Faculty Profiles - YOSHIHARA Akihiro

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YOSHIHARA Akihiro

Organization

Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Professor
Graduate School of Medical and Dental Sciences Oral Health and Welfare Science Oral Health and Welfare Professor

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Degree

博士(歯学) ( 1998.12 新潟大学 )

Research Areas

Life Science / Social dentistry

Research History (researchmap)

Niigata University Graduate School of Medical and Dental Sciences, Division of Oral Science for Health Promotion Professor

2011.9

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Niigata University Graduate School of Medical and Dental Sciences Oral Life Science Associate Professor

2007.4 - 2011.8

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Niigata University Graduate School of Medical and Dental Sciences Associate Professor (as old post name)

2001.11 - 2007.3

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Niigata University Assistant

1987.4 - 2001.1

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Research History

Niigata University Graduate School of Medical and Dental Sciences Master's Program of Oral Health and Welfare Science Dental Educational Research Development Division of Oral Science for Health Promotion Professor

2011.9
Niigata University Graduate School of Medical and Dental Sciences Oral Life Science Associate Professor

2007.4 - 2011.8
Niigata University Graduate School of Medical and Dental Sciences Associate Professor (as old post name)

2001.11 - 2007.3
Niigata University University Dental Hospital Research Assistant

1987.4 - 2001.1

Professional Memberships

The Japanese Society for Oral Health

1988.4

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IADR

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老年歯科医学会

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日本歯周病学会

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Japanese Society of Public Health

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Qualification acquired

Dentist

Papers

高齢者における血漿中抗Porphyromonas gingivalis抗体価と孤立性収縮期高血圧との関連

星野剛志, 金子昇, 葭原明弘, 岩崎正則, 諏訪間加奈, 小川祐司

日本歯科医師会雑誌 78 ( 4 ) 366 - 366 2025.7

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Language：Japanese Publisher：(公社)日本歯科医師会

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高齢者における牛乳・乳製品の摂取頻度と現在歯数の関連

平原茉結, 小田島あゆ子, 諏訪間加奈, 葭原明弘

新潟歯学会雑誌 55 ( 1 ) 21 - 22 2025.7

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Language：Japanese Publisher：新潟歯学会

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Dietary n-6 and n-3 Polyunsaturated Fatty Acids and Tooth Loss in Community-Dwelling Older Japanese People. International journal

Akihiro Yoshihara, Masanori Iwasaki, Kana Suwama, Ayuko Odajima, Keiko Kabasawa, Yumi Ito, Junta Tanaka

Gerodontology 2025.4

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Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: This study investigated the associations between baseline n-6 and n-3 polyunsaturated fatty acid levels and the number of teeth lost subsequently over 5 years. BACKGROUND: The relationship between n-3 and n-6 polyunsaturated fatty acids and tooth loss remains unclear. Previous studies have been limited to older individuals aged 70 and above, and no research has been conducted that takes into account a broader age range. MATERIAL AND METHODS: Participants (n = 1534) attended both the baseline survey and the follow-up survey conducted 5 years later. Poisson regression analyses were conducted after converting the number of teeth present at baseline into an adjustment variable. The dependent variable was the number of lost teeth over a five-year period. The exposure variables were each quintile of self-reported n-3 and n-6 polyunsaturated fatty acid intake levels (g/1000 kcal) and the ratio of self-reported n-6 to n-3 polyunsaturated fatty acid intake levels (n-6:n-3 ratio) adjusted by age, sex, smoking, use of dental floss or interdental brush and history of diabetes mellitus. RESULTS: Higher n-3 fatty acid intake (5th quintile, incidence rate ratio (IRR): 0.21, p < 0.001) and a lower dietary n-6:n-3 ratio (≤ 4.0) significantly lower tooth loss risk. Conversely, higher n-6 intake (5th quintile, IRR: 1.32, p = 0.006) was associated with the likelihood of tooth loss. Younger age, flossing and adequate chewing ability were associated with better dental outcomes. CONCLUSION: Balanced dietary intake, particularly higher n-3 fatty acids and a lower n-6:n-3 ratio, helps preserve dental health by reducing tooth loss risk.

DOI： 10.1111/ger.12819

PubMed

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独居高齢者における友愛訪問利用者の食事摂取多様性および主観的咀嚼能力の関連

小田島あゆ子, 島村陽南子, 中村健, 磯部澄枝, 石上和男, 葭原明弘

口腔衛生学会雑誌 75 ( 増刊 ) 135 - 135 2025.4

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Language：Japanese Publisher：(一社)日本口腔衛生学会

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通所介護を利用する高齢者におけるムセまたは咀嚼の問題とADLの関連

佐々木史佳, 小田島あゆ子, 葭原明弘

口腔衛生学会雑誌 75 ( 1 ) 37 - 38 2025.1

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地域在住自立高齢者を対象とした主観的幸福感と口腔機能低下症検査項目との関連

大西愛, 頭山高子, 柴田佐都子, 諏訪間加奈, 葭原明弘

新潟歯学会雑誌 54 ( 2 ) 100 - 101 2024.12

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Language：Japanese Publisher：新潟歯学会

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Weight Loss and Number of Present Teeth in Community-Dwelling Japanese Older Adults: A Cross-Sectional Study in Niigata. International journal

Sachiko Takehara, Masayuki Ueno, Akihiro Yoshihara, Masanori Iwasaki, Kana Suwama, Kumiko Minagawa, Ichiei Narita, Junta Tanaka, Hiroshi Ogawa, Yumi Ito

Journal of oral rehabilitation 2024.11

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Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND OBJECTIVES: Weight loss is a critical health issue among the older population. This study aimed to explore the association between weight loss and oral health in older adults. METHODS: We used cross-sectional data from the Uonuma Chronic Kidney Disease Cohort Study. The binary logistic regression models were fitted to estimate the relationship between weight loss and independent variables including the number of teeth present. RESULTS: The participants included 1656 females and 1625 males. There were 1217 females (73.4%) and 1236 males (76.0%) with normal BMI (18.5 ≤ BMI < 25) in the previous year. Weight loss was determined over a 12-month period. Individuals with normal BMI in previous year, and those with weight loss (≥ 5%) or those whom maintained a stable weight were further analysed. The regression analysis (model 3, fully adjusted) showed that females with 0 and 1-10 teeth present had a higher likelihood of losing weight (OR = 4.07; 95% CI = 1.85-8.93, OR = 2.33; 95% CI = 1.24-4.39) compared with those with 20 or more teeth. Current smokers had a higher likelihood of losing weight (OR = 3.15; 95% CI = 1.01-9.76) than lifelong abstainers. Among males, both current and previous smokers showed a higher likelihood of losing weight (OR = 4.94; 95%CI = 1.76-13.8, OR = 3.35; 95% CI = 1.29-8.68) than those who never smoked. CONCLUSIONS: This study indicates that the number of teeth and smoking are both linked to weight loss in females. However, in males, the association between the number of teeth and weight loss may be compromised due to the high prevalence of smoking in this group.

DOI： 10.1111/joor.13886

PubMed

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General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants

Bin Zhou, James E Bennett, Aidan P Wickham, Rosie K Singleton, Anu Mishra, Rodrigo M Carrillo-Larco, Nayu Ikeda, Lakshya Jain, Ana Barradas-Pires, Rachel A Heap, Victor PF Lhoste, Kate E Sheffer, Nowell H Phelps, Archie W Rayner, Edward W Gregg, Mark Woodward, Gretchen A Stevens, Maria LC Iurilli, Goodarz Danaei, Mariachiara Di Cesare, Carlos A Aguilar-Salinas, Noor Ani Ahmad, Pascal Bovet, Zhengming Chen, Albertino Damasceno, Sarah L Filippi, Imre Janszky, Andre P Kengne, Young-Ho Khang, Kamlesh Khunti, Avula Laxmaiah, Lee-Ling Lim, Lauren Lissner, Paula Margozzini, Jean Claude N Mbanya, Stephen T McGarvey, Jonathan E Shaw, Stefan Söderberg, Luis Adrián Soto-Mota, Junyang Wang, Francesco Zaccardi, Leandra Abarca-Gómez, Mohsen Abbasi-Kangevari, Shynar Abdrakhmanova, Suhaila Abdul Ghaffar, Hanan F Abdul Rahim, Zulfiya Abdurrahmonova, Niveen M Abu-Rmeileh, Benjamin Acosta-Cazares, Ishag Adam, Marzena Adamczyk, Wichai Aekplakorn, Imelda A Agdeppa, Javad Aghazadeh-Attari, Charles Agyemang, Mohamad Hasnan Ahmad, Ali Ahmadi, Naser Ahmadi, Nastaran Ahmadi, Soheir H Ahmed, Wolfgang Ahrens, Gulmira Aitmurzaeva, Kamel Ajlouni, Hazzaa M Al-Hazzaa, Halima Al-Hinai, Jawad A Al-Lawati, Rajaa Al-Raddadi, Deena Al Asfoor, Huda M Al Hourani, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Mohamed M Ali, Anna V Alieva, Abdullah Alkandari, Buthaina M Alkhatib, Eman Aly, Deepak N Amarapurkar, Pilar Amiano Etxezarreta, Norbert Amougou, Lars Bo Andersen, Sigmund A Anderssen, Odysseas Androutsos, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Elena Anufrieva, Hajer Aounallah-Skhiri, Tahir Aris, Raphael E Arku, Nimmathota Arlappa, Krishna K Aryal, Felix K Assah, Batyrbek Assembekov, Maria Cecília F Assunção, Juha Auvinen, Mária Avdičová, Kishwar Azad, Ana Azevedo, Mohsen Azimi-Nezhad, Fereidoun Azizi, Flora Bacopoulou, Suhad Bahijri, Izet Bajramovic, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R Banegas, Rafał Baran, Carlo M Barbagallo, Valter Barbosa Filho, Alberto Barceló, Maja Baretić, Joaquin Barnoya, Lena Barrera, Aluisio JD Barros, Mauro Virgílio Gomes Barros, Abdul Basit, Joao Luiz Bastos, Anwar M Batieha, Aline P Batista, Rosangela L Batista, Zhamilya Battakova, Louise A Baur, Pascal M Bayauli, Silvia Bel-Serrat, Antonisamy Belavendra, Habiba Ben Romdhane, Theodora Benedek, Judith Benedics, Mikhail Benet, Gilda Estela Benitez Rolandi, Michaela Benzeval, Elling Bere, Nicolas Berger, Ingunn Holden Bergh, Salim Berkinbayev, Antonio Bernabe-Ortiz, Heloísa Bettiol, Augustin F Beybey, Jorge Bezerra, Aroor Bhagyalaxmi, Santosh K Bhargava, Elysée Claude Bika Lele, Mukharram M Bikbov, Bihungum Bista, Dusko J Bjelica, Peter Bjerregaard, Espen Bjertness, Marius B Bjertness, Cecilia Björkelund, Katia V Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Lynne M Boddy, Bernhard O Boehm, Jose G Boggia, Elena Bogova, Marialaura Bonaccio, Alice Bonilla-Vargas, Herman Borghs, Steve Botomba, Rupert Bourne, Khadichamo Boymatova, Lutgart Braeckman, Tasanee Braithwaite, Imperia Brajkovich, Francesco Branca, Hermann Brenner, Lizzy M Brewster, Yajaira Briceño, Lacramioara Brinduse, Bettina Bringolf-Isler, Miguel Brito, Johannes Brug, Anna Bugge, Frank Buntinx, Marta Buoncristiano, Con Burns, Antonio Cabrera de León, Roberta B Caixeta, Tilema Cama, Günay Can, Ana Paula C Cândido, Felicia Cañete, Mario V Capanzana, Naděžda Čapková, Eduardo Capuano, Rocco Capuano, Vincenzo Capuano, Viviane C Cardoso, Axel C Carlsson, Felipe F Casanueva, Maribel Casas, Laura Censi, Marvin Cervantes‐Loaiza, Parinya Chamnan, Snehalatha Chamukuttan, Queenie Chan, Nish Chaturvedi, Fangfang Chen, Huashuai Chen, Long-Sheng Chen, Yiling J Cheng, Bahman Cheraghian, Angela Chetrit, Ekaterina Chikova-Iscener, Mai JM Chinapaw, Anne Chinnock, Arnaud Chiolero, Adela Chirita-Emandi, María-Dolores Chirlaque, Chean Lin Chong, Diego G Christofaro, Jerzy Chudek, Renata Cifkova, Massimo Cirillo, Frank Claessens, Philip Clare, Emmanuel Cohen, Susana C Confortin, Tara C Coppinger, Lilia Yadira Cortés, Cojocaru R Cosmin, Simona Costanzo, Melanie J Cowan, Chris Cowell, Amelia C Crampin, Amanda J Cross, Ana B Crujeiras, Juan J Cruz, Alexandra M Cucu, Felipe V Cureau, Sarah Cuschieri, Graziella D'Arrigo, Eleonora d'Orsi, Haroldo da Silva-Ferreira, Christina C Dahm, Jean Dallongeville, Rachel Dankner, Kairat Davletov, Francisco de Assis Guedes de Vasconcelos, Maria Alice Altenburg de Assis, Dirk De Bacquer, Jaco De Bacquer, Jeroen de Bont, Amalia De Curtis, Patrícia de Fragas Hinnig, Giovanni de Gaetano, Stefaan De Henauw, Pilar De Miguel-Etayo, Paula Duarte de Oliveira, Karina Mary de Paiva, Karin De Ridder, Marco Aurélio de Valois Correia Júnior, Mohan Deepa, Vincent Jr DeGennaro, Stefaan Demarest, Elaine Dennison, Valérie Deschamps, Meghnath Dhimal, María Pilar Díez Ripollés, Zivka Dika, Shirin Djalalinia, Liria Dominguez, Maria Benedetta Donati, Chiara Donfrancesco, Guanghui Dong, Silvana P Donoso, Maria Dorobantu, Marcus Dörr, Nico Dragano, Wojciech Drygas, Shufa Du, Charmaine A Duante, Priscilla Duboz, Rosemary B Duda, Vesselka L Duleva, Anar Dushpanova, Azhar Dyussupova, Elzbieta Dziankowska-Zaborszczyk, Narges Ebrahimi, Guadalupe Echeverría, Ricky Eddie, Ebrahim Eftekhar, Vasiliki Efthymiou, Eruke E Egbagbe, Sareh Eghtesad, Ulf Ekelund, Mohammad El-Khateeb, Jalila El Ati, Roberto Elosua, Ofem Enang, Rajiv T Erasmus, Cihangir Erem, Gul Ergor, Louise Eriksen, Johan G Eriksson, Jorge Escobedo-de la Peña, Ali Esmaeili, Roger G Evans, Ildar Fakhradiyev, Albina A Fakhretdinova, Caroline H Fall, Elnaz Faramarzi, Mojtaba Farjam, Farshad Farzadfar, Yosef Farzi, Mohammad Reza Fattahi, Asher Fawwad, Francisco J Felix-Redondo, Trevor S Ferguson, Romulo A Fernandes, Daniel Fernández-Bergés, Desha R Fernando, Daniel Ferrante, Gerson Ferrari, Marika Ferrari, Catterina Ferreccio, Eldridge Ferrer, Thamara Hubler Figueiró, Anna Fijalkowska, Günther Fink, Mauro Fisberg, Maria Forsner, Edward F Fottrell, Heba M Fouad, Damian K Francis, Guillermo Frontera, Flavio D Fuchs, Sandra C Fuchs, Viktoriya Furdela, Takuro Furusawa, Stefan Adela Gabriela, Zbigniew Gaciong, Manuel Galán Cuesta, Andrzej Galbarczyk, Sonya V Galcheva, Myriam Galfo, Manoli Garcia-de-la-Hera, Pablo Garcia, Sarah P Garnett, Magda Gasull, Andrea Gazzinelli, Ulrike Gehring, Eva Gerdts, Ebrahim Ghaderi, Seyyed-Hadi Ghamari, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Anup Ghimire, Alessandro Gialluisi, Simona Giampaoli, Francesco Gianfagna, Glen Gironella, Aleksander Giwercman, Konstantinos Gkiouras, Natalya Glushkova, Ramesh Godara, Justyna Godos, Marcel Goldberg, Georgina Gómez, Jesús Humberto Gómez Gómez, Luis F Gomez, Santiago F Gómez, Aleksandra Gomula, Bruna Gonçalves Cordeiro da Silva, Helen Gonçalves, Mauer Gonçalves, Ana D González-Alvarez, David A Gonzalez-Chica, Esther M González-Gil, Marcela Gonzalez-Gross, Juan P González-Rivas, Angel R Gonzalez, Frederic Gottrand, Dušan Grafnetter, Aneta Grajda, Maria G Grammatikopoulou, Tomasz Grodzicki, Else Karin Grøholt, Anders Grøntved, Viviana Guajardo, Pilar Guallar-Castillón, Maëlenn Guerchet, Ramiro Guerrero, Andre L Guimaraes, Unjali P Gujral, Martin C Gulliford, Marc J Gunter, Rajeev Gupta, Oye Gureje, Mirjana A Gurinović, Beata Gurzkowska, Laura Gutierrez, Xinyi Gwee, Rosa Haghshenas, Hamid Hakimi, Jytte Halkjær, Ian R Hambleton, Behrooz Hamzeh, Willem A Hanekom, Dominique Hange, Abu AM Hanif, Sari Hantunen, Jie Hao, Carla Menêses Hardman, Louise Hardy, Rachakulla Hari Kumar, Javad Harooni, Seyed Mohammad Hashemi-Shahri, Maria Hassapidou, Jun Hata, Teresa Haugsgjerd, Mirjam Heinen, Marleen Elisabeth Hendriks, Rafael dos Santos Henrique, Ana Henriques, Leticia Hernandez Cadena, Sauli Herrala, Marianella Herrera-Cuenca, Victor M Herrera, Isabelle Herter-Aeberli, Karl-Heinz Herzig, Ramin Heshmat, Allan G Hill, Sai Yin Ho, Michelle Holdsworth, Reza Homayounfar, Clara Homs, Emiel O Hoogendijk, Andrea RVR Horimoto, Claudia M Hormiga, Bernardo L Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, José María Huerta, Ilpo Tapani Huhtaniemi, Laetitia Huiart, Constanta Huidumac Petrescu, Martijn Huisman, Abdullatif Husseini, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Ellina M Iakupova, Anna G Iannone, Jannicke Igland, Chinwuba Ijoma, Violeta Iotova, Vilma E Irazola, Takafumi Ishida, Godsent C Isiguzo, Muhammad Islam, Sheikh Mohammed Shariful Islam, Duygu Islek, Till Ittermann, Ivaila Y Ivanova-Pandourska, Masanori Iwasaki, Tuija Jääskeläinen, Rod T Jackson, Hashem Y Jaddou, Michel Jadoul, Tazeen Jafar, Nataša Jan, Edward Janus, Juel Jarani, Gerald Jarnig, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Anjani Kumar Jha, Ramon O Jimenez, Karl-Heinz Jöckel, Michel Joffres, Jari J Jokelainen, Jost B Jonas, Pradeep Joshi, Rohina Joshi, Josipa Josipović, Farahnaz Joukar, Jacek J Jóźwiak, Anne Juolevi, Vesna Juresa, Vesna Jureša, Rudolf Kaaks, Felix O Kaducu, Agnes L Kadvan, Anthony Kafatos, Eero O Kajantie, Natia Kakutia, Daniela Kállayová, Zhanna Kalmatayeva, Ofra Kalter-Leibovici, Srinivasan Kannan, Efthymios Kapantais, Eva Karaglani, Argyro Karakosta, Khem B Karki, Adoubi Kassi Anicet, Marzieh Katibeh, Prasad Katulanda, Peter T Katzmarzyk, Jussi Kauhanen, Gyulli M Kazakbaeva, François F Kaze, Calvin Ke, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Cecily Kelleher, Han CG Kemper, Maryam Keramati, Mathilde Kersting, Yousef Saleh Khader, Arsalan Khaledifar, Davood Khalili, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ursula Kiechl-Kohlendorfer, Sophia J Kiechl, Stefan Kiechl, Hyeon Chang Kim, Heidi Klakk, Suntara Klanarong, Jana Klanova, Magdalena Klimek, Michael Knoflach, Susanne Kobel, Bhawesh Koirala, Elin Kolle, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Magdalena Korzycka, Jelena Kos, Seppo Koskinen, Malik Koussoh Simone, Éva Kovács, Irina Kovalskys, Sudhir Kowlessur, Slawomir Koziel, Jana Kratenova, Wolfgang Kratzer, Susi Kriemler, Peter Lund Kristensen, Helena Krizan, Maria F Kroker-Lobos, Steinar Krokstad, Herculina S Kruger, Ruan Kruger, Łukasz Kryst, Ruzena Kubinova, Urho M Kujala, Enisa Kujundzic, Zbigniew Kulaga, Mukhtar Kulimbet, Meena Kumari, Marie Kunešová, Pawel Kurjata, Catherine Kyobutungi, Quang Ngoc La, Demetre Labadarios, Carl Lachat, Daphne Lai, Youcef Laid, Lachmie Lall, Maritza Landaeta Jimenez, Edwige Landais, Tiina Lankila, Vera Lanska, Georg Lappas, Bagher Larijani, Mina P Lateva, Tint Swe Latt, Martino Laurenzi, Maria Lazo-Porras, Gwenaëlle Le Coroller, Khanh Le Nguyen Bao, Terho Lehtimäki, Daniel Lemogoum, Elvynna Leong, Justyna Leszczak, Gabriel M Leung, Yanping Li, Merike Liivak, Charlie Lim, Wei-Yen Lim, M Fernanda Lima-Costa, Hsien-Ho Lin, Lars Lind, Mieczyslaw Litwin, Liping Liu, Xiaotian Liu, Guadalupe Longo Abril, Oscar Lopes, Esther Lopez-Garcia, José Francisco López-Gil, Tania Lopez, José Eugenio Lozano, Janice L Lukrafka, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Charles Lunogelo, Michala Lustigová, Jean-René M'Buyamba-Kabangu, George LL Machado-Coelho, Aristides M Machado-Rodrigues, Enguerran Macia, Ahmed A Madar, Gladys E Maestre, Stefania Maggi, Dianna J Magliano, Sara Magnacca, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marcia Makdisse, Mohammad-Reza Malekpour, Fatemeh Malekzadeh, Reza Malekzadeh, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Lynell V Maniego, Yannis Manios, Jim I Mann, Fariborz Mansour-Ghanaei, Enzo Manzato, Mala Ali Mapatano, Rosu Maria-Magdalena, Joany Mariño, Anastasia Markaki, Larissa Pruner Marques, Jaume Marrugat, Reynaldo Martorell, Katharina Maruszczak, Giovanna Masala, Luis P Mascarenhas, Mannix Masimango Imani, Masoud Masinaei, Ellisiv B Mathiesen, Alicia Matijasevich, Piotr Matłosz, Tandi E Matsha, Victor Matsudo, Giletta Matteo, Pallab K Maulik, Christina Mavrogianni, Anselmo J Mc Donald Posso, Shelly R McFarlane, Rachael M McLean, Sounnia Mediene Benchekor, Kirsten Mehlig, Amir Houshang Mehrparvar, Jesus D Melgarejo, Fabián Méndez, Carlos O Mendivil, Carlos Mendoza Montano, Ana Maria B Menezes, Gert BM Mensink, Alibek Mereke, Indrapal I Meshram, Diane T Meto, Haakon E Meyer, Jie Mi, Karolina Miłkowska, Jody C Miller, Olga Milushkina, Cláudia S Minderico, GK Mini, Juan Francisco Miquel, J Jaime Miranda, Mohammad Reza Mirjalili, Marjeta Mišigoj-Duraković, Antonio Mistretta, Veronica Mocanu, Pietro A Modesti, Sahar Saeedi Moghaddam, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Niels C Møller, Dénes Molnár, Amirabbas Momenan, Charles K Mondo, Michele M Monroy-Valle, Roger A Montenegro Mendoza, Eric Monterrubio-Flores, Kotsedi Daniel K Monyeki, Jin Soo Moon, Mahmood Moosazadeh, Farhad Moradpour, Leila B Moreira, Alain Morejon, Luis A Moreno, Karen Morgan, George Moschonis, Alireza Moslem, Mildrey Mosquera, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Mohammad Esmaeel Motlagh, Jorge Motta, Marcos André Moura-dos-Santos, Malay K Mridha, Kelias P Msyamboza, Thet Thet Mu, Florian Muca, Boban Mugoša, Patricia B Munroe, Jaakko Mursu, Kamarul Imran Musa, Sanja Musić Milanović, Vera Musil, Geofrey Musinguzi, Norlaila Mustafa, Muel Telo Marie-Claire Muyer, Iraj Nabipour, Balkish M Naidu, Farid Najafi, Hanna Nalecz, Jana Námešná, KM Venkat Narayan, Take Naseri, Michels Nathalie, Nareemarn Neelapaichit, Azim Nejatizadeh, Ilona Nenko, Flavio Nervi, Hannelore K Neuhauser, Tze Pin Ng, Chung T Nguyen, Quang V Nguyen, Quang Ngoc Nguyen, Michael Y Ni, Peng Nie, Ramfis E Nieto-Martínez, Teemu J Niiranen, Toshiharu Ninomiya, Nobuo Nishi, Sania Nishtar, Marianna Noale, Oscar A Noboa, Helena Nogueira, Kevin I Norton, Davide Noto, Natalia Nowak-Szczepanska, Mohannad Al Nsour, Irfan Nuhoğlu, Eha Nurk, Fred Nuwaha, Moffat Nyirenda, Terence W O'Neill, Caleb Ochimana, Angélica M Ochoa-Avilés, Eiji Oda, Augustine N Odili, Kyungwon Oh, Ryutaro Ohtsuka, Brian Oldenburg, Valérie Olié, Mohd Azahadi Omar, Saeed M Omar, Altan Onat, Sok King Ong, N Charlotte Onland-Moret, Lariane M Ono, Obinna Onodugo, Pedro Ordunez, Rui Ornelas, Ana P Ortiz, Pedro J Ortiz, Clive Osmond, Sergej M Ostojic, Afshin Ostovar, Johanna A Otero, Charlotte B Ottendahl, Akaninyene Otu, Kim Overvad, Ellis Owusu-Dabo, Cristina P Padez, Ioannis Pagkalos, Natalja Pajula, Alberto Palloni, Luigi Palmieri, Wen-Harn Pan, Francesco Panza, Mariela Paoli, Sousana K Papadopoulou, Rossina G Pareja, Soon-Woo Park, Suyeon Park, Winsome R Parnell, Mahboubeh Parsaeian, Ionela M Pascanu, Patrick Pasquet, Nikhil D Patel, Halyna Pavlyshyn, Raimund Pechlaner, Ivan Pećin, João M Pedro, Sergio Viana Peixoto, Markku Peltonen, Alexandre C Pereira, Karen GDA Peres, Marco A Peres, Agustín Perez-Londoño, Cynthia M Pérez, Valentina Peterkova, Olga Petrovna Kovtun, Niloofar Peykari, Son Thai Pham, Rafael N Pichardo, Preux Pierre-Marie, Hynek Pikhart, Aida Pilav, Pavel Piler, Aleksandra Piwonska, Andreia N Pizarro, Silvia Plata, Raluca M Pop, Barry M Popkin, Stevo R Popovic, Miquel Porta, Anil Poudyal, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J Price, Antonio Prista, Rui Providencia, Jardena J Puder, Iveta Pudule, Soile Puhakka, Maria Puiu, Margus Punab, Mostafa Qorbani, Anna Quialheiro, Hedley K Quintana, Pedro J Quiroga-Padilla, Tran Quoc Bao, Stefan Rach, Salar Rahimikazerooni, Mahmudur Rahman, Olli Raitakari, Sherali Rakhmatulloev, Ivo Rakovac, Ambady Ramachandran, Otim PC Ramadan, Manuel Ramirez-Zea, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Sheena E Ramsay, João FLB Rangel Junior, Daniel A Rangel Reina, Lalka S Rangelova, Vayia Rarra, Mohammad-Mahdi Rashidi, Cassiano Ricardo Rech, Josep Redon, Valéria Regecová, Jane DP Renner, Judit A Repasy, Cézane P Reuter, Luis Revilla, Andrew Reynolds, Negar Rezaei, Abbas Rezaianzadeh, Elio Riboli, Fernando Rigo, Attilio Rigotti, Leanne M Riley, Tobias F Rinke de Wit, Ulf Risérus, Raphael M Ritti-Dias, Reina G Roa, Romana Roccaldo, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A Rodríguez-Villamizar, Andrea Y Rodríguez, Ulla Roggenbuck, Peter Rohloff, Rosalba Rojas-Martinez, Elisabetta L Romeo, Rafaela V Rosario, Annika Rosengren, Ian Rouse, Adolfo Rubinstein, Blanca Sandra Ruiz-Betancourt, Maria Ruiz-Castell, Emma Ruiz Moreno, Iuliia A Rusakova, Wojciech Rusek, Petra Rust, Marcin Rutkowski, Marge Saamel, Hamideh Sabbaghi, Harshpal S Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Sare Safi, Mohammad Hossien Saghi, Olfa Saidi, Calogero Saieva, Satoko Sakata, Nader Saki, Sanja Šalaj, Eduardo Salazar Martinez, Akkumis Salkhanova, Jukka T Salonen, Margarita Samoutian, Jose Sánchez-Abanto, Inés Sánchez Rodríguez, Diana A Santos, Ina S Santos, Maria Paula Santos, Tamara R Santos, Jouko L Saramies, Luis B Sardinha, Giselle Sarganas, Nizal Sarrafzadegan, Kai-Uwe Saum, Stefan Savin, Mariana Sbaraini, Marcia Scazufca, Beatriz D Schaan, Anja Schienkiewitz, Karin Schindler, Sabine Schipf, Amand Floriaan Schmidt, Börge Schmidt, Carsten O Schmidt, Ben Schöttker, Sara Schramm, Stine Schramm, Helmut Schröder, Constance Schultsz, Aletta E Schutte, Sylvain Sebert, Moslem Sedaghattalab, Aye Aye Sein, Abhijit Sen, Sadaf G Sepanlou, Guillermo Sequera, Ľudmila Ševčíková, Ronel Sewpaul, Teresa Shamah-Levy, Seyed Morteza Shamshirgaran, Maryam Sharafkhah, Sanjib K Sharma, Almaz Sharman, Amaneh Shayanrad, Ali Akbar Shayesteh, Lela Shengelia, Kenji Shibuya, Hana Shimizu-Furusawa, Rahman Shiri, Marat Shoranov, Namuna Shrestha, Khairil Si-Ramlee, Abla M Sibai, Labros S Sidossis, Antonio M Silva, Caroline Ramos de Moura Silva, Diego Augusto Santos Silva, Kelly Samara Silva, Xueling Sim, Mary Simon, Michael Sjöström, Natalia A Skoblina, Jolanta Slowikowska-Hilczer, Przemysław Slusarczyk, Liam Smeeth, Lee Smith, Fernanda Cunha Soares, Grzegorz Sobek, Eugène Sobngwi, Morten Sodemann, Agustinus Soemantri, Vincenzo Solfrizzi, Mohammad Hossein Somi, Elin P Sørgjerd, Maroje Sorić, Victoria E Soto-Rojas, Aïcha Soumaré, Alfonso Sousa-Poza, Igor Spiroski, Jan A Staessen, Andreas Stang, Jostein Steene-Johannessen, Peter Stehle, Aryeh D Stein, George S Stergiou, Jakub Stokwiszewski, Ekaterina Stoyanova, Gareth Stratton, Karien Stronks, Lela Sturua, Milton F Suarez-Ortegón, Phalakorn Suebsamran, Gerhard Sulo, Johan Sundström, Paibul Suriyawongpaisal, Boyd A Swinburn, René Charles Sylva, Lucjan Szponar, E Shyong Tai, Konstantinos D Tambalis, Abdonas Tamosiunas, Baimakhan Tanabayev, Maya Tanrygulyyeva, Mohammed Rasoul Tarawneh, Jakob Tarp, Carolina B Tarqui-Mamani, Radka Taxová Braunerová, Saskia Te Velde, William R Tebar, Grethe S Tell, Tania Tello, KR Thankappan, Xenophon Theodoridis, Sathish Thirunavukkarasu, Nihal Thomas, Amanda G Thrift, Ľubica Tichá, Erik J Timmermans, Dwi Hapsari Tjandrarini, Anne Tjonneland, Janne S Tolstrup, Murat Topbas, Laura Torres-Collado, Giota Touloumi, Pierre Traissac, Areti Triantafyllou, Atul Trivedi, Lechaba Tshepo, Panagiotis Tsintavis, John Tuitele, Azaliia M Tuliakova, Marshall K Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Maria L Turley, Evangelia Tzala, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Eunice Ugel, Flora AM Ukoli, Zhamyila Usupova, Hannu MT Uusitalo, Nalan Uysal, Gonzalo Valdivia, Damaskini Valvi, Rob M van Dam, Bert-Jan van den Born, Johan Van der Heyden, Yvonne T van der Schouw, Wendy Van Lippevelde, Hoang Van Minh, Natasja M Van Schoor, Irene GM van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Gregorio Varela-Moreiras, Luz Nayibe Vargas, Senthil K Vasan, Daniel G Vasques, Tomas Vega, Gustavo Velasquez-Melendez, Biruta Velika, Charlotte Verdot, Maïté Verloigne, Giovanni Veronesi, WM Monique Verschuren, Roosmarijn Verstraeten, Lucie Viet, Frøydis N Vik, Monica Vilar, Salvador Villalpando, Jesus Vioque, Jyrki K Virtanen, Marjolein Visser, Bharathi Viswanathan, Mihaela Vladulescu, Henry Völzke, Ari Voutilainen, Martine Vrijheid, Alisha N Wade, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo de Souza Wanderley Júnior, Chongjian Wang, Huijun Wang, Ningli Wang, Qian Wang, Xiangjun Wang, Ya Xing Wang, Ying-Wei Wang, S Goya Wannamethee, Nicholas Wareham, Olivia Wartha, Adelheid Weber, Karen Webster-Kerr, Niels Wedderkopp, Daniel Weghuber, Wenbin Wei, Leo Westbury, Peter H Whincup, Kremlin Wickramasinghe, Kurt Widhalm, Indah S Widyahening, Andrzej Więcek, Rainford J Wilks, Karin Willeit, Peter Willeit, Julianne Williams, Tom Wilsgaard, Bogdan Wojtyniak, Roy A Wong-McClure, Andrew Wong, Emily B Wong, Frederick C Wu, Justyna Wyszyńska, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Li Yan, Weili Yan, Yang Yang, Martha Yépez García, Moein Yoosefi, Akihiro Yoshihara, Novie O Younger-Coleman, Yu-Ling Yu, Yunjiang Yu, Ahmad Faudzi Yusoff, Vassilis Zafiropulos, Ahmad A Zainuddin, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Maria Elisa Zapata, Ko Ko Zaw, Tomasz Zdrojewski, Magdalena Żegleń, Kristyna Zejglicova, Tajana Zeljkovic Vrkic, Bing Zhang, Zhen-Yu Zhang, Yanitsa V Zhecheva, Bekbolat Zholdin, Paul Zimmet, Marie Zins, Julio Zuñiga Cisneros, Monika Zuziak, Majid Ezzati

