Updated on 2026/08/13

写真a

 
NIKKUNI Yutaka
 
Organization
Academic Assembly Institute of Medicine and Dentistry - Assistant Professor
Faculty of Dentistry Department of Dentistry Assistant Professor
Graduate School of Medicine, Dentistry and Health Sciences Medicine and Dentistry Assistant Professor
Title
Assistant Professor
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Degree

  • 博士（歯学） ( 2014.3   新潟大学 )

Research Interests

  • radiomics

  • oral and maxillofacial radiology

  • temporomandibular disorder

  • MRI

  • oral oncology

Research History (researchmap)

  • Niigata University Graduate School of Medical and Dental Sciences   Div. of Oral and Maxillofacial Radiology   Assistant Professor

    2013.6

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Research History

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Assistant Professor

    2026.5

  • Niigata University   Tissue Regeneration and Reconstruction, Oral Life Science, Graduate School of Medical and Dental Sciences   Assistant Professor

    2026.5

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction   Assistant Professor

    2013.6

Professional Memberships

  • JAPANESE SOCIETY FOR ORAL AND MAXILLOFACIAL RADIOLOGY

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  • Japanese Society of Oral Oncology

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  • THE JAPANESE SOCIETY FOR TEMPOROMANDIBULAR JOINT

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  • NIIGATA DENTAL SOCIETY

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Committee Memberships

  • NPO法人日本歯科放射線学会学会   診療ガイドライン委員会  

    2015.4   

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    Committee type：Academic society

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Studying abroad experiences

  • The University of Hong Kong   Honorary Research Associate

    2012.7 - 2012.12

Qualification acquired

  • NPO法人日本歯科放射線学会歯科放射線専門医

 

Papers

  • Evaluation of radiomics-based machine learning models for detection of cervical lymph node metastasis from oral cancer on PET images

    Yutaka Nikkuni, Hideyoshi Nishiyama, Masaki Takamura, Taichi Kobayashi, Marie Soga, Makiko Ike, Kouji Katsura, Takafumi Hayashi

    Journal of Stomatology Oral and Maxillofacial Surgery   102754 - 102754   2026.2

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jormas.2026.102754

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  • Evaluation of the Ability to Predict Subsequent Metastasis of Early Oral Squamous Cell Carcinoma Using PET Radiomics Machine Learning Models

    Yutaka Nikkuni, Hideyoshi Nishiyama, Masaki Takamura, Taichi Kobayashi, Marie Soga, Makiko Ike, Kouji Katsura, Takafumi Hayashi

    Cancers   17 ( 21 )   3573 - 3573   2025.11

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    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Background/Objectives: Oral squamous cell carcinoma (OSCC) carries a risk of late metastasis not only in advanced stages but also in early stages. In this study, we built and tested radiomics-based machine learning (ML) models for predicting the risk of metastasis from early OSCC on 18F-FDG positron emission tomography (PET). Methods: Patients diagnosed with T1 or T2 squamous cell carcinoma who underwent a preoperative 18F-FDG PET-CT examination at a single institution between 2016 and December 2022 were included in this retrospective study. The presence or absence of late cervical lymph node metastasis was confirmed for all patients. Among the radiomics features extracted from the images, we selected those that were useful for predicting late metastasis and used them to create ML models. We then verified the prediction accuracy of the models. Results: A total of 109 subjects were included, of which 31 had late lymph node metastasis and 78 were without metastasis. The most accurate ML model created using radiomics features selected from the subject cases had an area under the curve of 0.977 and accuracy of 87.5%. Conclusions: We confirmed that ML models using radiomics features extracted from PET images can be useful for predicting late metastasis in patients with early-stage OSCC.

    DOI： 10.3390/cancers17213573

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  • Utility of the Apparent Diffusion Coefficient in the Differential Diagnosis of Oral Malignant Lymphoma. International journal

    Hideaki Hirai, Yutaka Nikkuni, Ryota Kobayashi, Tetsuo Kiguchi, Yoshimasa Sumita, Yuko Saito, Atsushi Uenoyama, Akinori Funayama, Kei Tomihara

    Cureus   17 ( 11 )   e97006   2025.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: Malignant lymphoma (ML), a lymphocyte-derived malignancy, is classified into Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). In the oral cavity, NHL is the predominant type. However, diagnosing oral ML is challenging owing to its clinical similarity to other lesions. Diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient (ADC) values may aid in differential diagnosis. Therefore, in the present study, we aimed to evaluate the usefulness of ADC in distinguishing ML from squamous cell carcinoma (SCC) and salivary gland carcinoma (SGC). METHODS: This retrospective study included 11 patients with ML, 35 with SCC, and 19 with SGC treated at our institution between 2012 and 2022. Clinical data and ADC values were analyzed, and magnetic resonance imaging was performed using a 3.0 T scanner. RESULTS: Clinical assessment alone frequently resulted in misclassification of ML cases, with most cases initially suspected of having benign or other malignant tumors. ML demonstrated markedly lower ADC values (mean 0.67 ± 0.13 × 10⁻3 mm2/s; range 0.45-0.87) than SCC (1.21 ± 0.14) and SGC (1.30 ± 0.27) (both P < 0.0001), with minimal overlap between the groups. An ADC cutoff of 0.87 × 10⁻3 mm2/s identified ML with 100% sensitivity and 98.2% specificity (area under the curve: 0.99), indicating a strong diagnostic differentiation from carcinoma cases. CONCLUSION: ADC assessment may facilitate early suspicion of oral ML and help clinicians in prioritizing it within the differential diagnosis. Integrating ADC values into the diagnostic workflow could facilitate early recognition and more appropriate biopsy strategies, thus supporting timely management.

