2022/12/10 更新

写真a

エノモト タカユキ
榎本 隆之
ENOMOTO Takayuki
所属
教育研究院 医歯学系 医学系列 特任教授
医歯学総合研究科 特任教授
職名
特任教授
外部リンク

学位

  • 博士(医学) ( 1994年3月   大阪大学 )

研究キーワード

  • 婦人科腫瘍

  • gynecologic pathology

  • gynecologic oncology

  • 婦人科病理

研究分野

  • ライフサイエンス / 産婦人科学

  • ライフサイエンス / 人体病理学

経歴(researchmap)

  • :新潟大学 医歯学系 教授

    2012年 - 現在

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  • :大阪大学医学部 病院教授

    2008年 - 2012年

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  • :大阪大学医学部 助教授

    2007年 - 2008年

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  • :大阪大学医学部 講師

    2002年 - 2007年

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  • :大阪労災病院産婦人科   副部長

    1999年 - 2001年

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  • : Osaka University Medical School, Assistant Professor

    1996年 - 1999年

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  • :大阪大学医学部 助手

    1996年 - 1998年

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  • : Osaka University Medical School, Research Fellow

    1994年 - 1995年

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  • :大阪大学医学部 研究生

    1994年 - 1995年

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  • :大阪大学医学部 医員

    1991年 - 1994年

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  • : Osaka University Medical School, Staff fellow

    1991年 - 1994年

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  • : National Cancer Institute(U. S. A) Guest Researcher

    1986年 - 1991年

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  • :米国国立癌研究所 客員研究員

    1986年 - 1991年

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経歴

  • 新潟大学   教育研究院 医歯学系   特任教授

    2022年4月 - 現在

  • 新潟大学   医歯学総合研究科   特任教授

    2022年4月 - 現在

  • 新潟大学   医学部 医学科   教授

    2012年9月 - 2022年3月

  • 新潟大学   医歯学総合研究科 分子細胞医学専攻 遺伝子制御   教授

    2012年9月 - 2022年3月

学歴

  • 大阪大学   医学部   医学科

    - 1983年

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    国名: 日本国

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  • 大阪大学   Faculty of Medicine

    - 1983年

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所属学協会

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委員歴

  • 婦人科悪性腫瘍研究機構   理事長  

    2019年1月 - 現在   

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    団体区分:学協会

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  • 厚生労働省   患者申出療養評価会議技術専門委員  

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    団体区分:政府

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  • 日本癌治療学会   代議員  

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  • 日本産科婦人科学会   婦人科腫瘍委員会委員長  

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    団体区分:学協会

    日本婦人科腫瘍学会

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  • 日本婦人科腫瘍学会   常務理事  

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    団体区分:学協会

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  • 日本癌治療学会   機関紙編集委員、がん保険診療対策委員  

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  • 日本産科婦人科学会   常務理事(広報担当)  

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    団体区分:学協会

    日本臨床細胞診学会

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  • 日本臨床細胞学会   理事  

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    団体区分:学協会

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  • 厚生労働省   先進医療会議技術専門委員  

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    団体区分:政府

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取得資格

  • 日本産科婦人科専門医

  • 日本臨床細胞学会細胞診専門医

  • 婦人科腫瘍専門医

 

論文

  • The efficacy of human papillomavirus vaccination in young Japanese girls: the interim results of the OCEAN study. 国際誌

    Kosuke Hiramatsu, Yutaka Ueda, Asami Yagi, Akiko Morimoto, Tomomi Egawa-Takata, Satoshi Nakagawa, Eiji Kobayashi, Toshihiro Kimura, Tadashi Kimura, Ryoko Minekawa, Yumiko Hori, Kazuaki Sato, Eiichi Morii, Tomio Nakayama, Yoshimichi Tanaka, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Noriomi Matsumura, Masaki Mandai, Jyunko Saito, Yorihiko Horikoshi, Tetsu Takagi, Takayuki Enomoto, Kentaro Shimura

    Human vaccines & immunotherapeutics   18 ( 1 )   1951098 - 1951098   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Human papillomavirus (HPV) vaccine has been used to prevent chronic HPV infection, which accounts for cervical cancer. Japanese Ministry of Health, Labor and Welfare (MHLW) conducted an HPV vaccination campaign in 2010 and the Obstetrical Gynecological Society of Osaka initiated a multicenter, prospective cohort study in Osaka, Japan - OCEAN (Osaka Clinical resEArch of HPV vacciNe) study - to investigate the oncogenic HPV prevalence and the long-term protection rate of HPV vaccine. A total of 2814 participants were enrolled on their visit for HPV vaccination between 12 and 18 years old. Among them, 102 participants received HPV/Pap co-test as primary cancer screening at the age of 20-21. We compared the prevalence in two groups (the vaccinated and the unvaccinated group). HPV infection ratio was significantly lower in the vaccinated group compared to the unvaccinated (12.9% vs. 19.7%; p = .04). In particular, HPV 16 and 18 were not detected in the vaccinated group, while 4.9% of participants in the unvaccinated group were infected (p = .001), suggesting that vaccination provided effective protection against high-risk types of HPV. The cross-protection effect of HPV vaccines was also observed against HPV 31, 45, and 52. Although HPV vaccines were not contributed to the reduction of cervical intraepithelial neoplasia 1 (CIN) (p = .28), CIN2 or worse was not observed in vaccinated group. Our research showed that at the age of 20-21, HPV vaccine inhibited the infection of high-risk HPV and had impacted on the development to CIN2 or worse in Japan.

    DOI: 10.1080/21645515.2021.1951098

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  • Problems with catch-up HPV vaccination after resumption of proactive recommendations

    Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J B Hanley, Yutaka Ueda, Megumi Kurosawa, Sosuke Adachi, Etsuko Miyagi, Megumi Hara, Takayuki Enomoto

    The Lancet Oncology   23 ( 8 )   972 - 973   2022年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s1470-2045(22)00259-5

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  • Change of HPV vaccination rates in Japan: the effect of individual notifications implemented by local governments.

    Asami Yagi, Yutaka Ueda, Satoshi Nakagawa, Sayaka Ikeda, Mamoru Kakuda, Kosuke Hiramatsu, Ai Miyoshi, Eiji Kobayashi, Toshihiro Kimura, Kei Hirai, Tomio Nakayama, Etsuko Miyagi, Masayuki Sekine, Takayuki Enomoto, Tadashi Kimura

    International journal of clinical oncology   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: In Japan, in June 2013, The Ministry of Health, Labor and Welfare (MHLW) decided to temporarily suspend its official recommendation for the participation of girls in the national immunization program. The HPV vaccination rate in Japan soon declined to below 1%. In October 2020, the MHLW notified that the municipalities could and should begin to individually notify girls and their parents targeted for routine vaccination. We have examined how that type of individual notification has affected the number of vaccinations. METHODS: From 12 municipalities (with a combined total population of approximately 4.06 million), we collected vaccination data for all girls who attended grades 6 through 10 from April 2019 to March 2021. We analyzed the number of initial-round vaccinations that occurred by month and the timing and the subjects of the individual notifications. RESULTS: The annual vaccination rate for tenth-grade students in 2020 in the six municipalities that had implemented individual notification was 9.46% (342/3618), which was significantly higher than the rate of 3.22% (54/1676) in the three municipalities that had not implemented individual notification (p < 0.001). On the other hand, the annual vaccination rate for the sixth to ninth-grade students in 2020 in the six municipalities that had implemented individual notification was not significantly (p = 0.56) higher than the rate in the three municipalities that did not: 1.43% (197/13,785) versus 1.33% (83/6260), respectively. CONCLUSION: This study clearly demonstrates the importance of providing information for routine vaccination directly to the targets and their parents.

    DOI: 10.1007/s10147-022-02213-w

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  • Spontaneous healing of uterine rupture causing postpartum hemorrhage. 国際誌

    Shunya Sugai, Kazufumi Haino, Kaoru Yamawaki, Koji Nishijima, Takayuki Enomoto

    European journal of obstetrics, gynecology, and reproductive biology   274   255 - 257   2022年7月

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  • Trends in Pregnancy-Associated Cervical Cancer in Japan between 2012 and 2017: A Multicenter Survey. 国際誌

    Sayako Enomoto, Kosuke Yoshihara, Eiji Kondo, Akiko Iwata, Mamoru Tanaka, Tsutomu Tabata, Yoshiki Kudo, Eiji Kondoh, Masaki Mandai, Takashi Sugiyama, Aikou Okamoto, Tsuyoshi Saito, Takayuki Enomoto, Tomoaki Ikeda

    Cancers   14 ( 13 )   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Large-scale data on maternal and neonatal outcomes of pregnancy-associated cervical cancer in Japan are scarce, and treatment strategies have not been established. This multicenter retrospective observational study investigated clinical features and trends in pregnancy-associated cervical cancer treatments at 523 hospitals in Japan. We included cervical cancer cases that were histologically diagnosed (between 1 January 2012, and 31 December 2017), and their clinical information was retrospectively collected. Of 40 patients diagnosed with pregnancy-associated cervical cancer at ≥22 gestational weeks, 34 (85.0%) were carefully followed until delivery without intervention. Of 163 diagnosed at &lt;22 gestational weeks, 111 continued and 52 terminated their pregnancy. Ninety patients with stage IB1 disease had various treatment options, including termination of pregnancy. The 59 stage IB1 patients who continued their pregnancy were categorized by the primary treatment into strict follow-up, conization, trachelectomy, and neoadjuvant chemotherapy groups, with no significant differences in progression-free or overall survival. The birth weight percentile at delivery was smaller in the neoadjuvant chemotherapy group than in the strict follow-up group (p = 0.029). Full-term delivery rate was relatively higher in the trachelectomy group (35%) than in the other groups. Treatment decisions for pregnancy-associated cervical cancer are needed after estimating the stage, considering both maternal and fetal benefits.

    DOI: 10.3390/cancers14133072

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  • Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activity. 国際誌

    Risa Kudo, Masayuki Sekine, Manako Yamaguchi, Megumi Hara, Sharon J B Hanley, Megumi Kurosawa, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

    Cancer science   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Japanese girls aged 12-16 years are offered free human papillomavirus (HPV) vaccination and cervical cancer screening is conducted with cytology and not HPV testing from the age of 20 years. So far, no study has analyzed the effect of HPV vaccination against cervical precancers considering HPV infection status and sexual activity. We aimed to analyze the vaccine effectiveness (VE) against HPV infection and cytological abnormalities, adjusted for sexual activity. This study comprised women aged 20-26 years who underwent cervical screening in Niigata. We obtained HPV vaccination status from municipal records and a questionnaire along with information concerning sexual activity. Of 5194 women registered for this study, final analyses included 3167 women in the vaccinated group (2821 vaccinated women prior to sexual debut) and 1386 women in the unvaccinated group. HPV 16/18 (0.2% vs 3.5%), 31/45/52 (3.4% vs 6.6%), and 31/33/45/52/58 (5.0% vs 9.3%) positive rates were significantly lower in the vaccinated group (P < 0.001). No women vaccinated before sexual debut had HPV 16/18-related cytological abnormalities. VE for HPV 16/18 infection and high-grade cytological abnormalities in women vaccinated prior to sexual debut were 95.8% (95% CI 81.9-99.0%; P < 0.001) and 78.3% (95% CI 11.3-94.7%; P = 0.033), respectively, in multivariate analyses adjusted for age and number of sexual partners. However, analyses of all vaccinated women did not show significant effectiveness against cytological abnormalities. Our results showed the effectiveness of HPV vaccine against high-grade cervical cytological abnormalities and the importance of the vaccination before sexual debut.

    DOI: 10.1111/cas.15471

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  • 【HPVワクチンのこれまでとこれから-国際的評価を踏まえた課題-】日本の動向と今後の課題 HPVワクチン有効性のエビデンス 新潟スタディ

    工藤 梨沙, 関根 正幸, 榎本 隆之

    産科と婦人科   89 ( 6 )   623 - 627   2022年6月

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    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    AMED榎本班として新潟大学で実施しているNIIGATA STUDYは、子宮頸がん検診時にHPV検査とアンケート調査をあわせて行う横断研究である。自治体記録による正確なHPVワクチン接種歴を用いることと、アンケートによる性的活動性の情報を用いた多変量解析を行っていることが強みである。これまでに20〜22歳を対象にして、HPV16/18型感染に加えて、2価HPVワクチンはHPV31/45/52型感染に対する予防効果を示し、その効果が25〜26歳時点(ワクチン接種から約9年後)も持続していることを確認した。積極的勧奨中止の影響により、ワクチン接種率が激減した学年では、いったんは低下したHPV16/18型感染率が再上昇を認めていることも最近報告した。(著者抄録)

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  • Treatment specialty-specific characteristics and outcomes in women with vulvo-vaginal melanoma: A JGOG-JSCS joint study. 国際誌

    Koji Matsuo, Shin Nishio, Dai Ogata, Tomoyasu Kato, Motoki Matsuura, Mikio Mikami, Takayuki Enomoto

    Journal of surgical oncology   125 ( 8 )   1333 - 1337   2022年6月

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    記述言語:英語  

    DOI: 10.1002/jso.26835

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  • The Effect of a Web-Based Cervical Cancer Survivor's Story on Parents' Behavior and Willingness to Consider Human Papillomavirus Vaccination for Daughters: Randomized Controlled Trial. 国際誌

    Yukio Suzuki, Akiko Sukegawa, Yutaka Ueda, Masayuki Sekine, Takayuki Enomoto, Alexander Melamed, Jason D Wright, Etsuko Miyagi

    JMIR public health and surveillance   8 ( 5 )   e34715   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Providing adequate information to parents who have children eligible for human papillomavirus (HPV) vaccination is essential to overcoming vaccine hesitancy in Japan, where the government recommendation has been suspended. However, prior trials assessing the effect of brief educational tools have shown only limited effects on increasing the willingness of parents to vaccinate their daughters. OBJECTIVE: The aim of this trial is to assess the effect of a cervical cancer survivor's story on the willingness of parents to get HPV vaccination for their daughters. METHODS: In this double-blinded, randomized controlled trial (RCT) implemented online, we enrolled 2175 participants aged 30-59 years in March 2020 via a webpage and provided them with a questionnaire related to the following aspects: awareness regarding HPV infection and HPV vaccination, and willingness for HPV vaccination. Participants were randomly assigned (1:1) to see a short film on a cervical cancer survivor or nothing, stratified by sex (male vs female) and willingness for HPV vaccination prior to randomization (yes vs no). The primary endpoint was the rate of parents who agreed for HPV vaccination for their daughters. The secondary endpoint was the rate of parents who agreed for HPV vaccination for their daughters and the HPV vaccination rate at 3 months. The risk ratio (RR) was used to assess the interventional effect. RESULTS: Of 2175 participants, 1266 (58.2%) were men and 909 (41.8%) were women. A total of 191 (8.8%) participants were willing to consider HPV vaccination prior to randomization. Only 339 (15.6%) participants were aware of the benefits of HPV vaccination. In contrast, 562 (25.8%) participants were aware of the adverse events of HPV vaccination. Although only 476 (21.9%) of the respondents displayed a willingness to vaccinate their daughters for HPV, there were 7.5% more respondents in the intervention group with this willingness immediately after watching the short film (RR 1.41, 95% CI 1.20-1.66). In a subanalysis, the willingness in males to vaccinate daughters was significantly higher in the intervention group (RR 1.50, 95% CI 1.25-1.81); however, such a difference was not observed among females (RR 1.21, 95% CI 0.88-1.66). In the follow-up survey at 3 months, 1807 (83.1%) participants responded. Of these, 149 (8.2%) responded that they had had their daughters receive vaccination during the 3 months, even though we could not see the effect of the intervention: 77 (7.9%) in the intervention group and 72 (8.7%) in the control group. CONCLUSIONS: A cervical cancer survivor's story increases immediate willingness to consider HPV vaccination, but the effect does not last for 3 months. Furthermore, this narrative approach to parents does not increase vaccination rates in children eligible for HPV vaccination. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000039273; https://tinyurl.com/bdzjp4yf.

    DOI: 10.2196/34715

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  • Phase II study of niraparib in recurrent or persistent rare fraction of gynecologic malignancies with homologous recombination deficiency (JGOG2052). 国際誌

    Hiroshi Asano, Katsutoshi Oda, Kosuke Yoshihara, Yoichi M Ito, Noriomi Matsumura, Muneaki Shimada, Hidemichi Watari, Takayuki Enomoto

    Journal of gynecologic oncology   33 ( 4 )   e55   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Poly (adenosine diphosphate)-ribose polymerase (PARP) inhibitors for tumors with homologous recombination deficiency (HRD), including pathogenic mutations in BRCA1/2, have been developed. Genomic analysis revealed that about 20% of uterine leiomyosarcoma (uLMS) have HRD, including 7.5%-10% of BRCA1/2 alterations and 4%-6% of carcinomas of the uterine corpus, and 2.5%-4% of the uterine cervix have alterations of BRCA1/2. Preclinical and clinical case reports suggest that PARP inhibitors may be effective against those targets. The Japanese Gynecologic Oncology Group (JGOG) is now planning to conduct a new investigator-initiated clinical trial, JGOG2052. METHODS: JGOG2052 is a single-arm, open-label, multi-center, phase 2 clinical trial to evaluate the efficacy and safety of niraparib monotherapy for a recurrent or persistent rare fraction of gynecologic malignancies with BRCA1/2 mutations except for ovarian cancers. We will independently consider the effect of niraparib for uLMS or other gynecologic malignancies with BRCA1/2 mutations (cohort A, C) and HRD positive uLMS without BRCA1/2 mutations (cohort B). Participants must have 1-3 lines of previous chemotherapy and at least one measurable lesion according to RECIST (v.1.1). Niraparib will be orally administered once a day until lesion exacerbation or unacceptable adverse events occur. Efficacy will be evaluated by imaging through an additional computed tomography scan every 8 weeks. Safety will be measured weekly in cycle 1 and every 4 weeks after cycle 2 by blood tests and physical examinations. The sample size is 16-20 in each of cohort A and B, and 31 in cohort C. Primary endpoint is the objective response rate. TRIAL REGISTRATION: Japan Primary Registries Network (JPRN) Identifier: jRCT2031210264.

    DOI: 10.3802/jgo.2022.33.e55

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  • Correlation between the risk of ovarian cancer and BRCA recurrent pathogenic variants in Japan. 国際誌

    Masayuki Sekine, Takayuki Enomoto, Masami Arai, Shiro Yokoyama, Hiroyuki Nomura, Koji Nishino, Takeshi Ikeuchi, Yoko Kuriyama, Seigo Nakamura

    Journal of human genetics   67 ( 5 )   267 - 272   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We previously reported that L63X and Q934X are BRCA1 common founder variants in Japan. So far, there have been no reports of a correlation between such BRCA common variants and the risk of BRCA-related cancers. In this analysis, we investigated the correlation between the risk of ovarian cancer (OC) and BRCA recurrent pathogenic variants. We examined the database of the Japanese organization of hereditary breast and ovarian cancer. The database contained 3517 probands who underwent BRCA genetic testing. Among them, 11.1% (392/3517) had germline BRCA1 pathogenic variant, and 8.3% (293/3517) had BRCA2 pathogenic variant. We calculated the OC prevalence, breast cancer (BC) prevalence, and the ratio of OC to BC within second-degree relatives. The ratio of OC to BC in Q934X family members was significantly higher than that in the overall BRCA1 family members (0.80 vs.0.52: p = 0.038), and the ratio in STOP799 was 0.42, which was relatively lower than the overall BRCA1 value. Both Q934X and STOP799 are located in the ovarian cancer cluster region (OCCR), however there seems to be a difference in the risk of OC. R2318X family members had a significant higher ratio of OC to BC at 0.32 than the overall BRCA2 value of 0.13 (p = 0.012). R2318X is known to be located in the OCCR. This is the first report to investigate the correlation between BRCA recurrent variants and the risk of OC in Japan. The family members of probands with Q934X or R2318X have a higher risk of OC than that with other BRCA variants.

    DOI: 10.1038/s10038-021-01002-z

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  • Surgical skill and oncological outcome of laparoscopic radical hysterectomy: JGOG1081s-A1, an ancillary analysis of the Japanese Gynecologic Oncology Group Study JGOG1081. 国際誌

    Eiji Kobayashi, Eiji Nakatani, Tomohito Tanaka, Kawai Yosuke, Hiroyuki Kanao, Yasuhiko Shiki, Yasushi Kotani, Tsutomu Hoshiba, Rie Minami, Hiroshi Yoshida, Satoru Kyo, Masae Yorimitsu, Tsuyoshi Yamashita, Tetsuya Hasegawa, Toshiaki Matsuura, Seiji Kagami, Toru Fujioka, Tanaka Hirohiko, Shin Nishio, Munetaka Takekuma, Mikio Mikami, Takayuki Enomoto

    Gynecologic oncology   165 ( 2 )   293 - 301   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: We investigated whether surgical skill and procedure were related to oncological outcomes in cervical cancer patients who underwent Laparoscopic Radical Hysterectomy (LRH). METHODS: We previously assessed data of LRH from 251 patients with FIGO stage (2009) IA2, IB1and IIA1 cervical cancer collected for JGOG 1081s study. 1) The JGOG 1081s cohort study was re-examined to refine the surgical details and extend the follow-up period as chart review. 2) Unedited videos for recurrent cases and matched non-recurrent control cases were newly compared by experts for various surgical skills and surgical procedures using the modified Objective Structured Assessment of Technical Skills (OSATS) tool, without awareness of the recurrence status as video review. RESULTS: After a median follow-up of 46 months, tumors had recurred in 31 of the 251 patients. The five-year Recurrence-Free Survival rate was 86.9% (81.8-90.6) and five-year Overall Survival rate was 93.7% (87.5-96.8). Multivariate analysis from chart reviews found that an experience with LRH of less than 20 cases per institution was an independent prognostic factor for recurrence (Hazard Ratio (HR) 2.49, 95%CI 1.12-5.53, p = 0.025). For the surgical video review, we compared 23 videos of recurrent cases with 23 background-matched non-recurrent controls. Lower modified OSATS scores from the video review were consistently trended to have a higher risk of recurrence. CONCLUSIONS: Our new study has found that LRH surgical experience and skill trended to have better oncological outcomes.

    DOI: 10.1016/j.ygyno.2022.02.005

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  • Challenges facing workstyle reform for Japanese obstetricians and gynecologists revealed from time studies. 国際誌

    Masayuki Sekine, Koji Nishijima, Satoshi Nakagawa, Yukio Suzuki, Takashi Murakami, Yasuhito Kato, Takeshi Umazume, Hiroaki Tanaka, Hiroaki Komatsu, Koutaro Doi, Kiyonori Miura, Yoshiki Kudo, Nobuya Unno, Tadashi Kimura, Takayuki Enomoto

    The journal of obstetrics and gynaecology research   48 ( 7 )   1580 - 1590   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: We aimed to grasp the actual working hours of Japanese obstetricians and gynecologists (OB/GYN doctors) as accurately as possible, using the same method of the Ministry of Health, Labour, and Welfare (MHLW). METHODS: The time study targeted OB/GYN doctors working at 10 universities nationwide including Niigata University and 21 institutions which take a role of perinatal care in Niigata prefecture. Working hours per week were calculated based on the following categories: regular and overtime work inside the hospital, work outside the hospital, self-improvement, education, research, and others. Data on weekly working hours were converted to yearly data for analyses. RESULTS: A time study of 10 universities nationwide revealed that 30% of doctors work overtime for more than 1860 h even if they do not include on-call shifts in their working hours. In 21 institutions in Niigata, physicians in Niigata University worked more overtime than other hospitals. It became clear that community health care was supported by dispatching physicians working at university. Furthermore, the results of simulations predicted the pessimistic situation of perinatal medical care in Niigata. CONCLUSIONS: Our study showed the possibility to exist much more OB/GYN doctors who work more than 1860 h of overtime work per year than the data presented by the MHLW based on nation-wide survey in 2019. The fact that the working hours at the side jobs had a great influence on the increase in overtime work of physicians in University was the same result as the report of MHLW published in 2021.

    DOI: 10.1111/jog.15230

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  • 【がん遺伝子検査に基づく婦人科がん治療-最前線のレジメン選択法を理解する】遺伝子診断 BRCA遺伝学的検査とはどのような検査か,何がわかるか

    西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    臨床婦人科産科   76 ( 3 )   317 - 322   2022年4月

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    記述言語:日本語   出版者・発行元:(株)医学書院  

    <文献概要>●卵巣がんに対するBRCA遺伝学的検査は,その目的により(1)PARP阻害薬適応判断のためのコンパニオン検査,(2)遺伝性乳がん卵巣がん(HBOC)を診断するための検査,に大別される.●卵巣がんの約15%はHBOCであり,その診断を目的としたBRCA遺伝学的検査は,すべての卵巣がんに対して保険診療として実施可能である.●BRCA遺伝学的検査により,発端者へのPARP阻害薬による治療や,がん未発症家系員へのサーベイランス・リスク低減手術の提供が可能となる場合があり,卵巣がん全例に対する検査実施を考慮すべきである.

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  • Long-term effectiveness of HPV vaccination against HPV infection in young Japanese women: Real-world data. 国際誌

    Megumi Kurosawa, Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J B Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

    Cancer science   113 ( 4 )   1435 - 1440   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In Japan, public funding for HPV vaccination began in 2010 for girls aged 13-16 years (birth cohort years 1994-1997) and women born in 1994 who turned 25 in 2019. We aimed to verify the long-term effectiveness of the bivalent HPV vaccine in women aged 25 years. Subjects were women aged 25-26 years who underwent cervical cancer screening and HPV testing in Niigata from 2019 to 2020 (birth cohort years 1993-1994). Information on vaccination status and sexual behavior was obtained from a questionnaire and municipal records. We compared the HPV infection rates of the vaccinated and unvaccinated groups. Of the 429 registrants, 150 (35.0%) and 279 (65.0%) were vaccinated and unvaccinated, respectively. The average period from HPV vaccination to HPV testing was 102.7 months (8.6 years), with a median of 103 months (range 92-109 months). The HPV high-risk infection rate was 21.3% (32/150) in the vaccinated group and 23.7% (66/279) in the unvaccinated group (P = 0.63). The HPV16/18 infection rate was 0% (0/150) in the vaccinated group and 5.4% (15/279) in the unvaccinated group, showing a significant difference (P = 0.0018), and the vaccine effectiveness was 100%. The cross-protective type HPV31/45/52 infection rate in the vaccinated group was significantly lower than that in the unvaccinated group (3.3% vs. 10.0%, P = 0.013). There was no significant difference in the mean age at sexual debut and the number of previous sexual partners between the two groups. We have demonstrated the long-term 9-year effectiveness of the bivalent vaccine against HPV infection for the first time in Japan.

    DOI: 10.1111/cas.15282

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  • Differences in age at diagnosis of ovarian cancer for each BRCA mutation type in Japan: optimal timing to carry out risk-reducing salpingo-oophorectomy. 国際誌

    Masayuki Sekine, Takayuki Enomoto, Masami Arai, Hiroki Den, Hiroyuki Nomura, Takeshi Ikeuchi, Seigo Nakamura

    Journal of gynecologic oncology   33 ( 4 )   e46   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: BRCA1 and BRCA2 mutation carriers are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) by age 40 and 45, respectively. However, the carriers have a different way of thinking about their life plan. We aimed to investigate the distribution of age at diagnosis of ovarian cancer (OC) patients to examine the optimal timing of RRSO in the carriers. METHODS: We examined a correlation between age at diagnosis of OC and common mutation types in 3,517 probands that received BRCA genetic testing. Among them, germline BRCA1 mutation (gBRCA1m), germline BRCA2 mutation (gBRCA2m) and germline BRCA wild-type (gBRCAwt) were found in 185, 42 and 241 OC patients, respectively. RESULTS: The average age at diagnosis of OC in gBRCA1m and gBRCA2m was 51.3 and 58.3 years, respectively, and the difference from gBRCAwt (53.8 years) was significant. The gBRCA2m carriers did not develop OC under the age of 40. The average age was 50.1 years for L63X and 52.8 years for Q934X in BRCA1, and 55.1 years for R2318X and 61.1 years for STOP1861 in BRCA2. The age at diagnosis in L63X or R2318X carriers was relatively younger than other BRCA1 or BRCA2 carriers, however their differences were not significant. With L63X and R2318X carriers, 89.4% (42/47) and 100% (7/7) of women were able to prevent the development of OC, respectively, when RRSO was performed at age 40. CONCLUSION: There appears to be no difference in the age at diagnosis of OC depending on the type of BRCA common mutation. Further analysis would be needed.

    DOI: 10.3802/jgo.2022.33.e46

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  • Massive ascites due to lupus peritonitis in a patient with pre-eclampsia and systemic lupus erythematosus: a case report. 国際誌

    Shunya Sugai, Kazuaki Suda, Kana Tamegai, Kazufumi Haino, Takeshi Nakatsue, Ichiei Narita, Takayuki Enomoto, Koji Nishijima

    BMC pregnancy and childbirth   22 ( 1 )   203 - 203   2022年3月

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    記述言語:英語  

    BACKGROUND: Patients with systemic lupus erythematosus (SLE) are associated with pre-eclampsia. Pre-eclampsia can have systemic manifestations, such as ascites. Lupus peritonitis, a rare condition in patients with SLE, can also cause ascites. CASE PRESENTATION: A 31-year-old woman, primigravida, with SLE had a blood pressure of 170/110 mmHg and proteinuria at 29 weeks of gestation. She was diagnosed with pre-eclampsia. Her blood pressure was stabilized by an antihypertensive drug. At 30 weeks of gestation, a cesarean section was performed for maternal safety because of decreased urine output and massive ascites. Postoperatively, re-accumulation of ascites was observed. On the fourth postoperative day, ascites (approximately 3 L) was discharged from the cesarean section wound. A decrease in serum complement concentrations was observed, and she was diagnosed as having lupus peritonitis. The steroid dose was increased and she recovered well thereafter. CONCLUSIONS: Ascites occurs in pre-eclampsia and SLE, but determining which of these conditions causes ascites can be difficult. However, careful observation is necessary because of the differences in treatment of these two conditions.

    DOI: 10.1186/s12884-022-04550-0

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  • HPVワクチン積極的勧奨再開へ向けて

    工藤 梨沙, 関根 正幸, 黒澤 めぐみ, 山口 真奈子, 安達 聡介, 榎本 隆之

    新潟県医師会報   ( 864 )   10 - 15   2022年3月

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    記述言語:日本語   出版者・発行元:新潟県医師会  

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  • Survival and reproductive outcomes after fertility-sparing surgery performed for borderline epithelial ovarian tumor in Japanese adolescents and young adults: Results of a retrospective nationwide study. 国際誌

    Shiho Kuji, Miyuki Harada, Norihito Yoshioka, Hiroaki Kajiyama, Toyomi Satoh, Mikio Mikami, Makio Shozu, Takayuki Enomoto, Yutaka Osuga, Nao Suzuki

    The journal of obstetrics and gynaecology research   48 ( 3 )   806 - 816   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Epithelial borderline ovarian tumor (BOT) frequently occurs in young women. Because progression-free survival, overall survival, and reproductive function are important outcomes, BOT is often treated by fertility-sparing surgery (FSS). We conducted a Japan-wide study to understand post-FSS prognosis in relation to clinical characteristics and types of FSS performed. METHODS: We analyzed clinical and outcome data pertaining to 531 adolescent and young adult (AYA) patients (aged 15-39 years) who underwent FSS for BOT between 2009 and 2013. RESULTS: Median (range) age was 30 (15-39) years, and median observation time was 70 (2-120) months. The disease was of FIGO stage I in 492 (93%) patients. Histopathologically, tumors were of the mucinous (n = 372, 70%), serous (n = 120, 23%), seromucinous (n = 23, 4%), and other (n = 16, 3%) types. Five-year overall survival was 99.5% among patients with stage I and 100% among those with stage II-IV. Five-year progression-free survival was 96.7% and 69.3%, respectively. Multivariate analysis in cases of stage I showed a positive peritoneal cytology to be a significant risk factor for recurrence (HR, 5.199; p = 0.0188). The post-FSS pregnancy rate was relatively low for patients aged ≥30 years (OR, 0.868; 95% CI, 1.16-3.00; p = 0.0090). CONCLUSION: Post-FFS outcomes in terms of overall and progression-free survival are favorable, especially for AYA patients with stage I BOT. However, the relapse rate is high for patients with FIGO stage II-IV and for those with stage I but a positive peritoneal cytology. A long-term prospective observation is needed before reproductive outcomes can be fully established.

    DOI: 10.1111/jog.15131

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  • Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium. 国際誌

    Manako Yamaguchi, Hirofumi Nakaoka, Kazuaki Suda, Kosuke Yoshihara, Tatsuya Ishiguro, Nozomi Yachida, Kyota Saito, Haruka Ueda, Kentaro Sugino, Yutaro Mori, Kaoru Yamawaki, Ryo Tamura, Sundaramoorthy Revathidevi, Teiichi Motoyama, Kazuki Tainaka, Roel G W Verhaak, Ituro Inoue, Takayuki Enomoto

    Nature communications   13 ( 1 )   943 - 943   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It has become evident that somatic mutations in cancer-associated genes accumulate in the normal endometrium, but spatiotemporal understanding of the evolution and expansion of mutant clones is limited. To elucidate the timing and mechanism of the clonal expansion of somatic mutations in cancer-associated genes in the normal endometrium, we sequence 1311 endometrial glands from 37 women. By collecting endometrial glands from different parts of the endometrium, we show that multiple glands with the same somatic mutations occupy substantial areas of the endometrium. We demonstrate that "rhizome structures", in which the basal glands run horizontally along the muscular layer and multiple vertical glands rise from the basal gland, originate from the same ancestral clone. Moreover, mutant clones detected in the vertical glands diversify by acquiring additional mutations. These results suggest that clonal expansions through the rhizome structures are involved in the mechanism by which mutant clones extend their territories. Furthermore, we show clonal expansions and copy neutral loss-of-heterozygosity events occur early in life, suggesting such events can be tolerated many years in the normal endometrium. Our results of the evolutionary dynamics of mutant clones in the human endometrium will lead to a better understanding of the mechanisms of endometrial regeneration during the menstrual cycle and the development of therapies for the prevention and treatment of endometrium-related diseases.

    DOI: 10.1038/s41467-022-28568-2

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  • Long-Term Effects of Human Papillomavirus Vaccination in Clinical Trials and Real-World Data: A Systematic Review. 国際誌

    Megumi Kurosawa, Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J B Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

    Vaccines   10 ( 2 )   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The preventive effect of HPV vaccines against anogenital and oropharyngeal cancers has been proven in both clinical trials and real-world data. We reviewed the published evidence about the long-term efficacy and effectiveness of the HPV vaccine in available papers of clinical trials and real-world data. As far as we searched, the longest period of preventive effect for the bivalent, 4-valent, and 9-valent vaccine were 11 years in the Costa Rica trial, 14 years in the FUTURE II, and 8 years in the LTFU extension study of V503-002 and the Scandinavian study, respectively. The sustained clinical effect during the observation period was longest for the 4-valent vaccine. In real-world data, the longest observation period of the vaccine effectiveness was 12 years in an Australian study for the 4-valent vaccine. On the other hand, the longest period of long-term persistence of HPV vaccine-induced seropositivity was 14 years in FUTURE II for the 4-valent vaccine. For the bivalent vaccine, additional long-term follow-up studies may not have been planned due to the launch of the 4-valent and 9-valent vaccines. In some studies of the 9-valent vaccine, the results have not yet been published because of the short observation period. The additional results are expected in the future. In a national immunization program, most girls and boys are inoculated with HPV vaccine by the time puberty begins; thus, it is important to monitor the vaccine effect at least until the sexually active period in their 20s and 30s.

    DOI: 10.3390/vaccines10020256

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  • An artificial intelligence-assisted diagnostic system improves the accuracy of image diagnosis of uterine cervical lesions. 国際誌

    Yu Ito, Ai Miyoshi, Yutaka Ueda, Yusuke Tanaka, Ruriko Nakae, Akiko Morimoto, Mayu Shiomi, Takayuki Enomoto, Masayuki Sekine, Toshiyuki Sasagawa, Kiyoshi Yoshino, Hiroshi Harada, Takafumi Nakamura, Takuya Murata, Keizo Hiramatsu, Junko Saito, Junko Yagi, Yoshiaki Tanaka, Tadashi Kimura

    Molecular and clinical oncology   16 ( 2 )   27 - 27   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The present study created an artificial intelligence (AI)-automated diagnostics system for uterine cervical lesions and assessed the performance of these images for AI diagnostic imaging of pathological cervical lesions. A total of 463 colposcopic images were analyzed. The traditional colposcopy diagnoses were compared to those obtained by AI image diagnosis. Next, 100 images were presented to a panel of 32 gynecologists who independently examined each image in a blinded fashion and diagnosed them for four categories of tumors. Then, the 32 gynecologists revisited their diagnosis for each image after being informed of the AI diagnosis. The present study assessed any changes in physician diagnosis and the accuracy of AI-image-assisted diagnosis (AISD). The accuracy of AI was 57.8% for normal, 35.4% for cervical intraepithelial neoplasia (CIN)1, 40.5% for CIN2-3 and 44.2% for invasive cancer. The accuracy of gynecologist diagnoses from cervical pathological images, before knowing the AI image diagnosis, was 54.4% for CIN2-3 and 38.9% for invasive cancer. After learning of the AISD, their accuracy improved to 58.0% for CIN2-3 and 48.5% for invasive cancer. AI-assisted image diagnosis was able to improve gynecologist diagnosis accuracy significantly (P<0.01) for invasive cancer and tended to improve their accuracy for CIN2-3 (P=0.14).

    DOI: 10.3892/mco.2021.2460

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  • 【婦人科疾患合併妊娠まるごと図解 イチから学ぶ病態生理〜妊娠・分娩管理】トピックス HPVワクチンの最新の話題

    工藤 梨沙, 関根 正幸, 榎本 隆之

    ペリネイタルケア   41 ( 2 )   173 - 177   2022年2月

  • 【婦人科疾患合併妊娠まるごと図解 イチから学ぶ病態生理〜妊娠・分娩管理】トピックス HPVワクチンの最新の話題

    工藤 梨沙, 関根 正幸, 榎本 隆之

    ペリネイタルケア   41 ( 2 )   173 - 177   2022年2月

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    記述言語:日本語   出版者・発行元:(株)メディカ出版  

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  • APOBEC mediated mutagenesis drives genomic heterogeneity in endometriosis

    Sundaramoorthy Revathidevi, Hirofumi Nakaoka, Kazuaki Suda, Naoko Fujito, Arasambattu Kannan Munirajan, Kosuke Yoshihara, Takayuki Enomoto, Ituro Inoue

    Journal of Human Genetics   2022年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1038/s10038-021-01003-y

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    その他リンク: https://www.nature.com/articles/s10038-021-01003-y

  • The looming health hazard: A wave of HPV-related cancers in Japan is becoming a reality due to the continued suspension of the governmental recommendation of HPV vaccine. 国際誌

    Asami Yagi, Yutaka Ueda, Sayaka Ikeda, Etsuko Miyagi, Masayuki Sekine, Takayuki Enomoto, Tadashi Kimura

    The Lancet regional health. Western Pacific   18   100327 - 100327   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lanwpc.2021.100327

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  • Cellular and Humoral Immune Responses Induced by an HLA Class I–restricted Peptide Cancer Vaccine Targeting WT1 Are Associated With Favorable Clinical Outcomes in Advanced Ovarian Cancer 査読 国際誌

    Sumiyuki Nishida, Soyoko Morimoto, Yusuke Oji, Satoshi Morita, Toshiaki Shirakata, Takayuki Enomoto, Akihiro Tsuboi, Yutaka Ueda, Kiyoshi Yoshino, Alzaaqi Shouq, Mizuki Kanegae, Satoshi Ohno, Fumihiro Fujiki, Hiroko Nakajima, Yoshiki Nakae, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Tadashi Kimura, Haruo Sugiyama

    Journal of Immunotherapy   45 ( 1 )   56 - 66   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    The HLA-A*24:02-restricted peptide vaccine targeting Wilms' tumor 1 (WT1) (WT1 vaccine) is a promising therapeutic strategy for ovarian cancer; however, its efficacy varies among patients. In this study, we analyzed WT1-specific immune responses in patients with advanced or recurrent ovarian cancer that was refractory to standard chemotherapies and their associations with clinical outcomes. In 25 patients, the WT1 vaccine was administered subcutaneously weekly for 3 months and biweekly thereafter until disease progression or severe adverse events. We assessed Wilms' tumor 1-specific cytotoxic T lymphocytes (WT1-CTLs) and Wilms' tumor 1 peptide-specific immunoglobulin G (WT1235-IgG). After vaccination, the percentage of tetramer high-avidity population of WT1-CTLs among CD8+ T lymphocytes (%tet-hi WT1-CTL) and the WT1235-IgG titer increased significantly, although the values were extremely low or below the limit of detection before vaccination (%tet-hi WT1-CTL: 0.003%-0.103%.; WT1235-IgG: <0.05-0.077 U/mL). Patients who had %tet-hi WT1-CTL of ≥0.25% (n=6) or WT1235-IgG of ≥0.10 U/mL (n=12) had a significantly longer progression-free survival than those of patients in the other groups. In addition, an increase in WT1235-IgG corresponded to a significantly longer progression-free survival (P=0.0496). In patients with systemic inflammation, as evidenced by elevated C-reactive protein levels, the induction of tet-hi WT1-CTL or WT1235-IgG was insufficient. Decreased serum albumin levels, multiple tumor lesions, poor performance status, and excess ascites negatively influenced the clinical effectiveness of the WT1 vaccine. In conclusion, the WT1 vaccine induced antigen-specific cellular and humoral immunity in patients with refractory ovarian cancer. Both %tet-hi WT1-CTL and WT1235-IgG levels are prognostic markers for the WT1 vaccine.

    DOI: 10.1097/cji.0000000000000405

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  • HPVワクチンの積極的勧奨差し控えによって上昇した2000年度生まれの子宮頸部細胞診異常率

    八木 麻未, 上田 豊, 池田 さやか, 宮城 悦子, 関根 正幸, 榎本 隆之, 木村 正

    Journal of Epidemiology   32 ( Suppl.1 )   106 - 106   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 【遺伝性腫瘍学入門 遺伝性腫瘍の基礎知識】疾患各論 HBOC 卵巣癌に対するHBOCの診断と治療

    関根 正幸, 西野 幸治, 榎本 隆之

    遺伝子医学   別冊 ( 遺伝性腫瘍の基礎知識 )   108 - 112   2022年1月

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    記述言語:日本語   出版者・発行元:(株)メディカルドゥ  

    卵巣癌に対するゲノム医療は,BRCA1/2遺伝子の生殖細胞系列病的バリアント(gBRCAm)を原因とする遺伝性乳癌卵巣癌(hereditary breast and ovarian cancer:HBOC)を主な対象として行われた臨床試験により,PARP阻害薬の有効性が証明され大きく変貌を遂げた。PARP阻害薬は,今では臓器横断的に相同組換え修復異常(homologous recombination deficiency:HRD)を示すがんに対して有効性が示されている。再発卵巣癌の維持療法においては,PARP阻害薬の感受性を予測する臨床的なサロゲートマーカーとしてプラチナ感受性が用いられ,さらに初回治療における維持療法を中心としたコンパニオン診断としてgBRCA1/2遺伝子検査と腫瘍におけるMyriad myChoice HRD検査が保険適応となった。さらに,HBOCの乳癌あるいは卵巣癌患者に対する予防診療が2020年4月より保険収載され,HBOCに対する診断と治療が日々変化している状況となっている。本稿ではHBOCの卵巣癌患者をターゲットとしたゲノム医療と,ゲノム情報に基づく先制医療の現状と展望について解説する。(著者抄録)

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  • Association between hospital treatment volume and survival of women with gynecologic malignancy in Japan: a JSOG tumor registry-based data extraction study. 国際誌

    Hiroko Machida, Koji Matsuo, Koji Oba, Daisuke Aoki, Takayuki Enomoto, Aikou Okamoto, Hidetaka Katabuchi, Satoru Nagase, Masaki Mandai, Nobuo Yaegashi, Wataru Yamagami, Mikio Mikami

    Journal of gynecologic oncology   33 ( 1 )   e3   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Associations between hospital treatment volume and survival outcomes for women with 3 types of gynecologic malignancies, and the trends and contributing factors for high-volume centers were examined. METHODS: The Japan Society of Obstetrics and Gynecology tumor registry databased retrospective study examined 206,845 women with 80,741, 73,647, and 52,457 of endometrial, cervical, and ovarian tumor, respectively, who underwent primary treatment in Japan between 2004 and 2015. Associations between the annual treatment volume and overall survival (OS) for each tumor type were examined using a multivariable Cox proportional hazards model with restricted cubic splines. Institutions were categorized into 3 groups (low-, moderate-, and high-volume centers) based on hazard risks. RESULTS: Hazard ratio (HR) for OS each the 3 tumors decreased with hospital treatment volume. The cut-off points of treatment volume were defined for high- (≥50, ≥51, and ≥27), moderate- (20-49, 20-50, and 17-26), and low-volume centers (≤19, ≤19, and ≤16) by cases/year for endometrial, cervical, and ovarian tumors, respectively. Multivariate analysis revealed younger age, rare tumor histology, and initial surgical management as contributing factors for women at high-volume centers (all, p<0.001). The proportion of high-volume center treatments decreased, whereas low-volume center treatments increased (all p<0.001). Treatment at high-volume centers improved OS than that at other centers (adjusted HR [aHR]=0.83, 95% confidence interval [CI]=0.78-0.88; aHR=0.78, 95% CI=0.75-0.83; and aHR=0.90, 95% CI=0.86-0.95 for endometrial, cervical, and ovarian tumors). CONCLUSION: Hospital treatment volume impacted survival outcomes. Treatments at high-volume centers conferred survival benefits for women with gynecologic malignancies. The proportion of treatments at high-volume centers have been decreasing recently.

    DOI: 10.3802/jgo.2022.33.e3

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  • 【産婦人科医が知っておきたい臨床遺伝学のすべて】腫瘍 HBOCに対応するための知識 遺伝性疾患としての病態,診断法,治療ないし対応法と説明の際の留意点

    西野 幸治, 関根 正幸, 榎本 隆之

    臨床婦人科産科   76 ( 1 )   88 - 95   2022年1月

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    記述言語:日本語   出版者・発行元:(株)医学書院  

    <文献概要>●卵巣がんの約15%は遺伝性乳がん卵巣がん(HBOC)である.HBOCを診断することのベネフィットは大きく,卵巣がん全例に対してBRCA遺伝学的検査の実施を考慮すべきである.●HBOCは,診断法や病的バリアント保持者に対する対応(サーベイランス・リスク低減手術など)が定まっている数少ない遺伝性疾患の1つである.●HBOCを診断することは,発端者へのPARP阻害薬による治療のみならず,家系員のバリアント保持者の診断やサーベイランス・リスク低減手術の提供を可能とし,健康維持に大きく貢献する.

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  • HPVワクチンの積極的勧奨差し控えによって上昇した2000年度生まれの子宮頸部細胞診異常率

    八木 麻未, 上田 豊, 池田 さやか, 宮城 悦子, 関根 正幸, 榎本 隆之, 木村 正

    Journal of Epidemiology   32 ( Suppl.1 )   106 - 106   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 当院における進行・再発卵巣癌・卵管癌・腹膜癌に対するBevacizumabの有害事象に関する検討

    新井 龍寿, 西川 伸道, 明石 絵里菜, 鈴木 美保, 安達 聡介, 吉原 弘祐, 西野 幸治, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   116 ( 1 )   25 - 28   2021年12月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    当院でBevacizumab(Bev)を導入した進行・再発卵巣癌・卵管癌・腹膜癌125例を対象に有害事象について検討を行った。その結果、Grade3以上の有害事象として高血圧16例(12.8%)、蛋白尿5例(4.0%)、血栓塞栓症3例(2.4%)、消化管穿孔2例(1.6%)が認められた。消化管穿孔例はともにGrade4で緊急手術を要し、それぞれ腫瘍と直腸癒着・浸潤部分の穿孔、高度癒着部分の穿孔であった。

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  • Cervical Cancer Protection in Japan: Where Are We? 国際誌

    Asami Yagi, Yutaka Ueda, Mamoru Kakuda, Satoshi Nakagawa, Kosuke Hiramatsu, Ai Miyoshi, Eiji Kobayashi, Toshihiro Kimura, Megumi Kurosawa, Manako Yamaguchi, Sosuke Adachi, Risa Kudo, Masayuki Sekine, Yukio Suzuki, Akiko Sukegawa, Sayaka Ikeda, Etsuko Miyagi, Takayuki Enomoto, Tadashi Kimura

    Vaccines   9 ( 11 )   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In Japan, government subsidies for human papillomavirus (HPV) vaccination of girls aged 13-16 commenced in 2010. By early 2013, vaccination had become a widely accepted national immunization program. However, in June of 2013, the Ministry of Health, Labor, and Welfare (MHLW), the government's lead agency, suspended its recommendation for vaccination in response to reports of adverse vaccine events. The rate of HPV vaccination quickly dropped from 70% to almost zero, where it has lingered for eight years. In 2020, a new 9-valent HPV vaccine was licensed in Japan. The momentum seemed to be building for the resumption of HPV vaccinations, yet Japanese mothers remain widely hesitant about vaccinating their daughters, despite the well-proven safety and efficacy of the HPV vaccines. The Japanese government and our educational and medical institutions must work harder as a team to inform our parents and their children about the life-saving benefits of the HPV vaccine, and at the same time, we must respond to all their concerns and questions. The vaccine hesitancy of unvaccinated women born in 2000 and thereafter is a natural consequence of the suspension of the government's recommendation. We must also take every possible measure to reduce the significant risk for cervical cancer these women have.

