2022/11/29 更新

写真a

アジオカ ヨウイチ
味岡 洋一
AJIOKA Yoichi
所属
教育研究院 医歯学系 医学系列 教授
医歯学総合研究科 分子細胞医学専攻 細胞機能 教授
職名
教授
外部リンク

学位

  • 医学博士 ( 1987年1月   新潟大学 )

研究キーワード

  • 人体病理

  • Human pathology

経歴(researchmap)

経歴

  • 新潟大学   医歯学総合研究科 分子細胞医学専攻 細胞機能   教授

    2016年4月 - 現在

  • 新潟大学   医歯学総合研究科 分子細胞医学専攻   教授

    2004年4月 - 2016年3月

  • 新潟大学   医学部 医学科   教授

    2004年4月 - 2016年3月

  • 新潟大学   医学部   講師

    1993年11月 - 1995年7月

  • 新潟大学   医学部   助手

    1990年2月 - 1993年1月

学歴

  • 新潟大学   Graduate School, Division of Medicine

    - 1988年

      詳細を見る

  • 新潟大学   医学研究科   医学

    - 1988年

      詳細を見る

    国名: 日本国

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  • 新潟大学   Faculty of Medicine

    - 1984年

      詳細を見る

  • 新潟大学   医学部   医学

    - 1984年

      詳細を見る

    国名: 日本国

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所属学協会

▶ 全件表示

委員歴

  • 日本胃癌学会   幹事  

    1998年 - 1999年   

      詳細を見る

    団体区分:学協会

    日本胃癌学会

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  • 日本病理学会   学術評議員  

      詳細を見る

    団体区分:学協会

    日本病理学会

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  • 日本食道癌学会   評議員  

      詳細を見る

    団体区分:学協会

    日本食道癌学会

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留学歴

  • オークランド大学 (University of Auckland)、ニュージーランド   研究員

    1995年7月 - 1997年1月

取得資格

  • 医師

  • 日本病理学会専門医

  • 日本病理学会指導医

 

書籍等出版物

  • 大腸疾患ケーススタデイ-診断の基本から最先端まで

    2002年 

     詳細を見る

  • 特殊な胃癌の診断と経過

    消化器癌の発生と自然史  2000年 

     詳細を見る

  • 大腸の非腫瘍性ポリープ・ポリポーシス

    大腸・肛門外科  1999年 

     詳細を見る

  • sm癌診断における病理医の役割-病理診断の不一致はなぜ生じるか

    大腸sm癌-内視鏡診断と治療  1999年 

     詳細を見る

  • 大腸癌の病理診断-m癌の病理学的診断

    大腸の臨床分子病理学  1998年 

     詳細を見る

  • 内視鏡材料の取り扱い

    大腸検査法マニュアル  1994年 

     詳細を見る

  • Histogenesis of gastrointestinal carcinomas in Peutz-Jeghers polyp

    Hereditary colorectal cancer  1990年 

     詳細を見る

  • Pathology of Gastrointestinal lesions in familial adenomatosis coli

    Hereditary colorectal cancer  1990年 

     詳細を見る

  • Histogenesis of gastrointestinal carcinomas in Peutz-Jeghers polyp

    Hereditary colorectal cancer  1990年 

     詳細を見る

  • Pathology of Gastrointestinal lesions in familial adenomatosis coli

    Hereditary colorectal cancer  1990年 

     詳細を見る

▶ 全件表示

MISC

  • Loss of heterozygosity in the clonal evolution of flat colorectal neoplasms

    H Fujii, Y Ajioka, S Kazami, T Takagaki, XG Zhu, S Hirose, H Watanabe, T Shirai

    JOURNAL OF PATHOLOGY   197 ( 3 )   298 - 306   2002年7月

     詳細を見る

    記述言語:英語   出版者・発行元:JOHN WILEY & SONS LTD  

    In contrast to invasive colorectal carcinomas that develop in typical exophytic adenoma-carcinoma sequences, some invasive cancers may evolve from flat mucosal dysplastic lesions. Despite their relatively small size, these flat colorectal lesions are often associated with high-grade dysplasia and may show an aggressive clinical course. To delineate the genetic pathways in the clonal evolution of these tumors, multiple foci were microdissected from 13 cases and the allelic deletions of 15 chromosomal arms were analysed. Loss of heterozygosity (LOH) was detected most frequently on 17p (77%), followed by 18q (69%), and 5q (54%). In five cases with concomitant low-grade adenomas, only one case showed LOH in low-grade adenoma foci. In high-grade dysplasia with/without submucosal invasion. early and homogeneous LOH of one to several chromosomal arms was detected. Overall. homogeneous and thus early LOH Acre most frequently detected on 17p (seven of 10 cases with 17p LOH). followed by 3p (two of three cases with 3p LOH), and 5q (four of seven cases with 5q LOH). In addition to homogeneous LOH, the LOH patterns observed in different portions of dysplasias and invasive cancers in individual cases identified several different genetic patterns of tumour progression, either with linear or branching (divergent) trees. Positive immunostaining for p53 was detected in 10 of the 13 cases; of these, five cases were concomitant with 17p LOH in all of the microdissected foci, four cases were concomitant with 17p LOH in a majority of foci and, one case showed retention of 17p. Except for the flat configuration and early 17p LOH. genetic heterogeneity in the flat high-grade dysplastic foci was found to be similar to genetic chaos in the late dysplastic and preinvasive stages of exophytic adenoma. These findings suggest a potentially aggressive course for these neoplasms. Copyright (C) 2002 John Wiley Sons. Ltd.