    DOI： 10.7759/cureus.97006

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  • Evaluation of factors affecting depth of invasion measurement in tongue squamous cell carcinoma using intraoral ultrasonography

    Masaki Takamura, Taichi Kobayashi, Yutaka Nikkuni, Kouji Katsura, Manabu Yamazaki, Jun-ichi Tanuma, Takafumi Hayashi

    Dentomaxillofacial Radiology   55 ( 1 )   80 - 87   2025.9

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    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    Objective

    Intraoral ultrasonography (US) is known for its high accuracy in evaluating the depth of invasion (DOI) in tongue squamous cell carcinoma (SCC). However, measurement discrepancies, such as overestimation or underestimation, can occur in certain cases. This study aimed to identify factors affecting the measurement accuracy of intraoral US.

    Methods

    A total of 96 cases were included in this study. Patients who underwent imaging diagnosis for primary tongue SCC by oral and maxillofacial radiologists, followed by surgical resection by oral surgeons at our institution between April 2014 and March 2022, were included in the study. Cases were classified according to their clinical and histopathological characteristics, including clinical growth pattern, maximum pathological tumour diameter, pathological T classification, and pattern of invasion (Yamamoto-Kohama classification). Measurement accuracy was evaluated using Spearman’s rank correlation coefficient and Bland-Altman analysis.

    Results

    A total of 76 cases were analysed. Intraoral US demonstrated high diagnostic accuracy across various tumour characteristics. However, greater DOI and larger maximum tumour diameter were associated with increased variability in measurements. Exophytic lesions were more likely to be overestimated, whereas lesions with diffuse infiltration tended to be underestimated.

    Conclusion

    Although intraoral US provides high accuracy in the preoperative evaluation of tongue SCC, clinicians should be aware of specific tumour characteristics that may influence measurement precision, leading to potential overestimation or underestimation.

    DOI： 10.1093/dmfr/twaf062

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    Other Link： https://academic.oup.com/dmfr/article-pdf/55/1/80/64237135/twaf062.pdf

  • 再発のみられた単純性骨嚢胞様の空洞化を伴ったセメント質骨性異形成症の1例

    竹内 涼子, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 長谷部 大地, 新國 農, 林 孝文, 丸山 智, 田沼 順一, 船山 昭典

    日本口腔科学会雑誌   74 ( 2 )   141 - 141   2025.7

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    Language：Japanese   Publisher：(NPO)日本口腔科学会  

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  • Prediction of Histological Grade of Oral Squamous Cell Carcinoma Using Machine Learning Models Applied to 18F-FDG-PET Radiomics. Reviewed International journal

    Yutaka Nikkuni, Hideyoshi Nishiyama, Takafumi Hayashi

    Biomedicines   12 ( 7 )   2024.6

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    The histological grade of oral squamous cell carcinoma affects the prognosis. In the present study, we performed a radiomics analysis to extract features from 18F-FDG PET image data, created machine learning models from the features, and verified the accuracy of the prediction of the histological grade of oral squamous cell carcinoma. The subjects were 191 patients in whom an 18F-FDG-PET examination was performed preoperatively and a histopathological grade was confirmed after surgery, and their tumor sizes were sufficient for a radiomics analysis. These patients were split in a 70%/30% ratio for use as training data and testing data, respectively. We extracted 2993 radiomics features from the PET images of each patient. Logistic Regression (LR), Support Vector Machine (SVM), Random Forest (RF), Naïve Bayes (NB), and K-Nearest Neighbor (KNN) machine learning models were created. The areas under the curve obtained from receiver operating characteristic curves for the prediction of the histological grade of oral squamous cell carcinoma were 0.72, 0.71, 0.84, 0.74, and 0.73 for LR, SVM, RF, NB, and KNN, respectively. We confirmed that a PET radiomics analysis is useful for the preoperative prediction of the histological grade of oral squamous cell carcinoma.

    DOI： 10.3390/biomedicines12071411

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  • Comparing the Diagnostic Accuracy of Ultrasonography, CT, MRI, and PET/CT in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma Reviewed

    Masaki Takamura, Yutaka Nikkuni, Takafumi Hayashi, Kouji Katsura, Hideyoshi Nishiyama, Manabu Yamazaki, Satoshi Maruyama, Jun-ichi Tanuma

    Biomedicines   11 ( 12 )   3119 - 3119   2023.11

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    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    (1) Background: In oral cancer staging, ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) with positron emission tomography/computed tomography (PET/CT) are routinely used in clinical practice. The present study is a retrospective examination of the diagnostic accuracy of cervical lymph node metastasis using US, CT, MRI, and PET/CT, with histopathological diagnosis as a reference, to compare the different diagnostic imaging modalities. (2) Methods: The participants included 16 patients with oral squamous cell carcinoma who underwent US-, CT-, MRI-, and PET/CT-based preoperative diagnostic imaging and simultaneous primary lesion resection and neck dissection, including 82 level regions and 424 lymph nodes. We compared the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of each imaging modality based on the imaging results and the pathology results of metastasis. (3) Results: Of the four diagnostic imaging modalities, PET/CT exhibited the highest sensitivity but the lowest specificity and accuracy. US, CT, and MRI had high specificities. Comparing each level region and lymph node showed that differences were observed in PET/CT. (4) Conclusions: PET/CT to diagnose lymph node metastasis requires a comprehensive evaluation because it produces more false positives than other diagnostic imaging modalities. Using US, CT, and MRI, which have excellent spatial resolution, improves diagnostic accuracy at the lymph node level.

