2021/10/20 更新

写真a

イズミ ダイスケ
和泉 大輔
IZUMI Daisuke
所属
教育研究院 医歯学系 医学系列 助教
医歯学総合研究科 生体機能調節医学専攻 器官制御医学 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2007年3月   新潟大学 )

研究キーワード

  • 抗凝固療法

  • 心室頻拍

  • 心房細動

  • 不整脈学

研究分野

  • ライフサイエンス / 薬理学

  • ライフサイエンス / 循環器内科学

  • ライフサイエンス / 血液、腫瘍内科学

  • ライフサイエンス / 内科学一般

経歴

  • 新潟大学   医歯学総合研究科 生体機能調節医学専攻 器官制御医学   助教

    2017年5月 - 現在

  • 新潟大学   医歯学総合病院 循環器内科   助教

    2015年4月 - 2017年4月

  • 新潟大学   医歯学総合病院 不整脈センター   特任助教

    2012年9月 - 2015年3月

所属学協会

 

論文

  • Replacement of an Implantable Cardioverter-Defibrillator (ICD) with a New Standard Subcutaneous ICD System in a Patient with Jervell and Lange-Nielsen Syndrome. 査読

    Sato A, Hasegawa Y, Haniu H, Shiraishi S, Yagihara N, Iijima K, Izumi D, Minamino T

    International heart journal   60 ( 5 )   1206 - 1210   2019年9月

  • Early repolarization and risk of lone atrial fibrillation. 査読

    Hasegawa Y, Watanabe H, Ikami Y, Otsuki S, Iijima K, Yagihara N, Sato A, Izumi D, Minamino T

    Journal of cardiovascular electrophysiology   30 ( 4 )   565 - 568   2019年1月

  • A Steam Pop Detected by Intracardiac Echocardiography During Catheter Ablation of the Left Ventricular Papillary Muscle. 査読

    Sato A, Yagihara N, Hasegawa Y, Otuki S, Iijima K, Izumi D, Minamino T

    International heart journal   2018年11月

  • Clinical Predictors of Recurrent Ventricular Arrhythmias in Secondary Prevention Implantable Cardioverter Defibrillator Recipients With Coronary Artery Disease - Lower Left Ventricular Ejection Fraction and Incomplete Revascularization. 査読

    Takano T, Tanaka K, Ozaki K, Sato A, Iijima K, Yanagawa T, Izumi D, Ozawa T, Fuse K, Sato M, Tanabe N, Minamino T

    Circulation journal : official journal of the Japanese Circulation Society   82 ( 12 )   3037 - 3043   2018年11月

  • Effects of Direct Oral Anticoagulants at the Peak Phase, Trough Phase, and After Vascular Injury. 査読 国際誌

    Sou Otuki, Daisuke Izumi, Masayoshi Suda, Akinori Sato, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Ichiro Fuse, Tohru Minamino

    Journal of the American College of Cardiology   71 ( 1 )   102 - 104   2018年1月

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  • Inappropriate inhibition of biventricular pacing due to diaphragmatic myopotentials amplified by the selectable sensing filter 査読

    Kenichi Iijima, Naoko Ishida, Daisuke Izumi, Tohru Minamino

    EUROPACE   19 ( 12 )   2014 - 2014   2017年12月

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    記述言語:英語   出版者・発行元:OXFORD UNIV PRESS  

    DOI: 10.1093/europace/euw372

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  • The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias 査読

    Sou Otuki, Kanae Hasegawa, Hiroshi Watanabe, Goro Katsuumi, Nobue Yagihara, Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Furushima, Masaomi Chinushi, Yoshifusa Aizawa, Tohru Minamino

    JOURNAL OF ELECTROCARDIOLOGY   50 ( 3 )   277 - 281   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    Background: Patients with repetitive ventricular tachyarrhythmias so-called electrical storm frequently require antiarrhythmic drugs. Amiodarone is widely used for the treatment of electrical storm but is ineffective in some patients. Therefore, we investigated the efficacy of stepwise administration of nifekalant, a pure potassium channel blocker, and mexiletine for electrical storm.
    Methods: This study included 44 patients with repetitive ventricular tachyarrhythmias who received stepwise therapy with nifekalant and mexiletine for electrical storm. Nifekalant was initially administered, and mexiletine was subsequently added if nifekalant failed to control ventricular tachyarrhythmias.
    Results: Nifekalant completely suppressed recurrences of ventricular arrhythmias in 28 patients (64%), including 6 patients in whom oral amiodarone failed to control arrhythmias. In 9 of 16 patients in whom nifekalant was partially effective but failed to suppress ventricular arrhythmias, mexiletine was added. The addition of mexiletine prevented recurrences of ventricular tachyarrhythmias in 5 of these 9 patients (56%). There was no death associated with electrical storm. In total, the stepwise treatment with nifekalant and mexiletine was effective in preventing ventricular tachyarrhythmias in 33 of 44 patients (75%). There was no difference in cycle length of the ventricular tachycardia, QRS interval, QT interval, or left ventricular ejection fraction between patients who responded to antiarrhythmic drugs and those who did not. During follow-up, 8 patients had repetitive ventricular tachyarrhythmia recurrences, and the stepwise treatment was effective in 6 of these 8 patients (75%).
    Conclusions: The stepwise treatment with nifekalant and mexiletine was highly effective in the suppression of electrical storm. (C) 2016 Published by Elsevier Inc.

    DOI: 10.1016/j.jelectrocard.2016.09.005

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  • Malignant Form of Idiopathic Ventricular Arrhythmia Originating from the Right Ventricular Outflow Tract 査読

    Keiko Sonoda, Hiroshi Watanabe, Masaomi Chinushi, Kanae Hasegawa, Nobue Yagihara, Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Furushima, Yoshifusa Aizawa

    journal of arrhythmia   27 ( 4 )   316   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Idiopathic ventricular fibrillation (VF) and/or polymorphic VT are occasionally initiated by VT or premature ventricular contraction (PVC) originating from the RVOT. Methods: Among 56 patients without structural heart disease in whom EPS was conducted for idiopathic VT arising from the RVOT, we examined the clinical characteristics in 5 patients with VF or polymorphic VT initiated by PVC originating from RVOT. Results: Episodes of VF were documented in 1 patient and polymorphic VT in 4 patients including one with a family history of aborted sudden death. In holter recording, there was no PVC/VT with short coupling interval in any patients. In Treadmill test, there were no patient with VT/VF inducted by exercise. 2 patients had J waves. The morphologies of PVC triggering polymorphic VT or VF were various:QS pattern was seen in the lead? in 3 patients, RS pattern was seen in the remaining. Conclusion: In this study, we found that the lack of inducibility by exercise and the absence of family history of cardiac disease were not always benign factor in the RVOT-VT/PVC. There were not any special feature in the form of PVC triggering VT/VF. Our findings may be useful to treat the patients with history of syncope and episodes of RVOT VT/VPC. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI: 10.4020/jhrs.27.PJ2_085

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  • Electrical stimulation-based evaluation for functional modification of renal autonomic nerve activities induced by catheter ablation 査読

    Masaomi Chinushi, Katsuya Suzuki, Osamu Saitoh, Hiroshi Furushima, Kenichi Iijima, Daisuke Izumi, Akinori Sato, Mika Sugai, Mitsuya Iwafuchi

    HEART RHYTHM   13 ( 8 )   1707 - 1715   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND Catheter ablation of the renal artery can be performed without apparent angiographic stenosis. This suggests that renal nerve function can be attenuated with minor structural damage to the renal artery.
    OBJECTIVE To clarify this hypothesis, we examined the relationship between electrical nerve stimulation (ENS)-induced blood pressure (BP) response and severity of histological injury of the renal artery using an acute canine model of renal artery ablation.
    METHODS An irrigation catheter was inserted into the renal arteries of 8 dogs, and radiofrequency current was delivered at 15, 20, or 25 W. ENS was applied to each artery before and after ablation.
    RESULTS Before ablation, ENS increased the BP and heart rate from 145 15/86 13 to 189 21/111 19 mm Hg and from 116 9 to 130 6 beats/min, respectively. Heart rate variability indices and serum catecholamine levels were elevated concomitantly. After ablation, the ENS -induced increase in BP and heart rate were markedly attenuated after 15 W ablation and those were nearly completely inhibited after 20 or 25 W ablation. An increase in heart rate variability indices and serum catecholamine levels became insignificant regardless of the applied energy. Renal artery angiograms revealed stenotic lesions only after 25 W ablation procedures. Histological studies showed mild to moderate injury of the arterial wall and autonomic nerves caused by 20 and 25 W ablation procedures, whereas only minor changes caused by 15 W ablation.
    CONCLUSION Functional renal autonomic nerve ablation is potentially performable with the guidance of ENS.

    DOI: 10.1016/j.hrthm.2016.04.021

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  • 血圧調整における左右腎交感神経興奮の役割 (実験モデルの神経電気刺激と高周波アブレーション)

    池主 雅臣, 鈴木 克弥, 齋藤 修, 大矢 佳奈, 飯嶋 賢一, 佐藤 光希, 和泉 大輔, 須貝 美佳, 古嶋 博司

    心臓   48 ( 6 )   608 - 616   2016年6月

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    記述言語:日本語   出版者・発行元:公益財団法人 日本心臓財団  

    腎動脈アブレーションでは両側腎動脈に高周波通電が行われているが, その根拠は明らかにされていない. 高周波通電が両側腎動脈に行われる理由を検証するため動物実験を行った. ビーグル犬を用いて血圧調整における左右腎交感神経興奮の効果を, 腎動脈高周波アブレーション前後の神経電気刺激の昇圧反応から検討した. 腎動脈にイリゲーションカテーテルを挿入して高周波通電を片側腎動脈に行い, 先端電極からの神経電気刺激をアブレーション前後で施行した. アブレーション前の神経電気刺激で昇圧速脈反応が左右腎動脈で同程度に誘発され, 心拍変動解析の交感神経指標と血中カテコラミン値も上昇した. アブレーションを施行した腎動脈では神経電気刺激による昇圧速脈反応は観察されなくなったが, アブレーションをしなかった腎動脈の神経電気刺激では, アブレーション前と同等の昇圧速脈反応が再度誘発された. 腎交感神経刺激による全身交感神経緊張は左右腎動脈で同等に生じ, 一側腎動脈アブレーションは, 対側腎動脈刺激の昇圧速脈誘発に影響を与えなかった. 腎動脈アブレーションで成果を得るには, 両側腎動脈通電が望まれることを支持する所見と思われる.</p>

    DOI: 10.11281/shinzo.48.608

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  • Effects of combination therapy with nifekalant and mexiletine on electrical storm 査読

    Otuki S, Hasegawa K, Watanabe H, Yagihara N, Iijima K, Sato A, Izumi D, Furushima H, Chinushi M, Minamino T

    EUROPEAN HEART JOURNAL   36   1068   2015年8月

  • Frequency Characteristics and Associations with the Defibrillation Threshold of Ventricular Fibrillation in Patients with Implantable Cardioverter Defibrillators 査読

    Kenichi Iijima, Masaomi Chinushi, Osamu Saitoh, Kanae Hasegawa, Keiko Sonoda, Nobue Yagihara, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Hiroshi Furushima, Yoshifusa Aizawa, Tohru Minamino

    INTERNAL MEDICINE   54 ( 10 )   1175 - 1182   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Objective The dominant frequency (DF) in frequency analyses is considered to represent the objective cycle length and complexity of activation under conditions of ventricular fibrillation (VF). However, knowledge regarding the mechanisms determining the DF in human VF is limited. We studied the characteristics of the DF of human VF and relationship between DF and the defibrillation threshold.
    Methods Seventy-two implantable cardioverter-defibrillator patients and 211 VF were studied. Using defibrillation tests, we performed a frequency analysis with fast Fourier transformation. The correlations between DF and clinical characteristics, including the defibrillation threshold, were assessed.
    Results The mean DF of all induced VFs was 5.2 +/- 0.8 Hz. The patients were divided into two groups according to DF: the low-DF (DF <5.2 Hz, n=32) and high-DF (DF >= 5.2 Hz, n=40) groups. The frequency of structural heart disease was significantly higher in the low-DF group. In addition, the QRS duration, QT interval and effective refractory period of the right ventricle (RV-ERP) were significantly longer in the low-DF group. A multivariate analysis showed RV-ERP to be the only independent predictor of DF. Excluding patients receiving group III anti-arrhythmic drugs, which are known to have potent defibrillation threshold effects, the defibrillation threshold was significantly lower in the low-DF group (p=0.026).
    Conclusion We found that the DF of human VF is associated with underlying heart disease, the cardiac function, cardiac conduction, ventricular refractoriness and defibrillation threshold. Our findings may be useful for identifying and managing patients with a high defibrillation threshold.

