掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.heliyon.2022.e10034

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.ajoms.2022.08.005

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We investigated the effects of social defeat stress (SDS) and treadmill running on masseter muscle nociception, which was quantified by the orofacial formalin test and c-Fos and FosB immunoreactivities in the upper cervical spinal cord (C1/C2) region in male mice. After daily SDS or non-SDS conditioning for 10 days, SDS-conditioned mice were categorized into SDS-susceptible versus resilient mice. Several mice, including non-SDS-conditioned, SDS-susceptible, and resilient mice, were selected to assess masseter muscle nociception on Day 11. SDS conditioning for 10 days increased masseter muscle-evoked nocifensive behaviors and c-Fos and FosB expression in SDS-susceptible compared to non-SDS and resilient mice. The remaining SDS-susceptible and non-SDS mice were subjected to an additional 10 days of SDS plus treadmill running or sedentary sessions before assessing masseter muscle nociception on Day 21. Daily treadmill running sessions reduced enhanced masseter muscle nociception in SDS-susceptible mice but not in non-SDS mice. The preventive effects of daily treadmill running immediately after each SDS conditioning for 10 days on orofacial nocifensive behaviors were assessed on Day 11. Treadmill running conducted immediately after daily SDS inhibited enhanced orofacial nocifensive behaviors. These findings indicate that repeated SDS increases masseter muscle nociception, which could be prevented by daily treadmill running exercise.

DOI： 10.1111/eos.12882

PubMed

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers Media SA  

The periodontal ligament (PDL) is a specialized connective tissue that provides structural support to the tooth and is crucial for oral functions. The mechanical properties of the PDL are mainly derived from the tissue-specific composition and structural characteristics of the extracellular matrix (ECM). The ECM also plays key roles in determining cell fate in the cellular microenvironment thus crucial in the PDL tissue homeostasis. In the present study, we determined the comprehensive ECM profile of mouse molar PDL using laser microdissection and mass spectrometry-based proteomic analysis with ECM-oriented data curation. Additionally, we evaluated changes in the ECM proteome under mechanical loading using a mouse orthodontic tooth movement (OTM) model and analyzed potential regulatory networks using a bioinformatics approach. Proteomic changes were evaluated in reference to the novel second harmonic generation (SHG)-based fiber characterization. Our ECM-oriented proteomics approach succeeded in illustrating the comprehensive ECM profile of the mouse molar PDL. We revealed the presence of type II collagen in PDL, possibly associated with the load-bearing function upon occlusal force. Mechanical loading induced unique architectural changes in collagen fibers along with dynamic compositional changes in the matrisome profile, particularly involving ECM glycoproteins and matrisome-associated proteins. We identified several unique matrisome proteins which responded to the different modes of mechanical loading in PDL. Notably, the proportion of type VI collagen significantly increased at the mesial side, contributing to collagen fibrogenesis. On the other hand, type XII collagen increased at the PDL-cementum boundary of the distal side. Furthermore, a multifaceted bioinformatics approach illustrated the potential molecular cues, including PDGF signaling, that maintain ECM homeostasis under mechanical loading. Our findings provide fundamental insights into the molecular network underlying ECM homeostasis in PDL, which is vital for clinical diagnosis and development of biomimetic tissue-regeneration strategies.

DOI： 10.3389/fphys.2022.899699

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

当院の二段階口蓋形成手術法では、軟口蓋形成術をFurlow法により1歳半に、硬口蓋閉鎖術を鋤骨弁により4歳に施行している。軟口蓋形成術後の硬口蓋残遺裂には硬口蓋閉鎖床を装着しているが、この間の言語機能の獲得には否定的な影響が懸念されやすい。本研究では、当院の治療体系における口蓋化構音の発現要因を明らかにし、口蓋化構音の発現を予防することを目的として、まず、軟口蓋形成術後の1歳半から硬口蓋閉鎖術前の4歳までを幼児期前期とし、片側完全唇顎口蓋裂16例の幼児期前期の言語発達過程でみられた言語症状を回顧的に評価し、良好群、口蓋化構音群(以下、口蓋化群)、不良群の3群に類型化した。そして、類型化した群ごとに、言語機能の獲得状況と硬口蓋残遺裂を含めた上顎歯槽弓形態の関連性について検討した。その結果、口蓋化群の2歳の硬口蓋残遺裂後端の位置に関連性が示され、硬口蓋残遺裂後端や軟口蓋からの漏れを補おうとする舌の誤学習が、口蓋化構音の発現に影響を与えている可能性が推察された。また、得られた結果にもとづき、言語機能をできる限り向上させるため、幼児期前期の言語管理の進め方について再考した。(著者抄録)

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

Orthognathic Quality of Life Questionnaire(OQLQ)日本語版を作成し、その信頼性と妥当性を検証した。顎変形症初診患者22名(男性2名、女性20名、平均20.1±8.7歳)から回答を得た。言語的妥当性について対象者はすべて15分以内に回答を終えていた。用いた言語については「咀嚼という言葉が少し分かりづらかった」との指摘が2名からあったが回答はできており、すべての質問の回答率は100%であった。項目テスト相関係数は-0.01から0.68であった。口腔機能(OF)に相関が低い質問項目があったが、各質問項目のCronbachのα係数は0.79〜0.82といずれも高く、口腔機能を示す質問も内的整合性は良好であった。また、SF-8の身体的サマリースコアとそれに関連する下位尺度の相関係数は-0.428〜0.004であり、OQLQのOFと相関を認める下位尺度があったが、その他三つの要素との関連は認めなかった。開発した日本語版OQLQは顎変形症患者の疾患関連QOLの尺度として信頼性があり、妥当性もあると考えられた。

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J03047&link_issn=&doc_id=20220510230003&doc_link_id=1390573407618666496&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390573407618666496&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

OBJECTIVES: The ciliopathies are a wide spectrum of human diseases, which are caused by perturbations in the function of primary cilia. Tooth enamel anomalies are often seen in ciliopathy patients; however, the role of primary cilia in enamel formation remains unclear. MATERIALS AND METHODS: We examined mice with epithelial conditional deletion of the ciliary protein, Ift88, (Ift88fl / fl ;K14Cre). RESULTS: Ift88fl / fl ;K14Cre mice showed premature abrasion in molars. A pattern of enamel rods which is determined at secretory stage, was disorganized in Ift88 mutant molars. Many amelogenesis-related molecules expressing at the secretory stage, including amelogenin and ameloblastin, enamelin, showed significant downregulation in Ift88 mutant molar tooth germs. Shh signaling is essential for amelogenesis, which was found to be downregulated in Ift88 mutant molar at the secretory stage. Application of Shh signaling agonist at the secretory stage partially rescued enamel anomalies in Ift88 mutant mice. CONCLUSION: Findings in the present study indicate that the function of the primary cilia via Ift88 is critical for the secretory stage of amelogenesis through involving Shh signaling.

DOI： 10.1111/odi.14162

PubMed

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/odi.14162

記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

<title>Abstract</title>Periodontal ligament (PDL) is a uniquely differentiated tissue that anchors the tooth to the alveolar bone socket and plays key roles in oral function. PDL cells can respond rapidly to mechanical stimuli, resulting in accelerated tissue remodeling. Cell proliferation is an initial event in tissue remodeling and participates in maintaining the cell supply; therefore, analyzing cell-proliferative activity might provide a comprehensive view of cellular dynamics at the tissue level. In this study, we investigated proliferating cells in mouse molar PDL during orthodontic tooth movement (OTM)-induced tissue remodeling. Our results demonstrated that the mechanical stimuli evoked a dynamic change in the proliferative-cell profile at the entire PDL. Additionally, cell-tracing analysis revealed that the proliferated cells underwent further division and subsequently contributed to tissue remodeling. Moreover, OTM-induced proliferating cells expressed various molecular markers that most likely arise from a wide range of cell types, indicating the lineage plasticity of PDL cells in vivo. Although further studies are required, these findings partially elucidated the global views of the cell trajectory in mouse molar PDL under mechanical-loading conditions, which is vital for understanding the cellular dynamics of the PDL and beneficial for dental treatment in humans.

DOI： 10.1038/s41598-021-89156-w

PubMed

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その他リンク： http://www.nature.com/articles/s41598-021-89156-w

記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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掲載種別：研究論文（学術雑誌）  

Wnt signaling plays a critical role in the development of many organs, including the major movable craniofacial organs tongue, lip, and eyelid. Four members of the R-spondin family (Rspo1-4) bind to Lgr4/5/6 to regulate the activation of Wnt signaling. However, it is not fully understood how Rspos/Lgrs regulate Wnt signaling during the development of movable craniofacial organs. To address this question, we examined the expression of Rspos, Lgrs, and Axin2 (major mediator of canonical Wnt signaling) during tongue, lip, and eyelid development. The expression of Axin2, Rspos and Lgrs was observed in many similar regions, suggesting that Rspos likely activate canonical Wnt signaling through the Lgr-dependent pathway in these regions. Lgr expression was not detected in regions where Axin2 and Rspos were expressed, suggesting that Rspos might activate canonical Wnt signaling through the Lgr-independent pathway in these regions. In addition, the expression of Rspos and Lgrs were observed in some other regions where Axin2 was not expressed, suggesting the possibility that Rspos and/or Lgrs are involved in non-canonical Wnt signaling or the Wnt-independent pathway. Thus, we identified a dynamic spatiotemporal expression pattern of Rspos and Lgrs during the development of the eyelid, tongue, and lip.

DOI： 10.1016/j.gep.2021.119195

PubMed

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Informa UK Limited  

DOI： 10.1080/13440241.2021.1937785

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：日本結合組織学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

DOI： 10.1002/osi2.1111

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1111

記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

Mandibular anomalies are often seen in various congenital diseases, indicating that mandibular development is under strict molecular control. Therefore, it is crucial to understand the molecular mechanisms involved in mandibular development. MicroRNAs (miRNAs) are noncoding small single-stranded RNAs that play a critical role in regulating the level of gene expression. We found that the mesenchymal conditional deletion of miRNAs arising from a lack ofDicer(an essential molecule for miRNA processing,Dicer(fl)(/)(fl);Wnt1Cre), led to an abnormal groove formation at the distal end of developing mandibles. At E10.5, when the region forms, inhibitors of Hh signaling,Ptch1andHhip1showed increased expression at the region inDicermutant mandibles, whileGli1(a major mediator of Hh signaling) was significantly downregulated in mutant mandibles. These suggest that Hh signaling was downregulated at the distal end ofDicermutant mandibles by increased inhibitors. To understand whether the abnormal groove formation inDicermutant mandibles was caused by the downregulation of Hh signaling, mice with a mesenchymal deletion of Hh signaling activity arising from a lack ofSmo(an essential molecule for Hh signaling activation,Smo(fl)(/)(fl);Wnt1Cre) were examined.Smo(fl)(/)(fl);Wnt1Cremice showed a similar phenotype in the distal region of their mandibles to those inDicer(fl)(/)(fl);Wnt1Cremice. We also found that approximately 400 miRNAs were expressed in wild-type mandibular mesenchymes at E10.5, and six microRNAs were identified as miRNAs with binding potential against bothPtch1andHhip1. Their expressions at the distal end of the mandible were confirmed byin situhybridization. This indicates that microRNAs regulate the distal part of mandibular formation at an early stage of development by involving Hh signaling activity through controlling its inhibitor expression level.

DOI： 10.1111/joa.13328

Web of Science

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/joa.13328

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

Purpose: Obstructive sleep apnea (OSA) is generally more common in men than in women, so many studies have only involved male OSA patients as subjects. However, a certain proportion of OSA patients are female, and few studies have addressed this population. Maxillofacial morphology and obesity are now being shown to be intimately connected with OSA, but the details remain unclear. The objective of this retrospective study was to identify the clinical features of OSA in men and women of different ages, with a focus on maxillofacial morphology and body mass index (BMI).Methods: The subjects comprised 112 patients (56 men and 56 women) randomly selected from adult patients in the Niigata University Medical and Dental Hospital. We investigated the results of lateral cephalogram measurements and polysomnography (PSG) conducted before the start of OSA treatment. We then divided the patients by age (with 50 years as the cutoff value) and sex, and performed statistical comparisons among these four groups.Results: The findings showed that the hyoid bone was lower in men aged >= 50 compared with <50, and the cross-sectional area of the tongue was larger. This suggested that aging changes in maxillofacial morphology may be a risk factor in men. In women, however, only slight morphological differences were found between the two age groups.Conclusions: This comparative study of sex and age groups in OSA patients suggests that the different groups have different clinical characteristics and may have different risk factors for developing OSA.

DOI： 10.1002/osi2.1061

Web of Science

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1061

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Scientific Scholar  

<sec id="st1">
<title>Objectives:</title>
The objective of the study was to clarify the changes in vermilion lip morphology following orthodontic treatment in Japanese patients with Class II maxillary protrusion.


</sec>
<sec id="st2">
<title>Materials and Methods:</title>
The subjects were 15 adult women diagnosed as having Angle Class II maxillary protrusion who had undergone orthodontic treatment with premolar extraction. For analysis, profile photographs taken at the first examination and at completion of active treatment were used for linear and angular measurements. For linear measurements on the lateral facial photographs, an X–Y coordinate system was established using a lateral cephalogram superimposed along the line of the profile. Measurement points relating to the vermilion lip morphology were measured on the facial photographs by digital processing, with the Frankfort horizontal (FH) plane as the X-axis, and the line perpendicular to the X-axis passing through the alar curvature point (Ac) as the Y-axis.


</sec>
<sec id="st3">
<title>Results:</title>
The results of linear measurements showed significant retraction of approximately 3.0 mm in the upper vermilion lip, and mean retraction of the upper incisors after treatment was approximately 6.0 mm. However, whereas mean retraction of the lower incisors was approximately 1.0 mm, there was significant retraction of the lower vermilion lip of over 3.0 mm. Significant reduction in vermilion height was also found in the upper vermilion lip. With regard to angular measurements, the upper lip and total vermilion showed significant reductions that indicated inversion.


</sec>
<sec id="st4">
<title>Conclusion:</title>
Adequate retraction of the upper incisors in the maxillary protrusion with excessive overjet may retract not only the upper vermilion lip but also the lower one, suggesting that morphological changes in the lower lip are affected by the positioning of the upper incisors. In addition, the patterns of morphological changes differed between the upper and lower vermilion lips, with a large proportion of rotational change toward the mucous membrane in the upper vermilion lip and with a pattern of change resembling horizontal displacement in the lower vermilion lip. Total vermilion showed a significant reduction in vermilion height due to the reduction in height of the upper vermilion lip.


</sec>

DOI： 10.25259/apos_63_2020

Web of Science

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掲載種別：研究論文（学術雑誌）  

© 2020 Elsevier Inc. Osteoclast and osteoblast are essential for proper bone development and remodeling as well as recovery of bone fracture. In this study, we seek chemical compounds that enhance turnover of bone metabolism for promoting bone healing. First, we screen a chemical library which includes 378 compounds by using murine pre-osteoclastic RAW264.7 cells to identify compounds that promote osteoclastic differentiation. We find that two ROCK (Rho-associated coiled-coil kinase) inhibitors, HA-1077 (Fasudil) and Y-27632, enhance osteoclastogenesis. Subsequently, we identify that these two compounds also increase osteoblastic differentiation of MC3T3-E1 cells. Finally, our in vivo experiment shows that the local administration of ROCK inhibitors accelerate the bone healing of the rat calvarial defect.

DOI： 10.1016/j.bbrc.2020.03.033

Scopus

PubMed

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：(公社)日本口腔外科学会  

質的研究を用いて顎変形症患者自身の考えや経験、その相互作用について検討することで、外科的矯正治療を決意し治療が終了するまでの心理・社会的変化のプロセスおよびその構造を明らかにすることを目的とした。対象は当院口腔再建外科で外科的矯正治療を施行した女性患者6名(未成年3名、成人3名)であった。患者の考えや経験、それらによる心理・社会的な影響と変化のプロセスを明らかにするため回顧的に面接調査を行い、グラウンデッド・セオリー・アプローチにより分析した。その結果、悩みが大きく変化する時期について4個のコアカテゴリー「成長過程での顔貌、咬合の変化に対する悩みの変化」「治療決断に至る心理社会的葛藤」「治療に伴う苦痛とそれを乗り越える術後への前向きな気持ち」「悩みや葛藤からの解放」が生成された。患者が悩みを抱く過程、治療に対する身体的・心理的苦難を乗り越える過程、さらに治療後の心理・社会的な変化の過程には友人、家族、同病者が大きく影響を及ぼしていることが明らかとなった。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01073&link_issn=&doc_id=20200515550001&doc_link_id=10.5794%2Fjjoms.66.178&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.66.178&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

BACKGROUND: Periodic patterning of iterative structures is diverse across the animal kingdom. Clarifying the molecular mechanisms involved in the formation of these structures helps to elucidate the genetic commonality of developmental processes, as organs with these structures are believed to share the same molecular mechanisms and fundamental processes. Palatal rugae are periodic corrugated structures on the hard palate and are conserved in all mammals. Although the numbers and patterns of the palatal rugae are species specific, they are consistent in each mammalian species, except humans. HIGHLIGHT: Palatal rugae development is thus under strict genetic control in most mammals and is an excellent model to investigate the genetic commonality of developmental processes to form periodic patterning. CONCLUSION: This review highlights the current understanding of the molecular mechanisms of palatal rugae development.