    DOI： 10.3390/biomedicines11123119

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  • 下顎偏位を呈した片側性下顎頭過形成の1例 Reviewed

    齋藤 大輔, 須田 大亮, 新国 農, 林 孝文, 小林 正治

    日本顎関節学会雑誌   35 ( Suppl. )   126 - 126   2023.7

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    Language：Japanese   Publisher：(一社)日本顎関節学会  

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  • A case of temporomandibular joint ankylosis due to SAPHO syndrome

    Atsushi UENOYAMA, Yasumitsu KODAMA, Hisashi OHNUKI, Yutaka NIKKUNI, Hideyoshi NISHIYAMA, Ritsuo TAKAGI

    Japanese Journal of Oral and Maxillofacial Surgery   68 ( 9 )   370 - 377   2022.9

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    Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

    DOI： 10.5794/jjoms.68.370

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  • Histogram analysis of 18F-FDG PET imaging SUVs may predict the histologic grade of oral squamous cell carcinoma. Reviewed International journal

    Yutaka Nikkuni, Hideyoshi Nishiyama, Takafumi Hyayashi

    Oral surgery, oral medicine, oral pathology and oral radiology   134 ( 2 )   254 - 261   2022.8

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: We tested the hypothesis that histogram analysis parameters of standardized uptake values (SUVs) obtained preoperatively using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) are significantly influenced by differences in metabolic capacity due to the histologic grade of oral squamous cell carcinoma (OSCC). STUDY DESIGN: The study included 62 patients who were clinically diagnosed with OSCC and received surgical treatment after an 18F-FDG PET examination. Histogram analysis was performed using all voxels contained in the tumor area of each patient with an SUV ≥2.5. The histogram parameters calculated were the mean and standard deviation of SUVs, maximum SUV, metabolic tumor volume, skewness, and kurtosis. Statistical analyses were performed using a Mann-Whitney U test to calculate the significance of differences in these parameters between groups with well- and moderately- or poorly-differentiated tumors. Statistical significance was assumed at P < .05. RESULTS: Only a comparison of kurtosis in the histogram showed a significant difference between the well- and moderately/poorly-differentiated tumors (P = .0294). CONCLUSIONS: The distribution of metabolic capacity in oral squamous cell carcinoma tissues revealed on an 18F-FDG PET examination may help identify the histologic grade. This finding may provide valuable information for determining the subsequent treatment plan and predicting disease prognosis.

    DOI： 10.1016/j.oooo.2022.03.005

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  • 下顎歯肉部転移性腫瘍を契機に診断に至った膵癌の1例 Reviewed

    須田 大亮, 船山 昭典, 齋藤 大輔, 新國 農, 丸山 智, 林 孝文, 田沼 順一, 小林 正治

    日本口腔科学会雑誌   71 ( 2 )   159 - 159   2022.7

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    Language：Japanese   Publisher：(NPO)日本口腔科学会  

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  • A phantom study regarding the formation mechanism of mucosal epithelial echo on intraoral ultrasonography Reviewed

    Taichi Kobayashi, Takafumi Hayashi, Masaki Takamura, Marie Soga, Yutaka Nikkuni, Kouji Katsura

    Oral Science International   19 ( 3 )   147 - 153   2022.1

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/osi2.1129

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1129

  • 関節隆起部の骨蜂巣内に炎症性変化が波及した変形性顎関節症の1例 Reviewed

    池田 順行, 上野山 敦士, 高嶋 真樹子, 荒井 良明, 新國 農, 西山 秀昌, 高木 律男

    新潟歯学会雑誌   51 ( 2 )   95 - 99   2021.12

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    Language：Japanese   Publisher：新潟歯学会  

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  • Spindle cell squamous cell carcinoma exhibiting prominent neutrophil phagocytosis: a case report. Reviewed International journal

    Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Yoshimasa Sumita, Yuji Katsumi, Yutaka Nikkuni, Takafumi Hayashi, Jun-Ichi Tanuma

