Updated on 2024/05/18

写真a

 
HORII Yosuke
 
Organization
University Medical and Dental Hospital Division of Radiology Associate Professor
Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Molecular Genetics Associate Professor
Title
Associate Professor
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The Best Research Achievement in Research Career

    • 【Papers】 Relationship between Heart Rate and Optimal Reconstruction Phase in Dual-source CT Coronary Angiography  2011.6

    • 【Papers】 Relationship between Heart Rate and Optimal Reconstruction Phase in Dual-source CT Coronary Angiography  2011.6

Degree

  • 博士(医学) ( 2011.3   新潟大学 )

Research Areas

  • Life Science / Radiological sciences

Research History

  • Niigata University   Division of Radiology, University Medical and Dental Hospital   Associate Professor

    2021.4

  • Niigata University   Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Molecular Genetics   Assistant Professor

    2015.7 - 2021.3

  • Niigata University   University Medical and Dental Hospital Diagnostic Radiology   Assistant Professor

    2014.4 - 2015.6

  • Niigata University   University Medical and Dental Hospital Diagnostic Radiology   Specially Appointed Assistant Professor

    2013.4 - 2014.3

 

Papers

  • Transcatheter coil embolization for large pulmonary arteriovenous fistulae through an artificial tricuspid ball valve.

    Sei Matsuo, Kazuyuki Ozaki, Yuji Matsuo, Toshiki Takano, Tohru Watanabe, Tatsuhiko Sato, Takuya Yagi, Tsugumi Takayama, Makoto Hoyano, Takao Yanagawa, Takuya Ozawa, Yosuke Horii, Tohru Takano, Takeshi Kashimura, Tohru Minamino

    Journal of cardiology cases   25 ( 1 )   1 - 5   2022.1

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    Language:English  

    Pulmonary arteriovenous fistulae (PAFs) occur congenitally or are acquired. A PAF can cause hypoxemia, sudden death from rupture, abscess formation, and embolism. Treatment for PAF is transcatheter embolization or surgery. Transcatheter embolization is the first choice of treatment; however, this treatment is impossible to perform if a patient has had tricuspid or pulmonary valve replacement. In this paper, we describe a case of PAFs complicated with tricuspid valve replacement with a ball valve (which had been performed 40 years earlier) that was treated with transcatheter embolization. <Learning objective: Although the ball valve was discontinued more than 40 years ago, it is still the only mechanical valve that allows catheter passage. We report a case of successful treatment of pulmonary arteriovenous fistula by passing a catheter through a ball valve.>.

    DOI: 10.1016/j.jccase.2021.05.006

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  • Low Tube Voltage Computed Tomography Venography for Patients With Deep Vein Thrombosis of the Lower Extremities ― A Comparison With Venous Ultrasonography ― Reviewed

    Tatsuhiko Sato, Norihiko Yoshimura, Yosuke Horii, Motohiko Yamazaki, Ken Sato, Kazuki Kumagai, Hiroyuki Ishikawa

    Circulation Journal   85 ( 4 )   369 - 376   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Circulation Society  

    BACKGROUND: Low tube voltage computed tomography venography (CTV) can be expected to increase imaging contrast and decrease radiation exposure by using iterative reconstruction (IR). This study evaluated the diagnostic ability of low tube voltage CTV with IR for deep vein thrombosis (DVT), compared to ultrasonography (US).Methods and Results:Two experienced radiologists retrospectively reevaluated the CTV data of 55 of 318 consecutive patients suspected of having DVT or pulmonary embolism between December 2015 and April 2017. The 55 patients had undergone both low tube voltage CTV and US (within 1 day before or after CTV). The lower extremity veins were divided into 10 segments. The DVT forms were categorized into 3 types: complete, concentric, and eccentric. We analyzed the 534 overall segments (16 segments excluded in US) measured using both CTV and US. The sensitivity-specificity was overall 73.3-90.0%, for femoropopliteal, it was 90.0-93.2%, and for the calf, it was 71.1-87.2%. The diagnostic accuracy between the 'eccentric only' and 'others' groups focusing on DVT forms was compared, and significant differences were revealed, especially in the muscular vein. CONCLUSIONS: The DVT diagnostic ability above the knee was comparable between low tube voltage CTV with IR and conventional CTV, and the radiation dose was reduced. It was suggested that eccentric DVT measured by CTV tend to be a false-positive, especially in the calf muscular vein.