DOI： 10.1016/j.job.2019.12.002

PubMed

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記述言語：日本語   出版者・発行元：(一社)日本形成外科学会  

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記述言語：日本語   出版者・発行元：(一社)日本形成外科学会  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：(NPO)日本顎変形症学会  

外科的矯正治療症例と矯正歯科治療単独症例を対象に、Index of Orthognathic Functional Treatment Need(IOFTN)を用いて各治療法のボーダーラインについて検証した。顎変形症の診断で外科的矯正治療を行ったSO群92名(男性29名、女性63名、平均24±8歳)とスケルタル・アンカレッジ併用の矯正歯科治療を行ったSA群41名(男性13名、女性28名、平均26±8歳)、それ以外の矯正歯科治療を行ったCO群51名(男性19名、女性32名、平均23±8歳)を対象とした。診療録、頭部X線規格写真、研究用模型等を用いてIOFTNに準じてCategory 1(none)からCategory 5(very great)の5段階に分類した。Category分類の結果では、SO群で最も多かったのはCategory 4の44例、次いでCategory 5の42例で、両者で手術群の9割以上を占めていた。SA群ではCategory 4が18例と最も多く、その他のCategoryはほぼ同数であった。CO群はCategory 1の22例が最多で、ついでCategory 4の17例となっており、二峰性のピークを認めた。

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記述言語：日本語   出版者・発行元：新潟歯学会  

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記述言語：日本語   出版者・発行元：新潟歯学会  

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記述言語：日本語   出版者・発行元：新潟歯学会  

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記述言語：日本語   出版者・発行元：新潟歯学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：英語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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担当区分：最終著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：(一社)日本口蓋裂学会  

本研究の目的は、術前鼻歯槽形成(以下、PNAM)治療による外鼻形態への短期的効果を明らかにすることである。今回、我々はPNAM治療開始時から口唇形成術後約6ヵ月まで経時的に評価を行ったので報告する。対象は新潟大学医歯学総合病院(以下、当院)にて出生時から治療管理を開始した片側口唇口蓋裂患者17例のうちPNAM治療を行った12例(男児6例、女児6例)をPNAM群とし、PNAM治療を行っていない5例(男児2例、女児3例)をnon-PNAM群とした。資料として、正面および鼻孔位にて、初回資料採得時(T1)および口唇形成直前(T2)、口唇形成後(T3)の3時点で撮影した顔面写真を用いた。6つの計測項目を設定し、両群間におけるT1、T2、T3での平均値、およびT1-T2、T2-T3での変化量について統計学的に比較検討した。T1では、PNAM群とnon-PNAM群において全項目で有意な差を認めなかった。T2では、non-PNAM群に対しPNAM群で鼻尖傾斜角、鼻柱傾斜角が有意に小さな値を、患側鼻孔上縁角が有意に大きな値を示した。これに対し、T3では、正面鼻翼基部傾斜角においてのみ、PNAM群が有意に小さな値を示した。T1-T2およびT2-T3における変化では、PNAM群でT1-T2、T2-T3の両方で有意な変化が認められたのに対し、non-PNAM群ではおもにT2-T3において有意な変化が示され、T1-T2では有意な変化は認めなかった。これはnon-PNAM群では術前の外鼻変形の大半を口唇形成術のみによって改善していることを意味していると考えられた。以上のことから、当院におけるPNAM治療は術前における鼻翼基部の偏位の改善に寄与していた。しかし、術後における外鼻形態への影響は認められず、PNAM治療の効果について検討を行うためには今後さらなる検討が必要と考えられた。(著者抄録)

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: Tongue thrusting, which often occurs during swallowing in patients with anterior open bite, is considered to show different tongue dynamics from healthy individuals, but the details are still unclear. OBJECTIVE: This study aimed to identify the effect of tongue thrusting on tongue pressure production during swallowing in patients with anterior open bite. METHODS: The subjects were 11 patients with an anterior open bite and 8 healthy volunteers with individual normal occlusion. The patients were divided into a tongue-thrusting group (n = 8) and a non-thrusting group (n = 3). Tongue pressures while swallowing jelly (4 mL) were recorded by a sensor sheet system with five measuring points (Chs1-5) attached to the palatal mucosa. The time sequences, maximum magnitude and duration of tongue pressure, and swallowing time of tongue pressure were analysed. RESULTS: Tongue pressure waveforms in the tongue-thrusting group were quite diverse compared with the other two groups. The duration at the posterior-median part in the tongue-thrusting group was significantly shorter, and the maximum magnitudes at the mid-median, posterior-median and the peripheral part were also significantly lower than in the healthy group. These results suggest that the compensatory tongue thrust action by which the tongue closes the front part of the oral cavity may make it difficult to lift the tongue and transfer the bolus. CONCLUSION: Patients with an anterior open bite and tongue thrusting at swallowing showed diversity of tongue pressure waveforms and noticeably weaker tongue pressures from mid-median to posterior-median regions than healthy individuals.

DOI： 10.1111/joor.12820

PubMed

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記述言語：日本語   出版者・発行元：(NPO)日本睡眠歯科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

短時間で計測可能な全自動咀嚼能力測定装置を用いて、骨格性下顎前突症患者の咀嚼能力と顎顔面形態との関連について検討した。骨格性下顎前突症と診断された10名(男性5名、女性5名、平均16.6歳)、個性正常咬合者10名(男性2名、女性8名、平均24.1歳)を対象とした。咀嚼能率の平均は健常群で5204.8±660.9mm2、下突群で2919.9±578.3mm2となり、下突群が有意に低い値を示した。下突群の咀嚼能率と咬合接触面積、咀嚼能率と最大咬合力との間には有意な相関は認められなかったが、咀嚼能率と咀嚼時間との間に有意な正の相関を認めた。また、下突群の咀嚼能率とGonial angle、咀嚼能率と前下顔面高との間に有意な負の相関を認めたが、咬合接触面積と側面頭部X線規格写真の各計測値との間に有意な相関は認められなかった。一方、最大咬合力と下顎骨体長、下顎骨長との間には有意な正の相関を認めた。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J03047&link_issn=&doc_id=20190827290002&doc_link_id=%2Fdh5jawdf%2F2019%2F002903%2F002%2F0237-0246%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdh5jawdf%2F2019%2F002903%2F002%2F0237-0246%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

骨格性下顎前突症患者を対象として超音波断層法による嚥下時舌運動様相の測定を行い、個性正常咬合者と比較検討した。外科的矯正治療の適応症と診断された骨格性下顎前突症患者10名(男性6名、女性4名、平均20.6±7.4歳)、個性正常咬合者10名(男性2名、女性8名、平均21.5±4.0歳)を対象とした。嚥下時舌運動をみると、舌中央部において、健常群では舌安静位から急速に舌表面が下降して陥凹形成した後、口蓋へと挙上し、再度、舌安静位へと戻っていた。下突群では、波形の性状は健常群とほぼ同様であったが、舌の口蓋への挙上は緩やかに行われていた。舌周縁部においては、健常群では舌中央部が陥凹形成を開始した時点から舌表面の滑らかな挙上と下降を示したが、下突群では長時間にわたり持続的な上下動を呈しており、このことは下突群すべての被験者において認められた。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J03047&link_issn=&doc_id=20190827290001&doc_link_id=%2Fdh5jawdf%2F2019%2F002903%2F001%2F0229-0236%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdh5jawdf%2F2019%2F002903%2F001%2F0229-0236%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：(NPO)日本顎変形症学会  

顎矯正手術を施行した骨格性下顎前突症患者10名(全例女性)を対象に、舌圧センサシートを用いて舌の機能的特徴を解析し、過去に報告した個性正常咬合者10名および骨格性下顎前突症患者(顎矯正手術施行前)10名の結果と比較することで術後における嚥下時舌動態の傾向について検討した。術後6ヵ月経過した症例の舌圧波形は各Chの舌圧発現からそれぞれ約200〜400msec後にピーク値をむかえたが、その後もピーク値に近似した舌圧が持続的に働いた。術後群の舌圧発現順序は、舌圧発現開始時刻よりCh1、Ch4、Ch5、Ch2、Ch3の順となり健常群と同じ順序であった。舌圧発現開始時刻、舌圧ピーク発現時刻は健常群と比較し有意差を認めなかったが、Ch4、Ch5における舌圧消失時刻は遅延した。そのため、Ch4、Ch5の舌圧持続時間の延長という下突群と同じ特徴を有していたが、術後群と下突群を比較するとCh4、Ch5における舌圧消失時刻は有意に早期化していた。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J03047&link_issn=&doc_id=20190507340006&doc_link_id=130007649442&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007649442&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：(NPO)日本顎変形症学会  

外科的矯正治療の適応の指標であるIndex of Orthognathic Functional Treatment Need(IOFTN)の日本人における有用性について検証した。当科で顎矯正手術を施行した顎変形症患者128名(男性37名、女性91名、平均23±8歳)を対象とした。IOFTN分類の結果で最も多かったのはvery greatであるCategory 5の61例(47.7%)で、次いでgreatであるCategory 4の57例(44.5%)、moderateであるCategory3の10例(7.8%)の順であった。対象の症型分類で最も多かったのはClass 3の82例(64.1%)で、男女ともClass 3が対象の大半を占めていた。一方、Class 1は29例(22.7%)、Class 2においては17例(13.3%)しか認めなかった。症型分類とIOFTNとの関連について検討したところ、Class 1では顔面非対称を呈するCategory 4.10が10例(34.5%)と最多であったが、反対咬合を呈する症例が9例、上顎前歯部の前突を呈するCategory 4.2(1例)、開咬を呈するCategory 5.4、Category 4.4ならびにCategory 3.4(計3例)なども認めた。Class 2はCategory 5.2およびCategory 4.2の上顎前突または下顎後退症を呈する症例が7例と41.2%を占めていた。

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：日本歯科医学会  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   出版者・発行元：新潟歯学会  

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記述言語：日本語   出版者・発行元：新潟歯学会  

ビスフォスフォネート(BP)製剤関連顎骨壊死(BRONJ)は広く認知されるようになってきたが、BPの投与を受ける患者に対して顎矯正手術を行った報告は少ない。今回われわれは、BPを内服する患者に対して顎矯正手術を行ったので報告する。患者は16歳男性で不正咬合を主訴に当科を受診した。骨格性下顎前突症の診断となり、顎矯正手術を計画したが、術前矯正治療終了後に多発性硬化症の診断に至り、ステロイドの内服治療が開始され、ステロイド性骨粗鬆症の予防のためにBPの内服も開始された。治療により多発性硬化症の症状の出現はなく、ステロイドは減量されていった。19歳時に、BPを6ヵ月間休薬し、Le Fort I型骨切り術と下顎枝矢状分割法による顎矯正手術を行って、9ヵ月後にプレート除去を行い、BPを再開した。周術期は感染に留意し、BRONJの発症はなかった。顎矯正手術後2年が経過した現在も経過観察中であるが、異常経過は認めていない。(著者抄録)

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記述言語：日本語   出版者・発行元：新潟歯学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：克誠堂出版(株)  

CiNii Article

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2018335806

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier Ltd  

Purpose: A nationwide collaborative survey was performed in Japan to evaluate the recent treatment outcomes on occlusion after orthodontic/orthognathic treatment for patients with unilateral cleft lip and palate (UCLP). Methods: A retrospective collaborative survey was performed. Twenty-five facilities, including 14 university hospitals, examined their orthodontic records and cast models of patients with UCLP. Using common format, information of 492 non-syndromic UCLP cases were reported. Patients with syndromic UCLP or congenital missing maxillary central incisors were excluded. Basically, each facility reported their most recent 30 cases. Results: Of 492 cases, 330 cases (67.1%) were reported from 11 facilities, suggesting that orthodontic treatment for patients with CL/P was not fully centralized in Japan. Secondary alveolar bone grafting and orthognathic surgery were performed in 92.7% and 22.5% of cases, respectively. A significantly higher rate of orthognathic surgery was seen in cases reported from university hospitals (27.5%) than other facilities (14.8%). Average age at the end of active orthodontic/orthognathic treatment was 18.5 years. The lateral incisors on cleft sides were congenitally missing in 50.2% and displayed microdontia in 42.9% of cases. After orthodontic treatment, the central incisors and the canines were aligned without interdental spaces in 55.3% of cases. The positive anterior overjet was seen in 88.2%, and the centerline discrepancies between maxillary and mandibular incisors within 1/4 of mandibular incisor width was in 74.8% of cases. Conclusions: The final occlusion after orthodontic treatment was satisfactory in most cases. Findings of this study are referable for improving standard Japanese orthodontic care for patients with CL/P.

DOI： 10.1016/j.odw.2018.02.003

Scopus

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier Ltd  

Purpose: This six-clinic collaborative study collected patient opinions after orthodontic treatment, for quality improvement. Materials and methods: Participants comprised 477 patients with unilateral cleft lip and palate (UCLP) who had undergone orthodontic treatment at orthodontic clinics in five university hospitals and one private office in Japan. The questionnaire sent to patients contained 33 questions in five categories, about the respondent, before, during and after orthodontic treatment, and overall treatment. Questionnaires were returned by mail anonymously. Results: Responses were received from 183 patients (response rate, 38.4%). Patients tended to anticipate esthetic improvements in anterior teeth and facial appearance, and reported great improvements with orthodontic treatment. Masticatory problems also improved and orthodontic treatment had positive effects on speech. Almost all respondents were satisfied with orthodontic treatment. Problems with overall treatment were long treatment period, difficulty attending clinics and maintenance of oral hygiene during treatment. Conclusion: This study clarified the subjective effects and problems with orthodontic treatment in patients with UCLP in Japan. Satisfaction after treatment was high. Anticipated esthetic improvement was accomplished and masticatory problems improved. Orthodontic treatment also positively affected speech. Efficient orthodontic treatment to minimize treatment duration and improved treatment systems for easier access are needed to reduce patient burdens in Japan.

DOI： 10.1016/j.odw.2018.02.002

Scopus

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

This study aimed to analyze the mRNA expression and protein localization of prostaglandin I2 (PGI2) synthase (PGIS), the PGI2 receptor (IP receptor) and transient receptor potential cation channel, subfamily V, member 1 (TRPV1) in force-stimulated rat molars, toward the elucidation of the PGI2-IP receptor-TRPV1 pathway that is in operation in the pulp and possibly associated with orthodontic pain and inflammation. Experimental force was applied to the maxillary first and second molars by inserting an elastic band between them for 6-72 h. PGIS, PTGIR (the IP receptor gene), and TRPV1 mRNA levels in the coronal pulp were analyzed with real-time PCR. PGIS, IP receptor, and TRPV1 proteins were immunostained. The force stimulation induced significant upregulation of PGIS at 6-24 h, and PTGIR and TRPV1 at 6 and 12 h in the pulp. PGIS was immunolocalized in odontoblasts and some fibroblasts in the force-stimulated pulp. The IP receptor and TRPV1 immunoreactivities were detected on odontoblasts and some nerve fibers. It was concluded that PGIS, PTGIR, and TRPV1 in rat molar pulp were significantly upregulated shortly after the force application, and that the IP receptor was co-expressed on TRPV1-expressing nerves and odontoblasts. These findings suggest that the PGI2-IP receptor-TRPV1 pathway is associated with the acute phase of force-induced pulp changes involving odontoblasts and nerves.