    DOI: 10.3390/vaccines9111263

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  • Suspension of proactive recommendations for HPV vaccination has led to a significant increase in HPV infection rates in young Japanese women: real-world data

    Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J.B. Hanley, Yutaka Ueda, Sosuke Adachi, Megumi Kurosawa, Etsuko Miyagi, Megumi Hara, Takayuki Enomoto

    The Lancet Regional Health - Western Pacific   16   100300 - 100300   2021年11月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.lanwpc.2021.100300

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  • Correction to: The efficacy and safety profile of 2-weekly dosing of bevacizumab-containing chemotherapy for platinum-resistant recurrent ovarian cancer.

    Masayuki Sekine, Takayuki Enomoto, Yoh Watanabe, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki

    International journal of clinical oncology   26 ( 11 )   2130 - 2130   2021年11月

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  • HPV関連癌(子宮頸癌および中咽頭癌)における診療の現状と予防への展望 子宮頸癌予防におけるHPVワクチン有効性の実証

    関根 正幸, 黒澤 めぐみ, 山口 真奈子, 工藤 梨沙, 安達 聡介, 榎本 隆之

    日本癌治療学会学術集会抄録集   59回   SSY4 - 3   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • Effect of a Brief Web-Based Educational Intervention on Willingness to Consider Human Papillomavirus Vaccination for Children in Japan: Randomized Controlled Trial. 国際誌

    Yukio Suzuki, Akiko Sukegawa, Yutaka Ueda, Masayuki Sekine, Takayuki Enomoto, Etsuko Miyagi

    Journal of medical Internet research   23 ( 9 )   e28355   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The human papillomavirus (HPV) vaccination rate in Japan has fallen to nearly zero since the suspension of governmental proactive recommendations in 2013, owing to the development of purported adverse events. OBJECTIVE: This study aimed to evaluate the effects of a brief web-based educational intervention using the theory of behavioral insights on the willingness of adults to consider the HPV vaccine for their daughters and sons. METHODS: We recruited 1660 participants aged 20 years or older in March 2018 via a webpage and provided them with a 10-item questionnaire related to the following aspects: awareness regarding HPV infection and vaccination, willingness for immunization, and actions for prevention. We randomly stratified participants based on sex and age with or without a brief educational intervention involving scientific information presented in an easy-to-read format. RESULTS: Only 484 (29.2%) of the respondents were aware of the benefits of HPV vaccination. Although only 352 (21.2%) of the respondents displayed a willingness for immunization of their daughters, there were 40 (4.8%) more respondents in the intervention group with this willingness (adjusted odds ratio [aOR] 1.32, 95% CI 1.04-1.69). In a subanalysis, the willingness toward vaccination for daughters in men was significantly higher in the intervention group (aOR 1.46, 95% CI 1.05-2.02). However, such a difference was not observed among women (aOR 1.20, 95% CI 0.83-1.73). CONCLUSIONS: This study suggests that a brief web-based educational intervention increases the willingness of adults to consider the HPV vaccine for their children, especially among men. Thus, providing adequate information to men may be a useful strategy to improve the currently low rates of HPV vaccination. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000049745 (UMIN-CTR); https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049745.

    DOI: 10.2196/28355

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  • Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology. 査読 国際誌

    Masae Ikeda, Mikio Mikami, Miwa Yasaka, Takayuki Enomoto, Yoichi Kobayashi, Satoru Nagase, Masatoshi Yokoyama, Hidetaka Katabuchi

    Journal of gynecologic oncology   32 ( 5 )   e68   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The Japan Society of Obstetrics and Gynecology conducted a retrospective multi-institutional survey of patients who underwent cervical conization in Japan. This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment. METHODS: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demographic characteristics. RESULTS: Negative and positive margins were observed in 7,585 and 1,271 (14.4%) patients, respectively. The predictors of positive margins were menopausal status (p<0.001), loop electrosurgical excision procedure (p<0.001), and Shimodaira-Taniguchi (S-T) conization (p<0.001). Of 1,271 patients with positive margins, 1,060 underwent no additional treatment; among those 1,060 patients, 129 (12.2%) experienced recurrence. The predictors of positive margins in patients who did not undergo additional treatment and did not experience recurrence were age, parity, gravidity, S-T conization, and laser scalpel conization. CONCLUSION: Menopausal status and treatment procedures were associated with positive margins after therapeutic conization of CIN 3. It is important to understand the characteristics of treatment procedures and select an appropriate procedure for each case. For elderly or menopausal patients with positive margins, immediate additional treatment is recommended.

    DOI: 10.3802/jgo.2021.32.e68

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  • Clinicopathological characteristics and prognostic factors of ovarian granulosa cell tumors: A JSGO-JSOG joint study. 国際誌

    Yasuhiko Ebina, Wataru Yamagami, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Mikio Mikami

    Gynecologic oncology   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: The aim of this study was to elucidate the clinicopathological features of ovarian granulosa cell tumors (GCTs) and to identify the prognostic factors. METHODS: The Japanese Society of Gynecologic Oncology (JSGO) conducted an observational retrospective cohort study of women with GCTs enrolled in the Gynecological Tumor Registry of the Japan Society of Obstetrics and Gynecology (JSOG) between 2002 and 2015. Clinicopathological features, including lymph node metastasis, were evaluated. In addition, we performed a prognostic analysis of patients between 2002 and 2011 for whom survival data were available. Kaplan-Meier and multivariate Cox proportional hazards analyses were performed. RESULTS: We identified 1426 patients with GCTs. Of the 222 patients who underwent lymph node dissection, 10 (4.5%) had lymph node metastasis. The incidence of lymph node metastasis in patients with pT1, pT2, and pT3 was 2.1%, 13.3%, and 26.7%, respectively (p < 0.001). Prognostic analysis was performed on 674 patients. In the multivariate Cox regression analysis, residual disease after initial surgery (hazard ratio (HR) = 10.39, 95% confidence interval (CI) = 3.15-34.29) and lymph node metastasis (HR = 5.58, 95% CI = 1.62-19.19) were independent risk factors for cancer-specific survival. CONCLUSIONS: In the initial surgery for GCTs, lymph node dissection can be omitted if the operative finding is pT1. In cases of pT2 or higher, lymph node dissection should be considered. Debulking is critical for achieving no gross residual tumor at the end of the surgery.

    DOI: 10.1016/j.ygyno.2021.08.012

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  • Surveillance of radical hysterectomy for early-stage cervical cancer in the early experienced period of minimally invasive surgery in Japan.

    Tsuyoshi Ohta, Satoru Nagase, Yosuke Okui, Takayuki Enomoto, Wataru Yamagami, Mikio Mikami, Hideki Tokunaga, Kazuhiko Ino, Kimio Ushijima, Makio Shozu, Hironori Tashiro, Masaki Mandai, Shingo Miyamoto, Ken-Ichirou Morishige, Yoshio Yoshida, Kiyoshi Yoshino, Toshiaki Saito, Eiji Kobayashi, Hiroaki Kobayashi, Munetaka Takekuma, Yoshito Terai, Takuma Fujii, Hiroyuki Kanao, Daisuke Aoki, Hidetaka Katabuchi, Nobuo Yaegashi

    International journal of clinical oncology   26 ( 12 )   2318 - 2330   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The purpose of our study was to conduct a detailed survey of radical hysterectomy in Japanese patients with early-stage cervical cancer, and to compare oncologic outcomes between open and minimally invasive radical hysterectomy. METHODS: In Japan during 2015, the medical records of 929 patients with FIGO stage IB1 and IIA disease treated with radical hysterectomy were retrospectively reviewed. We assessed patients' characteristics, disease-free survival (DFS), overall survival (OS) and prognostic factors for survival. RESULTS: The median patient age was 44 (20-80) years. Most patients (94.4%) had stage IB1 disease. Of the patients who underwent radical hysterectomy, 91.2% underwent open surgery and 8.8% underwent minimally invasive surgery (MIS). The median follow-up period was 40.8 months (range, 0.49-51.1 months). The rate of DFS and OS at 4 years in all patients was 88.3% and 96.4%, respectively. Multivariate analysis identified age (≥ 47), adenocarcinoma histology, tumor size (≥ 2 cm), parametrial invasion, positive lymph node metastasis and institutional accreditation as independent predictors of recurrence, and adenocarcinoma, other cell types, and positive lymph node metastasis as independent predictors of death. Oncologic outcomes in all patients were similar between open and MIS, including DFS and OS. CONCLUSION: The survival rate of the Japanese patients underwent radical hysterectomy for early-stage cervical cancer was favorable. No significant differences were observed for DFS and OS between open and MIS performed by a limited number of surgeons at a limited number of facilities in Japan. Further investigations are required to identify the appropriate patients might benefit from MIS.

    DOI: 10.1007/s10147-021-02017-4

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  • Proposing a molecular classification associated with hypercoagulation in ovarian clear cell carcinoma. 国際誌

    Ryo Tamura, Kosuke Yoshihara, Koji Matsuo, Nozomi Yachida, Ai Miyoshi, Kotaro Takahashi, Kentaro Sugino, Manako Yamaguchi, Yutaro Mori, Kazuaki Suda, Tatsuya Ishiguro, Shujiro Okuda, Teiichi Motoyama, Hirofumi Nakaoka, Akira Kikuchi, Yutaka Ueda, Ituro Inoue, Takayuki Enomoto

    Gynecologic oncology   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Although ovarian clear cell carcinoma (CCC) is associated with high incidence of thromboembolism, the clinicopathological and biological significance of hypercoagulable status in CCC remains unclear. MATERIALS AND METHODS: We retrospectively analyzed pretreatment D-dimer levels, thromboembolic status, and clinical outcome of 125 CCCs in the discovery set and 143 CCCs in two other independent validation sets. Next, we performed RNA sequencing of 93 CCCs and compared coagulation-related gene profiles with 2492 pan-cancer data. We investigated differences in molecular characteristics of CCC subclasses based on coagulation status. RESULTS: In the discovery dataset, D-dimer elevation above the normal range was significantly associated with shorter progression-free and overall survival, irrespective to thromboembolic status. Multivariate analysis identified D-dimer elevation and clinical stage as an independent prognostic factors. We confirmed the prognostic significance of D-dimer elevation in the validation sets. Tissue factor and IL6, which are considered key elements of cancer-induced hypercoagulation, were highly expressed in CCC than in other cancers regardless of D-dimer level. Higher activity of various oncogenic pathways was observed in CCC with compared to without D-dimer elevation. Moreover, hierarchical cluster analysis divided 57 CCCs with D-dimer elevation into immunologically hot and cold tumor subtypes. Hot tumors were characterized by enrichment of T-cell inflamed phenotype, inflammation, the epithelial-mesenchymal transition, and high serum levels of CRP, and cold tumors by enrichment of cell cycle and MYC pathways. CONCLUSIONS: CCC represents hypercoagulable disease and elevate D-dimer is a prognostic factor for decreased survival in CCC. D-dimer high CCC has distinct molecular characteristics into the inflammatory-driven pathway (hot tumor) and the immune-suppressive pathway (cold tumor). Treatment implication of our proposed molecular classification merits further investigation.

    DOI: 10.1016/j.ygyno.2021.08.009

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  • Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistance. 査読 国際誌

    Kaoru Yamawaki, Yutaro Mori, Hiroaki Sakai, Yusuke Kanda, Daisuke Shiokawa, Haruka Ueda, Tatsuya Ishiguro, Kosuke Yoshihara, Kazunori Nagasaka, Takashi Onda, Tomoyasu Kato, Tadashi Kondo, Takayuki Enomoto, Koji Okamoto

    Cancer letters   521   29 - 38   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Patient-derived cells and xenografts retain the biological characteristics of clinical cancers and are instrumental in gaining a better understanding of the chemoresistance of cancer cells. Here, we have established a panel of patient-derived spheroids from clinical materials of ovarian cancer. Systematic evaluation using therapeutic agents indicated that sensitivity to platinum-based compounds significantly varied among the spheroids. To understand the molecular basis of drug sensitivity, we performed integrative analyses combining chemoresistance data and gene expression profiling of the ovarian cancer patient-derived spheroids. Correlation analyses revealed that cisplatin resistance was significantly associated with elevated levels of glucose-6-phosphate dehydrogenase (G6PD) and glutathione-producing redox enzymes. Accordingly, cisplatin-resistant spheroids established in vitro showed elevated levels of G6PD and active glutathione. Moreover, treatment with a G6PD inhibitor in combination with cisplatin suppressed spheroid proliferation in vitro and largely eradicated peritoneal metastasis in mouse xenograft models. Furthermore, G6PD expression was elevated during carcinogenesis and associated with poor prognosis. Thus, the combination of gene expression data and chemosensitivity revealed the essential roles of G6PD-driven redox metabolism in cisplatin resistance, underscoring the significance of an integrative approach using patient-derived cells.

    DOI: 10.1016/j.canlet.2021.08.018

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  • Editor's Note: Targeting Src in Mucinous Ovarian Carcinoma. 国際誌

    Koji Matsuo, Masato Nishimura, Justin N Bottsford-Miller, Jie Huang, Kakajan Komurov, Guillermo N Armaiz-Pena, Mian M K Shahzad, Rebecca L Stone, Ju Won Roh, Angela M Sanguino, Chunhua Lu, Dwight D Im, Neil B Rosenshien, Atsuko Sakakibara, Tadayoshi Nagano, Masato Yamasaki, Takayuki Enomoto, Tadashi Kimura, Prahlad T Ram, Kathleen M Schmeler, Gary E Gallick, Kwong K Wong, Michael Frumovitz, Anil K Sood

    Clinical cancer research : an official journal of the American Association for Cancer Research   27 ( 15 )   4450 - 4450   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1158/1078-0432.CCR-21-2116

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  • Precision medicine for hereditary tumors in gynecologic malignancies. 査読 国際誌

    Masayuki Sekine, Takayuki Enomoto

    The journal of obstetrics and gynaecology research   47 ( 8 )   2597 - 2606   2021年8月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Genomic medicine for gynecologic tumors is characterized by hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS). Poly ADP-ribose polymerase (PARP) inhibitor, olaparib, and the immune checkpoint inhibitor, pembrolizumab, which are drugs that show sensitivity to each hereditary tumor, have begun to spread in clinical practice for gynecologic malignancies. In clinical use, platinum sensitivity is used as a clinical surrogate marker for olaparib sensitivity, and microsatellite instability is used as a biological surrogate marker for pembrolizumab sensitivity. BRCA genetic testing and microsatellite instability test have been used as companion diagnostics before starting olaparib and pembrolizumab treatment, respectively. Homologous recombination deficiency test could be used for companion diagnostic of olaparib combination with bevacizumab in first-line maintenance treatment and niraparib without re-administration of platinum agents in the treatment of recurrence. The approval of the three drugs has been changing the treatment of gynecologic malignancies. Furthermore, preventive medical care has been covered by insurance since April 2020 for breast and/or ovarian cancer patients with germline BRCA1/2 mutation in Japan. This review article outlines the current status and future prospects of precision medicine for gynecologic hereditary tumors focusing on HBOC and LS.

    DOI: 10.1111/jog.14861

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  • Ten-year questionnaire study on human papillomavirus vaccination targeting new female medical school students: Follow-up to the 2015 report. 査読 国際誌

    Akiko Sukegawa, Kenji Ohshige, Yukio Suzuki, Taichi Mizushima, Yutaka Ueda, Masayuki Sekine, Takayuki Enomoto, Etsuko Miyagi

    The journal of obstetrics and gynaecology research   47 ( 10 )   3618 - 3627   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: We aimed to conduct a fixed-point observation questionnaire survey of changes in young women's human papillomavirus (HPV) vaccination status over the course of 10 years. We also investigated the influence of suspension of governmental recommendation for HPV vaccination since June 2013. METHODS: During 2011-2020, we conducted a self-completed questionnaire survey among newly enrolled female medical school students in Yokohama, Japan. The questionnaire featured items regarding HPV vaccination status, age, previous sex education, and knowledge about cervical cancer and HPV vaccination. RESULTS: HPV vaccine uptake rates in 2011 (5.4%) and 2012 (13.5%), when vaccination was self-funded, increased after 2013 (48.7%), when vaccination fees were subsidized. The rate dropped drastically in 2019 (14.3%) and 2020 (5.1%), after suspension of recommendation by the government. Comparisons between new students in 2015/2016, who had high vaccination rates (65.2%), and new students in 2019/2020, who had low vaccination rates (9.8%), showed decreased levels of HPV vaccination awareness, with fewer students having covered cervical cancer prevention in sex education and with respondents having less knowledge about the details of HPV vaccination. CONCLUSIONS: After the suspension of proactive HPV vaccine recommendation, markedly fewer students have been vaccinated against HPV, even those at the vaccination target age. This situation has substantially influenced the lower awareness about cervical cancer prevention, even among medical school students. To protect young women from cervical cancer in Japan, it is crucial for the government to resume proactive recommendation of HPV vaccines as soon as possible.

    DOI: 10.1111/jog.14949

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  • Perceived parenting before adolescence and parity have direct and indirect effects via depression and anxiety on maternal-infant bonding in the perinatal period. 査読 国際誌

    Naoki Fukui, Takaharu Motegi, Yuichiro Watanabe, Koyo Hashijiri, Ryusuke Tsuboya, Maki Ogawa, Takuro Sugai, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

    Psychiatry and clinical neurosciences   75 ( 10 )   312 - 317   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: This study aimed to detect how the perceived parenting practices before adolescence affect maternal-infant bonding in the perinatal period, considering factors such as depression, anxiety and parity. METHODS: We used the Parental Bonding Instrument (PBI) to examine the perceived parenting practices. Participants included 1301 pregnant women who completed the Hospital Anxiety and Depression Scale (HADS) and Mother-to-Infant Bonding Scale (MIBS) at three time points: early pregnancy (approximately 12-15 weeks), late pregnancy (approximately 30-34 weeks) and postpartum (4 weeks after childbirth). We performed a path analysis with factors including parity, PBI subscales (paternal care, paternal overprotection, maternal care and maternal overprotection), HADS and MIBS. RESULTS: Perceived paternal or maternal low care parenting predicted higher HADS and MIBS scores in early pregnancy. Moreover, perceived maternal low care parenting predicted higher HADS scores at postpartum and higher MIBS scores in late pregnancy. Perceived paternal or maternal overprotective parenting predicted higher HADS scores in the pregnancy period. Furthermore, perceived maternal overprotective parenting predicted higher MIBS scores in late pregnancy. Being primipara predicted higher HADS scores at postpartum and higher MIBS scores in early pregnancy and at postpartum. Being multipara predicted higher MIBS scores in late pregnancy. CONCLUSION: This study suggests that perceived negative parenting before adolescence has indirect effects (via anxiety and depression) and direct effects on maternal-infant bonding in the perinatal period. This article is protected by copyright. All rights reserved.

    DOI: 10.1111/pcn.13289

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  • The efficacy and safety profile of 2-weekly dosing of bevacizumab-containing chemotherapy for platinum-resistant recurrent ovarian cancer. 査読

    Masayuki Sekine, Takayuki Enomoto, Yoh Watanabe, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki

    International journal of clinical oncology   26 ( 11 )   2123 - 2129   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Despite being widely used, to date (June 2021), the regimen of bevacizumab 10 mg/kg every 2 weeks (Q2W) combined with chemotherapy is not approved in Japan for patients with platinum-resistant recurrent ovarian cancer. In this retrospective analysis, we evaluated the usage patterns of bevacizumab administered for platinum-resistant recurrent ovarian cancer. METHODS: We obtained clinical data from 155 Japanese medical facilities between November 2013 and December 2018 via a survey. Items included the number of cases of platinum-resistant recurrent ovarian cancer treated with bevacizumab according to dosage. For regimens including bevacizumab 10 mg/kg Q2W, additional information was requested relating to concomitantly administered agents, and the efficacy and safety of the regimen. RESULTS: Of 1739 bevacizumab-containing regimens reported in 1633 patients with recurrent ovarian cancer, 264 used 10 mg/kg Q2W. The overall response rate (ORR) with this regimen was 26.1%. Response rates varied according to regimen and were particularly favorable when bevacizumab 10 mg/kg Q2W was administered with paclitaxel (ORR, 53.0%) versus liposomal doxorubicin (15.0%; P < 0.0001) and irinotecan (7.7%; P < 0.028). The most frequent Grade ≥ 3 adverse events associated with bevacizumab 10 mg/kg Q2W were neutropenia (11.7%) and hypertension (11.7%). The most frequent bevacizumab-associated Grade ≥ 3 adverse events with bevacizumab plus paclitaxel versus bevacizumab plus liposomal doxorubicin were hypertension (9.0% versus 13.9%) and proteinuria (3.0% versus 8.4%). CONCLUSIONS: Bevacizumab 10 mg/kg Q2W appears efficacious for patients with recurrent ovarian cancer, with a manageable toxicity profile. Approval of this regimen is clinically desirable for Japanese patients with ovarian cancer.

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  • The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium. 国際誌

    Manako Yamaguchi, Kosuke Yoshihara, Nozomi Yachida, Kazuaki Suda, Ryo Tamura, Tatsuya Ishiguro, Takayuki Enomoto

    Journal of personalized medicine   11 ( 8 )   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The histology of the endometrium has traditionally been established by observation of two-dimensional (2D) pathological sections. However, because human endometrial glands exhibit coiling and branching morphology, it is extremely difficult to obtain an entire image of the glands by 2D observation. In recent years, the development of three-dimensional (3D) reconstruction of serial pathological sections by computer and whole-mount imaging technology using tissue clearing methods with high-resolution fluorescence microscopy has enabled us to observe the 3D histoarchitecture of tissues. As a result, 3D imaging has revealed that human endometrial glands form a plexus network in the basalis, similar to the rhizome of grass, whereas mouse uterine glands are single branched tubular glands. This review summarizes the relevant literature on the 3D structure of mouse and human endometrium and discusses the significance of the rhizome structure in the human endometrium and the expected role of understanding the 3D tissue structure in future applications to systems biology.

    DOI: 10.3390/jpm11080713

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  • A nationwide birth year-by-year analysis of effectiveness of HPV vaccine in Japan. 査読 国際誌

    Asami Yagi, Yutaka Ueda, Satoshi Nakagawa, Tatsuo Masuda, Takashi Miyatake, Sayaka Ikeda, Hazuki Abe, Kei Hirai, Masayuki Sekine, Etsuko Miyagi, Takayuki Enomoto, Tomio Nakayama, Tadashi Kimura

    Cancer science   112 ( 9 )   3691 - 3698   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In Japan, the age-adjusted incidence of cervical cancer has been increasing constantly and rapidly among younger women. We set out to accurately confirm the effectiveness of the HPV vaccine in Japan. Data were collected for women born in the fiscal year (FY) 1990 to 1997, who became eligible for their 20-y-old cervical cancer screening between the FY 2010 to 2017. The adjusted incidence of cervical intraepithelial neoplasia (CIN)1+ in women born in FY 1990 to 1993, that is those who reached the national vaccination target age prior to the introduction of publicly subsidized HPV vaccinations, referred here after as "the pre-introduction generation", was 1.42% (242/17 040). The incidence in the "vaccination generation" (women born in FY 1994 to 1997, that is those who were heavily vaccinated as a group when they were of the nationally targeted age of 13-16) was 1.66% (135/8020). There was no significant difference between these incidence rates. However, our FY birth year-by-year analysis revealed that the incidence of CIN1+ was obviously lower than that predicted based on just the trend for CIN1+ seen in the pre-introduction generation. Our analysis revealed that the incidence of CIN3+ was obviously lower in the vaccination generation than in the pre-introduction generation (P = .0008). The incidence of CIN was already tending to increase in both the pre-introduction and vaccination generations. The changes in CIN incidence by individual birth FY must be examined to accurately determine the actual effects of the HPV vaccine for reducing mild cervical lesions.

    DOI: 10.1111/cas.15060

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  • Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study. 査読 国際誌

    Shin Nishio, Koji Matsuo, Shinya Matsuzaki, Tomoyasu Kato, Shoji Kamiura, Hiroshi Adachi, Masao Okadome, Toshiaki Nakamura, Mikio Mikami, Takayuki Enomoto

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Studies on vulvar adenocarcinoma are lacking. Thus, we aimed to compare the characteristics and survival outcomes between vulvar adenocarcinoma and squamous cell carcinoma (SCC). METHODS: This was a preplanned sub-analysis of a previously organized nationwide retrospective observational study in Japan conducted between 2001 and 2010 (JGOG-1075S). Surgically treated women with stage I-IV vulvar invasive adenocarcinoma were compared to those with SCC. Multivariable analysis was performed to identify patient and tumor characteristics related to adenocarcinoma. Inverse probability of treatment weighting was used to balance the background differences, and a Cox proportional hazards regression model was fitted to estimate the effect of the histological type on survival. RESULTS: Forty-eight women with adenocarcinoma were compared with 537 women with SCC. On multivariable analysis, women with adenocarcinoma were younger (median age, 64.5 vs. 70 years, adjusted odds ratio [OR] per age 0.975, 95% confidence interval [CI] 0.955-0.995, P = 0.016) and had higher positive surgical margin rates (31.2% vs. 18.4%, adjusted OR 2.376, 95% CI 1.188-4.754, P = 0.014) than those with SCC. However, according to the weighted model, the survival outcomes were comparable (hazard ratio for progression-free survival, 1.088, 95% CI 0.740-1.601, P = 0.667 and hazard ratio for overall survival, 1.008, 95% CI 0.646-1.573, P = 0.973). Similar associations were observed when the cohort was stratified by age (≤70 or >70 years), stage (I-II or III-IV), and surgical margin (negative or positive) (all, P > 0.05). CONCLUSION: Vulvar adenocarcinoma is characterized by a younger age at diagnosis and higher positive surgical margin rates than SCC, but the survival outcomes are comparable.

    DOI: 10.1016/j.ejso.2021.07.002

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  • Differences in Ovarian and Other Cancers Risks by Population and BRCA Mutation Location. 国際誌

    Masayuki Sekine, Koji Nishino, Takayuki Enomoto

    Genes   12 ( 7 )   2021年7月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Hereditary breast and ovarian cancer is caused by a germline mutation in BRCA1 or BRCA2 genes. The frequency of germline BRCA1/2 gene mutation carriers and the ratio of germline BRCA1 to BRCA2 mutations in BRCA-related cancer patients vary depending on the population. Genotype and phenotype correlations have been reported in BRCA mutant families, however, the correlations are rarely used for individual risk assessment and management. BRCA genetic testing has become a companion diagnostic for PARP inhibitors, and the number of families with germline BRCA mutation identified is growing rapidly. Therefore, it is expected that analysis of the risk of developing cancer will be possible in a large number of BRCA mutant carriers, and there is a possibility that personal and precision medicine for the carriers with specific common founder mutations will be realized. In this review, we investigated the association of ovarian cancer risk and BRCA mutation location, and differences of other BRCA-related cancer risks by BRCA1/2 mutation, and furthermore, we discussed the difference in the prevalence of germline BRCA mutation in ovarian cancer patients. As a result, although there are various discussions, there appear to be differences in ovarian cancer risk by population and BRCA mutation location. If it becomes possible to estimate the risk of developing BRCA-related cancer for each BRCA mutation type, the age at risk-reducing salpingo-oophorectomy can be determined individually. The decision would bring great benefits to young women with germline BRCA mutations.

    DOI: 10.3390/genes12071050

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  • Uterine serous carcinoma. 査読 国際誌

    Giorgio Bogani, Isabelle Ray-Coquard, Nicole Concin, Natalie Y L Ngoi, Philippe Morice, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Remi A Nout, Domenica Lorusso, Michelle M Vaughan, Marta Bini, Masashi Takano, Diane Provencher, Alice Indini, Satoru Sagae, Pauline Wimberger, Robert Póka, Yakir Segev, Se Ik Kim, Francisco J Candido Dos Reis, Salvatore Lopez, Andrea Mariani, Mario M Leitao Jr, Francesco Raspagliesi, Pieluigi Benedetti Panici, Violante Di Donato, Ludovico Muzii, Nicoletta Colombo, Giovanni Scambia, Sandro Pignata, Bradley J Monk

    Gynecologic oncology   162 ( 1 )   226 - 234   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Serous endometrial cancer represents a relative rare entity accounting for about 10% of all diagnosed endometrial cancer, but it is responsible for 40% of endometrial cancer-related deaths. Patients with serous endometrial cancer are often diagnosed at earlier disease stage, but remain at higher risk of recurrence and poorer prognosis when compared stage-for-stage with endometrioid subtype endometrial cancer. Serous endometrial cancers are characterized by marked nuclear atypia and abnormal p53 staining in immunohistochemistry. The mainstay of treatment for newly diagnosed serous endometrial cancer includes a multi-modal therapy with surgery, chemotherapy and/or radiotherapy. Unfortunately, despite these efforts, survival outcomes still remain poor. Recently, The Cancer Genome Atlas (TCGA) Research Network classified all endometrial cancer types into four categories, of which, serous endometrial cancer mostly is found within the "copy number high" group. This group is characterized by the increased cell cycle deregulation (e.g., CCNE1, MYC, PPP2R1A, PIKCA, ERBB2 and CDKN2A) and TP53 mutations (90%). To date, the combination of pembrolizumab and lenvatinib is an effective treatment modality in second-line therapy, with a response rate of 50% in advanced/recurrent serous endometrial cancer. Owing to the unfavorable outcomes of serous endometrial cancer, clinical trials are a priority. At present, ongoing studies are testing novel combinations of various targeted and immunotherapeutic agents in newly diagnosed and advanced/recurrent endometrial cancer - an important strategy for serous endometrial cancer, whereby tumors are usually p53+ and pMMR, making response to PD-1 inhibitor monotherapy unlikely. Here, the rare tumor working group (including members from the European Society of Gynecologic Oncology (ESGO), Gynecologic Cancer Intergroup (GCIG), and Japanese Gynecologic Oncology Group (JGOG)), performed a narrative review reporting on the current landscape of serous endometrial cancer and focusing on standard and emerging therapeutic options for patients affected by this difficult disease.

    DOI: 10.1016/j.ygyno.2021.04.029

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  • 【婦人科がん機能温存治療のすべて】子宮頸がん 広汎子宮頸部摘出術

    吉原 弘祐, 榎本 隆之

    産科と婦人科   88 ( 7 )   824 - 828   2021年7月

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    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    早期子宮頸癌に対する妊孕性温存手術として、広汎子宮頸部摘出術が広く行われるようになっている。広汎子宮頸部摘出術の治療成績や術後の妊娠率、妊娠に至った場合の周産期成績が後方視的観察研究として複数報告されており、その手術適応基準が『子宮頸癌治療ガイドライン2017年版』に記載されるまでになった。本稿では、日本における広汎子宮頸部摘出術の現状について整理し、当科での経験を紹介する。(著者抄録)

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  • 外科系医師はどのようにして医学教育のキャリアを形成していくのか? 臨床医から、臨床医の教育、そして医学教育学へ 医学教育学を学ぶ産婦人科医として

    磯部 真倫, 榎本 隆之, 錦織 宏

    医学教育   52 ( Suppl. )   37 - 37   2021年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • 新時代の遠隔ハンズオンセミナー Facebook、LINE、Zoomを用いた遠隔腹腔鏡手術トレーニングの経験

    磯部 真倫, 堀澤 信, 榎本 隆之

    医学教育   52 ( Suppl. )   21 - 21   2021年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • 卵黄嚢腫瘍に酷似する組織所見を呈した卵巣明細胞癌の一例

    島 英里, 西野 幸治, 黒澤 めぐみ, 田村 亮, 磯部 真倫, 安達 聡介, 安田 麻友, 齋藤 宏美, 工藤 梨沙, 鈴木 美保, 石黒 竜也, 吉原 弘祐, 小林 暁子, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   223 - 223   2021年7月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 子宮体癌における卵巣転移症例の臨床病理学的特徴の検討

    谷地田 希, 吉原 弘祐, 安田 麻友, 黒澤 めぐみ, 齋藤 宏美, 鈴木 美保, 工藤 梨沙, 島 英里, 田村 亮, 石黒 竜也, 安達 聡介, 磯部 真倫, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   312 - 312   2021年7月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • HPVワクチンの積極的勧奨中止の影響によるHPV16/18型感染率の再上昇

    工藤 梨沙, 関根 正幸, 山口 真奈子, 黒澤 めぐみ, 安達 聡介, 榎本 隆之

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   327 - 327   2021年7月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 婦人科がん治療医の遺伝性乳癌卵巣癌症候群(HBOC)診療に関する実態調査から見えてきたこと

    小林 佑介, 高橋 孝幸, 増田 健太, 平沢 晃, 竹原 和宏, 津田 均, 渡部 洋, 織田 克利, 永瀬 智, 万代 昌紀, 岡本 愛光, 八重樫 伸生, 三上 幹男, 榎本 隆之, 青木 大輔

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   219 - 219   2021年7月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • HPVワクチン有効性評価(全国自治体症例対照研究)

    池田 さやか, 上田 豊, 原 めぐみ, 八木 麻未, 北村 哲久, 喜多村 祐里, 小西 宏, 垣添 忠生, 関根 正幸, 榎本 隆之, 祖父江 友孝

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   217 - 217   2021年7月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 【ポストコロナ時代の産婦人科医療】学会開催と学会の役割 第73回日本産科婦人科学会学術講演会を主催して

    榎本 隆之, 関根 正幸

    産婦人科の実際   70 ( 7 )   745 - 750   2021年7月

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    記述言語:日本語   出版者・発行元:金原出版(株)  

    <文献概要>新型コロナウイルス感染症が蔓延しているなか,第73回日本産科婦人科学会学術講演会を,日本産科婦人科学会としては初めての現地開催とWeb開催併用のハイブリッド形式にて開催した。昨年以来,Web学会の利便性を享受してきたが,現地開催のよい点も浮き彫りになった。ポストコロナ時代の学術講演会はハイブリッド開催が主流になると思われるが,何をWebに移行し,何を従来の現地開催に残すかの議論が必要である。

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  • HPVワクチン有効性評価(全国自治体症例対照研究)

    池田 さやか, 上田 豊, 原 めぐみ, 八木 麻未, 北村 哲久, 喜多村 祐里, 小西 宏, 垣添 忠生, 関根 正幸, 榎本 隆之, 祖父江 友孝

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   217 - 217   2021年7月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 【ゲノム時代の生殖内分泌学】ゲノムと子宮内膜症

    吉原 弘祐, 榎本 隆之

    HORMONE FRONTIER IN GYNECOLOGY   28 ( 2 )   111 - 114   2021年6月

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    記述言語:日本語   出版者・発行元:(株)メディカルレビュー社  

    <文献概要>子宮内膜症上皮は,摘出された卵巣内膜症性嚢腫の限られた領域にしか存在しないことが多く,これまで子宮内膜症に対するゲノム解析は困難であった。近年,シークエンス技術革新とレーザーマイクロダイセクションによる子宮内膜症上皮の適切なサンプリングにより,子宮内膜症のゲノム異常が同定された。特に良性腫瘍である子宮内膜症に,癌関連遺伝子変異が高頻度に存在することが明らかになっており,今後,子宮内膜症のゲノム異常に注目した病態解明が進むだろう。

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J02833&link_issn=&doc_id=20210608160006&doc_link_id=10.34449%2FJ0015.28.02_0027-0030&url=https%3A%2F%2Fdoi.org%2F10.34449%2FJ0015.28.02_0027-0030&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • BRCA Genetic Test and Risk-Reducing Salpingo-Oophorectomy for Hereditary Breast and Ovarian Cancer: State-of-the-Art. 国際誌

    Masayuki Sekine, Koji Nishino, Takayuki Enomoto

    Cancers   13 ( 11 )   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In the field of gynecology, the approval of the PARP inhibitors (PARPi) has been changing the treatment of ovarian cancer patients. The BRCA genetic test and the HRD test are being used as a companion diagnosis before starting PARPi treatment. BRACAnalysis CDx® and Myriad myChoice® HRD test are widely used as a BRCA genetic test and HRD test, respectively. In addition, FoundationOne®CDx is sometimes used as a tumor BRCA test and HRD test. In clinical practice, gynecologists treating ovarian cancer are faced with making decisions such as whether to recommend the gBRCA test to all ovarian cancer patients, whether to perform the gBRCA test first or HRD test first, and so on. Regarding the judgment result of the HRD test, the cutoff value differs depending on the clinical trial, and the prevalence of gBRCA pathogenic variant rate is different in each histological type and country. A prospective cohort study showed that RRSO reduced all-cause mortality in both pre- and postmenopausal women; however, RRSO significantly reduced the risk of breast cancer for BRCA2 pathogenic variant carriers, but not for BRCA1 pathogenic variant carriers. Moreover, salpingectomy alone is said to not decrease the risk of developing ovarian or breast cancer, so further discussion is evidently required. We discuss the current situation and problems in doing BRCA genetic test and RRSO in this review article.

    DOI: 10.3390/cancers13112562

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  • Attitudes toward overtime work and self-training: A survey on obstetricians and gynecologists in Japan. 国際誌

    Michinori Mayama, Masayuki Sekine, Yohei Onodera, Tokumasa Suemitsu, Yuto Maeda, Kazutoshi Nakano, Yosuke Sugita, Jumpei Ogura, Takuma Ohsuga, Chisato Kodera, Takashi Murakami, Michiko Kido, Yukio Suzuki, Ayako Shibata, Koji Nishijima, Takeshi Umazume, Satoshi Nakagawa, Nobuya Unno, Hiroaki Komatsu, Makio Shozu, Takayuki Enomoto, Hidemichi Watari

    The journal of obstetrics and gynaecology research   47 ( 5 )   1666 - 1674   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: The Ministry of Health, Labour, and Welfare of Japan proposed a regulation of overtime work as a reform in work style. However, the regulation may deteriorate the quality of medical services due to the reduction in training time. Thus, the study aimed to reveal perceptions in terms of generation gaps in views on self-training and overtime work, among members of the Japan Society of Obstetrics and Gynecology (JSOG). METHODS: A web-based, self-administered questionnaire survey was conducted among members of the JSOG. In total, 1256 respondents were included in the analysis. Data were collected on age, sex, experience as a medical doctor, location of workplace, work style, the type of main workplace, and number of full-time doctors in the main workplace. The study examined the attitudes of the respondents toward overtime work and self-training. The respondents were categorized based on experience as a medical doctor. RESULTS: According to years of experience, 112 (8.9%), 226 (18.0%), 383 (30.5%), 535 (42.6%) doctors have been working for ≤5, 6-10, 11-19, and ≥ 20 years, respectively. Although 54.5% of doctors with ≤5 years of experience expected the regulation on working hours to improve the quality of medical services, those with ≥20 years of experience expressed potential deterioration. After adjusting for covariates, more years of experience were significantly related with the expectation of deterioration in the quality of medical services. CONCLUSIONS: The study revealed a generation gap in the views about self-training and overtime work among obstetricians and gynecologists in Japan.

    DOI: 10.1111/jog.14735

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  • A successfully treated case of an acute presentation of congenital thrombotic thrombocytopenic purpura (Upshaw–Schulman syndrome) with decreased ADAMTS13 during late stage of pregnancy

    Taro Nonaka, Masayuki Yamaguchi, Koji Nishijima, Masato Moriyama, Koichi Takakuwa, Takayuki Enomoto

    Journal of Obstetrics and Gynaecology Research   47 ( 5 )   1892 - 1897   2021年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/jog.14737

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jog.14737

  • Wait-time for adjuvant radiotherapy and oncologic outcome in early-stage cervical cancer: A treatment implication during the coronavirus pandemic. 国際誌

    Koji Matsuo, Muneaki Shimada, Shinya Matsuzaki, Takayuki Enomoto, Mikio Mikami

    European journal of cancer (Oxford, England : 1990)   148   117 - 120   2021年5月

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  • Biological significance of KRAS mutant allele expression in ovarian endometriosis. 国際誌

    Nozomi Yachida, Kosuke Yoshihara, Kazuaki Suda, Hirofumi Nakaoka, Haruka Ueda, Kentaro Sugino, Manako Yamaguchi, Yutaro Mori, Kaoru Yamawaki, Ryo Tamura, Tatsuya Ishiguro, Hiroaki Kase, Teiichi Motoyama, Takayuki Enomoto

    Cancer science   112 ( 5 )   2020 - 2032   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    KRAS is the most frequently mutated in ovarian endometriosis. However, it is unclear whether the KRAS mutant allele's mRNA is expressed and plays a biological role in ovarian endometriosis. Here, we performed mutation-specific RNA in situ hybridization to evaluate mutant allele expression of KRAS p.G12V, the most frequently detected mutation in ovarian endometriosis in our previous study, in formalin-fixed paraffin-embedded tissue (FFPE) samples of ovarian endometriosis, cancer cell lines, and ovarian cancers. First, we verified that mutant or wild-type allele of KRAS were expressed in all 5 cancer cell lines and 9 ovarian cancer cases corresponding to the mutation status. Next, we applied this assay to 26 ovarian endometriosis cases, and observed mutant allele expression of KRAS p.G12V in 10 cases. Mutant or wild-type allele of KRAS were expressed in line with mutation status in 12 available endometriosis cases for which KRAS gene sequence was determined. Comparison of clinical features between ovarian endometriosis with KRAS p.G12V mutant allele expression and with KRAS wild-type showed that KRAS p.G12V mutant allele expression was significantly associated with inflammation in ovarian endometriosis. Finally, we assessed the spatial distribution of KRAS mutant allele expression in 5 endometriosis cases by performing multiregional sampling. Intratumor heterogeneity of KRAS mutant allele expression was observed in two endometriosis cases, whereas the spatial distribution of KRAS p.G12V mutation signals were diffuse and homogenous in ovarian cancer. In conclusion, evaluation of oncogene mutant expression will be useful for clarifying the biological significance of oncogene mutations in benign tumors.

    DOI: 10.1111/cas.14871

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  • 【卵巣癌におけるHRDとPARP阻害薬の効果】卵巣癌の臨床像とHRD

    吉原 弘祐, 榎本 隆之

    産婦人科の実際   70 ( 5 )   495 - 499   2021年5月

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    記述言語:日本語   出版者・発行元:金原出版(株)  

    <文献概要>卵巣癌の分子生物学的特徴は,組織型で大きく異なる。例えば,高異型度漿液性癌ではTP53体細胞病的バリアントを90%以上で認めるのに対し,内膜症関連卵巣癌として知られる明細胞癌や類内膜癌ではARID1AやPIK3CA体細胞病的バリアントを高率に認める。同様に,卵巣癌治療のコンパニオン診断として利用可能になった相同組換え修復欠損(HRD)についても組織型ごとにその頻度が異なる可能性がある。本稿では,組織型に焦点を当てBRCA1/2を含めた相同組換え修復関連遺伝子の病的バリアントの頻度を概説する。

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  • Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2017 and annual treatment report for 2012 査読 国際誌

    Nagase S, Ohta T, Takahashi F, Yaegashi N, Enomoto T, Katabuchi H, Kawana K, Kobayashi H, Kobayashi Y, Shozu M, Baba T, Morishige K, Yoshida Y, Yoshino K, Yamagami W, Tokunaga H

    Journal of Obstetrics and Gynaecology Research   47 ( 5 )   1631 - 1642   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Obstetrics and Gynaecology Research  

    Aim: To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2017 and the Annual Treatment Report for 2012, on the outcomes of patients who started treatment in 2012. Methods: The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2017 were analyzed retrospectively. Survival of the patients who started treatment with cervical, endometrial and ovarian cancer in 2012 was analyzed by using the Kaplan-Meier, log-rank and Wilcoxon tests. Results: Treatment was initiated in 2017 for 7710 patients with cervical cancer; 11 120 with endometrial cancer; 7029 with ovarian, tubal and peritoneal cancer; 2164 with ovarian borderline tumors; and with the others (213 vulvar cancer, 139 vaginal cancer, 366 uterine sarcoma, 41 uterine adenosarcoma and 131 trophoblastic diseases). This clinicopathological information was summarized as the patient annual report. The 5-year survival rates of the patients with cervical cancer were 92.9, 75.5, 58.2 and 26.7% for stages I, II, III and IV, respectively. The 5-year survival rates for the patients with endometrial cancer were 93.6, 85.6, 72.6 and 27.3% for stages I, II, III and IV, respectively. The 5-year survival rates for the patients with ovarian cancer (surface epithelial-stromal tumors) were 92.5, 83.5, 49.5 and 30.8% for stages I, II, III and IV, respectively. Conclusion: The annual tumor report is an important survey that provides knowledge on gynecological malignancy trends in Japan.

    DOI: 10.1111/jog.14724

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  • A retrospective study for investigating the outcomes of endometrial cancer treated with radiotherapy. 査読 国際誌

    Kensuke Sakai, Wataru Yamagami, Hiroko Machida, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Daisuke Aoki, Mikio Mikami

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To clarify the role of radiotherapy for endometrial cancer. METHODS: Data were analyzed for 39 247 patients with endometrial cancer registered with the Gynecologic Cancer Registry of the Japan Society of Obstetrics and Gynecology from 2004 to 2011. RESULTS: The rates of 5-year overall survival (5y-OS) in the radiotherapy and surgery groups were 53.6% and 94.5% in stage I or II, and 15.5% and 67.5% in stage III or IV, respectively. The prognosis in the radiotherapy group was significantly poorer than that in the surgery group. In multivariate analysis, age, advanced stage, histological type, risk of recurrence, and initial radiotherapy were independent prognostic factors. The rates of 5y-OS with no adjuvant therapy, adjuvant chemotherapy, and adjuvant radiotherapy were 95.3%, 92.9%, and 87.1% for stage I or II, respectively, with significant differences among all groups (P < 0.001), and 60.0%, 70.4%, and 55.5% for stage III or IV, respectively, with significant differences of adjuvant chemotherapy with no adjuvant therapy (P < 0.001) and with adjuvant radiotherapy (P < 0.001). In multivariate analysis, age, advanced stage, histological type, lymphadenectomy, and adjuvant radiotherapy were independent prognostic factors. CONCLUSION: Patients treated with radiotherapy had a significantly poorer prognosis and the appropriate indication of radiotherapy for endometrial cancer requires further study.

    DOI: 10.1002/ijgo.13725

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  • Three-dimensional understanding of the morphological complexity of the human uterine endometrium. 国際誌

    Manako Yamaguchi, Kosuke Yoshihara, Kazuaki Suda, Hirofumi Nakaoka, Nozomi Yachida, Haruka Ueda, Kentaro Sugino, Yutaro Mori, Kaoru Yamawaki, Ryo Tamura, Tatsuya Ishiguro, Teiichi Motoyama, Yu Watanabe, Shujiro Okuda, Kazuki Tainaka, Takayuki Enomoto

    iScience   24 ( 4 )   102258 - 102258   2021年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative "endometrium-related disease," and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases.

    DOI: 10.1016/j.isci.2021.102258

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  • PET/MR imaging for the evaluation of cervical cancer during pregnancy. 国際誌

    Tatsuya Ishiguro, Nobumichi Nishikawa, Shiro Ishii, Kosuke Yoshihara, Kazufumi Haino, Masayuki Yamaguchi, Sosuke Adachi, Takafumi Watanabe, Shu Soeda, Takayuki Enomoto

    BMC pregnancy and childbirth   21 ( 1 )   288 - 288   2021年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Malignancy during pregnancy is increasing, and the most common type of malignancy is uterine cervical cancer. When planning the treatment of cervical cancer, it is important to look for signs of metastasis before surgery, especially metastasis to the lymph nodes. In this report, we assessed the diagnostic value of positron emission tomography/magnetic resonance imaging (PET/MRI) for evaluating cervical cancer propagation before surgery, with a focus on pregnant women. CASE PRESENTATION: 18F Fluorodeoxyglucose (FDG)-PET/MRI was performed in seven pregnant cervical cancer patients (28-34 years old) at 9-18 gestational weeks. In case #5, a second PET/MRI was performed at 24 gestational weeks. Of seven FDG-PET/MRI examination series in six cases (cases #1-6), FDG-PET/MR imaging could detect cervical tumors with abnormal FDG accumulation; these tumors were confirmed with a standardized uptake value max (SUV max) titer of 4.5-16. A second PET/MRI examination in case #5 revealed the same SUV max titer as the first examination. In these six imaging series (cases #1-5), there were no signs of cancer metastasis to the parametrium and lymph nodes. However, in case #6, abnormal FDG accumulation in the left parametrial lymph nodes was also detectable. Pathological examination showed lymph node metastasis in case #6. In case #7, PET/MRI could not detect any abnormal FDG accumulation in the cervix and other sites. Cone biopsy demonstrated only micro-invasive squamous cell carcinoma. After treatment for cervical cancer, all seven patients have had no recurrence of disease within the follow-up period (2.8-5.6 years), and their children have developed appropriately. CONCLUSION: PET/MRI is an effective imaging tool to evaluate cervical cancer progression in pregnancy.

