade 3以下のAVMに対して、plug &amp; push法による丹念なOnyx塞栓術に続いて外科的に摘出する治療成績は良好である。＜POINT 3＞脳動静脈奇形(AVM)の治療において、「自分でつめて自分でとる」メリットは大きく、Hybrid Neurosurgeonであることは治療成績向上に貢献できる。(著者抄録)

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J03120&link_issn=&doc_id=20190703140008&doc_link_id=issn%3D0917-1495%26volume%3D29%26issue%3D7%26spage%3D740&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0917-1495%26volume%3D29%26issue%3D7%26spage%3D740&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVELong-term follow-up results of the treatment of unruptured intracranial aneurysms (UIAs) by means of coil embolization remain unclear. The aim of this study was to analyze the frequency of rupture, retreatment, stroke, and death in patients with coiled UIAs who were followed for up to 20 years at multiple stroke centers.METHODSThe authors retrospectively analyzed data from cases in which patients underwent coil embolization between 1995 and 2004 at 4 stroke centers. In collecting the late (≥ 1 year) follow-up data, postal questionnaires were used to assess whether patients had experienced rupture or retreatment of a coiled aneurysm or any stroke or had died.RESULTSOverall, 184 patients with 188 UIAs were included. The median follow-up period was 12 years (interquartile range 11-13 years, maximum 20 years). A total of 152 UIAs (81%) were followed for more than 10 years. The incidence of rupture was 2 in 2122 aneurysm-years (annual rupture rate 0.09%). Nine of the 188 patients with coiled UIAs (4.8%) underwent additional treatment. In 5 of these 9 cases, the first retreatment was performed more than 5 years after the initial treatment. Large aneurysms were significantly more likely to require retreatment. Nine strokes occurred over the 2122 aneurysm-years. Seventeen patients died in this cohort.CONCLUSIONSThis study demonstrates a low risk of rupture of coiled UIAs with long-term follow-up periods of up to 20 years. This suggests that coiling of UIAs could prevent rupture for a long period of time. However, large aneurysms might need to be followed for a longer time.

DOI： 10.3171/2017.6.JNS17174

Scopus

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Intracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intracerebral haemorrhage growth, develop and validate prediction models, and evaluate the added value of CT angiography. METHODS: In a systematic review of OVID MEDLINE-with additional hand-searching of relevant studies' bibliographies- from Jan 1, 1970, to Dec 31, 2015, we identified observational cohorts and randomised trials with repeat scanning protocols that included at least ten patients with acute intracerebral haemorrhage. We sought individual patient-level data from corresponding authors for patients aged 18 years or older with data available from brain imaging initially done 0·5-24 h and repeated fewer than 6 days after symptom onset, who had baseline intracerebral haemorrhage volume of less than 150 mL, and did not undergo acute treatment that might reduce intracerebral haemorrhage volume. We estimated the absolute risk and predictors of the primary outcome of intracerebral haemorrhage growth (defined as >6 mL increase in intracerebral haemorrhage volume on repeat imaging) using multivariable logistic regression models in development and validation cohorts in four subgroups of patients, using a hierarchical approach: patients not taking anticoagulant therapy at intracerebral haemorrhage onset (who constituted the largest subgroup), patients taking anticoagulant therapy at intracerebral haemorrhage onset, patients from cohorts that included at least some patients taking anticoagulant therapy at intracerebral haemorrhage onset, and patients for whom both information about anticoagulant therapy at intracerebral haemorrhage onset and spot sign on acute CT angiography were known. FINDINGS: Of 4191 studies identified, 77 were eligible for inclusion. Overall, 36 (47%) cohorts provided data on 5435 eligible patients. 5076 of these patients were not taking anticoagulant therapy at symptom onset (median age 67 years, IQR 56-76), of whom 1009 (20%) had intracerebral haemorrhage growth. Multivariable models of patients with data on antiplatelet therapy use, data on anticoagulant therapy use, and assessment of CT angiography spot sign at symptom onset showed that time from symptom onset to baseline imaging (odds ratio 0·50, 95% CI 0·36-0·70; p<0·0001), intracerebral haemorrhage volume on baseline imaging (7·18, 4·46-11·60; p<0·0001), antiplatelet use (1·68, 1·06-2·66; p=0·026), and anticoagulant use (3·48, 1·96-6·16; p<0·0001) were independent predictors of intracerebral haemorrhage growth (C-index 0·78, 95% CI 0·75-0·82). Addition of CT angiography spot sign (odds ratio 4·46, 95% CI 2·95-6·75; p<0·0001) to the model increased the C-index by 0·05 (95% CI 0·03-0·07). INTERPRETATION: In this large patient-level meta-analysis, models using four or five predictors had acceptable to good discrimination. These models could inform the location and frequency of observations on patients in clinical practice, explain treatment effects in prior randomised trials, and guide the design of future trials. FUNDING: UK Medical Research Council and British Heart Foundation.

DOI： 10.1016/S1474-4422(18)30253-9

Scopus

PubMed

researchmap

Language：Japanese   Publisher：(株)メディカ出版  

＜開頭手術のポイント(まとめ)＞(1)前頭蓋底部dAVFは比較的まれであるが、出血発症が多く、積極的な治療を考慮すべき病態である(2)外科的治療は安全かつ確実にシャントを遮断することが可能な方法である(3)シャントポイントのjust distalで流出静脈を遮断することにより根治させることが可能である(著者抄録)

researchmap

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier B.V.  