The Lancet 404 ( 10455 ) 851 - 863 2024.8

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Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/s0140-6736(24)01405-3

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Association Between Low Kidney Function and Excess Weight Concerning Unfavourable Periodontal Health among Community-dwelling Older Japanese Women. International journal

Akihiro Yoshihara, Masanori Iwasaki, Kana Suwama, Kazutoshi Nakamura

Oral health & preventive dentistry 22 293 - 300 2024.7

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PURPOSE: To investigate the association of low renal function and overweight with poor periodontal condition in community-dwelling older Japanese women. MATERIALS AND METHODS: In total, 359 older women (age range: 55-74 years) participated in this study. Two periodontal parameters - the number of teeth with a probing pocket depth (PPD) or clinical attachment level (CAL) ≥ 4 mm - were used as the dependent variables. The principal independent variables were low renal function as defined by the estimated glomerular filtration rate (eGFR) and overweight as defined by the body mass index. Poisson regression analysis was used to calculate the ratio of means (RM). RESULTS: The RMs of the number of teeth with a PPD or CAL ≥ 4 mm in an adjusted model without an interaction term were 1.21- or 1.27-fold higher among those with an eGFR < 60, while those among the participants with an eGFR < 60 in the adjusted model with interaction terms for the number of teeth with a PPD or CAL ≥ 4 mm were 1.43- or 1.36-fold higher. In addition, increments of periodontal risk with low renal function and overweight showed a slightly smaller to negative trend. CONCLUSION: The present findings suggest a connection between unfavourable periodontal health and both renal function and being overweight among older Japanese women. A weak negative interaction was also found between poor renal condition and overweight in relation to periodontal condition.

DOI： 10.3290/j.ohpd.b5573943

PubMed

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UCP2 polymorphisms, daily step count, and number of teeth associated with all-cause mortality risk in Sado City: A hospital-based cohort study

Han Lyu, Noriko Sugita, Shigeki Komatsu, Minako Wakasugi, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kenji Sato, Hiroyuki Kawashima, Osamu Onodera, Ichiei Narita, Koichi Tabeta

Heliyon 10 ( 12 ) e32512 - e32512 2024.6

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Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.heliyon.2024.e32512

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地域在住高齢者における咬合と頭部を含む身体動揺との関連

小田島あゆ子, 葭原明弘, 久保雅義, 石上和男

老年歯科医学 39 ( 1 ) 57 - 64 2024.6

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Language：Japanese Publisher：(一社)日本老年歯科医学会

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J02171&link_issn=&doc_id=20240830160014&doc_link_id=10.11259%2Fjsg.39.1_57&url=https%3A%2F%2Fdoi.org%2F10.11259%2Fjsg.39.1_57&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif
独居高齢者における栄養摂取状況および口腔健康状態の実態調査

島村陽南子, 小田島あゆ子, 中村健, 松田正史, 松田浩一郎, 石上和男, 葭原明弘

日本老年歯科医学会総会・学術大会プログラム・抄録集 35回 O3 - 2 2024.6

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成人期における歯科保健行動の実態と関連する要因について

島村陽南子, 小田島あゆ子, 笹嶋真嵩, 江邉真奈美, 葭原明弘

口腔衛生学会雑誌 74 ( 2 ) 148 - 148 2024.4

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高齢者の認知検査に影響を与える因子についての疫学的探索

角田衣理加, 大島朋子, 小川祐司, 金子昇, 濃野要, 野村義明, 花田信弘, 葭原明弘

口腔衛生学会雑誌 74 ( 増刊 ) 139 - 139 2024.4

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歯科衛生士養成校学生の臨床実習におけるストレス反応の実態と関連要因 Reviewed

鈴鹿祐子, 大川由一, 諏訪間加奈, 黒川孝一, 葭原明弘, 千葉県歯科衛生士会

日本歯科衛生学会雑誌 18 ( 2 ) 26 - 37 2024.2

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Association between dry eye and periodontal disease in community-dwelling Japanese adults: data from the Uonoma cohort study Reviewed

Kaung Myat Thwin, Noboru Kaneko, Hikaru Okubo, Takayuki Yamaga, Kana Suwama, Akihiro Yoshihara, Masanori Iwasaki, Yumi Ito, Junta Tanaka, Ichiei Narita, Hiroshi Ogawa

BMC Oral Health（査読あり） 8 ( 24 ) 47 2024.1

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Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

While research has explored the risk of periodontal disease in various eye conditions, the link between dry eye and periodontal disease remains underexplored, especially in Japanese adults. This study aims to investigate the association between dry eye and periodontal disease in community-dwelling Japanese adults.

Methods

This study is a subset of the Uonuma cohort study, which includes Japanese adults aged 40 years and older residing in the Uonuma area of Niigata Prefecture, Japan. Participants completed a self-administered, paper-based questionnaire. Statistical analyses, including the chi-square test, independent t test, ANOVA test, and logistic regressions, were employed to assess the association of periodontal disease with independent variables.

Results

Among 36,488 participants (average age 63.3 years, 47.4% men), 39.3% had a history of periodontal disease, and gender differences were statistically significant (p < 0.001). Significant associations were found between periodontal disease and dry eye diagnosis or symptoms. Univariable logistic regression revealed links between periodontal disease and age, gender, living status, alcohol consumption, remaining teeth, bite molar availability, and history of dry eye disease or symptoms. Multiple-adjusted regression found that doctor-diagnosed dry eye was associated with a higher likelihood of periodontal disease (odds ratio, 1.12; 95% confidence interval, 1.03–1.22). Participants who never experienced dryness or foreign body sensation had lower ORs of periodontal disease than those who always experienced such symptoms across all models.

Conclusion

A significant correlation was found between dry eye and periodontal disease in Japanese adults. Regular check-ups, early detection, and effective management of both conditions are strongly recommended.

DOI： 10.1186/s12903-023-03773-7

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Other Link： https://link.springer.com/article/10.1186/s12903-023-03773-7/fulltext.html
歯科診療所通院患者における不安の要因に関する研究 Modified Dental Anxiety Scale日本語版(MDAS-J)を用いた分析

筒井紀子, 諏訪間加奈, 柴田佐都子, 長谷川優, 葭原明弘

新潟歯学会雑誌 53 ( 2 ) 57 - 63 2024.1

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歯科診療所通院患者における不安の要因に関する研究 Modified Dental Anxiety Scale日本語版(MDAS-J)を用いた分析 Reviewed

筒井紀子, 諏訪間加奈, 柴田佐都子, 葭原明弘

新潟歯学会雑誌 53 ( 2 ) 5 - 11 2023.12

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Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c Reviewed