    DOI: 10.1186/s12884-021-03766-w

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  • Clinical Significance of Mesenteric Lymph Node Involvement in the Pattern of Liver Metastasis in Patients with Ovarian Cancer. 査読 国際誌

    Kana Tanaka, Yoshifumi Shimada, Koji Nishino, Kosuke Yoshihara, Masato Nakano, Hitoshi Kameyama, Takayuki Enomoto, Toshifumi Wakai

    Annals of surgical oncology   28 ( 12 )   7606 - 7613   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Mesenteric lymph node (MLN) involvement is often observed in ovarian cancer (OC) with rectosigmoid invasion. This study aimed to investigate the clinical significance of MLN involvement in the pattern of liver metastasis in patients with OC. METHODS: We included 85 stage II-IV OC patients who underwent primary or interval debulking surgery. Twenty-seven patients underwent rectosigmoid resection, whose status of MLN involvement was judged from hematoxylin and eosin (H&E) staining of resected specimens. The prognostic significance of clinicopathological characteristics, including MLN involvement, was evaluated using univariate and multivariate analyses. RESULTS: MLN involvement was detected in 14/85 patients with stage II-IV OC. Residual tumor status, cytology of ascites, and MLN involvement were independent prognostic factors for progression-free survival (PFS; p = 0.033, p = 0.014, and p = 0.008, respectively). When patients were classified into three groups (no MLN, one MLN, two or more MLNs), the number of MLNs involved corresponded to three distinct groups in PFS (p = 0.001). The 3-year cumulative incidence of liver metastasis of patients with MLN involvement was significantly higher than that of patients without MLN involvement (61.1% vs. 8.9%, p < 0.001). MLN involvement was significantly associated with liver metastasis of hematogenous origin (p < 0.001) compared with peritoneal disseminated origin. CONCLUSION: MLN involvement is an important prognostic factor in OC, predicting poor prognosis and liver metastasis of hematogenous origin.

    DOI: 10.1245/s10434-021-09899-8

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  • Health consciousness and cervical cancer screening rates in HPV-unvaccinated girls: comparison from HPV-recommended and HPV-recommendation-suspended program periods. 国際誌

    Ai Miyoshi, Yutaka Ueda, Asami Yagi, Mariko Taniguchi, Masayuki Sekine, Takayuki Enomoto, Tadashi Kimura

    Human vaccines & immunotherapeutics   17 ( 4 )   1068 - 1072   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In Japan, the vast majority of females between 13 and 24 are now unvaccinated for HPV and thus unprotected from HPV-caused cervical cancer. We analyzed the differences among these unvaccinated females regarding their understanding of the HPV vaccine, its role in cervical cancer prevention, and their need for cervical cancer screening - based on whether they refused vaccination when their government's recommendation for HPV vaccination was still in effect (vaccination-recommended group) - or during the last 7 years, while the government suspension was in effect (recommendation-suspended group). The vaccination-recommended group understood more about the HPV vaccine and the best timing for HPV vaccination than the recommendation-suspended group (p < .0001 and p = .002, respectively). We found that girls in the vaccination-recommended group had more chances to talk with the family about cervical cancer and they were more afraid of acquiring the disease (p < .0001 and p < .0001, respectively). The girls in the recommendation-suspended group tended to feel more inhibited from talking about cervical cancer with friends and acquaintances (p = .0262). The cervical cancer screening rate of the vaccination-recommended group was significantly higher (p = .014).

    DOI: 10.1080/21645515.2020.1830684

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  • Exclusive Breastfeeding Is Not Associated with Maternal-Infant Bonding in Early Postpartum, Considering Depression, Anxiety, and Parity. 査読 国際誌

    Naoki Fukui, Takaharu Motegi, Yuichiro Watanabe, Koyo Hashijiri, Ryusuke Tsuboya, Maki Ogawa, Takuro Sugai, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

    Nutrients   13 ( 4 )   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It is important to clarify how the breastfeeding method affects women's mental health, and how women's mental health affects the breastfeeding method in the early postpartum period when major depression and other psychiatric problems are most likely to occur. This study aimed to examine this bidirectional relationship in the early postpartum period. Participants were 2020 postpartum women who completed the Hospital Anxiety and Depression Scale (HADS) and Mother-to-Infant Bonding Scale (MIBS). We obtained data for participants' breastfeeding method for four weeks after childbirth. We performed a path analysis with factors including breastfeeding method (exclusive breastfeeding or non-exclusive breastfeeding), parity (primipara or multipara), the two HADS subscales (anxiety and depression), and the two MIBS subscales (lack of affection and anger and rejection). The path analysis showed that breastfeeding method did not significantly affect depression, anxiety, and maternal-infant bonding in the early postpartum period. Women with higher anxiety tended to use both formula-feeding and breastfeeding. Our study suggests that exclusive breastfeeding is not associated with maternal-fetal bonding in early postpartum, considering depression, anxiety, and parity.

    DOI: 10.3390/nu13041184

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  • A randomized phase III trial of adjuvant chemotherapy versus concurrent chemoradiotherapy for postoperative cervical cancer: Japanese Gynecologic Oncology Group study (JGOG1082). 国際誌

    Akiko Furusawa, Munetaka Takekuma, Keita Mori, Tomoka Usami, Eiji Kondo, Shin Nishio, Koji Nishino, Yuichiro Miyamoto, Ryoichi Yoshimura, Miho Watanabe, Mikio Mikami, Takayuki Enomoto

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society   31 ( 4 )   623 - 626   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The standard treatment for stage IB-IIB cervical cancer is radiotherapy or radical hysterectomy; after radical hysterectomy, adjuvant concurrent chemoradiotherapy is recommended for patients with high risk factors. However, adjuvant concurrent chemoradiotherapy can cause severe gastrointestinal and urinary toxicity. PRIMARY OBJECTIVE: To assess whether postoperative adjuvant chemotherapy is not inferior to adjuvant concurrent chemoradiotherapy for overall survival in patients with high risk cervical cancer. STUDY HYPOTHESIS: Adjuvant chemotherapy is not inferior to adjuvant concurrent chemoradiotherapy for overall survival and will reduce severe toxicities. TRIAL DESIGN: Patients with high risk factors after radical hysterectomy will be randomized 1:1 to receive adjuvant concurrent chemoradiotherapy or adjuvant chemotherapy. Treatment will be started within 6 weeks of surgery. The concurrent chemoradiotherapy group will receive whole pelvis irradiation (50.4 Gy) and cisplatin (40 mg/m2/week). The chemotherapy group will receive paclitaxel (175 mg/m2) plus cisplatin (50 mg/m2) or carboplatin (AUC=6) every 3 weeks for six cycles. MAJOR INCLUSION/EXCLUSION CRITERIA: Patients with high risk stage IB-IIB cervical cancer (squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma) who underwent radical hysterectomy are eligible for the study. High risk is defined as the presence of pelvic lymph node metastasis and/or parametrial invasion. PRIMARY ENDPOINT: The primary endpoint is overall survival. SAMPLE SIZE: 250 patients in total are required. ESTIMATED DATES FOR COMPLETING ACCRUAL: This study began in November 2019, and 250 patients will be accrued within 5 years. TRIAL REGISTRATION NUMBER: The study has been registered with the Japan Registry of Clinical Trials (jRCTs041190042).

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  • HPVワクチンの現状 有効性と安全性

    工藤 梨沙, 関根 正幸, 山口 真奈子, 黒澤 めぐみ, 安達 聡介, 榎本 隆之

    新潟県臨床検査技師会誌   61 ( 2 )   50 - 57   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)新潟県臨床検査技師会  

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  • ASO Author Reflections: Clinical Significance of Mesenteric Lymph Node Involvement in Patients with Ovarian Cancer 国際誌

    Yoshifumi Shimada, Kana Tanaka, Koji Nishino, Kosuke Yoshihara, Masato Nakano, Hitoshi Kameyama, Takayuki Enomoto, Toshifumi Wakai

    Annals of Surgical Oncology   28 ( 12 )   7614 - 7615   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1245/s10434-021-09919-7

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    その他リンク: http://link.springer.com/article/10.1245/s10434-021-09919-7/fulltext.html

  • How Does Endometriosis Lead to Ovarian Cancer? The Molecular Mechanism of Endometriosis-Associated Ovarian Cancer Development. 国際誌

    Nozomi Yachida, Kosuke Yoshihara, Manako Yamaguchi, Kazuaki Suda, Ryo Tamura, Takayuki Enomoto

    Cancers   13 ( 6 )   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Numerous epidemiological and histopathological studies support the notion that clear cell and endometrioid carcinomas derive from ovarian endometriosis. Accordingly, these histologic types are referred to as "endometriosis-associated ovarian cancer" (EAOC). Although the uterine endometrium is also considered an origin of endometriosis, the molecular mechanism involved in transformation of the uterine endometrium to EAOC via ovarian endometriosis has not yet been clarified. Recent studies based on high-throughput sequencing technology have revealed that cancer-associated gene mutations frequently identified in EAOC may exist in the normal uterine endometrial epithelium and ovarian endometriotic epithelium. The continuum of genomic alterations from the uterine endometrium to endometriosis and EAOC has been described, though the significance of cancer-associated gene mutations in the uterine endometrium or endometriosis remains unclear. In this review, we summarize current knowledge regarding the molecular characteristics of the uterine endometrium, endometriosis, and EAOC and discuss the molecular mechanism of cancer development from the normal endometrium through endometriosis in an effort to prevent EAOC.

    DOI: 10.3390/cancers13061439

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  • Establishment of in vitro 3D spheroid cell cultivation from human gynecologic cancer tissues. 国際誌

    Haruka Ueda, Yutaro Mori, Kaoru Yamawaki, Tatsuya Ishiguro, Hirokazu Ohata, Ai Sato, Kentaro Sugino, Nozomi Yachida, Manako Yamaguchi, Kazuaki Suda, Ryo Tamura, Kosuke Yoshihara, Koji Okamoto, Takayuki Enomoto

    STAR protocols   2 ( 1 )   100354 - 100354   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Advanced-stage gynecologic cancer remains a life-threatening disease. Here, we present a protocol for establishment of stable in vitro 3D spheroid cells derived from human uterine endometrial and ovarian cancer tissues. The tumor-derived spheroid cells have cancer stem cell-related characteristics, including tumorigenesis, and can be used for biological and biochemical analyses and drug efficacy assays. Because these cells possess the biological characteristics of original human tumors, spheroid cells and spheroid-derived xenografts will have applications in personalized medicine in the future. For complete details on the use and execution of this protocol, please refer to Ishiguro et al. (2016) and Mori et al. (2019).

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  • Surgical margin status and recurrence pattern in invasive vulvar Paget's disease: A Japanese Gynecologic Oncology Group study. 国際誌

    Koji Matsuo, Shin Nishio, Shinya Matsuzaki, Haruko Iwase, Seiji Kagami, Shu Soeda, Hirokazu Usui, Ryutaro Nishikawa, Mikio Mikami, Takayuki Enomoto

    Gynecologic oncology   160 ( 3 )   748 - 754   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To examine the association between surgical margin status and recurrence pattern in invasive vulvar Paget's disease. METHODS: This is a preplanned secondary analysis of a previously organized nationwide retrospective study in Japan (JGOG-1075S). Women with stage I-IV invasive vulvar Paget's disease who received surgical treatment from 2001-2010 were examined (n=139). Multivariable analysis was performed to assess local-recurrence, distant-recurrence, and all-cause mortality based on surgical margin status. RESULTS: The median age was 70 years. The majority had stage I disease (61.2%), and the median tumor size was 5.0cm. Nodal metastasis was observed in 15.1%. Simple vulvectomy (46.0%) was the most common surgery type followed by radical vulvectomy (28.1%). More than half received vulvar reconstructive surgery (59.0%). Positive surgical margin was observed in 35.3%, and close margin <1cm was observed in 29.5%. Vulvectomy type was not associated with surgical margin status (P=0.424). The median follow-up was 5.8 years. Positive surgical margin was associated with increased local-recurrence (5-year cumulative rates for positive versus negative margin: 35.8% versus 15.0%, P=0.010) but not distant-recurrence (18.3% versus 16.0%, P=0.567). Positive surgical margin was also associated with increased all-cause mortality (5-year overall survival rates for positive versus negative margin: 72.6% versus 88.2%, P=0.032). In multivariable analysis, positive surgical margin remained an independent factor associated with increased risk of local-recurrence (hazard ratio 2.80, 95% confidence interval 1.18-6.63) and all-cause mortality (hazard ratio 2.87, 95% confidence interval 1.20-6.83). CONCLUSION: Positive surgical margin appears to be common in invasive vulvar Paget's disease that is associated with increased local-recurrence and all-cause mortality risks. Role of alternative surgical technique or adjuvant therapy merits further investigation to improve local disease control.

    DOI: 10.1016/j.ygyno.2020.12.023

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  • HPV16型感染が確認されながらp16免疫染色が陰性であったVIN3の若年症例

    櫛谷 直寿, 小林 暁子, 工藤 梨沙, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 295   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • オンライン内視鏡外科教育実践の共有 オンライン教育コミュニティの構築

    磯部 真倫, 榎本 隆之

    日本内視鏡外科学会雑誌   25 ( 7 )   BSP2 - 3   2021年3月

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    記述言語:日本語   出版者・発行元:(一社)日本内視鏡外科学会  

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  • 当院における腹腔鏡下仙骨腟固定術の検討

    島 英里, 小林 暁子, 黒澤 めぐみ, 明石 英彦, 石黒 竜也, 安達 聡介, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 554   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • オンライン内視鏡外科教育実践の共有 オンライン教育コミュニティの構築

    磯部 真倫, 榎本 隆之

    日本内視鏡外科学会雑誌   25 ( 7 )   BSP3 - 3   2021年3月

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    記述言語:日本語   出版者・発行元:(一社)日本内視鏡外科学会  

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  • MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells 査読 国際誌

    Takahiko Murayama, Yasuto Takeuchi, Kaoru Yamawaki, Toyoaki Natsume, Mengjiao Li, Rojas‐Chaverra N. Marcela, Tatsunori Nishimura, Yuta Kogure, Asuka Nakata, Kana Tominaga, Asako Sasahara, Masao Yano, Satoko Ishikawa, Tetsuo Ohta, Kazuhiro Ikeda, Kuniko Horie‐Inoue, Satoshi Inoue, Masahide Seki, Yutaka Suzuki, Sumio Sugano, Takayuki Enomoto, Masahiko Tanabe, Kei‐ichiro Tada, Masato T. Kanemaki, Koji Okamoto, Arinobu Tojo, Noriko Gotoh

    Cancer Science   112 ( 3 )   1209 - 1224   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    Cancer stem-like cells (CSCs) induce drug resistance and recurrence of tumors when they experience DNA replication stress. However, the mechanisms underlying DNA replication stress in CSCs and its compensation remain unclear. Here, we demonstrate that upregulated c-Myc expression induces stronger DNA replication stress in patient-derived breast CSCs than in differentiated cancer cells. Our results suggest critical roles for mini-chromosome maintenance protein 10 (MCM10), a firing (activating) factor of DNA replication origins, to compensate for DNA replication stress in CSCs. MCM10 expression is upregulated in CSCs and is maintained by c-Myc. c-Myc-dependent collisions between RNA transcription and DNA replication machinery may occur in nuclei, thereby causing DNA replication stress. MCM10 may activate dormant replication origins close to these collisions to ensure the progression of replication. Moreover, patient-derived breast CSCs were found to be dependent on MCM10 for their maintenance, even after enrichment for CSCs that were resistant to paclitaxel, the standard chemotherapeutic agent. Further, MCM10 depletion decreased the growth of cancer cells, but not of normal cells. Therefore, MCM10 may robustly compensate for DNA replication stress and facilitate genome duplication in cancer cells in the S-phase, which is more pronounced in CSCs. Overall, we provide a preclinical rationale to target the c-Myc-MCM10 axis for preventing drug resistance and recurrence of tumors.

    DOI: 10.1111/cas.14776

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.14776

  • 完全直腸脱を伴うstage IV骨盤臓器脱に対して腹腔鏡下直腸固定術と同時に腹腔鏡下仙骨腟固定術を行った2症例

    春谷 千智, 小林 暁子, 明石 英彦, 鈴木 美保, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 2 )   81 - 85   2021年3月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    症例1は80歳で、約2年前から子宮下垂感を自覚し、約1年前から排便時に直腸脱を認めるようになった。今回、Stage IVの子宮脱および完全直腸脱の診断で一期的根治手術を行う方針となり、腹腔鏡下にWells直腸後方固定術+子宮腟上部切断+両側付属器切除+シングルメッシュによる仙骨腟固定術を施行し、術後経過良好であった。症例2は78歳で、約2年前から子宮脱を自覚し、間欠的自己還納で対応していた。半年前に排尿困難感が出現し、手術目的で当科を紹介受診した。初回受診時は子宮脱のみであったが、2回目の診察で直腸脱の併発を認めた。今回、Stage IVの子宮脱および完全直腸脱の診断で症例1と同様の手術を行い、術後経過良好であった。

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  • クロミフェンクエン酸塩療法後のheterotopic pregnancyに対する腹腔鏡下手術経験

    石黒 竜也, 櫛谷 直寿, 齋藤 宏美, 工藤 梨沙, 茅原 誠, 西野 幸治, 小林 暁子, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 2 )   137 - 137   2021年3月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 当院における子宮頸癌IからII期の治療方針に関する検討

    鈴木 美保, 西川 伸道, 山口 真奈子, 新井 龍寿, 明石 絵里菜, 安達 聡介, 吉原 弘祐, 小林 暁子, 西野 幸治, 山口 雅幸, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 307   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 当院における卵巣癌・卵管癌・腹膜癌に対するBevacizumabの使用経験と有害事象に関する検討

    新井 龍寿, 明石 絵里菜, 鈴木 美保, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 327   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 妊娠子宮破裂と診断された5症例

    為我井 加菜, 須田 一暁, 関根 正幸, 小林 琢也, 廣川 哲太郎, 長谷川 順紀, 奈良本 葉月, 山脇 芳, 南川 高廣, 能仲 太郎, 五日市 美奈, 西島 浩二, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 2 )   75 - 80   2021年3月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    妊娠中の子宮破裂は母児ともに重篤な状態を招きやすい病態であるが、特徴的な臨床所見や徴候について明確な知見がなく、早期診断が困難である。今回、当院で過去15年間に子宮破裂と診断された5症例について臨床所見と母児の転帰を中心に検討した。臨床的背景として、4例が高齢妊娠、うち1例は多産婦であった。特徴的な臨床所見として、陣痛とは異なる腹痛を3例、分娩前の異常出血を2例に認めた。子宮収縮の特徴的な所見として、陣痛減弱を1例に認め、他の1例に子宮頻収縮を認めた。母体の転帰として、輸血を要したものが3例あり、うち1例は出血コントロールが困難で子宮全摘術を施行された。児の転帰は、長期予後を調査しえた4例すべてが転帰良好であった。

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  • 【ワクチンの安全性と社会学-HPVワクチンの接種はなぜ広まらないのか?-】HPVワクチンについて HPVワクチンの有効性 最近の動向

    関根 正幸, 工藤 梨沙, 山口 真奈子, 安達 聡介, 黒澤 めぐみ, 榎本 隆之

    産婦人科の実際   70 ( 3 )   285 - 291   2021年3月

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    記述言語:日本語   出版者・発行元:金原出版(株)  

    <文献概要>HPVワクチンの積極的勧奨が中止されて8年が経過しようとしている。HPVワクチン接種者が検診年齢である20歳に到達したことで,HPV感染率の低下だけでなく,細胞診異常と組織診異常の低下も報告されてきている。NIIGATA STUDYではHPV16/18型感染に対する高い有効性に加え,HPV31/45/52型に対する交叉防御効果が示され,厚生労働科学研究費補助金 上田班とAMED榎本班のJ Studyでは,それぞれCIN3以上の減少効果,CIN2以上の減少効果が示された。海外では,スウェーデンから世界で初めて浸潤子宮頸癌の減少効果が報告され,わが国でも浸潤癌に対するデータの検証が待たれている。

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  • Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women. 国際誌

    Manako Yamaguchi, Masayuki Sekine, Sharon J B Hanley, Risa Kudo, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Takayuki Enomoto

    Scientific reports   11 ( 1 )   2898 - 2898   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on sexual behavior and the risk of high-grade cervical disease in a Japanese population. This study investigates sexual behavior and the risk of HPV infection and cervical disease in 3968 women aged 20-41 yrs undergoing cervical screening between April 2014 and March 2016. Mean age at first intercourse was 18.4 yrs ± 2.8 and 32% of women reported ≥ 6 lifetime sexual partners. In regression analyses, number of partners was a significant risk factor for HPV infection. However, for high-grade disease (CIN2+), when HPV genotype was adjusted for, number of partners was not statistically significant. The greatest risk factor was an HPV16/18 infection (adjusted odds ratio 113.7, 95% CI: 40.8-316.9). In conclusion, we found that having an HPV16/18 infection and not sexual behavior was the most significant risk factor for high grade cervical disease in young Japanese women. These infections can be prevented by a highly effective vaccine and we recommend that the Japanese government resume proactive recommendations for the HPV vaccine immediately.

    DOI: 10.1038/s41598-021-82354-6

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  • The disease sites of female genital cancers of BRCA1/2-associated hereditary breast and ovarian cancer: a retrospective study. 国際誌

    Takashi Mitamura, Masayuki Sekine, Masami Arai, Yuka Shibata, Momoko Kato, Shiro Yokoyama, Hiroko Yamashita, Hidemichi Watari, Ichiro Yabe, Hiroyuki Nomura, Takayuki Enomoto, Seigo Nakamura

    World journal of surgical oncology   19 ( 1 )   36 - 36   2021年2月

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    記述言語:英語  

    Disease sites of female genital tract cancers of BRCA1/2-associated hereditary breast and ovarian cancer (HBOC) are less understood than non-hereditary cancers. We aimed to elucidate the disease site distribution of genital cancers in women with the germline BRCA1 and BRCA2 pathogenic variants (BRCA1+ and BRCA2+) of HBOC. For the primary disease site, the proportion of fallopian tube and peritoneal cancer was significantly higher in BRCA2+ (40.5%) compared with BRCA1+ (15.4%) and BRCA- (no pathogenic variant, 12.8%). For the metastatic site, the proportion of peritoneal dissemination was significantly higher in BRCA1+ (71.9%) than BRCA- (55.1%) and not different from BRCA2+ (71.4%). With one of the most extensive patients, this study supported the previous reports showing that the pathogenic variants of BRCA1/2 were involved in the female genitalia's disease sites.

    DOI: 10.1186/s12957-021-02151-3

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  • Internet Survey of Awareness and Behavior Related to HPV Vaccination in Japan. 国際誌

    Risa Kudo, Masayuki Sekine, Manako Yamaguchi, Megumi Hara, Sharon J B Hanley, Yutaka Ueda, Asami Yagi, Sosuke Adachi, Megumi Kurosawa, Etsuko Miyagi, Takayuki Enomoto

    Vaccines   9 ( 2 )   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears in Japan. We aimed to clarify the differences between vaccinated and unvaccinated females in their awareness, knowledge, and behaviors toward cervical cancer, HPV vaccination and sex. Questionnaires were administered online to women aged 16 to 20. We conducted investigations for the following: awareness, knowledge, and actions for cervical cancer, HPV vaccination, and sexual activity, as well as items related to participants' social background. The survey in 828 girls revealed three points. The first is that more than half of the surveyed Japanese girls had poor knowledge about cervical cancer screening, HPV, or HPV vaccines. The second is that those in the unvaccinated group had a particularly poor knowledge of the subject and tended to have higher sexual activity. The final is that only 0.5% of the girls experienced changes in awareness about sexual activity after vaccination. In conclusion, this is the first large-scale survey analyzing the association between HPV vaccination and sexual activity in Japanese girls. Not only do unvaccinated girls not benefit from vaccines, but they also tend to engage in high-risk sexual behavior, and thus it is even more important to provide information on the effectiveness of vaccines and the usefulness of cancer screening.

    DOI: 10.3390/vaccines9020087

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  • HPVワクチン有効性評価 全国自治体症例対照研究

    池田 さやか, 上田 豊, 原 めぐみ, 八木 麻未, 北村 哲久, 喜多村 祐里, 小西 宏, 垣添 忠生, 関根 正幸, 榎本 隆之, 祖父江 友孝

    Journal of Epidemiology   31 ( Suppl. )   89 - 89   2021年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • プラチナ抵抗性再発卵巣癌に対するベバシズマブ2週間隔投与の使用実態調査

    関根 正幸, 榎本 隆之, 渡部 洋, 片渕 秀隆, 八重樫 伸生, 青木 大輔

    日本婦人科腫瘍学会雑誌   39 ( 1 )   406 - 406   2021年1月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • Impact of lymphadenectomy on the treatment of endometrial cancer using data from the JSOG cancer registry. 国際誌

    Keiko Saotome, Wataru Yamagami, Hiroko Machida, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Daisuke Aoki, Mikio Mikami

    Obstetrics & gynecology science   64 ( 1 )   80 - 89   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Regional lymph node (LN) dissection is a standard surgical procedure for endometrial cancer, but there is currently no clear consensus on its therapeutic significance. We aimed to determine the impact of regional LN dissection on the outcome of endometrial cancer. METHODS: Study subjects comprised 36,813 patients who were registered in the gynecological tumor registry of the Japan Society of Obstetrics and Gynecology, had undergone initial surgery for endometrial cancer between 2004 and 2011, and whose clinicopathological factors and prognosis were appropriate for our investigation. The following clinicopathological factors were obtained from the registry: age, surgical stage classification, Union for International Cancer Control tumor, node, metastasis classification, histological type, histological differentiation, presence or absence of LN dissection, and postoperative treatment. We retrospectively analyzed the clinicopathological factors and therapeutic outcomes for patients with endometrial cancer. RESULTS: Analysis of all subjects showed that the group that underwent LN dissection had a significantly better overall survival than the group that did not undergo dissection. Analysis based on stage showed similar results across groups, except for stage Ia. Analysis based on stage and histological type showed similar results across groups, except for stage Ia endometrial carcinoma G1 or Ia G2. Multivariate analysis of prognostic factors indicated that LN dissection is an independent prognostic factor and that it has a greater impact on prognosis than adjuvant chemotherapy. CONCLUSION: Despite the limitations of a retrospective study with some biases, the results suggest that LN dissection in endometrial cancer has a prognostic effect.

    DOI: 10.5468/ogs.20186

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  • 腹腔鏡下仙骨腟固定術における後壁修復の術式検討

    明石 英彦, 小林 暁子, 安達 聡介, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 1 )   46 - 46   2021年1月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 腹腔鏡下試験切除術が診断に有用であった2例

    明石 英彦, 鈴木 美保, 工藤 梨沙, 田村 亮, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 1 )   57 - 57   2021年1月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 同時化学放射線療法中に発症した急性腎障害症例の検討

    鈴木 美保, 関根 正幸, 明石 英彦, 明石 絵里菜, 工藤 梨沙, 田村 亮, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 山口 雅幸, 西川 伸道, 榎本 隆之

    日本婦人科腫瘍学会雑誌   39 ( 1 )   357 - 357   2021年1月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 当科での高頻度マイクロサテライト不安定性(MSI-High)固形癌へのペムブロリズマブ使用の現状

    明石 絵里菜, 吉原 弘祐, 明石 英彦, 鈴木 美保, 工藤 梨沙, 田村 亮, 石黒 竜也, 安達 聡介, 磯部 真倫, 小林 暁子, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   39 ( 1 )   314 - 314   2021年1月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 急激な経過をたどった神経内分泌腫瘍の性格を有する原発不明癌の一例

    工藤 梨沙, 西野 幸治, 明石 英彦, 鈴木 美保, 田村 亮, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   39 ( 1 )   448 - 448   2021年1月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • Direct oral anticoagulant導入後の婦人科悪性腫瘍に合併した静脈血栓症の管理

    田村 亮, 西川 伸道, 鈴木 美保, 明石 英彦, 明石 絵里菜, 工藤 梨沙, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 山口 雅幸, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   39 ( 1 )   437 - 437   2021年1月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 急性腹症を契機に判明したOHVIRA症候群の1例

    工藤 梨沙, 小林 暁子, 明石 英彦, 鈴木 美保, 田村 亮, 石黒 竜也, 安達 聡介, 吉原 弘佑, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 1 )   39 - 39   2021年1月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 治療経過中にSIADHを発症した子宮頸部小細胞癌の1例

    渡部 はるか, 工藤 梨沙, 明石 英彦, 鈴木 美保, 田村 亮, 石黒 竜也, 安達 聡介, 吉原 弘佑, 磯部 真倫, 小林 暁子, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 1 )   35 - 35   2021年1月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 腹腔鏡下手術におけるセプラフィルム体腔内挿入および貼付の工夫

    鈴木 美保, 小林 暁子, 黒澤 めぐみ, 明石 英彦, 明石 絵里菜, 工藤 梨沙, 田村 亮, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 1 )   51 - 51   2021年1月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 腹腔鏡下手術におけるセプラフィルム体腔内搬入および貼付法の工夫 Endoロールの使用経験

    鈴木 美保, 小林 暁子, 黒澤 めぐみ, 明石 英彦, 明石 絵里菜, 工藤 梨沙, 田村 亮, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 1 )   1 - 6   2021年1月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    セプラフィルムは優れた癒着防止効果が報告されているが、腹腔鏡下手術での体腔内搬入や貼付操作に難渋することが多い。今回、セプラフィルムの操作にEndoロールを用いた方法を試行し、その有効性について従来法(リデューサーを用いる方法)と比較検討した。腹腔鏡下単純子宮全摘出術3例にEndoロールを使用した結果、3例とも充填が比較的簡便に途中で破損することなく可能であった。最も優れていた点は、5mmポートから挿入可能なため、カメラで確認しながら安全に体腔内搬入でき、周囲臓器にセプラフィルムが付着する前に、広がったままの状態で受け取ることにより貼付が容易な点であった。

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  • 遺伝性乳癌卵巣癌に対する新しい分子標的薬とリスク低減手術

    関根 正幸, 西野 幸治, 山口 雅幸, 榎本 隆之

    新潟県医師会報   ( 850 )   12 - 17   2021年1月

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    記述言語:日本語   出版者・発行元:新潟県医師会  

    新しい分子標的薬であるPARP阻害薬は、生殖細胞系列のBRCA1/2遺伝子変異を原因とする遺伝性乳癌卵巣癌(Hereditary Breast and Ovarian Cancer:HBOC)患者に高い感受性を示すことから多くの臨床試験が行われた結果、今では臓器横断的に相同組換え修復異常(homologous recombination deficiency:HRD)を示す癌に対して臨床現場で普及し始めている。再発卵巣癌治療では、PARP阻害薬オラパリブの感受性を予測する臨床的な感受性サロゲートマーカーとしてプラチナ感受性が用いられ、卵巣癌の初回治療ではBRCA1/2遺伝子検査がコンパニオン診断として保険適応となっている。さらに、HBOCの乳癌あるいは卵巣癌患者に対する予防診療が2020年4月より保険収載された。上記の保険承認により婦人科癌の治療が一気に変化しつつある。本稿ではHBOCをターゲットにしたゲノム医療の進展と、ゲノム情報に基づく先制医療の現状と展望について概説する。(著者抄録)

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  • 当科における腹腔鏡下仙骨腟固定術の治療成績

    明石 英彦, 小林 暁子, 春谷 千智, 明石 絵里菜, 鈴木 美保, 工藤 梨沙, 田村 亮, 安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   115 ( 1 )   25 - 30   2021年1月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    骨盤臓器脱に対して2018年6月〜2020年2月に腹腔鏡下仙骨腟固定術を行った31例のうち、直腸脱の同時手術を行った2例を除く29例を対象とし、「手術時間」「術中出血量」「術中・術後合併症」「再発の有無」「術前後の排尿機能」などについて検討した。手術時間は128〜256分(中央値199分)、出血量は5〜10mL(中央値5mL)であった。術中合併症は認めなかった。術後合併症として腹腔内感染を1例に認めたが保存的治療で改善した。再発は1例に認め、再発部位はメッシュ固定部位以外の後壁であり、追加手術は要しなかった。排尿機能はOABSSとIPSSで評価し、術前のOABSSは軽症(5点以下)5例、中等症(6〜11点)6例、術後のOABSSは軽症1例、中等症1例、重症(12点以上)1例であった。術前のIPSSは軽症(0〜7点)50%、中等症(8〜19点)35%、重症(20〜35点)15%、術後のIPSSは軽症81%、中等症15%、重症4%であった。

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  • Factor Structure and Measurement Invariance of the Hospital Anxiety and Depression Scale Across the Peripartum Period Among Pregnant Japanese Women. 国際誌

    Maki Ogawa, Yuichiro Watanabe, Takaharu Motegi, Naoki Fukui, Koyo Hashijiri, Ryusuke Tsuboya, Takuro Sugai, Jun Egawa, Rie Araki, Kazufumi Haino, Masayuki Yamaguchi, Koji Nishijima, Takayuki Enomoto, Toshiyuki Someya

    Neuropsychiatric disease and treatment   17   221 - 227   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Purpose: The Hospital Anxiety and Depression Scale (HADS) is a self-report questionnaire widely used to assess anxiety and depression. To the best of our knowledge, only four studies have examined the factor structure of the HADS for assessing pregnant women, with conflicting results. This study aimed to assess the factor structure and measurement invariance of the HADS for use with pregnant Japanese women. Participants and Methods: A total of 936 pregnant Japanese women completed the HADS questionnaire at three time points: the first and third trimester of pregnancy, and postpartum. We examined the factor structure of the HADS in Group 1 (n = 466) using exploratory factor analysis (EFA). We then compared the models identified in Group 1 with those from previous studies using confirmatory factor analysis (CFA) in Group 2 (n = 470). We performed multiple-group CFA for Group 2 to test the measurement invariance of the best-fit model across the three time points. Results: The EFA for the Group 1 data at the three time points revealed a two-factor model. In the CFA, the two-factor model from Group 1 showed the best fit with the data at the three time points. In the multiple-group CFA for Group 2, we confirmed the configural and metric invariance of the two-factor model across the three time points. Conclusion: Our findings provide evidence for a two-factor structure and weak measurement invariance of the HADS in pregnant Japanese women during the peripartum period.

    DOI: 10.2147/NDT.S294918

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  • The validity of the subsequent pregnancy index score for fertility-sparing trachelectomy in early-stage cervical cancer

    Takashi Iwata, Hiroko Machida, Koji Matsuo, Kaoru Okugawa, Tsuyoshi Saito, Kyoko Tanaka, Kenichiro Morishige, Hiroaki Kobayashi, Kiyoshi Yoshino, Hideki Tokunaga, Tomoaki Ikeda, Makio Shozu, Nobuo Yaegashi, Takayuki Enomoto, Mikio Mikami

    Fertility and Sterility   2021年

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    掲載種別:研究論文(学術雑誌)  

    © 2020 American Society for Reproductive Medicine Objective: To evaluate timing and a prediction model for pregnancy in early-stage cervical cancer patients who underwent fertility-sparing trachelectomy. Design: Retrospective cohort. Setting: Academic multicenter. Patient(s): Women ages <45 years with clinical stage I–II cervical cancer were enrolled between 2009 and 2013 (n = 393). Intervention(s): Planned fertility-sparing trachelectomy. Main Outcome Measure(s): Cumulative incidences and clinicopathological characteristics of those who developed subsequent pregnancy were examined. Result(s): There were 77 (21.6%) women who had subsequent pregnancies after fertility-sparing trachelectomy with 1-, 2-, and 5-year cumulative pregnancy rates of 2.8%, 6.2%, and 17.4%, respectively. The median time to develop subsequent pregnancy was 3.2 years. In a competing risk analysis, women had a higher risk of recurrent cancer than conception during the first 11 months postsurgery. On multivariable analysis, younger age, being married, and postoperative reproductive treatment were independently associated with an increased chance of developing a subsequent pregnancy. The subsequent pregnancy index (SPI) score to predict the likelihood of having pregnancy was proposed, and it was calculated based on age, marital status, and reproductive treatment (2, 2, and 4 points, respectively). Women with a higher SPI score had significantly higher subsequent pregnancy rates (5-year pregnancy rate; the score was 3 in 4.7% of cases; 4 to 5 in 11.3%; 6 to 7 in 27.4%; and 8 in 50.8%), but they had similar recurrence rates (5.0%). Conclusion(s): The SPI score proposed in our study is useful in predicting subsequent pregnancy in women with early-stage cervical cancer undergoing fertility-sparing trachelectomy.

    DOI: 10.1016/j.fertnstert.2020.09.162

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  • Identification of Bonding Difficulties in the Peripartum Period Using the Mother-to-Infant Bonding Scale-Japanese Version and Its Tentative Cutoff Points. 国際誌

    Koyo Hashijiri, Yuichiro Watanabe, Naoki Fukui, Takaharu Motegi, Maki Ogawa, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

    Neuropsychiatric disease and treatment   17   3407 - 3413   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Purpose: Identification of pregnant women with bonding difficulties is important to provide early intervention. However, few studies have examined the utility of self-report questionnaires that assess mother-infant bonding as screening tools for bonding difficulties. This longitudinal study aimed to identify pregnant women with bonding difficulties using the Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) and to estimate its optimal cutoff points in the peripartum period. Patients and Methods: A total of 1301 pregnant women completed the MIBS-J and Hospital Anxiety and Depression Scale (HADS) at three time points: first trimester (T1; approximately 12-15 weeks gestation), third trimester (T2; approximately 30-34 weeks gestation), and postpartum (T3; approximately 4 weeks postpartum). A two-step cluster analysis was conducted to classify pregnant women based on their MIBS-J subscale scores at the three time points. Based on the cluster analysis results, receiver operating characteristic curve analysis was performed to estimate the optimal cutoff scores for the MIBS-J total score at each time point. Results: The two-step cluster analysis produced two clusters: Cluster 1 (n = 824) and Cluster 2 (n = 477). Both the MIBS-J and HADS scores were significantly higher in Cluster 2 than in Cluster 1 at all time points. The MIBS-J tentative cutoff points were 3/4, 3/4, and 2/3 at T1, T2, and T3, respectively. Conclusion: We identified two distinct groups across the perinatal period: pregnant women with bonding difficulties and pregnant women with normal bonding. Our findings suggest the usefulness of the MIBS-J as a screening tool to identify bonding difficulties during pregnancy.

    DOI: 10.2147/NDT.S336819

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  • Risk factors for lymph node metastasis of ovarian, fallopian tube and primary peritoneal cancer in hereditary breast and ovarian cancer syndrome. 国際誌

    Takashi Mitamura, Masayuki Sekine, Masami Arai, Yuka Shibata, Momoko Kato, Shiro Yokoyama, Hiroko Yamashita, Hidemichi Watari, Ichiro Yabe, Hiroyuki Nomura, Takayuki Enomoto, Seigo Nakamura

    Japanese journal of clinical oncology   50 ( 12 )   1380 - 1385   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: To establish an individualized surgical strategy for lymphadenectomy in ovarian cancer patients with the germline BRCA1 and BRCA2 pathogenic variants (BRCA1+ and BRCA2+), we investigated the clinicopathological characteristics that are involved in the increased risk of lymph node metastasis. METHODS: We retrospectively reviewed the data of Japanese women registered in the database of the Japanese Hereditary Breast and Ovarian Cancer Consortium, who underwent BRCA1 and BRCA2 genetic testing. RESULTS: We evaluated the predictors of lymph node metastasis in all patients with the information of age at the diagnosis, disease site, histological subtype, 2014 FIGO stage, personal breast cancer history and family history; 233, 153 and 32 patients in the BRCA- (no pathogenic variant), BRCA1+ and BRCA2+ groups, respectively. The prevalence of lymph node metastasis was not markedly different between BRCA- (20.0%), BRCA1+ (18.4%) and BRCA2+ (26.2%). Multivariate analysis revealed an absence of a family history of ovarian cancer as an independent predictor for an increased risk of lymph node metastasis in BRCA1+, and the prevalence of lymph node metastasis was 11.7 and 42.0% in the groups with and without a family history of ovarian cancer, respectively. This subgroup without a family history of ovarian cancer did not show any correlation with a particular variant of BRCA1, including two common variants of c.188 T > A and c.2800C > T. CONCLUSIONS: This study suggested that certain genetic factors related to the penetrance of hereditary breast and ovarian cancer syndrome altered the frequency of lymph node metastasis in BRCA1+ ovarian cancer, and family history may be useful to personalize the indication of lymphadenectomy.

    DOI: 10.1093/jjco/hyaa124

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  • Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-like Cells using the Three-dimensional Co-culture System, NICO-1. 国際誌

    Yuko Miyagawa, Kazunori Nagasaka, Kaoru Yamawaki, Yutaro Mori, Tatsuya Ishiguro, Kei Hashimoto, Ryoko Koike, Siho Fukui, Takeru Sugihara, Takayuki Ichinose, Haruko Hiraike, Koichiro Kido, Koji Okamoto, Takayuki Enomoto, Takuya Ayabe

    Journal of visualized experiments : JoVE   ( 166 )   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Cancer stem cells (CSCs) reside in a supportive niche, constituting a microenvironment comprised of adjacent stromal cells, vessels, and extracellular matrix. The ability of CSCs to participate in the development of endothelium constitutes an important characteristic that directly contributes to the general understanding of the mechanisms of tumorigenesis and tumor metastasis. The purpose of this work is to establish a reproducible methodology to investigate the tumor-initiation capability of ovarian cancer stem cells (OCSCs). Herein, we examined the neovascularization mechanism between endothelial cells and OCSCs along with the morphological changes of endothelial cells using the in vitro co-culture model NICO-1. This protocol allows visualization of the neovascularization step surrounding the OCSCs in a time course manner. The technique can provide insight regarding the angiogenetic properties of OCSCs in tumor metastasis.

    DOI: 10.3791/61751

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  • ARID1A protein expression is retained in ovarian endometriosis with ARID1A loss-of-function mutations: implication for the two-hit hypothesis

    Nozomi Yachida, Kosuke Yoshihara, Kazuaki Suda, Hirofumi Nakaoka, Haruka Ueda, Kentaro Sugino, Manako Yamaguchi, Yutaro Mori, Kaoru Yamawaki, Ryo Tamura, Tatsuya Ishiguro, Masanori Isobe, Teiichi Motoyama, Ituro Inoue, Takayuki Enomoto

    Scientific Reports   10 ( 1 )   2020年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1038/s41598-020-71273-7

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    その他リンク: http://www.nature.com/articles/s41598-020-71273-7

  • The post-progression survival of patients with recurrent or persistent ovarian clear cell carcinoma: results from a randomized phase III study in JGOG3017/GCIG. 国際誌

    Eiji Kondo, Tsutomu Tabata, Nao Suzuki, Daisuke Aoki, Hideaki Yahata, Yoshio Kotera, Osamu Tokuyama, Keiichi Fujiwara, Eizo Kimura, Fumitoshi Terauchi, Toshiyuki Sumi, Aikou Okamoto, Nobuo Yaegashi, Takayuki Enomoto, Toru Sugiyama

    Journal of gynecologic oncology   31 ( 6 )   e94   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: In this study we sought to investigate the clinical factors that affect post-progression survival (PPS) in patients with recurrent or persistent clear cell carcinoma (CCC). We utilized the JGOG3017/Gynecological Cancer InterGroup data to compare paclitaxel plus carboplatin (TC) and irinotecan plus cisplatin (CPT-P) in the treatment of stages I to IV CCC. METHODS: We enrolled 166 patients with recurrent or persistent CCC and assessed the impact of variables, including platinum sensitivity, treatment arm, crossover chemotherapy, primary stage, residual tumor at primary surgery, performance status, ethnicity, and tumor reduction surgery at recurrence on the median of PPS in patients with recurrent or persistent CCC. RESULTS: A total of 77 patients received TC, and 89 patients received CPT-P. The median PPS for patients with platinum-resistant disease was 10.9 months, compared with 18.8 months for patients with platinum-sensitive disease (hazard ratio [HR]=1.88; 95% confidence interval [CI]=1.30-2.72; log-rank p<0.001). In the multivariate analysis, the platinum sensitivity (resistant vs. sensitivity; HR=1.60; p=0.027) and primary stage (p=0.009) were identified as independent predictors of prognosis factors for PPS in recurrent or persistent CCC. CONCLUSIONS: Our findings revealed that platinum sensitivity and primary stage are clinical factors that significantly affect PPS in patients with recurrent or persistent CCC as well as other histologic subtypes of ovarian cancer. PPS in patients with recurrent CCC should establish the basis for future clinical trials in this population.

    DOI: 10.3802/jgo.2020.31.e94

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  • Investigation of clinicopathological features of vulvar cancer in 1068 patients: A Japanese Gynecologic Oncology Group (JGOG) nationwide survey study. 国際誌

    Shin Nishio, Kenta Murotani, Sari Nakao, Motoki Takenaka, Shiro Suzuki, Yoichi Aoki, Yukiharu Todo, Masayoshi Hosaka, Hidekatsu Nakai, Hidetaka Katabuchi, Hirotaka Nishi, Munetaka Takekuma, Mikio Mikami, Takayuki Enomoto

    Gynecologic oncology   159 ( 2 )   449 - 455   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Vulvar cancer is a rare malignancy in the aging population, and optimizing treatment strategies requires large-scale investigation of the clinicopathological features of this disease. In Japan, no such surveys have been conducted in the past 30 years. This large-scale retrospective multi-center study aimed to examine the clinicopathological features of vulvar cancer in Japan. METHODS: Upon obtaining ethical approval by the participating institutions' review boards, the medical records of patients with vulvar cancer, who were treated between 2001 and 2010 were reviewed. The impact of clinicopathological factors on overall survival (OS) was investigated using a multivariate Cox regression model. RESULTS: After applying the inclusion and exclusion criteria, 1068 patients treated in 108 centers were included. The median age was 72 years. The disease was in stage I in 402 patients (37.6%), stage II in 249 patients (23.3%), stage III in 252 patients (23.6%), and stage IV in 165 patients (15.4%). Squamous cell carcinoma, Paget's disease, adenocarcinoma, and other diseases were diagnosed in 773 (72.4%), 154 (14.4%), 59 (5.5%), and 82 (7.7%) patients, respectively. Positive inguino-femoral lymph nodes were found in 265 (24.8%) patients. The 5-year OS rate for stage I, II, III, and IV vulvar cancer were 85.6%, 75.1%, 48.8%, and 40.0%, respectively. CONCLUSION: Our study shows that advanced age, disease stage, histological diagnosis, tumor diameter, and lymph node metastases significantly affect the OS of patients with vulvar cancer in Japan.

