Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/osi2.1129

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Language：Japanese   Publisher：新潟歯学会  

今回われわれは、関節隆起部の骨蜂巣内に炎症性変化が波及した変形性顎関節症の1例を報告する。症例は52歳の女性で、開口障害と左側顎関節部の疼痛を主訴に当院顎関節治療部を受診した。アプライアンス治療と薬物療法を受けたが疼痛が増悪したため当科を紹介で初診した。開口量は上下顎中切歯間距離で22mmであった。CT像では、左側下顎頭の関節面と関節隆起の後斜面が開閉口時に干渉し、同部の表面皮質骨には吸収像が認められた。MRIでは、左側顎関節円板は前方に転位して復位を認めず、T2強調像にて関節隆起部の骨蜂巣内に広がる高信号領域が認められた。パンピングマニュピレーションにて疼痛と開口障害は一時的に改善したが翌日には症状が再燃した。よって、顎関節開放手術にて、顎関節円板切除、関節隆起整形、高位下顎頭切除を行った。術後は早期より開口練習を行い、生じた咬合の偏位に関しては顎間ゴム牽引と補綴治療で対応した。術後のMRIでは、関節隆起内にみられた高信号は減少していた。術後に疼痛は消失して開口量は34mmを維持し、術後7年で転居のため転院となった。(著者抄録)

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Spindle cell squamous cell carcinoma is an uncommon variant of squamous cell carcinoma; its diagnosis is sometimes challenging because it histopathologically resembles neoplastic or reactive spindle cell lesions of mesenchymal origins. Here, we report a rare case of spindle cell squamous cell carcinoma exhibiting prominent neutrophil phagocytosis. CASE PRESENTATION: A 69-year-old Japanese man presented with pain and a polypoid mass on the lower left gingiva. He had received chemoradiotherapy for squamous cell carcinoma of the buccal mucosa 15 years prior to this consultation. In addition, he was treated for mandibular osteonecrosis 6 years after chemoradiotherapy without evidence of cancer recurrence. A biopsy revealed atypical spindle or pleomorphic cells scattered in the edematous and fibrin-rich stroma; however, no malignant squamous components were apparent. These atypical cells frequently contained neutrophils within their cytoplasm that formed cell-in-cell figures. Immunohistochemically, the atypical cells were negative for cytokeratins, epithelial membrane antigen, and E-cadherin, but positive for p63, vimentin, and p53. Although these findings suggested spindle cell squamous cell carcinoma, it was difficult to reach a definitive diagnosis. Based on a clinical diagnosis of a malignant tumor, the patient underwent a hemimandibulectomy. The surgically resected specimen had a typical spindle cell squamous cell carcinoma histology consisting of biphasic spindle cells and conventional squamous cell carcinoma components. Moreover, the surgical specimen also exhibited spindle tumor cells that frequently included neutrophils, around which intense staining for lysosomal-associated membrane protein 1 and cathepsin B was observed. This suggested that the cell-in-cell figures represent active neutrophil phagocytosis by tumor cells, and not emperipolesis. CONCLUSION: The presence of neutrophil phagocytosis may be a potent indicator of malignancy.

DOI： 10.1186/s13256-021-03066-z

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

<title>Abstract</title><sec>
<title>Objectives</title>
This study aimed to clarify the accuracy of intraoral ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) in preoperative image depth of invasion (DOI) measurement of T1/T2 tongue cancer through comparison with histopathological measurements.


</sec><sec>
<title>Methods</title>
Imaging of the primary lesions was performed at our hospital; the lesions were classified into T1 and T2 based on the 8th edition of the AJCC/UICC, and surgery performed. There was histopathological confirmation of lesions as squamous cell carcinoma in 48 patients with tongue cancer. T3 and T4 cases, cases in which preoperative chemotherapy and radiation therapy were performed, and cases where biopsy was performed before imaging were excluded. The radiological DOI in US, CT, and MRI and the histopathological DOI as base were comparatively investigated and statistical analyses were performed by Bland–Altman analysis and Spearman's rank correlation coefficient.


</sec><sec>
<title>Results</title>
Bland–Altman analysis showed that the US radiological DOI was overestimated by an average of 0.2 mm compared to the histopathological DOI, while CT and MRI radiological DOI were overestimated by an average of 2–3 mm. The comparison of CT and MRI revealed that the difference between the MRI and histopathological DOI, as well as the 95% limit of agreement, were smaller than those of the CT radiological DOI.


</sec><sec>
<title>Conclusions</title>
US is the most accurate preoperative diagnostic tool for T1 and T2 squamous cell carcinoma; CT and MRI tend to have an overestimation of about 2–3 mm and so caution is required.