DOI： 10.1007/s10266-017-0309-2

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

This study aimed to analyze the mRNA expression and protein localization of prostaglandin I2 (PGI2) synthase (PGIS), the PGI2 receptor (IP receptor) and transient receptor potential cation channel, subfamily V, member 1 (TRPV1) in force-stimulated rat molars, toward the elucidation of the PGI2-IP receptor-TRPV1 pathway that is in operation in the pulp and possibly associated with orthodontic pain and inflammation. Experimental force was applied to the maxillary first and second molars by inserting an elastic band between them for 6-72 h. PGIS, PTGIR (the IP receptor gene), and TRPV1 mRNA levels in the coronal pulp were analyzed with real-time PCR. PGIS, IP receptor, and TRPV1 proteins were immunostained. The force stimulation induced significant upregulation of PGIS at 6-24 h, and PTGIR and TRPV1 at 6 and 12 h in the pulp. PGIS was immunolocalized in odontoblasts and some fibroblasts in the force-stimulated pulp. The IP receptor and TRPV1 immunoreactivities were detected on odontoblasts and some nerve fibers. It was concluded that PGIS, PTGIR, and TRPV1 in rat molar pulp were significantly upregulated shortly after the force application, and that the IP receptor was co-expressed on TRPV1-expressing nerves and odontoblasts. These findings suggest that the PGI2-IP receptor-TRPV1 pathway is associated with the acute phase of force-induced pulp changes involving odontoblasts and nerves.

DOI： 10.1007/s10266-017-0309-2

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SAGE Publications Ltd  

Objective: To understand the actual condition of orthodontic treatment in team care for patients with syndromic craniosynostosis (SCS) in Japan. Design: A nationwide collaborative survey. Setting: Twenty-four orthodontic clinics in Japan. Patients: A total of 246 patients with SCS. Main Outcome Measure: Treatment history was examined based on orthodontic records using common survey sheets. Results: Most patients first visited the orthodontic clinic in the deciduous or mixed dentition phase. Midface advancement was performed without visiting the orthodontic clinic in about a quarter of the patients, and more than a half of the patients underwent “surgery-first” midface advancement. First-phase orthodontic treatment was carried out in about a half of the patients, and maxillary expansion and protraction were performed. Tooth extraction was required in about two-thirds of patients, and the extraction of maxillary teeth was required in most patients. Tooth abnormalities were found in 37.8% of patients, and abnormalities of maxillary molars were frequently (58.3%) found in patients who had undergone midface surgery below the age of 6 years. Conclusions: Many patients underwent “surgery-first” midface advancement, and visiting the orthodontic clinic at least before advancement was considered desirable. First-phase orthodontic treatment should be performed considering the burden of care. Midface advancement below the age of 6 years had a high risk of injury to the maxillary molars. This survey is considered useful for improving orthodontic treatment in team care of patients with SCS.

DOI： 10.1177/1055665617747703

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier Ltd  

Objective: The aim of this study was to determine the effects of maxillomandibular movements by orthognathic surgery on nasal and oronasopharyngeal airway morphologies and nasal respiratory function. Methods: The subjects were 32 patients in whom jaw deformities were corrected by two jaw surgery. The amount of jaw movements was evaluated on cephalograms taken before surgery and more than six months after surgery, and morphological changes were evaluated using helical computed tomography (CT), and nasal airway resistance (NAR) for the objective evaluation of nasal respiratory function was measured by anterior rhinomanometry. The results showed that the volume of the nasal cavity and NAR was not changed significantly after surgery. However, the change of NAR was negatively correlated with changes of nasopharyngeal volume and the cross-sectional area in the palatal section (P-CSA). The change of NAR correlated with horizontal movement at B-point. Furthermore, the amount of vertical movement of the maxilla at the posterior nasal spine (PNS) was significantly correlated with reductions in the volume of the oropharynx upper region. Conclusion: There was little association of changes in maxillomandibular position or nasal and oronasopharyngeal airway morphologies with nasal respiratory function. This might be because of compensatory biomedical action to maintain nasal respiratory function.

DOI： 10.1016/j.ajoms.2017.11.011

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Nihon University, School of Dentistry  

Current therapeutics are not effective for orofacial neuropathic pain, and better options are needed. The present study used inferior orbital nerve (ION)-injured mice to investigate the effect of inhibiting monoacylglycerol lipase (MAGL), an enzyme that degrades the major endocannabinoid 2-arachydonoylgycerol (2-AG) in orofacial neuropathic pain. The head-withdrawal threshold to mechanical stimulation of the whisker pad was reduced on days 3, 5, and 7 after ION injury. Injection of JZL184, a selective inhibitor of MAGL, on day 7 after ION injury attenuated the reduction in head-withdrawal threshold at 2 h after administration. Moreover, the numbers of MAGL-immunoreactive neurons in the trigeminal subnucleus caudalis (Vc) and upper cervical spinal cord (C1-C2) were significantly greater in ION-injured mice than in sham-operated mice but were reduced after administration of JZL184. The increase in MAGL immunoreactivity suggests that increased 2-AG production is followed by rapid enzymatic degradation of 2-AG. JZL184 inhibited this degradation and thus increased 2-AG concentra- tion in the brain, particularly in the Vc and C1-C2 regions, thus attenuating pain. Our findings suggest that inhibition of 2-AG degradation by MAGL inhibitors is a promising therapeutic option for treatment of orofacial neuropathic pain.

DOI： 10.2334/josnusd.17-0005

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記述言語：英語   出版者・発行元：WILEY  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

The effects on craniofacial growth of two different soft palate repair techniques in two-stage palatoplasty were investigated. This was a retrospective, cross-sectional cohort study of 68 children with non-syndromic, complete unilateral cleft lip and palate. Thirty-four patients were treated with the modified Furlow method (F-group) and the remaining 34 with the Widmaier-Perko method (P-group). Craniofacial growth was assessed by analyzing 12 angular and 12 linear measurements on lateral cephalograms. Composite facial diagrams from the two groups were compared with those of a control non-cleft group. Angular and linear measurements did not differ significantly between the two groups, implying that the craniofacial morphology was not affected by the difference in soft palate repair technique. However, small differences in anterior nasal spine and posterior nasal spine were found in cleft patients compared with controls. These findings suggest that the modified Furlow and Widmaier-Perko methods have a similar impact on craniofacial growth. Considering speech function, the modified Furlow method provides better craniofacial growth and speech function. However, the long-term effects of both methods on craniofacial growth after growth cessation remain to be determined.

DOI： 10.1016/j.ijom.2017.01.009

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

The purpose of this study was to clarify the impact of orthognathic surgery on oral health-related quality of life (OHRQOL) in patients with jaw deformities. The subjects were 65 patients (21 males and 44 females) who underwent orthognathic surgery. The mean age of the patients was 23.6 years. Forty-seven patients had skeletal class III malocclusions, eight patients had skeletal class II, and 10 patients had skeletal class I with facial asymmetry and/or open bite. OHRQOL was assessed using the Japanese version of the Oral Health Impact Profile (OHIP-J54) before and 6 months after surgery. While OHIP-J54 scores in the patients before surgery were significantly higher than those in the control subjects, OHIP-J54 scores after surgery were significantly lower than those before surgery. OHIP-J54 scores in older patients were significantly higher than those in younger patients. In conclusion, most patients with jaw deformities have lower OHRQOL than individuals with normal occlusion, and orthognathic surgery has a positive impact on OHRQOL. The determination of OHRQOL in patients with jaw deformities seems to be very useful for understanding the patients' problems and for assessing the extent of changes in terms of patient well-being.

DOI： 10.1016/j.ijom.2016.07.003

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier Ltd  

Objective To identify the degree of correlation of various parameters using multiple linear regression analysis with soft tissue changes as the response variable. Subjects and methods The subjects comprised 10 skeletal Class III patients who had undergone bilateral sagittal split osteotomy (BSSO). The candidates for the explanatory variables included 10 parameters, such as overjet, overbite, sella–nasion–A point angle (SNA), upper incisor inclination (U1-SN), incisor mandibular plane angle (IMPA), gonial angle, nasolabial angle, menton deviation, soft tissue thickness, and hard tissue changes. These parameters were measured using cephalograms, dental cast models, and a three-dimensional integration model. Finally, 5 parameters were chosen as explanatory variables. A standard regression coefficient (β value) and an adjusted R-square (R*2 value) were used to assess correlations between soft tissue changes and to evaluate the regression equation. Results In the zygomatic arch and maxillary regions, β values for overjet and SNA were particularly positive and high, whereas those for hard tissue changes were negative and low. In the mandibular central regions, β values for hard tissue changes were positive and high. In the other mandibular regions, β values for menton deviation were higher than those for hard tissue changes. The R*2 values in all regions were greater than 0.5. Conclusion Overjet and SNA were more strongly associated with soft tissue changes in the zygomatic arch maxillary regions than hard tissue changes. The extent of mandibular retraction and menton deviation was highly correlated with the mandibular central regions and the other mandibular regions, respectively.

DOI： 10.1016/j.ajoms.2016.05.006

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER  

The act of eating is a source of pleasure for people and is a major factor in maintaining a good quality of life. Several types of products for dysphagia patients are available to decrease aspiration of food that often accompanies daily food intake. The final goal of these products is to improve the ease of forming a food bolus and/or the safety of the swallowing process; however, tastes of products are not a major concern with initiation of swallowing. In the present study, we investigated the effect of bitter taste stimuli (quinine) and the combination of quinine and umami (monosodium glutamate: MSG) applied to the oropharynx on reflex swallows evoked by electrical stimulation to the oropharyngeal mucosa. Each of the distilled water (DW), quinine and quinine-MSG mixture solution (volume of each solutions, 100 A mu l) was applied 1 s prior to electrical stimulation. No swallow was evoked when each of the solutions was applied without electrical stimulation. The application of DW and lower concentration of quinine (&lt; 100 A mu M) did not affect the latency of reflex swallow, but 100 A mu M quinine application increased the latency of the reflex swallow. In addition, application of quinine-MSG mixture solution counteracted the increase in latency induced by quinine application alone. These findings suggest that MSG enhances the initiation of swallowing along with its well-known increase in appetite stimulation. Adding MSG might be effective when creating food to promote swallowing.

DOI： 10.1007/s10266-015-0226-1

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

The aim of this study was to determine the relationships among bone properties, bone metabolic markers, and types of jaw deformity. The subjects were 55 female patients with jaw deformities. Skeletal morphology was examined using lateral cephalograms, and the patients were divided into three groups according to the type of anteroposterior skeletal pattern. Serum osteocalcin, bone alkaline phosphatase, and tartrate-resistant acid phosphatase isoform 5b, as well as deoxypyridinoline in urine, were measured as bone metabolic markers Quantitative ultrasound (QUS) measurements were used to assess bone properties at the calcaneal bone. The bone volume and bone density of the condylar process were measured in 43 patients by computed tomography. There were no significant differences in bone metabolic markers and QUS parameters between the groups, although bone formation and resorption markers tended to be higher in patients with a protrusive mandible. On the other hand, patients with mandibular retrusion had a higher tendency to have small and dense condylar processes. In conclusion, the results suggest that growth depression or a degenerative change in the mandibular condyle is involved in the pathogenesis of mandibular retrusion, although risk factors for progressive condylar resorption were not determined.

DOI： 10.1016/j.ijom.2016.02.003

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY-ELSEVIER  

A woman was referred to the orthodontic clinic for treatment. She was diagnosed with a skeletal Class II malocclusion, a steep mandibular plane, and an anterior open bite. Conventional orthodontic treatment was considered to correct the maxillary protrusion and anterior open bite, but the patient also requested improvement of her facial esthetics. We therefore decided that nonsurgical treatment consisting of 4 premolar extractions combined with temporary anchorage devices was indicated. Satisfactory improvement of the overjet and overbite, and proper functional occlusion were obtained, resulting in a Class I molar relationship. Active treatment was completed in 2 years 10 months, and the result remained stable at 2 years 6 months after debonding.

DOI： 10.1016/j.ajodo.2015.07.043

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY  

Abnormalities of swallowing in patients with mandibular prognathism have not been evaluated quantitatively. The aim of this study was to compare tongue pressure production for bolus transfer between volunteers with normal occlusion and patients with mandibular prognathism. The control group had 10 female volunteers with normal occlusion, and the patient group had 10 women with mandibular prognathism. Tongue pressure was measured by a palatal sensor sheet at five sites on swallowing 4 mL of a tasteless and odourless jelly. Results: The tongue pressure waveform differed between the control and patient groups. The incidence of a double-peak tongue pressure waveform was more frequent in the patient group. In both groups, the exertion of tongue pressure began at the anterior point of the sensor sheet, followed by the peripheral parts. Although the order of expression of tongue pressure was the same for the two groups, maximum tongue pressure at all parts of the sensor sheet was lower in the patient group than in the control group. Furthermore, swallowing time was longer in the patient group than in the control group at the peripheral parts of the palate. These results clearly show the difference in tongue pressure production during swallowing between patients with mandibular prognathism and volunteers with normal occlusion. The current findings suggest that maxillofacial morphology may affect tongue movement during swallowing.

DOI： 10.1111/joor.12379

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掲載種別：研究論文（学術雑誌）  

© 2016 The Authors. Published by Elsevier B.V. Osteoclasts are multinucleated cells with bone resorption activity that is crucial for bone remodeling. RANK-RANKL (receptor activator of nuclear factor κB ligand) signaling has been shown as a main signal pathway for osteoclast differentiation. However, the molecular mechanism and the factors regulating osteoclastogenesis remain to be fully understood. In this study, we performed a chemical genetic screen, and identified a Cdks/GSK-3β (cyclin-dependent kinases/glycogen synthase kinase 3β) inhibitor, kenpaullone, and two Cdks inhibitors, olomoucine and roscovitine, all of which significantly enhance osteoclastogenesis of RAW264.7 cells by upregulating NFATc1 (nuclear factor of activated T cells, cytoplasmic 1) levels. We also determined that the all three compounds increase the number of osteoclast differentiated from murine bone marrow cells. Furthermore, the three inhibitors, especially kenpaullone, promoted maturation of cathepsin K, suggesting that the resorption activity of the resultant osteoclasts is also activated. Our findings indicate that inhibition of GSK-3β and/or Cdks enhance osteoclastogenesis by modulating the RANK-RANKL signaling pathway.

DOI： 10.1016/j.bbrep.2015.12.011

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

The purpose of this study was to determine the effect of orthognathic surgery on psychological status. The subjects were 119 patients (38 males and 81 females, mean age 25.5 +/- 9.4 years) who underwent orthognathic surgery. They were divided into class III (84 patients), class II (20 patients), and class I (15 patients) groups according to the anteroposterior skeletal pattern, and they were also divided into an asymmetry group (51 patients) and a symmetry group (68 patients). We assessed psychological status using the Minnesota Multiphasic Personality Inventory (MMPI) before surgery and at more than 6 months after surgery. The MMPI scores for the depression, hysteria, psychasthenia, and social introversion scales were significantly higher than standard values before surgery, and the hypomania scale significantly lower. The cannot say scale, depression scale, and hysteria scale decreased significantly after surgery. A comparison of MMPI scores among the groups showed the depression scale in the class III group to be higher than those in the class I and II groups; there was no significant difference between the asymmetry and symmetry groups. In conclusion, orthognathic surgery has a positive influence on the psychological status of patients with jaw deformities, especially patients with skeletal class III malocclusion.

DOI： 10.1016/j.ijom.2015.02.003

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

Background/Objectives: The aim of this study was to determine the most desirable force system to achieve molar protraction from an interdental miniscrew minimizing side-effects. Several iterations of force delivery were simulated through variations in the height of a miniscrew, length of a molar extension arm, and incorporation of a lingual force.
Materials/Methods: A three-dimensional mesh model of the right posterior segment of the mandible was developed from cone beam computed tomography data from a patient missing a first molar. Protraction appliances were constructed using computer-aided design software and integrated with finite element software. After mesh generation, a total of 80 loading conditions were simulated by altering the extension arm length (2-10 mm), miniscrew height (0-8 mm), and magnitude of protraction force from the lingual side (0-1.5 N). A constant labial force of 1 N was used in all models.
Results: As the length of the extension arm increased, mesial tipping decreased, rotation decreased, and buccolingual inclination remained the same without lingual traction force. Lingual traction reduced rotation but increased tipping. Similar trends were observed in all situations despite of the height of the miniscrew.
Conclusions: The height of the miniscrew is not as critical in affecting tooth movement during mandibular second molar protraction as the length of the extension arm. The most ideal force system in the model appeared to be the longest extension arm (10 mm) with the addition of a lingual force of half or equal magnitude of the labial force.