    DOI: 10.1016/j.ygyno.2020.08.019

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  • 腹腔鏡下付属器摘出により原発卵巣腫瘍を診断することが可能であった進行子宮頸癌の一例

    吉原 弘祐, 西川 伸道, 櫛谷 直寿, 黒澤 めぐみ, 明石 絵里菜, 鈴木 美保, 工藤 梨沙, 田村 亮, 茅原 誠, 石黒 竜也, 安達 聡介, 磯部 真倫, 小林 暁子, 西野 幸治, 山口 雅幸, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 471]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 子宮体部漿液性上皮内癌の診断に腹腔鏡下手術が有用であった一例

    吉原 弘祐, 小林 暁子, 櫛谷 直寿, 黒澤 めぐみ, 明石 絵里菜, 鈴木 美保, 工藤 梨沙, 田村 亮, 茅原 誠, 石黒 竜也, 安達 聡介, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 470]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 子宮体癌の晩期再発の診断に腹腔鏡下手術が有用であった一例

    吉原 弘祐, 明石 英彦, 櫛谷 直寿, 黒澤 めぐみ, 明石 絵里菜, 鈴木 美保, 工藤 梨沙, 田村 亮, 茅原 誠, 石黒 竜也, 安達 聡介, 磯部 真倫, 小林 暁子, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 460]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 分娩妄想によるいきみにより完全子宮脱を発症し、腹腔鏡下仙骨腟固定術(LSC)後1年メッシュ固定を維持している1例

    黒澤 めぐみ, 小林 暁子, 明石 英彦, 明石 絵里菜, 鈴木 美保, 工藤 梨沙, 田村 亮, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 500]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 難症例での腹腔鏡下子宮全摘における開腹移行と手術完遂の境界の検討

    工藤 梨沙, 小林 暁子, 櫛谷 直寿, 明石 英彦, 明石 絵里菜, 鈴木 美保, 田村 亮, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 126]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 子宮頸部腫大症例に対する腹腔鏡下子宮全摘出術の解剖学的検討

    鈴木 美保, 小林 暁子, 櫛谷 直寿, 黒澤 めぐみ, 明石 絵里菜, 工藤 梨沙, 田村 亮, 島 英里, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 山口 雅幸, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 178]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 若手医師に対する腹腔鏡手術の教育 地方における婦人科腹腔鏡手術教育の現状と課題

    磯部 真倫, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [SY1 - 6]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 婦人科悪性腫瘍が疑われた41症例に対する審査腹腔鏡の後方視的検討

    田村 亮, 小林 暁子, 櫛谷 直寿, 黒澤 めぐみ, 明石 英彦, 明石 絵里菜, 工藤 梨沙, 鈴木 美保, 島 英里, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 山口 雅幸, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 055]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • ミュラー管発生異常における内視鏡手術 多診療科・多職種による小児泌尿生殖器疾患チーム cloaca board 発足と内視鏡の役割

    小林 暁子, 西川 伸道, 磯部 真倫, 山口 雅幸, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [WS14 - 4]   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case‐control study

    Sayaka Ikeda, Yutaka Ueda, Megumi Hara, Asami Yagi, Tetsuhisa Kitamura, Yuri Kitamura, Hiroshi Konishi, Tadao Kakizoe, Masayuki Sekine, Takayuki Enomoto, Tomotaka Sobue

    Cancer Science   2020年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/cas.14682

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  • Analysis of pathological and clinical characteristics of cervical conization according to age group in Japan. 国際誌

    Isao Murakami, Akiko Ohno, Masae Ikeda, Hiroshi Yamashita, Mikio Mikami, Yoichi Kobayashi, Satoru Nagase, Masatoshi Yokoyama, Takayuki Enomoto, Hidetaka Katabuchi

    Heliyon   6 ( 10 )   e05193   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective: With increased screening, more patients with precancerous or early cervical cancer are now being identified. Age at pregnancy, and thus number of patients requiring fertility preservation, have also increased, resulting in more diagnostic and therapeutic cervical conization (conization) procedures. We here investigated the pathological and clinical characteristics of patients undergoing conization, with a focus on age. The objectives of our study were to identify the risk factors potentially involved in cervical intraepithelial neoplasia (CIN) recurrence or persistence, additional treatment after conization, the effects of conization on pregnancy, and the actual status of conization in Japan. Study design: A "Subcommittee for Investigation of Cervical Conization" within the Gynecologic Oncology Committee in the Japan Society of Obstetrics and Gynecology investigated pathological and clinical characteristics of conization at 205 institutions in Japan. We analyzed pathological and clinical characteristics according to age ≤50 and >50 years. Results: Patients aged 20-40 years accounted for 12904 (87%) of the 14,832 study patients (median: 37 years, range: 16-88 years). However, 1838 (12.4%) were aged >50 years. The commonest post-operative diagnosis was CIN grade 3 in all age groups. Rates of invasive cancer, post-operative detection of more advanced lesions, positive surgical margins, additional treatment, and recurrence were significantly higher in patients aged ≥50 years than those aged <50 years (all p < 0.01), whereas rates of post-operative complications did not differ significantly between age groups. The relationship between cerclage and the incidence of amniorrhexis or premature birth did not differ significantly in any age group. Conclusion: Post-conization management of patients aged ≥50 years requires considering the high rates of detection of more advanced lesions post-operatively, positive surgical margins, and recurrence. Cerclage should not be performed post-conization without careful consideration.

    DOI: 10.1016/j.heliyon.2020.e05193

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  • HPVワクチンの長期的なHPV16型、18型感染予防効果

    黒澤 めぐみ, 関根 正幸, 山口 真奈子, 工藤 梨沙, 安達 聡介, 八木 麻未, 池田 さやか, 上田 豊, 宮城 悦子, 原 めぐみ, ハンリー・シャロン, 榎本 隆之

    日本癌治療学会学術集会抄録集   58回   O15 - 2   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • Potential for cervical cancer incidence and death resulting from Japan's current policy of prolonged suspension of its governmental recommendation of the HPV vaccine. 国際誌

    Asami Yagi, Yutaka Ueda, Satoshi Nakagawa, Sayaka Ikeda, Yusuke Tanaka, Masayuki Sekine, Etsuko Miyagi, Takayuki Enomoto, Tadashi Kimura

    Scientific reports   10 ( 1 )   15945 - 15945   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In 2013, recurrent reports of diverse symptoms occurring in girls after receiving HPV vaccination appeared in Japanese media. The Ministry of Health, Labor and Welfare quickly responded by announcing a temporary suspension of its recommendation for the vaccine. The HPV vaccination rate soon fell to almost zero. In the present study, we calculated the potential future numbers of cervical cancer incidence and death that will be increased by this policy decision. We have assumed that the number of yearly vaccinations is evenly distributed across a daily basis. Future incidence and death increased in females born in FY2000 are estimated to be 3651 and 904, respectively, 4566 and 1130 for those born in FY2001, 4645 and 1150 for those born in FY2002, and 4657 and 1153 for those born in FY2003. In FY2020, the large increase of risks to females born in FY2004 amounts to 12.0 females per day who will now be at a higher risk for acquiring of cervical cancer in their future, and 3.0 females per day newly at risk for future death from that disease in its progressive form. No one should be able to accept this situation. We sincerely ask the government to resume its recommendation for the vaccine as soon as possible.

    DOI: 10.1038/s41598-020-73106-z

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  • Japanese Mothers’ Intention to HPV Vaccinate Their Daughters: How Has It Changed over Time Because of the Prolonged Suspension of the Governmental Recommendation?

    Asami Yagi, Yutaka Ueda, Tatsuo Masuda, Sayaka Ikeda, Takashi Miyatake, Satoshi Nakagawa, Kei Hirai, Tomio Nakayama, Etsuko Miyagi, Takayuki Enomoto, Tadashi Kimura

    Vaccines   8 ( 3 )   502 - 502   2020年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    The trend for cervical cancer in younger women has been increasing recently in Japan. However, as a result of the suspension of governmental recommendation, Japan’s HPV (human papillomavirus) vaccination rate for girls born since 2000 has dropped sharply. We conducted an internet survey in December of 2019, 76 months after the suspension of recommendation, to verify the intention of mothers to inoculate their daughter under current circumstances and compared with our previous surveys and leaflet intervention effect. The rates of mothers who replied that they would “inoculate” were significantly higher at 9 and 23 months, but by 32 months after the suspension the rate was significantly lower (p &lt; 0.05, p &lt; 0.05, p &lt; 0.05, respectively). The rates of the mothers who replied they would not inoculate were significantly lower at 9 months and 23 months, but at 76 months was significantly higher (p &lt; 0.05, p &lt; 0.05, p &lt; 0.05, respectively). We found that intervention with a leaflet that could be used under the current suspension of the governmental recommendation did not increase the mothers’ intention to inoculate their daughters. A leaflet that actively encourages vaccination may increase the intent of vaccination. It is strongly recommended that the MHLW promptly resume its recommendations for HPV vaccination.

    DOI: 10.3390/vaccines8030502

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  • Association of gBRCA1/2 mutation locations with ovarian cancer risk in Japanese patients from the CHARLOTTE study. 国際誌

    Kosuke Yoshihara, Takayuki Enomoto, Daisuke Aoki, Yoh Watanabe, Junzo Kigawa, Nobuhiro Takeshima, Hyoe Inomata, Kana Hattori, Masahisa Jinushi, Hitoshi Tsuda, Toru Sugiyama

    Cancer science   111 ( 9 )   3350 - 3358   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Whether germline (g) breast cancer susceptibility gene (BRCA) mutations are located within or outside the ovarian cancer cluster region (OCCR) (1380-4062 bp for gBRCA1, and between 3249-5681 bp and 6645-7471 bp for gBRCA2) may influence risk variations for ovarian cancers. This ad hoc analysis of the CHARLOTTE epidemiological study in Japan assessed the distribution of gBRCA1/2 mutations in patients with newly diagnosed ovarian cancer, and investigated an association between gBRCA1/2 mutation locations and ovarian cancer risk. Differences in patient background and clinical characteristics in subgroups stratified by gBRCA1/2 mutation locations were also evaluated. We analyzed the data of 93 patients (14.7%) from the CHARLOTTE study who were positive for gBRCA1/2 mutations. After excluding 16 cases with L63X founder mutation, 28 (65.1%) of gBRCA1 mutations were within the OCCR. Of 30 gBRCA2 mutations, 15 (50.0%) were within the OCCR. Of 27 patients (one patient excluded for unknown family history) with gBRCA1 mutations located in the OCCR, 11 (40.7%) had a family history of ovarian cancer; the proportion of patients with a family history of ovarian cancer and gBRCA1 mutations outside the OCCR was lower (13.3%). Sixty percent of patients with gBRCA1 mutations outside the OCCR had a family history of breast cancer; the proportion of patients with a family history of breast cancer and gBRCA1 mutations within the OCCR was relatively lower (33.3%). Understanding the mutation locations may contribute to more accurate risk assessments of susceptible individuals and early detection of ovarian cancer among gBRCA mutation carriers.

    DOI: 10.1111/cas.14513

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  • Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis

    Kazuaki Suda, Luis Antonio Cruz Diaz, Kosuke Yoshihara, Hirofumi Nakaoka, Nozomi Yachida, Teiichi Motoyama, Ituro Inoue, Takayuki Enomoto

    Cancer Science   111 ( 8 )   3000 - 3009   2020年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/cas.14507

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.14507

  • 鏡視下時代の手術教育〜どのように教えるか?〜 NDBオープンデータから見た婦人科腹腔鏡手術の地域間格差とその解決法

    磯部 真倫, 榎本 隆之

    産婦人科手術   ( 31 )   134 - 134   2020年8月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

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  • A survey of 20-year-old Japanese women: how is their intention to undergo cervical cancer screening associated with their childhood HPV vaccination status? 査読 国際誌

    Reisa Kakubari, Tomomi Egawa-Takata, Yutaka Ueda, Yusuke Tanaka, Asami Yagi, Akiko Morimoto, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Noriomi Matsumura, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Risa Kudo, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    Human vaccines & immunotherapeutics   17 ( 2 )   1 - 9   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: In Japan, two groups of women, HPV vaccinated and unvaccinated, are approaching age 20, when they should begin cervical cancer screening. To improve Japan's current poor cervical cancer screening rate, we need to know how these women are thinking about screening. METHODS: We conducted an internet survey of 20-y-old women, exploring their understanding of HPV and cervical cancer screening. We then gave them leaflets with basic information about HPV and cervical cancer, stressing the importance of early detection by screening. We analyzed the leaflet's effects on their attitudes based on their vaccination status. RESULTS: Our study of 618 women found a significantly higher intention for engagement for cervical cancer screening in women HPV-vaccinated as teenagers (29% versus 17%). They were also more aware that: (1) HPV is transmitted by sexual intercourse (49.1% versus 39.2%); (2) the HPV vaccine prevents cervical cancer (49.0% to 34.0%); and (3) the appropriate cervical cancer screening interval is every 2 y (63.3% versus 56.2%). Women in both groups responded well to the leaflet, with significant improvements in intention to receive screening. However, 65%-67% were not swayed. DISCUSSION: HPV-vaccinated women were more knowledgeable about cervical cancer and had a greater intention to receive screening. Our educational leaflet was moderately effective in both groups for increasing intentions to screen, but the majority in both groups were still resistant to screening. CONCLUSION: Japan needs to develop more effective educational programs and tools to vigorously impart the importance of cervical cancer screening.

    DOI: 10.1080/21645515.2020.1788326

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  • Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination

    Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J. B. Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

    Vaccines   8 ( 3 )   425 - 425   2020年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Organized human papillomavirus vaccination (OHPV) in Japan was introduced in 2010 for girls aged 12–16 years who were born in 1994 or later. The rate of OHPV coverage was 70–80%. However, after suspension of the government vaccination recommendation, the coverage dramatically decreased. We aim to investigate the change in prevalence of HPV infection after the initiation of HPV vaccination. We recruited females aged 20–21 years attending public cervical cancer screening from 2014 to 2017 fiscal years (April 2014 to March 2018). Residual Pap test specimens were collected for HPV testing. We compared the prevalence of HPV type-specific infection between women registered in 2014 (born in 1993–1994, including the pre-OHPV generation) and registered in 2015–2017 (born in 1994–1997, the OHPV generation). We collected 2379 specimens. The vaccination coverage figures were 30.7%, 86.6%, 88.4% and 93.7% (p &lt; 0.01) from 2014 to 2017, respectively. The prevalence of HPV16/18 infection significantly decreased from 1.3% in 2014 to 0% in 2017 (p = 0.02). The three most prevalent types were HPV52, 16 and 56 in 2014, and HPV52, 58 and 56 in 2015–2017, respectively. HPV16 and 33 infection rates decreased. On the other hand, the HPV58 infection rate was obviously increased after OHPV from 0.3% to 2.1%. Our study demonstrates that the prevalence of HPV16/18 infection dramatically decreased and the profile of type-specific HPV infection was changed after OHPV.

    DOI: 10.3390/vaccines8030425

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  • Japan's Ongoing Crisis on HPV Vaccination. 査読 国際誌

    Masayuki Sekine, Risa Kudo, Manako Yamaguchi, Sharon J B Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

    Vaccines   8 ( 3 )   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    : The Japanese government suspended proactive recommendations for the HPV vaccine in June 2013. The suspension is now in its seventh year, despite all the data pointing to the safety of the HPV vaccine. We reported a high vaccine effectiveness in the group of women vaccinated before their first intercourse (93.9%). The prevalence of cross-protected types of HPV 31/45/52 was also lower in the vaccinated group, and the vaccine effectiveness was 67.7%. Furthermore, prevalence of HPV16, 31 and 52 infection rates in the vaccinated group were obviously lower than that in the unvaccinated group, and no one had HPV18 or 45 infection in the vaccinated group. The addition of a cross-protective effect toward HPV types 31/45/52 to HPV types 16/18, which is the direct target of the bivalent HPV vaccine, may possibly prevent around 82% of invasive cervical cancer cases in Japan. With regard to the preventive effect of histological abnormalities, we also reported significant reduction in incidence of cervical intraepithelial neoplasia (CIN)3 or worse. Thus, the efficacy of the vaccine has been demonstrated for precancerous disease, and the diverse symptoms after HPV vaccination are likely functional somatic. For the future of Japanese girls, there is a need to resume the proactive recommendation of HPV vaccination and for immediate action to be taken by the Japanese government.

    DOI: 10.3390/vaccines8030362

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  • 卵巣卵黄嚢腫瘍に対する妊孕性温存治療後、残存卵巣に発症した成熟嚢胞性奇形腫摘出術前に卵子凍結を施行した1例(A case of mature teratoma in the residual ovary after fertility-sparing therapy for ovarian yolk sac tumor managed with oocyte cryopreservation followed by cystectomy)

    茅原 誠, 安達 聡介, 鈴木 久美子, 石黒 竜也, 西川 伸道, 関根 正幸, 荒井 勇樹, 木下 義晶, 榎本 隆之

    Journal of Mammalian Ova Research   37 ( 1 )   43 - 49   2020年7月

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    記述言語:英語   出版者・発行元:(一社)日本卵子学会  

    症例は17歳.10歳時に卵黄嚢腫瘍IIICを発症し,右付属器切除と術後化学療法が施行された.初回治療から7年後,残存左卵巣に16cm大の成熟嚢胞性奇形腫が疑われた.正常卵巣部位は画像診断で非常に小さく明らかでなかった.卵巣腫瘍摘出術を施行した場合,医原性卵巣機能不全の発症を危惧したため,腫瘍摘出前に卵子凍結保存を施行する方針とした.性交歴がない事,経腔・経腹採卵では腫瘍内容液漏出の可能性があったため,予定開腹手術時に同期して採卵する方針とした.黄体期ランダムスタートとして,排卵誘発を施行し,hCGとGnRHアゴニスト併用によるダブルトリガー後に採卵した.計10個のMII卵を回収し,同日凍結保存した.卵巣腫瘍が非常に大きい場合,開腹卵巣腫瘍直視下で超音波ガイド下に採卵することは安全かつ有効である.(著者抄録)

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  • 目標・方略・評価を基盤とした卒後・専門教育のあり方〜現状とあるべき姿〜 産婦人科領域における臨床研修医教育、専攻医教育、サブスペシャリティ教育における現状と問題点

    磯部 真倫, 錦織 宏, 榎本 隆之

    医学教育   51 ( Suppl. )   42 - 42   2020年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • Cancers associated with extraovarian endometriosis at less common/rare sites: A nationwide survey in Japan. 査読 国際誌

    Masaki Mandai, Yutaka Osuga, Tetsuya Hirata, Takayuki Enomoto, Hidekatsu Nakai, Ritsuo Honda, Fuminori Taniguchi, Hidetaka Katabuchi

    The journal of obstetrics and gynaecology research   46 ( 6 )   917 - 923   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: Endometriosis mostly affects the ovary but can also be present outside of the ovary including the pelvic peritoneum, intestine, urinary tract and lung. In case of ovarian endometriotic cyst, an increased risk of ovarian cancer, especially of clear cell and endometrioid histology, has been reported. However, because of the rarity, cancer occurrence from endometriosis at less common sites/rare sites is poorly understood. METHODS: We conducted a nationwide survey on the less common/rare site endometriosis in 3539 authorized facilities in Japan. We requested to complete a case report form for each case, including information on the history of endometriosis, treatment for endometriosis, type of surgery, involved site(s) of cancer and endometriosis, histology of cancer, chemotherapy and outcome. RESULTS: Out of 1397 confirmed cases of less common/rare site endometriosis, 11 cases of rare site endometriosis-associated cancer (RSEAC) were reported: seven of them were associated with intestinal endometriosis, three were associated with urinary tract endometriosis and one was associated with umbilical endometriosis. Interestingly, the histology was endometrioid in seven (64%) cases, and serous, seromucinous borderline, clear cell and mucinous in one case each (10%), differing from the case of ovarian endometriosis-associated cancer, in which clear cell carcinoma are more common. CONCLUSION: Our nationwide survey on RSEAC has revealed that: (i) the incidence of malignant transformation may be lower than ovarian endometriosis, (ii) malignant transformation from endometriosis outside the abdominal cavity may be extremely rare and (iii) the histology of RSEAC is predominantly endometrioid type, suggesting an association of a hormonal effect.

    DOI: 10.1111/jog.14244

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  • 【婦人科がん臨床研究のトレンドを知る】婦人科悪性腫瘍研究機構(JGOG) 卵巣がん

    島田 宗昭, 梶山 広明, 榎本 隆之

    産科と婦人科   87 ( 6 )   669 - 674   2020年6月

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    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    婦人科悪性腫瘍研究機構(JGOG)は、Gynecologic Cancer Intergroup(GCIG)をはじめとする国際共同試験に参画し、データ管理、臨床試験のコーディネートなどのインフラ整備を進め、国際共同第III相試験も主導し、国際的評価に耐え得る臨床研究の成果を報告してきた。がんゲノム医療が臨床実装され、生体試料を用いたゲノム解析と臨床情報との統合解析の重要性を勘案し、JGOGは東北メディカル・メガバンク機構(ToMMo)との連携を進め、高い品質管理のもと臨床研究に対応する生体試料を集積する仕組みを確立した。卵巣がん委員会では、新たに設置されたtranslational research(TR)委員会と協働し、より精密な個別化医療の実装を目指すTR研究の遂行を目指す体制を強化し、TR研究を開始した。さらに、これまでに主導した国際共同臨床試験のデータを用いた深層学習に基づき、機械学習を用いた予測医療(予後予測、治療効果予測)の実現を目指す新たな試みも開始した。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00525&link_issn=&doc_id=20200603040008&doc_link_id=%2Fae4sanke%2F2020%2F008706%2F009%2F0669b0674%26dl%3D3&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae4sanke%2F2020%2F008706%2F009%2F0669b0674%26dl%3D3&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_4.gif

  • 【パンデミック下の医学教育-現在進行形の実践報告-】ファカルティ・ディベロップメント Zoomによる教育事例検討会 オンラインFaculty Development

    磯部 真倫, 榎本 隆之, 錦織 宏

    医学教育   51 ( 3 )   338 - 340   2020年6月

  • 【内分泌外科領域のがんゲノム医療・precision medicine】婦人科癌のゲノム医療

    関根 正幸, 西野 幸治, 榎本 隆之

    日本内分泌外科学会雑誌   37 ( 2 )   126 - 130   2020年6月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌外科学会  

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  • Proposal of a Two-Tier System in Grouping Adenocarcinoma of the Uterine Cervix. 国際誌

    Hiroko Machida, Koji Matsuo, Shinya Matsuzaki, Wataru Yamagami, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Mikio Mikami

    Cancers   12 ( 5 )   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    (1) Background: This study examined the use of a two-tier system in grouping cervical adenocarcinoma for survival discrimination. (2) Methods: A nationwide retrospective observational cohort study was conducted using the Japan Society of Gynecologic Oncology tumor registry database from 2001 to 2015 (n = 86,754). Adenocarcinoma subtypes were grouped as type 1 (endocervical usual type and endometrioid) or type 2 (serous, clear, mucinous, and not otherwise specified), based on their relative survival compared with that of squamous tumors. (3) Results: The majority of the adenocarcinoma cases were type 1 (n = 10,121) versus type 2 tumors (n = 5157). Type 2 tumors were more likely to be old and have stage IV disease than those with squamous tumors. The number of type 2 tumors increased from 2001 to 2014 (106.1% relative increase, p < 0.001). Type 2 tumors had disproportionally poorer survival compared to other types (5-year survival rates: 68.9% for type 2, 75.4% for type 1, and 78.0% for squamous; p < 0.001). On multivariate analysis, type 2 tumors remained an independent prognostic factor associated with decreased survival compared with squamous (adjusted hazard ratio 2.00, 95% CI 1.84-2.15, p < 0.001). (4) Conclusion: The survival of cervical adenocarcinoma varies largely across the histological subtypes, and the proposed two-tier grouping may be useful for survival discrimination.

    DOI: 10.3390/cancers12051251

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  • 妊娠中の広汎子宮頸部摘出術

    西川 伸道, 石黒 竜也, 吉原 弘佑, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   38 ( 2 )   151 - 154   2020年4月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary. 査読 国際誌

    Ryo Tamura, Kosuke Yoshihara, Hirofumi Nakaoka, Nozomi Yachida, Manako Yamaguchi, Kazuaki Suda, Tatsuya Ishiguro, Koji Nishino, Hiroshi Ichikawa, Keiichi Homma, Akira Kikuchi, Yutaka Ueda, Yuji Takei, Hiroyuki Fujiwara, Teiichi Motoyama, Shujiro Okuda, Toshifumi Wakai, Ituro Inoue, Takayuki Enomoto

    Oncogene   39 ( 17 )   3541 - 3554   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Molecular characteristics of carcinoma arising from mature cystic teratoma of the ovary (MCT) remain unclear due to its rarity. We analyzed RNA-sequencing data of 2322 pan-cancer [1378 squamous cell carcinomas (SCC), 6 adenosquamous carcinomas (ASC), and 938 adenocarcinomas (AC)] including six carcinomas arising from MCT (four SCCs, one ASC, and one AC). Hierarchical clustering and principal component analysis showed that gene expression profiles of carcinomas arising from MCT were different between each histological type and that gene expression profiles of SCCs arising MCT (MCT-SCCs) was apparently similar to those of lung SCCs. By epidermis-associated pathways activity based on gene set enrichment analysis, 1030 SCCs were divided into two groups: epidermis-signature high (head and neck, esophagus, and skin) and low (cervix, lung, and MCT). In addition to pan-SCC transcriptome analysis, cytokeratin profiling based on immunohistochemistry in the independent samples of 21 MCT-SCCs clarified that MCT-SCC dominantly expressed CK18, suggesting the origin of MCT-SCC was columnar epithelium. Subsequently, we investigated differentially expressed genes in MCT-SCCs compared with different SCCs and identified XCL1 was specifically overexpressed in MCT-SCCs. Through immunohistochemistry analysis, we identified XCL1 expression on tumor cells in 13/24 (54%) of MCT-SCCs but not in MCTs. XCL1 expression was also significantly associated with the number of tumor-infiltrating CD8-positive T cells and PD-L1 expression on tumor cells. XCL1 produced by tumor cells may induce PD1/PD-L1 interaction and dysfunction of CD8-positive T cells in tumor microenvironment. XCL1 expression may be a novel biomarker for malignant transformation of MCT into SCC and a biomarker candidate for therapeutic response to an anti-PD1/PD-L1 therapy.

    DOI: 10.1038/s41388-020-1237-0

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  • 初期子宮頸癌における脈管侵襲陽性例の取り扱いとその予後 本邦における子宮頸部円錐切除術14,832例の検討より

    橋本 奈美子, 上浦 祥司, 池田 仁惠, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 片渕 秀隆, 三上 幹男

    日本産科婦人科学会雑誌   72 ( 臨増 )   S - 298   2020年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 臨床的FIGO IVb期子宮体がんに対する術前化学療法後腫瘍切除術に関するFeasibility Study

    中西 透, 渡部 洋, 青木 大輔, 牛嶋 公生, 高野 政志, 榎本 隆之, 杉山 徹, 八重樫 伸生, 竹原 和宏, 齋藤 俊章

    日本産科婦人科学会雑誌   72 ( 臨増 )   S - 448   2020年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 子宮頸癌進行期分類FIGO2018の検証 IB3期(FIGO2018)の臨床病理学的検討

    萩原 達也, 島田 宗昭, 辻 圭太, 徳永 英樹, 菊池 朗, 齋藤 豪, 藤堂 幸治, 三上 幹男, 榎本 隆之, 八重樫 伸生

    日本産科婦人科学会雑誌   72 ( 臨増 )   S - 315   2020年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 上皮性卵巣悪性ならびに境界悪性腫瘍に対する妊孕性温存手術の安全性と妊娠予後調査 日本産科婦人科学会婦人科腫瘍委員会報告

    久慈 志保, 鈴木 直, 三上 幹男, 吉岡 範人, 梶山 広明, 佐藤 豊実, 生水 真紀夫, 八重樫 伸生, 榎本 隆之, 日本産科婦人科学会婦人科腫瘍委員会

    日本産科婦人科学会雑誌   72 ( 臨増 )   S - 298   2020年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • プラチナ製剤感受性再発卵巣癌に対するオラパリブ投与に関する検討

    鈴木 美保, 西川 伸道, 田村 亮, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 山口 雅幸, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   72 ( 臨増 )   S - 309   2020年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 【やさしくわかる 産科婦人科検査マスターブック】(第2章)婦人科腫瘍分野 BRCA1/BRCA2遺伝子

    関根 正幸, 西野 幸治, 榎本 隆之

    産科と婦人科   87 ( Suppl. )   163 - 167   2020年3月

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    記述言語:日本語   出版者・発行元:(株)診断と治療社  

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  • Vaccine Hesitancy HPVワクチン 日本の今と未来

    山口 真奈子, 関根 正幸, 工藤 梨沙, 安達 聡介, 上田 豊, 宮城 悦子, 原 めぐみ, シャロン・ハンリー, 榎本 隆之

    日本小児科学会雑誌   124 ( 2 )   181 - 181   2020年2月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • A National Survey of Umbilical Endometriosis in Japan. 査読 国際誌

    Tetsuya Hirata, Kaori Koga, Mari Kitade, Shinya Fukuda, Kazuaki Neriishi, Fuminori Taniguchi, Ritsuo Honda, Naoko Takazawa, Toshiaki Tanaka, Masatoshi Kurihara, Jun Nakajima, Shigeo Horie, Hidekatsu Nakai, Takayuki Enomoto, Masaki Mandai, Hisashi Narahara, Jo Kitawaki, Tasuku Harada, Hidetaka Katabuchi, Kotaro Yoshimura, Yutaka Osuga

    Journal of minimally invasive gynecology   27 ( 1 )   80 - 87   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    STUDY OBJECTIVE: To identify the clinical presentation, diagnostic evaluation, operative or medical management, and postoperative recurrence of umbilical endometriosis. DESIGN: A retrospective national survey. SETTING: Obstetrics and Gynecology and Plastic Surgery Departments at a teaching hospital in Japan. PATIENTS: Patients with umbilical endometriosis or malignant transformation. INTERVENTIONS: A national survey was conducted to identify and evaluate cases of umbilical endometriosis or malignant transformation documented between 2006 and 2016. MEASUREMENTS AND MAIN RESULTS: The following were evaluated for each patient: age at diagnosis, body mass index, medical history, presence of extragenital endometriosis, surgical history, symptoms, imaging modalities, surgical therapy, hormonal therapy, follow-up period, postoperative recurrence, and time to recurrence. Ninety-six patients were identified with pathologically diagnosed benign umbilical endometriosis. The patients frequently had swelling (86.5%), pain (81.3%), or bleeding (44.8%) in the umbilicus. Sensitivity was 87.1% for physical examination, 76.5% for transabdominal ultrasonography, 75.6% for computed tomography, and 81.8% for magnetic resonance imaging. The cumulative recurrence rate was 1.34% at 6 months, 6.35% at 12 months, and 6.35% at 60 months after surgery. Importantly, there was no recurrence after wide resection including of the peritoneum (0 of 37 cases). The efficacy of dienogest (an oral progestin), gonadotropin-releasing hormone agonists, and oral contraceptives was 91.7%, 81.8%, and 57.1%, respectively. Finally, 2 cases of malignant transformation were identified. CONCLUSION: There was a low recurrence rate following surgery, and hormonal treatment is an option, although the current findings suggest surgical therapy as the first choice of treatment for umbilical endometriosis.

    DOI: 10.1016/j.jmig.2019.02.021

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  • 新潟県における周産期メンタルヘルス研究の取り組み

    茂木 崇治, 福井 直樹, 藤田 真貴, 須貝 拓朗, 江川 純, 橋尻 洸陽, 坪谷 隆介, 三留 節子, 荒木 理恵, 生野 寿史, 山口 雅幸, 西島 浩二, 高桑 好一, 榎本 隆之, 染矢 俊幸

    新潟県医師会報   ( 838 )   7 - 8   2020年1月

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    記述言語:日本語   出版者・発行元:新潟県医師会  

    妊産婦自身の被養育体験、パートナーとの関係性、対人コミュニケーション能力などの妊産婦自身の発達特性、周産期の不安や抑うつ、アタッチメントやボンディング、以上の項目の相互の関連について検討した。さらに、本研究で同定された関連性に対して、産科学的情報も加味しながら産婦人科および小児科と連携し、精神医学的立場から妊産婦を対象とした適切な介入システムを構築した。妊娠初期(妊娠12週〜15週前後)、後期(妊娠30〜34週)、産後(1ヵ月)の妊産婦を対象にアンケート調査を実施する。周産期のメンタルヘルスや子どもとのアタッチメント形成を予測する因子を同定することで、精神科医の早期からの適切な介入が可能となり、妊産婦の自殺予防に大きく貢献可能であると同時に、子どもとの良好なアタッチメント形成に寄与できる点において、大きな意義があると考えられた。

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  • Depression, Anxiety and Primiparity are Negatively Associated with Mother-Infant Bonding in Japanese Mothers. 国際誌

    Takaharu Motegi, Yuichiro Watanabe, Naoki Fukui, Maki Ogawa, Koyo Hashijiri, Ryusuke Tsuboya, Takuro Sugai, Jun Egawa, Rie Araki, Kazufumi Haino, Masayuki Yamaguchi, Koji Nishijima, Takayuki Enomoto, Toshiyuki Someya

    Neuropsychiatric disease and treatment   16   3117 - 3122   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Purpose: Postpartum depression is a well-known risk factor, and postpartum anxiety and parity are potential risk factors, for mother-infant bonding disorder. However, few studies have focused on the relationships among these factors and mother-infant bonding. This cross-sectional study explored the associations between depression, anxiety and parity, and mother-infant bonding. Materials and Methods: Japanese mothers, both primiparas and multiparas, completed the Mother-to-Infant Bonding Scale (MIBS) and the Hospital Anxiety and Depression Scale (HADS) one month after childbirth. We performed a stepwise multiple regression analysis with the forward selection method to assess the effects of HADS anxiety and depression scores and parity as independent variables on mother-infant bonding as the dependent variable. Results: A total of 2379 Japanese mothers (1116 primiparas and 1263 multiparas) took part in the study. MIBS score (2.89 ± 2.68 vs 1.60 ± 2.11; p < 0.0001) was significantly higher in primiparas than in multiparas. HADS anxiety (6.55 ± 4.06 vs 4.63 ± 3.41; p < 0.0001) and depression (6.56 ± 3.43 vs 5.98 ± 3.20; p < 0.0001) scores were also significantly higher in primiparas than in multiparas. A stepwise multiple regression analysis with the forward selection method revealed that HADS depression and anxiety scores and parity were significantly associated with MIBS score (p = 0.003, 0.015 and 0.023). Conclusion: Depression, anxiety and primiparity were negatively associated with mother-infant bonding one month after childbirth.

    DOI: 10.2147/NDT.S287036

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  • Value and limitation of conization as a diagnostic procedure for cervical neoplasm. 査読 国際誌

    Yamamoto R, Sekiyama K, Higuchi T, Ikeda M, Mikami M, Kobayashi Y, Nagase S, Yokoyama M, Enomoto T, Katabuchi H

    The journal of obstetrics and gynaecology research   45 ( 12 )   2419 - 2424   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jog.14118

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  • 婦人科悪性疾患に対する消化器外科介入症例の検討

    亀山 仁史, 島田 能史, 阿部 馨, 小柳 英人, 中野 麻恵, 中野 雅人, 市川 寛, 羽入 隆晃, 滝沢 一泰, 永橋 昌幸, 坂田 純, 小林 隆, 西川 伸道, 榎本 隆之, 若井 俊文

    癌と化学療法   46 ( 13 )   2176 - 2178   2019年12月

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    記述言語:日本語   出版者・発行元:(株)癌と化学療法社  

    背景:婦人科悪性腫瘍に対して、婦人科医と消化器外科医による合同手術がしばしば行われているが、その術後成績については明らかでない。目的:婦人科悪性疾患手術時に消化器外科医が介入した症例について、術式、合併症、予後などの術後成績を明らかにすることを目的とした。対象と方法:2010年1月〜2014年12月までの5年間の73例を対象とした。疾患、術式、術後合併症、ストーマの有無、入院期間、予後などを検討した。結果:年齢中央値(範囲)は60(15〜78)歳、73例全例が女性であった。緊急手術が8例(11.0%)含まれていた。疾患は、卵巣癌が56例(76.7%)と最も多く、Stageの内訳はStage I/II/III/IV/再発:4/4/20/11/17例であった。25例(34.2%)で腸管切除吻合が行われていた。また、22例(30.1%)でストーマが造設されていたが、本検討ではストーマ閉鎖を行えた症例はなかった。手術時間(婦人科原発巣手術時間も含む)中央値(範囲)は252(37〜690)分であり、出血量は1,190(0〜11,210)mLであった。術後の合併症(Clavien-Dindo II以上)として、イレウス6例(8.2%)、腹骨盤内膿瘍4例(5.5%)、縫合不全2例(2.7%)などがみられた。Grade III以上の合併症としてはイレウス、縫合不全、腹水、膵液瘻がそれぞれ1例ずつ認められた。卵巣癌全症例の術後生存期間中央値は1,399日であった。結論:婦人科との合同手術のなかで、消化器外科医は進行卵巣癌の手術に携わることが多い。ストーマを造設した症例のストーマ閉鎖は困難であるが、消化管切除を含む腫瘍切除によって予後の延長に寄与することが期待される。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00296&link_issn=&doc_id=20200117590089&doc_link_id=%2Fab8gtkrc%2F2019%2F004613%2F089%2F2176-2178%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2019%2F004613%2F089%2F2176-2178%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients. 査読 国際誌

    Kentaro Sugino, Ryo Tamura, Hirofumi Nakaoka, Nozomi Yachida, Manako Yamaguchi, Yutaro Mori, Kaoru Yamawaki, Kazuaki Suda, Tatsuya Ishiguro, Sosuke Adachi, Masanori Isobe, Masayuki Yamaguchi, Katsunori Kashima, Teiichi Motoyama, Ituro Inoue, Kosuke Yoshihara, Takayuki Enomoto

    Scientific reports   9 ( 1 )   17808 - 17808   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We explored the frequency of germline and somatic mutations in homologous recombination (HR)-associated genes in major histological types of ovarian cancer. We performed targeted sequencing to assess germline and somatic mutations of 16 HR-associated genes and 4 mismatch repair (MMR) genes among 207 ovarian cancer patients (50 high-grade serous carcinomas (HGSC), 99 clear cell carcinomas (CCC), 39 endometrioid carcinomas (EC), 13 mucinous carcinomas (MC), and 6 low-grade serous carcinomas (LGSC)). Germline or somatic mutations of HR-associated genes were detected in 44% of HGSC, 28% of CCC, 23% of EC, 16% of MC, and 17% of LGSC patients. The profile of HR-associated gene mutations was remarkably different among each histological type. Germline BRCA1/2 mutations were frequently detected in HGSC and were rarely observed in CCC, EC, and MC patients. ATM somatic mutation was more frequently detected in CCC (9%) and EC patients (18%) than in HGSC patients (4%). There was a positive correlation between MMR gene mutations and HR-associated gene mutations (p = 0.0072). Our findings might be useful in selection of ovarian cancer patients that should be treated with PARP inhibitors.

    DOI: 10.1038/s41598-019-54116-y

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  • Fertility-sparing trachelectomy for early-stage cervical cancer: A proposal of an ideal candidate. 査読 国際誌

    Machida H, Iwata T, Okugawa K, Matsuo K, Saito T, Tanaka K, Morishige K, Kobayashi H, Yoshino K, Tokunaga H, Ikeda T, Shozu M, Yaegashi N, Enomoto T, Mikami M

    Gynecologic oncology   156 ( 2 )   341 - 348   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ygyno.2019.11.021

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  • Neoadjuvant chemotherapy for epithelial ovarian cancer in Japan: a JSGO-JSOG joint study. 査読 国際誌

    Machida H, Matsuo K, Enomoto T, Mikami M

    Journal of gynecologic oncology   30 ( 6 )   e113   2019年11月

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  • Intraoperative Capsule Rupture, Postoperative Chemotherapy, and Survival of Women With Stage I Epithelial Ovarian Cancer. 査読 国際誌

    Matsuo K, Machida H, Yamagami W, Ebina Y, Kobayashi Y, Tabata T, Kaneuchi M, Nagase S, Enomoto T, Mikami M

    Obstetrics and gynecology   134 ( 5 )   1017 - 1026   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/AOG.0000000000003507

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  • The 61st Annual Meeting of the Japanese Society for Gynecologic Oncology (JSGO). 査読

    Yoshihara K, Sekine M, Nishino K, Enomoto T

    Journal of gynecologic oncology   30 ( 6 )   e114   2019年11月

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  • Changes in the Clinicopathological Demographics of Vulvar Cancer in Japan: Increasing Oldest-Old, Stage Shifting, and Decreasing Cohort-Level Survival <sup>†</sup>. 査読

    Nishio S, Matsuo K, Shibata T, Yamaguchi S, Kanao H, Takehara K, Kado N, Tozawa A, Tokunaga H, Matsunaga T, Kato H, Horie K, Kikuchi A, Enomoto T, Mikami M

    Journal of clinical medicine   8 ( 12 )   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/jcm8122081

    Web of Science

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  • 当院でのプラチナ製剤感受性再発卵巣癌に対するオラパリブ投与に関する検討

    西川 伸道, 堀内 綾乃, 春谷 千智, 明石 英彦, 鈴木 美保, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   114 ( 1 )   32 - 32   2019年11月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 子宮脱に対する腟閉鎖術の術前頸部細胞診にてNILMであったにもかかわらず1年半後に子宮頸部扁平上皮癌IIB期と診断された一例

    小林 暁子, 西野 幸治, 小木 幹奈, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟県臨床細胞学会会報   ( 34 )   20 - 20   2019年11月

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    記述言語:日本語   出版者・発行元:新潟県臨床細胞学会  

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  • ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer. 査読 国際誌

    Mori Y, Yamawaki K, Ishiguro T, Yoshihara K, Ueda H, Sato A, Ohata H, Yoshida Y, Minamino T, Okamoto K, Enomoto T

    Stem cell reports   13 ( 4 )   730 - 746   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.stemcr.2019.08.015

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  • Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium. 査読 国際誌

    Suda K, Nakaoka H, Yoshihara K, Ishiguro T, Adachi S, Kase H, Motoyama T, Inoue I, Enomoto T

    Human reproduction (Oxford, England)   34 ( 10 )   1899 - 1905   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/humrep/dez155

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  • 日本人女性における性的活動性とHPV感染、子宮頸部組織診異常との関係

    山口 真奈子, 関根 正幸, 工藤 梨沙, 安達 聡介, 上田 豊, 宮城 悦子, 原 めぐみ, Hanley Sharon J.B., 榎本 隆之

    日本癌治療学会学術集会抄録集   57回   O1 - 1   2019年10月

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    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

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  • 急性腹症を契機に診断が修正された子宮・尿路奇形の1症例

    工藤 梨沙, 小林 暁子, 磯部 真倫, 春谷 千智, 明石 英彦, 鈴木 美穂, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本女性医学学会雑誌   27 ( 1 )   250 - 250   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本女性医学学会  

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  • Biology of the vernix caseosa: A review. 査読 国際誌

    Nishijima K, Yoneda M, Hirai T, Takakuwa K, Enomoto T

    The journal of obstetrics and gynaecology research   45 ( 11 )   2145 - 2149   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jog.14103

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  • HPVワクチンの積極的勧奨一時中止継続によって増加する将来の子宮頸がんの罹患・死亡数予測(Estimated increases of cervical cancer incidence and mortality due to suspension of recommendation of HPV vaccine) 査読

    八木 麻未, 上田 豊, 中川 慧, 宮城 悦子, 榎本 隆之, 中山 富雄, 木村 正

    日本癌学会総会記事   78回   P - 2210   2019年9月

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    記述言語:英語   出版者・発行元:日本癌学会  

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  • 子宮頸癌進行期分類FIGO2018の検証 IB3期(FIGO2018)の臨床病理学的検討

    萩原 達也, 島田 宗昭, 辻 圭太, 徳永 英樹, 児玉 省二, 齋藤 豪, 藤堂 幸治, 榎本 隆之, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   49 - 49   2019年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • HPVワクチンの積極的勧奨一時中止継続によって増加する将来の子宮頸がんの罹患・死亡数予測(Estimated increases of cervical cancer incidence and mortality due to suspension of recommendation of HPV vaccine)

    八木 麻未, 上田 豊, 中川 慧, 宮城 悦子, 榎本 隆之, 中山 富雄, 木村 正

    日本癌学会総会記事   78回   P - 2210   2019年9月

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    記述言語:英語   出版者・発行元:(一社)日本癌学会  

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  • Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer. 査読

    Matsuo K, Cripe JC, Kurnit KC, Kaneda M, Garneau AS, Glaser GE, Nizam A, Schillinger RM, Kuznicki ML, Yabuno A, Yanai S, Garofalo DM, Suzuki J, St Laurent JD, Yen TT, Liu AY, Shida M, Kakuda M, Oishi T, Nishio S, Marcus JZ, Adachi S, Kurokawa T, Ross MS, Horowitz MP, Johnson MS, Kim MK, Melamed A, Machado KK, Yoshihara K, Yoshida Y, Enomoto T, Ushijima K, Satoh S, Ueda Y, Mikami M, Rimel BJ, Stone RL, Growdon WB, Okamoto A, Guntupalli SR, Hasegawa K, Shahzad MMK, Im DD, Frimer M, Gostout BS, Ueland FR, Nagao S, Soliman PT, Thaker PH, Wright JD, Roman LD

    Gynecologic oncology   155 ( 1 )   39 - 50   2019年8月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ygyno.2019.08.007

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  • Identifying the factor structure of the Mother-to-Infant Bonding Scale for post-partum women and examining its consistency during pregnancy. 査読 国際誌

    Motegi T, Fukui N, Hashijiri K, Tsuboya R, Sugai T, Egawa J, Mitome S, Araki R, Haino K, Yamaguchi M, Takakuwa K, Enomoto T, Someya T

    Psychiatry and clinical neurosciences   73 ( 10 )   661 - 662   2019年8月

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    記述言語:英語  

    DOI: 10.1111/pcn.12920

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  • 電解質溶液内経頸管的切除術Trans Cervical Resection in saline, TCRisの使用経験

    鈴木 美保, 小林 暁子, 春谷 千智, 明石 英彦, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   200 - 200   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 子宮筋腫茎捻転における腹腔鏡下手術の有用性

    石黒 竜也, 茅原 誠, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   246 - 246   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 子宮体癌1A期と子宮頸癌3A期が合併した1例

    工藤 梨沙, 磯部 真倫, 春谷 千智, 明石 英彦, 鈴木 美穂, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   294 - 294   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 内視鏡手術の地域間格差とその対策 NDBオープンデータから見た婦人科腹腔鏡手術の地域間格差とその解決法

    磯部 真倫, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   27 - 27   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 腹腔鏡下仙骨固定術における子宮腟上部切断および残存頸部縫合の方法とそれによる感染予防に関する検討 感染例から学ぶ

    小林 暁子, 磯部 真倫, 明石 英彦, 石黒 竜也, 安達 聡介, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   115 - 115   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 当院における腹腔鏡下仙骨腟固定術の手術成績および排尿

    明石 英彦, 小林 暁子, 安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   114 - 114   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 帝王切開既往症例における膀胱挙上、癒着に対する腹腔鏡下子宮全摘術時の膀胱剥離の定型化とその効果

    堀内 綾乃, 小林 暁子, 春谷 千智, 明石 英彦, 鈴木 美保, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   214 - 214   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 完全直腸脱を伴う4度骨盤臓器脱に対して腹腔鏡下直腸固定術と同時に仙骨腟固定術を行った2症例

    春谷 千智, 小林 暁子, 明石 英彦, 鈴木 美保, 工藤 梨沙, 茅原 誠, 石黒 竜也, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之, 中野 雅人

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   116 - 116   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • Cervical cancer screening rate differs by HPV vaccination status: An interim analysis. 査読 国際誌

    Mariko Taniguchi, Yutaka Ueda, Asami Yagi, Sayaka Ikeda, Masayuki Endo, Takuji Tomimatsu, Tomio Nakayama, Masayuki Sekine, Takayuki Enomoto, Tadashi Kimura

    Vaccine   37 ( 32 )   4424 - 4426   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The incidence of cervical cancer has been increasing, especially in younger generation, in Japan. The females born between 1994 and 1999, who achieved rates of HPV vaccination approaching 70%, have become the target of cervical cancer screening programs. Here, we have analyzed the cervical cancer screening rates among the vaccinated and unvaccinated women. METHODS: The survey data for cervical cancer screening at age 20 in FY 2015 was derived from two cities, Toyonaka and Iwaki. RESULTS: Among 2,727 females, in Toyonaka and Iwaki, who were born in FY 1995 and targeted in FY 2015 at age 20 for cervical cancer screening, their HPV vaccination rate was 64.2% (1,753/2,727). The screening rate was 6.4% (112/1,753) in the vaccinated and 3.9% (38/974) in the unvaccinated. This difference was statistically significant (p < 0.01). CONCLUSIONS: We have demonstrated that HPV-vaccinated females tended to be effectively protected from future cervical cancer than the unvaccinated.