Background Injury of the internal carotid artery (ICA) in the cavernous portion is one of the most critical complications of transsphenoidal surgery (TSS), especially in cases of coexistence with a pituitary adenoma (PA) and ICA aneurysm. Case description We present a rare case of unruptured medial paraclinoid ICA aneurysm (ICA-An) associated with symptomatic nonfunctioning giant PA. After endovascular coil embolization of the unruptured 4-mm saccular medial paraclinoid ICA-An, the patient underwent adenomectomy through an endoscopic endonasal TSS. During the bone resection over the right sellar floor near the right cavernous sinus, a tangle of packed coils in the treated medial paraclinoid ICA-An was observed immediately after a bite of a Kerrison rongeur. The dural layer over the coiled aneurysm had become thin to the point of transparency or complete absence. Careful inspection revealed that the bone hillock was formed by the medial paraclinoid ICA-An. Gross total resection of the adenoma was achieved without vascular injuries related to the coiled aneurysm despite postoperative transient right oculomotor paresis. Conclusions This case conveys three important lessons about TSS: 1) coil embolization will manage a medial paraclinoid ICA-An as a sufficient preoperative procedure for TSS
2) a medial paraclinoid ICA-An can appear directly under the sellar floor as an apparent extradural aneurysm
and
3) surgeons should take great care in procedures near a coil-embolized medial paraclinoid ICA-An because the aneurysmal wall can be thin to the point of transparency.

DOI： 10.1016/j.inat.2017.09.005

Scopus

researchmap

Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER ASSOC NEUROLOGICAL SURGEONS  

OBJECTIVE Arteriovenous malformations (AVMs) in the cerebellopontine angle cistern (CPAC) are specific lesions that can cause neurovascular compression syndromes as well as intracranial hemorrhage. Although case reports describing the CPAC AVMs, especially those presenting with trigeminal neuralgia (TN), have been accumulating by degrees, the pathophysiology of CPAC AVMs remains obscure. The authors' purpose in the present study was to evaluate the clinical and radiographic features of CPAC AVMs as well as the treatment options. METHODS This study defined a CPAC AVM as a small AVM predominantly located in the CPAC with minimal extension into the pial surface of the brainstem and closely associated with cranial nerves. All patients with CPAC AVMs treated in the authors' affiliated hospitals over a 16-year period were retrospectively identified. Clinical charts, imaging studies, and treatment options were evaluated. RESULTS Ten patients (6 men and 4 women), ranging in age from 56 to 77 years (mean 65.6 years), were diagnosed with CPAC AVMs according to the authors' definition. Six patients presented with hemorrhage, 3 with TN, and the remaining patient developed a hemorrhage subsequent to TN. Seven AVMs were associated with the trigeminal nerve (Group V), and 3 with the facial-vestibulocochlear nerve complex (Group VII-VIII). All patients in Group VII-VIII presented with the hemorrhage instead of hemifacial spasm. Regarding angioarchitecture, the intrinsic pontine arteries provided the blood supply for all CPAC AVMs in Group V. In addition, 5 of 7 AVMs with hemorrhagic episodes accompanied flow-related aneurysms, although no aneurysm was detected in patients with TN alone. With respect to treatment, all patients with hemorrhagic presentation underwent Gamma Knife surgery (GKS), resulting in favorable outcomes except for 1 patient who experienced rebleeding after GKS, which was caused by the repeated rupture of a feeder aneurysm. The AVMs causing TN were managed with surgery, GKS, or a combination, according to the nidus-nerve relationship. All patients eventually obtained pain relief. CONCLUSIONS Clinical symptoms caused by CPAC AVMs occur at an older age compared with AVMs in other locations; CPAC AVMs also have distinctive angioarchitectures according to their location in the CPAC. Although GKS is likely to be an effective treatment option for the CPAC AVMs with hemorrhagic presentations, it seems ideal to obliterate the flow-related aneurysms before performing GKS, although this is frequently challenging. For CPAC AVMs with TN, it is important to evaluate the nidus-nerve relationship before treatment, and GKS is especially useful for patients who do not require urgent pain relief.

DOI： 10.3171/2015.12.JNS152190

Web of Science

Scopus

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

BACKGROUND: Although the introduction of flow-diverter stents has been recognized as a major revolution in the treatment of cavernous carotid aneurysms (CCAs), therapeutic internal carotid artery occlusion (TICAO) remains a reliable procedure for alleviating symptoms caused by CCAs. However, TICAO has the potential risk of the enlargement of coexisting aneurysms that are frequently detected in CCA patients. The purpose of this study is to assess the occurrence of the enlargement of aneurysms coexisting with CCAs after TICAO. METHODS: We reviewed medical charts of CCA patients who were managed using unilateral TICAO. Coexisting aneurysms were identified using angiograms obtained before TICAO, and imaging data in long follow-up periods were retrospectively examined to determine the extent of the enlargement after TICAO. RESULTS: Of 12 patients with CCAs, 10 had 12 coexisting aneurysms; 5 of the coexisting aneurysms (41.7%) showed enlargement during a mean follow-up period of 8.1 years, and all enlarged aneurysms were smaller of the bilateral CCAs; the larger CCA had been managed by TICAO. Five of 6 (83.3%) patients with bilateral CCAs showed enlargement of the contralateral aneurysm after TICAO. Two contralateral CCAs showed marked enlargement after TICAO and were subsequently treated with stent-assisted coil embolization. CONCLUSIONS: Contralateral, smaller aneurysms frequently enlarge after unilateral TICAO in patients with bilateral CCAs. The findings emphasize the importance of long-term observation after TICAO and appropriate interventions against enlarging contralateral aneurysms.