Bin Zhou, Kate E. Sheffer, James E. Bennett, Edward W. Gregg, Goodarz Danaei, Rosie K. Singleton, Jonathan E. Shaw, Anu Mishra, Victor P. F. Lhoste, Rodrigo M. Carrillo-Larco, Andre P. Kengne, Nowell H. Phelps, Rachel A. Heap, Archie W. Rayner, Gretchen A. Stevens, Chris J. Paciorek, Leanne M. Riley, Melanie J. Cowan, Stefan Savin, Stephen Vander Hoorn, Yuan Lu, Meda E. Pavkov, Giuseppina Imperatore, Carlos A. Aguilar-Salinas, Noor Ani Ahmad, Ranjit Mohan Anjana, Kairat Davletov, Farshad Farzadfar, Clicerio González-Villalpando, Young-Ho Khang, Hyeon Chang Kim, Tiina Laatikainen, Avula Laxmaiah, Jean Claude N. Mbanya, K. M. Venkat Narayan, Ambady Ramachandran, Alisha N. Wade, Tomasz Zdrojewski, Mohsen Abbasi-Kangevari, Hanan F. Abdul Rahim, Niveen M. Abu-Rmeileh, Shalkar Adambekov, Robert J. Adams, Wichai Aekplakorn, Imelda A. Agdeppa, Javad Aghazadeh-Attari, Charles Agyemang, Ali Ahmadi, Naser Ahmadi, Nastaran Ahmadi, Soheir H. Ahmed, Kamel Ajlouni, Halima Al-Hinai, Badreya Al-Lahou, Jawad A. Al-Lawati, Deena Al Asfoor, Nawal M. Al Qaoud, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Maryam A. Aldwairji, Mohamed M. Ali, Farbod Alinezhad, Abdullah Alkandari, Husam F. Alomirah, Eman Aly, Deepak N. Amarapurkar, Lars Bo Andersen, Sigmund A. Anderssen, Dolores S. Andrade, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Tahir Aris, Nimmathota Arlappa, Krishna K. Aryal, Felix K. Assah, Batyrbek Assembekov, Juha Auvinen, Mária Avdičová, Kishwar Azad, Mohsen Azimi-Nezhad, Fereidoun Azizi, Flora Bacopoulou, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R. Banegas, Carlo M. Barbagallo, Alberto Barceló, Maja Baretić, Lena Barrera, Abdul Basit, Anwar M. Batieha, Aline P. Batista, Louise A. Baur, Antonisamy Belavendra, Habiba Ben Romdhane, Mikhail Benet, Salim Berkinbayev, Antonio Bernabe-Ortiz, Ximena Berrios Carrasola, Heloísa Bettiol, Augustin F. Beybey, Santosh K. Bhargava, Elysée Claude Bika Lele, Mukharram M. Bikbov, Bihungum Bista, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Björkelund, Katia V. Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Jose G. Boggia, Marialaura Bonaccio, Alice Bonilla-Vargas, Herman Borghs, Pascal Bovet, Imperia Brajkovich, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Yajaira Briceño, Miguel Brito, Anna Bugge, Frank Buntinx, Antonio Cabrera de León, Roberta B. Caixeta, Günay Can, Ana Paula C. Cândido, Mario V. Capanzana, Naděžda Čapková, Eduardo Capuano, Rocco Capuano, Vincenzo Capuano, Viviane C. Cardoso, Axel C. Carlsson, Felipe F. Casanueva, Laura Censi, Marvin Cervantes‐Loaiza, Parinya Chamnan, Snehalatha Chamukuttan, Queenie Chan, Fadi J. Charchar, Nish Chaturvedi, Huashuai Chen, Bahman Cheraghian, María-Dolores Chirlaque, Jerzy Chudek, Renata Cifkova, Massimo Cirillo, Frank Claessens, Emmanuel Cohen, Hans Concin, Cyrus Cooper, Simona Costanzo, Chris Cowell, Ana B. Crujeiras, Juan J. Cruz, Felipe V. Cureau, Sarah Cuschieri, Graziella D’Arrigo, Eleonora d’Orsi, Jean Dallongeville, Albertino Damasceno, Saeed Dastgiri, Amalia De Curtis, Giovanni de Gaetano, Stefaan De Henauw, Mohan Deepa, Vincent DeGennaro, Stefaan Demarest, Elaine Dennison, Valérie Deschamps, Meghnath Dhimal, Zivka Dika, Shirin Djalalinia, Chiara Donfrancesco, Guanghui Dong, Maria Dorobantu, Marcus Dörr, Nico Dragano, Wojciech Drygas, Yong Du, Charmaine A. Duante, Priscilla Duboz, Anar Dushpanova, Elzbieta Dziankowska-Zaborszczyk, Narges Ebrahimi, Ricky Eddie, Ebrahim Eftekhar, Vasiliki Efthymiou, Eruke E. Egbagbe, Sareh Eghtesad, Mohammad El-Khateeb, Jalila El Ati, Denise Eldemire-Shearer, Roberto Elosua, Ofem Enang, Rajiv T. Erasmus, Raimund Erbel, Cihangir Erem, Gul Ergor, Louise Eriksen, Johan G. Eriksson, Ali Esmaeili, Roger G. Evans, Ildar Fakhradiyev, Caroline H. Fall, Elnaz Faramarzi, Mojtaba Farjam, Yosef Farzi, Mohammad Reza Fattahi, Asher Fawwad, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernández-Bergés, Marika Ferrari, Catterina Ferreccio, Haroldo S. Ferreira, Eldridge Ferrer, Edith J. M. Feskens, David Flood, Maria Forsner, Sandrine Fosse, Edward F. Fottrell, Heba M. Fouad, Damian K. Francis, Guillermo Frontera, Takuro Furusawa, Zbigniew Gaciong, Sarah P. Garnett, Magda Gasull, Andrea Gazzinelli, Ulrike Gehring, Ebrahim Ghaderi, Seyyed-Hadi Ghamari, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Anup Ghimire, Alessandro Gialluisi, Simona Giampaoli, Francesco Gianfagna, Tiffany K. Gill, Glen Gironella, Aleksander Giwercman, David Goltzman, Aleksandra Gomula, Helen Gonçalves, Mauer Gonçalves, David A. Gonzalez-Chica, Marcela Gonzalez-Gross, Juan P. González-Rivas, María-Elena González-Villalpando, Angel R. Gonzalez, Frederic Gottrand, Dušan Grafnetter, Tomasz Grodzicki, Anders Grøntved, Ramiro Guerrero, Unjali P. Gujral, Rajeev Gupta, Laura Gutierrez, Xinyi Gwee, Rosa Haghshenas, Hamid Hakimi, Ian R. Hambleton, Behrooz Hamzeh, Willem A. Hanekom, Dominique Hange, Sari Hantunen, Jie Hao, Rachakulla Hari Kumar, Javad Harooni, Seyed Mohammad Hashemi-Shahri, Jun Hata, Christin Heidemann, Rafael dos Santos Henrique, Sauli Herrala, Karl-Heinz Herzig, Ramin Heshmat, Sai Yin Ho, Michelle Holdsworth, Reza Homayounfar, Wilma M. Hopman, Andrea R. V. R. Horimoto, Claudia Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, José María Huerta, Ilpo Tapani Huhtaniemi, Martijn Huisman, Abdullatif Husseini, Inge Huybrechts, Licia Iacoviello, Ellina M. Iakupova, Anna G. Iannone, Norazizah Ibrahim Wong, Chinwuba Ijoma, Vilma E. Irazola, Takafumi Ishida, Godsent C. Isiguzo, Sheikh Mohammed Shariful Islam, Duygu Islek, Till Ittermann, Masanori Iwasaki, Tuija Jääskeläinen, Jeremy M. Jacobs, Hashem Y. Jaddou, Michel Jadoul, Bakary Jallow, Kenneth James, Kazi M. Jamil, Edward Janus, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Anjani Kumar Jha, Ramon O. Jimenez, Karl-Heinz Jöckel, Jari J. Jokelainen, Jost B. Jonas, Pradeep Joshi, Josipa Josipović, Farahnaz Joukar, Jacek Jóźwiak, Anthony Kafatos, Eero O. Kajantie, Zhanna Kalmatayeva, Khem B. Karki, Marzieh Katibeh, Jussi Kauhanen, Gyulli M. Kazakbaeva, François F. Kaze, Calvin Ke, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Maryam Keramati, Mathilde Kersting, Yousef Saleh Khader, Arsalan Khaledifar, Davood Khalili, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ursula Kiechl-Kohlendorfer, Sophia J. Kiechl, Stefan Kiechl, Andrew Kingston, Heidi Klakk, Jana Klanova, Michael Knoflach, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Jelena Kos, Seppo Koskinen, Sudhir Kowlessur, Slawomir Koziel, Susi Kriemler, Peter Lund Kristensen, Daan Kromhout, Ruzena Kubinova, Urho M. Kujala, Mukhtar Kulimbet, Pawel Kurjata, Catherine Kyobutungi, Quang Ngoc La, Demetre Labadarios, Carl Lachat, Youcef Laid, Lachmie Lall, Tiina Lankila, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Martino Laurenzi, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Gabriel M. Leung, Yanping Li, M. Fernanda Lima-Costa, Hsien-Ho Lin, Lars Lind, Lauren Lissner, Xiaotian Liu, Esther Lopez-Garcia, Tania Lopez, José Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Michala Lustigová, George L. L. Machado-Coelho, Aristides M. Machado-Rodrigues, Enguerran Macia, Luisa M. Macieira, Ahmed A. Madar, Gladys E. Maestre, Stefania Maggi, Dianna J. Magliano, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marcia Makdisse, Mohammad-Reza Malekpour, Fatemeh Malekzadeh, Reza Malekzadeh, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Lynell V. Maniego, Yannis Manios, Masimango Imani Mannix, Fariborz Mansour-Ghanaei, Enzo Manzato, Paula Margozzini, Joany Mariño, Larissa Pruner Marques, Reynaldo Martorell, Luis P. Mascarenhas, Masoud Masinaei, Ellisiv B. Mathiesen, Tandi E. Matsha, Anselmo J. Mc Donald Posso, Shelly R. McFarlane, Stephen T. McGarvey, Sounnia Mediene Benchekor, Kirsten Mehlig, Amir Houshang Mehrparvar, Jesus D. Melgarejo, Fabián Méndez, Ana Maria B. Menezes, Alibek Mereke, Indrapal I. Meshram, Diane T. Meto, Cláudia S. Minderico, G. K. Mini, Juan Francisco Miquel, J. Jaime Miranda, Mohammad Reza Mirjalili, Pietro A. Modesti, Sahar Saeedi Moghaddam, Mostafa K. Mohamed, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Niels C. Møller, Dénes Molnár, Amirabbas Momenan, Charles K. Mondo, Roger A. Montenegro Mendoza, Eric Monterrubio-Flores, Mahmood Moosazadeh, Farhad Moradpour, Alain Morejon, Luis A. Moreno, Karen Morgan, Suzanne N. Morin, Alireza Moslem, Mildrey Mosquera, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Mohammad Esmaeel Motlagh, Jorge Motta, Kelias P. Msyamboza, Thet Thet Mu, Maria L. Muiesan, Jaakko Mursu, Kamarul Imran Musa, Norlaila Mustafa, Muel Telo M. C. Muyer, Iraj Nabipour, Gabriele Nagel, Balkish M. Naidu, Farid Najafi, Jana Námešná, Vinay B. Nangia, Take Naseri, Nareemarn Neelapaichit, Azim Nejatizadeh, Ilona Nenko, Flavio Nervi, Tze Pin Ng, Chung T. Nguyen, Quang Ngoc Nguyen, Michael Y. Ni, Peng Nie, Ramfis E. Nieto-Martínez, Toshiharu Ninomiya, Marianna Noale, Oscar A. Noboa, Davide Noto, Mohannad Al Nsour, Irfan Nuhoğlu, Terence W. O’Neill, Augustine N. Odili, Kyungwon Oh, Ryutaro Ohtsuka, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Obinna Onodugo, Pedro Ordunez, Rui Ornelas, Pedro J. Ortiz, Clive Osmond, Afshin Ostovar, Johanna A. Otero, Charlotte B. Ottendahl, Akaninyene Otu, Ellis Owusu-Dabo, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Mariela Paoli, Suyeon Park, Mahboubeh Parsaeian, Nikhil D. Patel, Raimund Pechlaner, Ivan Pećin, João M. Pedro, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Thaliane Mayara Pessôa dos Prazeres, Niloofar Peykari, Modou Cheyassin Phall, Son Thai Pham, Hiep Hoang Phan, Rafael N. Pichardo, Hynek Pikhart, Aida Pilav, Pavel Piler, Freda Pitakaka, Aleksandra Piwonska, Andreia N. Pizarro, Pedro Plans-Rubió, Silvia Plata, Miquel Porta, Anil Poudyal, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Rui Providencia, Jardena J. Puder, Solie Puhakka, Margus Punab, Mostafa Qorbani, Hedley K. Quintana, Tran Quoc Bao, Salar Rahimikazerooni, Olli Raitakari, Manuel Ramirez-Zea, Jacqueline Ramke, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Daniel A. Rangel Reina, Mohammad-Mahdi Rashidi, Josep Redon, Jane D. P. Renner, Cézane P. Reuter, Luis Revilla, Negar Rezaei, Abbas Rezaianzadeh, Fernando Rigo, Reina G. Roa, Louise Robinson, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A. Rodríguez-Villamizar, Andrea Y. Rodríguez, Ulla Roggenbuck, Peter Rohloff, Elisabetta L. Romeo, Annika Rosengren, Adolfo Rubinstein, Petra Rust, Marcin Rutkowski, Hamideh Sabbaghi, Harshpal S. Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Sare Safi, Saeid Safiri, Mohammad Hossien Saghi, Olfa Saidi, Nader Saki, Sanja Šalaj, Benoit Salanave, Jukka T. Salonen, Massimo Salvetti, Jose Sánchez-Abanto, Diana A. Santos, Lèlita C. Santos, Maria Paula Santos, Tamara R. Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Mariana Sbaraini, Marcia Scazufca, Beatriz D. Schaan, Christa Scheidt-Nave, Sabine Schipf, Carsten O. Schmidt, Ben Schöttker, Sara Schramm, Sylvain Sebert, Moslem Sedaghattalab, Aye Aye Sein, Sadaf G. Sepanlou, Ronel Sewpaul, Teresa Shamah-Levy, Seyed Morteza Shamshirgaran, Maryam Sharafkhah, Sanjib K. Sharma, Almaz Sharman, Amaneh Shayanrad, Ali Akbar Shayesteh, Hana Shimizu-Furusawa, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjöström, Jolanta Slowikowska-Hilczer, Przemysław Slusarczyk, Liam Smeeth, Eugène Sobngwi, Stefan Söderberg, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Aïcha Soumaré, Alfonso Sousa-Poza, Karen Sparrenberger, Jan A. Staessen, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, Jochanan Stessman, Jakub Stokwiszewski, Karien Stronks, Milton F. Suarez-Ortegón, Phalakorn Suebsamran, Johan Sundström, Paibul Suriyawongpaisal, René Charles Sylva, Moyses Szklo, Abdonas Tamosiunas, Mohammed Rasoul Tarawneh, Carolina B. Tarqui-Mamani, Anne Taylor, Julie Taylor, Tania Tello, K. R. Thankappan, Holger Theobald, Xenophon Theodoridis, Nihal Thomas, Amanda G. Thrift, Erik J. Timmermans, Dwi Hapsari Tjandrarini, Hanna K. Tolonen, Janne S. Tolstrup, Maciej Tomaszewski, Murat Topbas, Laura Torres-Collado, Pierre Traissac, Areti Triantafyllou, John Tuitele, Azaliia M. Tuliakova, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Evangelia Tzala, Christophe Tzourio, Peter Ueda, Eunice Ugel, Flora A. M. Ukoli, Hanno Ulmer, Hannu M. T. Uusitalo, Gonzalo Valdivia, Bert-Jan van den Born, Johan Van der Heyden, Hoang Van Minh, Lenie van Rossem, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Elisabeth M. van Zutphen, Dirk Vanderschueren, Diego Vanuzzo, Senthil K. Vasan, Tomas Vega, Gustavo Velasquez-Melendez, Roosmarijn Verstraeten, Lucie Viet, Salvador Villalpando, Jesus Vioque, Jyrki K. Virtanen, Bharathi Viswanathan, Ari Voutilainen, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Chongjian Wang, Ningli Wang, Qian Wang, Ya Xing Wang, Ying-Wei Wang, S. Goya Wannamethee, Karen Webster-Kerr, Niels Wedderkopp, Wenbin Wei, Leo D. Westbury, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Więcek, Rainford J. Wilks, Johann Willeit, Peter Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Andrew Wong, Emily B. Wong, Mark Woodward, Frederick C. Wu, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Li Yan, Weili Yan, Moein Yoosefi, Akihiro Yoshihara, Novie O. Younger-Coleman, Yu-Ling Yu, Yunjiang Yu, Ahmad Faudzi Yusoff, Ahmad A. Zainuddin, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Ko Ko Zaw, Tajana Zeljkovic Vrkic, Yi Zeng, Zhen-Yu Zhang, Bekbolat Zholdin, Paul Zimmet, Emanuel Zitt, Nada Zoghlami, Julio Zuñiga Cisneros, Majid Ezzati

Nature Medicine 2023.11

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Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.

DOI： 10.1038/s41591-023-02610-2

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Other Link： https://www.nature.com/articles/s41591-023-02610-2
Associations between Plasma Antibody Levels against Porphyromonas gingivalis and Atrial Fibrillation among Community-Dwelling Older Individuals in Japan: A Cross-Sectional Study. Reviewed International journal

Takashi Hoshino, Noboru Kaneko, Akihiro Yoshihara, Masanori Iwasaki, Kana Suwama, Yumi Ito, Junta Tanaka, Ichiei Narita, Hiroshi Ogawa

Oral health & preventive dentistry 21 ( 1 ) 339 - 346 2023.9

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Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To investigate the association between plasma antibody levels against Porphyromonas gingivalis (PG) and atrial fibrillation (AF) history in community-dwelling older individuals in Japan. MATERIALS AND METHODS: This study was a subset of the Uonuma cohort study, including 3091 participants aged 60-79 years. Data were collected, including AF history as a dependent variable, plasma immunoglobulin G antibody levels against PG as an independent variable, and previously reported AF risk factors and demographic information as covariates. RESULTS: The median age of the participants was 69 years. Of the 3091 participants, 1411 (45.6%) were men, and 56 (1.8%) had an AF history. AF prevalence was significantly higher in participants with higher antibody levels against PG than in those with lower antibody levels (3.0% vs 1.4%; p = 0.005). Multivariable logistic regression analysis showed that participants with higher antibody levels against PG had twofold higher odds of having AF (odds ratio = 2.13; 95% confidence interval = 1.23-3.69). Restricted cubic spline analysis indicated a nonlinear relationship between antibody levels against PG and AF history. CONCLUSION: Plasma antibody levels against PG were associated with AF history in community-dwelling older individuals in Japan.

DOI： 10.3290/j.ohpd.b4528813

PubMed

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Changes in oral health status with dental intervention during the acute to subacute stages of stroke. Reviewed International journal

Ayu Sakai, Koichiro Matsuo, Yu Sekimoto, Rena Hidaka, Akihiro Yoshihara

Gerodontology 2023.7

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Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To investigate the changes in oral health status with dental intervention during the acute and subacute stages of stroke and their associations with oral intake status. BACKGROUND: Oral health may deteriorate easily in patients following a stroke. However, data are scarce on the changes in oral health with dental intervention throughout the acute and subacute stages of stroke recovery. MATERIAL AND METHODS: We prospectively recruited 98 stroke patients who were admitted to an acute hospital and referred to a dental team and then could be followed at a subacute rehabilitation unit in the same hospital. Provided dental intervention, including oral health care and other general dental treatments, was recorded. Oral health was assessed with Oral Health Assessment Tool (OHAT), and the changes in OHAT score during the acute and subacute stages were statistically tested. Oral feeding status was examined using Functional Oral Intake Scale (FOIS). The cohort was divided into the non-oral feeding, dysphagia and regular diet groups based on FOIS score. Differences in OHAT among the oral intake groups were statistically tested. RESULTS: Gross OHAT score did not differ among the oral intake groups at the time of admission (mean ± standard deviation score: 6.5 ± 2.8 for non-oral diet, 5.6 ± 2.4 for dysphagia diet and 5.3 ± 2.1 for regular diet), but improved more in the regular diet group (2.4 ± 1.5) than in the other groups (5.8 ± 3.0 for non-oral diet and 4.0 ± 2.1 for dysphagia diet) at the last evaluation. Oral hygiene scores improved significantly in the acute stage, while scores for dentures and natural teeth ameliorated significantly in the subacute stage. CONCLUSION: Our findings suggest that appropriate dental intervention in the acute and subacute stages of stroke may contribute to improved oral health and oral food intake.

DOI： 10.1111/ger.12706

PubMed

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アルコール摂取状況と歯の喪失との関連についての研究魚沼コホート研究ベースライン調査 Reviewed

諏訪間加奈, 岩崎正則, 伊藤由美, 葭原明弘

口腔衛生学会雑誌 73 ( 3 ) 177 - 184 2023.7

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Language：Japanese Publisher：(一社)日本口腔衛生学会

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00440&link_issn=&doc_id=20230814210002&doc_link_id=%2Fdk1dehea%2F2023%2F007303%2F002%2F0177-0184%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2023%2F007303%2F002%2F0177-0184%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Diminishing benefits of urban living for children and adolescents’ growth and development Reviewed