DOI： 10.1093/ejo/cju017

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記述言語：日本語   出版者・発行元：一般社団法人 日本口蓋裂学会  

A seminar on the assessment of cleft palate speech hosted by the Japancleft Committee, Japanese Cleft Palate Association, was held at the University Hospital and the Sanjo Conference Hall, the University of Tokyo on January 31 and February 1, 2015. The purpose of the seminar was to increase awareness of the issues on standardized speech assessment among Japanese speech and language therapists and researchers in the field, and to propose a standardized system which is compatible with international approaches. A training protocol for valid and reliable assessment is to be developed, taking lessons from experiences in the UK and Ireland. Dr. Debbie Sell and Dr. Triona Sweeney, who developed the Cleft Audit Protocol for Speech-Augmented (CAPS-A) and a training package, were invited as lecturers at the seminar. The number of participants was 134, including 67 speech therapists, 57 dentists, and 10 plastic surgeons.&lt;br&gt;The questionnaire survey at the end of the seminar revealed that the importance of developing a standardized assessment system in Japan was fully recognized. From now on, efforts to develop a standardized assessment system will be continued by the working group in the Japancleft Committee.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

This study aimed to examine the contributions of brain-derived neurotrophic factor (BDNF) at the injury site toward neuroma formation and nerve regeneration after inferior alveolar nerve transection. Histological analysis confirmed neuroma formation at 2 weeks after complete transection of the inferior alveolar nerve. A local administration of an antibody to BDNF inhibited connective tissue proliferation at the injury site and promoted nerve fiber integrity. Fluorogold labeling showed a significantly higher number of labeled cells in the trigeminal ganglion in the anti-BDNFtreated group compared with the vehicle control group. In-situ hybridization histochemistry showed intense signals for tropomyosin receptor kinase B mRNA in the area of the injury site containing fibrous or granular tissue in the anti-BDNF-treated group. In contrast, these signals were close to the detection limit in the area of the perineurium in intact nerve trunks, indicating that the signals were expressed by fibroblasts within the connective tissue. These findings suggest that antagonization of endogenous BDNF induced by nerve injury reduces neuroma formation, without inhibiting damaged axon regeneration. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

DOI： 10.1097/WNR.0000000000000231

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY-ELSEVIER  

A Japanese woman, age 29 years 8 months, had a missing mandibular left first molar, bimaxillary dentoalveolar protrusion, and crowding. She had a skeletal Class II relationship and a long face with a steep mandible. She had previously undergone root canal treatment for the mandibular right second premolar, and the mandibular left third molar was impacted. The maxillary left first premolar was extracted for autotransplantation to the mandibular left first molar region. After confirmation of a favorable prognosis for the transplanted tooth, the maxillary right first premolar, the mandibular right second premolar, and the impacted mandibular left third molar were extracted for orthodontic treatment. The active orthodontic treatment period was 32 months. The patient returned for follow-up records 12 years 7 months after the active treatment, and her facial profile and occlusion were well maintained. At 13 years 9 months after transplantation, no abnormalities were observed with the transplanted tooth in the radiographic and clinical evaluations.

DOI： 10.1016/j.ajodo.2013.07.018

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER IRELAND LTD  

To determine the cooperative effect of laryngeal afferent signals on the swallowing reflex, we examined whether afferent signals originating from the left and right superior laryngeal nerve (SLN) modulates elicitation of the swallowing reflex in urethane-anesthetized rats. Mylohyoid electromyographic activity was recorded to quantify the swallowing reflex. The onset latency of the swallowing reflex and the time intervals between successive swallows were used to quantify and compare the effects of unilateral and bilateral electrical stimulations of the SLN. The mean latency of the first swallow and the mean time interval between swallows evoked with low frequency stimulation were both significantly different between unilateral and bilateral stimulations of the SLN. These findings suggest that facilitatory effect of afferent signals originating from the SLN bilaterally increase the motoneuronal activity in the medullary swallowing center and enhance the swallowing reflex. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.neulet.2014.01.017

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective: To assess the postoperative speech and pharyngeal space changes after surgical maxillary advancement, we sought to objectively evaluate these parameters in patients with velopharyngeal insufficiency following palatoplasty due to cleft palate. Subjects and methods: The subjects were 10 cleft palate patients (Group C: 4 males and 6 females, with a mean age of 18 years and 1 month at the time of operation) who had undergone Le-Fort I osteotomies with a mean maxillary advancement of 3.85. mm (range 3.0-5.0. mm). A nasometer test was performed using a nasometer. Articulation during speech was evaluated by a speech therapist. These evaluations were performed immediately before surgery and several weeks, 3 months, and 6 months after the surgery, respectively. Lateral cephalograms of the skull were used for morphological evaluation at 3 months before the surgery and at several weeks and 6 months after the surgery. We examined several parameters using the cephalograms. These data were compared with those of 10 patients without cleft palate who had undergone surgical maxillary advancement for jaw deformities. Results: The nasalance scores (p= 0.001) and the lengths of the soft palate (p&lt
. 0.0001) before surgery differed significantly between the two groups. The nasalance score in Group C was found to temporarily worsen after the surgery, but recovered within 6 months. Abnormal articulations were detected in two Group C patients, but this similarly recovered within 6 months. Discussion and conclusions: Surgical maxillary advancement may be a useful strategy for patients with velopharyngeal insufficiency following palatoplasty due to cleft palate. © 2013 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI.

DOI： 10.1016/j.ajoms.2013.07.006

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Purpose: To investigate the relationship between the severity of occlusal irregularities and orthodontic treatment concern among the population of a developing country using DAI score and to compare with the relationship found in a developed country. Materials and methods: The sample comprised 400 randomly selected university students of Bangladesh, a developing country, 210 males and 190 females, aged 20-27 years. A pretested questionnaire was used to assess the subjects' satisfaction with own dental appearance and orthodontic treatment concern
the actual severity of malocclusion was determined using the Dental Aesthetic Index (DAI). Statistical analysis was carried out using t-test for gender differences
Spearman rank-order correlation coefficients, Scheffe's post hoc test, one way ANOVA and logistic regression analysis were done for correlation between malocclusion severity and response to questionnaire. The data from a similar study that was carried out on the university students of Japan, a developed country, was compared. Result: In Bangladeshi sample, males were more affected by malocclusion. Moderate correlation was found between malocclusion, self-satisfaction and treatment concern where satisfaction was decreased and treatment desire was increased with the severity of malocclusion. In Japanese sample, the prevalence of malocclusion was found more in females. Self-satisfaction and malocclusion showed weak correlation and no significant correlation was found between treatment concern and malocclusion. Conclusion: Although DAI can be used universally to evaluate malocclusion and self-perception, it should be used carefully to determine the subjects' actual desire for orthodontic treatment where the socio-economic condition can be a provocative factor. © 2013 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2013.05.003

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objectives: The purpose of this study was to determine the incidence of temporomandibular joint (TMJ) signs and symptoms in patients with dentofacial deformities and to assess longitudinally the changes in TMJ signs and symptoms after surgical orthodontic treatment. Materials and methods: The subjects consisted of 170 patients with dentofacial deformities. A combination of Le Fort I osteotomy and bilateral sagittal split osteotomies was used in 112 patients, bilateral sagittal split osteotomies were performed in 58 patients. The joints were examined clinically and by computed tomography. Results: TMJ signs and symptoms were recognized in 29.5% of the patients, and disk displacements and condylar bone changes were recognized in 22.1% and 13.4% of the joints, respectively. More patients with mandibular retrusion and asymmetry had TMJ signs and symptoms, disk displacements and condylar bone changes than those with mandibular prognathism. The incidence of TMJ signs and symptoms had significantly decreased to 12.1% at one year after orthognathic surgery, and there were no significant differences in the incidences of TMJ signs and symptoms among the types of dentofacial deformity. Conclusion: Surgical orthodontic treatment has a beneficial effect on TMJ signs and symptoms in most patients with dentofacial deformities. However, there is a risk of TMJ symptoms and signs developing in preoperative asymptomatic patients after orthognathic surgery though the risk is low. © 2012 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI.

DOI： 10.1016/j.ajoms.2012.05.014

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

This study investigated short- and long-term postoperative skeletal changes following intraoral vertical ramus osteotomy (IVRO) for mandibular prognathism, as determined from lateral cephalograms. The subjects were 20 patients with mandibular prognathism who had undergone surgical orthodontic treatment combined with IVRO. Lateral cephalograms were taken at six time points: 1 month before surgery, and 1 day, 3 months, 6 months, 1 year, and approximately 2 years after surgery. Intermaxillary fixation (IMF) with four monocortical screws was maintained for 1 week in all patients. Mean posterior movement of the menton (Me) was 5.9 mm at surgery. 3 months after surgery, the FMA and FH-CorMe angles had increased 6.3 and 6.2 degrees, respectively, indicating clockwise rotation of the distal segment of the mandible. This rotation was observed in all 20 patients, suggesting that postoperative rotation of the mandible in the postoperative short term is likely to occur after IVRO and could be considered an adaptation of the mastication system newly established by surgery. In the long term after IVRO, Me had moved anteriorly by only 0.9 mm. and the relapse ratio was 15.3%. These findings suggest the excellent long-term stability of surgical orthodontic treatment combined with IVRO in patients with mandibular prognathism.

DOI： 10.1016/j.ijom.2012.06.024

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DOI： 10.4103/2278-0203.110327

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER  

We designed an electrical stimulation system to safely and reliably evoke the swallowing reflex in awake humans, and then examined the neural control of reflex swallowing initiated by oropharyngeal stimulation. A custom-made electrode connected to a flexible stainless-steel coil spring tube was introduced into the pharyngeal region through the nasal cavity and placed against the posterior wall of the oropharynx. Surface electrodes placed over the suprahyoid muscles recorded the electromyogram during swallowing. Swallowing reflexes were induced several times by 30 s of repetitive electrical pulse stimulation (intensity: 0.2-1.2 mA, frequency: 10-70 Hz, pulse duration: 1.0 ms). The onset latency of the swallowing reflex was measured over the 10-70 Hz frequency range. In addition, the two time intervals between the first three swallows were measured. The onset latency of the swallowing reflex became shorter as the stimulus frequency increased up to a parts per thousand currency sign30 Hz. Once the frequency exceeded 30 Hz, there was no further reduction in the latency. This finding was consistent with those of previous studies in anesthetized animals. The time intervals between successive swallowing reflexes did not change with increased stimulus frequencies. Furthermore, prolonged stimulation often failed to elicit multiple swallowing reflexes. The frequency dependence of onset latency suggests that temporal summation of pharyngeal afferents is required to activate the medullary swallowing center. This reliable stimulation method may help in rehabilitation of dysphagic patients without causing aspiration.

DOI： 10.1007/s00455-012-9393-1

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記述言語：日本語   出版者・発行元：クインテッセンス出版  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

An adult female patient presented with open bite at Orthodontic Clinic, Niigata University Medical and Dental Hospital. The patient was diagnosed as skeletal Class II open bite with Class III molar relationship, because of temporomandibular joint-osteoarthrosis (TMJ-OA) and the congenital absence of the mandibular lateral incisors. To correct anterior open bite, surgical orthodontic treatment was considered, but post treatment stability was unpredictable and doubtful due to condylar erosion on the CT. We therefore determined that nonsurgical treatment with maxillary first premolars extraction and plate type temporary anchorage device (TAD) placement bilaterally for intruding the maxillary molars would be indicated. At the completion of the active treatment, ideal occlusion was achieved without further resorption of the condyles. Even two years after the treatment, the stable occlusion has been maintained. In conclusion, the orthodontic treatment with TAD is one of the potent devices to provide the ideal occlusion for the patient with TMJ-OA. © 2012 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2012.04.002

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BIOMEDICAL RESEARCH PRESS LTD  

This study examined the immunoexpression pattern of aquaporin-1 (AQP1), first identified as a water channel protein, in the periodontal ligament of rat molars during experimental tooth movement to clarify its role in periodontal responses in an overloaded model by the insertion of a piece of elastic band. In the control group without any treatment, the cementoblasts and osteogenic cells as well as the vascular endothelial cells showed AQP1 immunoreaction. In the experimental group, hyalinized tissue and intensely AQP1 positive amorphous structures which were identified as degenerated endothelial cells by immunoelectron microscopy, occurred at the compression side on Days 1 and 3. AQP1 immunoreaction came to be stronger in the intact endothelial cells around the hyalinized tissue. The hyalinized tissue had almost disappeared by Day 5 when many macrophages reactive to acid phosphatase activity appeared. The periodontal width on Day 7 became almost the same as that in the control group. These findings indicate that the hyalinized tissue and damaged AQP1 positive endothelial cells are phagocytized by macrophages which have temporally migrated, and suggest that the surviving endothelial cells with intense AQP1 reaction are involved in periodontal regeneration by capillary sprouting.

DOI： 10.2220/biomedres.33.225

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DOI： 10.4103/2278-0203.103865

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DOI： 10.4103/2278-0203.99760

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

Progressive condylar resorption is an irreversible complication and a factor in the development of late skeletal relapse after orthognathic surgery. We have evaluated cephalometric characteristics, signs and symptoms in the temporomandibular joint (TMJ), and surgical factors in six patients (one man and five women) who developed it after orthognathic surgery. The findings in preoperative cephalograms indicated that the patients had clockwise rotation of the mandible and retrognathism because of a small SNB angle, a wide mandibular plane angle, and a "minus" value for inclination of the ratrius. There were erosions or deformities of the condyles, or both, on three-dimensional computed tomography (CT) taken before treatment. The mean (SD) anterior movement of the mandible at operation was 12.1 (3.9) mm and the mean relapse was -6.4 (2.5) mm. The mean change in posterior facial height was 4.5 (2.1) mm at operation and the mean relapse was -5.3 (1.8) mm. Two patients had click, or pain, or both, preoperatively. The click disappeared in one patient postoperatively, but one of the patients who had been symptom-free developed crepitus postoperatively. In the classified resorption pattern, posterior superior bone loss was seen in three cases, anterior superior bone loss in two, and superior bone loss in one. Progressive condylar resorption after orthognathic surgery is multifactorial, and some of the risk factors are inter-related. Patients with clockwise rotation of the mandible and retrognathism in preoperative cephalograms; erosion, or deformity of the condyle, or both, on preoperative CT; and wide mandibular advancement and counterclockwise rotation of the mandibular proximal segment at operation, seemed to be at risk. The mandible should therefore be advanced only when the condyles are stable on radiographs, and careful attention should be paid to postoperative mechanical loading on the TMJ in high-risk patients. (C) 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.bjoms.2011.02.006

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

An adult male patient was present with anterior cross bite. He was referred to Orthodontic Clinic of Niigata University Medical and Dental Hospital for recommendation of surgical orthodontic treatment by general practitioner. The patient was diagnosed as skeletal Class III with anterior crowding and missing four premolars. To correct anterior cross bite and crowding, surgical orthodontic treatment was considered, but the patient refused orthognathic surgery. We therefore determined that nonsurgical treatment with mandibular bilateral first molar extraction would be indicated. After treatment, suitable overjet, overbite and proper functional occlusion were attained with Class I molar relation. Active treatment was 34 months, and the treatment result remained stable 2 years and 4 months after debonding. © 2011 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2011.09.005

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective: This study was designed to elucidate the changes in the occlusal condition over a long period of time post-retention in Japanese patients who had undergone extraction treatment with the standard edgewise system (SES), a method of treatment in which the intercanine width and intermolar width are kept unchanged in pre- and post-treatment. Materials and methods: 21 patients were selected from the records of Niigata University Medical and Dental Hospital. These patients had undergone extraction treatment with SES, and their retainers were removed 5 or more years before. The study models were assessed pre-treatment (T1), post-treatment (T2), post-retention (T3), and more than 5. years post-retention (T4) to investigate overjet, overbite, intercanine and intermolar widths, total arch depth and the Irregularity Index (I.I.). Results and discussion: The number of subjects in this study was larger than that in other long-term progress reports on Japanese patients post-retention. The interval between T3 and T4 was on average 8. years and 2 months. Both the mandibular I.I. and the maxillary I.I. became minimum values, suggesting that all the cases had been stable for a long period time post-retention.There were no significant changes in the intercanine width between T1 and T2, which means that the treatment had been performed based on a concept of minimizing any potential changes in intercanine width. Conclusion: The treatment procedure of minimizing potential changes in intercanine width and aligning the teeth in consideration of individual alveolar morphology would contribute to long-term stability of occlusion after retention. © 2011 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2011.02.004