</sec>

DOI： 10.1007/s11282-021-00533-7

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Other Link： https://link.springer.com/article/10.1007/s11282-021-00533-7/fulltext.html

Language：Japanese   Publisher：(NPO)日本歯科放射線学会  

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Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/osi2.1110

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1110

Language：Japanese   Publisher：(一社)日本口腔診断学会  

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Language：Japanese   Publisher：新潟歯学会  

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Language：Japanese   Publisher：(一社)日本口腔内科学会  

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Language：Japanese   Publisher：(一社)日本口腔腫瘍学会  

かかりつけ歯科医院での長期メインテナンス中、下顎埋伏智歯の歯冠部に関連して生じたと考えられる高齢者の原発性骨内癌を経験したので報告する。症例は74歳の男性、右側下唇の知覚異常と右側下顎臼歯部の咬合痛を主訴に当科紹介初診となった。右側下顎第二大臼歯は挺出し、動揺度2、頬側歯肉に軽度の腫脹を認めたが排膿はなかった。パノラマX線写真で右側下顎智歯は骨性に逆生埋伏しており、単純CTで埋伏智歯の歯冠部に連続した境界不明瞭で辺縁不整な35×25mm大の腫瘤性病変を認めた。生検にて扁平上皮癌(原発性骨内癌疑い)の診断を得て、顎下部郭清術、下顎骨区域切除術、金属プレートによる顎骨再建術を行った。一般的に原発性骨内癌は嚢胞様病変から悪性転化するとされるが、本症例は当科初診の8ヵ月前に紹介元で撮影されたパノラマX線写真では異常所見は観察されず、明白な嚢胞様変化を辿ることなく悪性転化し、急速に増大したと推察された。症状のない下顎埋伏智歯は経過観察されることが多いが、発育性嚢胞や歯周炎などのリスクが低いと判断される高齢者の下顎埋伏智歯においても、多様な変化の可能性も念頭に置いた経過観察が肝要である。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J02382&link_issn=&doc_id=20201221280014&doc_link_id=10.5843%2Fjsot.32.243&url=https%3A%2F%2Fdoi.org%2F10.5843%2Fjsot.32.243&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(一社)日本口腔診断学会  

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Lip closing functions have never been evaluated from the viewpoint of elastic properties. OBJECTIVES: The purpose of the present study was to investigate the behavior of the lower orbicularis oris muscle during a button-pull exercise to measure lip closing force and quantitatively evaluate its elastic properties using sonographic elastography. METHODS: Appropriate compression loads for elastography were randomly measured on one of three types of acoustic couplers on three examiners. Compression tests were performed on three types of acoustic couplers within the appropriate compression load. Using the acoustic coupler with the lowest elastic modulus, the strain ratio of the lower orbicularis oris muscle during lip closing was measured, and elastography was performed on six males under tension loads of 0-8 N. RESULTS: The intraclass correlation coefficient (1, 3) for the tension load of 0 N was 0.81. Elastography showed that the strain ratio values increased significantly (p < 0.05) as the tension load increased. CONCLUSIONS: Combining the data obtained from lip closing test devices and sonographic elastography enabled the muscle performance to be evaluated objectively and accurately.

DOI： 10.3233/BME-201101

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Language：Japanese   Publisher：(一社)日本口腔内科学会  

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Language：Japanese   Publisher：(一社)日本顎関節学会  

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Language：Japanese   Publisher：(一社)日本顎関節学会  

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: The present study was performed to investigate the mineral density distribution in enamel and dentin for both permanent and primary teeth and to establish the standard density per tooth type using micro-computed tomography (CT). METHODS: Fifty-seven extracted human teeth (37 permanent, 20 primary) were evaluated in the present study. The enamel and dentin mineral densities in the extracted teeth were measured using micro-CT. Cubic regression curves were used to determine the mineral density distribution in the enamel and dentin for each tooth type. RESULTS: The mean values, distributions, and regression equations of the mineral densities were obtained. The mean mineral density values for permanent enamel and dentin were significantly higher than those for their primary counterparts for each tooth type. CONCLUSIONS: In the present study, we demonstrated the distribution of mineral density in sound enamel and dentin and attempted to determine the standard mineral density for each tooth type using micro-CT. The mineral density distributions found in this study contribute to our understanding of the mechanical properties of enamel and dentin. A positive correlation suggests that the systemic bone mineral density could be predicted based on the analysis of exfoliated teeth, such as in patients with hypophosphatasia. The present results may be useful in establishing a numerical standard for the mechanism involved in root fracture and for early detection of root fracture risk.