Anu Mishra, Bin Zhou, Andrea Rodriguez-Martinez, Honor Bixby, Rosie K. Singleton, Rodrigo M. Carrillo-Larco, Kate E. Sheffer, Christopher J. Paciorek, James E. Bennett, Victor Lhoste, Maria L. C. Iurilli, Mariachiara Di Cesare, James Bentham, Nowell H. Phelps, Marisa K. Sophiea, Gretchen A. Stevens, Goodarz Danaei, Melanie J. Cowan, Stefan Savin, Leanne M. Riley, Edward W. Gregg, Wichai Aekplakorn, Noor Ani Ahmad, Jennifer L. Baker, Adela Chirita-Emandi, Farshad Farzadfar, Günther Fink, Mirjam Heinen, Nayu Ikeda, Andre P. Kengne, Young-Ho Khang, Tiina Laatikainen, Avula Laxmaiah, Jun Ma, Michele Monroy-Valle, Malay K. Mridha, Cristina P. Padez, Andrew Reynolds, Maroje Sorić, Gregor Starc, James P. Wirth, Leandra Abarca-Gómez, Ziad A. Abdeen, Shynar Abdrakhmanova, Suhaila Abdul Ghaffar, Hanan F. Abdul Rahim, Zulfiya Abdurrahmonova, Niveen M. Abu-Rmeileh, Jamila Abubakar Garba, Benjamin Acosta-Cazares, Ishag Adam, Marzena Adamczyk, Robert J. Adams, Seth Adu-Afarwuah, Kaosar Afsana, Shoaib Afzal, Valirie N. Agbor, Imelda A. Agdeppa, Javad Aghazadeh-Attari, Hassan Aguenaou, Carlos A. Aguilar-Salinas, Charles Agyemang, Mohamad Hasnan Ahmad, Ali Ahmadi, Naser Ahmadi, Nastaran Ahmadi, Imran Ahmed, Soheir H. Ahmed, Wolfgang Ahrens, Gulmira Aitmurzaeva, Kamel Ajlouni, Hazzaa M. Al-Hazzaa, Badreya Al-Lahou, Rajaa Al-Raddadi, Huda M. Al Hourani, Nawal M. Al Qaoud, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Maryam A. Aldwairji, Sylvia Alexius, Mohamed M. Ali, Abdullah Alkandari, Ala’a Alkerwi, Buthaina M. Alkhatib, Kristine Allin, Mar Alvarez-Pedrerol, Eman Aly, Deepak N. Amarapurkar, Pilar Amiano Etxezarreta, John Amoah, Norbert Amougou, Philippe Amouyel, Lars Bo Andersen, Sigmund A. Anderssen, Odysseas Androutsos, Lars Ängquist, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Elena Anufrieva, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E. Arku, Nimmathota Arlappa, Krishna K. Aryal, Nega Aseffa, Thor Aspelund, Felix K. Assah, Batyrbek Assembekov, Maria Cecília F. Assunção, May Soe Aung, Juha Auvinen, Mária Avdičová, Shina Avi, Ana Azevedo, Mohsen Azimi-Nezhad, Fereidoun Azizi, Mehrdad Azmin, Bontha V. Babu, Maja Bæksgaard Jørgensen, Azli Baharudin, Suhad Bahijri, Marta Bakacs, Nagalla Balakrishna, Yulia Balanova, Mohamed Bamoshmoosh, Maciej Banach, José R. Banegas, Joanna Baran, Rafał Baran, Carlo M. Barbagallo, Valter Barbosa Filho, Alberto Barceló, Maja Baretić, Amina Barkat, Joaquin Barnoya, Lena Barrera, Marta Barreto, Aluisio J. D. Barros, Mauro Virgílio Gomes Barros, Anna Bartosiewicz, Abdul Basit, Joao Luiz D. Bastos, Iqbal Bata, Anwar M. Batieha, Aline P. Batista, Rosangela L. Batista, Zhamilya Battakova, Louise A. Baur, Pascal M. Bayauli, Robert Beaglehole, Silvia Bel-Serrat, Antonisamy Belavendra, Habiba Ben Romdhane, Judith Benedics, Mikhail Benet, Gilda Estela Benitez Rolandi, Elling Bere, Ingunn Holden Bergh, Yemane Berhane, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Ximena Berrios Carrasola, Heloísa Bettiol, Manfred E. Beutel, Augustin F. Beybey, Jorge Bezerra, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K. Bhargava, Hongsheng Bi, Yufang Bi, Daniel Bia, Katia Biasch, Elysée Claude Bika Lele, Mukharram M. Bikbov, Bihungum Bista, Dusko J. Bjelica, Anne A. Bjerregaard, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Björkelund, Katia V. Bloch, Anneke Blokstra, Moran Blychfeld Magnazu, Simona Bo, Martin Bobak, Lynne M. Boddy, Bernhard O. Boehm, Jolanda M. A. Boer, Jose G. Boggia, Elena Bogova, Carlos P. Boissonnet, Stig E. Bojesen, Marialaura Bonaccio, Vanina Bongard, Alice Bonilla-Vargas, Matthias Bopp, Herman Borghs, Pascal Bovet, Khadichamo Boymatova, Lien Braeckevelt, Lutgart Braeckman, Marjolijn C. E. Bragt, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, João Breda, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Yajaira Briceño, Lacramioara Brinduse, Miguel Brito, Sinead Brophy, Johannes Brug, Graziella Bruno, Anna Bugge, Frank Buntinx, Marta Buoncristiano, Genc Burazeri, Con Burns, Antonio Cabrera de León, Joseph Cacciottolo, Hui Cai, Roberta B. Caixeta, Tilema Cama, Christine Cameron, José Camolas, Günay Can, Ana Paula C. Cândido, Felicia Cañete, Mario V. Capanzana, Naděžda Čapková, Eduardo Capuano, Rocco Capuano, Vincenzo Capuano, Marloes Cardol, Viviane C. Cardoso, Axel C. Carlsson, Esteban Carmuega, Joana Carvalho, José A. Casajús, Felipe F. Casanueva, Maribel Casas, Ertugrul Celikcan, Laura Censi, Marvin Cervantes‐Loaiza, Juraci A. Cesar, Snehalatha Chamukuttan, Angelique Chan, Queenie Chan, Himanshu K. Chaturvedi, Nish Chaturvedi, Norsyamlina Che Abdul Rahim, Miao Li Chee, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Yiling J. Cheng, Bahman Cheraghian, Angela Chetrit, Ekaterina Chikova-Iscener, Mai J. M. Chinapaw, Anne Chinnock, Arnaud Chiolero, Shu-Ti Chiou, María-Dolores Chirlaque, Belong Cho, Kaare Christensen, Diego G. Christofaro, Jerzy Chudek, Renata Cifkova, Michelle Cilia, Eliza Cinteza, Massimo Cirillo, Frank Claessens, Janine Clarke, Els Clays, Emmanuel Cohen, Laura-María Compañ-Gabucio, Hans Concin, Susana C. Confortin, Cyrus Cooper, Tara C. Coppinger, Eva Corpeleijn, Lilia Yadira Cortés, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L. Craig, Amelia C. Crampin, Amanda J. Cross, Ana B. Crujeiras, Juan J. Cruz, Tamás Csányi, Semánová Csilla, Alexandra M. Cucu, Liufu Cui, Felipe V. Cureau, Sarah Cuschieri, Ewelina Czenczek-Lewandowska, Graziella D’Arrigo, Eleonora d’Orsi, Liliana Dacica, Jean Dallongeville, Albertino Damasceno, Camilla T. Damsgaard, Rachel Dankner, Thomas M. Dantoft, Parasmani Dasgupta, Saeed Dastgiri, Luc Dauchet, Kairat Davletov, Maria Alice Altenburg de Assis, Guy De Backer, Dirk De Bacquer, Amalia De Curtis, Patrícia de Fragas Hinnig, Giovanni de Gaetano, Stefaan De Henauw, Pilar De Miguel-Etayo, Paula Duarte de Oliveira, David De Ridder, Karin De Ridder, Susanne R. de Rooij, Delphine De Smedt, Mohan Deepa, Alexander D. Deev, Vincent DeGennaro, Hélène Delisle, Francis Delpeuch, Stefaan Demarest, Elaine Dennison, Katarzyna Dereń, Valérie Deschamps, Meghnath Dhimal, Augusto Di Castelnuovo, Juvenal Soares Dias-da-Costa, María Elena Díaz-Sánchez, Alejandro Diaz, Pedro Díaz Fernández, María Pilar Díez Ripollés, Zivka Dika, Shirin Djalalinia, Visnja Djordjic, Ha T. P. Do, Annette J. Dobson, Liria Dominguez, Maria Benedetta Donati, Chiara Donfrancesco, Guanghui Dong, Yanhui Dong, Silvana P. Donoso, Angela Döring, Maria Dorobantu, Ahmad Reza Dorosty, Kouamelan Doua, Nico Dragano, Wojciech Drygas, Jia Li Duan, Charmaine A. Duante, Priscilla Duboz, Vesselka L. Duleva, Virginija Dulskiene, Samuel C. Dumith, Anar Dushpanova, Azhar Dyussupova, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Guadalupe Echeverría, Ricky Eddie, Ebrahim Eftekhar, Eruke E. Egbagbe, Robert Eggertsen, Sareh Eghtesad, Gabriele Eiben, Ulf Ekelund, Mohammad El-Khateeb, Laila El Ammari, Jalila El Ati, Denise Eldemire-Shearer, Marie Eliasen, Paul Elliott, Ronit Endevelt, Reina Engle-Stone, Rajiv T. Erasmus, Raimund Erbel, Cihangir Erem, Gul Ergor, Louise Eriksen, Johan G. Eriksson, Jorge Escobedo-de la Peña, Saeid Eslami, Ali Esmaeili, Alun Evans, David Faeh, Ildar Fakhradiyev, Albina A. Fakhretdinova, Caroline H. Fall, Elnaz Faramarzi, Mojtaba Farjam, Victoria Farrugia Sant’Angelo, Mohammad Reza Fattahi, Asher Fawwad, Wafaie W. Fawzi, Edit Feigl, Francisco J. Felix-Redondo, Trevor S. Ferguson, Romulo A. Fernandes, Daniel Fernández-Bergés, Daniel Ferrante, Thomas Ferrao, Gerson Ferrari, Marika Ferrari, Marco M. Ferrario, Catterina Ferreccio, Haroldo S. Ferreira, Eldridge Ferrer, Jean Ferrieres, Thamara Hubler Figueiró, Anna Fijalkowska, Mauro Fisberg, Krista Fischer, Leng Huat Foo, Maria Forsner, Heba M. Fouad, Damian K. Francis, Maria do Carmo Franco, Zlatko Fras, Guillermo Frontera, Flavio D. Fuchs, Sandra C. Fuchs, Isti I. Fujiati, Yuki Fujita, Matsuda Fumihiko, Viktoriya Furdela, Takuro Furusawa, Zbigniew Gaciong, Mihai Gafencu, Manuel Galán Cuesta, Andrzej Galbarczyk, Henrike Galenkamp, Daniela Galeone, Myriam Galfo, Fabio Galvano, Jingli Gao, Pei Gao, Manoli Garcia-de-la-Hera, María José García Mérida, Marta García Solano, Dickman Gareta, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Adroaldo Cesar Araujo Gaya, Anelise Reis Gaya, Andrea Gazzinelli, Ulrike Gehring, Harald Geiger, Johanna M. Geleijnse, Ronnie George, Ebrahim Ghaderi, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Alessandro Gialluisi, Simona Giampaoli, Francesco Gianfagna, Christian Gieger, Tiffany K. Gill, Jonathan Giovannelli, Glen Gironella, Aleksander Giwercman, Konstantinos Gkiouras, Natalya Glushkova, Natalja Gluškova, Ramesh Godara, Justyna Godos, Sibel Gogen, Marcel Goldberg, David Goltzman, Georgina Gómez, Jesús Humberto Gómez Gómez, Luis F. Gomez, Santiago F. Gómez, Aleksandra Gomula, Bruna Gonçalves Cordeiro da Silva, Helen Gonçalves, Mauer Gonçalves, Ana D. González-Alvarez, David A. Gonzalez-Chica, Esther M. González-Gil, Marcela Gonzalez-Gross, Margot González-Leon, Juan P. González-Rivas, Clicerio González-Villalpando, María-Elena González-Villalpando, Angel R. Gonzalez, Frederic Gottrand, Antonio Pedro Graça, Sidsel Graff-Iversen, Dušan Grafnetter, Aneta Grajda, Maria G. Grammatikopoulou, Ronald D. Gregor, Maria João Gregório, Else Karin Grøholt, Anders Grøntved, Giuseppe Grosso, Gabriella Gruden, Dongfeng Gu, Viviana Guajardo, Emanuela Gualdi-Russo, Pilar Guallar-Castillón, Andrea Gualtieri, Elias F. Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L. Guimaraes, Martin C. Gulliford, Johanna Gunnlaugsdottir, Marc J. Gunter, Xiu-Hua Guo, Yin Guo, Prakash C. Gupta, Rajeev Gupta, Oye Gureje, Enrique Gutiérrez González, Laura Gutierrez, Felix Gutzwiller, Xinyi Gwee, Seongjun Ha, Farzad Hadaegh, Charalambos A. Hadjigeorgiou, Rosa Haghshenas, Hamid Hakimi, Jytte Halkjær, Ian R. Hambleton, Behrooz Hamzeh, Willem A. Hanekom, Dominique Hange, Abu A. M. Hanif, Sari Hantunen, Jie Hao, Carla Menêses Hardman, Rachakulla Hari Kumar, Tina Harmer Lassen, Javad Harooni, Seyed Mohammad Hashemi-Shahri, Maria Hassapidou, Jun Hata, Teresa Haugsgjerd, Alison J. Hayes, Jiang He, Yuan He, Yuna He, Regina Heidinger-Felső, Margit Heier, Tatjana Hejgaard, Marleen Elisabeth Hendriks, Rafael dos Santos Henrique, Ana Henriques, Leticia Hernandez Cadena, Sauli Herrala, Marianella Herrera-Cuenca, Victor M. Herrera, Isabelle Herter-Aeberli, Karl-Heinz Herzig, Ramin Heshmat, Allan G. Hill, Sai Yin Ho, Suzanne C. Ho, Michael Hobbs, Doroteia A. Höfelmann, Michelle Holdsworth, Reza Homayounfar, Clara Homs, Wilma M. Hopman, Andrea R. V. R. Horimoto, Claudia M. Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Ilpo Tapani Huhtaniemi, Laetitia Huiart, Constanta Huidumac Petrescu, Martijn Huisman, Abdullatif Husseini, Chinh Nguyen Huu, Inge Huybrechts, Nahla Hwalla, Jolanda Hyska, Licia Iacoviello, Ellina M. Iakupova, Jesús M. Ibarluzea, Mohsen M. Ibrahim, Norazizah Ibrahim Wong, M. Arfan Ikram, Carmen Iñiguez, Violeta Iotova, Vilma E. Irazola, Takafumi Ishida, Godsent C. Isiguzo, Muhammad Islam, Sheikh Mohammed Shariful Islam, Duygu Islek, Ivaila Y. Ivanova-Pandourska, Masanori Iwasaki, Tuija Jääskeläinen, Rod T. Jackson, Jeremy M. Jacobs, Michel Jadoul, Tazeen Jafar, Bakary Jallow, Kenneth James, Kazi M. Jamil, Konrad Jamrozik, Anna Jansson, Imre Janszky, Edward Janus, Juel Jarani, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Chao Qiang Jiang, Ramon O. Jimenez, Karl-Heinz Jöckel, Michel Joffres, Jari J. Jokelainen, Jost B. Jonas, Jitendra Jonnagaddala, Torben Jørgensen, Pradeep Joshi, Josipa Josipović, Farahnaz Joukar, Jacek J. Jóźwiak, Debra S. Judge, Anne Juolevi, Gregor Jurak, Iulia Jurca Simina, Vesna Juresa, Rudolf Kaaks, Felix O. Kaducu, Anthony Kafatos, Mónika Kaj, Eero O. Kajantie, Natia Kakutia, Daniela Kállayová, Zhanna Kalmatayeva, Ofra Kalter-Leibovici, Yves Kameli, Freja B. Kampmann, Kodanda R. Kanala, Srinivasan Kannan, Efthymios Kapantais, Eva Karaglani, Argyro Karakosta, Line L. Kårhus, Khem B. Karki, Philippe B. Katchunga, Marzieh Katibeh, Joanne Katz, Peter T. Katzmarzyk, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli M. Kazakbaeva, François F. Kaze, Calvin Ke, Ulrich Keil, Lital Keinan Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Cecily Kelleher, Han C. G. Kemper, Maryam Keramati, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Arsalan Khaledifar, Davood Khalili, Kay-Tee Khaw, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ilse M. S. L. Khouw, Ursula Kiechl-Kohlendorfer, Sophia J. Kiechl, Stefan Kiechl, Japhet Killewo, Hyeon Chang Kim, Jeongseon Kim, Jenny M. Kindblom, Andrew Kingston, Heidi Klakk, Magdalena Klimek, Jeannette Klimont, Jurate Klumbiene, Michael Knoflach, Bhawesh Koirala, Elin Kolle, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Magdalena Korzycka, Jelena Kos, Seppo Koskinen, Katsuyasu Kouda, Éva Kovács, Viktoria Anna Kovacs, Irina Kovalskys, Sudhir Kowlessur, Slawomir Koziel, Jana Kratenova, Wolfgang Kratzer, Vilma Kriaucioniene, Susi Kriemler, Peter Lund Kristensen, Helena Krizan, Maria F. Kroker-Lobos, Steinar Krokstad, Daan Kromhout, Herculina S. Kruger, Ruan Kruger, Łukasz Kryst, Ruzena Kubinova, Renata Kuciene, Urho M. Kujala, Enisa Kujundzic, Zbigniew Kulaga, Mukhtar Kulimbet, R. Krishna Kumar, Marie Kunešová, Pawel Kurjata, Yadlapalli S. Kusuma, Vladimir Kutsenko, Kari Kuulasmaa, Catherine Kyobutungi, Quang Ngoc La, Fatima Zahra Laamiri, Carl Lachat, Karl J. Lackner, Youcef Laid, Lachmie Lall, Tai Hing Lam, Maritza Landaeta Jimenez, Edwige Landais, Vera Lanska, Georg Lappas, Bagher Larijani, Simo Pone Larissa, Tint Swe Latt, Martino Laurenzi, Laura Lauria, Maria Lazo-Porras, Gwenaëlle Le Coroller, Khanh Le Nguyen Bao, Agnès Le Port, Tuyen D. Le, Jeannette Lee, Jeonghee Lee, Paul H. Lee, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Branimir Leskošek, Justyna Leszczak, Katja B. Leth-Møller, Gabriel M. Leung, Naomi S. Levitt, Yanping Li, Merike Liivak, Christa L. Lilly, Charlie Lim, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Yi-Ting Lin, Lars Lind, Vijaya Lingam, Birgit Linkohr, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Jing Liu, Lijuan Liu, Wei-Cheng Lo, Helle-Mai Loit, Khuong Quynh Long, Guadalupe Longo Abril, Luis Lopes, Marcus V. V. Lopes, Oscar Lopes, Esther Lopez-Garcia, Tania Lopez, Paulo A. Lotufo, José Eugenio Lozano, Janice L. Lukrafka, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Charles Lunogelo, Michala Lustigová, Edyta Łuszczki, Jean-René M’Buyamba-Kabangu, Guansheng Ma, Xu Ma, George L. L. Machado-Coelho, Aristides M. Machado-Rodrigues, Enguerran Macia, Luisa M. Macieira, Ahmed A. Madar, Anja L. Madsen, Gladys E. Maestre, Stefania Maggi, Dianna J. Magliano, Sara Magnacca, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marjeta Majer, Marcia Makdisse, Päivi Mäki, Fatemeh Malekzadeh, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia K. Malyutina, Lynell V. Maniego, Yannis Manios, Masimango Imani Manix, Jim I. Mann, Fariborz Mansour-Ghanaei, Taru Manyanga, Enzo Manzato, Anie Marcil, Paula Margozzini, Joany Mariño, Anastasia Markaki, Oonagh Markey, Eliza Markidou Ioannidou, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Yves Martin-Prevel, Rosemarie Martin, Reynaldo Martorell, Eva Martos, Katharina Maruszczak, Stefano Marventano, Giovanna Masala, Luis P. Mascarenhas, Shariq R. Masoodi, Ellisiv B. Mathiesen, Prashant Mathur, Alicia Matijasevich, Piotr Matłosz, Tandi E. Matsha, Victor Matsudo, Christina Mavrogianni, Artur Mazur, Jean Claude N. Mbanya, Shelly R. McFarlane, Stephen T. McGarvey, Martin McKee, Stela McLachlan, Rachael M. McLean, Scott B. McLean, Margaret L. McNairy, Breige A. McNulty, Sounnia Mediene Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Jørgen Meisfjord, Christa Meisinger, Jesus D. Melgarejo, Marina Melkumova, João Mello, Fabián Méndez, Carlos O. Mendivil, Ana Maria B. Menezes, Geetha R. Menon, Gert B. M. Mensink, Maria Teresa Menzano, Indrapal I. Meshram, Diane T. Meto, Jie Mi, Kim F. Michaelsen, Nathalie Michels, Kairit Mikkel, Karolina Miłkowska, Jody C. Miller, Olga Milushkina, Cláudia S. Minderico, G. K. Mini, Juan Francisco Miquel, J. Jaime Miranda, Mohammad Reza Mirjalili, Daphne Mirkopoulou, Erkin Mirrakhimov, Marjeta Mišigoj-Duraković, Antonio Mistretta, Veronica Mocanu, Pietro A. Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K. Mohamed, Shukri F. Mohamed, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Farnam Mohebi, Marie Moitry, Line T. Møllehave, Niels C. Møller, Dénes Molnár, Amirabbas Momenan, Charles K. Mondo, Roger A. Montenegro Mendoza, Eric Monterrubio-Flores, Kotsedi Daniel K. Monyeki, Jin Soo Moon, Mahmood Moosazadeh, Hermine T. Mopa, Farhad Moradpour, Leila B. Moreira, Alain Morejon, Luis A. Moreno, Francis Morey, Karen Morgan, Suzanne N. Morin, Erik Lykke Mortensen, George Moschonis, Alireza Moslem, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Anabela Mota-Pinto, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Marcos André Moura-dos-Santos, Yeva Movsesyan, Kelias P. Msyamboza, Thet Thet Mu, Magdalena Muc, Florian Muca, Boban Mugoša, Maria L. Muiesan, Martina Müller-Nurasyid, Thomas Münzel, Jaakko Mursu, Elaine M. Murtagh, Kamarul Imran Musa, Sanja Musić Milanović, Vera Musil, Geofrey Musinguzi, Muel Telo M. C. Muyer, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Farid Najafi, Harunobu Nakamura, Hanna Nalecz, Jana Námešná, Ei Ei K. Nang, Vinay B. Nangia, Martin Nankap, Sameer Narake, Paola Nardone, Take Naseri, Matthias Nauck, William A. Neal, Azim Nejatizadeh, Chandini Nekkantti, Keiu Nelis, Ilona Nenko, Martin Neovius, Flavio Nervi, Tze Pin Ng, Chung T. Nguyen, Nguyen D. Nguyen, Quang Ngoc Nguyen, Michael Y. Ni, Rodica Nicolescu, Peng Nie, Ramfis E. Nieto-Martínez, Yury P. Nikitin, Guang Ning, Toshiharu Ninomiya, Nobuo Nishi, Sania Nishtar, Marianna Noale, Oscar A. Noboa, Helena Nogueira, Maria Nordendahl, Børge G. Nordestgaard, Davide Noto, Natalia Nowak-Szczepanska, Mohannad Al Nsour, Irfan Nuhoğlu, Baltazar Nunes, Eha Nurk, Fred Nuwaha, Moffat Nyirenda, Terence W. O’Neill, Dermot O’Reilly, Galina Obreja, Caleb Ochimana, Angélica M. Ochoa-Avilés, Eiji Oda, Augustine N. Odili, Kyungwon Oh, Kumiko Ohara, Claes Ohlsson, Ryutaro Ohtsuka, Örn Olafsson, Maria Teresa A. Olinto, Isabel O. Oliveira, Mohd Azahadi Omar, Saeed M. Omar, Altan Onat, Sok King Ong, N. Charlotte Onland-Moret, Lariane M. Ono, Pedro Ordunez, Rui Ornelas, Ana P. Ortiz, Pedro J. Ortiz, Merete Osler, Clive Osmond, Sergej M. Ostojic, Afshin Ostovar, Johanna A. Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Ioannis Pagkalos, Elena Pahomova, Karina Mary de Paiva, Andrzej Pająk, Alberto Palloni, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Arvind Pandey, Francesco Panza, Mariela Paoli, Sousana K. Papadopoulou, Dimitrios Papandreou, Rossina G. Pareja, Soon-Woo Park, Suyeon Park, Winsome R. Parnell, Mahboubeh Parsaeian, Ionela M. Pascanu, Patrick Pasquet, Nikhil D. Patel, Marcos Pattussi, Halyna Pavlyshyn, Raimund Pechlaner, Ivan Pećin, Mangesh S. Pednekar, João M. Pedro, Nasheeta Peer, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Marco A. Peres, Cynthia M. Pérez, Valentina Peterkova, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Ausra Petrauskiene, Olga Petrovna Kovtun, Emanuela Pettenuzzo, Niloofar Peykari, Norbert Pfeiffer, Modou Cheyassin Phall, Son Thai Pham, Rafael N. Pichardo, Daniela Pierannunzio, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Francesco Pistelli, Freda Pitakaka, Aleksandra Piwonska, Andreia N. Pizarro, Pedro Plans-Rubió, Alina G. Platonova, Bee Koon Poh, Hermann Pohlabeln, Nadija S. Polka, Raluca M. Pop, Stevo R. Popovic, Miquel Porta, Georg Posch, Anil Poudyal, Dimitrios Poulimeneas, Hamed Pouraram, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J. Price, Jacqueline F. Price, Antonio Prista, Rui Providencia, Jardena J. Puder, Iveta Pudule, Maria Puiu, Margus Punab, Muhammed S. Qadir, Radwan F. Qasrawi, Mostafa Qorbani, Hedley K. Quintana, Pedro J. Quiroga-Padilla, Tran Quoc Bao, Stefan Rach, Ivana Radic, Ricardas Radisauskas, Salar Rahimikazerooni, Mahfuzar Rahman, Mahmudur Rahman, Olli Raitakari, Manu Raj, Tamerlan Rajabov, Sherali Rakhmatulloev, Ivo Rakovac, Sudha Ramachandra Rao, Ambady Ramachandran, Otim P. C. Ramadan, Virgílio V. Ramires, Jacqueline Ramke, Elisabete Ramos, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Lalka S. Rangelova, Vayia Rarra, Ramon A. Rascon-Pacheco, Cassiano Ricardo Rech, Josep Redon, Paul Ferdinand M. Reganit, Valéria Regecová, Jane D. P. Renner, Judit A. Repasy, Cézane P. Reuter, Luis Revilla, Abbas Rezaianzadeh, Yeunsook Rho, Lourdes Ribas-Barba, Robespierre Ribeiro, Elio Riboli, Adrian Richter, Fernando Rigo, Attilio Rigotti, Natascia Rinaldo, Tobias F. Rinke de Wit, Ana I. Rito, Raphael M. Ritti-Dias, Juan A. Rivera, Reina G. Roa, Louise Robinson, Cynthia Robitaille, Romana Roccaldo, Daniela Rodrigues, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A. Rodríguez-Villamizar, Andrea Y. Rodríguez, Ulla Roggenbuck, Peter Rohloff, Fabian Rohner, Rosalba Rojas-Martinez, Nipa Rojroongwasinkul, Dora Romaguera, Elisabetta L. Romeo, Rafaela V. Rosario, Annika Rosengren, Ian Rouse, Vanessa Rouzier, Joel G. R. Roy, Maira H. Ruano, Adolfo Rubinstein, Frank J. Rühli, Jean-Bernard Ruidavets, Blanca Sandra Ruiz-Betancourt, Maria Ruiz-Castell, Emma Ruiz Moreno, Iuliia A. Rusakova, Kenisha Russell Jonsson, Paola Russo, Petra Rust, Marcin Rutkowski, Marge Saamel, Charumathi Sabanayagam, Hamideh Sabbaghi, Elena Sacchini, Harshpal S. Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Sare Safi, Saeid Safiri, Mohammad Hossien Saghi, Olfa Saidi, Nader Saki, Sanja Šalaj, Benoit Salanave, Eduardo Salazar Martinez, Calogero Saleva, Diego Salmerón, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Margarita Samoutian, Jose Sánchez-Abanto, Inés Sánchez Rodríguez, Sandjaja, Susana Sans, Loreto Santa Marina, Ethel Santacruz, Diana A. Santos, Ina S. Santos, Lèlita C. Santos, Maria Paula Santos, Osvaldo Santos, Rute Santos, Tamara R. Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Thirunavukkarasu Sathish, Kai-Uwe Saum, Savvas Savva, Mathilde Savy, Norie Sawada, Mariana Sbaraini, Marcia Scazufca, Beatriz D. Schaan, Angelika Schaffrath Rosario, Herman Schargrodsky, Anja Schienkiewitz, Karin Schindler, Sabine Schipf, Carsten O. Schmidt, Ida Maria Schmidt, Andrea Schneider, Peter Schnohr, Ben Schöttker, Sara Schramm, Stine Schramm, Helmut Schröder, Constance Schultsz, Matthias B. Schulze, Aletta E. Schutte, Sylvain Sebert, Moslem Sedaghattalab, Rusidah Selamat, Vedrana Sember, Abhijit Sen, Idowu O. Senbanjo, Sadaf G. Sepanlou, Guillermo Sequera, Luis Serra-Majem, Jennifer Servais, Ľudmila Ševčíková, Svetlana Shalnova, Teresa Shamah-Levy, Seyed Morteza Shamshirgaran, Coimbatore Subramaniam Shanthirani, Maryam Sharafkhah, Sanjib K. Sharma, Jonathan E. Shaw, Amaneh Shayanrad, Ali Akbar Shayesteh, Lela Shengelia, Zumin Shi, Kenji Shibuya, Hana Shimizu-Furusawa, Tal Shimony, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Alfonso Siani, Rosalynn Siantar, Abla M. Sibai, Labros S. Sidossis, Natalia Silitrari, Antonio M. Silva, Caroline Ramos de Moura Silva, Diego Augusto Santos Silva, Kelly S. Silva, Xueling Sim, Mary Simon, Judith Simons, Leon A. Simons, Agneta Sjöberg, Michael Sjöström, Natalia A. Skoblina, Gry Skodje, Tatyana Slazhnyova, Jolanta Slowikowska-Hilczer, Przemysław Slusarczyk, Liam Smeeth, Hung-Kwan So, Fernanda Cunha Soares, Grzegorz Sobek, Eugène Sobngwi, Morten Sodemann, Stefan Söderberg, Moesijanti Y. E. Soekatri, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Emily Sonestedt, Yi Song, Sajid Soofi, Thorkild I. A. Sørensen, Elin P. Sørgjerd, Charles Sossa Jérome, Victoria E. Soto-Rojas, Aïcha Soumaré, Alfonso Sousa-Poza, Slavica Sovic, Bente Sparboe-Nilsen, Karen Sparrenberger, Phoebe R. Spencer, Angela Spinelli, Igor Spiroski, Jan A. Staessen, Hanspeter Stamm, Kaspar Staub, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, George S. Stergiou, Jochanan Stessman, Ranko Stevanović, Jutta Stieber, Doris Stöckl, Jakub Stokwiszewski, Ekaterina Stoyanova, Gareth Stratton, Karien Stronks, Maria Wany Strufaldi, Lela Sturua, Ramón Suárez-Medina, Machi Suka, Chien-An Sun, Liang Sun, Johan Sundström, Yn-Tz Sung, Jordi Sunyer, Paibul Suriyawongpaisal, Nabil William G. Sweis, Boyd A. Swinburn, Rody G. Sy, René Charles Sylva, Moyses Szklo, Lucjan Szponar, Lorraine Tabone, E. Shyong Tai, Konstantinos D. Tambalis, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Maya Tanrygulyyeva, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Jakob Tarp, Carolina B. Tarqui-Mamani, Radka Taxová Braunerová, Anne Taylor, Julie Taylor, Félicité Tchibindat, Saskia Te Velde, William R. Tebar, Grethe S. Tell, Tania Tello, Yih Chung Tham, K. R. Thankappan, Holger Theobald, Xenophon Theodoridis, Nihal Thomas, Barbara Thorand, Betina H. Thuesen, Ľubica Tichá, Erik J. Timmermans, Dwi H. Tjandrarini, Anne Tjonneland, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Roman Topór-Mądry, Liv Elin Torheim, María José Tormo, Michael J. Tornaritis, Maties Torrent, Laura Torres-Collado, Stefania Toselli, Giota Touloumi, Pierre Traissac, Thi Tuyet-Hanh Tran, Mark S. Tremblay, Areti Triantafyllou, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh T. H. Trinh, Atul Trivedi, Yu-Hsiang Tsao, Lechaba Tshepo, Maria Tsigga, Panagiotis Tsintavis, Shoichiro Tsugane, John Tuitele, Azaliia M. Tuliakova, Marshall K. Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L. Turley, Gilad Twig, Per Tynelius, Evangelia Tzala, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Eunice Ugel, Flora A. M. Ukoli, Hanno Ulmer, Belgin Unal, Zhamyila Usupova, Hannu M. T. Uusitalo, Nalan Uysal, Justina Vaitkeviciute, Gonzalo Valdivia, Susana Vale, Damaskini Valvi, Rob M. van Dam, Bert-Jan van den Born, Johan Van der Heyden, Yvonne T. van der Schouw, Koen Van Herck, Wendy Van Lippevelde, Hoang Van Minh, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Anette Varbo, Gregorio Varela-Moreiras, Luz Nayibe Vargas, Patricia Varona-Pérez, Senthil K. Vasan, Daniel G. Vasques, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Biruta Velika, Maïté Verloigne, Giovanni Veronesi, W. M. Monique Verschuren, Cesar G. Victora, Giovanni Viegi, Lucie Viet, Frøydis N. Vik, Monica Vilar, Salvador Villalpando, Jesus Vioque, Jyrki K. Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Mihaela Vladulescu, Tiina Vlasoff, Dorja Vocanec, Peter Vollenweider, Henry Völzke, Ari Voutilainen, Martine Vrijheid, Tanja G. M. Vrijkotte, Alisha N. Wade, Thomas Waldhör, Janette Walton, Elvis O. A. Wambiya, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo de Souza Wanderley Júnior, Ming-Dong Wang, Ningli Wang, Qian Wang, Xiangjun Wang, Ya Xing Wang, Ying-Wei Wang, S. Goya Wannamethee, Nicholas Wareham, Adelheid Weber, Karen Webster-Kerr, Niels Wedderkopp, Daniel Weghuber, Wenbin Wei, Aneta Weres, Bo Werner, Leo D. Westbury, Peter H. Whincup, Kremlin Wickramasinghe, Kurt Widhalm, Indah S. Widyahening, Andrzej Więcek, Philipp S. Wild, Rainford J. Wilks, Johann Willeit, Peter Willeit, Julianne Williams, Tom Wilsgaard, Rusek Wojciech, Bogdan Wojtyniak, Kathrin Wolf, Roy A. Wong-McClure, Andrew Wong, Emily B. Wong, Jyh Eiin Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C. Wu, Hon-Yen Wu, Jianfeng Wu, Li Juan Wu, Shouling Wu, Justyna Wyszyńska, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Uruwan Yamborisut, Weili Yan, Ling Yang, Xiaoguang Yang, Yang Yang, Nazan Yardim, Tabara Yasuharu, Martha Yépez García, Panayiotis K. Yiallouros, Agneta Yngve, Moein Yoosefi, Akihiro Yoshihara, Qi Sheng You, San-Lin You, Novie O. Younger-Coleman, Yu-Ling Yu, Yunjiang Yu, Safiah Md Yusof, Ahmad Faudzi Yusoff, Luciana Zaccagni, Vassilis Zafiropulos, Ahmad A. Zainuddin, Seyed Rasoul Zakavi, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Hana Zamrazilová, Maria Elisa Zapata, Abdul Hamid Zargar, Ko Ko Zaw, Ayman A. Zayed, Tomasz Zdrojewski, Magdalena Żegleń, Kristyna Zejglicova, Tajana Zeljkovic Vrkic, Yi Zeng, Luxia Zhang, Zhen-Yu Zhang, Dong Zhao, Ming-Hui Zhao, Wenhua Zhao, Yanitsa V. Zhecheva, Shiqi Zhen, Wei Zheng, Yingfeng Zheng, Bekbolat Zholdin, Maigeng Zhou, Dan Zhu, Marie Zins, Emanuel Zitt, Yanina Zocalo, Nada Zoghlami, Julio Zuñiga Cisneros, Monika Zuziak, Zulfiqar A. Bhutta, Robert E. Black, Majid Ezzati

Nature 615 ( 7954 ) 874 - 883 2023.3

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Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.