    DOI: 10.2169/internalmedicine.54.3113

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  • 下顎骨骨折の周術期にブルガダ症候群と診断された1例

    大貫 尚志, 児玉 泰光, 黒川 亮, 嵐山 貴徳, 永井 孝宏, 和泉 大輔, 高木 律男

    口腔顎顔面外傷   12 ( 2 )   109 - 114   2014年5月

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    記述言語:日本語   出版者・発行元:日本口腔顎顔面外傷学会  

    29歳男。意識消失後に転倒して受傷し救急搬送された。オトガイ部に裂傷、左側顎関節周囲に腫脹・疼痛あり、上下顎切歯間に開口障害を認め、パノラマX線およびCT所見より下顎多発骨折(左側下顎頭部骨折、#31-#37部・#41-#43部骨体部骨折)と診断した。ゴム牽引による咬合整復、顎間固定、左側下顎頭骨折に対し保存的加療を行い、下顎骨骨体部骨折に対しては観血的整復固定術を行うこととし全身精査を行った。12誘導心電図検査にて胸部誘導V3でST上昇、完全右脚ブロックを認めたため循環器内科での精査となり、薬物負荷心電図における胸部誘導V1、V2、V3にて典型的なcoved型心電図を認めブルガダ症候群と診断された。下顎骨観血的整復固定術を行った後に循環器内科に転科し、心臓電気生理検査で誘発される心室細動を認めること、失神の既往を有し、突然死の家族歴がないことから不整脈の非薬物治療ガイドラインのクラスIIaと分類されICD植え込みの適応となった。しかし、患者の職場が磁場発生環境にあるためICD植え込みは未施行である。

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  • Augmentation of the J wave by rapid pacing in a patient with vasospastic angina 査読

    Akinori Sato, Hiroshi Watanabe, Keiko Sonoda, Masaomi Chinushi, Takashi Tsuda, Daisuke Izumi, Hiroshi Furushima, Tohru Minamino

    INTERNATIONAL JOURNAL OF CARDIOLOGY   172 ( 1 )   E111 - E113   2014年3月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.ijcard.2013.12.121

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  • Suppression of Storms of Ventricular Tachycardia by Epicardial Ablation of Isolated Delayed Potential in Noncompaction Cardiomyopathy 査読

    Masaomi Chinushi, Kenichi Iijima, Hiroshi Furushima, Daisuke Izumi, Akinori Sato, Nobue Yagihara, Kanae Hasegawa, Hiroshi Watanabe, Kyoko Soejima, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   36 ( 4 )   e115 - e119   2013年4月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    A 65-year-old recipient of an implantable cardioverter defibrillator suffering from ventricular noncompaction developed storms of ventricular tachycardia (VT). Epicardial voltage mapping revealed the presence of a large low-voltage area in the left ventricular apical and inferoposterior wall, and isolated delayed potential was recorded over 1.5 cm in the posterior border between low and normal myocardial voltage. Pacemapping at the delayed potential recording site produced two different QRS depending on pacing output strength, and these two QRS morphologies were similar to clinically documented VTs. During one of the VTs, a mid-diastolic potential was recorded from the site with the delayed potential, and rapid pacing produced concealed entrainment. After epicardial radiofrequency ablation of the isolated delayed potential, VTs were noninducible and the VT storm was suppressed. (PACE 2013; 36:e115-e119)

    DOI: 10.1111/j.1540-8159.2010.02999.x

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  • Blood pressure and autonomic responses to electrical stimulation of the renal arterial nerves before and after ablation of the renal artery 査読

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Katsuya Suzuki, Hiroshi Furushima, Osamu Saitoh, Yui Furuta, Yoshifusa Aizawa, Mitsuya Iwafuchi

    Hypertension   61 ( 2 )   450 - 456   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Radiofrequency (RF) catheter ablation of the renal artery is therapeutic in patients with drug-refractory essential hypertension. This study was designed to examine the role of the renal autonomic nerves and of RF application from inside the renal artery in the regulation of blood pressure (BP). An open irrigation catheter was inserted into either the left or right renal artery in 8 dogs. RF current (17±2 watts) was delivered to one renal artery. Electrical autonomic nerve stimulation was applied to each renal artery before and after RF ablation. BP, heart rate, indices of heart rate variability, and serum catecholamines were analyzed. Before RF ablation, electrical autonomic nerve stimulation of either renal artery increased BP from 150±16/ 92±15 to 173±21/105±16 mm Hg. After RF ablation, BP increased similarly when the nonablated renal artery was electrically stimulated, although the rise in BP was attenuated when the ablated renal artery was stimulated. Serum catecholamines and sympathetic nerve indices of heart rate variability increased when electrical autonomic nerve stimulation was applied before RF ablation and to the nonablated renal artery after RF ablation, although it changed minimally when the ablated renal artery was stimulated, suggesting interconnectivity between afferent renal nerve stimulation and systemic sympathetic activity. Renal artery angiogram showed no apparent injury after RF ablation. In conclusion, electrical stimulation of the renal arterial autonomic nerves increases BP via an increase in central sympathetic nervous activity. This response might be used to determine the target ablation site and end point of renal artery RF ablation. © 2012 American Heart Association, Inc.

    DOI: 10.1161/HYPERTENSIONAHA.111.00095

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  • Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead 査読

    Akinori Sato, Masaomi Chinushi, Daisuke Izumi, Hiroshi Furushima, Tohru Minamino

    Internal Medicine   52 ( 11 )   1189 - 1193   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In two patients treated with cardiac resynchronization therapy (CRT), left ventricular (LV) pacing failure occurred due to ring conductor fractures of the bipolar LV lead (co-radial model). CRT was resumed by pacing between the tip conductor of the LV lead and the coil conductor of the right ventricular lead. However, shortly thereafter, subsequent fracture of the tip conductor developed, and implantation of a new LV lead was required. When one of the bipolar conductors of a co-radial designed LV lead fractures, reimplantation of a new LV lead is a better therapeutic option (than changing the LV pacing mode) in order to reliably continue CRT treatment. © 2013 The Japanese Society of Internal Medicine.

    DOI: 10.2169/internalmedicine.52.8988

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  • Correlation between Defibrillation Threshold and Dominant Frequency of Ventricular Fibrillation 査読

    Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Hiroshi Furushima, Masaomi Chinushi

    CIRCULATION   126 ( 21 )   2012年11月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Radiofrequency Catheter Ablation to Ventricular Tachycardia with Tetoralogy of Fallot Usefulness of Ablation to Narrow Channel of Macroreentrant Circuit Around Ventricular Septal Patch 査読

    Hiroshi Furushima, Masaomi Chinushi, Hiroshi Watanabe, Daisuke Izumi, Akinori Sato, Kenichi Iijima

    CIRCULATION   126 ( 21 )   2012年11月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Hemodynamic Responses and Histological Effects of Radiofrequency Catheter Ablation to Renal Artery Sympathetic Nerve 査読

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Katuya Suzuki, Hiroshi Furushima, Yoshifusa Aizawa, Mitsuya Iwafuchi

    CIRCULATION   126 ( 21 )   2012年11月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Nifekalant Enlarged the Transmural Activation-Recovery Interval Difference as Well as the Peak-to-End Interval on Surface ECG in a Patient with Short-QT Syndrome 査読

    Masaomi Chinushi, Akinori Sato, Daisuke Izumi, Hiroshi Furushima

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   23 ( 8 )   877 - 880   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Transmural ARI Dispersion in SQTS. A 38-year-old woman with type 1 short-QT syndrome (SQTS) was referred to our hospital. Her ECG showed short QT/QTc interval and peaked T wave. Activationrecovery intervals (ARIs) were calculated from the intracardiac endocardial and epicardial electrode catheters placed in the left ventricle (LV). Intravenous administration of nifekalant prolonged effective refractory period at multiple ventricular sites as well as the QT/QTc interval (from 260/300 to 364/419 ms) on the surface ECG. Nifekalant also enlarged the transmural ARI dispersion of the ventricular repolarization, which was measured by the difference between the longest endocardial ARI and the shortest epicardial ARI during atrial pacing at 90 bpm, from 73 to 103105 ms. These values corresponded to the intervals between the peak and end of the T wave on the surface ECG. Nifekalant-induced QT interval prolongation on the surface ECG may not indicate attenuation of the arrhythmogenic potential in the heart of SQTS patients. (J Cardiovasc Electrophysiol, Vol. 23, pp. 877-880, August 2012)

    DOI: 10.1111/j.1540-8167.2012.02292.x

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  • Exercise-Related QT Interval Shortening with a Peaked T Wave in a Healthy Boy with a Family History of Sudden Cardiac Death 査読

    Masaomi Chinushi, Akinori Sato, Kenichi Iijima, Katuya Suzuki, Furushima Hiroshi, Daisuke Izumi, Hiroshi Watanabe, Hasegawa Kanae, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   35 ( 8 )   e239 - e242   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    An asymptomatic 15-year-old boy, who had a family history of sudden cardiac death, was referred for screening for cardiac disease. The 12-lead electrocardiogram at rest showed a short QT/QTc(Bazett)/QTc(Fredericia) interval of 320/388/364 ms, but the intervals were further shortened to 200/339/284 ms after the treadmill test concomitant with appearance of a peaked T wave. Other conventional cardiac examinations were normal, but effective refractory period was less than 180 ms in both ventricles, and double ventricular extrastimulation reproducibly induced nonsustained polymorphic ventricular tachycardia. Intravenous administration of epinephrine also induced a short QT interval and a peaked T wave, and a hump was manifested on the T wave of the first postpacing beat with a longer preceding RR interval. Furthermore, a couple of premature ventricular complexes originated from a similar timing as the hump. Genetic analysis did not show the mutation in KCNQ1, KCNH2, KCNE1, KCNE2, KCNJ2, SCN5A genes but revealed single nucleotide polymorphism (C5457T) in SCN5A gene. (PACE 2012; 35:e239e242)

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  • Characteristics of J Wave-Associated Idiopathic Ventricular Fibrillation: Role of Drugs 査読

    Masaomi Chinushi, Kanae Hasegawa, Kenichi Iijima, Hiroshi Furushima, Daisuke Izumi, Akinori Sato, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   35 ( 8 )   e226 - e230   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    A storm of J wave-associated idiopathic ventricular fibrillation (VF) was observed in a 49-year-old man. Multiform premature ventricular complexes initiated the episodes of VF. Intravenous isoproterenol attenuated the J wave and suppressed the VF storm. After the implantation of a cardioverter defibrillator, VF was induced by programmed electrical stimulation at baseline, and it was terminated by a 25-J shock after an unsuccessful 15-J shock. During oral treatment with quinidine sulfate, 600 mg daily, the J wave was attenuated and VF became noninducible by programmed electrical stimulation. VF induced by a shock delivered on the T wave was terminated by a single 10-J shock. Mean F-F interval and dominant frequency of the VF were 162 ms and 6.8 Hz at baseline, and 210 ms and 5.0 Hz during the quinidine sulfate treatment. (PACE 2012; 35:e226e230)

    DOI: 10.1111/j.1540-8159.2011.03066.x

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  • Analysis of J waves during myocardial ischaemia 査読

    Akinori Sato, Yasuhiko Tanabe, Masaomi Chinushi, Yuka Hayashi, Tsuyoshi Yoshida, Eiichi Ito, Daisuke Izumi, Kenichi Iijima, Nobue Yagihara, Hiroshi Watanabe, Hiroshi Furushima, Yoshifusa Aizawa

    EUROPACE   14 ( 5 )   715 - 723   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    The aim of this study was to investigate the relationship between J-wave dynamics and arrhythmias during myocardial ischaemia in patients with vasospastic angina (VSA).
    Sixty-seven consecutive patients diagnosed with VSA by a provocation test for coronary spasm were grouped according to whether they had a J wave in the baseline electrocardiograms or not (VSA-JW group, n 14; VSA-non-JW group: n 53). We retrospectively studied the associations between J-wave and ST-segment dynamics and induced ventricular fibrillations (VFs) during coronary spasm. In the VSA-JW group, 7 of the 14 patients showed changes in J-wave morphology and/or gains in J-wave voltage, followed by VF in 4 patients. Compared with patients without VF, the four patients with VF showed similar maximal voltage in the baseline J waves but a higher voltage during induced coronary spasms (0.57 0.49 vs. 0.30 0.11 mV; P 0.011). In three patients with VF, J waves progressively increased and were accompanied by the characteristic coved-type or lambda-shaped ST-segment elevations. In the VSA-non-JW group, only four patients showed new appearances of J waves during coronary spasms and another patient without a distinct J wave developed VF. Ventricular fibrillations were induced more frequently in the VSA-JW group than in the VSA-non-JW group [4/14 (29) vs. 1/53 (2); P 0.012].
    J-wave augmentations were caused by myocardial ischaemia during coronary spasms. The presence and augmentation of J waves, especially prominent J waves with the characteristic ST-elevation patterns, were associated with VF.