    Journal of medical case reports   15 ( 1 )   438 - 438   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Spindle cell squamous cell carcinoma is an uncommon variant of squamous cell carcinoma; its diagnosis is sometimes challenging because it histopathologically resembles neoplastic or reactive spindle cell lesions of mesenchymal origins. Here, we report a rare case of spindle cell squamous cell carcinoma exhibiting prominent neutrophil phagocytosis. CASE PRESENTATION: A 69-year-old Japanese man presented with pain and a polypoid mass on the lower left gingiva. He had received chemoradiotherapy for squamous cell carcinoma of the buccal mucosa 15 years prior to this consultation. In addition, he was treated for mandibular osteonecrosis 6 years after chemoradiotherapy without evidence of cancer recurrence. A biopsy revealed atypical spindle or pleomorphic cells scattered in the edematous and fibrin-rich stroma; however, no malignant squamous components were apparent. These atypical cells frequently contained neutrophils within their cytoplasm that formed cell-in-cell figures. Immunohistochemically, the atypical cells were negative for cytokeratins, epithelial membrane antigen, and E-cadherin, but positive for p63, vimentin, and p53. Although these findings suggested spindle cell squamous cell carcinoma, it was difficult to reach a definitive diagnosis. Based on a clinical diagnosis of a malignant tumor, the patient underwent a hemimandibulectomy. The surgically resected specimen had a typical spindle cell squamous cell carcinoma histology consisting of biphasic spindle cells and conventional squamous cell carcinoma components. Moreover, the surgical specimen also exhibited spindle tumor cells that frequently included neutrophils, around which intense staining for lysosomal-associated membrane protein 1 and cathepsin B was observed. This suggested that the cell-in-cell figures represent active neutrophil phagocytosis by tumor cells, and not emperipolesis. CONCLUSION: The presence of neutrophil phagocytosis may be a potent indicator of malignancy.

    DOI： 10.1186/s13256-021-03066-z

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  • A comparative study between CT, MRI, and intraoral US for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma Reviewed

    Masaki Takamura, Taichi Kobayashi, Yutaka Nikkuni, Kouji Katsura, Manabu Yamazaki, Satoshi Maruyama, Jun-ichi Tanuma, Takafumi Hayashi

    Oral Radiology   38 ( 1 )   114 - 125   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    <title>Abstract</title><sec>
    <title>Objectives</title>
    This study aimed to clarify the accuracy of intraoral ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) in preoperative image depth of invasion (DOI) measurement of T1/T2 tongue cancer through comparison with histopathological measurements.


    </sec><sec>
    <title>Methods</title>
    Imaging of the primary lesions was performed at our hospital; the lesions were classified into T1 and T2 based on the 8th edition of the AJCC/UICC, and surgery performed. There was histopathological confirmation of lesions as squamous cell carcinoma in 48 patients with tongue cancer. T3 and T4 cases, cases in which preoperative chemotherapy and radiation therapy were performed, and cases where biopsy was performed before imaging were excluded. The radiological DOI in US, CT, and MRI and the histopathological DOI as base were comparatively investigated and statistical analyses were performed by Bland–Altman analysis and Spearman's rank correlation coefficient.


    </sec><sec>
    <title>Results</title>
    Bland–Altman analysis showed that the US radiological DOI was overestimated by an average of 0.2 mm compared to the histopathological DOI, while CT and MRI radiological DOI were overestimated by an average of 2–3 mm. The comparison of CT and MRI revealed that the difference between the MRI and histopathological DOI, as well as the 95% limit of agreement, were smaller than those of the CT radiological DOI.


    </sec><sec>
    <title>Conclusions</title>
    US is the most accurate preoperative diagnostic tool for T1 and T2 squamous cell carcinoma; CT and MRI tend to have an overestimation of about 2–3 mm and so caution is required.


    </sec>

    DOI： 10.1007/s11282-021-00533-7

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    Other Link： https://link.springer.com/article/10.1007/s11282-021-00533-7/fulltext.html

  • 深層学習システムの画像認識過程を人間が理解可能な抽象化過程に近づけることは可能か?

    西山 秀昌, 高村 真貴, 曽我 麻里恵, 小林 太一, 新國 農, 池 真樹子, 勝良 剛詞, 林 孝文

    歯科放射線   61 ( 増刊 )   71 - 71   2021.5

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  • Regarding the acoustic coupling medium for the estimation of the depth of invasion in tongue squamous cell carcinoma on intraoral sonography with special reference to the interpretation of normal mucosal structure: A literature review Reviewed

    Takafumi Hayashi, Masaki Takamura, Taichi Kobayashi, Yutaka Nikkuni, Kouji Katsura

    Oral Science International   2021.4

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/osi2.1110

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1110

  • 口底部に発生した孤立性神経線維腫の1例 Reviewed

    野澤 舞, 三上 俊彦, 船山 昭典, 齋藤 大輔, 須田 大亮, 新美 奏恵, 阿部 達也, 田沼 順一, 新國 農, 西山 秀昌, 林 孝文, 小林 正治

    日本口腔診断学会雑誌   34 ( 1 )   73 - 74   2021.2

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  • 早期舌癌の術前DOI計測におけるCT、MRI、口腔内USの比較 Reviewed

    高村 真貴, 小林 太一, 新國 農, 勝良 剛詞, 山崎 学, 丸山 智, 田沼 順一, 林 孝文

    新潟歯学会雑誌   50 ( 2 )   107 - 107   2020.12

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    Language：Japanese   Publisher：新潟歯学会  