DOI： 10.1038/s41586-023-05772-8

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A cross-sectional study of the association between periodontitis and physical activity in the Japanese population. Reviewed International journal

Masanori Iwasaki, Akihiro Yoshihara, Kana Suwama, Takashi Zaitsu, Seitaro Suzuki, Hikaru Ihira, Norie Sawada, Jun Aida

Journal of periodontal research 58 ( 2 ) 350 - 359 2023.1

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OBJECTIVE: The aim of this study was to determine whether physical activity (PA) is associated with periodontitis in the Japanese population. BACKGROUND: The potential association between PA and periodontitis has not been thoroughly investigated in the Japanese population. METHODS: We used cross-sectional data from the Japan Public Health Center-based Prospective Study for the Next-Generation Oral Health Study. Periodontitis was determined by a full-mouth periodontal examination. PA was assessed using a validated questionnaire. We performed multivariable ordinal logistic regression analyses to assess the association of total PA (the first quintile was set as the reference category) with periodontitis (three categories: no/mild, moderate, and severe), stratified by sex. The associations of periodontitis with domain- and intensity-specific PA were also studied in separate logistic regression models. RESULTS: This study included 2160 Japanese adults [1414 women and 746 men; mean (standard deviation) age 58.1 (9.6) years]. After adjusting for potential confounders, total PA was inversely associated with the presence and severity of periodontitis in women. The multivariable-adjusted odds ratios (95% confidence intervals) for periodontitis in the second to fifth quintiles (compared with the first quintile) of total PA were 0.81 (0.59-1.12), 0.74 (0.53-1.02), 0.77 (0.55-1.06), and 0.64 (0.46-0.89), respectively (p for trend = .01). We did not find different results when we further investigated the associations of periodontitis with domain- and intensity-specific PA. By contrast, PA was not associated with periodontitis in men. CONCLUSION: Total PA had an inverse, linear association with the presence and severity of periodontitis in Japanese women but not in Japanese men. Further prospective studies are required to determine the association between PA and periodontitis.

DOI： 10.1111/jre.13095

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Prevalence and Cause of Enamel Hypoplasia in Primary Teeth among 1-year-old Japanese Children Reviewed

Akane Miyamoto, Kumiko Minagawa, Kaname Nohno, Noboru Kaneko, Yu Ichikawa, Takashi Hoshino, Harue Ito, Akihiro Yoshihara

Open Dentistry Journal 17 ( 1 ) 2023

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DOI： 10.2174/18742106-v17-230303-2022-93

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Career outcomes and satisfaction among graduates of a four-year oral health and welfare baccalaureate program at Niigata University, Japan: a cross-sectional study. Reviewed International journal

Asuka Ishiguro-Matsumoto, Roxana Stegaroiu, Kana Suwama, Satoko Shibata, Akihiro Yoshihara, Akitsugu Ohuchi

International journal of dental hygiene 2022.12

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Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Globally, baccalaureate programs in dental hygiene are increasingly established. In addition, in Japan, many dental hygienists (DHs) and social workers (SWs) are prematurely leaving workforce. This study aimed to investigate, at the most recent employment, career outcomes, reasons for job change, and satisfaction with the job and undergraduate curriculum among graduates of the baccalaureate program at the Department of Oral Health and Welfare (DOHW), Faculty of Dentistry, Niigata University. METHODS: All 262 graduates (graduating classes 1-10) of the DOHW were invited to participate in this survey; an original self-administered questionnaire was distributed to those who consented. Responses were received from 114 (43.5%) graduates. RESULTS: Almost all respondents (89.5%) had dual licensure as both DH and certified SW. They were employed immediately after graduation (99.1%) and at the time of the survey (96.5%). Over 60% of them worked as DHs, mainly in hospitals. SWs mainly worked in administration. Among the 113 respondents who were employed, 39.8% changed jobs at least once. The main reasons for job selection were 'interest in job content' and 'flexible working hours'. Nearly 90% of the respondents felt satisfied or fairly satisfied with their job and the undergraduate education. CONCLUSIONS: A quality four-year baccalaureate degree program in dental hygiene and social welfare positively influenced graduates' work continuity. Most graduates felt satisfied or fairly satisfied with their job and the undergraduate curriculum. Employment rates within each profession and prevalence of hospital and administrative roles were higher than national averages. Long-term studies of graduates' career outcomes are warranted.

DOI： 10.1111/idh.12655

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Effects of Interval Walking Training on Oral Health Status in Middle-Aged and Older Adults: A Case-Control Study. Reviewed International journal

Tasuku Yoshimoto, Yoko Hasegawa, Mayuka Furihata, Akihiro Yoshihara, Masako Shiramizu, Ma Therese Sta Maria, Shoko Hori, Mayuko Morikawa, Pinta Marito, Noboru Kaneko, Kaname Nohno, Hiroshi Nose, Shizue Masuki, Takahiro Ono

International journal of environmental research and public health 19 ( 21 ) 2022.11

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The purpose of this study was to determine the effect of walking training "Interval Walking Training (IWT)" on oral health status. Participants were divided into two groups: an exercise intervention group and a non-intervention group (control). The intervention group consisted of 59 subjects (20 males, 39 females) aged 50 years or older who participated in the IWT program in Matsumoto from 2019 to April 2022. The control group consisted of 33 subjects (14 males and 19 females) aged 50 years or older who have visited Niigata University Medical and Dental Hospital and agreed to participate in the study. The intervention group underwent walking training (interval walking training) for at least 5-6 months. The walking training consisted of five sets of fast walking above 70% peak aerobic capacity for walking (VO2peak) for 3 min, followed by 3 min of slow walking at ~40% VO2 peak per day for more than four days/week. The oral health status was evaluated for the number of teeth, occlusal force, salivary occult blood, masticatory performance, and tongue pressure. A total of 57 participants were analyzed in the intervention group (18 males and 39 females, age: 66.7 ± 0.8 (mean ± S.E.) years) and 33 participants in the control group (14 males and 19 females, age: 74.5 ± 1.1 (mean ± S.E.) years). There were no significant differences in gender, salivary occult blood, tongue pressure, masticatory performance, or occlusal force between the two groups at the start of the intervention (p = 0.36, p = 0.48, p = 0.42, p = 0.58, and p = 0.08, respectively by unpaired t-test or χ2 test). On the other hand, there were significant differences in age and BMI, with a trend toward lower age and higher BMI in the intervention group (p < 0.001 and p < 0.001, respectively, by unpaired t-test). In terms of rate of change, the intervention group showed a significant increase in occlusal force (F = 4.5, p = 0.04, ANCOVA) and a significant decrease in BMI (F = 7.3, p = 0.009, ANCOVA). No significant differences were observed in the other measured items. It was found that walking training in both middle-aged and older people does not only affect the physical aspect of weight loss but may help maintain and improve the occlusal force.

DOI： 10.3390/ijerph192114465

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Association of Hyper-Low-Density Lipoprotein and Hypo-High-Density Lipoprotein Cholesterolemia with Low Saliva Flow Rates in Japanese Community-Dwelling Elders Reviewed

Nana Mizoguchi, Kaname Nohno, Akihiro Yoshihara, Kayoko Ito, Saori Funayama, Hiroshi Ogawa

International Archives of Otorhinolaryngology 2022.7

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Publishing type：Research paper (scientific journal) Publisher：Georg Thieme Verlag KG

Abstract

Introduction The associations of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein (HDL-C) with reduced saliva flow rates have not been previously reported.

Objective The present study aimed to assess the association of cholesterolemia with reduced saliva flow rates in community-dwelling elderly subjects.

Methods The present study analyzed 342 participants (170 males and 172 females aged between 78 and 79 years old). Unstimulated salivary flow rate (USFR) was assessed using a cotton roll method. Low-USFR was defined as 0.10 g/30 seconds. Stimulated salivary flow rate (SSFR) was assessed by having the participants chew tasteless gum for 3 minutes. Low-SSFR was defined as 1.0 mL/minute. Blood samples were collected for the measurement of LDL-C, HDL-C, rheumatoid factor, hemoglobin A1c, and creatinine. To assess depression, the General Health Questionnaire 30 was used. A standardized questionnaire was completed, covering the current and previous medications of the participants and smoking status. We stratified the serum LDL-C levels of the participants as normal, moderate or severe hyper-LDL cholesterolemia and serum HDL-C levels as normal or hypo-HDL cholesterolemia. Multivariate logistic regression models were established and low-USFR or low-SSFR were set as dependent variables in the aforementioned models.

Results After controlling for the effects of the other variables, the odds ratios (ORs) (95% confidence intervals [CIs]) for low-USFR were 2.25 (1.10–4.61) for moderate and 5.69 (1.55–20.8) for severe hyper-LDL cholesterolemia, while that of hypo-HDL cholesterolemia was 3.40 (1.33–8.69). Severe hyper-LDL cholesterolemia was also associated with low-SSFR with an OR of 3.89 (1.39–10.88).

Conclusion Elderly patients with cholesterolemia have a risk of reduced salivary flow rate.

DOI： 10.1055/s-0042-1744167

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根面う蝕管理のためのフッ化物応用についてフッ化ジアンミン銀、フッ化物バニッシュを中心に

宮本茜, 葭原明弘

口腔衛生学会雑誌 72 ( 3 ) 152 - 157 2022.7

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Language：Japanese Publisher：(一社)日本口腔衛生学会

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00440&link_issn=&doc_id=20220815170001&doc_link_id=%2Fdk1dehea%2F2022%2F007203%2F001%2F0152-0157%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2022%2F007203%2F001%2F0152-0157%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Interaction between serum vitamin C levels and smoking on the periodontal condition in older adults. Reviewed International journal

Akihiro Yoshihara, Keisuke Nakashima, Kana Suwama, Ayuko Odajima, Takayuki Yamaga, Hiroshi Ogawa

Journal of periodontal research 2022.4

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Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND OBJECTIVES: Several epidemiological studies have reported that smokers have a higher prevalence and severity of periodontal disease than do nonsmokers, and that smoking negatively affects nutritional status and is associated with a reduced intake of antioxidants, particularly vitamin C. The present investigation aimed to examine the relationship between serum vitamin C levels and smoking and its influence on the periodontal condition in older adults. MATERIALS AND METHODS: A total of 353 respondents met the inclusion criteria and were enrolled in the present study. The periodontal status of the study participants was determined through examinations of one or more residual teeth, which included a measurement of the probing pocket depth (PPD) and clinical attachment level (CAL) at six regions of each tooth. Blood samples were collected during the dental examinations and then sent to a laboratory to evaluate serum vitamin C and cotinine levels. A serum cotinine concentration of 100 ng/ml was considered a relevant threshold for active smoking. After dividing the participants into two groups according to serum cotinine levels, Poisson regression analysis was carried out to compare vitamin C levels with the prevalence rate ratio (PRR) for periodontal condition markers for each group based on serum cotinine levels. RESULTS: We evaluated differences in the PRR of serum vitamin C tertiles between participants with high (≥100 ng/ml) or low (<100 ng/ml) serum cotinine levels after adjusting for sex, the use of interdental brushes or dental floss, and the number of teeth. A negative tendency between the PRR of vitamin C tertiles for the PPD or CAL was seen for both groups. Especially, a bigger difference was observed in the group with high serum cotinine levels. The PRR of the first tertiles in the high serum cotinine group was 5.03, compared with 2.69 in the low serum cotinine group (relative risk: 1.9). CONCLUSION: The results of this study suggest a potential association between vitamin C levels and the periodontal condition, which may be influenced by smoking status.

DOI： 10.1111/jre.12988

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小学生における口唇閉鎖力の年齢による変化と関連要因についての研究 Reviewed

諏訪間加奈, 野上有紀子, 葭原明弘

口腔衛生学会雑誌 72 ( 2 ) 92 - 99 2022.4

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Language：Japanese Publisher：(一社)日本口腔衛生学会

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地域在住高齢者を対象とした口腔機能訓練が与える頸部可動域の改善効果 Reviewed

小田島あゆ子, 葭原明弘, 石上和男

口腔衛生学会雑誌 72 ( 1 ) 11 - 17 2022.1

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Effects of Oral Function Training and Oral Health Status on Physical Performance in Potentially Dependent Older Adults Reviewed

Masataka Sasajima, Akihiro Yoshihara, Ayuko Odajima

International Journal of Environmental Research and Public Health 18 ( 21 ) 11348 - 11348 2021.10

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Publishing type：Research paper (scientific journal) Publisher：MDPI AG

This study aimed to evaluate the effects of an oral function training program and indicators of oral health status on improvements in physical performance induced by physical function training in dependent older adults. The participants were 131 potentially dependent older adults (age: ≥65 years) who were randomly divided into two groups: an oral intervention and a control group. All participants underwent physical function training, but only the intervention group took part in the oral function training program. In total, 106 participants completed all of the survey components (60 and 46 participants from the intervention and control groups, respectively). The measures of physical fitness examined included the one-leg standing time with eyes open (OLST) and the timed up and go test (TUG). Logistic regression analyses were carried out to determine the effects of the oral function intervention and health status on physical fitness. The results revealed that the oral function intervention significantly improved OLST and TUG times. These findings suggest that evaluations of oral health status and interventions aimed at activating oral functions are associated with improvements in physical fitness among potentially dependent older adults.

DOI： 10.3390/ijerph182111348

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Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants Reviewed

Bin Zhou, Rodrigo M Carrillo-Larco, Goodarz Danaei, Leanne M Riley, Christopher J Paciorek, Gretchen A Stevens, Edward W Gregg, James E Bennett, Bethlehem Solomon, Rosie K Singleton, Marisa K Sophiea, Maria LC Iurilli, Victor PF Lhoste, Melanie J Cowan, Stefan Savin, Mark Woodward, Yulia Balanova, Renata Cifkova, Albertino Damasceno, Paul Elliott, Farshad Farzadfar, Jiang He, Nayu Ikeda, Andre P Kengne, Young-Ho Khang, Hyeon Chang Kim, Avula Laxmaiah, Hsien-Ho Lin, Paula Margozzini Maira, J Jaime Miranda, Hannelore Neuhauser, Johan Sundström, Cherian Varghese, Indah S Widyahening, Tomasz Zdrojewski, Leandra Abarca-Gómez, Ziad A Abdeen, Hanan F Abdul Rahim, Niveen M Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Shoaib Afzal, Imelda A Agdeppa, Javad Aghazadeh-Attari, Carlos A Aguilar-Salinas, Charles Agyemang, Noor Ani Ahmad, Ali Ahmadi, Naser Ahmadi, Nastaran Ahmadi, Fariba Ahmadizar, Soheir H Ahmed, Wolfgang Ahrens, Kamel Ajlouni, Rajaa Al-Raddadi, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Mohamed M Ali, Abdullah Alkandari, Ala'a Alkerwi, Kristine Allin, Eman Aly, Deepak N Amarapurkar, Norbert Amougou, Philippe Amouyel, Lars Bo Andersen, Sigmund A Anderssen, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Daniel Ansong, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E Arku, Nimmathota Arlappa, Krishna K Aryal, Thor Aspelund, Felix K Assah, Maria Cecília F Assunção, Juha Auvinen, Mária Avdićová, Ana Azevedo, Mohsen Azimi-Nezhad, Fereidoun Azizi, Mehrdad Azmin, Bontha V Babu, Suhad Bahijri, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Maja Banadinović, Piotr Bandosz, José R Banegas, Joanna Baran, Carlo M Barbagallo, Alberto Barceló, Amina Barkat, Marta Barreto, Aluisio JD Barros, Mauro Virgílio Gomes Barros, Anna Bartosiewicz, Abdul Basit, Joao Luiz D Bastos, Iqbal Bata, Anwar M Batieha, Assembekov Batyrbek, Louise A Baur, Robert Beaglehole, Antonisamy Belavendra, Habiba Ben Romdhane, Mikhail Benet, Lowell S Benson, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloísa Bettiol, Jorge Bezerra, Aroor Bhagyalaxmi, Santosh K Bhargava, Daniel Bia, Katia Biasch, Elysée Claude Bika Lele, Mukharram M Bikbov, Bihungum Bista, Peter Bjerregaard, Espen Bjertness, Marius B Bjertness, Cecilia Björkelund, Katia V Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Heiner Boeing, Jose G Boggia, Carlos P Boissonnet, Stig E Bojesen, Vanina Bongard, Alice Bonilla-Vargas, Matthias Bopp, Herman Borghs, Pascal Bovet, Christopher B Boyer, Lutgart Braeckman, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, Hermann Brenner, Lizzy M Brewster, Yajaira Briceño, Miguel Brito, Graziella Bruno, H Bas Bueno-de-Mesquita, Gloria Bueno, Anna Bugge, Con Burns, Michael Bursztyn, Antonio Cabrera de León, Joseph Cacciottolo, Christine Cameron, Günay Can, Ana Paula C Cândido, Mario V Capanzana, Naděžda Čapková, Eduardo Capuano, Vincenzo Capuano, Viviane C Cardoso, Axel 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The Lancet 398 ( 10304 ) 957 - 980 2021.9

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Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/s0140-6736(21)01330-1

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Language：Japanese Publisher：新潟歯学会

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J00440&link_issn=&doc_id=20210813270001&doc_link_id=%2Fdk1dehea%2F2021%2F007103%2F001%2F0126-0135%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2021%2F007103%2F001%2F0126-0135%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
地域在宅超高齢者の食事パターンと栄養素摂取量、栄養状態および嚥下状態との関連

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口腔衛生学会雑誌 71 ( 3 ) 136 - 146 2021.7

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65歳以上のメタボリックシンドローム有病者における現在歯数と心の健康状態の関連魚沼コホート調査より

皆川久美子, 葭原明弘, 諏訪間加奈, 小川祐司

口腔衛生学会雑誌 71 ( 増刊 ) 111 - 111 2021.4

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Language：Japanese Publisher：(一社)日本口腔衛生学会

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65歳以上のメタボリックシンドローム有病者における現在歯数と心の健康状態の関連魚沼コホート調査より

皆川久美子, 葭原明弘, 諏訪間加奈, 小川祐司

口腔衛生学会雑誌 71 ( 増刊 ) 111 - 111 2021.4

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Language：Japanese Publisher：(一社)日本口腔衛生学会

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地域在住高齢者における刺激唾液量の減少に関連する因子の探索 1年縦断調査

濃野要, 金子昇, 伊藤加代子, 船山さおり, 葭原明弘, 小川祐司

口腔衛生学会雑誌 71 ( 増刊 ) 114 - 114 2021.4

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Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight Reviewed