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER IRELAND LTD  

The acid-sensing ion channel 3 (ASIC3), a member of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily, has been reported to participate in acid sensing, mechanosensation, and nociception. However, no information is available regarding the precise localization and function of this molecule in the periodontal ligament, which contains abundant sensory nerves originating from the trigeminal ganglion. The present study examined the expression of ASIC3 in the lingual periodontal ligament of mouse incisors by immunohistochemistry. Furthermore, the expression of ASIC3 in the trigeminal ganglion which innervates the periodontal ligament - was investigated at protein (immunohistochemistry and quantitative analysis) and mRNA levels (RT-PCR technique and in situ hybridization histochemistry). Immunohistochemistry for ASIC3 was able to demonstrate dendritic profiles of the periodontal Ruffini endings in the mouse incisors. No thin fibers terminating as nociceptive free nerve endings exhibited ASIC3 immunoreactivity. Double immunofluorescent staining revealed ASIC3 immunoreaction in the axoplasm but not in the ordinary Schwann cells - including the associated terminal Schwann cells. Observation of the trigeminal ganglia showed variously sized neurons expressing ASIC3 immunoreaction; the most intense immunopositivity was found in the small and medium-sized neurons, as confirmed by in situ hybridization histochemistry using a specific cRNA probe. Quantitative analysis on trigeminal ganglion neurons showed that 38.0% of ASIC3 neurons could be categorized as medium-sized neurons which mediate mechanotransduction. These findings suggest that ASIC3 functions as a molecule for mechanosensation in the periodontal Ruffini endings. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.neulet.2010.11.023

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY-ELSEVIER  

Introduction: The objective of this investigation was to examine the factors influencing the long-term prognosis of autotransplanted teeth with complete root formation. Methods: Thirty-eight teeth, autotransplanted in 32 patients, were examined more than 6 years after transplantation. Periodontal health, condition of restoration, mobility, occlusal contact, level of gingival margin, and course of orthodontic movement were investigated clinically and with radiographs. Results: More than 6 years after autotransplanation, 33 teeth survived in 27 patients. The survival rate was 86.8% (mean observation time, 9.2 years). Abnormal findings were observed in 9 teeth, so the success rate was 63.1%. An inadequate root filling tended to give rise to abnormal findings. Conclusions: The success of autotransplantation of a tooth with complete root formation is affected by the quality of root filling. When possible, clinicians should consider autotransplantation before root formation is complete. (Am J Orthod Dentofacial Orthop 2010;138:720-6)

DOI： 10.1016/j.ajodo.2009.03.043

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：新潟歯学会  

Objective: The purpose of this study was to compare the effect of early and late bone grafts in patients with Cleftlip and alveolus only, consequently excluding the influence of palatal closure on craniofacial growth. Subjects and Methods: The subjects were chosen from the records of the Orthodontic Clinic, Niigata University Medical and Dental Hospital. 30 patients with unilateral cleft lip and alveolus only (without cleft palate) were chosen and divided into 2 groups based on the following selection criteria: Early bone grafting (EBG) at a mean age of 8 years and 3 months. Late bone grafting (LBG) at a mean age of 13 years and 7 months. The majority had orthodontic treatment during the mixed dentition. Lateral cephalograms were traced, and then 22 angular and 27linear measurements were analyzed. Results: Mann-Whitney test showed that all angular measurements were not significantly different between the 8and the 14 years old subjects in the EBG and LBG groups. The difference in the value of A'-PNS between 14 and 8 years showed a significant difference when the groups were compared. Conclusion: The present study showed decrease in anteroposterior maxillary growth in the EBG group. Apossible reason for our finding might be the inhibition of maxillary growth that caused bone grafting operation and the short evaluation period (around 1 year) in the LBG group, while it was longer for the EBG group. Grafted bone is possibly allowed to undergo resorption during remodeling or displacement of the new bone with longer time. As a result, the decrease in the maxillary anteroposterior length exhibited by the distance from A'- PNS was recognized in the EBG group.目的：本研究の目的は片側性唇顎裂患者において二次的顎裂部骨移植の時期の違いが顎顔面形態に及ぼす影響を明らかにすることである。対象：新潟大学医歯学病院矯正歯科診療室において管理されている片側性唇顎裂患者のうち，早期二次的顎裂部骨移植を施行した17 名（骨移植施行平均年齢８歳３か月，以下早期群と略す），晩期二次的骨移植群骨移植を施行した13 名（平均年齢13 歳７か月，以下晩期群と略す）の計30 名を対象とした。これらの８歳時ならびに14 歳時の側面頭部X 線規格写真をトレースし，22 項目の角度計測ならびに27 項目の距離計測を行ない，両群の８歳時ならびに14 歳時の値，および８歳時から14 歳時の変化について両群間で比較した。結果：８歳時ならびに14 歳時両時期において，角度計測項目ならびに距離計測項目のすべての計測項目について両群間で有意差は認められなかった。しかしながら，８歳から14 歳の変化量に関し距離計測項目のうちA'-PNS において，両群間で有意差を認めた。結論：本研究では上顎骨の前後的な長さに関してその変化量に差を認めた。その理由として１．骨移植術施行時の外科的侵襲による成長抑制，２．晩期群では骨移植後移植骨の置換が完了せず，移植骨の吸収も少ない反面，早期群では骨移植後５年前後経過しており移植骨の置換がおこなわれ，A 点付近の骨吸収が生じること，から，上顎骨の前後的な長さに差が生じたと考えられた。

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その他リンク： http://search.jamas.or.jp/link/ui/2010288422

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The aim of this study was to comparatively evaluate the air powder polishing (APP) system with crystalline cellulose with the rubber cup and pumice (RCP) method as prophylactic methods in orthodontic patients. This study included two examinations. First, 58 orthodontic patients were randomized into the APP group or RCP group, and the changes in the colony counts of salivary mutans streptococci (MS) assessed before and after the prophylactic treatment were evaluated. Assessment of MS was conducted three times: immediately before the treatment (Test 1), immediately after the treatment (Test 2), and 1 month after the treatment (Test 3). The samples were inoculated on modified Mitis-Salivarius-Bactracin (MSB) agar plates. Under the microscope, the colonies were counted. In the second experiment, using a randomized split-mouth design, half the mouths of 8 patients were treated with APP and the contralateral side with RCP by three dentists, and then the time required for plaque removal was compared. Significant reduction in the colony count of MS in the saliva was observed in both the APP and RCP groups. However, the count of MS returned to the baseline level after 1 month in both groups. APP removed dental plaques in less time than RCP. APP with crystalline cellulose is a clinically available prophylaxis method for orthodontic patients, and appears to succeed in removing the plaque more quickly. © 2010.

DOI： 10.1016/j.odw.2009.12.015

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記述言語：日本語   出版者・発行元：Japanese Cleft Palate Association  

The Goslon Yardstick Japan Seminar, a training course for the evaluation of dental arch relationships in patients with unilateral cleft lip and palate was held in April 28th-30th, 2009 in Tokyo. In this course, Dr. Michael Mars was invited as a lecturer from the Great Ormond Street Hospital in London, UK. The number of delegates was more than one hundred from a wide variety of specialist. As this was a training course, it was considered that there were large biases in the selection of models evaluated. The result showed that the dental arch relationships in Japanese patients were not so good in total. However, better results were found in some hospitals. We hope that this seminar would contribute to the improvement of the treatments for patients with cleft lip and palate.

DOI： 10.11224/cleftpalate.35.76

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OXFORD UNIV PRESS  

Anterior coronoid marginal depth correlated negatively (r = 0.71) with gonial angle, SNA, and overjet. The coronoid angle also correlated negatively (r = 0.86) with both the vertical and horizontal lengths from sella to the coronoid tip as well as with the horizontal length from sella to the posterior ramus margin. Furthermore, the coronoid length correlated positively (r = 0.61) with the coronoid angle and the anterior coronoid marginal depth. The coronoid width was also positively (r = 0.69) correlated with overbite.
Coronoid process morphology is related not only to mandibular morphology and position but also to maxillary position and the dental relationship in the anterior region. It therefore seems clear that coronoid process morphology might be related to temporal muscle functioning and its associated craniofacial morphological measurements.

DOI： 10.1093/ejo/cjp043

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHROMA INC  

The present study was undertaken to investigate the correlation between condylar position, articular eminence morphology, and mandibular deviation using helical CT in a group of 22 female subjects (mean age 19.2 +/- 5.3 years) with mandibular deviation. There was a significant difference in the angles of the posterior-slope of the articular eminence (PSA) between the deviated (44.27 +/- 10.29 degrees) and non-deviated (42.50 +/- 9.90 degrees) sides. Mandibular deviation also correlated significantly with both medial joint space (r=0.581) and the PSA (r=0.653). A significant negative correlation was also found between mandibular deviation and the anterior/posterior joint space ratio (r=-0.450). These results demonstrated that patients with mandibular deviation possibly show asymmetries not only in their glenoid fossa morphology but also in their condylar position.

DOI： 10.1179/crn.2009.037

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY  

The terminal Schwann cells (TSCs) which play crucial roles in regeneration of the periodontal Ruffini endings (RE) exhibit immunoreaction for glial cell line-derived neurotrophic factor (GDNF). However, no information is available regarding the role of GDNF in the periodontal RE during nerve regeneration. This study was undertaken to examine the changes in GDNF expression in the rat periodontal RE following transection of the inferior alveolar nerve (IAN) using immunohistochemistry for GDNF and S-100 protein, a marker for the TSCs. We additionally investigated the changes in expression of GDNF in the trigeminal ganglion (TG) at protein and mRNA levels. A transection to IAN induced a disappearance of the TSCs from the alveolus-related part (ARP), followed by a migration of spindle-shaped cells with S-100 but without GDNF immunoreactions into the tooth-related part (TRP) by postoperative (PO) week 2. At PO week 2, GDNF immunoreacted cellular elements increased in number in the ARP although the spindle-shaped cells without GDNF reaction remained in the TRP After PO week 4, many GDNF-positive TSCs appeared in the ARP though the spindle-shaped cells vanished from the TRP. A real time RT-PCR analysis demonstrated the highest elevation of GDNT mRNA in the TG at PO week 2. These findings suggested the involvement of this molecule in the maturation and maintenance of the periodontal RE during regeneration. Taken together with our previous and current studies, it appears that the regeneration of the periodontal RE is controlled by multiple neurotrophins in a stage-specific manner. Anat Rec, 292:1182-1191, 2009. (C) 2009 Wiley-Liss, Inc.

DOI： 10.1002/ar.20931

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：MEDIMOND S R L  

Inter-center collaboration in Japan has been growing rapidly in recent years. A six-center collaborative study on the outcomes of primary surgeries in patients with unilateral cleft lip and palate was performed in 2002-2005 (Japancleft Study). After this study, the number of participants in this collaborative study group has increased to more than 20 and a survey on the orthodontic treatment was performed. Opinions of the orthodontic patients after treatment were also collected. The Japanese Cleft Palate Association (JCPA) conducted a nation wide survey on 4349 patients with cleft lip and/or plate about the primary care. JCPA also performed a survey on the current team care in Japan. Large number of hospitals and small number of patients in many hospitals seems to be the problem in Japan.

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記述言語：日本語   出版者・発行元：一般社団法人 日本心身医学会  

DOI： 10.15064/jjpm.49.6_684_2

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記述言語：日本語   出版者・発行元：一般社団法人 日本心身医学会  

DOI： 10.15064/jjpm.49.6_544_2

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記述言語：日本語   出版者・発行元：一般社団法人 日本心身医学会  

身体疾患患者は,健常者に比し気分障害を高率に併存する.一般診療科を受診する気分障害患者は,身体症状を訴えるが,精神症状については訴えることが少ないことから,診断が困難な場合がある.さらに基礎疾患の症状とうつ症状が類似していることも多く,ていねいな医療面接を行い注意深く観察することが必要である.また気分障害を併存する場合,基礎疾患に伴う症状以外に多くの症状を有する.基礎疾患と乖離する身体症状を認めた場合には,他の疾患の合併を疑い検索すると同時に,うつ症状を適切に認知し慎重に判断する必要がある.基礎疾患の示す検査所見とうつ症状の程度が関連することもあり,身体管理には検査成績の変化とともにうつ症状についても注意を要する.適切な身体医学的な治療にもかかわらず,改善の乏しい場合,治療困難を感ずる場合,またQOL障害の低下が予想以上である場合には気分障害の併存について検討を要し,状況の応じて専門医と連携を図り,包括的診療を行う.

DOI： 10.15064/jjpm.49.9_971

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その他リンク： http://search.jamas.or.jp/link/ui/2009333478

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

The aims of this study into bimaxillary surgery were to investigate and compare the postoperative stability of deviated side (lengthened side) and non-deviated side (shortened side), the effect of the type Of Surgery performed in the mandible, and the changes in signs and symptoms of temporomandibular joint (TMJ) disorders before and after Surgery. The sample consisted of 31 Class III patients in whom imbalance between the maxilla and the mandible were corrected by Le Fort I osteotomy combined with bilateral intraoral vertical ramus osteotomy, (BIVRO group, n = 9), bilateral sagittal split ramus osteotomy (BSSRO group, it = 10), or IVRO and SSRO (IVRO + SSRO group, n = 12). IVRO+SSRO and BIVRO are more effective in improving TMJ signs and symptoms. There was no significant post-surgical difference between deviated and non-deviated sides in any group. BIVRO and BSSRO showed excellent post-surgical stability on both sides, less was found in the IVRO + SSRO group. The IVRO + SSRO group showed greater transverse displacement in menton point than the BIVRO group. In conclusion, after bimaxillary Surgery and in asymmetric patients there were no differences between deviated and non-deviated sides, BIVRO and BSSRO appear to be more stable than IVRO + SSRO.

DOI： 10.1016/j.ijom.2008.05.018

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The purpose of this study was to investigate the association of frontal and lateral craniofacial morphology with the inclination of the articular eminence and TMJ pathology, in orthodontic patients with TMJ disorders and unilateral condylar bone change, using helical CT scans. Fifty-nine female patients were divided into a unilateral condylar bone change (UBC) group (39 subjects) and a no condylar bone change (NBC) group (20 subjects). Lateral and frontal cephalograms and panoramic radiographs were taken to evaluate their craniofacial morphology, and condylar and ramal heights. All subjects had CT scans taken to evaluate their TMJs. The inclination angle of the posterior slope of the articular eminence was then measured using National Institute of Health software. CT and cephalometric measurements showed that articular eminence inclination was significantly smaller on the affected side than on the non-affected side (p &lt
0.0001), and that the mandible deviated to the ipsilateral side in UBC, with decreased condylar height and more inclined frontal maxillary, interocclusal and gonial planes (p &lt
0.0001). The difference in articular eminence inclination was correlated significantly with UBC (p &lt
0.05). These results suggested that asymmetrical frontal craniofacial morphology could be clinical indicators of unilateral condylar bone change and remodeling of the articular eminence. © 2008 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2008.04.001

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

Objective: The aim of this study was to investigate the relapse tendency in the maxillary dental arch widths in unilateral cleft lip and palate patients with different types of maxillary arch form.
Subjects: Thirty-two unilateral cleft lip and palate patients treated by one-stage surgical palatal closure were included. The subjects were divided into three groups according to the types of the maxillary arch forms: group A, symmetrical arch form; group 13, collapse of minor segment; group C, collapse of both segments.
Methods: Using dental casts obtained at three different times, relapse in the intercanine, interpremolar, and intermolar widths in each group was assessed and differences between groups were investigated.
Results: Patients in group A showed stable results in all measurements. Patients in group B showed posttreatment relapse in the intercanine width only, whereas patients in group C demonstrated significant posttreatment relapses in the interpremolar and intermolar widths. Comparison between groups showed more significant relapse in the interpremolar and intermolar widths of group C than in those of group B.
Conclusion: The types of the maxillary arch forms in unilateral cleft lip and palate patients might play a stronger role in the stability of the maxillary dental arch widths after orthodontic treatment in patients with collapse of both segments and a severe degree of maxillary narrowness.