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  • 口底部に発生した孤立性神経線維腫の1例

    野澤 舞, 三上 俊彦, 船山 昭典, 齋藤 大輔, 須田 大亮, 新美 奏恵, 阿部 達也, 田沼 順一, 新國 農, 西山 秀昌, 林 孝文, 小林 正治

    日本口腔内科学会雑誌   26 ( 2 )   121 - 122   2020.12

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  • 下顎埋伏智歯に関連した原発性骨内癌の1例

    小林 亮太, 高木 律男, 新國 農, 丸山 智, 山崎 学, 上野山 敦士, 田沼 順一, 林 孝文, 児玉 泰光

    日本口腔腫瘍学会誌   32 ( 4 )   243 - 250   2020.12

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  • 下顎水平埋伏智歯の歯冠部に生じた下顎骨中心性癌の1例

    小林 亮太, 児玉 泰光, 新國 農, 山崎 学, 黒川 亮, 上野山 敦士, 笠原 映, 田沼 順一, 林 孝文, 高木 律男

    日本口腔科学会雑誌   69 ( 2 )   99 - 99   2020.7

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  • 舌上皮性異形成および上皮内癌と診断された病変の診断および治療の検討 Reviewed

    新美 奏恵, 船山 昭典, 丸山 智, 勝良 剛詞, 新國 農, 田沼 順一, 林 孝文, 小林 正治

    日本口腔診断学会雑誌   33 ( 1 )   126 - 126   2020.2

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  • Quantitative evaluation of elasticity of lower orbicularis oris muscle during the lip closing measurement using sonographic elastography. Reviewed International journal

    Sachiko Hayashi-Sakai, Taichi Kobayashi, Makoto Sakamoto, Takafumi Hayashi, Yusuke Morise, Yutaka Nikkuni, Masaki Takamura, Jun Sakai, Junko Shimomura-Kuroki, Makiko Ike, Hideyoshi Nishiyama

    Bio-medical materials and engineering   31 ( 6 )   361 - 371   2020

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Lip closing functions have never been evaluated from the viewpoint of elastic properties. OBJECTIVES: The purpose of the present study was to investigate the behavior of the lower orbicularis oris muscle during a button-pull exercise to measure lip closing force and quantitatively evaluate its elastic properties using sonographic elastography. METHODS: Appropriate compression loads for elastography were randomly measured on one of three types of acoustic couplers on three examiners. Compression tests were performed on three types of acoustic couplers within the appropriate compression load. Using the acoustic coupler with the lowest elastic modulus, the strain ratio of the lower orbicularis oris muscle during lip closing was measured, and elastography was performed on six males under tension loads of 0-8 N. RESULTS: The intraclass correlation coefficient (1, 3) for the tension load of 0 N was 0.81. Elastography showed that the strain ratio values increased significantly (p < 0.05) as the tension load increased. CONCLUSIONS: Combining the data obtained from lip closing test devices and sonographic elastography enabled the muscle performance to be evaluated objectively and accurately.

    DOI： 10.3233/BME-201101

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  • 舌上皮性異形成および上皮内癌と診断された病変の診断および治療の検討

    新美 奏恵, 船山 昭典, 丸山 智, 勝良 剛詞, 新國 農, 田沼 順一, 林 孝文, 小林 正治

    日本口腔内科学会雑誌   25 ( 2 )   116 - 116   2019.12

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  • 当科における顎関節開放手術の臨床的検討

    池田 順行, 大貫 尚志, 齋藤 太郎, 上野山 敦士, 北村 厚, 中谷 暢佑, 高嶋 真樹子, 河村 篤志, 山崎 裕太, 荒井 良明, 新國 農, 西山 秀昌, 林 孝文, 高木 律男

    日本顎関節学会雑誌   31 ( Suppl. )   142 - 142   2019.7

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  • 顎関節パノラマ4分割撮影にて関節円板の石灰化が疑われた症例

    西山 秀昌, 新國 農, 池田 順行, 荒井 良明, 高木 律男, 林 孝文

    日本顎関節学会雑誌   31 ( Suppl. )   151 - 151   2019.7

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  • Evaluation of permanent and primary enamel and dentin mineral density using micro-computed tomography. Reviewed

    Hayashi-Sakai S, Sakamoto M, Hayashi T, Kondo T, Sugita K, Sakai J, Shimomura-Kuroki J, Ike M, Nikkuni Y, Nishiyama H

    Oral Radiology   35 ( 1 )   29 - 34   2019.1

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    OBJECTIVES: The present study was performed to investigate the mineral density distribution in enamel and dentin for both permanent and primary teeth and to establish the standard density per tooth type using micro-computed tomography (CT). METHODS: Fifty-seven extracted human teeth (37 permanent, 20 primary) were evaluated in the present study. The enamel and dentin mineral densities in the extracted teeth were measured using micro-CT. Cubic regression curves were used to determine the mineral density distribution in the enamel and dentin for each tooth type. RESULTS: The mean values, distributions, and regression equations of the mineral densities were obtained. The mean mineral density values for permanent enamel and dentin were significantly higher than those for their primary counterparts for each tooth type. CONCLUSIONS: In the present study, we demonstrated the distribution of mineral density in sound enamel and dentin and attempted to determine the standard mineral density for each tooth type using micro-CT. The mineral density distributions found in this study contribute to our understanding of the mechanical properties of enamel and dentin. A positive correlation suggests that the systemic bone mineral density could be predicted based on the analysis of exfoliated teeth, such as in patients with hypophosphatasia. The present results may be useful in establishing a numerical standard for the mechanism involved in root fracture and for early detection of root fracture risk.