DOI： 10.1007/s11282-018-0315-2

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Language：Japanese   Publisher：(一社)日本歯科心身医学会  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

OBJECTIVE: Myofascial pain in temporomandibular joint disorders (TMDs) is evoked by various factors, including edematous change. We investigated whether the pain pattern is related to edematous change by using T2 mapping generated by magnetic resonance imaging to detect water content in the tissue. STUDY DESIGN: One hundred and five patients diagnosed with TMDs, with or without unilateral masseter muscle pain, were divided into 6 groups according to their pain experience: pain on compression (23 cases), pain on movement (13 cases), spontaneous pain (4 cases), pain on compression and movement (14 cases), pain on compression and spontaneous pain (2 cases), and no pain (49 cases). Differences in the mean T2 values of the masseter muscle between the group with pain on only one side (5 unilateral pain groups) or pain-free on both the right and left sides (pain-free group) were compared with paired t tests. Significant differences were assumed at P < .05. RESULTS: Significant differences in mean T2 values were found between the painful and pain-free sides in the group with pain on compression. CONCLUSIONS: The findings of edematous change in the masseter muscle of patients with pain on compression may affect treatment planning and lead to investigation of treatment options for myofascial pain in TMDs.

DOI： 10.1016/j.oooo.2018.06.003

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Language：Japanese   Publisher：医歯薬出版(株)  

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Language：Japanese   Publisher：(一社)日本顎関節学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：English   Publishing type：Research paper (scientific journal)  

© 2018, Japanese Society for Oral and Maxillofacial Radiology and Springer Nature Singapore Pte Ltd. Dental cone-beam computed tomography (CBCT) received regulatory approval in Japan in 2000 and has been widely used since being approved for coverage by the National Health Insurance system in 2012. This imaging technique allows dental practitioners to observe and diagnose lesions in the dental hard tissue in three dimensions (3D). When performing routine radiography, the examination must be justified, and optimal protection should be provided according to the ALARA (as low as reasonably achievable) principles laid down by the International Commission on Radiological Protection. Dental CBCT should be performed in such a way that the radiation exposure is minimized and the benefits to the patient are maximized. There is a growing demand for widespread access to cutting-edge health care through Japan’s universal health insurance system. However, at the same time, people want our limited human, material, and financial resources to be used efficiently while providing safe health care at the least possible cost to society. Japan’s aging population is expected to reach a peak in 2025, when most of the baby boomer generation will be aged 75 years or older. Comprehensive health care networks are needed to overcome these challenges. Against this background, we hope that this text will contribute to the nation’s oral health by encouraging efficient use of dental CBCT.

DOI： 10.1007/s11282-018-0314-3

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Language：Japanese   Publisher：(NPO)日本歯科放射線学会  

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Language：Japanese   Publisher：(NPO)日本歯科放射線学会  

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Language：Japanese   Publisher：(NPO)日本歯科放射線学会  

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Language：Japanese   Publisher：新潟歯学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

The aim of this study was to estimate the clinical significance of using intraoral strain elastography to establish an early diagnosis of tongue carcinoma.
A total of 17 patients (11 men, 6 women; median age 67 years; age range 38-85 years) with a tumorous lesion of the tongue suggesting that early stage tongue carcinoma were enrolled in the study. Intraoral strain elastography was performed with a small hockey stick-shaped intraoperative probe and acoustic coupling polymer gel. The elasticity of the lesions was classified into four grades, with a score of 1 indicating a very soft tissue and a score of 4 indicating a very hard tissue. The patients were divided into two groups based on the histopathologically verified malignancy: carcinoma group (n = 15) and non-malignancy group (n = 2).
All patients underwent surgical resection and histopathological examination of the surgical specimen. The pathology in the carcinoma group included 12 cases of squamous cell carcinoma and three cases of carcinoma in situ. The pathology in the non-malignancy group included one case of viral stomatitis and one case of pyogenic granuloma. The elasticity score was limited to 3 or 4 in the carcinoma group and 1 or 2 in the non-malignancy group. There was no significant difference in the elasticity scores between squamous cell carcinoma and carcinoma in situ.
Although limited by the small number of subjects, the present results suggest that intraoral strain elastography could be an alternative noninvasive method for diagnosing tongue carcinoma.