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.025

Web of Science

Scopus

PubMed

researchmap

Language：Japanese   Publisher：(一社)日本脳卒中の外科学会  

2010年1月〜2014年6月に著者らの施設へ紹介された脳動静脈奇形(AVM)において、治療を受けた34例のうち、ONYX液体塞栓システム(Onyx)を施行した11例(男性3例、女性8例、年齢12〜62歳、平均年齢35.3歳)の手術成績を検討した。その結果、1)対象の初発症状は出血が6例、てんかんが2例で、Spetzler-Martin gradeはgrade 2が7例、grade 1が2例、grade 3とgrade 4が各1例であった。2)11例に対し13回のOnyx塞栓術が施行され、10例で50%以上のnidusの閉塞が得られ、うち6例では80%以上の閉塞が得られた。3)手技に伴う合併症は3例にみられ、1例のみが一時的に新たな神経症状を呈したが最終的には消失した。また、摘出術によるmodified Rankin Scale低下を1例で認められたが、これは無症候例で術後に軽度の視野障害が遺残したものあった。一方、nidusが残存した1例があったが、ガンマナイフの施行により3年後には消失が確認された。4)AVM摘出術は塞栓によりnidusが完全遮断の場合以外は可能な限り残存feederを遮断し、次いでnidus周囲のくも膜を全周性に剥離後、Onyx充填のfeederを切断、最後にmain drainer切断後にnidusを摘出、周囲の白質に残存nidusがないことが確認された。

DOI： 10.2335/scs.43.283

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J02079&link_issn=&doc_id=20150812200007&doc_link_id=%2Fcp4strok%2F2015%2F004304%2F007%2F0283-0288%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp4strok%2F2015%2F004304%2F007%2F0283-0288%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER ASSOC NEUROLOGICAL SURGEONS  

The authors report a rare case of a huge hypervascular tentorial cavernous angioma treated with preoperative endovascular embolization, followed by successful gross-total removal. A 15-year-old girl presented with scintillation, diplopia, and papilledema. Computed tomography and MRI studies revealed a huge irregularly shaped tumor located in the right occipital and suboccipital regions. The tumor, which had both intra- and extradural components, showed marked enhancement and invasion of the overlying occipital bone. Angiography revealed marked tumor stain, with blood supply mainly from a large branch of the left posterior meningeal artery. Therefore, this lesion was diagnosed as a tentorium-based extraaxial tumor. For differential diagnosis, meningioma, hemangiopericytoma, and malignant skull tumor were considered. Tumor feeders were endovascularly embolized with particles of polyvinyl alcohol. On the following day, the tumor was safely gross totally removed with minimum blood loss. Histopathological examination confirmed the diagnosis of cavernous angioma. To date, there have been no reports of tentorium-based cavernous angiomas endovascularly embolized preoperatively. A tentorial cavernous angioma is most likely to show massive intraoperative bleeding. Therefore, preoperative embolization appears to be quite useful for safe maximum resection. Hence, the authors assert that the differential diagnosis of tentorium-based tumors should include tentorial cavernous angioma, for which preoperative endovascular embolization should be considered.

DOI： 10.3171/2014.4.PEDS13628

Web of Science

Scopus

PubMed

researchmap

Language：Japanese   Publisher：日本老年脳神経外科学会事務局  

CiNii Article

CiNii Books

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

【目的】摘出術前の直接穿刺による腫瘍塞栓術中に外頸動脈へのNBCA(n-butyl-2-cyanoacrylate)のmigrationを認めた頸動脈小体腫瘍の1例を報告する.【症例】42歳,女性.徐々に増大し,圧痛を伴う左頸部腫瘤を自覚.頸動脈小体腫瘍と診断し,摘出術に先行して腫瘍塞栓術を行った.経皮的に腫瘍を直接穿刺しロードマップガイド下に20%NBCAによる塞栓術を行い,完全な腫瘍濃染の消失を認めた.塞栓術終了直前にNBCAが外頸動脈の分枝に逆流し,外頸動脈分枝閉塞をきたしたが,症状は出現しなかった.塞栓術翌日に腫瘍摘出術が施行され,約200mlと少ない出血量で全摘出が行われた.【結論】NBCAを用いた直接穿刺による塞栓術は頸動脈小体腫瘍の術前塞栓術として有用であると思われる.しかし,周辺血管への塞栓物質迷入に充分な注意が必要である.(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J05194&link_issn=&doc_id=20110808360006&doc_link_id=%2Fcf5jneth%2F2011%2F000501%2F006%2F0043-0049%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf5jneth%2F2011%2F000501%2F006%2F0043-0049%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(株)メディカ出版  