Maria LC Iurilli, Bin Zhou, James E Bennett, Rodrigo M Carrillo-Larco, Marisa K Sophiea, Andrea Rodriguez-Martinez, Honor Bixby, Bethlehem D Solomon, Cristina Taddei, Goodarz Danaei, Mariachiara Di Cesare, Gretchen A Stevens, Leanne M Riley, Stefan Savin, Melanie J Cowan, Pascal Bovet, Albertino Damasceno, Adela Chirita-Emandi, Alison J Hayes, Nayu Ikeda, Rod T Jackson, Young-Ho Khang, Avula Laxmaiah, Jing Liu, J Jaime Miranda, Olfa Saidi, Sylvain Sebert, Maroje Sorić, Gregor Starc, Edward W Gregg, Leandra Abarca-Gómez, Ziad A Abdeen, Shynar Abdrakhmanova, Suhaila Abdul Ghaffar, Hanan F Abdul Rahim, Niveen M Abu-Rmeileh, Jamila Abubakar Garba, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Shoaib Afzal, Imelda A Agdeppa, Javad Aghazadeh-Attari, Carlos A Aguilar-Salinas, Charles Agyemang, Mohamad Hasnan Ahmad, Noor Ani Ahmad, Ali Ahmadi, Naser Ahmadi, Soheir H Ahmed, Wolfgang Ahrens, Gulmira Aitmurzaeva, Kamel Ajlouni, Hazzaa M Al-Hazzaa, Badreya Al-Lahou, Rajaa Al-Raddadi, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Mohamed M Ali, Abdullah Alkandari, Ala'a Alkerwi, Kristine Allin, Mar Alvarez-Pedrerol, Eman Aly, Deepak N Amarapurkar, Parisa Amiri, Norbert Amougou, Philippe Amouyel, Lars Bo Andersen, Sigmund A Anderssen, Lars Ängquist, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E Arku, Nimmathota Arlappa, Krishna K Aryal, Thor Aspelund, Felix K Assah, Maria Cecília F Assunção, May Soe Aung, Juha Auvinen, Mária Avdicová, Shina Avi, Ana Azevedo, Mohsen Azimi-Nezhad, Fereidoun Azizi, Mehrdad Azmin, Bontha V Babu, Maja Bæksgaard Jørgensen, Azli Baharudin, Suhad Bahijri, Jennifer L Baker, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R Banegas, Joanna Baran, Carlo M Barbagallo, Alberto Barceló, Amina Barkat, Aluisio JD Barros, Mauro Virgílio Gomes Barros, Abdul Basit, Joao Luiz D Bastos, Iqbal Bata, Anwar M Batieha, Rosangela L Batista, Zhamilya Battakova, Assembekov Batyrbek, Louise A Baur, Robert Beaglehole, Silvia Bel-Serrat, Antonisamy Belavendra, Habiba Ben Romdhane, Judith Benedics, Mikhail Benet, Ingunn Holden Bergh, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloísa Bettiol, Jorge Bezerra, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K Bhargava, Zulfiqar A Bhutta, Hongsheng Bi, Yufang Bi, Daniel Bia, Elysée Claude Bika Lele, Mukharram M Bikbov, Bihungum Bista, Dusko J Bjelica, Peter Bjerregaard, Espen Bjertness, Marius B Bjertness, Cecilia Björkelund, Katia V Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Lynne M Boddy, Bernhard O Boehm, Heiner Boeing, Jose G Boggia, Elena Bogova, Carlos P Boissonnet, Stig E Bojesen, Marialaura Bonaccio, Vanina Bongard, Alice Bonilla-Vargas, Matthias Bopp, Herman Borghs, Lien Braeckevelt, Lutgart Braeckman, Marjolijn CE Bragt, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, João Breda, Hermann Brenner, Lizzy M Brewster, Garry R Brian, Lacramioara Brinduse, Sinead Brophy, Graziella Bruno, H Bas Bueno-de-Mesquita, Anna Bugge, Marta Buoncristiano, Genc Burazeri, Con Burns, Antonio Cabrera de León, Joseph Cacciottolo, Hui Cai, Tilema Cama, Christine Cameron, José Camolas, Günay Can, Ana Paula C Cândido, Felicia Cañete, Mario V Capanzana, Nadežda Capková, Eduardo Capuano, Vincenzo Capuano, Marloes Cardol, Viviane C Cardoso, Axel C Carlsson, Esteban Carmuega, Joana Carvalho, José A Casajús, Felipe F Casanueva, Ertugrul Celikcan, Laura Censi, Marvin Cervantes-Loaiza, Juraci A Cesar, Snehalatha Chamukuttan, Angelique W Chan, Queenie Chan, Himanshu K Chaturvedi, Nish Chaturvedi, Norsyamlina Che Abdul Rahim, Miao Li Chee, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Bahman Cheraghian, Angela Chetrit, Ekaterina Chikova-Iscener, Arnaud Chiolero, Shu-Ti Chiou, María-Dolores Chirlaque, Belong Cho, Kaare Christensen, Diego G Christofaro, Jerzy Chudek, Renata Cifkova, Michelle Cilia, Eliza Cinteza, Frank Claessens, Janine Clarke, Els Clays, Emmanuel Cohen, Hans Concin, Susana C Confortin, Cyrus Cooper, Tara C Coppinger, Eva Corpeleijn, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L Craig, Amelia C Crampin, Ana B Crujeiras, Semánová Csilla, Alexandra M Cucu, Liufu Cui, Felipe V Cureau, Ewelina Czenczek-Lewandowska, Graziella D'Arrigo, Eleonora d'Orsi, Liliana Dacica, María Ángeles Dal Re Saavedra, Jean Dallongeville, Camilla T Damsgaard, Rachel Dankner, Thomas M Dantoft, Parasmani Dasgupta, Saeed Dastgiri, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, David De Ridder, Karin De Ridder, Susanne R de Rooij, Delphine De Smedt, Mohan Deepa, Alexander D Deev, Vincent Jr DeGennaro, Abbas Dehghan, Hélène Delisle, Francis Delpeuch, Stefaan Demarest, Elaine Dennison, Katarzyna Dereń, Valérie Deschamps, Meghnath Dhimal, Augusto F Di Castelnuovo, Juvenal Soares Dias-da-Costa, María Elena Díaz-Sánchez, Alejandro Diaz, Zivka Dika, Shirin Djalalinia, Visnja Djordjic, Ha TP Do, Annette J Dobson, Maria Benedetta Donati, Chiara Donfrancesco, Silvana P Donoso, Angela Döring, Maria Dorobantu, Ahmad Reza Dorosty, Kouamelan Doua, Nico Dragano, Wojciech Drygas, Jia Li Duan, Charmaine A Duante, Priscilla Duboz, Rosemary B Duda, Vesselka Duleva, Virginija Dulskiene, Samuel C Dumith, Anar Dushpanova, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Ricky Eddie, Ebrahim Eftekhar, Eruke E Egbagbe, Robert Eggertsen, Sareh Eghtesad, Gabriele Eiben, Ulf Ekelund, Mohammad El-Khateeb, Jalila El Ati, Denise Eldemire-Shearer, Marie Eliasen, Paul Elliott, Reina Engle-Stone, Macia Enguerran, Rajiv T Erasmus, Raimund Erbel, Cihangir Erem, Louise Eriksen, Johan G Eriksson, Jorge Escobedo-de la Peña, Saeid Eslami, Ali Esmaeili, Alun Evans, David Faeh, Albina A Fakhretdinova, Caroline H Fall, Elnaz Faramarzi, Mojtaba Farjam, Victoria Farrugia Sant'Angelo, Farshad Farzadfar, Mohammad Reza Fattahi, Asher Fawwad, Francisco J Felix-Redondo, Trevor S Ferguson, Romulo A Fernandes, Daniel Fernández-Bergés, Daniel Ferrante, Thomas Ferrao, Marika Ferrari, Marco M Ferrario, Catterina Ferreccio, Eldridge Ferrer, Jean Ferrieres, Thamara Hubler Figueiró, Anna Fijalkowska, Günther Fink, Krista Fischer, Leng Huat Foo, Maria Forsner, Heba M Fouad, Damian K Francis, Maria do Carmo Franco, Ruth Frikke-Schmidt, Guillermo Frontera, Flavio D Fuchs, Sandra C Fuchs, Isti I Fujiati, Yuki Fujita, Matsuda Fumihiko, Takuro Furusawa, Zbigniew Gaciong, Mihai Gafencu, Andrzej Galbarczyk, Henrike Galenkamp, Daniela Galeone, Myriam Galfo, Fabio Galvano, Jingli Gao, Manoli Garcia-de-la-Hera, Marta García-Solano, Dickman Gareta, Sarah P Garnett, Jean-Michel Gaspoz, Magda Gasull, Adroaldo Cesar Araujo Gaya, Anelise Reis Gaya, Andrea Gazzinelli, Ulrike Gehring, Harald Geiger, Johanna M Geleijnse, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Simona Giampaoli, Francesco Gianfagna, Tiffany K Gill, Jonathan Giovannelli, Glen Gironella, Aleksander Giwercman, Konstantinos Gkiouras, Justyna Godos, Sibel Gogen, Marcel Goldberg, Rebecca A Goldsmith, David Goltzman, Santiago F Gómez, Aleksandra Gomula, Bruna Goncalves Cordeiro da Silva, Helen Gonçalves, David A Gonzalez-Chica, Marcela Gonzalez-Gross, Margot González-Leon, Juan P González-Rivas, Clicerio González-Villalpando, María-Elena González-Villalpando, Angel R Gonzalez, Frederic Gottrand, Antonio Pedro Graça, Sidsel Graff-Iversen, Dušan Grafnetter, Aneta Grajda, Maria G Grammatikopoulou, Ronald D Gregor, Tomasz Grodzicki, Else Karin Grøholt, Anders Grøntved, Giuseppe Grosso, Gabriella Gruden, Dongfeng Gu, Emanuela Gualdi-Russo, Pilar Guallar-Castillón, Andrea Gualtieri, Elias F Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L Guimaraes, Martin C Gulliford, Johanna Gunnlaugsdottir, Marc J Gunter, Xiu-Hua Guo, Yin Guo, Prakash C Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Enrique Gutiérrez-González, Laura Gutierrez, Felix Gutzwiller, Seongjun Ha, Farzad Hadaegh, Charalambos A Hadjigeorgiou, Rosa Haghshenas, Hamid Hakimi, Jytte Halkjær, Ian R Hambleton, Behrooz Hamzeh, Dominique Hange, Abu AM Hanif, Sari Hantunen, Jie Hao, Rachakulla Hari Kumar, Seyed Mohammad Hashemi-Shahri, Maria Hassapidou, Jun Hata, Teresa Haugsgjerd, Jiang He, Yuan He, Yuna He, Regina Heidinger-Felso, Mirjam Heinen, Tatjana Hejgaard, Marleen Elisabeth Hendriks, Rafael dos Santos Henrique, Ana Henriques, Leticia Hernandez Cadena, Sauli Herrala, Victor M Herrera, Isabelle Herter-Aeberli, Ramin Heshmat, Allan G Hill, Sai Yin Ho, Suzanne C Ho, Michael Hobbs, Michelle Holdsworth, Reza Homayounfar, Clara Homs, Wilma M Hopman, Andrea RVR Horimoto, Claudia M Hormiga, Bernardo L Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Ilpo Tapani Huhtaniemi, Laetitia Huiart, Constanta Huidumac Petrescu, Martijn Huisman, Abdullatif Husseini, Chinh Nguyen Huu, Inge Huybrechts, Nahla Hwalla, Jolanda Hyska, Licia Iacoviello, Jesús M Ibarluzea, Mohsen M Ibrahim, Norazizah Ibrahim Wong, M Arfan Ikram, Violeta Iotova, Vilma E Irazola, Takafumi Ishida, Muhammad Islam, Sheikh Mohammed Shariful Islam, Masanori Iwasaki, Jeremy M Jacobs, Hashem Y Jaddou, Tazeen Jafar, Kenneth James, Kazi M Jamil, Konrad Jamrozik, Imre Janszky, Edward Janus, Juel Jarani, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelakovic, Bojan Jelakovic, Garry Jennings, Anjani Kumar Jha, Chao Qiang Jiang, Ramon O Jimenez, Karl-Heinz Jöckel, Michel Joffres, Mattias Johansson, Jari J Jokelainen, Jost B Jonas, Jitendra Jonnagaddala, Torben Jørgensen, Pradeep Joshi, Farahnaz Joukar, Dragana P Jovic, Jacek J Jóźwiak, Anne Juolevi, Gregor Jurak, Iulia Jurca Simina, Vesna Juresa, Rudolf Kaaks, Felix O Kaducu, Anthony Kafatos, Eero O Kajantie, Zhanna Kalmatayeva, Ofra Kalter-Leibovici, Yves Kameli, Freja B Kampmann, Kodanda R Kanala, Srinivasan Kannan, Efthymios Kapantais, Argyro Karakosta, Line L Kårhus, Khem B Karki, Marzieh Katibeh, Joanne Katz, Peter T Katzmarzyk, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli M Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Cecily Kelleher, Han CG Kemper, Andre P Kengne, Maryam Keramati, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Kay-Tee Khaw, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ilse MSL Khouw, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Japhet Killewo, Dong Wook Kim, Hyeon Chang Kim, Jeongseon Kim, Jenny M Kindblom, Heidi Klakk, Magdalena Klimek, Jeannette Klimont, Jurate Klumbiene, Michael Knoflach, Bhawesh Koirala, Elin Kolle, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Magdalena Korzycka, Jelena Kos, Seppo Koskinen, Katsuyasu Kouda, Viktoria A Kovacs, Sudhir Kowlessur, Slawomir Koziel, Jana Kratenova, Wolfgang Kratzer, Susi Kriemler, Peter Lund Kristensen, Steiner Krokstad, Daan Kromhout, Herculina S Kruger, Ruzena Kubinova, Renata Kuciene, Urho M Kujala, Enisa Kujundzic, Zbigniew Kulaga, R Krishna Kumar, Marie Kunešová, Pawel Kurjata, Yadlapalli S Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Quang Ngoc La, Fatima Zahra Laamiri, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Christina-Paulina Lambrinou, Edwige Landais, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Laura Lauria, Maria Lazo-Porras, Gwenaëlle Le Coroller, Khanh Le Nguyen Bao, Agnès Le Port, Tuyen D Le, Jeannette Lee, Jeonghee Lee, Paul H Lee, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Naomi S Levitt, Yanping Li, Merike Liivak, Christa L Lilly, Wei-Yen Lim, M Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Yi-Ting Lin, Lars Lind, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Lijuan Liu, Wei-Cheng Lo, Helle-Mai Loit, Khuong Quynh Long, Luis Lopes, Oscar Lopes, Esther Lopez-Garcia, Tania Lopez, Paulo A Lotufo, José Eugenio Lozano, Janice L Lukrafka, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Nuno Lunet, Charles Lunogelo, Michala Lustigová, Edyta Łuszczki, Guansheng Ma, Jun Ma, Xu Ma, George LL Machado-Coelho, Aristides M Machado-Rodrigues, Luisa M Macieira, Ahmed A Madar, Stefania Maggi, Dianna J Magliano, Sara Magnacca, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marjeta Majer, Marcia Makdisse, Päivi Mäki, Fatemeh Malekzadeh, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia K Malyutina, Lynell V Maniego, Yannis Manios, Jim I Mann, Fariborz Mansour-Ghanaei, Enzo Manzato, Paula Margozzini, Anastasia Markaki, Oonagh Markey, Eliza Markidou Ioannidou, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Yves Martin-Prevel, Rosemarie Martin, Reynaldo Martorell, Eva Martos, Katharina Maruszczak, Stefano Marventano, Luis P Mascarenhas, Shariq R Masoodi, Ellisiv B Mathiesen, Prashant Mathur, Alicia Matijasevich, Tandi E Matsha, Christina Mavrogianni, Artur Mazur, Jean Claude N Mbanya, Shelly R McFarlane, Stephen T McGarvey, Martin McKee, Stela McLachlan, Rachael M McLean, Scott B McLean, Breige A McNulty, Sounnia Mediene Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Jørgen Meisfjord, Christa Meisinger, Ana Maria B Menezes, Geetha R Menon, Gert BM Mensink, Maria Teresa Menzano, Alibek Mereke, Indrapal I Meshram, Andres Metspalu, Haakon E Meyer, Jie Mi, Kim F Michaelsen, Nathalie Michels, Kairit Mikkel, Karolina Milkowska, Jody C Miller, Cláudia S Minderico, GK Mini, Juan Francisco Miquel, Mohammad Reza Mirjalili, Daphne Mirkopoulou, Erkin Mirrakhimov, Marjeta Mišigoj-Durakovic, Antonio Mistretta, Veronica Mocanu, Pietro A Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K Mohamed, Shukri F Mohamed, Kazem Mohammad, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Farnam Mohebi, Marie Moitry, Drude Molbo, Line T Møllehave, Niels C Møller, Dénes Molnár, Amirabbas Momenan, Charles K Mondo, Michele Monroy-Valle, Eric Monterrubio-Flores, Kotsedi Daniel K Monyeki, Jin Soo Moon, Mahmood Moosazadeh, Leila B Moreira, Alain Morejon, Luis A Moreno, Karen Morgan, Suzanne N Morin, Erik Lykke Mortensen, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Anabela Mota-Pinto, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Marcos André Moura-dos-Santos, Malay K Mridha, Kelias P Msyamboza, Thet Thet Mu, Magdalena Muc, Boban Mugoša, Maria L Muiesan, Parvina Mukhtorova, Martina Müller-Nurasyid, Neil Murphy, Jaakko Mursu, Elaine M Murtagh, Kamarul Imran Musa, Sanja Music Milanovic, Vera Musil, Norlaila Mustafa, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Balkish M Naidu, Farid Najafi, Harunobu Nakamura, Jana Námešná, Ei Ei K Nang, Vinay B Nangia, Martin Nankap, Sameer Narake, Paola Nardone, Matthias Nauck, William A Neal, Azim Nejatizadeh, Chandini Nekkantti, Keiu Nelis, Liis Nelis, Ilona Nenko, Martin Neovius, Flavio Nervi, Chung T Nguyen, Nguyen D Nguyen, Quang Ngoc Nguyen, Ramfis E Nieto-Martínez, Yury P Nikitin, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Oscar A Noboa, Helena Nogueira, Teresa Norat, Maria Nordendahl, Børge G Nordestgaard, Davide Noto, Natalia Nowak-Szczepanska, Mohannad Al Nsour, Irfan Nuhoglu, Eha Nurk, Terence W O'Neill, Dermot O'Reilly, Galina Obreja, Caleb Ochimana, Angélica M Ochoa-Avilés, Eiji Oda, Kyungwon Oh, Kumiko Ohara, Claes Ohlsson, Ryutaro Ohtsuka, Örn Olafsson, Maria Teresa A Olinto, Isabel O Oliveira, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Lariane M Ono, Pedro Ordunez, Rui Ornelas, Ana P Ortiz, Pedro J Ortiz, Merete Osler, Clive Osmond, Sergej M Ostojic, Afshin Ostovar, Johanna A Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Ioannis Pagkalos, Elena Pahomova, Karina Mary de Paiva, Andrzej Pajak, Domenico Palli, Alberto Palloni, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Arvind Pandey, Francesco Panza, Dimitrios Papandreou, Soon-Woo Park, Suyeon Park, Winsome R Parnell, Mahboubeh Parsaeian, Ionela M Pascanu, Patrick Pasquet, Nikhil D Patel, Ivan Pecin, Mangesh S Pednekar, Nasheeta Peer, Gao Pei, Sergio Viana Peixoto, Markku Peltonen, Alexandre C Pereira, Marco A Peres, Napoleón Pérez-Farinós, Cynthia M Pérez, Valentina Peterkova, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Ausra Petrauskiene, Emanuela Pettenuzzo, Niloofar Peykari, Son Thai Pham, Rafael N Pichardo, Daniela Pierannunzio, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Francesco Pistelli, Freda Pitakaka, Aleksandra Piwonska, Andreia N Pizarro, Pedro Plans-Rubió, Bee Koon Poh, Hermann Pohlabeln, Raluca M Pop, Stevo R Popovic, Miquel Porta, Georg Posch, Anil Poudyal, Dimitrios Poulimeneas, Hamed Pouraram, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J Price, Jacqueline F Price, Rui Providencia, Jardena J Puder, Iveta Pudule, Soile E Puhakka, Maria Puiu, Margus Punab, Radwan F Qasrawi, Mostafa Qorbani, Tran Quoc Bao, Ivana Radic, Ricardas Radisauskas, Salar Rahimikazerooni, Mahfuzar Rahman, Mahmudur Rahman, Olli Raitakari, Manu Raj, Ellina Rakhimova, Sherali Rakhmatulloev, Ivo Rakovac, Sudha Ramachandra Rao, Ambady Ramachandran, Jacqueline Ramke, Elisabete Ramos, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Vayia Rarra, Ramon A Rascon-Pacheco, Mette Rasmussen, Cassiano Ricardo Rech, Josep Redon, Paul Ferdinand M Reganit, Valéria Regecová, Luis Revilla, Abbas Rezaianzadeh, Lourdes Ribas-Barba, Robespierre Ribeiro, Elio Riboli, Adrian Richter, Fernando Rigo, Natascia Rinaldo, Tobias F Rinke de Wit, Ana Rito, Raphael M Ritti-Dias, Juan A Rivera, Cynthia Robitaille, Romana Roccaldo, Daniela Rodrigues, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A Rodríguez-Villamizar, Ulla Roggenbuck, Rosalba Rojas-Martinez, Nipa Rojroongwasinkul, Dora Romaguera, Elisabetta L Romeo, Rafaela V Rosario, Annika Rosengren, Ian Rouse, Joel GR Roy, Adolfo Rubinstein, Frank J Rühli, Jean-Bernard Ruidavets, Blanca Sandra Ruiz-Betancourt, Maria Ruiz-Castell, Emma Ruiz Moreno, Iuliia A Rusakova, Kenisha Russell Jonsson, Paola Russo, Petra Rust, Marcin Rutkowski, Charumathi Sabanayagam, Elena Sacchini, Harshpal S Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Saeid Safiri, Nader Saki, Benoit Salanave, Eduardo Salazar Martinez, Diego Salmerón, Veikko Salomaa, Jukka T Salonen, Massimo Salvetti, Margarita Samoutian, Jose Sánchez-Abanto, Sandjaja, Susana Sans, Loreto Santa Marina, Diana A Santos, Ina S Santos, Lèlita C Santos, Maria Paula Santos, Osvaldo Santos, Rute Santos, Sara Santos Sanz, Jouko L Saramies, Luis B Sardinha, Nizal Sarrafzadegan, Thirunavukkarasu Sathish, Kai-Uwe Saum, Savvas Savva, Mathilde Savy, Norie Sawada, Mariana Sbaraini, Marcia Scazufca, Beatriz D Schaan, Angelika Schaffrath Rosario, Herman Schargrodsky, Anja Schienkiewitz, Sabine Schipf, Carsten O Schmidt, Ida Maria Schmidt, Peter Schnohr, Ben Schöttker, Sara Schramm, Stine Schramm, Helmut Schröder, Constance Schultsz, Aletta E Schutte, Aye Aye Sein, Rusidah Selamat, Vedrana Sember, Abhijit Sen, Idowu O Senbanjo, Sadaf G Sepanlou, Victor Sequera, Luis Serra-Majem, Jennifer Servais, Ludmila Ševcíková, Svetlana A Shalnova, Teresa Shamah-Levy, Morteza Shamshirgaran, Coimbatore Subramaniam Shanthirani, Maryam Sharafkhah, Sanjib K Sharma, Jonathan E Shaw, Amaneh Shayanrad, Ali Akbar Shayesteh, Lela Shengelia, Zumin Shi, Kenji Shibuya, Hana Shimizu-Furusawa, Dong Wook Shin, Majid Shirani, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Alfonso Siani, Rosalynn Siantar, Abla M Sibai, Antonio M Silva, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A Simons, Agneta Sjöberg, Michael Sjöström, Gry Skodje, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Hung-Kwan So, Fernanda Cunha Soares, Grzegorz Sobek, Eugène Sobngwi, Morten Sodemann, Stefan Söderberg, Moesijanti YE Soekatri, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Emily Sonestedt, Yi Song, Thorkild IA Sørensen, Elin P Sørgjerd, Charles Sossa Jérome, Victoria E Soto-Rojas, Aïcha Soumaré, Slavica Sovic, Bente Sparboe-Nilsen, Karen Sparrenberger, Angela Spinelli, Igor Spiroski, Jan A Staessen, Hanspeter Stamm, Maria G Stathopoulou, Kaspar Staub, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D Stein, George S Stergiou, Jochanan Stessman, Ranko Stevanovic, Jutta Stieber, Doris Stöckl, Tanja Stocks, Jakub Stokwiszewski, Ekaterina Stoyanova, Gareth Stratton, Karien Stronks, Maria Wany Strufaldi, Lela Sturua, Ramón Suárez-Medina, Machi Suka, Chien-An Sun, Johan Sundström, Yn-Tz Sung, Jordi Sunyer, Paibul Suriyawongpaisal, Boyd A Swinburn, Rody G Sy, Holly E Syddall, René Charles Sylva, Moyses Szklo, Lucjan Szponar, E Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Maya Tanrygulyyeva, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Jakob Tarp, Carolina B Tarqui-Mamani, Radka Taxová Braunerová, Anne Taylor, Julie Taylor, Félicité Tchibindat, William R Tebar, Grethe S Tell, Tania Tello, Yih Chung Tham, KR Thankappan, Holger Theobald, Xenophon Theodoridis, Lutgarde Thijs, Nihal Thomas, Betina H Thuesen, Lubica Tichá, Erik J Timmermans, Anne Tjonneland, Hanna K Tolonen, Janne S Tolstrup, Murat Topbas, Roman Topór-Madry, Liv Elin Torheim, María José Tormo, Michael J Tornaritis, Maties Torrent, Laura Torres-Collado, Stefania Toselli, Giota Touloumi, Pierre Traissac, Thi Tuyet-Hanh Tran, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh TH Trinh, Atul Trivedi, Lechaba Tshepo, Maria Tsigga, Shoichiro Tsugane, Azaliia M Tuliakova, Marshall K Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L Turley, Gilad Twig, Per Tynelius, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Eunice Ugel, Flora AM Ukoli, Hanno Ulmer, Belgin Unal, Zhamyila Usupova, Hannu MT Uusitalo, Nalan Uysal, Justina Vaitkeviciute, Gonzalo Valdivia, Susana Vale, Damaskini Valvi, Rob M van Dam, Johan Van der Heyden, Yvonne T van der Schouw, Koen Van Herck, Hoang Van Minh, Natasja M Van Schoor, Irene GM van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Anette Varbo, Gregorio Varela-Moreiras, Patricia Varona-Pérez, Senthil K Vasan, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Biruta Velika, Giovanni Veronesi, WM Monique Verschuren, Cesar G Victora, Giovanni Viegi, Lucie Viet, Salvador Villalpando, Paolo Vineis, Jesus Vioque, Jyrki K Virtanen, Marjolein Visser, Sophie Visvikis-Siest, Bharathi Viswanathan, Mihaela Vladulescu, Tiina Vlasoff, Dorja Vocanec, Peter Vollenweider, Henry Völzke, Ari Voutilainen, Sari Voutilainen, Martine Vrijheid, Tanja GM Vrijkotte, Alisha N Wade, Aline Wagner, Thomas Waldhör, Janette Walton, Elvis OA Wambiya, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo de Souza Wanderley Júnior, Ming-Dong Wang, Ningli Wang, Qian Wang, Xiangjun Wang, Ya Xing Wang, Ying-Wei Wang, S Goya Wannamethee, Nicholas Wareham, Adelheid Weber, Niels Wedderkopp, Deepa Weerasekera, Daniel Weghuber, Wenbin Wei, Aneta Weres, Bo Werner, Peter H Whincup, Kurt Widhalm, Indah S Widyahening, Andrzej Wiecek, Rainford J Wilks, Johann Willeit, Peter Willeit, Julianne Williams, Tom Wilsgaard, Bogdan Wojtyniak, Roy A Wong-McClure, Andrew Wong, Jyh Eiin Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C Wu, Jianfeng Wu, Li Juan Wu, Shouling Wu, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Uruwan Yamborisut, Weili Yan, Ling Yang, Xiaoguang Yang, Yang Yang, Nazan Yardim, Mehdi Yaseri, Tabara Yasuharu, Xingwang Ye, Panayiotis K Yiallouros, Moein Yoosefi, Akihiro Yoshihara, Qi Sheng You, San-Lin You, Novie O Younger-Coleman, Safiah Md Yusof, Ahmad Faudzi Yusoff, Luciana Zaccagni, Vassilis Zafiropulos, Ahmad A Zainuddin, Seyed Rasoul Zakavi, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Hana Zamrazilová, Maria Elisa Zapata, Abdul Hamid Zargar, Ko Ko Zaw, Tomasz Zdrojewski, Kristyna Zejglicova, Tajana Zeljkovic Vrkic, Yi Zeng, Luxia Zhang, Zhen-Yu Zhang, Dong Zhao, Ming-Hui Zhao, Wenhua Zhao, Shiqi Zhen, Wei Zheng, Yingfeng Zheng, Bekbolat Zholdin, Maigeng Zhou, Dan Zhu, Marie Zins, Emanuel Zitt, Yanina Zocalo, Julio Zuñiga Cisneros, Monika Zuziak, Majid Ezzati, Sarah Filippi

eLife 10 2021.3

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From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.

DOI： 10.7554/elife.60060

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身体機能低下および認知機能低下の予防に寄与する口腔関連因子の解明

濃野要, 葭原明弘, 小川祐司

日本歯科医学会誌 40 61 - 66 2021.3

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A 5-year longitudinal association between dietary fermented soya bean (natto) intake and tooth loss through bone mineral density in postmenopausal women: The Yokogoshi cohort study. International journal

Masanori Iwasaki, Misuzu Sato, Akihiro Yoshihara, Toshiko Saito, Kaori Kitamura, Toshihiro Ansai, Kazutoshi Nakamura

Gerodontology 38 ( 3 ) 267 - 275 2021.1

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OBJECTIVE: In this 5-year cohort study, we aimed to determine whether the intake of natto, a fermented soya bean food product, has an indirect effect on tooth loss incidence through BMD changes among postmenopausal women. BACKGROUND: Evidence indicates (1) that natto has a beneficial effect on bone health and (2) that a decrease in bone mineral density (BMD) is associated with tooth loss. METHODS: The study recruited 435 postmenopausal women (average age = 64.2 years). Natto intake (exposure) was assessed at baseline using a food frequency questionnaire. Lumbar spine BMD and number of teeth were measured at baseline and 5-year follow-up. BMD change (mediator) and the number of teeth lost (outcome) over time were calculated. The mediation model consisted of these 3 variables. Mediation analysis was performed to test the indirect effect of the natto intake measured through BMD change on tooth loss. RESULTS: During the study, the mean number of teeth lost was 1.2 (standard deviation = 1.8), and the mean BMD decline was 2.5% (standard deviation = 7.1). After adjusting for potential confounders, increasing habitual natto intake was significantly indirectly associated with a lower incidence of tooth loss mediated by BMD change (incidence rate ratio of tooth loss among women with "≥1 pack/day" natto intake was 0.90 [95% confidence interval = 0.82-0.99] compared to those with natto consumption of "rarely"). CONCLUSIONS: Dietary natto intake is significantly indirectly associated with a lower incidence of tooth loss among postmenopausal women, and systemic bone density could be a mediator of this association.