    DOI： 10.1007/s11282-018-0315-2

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  • 顎関節開放手術を行った顎関節円板障害を伴う変形性顎関節症の1例

    池田 順行, 高嶋 真樹子, 河村 篤志, 山崎 裕太, 荒井 良明, 大貫 尚志, 齋藤 太郎, 上野山 敦士, 中谷 暢佑, 新國 農, 西山 秀昌, 高木 律男

    日本歯科心身医学会雑誌   33 ( 2 )   100 - 101   2018.12

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  • The relationship between masseter muscle pain and T2 values in temporomandibular joint disorders. Reviewed International journal

    Nikkuni Y, Nishiyama H, Hyayashi T

    Oral surgery, oral medicine, oral pathology and oral radiology   126 ( 4 )   349 - 354   2018.10

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    OBJECTIVE: Myofascial pain in temporomandibular joint disorders (TMDs) is evoked by various factors, including edematous change. We investigated whether the pain pattern is related to edematous change by using T2 mapping generated by magnetic resonance imaging to detect water content in the tissue. STUDY DESIGN: One hundred and five patients diagnosed with TMDs, with or without unilateral masseter muscle pain, were divided into 6 groups according to their pain experience: pain on compression (23 cases), pain on movement (13 cases), spontaneous pain (4 cases), pain on compression and movement (14 cases), pain on compression and spontaneous pain (2 cases), and no pain (49 cases). Differences in the mean T2 values of the masseter muscle between the group with pain on only one side (5 unilateral pain groups) or pain-free on both the right and left sides (pain-free group) were compared with paired t tests. Significant differences were assumed at P < .05. RESULTS: Significant differences in mean T2 values were found between the painful and pain-free sides in the group with pain on compression. CONCLUSIONS: The findings of edematous change in the masseter muscle of patients with pain on compression may affect treatment planning and lead to investigation of treatment options for myofascial pain in TMDs.

    DOI： 10.1016/j.oooo.2018.06.003

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  • 臨床家のための画像診断CheckPoint 歯科軟組織疾患の超音波画像診断に挑戦する

    林 孝文, 高村 真貴, 小林 太一, 曽我 麻里恵, 新國 農, 勝良 剛詞, 田中 礼

    歯界展望   132 ( 3 )   530 - 540   2018.9

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  • 口腔内超音波走査における粘膜上皮層に関するファントムを用いた基礎的検討

    小林 太一, 林 孝文, 池 真樹子, 新國 農, 勝良 剛詞, 西山 秀昌, 田中 礼

    日本口腔科学会雑誌   67 ( 2 )   119 - 119   2018.7

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  • 顎関節開放手術を行った顎関節円板障害を伴う変形性顎関節症の1例

    池田 順行, 高嶋 真樹子, 河村 篤志, 山崎 裕太, 荒井 良明, 大貫 尚志, 齋藤 太郎, 上野山 敦士, 中谷 暢佑, 新國 農, 西山 秀昌, 高木 律男

    日本顎関節学会雑誌   30 ( Suppl. )   106 - 106   2018.7

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  • Clinical guidelines for dental cone-beam computed tomography Reviewed

    Takafumi Hayashi, Yoshinori Arai, Toru Chikui, Sachiko Hayashi-Sakai, Kazuya Honda, Hiroko Indo, Taisuke Kawai, Kaoru Kobayashi, Shumei Murakami, Masako Nagasawa, Munetaka Naitoh, Eiji Nakayama, Yutaka Nikkuni, Hideyoshi Nishiyama, Noriaki Shoji, Shigeaki Suenaga, Ray Tanaka

    Oral Radiology   34 ( 2 )   89 - 104   2018.5

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    DOI： 10.1007/s11282-018-0314-3

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  • 口腔内超音波検査による舌癌原発巣のDOI(Depth of invasion)はリンパ節転移を予見できるか

    小林 太一, 高村 真貴, 曽我 麻里恵, 新國 農, 勝良 剛詞, 林 孝文

    歯科放射線   58 ( 増刊 )   53 - 53   2018.5

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  • ディープラーニングを用いたデンタル画像のマウント位置学習における特徴量について

    西山 秀昌, 高村 真貴, 小林 太一, 曽我 麻里恵, 坂井 幸子, 新國 農, 勝良 剛詞, 林 孝文

    歯科放射線   58 ( 増刊 )   45 - 45   2018.5

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  • 18FDG PET/CTにおけるSUVヒストグラム分析による口腔扁平上皮癌の組織型予測の検討

    新國 農, 西山 秀昌, 高村 真貴, 小林 太一, 曽我 麻里恵, 坂井 幸子, 池 真樹子, 勝良 剛詞, 林 孝文

    歯科放射線   58 ( 増刊 )   54 - 54   2018.5

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  • 口腔内超音波走査による粘膜上皮層基底部の描出の検討