28歳男。7年前の転落事故により左眼球突出および視力低下が残存していた。突然意識消失を来たし救急搬送され、CTで左側頭葉内出血、脳室内出血、造影剤で増強される拡張した左海綿静脈洞およびシルビウス裂の静脈を認めた。脳血管造影では左内頸動脈海綿静脈洞瘻(CCF)を認め、C3部の瘻孔から拡張した左海綿静脈洞と中大脳静脈への造影剤逆流があり、逆流により左上眼静脈が造影された。両側下錐体静脈洞への流出も認めた。Traumatic CCFに伴う脳静脈圧上昇を原因とする頭蓋内出血と診断し、血管内治療を行った。全身麻酔下に右大腿動脈経由でアプローチして左内頸動脈に9Frガイディングカテーテルを留置し、detachable balloonをマウントした2Fr/3Fr同軸カテーテルを左内頸動脈C3部の瘻孔部に進めた。造影剤を用いてballoonをinflationすると、静脈へのshuntは消失して頭蓋内内頸動脈が描出され、強い狭窄がないことを確認後に同部位でballoonをdetachした。直後の血管造影ではCCFの完全消失を確認できた。症状は徐々に改善し術後2ヵ月で消失し、左視力障害が残存したものの社会復帰した。

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J03120&link_issn=&doc_id=20110712220010&doc_link_id=issn%3D0917-1495%26volume%3D21%26issue%3D7%26spage%3D782&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0917-1495%26volume%3D21%26issue%3D7%26spage%3D782&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

【目的】海綿静脈洞部硬膜動静脈瘻(CS dAVF)に対する経静脈的塞栓術で,マイクロカテーテル(MC)プルアップ法が有用だった1例を報告する.【症例】76歳,女性.CS dAVFによる右眼症状を認めた.通常の方法では右CSへ到達できなかった.ガイドワイヤー(GW)を左下錐体静脈洞(IPS)からposterior intercavernous sinusと右IPSを介し右内頸静脈(IJV)へ誘導,右IJVの近位から誘導したグースネックスネアで捕捉した.GWと共にグースネックスネアとMCを右IPSへ引き上げ,さらに右CS内へ誘導しコイル塞栓を施行,症状は消失した.【結論】MCプルアップ法は,CSへ到達困難な症例に有効な場合がある.(著者抄録)

DOI： 10.5797/jnet.5.68

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J05194&link_issn=&doc_id=20110808360010&doc_link_id=%2Fcf5jneth%2F2011%2F000501%2F010%2F0068-0073%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf5jneth%2F2011%2F000501%2F010%2F0068-0073%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER WIEN  

CLINICAL DESCRIPTION: We report two cases of asymptomatic cerebral aneurysm in which cranial nerve palsy (CNP) developed shortly after symbolization. The CNP occurred immediately in case 1, but case 2 showed the CNP 30 h after symbolization. Although both aneurysms had increased in size on follow-up angiography, case 2 who showed dome re canalization resulted in progressive CNP deterioration. CONCLUSION: These findings suggest that the CNP may result not only from mechanical compression by coils but also from inflammation induced by perpendicular thrombosis, and that the prognosis of the CNP may be influenced by dome re canalization. This complication should be kept in mind in treatment for asymptomatic aneurysms adjacent to the cranial nerves.

DOI： 10.1007/s00701-009-0234-4

Web of Science

Scopus

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER ASSOC NEUROLOGICAL SURGEONS  

OBJECT: Transvenous embolization (TVE) for the treatment of a cavernous sinus (CS) dural arteriovenous fistula (DAVF) occasionally causes cranial nerve palsy (CNP). Overpacking of coils is considered to result in CNP. The purpose of this study was to analyze the association of TVE-induced CNP with the volume and location of coils activated in the CS. METHODS: Thirty-one patients with CS DAVFs (33 lesions) underwent TVE. RESULTS: Cranial nerve palsy occurred or was aggravated in 13 cases (39.4%; CNP group). The cumulative volume of activated coils was significantly greater in the CNP group (0.241 +/- 0.172 cm3) than in the non-CNP group (0.119 +/- 0.075 cm3; p < 0.05). Of those lesions with > 0.2 cm3 of coil volume, 77.8% showed immediate aggravation or a new occurrence of CNP after TVE. Five lesions treated with a smaller volume of coils showed a delayed worsening or occurrence of CNP. In cases with induced oculomotor nerve palsy, coils had been densely packed in the superolateral part of the anterior CS. Dense packing in the lateral portion of the posterior CS frequently induced abducent nerve palsy. Although patients harboring lesions with a greater coil volume required a longer recovery time, newly developed or aggravated CNP, related to 84.6% of the lesions, resolved completely. CONCLUSIONS: The cumulative volume and specific locations of coils in the CS correlated with TVE-induced CNP. Overpacking appeared to be the predominant cause of CNP; however, for CNP in cases involving smaller coil volumes, an alternative mechanism may be involved.