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  • Is the coexistence of sustained ST-segment elevation and abnormal Q waves a risk factor for electrical storm in implanted cardioverter defibrillator patients with structural heart diseases? 査読

    Hiroshi Furushima, Masaomi Chinushi, Kenichi Iijima, Kanae Hasegawa, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Yoshifusa Aizawa

    EUROPACE   14 ( 5 )   675 - 681   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    The aim of this study was to determine whether or not the coexistence of sustained ST-segment elevation and abnormal Q waves (STe-Q) could be a risk factor for electrical storm (ES) in implanted cardioverter defibrillator (ICD) patients with structural heart diseases.
    In all, 156 consecutive patients received ICD therapy for secondary prevention of sudden cardiac death and/or sustained ventricular tachyarrhythmias were included. Electrical storm was defined as epsilon 3 separate episodes of ventricular tachycardia (VT) and/or ventricular fibrillation (VF) terminated by ICD therapies within 24 h. During a mean follow-up of 1825 1188 days, 42 (26.9) patients experienced ES, of whom 12 had coronary artery disease, 15 had idiopathic dilated cardiomyopathy, 6 had hypertrophic cardiomyopathy, 4 had arrhythmogenic right ventricular cardiomyopathy, 4 had cardiac sarcoidosis, and 1 had valvular heart disease. Sustained ST-segment elevation and abnormal Q waves in epsilon 2 leads on the 12-lead electrocardiography was observed in 33 (21) patients. On the KaplanMeier analysis, patients with STe-Q had a markedly higher risk of ES than those without STe-Q (P 0.0001). The multivariate Cox proportional hazards regression model indicated that STe-Q and left ventricular ejection fraction (LVEF) (30) were independent risk factors associated with the recurrence of VT/VF (STe-Q: HR 1.962, 95 CI 1.243.12, P 0.004; LVEF: HR 1.860, 95 CI 1.202.89, P 0.006), and STe-Q was an independent risk factor associated with ES (HR 4.955, 95 CI 2.699.13, P 0.0001).
    Sustained ST-segment elevation and abnormal Q waves could be a risk factor of not only recurrent VT/VF but also ES in patients with structural heart diseases.

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  • The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather than transmural dispersion of ventricular repolarization in an anthopleurin-A model of prolonged QT interval 査読

    Daisuke Izumi, Masaomi Chinushi, Kenichi Iijima, Hiroshi Furushima, Yukio Hosaka, Kanae Hasegawa, Yoshifusa Aizawa

    HEART RHYTHM   9 ( 5 )   796 - 803   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND Previous studies have showed that the interval between the peak and the end of the T wave (Tp-e) is a marker of transmural dispersion of ventricular repolarization.
    OBJECTIVE We studied the relationship between (a) the Tp-e on local pseudo transmural electrograms (pseudo transmural Tp-e) or limb leads of body surface electrocardiogram (surface Tp-e) and (b) the intracardiac left ventricular (LV) repolarization during a drug-induced QT-interval prolongation.
    METHODS Using open-chested canine intact hearts treated by anthopleurin-A, transmural LV electrograms were recorded via needle electrodes placed in the basoanterior, midanterior, apicoanterior, basolateral, midlateral, and apicolateral LV wall. Recovery time (RT) was calculated as an index of local repolarization at each transmural unipolar electrode.
    RESULTS This model showed slower heart rate-dependent heterogeneous distribution of ventricular repolarization both along the basal to apical axis and along the transmural axis. RT was longer at the LV apex than at the base and longer in the lateral than in the anterior wall during the slower heart rate. A high correlation was found between surface Tp-e and total LV dispersion. In contrast, pseudo transmural Tp-e correlated with transmural RT dispersion. The shortest RT in the heart roughly corresponded to the peak, as did the longest RT with the end of the T wave on the surface electrocardiogram.
    CONCLUSION During drug-induced QT-interval prolongation with a large apicobasal and anterolateral dispersion of ventricular repolarization, the Tp-e in the limb leads expresses spatial (total) distribution of repolarization in the whole left ventricle.

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  • Epicardial Scar in a Patient with no Apparent Heart Disease 査読

    Masaomi Chinushi, Daisuke Izumi, Hiroshi Furushima, Akinori Sato, Kenichi Iijima, Kanae Hasegawa, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   35 ( 5 )   e136 - e139   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    A 35-year-old man, who had an episode of aborted sudden cardiac death due to ventricular fibrillation, suffered from multiple storms of ventricular tachycardia (VT). Conventional cardiac examinations did not reveal any structural heart diseases, and he had been treated by an implantable cardioverter defibrillator since 2007. At the latest admission, epicardial but not endocardial voltage mapping revealed a small area of low voltage at the left ventricular (LV) postero-lateral wall where a delayed potential was recorded during sinus rhythm. Excellent pacemapping with a prolonged stimulus to QRS interval was obtained from the area, and a mid-diastolic potential was recorded during the VT. Radiofrequency application terminated the VT and any VT became noninducible after the ablation. In some patients diagnosed as LV-VT with no apparent heart disease, arrhythmogenic substrate may exist on the epicardial surface of the ventricle. (PACE 2012; 35:e136e139)

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  • Relationship between electroanatomical voltage mapping characteristics and breakout site of ventricular activation in idiopathic ventricular tachyarrhythmia originating from the right ventricular outflow tract septum 査読

    Hiroshi Furushima, Masaomi Chinushi, Kenichi Iijima, Daisuke Izumi, Yukio Hosaka, Yoshifusa Aizawa

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   33 ( 2 )   135 - 141   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Objective To assess the electrophysiological characteristics of the breakout site of ventricular activation using electroanatomical voltage mapping (EVM) and its relation to the optimal ablation site in idiopathic ventricular tachyarrhythmias originating from the outflow tract of the (RVOT) septum.
    Methods Twenty-eight patients with symptomatic drug-refractory premature ventricular complexes (PVCs) and/or ventricular tachycardia (VT) originating from the RVOT septum and 5 control subjects with WPW syndrome were included. Low-voltage areas (LVAs) were defined as signal amplitudes between 0.1 and 1.5 mV. The borderline between the normal area and the LVA was defined as "border," and the distance from the LVA to the border (length of LVA) was measured.
    Results In all 28 patients and control subjects, there was an LVA below the pulmonary valve. There was no significant difference in length of LVA between patients with idiopathic ventricular arrhythmias and control subjects (2.0+/-0.6 vs. 1.9+/-0.1 cm). In 19 of the 28 patients, the optimal ablation site was identical to the border area. In all 11 patients who had pre-potentials at the successful ablation site, there were two cases with polymorphic VT and/or ventricular fibrillation associated with PVCs. In these two cases, length of LVA was longer than in other patients (4.0 and 3.9 cm vs. 1.8+/-0.5 cm (n=26)), and the optimal ablation site was located at the border area.
    Conclusion The border area, including the LVA, tends to be the breakout site and/or origin of ventricular arrhythmias in idiopathic ventricular tachyarrhythmia originating from the RVOT septum.

    DOI: 10.1007/s10840-011-9623-8

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  • The prevalence of early repolarization in Wolff-Parkinson-White syndrome with a special reference to J waves and the effects of catheter ablation 査読

    Nobue Yagihara, Akinori Sato, Kenichi Iijima, Daisuke Izumi, Hiroshi Furushima, Hiroshi Watanabe, Tadanobu Irie, Yoshiaki Kaneko, Masahiko Kurabayashi, Masaomi Chinushi, Masahito Satou, Yoshifusa Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   45 ( 1 )   36 - 42   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    We determined the prevalence of J waves in the electrocardiograms (ECG) of 120 patients with Wolff-Parkinson-White syndrome in comparison with J-wave prevalence in a control group of 1936 men and women with comparable demographic and ECG characteristics and with normal atrioventricular conduction. J waves were present only during manifest preexcitation in 22 of 120 patients (18.3%), disappearing after catheter ablation and suggesting that J waves were associated with the presence of preexcitation. J waves were present in 19 (15.8%) of 120 patients only after ablation, apparently having been masked by early depolarization of the preexcited myocardial region, and in 22 patients (18.3%), J waves were not altered significantly by preexcitation. Thus, the overall J-wave prevalence was 52.5% (63/120) and, excluding those apparently due to preexcitation, 34.8% (41/120), both substantially higher than the prevalence (11.5%) in the control group (P < .001 for both). The patients with J waves appearing only during preexcitation were younger, predominantly females. The presence of J waves after ablation was associated with a history of atrial fibrillation and shorter ventricular effective refractory period. It is concluded that the prevalence of J waves is high in patients with Wolff-Parkinson-White syndrome and is influenced by manifest preexcitation. (C) 2012 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.jelectrocard.2011.04.006

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  • Benign Premature Ventricular Complexes from the Right Ventricular Outflow Tract Triggered Polymorphic Ventricular Tachycardia in a Latent Type 2 LQTS Patient 査読

    Akinori Sato, Masaomi Chinushi, Keiko Sonoda, Akira Abe, Daisuke Izumi, Hiroshi Furushima

    INTERNAL MEDICINE   51 ( 23 )   3261 - 3265   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    A 57-year-old woman showed frequent premature ventricular complexes (PVCs) originating from the right ventricular outflow tract (RVOT), and some of the PVCs triggered polymorphic ventricular tachycardia (PVT). Structural heart diseases were ruled out by conventional cardiac examinations. Radiofrequency catheter ablation was successful in eliminating the PVCs and subsequent PVT. However, epinephrine infusion unmasked her prolonged QT interval, and a genetic analysis revealed a KCNH2 mutation (R694H) as the cause of latent type-2 long QT syndrome (LQTS). This case suggests that latent LQTS may work as an arrhythmogenic substrate of PVT triggered by a benign form of RVOT-PVCs in patients with a structurally normal heart.

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  • Insulation Defects in Riata Implantable Cardioverter-defibrillator Leads 査読

    Akinori Sato, Masaomi Chinushi, Kenichi Iijima, Daisuke Izumi, Hiroshi Furushima

    INTERNAL MEDICINE   51 ( 19 )   2689 - 2694   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Background The structures composing implantable cardioverter-defibrillator (ICD) leads have become more complicated and thinner with technological advances. Silicon insulation defects with and without clinically manifested electrical abnormalities have been reported in Riata leads (St. Jude Medical).
    Objective The aim of this study was to assess the incidence and clinical implications of insulation defects in Riata leads implanted at our hospital.
    Methods The subjects included 10 consecutive patients who received 8-French Riata ICD leads with dual-coil conductors (model 1580 or 1581) between 2006 and 2010 at our hospital. Operative records, chest X-rays and interrogation data were reviewed.
    Results In all cases, Atlas+ (St. Jude Medical) was used as an ICD generator and the Riata leads were implanted transvenously and fixed to the right ventricular apex. During a mean follow-up period of 52 +/- 9 (36-70) months, chest X-rays revealed insulation defects in Riata leads and conductor wires projecting from the bodies of the Riata leads in two of 10 (20%) patients. One of the patients received inappropriate ICD therapies due to T-wave oversensing based on attenuation of R waves and augmentation of T waves 41 months after implantation. In the other patient, an insulation defect without any clinically manifested electrical troubles was detected 50 months after implantation.
    Conclusion Riata leads have a high incidence of insulation defects, which may be occasionally accompanied by inappropriate ICD discharges. For patients with Riata leads, careful observation of any changes in the lead-electrical measurements and a routine chest X-ray follow-up are necessary.

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  • Ventricular Tachycardia Due to Intramyocardial Fibroma 査読

    Kenichi Iijima, Masaomi Chinushi, Daisuke Izumi, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   22 ( 7 )   825 - 826   2011年7月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/j.1540-8167.2010.01974.x

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  • Catheter Ablation of Ventricular Tachycardias Due to Forward and Reverse Propagation Across a Reentrant Circuit Inside a Nonischemic Biventricular Aneurysm 査読

    Masaomi Chinushi, Daisuke Izumi, Hiroshi Furushima, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   22 ( 4 )   467 - 471   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Ablation of Bidirectional VT. A 64-year-old recipient of implantable cardioverter defibrillator presenting with a 4.7 x 3.3 cm nonischemic, biventricular aneurysm developed multiple electrical storms due to ventricular tachycardia (VT) with 2 distinct QRS morphologies. Endocardial electroanatomical mapping revealed the presence of a low-voltage area corresponding to the aneurysm, where multiple delayed potentials were recorded. Activation mapping and entrainment pacing of both VT revealed the, respectively, forward and reverse propagation of the wavefront across a single reentrant circuit inside the ventricular aneurysm. Delivery of 3 applications of radiofrequency energy to a critical segment of the reentrant pathway eliminated both VT and the electrical storms. (J Cardiovasc Electrophysiol, Vol. 22, pp. 467-467).

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  • Transient left ventricular dysfunction associated with severe Legionella infection 査読

    Tomoyasu Suzuki, Masahiro Ito, Makoto Kodama, Wataru Mitsuma, Daisuke Izumi, Satoru Hirono, Go Hasegawa, Yoshifusa Aizawa

    Journal of Cardiology Cases   3 ( 2 )   e78 - e81   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Legionella infection, although commonly seen as pneumonia, can also manifest systemic involvement. Here, we describe a case of sporadic Legionella infection coinciding with pneumonia, rhabdomyolysis, renal failure, and severe left ventricular dysfunction, which subsequently developed refractory septic shock. An endomyocardial biopsy revealed no findings of interstitial inflammatory infiltrates. After 3 days of intensive care, including percutaneous cardiopulmonary support, intraaortic balloon pumping, and continuous hemodialysis with endotoxin adsorption therapy, left ventricular wall motion improved spontaneously in accordance with a decrease in the concentration of inflammatory cytokines. Cardiac complications are rare but Legionella infection should be considered as a possible etiology of left ventricular dysfunction in patients with sepsis. © 2011 Japanese College of Cardiology.