    DOI: 10.1016/j.vaccine.2019.06.064

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  • The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9). 査読

    Nonaka T, Takahashi M, Nonaka C, Enomoto T, Takakuwa K

    Reproductive medicine and biology   18 ( 3 )   296 - 301   2019年7月

  • The first Japanese nationwide multicenter study of <i>BRCA</i> mutation testing in ovarian cancer: CHARacterizing the cross-sectionaL approach to Ovarian cancer geneTic TEsting of <i>BRCA</i> (CHARLOTTE). 査読 国際誌

    Enomoto T, Aoki D, Hattori K, Jinushi M, Kigawa J, Takeshima N, Tsuda H, Watanabe Y, Yoshihara K, Sugiyama T

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society   29 ( 6 )   1043 - 1049   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/ijgc-2019-000384

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  • Googleフォームを用いた双方向性講義の取り組み

    磯部 真倫, 榎本 隆之

    医学教育   50 ( Suppl. )   210 - 210   2019年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • 子宮頸部円錐切除術後の追加治療例に関する検討(JSOG婦人科腫瘍委員会)

    長嶋 武雄, 寺内 文敏, 佐川 泰一, 西 洋孝, 池田 仁惠, 三上 幹男, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 片渕 秀隆

    日本婦人科腫瘍学会雑誌   37 ( 3 )   444 - 444   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 術前HPV診断と子宮頸部円錐切除術後診断、予後に関する検討 JSOG腫瘍委員会報告

    菊池 朗, 高橋 宏太朗, 吉田 邦彦, 横尾 朋和, 池田 仁惠, 三上 幹男, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 片渕 秀隆

    日本婦人科腫瘍学会雑誌   37 ( 3 )   436 - 436   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • わが国における子宮頸部円錐切除術の実態 日本産科婦人科学会腫瘍委員会「子宮頸部円錐切除術の実態調査に関する小委員会」報告

    池田 仁惠, 三上 幹男, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 片渕 秀隆

    日本婦人科腫瘍学会雑誌   37 ( 3 )   407 - 407   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • Precision medicineクリニカルシークエンスの現状と課題 HBOC診療の連携確立に向けて 新潟県の取り組み

    西野 幸治, 山口 雅幸, 安達 聡介, 吉原 弘祐, 関根 正幸, 榎本 隆之, 須田 一暁, 五十嵐 真由子, 土田 純子, 永橋 昌幸, 田澤 立之, 栗山 洋子, 藤田 沙織里, 小山 諭, 菊池 朗, 佐藤 信昭, 金子 耕司, 田村 恵美子, 三冨 亜希, 後藤 清恵

    日本婦人科腫瘍学会雑誌   37 ( 3 )   328 - 328   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 稀少部位子宮内膜症の癌化に関する全国調査

    万代 昌紀, 大須賀 穣, 平田 哲也, 谷口 文紀, 榎本 隆之, 中井 英勝, 本田 律生, 片渕 秀隆

    日本婦人科腫瘍学会雑誌   37 ( 3 )   412 - 412   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 大学生は子宮頸がん予防をどう捉えているか? 医学部新入生を対象とした意識と知識に関する調査

    助川 明子, 鈴木 幸雄, 榎本 隆之, 関根 正幸, 上田 豊, 宮城 悦子

    日本婦人科腫瘍学会雑誌   37 ( 3 )   459 - 459   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 当院でのプラチナ製剤感受性再発卵巣癌に対するオラパリブ投与に関する検討

    堀内 綾乃, 西川 伸道, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   37 ( 3 )   546 - 546   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 子宮原発Perivascular epithelioid cell Tumor、PEComaの2例

    日向 妙子, 関根 正幸, 西川 伸道, 西野 幸治, 小林 暁子, 磯部 真倫, 吉原 弘祐, 安達 聡介, 石黒 竜也, 茅原 誠, 工藤 梨沙, 榎本 隆之, 本山 悌一

    日本婦人科腫瘍学会雑誌   37 ( 3 )   521 - 521   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 外科系教育の新時代 医師の現場で教育に必要とされるもの HowとWhyについて

    磯部 真倫, 榎本 隆之

    日本婦人科腫瘍学会雑誌   37 ( 3 )   334 - 334   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • The prognosis of patients with recurrent or persistent ovarian clear cell carcinoma: Results from a randomized phase III study (JGOG3017/GCIG). 査読

    Kondo Eiji, Tabata Tsutomu, Suzuki Nao, Aoki Daisuke, Tokuyama Osamu, Kato Kiyoko, Hamano Tetsutaro, Kotera Yoshio, Fujiwara Keiichi, Kimura Eizo, Terauchi Fumitoshi, Sumi Toshiyuki, Okamoto Aikou, Yaegashi Nobuo, Enomoto Takayuki, Sugiyama Toru

    JOURNAL OF CLINICAL ONCOLOGY   37 ( 15 )   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Evaluation of future cervical cancer risk in Japan, based on birth year. 査読 国際誌

    Asami Yagi, Yutaka Ueda, Sayaka Ikeda, Masayuki Sekine, Tomio Nakayama, Etsuko Miyagi, Takayuki Enomoto

    Vaccine   37 ( 22 )   2889 - 2891   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In 2013, following the Ministry of Health, Labor and Welfare (MHLW)'s announced suspension of its vaccine recommendation due to media reports of "adverse events", HPV vaccination dropped to almost 0%. Here, we analyzed, by birth year, the cumulative vaccinations for girls up to age 16 (maximum age for public subsidies) and the results of cervical cancer screening in Matsuyama City. The incidence of CIN3 or worse was 0.09% (7/7872) for these unvaccinated generation born between 1991 and 1993, and 0.00% (0/7389) for the vaccination generation born between 1994 and 1996. This study is the first to show the significant reduction in incidence of CIN3+depending on birth year in Japan. We must keep in mind that the unacceptable high risk for cervical cancer has already begun for an entire new generation of unvaccinated girls born in or after 2000. This data encourages a resumption of MHLW's recommendation for HPV vaccination.

    DOI: 10.1016/j.vaccine.2019.04.044

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  • Current knowledge of and attitudes toward human papillomavirus-related disease prevention among Japanese: A large-scale questionnaire study. 査読 国際誌

    Yukio Suzuki, Akiko Sukegawa, Aya Nishikawa, Kazumi Kubota, Yoko Motoki, Mikiko Asai-Sato, Yutaka Ueda, Masayuki Sekine, Takayuki Enomoto, Fumiki Hirahara, Takeharu Yamanaka, Etsuko Miyagi

    The journal of obstetrics and gynaecology research   45 ( 5 )   994 - 1005   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: The human papillomavirus (HPV) vaccination rate in Japan fell to nearly 0% following widespread coverage of possible adverse events. Developing a next approach to promote the effective prevention of HPV-related diseases including cervical cancer (CC) in Japan requires comprehensive understanding of knowledge and attitudes regarding CC prevention, HPV infection and HPV vaccination among the population including laypersons and medical professions in Japan. METHODS: A questionnaire survey was administered in a wide variety of settings in Japan. The questionnaire contained items on knowledge about CC, HPV infection and HPV vaccination; awareness of the HPV vaccine's effectiveness and associated adverse events; and attitudes toward the HPV vaccination for their daughters and for men/boys. RESULTS: Of 3033 targeted people, complete survey responses were received from 1182 men and 1602 women (total: 2784). The male laypersons' group had significantly lower knowledge than did the female laypersons' group (adjusted odds ratio, aOR = 3.86, P < 0.001). Compared with the male laypersons' group, the female laypersons' group tended to have less positive attitudes toward HPV vaccination for their daughters (aOR = 0.78, P = 0.006), but the female laypersons' group showed more positive attitudes toward vaccinating men/boys (aOR = 1.93, P < 0.001). CONCLUSION: The survey results indicated that men in Japan generally lacked knowledge and awareness of HPV-related diseases and their prevention. However, women had more negative attitudes toward HPV vaccination for their daughters than did men. Increasing male involvement in HPV prevention and changing women's perceptions of the HPV vaccine are essential steps to increase the HPV vaccination rate.

    DOI: 10.1111/jog.13929

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  • Clinical background and outcomes of risk-reducing salpingo-oophorectomy for hereditary breast and ovarian cancers in Japan. 査読

    Nomura H, Sekine M, Yokoyama S, Arai M, Enomoto T, Takeshima N, Nakamura S

    International journal of clinical oncology   24 ( 9 )   1105 - 1110   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10147-019-01456-4

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  • HPV vaccination in Japan: what is happening in Japan? 査読 国際誌

    Sayaka Ikeda, Yutaka Ueda, Asami Yagi, Shinya Matsuzaki, Eiji Kobayashi, Tadashi Kimura, Etsuko Miyagi, Masayuki Sekine, Takayuki Enomoto, Kazuya Kudoh

    Expert review of vaccines   18 ( 4 )   323 - 325   2019年4月

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  • 若年(AYA)がんと妊娠 妊娠とがん(悪性腫瘍合併妊娠の全国調査2014)

    近藤 英司, 田畑 務, 小林 良幸, 関根 正幸, 榎本 隆之, 池田 智明

    日本女性医学学会雑誌   26 ( 2 )   217 - 222   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本女性医学学会  

    本邦における悪性腫瘍合併妊娠は、妊娠年齢の高齢化と若年者の悪性腫瘍罹患率の上昇に伴い増加している。海外からの報告では1,000〜1,500妊婦に1人の割合でがんが罹患しているといわれており、乳がん、子宮頸がん、悪性リンパ腫、卵巣がん、白血病、消化管がん、悪性黒色腫、甲状腺がんの順とされている。de Haan J et al.(2018)。我々は2014年1月〜12月に、2008年からさらに本邦において妊娠年齢の高齢化と若年者の悪性腫瘍罹患率の上昇に伴い、悪性腫瘍合併妊娠(妊娠中〜産褥1年以内に診断もしくは治療された悪性腫瘍(上皮内癌を除く)が増加しているかの調査を再度施行した。本邦の周産期母子医療センターおよびがん診療拠点病院510施設のうち411施設から回答(回答率81%)を得て、124施設で悪性腫瘍合併妊娠があり、調査期間の総分娩数は207,750例、対象症例は189例(0.1%)であった。すなわち本邦でも1,000妊婦に1人の割合であり、海外の報告と同等であった。二次調査として、157例の解析可能なデータを集積し解析を行った。平均年齢は33歳、子宮頸がん(36%)、乳がん(24%)、卵巣がん(15%)、悪性リンパ腫(5.7%)、白血病(4.5%)、甲状腺がん(3.8%)、大腸がん(3.2%)、胃がん(2%)の順であった。一般的にどのがん腫においても妊娠時と非妊娠時の予後・生存率は同等とされている。今回の調査は海外の報告と同様に、悪性腫瘍合併妊娠の死亡例のほとんどは非婦人科腫瘍の進行症例であった。(1)妊娠初期の悪阻、下腹痛、体重減少と進行悪性腫瘍の自覚症状である嘔気、腹痛、体重減少等が類似していること(2)妊娠のために画像診断が避けられることから診断が遅れること(3)産婦人科医が非婦人科腫瘍の診断に習熟していないことが非婦人科腫瘍の診断が遅れ進行してから発見される症例がある理由の可能性が示唆された。(著者抄録)

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  • 【ご存じですか? 産婦人科領域で話題の薬物療法】卵巣がんに対するPARP阻害薬 オラパリブを中心に

    関根 正幸, 榎本 隆之

    産婦人科の実際   68 ( 4 )   391 - 396   2019年4月

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    記述言語:日本語   出版者・発行元:金原出版(株)  

    <文献概要>BRCA遺伝子などの機能喪失により引き起こされる「相同組換え修復異常」の臨床的サロゲートマーカーとしての「プラチナ感受性」再発卵巣癌を対象に,オラパリブ維持療法が臨床現場で広く使用され始めた。血管新生阻害薬あるいは免疫チェックポイント阻害薬との併用では,DNA損傷,低酸素環境,免疫チェックポイント関連分子の発現が関与し,その相乗効果を期待した多くの臨床試験が進行している。今後,BRCA変異を有する進行卵巣癌1次治療後の維持療法としての適応が追加承認される可能性が高いと考えられている。

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    その他リンク: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00535&link_issn=&doc_id=20190418160009&doc_link_id=10.18888%2Fsp.0000000819&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fsp.0000000819&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • Asian Society of Gynecologic Oncology International Workshop 2018. 査読

    Kong TW, Ryu HS, Kim SC, Enomoto T, Li J, Kim KH, Shim SH, Wang PH, Therasakvichya S, Kobayashi Y, Lee M, Shi T, Lee SW, Mikami M, Nagase S, Lim MC, Wang J, Wilailak S, Kim SW, Hong SH, Tan DS, Mandai M, Chang SJ, Huang RYJ, Ushijima K, Lee JY, Chen X, Ochiai K, Lee TS, Yang B, Kalam F, Lv Q, Ahmad MF, Yaznil MR, Modi KB, Manopunya M, Jeong DH, Lertkhachonsuk AA, Chung HH, Watari H, Jeon S

    Journal of gynecologic oncology   30 ( 2 )   e39   2019年3月

  • Treatment for patients with recurrent fetal losses positive for anti-cardiolipin beta2 glycoprotein I antibody using Sairei-to (Chai-ling-tang) and low-dose aspirin. 査読

    Nonaka T, Takahashi M, Nonaka C, Haino K, Yamaguchi M, Enomoto T, Takakuwa K

    The journal of obstetrics and gynaecology research   45 ( 3 )   549 - 555   2019年3月

  • Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015: A JSGO-JSOG joint study. 査読 国際誌

    Machida H, Matsuo K, Yamagami W, Ebina Y, Kobayashi Y, Tabata T, Kanauchi M, Nagase S, Enomoto T, Mikami M

    Gynecologic oncology   153 ( 3 )   589 - 596   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ygyno.2019.03.243

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  • 【卵巣がん征圧へのマイルストーン】JGOG-ToMMoバイオバンキング事業

    島田 宗昭, 峯岸 直子, 八重樫 伸生, 山本 雅之, 榎本 隆之, 杉山 徹

    産婦人科の実際   68 ( 3 )   267 - 271   2019年3月

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    記述言語:日本語   出版者・発行元:金原出版(株)  

    <文献概要>婦人科悪性腫瘍研究機構(JGOG)は,Gynecologic Cancer Intergroup(GCIG)やGynecologic Oncology Group(GOG)へ加入し,データ管理,臨床試験のコーディネートなどのインフラ整備を進め,国際共同第III相試験も主導し,国際的評価に耐えうる臨床研究の成果を報告してきた。近年の医療を取り巻く環境の変化に伴い,JGOGは東北メディカル・メガバンク機構(ToMMo)および臨床研究情報センター(TRI)との連携を進め,公的資金の獲得,Translational Research(TR)の推進,がんゲノム医療の実装化を目指す体制を強化した。JGOG-ToMMoバイオバンキング事業はJGOGの主たる事業であり,新設されたJGOG TR委員会主導のもと,より精密な個別化医療の実装を目指す臨床研究の遂行を可能にするとともに,GCIGなどとの国際連携も強化し,わが国から婦人科悪性腫瘍に対する新たな治療戦略の発信を目指す。

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  • 【卵巣がん征圧へのマイルストーン】卵巣がん二次化学療法に関する臨床試験のこれから 分子標的薬を中心に

    関根 正幸, 榎本 隆之

    産婦人科の実際   68 ( 3 )   257 - 265   2019年3月

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    記述言語:日本語   出版者・発行元:金原出版(株)  

    <文献概要>再発卵巣がんに対する血管新生阻害薬,PARP阻害薬,免疫チェックポイント阻害薬のエビデンスをまとめ,併用療法を中心に今後の展望を解説する。ベバシズマブはBeyond PDの有効性,オラパリブはプラチナ感受性再発に対する患者選択とBRCA検査の位置づけ,ペンブロリズマブはマイクロサテライト不安定性検査の施行時期と陽性率の低さが,今後の議論のポイントである。3つの分子標的薬の併用療法は,各種試験が進行し相乗効果が大きく期待されているが,併用による有害事象プロファイルの変化にも注意が必要である。

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    その他リンク: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00535&link_issn=&doc_id=20190322130005&doc_link_id=10.18888%2Fsp.0000000785&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fsp.0000000785&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • Ectopic pregnancy following oral levonorgestrel emergency contraception use. 査読 国際誌

    Yohei Kitani, Tatsuya Ishiguro, Akiko Kobayashi, Ryo Tamura, Haruka Ueda, Sosuke Adachi, Nobumichi Nishikawa, Masayuki Sekine, Takayuki Enomoto

    The journal of obstetrics and gynaecology research   45 ( 2 )   473 - 476   2019年2月

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    担当区分:最終著者   記述言語:英語  

    Levonorgestrel is used worldwide as an emergency oral contraceptive. There have been occasional reports of ectopic pregnancy after oral levonorgestrel use. We present a case of ectopic tubal pregnancy after the use of oral levonorgestrel as an emergency contraceptive in a 37-year-old woman with a history of treatment for Chlamydia trachomatis infection. She conceived after sexual intercourse on menstrual day 14 of the first menstrual cycle following a normal delivery. After salpingectomy for this right tubal pregnancy, her following pregnancy was an ectopic pregnancy in the contralateral tube, which was treated with laparoscopic salpingectomy. Histopathological examination revealed endometriosis. We should be aware of ectopic pregnancy even after emergency contraceptive use, especially in patients with risk factors, such as Chlamydia infection and endometriosis. Because the efficacy of levonorgestrel decreases after ovulation, we should check the stage of the cycle before prescription.

    DOI: 10.1111/jog.13815

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  • Concurrent isolated retroperitoneal HGSC and STIC defined by somatic mutation analysis: a case report. 査読 国際誌

    Suda K, Nakaoka H, Hata C, Yahata N, Isobe M, Kameyama H, Wakai T, Motoyama T, Inoue I, Yoshihara K, Enomoto T

    Diagnostic pathology   14 ( 1 )   17 - 17   2019年2月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s13000-019-0795-3

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  • 本邦における子宮頸部円錐切除術14,832例の検討 円切後合併症を中心に 「子宮頸部円錐切除術の実態調査」に関する小委員会(日本産科婦人科学会婦人科腫瘍委員会)報告

    中嶋 理恵, 片渕 秀隆, 池田 仁惠, 三上 幹男, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 「子宮頸部円錐切除術の実態調査」に関する小委員会

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 595   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 子宮頸部円錐切除症例の挙児希望症例に関する後方視的検討

    戸澤 晃子, 三上 幹男, 津田 千春, 大原 樹, 鈴木 直, 池田 仁惠, 小林 陽一, 永瀬 智, 横山 正俊, 榎本 隆之, 片渕 秀隆, 「子宮頸部円錐切除術の実態調査」に関する小委員会

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 598   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 本邦における子宮頸部円錐切除術14,832例の検討 施設属性を中心に 「子宮頸部円錐切除術の実態調査」に関する小委員会(日本産科婦人科学会婦人科腫瘍委員会)報告

    荒瀬 透, 片渕 秀隆, 持丸 佳之, 池田 仁惠, 三上 幹男, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 「子宮頸部円錐切除術の実態調査」に関する小委員会

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 596   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 本邦における子宮頸部円錐切除術14,832例の検討 手術器具に関しての検討 「子宮頸部円錐切除術の実態調査」に関する小委員会(日本産科婦人科学会婦人科腫瘍委員会)報告

    林 信孝, 吉岡 信也, 上松 和彦, 青木 卓哉, 池田 仁惠, 三上 幹男, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 片渕 秀隆, 「子宮頸部円錐切除術の実態調査」に関する小委員会

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 595   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 小児の腟原発胎児型横紋筋肉腫の診断と治療に鏡視下手術が有用であった1例

    山岸 葉子, 関根 正幸, 須田 一暁, 茅原 誠, 南川 高廣, 安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 加嶋 克則, 榎本 隆之

    新潟産科婦人科学会会誌   113 ( 2 )   70 - 74   2019年2月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    3歳女児。性器出血と外陰から突出する腫瘤に母親が気づき近医を受診後、精査目的で当科へ紹介となった。初診時、静脈麻酔下に腫瘤生検を行ったが、病理組織診断では悪性所見を認めず、良性の処女膜ポリープとして経過観察していた。しかし、その後も性器出血が持続したため、初診5ヵ月目に全身麻酔下にて硬性子宮鏡を用い腟内を観察したところ、腟壁から無数のポリープ様腫瘤がブドウの房状に発育しており、鏡視下に腫瘤を切除したが、完全切除には至らなかった。病理組織学的に胎児型横紋筋肉腫と確定診断され、術後は4剤併用化学療法と放射線療法を行った。その結果、残存病変は消失し、治療から4年以上経過現在、再発所見は認められていない。

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  • BRCA陰性卵巣癌に対してOlaparib維持療法が有効な1例

    明石 英彦, 吉原 弘祐, 杉野 健太郎, 茅原 誠, 石黒 竜也, 安達 聡介, 磯部 真倫, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 611   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 当院でのプラチナ製剤感受性再発卵巣癌に対するオラパリブ投与に関する検討

    堀内 綾乃, 西川 伸道, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 439   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 鎖肛術後の直腸脱、直腸瘤の一例

    為我井 加菜, 小林 暁子, 長谷川 順紀, 明石 英彦, 工藤 梨紗, 茅原 誠, 石黒 竜也, 安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   113 ( 2 )   83 - 83   2019年2月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 機能性単角子宮を伴う先天性腟閉鎖に対する腹腔鏡下頸管形成造腟術を施行した1例

    小林 暁子, 磯部 真倫, 上田 遥香, 工藤 梨沙, 小木 幹奈, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   113 ( 2 )   99 - 99   2019年2月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 帝王切開後の腹壁創部内膜症

    石黒 竜也, 工藤 梨沙, 茅原 誠, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   113 ( 2 )   92 - 92   2019年2月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 【婦人科腫瘍の新たな治療戦略】卵巣がんの新たな治療戦略 PARP阻害薬

    関根 正幸, 榎本 隆之

    Pharma Medica   37 ( 2 )   19 - 23   2019年2月

  • 【子宮頸がんとHPVワクチンを考える】HPVワクチンの有効性 最近の動向

    関根 正幸, 工藤 梨沙, 山口 真奈子, 安達 聡介, 榎本 隆之

    外来小児科   22 ( 1 )   55 - 60   2019年2月

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    記述言語:日本語   出版者・発行元:(一社)日本外来小児科学会  

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  • Bivalent Human Papillomavirus Vaccine Effectiveness in a Japanese Population: High Vaccine-Type-Specific Effectiveness and Evidence of Cross-Protection. 査読 国際誌

    Risa Kudo, Manako Yamaguchi, Masayuki Sekine, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Megumi Hara, Sharon J B Hanley, Takayuki Enomoto

    The Journal of infectious diseases   219 ( 3 )   382 - 390   2019年1月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Proactive recommendations for human papillomavirus (HPV) vaccines in Japan have been suspended for 5 years because of safety concerns. While no scientific evidence exists to substantiate these concerns, one reason given for not reinstating recommendations is the lack of reliable vaccine effectiveness (VE) data in a Japanese population. This study reports the VE of the bivalent HPV vaccine in Japanese women aged 20-22 years. Methods: During cervical screening between 2014 and 2016, women had Papanicolaou smears and HPV tests performed and provided data about their sexual history. Estimates of VE for vaccine-targeted HPV type 16 (HPV16) and 18 and cross-protection against other types were calculated. Results: Overall, 2197 women were tested, and 1814 were included in the analysis. Of these, 1355 (74.6%) were vaccinated, and 1295 (95.5%) completed the 3-dose schedule. In women sexually naive at vaccination, the pooled VEs against HPV16 and 18 and for HPV31, 45, and 52 were 95.5% (P < .01) and 71.9% (P < .01), respectively. When adjusted for number of sex partners and birth year, pooled VEs were 93.9% (P = .01) and 67.7% (P = .01) for HPV16 and 18 and HPV31, 45, and 52, respectively. Conclusions: The bivalent HPV vaccine is highly effective against HPV16 and 18. Furthermore, significant cross-protection against HPV31, 45, and 52 was demonstrated and sustained up to 6 years after vaccination. These findings should reassure politicians about the VE of bivalent HPV vaccine in a Japanese population.

    DOI: 10.1093/infdis/jiy516

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  • Association of statins, aspirin, and venous thromboembolism in women with endometrial cancer. 査読 国際誌

    Matsuo K, Hom MS, Yabuno A, Shida M, Kakuda M, Adachi S, Mandelbaum RS, Ueda Y, Hasegawa K, Enomoto T, Mikami M, Roman LD

    Gynecologic oncology   152 ( 3 )   605 - 611   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ygyno.2018.12.020

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  • Japan Society of Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer. 査読

    Yasuhiko Ebina, Mikio Mikami, Satoru Nagase, Tsutomu Tabata, Masanori Kaneuchi, Hironori Tashiro, Masaki Mandai, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi, Nobuo Yaegashi, Yasuhiro Udagawa, Daisuke Aoki

    International journal of clinical oncology   24 ( 1 )   1 - 19   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The Japan Society of Gynecologic Oncology (JSGO) Guidelines 2017 for the Treatment of Uterine Cervical Cancer are for the purpose of providing standard treatment strategies for cervical cancer, indicating treatment methods currently considered appropriate for cervical cancer, minimizing variances in treatment methods among institutions, improving the safety of treatment and prognosis of diseases, reducing the economic and psychosomatic burden of patients by promoting performance of appropriate treatment, and enhancing mutual understanding between patients and healthcare professionals. The guidelines were prepared through consensus of the JSGO Guideline Committee, based on careful review of evidence gathered through the literature searches and in view of the medical health insurance system and actual clinical practice situations in Japan. The guidelines comprise eight chapters and five algorithms. The main features of the 2017 revision are as follows: (1) evidence was collected using a search formula and with cooperation of the Japan Library Association. The bibliographical search formula was placed at the end of the book; (2) regarding clinical questions (CQs) where evidence or clinical inspection in Japan was lacking, opinions of the Guidelines Committee were described as "proposals for future directions"; (3) cervical intraepithelial neoplasia (CIN) 3 and adenocarcinoma in situ (AIS) were treated as a cervical precancerous lesion; (4) the CQs of endoscopic surgery, radical trachelectomy, and sentinel node biopsy were newly added in Chapter 3, "primary treatment for stage IB-II cervical cancer"; and (5) the CQ about hormone replacement therapy after cancer treatment was newly established. Each recommendation is accompanied by a classification of recommendation categories based on the consensus reached by the Guideline Committee members. Here, we present the English version of the JSGO Guidelines 2017 for the Treatment of Uterine Cervical Cancer.

    DOI: 10.1007/s10147-018-1351-y

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  • Erratum: Author Correction: Bcl11b controls odorant receptor class choice in mice. 査読

    Enomoto T, Nishida H, Iwata T, Fujita A, Nakayama K, Kashiwagi T, Hatanaka Y, Kondo H, Kajitani R, Itoh T, Ohmoto M, Matsumoto I, Hirota J

    Communications biology   2   343   2019年

  • Beyond resumption of the Japanese Government's recommendation of the HPV vaccine. 査読 国際誌

    Yutaka Ueda, Asami Yagi, Sayaka Ikeda, Takayuki Enomoto, Tadashi Kimura

    The Lancet. Oncology   19 ( 12 )   1563 - 1564   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/S1470-2045(18)30573-4

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  • Differential misclassification between self-reported status and official HPV vaccination records in Japan: Implications for evaluating vaccine safety and effectiveness. 査読 国際誌

    Manako Yamaguchi, Masayuki Sekine, Risa Kudo, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Megumi Hara, Sharon J B Hanley, Takayuki Enomoto

    Papillomavirus research (Amsterdam, Netherlands)   6   6 - 10   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Japan has no national vaccine registry and approximately 1700 municipalities manage the immunization records independently. In June 2013, proactive recommendations for the human papillomavirus (HPV) vaccine were suspended after unconfirmed reports of adverse events following immunization in the media, despite no vaccine safety signal having been raised. Furthermore, studies assessing HPV vaccine safety and effectiveness published post suspension are predominantly based on self-reported information. Our aim was to examine the accuracy of self-reported vaccination status compared with official municipal records. Participants were women aged 20-22 yrs, who were attending for cervical screening in Niigata city. Among the 1230 eligible registrants, vaccine uptake, defined as any dose, was 75.0% and 77.2% according to a self-reported questionnaire and municipal records, respectively. The accuracy rate of self-reported information was as follows: positive predictive value (PPV) was 87.7%; negative predictive value (NPV) was 54.5%; sensitivity was 85.2%; and specificity was 59.8%. The validity of self-reported information was only moderate (Kappa statistic = 0.44, 95% confidence interval 0.37-0.50). This combined with the low NPV may lead to reduced estimation of effectiveness and safety. A more reliable method, such as a national HPV vaccine registry, needs to be established for assessing HPV immunization status in Japan.

    DOI: 10.1016/j.pvr.2018.05.002

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  • Annual report of the committee on gynecologic oncology, the Japan Society of Obstetrics and Gynecology: Annual patients report for 2015 and annual treatment report for 2010. 査読

    Nagase S, Ohta T, Takahashi F, Enomoto T, Committee on, Gynecologic Oncology of, the Japan, Society of Obstetrics, Gynecology

    The journal of obstetrics and gynaecology research   45 ( 2 )   289 - 298   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jog.13863

    Web of Science

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  • Proposal for a Risk-Based Categorization of Uterine Carcinosarcoma. 査読 国際誌

    Koji Matsuo, Yutaka Takazawa, Malcolm S Ross, Esther Elishaev, Mayu Yunokawa, Todd B Sheridan, Stephen H Bush, Merieme M Klobocista, Erin A Blake, Tadao Takano, Tsukasa Baba, Shinya Satoh, Masako Shida, Yuji Ikeda, Sosuke Adachi, Takuhei Yokoyama, Munetaka Takekuma, Shiori Yanai, Satoshi Takeuchi, Masato Nishimura, Keita Iwasaki, Marian S Johnson, Masayuki Yoshida, Ardeshir Hakam, Hiroko Machida, Paulette Mhawech-Fauceglia, Yutaka Ueda, Kiyoshi Yoshino, Hiroshi Kajiwara, Kosei Hasegawa, Masanori Yasuda, Takahito M Miyake, Takuya Moriya, Yoshiaki Yuba, Terry Morgan, Tomoyuki Fukagawa, Tanja Pejovic, Tadayoshi Nagano, Takeshi Sasaki, Abby M Richmond, Miriam D Post, Mian M K Shahzad, Dwight D Im, Hiroshi Yoshida, Takayuki Enomoto, Kohei Omatsu, Frederick R Ueland, Joseph L Kelley, Rouzan G Karabakhtsian, Lynda D Roman

    Annals of surgical oncology   25 ( 12 )   3676 - 3684   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To propose a categorization model of uterine carcinosarcoma (UCS) based on tumor cell types (carcinoma and sarcoma) and sarcoma dominance. METHODS: This secondary analysis of a prior multicenter retrospective study examined 889 cases of UCS with available histologic evaluation. Based on survival outcome, cases were clustered into three groups: low-grade carcinoma with nondominant homologous sarcoma [type A, n = 96 (10.8%)], (1) low-grade carcinoma with heterologous sarcoma or any sarcoma dominance and (2) high-grade carcinoma with nondominant homologous sarcoma [type B, n = 412 (46.3%)], and high-grade carcinoma with heterologous sarcoma or any sarcoma dominance [type C, n = 381 (42.9%)]. Tumor characteristics and outcome were examined based on the categorization. RESULTS: Women in type C category were more likely to be older, obese, and Caucasian, whereas those in type A category were younger, less obese, Asian, and nulligravid (all P < 0.01). Type C tumors were more likely to have metastatic implants, large tumor size, lymphovascular space invasion with sarcoma cells, and higher lymph node ratio, whereas type A tumors were more likely to be early-stage disease and small (all P < 0.05). On multivariate analysis, tumor categorization was independently associated with progression-free survival (5-year rates: 70.1% for type A, 48.3% for type B, and 35.9% for type C, adjusted P < 0.01) and cause-specific survival (5-year rates: 82.8% for type A, 63.0% for type B, and 47.1% for type C, adjusted P < 0.01). CONCLUSION: Characteristic differences in clinicopathological factors and outcomes in UCS imply that different underlying etiologies and biological behaviors may be present, supporting a new classification system.

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  • Novel MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma. 査読 国際誌

    Ryo Tamura, Hirofumi Nakaoka, Kosuke Yoshihara, Yutaro Mori, Nozomi Yachida, Nobumichi Nishikawa, Teiichi Motoyama, Shujiro Okuda, Ituro Inoue, Takayuki Enomoto

    Genes, chromosomes & cancer   57 ( 11 )   557 - 563   2018年11月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Primary ovarian sarcomas are extremely rare tumors, and their genomic and transcriptomic alterations remain to be elucidated. We performed whole exome sequencing of primary tumor and matched normal blood samples derived from one patient with ovarian undifferentiated small round cell sarcoma. We identified 8 nonsynonymous somatic mutations, and all mutations were missense or nonsense changes. Next, we performed RNA sequencing of the tumor sample and identified two in-frame fusion transcripts: MXD4-NUTM1 and ARL6-POT1. Most NUTM1 exons were retained in the MXD4-NUTM1 fusion transcript, and we confirmed an increase in NUTM1 mRNA and protein expression in tumor tissue. Further genomic and transcriptomic analyses might lead to the development of new therapeutic strategies based on the molecular characteristics of ovarian undifferentiated small round cell sarcoma.

    DOI: 10.1002/gcc.22668

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  • Trachelectomy for stage IB1 cervical cancer with tumor size &gt;2 cm: trends and characteristics in the United States. 査読 国際誌

    Matsuo K, Machida H, Mandelbaum RS, Mikami M, Enomoto T, Roman LD, Wright JD

    Journal of gynecologic oncology   29 ( 6 )   e85   2018年11月

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  • A Japanese survey of malignant disease in pregnancy. 査読

    Kobayashi Y, Tabata T, Omori M, Kondo E, Hirata T, Yoshida K, Sekine M, Itakura A, Enomoto T, Ikeda T

    International journal of clinical oncology   24 ( 3 )   328 - 333   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10147-018-1352-x

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  • Myomectomy scar ectopic pregnancy following a cryopreserved embryo transfer. 査読

    Ishiguro T, Yamawaki K, Chihara M, Nishikawa N, Enomoto T

    Reproductive medicine and biology   17 ( 4 )   509 - 513   2018年10月

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    記述言語:英語  

    DOI: 10.1002/rmb2.12212

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  • HPVワクチン接種による子宮頸がん検診細胞診異常例におけるハイリスクHPV感染率の変化

    工藤 梨沙, 関根 正幸, 山口 真奈子, 安達 聡介, 八木 麻美, 上田 豊, 原 めぐみ, Hanley Sharon, 宮城 悦子, 榎本 隆之

    日本癌治療学会学術集会抄録集   56回   PS - 6   2018年10月

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    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

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  • Author Correction: Dynamic changes in Japan's prevalence of abnormal findings in cervical cytology depending on birth year. 査読 国際誌

    Yutaka Ueda, Asami Yagi, Tomio Nakayama, Kei Hirai, Sayaka Ikeda, Masayuki Sekine, Etsuko Miyagi, Takayuki Enomoto

    Scientific reports   8 ( 1 )   13384 - 13384   2018年9月

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    記述言語:英語  

    A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

    DOI: 10.1038/s41598-018-31652-7

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  • A single pheromone receptor gene conserved across 400 million years of vertebrate evolution. 査読

    Suzuki H, Nishida H, Kondo H, Yoda R, Iwata T, Nakayama K, Enomoto T, Wu J, Moriya-Ito K, Miyazaki M, Wakabayashi Y, Kishida T, Okabe M, Suzuki Y, Ito T, Hirota J, Nikaido M

    Molecular biology and evolution   35 ( 12 )   2928 - 2939   2018年9月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/molbev/msy186

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  • Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma. 査読 国際誌

    Koji Matsuo, Yutaka Takazawa, Malcolm S Ross, Esther Elishaev, Mayu Yunokawa, Todd B Sheridan, Stephen H Bush, Merieme M Klobocista, Erin A Blake, Tadao Takano, Tsukasa Baba, Shinya Satoh, Masako Shida, Yuji Ikeda, Sosuke Adachi, Takuhei Yokoyama, Munetaka Takekuma, Shiori Yanai, Satoshi Takeuchi, Masato Nishimura, Keita Iwasaki, Marian S Johnson, Masayuki Yoshida, Ardeshir Hakam, Hiroko Machida, Paulette Mhawech-Fauceglia, Yutaka Ueda, Kiyoshi Yoshino, Hiroshi Kajiwara, Kosei Hasegawa, Masanori Yasuda, Takahito M Miyake, Takuya Moriya, Yoshiaki Yuba, Terry Morgan, Tomoyuki Fukagawa, Tanja Pejovic, Tadayoshi Nagano, Takeshi Sasaki, Abby M Richmond, Miriam D Post, Mian M K Shahzad, Dwight D Im, Hiroshi Yoshida, Takayuki Enomoto, Kohei Omatsu, Frederick R Ueland, Joseph L Kelley, Rouzan G Karabakhtsian, Lynda D Roman

    Annals of surgical oncology   25 ( 9 )   2756 - 2766   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). METHODS: This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I-IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma; n = 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma; n = 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome. RESULTS: Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all p < 0.05). On multivariate analysis, LVSI-sarcoma was independently associated with decreased progression-free survival (5-year rates: 34.9 vs. 40.8%, adjusted hazard ratio [HR] 1.84, 95% confidence interval [CI] 1.36-2.50, p < 0.001), and cause-specific survival (5-year rates: 41.8 vs. 55.9%, adjusted HR 1.95, 95% CI 1.39-2.75, p < 0.001) compared with LVSI-carcinoma. Postoperative radiotherapy for women with LVSI-sarcoma had a higher reduction rate of recurrence/progression of disease (54% reduction, p = 0.04) compared with postoperative radiotherapy for women with LVSI-carcinoma (26% reduction, p = 0.08). CONCLUSION: In UCS, the presence of a sarcomatous component in LVSI is particularly prevalent when a tumor has sarcoma dominance. Our study suggests that LVSI containing a sarcomatous component may be a predictor of decreased survival for women with UCS.

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  • 地域医療における専攻医の全腹腔鏡下子宮全摘術(TLH)研修

    明石 英彦, 磯部 真倫, 小池 公美, 石田 道雄, 榎本 隆之

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   66回   0122 - 0122   2018年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • 帝王切開既往症例における膀胱挙上、癒着に対する腹腔鏡下子宮全摘術時の膀胱剥離の定型化

    小林 暁子, 磯部 真倫, 上田 遥香, 小木 幹奈, 工藤 梨沙, 茅原 誠, 石黒 竜也, 吉原 弘祐, 安達 聡介, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   113 ( 1 )   21 - 25   2018年9月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    腹腔鏡下子宮全摘術(TLH)を施行した既往帝王切開31例を対象とし、定型化した帝王切開術後の膀胱剥離法を開始前の3例(42〜51歳)と開始後28例(41〜62歳)であった。手術適応では、開始後で子宮体癌の症例数が11例と多かった。開腹への移行、膀胱損傷など、手技に関係する術中・術後の合併症は認めなかった。入院期間、手術時間に顕著な差は認めなかったが、出血量は開始後で少ない傾向にあった。

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  • Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium. 査読 国際誌

    Kazuaki Suda, Hirofumi Nakaoka, Kosuke Yoshihara, Tatsuya Ishiguro, Ryo Tamura, Yutaro Mori, Kaoru Yamawaki, Sosuke Adachi, Tomoko Takahashi, Hiroaki Kase, Kenichi Tanaka, Tadashi Yamamoto, Teiichi Motoyama, Ituro Inoue, Takayuki Enomoto

    Cell reports   24 ( 7 )   1777 - 1789   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Endometriosis is characterized by ectopic endometrial-like epithelium and stroma, of which molecular characteristics remain to be fully elucidated. We sequenced 107 ovarian endometriotic and 82 normal uterine endometrial epithelium samples isolated by laser microdissection. In both endometriotic and normal epithelium samples, numerous somatic mutations were identified within genes frequently mutated in endometriosis-associated ovarian cancers. KRAS is frequently mutated in endometriotic epithelium, with a higher mutant allele frequency (MAF) accompanied by arm-level allelic imbalances. Analyses of MAF, combined with multiregional sequencing, illuminated spatiotemporal evolution of the endometriosis and uterine endometrium genomes. We sequenced 109 single endometrial glands and found that each gland carried distinct cancer-associated mutations, demonstrating the heterogeneity of the genomic architecture of endometrial epithelium. Remarkable increases in MAF of mutations in cancer-associated genes in endometriotic epithelium suggest retrograde flow of endometrial cells already harboring cancer-associated mutations, with selective advantages at ectopic sites, leading to the development of endometriosis.

    DOI: 10.1016/j.celrep.2018.07.037

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  • Characteristics and outcomes of reproductive-aged women with early-stage cervical cancer: trachelectomy versus hysterectomy. 査読 国際誌

    Machida H, Mandelbaum RS, Mikami M, Enomoto T, Sonoda Y, Grubbs BH, Paulson RJ, Roman LD, Wright JD, Matsuo K

    American journal of obstetrics and gynecology   219 ( 5 )   461.e1 - 461.e18   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ajog.2018.08.020

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  • 女性の家族性がん 新潟県におけるHBOC診療体制の確立に向けての取り組み

    西野 幸治, 須田 一暁, 安達 聡介, 吉原 弘祐, 関根 正幸, 榎本 隆之, 五十嵐 真由子, 土田 純子, 中島 真人, 永橋 昌幸, 田澤 立之, 栗山 洋子, 藤田 沙織里, 小山 諭, 菊池 朗, 佐藤 信昭, 金子 耕司, 田村 恵美子, 三富 亜希, 後藤 清恵

    人間ドック   33 ( 2 )   232 - 232   2018年8月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • 腹腔鏡による迅速な診断が可能であった悪性リンパ腫の一例

    西野 幸治, 安達 聡介, 明石 英彦, 工藤 梨沙, 茅原 誠, 石黒 竜也, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   202 - 202   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 機能性子宮体部を持つ先天性腟・頸管欠損症に対する腹腔鏡下広汎頸部摘出術を応用した腹腔鏡下形成手術

    小林 暁子, 磯部 真倫, 上田 遥香, 工藤 梨沙, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   399 - 399   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 腹腔鏡下子宮全摘術後、尿管損傷が判明した症例

    安達 聡介, 磯部 真倫, 小林 暁子, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   314 - 314   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • ミューラー管由来組織の遺残を認めた完全型アンドロゲン不応症

    石黒 竜也, 安達 聡介, 茅原 誠, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   363 - 363   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 離島における専攻医の全腹腔鏡下子宮全摘術(TLH)研修

    明石 英彦, 磯部 真倫, 小池 公美, 石田 道雄, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   185 - 185   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • The use of conization to identify and treat severe lesions among prediagnosed CIN1 and 2 patients in Japan. 査読 国際誌

    Mikami M, Ikeda M, Sato H, Iwase H, Enomoto T, Kobayashi Y, Katabuchi H

    Journal of gynecologic oncology   29 ( 4 )   e46   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3802/jgo.2018.29.e46

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  • 【婦人科がん-研究・臨床の新展開】遺伝性乳癌卵巣癌(HBOC) 遺伝性乳癌卵巣癌(HBOC)の診断と治療の今後

    関根 正幸, 榎本 隆之

    医学のあゆみ   266 ( 1 )   121 - 126   2018年7月

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

    Olaparibが、生殖細胞系列BRCA遺伝子変異(gBRCAm)を有する再発卵巣癌ではなく、プラチナ感受性再発卵巣癌の維持療法を対象として国内販売が開始された。この承認のもとになったのは第III相試験であるSOLO2であり、gBRCAm再発卵巣癌を対象に、Olaparib錠の維持療法群で無増悪期間(PFS)の大幅な延長を認めていた(19.1ヵ月vs.5.5ヵ月)。プラチナ感受性再発を対象としているのは第II相試験であるstudy 19であり、カプセル剤の維持療法群でPFSの有意な延長が示されていた(8.4ヵ月vs.4.8ヵ月。PARP阻害薬の作用機序は、gBRCAmを含む相同組換え修復異常(HRD)に伴う合成致死が主なものである。プラチナ製剤によるDNA二本鎖間の架橋形成の修復時には、DNAの複製がはじまると損傷部位は二本鎖切断に至り相同組換え修復(HR)が必要となり、臨床的にプラチナ感受性を示す症例が、このHRD statusをよく反映していることから、PARP阻害薬の感受性を予測するサロゲートマーカーとして用いられている。わが国の卵巣癌におけるgBRCAmの頻度は12〜13%であり、米国ではすべての卵巣癌患者にBRCA遺伝子検査が推奨されているが、家族歴、既往歴、組織型も念頭においた推奨を提唱している国もある。今後SOLO1の結果により、gBRCAm卵巣癌患者を対象とした初回維持療法でolaparibの適応が承認され、乳癌に続いてBRCA遺伝子検査が卵巣癌治療のコンパニオン診断となる可能性が高い。卵巣癌治療を行う各主治医が、BRCA遺伝子検査に関する検査前説明を日常外来で行いうる体制を早急に整備しなくてはならない。(著者抄録)

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    その他リンク: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00060&link_issn=&doc_id=20180710020020&doc_link_id=issn%3D0039-2359%26volume%3D266%26issue%3D1%26spage%3D121&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0039-2359%26volume%3D266%26issue%3D1%26spage%3D121&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

  • Postoperative chemotherapy for node-positive cervical cancer: Results of a multicenter phase II trial (JGOG1067) 査読

    Maki Matoda, Nobuhiro Takeshima, Hirofumi Michimae, Takashi Iwata, Harushige Yokota, Yutaka Torii, Yorito Yamamoto, Kazuhiro Takehara, Shin Nishio, Hirokuni Takano, Mika Mizuno, Yoshiyuki Takahashi, Yuji Takei, Tetsuya Hasegawa, Mikio Mikami, Takayuki Enomoto, Daisuke Aoki, Toru Sugiyama

    Gynecologic Oncology   149 ( 3 )   513 - 519   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Academic Press Inc.  

    Objective: This multicenter phase II Japanese Gynecologic Oncology Group study (JGOG1067) was designed to evaluate the efficacy and safety of postoperative chemotherapy in patients with node-positive cervical cancer. Methods: Patients with stage IB–IIA squamous cervical cancer who underwent radical hysterectomy and were confirmed to have pelvic lymph node metastasis were eligible for this study. The patients postoperatively received irinotecan (CPT-11
    60 mg/m2 intravenously on days 1 and 8) and nedaplatin (NDP
    80 mg/m2 intravenously on day 1). Chemotherapy administration commenced within 6 weeks after surgery and was repeated every 28 days for up to 5 cycles. The primary endpoint of this study was the 2-year recurrence-free survival (RFS) rate. The secondary endpoints were the 5-year overall survival (OS) rate, 5-year RFS rate, and adverse events such as complications of chemotherapy and lower-limb edema. Results: Sixty-two patients were analyzed according to our protocol, among whom 55 (88.7%) completed 5 cycles of scheduled treatment. The median follow-up period was 66.1 months (range, 16.8–96.6 months). The 2-year and 5-year RFS rates were 87.1% (95% confidence interval [CI]: 75.9–99.3) and 77.2% (95% CI: 64.5–85.8), respectively. Fourteen patients (22.5%) experienced recurrence during the follow-up period, 8 of whom died of the disease. The 5-year OS rate in this study was 86.5% (95% CI: 74.8–93.0). Only 9.7% of the patients experienced lymphedema in their legs. Conclusion: Postoperative chemotherapy without radiotherapy was found to be very effective in high-risk patients with node-positive cervical cancer.

    DOI: 10.1016/j.ygyno.2018.04.009

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  • Postoperative chemotherapy for node-positive cervical cancer: Results of a multicenter phase II trial (JGOG1067) 査読

    Matoda, M, Takeshima, N, Michimae, H, Iwata, T, Yokota, H, Torii, Y, Yamamoto, Y, Takehara, K, Nishio, S, Takano, H, Mizuno, M, Takahashi, Y, Takei, Y, Hasegawa, T, Mikami, M, Enomoto, T, Aoki, D, Sugiyama, T

    Gynecol Oncol   149 ( 3 )   513 - 519   2018年6月

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    OBJECTIVE: This multicenter phase II Japanese Gynecologic Oncology Group study (JGOG1067) was designed to evaluate the efficacy and safety of postoperative chemotherapy in patients with node-positive cervical cancer. METHODS: Patients with stage IB-IIA squamous cervical cancer who underwent radical hysterectomy and were confirmed to have pelvic lymph node metastasis were eligible for this study. The patients postoperatively received irinotecan (CPT-11; 60mg/m(2) intravenously on days 1 and 8) and nedaplatin (NDP; 80mg/m(2) intravenously on day 1). Chemotherapy administration commenced within 6weeks after surgery and was repeated every 28days for up to 5cycles. The primary endpoint of this study was the 2-year recurrence-free survival (RFS) rate. The secondary endpoints were the 5-year overall survival (OS) rate, 5-year RFS rate, and adverse events such as complications of chemotherapy and lower-limb edema. RESULTS: Sixty-two patients were analyzed according to our protocol, among whom 55 (88.7%) completed 5cycles of scheduled treatment. The median follow-up period was 66.1months (range, 16.8-96.6months). The 2-year and 5-year RFS rates were 87.1% (95% confidence interval [CI]: 75.9

    DOI: 10.1016/j.ygyno.2018.04.009

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  • Significance of abnormal peritoneal cytology on survival of women with stage I–II endometrioid endometrial cancer 査読

    Koji Matsuo, Akira Yabuno, Marianne S. Hom, Masako Shida, Mamoru Kakuda, Sosuke Adachi, Rachel S. Mandelbaum, Yutaka Ueda, Kosei Hasegawa, Takayuki Enomoto, Mikio Mikami, Lynda D. Roman

    Gynecologic Oncology   149 ( 2 )   301 - 309   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Academic Press Inc.  