    DOI: 10.1253/circj.cj-20-0416

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  • Bidirectional Shunt Trajectory in Ventricular Septal Defect With Eisenmenger’s Syndrome Reviewed

    Hiromi Kayamori, Takeshi Kashimura, Yosuke Horii, Tsutomu Kanazawa, Toshio Fujita, Naoki Kubota, Yasuhiro Ikami, Toshiki Takano, Takeshi Okubo, Makoto Hoyano, Takao Yanagawa, Takuya Ozawa, Kazuyuki Ozaki, Tohru Minamino

    Circulation Journal   82 ( 11 )   2925 - 2926   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Circulation Society  

    DOI: 10.1253/circj.cj-18-0332

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  • Coronary computed tomography angiography using 128-slice dual-source computed tomography in patients with severe calcification Reviewed

    Suguru Sato, Yosuke Horii, Norihiko Yoshimura, Takuya Yagi, Hidefumi Aoyama

    Japanese Journal of Radiology   35 ( 8 )   432 - 439   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    PURPOSE: To compare coronary computed tomography angiography (CTA) and coronary angiography (CAG) with regard to luminal graphic definition of calcified segments using 128-slice dual-source computed tomography (DSCT), specifically for patients with an Agatston score >400. MATERIALS AND METHODS: Of 1148 consecutive patients who underwent coronary CTA using a 128-slice DSCT, 132 subjects had severe calcification with an Agatston score >400. Thirty-nine of the 132 patients who had undergone CAG within 3 months before or after coronary CTA were included. We investigated the distribution of calcification, and we visually evaluated significant stenosis in the calcified and all segments. Results were compared with CAG. RESULTS: The target group in this study had a very high mean Agatston score of 1771 ± 1724. Results for sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 247 calcified vs all 325 segments were as follows: sensitivity 93.2 vs 92.2%, specificity 83.9 vs 87.5%, PPV 70.8 vs 69.6%, and NPV 96.7 vs 97.3%, respectively. CONCLUSION: 128-slice DSCT has potential for evaluation of calcified segments in the lumen, even in patients whose Agatston score exceeds 400.

    DOI: 10.1007/s11604-017-0650-y

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    Other Link: http://link.springer.com/content/pdf/10.1007/s11604-017-0650-y.pdf

  • Acute coronary syndrome: evaluation of detection capability using non-electrocardiogram-gated parenchymal phase CT imaging

    Motohiko Yamazaki, Takeshi Higuchi, Toshikazu Shimokoshi, Takao Kiguchi, Yosuke Horii, Norihiko Yoshimura, Hidefumi Aoyama

    Japanese Journal of Radiology   34 ( 5 )   331 - 338   2016.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    PURPOSE: To evaluate the capability to detect acute coronary syndrome (ACS) by using non-electrocardiogram-gated parenchymal phase CT imaging. MATERIALS AND METHODS: Of 962 consecutive patients who underwent emergent coronary angiography for suspected ACS, 32 with ACS who underwent CT ≤24 h before angiography and 15 without ACS who underwent CT ≤24 h before or after angiography were included. Parenchymal phase was acquired at 100-s scan delay. The presence of a myocardial perfusion defect (MPD) on the left ventricle (a decrease of >20 HU) and its capability to detect ACS were evaluated. Results were compared with laboratory findings. RESULTS: MPD was detected in 29 of 32 ACSs. The sensitivity, specificity, and positive and negative predictive values were 91 % (29/32), 93 % (14/15), 97 % (29/30), and 82 % (14/17), respectively. The sensitivities of ST- and non-ST-elevation ACSs were 89 % (16/18) and 93 % (13/14), respectively, without significant difference (P > 0.99). Of the CT-detectable ACS, non-ST-elevation on the electrocardiogram and a normal creatine kinase-myocardial band were observed in 41 % (12/29) and 24 % (7/29), respectively. CONCLUSION: ACS is highly detectable even using conventional parenchymal phase CT imaging. Therefore, even when CT is non-gating, radiologists should carefully evaluate the heart to avoid overlooking ACS.