    DOI: 10.1016/j.jccase.2011.01.002

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  • Ventricular Fibrillation and Ventricular Tachycardia Triggered by Late-Coupled Ventricular Extrasystoles in a Brugada Syndrome Patient 査読

    Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Daisuke Izumi, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   34 ( 1 )   e1 - e5   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    Premature ventricular complexes (PVC) falling after the end of the T wave triggered ventricular fibrillation (VF) at night and monomorphic ventricular tachycardia (MVT) during daytime, in a recipient of implantable cardioverter defibrillator with Brugada syndrome. Treatment with bepridil (1) decreased the height of ST segment elevation in leads V1-V3, (2) completely eliminated VF, and (3) markedly decreased the incidence of PVC and MVT. Albeit rare, VF can be triggered by late-coupled PVC, due to a mechanism other than phase 2 reentry in some patients with Brugada syndrome. (PACE 2011; e1-e5).

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  • An Appropriate Defibrillation Threshold Obtained by the Combined Connection Between Two Shock Leads and ICD Generator 査読

    Akinori Sato, Masaomi Chinushi, Kenichi Iijima, Hiroshi Watanabe, Daisuke Izumi, Hiroshi Furushima, Keiko Sonoda, Kanae Hasegawa, Nobue Yagihara, Yoshifusa Aizawa

    INTERNAL MEDICINE   50 ( 22 )   2815 - 2818   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    A 60-year-old man with arrhythmogenic right ventricular cardiomyopathy was readmitted for the battery exchange of his implantable cardioverter-defibrillator (ICD). Since (i) he had been treated with a dual-coil shock lead (Sprint Fidelis, Medtronic) and (ii) pre-operative venography showed mild collateral flow to the left subclavian vein, a single-coil lead was additionally implanted. However, the single-coil defibrillation system was unable to terminate the induced ventricular fibrillation (VF), thus dual defibrillation shock pathways were created using the connection to the superior vena cava coil of the Fidelis lead. The combined connections of the two shock leads provided an appropriate margin of the defibrillation threshold.

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  • Inappropriate Pacing Inhibition Triggered by QT Prolongation due to T Wave Oversensing in an ICD Recipient Presenting with Long QT Syndrome 査読

    Kenichi Iijima, Masaomi Chinushi, Kanae Hasegawa, Daisuke Izumi, Yukio Hosaka, Hiroshi Furushima, Yoshifusa Aizawa

    INTERNAL MEDICINE   50 ( 9 )   1021 - 1024   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Inappropriate inhibition of atrial pacing due to T-wave oversensing (TWOS) was observed in a patient presenting with congenital long QT syndrome, treated with an implantable cardioverter defibrillator (ICD) and beta-adrenergic blocker. Development of TWOS was associated with further QT interval prolongation in the absence of amplitude changes in the intracardiac T and R waves. Replacement of the ICD generator with a sensing filter designed to attenuate the intracardiac T wave suppressed TWOS and normalized the pacing functions.

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  • Magnesium Treatment for Drug-Induced QT Prolongation 査読

    Daisuke Izumi, Masaomi Chinushi, Kenichi Lijima, Kanae Hasegawa, Akinori Sato, Hiroshi Furushima, Yoshifusa Aizawa

    journal of arrhythmia   27 ( 4 )   297   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Effects of magnesium administration (0.2ml/kg, iv) on the QT interval and transmural ventricular repolarization were compared among the 4 models of QT interval prolongation: (20 experiments) bepridil (BEP), amiodarone (AMD), E-4031 (E) or anthopleurin-A (AP-A). Using plunge needle electrodes, transmural electrograms were obtained from the left ventricle, and the activation-recovery interval (ARI) and transmural ARI-dispersion were analyzed. Results: (1) After administration of each drug, ARIs at all LV layers were prolonged, and transmural ARI-dispersions were enlarged in the AP-A and E models. BEP (4 mg/kg) homogeneously prolonged ARIs, and it produced a relatively small transmural ARI-dispersion (32±10 ms) similar to the AMD model (1.5 mg/kg/hr) (32±7 ms). (2) Magnesium injection (0.2 mEq/kg, iv) shortened ARIs and suppressed Torsades de Pointes in the AP-A model. (3) Magnesium did not shorten nor homogenize ARI distribution in the other 3 models. Magnesium slightly prolonged the ARIs in the E model. Conclusions: Magnesium did not reduce the transmural dispersion of repolarization except in AP-A model. Inhibition of the triggered premature beats seems to be another therapeutic effect of magnesium treatment for QT interval prolongation. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI: 10.4020/jhrs.27.PJ2_043

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  • Incidence and Management for Trouble-Shooting Associated with the Sprint-Fidelis ICD Lead 査読

    Kenichi Iijima, Masaomi Chinushi, Akinori Sato, Yukio Hosaka, Daisuke Izumi, Hiroshi Furushima, Hiroshi Watanabe, Masahito Sato, Katsuya Ebe, Hiroshi Shimizu, Kazuyoshi Takahashi, Yoshifusa Aizawa

    Journal of Arrhythmia   27   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Method: We investigated the outcomes of 136 patients with Sprint-Fidelis in 5 centers in Niigata Prefecture. Results. Incidence: Lead troubles occurred in 9 patients (6.6%). The mean period before the trouble was 31 months (16-57 months). Implantation: Among these 9 patients, the lead was implanted using a cut-down technique in 4, an extra-thoracic approach in 4 and a subclavian approach in 1. Discovery: The lead troubles in 5 were discovered at regular clinics. The other 4 patients emergently visited because of the lead integrity alert (LIA) or inappropriate ICD discharges. In the 9 patients, the average sensing integrity counter was 338/day and mean F-F interval, of which was recognized as NST, was less than 200ms. The LIA: The LIA had been programmed in 7, and 5 of the patients visited before inappropriate ICD discharges. However, the other 2 elderly patients couldn't notice the alert sound. Extraction: Lead extraction was attempted in 6 and 5 leads were removable without any complications. Conclusions: The incidence of troubles with Sprint-Fidelis is high, and it occurs in the relatively late phase. The LIA is useful to detect the lead problems but its efficacy may be limited in elderly patients. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI: 10.4020/jhrs.27.OP53_2

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  • Association of J-Wave with Atrial Fibrillation in Wolff-Parkinson-White Syndrome 査読

    Nobue Yagihara, Masaomi Chinushi, Hiroshi Furushima, Hiroshi Watanabe, Daisuke Izumi, Akinori Sato, Kenichi Iijima, Tadanori Irie, Yoshiaki Kaneko, Masahiko Kurabayashi, Masahito Sato, Yoshifusa Aizawal

    Journal of Arrhythmia   27   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: J-waves are considered to reflect early repolarization. We have previously reported the disappearance of J waves after catheter ablation of an accessory pathway in patients with Wolff-Parkinson-White syndrome. Here, we further studied the association of an accessory pathway on J-waves with Wolff-Parkinson-White syndrome. Methods: We included 124 patients with Wolff-Parkinson-White syndrome who underwent catheter ablation, and 1936 controls without structural heart disease or ECG abnormalities. Results: The prevalence of J-waves was higher in patients with Wolff-Parkinson-White syndrome (n=69, 56%) than the controls (n=222, 11.5%). After successful ablation of the Wolff-Parkinson-White patients, J-waves disappeared in 22 patients, while J-waves were still apparent or after ablation in 21 patients. The prevalence of atrial fibrillation was higher in patients with J-waves (n=31, 45%) after ablation than those without (n=15, 33%). The ventricular and atrial refractory period tended to be shorter in patients with J-waves, after ablation than those without such waves. Conclusion: J-waves were frequently observed and were affected by ablation of an accessory pathway in patients with Wolff-Parkinson-White syndrome although the exact nature of this association is still undetermined. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI: 10.4020/jhrs.27.OP52_3

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  • Characteristics of Ventricular Tachycardia in Drug-Refractory Electrical Storm in ICD Patients with Structural Heart Disease 査読

    Hiroshi Furushima, Masaomi Chinushi, Keiko Sonoda, Kanae Hasegawa, Nobue Yagihara, Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Yoshifusa Aizawa

    journal of arrhythmia   27   194   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective: The aim of the present study was to assess characteristics of ventricular tachycardia (VT) of electrical storm (ES) in ICD patients with structural heart disease. Methods: We included 156 consecutive patients who implanted ICD due to secondary prevention. ES was defined as the occurrence of at least 3 episodes of VT/VF within 24-hours. Basic treatment for ES was as follows
    sedation, β-blockers, and class I and/or III antiarrhythmic drugs. We defined that elimination of ES for 2 weeks after basic treatment was drug effective (DE), if not, drug refractory (DR). Results: During a mean follow-up period of 54 ± 37 months, ES occurred in 42 patients (OMI in 12, DCM in 15, HCM in 6, ARVC in 5, cardiac sarcoidosis in 4). Patients with DE and DR were 30 and 12 patients, respectively. There were no significant differences in age, sex, and LVEF. However, cycle length of VT (VTCL) was significantly longer in patients with DR than with DE (384 ± 16 vs. 305 ± 10 ms, p&lt
    0.05). All 12 patients with DE required for Catheter ablation. Conclusion: Longer VTCL in ES was related to drug refractoriness, which might be caused by stability of reentry circuit in spite of antiarrhythmic therapy. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI: 10.4020/jhrs.27.OP06_3

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  • Ventricular Tachyarrhythmia Associated with Hypertrophic Cardiomyopathy: Incidence, Prognosis, and Relation to Type of Hypertrophy 査読

    Hiroshi Furushima, Masaomi Chinushi, Kenichi Iijima, Akiko Sanada, Daisuke Izumi, Yukio Hosaka, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   21 ( 9 )   991 - 999   2010年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Patients: The study consisted of 66 consecutive patients with HCM who were admitted to Niigata University Hospital between 1992 and 2005. Their clinical characteristics and ECG morphology were investigated according to the type of HCM.
    Results: The type of HCM was asymmetric hypertrophy (ASH) in 34 patients (51%), obstructive HCM (HOCM) in 9 (14%), apical HCM (ApHCM) in 14 (21%), and midventricular obstruction (MVO) in 9 (14%). The cause of admission was ventricular tachyarrhythmia in 25 patients (38%), unexplained syncope in 11 (17%), and heart failure in 30 (45%). Sustained monomorphic ventricular tachycardia (SMVT) occurred in 19 patients and ventricular fibrillation in 6. In the 19 patients with SMVT, 12 had MVO and 3 of these had previous apHCM. Six of the 19 patients with SMVT had ASH, and 3 had abnormal apical wall motion. In 14 patients, the SMVT appeared to originate from the apical aneurysm based on the morphology of the tachycardia. Ventricular tachyarrhythmia recurred in 14 of the 25 patients (56%), and 4 of the 18 patients with an ICD had electrical storm. ASH with abnormal wall motion of the LV apex or MVO was recognized in the 4 patients with electrical storm; they commonly had abnormal Q waves and ST elevation in leads V4-V6.
    Conclusion: Ventricular tachyarrhythmia was responsible for 38% of hospitalizations in HCM, and SMVT occurred in patients with MVO and/or with abnormal wall motion of the LV apex. Electrical storm was more common in patients with ST elevation in precordial leads V4-V6. (J Cardiovasc Electrophysiol, Vol. 21, pp. 991-999, September 2010).

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  • Effects of Bepridil Versus E-4031 on Transmural Ventricular Repolarization and Inducibility of Ventricular Tachyarrhythmias in the Dog 査読

    Daisuke Izumi, Masaomi Chinushi, Kenichi Iijima, Shizue Ahara, Satoru Komura, Hiroshi Furushima, Yukio Hosaka, Akiko Sanada, Nobue Yagihara, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   33 ( 8 )   950 - 959   2010年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Methods: We used plunge needle electrode to record transmural left ventricular (LV) repolarization and activation-recovery interval (ARI) to estimate local repolarization. The correlation between paced cycle length and ARI was separately examined in the LV endocardium, mid-myocardium (Mid), and epicardium. Attempts to induce VTA were made during bradycardia and sympathetic stimulation.
    Results: Bepridil and E-4031 prolonged QT interval and ARI in all LV layers, though the magnitude of prolongation was greatest in Mid, increasing the transmural ARI dispersion, particularly during bradycardia. Compared with E-4031, bepridil caused mild, reverse use-dependent changes in ventricular repolarization, and less ARI dispersion than E-4031 during slow ventricular pacing. Both drugs increased ARI(max) and cycle length at 50% of ARI(max), though the changes were smaller after bepridil than after E-4031 administration. Bradycardia after the administration of each drug induced no VTA; however, sympathetic stimulation induced sustained polymorphic VTA in two of five dogs treated with E-4031 versus no dog treated with bepridil.
    Conclusions: Unlike the pure I(kr) blocker, E-4031, bepridil exhibited weak properties of reverse use-dependency and protected against sympathetic stimulation-induced VTA. It may be an effective supplemental treatment for recipients of implantable cardioverter defibrillator. (PACE 2010; 950-959).