DOI： 10.3171/JNS/2008/109/8/0208

Web of Science

Scopus

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

INTRODUCTION: In coil embolization of a posterior circulation aneurysm, tortuosity or a small vessel caliber frequently prevents placement of a guiding catheter in the vertebral artery. Even in such difficult situations, however, coil embolization is the only treatment option when the patient's clinical condition is very poor, or the aneurysm is inaccessible by microsurgery. METHODS: Three patients with a posterior circulation aneurysm were treated by coil embolization with the use of a modified buddy wire technique to stabilize a guiding catheter that could not be placed into the vertebral artery. RESULTS: The guiding catheter was stabilized in the subclavian artery and the microcatheter was firmly supported. As a result, coil embolization was performed safely in all patients. There were no procedural complications. CONCLUSION: The modified buddy wire technique could provide patients with a chance to undergo endovascular surgery despite having a tortuous or narrow vertebral artery.

DOI： 10.1007/s00234-006-0154-4

Web of Science

Scopus

PubMed

researchmap

Language：Japanese   Publisher：新潟医学会  

小脳運動失調と欠神てんかんを特徴とする変異マウスStargazerの解析により,その原因遺伝子であるstargazin(VDCCγ-2)がAMPA型受容体と機能的に密接な関係にあることが示された.この分子と相同性が高い電位依存性カルシウムチャネル(VDCC)γ-3,4,7,8も,AMPA型受容体の機能発現に重要な補助的サブユニットであることが示唆されているが,個体レベルでの解析に乏しく,その機能や役割分担については未解明の部分が多い.本研究では海馬で高い発現を示すγ-8サブユニットに着目し,海馬CA3特異的にこの分子を欠失させ,AMPA型受容体を介した脳の分子機構の解明を計画した.そのためにCre/loxPシステムにより,部位・時期特異的にVDCCγ-8を欠失できるマウスγ8-flox系統を樹立した.そしてこのマウスと全身でCreリコンビネースを発現するマウスとを交配することによりVDCCγ-8がCre活性依存的に欠失することを確認した.さらに,VDCCγ-8の欠失は,AMPA型受容体のタンパク発現に選択的に影響を及ぼすことも示唆された.本研究で樹立したVDCCγ-8KOマウスは,特にAMPA型受容体の関与する神経分子機構の個体レベルでの解析において有用なツールとなると考えられる(著者抄録)

CiNii Article

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2006&ichushi_jid=J00990&link_issn=&doc_id=20060622220002&doc_link_id=%2Fdg3nigta%2F2006%2F012004%2F002%2F0203-0213%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2006%2F012004%2F002%2F0203-0213%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Association of Neurological Surgeons  

The lateral spread response (LSR) is used in the electrophysiological diagnosis of a hemifacial spasm or for monitoring during microvascular decompression. The authors used LSRs for intraoperative monitoring during endovascular surgery in a rare case of vertebral artery (VA) aneurysm that caused intractable hemifacial spasm. A 49-year-old woman presented with a right hemifacial spasm that had persisted for 9 months. No other clinical symptom was observed. Vertebral artery angiography revealed a saccular aneurysm of the right VA. Magnetic resonance (MR) imaging demonstrated that the aneurysm was compressing the root exit zone of the right facial nerve. Endovascular treatment of the VA aneurysm was performed while monitoring the patient's LSRs. During occlusion of the VA at sites distal and proximal to the aneurysm, the LSRs temporarily disappeared and then reappeared with a higher amplitude than those measured preceding their disappearance. The hemifacial spasm alleviated gradually and disappeared completely 6 months after treatment. The LSRs changed in parallel with the improvement in the patient's hemifacial spasms and eventually disappeared. No recurrence of symptoms has been noticed as of 18 months postoperatively. This is the first report of the use of LSR monitoring during endovascular surgery for an intracranial aneurysm that causes hemifacial spasm. Intraoperative and postoperative changes in the LSRs provided useful information regarding the pathophysiology of hemifacial spasm.

DOI： 10.3171/jns.2004.101.5.0861

Scopus

PubMed

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J00650&link_issn=&doc_id=20040909190002&doc_link_id=%2Fco2socie%2F2004%2F002904%2F002%2F0290-0297%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fco2socie%2F2004%2F002904%2F002%2F0290-0297%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER ASSOC NEUROLOGICAL SURGEONS  

OBJECT: The aim of this study was to investigate further immunogene treatment of malignant brain tumor to improve its therapeutic efficacy. METHODS: Intratumoral dendritic cells pulsed with Semliki Forest virus (SFV)-interleukin-18 (IL-18) and/or systemic IL-12 were injected into mice bearing the B16 brain tumor. To study the immune mechanisms involved in tumor regression, we monitored the growth of implanted B16 brain tumor cells in T cell-depleted mice and IFNgamma-neutralized mice. To analyze the protective immunity created by tumor inoculation, B16 cells were injected into the left thighs of mice that had received an inoculation, and tumor growth was monitored. The local delivery of dendritic cells pulsed with IL-18 bound by SFV combined with the systemic administration of IL-12 enhanced the induction of the T helper type 1 response from tumor-specific CD4+ and CD8+ T cells and natural killer cells as well as antitumor immunity. Interferon-gamma is partly responsible for this IL-18-mediated antitumor immunity. Furthermore, the protective immunity is mediated mainly by CD8+ T cells. CONCLUSIONS: Immunogene therapy that combines the local administration of dendritic cells pulsed with IL-18 bound by SFV and the systemic administration of IL-12 may be an excellent candidate for the development of a new treatment protocol. A self-replicating SFV system may therefore open a novel approach for the treatment of malignant brain tumor.