DOI： 10.1111/ger.12523

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Interaction between and impact of IL-6 genotype and alpha-tocopherol levels on periodontal condition in aging individuals. International journal

Akihiro Yoshihara, Noboru Kaneko, Akane Miyamoto, Kaname Nohno

Journal of periodontal research 56 ( 1 ) 139 - 146 2021.1

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BACKGROUND AND OBJECTIVES: Few studies have assessed the possible interaction between and impact of IL-6 variants and serum α-tocopherol levels on periodontal condition in older individuals. Here, we assessed the relationship between IL-6 variants and serum α-tocopherol levels on periodontal condition by considering effect modification. MATERIAL AND METHODS: Among the study participants, 359 who were 71 years of age underwent a dental examination, biochemical analysis, and interview. After dividing the participants into tertiles based on serum α-tocopherol levels, we conducted Poisson regression analysis to compare the prevalence rate ratio (PRR) for periodontal disease markers with the IL-6 genotype (rs1800796) based on each tertile adjusted by the number of teeth present (offset). RESULTS: The PRRs of the IL-6 genotype for periodontal condition (probing pocket depth [PPD], clinical attachment level [CAL], and bleeding on probing [BOP]) which were adjusted by the number of teeth present (offset) were 1.17 (P < .001), 1.37 (P < .001), and 1.08 (P = .048), respectively. In addition, a significant association was found between the reciprocal number of PRRs of the IL-6 genotype and three serum α-tocopherol levels. The adjusted PRRs (± standard error) of the IL-6 genotypes for PPD were 0.48 (0.12) for the first group (P < .001), 1.54 (0.04) for the second group (P < .001), and 2.11 (0.03) for the third group (P < .001); similar tendencies were seen for CAL and BOP. CONCLUSION: The results of this study suggest a potential association between the IL-6 genotype and periodontal condition in relation to serum antioxidant concentrations.

DOI： 10.1111/jre.12802

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Dentition status and 10-year higher-level functional capacity trajectories in older adults.

Masanori Iwasaki, Akihiro Yoshihara

Geriatrics & gerontology international 21 ( 1 ) 48 - 53 2021.1

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AIM: The effect of dentition status on higher-level functional capacity patterns over time remains unclear. We aimed to identify distinct higher-level functional capacity trajectories in individuals aged 70-80 years, and examine whether dentition status at 70 years predicted the trajectory. METHODS: The study included 551 community-dwelling adults aged 70 years at baseline. Higher-level functional capacity was measured using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) up to the age of 80 years. A higher TMIG-IC score indicated a higher level of competence. Group-based trajectory modeling was used to identify distinct TMIG-IC trajectories. The number of teeth, use of dentures, sex and education were added as baseline group membership predictors. Dental visits, health behaviors, body mass index and comorbidities during observation were added as time-varying covariates. RESULTS: Three TMIG-IC trajectories were identified: "high/stable" (65.3%), "middle/decline" (24.5%) and "low/decline" (10.2%). A lower number of teeth and non-denture use were associated with increased odds of a low/decline trajectory relative to a high/stable trajectory (odds ratio 1.09, 95% confidence interval 1.04-1.14 [per one decrease] and odds ratio 3.96, 95% confidence interval 1.54-10.16, respectively). CONCLUSIONS: Older adults with fewer teeth and those without dentures at the age of 70 years were more likely to follow a trajectory toward functional decline with low baseline TMIG-IC scores, which further declines by the age of 80 years. These findings suggest that preserving natural teeth later in life, as well as using dentures, could contribute toward maintaining a higher-level functional competence. Geriatr Gerontol Int 2021; 21: 48-53.

DOI： 10.1111/ggi.14099

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腎機能と歯の本数との関連(魚沼コホート胴査より)

皆川久美子, 葭原明弘, 諏訪間加奈, 小川祐司

口腔衛生学会雑誌 71 ( 1 ) 52 - 52 2021.1

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抗Porphyromonas gingivalis IgG血清抗体価と肝機能マーカー値および肥満との関連性佐渡コホートにおける横断研究

高見澤圭, 杉田典子, 葭原明弘, 小林哲夫, 吉江弘正, 多部田康一

新潟歯学会雑誌 50 ( 2 ) 108 - 109 2020.12

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Diet and root surface caries in a cohort of older Japanese. International journal

Akihiro Yoshihara, Kana Suwama, Akane Miyamoto, Reiko Watanabe, Hiroshi Ogawa

Community dentistry and oral epidemiology 49 ( 3 ) 301 - 308 2020.11

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OBJECTIVES: Root surface caries experience tends to increase with age. The purpose of this longitudinal study was to evaluate the relationship between aspects of dietary intake, including milk and sucrose in coffee or tea (SCT), and root surface caries in older Japanese individuals. METHODS: 303 community-dwelling older individuals (age 75 years) were enrolled for analysis. All participants underwent a dental examination at baseline and then annually from 2003 to 2008 (ie six times over a 5-year period). A disease event was considered to have occurred when root surface caries was detected on a previously sound or nonexposed root surface. Over the observation period, disease events in each year were counted. Dietary habits during the preceding month were evaluated using a brief self-administered diet history questionnaire (BDHQ) in 2003 and 2008. Poisson regression analysis performed crude and adjusted increment-rate ratios (IRRs) for root surface caries and the intake of milk and SCT. RESULTS: The adjusted increment-rate ratio (IRR) of the increment of root surface caries for participants in the highest SCT tertile was 1.72 (95%CI: 1.40-2.14) compared with the referent group. In addition, for the amount of milk intake, the adjusted IRR in the highest tertile was 0.63 (95% CI: 0.51-0.78) compared with the referent group. CONCLUSIONS: Much SCT and low milk intake were associated with the increment of root surface caries in community-dwelling older people in Japan. These findings suggest that to help prevent root surface caries, community-dwelling older people in Japan should consume adequate amounts of milk daily and limit their intake of SCT.

DOI： 10.1111/cdoe.12602

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Association between serum IgG antibody titers against Porphyromonas gingivalis and liver enzyme levels: A cross-sectional study in Sado Island. International journal

Kei Takamisawa, Noriko Sugita, Shigeki Komatsu, Minako Wakasugi, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Osamu Onodera, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie, Koichi Tabeta

Heliyon 6 ( 11 ) e05531 2020.11

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Background: Previous studies have reported associations between nonalcoholic fatty liver disease, periodontitis, and obesity. Serum immunoglobulin G (IgG) antibody titer against Porphyromonas gingivalis, a major pathogen of periodontitis, is an established indicator of periodontal infection. However, the relationship between the antibody titer and liver enzyme levels has not been clarified yet. A study in the elderly was needed to evaluate the effect of long-term persistent bacterial infection on liver function. The objective of this study was to investigate the association between liver function and infection by P. gingivalis, and the effect of obesity on the association. Methods: A cross-sectional study was conducted in adult outpatients visiting Sado General Hospital, in Niigata Prefecture, Japan, from 2008 to 2010. The final participants included 192 men and 196 women (mean age 68.1 years). Multivariable logistic regression analyses were performed to assess the association between the serum IgG antibody titer and the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamine transferase (GGT) levels. Results: In women, serum IgG antibody titers against P. gingivalis was associated with elevated ALT, but not with AST or GGT, independent of covariates (p = 0.015). No significant association was found between the antibody titer and the elevated liver enzymes in men. The effect of obesity on the relationship between antibody titer and liver enzyme levels was not statistically significant. Conclusions: A cross-sectional analysis of adult outpatients suggested an association between P. gingivalis infection and ALT levels in women. The effect of obesity on this association was not statistically significant.

DOI： 10.1016/j.heliyon.2020.e05531

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Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Andrea Rodriguez-Martinez, Bin Zhou, Marisa K Sophiea, James Bentham, Christopher J Paciorek, Maria LC Iurilli, Rodrigo M Carrillo-Larco, James E Bennett, Mariachiara Di Cesare, Cristina Taddei, Honor Bixby, Gretchen A Stevens, Leanne M Riley, Melanie J Cowan, Stefan Savin, Goodarz Danaei, Adela Chirita-Emandi, Andre P Kengne, Young-Ho Khang, Avula Laxmaiah, Reza Malekzadeh, J Jaime Miranda, Jin Soo Moon, Stevo R Popovic, Thorkild IA Sørensen, Maroje Soric, Gregor Starc, Ahmad A Zainuddin, Edward W Gregg, Zulfiqar A Bhutta, Robert Black, Leandra Abarca-Gómez, Ziad A Abdeen, Shynar Abdrakhmanova, Suhaila Abdul Ghaffar, Hanan F Abdul Rahim, Niveen M Abu-Rmeileh, Jamila Abubakar Garba, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Shoaib Afzal, Imelda A Agdeppa, Javad Aghazadeh-Attari, Carlos A Aguilar-Salinas, Charles Agyemang, Mohamad Hasnan Ahmad, Noor Ani Ahmad, Ali Ahmadi, Naser Ahmadi, Soheir H Ahmed, Wolfgang Ahrens, Gulmira Aitmurzaeva, Kamel Ajlouni, Hazzaa M Al-Hazzaa, Amani Rashed Al-Othman, Rajaa Al-Raddadi, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Mohamed M Ali, Abdullah Alkandari, Ala'a Alkerwi, Kristine Allin, Mar Alvarez-Pedrerol, Eman Aly, Deepak N Amarapurkar, Parisa Amiri, Norbert Amougou, Philippe Amouyel, Lars Bo Andersen, Sigmund A Anderssen, Lars Ängquist, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E Arku, Nimmathota Arlappa, Krishna K Aryal, Thor Aspelund, Felix K Assah, Maria Cecília F Assunção, May Soe Aung, Juha Auvinen, Mária Avdicová, Ana Azevedo, Mohsen Azimi-Nezhad, Fereidoun Azizi, Mehrdad Azmin, Bontha V Babu, Maja Bæksgaard Jørgensen, Azli Baharudin, Suhad Bahijri, Jennifer L Baker, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R Banegas, Joanna Baran, Carlo M Barbagallo, Alberto Barceló, Amina Barkat, Aluisio JD Barros, Mauro Virgílio Gomes Barros, Abdul Basit, Joao Luiz D Bastos, Iqbal Bata, Anwar M Batieha, Rosangela L Batista, Zhamilya Battakova, Assembekov Batyrbek, Louise A Baur, Robert Beaglehole, Silvia Bel-Serrat, Antonisamy Belavendra, Habiba Ben Romdhane, Judith Benedics, Mikhail Benet, James E Bennett, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloísa Bettiol, Jorge Bezerra, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K Bhargava, Zulfiqar A Bhutta, Hongsheng Bi, Yufang Bi, Daniel Bia, Elysée Claude Bika Lele, Mukharram M Bikbov, Bihungum Bista, Dusko J Bjelica, Peter Bjerregaard, Espen Bjertness, Marius B Bjertness, Cecilia Björkelund, Katia V Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Lynne M Boddy, Bernhard O Boehm, Heiner Boeing, Jose G Boggia, Elena Bogova, Carlos P Boissonnet, Stig E Bojesen, Marialaura Bonaccio, Vanina Bongard, Alice Bonilla-Vargas, Matthias Bopp, Herman Borghs, Pascal Bovet, Lien Braeckevelt, Lutgart Braeckman, Marjolijn CE Bragt, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, João Breda, Hermann Brenner, Lizzy M Brewster, Garry R Brian, Lacramioara Brinduse, Sinead Brophy, Graziella Bruno, H Bas Bueno-de-Mesquita, Anna Bugge, Marta Buoncristiano, Genc Burazeri, Con Burns, Antonio Cabrera de León, Joseph Cacciottolo, Hui Cai, Tilema Cama, Christine Cameron, José Camolas, Günay Can, Ana Paula C Cândido, Felicia Cañete, Mario V Capanzana, Nadežda Capková, Eduardo Capuano, Vincenzo Capuano, Marloes Cardol, Viviane C Cardoso, Axel C Carlsson, Esteban Carmuega, Joana Carvalho, José A Casajús, Felipe F Casanueva, Ertugrul Celikcan, Laura Censi, Marvin Cervantes-Loaiza, Juraci A Cesar, Snehalatha Chamukuttan, Angelique W Chan, Queenie Chan, Himanshu K Chaturvedi, Nish Chaturvedi, Norsyamlina Che Abdul Rahim, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Bahman Cheraghian, Angela Chetrit, Ekaterina Chikova-Iscener, Arnaud Chiolero, Shu-Ti Chiou, Adela Chirita-Emandi, María-Dolores Chirlaque, Belong Cho, Kaare Christensen, Diego G Christofaro, Jerzy Chudek, Renata Cifkova, Michelle Cilia, Eliza Cinteza, Frank Claessens, Janine Clarke, Els Clays, Emmanuel Cohen, Hans Concin, Susana C Confortin, Cyrus Cooper, Tara C Coppinger, Eva Corpeleijn, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L Craig, Amelia C Crampin, Ana B Crujeiras, Semánová Csilla, Alexandra M Cucu, Liufu Cui, Felipe V Cureau, Graziella D'Arrigo, Eleonora d'Orsi, Liliana Dacica, María Ángeles Dal Re Saavedra, Jean Dallongeville, Albertino Damasceno, Camilla T Damsgaard, Goodarz Danaei, Rachel Dankner, Thomas M Dantoft, Parasmani Dasgupta, Saeed Dastgiri, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, David De Ridder, Karin De Ridder, Susanne R de Rooij, Delphine De Smedt, Mohan Deepa, Alexander D Deev, Vincent Jr DeGennaro, Abbas Dehghan, Hélène Delisle, Francis Delpeuch, Stefaan Demarest, Elaine Dennison, Katarzyna Deren, Valérie Deschamps, Klodian Dhana, Meghnath Dhimal, Augusto F Di Castelnuovo, Juvenal Soares Dias-da-Costa, María Elena Díaz-Sánchez, Alejandro Diaz, Zivka Dika, Shirin Djalalinia, Visnja Djordjic, Ha TP Do, Annette J Dobson, Maria Benedetta Donati, Chiara Donfrancesco, Silvana P Donoso, Angela Döring, Maria Dorobantu, Ahmad Reza Dorosty, Kouamelan Doua, Wojciech Drygas, Jia Li Duan, Charmaine A Duante, Priscilla Duboz, Rosemary B Duda, Vesselka Duleva, Virginija Dulskiene, Samuel C Dumith, Anar Dushpanova, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Ricky Eddie, Ebrahim Eftekhar, Eruke E Egbagbe, Robert Eggertsen, Sareh Eghtesad, Gabriele Eiben, Ulf Ekelund, Mohammad El-Khateeb, Jalila El Ati, Denise Eldemire-Shearer, Marie Eliasen, Paul Elliott, Reina Engle-Stone, Macia Enguerran, Rajiv T Erasmus, Raimund Erbel, Cihangir Erem, Louise Eriksen, Johan G Eriksson, Jorge Escobedo-de la Peña, Saeid Eslami, Ali Esmaeili, Alun Evans, David Faeh, Albina A Fakhretdinova, Caroline H Fall, Elnaz Faramarzi, Mojtaba Farjam, 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The Lancet 396 ( 10261 ) 1511 - 1524 2020.11

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Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/s0140-6736(20)31859-6

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Publishing type：Research paper (scientific journal)

DOI： 10.3390/APP10186450

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Repositioning of the global epicentre of non-optimal cholesterol

Cristina Taddei, Bin Zhou, Honor Bixby, Rodrigo M. Carrillo-Larco, Goodarz Danaei, Rod T. Jackson, Farshad Farzadfar, Marisa K. Sophiea, Mariachiara Di Cesare, Maria Laura Caminia Iurilli, Andrea Rodriguez Martinez, Golaleh Asghari, Klodian Dhana, Pablo Gulayin, Sujay Kakarmath, Marilina Santero, Trudy Voortman, Leanne M. Riley, Melanie J. Cowan, Stefan Savin, James E. Bennett, Gretchen A. Stevens, Christopher J. Paciorek, Wichai Aekplakorn, Renata Cifkova, Simona Giampaoli, Andre Pascal Kengne, Young-Ho Khang, Kari Kuulasmaa, Avula Laxmaiah, Paula Margozzini, Prashant Mathur, Børge G. Nordestgaard, Dong Zhao, Mette Aadahl, Leandra Abarca-Gómez, Hanan Abdul Rahim, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J. Adams, Imelda A. Agdeppa, Javad Aghazadeh-Attari, Carlos A. Aguilar-Salinas, Charles Agyemang, Tarunveer S. Ahluwalia, Noor Ani Ahmad, Ali Ahmadi, Naser Ahmadi, Soheir H. Ahmed, Wolfgang Ahrens, Kamel Ajlouni, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Mohamed M. Ali, Abdullah Alkandari, Ala’a Alkerwi, Eman Aly, Deepak N. Amarapurkar, Philippe Amouyel, Lars Bo Andersen, Sigmund A. Anderssen, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E. Arku, Nimmathota Arlappa, Krishna K. Aryal, Thor Aspelund, Maria Cecília F. Assunção, Juha Auvinen, Mária Avdicová, Ana Azevedo, Fereidoun Azizi, Mehrdad Azmin, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R. Banegas, Carlo M. Barbagallo, Alberto Barceló, Amina Barkat, Iqbal Bata, Anwar M. Batieha, Assembekov Batyrbek, Louise A. Baur, Robert Beaglehole, Antonisamy Belavendra, Habiba Ben Romdhane, Mikhail Benet, Marianne Benn, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloisa Bettiol, Santosh K. Bhargava, Yufang Bi, Asako Bienek, Mukharram Bikbov, Bihungum Bista, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Björkelund, Katia V. Bloch, Anneke Blokstra, Simona Bo, Bernhard O. Boehm, Jose G. Boggia, Carlos P. Boissonnet, Marialaura Bonaccio, Vanina Bongard, Rossana Borchini, Herman Borghs, Pascal Bovet, Imperia Brajkovich, Juergen Breckenkamp, Hermann Brenner, Lizzy M. Brewster, Graziella Bruno, Anna Bugge, Markus A. Busch, Antonio Cabrera de León, Joseph Cacciottolo, Günay Can, Ana Paula C. Cândido, Mario V. Capanzana, Eduardo Capuano, Vincenzo Capuano, Viviane C. Cardoso, Joana Carvalho, Felipe F. Casanueva, Laura Censi, Charalambos A. Chadjigeorgiou, Snehalatha Chamukuttan, Nish Chaturvedi, Chien-Jen Chen, Fangfang Chen, Shuohua Chen, Ching-Yu Cheng, Bahman Cheraghian, Angela Chetrit, Shu-Ti Chiou, María-Dolores Chirlaque, Belong Cho, Yumi Cho, Jerzy Chudek, Frank Claessens, Janine Clarke, Els Clays, Hans Concin, Susana C. Confortin, Cyrus Cooper, Simona Costanzo, Dominique Cottel, Chris Cowell, Ana B. Crujeiras, Semánová Csilla, Liufu Cui, Felipe V. Cureau, Graziella D’Arrigo, Eleonora d’Orsi, Jean Dallongeville, Albertino Damasceno, Rachel Dankner, Thomas M. Dantoft, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, David De Ridder, Delphine De Smedt, Mohan Deepa, Alexander D. Deev, Abbas Dehghan, Hélène Delisle, Elaine Dennison, Valérie Deschamps, Meghnath Dhimal, Augusto F. Di Castelnuovo, Zivka Dika, Shirin Djalalinia, Annette J. Dobson, Chiara Donfrancesco, Silvana P. Donoso, Angela Döring, Maria Dorobantu, Nico Dragano, Wojciech Drygas, Yong Du, Charmaine A. Duante, Rosemary B. Duda, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Ricky Eddie, Ebrahim Eftekhar, Robert Eggertsen, Sareh Eghtesad, Gabriele Eiben, Ulf Ekelund, Jalila El Ati, Denise Eldemire-Shearer, Marie Eliasen, Roberto Elosua, Rajiv T. Erasmus, Raimund Erbel, Cihangir Erem, Louise Eriksen, Johan G. Eriksson, Jorge Escobedo-de la Peña, Saeid Eslami, Ali Esmaeili, Alun Evans, David Faeh, Caroline H. Fall, Elnaz Faramarzi, Mojtaba Farjam, Mohammad Reza Fattahi, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernández-Bergés, Daniel Ferrante, Marika Ferrari, Catterina Ferreccio, Jean Ferrieres, Bernhard Föger, Leng Huat Foo, Ann-Sofie Forslund, Maria Forsner, Heba M. Fouad, Damian K. Francis, Maria do Carmo Franco, Oscar H. Franco, Guillermo Frontera, Yuki Fujita, Matsuda Fumihiko, Takuro Furusawa, Zbigniew Gaciong, Fabio Galvano, Jingli Gao, Manoli Garcia-de-la-Hera, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Andrea Gazzinelli, Johanna M. Geleijnse, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Anup Ghimire, Francesco Gianfagna, Tiffany K. Gill, Jonathan Giovannelli, Glen Gironella, Aleksander Giwercman, David Goltzman, Helen Gonçalves, David A. Gonzalez-Chica, Marcela Gonzalez-Gross, Juan P. González-Rivas, Clicerio González-Villalpando, María-Elena González-Villalpando, Angel R. Gonzalez, Frederic Gottrand, Sidsel Graff-Iversen, Dušan Grafnetter, Ronald D. Gregor, Tomasz Grodzicki, Anders Grøntved, Giuseppe Grosso, Gabriella Gruden, Dongfeng Gu, Pilar Guallar-Castillón, Ong Peng Guan, Elias F. Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Johanna Gunnlaugsdottir, Rajeev Gupta, Laura Gutierrez, Felix Gutzwiller, Seongjun Ha, Farzad Hadaegh, Rosa Haghshenas, Hamid Hakimi, Ian R. Hambleton, Behrooz Hamzeh, Sari Hantunen, Rachakulla Hari Kumar, Seyed Mohammad Hashemi-Shahri, Jun Hata, Teresa Haugsgjerd, Alison J. Hayes, Jiang He, Yuna He, Marleen Elisabeth Hendriks, Ana Henriques, Sauli Herrala, Ramin Heshmat, Allan G. Hill, Sai Yin Ho, Suzanne C. Ho, Michael Hobbs, Albert Hofman, Reza Homayounfar, Wilma M. Hopman, Andrea R. V. R. Horimoto, Claudia M. Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, José María Huerta, Ilpo Tapani Huhtaniemi, Martijn Huisman, Monica L. Hunsberger, Abdullatif S. Husseini, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G. Iannone, Mohsen M. Ibrahim, Norazizah Ibrahim Wong, Iris Iglesia, Nayu Ikeda, M. Arfan Ikram, Violeta Iotova, Vilma E. Irazola, Takafumi Ishida, Muhammad Islam, Aziz al-Safi Ismail, Masanori Iwasaki, Jeremy M. Jacobs, Hashem Y. Jaddou, Tazeen Jafar, Kenneth James, Konrad Jamrozik, Imre Janszky, Edward Janus, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelakovic, Bojan Jelakovic, Garry Jennings, Gorm B. Jensen, Seung-lyeal Jeong, Anjani Kumar Jha, Chao Qiang Jiang, Ramon O. Jimenez, Karl-Heinz Jöckel, Michel Joffres, Jari J. Jokelainen, Jost B. Jonas, Torben Jørgensen, Pradeep Joshi, Farahnaz Joukar, Jacek Józwiak, Anne Juolevi, Anthony Kafatos, Eero O. Kajantie, Ofra Kalter-Leibovici, Nor Azmi Kamaruddin, Pia R. Kamstrup, Khem B. Karki, Joanne Katz, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli Kazakbaeva, Ulrich Keil, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Maryam Keramati, Alina Kerimkulova, Mathilde Kersting, Yousef Saleh Khader, Davood Khalili, Mohammad Khateeb, Motahareh Kheradmand, Alireza Khosravi, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Japhet Killewo, Hyeon Chang Kim, Jeongseon Kim, Yeon-Yong Kim, Jurate Klumbiene, Michael Knoflach, Stephanie Ko, Hans-Peter Kohler, Iliana V. Kohler, Elin Kolle, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Jelena Kos, Seppo Koskinen, Katsuyasu Kouda, Sudhir Kowlessur, Wolfgang Kratzer, Susi Kriemler, Peter Lund Kristensen, Steiner Krokstad, Daan Kromhout, Urho M. Kujala, Pawel Kurjata, Catherine Kyobutungi, Fatima Zahra Laamiri, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Christina-Paulina Lambrinou, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Lars E. Laugsand, Maria Lazo-Porras, Jeannette Lee, Jeonghee Lee, Nils Lehmann, Terho Lehtimäki, Naomi S. Levitt, Yanping Li, Christa L. Lilly, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Yi-Ting Lin, Lars Lind, Allan Linneberg, Lauren Lissner, Jing Liu, Helle-Mai Loit, Esther Lopez-Garcia, Tania Lopez, Paulo A. Lotufo, José Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Nuno Lunet, Guansheng Ma, George L. L. Machado-Coelho, Aristides M. Machado-Rodrigues, Suka Machi, Ahmed A. Madar, Stefania Maggi, Dianna J. Magliano, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marcia Makdisse, Fatemeh Malekzadeh, Reza Malekzadeh, Kodavanti Mallikharjuna Rao, Yannis Manios, Jim I. Mann, Fariborz Mansour-Ghanaei, Enzo Manzato, Pedro Marques-Vidal, Reynaldo Martorell, Luis P. Mascarenhas, Ellisiv B. Mathiesen, Tandi E. Matsha, Christina Mavrogianni, Shelly R. McFarlane, Stephen T. McGarvey, Stela McLachlan, Rachael M. McLean, Scott B. McLean, Breige A. McNulty, Sounnia Mediene-Benchekor, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Christa Meisinger, Ana Maria B. Menezes, Geetha R. Menon, Shahin Merat, Alibek Mereke, Indrapal I. Meshram, Patricia Metcalf, Haakon E. Meyer, Jie Mi, Nathalie Michels, Jody C. Miller, Cláudia S. Minderico, G. K. Mini, Juan Francisco Miquel, J. Jaime Miranda, Mohammad Reza Mirjalili, Erkin Mirrakhimov, Pietro A. Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K. Mohamed, Kazem Mohammad, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Farnam Mohebi, Marie Moitry, Line T. Møllehave, Niels C. Møller, Dénes Molnár, Amirabbas Momenan, Charles K. Mondo, Eric Monterrubio-Flores, Mahmood Moosazadeh, Alain Morejon, Luis A. Moreno, Karen Morgan, Suzanne N. Morin, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Kelias P. Msyamboza, Maria L. Muiesan, Martina Müller-Nurasyid, Jaakko Mursu, Norlaila Mustafa, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Balkish M. Naidu, Farid Najafi, Harunobu Nakamura, Jana Námešná, Ei Ei K. Nang, Vinay B. Nangia, Matthias Nauck, William A. Neal, Azim Nejatizadeh, Ilona Nenko, Flavio Nervi, Nguyen D. Nguyen, Quang Ngoc Nguyen, Ramfis E. Nieto-Martínez, Thomas Nihal, Teemu J. Niiranen, Guang Ning, Toshiharu Ninomiya, Marianna Noale, Oscar A. Noboa, Davide Noto, Mohannad Al Nsour, Irfan Nuhoğlu, Terence W. O’Neill, Dermot O’Reilly, Angélica M. Ochoa-Avilés, Kyungwon Oh, Ryutaro Ohtsuka, Örn Olafsson, Valérie Olié, Isabel O. Oliveira, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Pedro Ordunez, Rui Ornelas, Pedro J. Ortiz, Clive Osmond, Sergej M. Ostojic, Afshin Ostovar, Johanna A. Otero, Ellis Owusu-Dabo, Fred Michel Paccaud, Elena Pahomova, Andrzej Pajak, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Winsome R. Parnell, Nikhil D. Patel, Nasheeta Peer, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Niloofar Peykari, Son Thai Pham, Rafael N. Pichardo, Iris Pigeot, Aida Pilav, Lorenza Pilotto, Aleksandra Piwonska, Andreia N. Pizarro, Pedro Plans-Rubió, Silvia Plata, Hermann Pohlabeln, Miquel Porta, Marileen L. P. Portegies, Anil Poudyal, Farhad Pourfarzi, Hossein Poustchi, Rajendra Pradeepa, Jacqueline F. Price, Rui Providencia, Jardena J. Puder, Soile E. Puhakka, Margus Punab, Mostafa Qorbani, Tran Quoc Bao, Ricardas Radisauskas, Salar Rahimikazerooni, Olli Raitakari, Sudha Ramachandra Rao, Ambady Ramachandran, Elisabete Ramos, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Josep Redon, Paul Ferdinand M. Reganit, Luis Revilla, Abbas Rezaianzadeh, Robespierre Ribeiro, Adrian Richter, Fernando Rigo, Tobias F. Rinke de Wit, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A. Rodríguez-Villamizar, Ulla Roggenbuck, Rosalba Rojas-Martinez, Dora Romaguera, Elisabetta L. Romeo, Annika Rosengren, Joel G. R. Roy, Adolfo Rubinstein, Jean-Bernard Ruidavets, Blanca Sandra Ruiz-Betancourt, Paola Russo, Petra Rust, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S. Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Saeid Safiri, Olfa Saidi, Nader Saki, Benoit Salanave, Diego Salmerón, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Jose Sánchez-Abanto, Susana Sans, Alba M. Santaliestra-Pasías, Diana A. Santos, Maria Paula Santos, Rute Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Savvas C. Savva, Norie Sawada, Mariana Sbaraini, Marcia Scazufca, Beatriz D. Schaan, Herman Schargrodsky, Christa Scheidt-Nave, Anja Schienkiewitz, Sabine Schipf, Carsten O. Schmidt, Ben Schöttker, Sara Schramm, Sylvain Sebert, Aye Aye Sein, Abhijit Sen, Sadaf G. Sepanlou, Jennifer Servais, Ramin Shakeri, Svetlana A. Shalnova, Teresa Shamah-Levy, Maryam Sharafkhah, Sanjib K. Sharma, Jonathan E. Shaw, Amaneh Shayanrad, Zumin Shi, Kenji Shibuya, Hana Shimizu-Furusawa, Dong Wook Shin, Youchan Shin, Majid Shirani, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Alfonso Siani, Rosalynn Siantar, Abla M. Sibai, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjöström, Tea Skaaby, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Marieke B. Snijder, Stefan Söderberg, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Emily Sonestedt, Thorkild I. A. Sørensen, Charles Sossa Jérome, Aïcha Soumaré, Kaan Sozmen, Karen Sparrenberger, Jan A. Staessen, Maria G. Stathopoulou, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, Jochanan Stessman, Ranko Stevanović, Jutta Stieber, Doris Stöckl, Jakub Stokwiszewski, Karien Stronks, Maria Wany Strufaldi, Ramón Suárez-Medina, Chien-An Sun, Johan Sundström, Paibul Suriyawongpaisal, Rody G. Sy, René Charles Sylva, Moyses Szklo, E. Shyong Tai, Abdonas Tamosiunas, Eng Joo Tan, Mohammed Rasoul Tarawneh, Carolina B. Tarqui-Mamani, Anne Taylor, Julie Taylor, Grethe S. Tell, Tania Tello, K. R. Thankappan, Lutgarde Thijs, Betina H. Thuesen, Ulla Toft, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Roman Topór-Madry, María José Tormo, Michael J. Tornaritis, Maties Torrent, Laura Torres-Collado, Pierre Traissac, Oanh T. H. Trinh, Julia Truthmann, Shoichiro Tsugane, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Christophe Tzourio, Peter Ueda, Eunice Ugel, Hanno Ulmer, Belgin Unal, Hannu M. T. Uusitalo, Gonzalo Valdivia, Damaskini Valvi, Rob M. van Dam, Yvonne T. van der Schouw, Koen Van Herck, Hoang Van Minh, Lenie van Rossem, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Anette Varbo, Patricia Varona-Pérez, Senthil K. Vasan, Lars Vatten, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Silvia J. Venero-Fernández, Giovanni Veronesi, W. M. Monique Verschuren, Cesar G. Victora, Dhanasari Vidiawati, Lucie Viet, Salvador Villalpando, Jesus Vioque, Jyrki K. Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Tiina Vlasoff, Peter Vollenweider, Ari Voutilainen, Alisha N. Wade, Aline Wagner, Janette Walton, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Ming-Dong Wang, Ningli Wang, Qian Wang, Ya Xing Wang, Ying-Wei Wang, S. Goya Wannamethee, Niels Wedderkopp, Wenbin Wei, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Wiecek, Alet H. Wijga, Rainford J. Wilks, Johann Willeit, Peter Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Roy A. Wong-McClure, Andrew Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C. Wu, Shouling Wu, Haiquan Xu, Liang Xu, Weili Yan, Xiaoguang Yang, Tabara Yasuharu, Xingwang Ye, Toh Peng Yeow, Panayiotis K. Yiallouros, Moein Yoosefi, Akihiro Yoshihara, San-Lin You, Novie O. Younger-Coleman, Ahmad Faudzi Yusoff, Ahmad A. Zainuddin, Seyed Rasoul Zakavi, Mohammad Reza Zali, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Ko Ko Zaw, Tomasz Zdrojewski, Tajana Zeljkovic Vrkic, Zhen-Yu Zhang, Wenhua Zhao, Shiqi Zhen, Yingfeng Zheng, Bekbolat Zholdin, Baurzhan Zhussupov, Nada Zoghlami, Julio Zuñiga Cisneros, Edward W. Gregg, Majid Ezzati, NCD Risk Factor Collaboration (NCD-RisC)