DOI： 10.1597/07-053.1

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

Objective: The aim of this study was to investigate the relapse tendency in the maxillary dental arch widths in unilateral cleft lip and palate patients with different types of maxillary arch form.
Subjects: Thirty-two unilateral cleft lip and palate patients treated by one-stage surgical palatal closure were included. The subjects were divided into three groups according to the types of the maxillary arch forms: group A, symmetrical arch form; group 13, collapse of minor segment; group C, collapse of both segments.
Methods: Using dental casts obtained at three different times, relapse in the intercanine, interpremolar, and intermolar widths in each group was assessed and differences between groups were investigated.
Results: Patients in group A showed stable results in all measurements. Patients in group B showed posttreatment relapse in the intercanine width only, whereas patients in group C demonstrated significant posttreatment relapses in the interpremolar and intermolar widths. Comparison between groups showed more significant relapse in the interpremolar and intermolar widths of group C than in those of group B.
Conclusion: The types of the maxillary arch forms in unilateral cleft lip and palate patients might play a stronger role in the stability of the maxillary dental arch widths after orthodontic treatment in patients with collapse of both segments and a severe degree of maxillary narrowness.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL PUBLISHING, INC  

Inequalities within dentistry are common and are reflected in wide differences in the levels of oral health and the standard of care available both within and between countries and communities. Furthermore there are patients, particularly those with special treatment needs, who do not have the same access to dental services as the general public. The dental school should aim to recruit students from varied backgrounds into all areas covered by the oral healthcare team and to train students to treat the full spectrum of patients including those with special needs. It is essential, however, that the dental student achieves a high standard of clinical competence and this cannot be gained by treating only those patients with low expectations for care. Balancing these aspects of clinical education is difficult. Research is an important stimulus to better teaching and better clinical care. It is recognized that dental school staff should be active in research, teaching, clinical work and frequently administration. Maintaining a balance between the commitments to clinical care, teaching and research while also taking account of underserved areas in each of these categories is a difficult challenge but one that has to be met to a high degree in a successful, modern dental school.

DOI： 10.1111/j.1600-0579.2007.00497.x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY-ELSEVIER  

Introduction: Evaluations of the dental arch widths and mandibular-maxillary base are needed for a comprehensive dentofacial analysis in subjects with Class III malocclusion. The aim of this study was to analyze the development of the dental arches and the skeletal mandibular-maxillary bases in untreated subjects with Class III malocclusions. Methods: Two groups of subjects, 1 with Class III malocclusion and the other with Class I malocclusion, were examined. Maxillary skeletal base width, biantegonial widths, and maxillary and mandibular intermolar widths were determined on posteroanterior cephalograms at annual intervals between the ages of 10 and 14 years. Results: Maxillary skeletal base widths and intermolar widths in the Class III subjects were significantly smaller than those in the Class I subjects (P &lt;.05). No statistically significant differences were found among the groups for skeletal mandibular width or intermolar width for the total observation period. The deviations in molar differences increased from ages 10 to 14 in the Class III group. Conclusions: The main transverse deficiencies in the Class III group were maxillary deficiencies in both skeletal and dental widths. The deviations in molar differences appear to become larger from age 10 to age 14.

DOI： 10.1016/j.ajodo.2006.01.045

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Scientific Communications International Ltd  

Custom-made artificial bone produced by the figurative lithographic method based on 3-dimensional computed tomography data is now available as a compatible and reliable implant. We describe a patient with hemifacial microsomia who was treated with custom-made artificial bone, made from hydroxyapatite, for facial symmetry. Using the implant was less invasive surgically and shortened the operating time. A full-scale model and template were created using the binder jet method and 3-dimensional computed tomography images reformatted with single-helical scan data. These technologies were useful for producing the custom-made implant and explaining the procedure to the patient perioperatively. A symmetrical profile of the patient's face has been maintained without any resorption of the implant and graft bed for 3 years. The hydroxyapatite custom-made implant was effective for facial rehabilitation in the treatment of mandibular asymmetry due to hemifacial microsomia. © 2008 Asian Association of Oral and Maxillofacial Surgeons.

DOI： 10.1016/S0915-6992(08)80028-3

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記述言語：日本語   出版者・発行元：一般社団法人 日本心身医学会  

DOI： 10.15064/jjpm.48.6_585_1

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY-ELSEVIER  

The main purpose of this study was to develop soft-tissue cephalometric standards for Yemeni men and compare them with the cephalometric standards of normal North American white people.
Methods: Fifty Yemeni men ( ages, 20-27 years; mean, 23.1 years) with normal occlusion were selected. With double selection by orthodontists and laypersons, a subsample of esthetically pleasing subjects was selected. Lateral cephalometric radiographs of all subjects were analyzed according to the Legan-Burstone and the Holdaway analyses.
Results: The Yemeni esthetically pleasing subjects (YPG) and the remaining subjects (YNG) showed significant differences with respect to mandibular prognathism, lower face-throat angle, nasolabial angle, mentolabial sulcus depth, and interlabial gap, when compared with the Legan-Burstone norms for white Americans; the YPG also had significantly less obtuse facial convexity angle than the YNG. Most values of both Yemeni groups were generally within the range of the values reported by Holdaway, except for 3 variables: skeletal profile convexity, basic upper-lip thickness, and H-angle, which were all significantly larger than those of Holdaway; the YPG showed less skeletal profile convexity than the YNG.
Conclusions: These results show that the soft-tissue facial profiles of white Yemenis and Americans are different in certain respects; these racial differences must be considered during diagnosis and treatment planning. These results should serve as a useful reference for orthodontists and maxillofacial surgeons who treat Yemeni patients and also contribute to more satisfactory diagnosis and treatment planning for them.

DOI： 10.1016/j.ajodo.2007.03.018

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The aim of this study was to evaluate the changes of caries risk and oral microbial flora in the patients having edgewise appliance. Forty-two patients treated at the Orthodontic Clinic of Niigata University Hospital participated. Using a caries risk examination kit by Bio Medical Laboratory (BML, Tokyo), stimulated saliva test was performed to investigate the salivary flow rate, pH of saliva, buffer capacity, and the levels of lactobacilli. Modified Mitis-Salivarius-Bacitracin (MSB) agar plates were used to detect and count Streptococcus mutans and S. sobrinus. Furthermore, the members of commensal bacteria and transient bacteria in aerobic culture medium were examined in salivary level to investigate the alterations in oral microbial flora. The number of mutans streptococci and lactobacilli decreased after 1 month of treatment, and then increased to reach the initial level at 3 months. While the amount of plaque increased and saliva pH deteriorated after the onset of treatment, the salivary flow rate improved. The number of transient bacteria showed a tendency toward an increase. These results demonstrate that both caries risk and oral microbial flora balance possibly change with the placement of appliances. Therefore, caries risk test should be performed before and during orthodontic treatment to monitor alterations in intraoral environment of the orthodontic patients not to cause an iatrogenic caries. © 2007 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2007.03.001

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：E H ANGLE EDUCATION RESEARCH FOUNDATION, INC  

Objective: To analyze the sagittal, vertical, and transverse relationships of the maxilla and mandible in Japanese girls with Class III malocclusions with different inclination of mandibular plane.
Materials and Methods: This longitudinal study utilized serial posteroanterior and lateral cephalograms of 56 untreated subjects from the age of 8 years until the age of 14 years (low mandibular plane angle group: n = 20; average mandibular plane angle group: n = 15; high mandibular plane angle group: n = 21). Sagittal and vertical growth was analyzed on the basis of lateral cephalograms, and transverse growth was analyzed on the basis of posteroanterior cephalograms.
Results: There was no significant difference in intermaxillary sagittal relationships among the three groups from age 8 until 14. On the other hand, there were significant changes in the vertical and transverse intermaxillary relationships during this period. When comparing the three groups at the same age, there were significant differences in vertical and transverse intermaxillary relationships in some ages, whereas no significant difference was found in sagittal relationships in any ages.
Conclusions: The inclination of mandibular plane might play a role in anticipating changes in vertical and transverse intermaxillary relationships from 8 until 14 years of age.

DOI： 10.2319/042506-174

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY-ELSEVIER  

Introduction: The purpose of this study was to compare the short-term and long-term effects of bimaxillary surgery with those of mandibular setback surgery concerning pharyngeal airway measurements at 3 levels: nasopharynx, oropharynx, and hypopharynx. Methods: The sample included 66 Japanese women in 2 groups who had been diagnosed with Class III skeletal deformities and had undergone surgical-orthodontic treatment. Those in group A (35 patients) underwent bilateral sagittal split ramus osteotomies; those in group B (31 patients) underwent LeFort I procedures with bilateral sagittal split ramus osteotomies. Lateral cephalograms were assessed within 6 months before surgery and at short-term (3-6 months after surgery) and long-term (at least 2 years after surgery) follow-ups. Results: In group A, the pharyngeal airway was constricted significantly at the oropharyngeal and hypopharyngeal levels at both the short-term and the long-term follow-ups. In group B, significant changes were shown at the 3 pharyngeal levels at the short-term follow-up, whereas no significant changes were shown at the long-term follow-up. Conclusions: These results indicate that, when possible, bimaxillary surgery rather than only mandibular setback surgery is preferable to correct a Class III deformity to prevent narrowing of the pharyngeal airway space, a possible predisposing factor in the development of obstructive sleep apnea.

DOI： 10.1016/j.ajodo.2005.06.028

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-LISS  

Little is known about the role of neurotrophin-4/5 (NT-4/5) in the regeneration of mechano-receptors. Therefore, the present study examined the regeneration process of Ruffini endings in the periodontal ligament in nt-4/5-deficient and wildtype mice following transection of the inferior alveolar nerve by immunohistochemistry for protein gene product 9.5 (PGP 9.5), a general neuronal marker, and by computer-assisted quantitative image analysis. Furthermore, rescue experiments by a continuous administration of recombinant NT-4/5 were performed and analyzed quantitatively. At postoperative day 3 (PO 3d), almost all PGP 9.5-positive neural elements had disappeared; they began to appear in both types of animals at PO 7d. At PO 10d, almost all nerve fibers showed a beaded appearance, with fewer ramifications in both types of mice. Although the regeneration proceeded in the wildtype, a major population of the periodontal Ruffini endings continued to display smooth outlines at PO 28d in the nt-4/5 homozygous mice. The reduction ratio of neural density reached a maximum at PO 3d, decreased at PO 10d, and later showed a plateau. In a rescue experiment, an administration of NT-4/5 showed an acceleration of nerve regeneration in the homozygous mice. These findings indicate that the nt-4/5depletion causes a delay in the regeneration of the periodontal Ruffini endings, but the delay is shortened by an exogenous administration of NT-4/5. Combined with our previous findings of bdnf-deficient mice (Harada et al. [2003] Arch Histol Cytol 66:183-194), these morphological and numerical data suggest that multiple neurotrophins such as NT-4/5 and brain-derived neurotrophic factor (BDNF) play roles in their regeneration in a stage-specific manner.

DOI： 10.1002/cne.21256

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：E H ANGLE EDUCATION RESEARCH FOUNDATION, INC  

Objective: To analyze the development of the dental arches and skeletal mandibular-maxillary bases in untreated Class III malocclusions with low averages and high mandibular plane angles in subjects aged 10 to 14.
Materials and Methods: The records of 50 untreated Japanese girls with Class III malocclusions at age 10 were selected from the files of patients pending orthodontic surgery. The patients included those with low (&lt;= 27 degrees), average (27 degrees through 37 degrees) and high (&gt; 37 degrees) mandibular plane angles. The maxillary skeletal base width, biantegonial width, and maxillary and mandibular intermolar width were determined on posteroanterior cephalograms obtained at annual intervals when subjects were between 10 and 14 years of age. The difference between the maxillary and mandibular intermolar width was also calculated and reported.
Results: All skeletal and dental transverse widths in the high-angle group were significantly smaller than those in the low-angle group (P &lt;.05) from ages 10 to 14. On the other hand, the maxillary to mandibular molar difference was the same for the three groups (P &gt;.05) at each age. The deviations in molar differences did increase from age 10 to age 14 in all three groups.
Conclusion: Mandibular plane angles might play a stronger role in the transverse skeletal growth of the maxilla and the mandible than the transverse dental growth of the maxilla and the mandible.

DOI： 10.2319/011006-15

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   出版者・発行元：一般社団法人 日本心身医学会  

DOI： 10.15064/jjpm.47.12_1047_2

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：E H ANGLE EDUCATION RESEARCH FOUNDATION, INC  

Objective: To analyze the sagittal, vertical, and transverse relationship of the maxilla and mandible in Japanese girls with Class III malocclusions.
Materials and Methods: This longitudinal study utilized biannual posteroanterior and lateral cephalograms of 44 untreated subjects from age 8 to 14 years (Class I, 23 girls; Class III, 21 girls). Sagittal and vertical growths were analyzed on the basis of lateral cephalograms, and transverse growth was analyzed on the basis of posteroanterior cephalograms.
Results: There was no significant difference in sagittal intermaxillary relationships in Class III malocclusion from age 8 to 14 years, whereas significant difference in vertical and transverse intermaxillary relationships appeared with ages during this period. When comparing Class III to Class I malocclusions at the same age point, there were significant differences in sagittal and transverse intermaxillary relationships, whereas significant difference in vertical intermaxillary relationship appeared after 12 years of age.
Conclusion: The results suggest that the sagittal intermaxillary relationships in Class III malocclusions were established before 8 years of age and remained through puberty and that the vertical and transverse intermaxillary relationships in Class III malocclusions changed with ages from 8 to 14 years.

DOI： 10.2319/102005-371

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：E H ANGLE EDUCATION RESEARCH FOUNDATION, INC  

Palatal implants can be used with a transpalatal arch (TPA) connected with the second premolar to provide anchorage. The purpose of this study was to compare the anchorage effects of an osseointegrated palatal implant (OPI) with a nonosseointegrated palatal implant (NOPI), using finite element analysis. One model, which was composed of two maxillary premolars, periodontal ligament (PDL), alveolar bone, a palatal implant, palatal bone, a bracket, band, and TPA, was created on the basis of the clinical situation. The palatal implant was treated as either NOPI or OPI. The force on the premolars was investigated under three conditions: a distomesial horizontal force, a buccolingual horizontal force, and a vertical intrusive force. The PDL stress was calculated and compared with a model without an implant. The result showed that OPI could reduce PDL stress significantly. (The average stress was reduced by 14.44% for the distomesial horizontal force, 60.28% for the buccolingual horizontal force, and 17.31% for the vertical intrusive force.) The NOPI showed almost the same anchorage effect as OPI. The stress on the NOPI surface was higher than that on the OPI surface, but the stress was not high enough to result in failure of the implant. These results suggested that waiting for osseointegration might be unnecessary for an orthodontic implant.