    DOI: 10.1007/s11604-016-0527-5

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    Other Link: http://link.springer.com/article/10.1007/s11604-016-0527-5/fulltext.html

  • Analysis of decrease in lung perfusion blood volume with occlusive and non-occlusive pulmonary embolisms Reviewed International journal

    Yohei Ikeda, Norihiko Yoshimura, Yoshiro Hori, Yosuke Horii, Hiroyuki Ishikawa, Motohiko Yamazaki, Yoshiyuki Noto, Hidefumi Aoyama

    European Journal of Radiology   83 ( 12 )   2260 - 2267   2014.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    PURPOSE: The aim of this study was to determine if lung perfusion blood volume (lung PBV) with non-occlusive pulmonary embolism (PE) differs quantitatively and visually from that with occlusive PE and to investigate if lung PBV with non-occlusive PE remains the same as that without PE. MATERIALS AND METHODS: Totally, 108 patients suspected of having acute PE underwent pulmonary dual-energy computed tomography angiography (DECTA) between April 2011 and January 2012. Presence of PE on DECTA was evaluated by one radiologist. Two radiologists visually evaluated the PE distribution (segmental or subsegmental) and its nature (occlusive or non-occlusive) on DECTA and classified perfusion in lung PBV as "decreased," "slightly decreased," and "preserved". Two radiologists used a lung PBV application to set a region of interest (ROI) in the center of the lesion and measured HU values of an iodine map. In the same slice as the ROI of the lesion and close to the lesion, another ROI was set in the normal perfusion area without PE, and HUs were measured. The proportion of lesions was compared between the occlusive and non-occlusive groups. HUs were compared among the occlusive, non-occlusive, and corresponding normal groups. RESULTS: Twenty-five patients had 80 segmental or subsegmental lesions. There were 37 and 43 lesions in the occlusive and non-occlusive groups, respectively. The proportion of decreased lesions was 73.0% (27/37) in the occlusive group, while that of preserved lesions in the non-occlusive group was 76.7% (33/43). There was a significant difference in the proportion of lesions (P<0.001) between the two groups. HUs of the iodine map were significantly higher in the non-occlusive group than in the occlusive group (33.8 ± 8.2 HU vs. 11.9 ± 6.1 HU, P<0.001). There was no significant difference in HUs for the entire lesion between the non-occlusive (33.8 ± 8.2 HU) and corresponding normal group (34.5 ± 6.8 HU; P=0.294). CONCLUSION: Iodine perfusion tended to be visually and quantitatively preserved in lungs with nonocclusive PE. Lung PBV is required to evaluate pulmonary blood flow.

    DOI: 10.1016/j.ejrad.2014.08.015

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  • Where is the most common site of DVT? Evaluation by CT venography Reviewed

    Norihiko Yoshimura, Yoshiro Hori, Yosuke Horii, Toru Takano, Hiroyuki Ishikawa, Hidefumi Aoyama