DOI： 10.3171/jns.2003.99.4.0746

Web of Science

PubMed

researchmap

Language：Japanese   Publisher：The Japanese Society on Surgery for Cerebral Stroke  

To examine flowdynamic change after superficial temporal artery (STA)-middle cerebral artery (MCA) bypass surgery, we measured the pulsatility index (PI) and end-diastolic blood flow velocity (Vd) of the donor STA by percutaneous direct microvascular Doppler sonography. In 63 patients (5-76 y/o) who had received STA-MCA bypass surgery for either ischemic stroke (11 cases), supportive therapy before parent artery occlusion in the treatment of internal carotid giant aneurysm (3 cases), or moyamoya disease (49 cases) (total 96 sides of STA), PI was 1.01±0.41 and Vd was 18.9±8.4 cm/sec. When compared to normal volunteers (6-76 y/o, 70 sides of STA) (PI: 1.96±0.63 and Vd: 5.6±2.5 cm/sec), PI decreased and Vd increased after STA-MCA bypass with high statistical significance (p&lt;0.0001 and p&lt;0.0001, respectively). Low PI and high Vd indicate that STA flow has changed from extracranial flow to intracranial flow. STA flowdynamics can be quantitatively assessed by measuring PI and Vd of the donor STA. This new bedside method is easy, noninvasive and useful to identify functional patency of the STA-MCA bypass.

DOI： 10.2335/scs.31.355

CiNii Article

researchmap

The purpose of this study was to evaluate the role of the endothelial cell reaction after endovascular coil embolization for the treatment of intracranial aneurysms. A scanning electron microscopic (SEM) study of the platinum coil, embolized into a middle cerebral aneurysm in a 35-year-old woman and subsequently removed surgically eight months later, revealed no endothelial coverage on the coil. This finding prompted us to perform experimental studies. In the first in vitro study, endothelial cells from gerbil brain microvessels and canine carotid arteries were co-cultured with either bare-form platinum coils or type-1 collagen-coated coils for up to three weeks, and the endothelial cell population on the coils was ascertained. In the second in vivo study, platinum coils coated with type-1 collagen were delivered endovascularly into canine carotid arteries, while the contralateral side was treated with bare-form coils, and endothelialization over the coil was investigated. SEM studies revealed that no endothelial cells, either from gerbil brain microvessels or from canine carotid artery, were found on the uncoated coils, whereas gerbil endothelial cells began to proliferate on the collagen-coated coils in three days, covering extensively in one week and reaching confluence in two weeks in vitro. The in vivo canine study demonstrated that bare-form platinum coils did not show endothelial coverage until two weeks, but endothelial cells proliferated directly on the collagen-coated coils in three days, and coils were completely covered in two weeks. These results supported the SEM study of our case and several human histopathological reports in the literature in that endothelial cell coverage in the orifice of the intracranial aneurysm is exceptional after endovascular treatment. But if some extracellular matrix, like collagen in our study, is prepared, coverage could be possible, as is seen in a few human cases. Biological modification of the platinum coils, such as collagen coating, is awaited for the better long-term results of endovascular coil embolization without recanalization of the treated intracranial aneurysms.

Scopus

researchmap

Total pages：319p   Language：Japanese

CiNii Books

researchmap

Total pages：viii, 165p   Language：Japanese

CiNii Books

researchmap

Total pages：xii, 189p   Language：Japanese

CiNii Books

researchmap

Total pages：xii, 355p   Language：Japanese

CiNii Books

researchmap

Total pages：xii, 203p   Language：Japanese

CiNii Books

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：日本脳神経超音波学会・日本栓子検出と治療学会  

researchmap

Language：Japanese   Publisher：日本コミュニケーション障害学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

【目的】動脈瘤破裂による直接型内頸動脈海綿静脈洞瘻に対する,MRA元画像・再構成画像の初期診断・評価と,ステント支援下コイル塞栓術の有用性について報告する.【症例】73歳女性.突然の右眼症状が出現.MRA元画像・再構成画像により,右内頸動脈海綿静脈洞部動脈瘤破裂による内頸動脈海綿静脈洞瘻と初期診断し,治療に必要な情報が得られた.3D-CT・RAで確認後にステント支援下のコイル塞栓術を行い,動静脈瘻は消失し,症状も消失した.【結語】MRA元画像・再構成画像により初期診断された動脈瘤破裂による直接型内頸動脈海綿静脈洞瘻に経動脈的ステント支援下の破裂動脈瘤コイル塞栓術を行い,短時間で経済的に治療することができた.(著者抄録)

researchmap

Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J06751&link_issn=&doc_id=20210527200008&doc_link_id=%2Fcf5nokec%2F2021%2F000601%2F008%2F0049-0057%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf5nokec%2F2021%2F000601%2F008%2F0049-0057%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(一社)日本小児神経外科学会  

researchmap

Language：Japanese   Publisher：(一社)日本神経学会  

右側視野内に視野欠損を伴わない複雑幻視を呈した76歳の女性。脳波検査ではT5、P3を焦点とする鋭一過性波を認めた。頭部MRIでは左下部側頭葉を中心に左側頭後頭葉白質に信号変化を認めた。脳血管造影法で左後頭動脈から左横静脈洞に血流を認め、硬膜動静脈瘻(dural arteriovenous fistula;DAVF)と診断した。経動脈塞栓術後に複雑幻視は消失した。本症例の幻視はDAVFに伴うてんかん発作や皮質の血流変化による可能性を考えた。一般に複雑幻視は、てんかん性幻視は全視野にわたって出現し、一側性の場合は欠損視野内に出現する盲視野内幻視となる。本例は視野欠損を伴わずに一側性の複雑幻視が生じた点、DAVFが複雑幻視を呈した点で、貴重な症例と考えた。(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01550&link_issn=&doc_id=20200615340005&doc_link_id=130007852588&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007852588&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Language：Japanese   Publisher：(株)医学書院  