    DOI: 10.1002/path.1122

    Web of Science

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  • Loss of heterozygosity in the clonal evolution of flat colorectal neoplasms

    H Fujii, Y Ajioka, S Kazami, T Takagaki, XG Zhu, S Hirose, H Watanabe, T Shirai

    JOURNAL OF PATHOLOGY   197 ( 3 )   298 - 306   2002年7月

     詳細を見る

    記述言語:英語   出版者・発行元:JOHN WILEY & SONS LTD  

    In contrast to invasive colorectal carcinomas that develop in typical exophytic adenoma-carcinoma sequences, some invasive cancers may evolve from flat mucosal dysplastic lesions. Despite their relatively small size, these flat colorectal lesions are often associated with high-grade dysplasia and may show an aggressive clinical course. To delineate the genetic pathways in the clonal evolution of these tumors, multiple foci were microdissected from 13 cases and the allelic deletions of 15 chromosomal arms were analysed. Loss of heterozygosity (LOH) was detected most frequently on 17p (77%), followed by 18q (69%), and 5q (54%). In five cases with concomitant low-grade adenomas, only one case showed LOH in low-grade adenoma foci. In high-grade dysplasia with/without submucosal invasion. early and homogeneous LOH of one to several chromosomal arms was detected. Overall. homogeneous and thus early LOH Acre most frequently detected on 17p (seven of 10 cases with 17p LOH). followed by 3p (two of three cases with 3p LOH), and 5q (four of seven cases with 5q LOH). In addition to homogeneous LOH, the LOH patterns observed in different portions of dysplasias and invasive cancers in individual cases identified several different genetic patterns of tumour progression, either with linear or branching (divergent) trees. Positive immunostaining for p53 was detected in 10 of the 13 cases; of these, five cases were concomitant with 17p LOH in all of the microdissected foci, four cases were concomitant with 17p LOH in a majority of foci and, one case showed retention of 17p. Except for the flat configuration and early 17p LOH. genetic heterogeneity in the flat high-grade dysplastic foci was found to be similar to genetic chaos in the late dysplastic and preinvasive stages of exophytic adenoma. These findings suggest a potentially aggressive course for these neoplasms. Copyright (C) 2002 John Wiley Sons. Ltd.

    DOI: 10.1002/path.1122

    Web of Science

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  • Comparison of cyclo-oxygenase 2 expression in colorectal serrated adenomas to expression in tubular adenomas and hyperplastic polyps

    M Takeuchi, M Kobayashi, Y Ajioka, T Honma, Y Suzuki, M Azumaya, R Narisawa, S Hayashi, H Asakura

    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE   17 ( 3 )   144 - 149   2002年5月

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    記述言語:英語   出版者・発行元:SPRINGER-VERLAG  

    Background and aims: Serrated adenoma (SA) is a newly defined category of colorectal neoplasia that contains features of both adenoma and hyperplastic polyp, and has two patterns, hyperplastic and cerebriform patterns. Since cyclooxygenase 2 (COX-2) has been found upregulated in colorectal cancers and adenomas, we examined whether either the hyperplastic or cerebriform pattern of SA has the potential for tumor progression and should be a target for clinical treatment. Patients and methods: An immunohistochemical scoring system was used to compare COX-2 expression in colorectal SAs (n=79), tubular adenomas (n=66), and hyperplastic polyps (n=21). Results: COX-2 scores were significantly higher in SA of the cerebriform pattern (n=44) than in SA of the hyperplastic pattern (n=35). There was no difference in COX-2 scores between SA of the cerebriform pattern and tubular adenoma. In SA accompanied by hyperplastic polyp (n=26) the hyperplastic components expressed little COX-2, the same as traditional hyperplastic polyps. COX-2 expression in the SA component was similar to that in pure SA. Conclusion: SA of the cerebriform pattern should be treated similarly as traditional tubular adenomas. COX-2 induction may additionally be involved in progression from hyperplastic polyp to SA.

    DOI: 10.1007/s00384-001-0372-5

    Web of Science

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  • Comparison of cyclo-oxygenase 2 expression in colorectal serrated adenomas to expression in tubular adenomas and hyperplastic polyps

    M Takeuchi, M Kobayashi, Y Ajioka, T Honma, Y Suzuki, M Azumaya, R Narisawa, S Hayashi, H Asakura

    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE   17 ( 3 )   144 - 149   2002年5月

     詳細を見る

    記述言語:英語   出版者・発行元:SPRINGER-VERLAG  

    Background and aims: Serrated adenoma (SA) is a newly defined category of colorectal neoplasia that contains features of both adenoma and hyperplastic polyp, and has two patterns, hyperplastic and cerebriform patterns. Since cyclooxygenase 2 (COX-2) has been found upregulated in colorectal cancers and adenomas, we examined whether either the hyperplastic or cerebriform pattern of SA has the potential for tumor progression and should be a target for clinical treatment. Patients and methods: An immunohistochemical scoring system was used to compare COX-2 expression in colorectal SAs (n=79), tubular adenomas (n=66), and hyperplastic polyps (n=21). Results: COX-2 scores were significantly higher in SA of the cerebriform pattern (n=44) than in SA of the hyperplastic pattern (n=35). There was no difference in COX-2 scores between SA of the cerebriform pattern and tubular adenoma. In SA accompanied by hyperplastic polyp (n=26) the hyperplastic components expressed little COX-2, the same as traditional hyperplastic polyps. COX-2 expression in the SA component was similar to that in pure SA. Conclusion: SA of the cerebriform pattern should be treated similarly as traditional tubular adenomas. COX-2 induction may additionally be involved in progression from hyperplastic polyp to SA.

    DOI: 10.1007/s00384-001-0372-5

    Web of Science

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  • Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of colorectal carcinoma liver metastases

    N Yokoyama, Y Shirai, Y Ajioka, S Nakakura, T Suda, K Hatakeyama

    CANCER   94 ( 6 )   1642 - 1647   2002年3月

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    記述言語:英語   出版者・発行元:JOHN WILEY & SONS INC  