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  • Effect of Bepridil in Atrial Fibrillation Inducibility Facilitated by Vagal Nerve Stimulation - Prevention of Vagal Nerve Activation-Induced Shortening of the Atrial Action Potential Duration 査読

    Kenichi Iijima, Masaomi Chinushi, Daisuke Izumi, Shizue Ahara, Hiroshi Furushima, Satoru Komura, Yukio Hosaka, Akiko Sanada, Akinori Sato, Yoshifusa Aizawa

    CIRCULATION JOURNAL   74 ( 5 )   895 - 902   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE CIRCULATION SOC  

    Background: Because bepridil blocks multiple myocardial ionic channels, including the muscarinic acetylcholine receptor-operated potassium current (I(KAch)), bepridil is expected to suppress atrial fibrillation (AF) mediated by vagal nerve stimulation (VNS).
    Methods and Results: The therapeutic effects of bepridil were studied with a special focus on heart rate variability (HRV) in a canine model of AF. During VNS, AF was induced in 9 of 9 experiments before, vs 3 of 9 experiments after administration of bepridil (P<0.01). During 350 ms atrial pacing, VNS shortened the right and left atrial monophasic action potentials at 90% repolarization (MAP90) by -31 +/- 8% and -22 +/- 12%, respectively, vs -10 +/- 13% and -6 +/- 8%, respectively, after bepridil (P<0.01, N=9). Bepridil prolonged the sinus cycle length, although it had no significant effect on the conduction time measured at 300 ms pacing. Statistically insignificant change was observed in the VNS-induced slowing of the sinus cycle length and in the VNS-induced increase in high frequency amplitude of HRV before (1.2 +/- 0.7 to 5.3 +/- 4.0 ms) vs after (1.7 +/- 0.8 to 5.4 +/- 2.3 ms) bepridil administration.
    Conclusions: Bepridil prevented the VNS-induced shortening of atrial MAP90 and suppressed the inducibility of AF during VNS in two-thirds of the experiments. As far as this study shows, it may be possible that inhibition of I(KAch) played a part in this antifibrillatory effect. (Circ J 2010; 74: 895-902)

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  • Efficacy of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia - Retrospective Case Series 査読

    Satoru Komura, Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Daisuke Izumi, Kenichi Iijima, Hiroshi Watanabe, Nobue Yagihara, Yoshifusa Aizawa

    CIRCULATION JOURNAL   74 ( 5 )   864 - 869   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE CIRCULATION SOC  

    Background: The efficacy of antiarrhythmic drugs in terminating sustained monomorphic ventricular tachycardia (SMVT) was assessed in a retrospective manner to provide a basis for recommending their use.
    Methods and Results: The 90 patients were included in this study to evaluate the efficacy to terminate SMVT using procainamide or lidocaine. All patients were alert and responsive. The mean systolic blood pressure was 91 +/- 25 mmHg (range, 40-150 mmHg). SMVT was diagnosed from ECG recordings and later in an electrophysiologic study. VTs with a cycle length of 329 +/- 55 and 324 +/- 61 ms were treated with the mean doses of 358 +/- 50 mg and 81 +/- 30 mg of procainamide and lidocaine and were terminated in 53/70 (75.7%) and in 7/20 (35.0%) respectively. The drugs were discontinued if there was no rise in blood pressure after slowing of the tachycardia rate or if there were signs of impending deterioration in consciousness. Though procainamide was effective, blood pressure was often low and DC shock should be available at all times during administration of the drug.
    Conclusions: Procainamide, the relatively older drug, was more effective than lidocaine in terminating SMVT associated with structural heart diseases. This is a retrospective analysis but can form the basis for formulating guidelines for initial management of SMVT. (Circ J 2010; 74: 864-869)

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  • Significance of Early Onset and Progressive Increase of Activation Delay During Premature Stimulation in Brugada Syndrome 査読

    Hiroshi Furushima, Masaomi Chinushi, Kenichi Iijima, Daisuke Izumi, Yukio Hosaka, Yoshifusa Aizawa

    CIRCULATION JOURNAL   73 ( 8 )   1408 - 1415   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE CIRCULATION SOC  

    Background: The relationship between the activation delay during programmed stimulation and the inducibility of ventricular fibrillation (VF) and filtered QRS duration on signal-averaged ECG (SAECG) were assessed in patients with Brugada syndrome (BS).
    Methods and Results: The activation delay was assessed using the interval between the stimulus and the QRS complex during programmed stimulation in 25 patients with BS and 10 with idiopathic ventricular tachycardia (controls). The mean increase of delay (MID) was used to characterize the conduction curves. The filtered QRS duration (fQRSd) in leads V(2) (RfQRSd) and V(5) (LfQRSd) were also evaluated using SAECG. Both MIDs at the right ventricular outflow tract (RVOT) were significantly greater in symptomatic and asymptomatic BS patients than in the control group (symptomatic, 7.1 +/- 2.7 ms vs control, 2.5 +/- 1.2 ms, P<0.001, asymptomatic, 7.3 +/- 3.3 ms vs control, P<0.001, respectively). The MID correlated with the His-ventricular interval; however, there were no significant correlations between the MID and RfQRSd or RfQRSd-LfQRSd.
    Conclusions: The MID, which indicates an increase of the St-QRS during premature stimulation, was much greater in patients with BS (regardless of clinical symptoms) than in the control group, especially in the RVOT, which might be related to the easy inducibility of VF from the RVOT. (Circ J 2009; 73: 1408-1415)

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  • Pilsicainide-Induced ST Segment Elevation and ST Segment Depression in Two Patients with Variant Forms of Brugada-Type Electrocardiographic Abnormalities 査読

    Masaomi Chinushi, Minoru Tagawa, Daisuke Izumi, Hiroshi Furushima, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   32 ( 6 )   811 - 815   2009年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    In two patients with variant forms of Brugada electrocardiographic abnormalities, ST segment elevation, and reciprocal ST segment depression developed during intravenous administration of pilsicainide. In one patient, pilsicainide accentuated the ST segment elevation in leads I, aV(L), and V(1)-V(3) and caused ST segment depression in leads II, III, and aV(F). Coronary angiograms at the time of ST segment elevation were normal. In the other patient, pilsicainide accentuated the coved-type ST segment elevation in leads II, III, and aV(F) and caused ST segment depression in leads I, aV(L), and V(2)-V(5). Frequent premature ventricular complexes (PVCs) with two different left bundle branch block patterns developed during ST segment elevation. Intravenous isoproterenol returned the ST segment to baseline in both patients and suppressed the PVCs in the second patient. We hypothesize that a wide area of epicardial myocardium with large I(to) current might explain the reciprocal ST segment depression observed at the time of accentuated ST segment elevation.
    (PACE 2009; 32:811-815).

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  • Ventricular Fibrillation Triggered during and after Radiofrequency Energy Delivery to the Site of Origin of Idiopathic Right Ventricular Outflow Tract Arrhythmia 査読

    Kenichi Iijima, Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Daisuke Izumi, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   32 ( 3 )   406 - 409   2009年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    We observed a case of idiopathic ventricular arrhythmias originating from the right ventricular outflow tract (RVOT). The origin of target premature ventricular contraction (PVC) and nonsustained ventricular tachycardia (VT) was within a wide low-voltage area around the RVOT. During radiofrequency (RF) application to the site of arrhythmia origin, polymorphic VT and ventricular fibrillation were repeatedly triggered by new PVC that had developed near the site of ablation. This electrical storm persisted > 30 minutes after cessation of RF current delivery, and was suppressed by additional RF applications to the site of origin of the new PVC.
    (PACE 2009; 32:406-409).

    DOI: 10.1111/j.1540-8159.2008.02253.x

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  • A post-QRS potential in Brugada syndrome its relation to electrocardiographic pattern and possible genesis 査読

    Yoshifusa Aizawa, Masaomi Chinushi, Minoru Tagawa, Hiroshi Furushima, Shinsuke Okada, Kenichi Iijima, Daisuke Izumi, Hiroshi Watanabe, Satoru Komura

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   51 ( 17 )   1720 - 1721   2008年4月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    DOI: 10.1016/j.jacc.2008.01.031

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  • Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome 査読

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Shizue Ahara, Satoru Komura, Hiroshi Furushima, Yukio Hosaka, Yoshifusa Aizawa

    EUROPACE   10 ( 2 )   249 - 255   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Aims The effects of adrenergic activity and beta-blockade were studied in a canine experimental model of type-3 tong QT syndrome (LQT3) induced by application of anthopleurin-A.
    Methods and results Boluses of epinephrine at 0.5 and/or 1.0 mu g/kg were administered before and after propranolol, 0.3 mg/kg, and the distribution of the ventricular repolarization and the development of polymorphic ventricular tachyarrhythmia (VA) were assessed. Using needle electrodes, transmural unipolar electrograms were recorded across the left ventricle (W) and right ventricle (RV). Activation-recovery interval (ARI) was measured in each electrogram to estimate local repolarization during RV pacing at the cycle length of 750 ms after the creation of complete atrioventricular block. Before propranolol, epinephrine, 0.5 mu g/kg, did not induce VA in any experiment. However, a dose of 1.0 mu g/kg induced polymorphic VA following multiple premature ventricular complex (PVC) in four of six experiments. Epinephrine, 0.5 mu g/kg, shortened ARI at all sites and lessened LV transmural ARI dispersion. Neither ARI nor its dispersion could be determined after 1.0 mu g/kg of epinephrine because of the induction of PVC, polymorphic VA, or both. Propranolol (i) prevented epinephrine-induced PVC and polymorphic VA in all experiments, (ii) slightly prolonged ARI at all sites, along with a decrease in IV transmural. ARI dispersion, and (iii) reversed the epinephrine-induced shortening of ARI.
    Conclusion In this LQT3 model, an increase in adrenergic activity by epinephrine had dose-dependent, opposite effects on ventricular electrical stability. Since beta-adrenergic blockade suppressed epinephrine-induced PVC and polymorphic VA, it might be considered for supplemental therapy to suppress VA in patients presenting with LQT3.

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  • Comparison of conduction delay in the right ventricular outflow tract between Brugada syndrome and right ventricular cardiomyopathy: investigation of signal average ECG in the precordial leads 査読

    Hiroshi Furushima, Masaomi Chinushi, Kazuki Okamura, Kenichi Iijima, Satoru Komura, Yasutaka Tanabe, Shinsuke Okada, Daisuke Izumi, Yoshifusa Aizawa

    EUROPACE   9 ( 10 )   951 - 956   2007年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Background In both Brugada syndrome (BS) and arrhythmogenic right ventricular cardiomyopathy (ARVC), electrical abnormalities in the right ventricular outflow tract (RVOT) are important for arrhythmogenesis.
    Objectives The aim of this study was to compare conduction delay in the right ventricular in BS with that in ARVC using the signal-averaged electrocardiogram.
    Methods Twenty patients with BS (18 men and 2 women; 55 +/- 12 years old; 9 symptomatic and 11 asymptomatic) and eight patients with ARVC (six men and two women; 53 +/- 16 years old) were included. We assessed the presence of late potentials (LPs) and the filtered QRS duration (fQRSd) in V-2 and V-5 using a high-pass filter of 40 Hz (fQRSd:40) and 100 Hz (fQRSd:100).
    Results In ARVC, there was no significant difference in fQRSd:40 between V2 and V5 (158 +/- 19 vs. 145 +/- 17 ms, respectively): however, in BS, fQRSd:40 in V2 was significantly longer than fQRSd:40 in V5 (147 +/- 15 vs. 125 +/- 10 ms, P < 0.001). In ARVC, there was no significant difference between fQRSdA0 and fQRSd:100 in V-2 and V-5 (158 +/- 19 vs. 142 +/- 23 ms and 145 +/- 17 vs. 132 +/- 9 ms, respectively). In contrast, in BS, fQRSd:100 was significantly shorter than fQRSd:40 in V2 (110 +/- 8 ms vs. 147 +/- 15, P < 0.001). The relative decrease in fQRSd: 100 compared with fQRSd:40 in V2 was significantly greater in BS than in ARVC.
    Conclusion The dominant prolongation of the fQRSd in the right precordial. lead in BS was different from the characteristics of ARVC, which may be caused by the conduction delay due to fibro-fatty replacement in RV.