    Objective: To examine survival of women with stage I–II endometrioid endometrial cancer whose peritoneal cytology showed malignant or atypical cells (abnormal peritoneal cytology). Methods: This is a multi-center retrospective study examining 1668 women with stage I–II endometrioid endometrial cancer who underwent primary hysterectomy with available peritoneal cytology results between 2000 and 2015. Abnormal peritoneal cytology was correlated to clinico-pathological characteristics and oncological outcome. Results: Malignant and atypical cells were seen in 125 (7.5%) and 58 (3.5%) cases, respectively. On multivariate analysis, non-obesity, non-diabetes mellitus, cigarette use, and lympho-vascular space invasion were independently associated with abnormal peritoneal cytology (all, P &lt
    0.05). Abnormal peritoneal cytology was independently associated with decreased disease-free survival (hazard ratio 3.07, P &lt
    0.001) and cause-specific survival (hazard ratio 3.42, P = 0.008) on multivariate analysis. Abnormal peritoneal cytology was significantly associated with increased risks of distant-recurrence (5-year rates: 8.8% versus 3.6%, P = 0.001) but not local-recurrence (5.2% versus 3.0%, P = 0.32) compared to negative cytology. Among women with stage I disease, abnormal peritoneal cytology was significantly associated with an increased risk of distant-recurrence in the low risk group (5-year rates: 5.5% versus 1.0%, P &lt
    0.001) but not in the high-intermediate risk group (13.3% versus 10.8% P = 0.60). Among 183 women who had abnormal peritoneal cytology, postoperative chemotherapy significantly reduced the rate of peritoneal recurrence (5-year rates: 1.3% versus 9.2%, P = 0.039) whereas postoperative radiotherapy did not (7.1% versus 5.5%, P = 0.63). Conclusion: Our study suggests that abnormal peritoneal cytology may be a prognostic factor for decreased survival in women with stage I–II endometrioid endometrial cancer, particularly for low-risk group.

    DOI: 10.1016/j.ygyno.2018.02.012

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  • The Safety and Effectiveness of Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer During Pregnancy 査読

    Kosuke Yoshihara, Tatsuya Ishiguro, Makoto Chihara, Eiri Shima, Sosuke Adachi, Masanori Isobe, Kazufumi Haino, Masayuki Yamaguchi, Masayuki Sekine, Katsunori Kashima, Koichi Takakuwa, Nobumichi Nishikawa, Takayuki Enomoto

    International Journal of Gynecological Cancer   28 ( 4 )   782 - 787   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Lippincott Williams and Wilkins  

    Objectives: Cervical cancer is one of the most frequently diagnosed cancers in pregnancy. Our aim was to evaluate the safety and efficacy of abdominal radical trachelectomy (ART) for pregnant women with early-stage cervical cancer who strongly desire to preserve their pregnancies. Methods/Materials: A retrospective observational study was performed for stage IB1 cervical cancer patients who underwent ART or radical hysterectomy (RH) at our hospital between February 2013 and June 2017. We compared differences in perioperative findings and oncologic outcomes among ART during pregnancy (ART-DP), ART, and RH groups. Results: A total of 38 patients were included in this analysis. Six, 10, and 22 patients were assigned to the ART-DP, ART, and RH groups, respectively. There were no significant differences in the distribution of pathological TNM classifications, histology, tumor size, stromal invasion, and lymph-vascular space invasion among the 3 groups. The patients in the ART-DP group were younger than those in the RH group (P = 0.014). The ART-DP group was associated with more blood loss and prolonged surgery compared with the RH group (P = 0.017 and P = 0.014). The number of total lymph nodes in the ART-DP group was lower than that in the RH group (P = 0.036). However, there were no significant differences in age, surgical time, blood loss, or lymph node count between the ART-DP and ART groups. There were no significant differences in progression-free and overall survival times among the 3 groups, and no recurrence was observed in the ART-DP group. Conclusions: Abdominal radical trachelectomy may be a tolerable treatment option for pregnant women with early-stage cervical cancer who strongly desire a baby.

    DOI: 10.1097/IGC.0000000000001218

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  • 消化器合併切除 (特集 卵巣癌の手術up to date)

    西川 伸道, 島田 能史, 若井 俊文, 吉野 潔, 榎本 隆之

    産婦人科の実際 = Obstetrical and gynecological practice   67 ( 5 )   503 - 508   2018年5月

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    記述言語:日本語   出版者・発行元:金原出版  

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  • Dynamic changes in Japan's prevalence of abnormal findings in cervical cervical cytology depending on birth year. 査読 国際誌

    Yutaka Ueda, Asami Yagi, Tomio Nakayama, Kei Hirai, Sayaka Ikeda, Masayuki Sekine, Etsuko Miyagi, Takayuki Enomoto

    Scientific reports   8 ( 1 )   5612 - 5612   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Japan's governmental recommendation of HPV vaccine has now been suspended for more than 4 years. In and before 2013, the targets of 20-year-old cervical cancer screening were females born in and before 1993, i.e., those who could not have received HPV vaccination because it was not yet publicly introduced. The targets during 2014-2019 are, or will be, those born in 1994-1999, i.e., those who came of age during a period with the highest HPV immunization rate. We analyzed the statistical data for each birth year, for the cumulative HPV vaccination rates achieved as of age 16, and for the corresponding results of cervical cancer screening at age 20. The rate of abnormal findings in cervical cytology increased slightly from 3.68% in 2010 (birth year: 1990) to 4.35% in 2013 (birth year: 1993); however, it dynamically dropped to 2.99% in 2014 (birth year: 1994) and 3.03% in 2015 (birth year: 1995). In total, the rate of abnormal findings in cervical cytology was 3.96% in 2010-2013, but significantly dropped to 3.01% in 2014-2015 (p = 0.014). This is the first description of dynamic changes occurring in the abnormal rate of cervical cancer screening as a result of positive changes in national HPV vaccination rates.

    DOI: 10.1038/s41598-018-23947-6

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  • Microdissection testicular sperm extraction in five Japanese patients with non-mosaic Klinefelter's syndrome 査読

    Makoto Chihara, Kanna Ogi, Tatsuya Ishiguro, Kunihiko Yoshida, Chikako Godo, Koichi Takakuwa, Takayuki Enomoto

    Reproductive Medicine and Biology   17 ( 2 )   209 - 216   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:John Wiley and Sons Ltd  

    Cases: Microdissection testicular sperm extraction (micro-TESE) was performed on five Japanese men with non-mosaic Klinefelter's syndrome (KS) and non-obstructive azoospermia in the authors' department. Here is reported the operative results and partner's clinical course for two cases where spermatozoa could be acquired. Also encountered was a man with non-mosaic KS with the partial deletion of azoospermia factor (AZF)b. Because this is rare, it is reported in detail in the context of the previous literature. This case series describes the first experience of micro-TESE by gynecologists in the current department. Outcome: The egg collection date was adjusted to the micro-TESE day by using the modified ultra-long method. Intracytoplasmic sperm injection (ICSI) was implemented for two men whose spermatozoa were acquired by micro-TESE, with these progressing to the blastocyst stage. Subsequently, one case conceived after the transfer of fresh embryos and a healthy baby was delivered. However, spermatozoa could not be retrieved from the man with non-mosaic KS who was harboring the partial deletion of AZFb. Conclusion: These findings suggest that ovulation induction by using the modified ultra-long method with micro-TESE and ICSI on the same day represents an effective treatment option for men with non-mosaic KS. As there are cases where AZF deletion is recognized among patients with non-mosaic KS, screening before micro-TESE is strongly recommended.

    DOI: 10.1002/rmb2.12092

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  • Genetic and clinical characteristics in Japanese hereditary breast and ovarian cancer: first report after establishment of HBOC registration system in Japan. 査読 国際誌

    Masami Arai, Shiro Yokoyama, Chie Watanabe, Reiko Yoshida, Mizuho Kita, Megumi Okawa, Akihiro Sakurai, Masayuki Sekine, Junko Yotsumoto, Hiroyuki Nomura, Yoshinori Akama, Mayuko Inuzuka, Tadashi Nomizu, Takayuki Enomoto, Seigo Nakamura

    Journal of human genetics   63 ( 4 )   447 - 457   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The hereditary breast and ovarian cancer (HBOC) registration system of Japan was established by the Japanese HBOC Consortium. The first trial was registered in 2015 in four institutions to which some registration committee members belonged. We analyzed the information of 830 Japanese pedigrees, who underwent BRCA1/2 genetic testing, including mutation carriers with BRCA1 (N = 127) and BRCA2 (N = 115), and their families. The mutation-positive rate was 19.7%. Variants of uncertain significance were found in 6.5% of all individuals subjected to genetic testing for BRCA1/2. Compared to the United States, Japan had a higher mutation-positive rate in most categories, except for the groups with male breast cancer. Among the intrinsic subtypes of BRCA1-associated breast cancers, 75.8% were triple-negative. The incidence rate of contralateral breast cancer in BRCA1/2 mutation carriers was 0.99%/year. Among 240 mutation carriers, 26 and 62 patients underwent risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO), respectively; the respective frequencies of occult cancer were 7.1 and 3.2%. Metachronous breast cancer after RRM or peritoneal cancer after RRSO was not observed during the follow-up period. The nationwide registration system began last year and the system enables follow-up analysis in Japan.

    DOI: 10.1038/s10038-017-0355-1

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  • Correction: Genetic and clinical characteristics in Japanese hereditary breast and ovarian cancer: first report after establishment of HBOC registration system in Japan. 査読 国際誌

    Arai M, Yokoyama S, Watanabe C, Yoshida R, Kita M, Okawa M, Sakurai A, Sekine M, Yotsumoto J, Nomura H, Akama Y, Inuzuka M, Nomizu T, Enomoto T, Nakamura S

    Journal of human genetics   63 ( 4 )   541 - 542   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s10038-017-0395-6

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  • Motivating Mothers to Recommend Their 20-Year-Old Daughters Receive Cervical Cancer Screening: A Randomized Study. 査読

    Tomomi Egawa-Takata, Yutaka Ueda, Akiko Morimoto, Yusuke Tanaka, Asami Yagi, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Yumiko Hori, Eiichi Morii, Tomio Nakayama, Mikiko Asai-Sato, Etsuko Miyagi, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    Journal of epidemiology   28 ( 3 )   156 - 160   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: In Japan, the rate of cervical cancer screening is remarkably low, especially among women in their twenties and thirties, when cervical cancer is now increasing dramatically. The aim of this study was to test whether a modified government reminder for 20-year-old women to engage in cervical cancer screening, acting through maternal education and by asking for a maternal recommendation to the daughter to receive the screening, could increase their participation rate. METHODS: In two Japanese cities, 20-year-old girls who had not received their first cervical cancer screening before October of fiscal year 2014 were randomized into two study arms. One group of 1,274 received only a personalized daughter-directed reminder leaflet for cervical cancer screening. In the second group of 1,274, the daughters and their mothers received a combination package containing the same reminder leaflet as did the first group, plus an additional informational leaflet for the mother, which requested that the mother recommend that her daughter undergo cervical cancer screening. The subsequent post-reminder screening rates of these two study arms were compared. RESULTS: The cervical cancer screening rate of 20-year-old women whose mothers received the information leaflet was significantly higher than that for women who received only a leaflet for themselves (11% vs 9%, P = 0.0049). CONCLUSIONS: An intervention with mothers, by sending them a cervical cancer information leaflet with a request that they recommend that their daughter receive cervical cancer screening, significantly improved their daughters' screening rate.

    DOI: 10.2188/jea.JE20160155

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  • 【婦人科がん(第2版)-最新の研究動向-】 卵巣がん 卵巣癌の治療 PARP阻害薬

    関根 正幸, 榎本 隆之

    日本臨床   76 ( 増刊2 婦人科がん )   640 - 645   2018年3月

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    記述言語:日本語   出版者・発行元:(株)日本臨床社  

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  • 当科における胞状奇胎症例の後方視的検討

    森 裕太郎, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    北海道産科婦人科学会会誌   62 ( 1 )   230 - 230   2018年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • 医師の人材育成における「メンター制度」の有効性 新潟県における腹腔鏡手術の教育から得たもの

    磯部 真倫, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    北海道産科婦人科学会会誌   62 ( 1 )   221 - 221   2018年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • Malignancy during pregnancy in Japan: An exceptional opportunity for early diagnosis 査読

    Masayuki Sekine, Yoshiyuki Kobayashi, Tsutomu Tabata, Tamotsu Sudo, Ryuichiro Nishimura, Koji Matsuo, Brendan H. Grubbs, Takayuki Enomoto, Tomoaki Ikeda

    BMC Pregnancy and Childbirth   18 ( 1 )   50   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BioMed Central Ltd.  

    Background: Malignancy during pregnancy has become a significant cause of maternal death in developed countries, likely due to both an older pregnant population, and increases of cervical cancer in younger women. Our aim is to investigate the clinical aspects of malignancy during pregnancy in Japan and to use this information to identify opportunities for earlier detection and treatment. Methods: We provided a questionnaire to 1508 secondary or tertiary care hospitals in Japan. We reviewed the clinical characteristics of cases with malignancy during pregnancy for the period of January to December, 2008. From the 760 institutions which responded, we obtained clinical information for 227 unique cases. The questionnaire provided clinical information, including disease site, pregnancy outcome and how the disease was detected. Results: The most common type of malignancy was cervical cancer (n=162, 71.4%) followed by ovarian (n=16, 7.0%) and breast cancer (n=15, 6.6%). Leukemia (n=7, 3.1%), colon cancer (n=5, 2.2%), gastric cancer (n=5, 2.2%), malignant lymphoma (n=4, 1.8%), thyroid cancer (n=3, 1.3%), brain cancer (n=3, 1.3%), endometrial cancer (n=2, 0.9%), and head and neck cancer (n=2, 0.9%) accounted for the remaining cases. Overall, gynecological malignancies accounted for 79.3% (95% confidence interval 74.0-84.6) of pregnancy associated malignancies diagnosed in the present study. The majority of cervical cancers, 149 (92.0%) of 162, were diagnosed by a Pap (Papanicolaou) smear during early gestation. Ten (62.5%) of the ovarian cancer cases were diagnosed by ultrasonography during a prenatal checkup or at the time of initial pregnancy diagnosis. Out of 14 breast cancers, only one (7.1%) was diagnosed by screening breast exam. Conclusions: From this study, we reaffirm the clear and significant benefits of prenatal checkups starting at an early gestational age for the detection of gynecological cancers during pregnancy. Conversely, breast cancer detection during pregnancy was poor, suggesting new strategies for early identification of this disease are required.

    DOI: 10.1186/s12884-018-1678-4

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  • 本邦における子宮頸部円錐切除術14,832例の検討 切除断端陽性例を中心に 「子宮頸部円錐切除術の実態調査」に関する小委員会(日本産科婦人科学会 婦人科腫瘍委員会)報告

    矢坂 美和, 池田 仁惠, 平澤 猛, 柴田 健雄, 三上 幹男, 小林 陽一, 永瀬 智, 横山 正俊, 榎本 隆之, 片渕 秀隆, 「子宮頸部円錐切除術の実態調査」に関する小委員会

    日本産科婦人科学会雑誌   70 ( 2 )   647 - 647   2018年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 分娩後1年以内の子宮頸部円錐切除症例の後方視的解析 子宮頸部円錐切除術の実態調査に関する小委員会(婦人科腫瘍委員会)報告

    田中 良道, 寺井 義人, 古形 祐平, 大道 正英, 池田 仁惠, 三上 幹男, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 片渕 秀隆, 「子宮頸部円錐切除術の実態調査」に関する小委員会

    日本産科婦人科学会雑誌   70 ( 2 )   846 - 846   2018年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 妊娠中子宮頸部円錐切除症例の後方視的解析 子宮頸部円錐切除術の実態調査に関する小委員会(婦人科腫瘍委員会)報告

    古形 祐平, 寺井 義人, 田中 良道, 大道 正英, 池田 仁惠, 三上 幹男, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 片渕 秀隆, 「子宮頸部円錐切除術の実態調査」に関する小委員会

    日本産科婦人科学会雑誌   70 ( 2 )   846 - 846   2018年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 本邦における診断的円錐切除症例の検討

    山本 瑠美子, 三上 幹男, 関谷 健太郎, 寺川 耕市, 樋口 壽宏, 池田 仁惠, 榎本 隆之, 小林 陽一, 永瀬 智, 横山 正俊, 片渕 秀隆, 子宮頸部円錐切除術の実態調査に関する小委員会

    日本産科婦人科学会雑誌   70 ( 2 )   656 - 656   2018年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 本邦における子宮頸部円錐切除術14,832例の検討 円錐切除後妊娠例を中心に 「子宮頸部円錐切除術の実態調査」に関する小委員会(日本産科婦人科学会 婦人科腫瘍委員会)報告

    楢山 知明, 池田 仁惠, 信田 政子, 柴田 健雄, 三上 幹男, 小林 陽一, 永瀬 智, 横山 正俊, 榎本 隆之, 片渕 秀隆, 「子宮頸部円錐切除術の実態調査」に関する小委員会

    日本産科婦人科学会雑誌   70 ( 2 )   649 - 649   2018年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • Japan CHARLOTTE study 卵巣癌に対するBRCA遺伝学的検査に関する横断研究 中間報告

    鶴田 智彦, 榎本 隆之, 青木 大輔, 渡部 洋, 紀川 純三, 竹島 信宏, 藤川 慶太, 陣内 辰徳, 杉山 徹, Japan CHARLOTTE study

    日本産科婦人科学会雑誌   70 ( 2 )   648 - 648   2018年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. 査読 国際誌

    Ryo Tamura, Kosuke Yoshihara, Tetsuya Saito, Ryosuke Ishimura, Juan Emmanuel Martínez-Ledesma, Hu Xin, Tatsuya Ishiguro, Yutaro Mori, Kaoru Yamawaki, Kazuaki Suda, Seiya Sato, Hiroaki Itamochi, Teiichi Motoyama, Yoichi Aoki, Shujiro Okuda, Cristine R Casingal, Hirofumi Nakaoka, Ituro Inoue, Roel G W Verhaak, Masaaki Komatsu, Takayuki Enomoto

    Oncogenesis   7 ( 1 )   4 - 4   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We previously found that therapeutic targetable fusions are detected across various cancers. To identify therapeutic targetable fusion in uterine cervical cancer, for which no effective gene targeted therapy has yet been clinically applied, we analyzed RNA sequencing data from 306 cervical cancer samples. We detected 445 high confidence fusion transcripts and identified four samples that harbored FGFR3-TACC3 fusion as an attractive therapeutic target. The frequency of FGFR3-TACC3-fusion-positive cervical cancer is also 1.9% (2/103) in an independent cohort. Continuous expression of the FGFR3-TACC3 fusion transcript and protein induced anchorage-independent growth in the cervical epithelial cell line established from the ectocervix (Ect1/E6E7) but not in that from endocervix (End1/E6E7). Injection of FGFR3-TACC3 fusion-transfected-Ect1/E6E7 cells subcutaneously into NOG mice generated squamous cell carcinoma xenograft tumors, suggesting the association between FGFR3-TACC3 fusion and squamous cell carcinogenesis. Transfection of a FGFR3-TACC3 fusion transcript into four cervical cancer cell lines (SiHa, ME180, HeLa, and Ca Ski) induced activation of the MAPK pathway and enhancement of cell proliferation. Transcriptome analysis of the FGFR3-TACC3 fusion-transfected cell lines revealed that an IL8-triggered inflammatory response was increased, via activation of FGFR3-MAPK signaling. Continuous expression of FGFR3-TACC3 fusion led to activation of the PI3K-AKT pathway only in the two cell lines that harbored PIK3CA mutations. Sensitivity to the FGFR inhibitor, BGJ398, was found to depend on PIK3CA mutation status. Dual inhibition of both FGFR and AKT showed an obvious synergistic effect in cell lines that harbor mutant PIK3CA. Additionally, TACC3 inhibitor, KHS101, suppressed FGFR3-TACC3 fusion protein expression and showed antitumor effect against FGFR3-TACC3 fusion-transfected cell lines. FGFR3-TACC3 fusion-positive cancer has frequent genetic alterations of the PI3K/AKT pathway and selection of appropriate treatment based on PI3K/AKT pathway status should be required.

    DOI: 10.1038/s41389-017-0018-2

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  • LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake. 査読 国際誌

    Kosuke Hiramatsu, Satoshi Serada, Takayuki Enomoto, Yusuke Takahashi, Satoshi Nakagawa, Satoshi Nojima, Akiko Morimoto, Shinya Matsuzaki, Takuhei Yokoyama, Tsuyoshi Takahashi, Minoru Fujimoto, Hiroshi Takemori, Yutaka Ueda, Kiyoshi Yoshino, Eiichi Morii, Tadashi Kimura, Tetsuji Naka

    Cancer research   78 ( 2 )   516 - 527   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, but it still lacks effective treatment options. In this study, we utilized proteomic technology to identify lipolysis-stimulated lipoprotein receptor (LSR) as a new tumor antigen of EOC. Immunohistochemical analysis of EOC tissues in conjunction with survival analysis of EOC patients showed that high expression of LSR is associated with poor prognosis. High LSR expression also occurred in tumor metastases including to the lymph node and omentum. To evaluate the possible benefits of blocking this antigen in EOC, we raised a new monoclonal antibody (mAb) to human LSR (hLSR). In mouse xenograft models of hLSR+ EOC (cell lines or patient-derived tumors), we found that administration of anti-hLSR mAb inhibited tumor growth in a manner independent of both antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Mechanistic investigations showed that hLSR expression increased incorporation of very-low-density lipoprotein (VLDL) into EOC cells and that anti-hLSR mAb inhibited lipid uptake in vitro and in vivo Moreover, VLDL promoted cell proliferation in hLSR-positive EOC cells in vitro, and this effect was inhibited by anti-hLSR mAb. While the anti-hLSR mAb studied cross reacted with the mouse antigen, we observed no adverse effects on normal organs and lipid metabolism in murine hosts. Our findings suggest that hLSR plays a key functional role in EOC development and that this antigen can be therapeutically targeted by specific mAb to improve EOC treatment.Significance: These findings offer preclinical evidence of the therapeutic efficacy of a novel targeted antibody therapy against deadly epithelial ovarian cancers. Cancer Res; 78(2); 516-27. ©2017 AACR.

    DOI: 10.1158/0008-5472.CAN-17-0910

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  • Effectiveness of fetal cardiac screening for congenital heart disease using a combination of the four-chamber view and three-vessel view during the second trimester scan 査読

    Mina Itsukaichi, Takehiro Serikawa, Kosuke Yoshihara, Hiroshi Suzuki, Kazufumi Haino, Masayuki Yamaguchi, Takayuki Enomoto, Koichi Takakuwa, Hiroshi Aida, Masato Arakawa, Michio Ishida, Hiroaki Kase, Takaaki Sato, Naoto Sekizuka, Akira Honda, Niigata Fetal Cardiac Screening Study Group

    Journal of Obstetrics and Gynaecology Research   44 ( 1 )   49 - 53   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing  

    Aim: We aimed to assess the accuracy and effectiveness of fetal cardiac screening for congenital heart disease (CHD) during the second trimester by general obstetricians in a non-selected population. Methods: In this multicenter, prospective cohort study of fetal cardiac screening, four-chamber and three-vessel views were recorded by obstetricians at 18–21 gestational weeks (GW). A total of 3005 fetuses that were scheduled for delivery at our institution were included. Results: Thirty-seven newborns were born with CHD (1.2%). On excluding 23 cases of ventricular septal defects, the prenatal detection rate of CHD was 42.8%. Although six cases (75.0%) of severe structural abnormality were diagnosed prenatally, the prenatal detection rate of valvular abnormalities was 0%. Conclusion: One-point ultrasound screening of the fetal heart using a combination of four-chamber and three-vessel views at 18–21 GW by general obstetricians in a non-selected population may be useful for detecting severe structural abnormalities but not valvular abnormalities. However, this limitation may be improved by conducting another fetal cardiac screening at approximately 30 GW along with the routine use of color Doppler.

    DOI: 10.1111/jog.13472

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  • Time-dependent changes of the intention of mothers in Japan to inoculate their daughters with the HPV vaccine after suspension of governmental recommendation. 査読 国際誌

    Asami Yagi, Yutaka Ueda, Yusuke Tanaka, Ruriko Nakae, Reisa Kakubari, Akiko Morimoto, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Noriomi Matsumura, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Sayaka Ikeda, Mikiko Asai-Sato, Etsuko Miyagi, Masayuki Sekine, Takayuki Enomoto, Kei Hirai, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    Human vaccines & immunotherapeutics   14 ( 10 )   2497 - 2502   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In Japan, the trend for cervical cancer at younger ages has been increasing. As a countermeasure, the HPV vaccine was introduced as a routine vaccination in April 2013. However, the Ministry of Health, Labour and Welfare (MHLW) announced a "Suspension of its active inoculation recommendation for HPV vaccine" in June 2013. In 2016, 32 months after that suspension, we conducted survey via Internet and compared the results with our previous ones conducted at 9 and 23 months after suspension (in 2014 and 2015, respectively). We examined the 'time-dependent change' of the 'intention of mothers to inoculate their daughters with the HPV vaccine' in terms of efficacy of external decision-making support. 17.5% of mothers in the first survey replied that they would inoculate their daughters under the current circumstances, 12.1% in the second survey, and 6.7% in the third, showing a consistent decrease in willingness over time (p = 0.03, p < 0.01). If the government recommendation were to be reintroduced, 22.5% of mothers in the first survey replied they would inoculate their daughters, 21.0% in the second survey, which indicated no significant difference (p = 0.65) over the first interval; however, this was significantly decreased to 12.2% in the third survey (p < 0.01). Our study revealed that the intention to inoculate their daughters has been declining among Japanese mothers over time triggered by the suspension.

    DOI: 10.1080/21645515.2018.1480240

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  • 医師の人材育成における「メンター」の有効性

    磯部 真倫, 榎本 隆之

    日本内視鏡外科学会雑誌   22 ( 7 )   SF108 - 07   2017年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内視鏡外科学会  

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  • 「それぞれの癌」最善の治療とは? ヒト乳頭腫ウイルス(HPV)関連癌の治療と予防戦略 日本の子宮頸がん予防対策 実効性がある戦略を探る

    宮城 悦子, 鈴木 幸雄, 助川 明子, 元木 葉子, 佐藤 美紀子, 上田 豊, 関根 正幸, 榎本 隆之

    日本癌治療学会学術集会抄録集   55回   SY7 - 5   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • Correction to Lancet Oncol 2017; 18: 1274–84 (The Lancet Oncology (2017) 18(9) (1274–1284) (S1470204517304692) (10.1016/S1470-2045(17)30469-2)) 査読

    Eric Pujade-Lauraine, the, Jonathan A Ledermann, Frédéric Selle, Val Gebski, Richard T Penson, Amit M Oza, Jacob Korach, Tomasz Huzarski, Andrés Poveda, Sandro Pignata, Michael Friedlander, Nicoletta Colombo, Philipp Harter, Keiichi Fujiwara, Isabelle Ray-Coquard, Susana Banerjee, Joyce Liu, Elizabeth S Lowe, Ralph Bloomfield, Patricia Pautier, Jacob Korach, Tomasz Huzarski, Tomasz Byrski, Patricia Pautier, Philipp Harter, Nicoletta Colombo, Sandro Pignata, Giovanni Scambia, Maria Nicoletto, Fiona Nussey, Andrew Clamp, Richard Penson, Amit Oza, Andrés Poveda Velasco, Manuel Rodrigues, Jean-Pierre Lotz, Frédéric Selle, Isabelle Ray-Coquard, Diane Provencher, Aleix Prat Aparicio, Laura Vidal Boixader, Clare Scott, Kenji Tamura, Mayu Yunokawa, Alla Lisyanskaya, Jacques Medioni, Nicolas Pécuchet, Coraline Dubot, Thibault de la Motte Rouge, Marie-Christine Kaminsky, Béatrice Weber, Alain Lortholary, Christine Parkinson, Jonathan Ledermann, Sarah Williams, Susana Banerjee, Jonathan Cosin, James Hoffman, Richard Penson, Marie Plante, Allan Covens, Gabe Sonke, Florence Joly, Anne Floquet, Susana Banerjee, Holger Hirte, Amnon Amit, Tjoung-Won Park-Simon, Koji Matsumoto, Sergei Tjulandin, Jae Hoon Kim, Laurence Gladieff, Roberto Sabbatini, David O'Malley, Patrick Timmins, Daniel Kredentser, Nuria Laínez Milagro, Maria Pilar Barretina Ginesta, Ariadna Tibau Martorell, Alfonso Gómez de Liaño Lista, Belén Ojeda González, Linda Mileshkin, Masaki Mandai, Ingrid Boere, Petronella Ottevanger, Joo-Hyun Nam, Elias Filho, Salima Hamizi, Francesco Cognetti, David Warshal, Elizabeth Dickson-Michelson, Scott Kamelle, Nathalie McKenzie, Gustavo Rodriguez, Deborah Armstrong, Eva Chalas, Paul Celano, Kian Behbakht, Susan Davidson, Stephen Welch, Limor Helpman, Ami Fishman, Ilan Bruchim, Magdalena Sikorska, Anna Słowińska, Wojciech Rogowski, Mariusz Bidziński, Beata Śpiewankiewicz, Antonio Casado Herraez, César Mendiola Fernández, Martina Gropp-Meier, Toshiaki Saito, Kazuhiro Takehara, Takayuki Enomoto, Hidemichi Watari, Chel Hun Choi, Byoung-Gie Kim, Jae Weon Kim, Roberto Hegg, Ignace Vergote

    The Lancet Oncology   18 ( 9 )   1274 - 1284   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Lancet Publishing Group  

    Background Olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, has previously shown efficacy in a phase 2 study when given in capsule formulation to all-comer patients with platinum-sensitive, relapsed high-grade serous ovarian cancer. We aimed to confirm these findings in patients with a BRCA1 or BRCA2 (BRCA1/2) mutation using a tablet formulation of olaparib. Methods This international, multicentre, double-blind, randomised, placebo-controlled, phase 3 trial evaluated olaparib tablet maintenance treatment in platinum-sensitive, relapsed ovarian cancer patients with a BRCA1/2 mutation who had received at least two lines of previous chemotherapy. Eligible patients were aged 18 years or older with an Eastern Cooperative Oncology Group performance status at baseline of 0–1 and histologically confirmed, relapsed, high-grade serous ovarian cancer or high-grade endometrioid cancer, including primary peritoneal or fallopian tube cancer. Patients were randomly assigned 2:1 to olaparib (300 mg in two 150 mg tablets, twice daily) or matching placebo tablets using an interactive voice and web response system. Randomisation was stratified by response to previous platinum chemotherapy (complete vs partial) and length of platinum-free interval (6–12 months vs ≥12 months) and treatment assignment was masked for patients, those giving the interventions, data collectors, and data analysers. The primary endpoint was investigator-assessed progression-free survival and we report the primary analysis from this ongoing study. The efficacy analyses were done on the intention-to-treat population
    safety analyses included patients who received at least one dose of study treatment. This trial is registered with ClinicalTrials.gov, number NCT01874353, and is ongoing and no longer recruiting patients. Findings Between Sept 3, 2013, and Nov 21, 2014, we enrolled 295 eligible patients who were randomly assigned to receive olaparib (n=196) or placebo (n=99). One patient in the olaparib group was randomised in error and did not receive study treatment. Investigator-assessed median progression-free survival was significantly longer with olaparib (19·1 months [95% CI 16·3–25·7]) than with placebo (5·5 months [5·2–5·8]
    hazard ratio [HR] 0·30 [95% CI 0·22–0·41], p&lt
    0·0001). The most common adverse events of grade 3 or worse severity were anaemia (38 [19%] of 195 patients in the olaparib group vs two [2%] of 99 patients in the placebo group), fatigue or asthenia (eight [4%] vs two [2%]), and neutropenia (ten [5%] vs four [4%]). Serious adverse events were experienced by 35 (18%) patients in the olaparib group and eight (8%) patients in the placebo group. The most common in the olaparib group were anaemia (seven [4%] patients), abdominal pain (three [2%] patients), and intestinal obstruction (three [2%] patients). The most common in the placebo group were constipation (two [2%] patients) and intestinal obstruction (two [2%] patients). One (1%) patient in the olaparib group had a treatment-related adverse event (acute myeloid leukaemia) with an outcome of death. Interpretation Olaparib tablet maintenance treatment provided a significant progression-free survival improvement with no detrimental effect on quality of life in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation. Apart from anaemia, toxicities with olaparib were low grade and manageable. Funding AstraZeneca.

    DOI: 10.1016/S1470-2045(17)30469-2

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  • 子宮頸がんの動向 大阪府がん登録データを用いた子宮頸がんの疫学的解析

    八木 麻未, 上田 豊, 中江 瑠璃子, 角張 玲沙, 松崎 慎哉, 吉野 潔, 榎本 隆之, 伊藤 ゆり, 中山 富雄, 木村 正

    日本癌学会総会記事   76回   P - 2383   2017年9月

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    記述言語:英語   出版者・発行元:日本癌学会  

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  • 深化 TLHこんな時どうする 教育、普及する側から見たTLH難症例への対応

    磯部 真倫, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   358 - 358   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 腹腔鏡で診断治療した卵巣妊娠の1例

    小林 暁子, 郷戸 千賀子, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   112 ( 1 )   47 - 47   2017年8月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 癌性腹膜炎との鑑別に腹腔鏡下生検が有用であった結核性腹膜炎の2例

    上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1460 - 1460   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 当院における前回帝王切開症例の膀胱挙上、癒着に対する剥離の工夫

    小林 暁子, 磯部 真倫, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1501 - 1501   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 非認定研修施設での修練による技術認定取得過程の考察

    古俣 大, 磯部 真倫, 南川 高廣, 浅野 堅策, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   885 - 885   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 当科で経験した腹腔鏡手術中における器具破損・紛失症例について

    安達 聡介, 磯部 真倫, 上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 吉原 弘祐, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1153 - 1153   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • アニマルラボ改革 大人数でスキルアップし満足度を上げることは可能なのか?

    磯部 真倫, 安達 聡介, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   112 ( 1 )   49 - 49   2017年8月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • The significance of activated PI3K/AKT pathway in FGFR3-TACC3 fusion positive cervical cancer 査読

    Tamura Ryo, Yoshihara Kosuke, Saito Tetsuya, Ishimura Ryosuke, Martinez-Ledesma Emmanuel, Mori Yutaro, Yamawaki Kaoru, Suda Kazuaki, Ishiguro Tatsuya, Aoki Yoichi, Sato Seiya, Itamochi Hiroaki, Komatsu Masaaki, Verhaak Roeland, Enomoto Takayuki

    CANCER RESEARCH   77   2017年7月

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  • Anesthetic management of abdominal radical trachelectomy for uterine cervical cancer during pregnancy 査読

    Jun Terukina, Misako Takamatsu, Takayuki Enomoto, Hiroshi Baba

    JOURNAL OF ANESTHESIA   31 ( 3 )   467 - 471   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    Abdominal radical trachelectomy has been identified as a surgical option for fertility preservation in cervical cancer patients, particularly in pregnant women who strongly desire to continue their pregnancy. Since this procedure requires operating in the uterus, the hardness of the uterus can affect the ease of surgery. Generally, sevoflurane is used for anesthesia in non-obstetric surgery for pregnant women because uterine relaxation is advantageous for uterine blood flow maintenance. However, the use of sevoflurane during radical trachelectomy has not been thoroughly evaluated. Here, we report on anesthesia use in three cases of abdominal radical trachelectomy during pregnancy. Propofol enabled maintenance of uterine tension while not significantly affecting fetal growth. It is important to consider maintenance of uterine tension and fetal circulation in anesthesia management. During the operation, we performed an ultrasound examination every 30 min to confirm fetal well-being. Although frequent fetal heart rate monitoring of the pre-viable fetus is not recommended, if fetal bradycardia is detected, sevoflurane may then be used to improve fetal circulation. Additionally, if the fetal heartbeat stops, a radical hysterectomy would then be required. Therefore, we consider that fetal heart rate monitoring during this procedure is necessary, and propofol is suitable as an anesthetic for this surgery during pregnancy.

    DOI: 10.1007/s00540-017-2325-3

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  • Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism 査読

    Yadav Sapkota, Valgerdur Steinthorsdottir, Andrew P. Morris, Amelie Fassbender, Nilufer Rahmioglu, Immaculata De Vivo, Julie E. Buring, Futao Zhang, Todd L. Edwards, Sarah Jones, O. Dorien, Danielle Peterse, Kathryn M. Rexrode, Paul M. Ridker, Andrew J. Schork, Stuart MacGregor, Nicholas G. Martin, Christian M. Becker, Sosuke Adachi, Kosuke Yoshihara, Takayuki Enomoto, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Michiaki Kubo, Gudmar Thorleifsson, Reynir T. Geirsson, Unnur Thorsteinsdottir, Leanne M. Wallace, Jian Yang, Digna R. Velez Edwards, Mette Nyegaard, Siew-Kee Low, Krina T. Zondervan, Stacey A. Missmer, Thomas D'Hooghe, Grant W. Montgomery, Daniel I. Chasman, Kari Stefansson, Joyce Y. Tung, Dale R. Nyholt

    NATURE COMMUNICATIONS   8   15539   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P&lt;5 x 10(-8)), implicating genes involved in sex steroid hormone pathways (FN1, CCDC170, ESR1, SYNE1 and FSHB). Conditional analysis identified five secondary association signals, including two at the ESR1 locus, resulting in 19 independent single nucleotide polymorphisms (SNPs) robustly associated with endometriosis, which together explain up to 5.19% of variance in endometriosis. These results highlight novel variants in or near specific genes with important roles in sex steroid hormone signalling and function, and offer unique opportunities for more targeted functional research efforts.

    DOI: 10.1038/ncomms15539

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  • Recurrent ovarian undifferentiated carcinoma resembling hepatoid morphology treated with pegylated liposomal doxorubicin and bevacizumab 査読

    Tatsuya Ishiguro, Kastunori Kashima, Nozomi Yachida, Teiichi Motoyama, Takayuki Enomoto

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   43 ( 5 )   957 - 961   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Hepatoid carcinomas are undifferentiated epithelial carcinomas that are pathologically similar to hepatocellular carcinoma, but occur in a variety of organs. Hepatoid carcinomas, as strictly defined, typically produce a-fetoprotein. In addition, a standard effective chemotherapy regimen for hepatoid carcinoma has yet to be established. We present a case of advanced primary ovarian cancer that was pathologically similar to hepatoid carcinoma without staining for a-fetoprotein or hepatocyte paraffin 1. The primary ovarian, metastatic, and recurrent tumors shared similar pathological characteristics. Fourth-line chemotherapy with pegylated liposomal doxorubicin and bevacizumab was effective in treating the recurrent tumor, even though this disease had recurred three times.

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  • Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer 査読

    Kaoru Yamawaki, Tatsuya Ishiguro, Yutaro Mori, Kosuke Yoshihara, Kazuaki Suda, Ryo Tamura, Masayuki Yamaguchi, Masayuki Sekine, Katsunori Kashima, Masaya Higuchi, Masahiro Fujii, Koji Okamoto, Takayuki Enomoto

    CANCER SCIENCE   108 ( 4 )   632 - 640   2017年4月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Sex-determining region Y-box 2 (SOX2) is an essential factor involved in the self-renewal and pluripotency of embryonic stem cells and has functions in cell survival and progression in many types of cancers. Here, we found that several endometrial cancer cell lines expressed SOX2, which was required for cell growth. Additionally, SOX2 overexpression regulated the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A), and SOX2 specifically bound to p21 promoter DNA in endometrial cancer cell lines expressing SOX2. Expressions of SOX2 in endometrial cancer patients were significantly correlated with histological grade and poor prognosis. Moreover, low p21 together with high SOX2 expressions inadvanced endometrial cancer patients were associated with the most unfavorable outcomes of patients. These results indicated that simultaneous measurement of SOX2 and p21 expression in endometrial cancer patients may be a useful biomarker for patient prognosis.

    DOI: 10.1111/cas.13196

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  • Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer. 査読 国際誌

    Kaoru Yamawaki, Tatsuya Ishiguro, Yutaro Mori, Kosuke Yoshihara, Kazuaki Suda, Ryo Tamura, Masayuki Yamaguchi, Masayuki Sekine, Katsunori Kashima, Masaya Higuchi, Masahiro Fujii, Koji Okamoto, Takayuki Enomoto

    Cancer science   108 ( 4 )   632 - 640   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Sex-determining region Y-box 2 (SOX2) is an essential factor involved in the self-renewal and pluripotency of embryonic stem cells and has functions in cell survival and progression in many types of cancers. Here, we found that several endometrial cancer cell lines expressed SOX2, which was required for cell growth. Additionally, SOX2 overexpression regulated the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A), and SOX2 specifically bound to p21 promoter DNA in endometrial cancer cell lines expressing SOX2. Expressions of SOX2 in endometrial cancer patients were significantly correlated with histological grade and poor prognosis. Moreover, low p21 together with high SOX2 expressions in advanced endometrial cancer patients were associated with the most unfavorable outcomes of patients. These results indicated that simultaneous measurement of SOX2 and p21 expression in endometrial cancer patients may be a useful biomarker for patient prognosis.

    DOI: 10.1111/cas.13196

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  • Mutations of the KLF1 gene detected in Japanese with the In(Lu) phenotype. 査読

    Kawai M, Obara K, Onodera T, Enomoto T, Ogasawara K, Tsuneyama H, Uchikawa M, Inaba S

    Transfusion   57 ( 4 )   1072 - 1077   2017年4月

  • Comparison of Different Recruitment Methods for Sexual and Reproductive Health Research: Social Media-Based Versus Conventional Methods. 査読

    Motoki Y, Miyagi E, Taguri M, Asai-Sato M, Enomoto T, Wark JD, Garland SM

    Journal of medical Internet research   19 ( 3 )   e73 - e73   2017年3月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2196/jmir.7048

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  • Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications 査読

    Tatsuya Ishiguro, Hirokazu Ohata, Ai Sato, Kaoru Yamawaki, Takayuki Enomoto, Koji Okamoto

    Cancer Science   108 ( 3 )   283 - 289   2017年3月

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    記述言語:英語   出版者・発行元:Blackwell Publishing Ltd  

    Recently, many types of in vitro 3-D culture systems have been developed to recapitulate the in vivo growth conditions of cancer. The cancer 3-D culture methods aim to preserve the biological characteristics of original tumors better than conventional 2-D monolayer cultures, and include tumor-derived organoids, tumor-derived spheroids, organotypic multicellular spheroids, and multicellular tumor spheroids. The 3-D culture methods differ in terms of cancer cell sources, protocols for cell handling, and the required time intervals. Tumor-derived spheroids are unique because they are purposed for the enrichment of cancer stem cells (CSCs) or cells with stem cell-related characteristics. These spheroids are grown as floating spheres and have been used as surrogate systems to evaluate the CSC-related characteristics of solid tumors in vitro. Because eradication of CSCs is likely to be of clinical importance due to their association with the malignant nature of cancer cells, such as tumorigenicity or chemoresistance, the investigation of tumor-derived spheroids may provide invaluable clues to fight against cancer. Spheroid cultures have been established from cancers including glioma, breast, colon, ovary, and prostate cancers, and their biological and biochemical characteristics have been investigated by many research groups. In addition to the investigation of CSCs, tumor-derived spheroids may prove to be instrumental for a high-throughput screening platform or for the cultivation of CSC-related tumor cells found in the circulation or body fluids.

    DOI: 10.1111/cas.13155

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  • Comparison of Different Recruitment Methods for Sexual and Reproductive Health Research: Social Media-Based Versus Conventional Methods 査読

    Yoko Motoki, Etsuko Miyagi, Masataka Taguri, Mikiko Asai-Sato, Takayuki Enomoto, John Dennis Wark, Suzanne Marie Garland

    JOURNAL OF MEDICAL INTERNET RESEARCH   19 ( 3 )   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JMIR PUBLICATIONS, INC  

    Background
    Prior research about the sexual and reproductive health of young women has relied mostly on self-reported survey studies. Thus, participant recruitment using Web-based methods can improve sexual and reproductive health research about cervical cancer prevention. In our prior study, we reported that Facebook is a promising way to reach young women for sexual and reproductive health research. However, it remains unknown whether Web-based or other conventional recruitment methods (ie, face-to-face or flyer distribution) yield comparable survey responses from similar participants.
    Objective
    We conducted a survey to determine whether there was a difference in the sexual and reproductive health survey responses of young Japanese women based on recruitment methods: social media-based and conventional methods.
    Methods
    From July 2012 to March 2013 (9 months), we invited women of ages 16-35 years in Kanagawa, Japan, to complete a Web-based questionnaire. They were recruited through either a social media-based (social networking site, SNS, group) or by conventional methods (conventional group). All participants enrolled were required to fill out and submit their responses through a Web-based questionnaire about their sexual and reproductive health for cervical cancer prevention.
    Results
    Of the 243 participants, 52.3% (127/243) were recruited by SNS, whereas 47.7% (116/243) were recruited by conventional methods. We found no differences between recruitment methods in responses to behaviors and attitudes to sexual and reproductive health survey, although more participants from the conventional group (15%, 14/95) chose not to answer the age of first intercourse compared with those from the SNS group (5.2%, 6/116; P=.03).
    Conclusions
    No differences were found between recruitment methods in the responses of young Japanese women to a Web-based sexual and reproductive health survey.

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  • Biochemical analysis of intraplacental choriocarcinoma and fetomaternal transfusion 査読

    Tatsuya Ishiguro, Kazuaki Suda, Takayuki Enomoto

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   43 ( 3 )   587 - 591   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Intraplacental choriocarcinoma is one of the rarest forms of gestational tumors and is believed to be one of the causes of fetomaternal transfusion (FMT). A 35-year-old woman, gravida 2, para 2, with a history of two vaginal deliveries, was incidentally diagnosed as having stage I gestational intraplacental choriocarcinoma with a FIGO/World Health Organization 2000 risk score of 2 after term delivery. This disease caused neonatal anemia but did not metastasize to either the mother or infant. Short tandem repeat analysis with laser microdissection revealed that the tumor had originated from the current pregnancy. Serological test and immunohistochemical analysis revealed that the patient and her baby suffered from FMT. She has been free from disease without any medical intervention for the last 1 year. A combination of multiple biochemical analyses might help us diagnose the precursor pregnancy of a gestational choriocarcinoma and FMT.

    DOI: 10.1111/jog.13232

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  • Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy 査読

    Tatsuya Ishiguro, Takehiro Serikawa, Tetsuro Yahata, Takayuki Enomoto

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   43 ( 2 )   421 - 424   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Gestational choriocarcinoma metastasizing to the bones, especially to the spine, is extremely rare. In addition, there are few reports of choriocarcinoma during a viable pregnancy. We report a case of gestational choriocarcinoma that metastasized to the lumbar spine during a viable pregnancy in a 41-year-old woman with a history of a missed abortion. A heterogeneous cervical mass was detected at gestational week 16. Subsequently, a metastatic lesion appeared during the pregnancy, and fetal demise in utero occurred. Pathological examination revealed that the cervical tumor and metastatic spinal tumor were choriocarcinoma. The patient's condition deteriorated rapidly and we were unable to save her life, despite multidrug chemotherapy. Surgical tumor resection and pregnancy might involve a substantial risk of choriocarcinoma metastasis. It is important to obtain an early diagnosis for this life-threatening disease in order to facilitate appropriate treatment, despite pregnancy.

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  • Realistic fear of cervical cancer risk in Japan depending on birth year 査読

    Asami Yagi, Yutaka Ueda, Tomomi Egawa-Takata, Yusuke Tanaka, Ruriko Nakae, Akiko Morimoto, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Yumiko Hori, Eiichi Morii, Tomio Nakayama, Yukio Suzuki, Yoko Motoki, Akiko Sukegawa, Mikiko Asai-Sato, Etsuko Miyagi, Manako Yamaguchi, Risa Kudo, Sosuke Adachi, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    HUMAN VACCINES & IMMUNOTHERAPEUTICS   13 ( 7 )   1700 - 1704   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS INC  

    Objective: In Japan, the possible adverse events upon HPV vaccination was widely reported in the media. MHLW announced the suspension of aggressively encouraging HPV vaccination in 2013, and inoculation rate has sharply declined. The aim of the present study was estimation of future cervical cancer risk.
    Methods: The latest data on vaccination rate at each age in Sakai City were first investigated. The rate of experiencing sexual intercourse at the age of 12, 13, 14, 15, 16, 17 and throughout lifetime is assumed to be 0%, 1%, 2%, 5%, 15%, 25%, and 85% respectively. The cervical cancer risk was regarded to be proportional to the relative risk of HPV infection over the lifetime. The risk in those born in 1993 whom HPV vaccination was not available yet for was defined to be 1.0000.
    Results: The cumulative vaccination rates were 65.8% in those born in 1994, 72.7% in 1995, 72.8% in 1996, 75.7% in 1997, 75.0% in 1998, 66.8% in 1999, 4.1% in 2000, 1.5% in 2001, 0.1% in 2002, and 0.1% in 2003. The relative cervical cancer risk in those born in 1994-1999 was reduced to 0.56-0.70, however, the rate in those born in 2000-2003 was 0.98-1.0, almost the same risk as before introduction of the vaccine.
    Discussion: The cumulative initial vaccination rates were different by the year of birth. It is confirmed that the risk of future cervical cancer differs in accordance with the year of birth. For these females, cervical cancer screening should be recommended more strongly.