DOI： 10.1007/s11282-016-0269-1

Web of Science

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Language：Japanese   Publisher：(NPO)日本歯科放射線学会  

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Language：Japanese   Publisher：(NPO)日本歯科放射線学会  

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Language：English  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

Most cases of hypophosphatasia (HPP) exhibit early loss of primary teeth. Results of microcomputed tomography (micro-CT) analysis of teeth with HPP have rarely been reported. The purpose of the present study was to describe the mineral density distribution and mapping of exfoliated teeth from an HPP patient using micro-CT. Four exfoliated teeth were obtained from a patient with HPP. Enamel and dentin mineral densities of exfoliated teeth were measured on micro-CT. The mean values of enamel and dentin mineral densities in mandibular primary central incisors with HPP were 1.61 and 0.98 g/cm3, respectively. The corresponding values in the mandibular primary lateral incisors were 1.60 and 0.98 g/cm3, respectively. Enamel hypoplasia was seen in the remaining teeth, both maxillary and mandibular primary canines and first and second molars. Micro-CT enables nondestructive, noninvasive evaluation and is useful for studying human hard tissues obtained from patients.

DOI： 10.1155/2016/4898456

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Language：Japanese   Publisher：新潟歯学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Objectives: Masticatory muscle pain is one of the typical symptoms of temporomandibular joint disorders (TMD). T2 mapping (distribution of T2 values) is a notable MRI technique for evaluating water contents in tissues. We investigated the clinical significance of T2 mapping for the evaluation of masticator muscle conditions by comparing the difference in the T2 values between the painful and pain-free sides of the masseter muscle in patients with TMD. Methods: Seventy-three patients clinically diagnosed with TMD were enrolled in this study. We divided the patients into two groups: a unilateral pain group (patients with unilateral masseter muscle pain) and a painless group (patients without muscle pain). There were 29 patients in the unilateral pain group and 44 patients in the painless group. We compared the difference in the mean T2 values between the painful and pain-free sides of the masseter muscle in the unilateral pain group and between the right and left sides in the painless group. Results: The mean T2 values of the masseter muscle on the painful side were significantly higher than those on the pain-free side in the unilateral muscle pain group (p &lt
0.01). In the painless group, there was no significant difference in the mean T2 values between the right and left sides. Conclusions: It is suggested that T2 mapping is a promising method for evaluating masseter muscle pain caused by edematous change related to TMD through monitoring of the T2 values. © 2012 Japanese Society for Oral and Maxillofacial Radiology and Springer Japan.

DOI： 10.1007/s11282-012-0108-y

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Language：Japanese   Publisher：(一社)日本顎関節学会  

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Language：Japanese   Publisher：新潟歯学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2008&ichushi_jid=J00999&link_issn=&doc_id=20080811360013&doc_link_id=%2Fdj2ngtdt%2F2008%2F003801%2F018%2F0047-0047%26dl%3D2&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdj2ngtdt%2F2008%2F003801%2F018%2F0047-0047%26dl%3D2&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_5.gif

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Language：English   Publishing type：Research paper (scientific journal)  

The EUB-8500 with the newly-developed “real-time tissue elastography” technology enables the tissue elasticity to be displayed. Real-time tissue elastography may thus be useful for characterizing pathological tissue in cervical lymph node metastases in oral cancer. Therefore, we studied its clinical usefulness in diagnosing cervical lymph node metastases in oral cancer using an ultrasound diagnostic system equipped with the real-time tissue elastographic function. Twenty-six lymph nodes in 15 patients with oral cancer were enrolled in this study. Based on the Tsukuba Elastography Score, we classified real-time tissue elastographic images of lymph nodes in five patterns. The patterns of images were compared with the histopathological diagnosis obtained by surgery. Furthermore, we considered lymph nodes as non-metastatic when no metastatic findings were observed within a follow-up period of one year or more. Metastatic lymph nodes showed pattern 3, 4 or 5. Non-metastatic lymph nodes showed pattern 1 or 2. The differences of tissue elasticity between metastatic lymph nodes and non-metastatic lymph nodes were clearly identified. If the patterns above category 3 were assumed as metastases, the precision of diagnosis was as follows: sensitivity of 92%, specificity of 86%, accuracy of 88%, PPV (positive predictive value) of 85% and NPV (negative predictive value) of 92%. Additionally, metastatic lymph nodes with a minimum axial diameter of 0.5 cm could be precisely detected using elastography. Real-time tissue elastography is a promising method which allows characterization and differentiation of benign and malignant lymph nodes with a high sensitivity, specificity and accuracy, offering complementary information to conventional ultrasonographic imaging. © 2008, Japan Society for Head and Neck Cancer. All rights reserved.

DOI： 10.5981/jjhnc.34.518

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Language：Japanese   Publisher：(一社)日本顎関節学会  

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Language：Japanese   Publisher：新潟医学会  

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Other Link： http://search.jamas.or.jp/link/ui/2013376196

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Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2008317038

Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2008317042

Language：Japanese   Publisher：新潟大学  

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Other Link： http://hdl.handle.net/10191/19560

Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2008156700

Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Poster presentation  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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