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  • Effect of dl-sotalol on mortality and recurrence of ventricular Tachyarrhythmias: Ischemic compared to nonischemic cardiomyopathy 査読

    Hiroshi Furushima, Masaomi Chinushi, Kazuki Okamura, Satoru Komura, Yasutaka Tanabe, Akinori Sato, Daisuke Izumi, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   30 ( 9 )   1136 - 1141   2007年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    Objective: We compared the effectiveness of sotalol on mortality and the recurrence of ventricular tachyarrhythmia (VTA) between idiopathic dilated cardiomyopathy (IDCM) and coronary artery disease (CAD).
    Patients: Forty patients with spontaneous VTA and induced VTA associated with CAD (n = 23) and IDCM (n = 17) were studied. In all patients, sotalol was prescribed and an electrophysiologic study (EPS) was performed to evaluate its effect on the induction of VTA. There were no significant differences in left ventricular ejection fraction (LVEF) between CAD and IDCM (35% +/- 10% vs. 35% +/- 12%).
    Results: After sotalol, there were no significant differences in the QTc interval on electrocardiogram (ECG) or in the effective refractory period in the apex of the right ventricle between the two groups, but sotalol was more effective in preventing the induction of VTA in CAD than in IDCM (65% vs. 29%; P < 0.05). During a mean follow-up period of 47 +/- 27 months, the overall VTA recurrence rate was significantly lower in CAD than in IDCM (P < 0.01). The all-cause mortality rate tended to be lower in CAD than in IDCM, but the difference was not significant (P = 0.07). Electrical storm (ES) occurred more frequently in IDCM than in CAD, (41% vs. 13%; P < 0.05), and all patients with ES (n = 10) failed to respond to sotalol as assessed by EPS.
    Conclusion: Sotalol reduced the overall VTA recurrence rate and all-cause mortality more in CAD than in IDCM.

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  • Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome 査読

    Masaomi Chinushi, Satoru Komura, Daisuke Izumi, Hiroshi Furushima, Yasutaka Tanabe, Takashi Washizuka, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   30 ( 5 )   662 - 671   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    Background: In patients with Brugada syndrome, class I antiarrhythmic drugs can trigger ventricular arrhythmias (VA). The incidence and initial characteristics of VA that developed after pilsicainide was examined in 28 patients with Brugada-type electrocardiographic (ECG) abnormalities and with a positive response in the pilsicainide test. The clinical outcome was also compared between patients with and without pilsicainide-induced VA.
    Methods and Results: In all patients, pilsicainide increased ST segment elevation and accentuated type 1 ECG changes. Ventricular tachycardia (VT) developed in 3 patients and premature ventricular complexes (PVC) in 2 other patients. These 5 patients (group I) had higher ST segment elevation in lead V2 on the ECG at baseline and after pilsicainide and showed a longer QTc interval after pilsicainide than the other 23 patients (group II). However, there was no difference between the 2 groups regarding incidence of prior cardiac events, results of signal-averaged ECG, HV interval, inducibility of ventricular fibrillation by programmed electrical stimulation, or QRS duration. In 1 patient, PVC originated from 3 sites, 2 of which triggered polymorphic VT. The right ventricular (RV) outflow tract was the origin of 2 types of PVC, and other RV sites of 5 other types. During a 45 +/- 37 months follow-up, polymorphic VT recurred in 2 patients in group II.
    Conclusions: Pilsicainide induced VA in some patients with Brugada syndrome, but this result may not be used as a parameter of the risk stratification of Brugada syndrome. Multiple PVC induced by pilsicainide and triggering polymorphic VT originated from several RV sites is an important factor when considering patients for treatment with catheter ablation.

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  • Leiomyosarcoma of the abdominal aorta: A rare cause of renovascular hypertension 査読

    Seitaro Iguchi, Bassam Alchi, Katsuaki Asakawa, Daisuke Izumi, Takeshi Kashimura, Mitsuhiro Ueno, Farah Safar, Shinichi Nishi, Ichiei Narita, Fumitake Gejyo

    HYPERTENSION RESEARCH   30 ( 3 )   279 - 283   2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE  

    We describe the case of a 44-year-old woman who presented with renovascular hypertension caused by primary leiomyosarcoma of the abdominal aorta that had metastasized into the renal arteries. Despite an extensive radiological evaluation, the diagnosis was mistaken first for Takayasu's arteritis and then for retroperitoneal hematoma or neoplasm. The patient developed renal failure due to bilateral renal infarction, and died 3 months after her initial presentation with ischemic colitis. Postmortem examination confirmed the diagnosis.

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  • Bepridil for drug-refractory ventricular tachyarrhythmias 査読

    Daisuke Izumi, Masaomi Chinushi, Hiroshi Watanabe, Takashi Washizuka, Kazuki Okamura, Satoru Komura, Yasutaka Tanabe, Hiroshi Furushima, Yoshifusa Aizawa

    INTERNAL MEDICINE   46 ( 3 )   119 - 124   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Aims To avoid frequent discharges of implantable cardioverter defibrillators, antiarrhythmic drugs may be needed in some patients with ventricular tachyarrhythmias. For ventricular tachyarrhythmias refractory to conventional antiarrhythmic drugs, we evaluated the efficacy of bepridil, a multiple ion-channel blocker.
    Methods and results Sixteen patients with structural heart disease and ventricular tachyarrhythmias refractory to multiple antiarrhythmic drugs (4.1 +/- 1.6 drugs including class III drugs) were enrolled. Bepridil was prescribed at a mean dose of 156 +/- 40 mg/day. Bepridil prolonged the QT/QTc interval without affecting heart rate or the QRS duration. During a mean follow-up of 52 +/- 44 months, bepridil completely suppressed ventricular tachyarrhythmias in 6 of the 16 patients (38%) and the drug decreased the frequency of ventricular tachyarrhythmia recurrences by> 75% in 3 of the other 10 patients. The markers of complete suppression of ventricular tachyarrhythmias during bepridil treatment included a smaller number of VT morphologies, a better NYHA functional class, and a greater drug-induced prolongation of the QT/QTc interval. The result of electrophysiologic study-guided evaluation of bepridil was closely associated with the clinical efficacy of bepridil in 7 of 8 patients.
    Conclusion Bepridil appears to be useful to suppress drug-refractory ventricular tachyarrhythmia recurrence.

    DOI: 10.2169/internalmedicine.46.6024

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  • Multiple premature beats triggered ventricular arrhythmias during pilsicainide infusion in a patient with inferior ST-segment elevation 査読

    Masaomi Chinushi, Daisuke Izumi, Hiroshi Furushima, Hiroshi Watanabe, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   29 ( 12 )   1445 - 1448   2006年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    A 17-year-old man was referred to our hospital for treatment of common paroxysmal atrial flutter. His electrocardiogram at rest showed subtle ST-segment elevation in leads II, III, and aV(F). Intravenous pilsicainide caused further ST-segment elevation in the inferior leads, new ST-segment depression in leads V2-V6, two distinct forms of premature ventricular complexes (PVCs) triggering short runs of polymorphic ventricular tachycardia (VT). An infusion of isoproterenol suppressed these arrhythmias and normalized the ST-segment. Pilsicainide may induce PVCs and polymorphic VT in atypical Brugada syndrome.

    DOI: 10.1111/j.1540-8159.2006.00562.x

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  • Role of autonomic nervous activity in the antiarrhythmic effects of magnesium sulfate in a canine model of polymorphic ventricular Tachyarrhythmia associated with prolonged QT interval 査読

    Masaomi Chinushi, Daisuke Izumi, Satoru Komura, Shizue Ahara, Akinori Satoh, Hiroshi Furushima, Takashi Washizuka, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   48 ( 3 )   121 - 127   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    This study was performed to examine the role played by the autonomic nervous system in the antiarrhythmic effects of magnesium sulfate (Mg++) in a canine model of polymorphic ventricular tachyarrhythmia facilitated by anthopleurin-A and a slower heart rate induced QT interval prolongation. In 6 experiments, complete atrioventricular block was created to control the heart rate and bradycardia at 800- to 1500-ms cycle lengths was applied for 60 see before and after drug-induced autonomic block. Transmural unipolar electrograms were recorded from multipolar needle electrodes, and activation-recovery intervals (ARI) were measured. Before drug-induced autonomic block, polymorphic ventricular tachyarrhythmia developed in all 6 experiments during bradycardia before but not after the administration of Mg++ (0.2 ml/kg intravenous bolus). During drug-induced autonomic block, triggered premature activity decreased without significant changes in underlying dispersion of repolarization and polymorphic ventricular tachyarrhythmia developed during bradycardia in I experiment. Administration of Mg++ during drug-induced autonomic block eliminated premature activity and polymorphic ventricular tachyarrhythmia during bradycardia. The distribution of left ventricular (IV) and right ventricular repolarization and dispersion of transmural repolarization were analyzed before and 60 see after Mg+ administration during ventricular pacing at 80 bpm. Mg++ caused a modest shortening of ARI at all sites before and after drug-induced autonomic block. Since ARI shortening was greater at the mid-myocardial sites than at other IV sites, Mg++ decreased transmural ARI dispersion from 77 +/- 16 to 46 +/- 21 ms before drug-induced autonomic block and from 79 +/- 7 to 51 +/- 16 ms after drug-induced autonomic block. The antiarrhythmic effects of Mg++ in this model of long QT syndrome were attributable to its direct pharmacological properties and not to changes in ambient autonomic nervous activity. The blockade of sympathetic activity decreased the incidence of premature events and partially suppressed polymorphic ventricular tachyarrhythmia in this model.

    DOI: 10.1097/01.fjc.0000246262.29397.7a

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  • Decrease in amplitude of intracardiac ventricular electrogram and inappropriate therapy in patients with an implantable cardioverter defibrillator 査読

    Hiroshi Watanabe, Masaomi Chinushi, Daisuke Izumi, Akinori Sato, Shinsuke Okada, Kazuki Okamura, Satoru Komura, Yukio Hosaka, Hiroshi Furushima, Takashi Washizuka, Yoshifusa Aizawa

    INTERNATIONAL HEART JOURNAL   47 ( 3 )   363 - 370   2006年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INTERNATIONAL HEART JOURNAL ASSOCIATION  

    Intracardiac electrograms are important for discrimination of tachyarrhythmia by implantable cardioverter defibrillators (ICD). A low R-wave can cause not only undersensing of ventricular tachyarrhythmia but also inappropriate discharges due to oversensing of unexpected signals because of its characteristic sensing algorithm. Therefore, this study aimed to investigate adverse events associated with R-wave amplitude. We included 115 consecutive patients followed-up over one year after implantation of a transvenous ICD system. The status of the ICD was checked every 3 months and intracardiac ventricular electrograms were analyzed. The decrease in R-wave amplitude was high in arrhythmogenic hypertrophy cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy (ARVC), and sarcoidosis. Low R-waves (< 5.0 mV) were observed in 13 patients at a follow-up of 15 +/- 16 months after implantation, and the mean R-wave was 3.0 +/- 0.8 mV. The frequency of low R-waves was high in ARVC (38%), sarcoidosis (33%), and dilated cardiomyopathy (17%). All of the dilated cardiomyopathy patients with low R-waves had severe left ventricular dysfunction. Inappropriate ICD therapy resulting from T-wave oversensing occurred in 7 patients and the R-wave was < 5.0 mV in 6 of the patients. The frequency of inappropriate therapy was high in patients with sarcoidosis. In 3 patients, inappropriate therapy caused ventricular tachyarrhythmia. In conclusion, decreases in R-wave amplitude occurred in some progressive cardiac disorders and caused inappropriate ICD discharges having arrhythmogenicity. Physicians should attempt to obtain a high R-wave amplitude during ICD implantation and careful follow-up is required, especially in patients with ARVC or sarcoidosis.

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  • Elimination of late potentials by quinidine in a patient with Brugada syndrome 査読

    H Watanabe, M Chinushi, A Osaki, K Okamura, D Izumi, S Komura, Y Hosaka, Y Tanabe, H Furushima, T Washizuka, Y Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   39 ( 1 )   63 - 66   2006年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    The beneficial effects of quinidine on ST-segment elevation, inducible ventricular tachyarrhythmias, and episodes of ventricular tachyarrhythmia have been reported in Brugada syndrome. This is the first report describing quinidine-induced elimination of the late potential, which is considered one of the parameters for an arrhythmic event, in a patient with Brugada syndrome. (c) 2006 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.jelectrocard.2005.07.009

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  • Effects of intravenous magnesium in a prolonged QT interval model of polymorphic ventricular tachycardia focus on transmural ventricular repolarization 査読

    M Chinushi, H Sugiura, S Komura, T Hirono, D Izumi, M Tagawa, H Furushima, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   28 ( 8 )   844 - 850   2005年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    Background: This study was performed to clarify the antiarrhythmic effects of magnesium sulfate (Mg++) in a prolonged QT interval canine model of polymorphic ventricular tachyarrhythmia (VTA).
    Methods: In six experiments in a canine model of prolonged QT by anthopleurin-A, Mg++ was administered in boluses of 0.2 mL/kg during repetitive episodes of self-terminating polymorphic VTA or frequent premature ventricular complexes (PVCs). The distribution of ventricular repolarization across the left ventricular(LV) wall and dispersion of transmural repolarization were analyzed before, and 30 and 120 seconds after Mg++ administration, during ventricular pacing at 100 bpm. Transmural unipolar electrograms were recorded from multipolar needle electrodes, and local activation-recovery intervals (ARI) were measured.
    Results: Mg++ rapidly eliminated self-terminating polymorphic VTA and all isolated PVCs. During ventricular pacing at 100 bpm, Mg++ caused modest shortening of ARI at all recording sites. Since the magnitude of ARI shortening was greater at mid-myocardial sites than at other ventricular sites, mean transmural ARI dispersion decreased from 80 +/- 22 to 45 +/- 18 ms within 30 seconds after Mg++ injection. However, this effect was transient, and, at 120 seconds after Mg++ administration, ARI had increased all sites and transmural ARI dispersion lengthened to 65 18 ms. Besides suppression of triggered premature activity, homogenization of transmural ventricular repolarization was associated with the antiarrhythmic effects of intravenous Mg++ in this model.
    Conclusion: Since these effects were transient, a continuous intravenous infusion of Mg++ is preferred to prevent recurrences of VTA.