    BACKGROUND. Hepatic metastases from colorectal carcinoma frequently recur after resection and hepatic micrometastases most likely are important in the development of such recurrences. The objectives of the current study were to assess the feasibility of the immunohistochemical detection of hepatic micrometastases from colorectal carcinoma and to determine their clinical significance.
    METHODS. Fifty-three patients underwent curative hepatic resection for colorectal carcinoma metastases. Multiple tissue sections were cut from the advancing margin of the largest hepatic metastasis in each patient and were stained with an antibody against cytokeratin-20 to detect hepatic micrometastases, which were defined as discrete microscopic cancerous lesions surrounding the dominant metastasis.
    RESULTS. Normal hepatocytes and intrahepatic bile duct epithelia stained negative for cytokeratin-20 in all patients, whereas the largest hepatic tumors stained positive in 46 patients (86.8%). Among the 46 patients with hepatic tumors that were positive for cytokeratin-20, hepatic micrometastases were found immunohistochemically in 32 patients (69.6%). The presence of hepatic micrometastases was associated with a larger number of macroscopic hepatic metastases (P = 0.047) and patients with hepatic micrometastases were found to demonstrate a higher probability of intrahepatic recurrence (P = 0.003) compared with those patients without hepatic micrometastases. In addition, patients with hepatic micrometastases demonstrated a worse survival (10-year survival rate of 21.9%) compared with those patients without hepatic micrometastases (10-year survival rate of 64.3%) (P = 0.017).
    CONCLUSIONS. Immunohistochemical detection of hepatic micrometastases is feasible in patients with colorectal carcinoma liver metastases. Hepatic micrometastasis indicates widespread hepatic involvement and thus predicts an increased risk of intrahepatic recurrence after hepatic resection and a poorer patient prognosis. (C) 2002 American Cancer Society

    DOI: 10.1002/cncr.10422

    Web of Science

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  • Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of colorectal carcinoma liver metastases

    N Yokoyama, Y Shirai, Y Ajioka, S Nakakura, T Suda, K Hatakeyama

    CANCER   94 ( 6 )   1642 - 1647   2002年3月

     詳細を見る

    記述言語:英語   出版者・発行元:JOHN WILEY & SONS INC  

    BACKGROUND. Hepatic metastases from colorectal carcinoma frequently recur after resection and hepatic micrometastases most likely are important in the development of such recurrences. The objectives of the current study were to assess the feasibility of the immunohistochemical detection of hepatic micrometastases from colorectal carcinoma and to determine their clinical significance.
    METHODS. Fifty-three patients underwent curative hepatic resection for colorectal carcinoma metastases. Multiple tissue sections were cut from the advancing margin of the largest hepatic metastasis in each patient and were stained with an antibody against cytokeratin-20 to detect hepatic micrometastases, which were defined as discrete microscopic cancerous lesions surrounding the dominant metastasis.
    RESULTS. Normal hepatocytes and intrahepatic bile duct epithelia stained negative for cytokeratin-20 in all patients, whereas the largest hepatic tumors stained positive in 46 patients (86.8%). Among the 46 patients with hepatic tumors that were positive for cytokeratin-20, hepatic micrometastases were found immunohistochemically in 32 patients (69.6%). The presence of hepatic micrometastases was associated with a larger number of macroscopic hepatic metastases (P = 0.047) and patients with hepatic micrometastases were found to demonstrate a higher probability of intrahepatic recurrence (P = 0.003) compared with those patients without hepatic micrometastases. In addition, patients with hepatic micrometastases demonstrated a worse survival (10-year survival rate of 21.9%) compared with those patients without hepatic micrometastases (10-year survival rate of 64.3%) (P = 0.017).
    CONCLUSIONS. Immunohistochemical detection of hepatic micrometastases is feasible in patients with colorectal carcinoma liver metastases. Hepatic micrometastasis indicates widespread hepatic involvement and thus predicts an increased risk of intrahepatic recurrence after hepatic resection and a poorer patient prognosis. (C) 2002 American Cancer Society

    DOI: 10.1002/cncr.10422

    Web of Science

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  • Bcl-2 expression and frequency of apoptosis correlate with morphogenesis of colorectal neoplasia

    J Clinical Pathol   55, 212-217   2002年

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  • Size-dependent expression of cyclooxygenase-2 in sporadic colorectal adneomas relative to adenomas in patients with familial adenomatous polyposis

    Pathology Int   52, 272-276   2002年

  • Size-dependent expression of cyclooxygenase-2 in sporadic colorectal adneomas relative to adenomas in patients with familial adenomatous polyposis

    Pathology Int   52, 272-276   2002年

  • Sensitivity of biopsy site in evaluating regerssion of gastric atrophy after Helicobacter pylori eradication treatment

    Aliment Pharmacol Ther   16, 187-190   2002年

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  • Not infrequent K-ras mutations in depressed-type early colorectal carcinomas larger than 10mm

    Jpn J Cancer Res   93, 178-183   2002年

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  • Pathological appraisal of lines of resection for bile duct carcinoma

    Brit J Surg   89, 1260-1267   2002年

  • Pathological appraisal of lines of resection for bile duct carcinoma

    Brit J Surg   89, 1260-1267   2002年

  • (総説)リンパ節微小転移(lymph node micrometastasis)と脈管侵襲

    消化器病セミナー (大腸sm癌-今日の診断と治療)   86, 71-80   2002年

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  • Sensitivity of biopsy site in evaluating regerssion of gastric atrophy after Helicobacter pylori eradication treatment

    Aliment Pharmacol Ther   16, 187-190   2002年

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  • Not infrequent K-ras mutations in depressed-type early colorectal carcinomas larger than 10mm

    Jpn J Cancer Res   93, 178-183   2002年

     詳細を見る

  • 下部直腸にびまん性狭窄を来した前立腺癌の1例

    胃と腸   37, 211-219   2002年

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  • Bcl-2 expression and frequency of apoptosis correlate with morphogenesis of colorectal neoplasia

    J Clinical Pathol   55, 212-217   2002年

     詳細を見る

  • cap polyposisと隆起型MPSとの病理組織学的差異

    胃と腸   37, 661-670   2002年

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  • colitic cancer / dysplasiaの病理組織学的特徴

    胃と腸   37, 956-970   2002年

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  • Heterogeneity of p53 mutational status in the superficial spreading type of early gastric carcinoma

    Hiroshi Iwamatsu, Ken Nishikura, Hidenobu Watanabe, Yoichi Ajioka, Hideki Hashidate, Hiroshi Kashimura, Hitoshi Asakura