DOI： 10.1043/0003-3219(2006)076[0660:AEOOVN]2.0.CO;2

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

Le Fort Iに口蓋傍正中分割の併用が必要であった上顎歯列弓の狭窄を伴った顎変形症の2例を経験した.上顎歯列弓の狭窄を伴う顎変形症に対してLe Fort Iに口蓋傍正中分割を加えた.大口蓋動静脈の損傷,歯根損傷の危険性が少なく安全かつ容易に上顎歯列弓の拡大が可能であった.側方への拡大量に限界があるが,一期的に歯列弓形態の改善が可能で,矯正治療の補助のひとつとして有用であることが示唆された.施行後の矯正治療において,さらなる上顎歯列弓拡大の可能性が示唆された

DOI： 10.5927/jjjd1991.16.16

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The palatal implant can be used with a transpalatal arch (TPA) connected with the second premolar to provide anchorage. The purpose of this study was to analyze the anchorage effects of a palatal implant by using a finite element analysis. Four models (Model 1 with a 6-mm implant, Model 2 with a 4-mm implant, Model 3 without an implant, Model 4 without TPA or an implant) were created according to the clinical situation. Stress induced in three dimensions (mesial, transversal, and vertical) was investigated. The results showed that a 6-mm palatal implant could reduce periodontal ligament stress significantly (average stress was reduced 14.44% for the mesial force, 17.31% for the vertical force, and 60.28% for the transversal force separately). The 4-mm palatal implant showed almost the same anchorage effect as the 6-mm implant. TPA showed significant anchorage effect (average stress was reduced 8.16%) only when the second premolars were subjected to transversal force. These results suggest that the anchorage effect of palatal implants was related to the direction of the forces and that a 4-mm implant might have the same anchorage effect as a 6-mm implant. © 2006 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2005.11.001

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：INT SOC HISTOLOGY & CYTOLOGY  

Neurotrophin-4/5 (NT-4/5)-a member of the neurotrophic factors-is a ligand for TrkB, which has been reported to be expressed in the mechanoreceptive Ruffini endings of the periodontal ligament. The present study examined developmental changes in the terminal morphology and neural density in homozygous mice with a targeted disruption of the nt-4/5 gene and wild-type mice by immunohistochemistry for protein gene product 9.5 (PGP 9.5), a general neuronal marker, and by quantitative analysis using an image analyzer. Postnatal development of terminal Schwann cells was also investigated by enzymatic histochemistry for non-specific cholinesterase activity (ChE). Furthermore, the immuno-expression of TrkB and low affinity nerve growth factor receptor (p75-NGFR) was surveyed in the periodontal Ruffini endings as well as trigeminal ganglion. At postnatal 1 week, the lingual periodontal ligament of both types of mice contained PGP 9.5-positive nerve fibers showing a tree-like ramification with axonal swellings in their course. In both types of mice at 2 weeks of age, comparatively thick nerve fibers with a smooth outline increased in number, and frequently ramified to form nerve terminals with dendritic profiles. However, no typical Ruffini endings with irregular outlines observed in the adult wild-type mice were found in the periodontal ligament at this stage. At postnatal 3 weeks, typical Ruffini endings with irregular outlines were discernable in the periodontal ligament of the wild-type mice while the dendritic endings showing smooth outlines were restricted to the homozygous mice. After postnatal 8 weeks, both types of mice showed an increase in the number of Ruffini endings, but the morphology differed between the wildtype and NT-4/5 homozygous mice. In the wild-type mice, a major population of the Ruffini endings expanded their axonal branches and developed many microprojections, resulting in a reduction of endings with smooth outlines. In contrast, we failed to find such typical Ruffini endings in the periodontal ligament of the homozygous mice: A majority of the periodontal Ruffini endings continued to show smooth outlines at postnatal 12 weeks. Quantitative analysis on neural density demonstrated a reduction in the homozygous mice with a significant difference by postnatal 8 weeks. Enzymatic histochemistry for non-specific ChE did not exhibit a distinct difference in the distribution and density of terminal Schwann cells between wild-type and homozygous mice. Furthermore, TrkB and p75-NGFR mRNA and proteins did not differ in the trigeminal ganglion between the two types. The periodontal Ruffini endings also displayed immunoreactivities for TrkB and p75-NGFR in both phenotypes. These findings suggest that the nt-4/5 gene depletion caused a delay in the formation and maturation of the periodontal Ruffini endings in the mice by inhibiting the growth of the periodontal nerves at an early stage, and indicate that multiple neurotrophins such as NT-4/5 and BDNF might play roles in the development and/or maturation of the periodontal Ruffini endings.

DOI： 10.1679/aohc.68.267

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：W B SAUNDERS CO  

Purpose: The purpose of this study is to propose a mathematical model to predict the change in pharyngeal airway space (PAS) associated with mandibular setback surgery.
Patients and Methods: Twenty-three female adults, who were diagnosed as having skeletal Class III deformity, underwent mandibular setback surgery by bilateral sagittal split ramus osteotomy (BSSO) and orthodontic multibracket treatment. The subjects were assessed within 6 months before operation (T1) and 1 to 1.5 years after mandibular setback surgery (T2). The PAS change in the level of the base of the tongue was predicted.
Results: The equation is: PAS narrowing = 0.386 - 0.541 ANB (T1 - T2) + 0.253 Co-Gn (T1 - T2) - 0.098 SN-GoGn (T1 - T2), where ANB is the angle formed by the planes nasion-point A and nasion-point B, Co is condylion, Go is gonion, and Gn is gnathion. The PAS change can be predicted by the mandibular changes after setback surgery 66.2% with the regression equation using the change of the ANB angle, the total mandibular length (Co-Gn) and the mandibular plane (SN-GoGn), where SN is sella-nasion.
Conclusions: The equation can be used to predict the change of pharyngeal airway space after mandibular setback surgery. In patients who have other risk factors, such as obesity, short neck, macroglossia, large uvula, and excessive soft tissue around the nasopharyngeal region, a mandibular setback surgery could possibly predispose to the development of sleep apnea syndrome. (c) 2005 American Association of Oral and Maxillofacial Surgeons

DOI： 10.1016/j.joms.2005.06.007

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

主にX線CT三次元再構築画像を用いて,顔面非対称を伴う骨格性下顎前突症患者の顎矯正手術前後における顔面硬組織変化量に対する軟組織変化量(硬組織に対する軟組織の追従率)について,正中付近を含めた,頬部外側縁までの広範囲な領域を測定範囲として分析した.分析のため,領域1(偏位側頬部),領域2(非偏位側頬部),領域3(偏位側オトガイ部),領域4(非偏位側オトガイ部)とした.術前後の変化で後退を示した計測点は,領域1で910点,領域2で114点,領域3で1435点,領域4で417点,突出を示した計測点は,領域1で86点,領域2で401点,領域3で1点,領域4で434点であった.三次元分析は左右差の検出能に優れ,顔面非対称患者の顎矯正手術前後における硬組織変化量に対する軟組織変化量を広範囲かつ客観的に扱えることが示唆された

DOI： 10.5927/jjjd1991.15.87

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：E H ANGLE EDUCATION RESEARCH FOUNDATION, INC  

The purpose of this study was to compare the anchorage effect of the osseointegrated implant with different fixation types using finite element analysis. Three fixation types were investigated. fixation type 1: implant neck in the oral-palatal cortical bone and implant tip in the cancellous bone; fixation type 2: implant neck in the oral-palatal cortical bone and implant tip in the nasal-palatal cortical bone; fixation type 3: implant neck in the oral-palatal cortical bone and implant tip projecting into the nasal cavity. Three finite element models were constructed. Each consisted of two maxillary second premolars, their associated periodontal ligament (PDL), alveolar bones, palatal bone, palatal implant, and a transpalatal arch. Another model without an implant was used to compare with the previous models. The horizontal force (mesial five N, palatal one N) was loaded at the buccal bracket of each second premolar. The stress was calculated in the PDL and implant surrounding bone. The result showed that the palatal implant could significantly reduce von Mises stress (maximum von Mises stress was reduced 30%) and evenly distribute stress in the PDL. The stress magnitude and distribution in the PDL was almost the same in the three implant models. These results suggest that different implant fixation types have almost the same anchorage effects.

DOI： 10.1043/0003-3219(2005)75[593:AEOAPO]2.0.CO;2

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：E H ANGLE EDUCATION RESEARCH FOUNDATION, INC  

This case report describes the effect of a combination of high-pull headgear and Class III elastics on the nonsurgical treatment of an adult open bite. The 19-year 1-irionth-old Japanese female presented with the anterior open bite of 4.0 min and mild crowding. She had a skeletal Class II but a Class III molar relationship due to a severe proclination of the mandibular dental arch. Unilateral congenital missing premolars caused a discrepancy between the facial and dental midline. After extraction of two premolars and the impacted mandibular third molars, nonsurgical therapy was performed using the standard edgewise appliance combined with a high-pull headgear and Class III elastics. The successful treatment outcome and stability of the final occlusion indicates that a combination of high-pull headgear and Class III elastics is one of the effective devices in the nonsurgical treatment of open bite and, is especially helpful in uprighting the mandibular dental arch.

DOI： 10.1043/0003-3219(2005)075<0273:NTOAOB>2.0.CO;2

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   出版者・発行元：新潟大学  

Rehabilitation makeup therapy supports social reintegration by altering self body images, and it is probably a type of cognitive behavior therapy in psychiatric medicine. The aim of this study was to clarify the significance of rehabilitation makeup by examining its psychiatric and psychological effects according to the examination lists created before and after rehabilitation makeup. Subjects consisted of 181 females and 6 males (mean age 34.9 years), who underwent rehabilitation makeup between January 2003 and March 2004, with their permission to participate in this study. Methodology : 32 items of a depression perception scale were used in the examination lists, including 10 items of negative self-perception such as extremely self-humiliating and self-deprecating tendencies, 11 items of interpersonal perception such as excessive sensitivity to others' evaluations and anaclisis, and 11 items of Compulsive thinking such as perfectionism and lack of flexibility. These 3 items and the comprehensive evaluation of each subject were classified into 3 status levels : critical area (-1point), moderately harmful (0 points), and no harm (+1point). A statistical test was Conducted using alterations observed before and after makeup as points (points after makeup-points before makeup). Results and Conclusion : As for the negative self perception, 33 subjects (17.6%) in the critical area before makeup were reduced to 11 (0.59%) after makeup. Similarly, the numbers of subjects in the critical area before makeup were reduced from 40 (21.4%) to 20 (10.7%), 23 (12.3%) to 16 (8.6%), and 25 (13.4%) to 8 (4.3%) after makeup as to interpersonal perception,compulsive thinking, and integrative evaluation, respectively. A statistical test confirmed a significant increase level of less than 5% regarding compulsive thinking, and less than 1% as to negative self perception, interpersonal perception, and the comprehensive evaluation. As to result, it is suggested that rehabilitation makeup has mental and psychological effects on individuals with facial disfigurements.リハビリメイクは、自己のボディイメージを変容、あるいは受容させることによる社会復帰を支援するものであり、精神医学における一種の行動療法･認知療法に通ずると考えられる｡本研究では、リハビリメイク施行前後の調査表を用いてリハビリメイクの精神心理学的効果を調べることにより、その意義を明らかにすることを目的とした｡方法:リハビリメイクを施行し、承諾の得られた187名(女性181名、男性6名、平均年齢34.9歳)を対象とした｡｢否定的自己認知｣に関する10項目、｢対人認知｣に関する11項目、｢強迫的思考｣に関する11項目からなるうつ病認知スケールを調査表として使用した｡各被験者について、この3項目とその総合評価を危険域（－1点)、中等度問題あり(0点)、問題なし(+1点)の3段階に分類し、施行前後の変化を点数化し、評価、検討を行った｡結果･結論:｢否定的自己認知｣に関して、危険域にあった人数は、リハビリメイク施行前後で、33名(17.6%)から11名(5.9%)に減少した｡同様に危険域にあった｢対人認知｣では、施行前40名(21.4%)、施行後20名(10.7%)、｢強迫的思考｣に関しては、施行前23名(12.3%)、施行後16名(8.6%)、また、総合評価については、施行前25名(13.4%)、施行後8名(4.3%)であった｡統計学的検定により、｢強迫的思考｣に関して有意水準5%未満、｢否定的自己認知｣、｢対人認知｣および総合評価に関しては有意水準1%未満で状態の改善を認めた｡以上の結果から、リハビリメイクが顔に何らかの外見的な障害を有する人に精神心理学的効果のあることが示唆された｡

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：新潟大学  

Purpose : The purpose of this study was to evaluate the efficacy of the anterior ratio for appropriate occlusal relation using measurements of mesiodistal crown widths. Materials and Methods : The subjects included 202 patients (71 males and 131 females) with skeletal Class Ⅲ, referred to the Orthodontic clinic of Niigata University Medical and Dental Hospital, and considered to be candidates for surgical treatments. The following cases were excluded from the subjects used in this study : those who had any missing teeth, congenital defects, prosthesis, interproximal fillings and differential mesiodistal crown widths of more than 0.5mm between the left and right anterior teeth including microdont and/or peg teeth. A diagnostic cast of each patient taken before treatment was used to measure the mesiodistal crown widths of the anterior teeth on the maxilla and mandible. These values were then measured using a vernier caliper with an accuracy of 1/20mm. Measurement values were taken using the mean score calculated based on two sets of measurements taken on separate days. An anterior ratio was calculated using this formula : Anterior ratio (%) = (mesiodistal crown widths of anterior teeth on mandible)/(mesiodistal crown widths of anterior teeth on maxilla) ×100 Results and Discussion : Results showed a difference between males and females in mesiodistal crown widths on the upper central incisors, upper and lower canines and lower lateral incisors, respectively. Measurement data is as follows (males and females, respectively) : upper central incisors ; 8.77±0.45 and 8.50±0.49, upper lateral incisors ; 7.27±0.60 and 7.18±0.61, upper canines ; 8.23±0.53 and 7.89±0.46, lower central incisors ; 5.51±0.35 and 5.45±0.40, lower lateral incisors ; 6.17±0.39 and 6.05±0.41, lower canines ; 7.22±0.45 and 6.86±0.46. The anterior ratio also showed a difference between males and females. These were 77.92±2.36% and 77.93±2.63% in males and females, respectively. The present data were smaller than those in similar reports as to patients with skeletal ClassⅢ, and were analogous to the data for patients with normal occlusion. These results suggest that even cases with antero-posterior dentofacial anomaly due to overgrowth of the mandible mostly have balanced mesiodistal crown widths of the upper and lower anteriors.本研究は、骨格性下顎前突症を有する患者の歯冠近遠心幅径を計測し、適切な咬合関係の確立に関与するanterior ratioについて検討することを目的とした｡資料と方法: 新潟大学医歯学総合病院矯正歯科診療室を受診し、骨格性下顎前突と診断され上下顎前歯部に欠損、補綴物、隣接面充填物がなく、矮小歯を含めて左右側の歯冠近遠心幅径の差が0.5mm以上ある症例を除いた202名(女性131名、男性71名)の歯列石膏模型を資料とした｡計測は資料とした模型について上下顎6前歯の歯冠近遠心幅径を、1/20mmの副尺付きのノギスを用いて行った｡計測は日を変えて2回行い、その平均値を測定値とした。 得られた測定値からanterior ratio(= (下顎6前歯の歯冠近遠心幅径の総和)/ (上顎6前歯の歯冠近遠心幅径の総和)×100)を算出した｡結果と結論: 測定した歯冠近遠心幅径(単位; mm)は、上顎中切歯が男性8.77±0.45で女性8.50±0.49、上顎側切歯が男性7.27±0.60で女性7.18±0.61、上顎犬歯が男性8.23±0.53で女性7.89±0.46、下顎中切歯が男性5.51±0.35で女性5.45±0.40、下顎側切歯が男性6.17±0.39で女性6.05±0.41、下顎犬歯が男性7.22±0.45で女性6.86±0.46、上顎中切歯、上下顎犬歯と下顎側切歯について危険率5%未満で男女差を認めた。また、anterior ratioは、男性が77.92±2.36%で女性が77.93±2.63%であった。今回算出した骨格性下顎前突患者のanterior ratioは、反対咬合者について調べた過去の報告と比べて小さい値を示し、正常者に近似していた｡以上の結果から、下顎骨過成長による上下顎骨の前後的不調和を示す症例でも、上下顎の前歯の歯冠近遠心幅径は調和がとれている場合の多いことが示された。

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BIOMEDICAL RESEARCH PRESS LTD  

Calcitonin gene-related peptide (CGRP) is a neuropeptide, which has multiple functions, and CGRP-containing nerves are prolific in the periodontal tissues., Tooth movement accompanies active tissue remodeling, including bone formation and resorption in the periodontal ligament. Although it has been suggested that CGRP contributes to tissue remodeling incident to tooth movement, little information is available for this issue. In the present study, immunohistochemistry combined with a computer-assisted quantitative analysis was employed to examine chronological changes in staining intensity for CGRP in osteoblasts during experimental tooth movement. The maxillary canine on one side was moved distally and fixed for 1 h to 56 days, leaving an untreated canine at the opposite side to serve as a control. Undecalcified sagittal sections of each maxilla, 6 im in thickness, were processed by immunohistochemistry for CGRP. The distal alveolar bone around the root apex was selected for the analysis because of active bone formation in this area, due to constant tension during tooth movement. Percent staining intensity (SI) for osteoblastic CGRP in the experimental and control groups was calculated using a Zeiss microphotometer equipped with a Microscope Analysis with Photometric Scanning (MAPS) program. The mean SI for CGRP increased daily, peaked at postoperative Day 7, and decreased gradually thereafter. The relative ratio of SI in the experimental and control groups was about 200% at 1 h postoperatively and increased to approximately 300% during postoperative Days 7-14. The surface area of CGRP-labeled osteoblasts also showed the same alternation pattern as that of SI. These findings indicate that CGRP is released from neurons and can be bound to osteoblasts, and that orthodontic forces can alter the levels of SI for CGRP, suggesting the involvement of CGRP in regulation of osteoblastic activity. High SI for CGRP in the osteoblasts at time periods when the surface area of osteoblasts was increased, suggests that CGRP possibly participates in mediating the effects of orthodontic forces on alveolar osteoblasts.