    DOI: 10.1111/j.1540-8159.2005.00178.x

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MISC

  • 心室細動を生じ、冠攣縮および器質的冠動脈狭窄を合併した右冠動脈左冠尖起始の一例

    布施 拓也, 松尾 聖, 高野 俊樹, 大久保 健志, 萱森 裕美, 八木原 伸江, 飯嶋 賢一, 保屋野 真, 柳川 貴央, 和泉 大輔, 小澤 拓也, 柏村 健, 尾崎 和幸, 南野 徹

    日本心臓病学会学術集会抄録   66回   EP - 060   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本心臓病学会  

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  • 高位肋間におけるJ点上昇と致死性不整脈リスクに関する検討

    長谷川 祐紀, 渡部 裕, 大槻 総, 飯嶋 賢一, 八木原 伸江, 佐藤 光希, 和泉 大輔, 南野 徹

    日本心臓病学会学術集会抄録   66回   O - 078   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本心臓病学会  

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  • 下壁由来の心室期外収縮が心室細動のトリガーと考えられたBrugada症候群の1例

    久保田 直樹, 長谷川 祐紀, 佐藤 光希, 松尾 聖, 八木原 伸江, 飯嶋 賢一, 和泉 大輔, 南野 徹

    心臓   50 ( Suppl.1 )   75 - 82   2018年8月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    52歳男性。早朝に胸部不快のため受診し心房細動を指摘された。観察中に下方軸の心室期外収縮(PVC)から心室細動(VF)をきたし心肺蘇生を受けた。心電図では下壁誘導と左胸部誘導に広くJ波を認めた。器質的心疾患はなく、冠動脈造影では有意狭窄や冠攣縮誘発性は認めなかった。Pilsicainide負荷で右胸部誘導のCoved型ST上昇を認め、Brugada症候群と診断した。皮下植込み型除細動器の植込み術直後とその3週間後に、今度は上方軸のPVCからVFをきたした。Isoproterenol負荷、Propofol鎮静刺激、Pilsicainide負荷ではPVCは誘発されなかった。心臓電気生理検査では右室からの単発期外刺激にて容易にVFが誘発され3度の体外直流通電でようやく停止した。VF再発予防としてBepridilを開始し、その後VFの再発を認めていない。Brugada症候群では右室流出路における不整脈基質の存在が想定され、VFに先行するPVCは左脚ブロック・下方軸型が多い。本例のようなJ波を合併したBrugada症候群では、広範な不整脈基質の存在が下壁由来のPVCの発生やVFの易誘発性に寄与していた可能性があった。J波を合併したBrugada症候群においてVFに先行するPVCを評価した報告は乏しく、貴重な症例と考えられ報告する。(著者抄録)

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  • 早期再分極における心房細動発症リスクの検討

    長谷川 祐紀, 渡部 裕, 大槻 総, 飯嶋 賢一, 八木原 伸江, 佐藤 光希, 和泉 大輔, 南野 徹

    日本内科学会雑誌   107 ( Suppl. )   203 - 203   2018年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • 各種抗凝固療法における血管損傷時の凝固系の反応の検討

    大槻 総, 和泉 大輔, 須田 将吉, 佐藤 光希, 長谷川 祐紀, 八木原 伸江, 飯嶋 賢一, 池主 雅臣, 南野 徹

    日本内科学会雑誌   107 ( Suppl. )   163 - 163   2018年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • テストステロン減少が病態の顕性化に寄与したと考えられた高齢発症のQT延長症候群の1例

    長谷川 祐紀, 坂口 裕太, 大槻 総, 飯嶋 賢一, 八木原 伸江, 佐藤 光希, 和泉 大輔, 池主 雅臣, 南野 徹

    心臓   49 ( Suppl.1 )   43 - 49   2017年8月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    27歳時に片側睾丸摘出の既往がある61歳男性。母親とその姉妹2人が20歳頃に突然死している。失神や多形性心室頻拍(TdP)の既往はなかったが、50歳頃より検診でQT延長を指摘されていた。今回、運転中に初めて失神し搬送された。この際、著明なQT延長(QTc=666ms)とTdP頻発を認めた。器質的心疾患は認めず、家族歴から先天性QT延長症候群と考えられたが、本例では60歳代での心原性失神の初発であった。検診心電図では、QT延長は段階的に顕性化していた。本例では数日前からエフェドリン含む感冒薬の内服歴がありTdP発症の要因となったと考えられた。さらに本例では明らかなテストステロン低値を認めており、QT延長症候群の高齢での顕性化に寄与したと考えられた。QT延長例や潜在的素因を持つ例に内分泌的異常や薬剤など幅広い修飾因子が加わることで、高齢で初回発作をきたす例があり注意を要する。(著者抄録)

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  • Emery-Dreifuss型筋ジストロフィに合併し、急激な心機能低下を認めたラミン関連心筋症の1例

    南場 一美, 柏村 健, 大野 由香子, 藤木 伸也, 渡邊 達, 林 由香, 田中 孔明, 小幡 裕明, 佐藤 光希, 和泉 大輔, 塙 晴雄, 南野 徹

    心臓   49 ( 4 )   405 - 410   2017年4月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    症例は26歳女性。7歳時に先天性ミオパチーと診断された。5年前より心拍数40/分台の洞徐脈を指摘されていた。入院5ヵ月前より心不全症状、前失神症状が出現し、ペースメーカ植込みが施行された。その際LVDd/Ds=5.4/3.7cm、EF=58%と心機能は保たれていたが、3ヵ月後にはLVDd/Ds=5.3/4.1cm、EF=36%と急激に心機能は悪化し、心不全も徐々に増悪した。遺伝子検査にてLMNA遺伝子変異を認め、ラミン関連心筋症と診断した。また、幼児期より緩徐進行性の筋力低下や関節拘縮を呈し、心伝導障害・心筋症の出現とLMNA遺伝子異常を認め、既存のミオパチーをEmery-Dreifuss型筋ジストロフィと診断した。2ヵ月後には安静時呼吸苦が出現し、救急搬送された。LVDd/Ds=4.9/4.2cm、EF=28%と心機能はさらに悪化を認めた。ドブタミン併用下に、静注利尿薬、トルバプタン、ミルリノンを使用し、CRT-Dへのupgradeを施行し、徐々に心不全症状は改善した。カルベジロールを10mgまで漸増したが、低心拍出による全身倦怠感、腎機能増悪が出現し、静注強心薬からの離脱に難渋した。経口強心薬を併用しつつ、静注強心薬から離脱し、入院6ヵ月後に退院した。Emery-Dreifuss型筋ジストロフィに合併し、急激な心機能低下を認めたラミン関連心筋症の1例を経験したので報告する。(著者抄録)

    DOI: 10.11281/shinzo.49.405

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  • 植込み型除細動器を装着する虚血性心疾患患者において血管造影上の不完全な血行再建が与える植込み型除細動器療法への影響(Impact of Angiographic Incomplete Revascularization on Implantable Cardioverter-Defibrillator Therapy in Ischemic Heart Disease Patients with Implantable Cardioverter-Defibrillator)

    高野 俊樹, 田中 孔明, 柳川 貴央, 佐藤 光希, 和泉 大輔, 小澤 拓也, 尾崎 和幸, 佐藤 政仁, 南野 徹

    日本循環器学会学術集会抄録集   81回   PJ - 153   2017年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 断線によるCRT左室リード留置部位の変更で異なる臨床経過を呈した3例

    長谷川 祐紀, 和泉 大輔, 大槻 総, 飯嶋 賢一, 八木原 伸江, 佐藤 光希, 池主 雅臣, 南野 徹

    心臓   48 ( Suppl.2 )   179 - 186   2016年12月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    CRT-D植込み後、左室リード断線による心不全悪化をきたし、冠静脈狭窄のため異なる部位への再留置を余儀なくされた3症例を経験した。3例とも左室リードは単純牽引で用手的抜去可能であった。症例1:68歳女性。拡張型心筋症(DCM、EF=37%、QRS=132ms、NYHAIII)、徐脈性心房細動、心室頻拍のためCRT-Dを植込み、NYHAIIに改善した。植込み8年2月後に左室リード断線をきたした。後側壁側から側壁側への再留置となり、その後初回留置後より利尿剤の減量が可能となった。症例2:71歳男性。DCM(EF=32%、QRS=180ms、NYHAIII)のためCRT-Dを植込み、NYHAIIに改善した。2年3ヵ月後に左室リード断線をきたした。心室刺激閾値高値や横隔神経捕捉のため目標領域への留置が困難であり、中心静脈経由で後側壁側に再留置したが、心不全は改善せず術後54日目に死亡した。症例3:57歳女性。DCM(EF=17%、QRS=190ms、NYHAIII)のためCRT-Dを植込みNYHAIIに改善した。4年7ヵ月後に左室リード断線をきたした。前側壁側から前壁側への再留置となり、その後心不全が悪化した(NYHAIII)。結語:左室リードの再留置時には、同部位への留置が困難となる可能性、他部位への留置によりCRTの効果が異なる可能性を考慮する必要がある。(著者抄録)

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  • 機能性僧帽弁閉鎖不全症を伴うEF10%台の低心機能拡張型心筋症に対して、弁下組織温存僧帽弁置換術が有効であった2例

    南場 一美, 柏村 健, 長谷川 祐紀, 藤木 伸也, 渡邊 達, 林 由香, 田中 孔明, 小幡 裕明, 佐藤 光希, 和泉 大輔, 南野 徹, 長澤 綾子, 佐藤 裕喜, 岡本 竹司, 青木 賢治, 名村 理

    日本心臓病学会学術集会抄録   64回   P - 302   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本心臓病学会  

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  • クラリスロマイシン内服中に徐脈を契機に多形性心室頻拍をきたした高齢者QT延長症候群の1例

    長谷川 祐紀, 和泉 大輔, 大槻 総, 八木原 伸江, 飯嶋 賢一, 佐藤 光希, 池主 雅臣, 南野 徹

    心臓   48 ( Suppl.1 )   155 - 155   2016年8月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

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  • 虚血性心疾患患者における植込み型除細動器遠隔期作動率とその臨床的予測因子

    高野 俊樹, 田中 孔明, 柳川 貴央, 佐藤 光希, 和泉 大輔, 小澤 拓也, 尾崎 和幸, 南野 徹

    日本心血管インターベンション治療学会抄録集   25回   MP280 - MP280   2016年7月

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    記述言語:英語   出版者・発行元:(一社)日本心血管インターベンション治療学会  

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  • 高血圧性心肥大で経過観察中に持続性心室頻拍を発症し蘇生された1例

    長谷川 祐紀, 和泉 大輔, 大槻 総, 八木原 伸江, 佐藤 光希, 小澤 拓也, 渡部 裕, 池主 雅臣, 南野 徹

    心臓   47 ( Suppl.1 )   38 - 43   2015年8月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    症例は49歳男性。高血圧、糖尿病のためカルシウム拮抗薬、インスリン治療を受けていた。心電図では肥大性ST変化を認め、心エコーでは壁厚15mmの対称性左室肥大を認められていたが、左室収縮能は保持されていた。トラック運転中に意識消失し追突事故を起こした。救急隊が250bpmの脈をふれない単形性心室頻拍(VT)を確認し、心肺蘇生中にVTは停止し回復した。緊急搬送後の心臓精査にて冠動脈病変はなく、心臓MRIで心室中隔中層の遅延造影所見を認めた。電気生理学的検査では血行動態が破綻するRBBB型とLBBB型の複数波形の単形性VTが誘発された。一部のVTでは、エントレインメント所見を認めリエントリー機序が想定され、心室中隔に拡張期電位を認めたことから同領域が不整脈基盤となっている可能性が示唆された。左室肥大例において心臓MRIで遅延造影所見を認める場合、不整脈リスクを考慮すべきと考えられ、文献的考察を交えて報告する。(著者抄録)

    DOI: 10.11281/shinzo.47.S1_38

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  • 虚血と不整脈 J波と虚血性心室細動の関係 冠攣縮狭心症における検討

    佐藤 光希, 渡部 裕, 池主 雅臣, 和泉 大輔, 小澤 拓也, 伊藤 英一, 田辺 恭彦, 相澤 義房, 南野 徹

    心電図   34 ( 2 )   118 - 126   2014年10月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