    Gastric Cancer   4 ( 1 )   20 - 26   2001年

     詳細を見る

    記述言語:英語  

    Background. The superficial spreading type of gastric carcinoma may originate from either a single cellular clone or from several different clones
    this issue remains controversial. Indeed, the p53 gene has been shown to play an important role in gastric carcinogenesis, but there have been only a few reports on the heterogeneity of gastric carcinoma with respect to the p53 gene. Methods. We analyzed seven cases of the superfcial spreading type of gastric submucosal carcinomas (80 lesions
    10 to 17 per case) which showed different histological types and/or different p53 protein staining patterns. Direct sequences of polymerase chain reaction products were used for the analysis. Results. p53 Gene heterogeneity in mucosal carcinoma lesions was detected in three cases. However, in all of the cases, the p53 mutational pattern was identical to that found in the submucosal carcinoma lesions. In the heterogeneous cases, the mutation in the submucosal carcinoma was one of the mutation patterns found among the mucosal carcinoma lesions. More precisely, the mutational pattern of both submucosal carcinoma lesions and the mucosal lesions located just above them, was identical. Conclusion. These data suggest that, with regard to the p53 gene, in some superficial spreading types of gastric carcinomas, there are various subclones in the mucosal carcinoma
    one of these subclones becomes predominant through clonal selection, and, thus, invades the submucosa.

    DOI: 10.1007/s101200100012

    Scopus

    PubMed

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  • Heterogeneity of p53 mutational status in intramucosal carcinoma of the colorectum

    Jpn J Cancer Res   92, 161-166   2001年

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  • 微小リンパ節転移の免疫組織学的検出法

    Surgery Frontier   8, 8-12   2001年

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  • Mutations of p53 in morphologically non-neoplastic mucosa of long-standing ulcerative colitis

    Jpn J Cancer Res   92, 119-126   2001年

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  • Sweet病を合併した潰瘍性大腸炎の1例

    日本消化器病学会雑誌   98, 32-36   2001年

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  • 食道胃接合部癌の病理学的特徴-組織発生の面からBarrett食道癌と比較して

    胃と腸   36, 634-650   2001年

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  • 特殊な大腸癌(3) Colitic cancer

    早期大腸癌   5, 269-274   2001年

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  • 大腸sm癌のリンパ節微小転移(lymph node micrometastasis)と脈管侵襲

    早期大腸癌   5, 471-477   2001年

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  • 大腸内視鏡検査で発見された終末回腸の微小癌・腺腫の1例

    胃と腸   36, 895-898   2001年

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  • 10mm以下の大腸sm massive癌の病理学的特徴

    胃と腸   36, 1353-1362   2001年

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  • 大腸sm癌の病理組織と実体顕微鏡観察下pit patternとの対比

    早期大腸癌   5, 49-561   2001年

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  • Heterogeneity of p53 mutational status in intramucosal carcinoma of the colorectum

    Jpn J Cancer Res   92, 161-166   2001年

     詳細を見る

  • Heterogeneity of p53 mutational status in the superficial spreading type of early gastric carcinoma

    Hiroshi Iwamatsu, Ken Nishikura, Hidenobu Watanabe, Yoichi Ajioka, Hideki Hashidate, Hiroshi Kashimura, Hitoshi Asakura

    Gastric Cancer   4 ( 1 )   20 - 26   2001年

     詳細を見る

    記述言語:英語  

    Background. The superficial spreading type of gastric carcinoma may originate from either a single cellular clone or from several different clones
    this issue remains controversial. Indeed, the p53 gene has been shown to play an important role in gastric carcinogenesis, but there have been only a few reports on the heterogeneity of gastric carcinoma with respect to the p53 gene. Methods. We analyzed seven cases of the superfcial spreading type of gastric submucosal carcinomas (80 lesions
    10 to 17 per case) which showed different histological types and/or different p53 protein staining patterns. Direct sequences of polymerase chain reaction products were used for the analysis. Results. p53 Gene heterogeneity in mucosal carcinoma lesions was detected in three cases. However, in all of the cases, the p53 mutational pattern was identical to that found in the submucosal carcinoma lesions. In the heterogeneous cases, the mutation in the submucosal carcinoma was one of the mutation patterns found among the mucosal carcinoma lesions. More precisely, the mutational pattern of both submucosal carcinoma lesions and the mucosal lesions located just above them, was identical. Conclusion. These data suggest that, with regard to the p53 gene, in some superficial spreading types of gastric carcinomas, there are various subclones in the mucosal carcinoma
    one of these subclones becomes predominant through clonal selection, and, thus, invades the submucosa.

    DOI: 10.1007/s101200100012

    Scopus

    PubMed

    researchmap

  • Mutations of p53 in morphologically non-neoplastic mucosa of long-standing ulcerative colitis

    Jpn J Cancer Res   92, 119-126   2001年

     詳細を見る

  • 潰瘍性大腸炎に発生した大腸癌 ulcerative colitis associated colorectal cancer (colitic cancer)

    病理と臨床   18, 1250-1251   2000年

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  • Early colorectal cancer with special reference to the superficial nonpolypoid type from a histopathologic point of view

    World J Surg   24, 1075-1080   2000年

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  • 大腸serrated adenomaの臨床病理学的検討

    日本消化器病学会雑誌   42, 247-257   2000年

  • 消化管病理基礎講座(3) 大腸癌の肉眼像と組織所見の対比

    胃と腸   35, 1300-1306   2000年

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  • Helicobacter pylori胃炎と胃カルチノイドの関連性

    胃と腸   35, 1417-1421   2000年

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  • 表面陥凹型から表面隆起型へ形態が変化した大腸微小腺腫の1例

    日本内視鏡学会誌   42, 1090-1095   2000年

  • 胃カルチノイドの分類の変遷

    胃と腸   35, 1349-1354   2000年

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  • 大きな(2cm以上)ポリープの取り扱い-臨床病理学的特徴

    早期大腸癌   4, 503-510   2000年

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  • Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype

    Am J Pathol   157, 717-722   2000年

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  • Significance of immunohistochemically demonstrated micrometastases to lymphnodes in esophageal cancer with histologically negative nodes

    Surgery   127, 40-46   2000年

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  • Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways

    J Pathol   191, 257-263   2000年

  • Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies

    Pathology International   50, 332-335   2000年

  • Stromal sialyl Lea expression is correlated with vascular invasion of human gallbladder adenocarcinoma

    J Oncol   17, 55-60   2000年

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  • Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways

    J Pathol   191, 257-263   2000年

  • Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies

    Pathology International   50, 332-335   2000年

  • When can complete regression of low-grade gastric lymphoma of mucosa-associated lymphoid tissue be predicted after Helicobacter pylori eradication ?