    Japanese Journal of Radiology   30 ( 5 )   393 - 397   2012.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    PURPOSE: Our aim was to clarify the common site of deep venous thrombosis (DVT) in patients suspected of having pulmonary embolism using computed tomography pulmonary angiography with computed tomography venography (CTV). MATERIALS AND METHODS: We evaluated 215 patients. For all studies, 100 ml of 370 mg I/ml nonionic contrast material was administered. CTV were scanned with helical acquisition starting at 3 min in four-slice multidetector-row computed tomography (MDCT) or 5 min in 64-MDCT after the start of contrast material injection. The site of DVT was divided into iliac vein, femoral vein, popliteal vein, or calf vein. Calf vein was divided into muscular (soleal and gastrocnemius) and nonmuscular (anterior/posterior tibial and peroneal) veins. The 2 × 2 chi-square test was used. RESULTS: One hundred and thirty-seven patients showed DVT; the muscular calf vein was more prevalent than other veins (P < 0.01). CONCLUSIONS: Our study showed that the most common site of DVT was the muscular calf vein.

    DOI: 10.1007/s11604-012-0059-6

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    Other Link: http://link.springer.com/article/10.1007/s11604-012-0059-6/fulltext.html

  • Relationship between Heart Rate and Optimal Reconstruction Phase in Dual-source CT Coronary Angiography Reviewed International journal

    Yosuke Horii, Norihiko Yoshimura, Yoshiro Hori, Toru Takano, Shoichi Inagawa, Kohei Akazawa, Hidefumi Aoyama

    Academic Radiology   18 ( 6 )   726 - 730   2011.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    RATIONALE AND OBJECTIVES: To evaluate reconstruction image quality at the systolic and diastolic cardiac phases and determine the optimal phase for reconstruction according to heart rate when using dual-source computed tomography (CT) with 75 ms temporal resolution. MATERIALS AND METHODS: We retrospectively reviewed the CT datasets of 35 patients with regular heartbeats who underwent coronary CT angiography. Images were reconstructed in 2% steps between 32 and 78% of the beat-to-beat interval. Two experienced radiologists determined the reconstruction interval with the fewest motion artifacts and the motion score of each vessel for the systolic and diastolic phases. Subgroup analysis was performed in patients having heart rates of <70, 70-80, and >80 beats per minute (bpm). RESULTS: In the subgroup with heart rates of <70 bpm, the diastolic phase reconstruction image quality was significantly better than for the systolic phase (P < .01). In the 70-80 bpm and >80 bpm subgroups, no significant difference was observed. In the diastolic phase, the image quality of the <70 bpm subgroup was significantly better than for the >80 bpm subgroup (P < .05). In all systolic phase subgroups and other diastolic phase subgroups, no significant difference was observed. CONCLUSIONS: Using a DSCT scanner with 75 ms temporal resolution, reconstruction at the diastolic phases should be used for patients with heart rates <70 bpm. For heart rates >70 bpm, larger studies are necessary to determine whether reconstruction at the systolic, diastolic, or both phases should be used.

    DOI: 10.1016/j.acra.2011.01.012

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  • Correlation between the site of pulmonary embolism and the extent of deep vein thrombosis: evaluation by computed tomography pulmonary angiography and computed tomography venography Reviewed

    Yosuke Horii, Norihiko Yoshimura, Yoshiro Hori, Satoshi Takaki, Toru Takano, Shoichi Inagawa, Hidefumi Aoyama

    Japanese Journal of Radiology   29 ( 3 )   171 - 176   2011.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    PURPOSE: The aim of this study was to evaluate the relation between the sites of pulmonary embolism (PE) and deep vein thrombosis (DVT) by computed tomography pulmonary angiography (CTPA) and CT venography (CTV) of the pelvis and lower extremities. MATERIALS AND METHODS: We retrospectively reevaluated CTPA-CTV data sets for 227 consecutive patients suspected of having a PE. The PEs were divided into proximal (located at the lobar artery or proximal to it) and distal groups. DVTs were divided into proximal (located above the knee) and distal groups. Cohen's kappa statistic and chi-squared tests were performed. RESULTS: The incidence of PE was significantly higher in patients with a proximal DVT than with a distal DVT (P < 0.01). In patients with a proximal DVT, the incidence of proximal PE was significantly higher than that of distal PE (P < 0.05). In patients with a proximal DVT, the incidence of PE was significantly higher in patients with a right-side DVT than with a left-side DVT (P < 0.05). CONCLUSION: Proximal PEs were correlated with proximal DVTs. Patients with a proximal DVT tended to have a PE, especially with a right-proximal DVT. Hence, the presence of a right-proximal DVT has the potential for serious complications, and carefully diagnosis is required for PE and DVT.