    DOI: 10.1080/21645515.2017.1292190

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  • Project conducted in Hirakata to improve cervical cancer screening rates in 20-year-old Japanese: Influencing parents to recommend that their daughters undergo cervical cancer screening 査読

    Asami Yagi, Yutaka Ueda, Tomomi Egawa-Takata, Yusuke Tanaka, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Yumiko Hori, Eiichi Morii, Tomio Nakayama, Yukio Suzuki, Yoko Motoki, Akiko Sukegawa, Mikiko Asai-Sato, Etsuko Miyagi, Manako Yamaguchi, Risa Kudo, Sosuke Adachi, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   42 ( 12 )   1802 - 1807   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Aim: In Japan, the rate of routine cervical cancer screening is quite low, and the incidence of cervical cancer has recently been increasing. Our objective was to investigate ways to effectively influence parental willingness to recommend that their 20-year-old daughters undergo cervical cancer screening.
    Methods: We targeted parents whose 20-year-old daughters were living with them. In fiscal year 2013, as usual, the daughter received a reminder postcard several months after they had received a free coupon for cervical cancer screening. In fiscal year 2014, the targeted parents received a cervical cancer information leaflet, as well as a cartoon about cervical cancer to show to their daughters, with a request that they recommend to their daughter that she undergo cervical cancer screening. The subsequent screening rates for fiscal years 2013 and 2014 were compared.
    Results: The cervical cancer screening rate of 20-year-old women whose parents received the information packet in fiscal year 2014 was significantly higher than for the women who, in fiscal year 2013, received only a simple reminder postcard (P &lt; 0.001). As a result, the total screening rate for 20-year-old women for the whole of the 2014 fiscal year was significantly increased over 2013 (P &lt; 0.001).
    Conclusion: For the first time, we have shown that the parents of 20-year-old daughters can be motivated to recommend that their daughters receive their first cervical cancer screening. This was achieved by sending a cervical cancer information leaflet and a cartoon about cervical cancer for these parents to show to their daughters. This method was significantly effective for improving cervical cancer screening rates.

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  • 内視鏡外科技術認定医への道 その先に求められるもの 医師の人材育成における「メンター制度」の有効性 新潟県における腹腔鏡手術教育から得たもの

    磯部 真倫, 榎本 隆之

    日本内視鏡外科学会雑誌   21 ( 7 )   SS6 - 6   2016年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内視鏡外科学会  

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  • Mothers' attitudes in Japan regarding cervical cancer screening correlates with intention to recommend cervical cancer screening for daughters 査読

    Tomomi Egawa-Takata, Yutaka Ueda, Yusuke Tanaka, Akiko Morimoto, Satoshi Kubota, Asami Yagi, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Risa Kudo, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   21 ( 5 )   962 - 968   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    Cervical cancer and its precancerous lesions caused by human papilloma virus (HPV) are steadily increasing in women in Japan. In comparison with women in other resource-rich countries, young women in Japan have a dismally low screening rate for cervical cancer. Our preliminary research has shown that 20-year-old women in Japan usually ask their mothers for advice regarding their initial cervical cancer screening. The objective of our current research is to determine the social factors among mothers in Japan that are causing them to give advice to their daughters regarding the HPV vaccine and cervical cancer screening.
    The survey's targets were mothers who had 20-year-old daughters. We recruited respondents from the roster of a commercial internet survey panel. We analyzed for correlations between a mother's knowledge concerning cervical cancer, her recent cancer screening history, and the advice she gave to her daughter regarding cervical cancer screening.
    We obtained 618 valid answers to the survey. Compared with mothers who did not get screening, mothers who had cervical cancer screening had significantly more knowledge about cervical cancer and its screening (p &lt; 0.05). The daughters of mothers with recent screening had received HPV vaccination more often than those of mothers without recent screening (p = 0.018). Mothers with recent screening histories tended more often to encourage their daughters to have cervical cancer screening (p &lt; 0.05). When mothers were properly educated concerning cervical cancer and its screening, they were significantly more likely than before to recommend that their daughters have it (p &lt; 0.0001).
    In young Japanese women, given the important role their mothers have in their lives, it is probable that we could improve their cervical cancer screening rate significantly by giving their mothers better medical information, and a chance to experience cervical cancer screening for themselves.

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  • 出生年度によって大きく異なるHPVワクチン接種率がもたらす将来の子宮頸がんリスクの出生年度による差異

    八木 麻未, 上田 豊, 田中 佑典, 高田 友美, 寺井 義人, 角 俊幸, 万代 昌紀, 中井 英勝, 斉藤 淳子, 佐藤 美紀子, 宮城 悦子, 榎本 隆之, 木村 正

    日本癌学会総会記事   75回   P - 3374   2016年10月

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    記述言語:英語   出版者・発行元:(一社)日本癌学会  

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  • Development of an efficient strategy to improve HPV immunization coverage in Japan 査読

    Asami Yagi, Yutaka Ueda, Tomomi Egawa-Takata, Yusuke Tanaka, Akiko Morimoto, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Risa Kudoh, Masayuki Sekine, Takayuki Enomoto, Kei Hirai, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    BMC PUBLIC HEALTH   16 ( 1 )   1013   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: In Japan, new HPV immunizations have dropped dramatically after repeated adverse media reports and a June 2013 temporary suspension of the government's recommendation for the vaccine. The aim of the present study was to develop an efficient strategy to improve HPV immunization coverage across Japan.
    Methods: We conducted an internet survey in Japan of mothers of 12-16 year-old girls who were unvaccinated as of May, 2015. The goal was to gather behavioral information from the mothers to develop a strategy for improving Japanese HPV immunization coverage.
    Results: Valid survey answers were obtained from 2060 mothers. The survey found that a hypothetical restart of a governmental recommendation for the vaccine would induce 4.1 % of all the mothers surveyed to be more likely to encourage vaccination of their daughters, without any other preconditions. This initial result would be followed by a moderate spread of vaccinations to these daughters' close friends and acquaintances, hypothetically resulting in a total vaccination rate of 21.0 % of the targeted age-eligible girls. As a second critical step for improving vaccinations, an educational information sheet integrating the concepts of behavioral economics for changing behaviors was found to be significantly effective for persuading mothers with poorer decision-making facilities, who would otherwise prefer to wait to first see the vaccination of other girls of the same age as their daughter.
    Conclusions: Following what we foresee as the inevitable restart of the Japanese government's recommendation for receiving the HPV vaccine, we expect to first see vaccinations occurring in a very small group of girls, the daughters of the most willing mothers, which will be roughly 4 % of those eligible for government paid vaccinations. This will be followed by the spread of vaccinations outward through these girls' circle of friends and acquaintances, and, finally, to the daughters of the most skeptical mothers, those who would await the return of new vaccine safety results from a large group of similarly-aged girls. As a critical step in improving HPV vaccine coverage in Japan, an educational information sheet that integrates the concepts of behavioral economics for changing behaviors can be employed to persuade mothers with poor decision-making facilities.

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  • Case with pyoderma gangrenosum abruptly emerging around the wound of cesarean section for placenta previa with placenta accrete 査読

    Taro Nonaka, Kunihiko Yoshida, Masayuki Yamaguchi, Atsuko Aizawa, Hiroshi Fujiwara, Takayuki Enomoto, Koichi Takakuwa

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   42 ( 9 )   1190 - 1193   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    A 39-year-old woman underwent emergency cesarean section (CS) due to placenta previa totalis with massive bleeding. Two major problems emerged in this patient after CS was carried out. One was partial retention of the placenta due to placenta accreta. Another major and more serious problem was pyoderma gangrenosum (PG) widely appearing at the skin of the abdomen around the CS wound. Conservative treatment was performed for the retained placenta, and it had completely disappeared by 76 days after the CS. The diagnosis of PG was promptly made in consultation with a plastic surgeon and a dermatologist when a wide ulcer emerged around the CS wound, and high-dose prednisolone was administered as treatment. At 90 days following the CS, near-complete epithelialization was achieved. This extremely rare case reflects the importance of rapid diagnosis and treatment of PG.

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  • Randomized Phase III Trial of Irinotecan Plus Cisplatin Compared With Paclitaxel Plus Carboplatin As First-Line Chemotherapy for Ovarian Clear Cell Carcinoma: JGOG3017/GCIG Trial 査読

    Toru Sugiyama, Aikou Okamoto, Takayuki Enomoto, Tetsutaro Hamano, Eriko Aotani, Yasuhisa Terao, Nao Suzuki, Mikio Mikami, Nobuo Yaegashi, Kiyoko Kato, Hiroyuki Yoshikawa, Yoshihito Yokoyama, Hiroshi Tanabe, Koji Nishino, Hiroyuki Nomura, Jae-Weon Kim, Byoung-Gie Kim, Sandro Pignata, Jerome Alexandre, John Green, Seiji Isonishi, Fumitoshi Terauchi, Keiichi Fujiwara, Daisuke Aoki

    JOURNAL OF CLINICAL ONCOLOGY   34 ( 24 )   2881 - +   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER SOC CLINICAL ONCOLOGY  

    Purpose
    Clear cell carcinoma (CCC) is a rare histologic subtype that demonstrates poor outcomes in epithelial ovarian cancer. The Japanese Gynecologic Oncology Group conducted the first randomized phase III, CCC-specific clinical trial that compared irinotecan and cisplatin (CPT-P) with paclitaxel plus carboplatin (TC) in patients with CCC.
    Patients and Methods
    Six hundred sixty-seven patients with stage I to IV CCC of the ovary were randomly assigned to receive irinotecan 60 mg/m(2) on days 1, 8, and 15 plus cisplatin 60 mg/m2 on day 1 (CPT-P group) every 4 weeks for six cycles or paclitaxel 175 mg/m2 plus carboplatin area under the curve 6.0mg/mL/min on day 1 every 3 weeks for six cycles (TC group). The primary end point was progression free survival. Secondary end points were overall survival, overall response rate, and adverse events.
    Results
    Six hundred nineteen patients were clinically and pathologically eligible for evaluation. With a median follow-up of 44.3 months, 2-year progression-free survival rates were 73.0% in the CPT-P group and 77.6% in TC group (hazard ratio, 1.17; 95% CI, 0.87 to 1.58; P = .85). Two-year overall survival rates were 85.5% with CPT-P and 87.4% with TC (hazard ratio, 1.13; 95% CI, 0.80 to 1.61; one-sided P = .76). Grade 3/4 anorexia, diarrhea, nausea, vomiting, and febrile neutropenia occurred more frequently with CPT-P, whereas grade 3/4 leukopenia, neutropenia, thrombocytopenia, peripheral sensory neuropathy, and joint pain occurred more frequently with TC.
    Conclusion
    No significant survival benefit was found for CPT- P. Both regimens were well tolerated, but the toxicity profiles differed significantly. Treatment with existing anticancer agents has limitations to improving the prognosis of CCC. (C) 2016 by American Society of Clinical Oncology

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  • 非認定研修施設での技術認定医受験 地方での取り組み

    古俣 大, 磯部 真倫, 風間 絵里菜, 松本 賢典, 横田 有紀, 南川 高廣, 高柳 健史, 加勢 宏明, 浅野 堅策, 五十嵐 裕一, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   316 - 316   2016年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 腹腔鏡下に治療した卵巣Sertoli-Leydig cell tumorの2症例

    山口 真奈子, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   261 - 261   2016年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 癌性腹膜炎との鑑別を要した結核性腹膜炎の一例

    安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   335 - 335   2016年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • Association of Low-Dose Aspirin and Survival of Women With Endometrial Cancer 査読

    Koji Matsuo, Sigita S. Cahoon, Kosuke Yoshihara, Masako Shida, Mamoru Kakuda, Sosuke Adachi, Aida Moeini, Hiroko Machida, Jocelyn Garcia-Sayre, Yutaka Ueda, Takayuki Enomoto, Mikio Mikami, Lynda D. Roman, Anil K. Sood

    OBSTETRICS AND GYNECOLOGY   128 ( 1 )   127 - 137   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    OBJECTIVE: To examine the survival outcomes in women with endometrial cancer who were taking low-dose aspirin (81-100 mg/d).
    METHODS: A multicenter retrospective study was conducted examining patients with stage I-IV endometrial cancer who underwent hysterectomy-based surgical staging between January 2000 and December 2013 (N=1,687). Patient demographics, medical comorbidities, medication types, tumor characteristics, and treatment patterns were correlated to survival outcomes. A Cox proportional hazard regression model was used to estimate adjusted hazard ratio for disease-free and disease-specific overall survival.
    RESULTS: One hundred fifty-eight patients (9.4%, 95% confidence interval [CI] 8.8-11.9) were taking low-dose aspirin. Median follow-up time for the study cohort was 31.5 months. One hundred twenty-seven patients (7.5%) died of endometrial cancer. Low-dose aspirin use was significantly correlated with concurrent obesity, hypertension, diabetes mellitus, and hypercholesterolemia (all P&lt;.001). Low-dose aspirin users were more likely to take other antihypertensive, antiglycemic, and anticholesterol agents (all P&lt;.05). Low-dose aspirin use was not associated with histologic subtype, tumor grade, nodal metastasis, or cancer stage (all P&gt;.05). On multivariable analysis, low-dose aspirin use remained an independent prognostic factor associated with an improved 5-year disease-free survival rate (90.6% compared with 80.9%, adjusted hazard ratio 0.46, 95% CI 0.25-0.86, P=.014) and disease-specific overall survival rate (96.4% compared with 87.3%, adjusted hazard ratio 0.23, 95% CI 0.08-0.64, P=.005). The increased survival effect noted with low-dose aspirin use was greatest in patients whose age was younger than 60 years (5-year disease-free survival rates, 93.9% compared with 84.0%, P=.013), body mass index was 30 or greater (92.2% compared with 81.4%, P=.027), who had type I cancer (96.5% compared with 88.6%, P=.029), and who received postoperative whole pelvic radiotherapy (88.2% compared with 61.5%, P=.014). These four factors remained significant for disease-specific overall survival (all P&lt;.05).
    CONCLUSION: Our results suggest that low-dose aspirin use is associated with improved survival outcomes in women with endometrial cancer, especially in those who are young, obese, with low-grade disease, and who receive postoperative radiotherapy.

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  • Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma. 査読

    Matsuo K, Takazawa Y, Ross MS, Elishaev E, Podzielinski I, Yunokawa M, Sheridan TB, Bush SH, Klobocista MM, Blake EA, Takano T, Matsuzaki S, Baba T, Satoh S, Shida M, Nishikawa T, Ikeda Y, Adachi S, Yokoyama T, Takekuma M, Fujiwara K, Hazama Y, Kadogami D, Moffitt MN, Takeuchi S, Nishimura M, Iwasaki K, Ushioda N, Johnson MS, Yoshida M, Hakam A, Li SW, Richmond AM, Machida H, Mhawech-Fauceglia P, Ueda Y, Yoshino K, Yamaguchi K, Oishi T, Kajiwara H, Hasegawa K, Yasuda M, Kawana K, Suda K, Miyake TM, Moriya T, Yuba Y, Morgan T, Fukagawa T, Wakatsuki A, Sugiyama T, Pejovic T, Nagano T, Shimoya K, Andoh M, Shiki Y, Enomoto T, Sasaki T, Fujiwara K, Mikami M, Shimada M, Konishi I, Kimura T, Post MD, Shahzad MM, Im DD, Yoshida H, Omatsu K, Ueland FR, Kelley JL, Karabakhtsian RG, Roman LD

    Annals of oncology : official journal of the European Society for Medical Oncology   27 ( 7 )   1257 - 1266   2016年7月

  • 腹腔鏡下に治療した卵巣Sertoli-Leydig cell tumorの2症例

    山口 真奈子, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   111 ( 1 )   41 - 41   2016年7月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • Single-dose intra-arterial neoadjuvant chemotherapy while waiting for radical hysterectomy for stage IB-IIB cervical cancer. 査読 国際誌

    Yoshino K, Hosoi A, Osuga K, Enomoto T, Ueda Y, Sawada K, Mabuchi S, Kobayashi E, Matsuo K, Kimura T

    Molecular and clinical oncology   4 ( 6 )   1068 - 1072   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3892/mco.2016.846

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  • Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes 査読

    Ryusuke Murakami, Noriomi Matsumura, Masaki Mandai, Kosuke Yoshihara, Hiroshi Tanabe, Hidekatsu Nakai, Koji Yamanoi, Kaoru Abiko, Yumiko Yoshioka, Junzo Hamanishi, Ken Yamaguchi, Tsukasa Baba, Masafumi Koshiyama, Takayuki Enomoto, Aikou Okamoto, Susan K. Murphy, Seiichi Mori, Yoshiki Mikami, Sachiko Minamiguchi, Ikuo Konishi

    AMERICAN JOURNAL OF PATHOLOGY   186 ( 5 )   1103 - 1113   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Recently, The Cancer Genome Atlas data revealed four molecular subtypes of high-grade serous ovarian carcinoma (HGSOC) exhibiting distinct prognoses. We developed four novel HGSOC histopathological subtypes by focusing on tumor microenvironment: mesenchymal transition, defined by a remarkable desmoplastic reaction; immune reactive by lymphocytes infiltrating the tumor; solid and proliferative by a solid growth pattern; and papilloglandular by a papillary architecture. Unsupervised hierarchical clustering revealed four clusters correlated with histopathological subtypes in both Kyoto and Niigata HGSOC transcriptome data sets (P &lt; 0.001). Gene set enrichment analysis revealed pathways enriched in our histopathological classification significantly overlapped with the four molecular subtypes: mesenchymal, immunoreactive, proliferative, and differentiated (P &lt; 0.0001, respectively). In 132 HGSOC cases, progression-free survival and overall survival were best in the immune reactive, whereas overall survival was worst in the mesenchymal transition (P &lt; 0.001, respectively), findings reproduced in 89 validation cases (P &lt; 0.05, respectively). The CLOVAR_MES_UP single-sample gene set enrichment analysis scores representing the mesenchymal molecular subtype were higher in paclitaxel responders than nonresponders (P = 0.002) in the GSE15622 data set. Taxane-containing regimens improved survival of cases with high MES_UP scores compared with nontaxane regimens (P &lt; 0.001) in the GSE9891 data set. Our novel histopathological classification of HGSOC correlates with distinct prognostic transcriptome subtypes. The mesenchymal transition subtype might be particularly sensitive to taxane.

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  • A phase II study of postoperative concurrent carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy followed by consolidation chemotherapy in surgically treated cervical cancer patients with positive pelvic lymph nodes 査読

    Seiji Mabuchi, Fumiaki Isohashi, Takeshi Yokoi, Masahiko Takemura, Kiyoshi Yoshino, Yasuhiko Shiki, Kimihiko Ito, Takayuki Enomoto, Kazuhiko Ogawa, Tadashi Kimura

    GYNECOLOGIC ONCOLOGY   141 ( 2 )   240 - 246   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Objectives. A phase II study was conducted to evaluate the efficacy and toxicity of carboplatin plus paclitaxel (TC)-based postoperative concurrent chemoradiotherapy (CCRT) followed by TC-based consolidation chemotherapy in surgically-treated early-stage cervical cancer patients.
    Methods. Women with surgically-treated early-stage cervical cancer with positive pelvic lymph nodes were eligible for this study. The patients were postoperatively treated with pelvic intensity modulated radiotherapy (50.4 Gy) and concurrent weekly carboplatin (AUC: 2) and paclitaxel (35 mg/m(2)) (TC-based CCRT). Three cycles of consolidation chemotherapy involving carboplatin (AUC: 5) and paclitaxel (175 mg/m2) were administered after TC-based CCRT.
    Results. Thirty-one patients were enrolled and treated. Overall, the treatment was well tolerated, and 26 patients (83.9%) completed the planned TC-based CCRT. The most frequently observed acute grade 3/4 hematological toxicities were leukopenia and neutropenia, and diarrhea was the most common acute grade 3/4 non hematological toxicity. After a median follow-up period of 36.5 months,. 2 patients (6.5%) had developed recurrent disease. The patients' estimated 3-year progression-free survival (PFS) and overall survival (OS) rates were 88.5% and 93.8%, respectively. In comparisons with historical control groups, TC-based CCRT followed by TC-based consolidation chemotherapy was found to be significantly superior to CCRT involving a single platinum agent in terms of PFS (p = 0.026) and significantly superior to extended-field radiotherapy in terms of both PFS (p = 0.0004) and OS (p = 0.034).
    Conclusions. In women with surgically treated early-stage cervical cancer, pelvic TC-based CCRT followed by TC-based consolidation chemotherapy is feasible and highly effective. Future randomized trials are needed to verify the efficacy of this regimen. (C) 2016 Elsevier Inc. All rights reserved.

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  • Japanese crisis of HPV vaccination 査読

    Masayuki Sekine, Risa Kudo, Sosuke Adachi, Manako Yamaguchi, Yutaka Ueda, Tomomi Takata, Akiko Morimoto, Yusuke Tanaka, Asami Yagi, Etsuko Miyagi, Takayuki Enomoto

    Int J Pathol Clin Res   2 ( 039s )   2016年5月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus. 査読 国際誌

    Hirofumi Nakaoka, Aishwarya Gurumurthy, Takahide Hayano, Somayeh Ahmadloo, Waleed H Omer, Kosuke Yoshihara, Akihito Yamamoto, Keisuke Kurose, Takayuki Enomoto, Shigeo Akira, Kazuyoshi Hosomichi, Ituro Inoue

    PLoS genetics   12 ( 4 )   e1005893   2016年4月

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    記述言語:英語  

    Genome-wide association studies (GWASs) have discovered numerous single nucleotide polymorphisms (SNPs) associated with human complex disorders. However, functional characterization of the disease-associated SNPs remains a formidable challenge. Here we explored regulatory mechanism of a SNP on chromosome 9p21 associated with endometriosis by leveraging "allele-specific" functional genomic approaches. By re-sequencing 1.29 Mb of 9p21 region and scrutinizing DNase-seq data from the ENCODE project, we prioritized rs17761446 as a candidate functional variant that was in perfect linkage disequilibrium with the original GWAS SNP (rs10965235) and located on DNase I hypersensitive site. Chromosome conformation capture followed by high-throughput sequencing revealed that the protective G allele of rs17761446 exerted stronger chromatin interaction with ANRIL promoter. We demonstrated that the protective allele exhibited preferential binding affinities to TCF7L2 and EP300 by bioinformatics and chromatin immunoprecipitation (ChIP) analyses. ChIP assays for histone H3 lysine 27 acetylation and RNA polymerase II reinforced the enhancer activity of the SNP site. The allele specific expression analysis for eutopic endometrial tissues and endometrial carcinoma cell lines showed that rs17761446 was a cis-regulatory variant where G allele was associated with increased ANRIL expression. Our work illuminates the allelic imbalances in a series of transcriptional regulation from factor binding to gene expression mediated by chromatin interaction underlie the molecular mechanism of 9p21 endometriosis risk locus. Functional genomics on common disease will unlock functional aspect of genotype-phenotype correlations in the post-GWAS stage.

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  • Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus 査読

    Hirofumi Nakaoka, Aishwarya Gurumurthy, Takahide Hayano, Somayeh Ahmadloo, Waleed H. Omer, Kosuke Yoshihara, Akihito Yamamoto, Keisuke Kurose, Takayuki Enomoto, Shigeo Akira, Kazuyoshi Hosomichi, Ituro Inoue

    PLOS GENETICS   12 ( 4 )   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Genome-wide association studies (GWASs) have discovered numerous single nucleotide polymorphisms (SNPs) associated with human complex disorders. However, functional characterization of the disease-associated SNPs remains a formidable challenge. Here we explored regulatory mechanism of a SNP on chromosome 9p21 associated with endometriosis by leveraging "allele-specific" functional genomic approaches. By re-sequencing 1.29 Mb of 9p21 region and scrutinizing DNase-seq data from the ENCODE project, we prioritized rs17761446 as a candidate functional variant that was in perfect linkage disequilibrium with the original GWAS SNP (rs10965235) and located on DNase I hypersensitive site. Chromosome conformation capture followed by high-throughput sequencing revealed that the protective G allele of rs17761446 exerted stronger chromatin interaction with ANRIL promoter. We demonstrated that the protective allele exhibited preferential binding affinities to TCF7L2 and EP300 by bioinformatics and chromatin immunoprecipitation (ChIP) analyses. ChIP assays for histone H3 lysine 27 acetylation and RNA polymerase II reinforced the enhancer activity of the SNP site. The allele specific expression analysis for eutopic endometrial tissues and endometrial carcinoma cell lines showed that rs17761446 was a cis-regulatory variant where G allele was associated with increased ANRIL expression. Our work illuminates the allelic imbalances in a series of transcriptional regulation from factor binding to gene expression mediated by chromatin interaction underlie the molecular mechanism of 9p21 endometriosis risk locus. Functional genomics on common disease will unlock functional aspect of genotype-phenotype correlations in the post-GWAS stage.

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  • The utility of anatomic diagnosis for identifying femoral nerve palsy following gynecologic surgery 査読

    Tatsunori Watanabe, Masayuki Sekine, Takayuki Enomoto, Hiroshi Baba

    JOURNAL OF ANESTHESIA   30 ( 2 )   317 - 319   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    We describe a case in which an anatomic diagnosis was useful for diagnosing and estimating the cause of femoral nerve palsy following gynecologic surgery. A 49-year-old female received general and epidural anesthesia for radical ovarian cancer surgery. Although injection pain was noted in the left medial shin with 1 % mepivacaine administered as a test dose, the catheter was left indwelling because it improved her symptoms. The surgery, which lasted 195 min, was performed in the lithotomy position, and a self-retained retractor was used to gain a good surgical field. Postoperatively, the patient complained of difficulty in stretching her knee joint and left lower limb paresthesia that did not improve after stopping continuous epidural administration. A spinal cord injury related to epidural anesthesia was suspected because the sites of sensory impairment and epidural injection pain were the same; however, the patient had greater weakness of the quadriceps muscle than the iliopsoas, and no other muscle weakness was observed. These findings and previous reports suggest that her femoral nerve palsy was caused by compression of the inguinal ligament from the self-retaining retractor and lithotomy position. Twenty months after surgery, her muscle strength had fully recovered.

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  • Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas 査読

    Kosuke Hiramatsu, Kiyoshi Yoshino, Satoshi Serada, Kosuke Yoshihara, Yumiko Hori, Minoru Fujimoto, Shinya Matsuzaki, Tomomi Egawa-Takata, Eiji Kobayashi, Yutaka Ueda, Eiichi Morii, Takayuki Enomoto, Tetsuji Naka, Tadashi Kimura

    BRITISH JOURNAL OF CANCER   114 ( 5 )   554 - 561   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Background: Ovarian and endometrial high-grade serous carcinomas (HGSCs) have similar clinical and pathological characteristics; however, exhaustive protein expression profiling of these cancers has yet to be reported.
    Methods: We performed protein expression profiling on 14 cases of HGSCs (7 ovarian and 7 endometrial) and 18 endometrioid carcinomas (9 ovarian and 9 endometrial) using iTRAQ-based exhaustive and quantitative protein analysis.
    Results: We identified 828 tumour-expressed proteins and evaluated the statistical similarity of protein expression profiles between ovarian and endometrial HGSCs using unsupervised hierarchical cluster analysis (P&lt;0.01). Using 45 statistically highly expressed proteins in HGSCs, protein ontology analysis detected two enriched terms and proteins composing each term: IMP2 and MCM2. Immunohistochemical analyses confirmed the higher expression of IMP2 and MCM2 in ovarian and endometrial HGSCs as well as in tubal and peritoneal HGSCs than in endometrioid carcinomas (P&lt;0.01). The knockdown of either IMP2 or MCM2 by siRNA interference significantly decreased the proliferation rate of ovarian HGSC cell line (P&lt;0.01).
    Conclusions: We demonstrated the statistical similarity of the protein expression profiles of ovarian and endometrial HGSC beyond the organs. We suggest that increased IMP2 and MCM2 expression may underlie some of the rapid HGSC growth observed clinically.

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  • Human papillomavirus vaccination of the daughters of obstetricians and gynecologists in Japan 査読

    Tomomi Egawa-Takata, Yutaka Ueda, Akiko Morimoto, Yusuke Tanaka, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Masayuki Sekine, Takayuki Enomoto, Tadashi Kimura

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   21 ( 1 )   53 - 58   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    Most adolescents in Japan have recently been refraining from receiving the human papillomavirus (HPV) vaccine, following media reports of adverse medical events surrounding the vaccination and suspension of the Japanese governmental recommendation. We have previously reported that HPV vaccination of young girls is heavily influenced by guidance from their physicians concerning the vaccine and by the knowledge and attitude of the girls' mothers towards cervical cancer. However, it has been unclear as to how the obstetricians and gynecologists were themselves affected by the negative media reports.
    A questionnaire, including questions about their working status, attitudes toward HPV vaccination and about cervical cancer, and the HPV vaccination status of their daughters, was posted to obstetricians and gynecologists.
    None of the daughters of the responding obstetrician and gynecologists received the HPV vaccination after the announced suspension of the governmental recommendation for the vaccine. The number who received the HPV vaccine in the 6th to 9th grade in 2014 was significantly lower than those in 2012 (p = 0.012). However, 64.7 % of the responders whose daughters were eligible and in the 6th to 12th grade still intended to vaccinate their daughters in the future. Of the responders, 65 % also intended to recommend vaccination to their teenage patients.
    Our study revealed that obstetricians and gynecologists, like the general population, were negatively influenced by media reports of the adverse effect of the HPV vaccine and the suspension of the governmental recommendation. However, their intention to vaccinate their daughters was much higher than that of the general population. Restart of the governmental recommendation for HPV vaccines and better education about the HPV vaccine, including its adverse effects, and about cervical cancer and cervical cancer screening, are strongly recommended, for both the general public and for doctors, for improved prevention of cervical cancer.

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  • Early metabolic change in F-18-FDG-PET by measuring the single largest lesion predicts chemotherapeutic effects and patients' survival: PEACH study 査読

    Yusuke Tanaka, Yutaka Ueda, Tomomi Egawa-Takata, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Takayuki Enomoto, Mitsuaki Tatsumi, Tadashi Kimura

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   77 ( 1 )   121 - 126   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The objective of this study was to investigate the predictive value of F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) for early assessment of tumor response to chemotherapy and for patient survival in gynecologic malignancies.
    We performed CT and FDG-PET scans before initiation of chemotherapy to determine baseline conditions. PET scan was repeated after the first cycle of chemotherapy. The tumor response was later evaluated by CT scans after three cycles of chemotherapy, using RECIST. The PET response was analyzed in terms of the difference in SUVmax for FDG of the patient's largest lesion between the baseline scan and after the first cycle of chemotherapy. The metabolic response for the tumor was defined as a 30 % reduction in its SUVmax.
    Eleven patients received platinum-based regimens, and 20 patients received non-platinum-based regimens. The mean progression-free survival (PFS) for the patients with a metabolic response was 13 months (range 5-29). In contrast, the mean PFS of the patients with no metabolic response was only 4.3 months (range 1-18). There was a statistically significant difference between the metabolic response and PFS (p = 0.002, Mann-Whitney U test). There was a strong correlation between the metabolic response and RECIST, regardless of the chemotherapy regimens used (platinum-based group, p = 0.006; non-platinum group, p = 0.046, Fisher's exact test). The metabolic change in SUVmax was clearly predictive of tumor response in 93.5 % of patients.
    Early FDG-PET assessment by measuring the single largest lesion is a very promising tool for rapidly predicting tumor responses and patient survival, regardless of the chemotherapy regimen.

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  • Association of NR3C1/Glucocorticoid Receptor gene SNP with azoospermia in Japanese men 査読

    Makoto Chihara, Kosuke Yoshihara, Tatsuya Ishiguro, Sosuke Adachi, Hiroyuki Okada, Katsunori Kashima, Takaaki Sato, Atsushi Tanaka, Kenichi Tanaka, Takayuki Enomoto

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   42 ( 1 )   59 - 66   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    AimThe molecular pathogenesis of non-obstructive azoospermia (NOA) is unclear. Our aim was to identify the genetic susceptibility for NOA in Japanese men by using a combination of transcriptome network analysis and SNP genotyping.
    Material and MethodsWe searched for candidate genes using RNA transcriptome network analysis of 2611 NOA-related genes that we had previously reported. We analyzed candidate genes for disease linkage with single nucleotide polymorphisms (SNP) in the genomes of 335 Japanese men with NOA and 410 healthy controls using SNP-specific real-time polymerase chain reaction TaqMan assays.
    ResultsThree candidate genes (NR3C1, YBX2, and BCL2) were identified by the transcriptome network analysis, each with three SNP. Allele frequency analysis of the nine SNP indicated a significantly higher frequency of the NR3C1 rs852977 G allele in NOA cases compared with controls (corrected P = 5.7e-15; odds ratio = 3.20; 95% confidence interval, 2.40-4.26). The other eight candidate polymorphisms showed no significant association.
    ConclusionThe NR3C1 rs852977 polymorphism is a potential marker for genetic susceptibility to NOA in Japanese men. Further studies are necessary to clarify the association between the NR3C1 polymorphism and alterations of glucocorticoid signaling pathway leading to male infertility.

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  • Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity 査読

    Tatsuya Ishiguro, Ai Sato, Hirokazu Ohata, Yoshinori Ikarashi, Ryou-u Takahashi, Takahiro Ochiya, Masayuki Yoshida, Hitoshi Tsuda, Takashi Onda, Tomoyasu Kato, Takahiro Kasamatsu, Takayuki Enomoto, Kenichi Tanaka, Hitoshi Nakagama, Koji Okamoto

    CANCER RESEARCH   76 ( 1 )   150 - 160   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER ASSOC CANCER RESEARCH  

    The establishment of cancer stem-like cell (CSC) culture systems may be instrumental in devising strategies to fight refractory cancers. Inhibition of the Rho kinase ROCK has been shown to favorably affect CSC spheroid cultures. In this study, we show how ROCK inhibition in human serous ovarian cancer (SOC) cells can help establish a CSC system, which illuminates cancer pathophysiology and its treatment in this setting. In the presence of a ROCK kinase inhibitor, spheroid cultures of SOC cells expressed characteristic CSC markers including ALDH1A1, CD133, and SOX2, along with differentiation and tumorigenic capabilities in mouse xenograft models of human SOC. High expression levels of ALDH, but not CD133, correlated with spheroid formation CSC marker expression and tumor forming capability. In clinical specimens of SOC, high levels of ALDH1A1 correlated with advanced stage and poor prognosis. Pharmacologic or genetic blockade of ALDH blocked cell proliferation and reduced expression of SOX2, the genetic ablation of which abolished spheroid formation, whereas SOX2 overexpression inhibited ALDH1A1 expression and blocked spheroid proliferation. Taken together, our findings illustrated a new method to culture human ovarian CSC, and they defined a reciprocal regulatory relationship between ALDH1A1 and SOX2, which impacts ovarian CSC proliferation and malignant progression. (C)2015 AACR.

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  • Novel kinase fusion transcripts found in endometrial cancer 査読

    Ryo Tamura, Kosuke Yoshihara, Kaoru Yamawaki, Kazuaki Suda, Tatsuya Ishiguro, Sosuke Adachi, Shujiro Okuda, Ituro Inoue, Roel G. W. Verhaak, Takayuki Enomoto

    SCIENTIFIC REPORTS   5   18657   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Recent advances in RNA-sequencing technology have enabled the discovery of gene fusion transcripts in the transcriptome of cancer cells. However, it remains difficult to differentiate the therapeutically targetable fusions from passenger events. We have analyzed RNA-sequencing data and DNA copy number data from 25 endometrial cancer cell lines to identify potential therapeutically targetable fusion transcripts, and have identified 124 high-confidence fusion transcripts, of which 69% are associated with gene amplifications. As targetable fusion candidates, we focused on three in-frame kinase fusion transcripts that retain a kinase domain (CPQ-PRKDC, CAPZA2-MET, and VGLL4-PRKG1). We detected only CPQ-PRKDC fusion transcript in three of 122 primary endometrial cancer tissues. Cell proliferation of the fusion-positive cell line was inhibited by knocking down the expression of wild-type PRKDC but not by blocking the CPQ-PRKDC fusion transcript expression. Quantitative real-time RT-PCR demonstrated that the expression of the CPQ-PRKDC fusion transcript was significantly lower than that of wild-type PRKDC, corresponding to a low transcript allele fraction of this fusion, based on RNA-sequencing read counts. In endometrial cancers, the CPQ-PRKDC fusion transcript may be a passenger aberration related to gene amplification. Our findings suggest that transcript allele fraction is a useful predictor to find bona-fide therapeutic-targetable fusion transcripts.

    DOI: 10.1038/srep18657

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  • Survey of Japanese mothers of daughters eligible for human papillomavirus vaccination on attitudes about media reports of adverse events and the suspension of governmental recommendation for vaccination 査読

    Tomomi Egawa-Takata, Yutaka Ueda, Akiko Morimoto, Kiyoshi Yoshino, Tadashi Kimura, Nobumichi Nishikawa, Masayuki Sekine, Yorihiko Horikoshi, Tetsu Takagi, Takayuki Enomoto

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   41 ( 12 )   1965 - 1971   2015年12月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Aim: Following media reports of adverse medical events surrounding human papillomavirus (HPV) vaccination and the suspension of Japanese governmental recommendation, most adolescents have refrained from receiving the vaccine. This represents a national critical event, because the incidence of cervical cancer in Japan continues to increase.
    Methods: We conducted an Internet survey to investigate why Japanese adolescent girls decline, continue or discontinue their HPV vaccination, how their mothers influence their decision, and the mothers' feelings about future HPV vaccination for their daughters. One thousand mothers with daughters 10-18 years of age were recruited for our questionnaire.
    Results: Our results suggest that acceptance of the HPV vaccine was determined predominantly by the mother's perceptions of risk versus benefits, rather than the daughter's wishes. The mothers' knowledge of the benefits of the prophylactic HPV vaccine and their attitude toward cervical cancer screening influenced their decision whether to allow their daughter to receive future vaccinations. The tenor of survey responses of those mothers who were anti-vaccine changed significantly to the positive in response to a proposed scenario where the governmental recommendation for the HPV vaccine was reinstated, whereas a hypothetical educational intervention sheet did not significantly change their attitude.
    Conclusions: Promotion of the HPV vaccine through comprehensive education for both mothers and daughters, not only on the vaccine itself, but also about cervical cancer and screening, is required for any successful program to prevent cervical cancer.

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  • 新潟大学とその関連病院における腹腔鏡手術教育の現況(その2)

    磯部 真倫, 榎本 隆之

    日本内視鏡外科学会雑誌   20 ( 7 )   OS64 - 1   2015年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内視鏡外科学会  

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  • 腹腔鏡下骨盤内リンパ節郭清のピットフォールとその対策 当科における骨盤内リンパ節郭清とその立ち上げ

    藤原 和子, 磯部 真倫, 榎本 隆之

    日本内視鏡外科学会雑誌   20 ( 7 )   WS30 - 3   2015年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内視鏡外科学会  

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  • 子宮頸部細胞診AGCからminimal deviation adenocarcinoma(MDA)との鑑別に苦慮したlobular endocervical glandular hyperplasia(LEGH)の一症例

    藤原 和子, 西野 幸治, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   110 ( 2 )   60 - 63   2015年12月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    症例は34歳女性で、3年前の検診にてLSIL、CIN Iのため管理されていたが、約2年前より通院を自己中断していた。子宮頸部細胞診にてAGCであったため紹介となった。子宮頸部細胞診では好塩基性に染色される子宮頸管腺粘液産生細胞集塊と黄色調粘液細胞を認めた。内診と経腟超音波所見では子宮付属器に異常所見を認めなかった。コルポスコピーでは、子宮頸部全体にW1、6時にW2、GOを認めCIN IIを疑う所見であった。子宮内膜細胞診は陰性であった。診断的子宮頸部円錐切除術を施行した。摘出物の病理組織所見では、周囲に小腺管を多数伴う拡張した頸管腺を多数認めるが細胞に異型は認めなかった。病変の広がりは縦10mm、間質浸潤5mm、断端は陰性であった。HIK1083免疫染色でほぼ全ての細胞が陽性であった。細胞に異型が乏しいこと、腺管がほぼ全てHIK1083陽性であることから分葉状子宮頸部腺過形成(LEGH)と診断した。断端陰性および病理診断より術後追加治療なく経過観察の方針とした。

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  • [Mesorectal Lymph Node Metastasis Arising from Rectal Invasion by an Ovarian Cancer--A Case Report]. 査読

    Mizuki T, Shimada Y, Yagi Y, Tajima Y, Nakano M, Nakano M, Tatsuda K, Ishikawa T, Sakata J, Kameyama H, Kobayashi T, Kosugi S, Koyama Y, Wakai T, Enomoto T

    Gan to kagaku ryoho. Cancer & chemotherapy   42 ( 12 )   2300 - 2302   2015年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 卵巣癌直腸浸潤により直腸間膜内リンパ節転移を来した1例

    水木 亨, 島田 能史, 八木 寛, 田島 陽介, 中野 麻恵, 中野 雅人, 辰田 久美子, 石川 卓, 坂田 純, 亀山 仁史, 小林 隆, 小杉 伸一, 小山 諭, 若井 俊文, 榎本 隆之

    癌と化学療法   42 ( 12 )   2300 - 2302   2015年11月

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    記述言語:日本語   出版者・発行元:(株)癌と化学療法社  

    症例は58歳、女性。腹部膨満を主訴に近医を受診し、その後当院産婦人科へ紹介された。胸腹骨盤部CT検査では、右卵巣腫大、多発肺転移、多発肝転移、腹膜播種を指摘され、さらにダグラス窩の腹膜播種は直腸への浸潤が疑われた。卵巣癌Stage IVに対して術前化学療法(paclitaxel+carboplatin療法)を3コース行った。その後、腹腔内の腫瘍減量手術(子宮・両側付属器摘出、大網部分切除、腹膜播種切除、Hartmann手術)を施行した。直腸間膜内に多発するリンパ節腫大を認めたため、下腸間膜動脈根部までのリンパ節郭清を行った。術後の病理組織学的診断では、右卵巣漿液性腺癌の診断となった。また、傍直腸リンパ節にも卵巣癌の転移が認められた。術後は化学療法を再開し、現在加療中である。卵巣癌の直腸浸潤では、直腸切除と直腸所属リンパ節郭清を行うことで卵巣癌の腫瘍減量手術に寄与する可能性が示唆された。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00296&link_issn=&doc_id=20151224470285&doc_link_id=%2Fab8gtkrc%2F2015%2F004212%2F285%2F2300-2302%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2015%2F004212%2F285%2F2300-2302%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody 査読

    Kosuke Hiramatsu, Satoshi Serada, Kouji Kobiyama, Satoshi Nakagawa, Akiko Morimoto, Shinya Matsuzaki, Yutaka Ueda, Minoru Fujimoto, Kiyoshi Yoshino, Ken J. Ishii, Takayuki Enomoto, Tadashi Kimura, Tetsuji Naka

    CANCER SCIENCE   106 ( 10 )   1474 - 1478   2015年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Numerous monoclonal antibodies (mAb) targeting tumor antigens have recently been developed. Antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) via effector cells such as tumor-infiltrating natural killer (NK) cells and macrophages are often involved in mediating the antitumor activity of mAb. CpG oligodeoxynucleotides (ODN) have a potent antitumor activity and are considered to increase tumor infiltration of NK cells and macrophages. Our group previously reported significant antitumor activity of anti-bone marrow stromal antigen 2 (BST2) mAb against BST2-positive endometrial cancer cells through ADCC. In this study, we evaluated the synergistic antitumor activity of combination therapy with anti-BST-2 mAb and CpG ODN using SCID mice and elucidated the mechanisms underlying this activity. Anti-BST2 mAb and CpG ODN monotherapy had a significant dose-dependent antitumor activity (P=0.0135 and P=0.0196, respectively). Combination therapy with anti-BST2 mAb and CpG ODN had a significant antitumor activity in SCID mice (P&lt;0.01), but not in NOG mice. FACS analysis revealed significantly increased numbers of NK cells and macrophages in tumors treated with a combination of anti-BST2 mAb and CpG ODN and with CpG ODN alone in SCID mice (P&lt;0.05 and P&lt;0.01, respectively). These results suggested that the combination therapy with anti-BST2 mAb and CpG ODN has a significant antitumor activity and induces tumor infiltration of NK cells and macrophages. Combination therapy with CpG ODN and anti-BST2 mAb or other antitumor mAb depending on ADCC may represent a new treatment option for cancer.

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  • Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma 査読

    Koji Matsuo, Kosei Hasegawa, Kiyoshi Yoshino, Ryusuke Murakami, Takeshi Hisamatsu, Rebecca L. Stone, Rebecca A. Previs, Jean M. Hansen, Yuji Ikeda, Akiko Miyara, Kosuke Hiramatsu, Takayuki Enomoto, Keiichi Fujiwara, Noriomi Matsumura, Ikuo Konishi, Lynda D. Roman, Hani Gabra, Christina Fotopoulou, Anil K. Sood

    EUROPEAN JOURNAL OF CANCER   51 ( 14 )   1978 - 1988   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Background: We compared survival outcomes and risk of venous thromboembolism (VTE) among patients with advanced and early-stage ovarian clear cell carcinoma (OCCC) and serous ovarian carcinoma (SOC), as well as potential links with interleukin-6 (IL-6) levels.
    Methods: A multicenter case-control study was conducted in 370 patients with OCCC and 938 with SOC. In a subset of 200 cases, pretreatment plasma IL-6 levels were examined.
    Findings: Patients with advanced OCCC had the highest 2-year cumulative VTE rates (advanced OCCC 43.1%, advanced SOC 16.2%, early-stage OCCC 11.9% and early-stage SOC 6.4%, P &lt; 0.0001) and the highest median levels of IL-6 (advanced OCCC 17.8 pg/mL, advanced SOC 9.0 pg/mL, early-stage OCCC 4.2 pg/mL and early-stage SOC 5.0 pg/mL, P = 0.006). Advanced OCCC (hazard ratio [HR] 3.38, P &lt; 0.0001), thrombocytosis (HR 1.42, P = 0.032) and elevated IL-6 (HR 8.90, P = 0.046) were independent predictors of VTE. In multivariate analysis, patients with advanced OCCC had significantly poorer 5-year progression-free and overall survival rates than those with advanced SOC (P &lt; 0.01), and thrombocytosis was an independent predictor of decreased survival outcomes (P &lt; 0.01). Elevated IL-6 levels led to poorer 2-year progression-free survival rates in patients with OCCC (50% versus 87.5%, HR 4.89, P = 0.016) than in those with SOC (24.9% versus 40.8%, HR 1.40, P = 0.07).
    Interpretation: Advanced OCCC is associated with an increased incidence of VTE and decreased survival outcomes, which has major implications for clinical management of OCCC. (C) 2015 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.ejca.2015.07.012

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  • 卵巣 卵巣がん治療の個別化に向けて PETの新しい活用法による化学療法奏効性予測のための前方視的研究:PEACH study

    田中 佑典, 上田 豊, 高田 友美, 松崎 慎哉, 小林 栄仁, 澤田 健二郎, 冨松 拓治, 吉野 潔, 榎本 隆之, 巽 光朗, 木村 正

    日本癌治療学会誌   50 ( 3 )   176 - 176   2015年9月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • 当科における未熟奇形腫の臨床的検討

    明石 英彦, 西川 伸道, 安達 聡介, 吉原 弘佑, 磯部 真倫, 西野 幸治, 関根 正幸, 榎本 隆之

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   63回   94 - 94   2015年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • Differential diagnosis of uterine smooth muscle tumors using diffusion-weighted imaging: correlations with the apparent diffusion coefficient and cell density 査読

    Akiko Tasaki, Mina O. Asatani, Hajime Umezu, Katsunori Kashima, Takayuki Enomoto, Norihiko Yoshimura, Hidefumi Aoyama

    ABDOMINAL IMAGING   40 ( 6 )   1742 - 1752   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The purpose of this study is to investigate the utility of the apparent diffusion coefficient (ADC) in differentiating benign and malignant uterine smooth muscle tumors classified by signal intensity (SI) on T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI), and to determine the correlation between ADC and tumor cell density. This retrospective study reviewed 168 lesions in 134 cases with pathologically confirmed uterine smooth muscle tumors, including 6 leiomyosarcomas and 3 smooth muscle tumors of uncertain malignant potential, and preoperative magnetic resonance imaging examinations performed between October 2009 and November 2012. T2WI and DWI were also performed for each subject. Tumors were then classified according to SI on T2WI and DWI relative to myometrial SI. The correlation between ADC and tumor cell density was also determined. In Group 1 (high on both T2WI/DWI), mean ADC was significantly lower for leiomyosarcoma (0.91 x 10(-3) mm(2)/s) than for leiomyoma (1.30 x 10(-3) mm(2)/s; p &lt; 0.05) and mean cell density significantly higher for leiomyosarcoma (42.9%) than for leiomyoma (22.4%; p &lt; 0.05). A strong negative correlation was seen between ADC and tumor cell density in Group 1 (Spearman, R = -0.72; p &lt; 0.05). ADC may help to differentiate benign from malignant uterine smooth muscle tumors, particularly tumors with high SI on T2WI and DWI.