    Histopathology   37, 131-140   2000年

  • Nuclear translocation of beta-catenin in colorectal cancer

    Brit J Cancer   82, 1689-1693   2000年

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  • Nuclear translocation of beta-catenin in colorectal cancer

    Brit J Cancer   82, 1689-1693   2000年

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  • Different amounts of K-ras mutatn epithelial cells in pancreatic carcinoma and mass-forming pancreatitis

    Pancreas   21, 77-85   2000年

  • Different amounts of K-ras mutatn epithelial cells in pancreatic carcinoma and mass-forming pancreatitis

    Pancreas   21, 77-85   2000年

  • When can complete regression of low-grade gastric lymphoma of mucosa-associated lymphoid tissue be predicted after Helicobacter pylori eradication?

    Histopathology   37, 131-140   2000年

  • Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype

    Am J Pathol   157, 717-722   2000年

     詳細を見る

  • sm癌診断における粘膜筋板の判定方法(3)癌のsm浸潤に伴う変膜筋板の変化と大腸sm癌の浸潤度判定

    早期大腸癌   4, 145-154   2000年

     詳細を見る

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    World J Surg   24, 1075-1080   2000年

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    Human Pathology   30, 826-832   1999年

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    Annals of Oncol   10, 136-139   1999年

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    Human Pathology   30, 826-832   1999年

  • Immunohistochemical staining patterns of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenoma of the colorectum

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    Cancer   86, 596-607   1999年

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    Jpn J Cancer Res   40, 841-848   1999年

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  • Histological and genetic changes in malignant transformation of gallbaldder adenoma

    Annals of Oncol   10, 136-139   1999年

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    Gastric cancer   2, 33-39   1999年

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    J Pathol   189, 201-206   1999年

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    J Clinical Pathol   52, 5-9   1999年

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    消化器外科   22, 101-104   1999年

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  • DNA microsaterllite instability in hyperplastic polyps, serrated adenomas, and mixed polyps : a mild mutator pathway for colorectal cancer ?

    J Clinical Pathol   52, 5-9   1999年

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  • The common 18-base pair deletion at codons 418-423 of the E-cadherin gene in differentiated-type adenocarcinomas and intramucosal precancerous lesions of the stomach with the features of gastric foveolar epithelium

    J Pathol   189, 201-206   1999年

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    胃と腸   34, 16   1999年

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    胆と膵   20, 277-284   1999年

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    胃と腸   34, 123-132   1999年

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    臨床外科   54, 645-648   1999年

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  • Risk factors for nodal micrometastasis of submucosal gastric carcinoma: assessment of indications for endoscopic treatment

    Gastric cancer   2, 33-39   1999年

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  • Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater

    Cancer   86, 596-607   1999年

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  • Multiple K-ras mutations in hyperplasia and carcinoma in cases of human pancreatic carcinoma

    Jpn J Cancer Res   40, 841-848   1999年

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  • 胃型分化型腺癌の判定基準と病理学的特徴

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    BRAIN and NERVE   50, 186-189   1998年

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  • Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer : a comparison with genetic analysis of K-ras

    Histopathology   32, 199-208   1998年

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    Jpn J Cancer Res   89, 40-46   1998年

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    Jpn J Cancer Res   89, 405-410   1998年

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  • Infrequent K-ras codon-12 mutation in serrated adenomas of human colorectum

    Gut   42, 680-684   1998年

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  • Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer : a comparison with genetic analysis of K-ras

    Histopathology   32, 199-208   1998年

  • Mutation of p53 in gallbladder carcinomas in high-incidence areas of Japan and Chile

    Cancer Epidemiology, Biomarkers & Prevention   7, 297-301   1998年

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  • Primary pancreatic ductal microcarcinomas arising from interlobular duct and ductules

    Acta Medica et Biologica   46, 113-120   1998年

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    J Gastroenterology   33, 662-669   1998年

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    Cancer   82, 651-660   1998年

  • Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation

    Cancer   82, 651-660   1998年

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    J Gastroenterology   33, 662-669   1998年

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  • 大腸にMALT組織、MALTリンパ腫は存在するか?

    胃と腸   33, 483-484   1998年

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    Jpn J Cancer Res   89, 405-410   1998年

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    Cancer Epidemiology, Biomarkers & Prevention   7, 297-301   1998年

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    胃と腸   33, 373-382   1998年

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  • Infrequent K-ras codon-12 mutation in serrated adenomas of human colorectum

    Gut   42, 680-684   1998年

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  • 大腸のserrated adenoma (私の診断基準)

    胃と腸   33, 835-841   1998年

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    からだの科学   199, 30-33   1998年

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    Acta Medica et Biologica   46, 113-120   1998年

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    外科   60, 1539-1542   1998年

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    日本外科学会雑誌   99, 687-695   1998年

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    消化器内視鏡   10, 1488-1493   1998年

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  • Alteration of p53 clonality accompanying colorectal cancer progression

    Jpn J Cancer Res   89, 40-46   1998年

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    早期大腸癌   2, 175-181   1998年

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  • 形態計測とp53蛋白、Ki-67免疫染色からみた大腸腺腫と腺癌

    病理と臨床   16, 37-43   1998年

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  • p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: Correlation with histologic factors

    Pathology International   47, 531-539   1997年

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  • Correlation of p53 protein expression with gene mutation in gall-bladder carcinoma

    Pathology International   47, 525-530   1997年

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    J Clinical Pathol   50, 417-421   1997年

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    J Gastroenterology   32, 635-642   1997年

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  • Correlative histochemical study providing evidence for the dual nature of human colorectal cancer mucin