    DOI: 10.1007/s11604-010-0533-y

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    Other Link: http://link.springer.com/article/10.1007/s11604-010-0533-y/fulltext.html

  • Comparison of magnetic resonance imaging with transthoracic echocardiography in the diagnosis of ventricular septal defect-associated coronary cusp prolapse Reviewed

    Norihiko Yoshimura, Yoshiro Hori, Yousuke Horii, Hiroshi Suzuki, Satoshi Hasegawa, Masashi Takahashi, Hiroshi Watanabe

    Journal of Magnetic Resonance Imaging   32 ( 5 )   1099 - 1103   2010.11

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/jmri.22370

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  • Multidetector computed tomography venography: optimum dose of contrast material Reviewed

    Yoshiro Hori, Norihiko Yoshimura, Yosuke Horii, Toru Takano

    Japanese Journal of Radiology   28 ( 5 )   335 - 339   2010.6

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    DOI: 10.1007/s11604-010-0428-y

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Research Projects

  • 児童虐待に対応するための小児死後CTの至適条件、死後変化、診断の標準化の検討

    Grant number:20H01654

    2020.4 - 2025.3

    System name:科学研究費助成事業

    Research category:基盤研究(B)

    Awarding organization:日本学術振興会

    高橋 直也, 的場 光太郎, 成田 啓廣, 高塚 尚和, 舟山 一寿, 石川 浩志, 堀井 陽祐

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    Grant amount:\9360000 ( Direct Cost: \7200000 、 Indirect Cost:\2160000 )

    1)小児死後CTの至適条件の検討について。新生児の体格とX線吸収値を模した新生児ファントムを新潟大学医学部法医学教室の16列DualエネルギーMDCTで撮像して得られたCT画像の画質を検討した。CTでは管電流をあげると良好な画像が得られる。被曝の影響を考慮する必要がない遺体の場合、臨床で用いられない高い管電流を使用することが可能であるが、必要以上の管電流を使用すると、機器の負担が増える。複数の管電流を用いて得られた頭部CT画像に、計算ソフトウェアを用いて作成した仮想模擬病変を挿入し、病変の検出能を検討した。経験豊富な2名の放射線科医が、仮想模擬病変が挿入されたCT画像を観察し、この病変が検出できるかどうかを判断し、微細病変の検出に必要な最低限の撮像条件を明らかにした。今後は、小児ファントムを用いて、同様の撮像実験、病変検出能の検討を行い、体格の異なる小児におけるCTの至適条件を検討する予定である。
    2)小児死後CTの画像収集について。2-1)2021年度に新潟大学法医学教室で死後CT検査が行われた小児は4例であった。このうち2例で解剖が行われ、体内の状態と死因についての結果が得られた。解剖が行われた症例については死後CTの画像所見と解剖における実際の所見を比較検討が可能であった。今後は、症例を蓄積し、死後画像所見における死因究明、死後変化について、さらなる検討を行う。2-2)新潟大学放射線医学教室の協力のもと、関連病院において小児死後CT画像の症例の提供を依頼した。各病院の倫理審査委員会で審議を行っていただき、症例提供の手続きを行った。関連病院から、2020年4月から2025年3月までの症例を提供していただき、死後CT所見における死後変化や死因究明の検討を行う。

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  • 逐次近似法再構成冠動脈CTが臨床転帰に与える影響に関する多施設無作為化比較試験

    Grant number:20K07988

    2020.4 - 2024.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    大田 英揮, 後岡 広太郎, 河野 淳, 西井 達矢, 北川 覚也, 城戸 輝仁, 山田 祥岳, 富澤 信夫, 真鍋 徳子, 尾田 済太郎, 立神 史稔, 堀井 陽祐