    小林 太一, 林 孝文, 高村 真貴, 曽我 麻里恵, 坂井 幸子, 池 真樹子, 新國 農, 勝良 剛詞, 西山 秀昌

    新潟歯学会雑誌   47 ( 2 )   126 - 126   2017.12

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  • Clinical significance of intraoral strain elastography for diagnosing early stage tongue carcinoma: a preliminary study Reviewed

    Motoki Shingaki, Yutaka Nikkuni, Kouji Katsura, Nobuyuki Ikeda, Satoshi Maruyama, Ritsuo Takagi, Takafumi Hayashi

    ORAL RADIOLOGY   33 ( 3 )   204 - 211   2017.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11282-016-0269-1

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  • ロボット支援下手術用小型術中用超音波プローブによる口腔内走査の試み

    小林 太一, 曽我 麻里恵, 坂井 幸子, 新國 農, 勝良 剛詞, 林 孝文

    歯科放射線   57 ( 増刊 )   58 - 58   2017.5

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  • シェーグレン症候群の超音波診断基準に関する検討

    小林 太一, 曽我 麻里恵, 坂井 幸子, 中山 美和, 池 真樹子, 新国 農, 勝良 剛詞, 西山 秀昌, 林 孝文

    歯科放射線   56 ( 増刊 )   71 - 71   2016.6

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  • Electron Probe Microanalysis of Exogenous Pigmentation of Oral Mucosa Originating from Dental Alloy: Two Case Reports Reviewed

    Funayama A, Mikami T, Niimi1 K, Kano H, Nikkuni Y, Yamazaki M, Kobayashi T

    Open Journal of Stomatology   2016 ( 6 )   120 - 126   2016.4

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  • Nondestructive Microcomputed Tomography Evaluation of Mineral Density in Exfoliated Teeth with Hypophosphatasia Reviewed International journal

    Sachiko Hayashi-Sakai, Takafumi Hayashi, Makoto Sakamoto, Jun Sakai, Junko Shimomura-Kuroki, Hideyoshi Nishiyama, Kouji Katsura, Makiko Ike, Yutaka Nikkuni, Miwa Nakayama, Marie Soga, Taichi Kobayashi

    Case Reports in Dentistry   2016   4898456 - 4898456   2016

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

    DOI： 10.1155/2016/4898456

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  • 超音波による舌骨の下顎骨との同時動態評価法の試み 口腔内装置の効果判定を目指して

    堀内 悟, 小林 太一, 新垣 元基, 曽我 麻里恵, 中山 美和, 新國 農, 池 真樹子, 田中 礼, 勝良 剛詞, 西山 秀昌, 林 孝文

    新潟歯学会雑誌   45 ( 2 )   115 - 115   2015.12

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  • 口腔内超音波エラストグラフィを用いた舌癌の筋層浸潤診断

    新垣 元基, 新國 農, 勝良 剛詞, 池田 順行, 高木 律男, 林 孝文

    日本口腔科学会雑誌   64 ( 2 )   112 - 112   2015.7

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  • Clinical significance of T2 mapping MRI for the evaluation of masseter muscle pain in patients with temporomandibular joint disorders Reviewed

    Yutaka Nikkuni, Hideyoshi Nishiyama, Takafumi Hayashi

    Oral Radiology   29 ( 1 )   50 - 55   2013.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11282-012-0108-y

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  • 非復位性円板前方転位における円板前方端の可動範囲について

    西山 秀昌, 新国 農, 櫻井 直樹, 荒井 良明, 林 孝文

    日本顎関節学会雑誌   23 ( Suppl. )   97 - 97   2011.7

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  • 非照射型口内法エックス線撮影模型実習システム(特許出願中)の試作

    西山 秀昌, 新国 農, 斎藤 美紀子, 田中 礼, 平 周三, 小山 純市, 勝良 剛詞, 竹内 由一, 山野井 敬彦, 荒井 良明, 林 孝文

    新潟歯学会雑誌   38 ( 1 )   47 - 47   2008.6

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  • 口腔癌の頸部リンパ節転移の診断における組織弾性イメージング（Real-time Tissue ElastographyR）の有用性． Reviewed

    平 周三, 新國 農, 林 孝文, 星名秀行, 新垣 晋

    頭頚部癌   34 ( 4 )   518 - 525   2008

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  • Clinical usefulness of real-time tissue elastography in the evaluation of cervical lymph node metastases in patients with oral cancer Reviewed

    Shuhzou Taira, Yutaka Nikkuni, Takafumi Hayashi, Hideyuki Hoshina, Susumu Shingaki

    Toukeibu Gan   34 ( 4 )   518 - 525   2008

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    DOI： 10.5981/jjhnc.34.518

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MISC

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Presentations

  • 18F-FDG PET/CTにおけるSUVヒストグラム分析による口腔扁平上皮癌の組織型予測の検討．

    新國 農, 西山秀昌, 髙村真貴, 小林太一, 曽我麻里恵, 坂井幸子, 池真樹子, 勝良剛詞, 林 孝文

    日本歯科放射線学会第59回学術大会  2018.5 

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  • Apparent diffusion coefficient map in oral squamous cell carcinoma: a clinical value for the prediction of nodal metastasis. International conference

    Yutaka Nikkuni, Hideyoshi Nishiyama, Takafumi Hayashi, Makiko Ike, Miwa Nakayama

    21th International Congress of Dental and Maxillofacial Radiology  2017.4 

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  • 生検後の経過観察で縮小が見られた脈瘤性骨嚢胞の1例．

    新國 農

    日本歯科放射線学会第19回臨床画像大会および教育研修会  2014.11 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 片側咬筋痛における咬筋T2値差の痛みの種類による検討.