    Histochemical Journal   29, 143-152   1997年

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    新潟医学会雑誌   111, 615-619   1997年

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  • p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: Correlation with histologic factors

    Pathology International   47, 531-539   1997年

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    Histopathology   30, 201-207   1997年

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    Pathology International   47, 769-774   1997年

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    総合臨床   46, 247-250   1997年

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  • Occult lymph node metastases detected by cytokeratin immunohistochemistry predict recurrence in 'node-negative' colorectal cancer

    Masataka Sasaki, Hidenobu Watanabe, Jeremy R. Jass, Yoichi Ajioka, Masaaki Kobayashi, Keiji Matsuda, Katsuyoshi Hatakeyama

    Journal of Gastroenterology   32 ( 6 )   758 - 764   1997年

     詳細を見る

    記述言語:英語   出版者・発行元:Springer Tokyo  

    There is controversy about the prognostic significance of occult lymph node metastases detected by immunohistochemistry with the anti-cytokeratin antibody CAM 5.2. The aim of this study was to characterize occult lymph node metastases in colorectal carcinomas that might be associated with a higher risk of recurrence. Three hundred fifty-eight lymph nodes from 10 recurrent and 9 nonrecurrent cases of colorectal carcinoma were examined. All these patients had been reported originally as having no lymph node metastases by routine hematoxylin and eosin staining. Three 10-μm sections or ten 3-μm sections (30-μm total thickness) from each lymph node were stained with CAM 5.2 and examined for the presence of occult lymph node metastases. Occult metastases were detected in 67 of 175 lymph nodes from the recurrent cases, and in 23 of 183 lymph nodes from the nonrecurrent cases. The frequency of positive nodes was significantly higher in the recurrent cases. The recurrent cases had metastases in nodes more distant from the main tumor than did the nonrecurrent cases. Detection of occult lymph node metastases with cytokeratin immunohistochemistry may make it possible to identify patients with a higher risk of recurrence after the removal of a primary colorectal tumor.

    DOI: 10.1007/BF02936951

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  • 大腸癌の発生と進展に関するp53遺伝子変異の意義 -分子生物学的立場から-

    新潟県医師会報   572, 1-6   1997年

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  • Correlation of p53 protein expression with gene mutation in gall-bladder carcinoma

    Pathology International   47, 525-530   1997年

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  • Macroscopic and stereomicroscopic diagnosis of superficial flat-type early carcinomas of the Gallbladder

    J Gastroenterology   32, 635-642   1997年

     詳細を見る

  • MUC1 and MUC2 mucins in flat and polypoid colorectal adenomas

    J Clinical Pathol   50, 417-421   1997年

     詳細を見る

  • adenoma-carcinoma sequenceとde novo cancer

    総合臨床   46, 247-250   1997年

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  • Morphogenesis and development of superficial spreading tumor of the colon and rectum

    Pathology International   47, 769-774   1997年

  • 感染性腸炎の病理

    胃と腸   32, 949-961   1997年

     詳細を見る

  • Occult lymph node metastases detected by cytokeratin immunohistochemistry predict recurrence in 'node-negative' colorectal cancer

    Masataka Sasaki, Hidenobu Watanabe, Jeremy R. Jass, Yoichi Ajioka, Masaaki Kobayashi, Keiji Matsuda, Katsuyoshi Hatakeyama

    Journal of Gastroenterology   32 ( 6 )   758 - 764   1997年

     詳細を見る

    記述言語:英語   出版者・発行元:Springer Tokyo  

    There is controversy about the prognostic significance of occult lymph node metastases detected by immunohistochemistry with the anti-cytokeratin antibody CAM 5.2. The aim of this study was to characterize occult lymph node metastases in colorectal carcinomas that might be associated with a higher risk of recurrence. Three hundred fifty-eight lymph nodes from 10 recurrent and 9 nonrecurrent cases of colorectal carcinoma were examined. All these patients had been reported originally as having no lymph node metastases by routine hematoxylin and eosin staining. Three 10-μm sections or ten 3-μm sections (30-μm total thickness) from each lymph node were stained with CAM 5.2 and examined for the presence of occult lymph node metastases. Occult metastases were detected in 67 of 175 lymph nodes from the recurrent cases, and in 23 of 183 lymph nodes from the nonrecurrent cases. The frequency of positive nodes was significantly higher in the recurrent cases. The recurrent cases had metastases in nodes more distant from the main tumor than did the nonrecurrent cases. Detection of occult lymph node metastases with cytokeratin immunohistochemistry may make it possible to identify patients with a higher risk of recurrence after the removal of a primary colorectal tumor.

    DOI: 10.1007/BF02936951

    Scopus

    PubMed

    researchmap

  • Correlative histochemical study providing evidence for the dual nature of human colorectal cancer mucin

    Histochemical Journal   29, 143-152   1997年

     詳細を見る

  • Failure to detect colonic mucosal hyperproliferation in mutation positive members of family with hereditary non-polyposis colorectal cancer

    Histopathology   30, 201-207   1997年

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    胃と腸   31, 523-537   1996年

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    Human Pathol   27, 1042-1049   1996年

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    Histopathology   28, 543-548   1996年

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  • Assessment of invasive growth pattern and lymphocytic infiltration in colorectal cancer

    Histopathology   28, 543-548   1996年

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    J Clin Pathol   49, 560-564   1996年

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    最新医学   51, 1408-1421   1996年

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    Human Pathol   27, 1042-1049   1996年

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    J Clin Pathol   49, 560-564   1996年

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    胃と腸   30, 629-642   1995年

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    Pathol Int   45, 58-65   1995年

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    Pathol Int   45, 359-365   1995年

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    胃と腸   30, 149-164   1995年

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  • p53 over-expression in neoplastic changes in ulcerative colitis: Immunohisto-chemical Study

    J Gastroenterol   30, 33-35   1995年

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  • Correlation of p53 protein expression with apoptotic incidence in colorectal neoplasia

    Virchows Arch   427, 27-32   1995年

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    Acta Medica et Biologica   43, 197-203   1995年

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  • p53 immunostaining distinguishes malignant from benign lesion of the gall bladder