DOI： 10.2220/biomedres.25.147

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Blackwell Publishing Ltd  

Temporomandibular joint (TMJ) osteoarthritis (OA) is a potential cause of craniofacial deformity. If TMJ OA appears during orthodontic treatment, the mandible usually rotates posteriorly, resulting in an unsatisfactory profile, especially in patients with pre-treatment mandibular retrusion. Although it is important to confirm the kind of TMJ pathosis at the start of orthodontic treatment, the relationship between TMJ OA, condylar remodelling and changes in craniofacial morphology remains unclear because of a lack of longitudinal studies. Elucidating this relationship might allow better prediction of post-treatment craniofacial morphology. In the present case reports, helical computed tomography and cephalometry were used to analyse relationships between the pattern and location of condylar remodelling and the changes in craniofacial morphology in three patients with TMJ OA.

DOI： 10.1046/j.1365-2842.2003.01246.x

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本顎変形症学会  

In this study, changes in temporomandibular joint symptoms and mandibular stability after orthognathic surgery in patients with mandibular retrognathism were investigated. Eight patients were examined clinically for pain, sound, movement and limitation of TMJ and by computed tomography (CT) and lateral cephalograms. TMJ signs and symptoms disappeared in two of the symptomatic patients after surgery, whereas two of the asymptomatic patients developed TMJ signs and symptoms postoperatively. The incidences of TMJ signs and symptoms before treatment and a year after surgery were both 3/8 (27.5%). The position of the disk and the condylar morphology were evaluated with CT. Six patients had disk displacements before treatment and seven patients a year after surgery. Erosions and/or deformities of the condyles were observed in six patients before treatment and all (eight) patients a year after surgery. The diagnosis in five patients was progressive condylar resorption because the ramus vertical hights decreased more than 4mm and/or counterclockwise rotation of the proximal segment was observed on the cephalograms, and remarkable resorption was also identified on postoperative CT. There was no association between signs and symptoms of TMJ and CT findings. The mean anterior movement of the mandible at surgery was 10.1mm at pogonion, and the mean horizontal relapse was 4.1mm. Large horizontal relapses were recognized in cases with progressive condylar resorption.&lt;BR&gt;In conclusion, patients with large mandibular advancement and counterclockwise rotation at surgery and condylar erosive bone change at preoperative examination appear to be at risk for progressive condylar resorption, but the mechanism is obscure.

DOI： 10.5927/jjjd1991.12.9

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   出版者・発行元：一般社団法人 日本心身医学会  

DOI： 10.15064/jjpm.41.3_217_2

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本矯正歯科学会  

PURPOSE ; The purpose of this study was to investigate effects of two-stage palatoplasty combined with Hotz' plate on craniofacial development of mixed dentition patients with complete unilateral cleft lip and palate (UCLP). MATERIALS AND METHODS : The subjects selected for this study were 42 Japanese boys, 9 to 11 years old, from following three different groups : Group A (two-stage group) consisting of 15 UCLP subjects whose cleft palates were closed with two-stage palatoplasty combined with Hotz' plate (soft palatal closure at 18 months and hard palatal closure at 6 years) ; Group B (one-stage group) consisting of 14 subjects whose cleft palates were closed with one-stage palatoplasty within 2 years of age ; Group C (control group) consisting of 13 subjects who had non-cleft Class I occlusion. Lateral headfilms of each group (mean age=9.8, 10.0, 10.3 years for group A, B, C respectively) were examined. Cephalometric measurements including 14 angles, 7 distances, and 2 ratios were obtained and the findings from three groups were compared with each other by Fisher's PLSD (p<0.05). RESULTS : Measurements in which both Group A (two-stage group) and Group C (control group) showed significantly larger values than Group B (one-stage group) and there was no significant difference between Group A and C were SNA, ANB, and maxillary length. Measurements in which Group C showed significantly larger values than Group B and there was no significant difference between Group A and C were anterior upper facial height (AUFH) and ratio of AUFH to anterior lower facial height. Measurement in which both cleft groups (Group A and B) showed significantly smaller values than Group C (control group) and there was no significant difference between Group A and B was U1 to S-N in the non-cleft side. CONCLUSION : The findings in this study showed that craniofacial development up to mixed dentition in UCLP subjects with two-stage palatoplasty combined with Hotz's plate was better than that in UCLP subjects with one-stage palatal closure, and relatively similar to that of subjects with normal occlusion, indicating that this procedure for palatal closure could be advantageous for craniofacial development.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER ASSOC DENTAL RESEARCH  

It is known that orthodontic forces induce discomfort and/or abnormal sensation after application of an orthodontic appliance in patients, suggesting the adaptation of periodontal neural elements to environmental changes. However, no morphological data have been provided. The present study investigated, by immunoelectron microscopy, the localization of growth-associated protein-43 (GAP-43) in periodontal Ruffini endings in rat molars during experimental tooth movement. In the untreated control group, immunoelectron microscopy demonstrated that GAP-43-like immunoreactivity in the Ruffini endings was confined to the Schwann sheaths around the axon terminals, and was in neither the cell bodies of terminal Schwann cells nor the axon terminals themselves. Immunoelectron microscopic observation revealed alterations in the localization of GAP-43-like immunoreactivity in the periodontal Ruffini endings during experimental tooth movement. After 1 day of treatment, the cell bodies of the terminal Schwann cells associated with Ruffini endings appeared to contain immunoreaction products for GAP-43, and retained GAP-43-like immunoreactivity during tooth movement. From 5 to 7 days, a major population of the axoplasm of the periodontal Ruffini endings, which was immunonegative in control, filled the GAP-43 immunoreactions, showing a tendency to decrease in number later, and disappeared completely at 14 days. These findings suggest that orthodontic forces easily induce the remodeling of the mechanoreceptive Ruffini endings as well as the active tissue remodeling in a close relationship. Since the ultrastructural localization of GAP-43-like immunoreactivity was drastically changed in the Ruffini endings during tooth movement, GAP-43 functions as one of the key molecules in the remodeling of mechanoreceptive Ruffini endings during tooth movement.

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   出版者・発行元：Japanese Society of Oral and Maxillofacial Surgeons  

We describe a patient who underwent autotransplantation of a tooth to the maxillary molar region, which lacked adequate bone thickness from the alveolar crest to antral floor. The patient was 34-year-old man with a missing left maxillary second molar. The right mandibular premolar, which had to be extracted because of orthodontic reasons, was transplanted to the region. The apical half of the root of the transplanted tooth projecting into the maxillary sinus was covered with the sinusmucoperiostium, which was carefully detached from the floor, to preserve blood-circulation to periodontal cells. The pocket-depth, mobility, and percussion-sound of the transplanted tooth were normal, and the periodontal space and newly formed bone were observed radiographically around the root 6 months after transplantation. The findings indicated that a tooth can be successfully autotransplanted to a maxillary-molar region that lacks adequate alveolarbony thickness withont the use of a bone graft.

DOI： 10.5794/jjoms.43.754

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

The Trk family, a group of high-affinity neurotrophin receptors, is divided into three subtypes, TrkA, TrkB and TrkC. These were originally found in neural elements, and are involved in neural development, maintenance and survival. Recent studies have shown that non-neural cells in vitro also express mRNA encoding some neurotrophin receptors. In our preliminary study, TrkB-like immunoreactivity (LI) was found in the various non-neural cells in the rat periodontal ligament. The present study was undertaken to clarify which cell types express Trk-LI, in particular two types of TrkB-LI, in the periodontal ligament of mature rats? using an immunocytochemical technique with polyclonal antibodies. Intense full-length TrkB-LI was clearly recognized in non-neural cells such as fibroblasts, osteoclasts, odontoclasts and cementoblasts as well as in neural elements. Relatively large cells with many cytoplasmic processes were also frequently immunopositive for full-length TrkB. Immunocytochemistry for TrkB[TK-], a truncated type, also demonstrated a similar immunostaining pattern to that of full-length TrkB in non-neural periodontal cells, and intense positive reactions in endothelial cells. Some non-neural cells were positive for TrkA and TrkC. These findings suggest that neurotrophic factors, the ligands of the Trk family, have certain effects on the proliferation and/or differentiation of non-neural cells, as well as on their neurotrophic functions. (C) 1997 Elsevier Science Ltd.

DOI： 10.1016/S0003-9969(97)00030-7

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本矯正歯科学会  

近年, 思春期前においてすでにわずかながら顔面の非対称ないしは, 正中線の偏位を呈している症例を多く認めるようになったが, このような症例における偏位の様相の経年的変化に関する報告は少ない.今回は, 成長とともに偏位が著明になった反対咬合3症例を紹介し, 顎偏位度あるいは正中線の偏位など, その偏位様相の特徴について検討した.症例1 : 初診時年齢, 女子.顔面の正中に対して上顎, 下顎がわずかに右側に偏位し, 上下顎切歯の正中線のずれが5.5mmであった.では, 上顎骨および下顎骨の右側偏位が著しくなり, 顔面の非対称が著明になったが, 正中線のずれは5mmと, 初診の状態がほぼ維持されていた.症例2 : 初診時年齢, 女子.顔面の正中に対して下顎はわずかに左側に偏位しているが, 上顎に偏位はなく, 上下顎切歯の正中はほぼ一致していた.では, 下顎が著しく左側に偏位したことにより, 顔面正貌も非対称が顕著となった.正中線のずれは7mmと増悪した.症例3 : 初診時年齢, 女子.上顎は右側, 下顎は左側にわずかに偏位しており, 上下顎切歯の正中線のずれは3mmであった.では, 上顎は顔面の正中にほぼ一致していたが, 下顎が左側に大きく偏位し, 顔面正貌も著しく非対称となった.正中線のずれは4.5mmになった.以上のことから, 混合歯列期におけるわずかな偏位が, 思春期にさまざまな形で増悪する可能性が示され, このような症例では経年的な成長変化の詳細な検討が必要と考えられた.

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本矯正歯科学会  

本研究は, 指骨(5中手骨と14指節骨との両者とする)の長さと下顎骨の長さ(Condyle-Gonion間距離, Gonion-Pogonion間距離, Condyle-Pogonion間距離)の増齢に伴う変化がロジスティック曲線, Y=K/(1+A・e^-B・X)に適合するかどうか, さらにその曲線の特徴を調べることを目的とした.資料は, 新潟大学歯学部附属病院矯正科来院の患者で拇指尺側種子骨の出現前から女性満16歳, 男性満17歳以上で経年的に手と側面セファログラムがそれぞれ6枚以上ある日本人の女性15名と男性15名とした.全被験者の各計測項目について, ロジスティック曲線を求め, 適合を調べた.適合した曲線について, 曲線の描記, 係数Aの対数と係数Bとの散布図を作成してその特徴を分析した.全被験者の指骨と下顎骨の全計測項目についてロジスティック曲線に危険率5%レベルで適合した.指骨に関する曲線は幅広い変化を示し, 散布図では右上がりの帯状を呈し, 女性の値は帯の上方に位置していた.一方, 下顎骨ではCd-Pogの変化が最もばらつきの少ない曲線を示した.散布図は, Cd-Pogで楕円状の分布を, Cd-GoとGo-Pogで右上がりの帯状を呈した.個人の特徴を散布図で調べた結果, 全般的に指骨の値は右上がりで直線状に点在し, 下顎骨の値はこの直線の近くに点在していた.個人の指骨ならびに下顎骨の長さの経年的な変化をロジスティック曲線を用いて表すことが可能であることが示され, 併せてその曲線の係数は特徴的な散布図により表現することができた.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

This pilot study deals with the initial responses of neural elements showing nerve growth factor-receptor (NGFR) immunoreactivity in the periodontal ligament of rats to orthodontic forces. The animals were killed at intervals of 1, 2, 6, 12 h and 1, 3, 5, 7 days after the insertion of elastic bands between the maxillary first and second molars. Serial frozen sections. prepared from each animal, were processed immunohistochemically to demonstrate NGFR, after which the periodontal ligament of the mesial root of the maxillary second molar was examined microscopically. In control sections, NGFR-positive neural elements were predominantly distributed at the apex of the bony socket on the distal side of the periodontal ligament. After 1 h of tooth movement. NGFR positively-stained nerve fibres tended to disappear slightly in both the intermediate and coronal regions of the distal periodontal ligament. By the third day of tooth movement, the periodontal ligament nerve fibres showed more intense NGFR-immunoreactivity; thick, positively stained nerve fibres were recognized on the distal side in which active bone remodelling was occurring, and a few of these fibres were densely distributed around blood vessels or near Howship's lacunae. The distribution of NGFR-positive neural elements on the mesial side increased at 5 days of tooth movement. Finally, at 7 days of tooth movement, staining intensity for NGFR appeared to decrease. These findings demonstrate that an alteration in the distribution and the intensity of immunoreactive staining for NGFR in the periodontal ligament is associated with the bone remodelling induced by orthodontic tooth movement.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

Nerve fibres showing CGRP-immunoreactivity were exclusively distributed around blood vessels in the periodontal ligament of normal teeth. The CGRP-positive nerves as well as the vessels were more dense during tooth movement and reached a maximum density and intensity of immunoreaction after 3 days. After that, the immunoreactive nerves gradually disappeared, and returned to the control level by the 7th day. Some of the CGRP-nerves were adjacent to bone resorptive lacunae at 3 days when active remodelling of alveolar bone was taking place. These findings suggest that the distribution of CGRP-positive nerves is dynamically changed around the blood vessels in the periodontal ligament during tooth movement, and that CGRP might affect the regulation of blood flow in the ligament. CGRP is possibly involved in the tissue remodelling, directly or indirectly, in addition to its function as a neurotransmitter.

Web of Science

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

CiNii Article

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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J-GLOBAL

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記述言語：日本語   出版者・発行元：新潟歯学会  

本研究の目的は、正貌顔面規格写真を用いて骨格性下顎前突症例における正貌軟組織形態の計測結果をもとにクラスター分析を行い、分類された各群の特徴を明らかにすることである。対象は、骨格性下顎前突症と診断された100名(男性40名、女性60名)である。正貌顔面規格写真上に顔面構造物および顔面輪郭に計測点を設定し、7つの角度計測項目を定義し算出した。これらの計測結果をもとにクラスター分析にて正貌を分類し、各群における計測項目の結果について多群比較を行った。クラスター分析により4つの群に分類され、近似している群から順にA群、B群、C群、D群とした。4群の特徴を要約すると、A群(22名):顔面輪郭の非対称は強いが顔面構造物の位置の非対称が軽度、B群(9名):顔面構造物の位置の非対称および顔面輪郭の非対称が強い、C群(29名):顔面輪郭の非対称は軽度だが顔面構造物において鼻下点および上唇の非対称が強い、D群(40名):顔面構造物の位置の非対称と顔面輪郭の非対称の両方が軽度となった。以上のことから、A群はおもに下顎の偏位が大きく、B群は上下顎に偏位を持ち、また、C群は偏位が上顎に限局し、D群は顔面非対称が少ない群という特徴を有すると考えられた。本研究の結果、顔面構造物の位置の非対称と顔面輪郭形態の特徴から4群に分類することができ、顎偏位を伴う顎変形症例の治療計画立案に有用であると考えられた。(著者抄録)

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：克誠堂出版(株)  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語   出版者・発行元：甲北信越矯正歯科学会  

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語  

J-GLOBAL

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J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：新潟歯学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：新潟歯学会  

基底細胞母斑症候群NNevoid Basal Cell Carcinoma Syndromeは、GorlinとGoltzによって体系づけられた常染色体優性遺伝性疾患で、主に皮膚の多発性基底細胞母斑、基底細胞癌、顎骨の多発性角化嚢胞や、種々の骨格系統の異常を呈する症候群であるが、特に口腔領域では10代に多発する顎骨嚢胞が特徴的な疾患である。今回、複数の顎骨嚢胞、特に第二大臼歯の歯冠を含む巨大な含歯性嚢胞を有した症例に対し、10歳2ヵ月より16歳10ヵ月まで長期に渡って管理し、開窓術及び埋伏歯の矯正による牽引誘導を行うことで、嚢胞の縮小と良好な骨成長および咬合状態を得ることができた症例を経験したので、その治療経過と結果について報告する。また、巨大な含歯性嚢胞の埋状歯牽引の必要性について、その効果と限界について考察するとともに、基底細胞母斑症候群の患者に対する矯正治療の適応について考察した。(著者抄録)

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記述言語：日本語   出版者・発行元：新潟歯学会  

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記述言語：日本語   出版者・発行元：新潟歯学会  

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