46歳男。主訴は左片麻痺で、発症から63分後に救急搬送され、CTでは右中大脳動脈近位部にhyperdense signを認めた。3D-CT angiographyでは右頸部内頸動脈起始部の高度狭窄と頭蓋内内頸動脈以遠の閉塞を認めた。前日に剣道で右前頸部へ直接突きを受けており、鈍的外傷による右頸部内頸動脈解離と同部由来の塞栓による頭蓋内内頸動脈閉塞、急性期脳梗塞と診断した。到着から109分後に血管内再開通療法を開始し、内頸動脈起始部の狭窄部にステント留置を先行させ、その後総頸動脈遮断下に閉塞した内頸動脈終末部を直接吸引して血栓を回収した。再開通までは発症から245分であった。術後頭部MRIでは、右被殻、尾状核頭、島皮質、前頭葉弁蓋部、側頭葉内側に梗塞巣を認めたが、症状は劇的に改善し、23病日には軽度の注意障害を残し、modified Rankin Scale 1で退院した。

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01228&link_issn=&doc_id=20200626070011&doc_link_id=10.11477%2Fmf.1436204223&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1436204223&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Language：Japanese   Publisher：新潟医学会  

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00990&link_issn=&doc_id=20201223020011&doc_link_id=%2Fdg3nigta%2F2019%2Fs13311%2F004%2F0389-0389%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2019%2Fs13311%2F004%2F0389-0389%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00990&link_issn=&doc_id=20200130080009&doc_link_id=%2Fdg3nigta%2F2018%2Fs13211%2F006%2F0399-0400%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2018%2Fs13211%2F006%2F0399-0400%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J00990&link_issn=&doc_id=20171214030016&doc_link_id=%2Fdg3nigta%2F2017%2Fs13107%2F008%2F0445-0445%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2017%2Fs13107%2F008%2F0445-0445%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese   Publisher：新潟医学会  

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J00990&link_issn=&doc_id=20171214030021&doc_link_id=%2Fdg3nigta%2F2017%2Fs13107%2F013%2F0447-0447%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2017%2Fs13107%2F013%2F0447-0447%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(株)メディカ出版  

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J03120&link_issn=&doc_id=20160808240008&doc_link_id=issn%3D0917-1495%26volume%3D26%26issue%3D8%26spage%3D838&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0917-1495%26volume%3D26%26issue%3D8%26spage%3D838&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

Language：Japanese   Publisher：(株)メディカ出版  

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J03120&link_issn=&doc_id=20160609170009&doc_link_id=issn%3D0917-1495%26volume%3D26%26issue%3D6%26spage%3D628&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0917-1495%26volume%3D26%26issue%3D6%26spage%3D628&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00990&link_issn=&doc_id=20160108150054&doc_link_id=%2Fdg3nigta%2F2015%2Fs12908%2F048%2F0490-0490%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2015%2Fs12908%2F048%2F0490-0490%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese  

DOI： 10.15105/J00235.2015304823

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J00990&link_issn=&doc_id=20150512080015&doc_link_id=%2Fdg3nigta%2F2014%2Fs12812%2F007%2F0682-0683%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2014%2Fs12812%2F007%2F0682-0683%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J00990&link_issn=&doc_id=20140603150013&doc_link_id=%2Fdg3nigta%2F2014%2Fs12801%2F006%2F0040-0040%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2014%2Fs12801%2F006%2F0040-0040%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

CiNii Article

CiNii Books

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J05194&link_issn=&doc_id=20131119210063&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10623%2F76228&url=http%3A%2F%2Fhdl.handle.net%2F10623%2F76228&type=%90V%8A%83%8C%A7%92n%88%E6%8B%A4%93%AF%83%8A%83%7C%83W%83g%83%8A%81FNiRR%3A_Niigata_Regional_Repository&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80148_3.gif

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

CiNii Article

CiNii Books

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J05194&link_issn=&doc_id=20131119210064&doc_link_id=%2Fcf5jneth%2F2013%2F000706%2F064%2F0160-0160%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf5jneth%2F2013%2F000706%2F064%2F0160-0160%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese  