    Pathol Int   45, 58-65   1995年

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    J Gastroenterol   30, 33-35   1995年

     詳細を見る

  • The proliferating cell nuclear antigen (PCNA) index correlates with the grade of cytologic atypia in well-differentiated early adenocarcinomas of the large intestine

    Pathol Int   45, 359-365   1995年

     詳細を見る

  • Macroscopic characteristics of tubular adenomas in familial adenomatosis coli : relationship between size, gross configuration and location

    Acta Medica et Biologica   43, 63-68   1995年

     詳細を見る

  • Correlation of p53 protein expression with apoptotic incidence in colorectal neoplasia

    Virchows Arch   427, 27-32   1995年

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  • Frequency of p53-positive cells in differing histological phases of ulcerative colitis

    Acta Medica et Biologica   43, 197-203   1995年

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  • 5mm以下の大腸上皮性腫瘍の診断と取り扱い

    胃と腸   30, 1551-1564   1995年

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  • Signet ring cell carcinoma in hyperplastic polyp

    Scand J Gastroenterol   30, 604-608   1995年

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  • 潰瘍性大腸炎に随伴する癌およびdysplasia内の腫瘍性内分泌細胞とパネート細胞ではp53異常蛋白発現と細胞増殖能が消失・著減する

    日本消化器病学会雑誌   92, 1922-1928   1995年

  • 新しい視点からみた胃筋原性腫瘍の病理-Ki-67染色による良・悪性鑑別、分化度と筋原性形質発現および肉腫の発生母地・増悪化

    胃と腸   30, 1109-1123   1995年

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    J Gastroenterol   29, 139-146   1994年

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  • 大腸(微小)腫瘍の肉眼分類-病理の立場から

    胃と腸   29, 89-92   1994年

     詳細を見る

  • Proliferating cell nuclear antigen / cyclin expression in small adenomas of the large intestine in relation to size and macroscopic appearance

    J Gastroenterol   29, 139-146   1994年

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  • 大腸腫瘍の生長速度と生長様式

    消化器内視鏡   6, 1403-1410   1994年

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  • Neoplastic and non-neoplastic intermediate trophoblasts : an immunohistochemical and ultrastructural study

    Pathol Int   44, 57-65   1994年

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  • 早期大腸癌の臨床病理-画像診断のために-

    消化管の癌の画像診断   13, 200-208   1994年

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  • APC and p53 mutations in de novo colorectal adenocarcinoma

    Human Mutation   3, 342-346   1994年

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  • APC and p53 mutations in de novo colorectal adenocarcinoma

    Human Mutation   3, 342-346   1994年

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    Pathol Int   44, 480-485   1994年

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  • DNA image cytometry comparative study of on-tissue and smear sections of human carcinoma

    J Gastroenterol   29, 388   1994年

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  • Ciliated carcinoma of the endometrium associated with mucinous and neuroendocrine differentiation : A case report with immunohistochemical and ultrastructural study

    Pathol Int   44, 480-485   1994年

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  • DNA image cytometry comparative study of on-tissue and smear sections of human carcinoma

    J Gastroenterol   29, 388   1994年

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  • 外科切除・内視鏡的摘除標本の取り扱いと病理診断

    胃と腸   29, 139-147   1994年

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  • Neoplastic and non-neoplastic intermediate trophoblasts : an immunohistochemical and ultrastructural study

    Pathol Int   44, 57-65   1994年

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  • 大腸sm癌の細分類(浸潤度分類)とその問題点

    胃と腸   29, 1117-1125   1994年

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  • Carcinoma of duodenal bulb arising from the Brunner's gland

    Gastroenterol Jpn   28, 118-125   1993年

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  • Nucleolar and dispersed nucleolar organizer regions (NORs) in differentiating neoplastic from atypical non-neoplastic lesions of the pancreas

    Gastroenterol Jpn   28, 72-80   1993年

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  • Diagnostic value of proliferating cell nuclear antigen for myogenic tumors of the stomach

    Gastroentrol Jpn   28, 193-200   1993年

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  • Diagnostic value of proliferating cell nuclear antigen for myogenic tumors of the stomach

    Gastroentrol Jpn   28, 193-200   1993年

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  • Nucleolar and dispersed nucleolar organizer regions (NORs) in differentiating neoplastic from atypical non-neoplastic lesions of the pancreas

    Gastroenterol Jpn   28, 72-80   1993年

     詳細を見る

  • 十二指腸の腫瘍・腫瘍様病変の病理

    胃と腸   28, 627-638   1993年

     詳細を見る

  • Carcinoma of duodenal bulb arising from the Brunner's gland

    Gastroenterol Jpn   28, 118-125   1993年

     詳細を見る

  • Carcinoids and endocrine cell micronests of the minor and major duodenal papillae

    Cancer   70, 1825-1833   1992年

     詳細を見る

  • 大腸癌の組織発生・生長様式

    消化器病セミナー   46, 49-62   1992年

     詳細を見る

  • 異型度と進展様式からみた早期大腸癌

    消化器外科   15, 1321-1328   1992年

     詳細を見る

  • 陥凹型早期大腸癌の生検診断上の問題点-strip biopsyを中心に

    臨床消化器内科   7, 393-402   1992年

     詳細を見る

  • 腸型Behcet病と腸simple ulcerの病理形態像の推移

    胃と腸   27, 276-285   1992年

     詳細を見る

  • Carcinoids and endocrine cell micronests of the minor and major duodenal papillae

    Cancer   70, 1825-1833   1992年

     詳細を見る

  • Histological follow-up of ampullary adenomasa in patients with familial adenomatosis coli

    Cancer   70, 1847-1856   1992年

     詳細を見る

  • 大腸早期癌の肉眼的特徴と病理診断

    MB Gastro   2, 9-18   1992年

     詳細を見る

  • Histological follow-up of ampullary adenomasa in patients with familial adenomatosis coli

    Cancer   70, 1847-1856   1992年

     詳細を見る

  • 小腸の潰瘍性病変の病理概論

    臨床消化器内科   7, 2129-2135   1992年

     詳細を見る

  • A modified argyrophilic nucleolar organizer region (AgNOR) staining method for nucleolar staining in formalin-fixed,paraffin embedded materials