    新國 農, 西山 秀昌, 林 孝文

    第27回日本顎関節学会総会・学術大会  2014.7 

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  • 硬さファントムの組織弾性評価におけるStrain Ratioとせん断弾性波伝播速度の比較検討．

    新國 農, 林 孝文, 有地 淑子

    日本歯科放射線学会第55回総会・学術大会  2014.6 

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  • T2値による外側翼突筋と翼突静脈叢の判別、並びに両者と顎関節症の疼痛との関連性．

    新國 農, 西山 秀昌, 林 孝文

    日本歯科放射線学会第54回総会・学術大会  2013.6 

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  • 顎関節部MRIの応用－痛みを有する咬筋T2値の左右差について

    新國 農, 西山 秀昌, 林 孝文

    第24回一般社団法人日本顎関節学会総会・学術大会  2011.7 

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  • Age-related changes in the T2 values of masseter muscle in patients with TMD. International conference

    Yutaka Nikkuni, Hideyoshi Nishiyama, Takafumi Hayashi

    18th International Congress of Dento-Maxillo-Facial Radiology  2011.5 

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  • 顎関節症患者における咬筋内部でのT2 値領域分布．

    新國 農, 西山 秀昌, 林 孝文

    日本歯科放射線学会第51回学術大会  2010.4 

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  • T2カラーマッピングにて咀嚼筋に異常がみられた顎関節症患者の1例．

    新國 農, 西山 秀昌, 林 孝文

    日本歯科放射線学会第14回臨床画像大会  2009.10 

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  • 下顎に生じた中心性巨細胞修復性肉芽腫の1例．

    新國 農, 西山 秀昌, 林 孝文

    日本歯科放射線学会第49回学術大会  2008.5 

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  • MRIにて側頭筋炎と診断した顎関節症の1例．

    新國 農, 西山 秀昌, 林 孝文

    日本歯科放射線学会第12回臨床画像大会  2007.10 

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Awards

  • 平成26年度NPO法人日本歯科放射線学会学会賞・学術奨励賞

    2014.6   Clinical significance of T2 mapping MRI for the evaluation of masseter muscle pain in patients with temporomandibular joint disorders.

    Yutaka Nikkuni

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Research Projects

  • レディオミクス導入による口腔癌頸部リンパ節節外浸潤(ENE)画像検出システムの開発

    Grant number：25K13204

    2025.4 - 2028.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    新国 農, 西山 秀昌, 阿部 達也, 林 孝文

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Submucosal penetration in intraoral ultrasonography predicts subsequent cervical lymph node metastasis in T1 tongue cancer

    Grant number：25K13183

    2025.4 - 2028.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • The role of muscle assessment for diagnosis of oral hypofunction

    Grant number：24K13211

    2024.4 - 2027.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • バイオイメージングによる顎関節症治療の新たな地平：咬筋性状の高精度精査．

    2018.4 - 2020.3

    System name：Grant-in-Aid for Early-Career Scientists

    Awarding organization：Japan Society for the Promotion of Science

    Yutaka Nikkuni

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  • A novel treatment strategy for early stage tongue carcinoma using intraoral ultrasonography

    Grant number：15K15692

    2015.4 - 2019.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Challenging Exploratory Research

    Awarding organization：Japan Society for the Promotion of Science

    HAYASHI Takafumi

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    Grant amount：\3510000 （ Direct Cost: \2700000 、 Indirect Cost：\810000 ）

    Intraoral strain elastosonography has been proved to be an alternative noninvasive method for diagnosing the early stage tongue carcinoma and evaluating the degree of muscular invasion.
    A normal mucosal layer of tongue, which is required for the definition of depth of invasion in latest T staging of tongue carcinoma, has been clearly demonstrated by using the appropriate acoustic coupling material and high-resolution ultrasound probe.

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  • T2 value of masticator muscles with pain whether there is relation to the autonomic nervous system or not.

    Grant number：23592761

    2011.4 - 2016.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Nishiyama Hideyoshi, NIKKUNI Yutaka, YAMAMURA Kensuke

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    Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）

    T2 value of masseter muscles were higher on painful side based on painless side with temporomandibular disorder. Also there was significant related to oppressive pain with T2 value, but no relation to pain on motion. The reason does not seem to depend on direct tissue damages, because the difference cannot detect on T2 weighted image that will be affected with proton density. It might be influenced by blood flow rates and/or free water ratios in the interstitial fluid. And there were significant differences of T2 value on masticator muscles of patients with trigeminal neuralgia independent on the trigger point, so the pain might effect on blood flow rate and condition of the interstitial fluid path through the autonomic nervous system.

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Teaching Experience

  • 放射線学総論

    2023
    Institution name：新潟大学

  • 臨床予備実習

    2021
    Institution name：新潟大学

  • 口腔インプラント学

    2020
    Institution name：新潟大学

  • 早期臨床実習Ⅱ

    2018
    -
    2019
    Institution name：新潟大学