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    近年,CT装置の発展に伴い,従来法であるフィルター逆投影(FBP法)より低被曝で撮像できる,逐次近似法(IR法)を用いた冠動脈CT検査が臨床に導入されてきた.しかし,患者の臨床転帰に対する影響については,撮像法を比較検討したデータが不足している.
    本研究は,IR法がFBP法と比較して,患者の短期臨床転帰を有意に変えることがないことを明らかにするための,国内多施設が参加する無作為化比較試験である.本研究により「IR法は,患者の短期臨床転帰を変えることなく,冠動脈CTの低被曝化を可能である」ことを示し,低被曝CT検査の標準化を図ることができる.
    本研究では狭心症患者を対象とし,従来の方法であるフィルター逆投影法を用いた冠動脈CT検査と比べた場合の,逐次近似再構成法を応用した低被曝冠動脈CT検査について,以下の2 点を国内多施設で前向きに評価する.
    1.登録から90 日内に,侵襲的カテーテル検査(ICA; invasive coronary angiography)を行い,有意な狭窄病変を認めなかった患者の割合を主要評価項目とし,低被曝冠動脈CTの診療への影響を評価すること.
    2.逐次近似再構成法を応用した低被曝冠動脈CT検査が画像解析法に与える影響について,臨床的に有益な情報を発信すること.
    2021年度は,統括施設の東北大学及び,分担施設で実施許可を取得し,各施設で症例登録を行った.症例登録を継続中である.

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  • 災害時や在宅ケア用の下肢静脈塞栓症リスク自動評価ツールの開発

    Grant number:20K11068

    2020.4 - 2023.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    近藤 世範, 内山 美枝子, 吉村 宣彦, 堀井 陽祐

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    令和3年度は、実験-2「下肢静脈エコー画像における静脈領域の自動抽出」と実験-5「下肢静脈エコー動画像から診断に適した断面画像の自動取得」に取り組むために、前年度に申請した倫理申請の承認後に、ボランティアを募り健常者の下肢静脈エコー画像取得を実施した。成人20名分の膝窩静脈のエコー動画像を携帯型エコー(シグマック社製ポケットエコーMiruco)と設置型エコー(コニカミノルタ社製SONIMAGE HS1)を用いてそれぞれ撮像した。エコー動画像をフレーム分割し、46,338 枚(携帯型エコー)と128,494 枚(設置型エコー)のエコー画像を獲得した。これらのエコー画像を対象画像として、実験-5を実施した。静脈の写り具合(診断に適している具合)によって、各画像をexcellent、average、poorの3 つに目視で分類し教師データとした。全対象画像を7:3 の割合で訓練データとテストデータに分割して、事前学習済みのディープラーニングモデルの1つであるResNet101に適用し訓練・分類を行った。分類精度を表すAUC(ROC曲線下面積)は、携帯型エコーと設置型エコーのどちらも0.9前後の良好な値を示した。これにより、DVT 診断に適した下肢静脈エコー断面像を自動取得できる可能性が示唆された。
    実験-2については、教師データ(静脈領域の設定)を作成中であり、次年度において続けて実施する予定である。また、実験-3「下肢静脈エコー画像における正常静脈と血栓を伴う静脈の自動分類」および実験-4「血栓を伴う下肢静脈エコー画像からのDVT発症リスクの予測」を次年度実施するために、血栓を伴う下肢静脈エコー画像取得に向けて、倫理承認手続きを申請し承認を得た。承認後、30症例分の血栓を伴う下肢静脈エコー画像を収集し、実験-3と実験-4に向けて、データ整理・準備を進めた。

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Teaching Experience

  • 臨床医学講義(集中)

    2022
    Institution name:新潟大学

  • 臓器別講義・演習III

    2021
    Institution name:新潟大学

  • 統合臨床医学

    2021
    Institution name:新潟大学