    Gastroenterol Jpn   26, 391   1991年

     詳細を見る

  • 大腸上皮性腫瘍の良・悪性判定におけるnucleolar organizer regionsの有用性

    日本外科学会誌   92, 313-319   1991年

     詳細を見る

  • A modified argyrophilic nucleolar organizer region (AgNOR) staining method for nucleolar staining in formalin-fixed,paraffin embedded materials

    Gastroenterol Jpn   26, 391   1991年

     詳細を見る

  • 病理形態学からみた大腸のびらん

    消化器内視鏡   3, 143-150   1991年

     詳細を見る

  • Use of nucleolar organizer regions in the histopathological diagnosis of colorectal epithelial Neoplasia

    Jpn J Clin Oncol   22, 73-78   1991年

     詳細を見る

  • Use of nucleolar organizer regions in the histopathological diagnosis of colorectal epithelial Neoplasia

    Jpn J Clin Oncol   22, 73-78   1991年

     詳細を見る

  • 小さな大腸癌の意義-早期発見と組織発生の観点から

    消化器内視鏡   2, 969-977   1990年

     詳細を見る

  • 大腸癌・腺腫の病理形態学的検討-癌・腺腫の肉眼鑑別と癌の組織発生について

    新潟医学会雑誌   104, 131-142   1990年

     詳細を見る

  • 炎症性腸疾患の病理学的鑑別-大腸病変を中心に

    胃と腸   25, 659-682   1990年

     詳細を見る

  • 直腸の粘膜脱症候群-病理の立場から

    胃と腸   25, 1301-1311   1990年

     詳細を見る

  • 小さな表面型大腸上皮性腫瘍の病理学的特徴

    胃と腸   2, 837-846   1990年

     詳細を見る

  • Immunohistochemical and ultrastructural studies of twelve argentaffin and six argyrophil carcinoids of the appendix vermiformis

    Human Pathology   21, 773-780   1990年

     詳細を見る

  • 大腸の良悪性境界病変の病理-大腸上皮性腫瘍の新しい組織判定基準による検討

    治療学   24, 1013-1020   1990年

     詳細を見る

  • Immunohistochemical and ultrastructural studies of twelve argentaffin and six argyrophil carcinoids of the appendix vermiformis

    Human Pathology   21, 773-780   1990年

     詳細を見る

  • 大腸高分化腺癌の組織学的判定基準-癌の異型度のバリエーションについて-

    病院病理   7, 38-39   1989年

     詳細を見る

  • 胆嚢癌と胆嚢粘膜の細胞動態

    病理と臨床   7, 1225-1236   1989年

     詳細を見る

  • 潰瘍性大腸炎におけるdysplasia

    Current therapy   7, 238-241   1989年

     詳細を見る

  • 大腸癌の組織発生

    病理と臨床   6, 1035-1042   1988年

     詳細を見る

  • Monoclonal S-100 immunocytochemistry of pigmented naevi with tactile-like corpuscles

    J Pathology   155, 121-126   1988年

     詳細を見る

  • 大腸良悪性境界病変の病理

    病理と臨床   6, 1280-1292   1988年

     詳細を見る

  • Monoclonal S-100 immunocytochemistry of pigmented naevi with tactile-like corpuscles

    J Pathology   155, 121-126   1988年

     詳細を見る

  • Argyrophil,non-argentaffin carcinoids of the appendix vermiformis -Immunohistochemical and ultrastructural studies-

    Acta Pathol Jpn   37, 1237-1247   1987年

     詳細を見る

  • 大腸ポリープと癌

    外科治療   57, 151-160   1987年

     詳細を見る

  • 10mm未満の大腸癌-その肉眼的な特徴と深達度判定法

    胃と腸   22, 412-430   1987年

     詳細を見る

  • Argyrophil,non-argentaffin carcinoids of the appendix vermiformis -Immunohistochemical and ultrastructural studies-

    Acta Pathol Jpn   37, 1237-1247   1987年

     詳細を見る

  • 大腸villous tumor50例の臨床病理学的検討

    胃と腸   21, 1285-1293   1986年

     詳細を見る

  • 潰瘍性大腸炎に大腸の癌、腺腫およびカルチノイドを合併した1例

    胃と腸   21, 951-956   1986年

     詳細を見る

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共同研究・競争的資金等の研究

  • 消化管癌の粘液形質と悪性度

    1998年

      詳細を見る

    資金種別:競争的資金

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  • Mucin phenotype and malignant potential of gastrointestinal carcinomas

    1998年

      詳細を見る

    資金種別:競争的資金

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  • 大腸癌の組織発生と生長様式に関する研究

    1988年

      詳細を見る

    資金種別:競争的資金

    researchmap

  • Inflammatory bowel disease

    1988年

      詳細を見る

    資金種別:競争的資金

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  • Study on Histogenesis and Development of the Colorectal Carcinomas

    1988年

      詳細を見る

    資金種別:競争的資金

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  • 腸の炎症性疾患

    1988年

      詳細を見る

    資金種別:競争的資金

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担当経験のある授業科目

  • 医学序説 II

    2022年
    -
    現在
    機関名:新潟大学

  • 医学序説 I

    2021年
    機関名:新潟大学

  • 臨床医学講義(集中)

    2020年
    -
    現在
    機関名:新潟大学

  • 臓器別講義・演習Ⅰ

    2020年
    -
    現在
    機関名:新潟大学

  • 臓器別講義・演習Ⅱ

    2020年
    -
    現在
    機関名:新潟大学

  • 医学序説 II

    2020年
    機関名:新潟大学

  • 病理総論

    2014年
    機関名:新潟大学

  • 医学研究実習

    2009年
    -
    2010年
    機関名:新潟大学

  • 医科学研究特論

    2009年
    機関名:新潟大学

  • 医科学総合演習

    2009年
    機関名:新潟大学

  • 病気とその原因

    2007年
    -
    現在
    機関名:新潟大学

▶ 全件表示