    近年、心室細動(VF)に関連する疾患として、J波症候群という新しい疾患群が提唱された。虚血性心疾患においてもJ波の存在やその変化は、心筋虚血とVF発生との関係を解析するうえで非常に重要である。われわれは、心筋虚血による超急性期のJ波の変化とVF発生の関係を明らかにするため、冠攣縮誘発試験施行例のうち虚血が誘発された67例において、J波とVF発生の関係を検討した。その結果、67例中14例において安静時心電図にJ波が存在していた。冠攣縮誘発による虚血に伴って、安静時心電図のJ波は14例中7例で増悪を示し、そのうち4例でVFに至った。一方で、安静時心電図でJ波が見られなかった53例のうち、4例で虚血に伴って新たなJ波が出現したが、VFは生じなかった。J波に変化がみられなかった49例のうち1例でのみ、VFを生じた。冠攣縮誘発試験前のJ波の存在は、冠攣縮誘発時のVF発生に関係した(OR 20.8、p=0.006)。また、冠攣縮誘発時のJ波の増悪・出現もVF発生に関与した(OR 31.4、p=0.002)。このことから、J波は冠攣縮誘発時の心筋虚血の超急性期において、VFに関係していることが示された。心筋虚血の超急性期におけるJ波を含めた特異な心電図変化を解析することは、虚血性VFや虚血性心疾患の突然死のリスク階層化にも有用と考えられる。さらに研究を進めていくことで、虚血性VFの機序や病態が解明し、治療に貢献していくことが期待される。(著者抄録)

    DOI: 10.5105/jse.34.118

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  • 左室基部後壁起源の心室性期外収縮により心室細動を繰り返した特発性心室細動の1例

    勝海 悟郎, 古嶋 博司, 和泉 大輔, 大槻 総, 長尾 智美, 飯嶋 賢一, 佐藤 光希, 小田 雅人, 渡部 裕, 池主 雅臣, 南野 徹

    心臓   46 ( Suppl.2 )   56 - 61   2014年8月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    生来健康の27歳男性。父親が57歳時に突然死している。深夜飲酒中に心室細動をきたし当院に搬送された。心肺蘇生、低体温療法を施行し、後遺症なく回復した。心エコー、心臓MRI、冠動脈CTで器質的心疾患は認めなかった。Type 3 Brugada型心電図を認めたが、ICD植え込み後に施行したピルシカイニド負荷試験ではtype 1様波形変化が1誘導のみであり、特発性心室細動と診断した。また、同検査中に右脚ブロック、左軸偏位型の心室性期外収縮を認めた。運動負荷試験後の夜間から早朝にこの心室性期外収縮より心室細動が惹起され、ショック作動を繰り返した。心臓電気生理検査では左室基部後壁心外膜側に心室性期外収縮の起源を認め、心内膜側から焼灼を試みたが、完全には抑制されなかった。その後、ベプリジル内服により心室性期外収縮、心室細動は抑制され、以後9ヵ月間再発なく経過している。心室細動を惹起する心室性期外収縮の起源が同定され、bepridilが奏功した特発性心室細動症例を経験したので文献的考察を加えて報告する。(著者抄録)

    DOI: 10.11281/shinzo.46.S2_56

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  • 非根治成人ファロー四徴症に脳梗塞を発症した66歳女性例

    三ツ間 友里恵, 赤岩 靖久, 二宮 格, 上村 昌寛, 高橋 哲哉, 下畑 享良, 西澤 正豊, 和泉 大輔, 南野 徹, 白石 修一, 高橋 昌, 土田 正則

    新潟医学会雑誌   128 ( 6 )   279 - 279   2014年6月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 右室流出路起源の期外収縮をトリガーとする多形性心室頻拍が見られた潜在性type2-QT延長症候群の1例

    佐藤 光希, 園田 桂子, 飯嶋 賢一, 八木原 伸江, 和泉 大輔, 渡部 裕, 古嶋 博司, 南野 徹, 阿部 晃, 池主 雅臣

    心臓   45 ( Suppl.3 )   135 - 135   2013年12月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    DOI: 10.11281/shinzo.45.S3_135

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  • 虚血と不整脈 J波と虚血性心室細動の関係 冠攣性狭心症における検討

    佐藤 光希, 渡部 裕, 池主 雅臣, 和泉 大輔, 小澤 拓也, 伊藤 英一, 田辺 恭彦, 相澤 義房, 南野 徹

    心電図   33 ( Suppl.4 )   S - 4   2013年9月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • 神経電気刺激と高周波通電による腎動脈自律神経興奮への介入

    池主 雅臣, 鈴木 克弥, 斉藤 修, 飯嶋 賢一, 和泉 大輔, 佐藤 光希, 古嶋 博司, 南野 徹, 岩渕 三哉

    心電図   33 ( Suppl.4 )   S - 4   2013年9月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • 多形性心室頻拍の契機となるLV summit領域の心室性期外収縮にカテーテルアブレーションが奏功した1例

    勝海 悟郎, 池主 雅臣, 飯嶋 賢一, 佐藤 光希, 和泉 大輔, 渡部 裕, 古嶋 博司, 南野 徹

    心臓   45 ( Suppl.2 )   19 - 19   2013年8月

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    記述言語:日本語   出版者・発行元:(公財)日本心臓財団  

    DOI: 10.11281/shinzo.45.S2_19

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  • ブルガダ症候群と診断された下顎骨骨折の1例

    大貫 尚志, 児玉 泰光, 黒川 亮, 嵐山 貴徳, 永井 孝宏, 和泉 大輔, 高木 律男

    口腔顎顔面外傷   12 ( 1 )   65 - 66   2013年6月

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    記述言語:日本語   出版者・発行元:日本口腔顎顔面外傷学会  

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  • 救命できたaborted sudden deathの集計

    林 由香, 藤木 伸也, 萱森 裕美, 渡辺 達, 園田 桂子, 飯嶋 賢一, 小田 雅人, 佐藤 光希, 小幡 裕明, 和泉 大輔, 小澤 拓也, 渡部 裕, 柏村 健, 伊藤 正洋, 古嶋 博司, 廣野 暁, 池主 雅臣, 塙 晴雄, 小玉 誠, 柳川 貴央, 本多 忠幸, 遠藤 裕

    新潟医学会雑誌   126 ( 5 )   269 - 269   2012年5月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 心電図同期下CTによる疣贅描出が診断に有用であったリード感染症の1例

    園田 桂子, 伊藤 正洋, 小幡 裕明, 和泉 大輔, 池主 雅臣, 池田 洋平, 堀 祐郎, 吉村 宣彦

    Journal of Arrhythmia   28 ( Suppl. )   391 - 391   2012年5月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • Ventricular Tachyarrhythmias Associated with Congestive Heart Failure (Therapeutic Roles of Antiarrhythmic Drugs and Catheter Ablation)

    Masaomi Chinush, Hiroshi Furushima, Daisuke Izumi, Kenichi Iijima, Yoshifusa Aizawa

    JOURNAL OF CARDIAC FAILURE   17 ( 9 )   S126 - S126   2011年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    Web of Science

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  • 当院における冠動脈バイパス術後心房細動の発症危険因子/予防因子についての検討

    八木原 伸江, 池主 雅臣, 古嶋 博司, 長谷川 奏恵, 真田 明子, 飯嶋 賢一, 和泉 大輔, 保坂 幸男, 渡部 裕, 伊藤 正洋, 廣野 暁, 菊地 千鶴男, 竹久保 賢, 林 純一, 相澤 義房

    新潟医学会雑誌   125 ( 1 )   49 - 49   2011年1月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • PCPSによる長期(14日間)循環管理を必要とした劇症型心筋炎

    八木原 伸江, 和泉 大輔, 長尾 智美, 田中 孔明, 伊藤 正洋, 塙 晴雄, 小玉 誠, 相澤 義房, 浅見 冬樹, 北原 哲彦, 菊池 千鶴男, 高橋 昌, 三間 渉, 岡田 慎輔, 阿部 暁, 樋口 浩太郎, 大塚 英明

    新潟医学会雑誌   124 ( 10 )   581 - 581   2010年10月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 1 レジオネラによる重症敗血症に合併した一過性心筋障害の1例(II.テーマ演題,第257回新潟循環器談話会)

    鈴木 友康, 伊藤 正洋, 和泉 大輔, 小澤 拓也, 太刀川 仁, 廣野 暁, 塙 晴雄, 小玉 誠, 相澤 義房

    新潟医学会雑誌   123 ( 5 )   259 - 259   2009年5月

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    記述言語:日本語   出版者・発行元:新潟医学会  

    CiNii Article

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  • U波の交代現象と変動を認めた原発性不整脈疾患の3例

    保坂 幸男, 池主 雅臣, 古嶋 博司, 相澤 義泰, 和泉 大輔, 佐藤 光希, 飯嶋 賢一, 真田 明子, 相澤 義房

    心電図   28 ( 5 )   471 - 471   2008年10月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • リンパ腫の心筋内浸潤によりT波の陰性化を生じた2症例

    真田 明子, 池主 雅臣, 富田 任, 鈴木 友康, 飯嶋 賢一, 佐藤 光希, 和泉 大輔, 保坂 幸男, 伊藤 正洋, 古嶋 博司, 相澤 義房

    心電図   28 ( 5 )   471 - 471   2008年10月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • Bentall手術後の左冠動脈入口部狭窄に対して経皮的冠動脈形成術を施行した1例

    木村 新平, 布施 公一, 和泉 大輔, 柏村 健, 伊藤 正洋, 広野 暁, 小玉 誠, 相澤 義房, 曽川 正和, 名村 理, 竹久保 賢, 林 純一, 那須野 暁光

    Circulation Journal   71 ( Suppl.III )   948 - 948   2007年10月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

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  • 右室起源の心室頻拍で不整脈源性右室心筋症の診断を満たした例と満たさなかった例の比較

    岡村 和気, 池主 雅臣, 古嶋 博司, 岡田 慎輔, 佐藤 光希, 和泉 大輔, 相澤 義泰, 小村 悟, 渡部 裕, 保坂 幸男, 山下 文男, 田辺 靖貴, 鷲塚 隆, 相澤 義房

    心電図   25 ( 5 )   419 - 419   2005年9月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • 解剖学的峡部へのブロックライン作成での所見から心外膜側に伝導路の存在が示唆された通常型心房細動の1症例

    小村 悟, 池主 雅臣, 佐藤 光希, 岡田 慎輔, 岡村 和気, 和泉 大輔, 相澤 義泰, 渡部 裕, 山下 文男, 田辺 靖貴, 古嶋 博司, 鷲塚 隆, 相澤 義房

    心電図   25 ( 5 )   426 - 426   2005年9月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • 家族性房室ブロックに洞不全症候群を合併した進行性心臓伝導障害でSCN5A(D1275N)の遺伝子異常を認めた1症例

    小村 悟, 池主 雅臣, 佐藤 光希, 岡田 慎輔, 岡村 和気, 和泉 大輔, 相澤 義泰, 渡部 裕, 山下 文男, 田辺 靖貴, 古嶋 博司, 鷲塚 隆, 相澤 義房

    心電図   25 ( 5 )   435 - 435   2005年9月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • 先天性心疾患術後例に合併する単形性心室頻拍の治療

    古嶋 博司, 池主 雅臣, 岡村 和気, 和泉 大輔, 岡田 慎輔, 小村 悟, 渡部 裕, 山下 文男, 田辺 靖貴, 相澤 義泰, 鷲塚 隆, 相澤 義房

    心電図   25 ( 5 )   417 - 417   2005年9月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

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  • ステロイド療法が肺高血圧症に著効したCrow-Fukase病の1症例

    小村 悟, 倉崎 桃里, 和泉 大輔, 畑田 勝治, 古嶋 博司, 大倉 裕二, 八木沢 久美子, 塙 晴雄, 小玉 誠, 相澤 義房, 高木 正仁, 小澤 鉄太郎, 西澤 正豊

    新潟医学会雑誌   119 ( 6 )   366 - 366   2005年6月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 植込み型除細動器患者における心室電位低下の頻度と臨床的特徴

    渡部 裕, 岡田 真輔, 和泉 大輔, 岡村 和気, 相澤 義泰, 保坂 幸男, 田辺 靖貴, 古嶋 博司, 相澤 義房, 池主 雅臣, 田辺 直人, 鷲塚 隆

    不整脈   21 ( 2 )   220 - 220   2005年4月

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    記述言語:日本語   出版者・発行元:(NPO)日本不整脈学会  

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  • 植込み型除細動器不適切作動の検討

    和泉 大輔, 池主 雅臣, 渡部 裕, 鷲塚 隆, 岡村 和気, 相澤 義泰, 小村 悟, 山下 文男, 田辺 靖貴, 古嶋 博司, 相澤 義房

    不整脈   21 ( 2 )   221 - 221   2005年4月

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    記述言語:日本語   出版者・発行元:(NPO)日本不整脈学会  

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  • Tachycardia induced cardiomyopathyの臨床的特徴 治療ならび予後の検討

    岡村 和気, 池主 雅臣, 渡部 裕, 岡田 慎輔, 和泉 大輔, 相澤 義泰, 小村 悟, 保坂 幸男, 山下 文男, 田辺 靖貴, 古嶋 博司, 藤田 聡, 鷲塚 隆, 相澤 義房

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    記述言語:日本語   出版者・発行元:(NPO)日本不整脈学会  

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  • 特発性心室細動と器質的心疾患を有する心室性頻脈症例のICD治療

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受賞

  • 研究大賞

    2018年6月   臨床薬理研究振興財団  

    和泉 大輔

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