CiNii Article

CiNii Books

J-GLOBAL

researchmap

Language：Japanese   Publisher：日本脳神経血管内治療学会  

CiNii Article

CiNii Books

researchmap

Language：Japanese   Publisher：日本脳神経血管内治療学会  

CiNii Article

CiNii Books

researchmap

Language：Japanese  

CiNii Article

CiNii Books

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J00990&link_issn=&doc_id=20121205090008&doc_link_id=%2Fdg3nigta%2F2012%2Fs12607%2F004%2F0374-0375%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2012%2Fs12607%2F004%2F0374-0375%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J00990&link_issn=&doc_id=20120203090009&doc_link_id=%2Fdg3nigta%2F2011%2F012508%2F009%2F0452-0452%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2011%2F012508%2F009%2F0452-0452%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J00990&link_issn=&doc_id=20110609090009&doc_link_id=%2Fdg3nigta%2F2011%2F012502%2F009%2F0104-0104%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2011%2F012502%2F009%2F0104-0104%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J00990&link_issn=&doc_id=20110322130017&doc_link_id=%2Fdg3nigta%2F2010%2F012412%2F017%2F0715-0716%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2010%2F012412%2F017%2F0715-0716%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(株)医薬情報研究所  

2008年4月以降の著者らの施設における頸動脈ステント留置術(CAS)施行の25症例(男性22例、女性3例、平均72.3±6.7際)27病変を対象に初期成績、術後および脳梗塞慢性期の抗血小板療法について検討した。その結果、周術期神経症状を11病変(41%)に認めたが一過性で最高48時間継続して回復し、永久的合併症は認めず良好な結果であった。CAS周術期以降の抗血小板療法として、ステント血栓症予防を目的に一定期間は強力な抗血小板療法が必要とされる。糖尿病などのリスク因子を合併しているような脳梗塞再発患者では、漫然とアスピリンの投与を継続するよりクロピドグレルのような強力な抗血小板薬への積極的な切り替えを考えるべきである。服薬コンプライアンス向上のためには「なぜこの薬剤を選択したのか」についてその根拠を患者およびかかりつけ医にきちんと提示することが重要と考えられた。

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2009&ichushi_jid=J00990&link_issn=&doc_id=20100416060025&doc_link_id=%2Fdg3nigta%2F2009%2F012312%2F025%2F0642-0642%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2009%2F012312%2F025%2F0642-0642%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J00990&link_issn=&doc_id=20071101080040&doc_link_id=%2Fdg3nigta%2F2007%2F012107%2F040%2F0422-0423%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2007%2F012107%2F040%2F0422-0423%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J00990&link_issn=&doc_id=20070905100071&doc_link_id=%2Fdg3nigta%2F2007%2F012104%2F071%2F0231-0232%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2007%2F012104%2F071%2F0231-0232%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese   Publisher：新潟医学会  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J00990&link_issn=&doc_id=20070725060066&doc_link_id=%2Fdg3nigta%2F2007%2F012103%2F066%2F0181-0182%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2007%2F012103%2F066%2F0181-0182%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese   Publisher：日本脳腫瘍病理学会  

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J00990&link_issn=&doc_id=20041202160074&doc_link_id=%2Fdg3nigta%2F2004%2F011810%2F074%2F0564-0564%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2004%2F011810%2F074%2F0564-0564%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J00990&link_issn=&doc_id=20040420410105&doc_link_id=%2Fdg3nigta%2F2004%2F011801%2F105%2F0071-0071%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2004%2F011801%2F105%2F0071-0071%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese  

CiNii Article

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2003&ichushi_jid=J00650&link_issn=&doc_id=20031224320003&doc_link_id=%2Fco2socie%2F2003%2F002806%2F003%2F0402-0408%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fco2socie%2F2003%2F002806%2F003%2F0402-0408%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：(一社)日本小児神経外科学会  

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2003&ichushi_jid=J00990&link_issn=&doc_id=20030619020022&doc_link_id=%2Fdg3nigta%2F2003%2F011702%2F023%2F0101-0102%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2003%2F011702%2F023%2F0101-0102%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2002&ichushi_jid=J00990&link_issn=&doc_id=20021225090019&doc_link_id=%2Fdg3nigta%2F2002%2F011608%2F020%2F0401-0401%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2002%2F011608%2F020%2F0401-0401%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2002&ichushi_jid=J00990&link_issn=&doc_id=20021225090017&doc_link_id=%2Fdg3nigta%2F2002%2F011608%2F018%2F0400-0400%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2002%2F011608%2F018%2F0400-0400%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：(一社)日本小児神経外科学会  

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

CiNii Books

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

CiNii Article

CiNii Books

researchmap

Language：Japanese  

CiNii Article

CiNii Books

J-GLOBAL

researchmap

Language：Japanese  

CiNii Article

CiNii Books

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

CiNii Books

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2000&ichushi_jid=J00990&link_issn=&doc_id=20010213300037&doc_link_id=%2Fdg3nigta%2F2000%2F011412%2F037%2F0490-0490%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2000%2F011412%2F037%2F0490-0490%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Language：Japanese  

CiNii Article

CiNii Books

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

CiNii Books

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese  

J-GLOBAL

researchmap

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2000&ichushi_jid=J00990&link_issn=&doc_id=20000309070003&doc_link_id=%2Fdg3nigta%2F2000%2F011401%2F003%2F0011-0011%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2000%2F011401%2F003%2F0011-0011%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese   Publisher：新潟医学会  

CiNii Article

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=1999&ichushi_jid=J00990&link_issn=&doc_id=19991221370033&doc_link_id=%2Fdg3nigta%2F1999%2F011311%2F034%2F0546-0546%26dl%3D2&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F1999%2F011311%2F034%2F0546-0546%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

Language：Japanese  

J-GLOBAL

researchmap