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  • 腹腔鏡補助下にDavydov法による造腟術を行ったMayer-Rokitansky-Kuester-Hauser症候群の四例

    西野 幸治, 井上 清香, 安達 聡介, 磯部 真倫, 西川 伸道, 芹川 武大, 関根 正幸, 加嶋 克則, 榎本 隆之, 山岸 葉子

    新潟産科婦人科学会会誌   110 ( 1 )   30 - 30   2015年8月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination 査読

    Akiko Morimoto, Yutaka Ueda, Tomomi Egawa-Takata, Asami Yagi, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hideharu Kanzaki, Hidekatsu Nakai, Masaki Mandai, Kiyoshi Yoshino, Masami Fujita, Tadashi Kimura, Junko Saito, Tomotaka Sobue, Nobumichi Nishikawa, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   20 ( 3 )   549 - 555   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    Administration of the human papillomavirus (HPV) vaccine decreased dramatically in Japan after extensive news of adverse vaccine events and suspension of the governmental recommendation for the vaccine. In this study, we investigated the knowledge and acceptance of vaccinated adolescents concerning cervical cancer, cancer screening and the HPV vaccine. Furthermore, we analyzed whether and by how much the news affected acceptance of the vaccination.
    This study was conducted as a part of Osaka Clinical resEArch of HPV vacciNe (OCEAN) study. A questionnaire was distributed to 2,777 study registrants.
    The response rate was 38 %. The recognition rate of the news of the vaccine's adverse events was 80 %; it was 68 % for awareness of the government's announcement of the suspension of its recommendation for the vaccine. Among those who had a chance to hear or see the negative news during their vaccination period, 46 (60 %) continued vaccination while knowing of the news, 22 (29 %) discontinued vaccination, and 9 (11 %) continued vaccination without an awareness of the news. Reports of the vaccine's adverse events were the main reason for not continuing the vaccination series. Those who consulted doctors after hearing the adverse news were significantly more likely to continue their vaccinations than those who did not.
    Our results should help in understanding the need for a strong promotion of vaccine usage and cancer screening after future retraction of the recommendation suspension. This may apply to other countries with an unsatisfactory rate of HPV vaccination due to fears of adverse vaccine events.

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  • Susceptibility to male infertility: replication study in Japanese men looking for an association with four GWAS-derived loci identified in European men 査読

    Makoto Chihara, Kosuke Yoshihara, Tatsuya Ishiguro, Yuki Yokota, Sosuke Adachi, Hiroyuki Okada, Katsunori Kashima, Takaaki Sato, Atsushi Tanaka, Kenichi Tanaka, Takayuki Enomoto

    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS   32 ( 6 )   903 - 908   2015年6月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    A previous genome-wide association study in European men identified four single nucleotide polymorphism (SNP) loci associated with male infertility. Our aim was to replicate, if possible, the association of these SNPs with Japanese male infertility.
    We genotyped four SNPs (rs5911500, rs10246939, rs2059807, and rs11204546) in 517 Japanese patients with male infertility and 369 fertile controls using SNP-specific real-time polymerase chain reaction TaqMan assays. Subsequently, we divided patients with male infertility into azoospermia (n = 417) and oligospermia subgroups (n = 70).
    The four SNPs previously identified in European men showed no significant association with collective male infertility in our Japanese cohort. However, allele frequency analysis did indicate a significantly higher frequency of the rs11204546 C allele of the OR2W3 gene in the oligospermia subset of infertility patients compared with controls (p = 0.0037; odds ratio = 1.74; 95 % confidence interval, 1.21-2.53).
    Although this study was somewhat limited by overall sample size, the OR2W3 gene polymorphism rs11204546 was significantly associated with oligospermia in Japanese men, suggesting that OR2W3 might be involved in genetic susceptibility to Japanese male infertility as well as in European males.

    DOI: 10.1007/s10815-015-0468-4

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  • 骨盤リンパ節郭清後、外腸骨血管に腸管が絞扼されたイレウスの2例

    西野 幸治, 安達 聡介, 西川 伸道, 関根 正幸, 榎本 隆之, 山田 沙季, 佐藤 優, 石川 卓, 若井 俊文

    日本婦人科腫瘍学会雑誌   33 ( 3 )   620 - 620   2015年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 遺伝性乳がん卵巣がん症候群(HBOC)と遺伝カウンセリング HBOCにおける卵巣がんの特異性と対応

    関根 正幸, 榎本 隆之

    日本遺伝カウンセリング学会誌   36 ( 1 )   33 - 37   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本遺伝カウンセリング学会  

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  • Japan's failure to vaccinate girls against human papillomavirus 査読

    Yutaka Ueda, Takayuki Enomoto, Masayuki Sekine, Tomomi Egawa-Takata, Akiko Morimoto, Tadashi Kimura

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY   212 ( 3 )   405 - 406   2015年3月

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    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

    OBJECTIVE: Human papillomavirus (HPV) vaccination has proven to be effective for prevention of HPV infection and HPV-associated precancerous cervical lesions.(1) However, HPV vaccination rates have remained flat, and whether or not to vaccinate has become a social issue. In the United States in 2013, HPV vaccine coverage for girls ages 13-17 years was only 57%.(2) A notable inhibitory factor to getting vaccinated has been reports of possible adverse effects. Safety concerns among US parents have increased (4.5% in 2008 to 16.4% in 2010), as have intentions not to vaccinate their daughters against HPV (39.8% in 2008 to 43.9% in 2010; odds ratio for trend, 1.08; 95% confidence interval, 1.04-1.13).(3)
    STUDY DESIGN: In Japan, financial support of the government was initiated from 2011, and recommendation was initiated in April 2013. However, Japan has failed to capitalize on the HPV vaccine's potential for cervical cancer prevention. Japanese media reports in May and June 2013 concerning the vaccine's potential for adverse effects including complex regional pain syndrome and suspension of the government's recommendation for the vaccination on June 14, 2013, have led to public distrust and a dramatic decrease in HPV vaccination rates.(4) To demonstrate the depth of the problem, we analyzed the HPV vaccine coverage for 7th-grade girls in Sakai, Japan. We looked at those who had initiated their 3-dosage series either before or after the negative media reports ran. Girls from 7-11th grade were vaccination targets, with vaccinations at the 7th-grade level being the most desirable.
    RESULTS: The first trimester of the Japanese school year runs from April 1 through late July; the summer break is about 6 weeks. The adverse Japanese media reports and the Ministry of Health, Labor, and Welfare suspension announcement occurred about 40 days prior to summer vacation, during which the girls in Sakai were expected to go to a clinic for HPV vaccination. During the summer vacation period of 2012, nearly half of the 7th-grade girls got an inoculation. However, in 2013, the number of girls vaccinated in May began to decrease following the news reports, and by late June it was almost 0 (Figure, A). The vaccination rates of the 7-10th graders who had an opportunity for vaccination prior to the media reports were between 57.8-74.8% (2012). However, following the adverse reports, the rate plunged from 65.4% (2012) to 3.9% (2013) (incidence rate ratio, 0.060; 95% confidence interval, 0.051-0.071) (Figure, B). The girls received HPV vaccination mostly in the 7th grade. The rate of the number of those vaccinated in 7th grade was 70.4% (7th grade: 2632; and 8-10th grade: 1105) in 2012. In 2013, not only the number of those vaccinated in 7th grade but also those in 8-10th grades decreased significantly (7th grade: 158; and 8-10th grade: 90).
    CONCLUSION: Improved education around the critical importance of HPV vaccine and screening for cervical cancer prevention is needed worldwide.

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  • Somatic Copy Number Alterations Associated with Japanese or Endometriosis in Ovarian Clear Cell Adenocarcinoma 査読

    Aikou Okamoto, Jalid Sehouli, Nozomu Yanaihara, Yukihiro Hirata, Ioana Braicu, Byoung-Gie Kim, Satoshi Takakura, Misato Saito, Satoshi Yanagida, Masataka Takenaka, Noriko Yamaguchi, Asuka Morikawa, Hiroshi Tanabe, Kyosuke Yamada, Kosuke Yoshihara, Takayuki Enomoto, Hiroaki Itamochi, Junzo Kigawa, Noriomi Matsumura, Ikuo Konishi, Satoshi Aida, Yuko Aoki, Nobuya Ishii, Kazunori Ochiai, Tetsu Akiyama, Mitsuyoshi Urashima

    PLOS ONE   10 ( 2 )   e0116977   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    When compared with other epithelial ovarian cancers, the clinical characteristics of ovarian clear cell adenocarcinoma (CCC) include 1) a higher incidence among Japanese, 2) an association with endometriosis, 3) poor prognosis in advanced stages, and 4) a higher incidence of thrombosis as a complication. We used high resolution comparative genomic hybridization (CGH) to identify somatic copy number alterations (SCNAs) associated with each of these clinical characteristics of CCC. The Human Genome CGH 244A Oligo Microarray was used to examine 144 samples obtained from 120 Japanese, 15 Korean, and nine German patients with CCC. The entire 8q chromosome (minimum corrected p-value: q = 0.0001) and chromosome 20q13.2 including the ZNF217 locus (q = 0.0078) were amplified significantly more in Japanese than in Korean or German samples. This copy number amplification of the ZNF217 gene was confirmed by quantitative real-time polymerase chain reaction (Q-PCR). ZNF217 RNA levels were also higher in Japanese tumor samples than in non-Japanese samples (P = 0.027). Moreover, endometriosis was associated with amplification of EGFR gene (q = 0.047), which was again confirmed by Q-PCR and correlated with EGFR RNA expression. However, no SCNAs were significantly associated with prognosis or thrombosis. These results indicated that there may be an association between CCC and ZNF217 amplification among Japanese patients as well as between endometriosis and EGFR gene amplifications.

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  • Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion 査読

    Koji Matsuo, Kiyoshi Yoshino, Kosei Hasegawa, Ryusuke Murakami, Yuji Ikeda, Sosuke Adachi, Kosuke Hiramatsu, Takuhei Yokoyama, Masato Nishimura, Todd B. Sheridan, Takayuki Enomoto, Keiichi Fujiwara, Noriomi Matsumura, Ikuo Konishi, Christina Fotopoulou, Lynda D. Roman, Anil K. Sood

    GYNECOLOGIC ONCOLOGY   136 ( 2 )   198 - 204   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Background. The clinical impact of lympho-vascular space invasion (LVSI) in early-stage ovarian clear cell carcinoma (OCCC) is not well understood. Given the distinct tumor biology and survival patterns of OCCC, the significance of LVSI on survival outcome and treatment response was examined in OCCC.
    Methods. A multicenter study was conducted to examine stage IA-IC3 OCCC cases that underwent primary surgical staging including lymphadenectomy. LVSI status was determined from archived histopathology slides, correlated with clinico-pathological results, chemotherapy patterns, and survival outcomes.
    Results. LVSI was observed in 47 (20.3%) among 232 cases. In univariate analysis, LVSI was associated with older age (p = 0.042), large tumor size (p = 0.048), and stage IC (p = 0.035). In survival analysis, LVSI was associated with decreased disease-free survival (DFS, 5-year rate, 70.6% versus 92.1%, p = 0.0004) and overall survival (OS, 78.8% versus 93.3%, p = 0.008) on univariate analysis. After controlling for age, tumor size, stage, and chemotherapy use, LVSI remained an,independent prognostic factor for decreased survival outcomes (DFS, hazard ratio [HR] 4.35, 95% confidence interval [CI] 1.73-10.9, p = 0.002; and OS, HR 4.73, 95%CI 1.60-14.0, p = 0.015). Among 210 cases who received postoperative chemotherapy, while regimen type did not impact survival outcome regardless of LVSI status (DFS, p = 0.63), the number of administered cycles showed a survival benefit towards cycles for patients with LVSI-positive tumors (DFS, p = 0.009; and OS, p = 0.016).
    Conclusion. LVSI is an important marker to predict survival outcome of stage I OCCC. Regardless of chemotherapy type, patients with stage I OCCC showing LVSI may benefit from receiving postoperative chemotherapy. (C) 2014 Elsevier Inc. All rights reserved.

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  • Evaluation of a Free-Coupon Program for Cervical Cancer Screening Among the Young: A Nationally Funded Program Conducted by a Local Government in Japan 査読

    Yutaka Ueda, Tomotaka Sobue, Akiko Morimoto, Tomomi Egawa-Takata, Chie Hashizume, Hisayo Kishida, Satomi Okamoto, Kiyoshi Yoshino, Masami Fujita, Takayuki Enomoto, Yoshimi Tomine, Jun Fukuyoshi, Tadashi Kimura

    JOURNAL OF EPIDEMIOLOGY   25 ( 1 )   50 - 56   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC  

    Background: Finding ways to improve the cervical cancer screening rates among young women has been seen as a critical national health problem in many countries, including Japan. The aim of the present study was to evaluate the effects of a free-coupon program for cervical cancer screening conducted by a local government under financial support from the Japanese national government.
    Methods: The personal cervical cancer screening information was analyzed for all female residents of Toyonaka City, including any past screening history and clinical results since the year 2009, when a free-coupon program for screening was started. These results were compared to results from 2008, prior to implementation of the free-coupon screening program.
    Results: The screening rates of women eligible for the free-coupon peaked dramatically compared to women of similar age who paid for their screening; however, the rates for the ineligible-age population also increased significantly in parallel to those in the free-coupon program, possibly by indirect peer and publicity effects. In women aged 20 to 25 years, the consecutive screening rate after a free-coupon screening was significantly lower than for those women who received a regular residential screening. After a free-coupon screening, the rate for participating in consecutive screenings depended significantly on the institution where the participant received her first screening test.
    Conclusions: These results suggest that, for a generation of young women 20-25 years of age, a free-coupon program for cervical cancer screening was effective in increasing the first-time participation rate for screening; however, the increase in first-time participation did not lead to the expected increase in consecutive screenings.

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  • Complex chromosomal rearrangements in couples affected by recurrent spontaneous abortion 査読

    Taro Nonaka, Izumi Ooki, Takayuki Enomoto, Koichi Takakuwa

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   128 ( 1 )   36 - 39   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: To determine the proportion of couples affected by recurrent spontaneous abortion in which one partner carries balanced translocations among three chromosomes. Methods: In a retrospective study, G-banded chromosome complements were analyzed for couples affected by recurrent spontaneous abortion who were referred to Niigata University Hospital, Japan, between January 1, 1990, and December 31, 2011. The frequency of couples in whom one of the partners carried balanced translocations among three chromosomes was determined, and the clinical outcomes for affected couples who subsequently achieved term pregnancies were reviewed. Results: Of 1415 couples with recurrent spontaneous abortion during the study period, there were two (0.1%) in which one of the partners (the woman in both cases) carried balanced translocations among three chromosomes. Both couples achieved a subsequent pregnancy that continued successfully and resulted in a phenotypically normal neonate. Conclusion: The frequency of balanced translocations among three chromosomes was estimated to be approximately 0.1% in a population affected by recurrent spontaneous abortion. With appropriate treatment based on careful examinations, affected couples can go on to achieve a successful pregnancy outcome. (C) 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ijgo.2014.07.018

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  • Identification of novel exonic mobile element insertions in epithelial ovarian cancers. 査読 国際誌

    Takahide Hayano, Shiro Yamada, Kazuyoshi Hosomichi, Hirofumi Nakaoka, Kosuke Yoshihara, Sosuke Adachi, Katsunori Kashima, Kenichi Tanaka, Takayuki Enomoto, Ituro Inoue

    Human genome variation   2   15030 - 15030   2015年

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    記述言語:英語  

    Mobile elements comprise about half of the human genome. Three active mobile element families (L1, Alu, and SVA) possibly cause diseases such as cancer. We conducted mobile element insertion (MEI) profiling of 44 epithelial ovarian cancers using exome-sequencing data. We identified a total of 106 MEIs using the Mobster program, 8 of which were novel exonic MEIs.

    DOI: 10.1038/hgv.2015.30

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  • Prenatal molecular diagnosis of X-linked hydrocephalus via a silent C924T mutation in the L1CAM gene 査読

    Takehiro Serikawa, Kenichi Nishiyama, Jun Tohyama, Ryushi Tazawa, Kiyoe Goto, Yoko Kuriyama, Kazufumi Haino, Yonehiro Kanemura, Mami Yamasaki, Koh Nakata, Koichi Takakuwa, Takayuki Enomoto

    CONGENITAL ANOMALIES   54 ( 4 )   243 - 245   2014年11月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    The Majewski syndrome or short rib-polydactyly syndrome (SRPS) type II is a lethal skeletal dysplasia characterized by severe IUGR (intrauterine growth restriction) and dysmorphic face, polydactyly, relatively proportionate head size at birth with later progression to microcephaly. A case of second trimester ultrasound diagnosis of SRPS type II is reported with review of the medical record of previous observed cases. Postmortem examination and radiogram confirmed the clinical diagnosis. Histological examination of the femoral epypheseal chondral plate showed an expanded and irregular hypertrophic zone. Moreover, characteristic cortico-medullary cysts of both kidneys and portal fibrosis were also demonstrated; findings consistent with the broad phenotypic spectrum of this rare skeletal disease.

    DOI: 10.1111/cga.12066

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  • Outcomes and Prognostic Factors for Adenocarcinoma/Adenosquamous Carcinomas Treated with Radical Hysterectomy and Adjuvant Therapy 査読

    Masayuki Yamaguchi, Yoko Yamagishi, Nobumichi Nishikawa, Masayuki Sekine, Takehiro Serikawa, Katsunori Kashima, Takayuki Enomoto

    Open Journal of Obstetrics and Gynecology   4 ( 14 )   909 - 915   2014年10月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 常染色体劣性多発性嚢胞腎が疑われた出生前診断症例に関する検討 査読

    生野 寿史, 山口 雅幸, 芹川 武大, 和田 雅樹, 榎本 隆之, 高桑 好一

    日本遺伝カウンセリング学会誌   35 ( 3 )   117 - 120   2014年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 医局の全面的支援をうけた出張による腹腔鏡手術の教育 関連病院全体での安全な手術の普及を目指して

    磯部 真倫, 安達 聡介, 榎本 隆之

    日本内視鏡外科学会雑誌   19 ( 7 )   643 - 643   2014年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内視鏡外科学会  

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  • Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner 査読

    Akiko Morimoto, Satoshi Serada, Takayuki Enomoto, Ayako Kim, Shinya Matsuzaki, Tsuyoshi Takahashi, Yutaka Ueda, Kiyoshi Yoshino, Masami Fujita, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka

    ONCOTARGET   5 ( 17 )   7776 - 7787   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IMPACT JOURNALS LLC  

    Platinum resistance has long been a major issue in the treatment of various cancers. We previously reported that enhanced annexin A4 (ANXA4) expression, a Ca2+-regulated phospholipid-binding protein, induces chemoresistance to platinum-based drugs. In this study, we investigated the role of annexin repeats, a conserved structure of all the annexin family, responsible for platinum-resistance as well as the effect of knockdown of ANXA4. ANXA4 knockdown increased sensitivity to platinum-based drugs both in vitro and in vivo. To identify the domain responsible for chemoresistance, ANXA4 deletion mutants were constructed by deleting annexin repeats one by one from the C terminus. Platinum resistance was induced both in vitro and in vivo in cells expressing either full-length ANXA4 or the deletion mutants, containing at least one intact annexin repeat. However, cells expressing the mutant without any calcium-binding sites in the annexin repeated sequence, which is essential for ANXA4 translocation from the cytosol to plasma membrane, failed to acquire platinum resistance. After cisplatin treatment, the intracellular chloride ion concentration, whose channel is partly regulated by ANXA4, significantly increased in the platinum-resistant cells. These findings indicate that the calcium-binding site in the annexin repeat induces chemoresistance to the platinum-based drug by elevating the intracellular chloride concentration.

    DOI: 10.18632/oncotarget.2306

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  • Successful management of severe intrahepatic cholestasis of pregnancy: report of a first Japanese case 査読

    Kenya Kamimura, Hiroyuki Abe, Naomi Kamimura, Masayuki Yamaguchi, Maiko Mamizu, Kanna Ogi, Yoshifumi Takahashi, Ken-ichi Mizuno, Hiroteru Kamimura, Yuji Kobayashi, Manabu Takeuchi, Kunihiko Yoshida, Kyoko Yamada, Takayuki Enomoto, Koichi Takakuwa, Minoru Nomoto, Miki Obata, Yoshinori Katsuragi, Yukio Mishima, Ryo Kominami, Tomoteru Kamimura, Yutaka Aoyagi

    BMC GASTROENTEROLOGY   14   160   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: Intrahepatic cholestasis of pregnancy (ICP) is a cholestasis condition caused by elevated levels of serum bile acids that mainly occurs in the third trimester of pregnancy. Maternal symptoms include pruritus; elevation of transaminases, biliary enzymes, and bilirubin levels; and abnormal liver function tests. Fetal symptoms include spontaneous preterm labor, fetal distress, and intrauterine death. It is more prevalent in the Caucasians and is rarely found in Asian countries, including Japan. The etiology of ICP has been reported as involving various factors such as, environmental factors, hormone balance, and genetic components. The genetic factors include single-nucleotide polymorphisms (SNPs) in the genes of canalicular transporters, including ABCB4 and ABCB11. It has also been reported that the combination of these SNPs induces severe cholestasis and liver dysfunction.
    Case presentation: Here, we report for the first time a 24-year Japanese case of severe ICP diagnosed by typical symptoms, serum biochemical analysis, and treated with the administration of ursodeoxycholic acid which improved cholestasis and liver injury and prevented fetal death. The sequence analysis showed SNPs reported their association with ICP in the ABCB11 (rs2287622, V444A) and ABCB4 (rs1202283, N168N) loci.
    Conclusion: The risk of ICP has been reported to be population-specific, and it is rare in the Japanese population. Our case was successfully treated with ursodeoxycholic acid and the genetic sequence analysis has supported the diagnosis. Because genetic variation in ABCB4 and ABCB11 has also been reported in the Japanese population, we need to be aware of potential ICP cases in pregnant Japanese women although further studies are necessary.

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  • 妊娠26週未満破水症例の後方視的検討 招待 査読

    鈴木 美保, 山口 雅幸, 島 英里, 冨永 麻理恵, 松本 賢典, 田村 亮, 佐藤 ひとみ, 能仲 太郎, 榎本 隆之, 生野 寿史, 高桑 好一

    新潟産科婦人科学会会誌   109 ( 2 )   79 - 84   2014年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:新潟産科婦人科学会 ; 2011-  

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    その他リンク: http://search.jamas.or.jp/link/ui/2015087120

  • 重篤な疾患を合併する妊産婦の管理 泌尿器系 腎不全、透析中の妊娠 招待 査読

    高桑 好一, 能仲 太郎, 佐藤 ひとみ, 生野 寿史, 山口 雅幸, 榎本 隆之

    周産期医学   44 ( 9 )   1177 - 1179   2014年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 保険適応となった腹腔鏡下子宮体がん根治術 当院での施行状況の報告

    磯部 真倫, 安達 聡介, 関塚 智之, 君島 世理, 風間 絵里菜, 山岸 葉子, 茅原 誠, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 加嶋 克則, 榎本 隆之

    新潟産科婦人科学会会誌   109 ( 2 )   116 - 116   2014年9月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 腹腔鏡下子宮体がん根治術 保険適応後の施行状況

    安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 加嶋 克則, 榎本 隆之

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   62回   58 - 58   2014年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • 新潟県における腹腔鏡手術教育の現況 関連病院全体で安全な手術の普及を目指して

    磯部 真倫, 安達 聡介, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 加嶋 克則, 榎本 隆之

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   62回   49 - 49   2014年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • 淋菌性腹膜炎で麻痺性イレウスを呈した1例

    松本 賢典, 磯部 真倫, 加嶋 克則, 榎本 隆之

    新潟産科婦人科学会会誌   109 ( 2 )   72 - 74   2014年9月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    17歳女。既往歴として1年前に性感染症と診断され抗菌薬治療を受けていた。当科受診の2週間前から腹痛があり、徐々に増強し発熱も伴ってきたため救急車を要請し、当院に搬送された。腹部は全体的に膨満して硬く、反跳痛と筋性防御を認め、内診では子宮頸部可動痛を認めた。腹部X線で大腸ガスと小腸ガスを認め、ニボー像も認めた。腹部骨盤部造影CTで小腸や大腸の拡張と液体貯留、壁肥厚濃染を認め、虫垂炎の所見は認めなかった。既往歴と各種所見から骨盤内炎症疾患(PID)に起因するイレウスと考え、抗菌薬治療を行った。使用する抗菌薬については、PIDの原因菌としてクラミジア・嫌気性菌が多いことや、性感染症の既往があり淋菌感染も否定できないことなどを考慮し、アジスロマイシン、クリンダマイシン、セフトリアキソンを選択した。結果、投与開始後に症状・検査所見とも速やかに改善し、第7病日に退院となった。子宮頸部擦過検体の淋菌DNA検査で陽性を示し、クラミジアDNAは陰性であった。

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  • 後腹膜発育の子宮筋腫を有する子宮に対して全腹腔鏡下子宮全摘(TLH)をおこなった1症例

    山脇 芳, 磯部 真倫, 西川 伸道, 芹川 武大, 榎本 隆之

    新潟産科婦人科学会会誌   109 ( 2 )   108 - 108   2014年9月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 腹腔鏡下手術を施行した傍卵巣腫瘍の臨床的検討

    加嶋 克則, 山岸 葉子, 茅原 誠, 安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 芹川 武大, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   223 - 223   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 小児腟原発ブドウ状肉腫の診断と治療に鏡視下手術が有用であった1例

    山岸 葉子, 須田 一暁, 茅原 誠, 安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 加嶋 克則, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   205 - 205   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 胎盤遺残に対し子宮動脈塞栓術後に子宮鏡下切除術を行い子宮温存が可能であった3例の検討

    茅原 誠, 関根 正幸, 山岸 葉子, 安達 聡介, 磯部 真倫, 生野 寿史, 西野 幸治, 山口 雅幸, 西川 伸道, 芹川 武大, 加嶋 克則, 高桑 好一, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   209 - 209   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 認知症を有する高齢者の巨大卵巣腫瘍に対して腹腔鏡下手術を施行した一例

    安達 聡介, 磯部 真倫, 関塚 智之, 芹川 武大, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   223 - 223   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 医局の全面的支援をうけた積極的出張による腹腔鏡手術の教育 関連病院全体での安全な腹腔鏡手術の普及を目指して

    磯部 真倫, 山岸 葉子, 茅原 誠, 安達 聡介, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 加嶋 克則, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   128 - 128   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • Two cases of recurrent abortion in which isodicentric chromosome 15 was observed in the husbands 査読

    Taro Nonaka, Izumi Ooki, Takayuki Enomoto, Koichi Takakuwa

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   40 ( 6 )   1795 - 1798   2014年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    We report two cases of women positive for anticardiolipin antibodies who experienced recurrent abortion whose husbands had isodicentric chromosome 15 aberrations who eventually had successful pregnancies. Two women were referred to our hospital due to their medical history of recurrent abortion. Both were diagnosed as being positive for anticardiolipin antibodies and their husbands with isodicentric chromosome 15. After both patients were treated with a Japanese herbal medicine (Sairei-to) and low-dose aspirin for the positive anticardiolipin antibodies, they delivered appropriate-for-date infants at term gestation. Although both husbands were revealed to have isodicentric chromosome 15, and coincidentally both wives were positive for anticardiolipin antibodies, their next pregnancies continued uneventfully as a result of the treatment.

    DOI: 10.1111/jog.12401

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  • Preoperative Ultrasound-Guided Needle Biopsy of 63 Uterine Tumors Having High Signal Intensity Upon T2-Weighted Magnetic Resonance Imaging 査読

    Ryo Tamura, Katsunori Kashima, Mina Asatani, Koji Nishino, Nobumichi Nishikawa, Masayuki Sekine, Takehiro Serikawa, Takayuki Enomoto

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 6 )   1042 - 1047   2014年6月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objective The differential diagnosis between uterine sarcoma and benign leiomyoma is difficult when made only by magnetic resonance imaging (MRI); it usually requires an additional preoperative diagnostic procedure. We report our results using ultrasound-guided needle biopsy for these types of uterine tumors.
    Methods Ultrasound-guided needle biopsy was performed on 63 patients with uterine smooth muscle tumors suspected of malignancy by MRI. We compared the results of presurgical biopsy against the postsurgical pathology of the tumor.
    Results Among 63 patients with a high signal intensity of the uterine tumor on T2-weighted MRI (1 case was undetermined), 12 cases (19.3%) were diagnosed by the needle biopsy as malignant, and 51 cases (80.6%) were benign. Among the 12 diagnosed as malignant tumors, 11 had surgery performed, and one was treated with chemotherapy. Among the 51 patients diagnosed with a benign tumor, 27 had surgery performed, and 24 were put on a wait-and-see clinical follow-up schedule. One of the 27 surgical patients with a benign tumor had a postsurgical diagnosis of a low-grade endometrial stromal sarcoma. In the 38 cases where surgery was performed, we found the sensitivity, specificity, and the positive and negative predictive values of the needle biopsy were 91.7%, 100%, 100%, and 96.2%, respectively.
    Conclusions Ultrasound-guided needle biopsy may be a reliable preoperative diagnostic procedure for uterine tumors with suspected malignancy.

    DOI: 10.1097/IGC.0000000000000189

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  • 当院における婦人科悪性腫瘍脳転移症例の臨床的検討

    山岸 葉子, 山脇 芳, 茅原 誠, 安達 聡介, 萬歳 千秋, 磯部 真倫, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 加嶋 克則, 榎本 隆之

    日本癌治療学会誌   49 ( 3 )   1527 - 1527   2014年6月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • 妊娠初期に発見された子宮頸癌に対して広汎子宮頸部摘出術を施行した2症例

    西川 伸道, 芹川 武大, 山脇 芳, 山岸 葉子, 横田 有紀, 茅原 誠, 安達 聡介, 磯部 真倫, 生野 寿史, 西野 幸治, 山口 雅幸, 関根 正幸, 加嶋 克則, 高桑 好一, 榎本 隆之

    日本癌治療学会誌   49 ( 3 )   1762 - 1762   2014年6月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • 進行卵巣癌における再発部位の検討

    安達 聡介, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 芹川 武大, 加嶋 克則, 榎本 隆之

    日本婦人科腫瘍学会雑誌   32 ( 3 )   502 - 502   2014年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • Effect of Lymphovascular Space Invasion on Survival of Stage I Epithelial Ovarian Cancer 査読

    Koji Matsuo, Kiyoshi Yoshino, Kosuke Hiramatsu, Chiaki Banzai, Kosei Hasegawa, Masanori Yasuda, Masato Nishimura, Todd B. Sheridan, Yuji Ikeda, Yasuhiko Shiki, Seiji Mabuchi, Takayuki Enomoto, Tadashi Kimura, Keiichi Fujiwara, Lynda D. Roman, Anil K. Sood

    OBSTETRICS AND GYNECOLOGY   123 ( 5 )   957 - 965   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    OBJECTIVE: To evaluate the effect of lymphovascular space invasion on survival of patients with early-stage epithelial ovarian cancer.
    METHODS: A multicenter retrospective study was conducted for patients with stage IA-C epithelial ovarian cancer who underwent primary comprehensive surgery including lymphadenectomy. Histopathology slides for ovarian tumors were examined by gynecologic pathologists for the presence or absence of lymphovascular space invasion. Survival analysis was performed examining tumoral factors.
    RESULTS: A total of 434 patients were included in the analysis. Lymphovascular space invasion was detected in 76 (17.5%) patients associated with histology (P=.042) and stage (P=.044). Lymphovascular space invasion was significantly associated with decreased survival outcomes (disease-free survival, 5-year rate 78.4% compared with 90.7%, P=.024 and overall survival, 84.9% compared with 93.2%, P=.031) in univariate analysis. In multivariate analysis, lymphovascular space invasion did not remain a significant variable for disease-free survival (hazard ratio [HR] 1.98, 95% confidence interval [CI] 0.97-3.97, P=059) or overall survival (HR 2.41, 95% CI 0.99-5.85, P=052). Lymphovascular space invasion was associated with increased risk of hematogenous and lymphatic metastasis (HR 4.79, 95% CI 1.75-13.2, P=002) but not peritoneal metastasis (P=.33) in multivariate analysis. Among lymphovascular space invasion-expressing tumors, patients who received fewer than six cycles of postoperative chemotherapy had significantly poorer disease-free survival than those who received six or more cycles (HR 4.59, 95% CI 1.20-17.5, P=.015).
    CONCLUSION: Lymphovascular space invasion is an important histologic feature to identify a subgroup of patients with increased risk of recurrence in stage I epithelial ovarian cancer.

    DOI: 10.1097/AOG.0000000000000240

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  • Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A 査読

    Shinya Matsuzaki, Takayuki Enomoto, Satoshi Serada, Kiyoshi Yoshino, Shushi Nagamori, Akiko Morimoto, Takuhei Yokoyama, Ayako Kim, Toshihiro Kimura, Yutaka Ueda, Masami Fujita, Minoru Fujimoto, Yoshikatsu Kanai, Tadashi Kimura, Tetsuji Naka

    INTERNATIONAL JOURNAL OF CANCER   134 ( 8 )   1796 - 1809   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Although platinum drugs are often used for the chemotherapy of human cancers, platinum resistance is a major issue and may preclude their use in some cases. We recently reported that enhanced expression of Annexin A4 (Anx A4) increases chemoresistance to carboplatin through increased extracellular efflux of the drug. However, the precise mechanisms underlying that chemoresistance and the relationship of Anx A4 to platinum resistance in vivo remain unclear. In this report, the in vitro mechanism of platinum resistance induced by Anx A4 was investigated in endometrial carcinoma cells (HEC1 cells) with low expression of Anx A4. Forced expression of Anx A4 in HEC1 cells resulted in chemoresistance to platinum drugs. In addition, HEC1 control cells were compared with Anx A4-overexpressing HEC1 cells in xenografted mice. Significantly greater chemoresistance to cisplatin was observed in vivo in Anx A4-overexpressing xenografted mice. Immunofluorescence analysis revealed that exposure to platinum drugs induced relocation of Anx A4 from the cytoplasm to the cellular membrane, where it became colocalized with ATP7A, a copper transporter also well known as a mechanism of platinum efflux. ATP7A expression suppressed by small interfering RNA had no effect on HEC1 control cells in terms of chemosensitivity to platinum drugs. However, suppression of ATP7A in Anx A4-overexpressing platinum-resistant cells improved chemosensitivity to platinum drugs (but not to 5-fluorouracil) to a level comparable to that of control cells. These results indicate that enhanced expression of Anx A4 confers platinum resistance by promoting efflux of platinum drugs via ATP7A.

    DOI: 10.1002/ijc.28526

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  • 産婦人科医必携 現代漢方の基礎知識 不育症・習慣流産 招待

    高桑 好一, 能仲 太郎, 高橋 真紀子, 山岸 葉子, 吉田 邦彦, 生野 寿史, 山口 雅幸, 榎本 隆之

    産婦人科の実際   63 ( 3 )   363 - 371   2014年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Endometrial Adenocarcinoma Arising in a Turner's Syndrome Patient with Spontaneous Menstruation A Case Report 査読

    Naoko Sasamoto, Yutaka Ueda, Kyoka Amemiya, Takayuki Enomoto, Eiichi Morii, Kazushige Adachi

    JOURNAL OF REPRODUCTIVE MEDICINE   59 ( 3-4 )   177 - 180   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SCI PRINTERS & PUBL INC  

    BACKGROUND: Women with Turner's syndrome exhibit anovulation, and the majority do not sponta-syndrome detected spontaneous menstruation in only neously menstruate. We present an unusual case of endometrial adenocarcinoma developing in a Turner's syndrome patient who was exhibiting spontaneous menstruation while not receiving regular hormone therapy.
    CASE: The patient's karyotype from blood lymphocytes was a mosaic of 45,XO/46,XX. Menarche and sexual development were normal. Her menstrual cycle had been regular for one year, but then became noticeably irregular. At age 26 she was referred to our hospital after bleeding for almost 1 year. An endometrial adenocarcinoma was detected during performance of diagnostic endometrial curettage. A total abdominal hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was conducted. The final histological diagnosis was endometrial adenocarcinoma, Grade 1, pT1a NO MO. Fluorescence in situ hybridization analysis of the right and left ovaries revealed a mosaic karyotype of 45,XO/46,XX/47,XXX.
    CONCLUSION: Previous reports regarding Turner's syndrome detected spontaneous menstruation in only 16% of patients; however, spontaneous menstruation was observed in 8 of 10 (80%) Turner's syndrome cases that developed endometrial carcinoma without receiving regular hormone therapy (p &lt; 0.0001). Hormone therapy may be indicated for an irregular menstrual cycle in Turner's syndrome patients.

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  • Molecular characterization of an intact p53 pathway subtype in high-grade serous ovarian cancer. 査読 国際誌

    Takahide Hayano, Yuki Yokota, Kazuyoshi Hosomichi, Hirofumi Nakaoka, Kosuke Yoshihara, Sosuke Adachi, Katsunori Kashima, Hitoshi Tsuda, Takuya Moriya, Kenichi Tanaka, Takayuki Enomoto, Ituro Inoue

    PloS one   9 ( 12 )   e114491   2014年

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    記述言語:英語  

    High-grade serous ovarian cancer (HGSOC) is the most aggressive histological type of epithelial ovarian cancer, which is characterized by a high frequency of somatic TP53 mutations. We performed exome analyses of tumors and matched normal tissues of 34 Japanese patients with HGSOC and observed a substantial number of patients without TP53 mutation (24%, 8/34). Combined with the results of copy number variation analyses, we subdivided the 34 patients with HGSOC into subtypes designated ST1 and ST2. ST1 showed intact p53 pathway and was characterized by fewer somatic mutations and copy number alterations. In contrast, the p53 pathway was impaired in ST2, which is characterized by abundant somatic mutations and copy number alterations. Gene expression profiles combined with analyses using the Gene Ontology resource indicate the involvement of specific biological processes (mitosis and DNA helicase) that are relevant to genomic stability and cancer etiology. In particular we demonstrate the presence of a novel subtype of patients with HGSOC that is characterized by an intact p53 pathway, with limited genomic alterations and specific gene expression profiles.

    DOI: 10.1371/journal.pone.0114491

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  • 遺伝性卵巣癌の発症に関与する新規原因遺伝子の同定

    関根 正幸, 田中 憲一, 榎本 隆之

    新潟県医師会報   ( 765 )   10 - 12   2013年12月

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    記述言語:日本語   出版者・発行元:新潟県医師会  

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  • Placenta previa and percreta with massive genital bleeding in the first trimester of pregnancy: A case report 査読

    Masayuki Yamaguchi, Kunihiko Yoshida, Toru Takano, Takayuki Enomoto, Koichi Takakuwa

    Open Journal of Obstetrics and Gynecology   3 ( 9 )   690 - 693   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 初期子宮体癌に対する腹腔鏡下根治手術 複数術者によるfeasibilityと予後の検討 査読

    安達聡介, 八幡哲郎, 工藤梨沙, 山岸葉子, 山脇芳, 須田一暁, 田村亮, 茅原誠, 南川高廣, 萬歳千秋, 西野幸治, 西川伸道, 加嶋克則, 榎本隆之

    日本産科婦人科内視鏡学会雑誌   29 ( 1 )   313 - 317   2013年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOCIETY OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY AND MINIMALLY INVASIVE THERAPY  

    Laparoscopy has been widely proposed as an alternative to a laparotomy for the treatment of early stage endometrial cancer. The purpose of this study was to assess the efficacy, safety, and prognosis of laparoscopic surgery. We retrospectively analyzed the results of laparoscopic surgery for patients with early stage endometrial cancer at the Department of Obstetrics and Gynecology, Niigata University Medical & Dental Hospital between 2003 and 2011. A total of 44 patients underwent laparoscopic surgery by three different surgeons. Blood loss and number of lymph nodes removed were not statistically significant between surgeons. Although a significant difference in surgery time (P = 0.0017) was initially observed between surgeons, this difference became insignificant as the surgeons gained experience. With increasing surgeons' experience, laparoscopic surgery is useful for the treatment of early stage endometrial cancer.

    DOI: 10.5180/jsgoe.29.313

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    その他リンク: http://search.jamas.or.jp/link/ui/2014188363

  • Authors' response. 査読 国際誌

    Kosuke Hiramatsu, Yutaka Ueda, Kiyoshi Yoshino, Masami Fujita, Eiichi Morii, Takayuki Enomoto, Tadashi Kimura

    European journal of obstetrics, gynecology, and reproductive biology   170 ( 1 )   297 - 297   2013年9月

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  • A phase II study of combination chemotherapy using docetaxel and irinotecan for TC-refractory or TC-resistant ovarian carcinomas (GOGO-OV2 study) and for primary clear or mucinous ovarian carcinomas (GOGO-OV3 Study) 査読

    Yutaka Ueda, Takashi Miyatake, Masaaki Nagamatsu, Masato Yamasaki, Yukihiro Nishio, Kiyoshi Yoshino, Masami Fujita, Tateki Tsutsui, Takayuki Enomoto, Tadashi Kimura

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   170 ( 1 )   259 - 263   2013年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Objective: To analyze the efficacy and safety of combination chemotherapy of docetaxel and irinotecan for paclitaxel and carboplatin (TC) -refractory or -resistant ovarian carcinomas and for first treatment of primary clear cell and mucinous ovarian carcinomas.
    Study design: Between 2002 and 2009, we conducted a prospective Phase II study of the efficacy and safety of combination chemotherapy using docetaxel and irinotecan in 62 patients with TC-refractory or -resistant ovarian carcinoma cases (GOGO-OV2) and 15 patients with primary clear cell and mucinous ovarian carcinoma cases (GOGO-OV3). The dose of docetaxel and irinotecan was determined during our previous Phase I study.
    Results: A docetaxel plus irinotecan regimen provided a 53% response rate, 6 months progression-free survival (PFS), and 12 months overall survival (OS) for primary clear cell and mucinous ovarian carcinomas (similar to TC therapy). The differences of anti-tumor and survival effects between refractory and resistant cases were not statistically significant. The regimen also provided a 15% response rate, 5 months PFS, and 15 months OS for TC-refractory or TC-resistant cases, when used as a second-line chemotherapy. These data are similar to previous reports, however, our study provides the first data exclusively for the cases refractory or resistant to a gold standard TC therapy as a second-line chemotherapy. The regimen was demonstrated to be well tolerable.
    Conclusion: Combination chemotherapy of docetaxel and irinotecan may be a useful option to treat TC-refractory/resistant cases and primary clear cell and mucinous adenocarcinoma cases of ovarian carcinoma. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ejogrb.2013.06.035

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  • Endometrial cancer: preoperative staging using three-dimensional T2-weighted turbo spin-echo and diffusion-weighted MR imaging at 3.0 T: a prospective comparative study 査読

    Masatoshi Hori, Tonsok Kim, Hiromitsu Onishi, Izumi Imaoka, Yuki Kagawa, Takamichi Murakami, Atsushi Nakamoto, Takashi Ueguchi, Mitsuaki Tatsumi, Takayuki Enomoto, Tadashi Kimura, Noriyuki Tomiyama

    EUROPEAN RADIOLOGY   23 ( 8 )   2296 - 2305   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    To prospectively assess the efficacy of 3-T magnetic resonance (MR) imaging using the three-dimensional turbo spin-echo T2-weighted and diffusion-weighted technique (3D-TSE/DW) compared with that of conventional imaging using the two-dimensional turbo spin-echo T2-weighted and dynamic contrast-enhanced technique (2D-TSE/DCE) for the preoperative staging of endometrial cancer, with pathological analysis as the reference standard.
    Seventy-one women with endometrial cancer underwent MR imaging using 3D-TSE/DW (b = 1,000 s/mm(2)) and 2D-TSE/DCE. Two radiologists independently assessed the two imaging sets. Accuracy, sensitivity, and specificity for staging were analysed with the McNemar test; the areas under the receiver operating characteristic curve (Az) were compared with a univariate z-score test.
    The results for assessing deep myometrial invasion, accuracy, sensitivity, specificity and Az, respectively, were as follows: 3D-TSE/DW-observer 1, 87 %, 95 %, 85 % and 0.96; observer 2, 92 %, 84 %, 94 % and 0.95; 2D-TSE/DCE-observer 1, 80 %, 79 %, 81 % and 0.89; observer 2, 86 %, 84 %, 87 % and 0.86. Most of the values were higher with 3D-TSE/DW without significant differences (P &gt; 0.12). For assessing cervical stromal invasion, there were no significant differences in those values for both observers (P &gt; 0.6).
    Accuracy of 3D-TSE/DW was at least equivalent to that of the conventional technique for the preoperative assessment of endometrial cancer.

    DOI: 10.1007/s00330-013-2815-0

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  • Taxane-sensitivity of ovarian carcinomas previously treated with paclitaxel and carboplatin 査読

    Yutaka Ueda, Takayuki Enomoto, Shinya Matsuzaki, Eiji Kobayashi, Toshihiro Kimura, Kiyoshi Yoshino, Masami Fujita, Tateki Tsutsui, Tadashi Kimura

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   71 ( 6 )   1411 - 1416   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The aim of the present study was to investigate, in ovarian carcinoma cases, the predictive association between the treatment-free interval (TFI) after an initial paclitaxel plus carboplatin (TC) therapy and the subsequent effectiveness of a second-line taxane-containing chemotherapy.
    Patients with a TFI &lt; 6 months from the first-line TC therapy were treated with a combination chemotherapy using docetaxel and irinotecan; patients with a TFI a parts per thousand yen 6 months were retreated with the same regimen as the initial TC therapy. The clinical data of these patients were retrospectively analyzed for this study.
    The response rate of those with a TFI equal to 6-12 months was greater than that of those with a TFI &lt; 6 months (p = 0.014) and less than that of those with a TFI &gt; 12 months (p = 0.012). The progression-free survival of the cases with TFI equal to 6-12 months was longer than that of those with TFI &lt; 6 months (p = 0.012) and shorter than that of those with TFI &gt; 12 months (p = 0.0011). Overall survival of cases with a TFI equal to 6-12 months was longer than that of those with TFI &lt; 6 months (p = 0.012) and shorter than that of those with TFI &gt; 12 months (p = 0.0005).
    The effectiveness of using a second-line taxane-containing chemotherapy was shown to be predictable by the TFI after the first-line taxane-containing chemotherapy, implying that the theory of 'taxane-sensitivity' may be applied for second-line chemotherapy in the same way as that of 'platinum-sensitivity'.

    DOI: 10.1007/s00280-013-2138-5

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  • Conization using the Shimodaira-Taniguchi procedure for adenocarcinoma in situ of the uterine cervix. 査読 国際誌

    Kosuke Hiramatsu, Yutaka Ueda, Kiyoshi Yoshino, Masami Fujita, Eiichi Morii, Takayuki Enomoto, Tadashi Kimura

    European journal of obstetrics, gynecology, and reproductive biology   168 ( 2 )   218 - 21   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The Shimodaira-Taniguchi conization procedure addresses the disadvantages of the loop electrosurgical excision procedure (LEEP) by using a high frequency current and a triangular probe with a linear excision electrode to extract the tissue as a single informative specimen, without incurring accompanying thermal trauma. The aim of the present study was to analyze the surgical efficacy of the Shimodaira-Taniguchi conization procedure for adenocarcinoma in situ (AIS) of the uterine cervix. STUDY DESIGN: At the Osaka University Hospital, conization using the Shimodaira-Taniguchi procedure has long been routinely performed for AIS. Medical records of patients during the period from 2005 to 2011, whose post-conization diagnosis was AIS, were retrospectively analyzed. A literature review was conducted of the PubMed database to clarify the surgical outcome efficacy of the Shimodaira-Taniguchi procedure compared to other procedures. RESULTS: During the study period, a post-conization diagnosis of AIS was made in 10 patients. A positive resection margin was detected in 4 of the 10 cases (40%), and residual disease was observed in 3 cases (30%). A review of the relevant literature indicates that the rate of positive margin and residual disease by the Shimodaira-Taniguchi procedure, including our cases, was not significantly different from the cold knife, LEEP or laser procedures (p=0.32, 0.99, and 0.40, respectively, for positive margin, and p=0.76, 0.94, and 0.063, respectively, for residual disease). CONCLUSION: AIS was demonstrated to be efficaciously treated, with a low risk of residual disease, by the Shimodaira-Taniguchi conization procedure. Further study is still needed to establish a standard of conservative treatment for AIS.

    DOI: 10.1016/j.ejogrb.2013.01.011

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  • Annexin A4の機能領域解析を用いた癌細胞プラチナ耐性機構の解明

    森本 晶子, 榎本 隆之, 平松 宏祐, 松崎 慎哉, 横山 拓平, 小林 栄仁, 木村 敏啓, 上田 豊, 吉野 潔, 藤田 征巳, 仲 哲治, 木村 正

    日本婦人科腫瘍学会雑誌   31 ( 3 )   446 - 446   2013年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 腟カフ形成併用腹腔鏡下準広汎子宮全摘術