Nature 582 ( 7810 ) 73 - 77 2020.6

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Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Research

DOI： 10.1038/s41586-020-2338-1

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血中肝機能マーカーと抗Porphyromonas gingivalis抗体価の関連性

杉田典子, 高見澤圭, 葭原明弘, 小林哲夫, 吉江弘正, 多部田康一

特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集 152回 148 - 148 2020.6

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Language：Japanese Publisher：(NPO)日本歯科保存学会

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小児の口唇閉鎖力と口腔内を含む関連要因の研究口唇閉鎖習慣と姿勢

諏訪間加奈, 野上有紀子, 葭原明弘

小児歯科学雑誌 58 ( 大会抄録(誌上開催)号 ) 95 - 95 2020.4

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Language：Japanese Publisher：(公社)日本小児歯科学会

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The relationship between sucrose intake in coffee or tea, and root or coronal caries in an elderly Japanese population. Reviewed International journal

A Yoshihara, K Suwama, A Miyamoto, R Watanabe, H Ogawa

Community dental health 2020.3

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Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: Few studies have examined the effect of sucrose intake in coffee or tea (SCT) on dental caries, especially root caries, in elderly people. The purpose of the present study was to examine the associations between SCT and the prevalence of root or coronal caries in community-dwelling elderly Japanese. METHODS: Participants were 370 elders aged 75 years from a larger cohort study of elders in Niigata City, Japan. Dietary habits during the preceding month were assessed with a validated brief self-administered diet history questionnaire (BDHQ). The caries examination was conducted using mirror and ball-pointed periodontal probes under artificial light. Poisson regression analysis was performed to analyze the prevalence-rate ratios (PRRs) between SCT and the root or coronal caries. The number of root or coronal caries was selected as the dependent variable for the analysis. Then, SCT (tertiles labeled low, medium and high) and other 4 variables were selected as independent variables. RESULTS: The PRRs between the number of root caries lesions and SCT were signifi cantly higher in the second (medium intake, 1.38, p ⟨ 0.001) and third tertiles (high intake, 2.07, p ⟨ 0.001). Similar tendencies were seen for the number of coronal caries lesions (PRRs in the second and third tertiles 1.74 and 2.46, respectively, both p ⟨ 0.001). CONCLUSION: A significant positive relationship was observed between sucrose in coffee and tea and the number of coronal or root caries lesions in community-dwelling elderly Japanese.

DOI： 10.1922/CDH_00011Yoshihara05

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乳歯における癒合歯および形成不全とその原因についての臨床的考察

宮本茜, 葭原明弘, 皆川久美子, 金子昇, 濃野要, 市川優, 星野剛志, 藤山友紀, 平野真弓, 小川祐司

口腔衛生学会雑誌 70 ( 増刊 ) 106 - 106 2020.3

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Language：Japanese Publisher：(一社)日本口腔衛生学会

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National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries Reviewed

Cristina Taddei, Rod Jackson, Bin Zhou, Honor Bixby, Goodarz Danaei, Mariachiara Di Cesare, Kari Kuulasmaa, Kaveh Hajifathalian, James Bentham, James E Bennett, Wichai Aekplakorn, Renata Cifkova, Jean Dallongeville, Dirk DeBacquer, Simona Giampaoli, Vilmundur Gudnason, Young-Ho Khang, Tiina Laatikainen, JimI Mann, Pedro Marques-Vidal, George A Mensah, Martina Müller-Nurasyid, Toshiharu Ninomiya, Janina Petkeviciene, Fernando Rodríguez-Artalejo, Jennifer Servais, Stefan Söderberg, Bill Stavreski, Tom Wilsgaard, Tomasz Zdrojewski, Dong Zhao, Gretchen A Stevens, Stefan Savin, Melanie J Cowan, Leanne M Riley, Majid Ezzati, Robert J Adams, Wichai Aekplakorn, Wolfgang Ahrens, Philippe Amouyel, Antoinette Amuzu, Sigmund A Anderssen, Inger Ariansen, Dominique Arveiler, Thor Aspelund, Juha Auvinen, Mária Avdicová, Maciej Banach, Piotr Bandosz, José R Banegas, Carlo M Barbagallo, Iqbal Bata, Louise A Baur, Robert Beaglehole, James E Bennett, Gailute Bernotiene, Yufang Bi, Asako Bienek, Cecilia Björkelund, Simona Bo, Bernhard O Boehm, Marialaura Bonaccio, Vanina Bongard, Rossana Borchini, Herman Borghs, Juergen Breckenkamp, Hermann Brenner, Graziella Bruno, Markus A Busch, Antonio Cabrera de León, Vincenzo Capuano, Felipe F Casanueva, Juan-Pablo Casas, Carmelo A Caserta, Laura Censi, Fangfang Chen, Shuohua Chen, María-Dolores Chirlaque, Belong Cho, Yumi Cho, Jerzy Chudek, Renata Cifkova, Frank Claessens, Janine Clarke, Els Clays, Cyrus Cooper, Simona Costanzo, Dominique Cottel, Chris Cowell, Ana B Crujeiras, Liufu Cui, Graziella D'Arrigo, Jean Dallongeville, Luc Dauchet, Guy De Backer, Dirk De Bacquer, Giovanni de Gaetano, Stefaan De Henauw, Delphine De Smedt, Elaine Dennison, Valérie Deschamps, Augusto DiCastelnuovo, Annette J Dobson, Chiara Donfrancesco, Angela Döring, Wojciech Drygas, Yong Du, Elzbieta Dziankowska-Zaborszczyk, Robert Eggertsen, Ulf Ekelund, Roberto Elosua, Johan G Eriksson, Alun Evans, David Faeh, Francisco J Felix-Redondo, Daniel Fernández-Bergés, Marika Ferrari, Jean Ferrieres, Joseph D Finn, Ann-Sofie Forslund, Maria Forsner, Guillermo Frontera, Yuki Fujita, Zbigniew Gaciong, Fabio Galvano, Jingli Gao, Manoli Garcia-de-la-Hera, Sarah P Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Simona Giampaoli, Francesco Gianfagna, Tiffany K Gill, Jonathan Giovannelli, David Goltzman, Marcela GonzalezGross, Frederic Gottrand, Sidsel Graff-Iversen, Dušan Grafnetter, Ronald D Gregor, Tomasz Grodzicki, Giuseppe Grosso, Grabriella Gruden, Dongfeng Gu, Pilar Guallar-Castillón, Elias F Gudmundsson, Vilmundur Gudnason, Idris Guessous, Johanna Gunnlaugsdottir, Felix Gutzwiller, Rebecca Hardy, Jun Hata, Teresa Haugsgjerd, Alison J Hayes, Jiang He, Yuna He, Sauli Herrala, Ilpo TapaniHihtaniemi, Michael Hobbs, Wilma M Hopman, José MaríaHuerta, Inge Huybrechts, Licia Iacoviello, Anna G Iannone, Nayu Ikeda, Masanori Iwasaki, Rod Jackson, Konrad Jamrozik, Imre Janszky, Marjo-Riitta Jarvelin, Grazyna Jasienska, Garry Jennings, Seung-lyeal Jeong, Chao QiangJiang, Michel Joffres, Jari J Jokelainen, Jost B Jonas, Jacek Jóźwiak, Eero O Kajantie, Jussi Kauhanen, Ulrich Keil, Sirkka Keinänen-Kiukaanniemi, Mathilde Kersting, Young-Ho Khang, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Jeongseon Kim, Yeon-Yong Kim, Jurate Klumbiene, Michael Knoflach, Stephanie Ko, Elin Kolle, Raija Korpelainen, Seppo Koskinen, Katsuyasu Kouda, Wolfgang Kratzer, Susi Kriemler, Steinar Krokstad, Urho M Kujala, Pawel Kurjata, Kari Kuulasmaa, Tiina Laatikainen, Tai HingLam, Vera Lanska, Georg Lappas, Lars E Laugsand, Jeonghee Lee, Terho Lehtimäki, Yanping Li, Christa L Lilly, Xu Lin, Lars Lind, Lauren Lissner, Jing Liu, Esther Lopez-Garcia, Roberto Lorbeer, José EugenioLozano, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Per Lytsy, Guansheng Ma, Suka Machi, Stefania Maggi, Dianna J Magliano, JimI Mann, Enzo Manzato, Pedro Marques-Vidal, Ellisiv B Mathiesen, Stela McLachlan, Rachael M McLean, Scott B McLean, Aline Meirhaeghe, Christa Meisinger, Patricia Metcalf, Jie Mi, Jody C Miller, Luis A Moreno, Suzanne Morin, Malgorzata Mossakowska, Maria L Muiesan, Martina Müller-Nurasyid, Jaakko Mursu, Harunobu Nakamura, Jana Námešná, Matthias Nauck, Eva MariaNavarrete-Muñoz, William A Neal, Ilona Nenko, Teemu J Niiranen, Guang Ning, Toshiharu Ninomiya, Marianna Noale, Sawada Norie, Davide Noto, Terence O'Neill, Dermot O'Reilly, Kyungwon Oh, Örn Olafsson, Fred MichelPaccaud, Andrzej Pajak, Luigi Palmieri, Francesco Panza, Winsome R Parnell, Markku Peltonen, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Iris Pigeot, Lorenza Pilotto, Aleksandra Piwonska, Pedro Plans-Rubió, Miquel Porta, Jacqueline F Price, Jardena J Puder, Soile E Puhakka, Ricardas Radisauskas, Olli Raitakari, Rafel Ramos, Josep Redon, Fernando Rigo, Fernando Rodríguez-Artalejo, MaríadelCristo Rodriguez-Perez, Dora Romaguera, Kimmo Ronkainen, Annika Rosengren, Joel G R Roy, Jean-Bernard Ruidavets, Marcin Rutkowski, Benoit Salanave, Diego Salmerón, Veikko Salomaa, Jukka T Salonen, Massimo Salvetti, Susana Sans, Jouko L Saramies, Kai-Uwe Saum, Christa Scheidt-Nave, Anja Schienkiewitz, Sabine Schipf, Carsten O Schmidt, Ben Schöttker, Sylvain Sebert, Abhijit Sen, Jennifer Servais, Jonathan E Shaw, Kenji Shibuya, Dong WookShin, Rahman Shiri, Judith Simons, Leon A Simons, Michael Sjöström, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Stefan Söderberg, Vincenzo Solfrizzi, Emily Sonestedt, Aicha Soumare, Jan A Staessen, Maria G Stathopoulou, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Jutta Stieber, Doris Stöckl, Jakub Stokwiszewski, Johan Sundström, Paibul Suriyawongpaisal, Abdonas Tamosiunas, Eng JooTan, Anne Taylor, Grethe Tell, Lutgarde Thijs, HannaK Tolonen, Roman Topór-Madry, María JoséTormo, Maties Torrent, Shoichiro Tsugane, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Christophe Tzourio, Hannu M T Uusitalo, Koen Van Herck, Dirk Vanderschueren, Diego Vanuzzo, Lars Vatten, Tomas Vega, Giovanni Veronesi, Jesus Vioque, JyrkiK Virtanen, Sophie Visvikis-Siest, Peter Vollenweider, Sari Voutilainen, Martine Vrijheid, Aline Wagner, Anne Wagner, Ming-Dong Wang, Qian Wang, Ya XingWang, S Goya Wannamethee, Wenbin Wei, Peter H Whincup, Andrzej Wiecek, Johann Willeit, Peter Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Andrew Wong, Mark Woodward, Aleksander GiwercmanWu, Frederick C Wu, Shouling Wu, Haiquan Xu, Liang Xu, Weili Yan, Xiaoguang Yang, Xingwang Ye, Akihiro Yoshihara, Sabina Zambon, Tomasz Zdrojewski, Dong Zhao, Wenhua Zhao

International Journal of Epidemiology 49 ( 1 ) 173 - 192 2020.2

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Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

<title>Abstract</title>
<sec>
<title>Background</title>
Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries.

</sec>
<sec>
<title>Methods</title>
We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group.

</sec>
<sec>
<title>Results</title>
Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China.

</sec>
<sec>
<title>Conclusions</title>
HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.

</sec>

DOI： 10.1093/ije/dyz099

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学童期における唾液中乳酸脱水素酵素とストレスの関連について Reviewed

田村浩平, 葭原明弘, 諏訪間加奈, 角田聡子, 岩崎正則, 安細敏弘, 小川祐司

口腔衛生学会雑誌 70 ( 1 ) 47 - 48 2020.1

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腎機能低下と口腔健康状態の関連について Reviewed

諏訪間加奈, 金子昇, 星野剛志, 葭原明弘

口腔衛生学会雑誌 70 ( 1 ) 47 - 47 2020.1

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歯肉自己観察の歯周病スクリーニングにおける有用性

市川優, 葭原明弘, 山田智子, 杉本智子, 林悠子, 皆川久美子, 小川祐司

口腔衛生学会雑誌 70 ( 1 ) 47 - 47 2020.1

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A Comparison of Oral Health in Japan and Germany and Its Cost Efficiency(和訳中) Reviewed

Kocher Thomas, Iwasaki Masanori, Yoshihara Akihiro, Hoshino Takashi

老年歯科医学 34 ( 3 ) 342 - 353 2019.12

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歯科衛生士が行う専門的な処置に要する時間とその関連要因

高野綾子, 柴田佐都子, 八木稔, 葭原明弘

新潟歯学会雑誌 49 ( 2 ) 81 - 81 2019.12

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日本とドイツにおける口腔健康とその費用効率性に関する比較(A Comparison of Oral Health in Japan and Germany and Its Cost Efficiency)

Kocher Thomas, Iwasaki Masanori, Yoshihara Akihiro, Hoshino Takashi

老年歯科医学 34 ( 3 ) 342 - 353 2019.12

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日本とドイツには共に診療報酬制の法定健康保険制度があり、しかも口腔健康に関する代表的な調査研究が存在している。ドイツの代表的研究であるDeutsche Mundgesundheitsstudie(DMS III、DMS IV、DMS V研究)と日本の厚生労働省による歯科疾患実態調査のデータを利用し、両国の一般集団にみられる口腔健康と歯科健康保険制度のパフォーマンスを比較した。1997年におけるドイツ人の成人集団(35〜44歳)の平均歯数は25.3本、2014年では27.2本であった。日本の1999年の成人集団では27.2本、2016年では28.3本であった。高齢集団(65〜74歳)に関しては、上記と同じ2時点においてドイツ人の場合には平均歯数は10.1本と15.5本、日本人の場合には14.7本と22.7本であり、両国において歯数は増加していた。上記のように両国間の比較では成人集団、高齢集団のいずれの場合でも日本人の残存歯数の方が多かった。ドイツ人1人当たりの歯科診療医療費は上記と同じ2時点において216ユーロと302ユーロ、日本人では178ユーロと195ユーロであった。残存歯数の観点から総合的に判断するとドイツよりも日本の方が歯科医療費資源を効率的に利用していると考えられた。

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地域在住高齢者における唾液量と血中コレステロールの関連

溝口奈菜, 濃野要, 金子昇, 伊藤加代子, 船山さおり, 葭原明弘, 小川祐司

新潟歯学会雑誌 49 ( 2 ) 80 - 80 2019.12

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高齢者の「肉の脂身を好んで食べる」食習慣と血液状況、身体状況、食品群別摂取量との関連

小田島祐美子, 葭原明弘, 渡邊智子, 小川祐司

新潟歯学会雑誌 49 ( 2 ) 73 - 74 2019.12

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血清抗Porphyromonas gingivalis IgG抗体価と肝機能マーカー値の関連性新潟県佐渡市における横断研究

高見澤圭, 杉田典子, 葭原明弘, 小林哲夫, 吉江弘正, 多部田康一

日本歯周病学会会誌 61 ( 秋季特別 ) 130 - 130 2019.10

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地域在住高齢者における高次生活機能の加齢変化パターンと歯の本数の関連 10年間の前向きコホート研究

岩崎正則, 佐藤美寿々, 葭原明弘

老年歯科医学 34 ( 2 ) 261 - 261 2019.9

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Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4-year cohort study. Reviewed International journal

Iwasaki M, Taylor GW, Sato M, Minagawa K, Ansai T, Yoshihara A

Journal of periodontology 90 ( 8 ) 826 - 833 2019.8

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BACKGROUND: People with chronic kidney disease (CKD) may have an increased risk of periodontal disease, but longitudinal evidence is sparse. METHODS: This 4-year cohort study assessed the association between CKD and changes in periodontal health status, defined by attachment loss (AL) progression, among older adults. Participants were 388 community-dwelling Japanese adults who were 70 years old at baseline with 7053 teeth. Estimated glomerular filtration rate (eGFR) was calculated by using baseline serum creatinine concentration. AL at six sites for every tooth was recorded at baseline and follow-up examinations. Multilevel logistic regression models estimated the tooth-specific risk of AL progression (≥1 site exhibiting a ≥3 mm increase in AL) with baseline CKD (eGFR < 60 mL/min/1.73 m2 ) as the principal exposure. RESULTS: At baseline, 27.8% of the study population (108/388 participants) had CKD. After 4 years, 21.8% of the studied teeth (1537/7053 teeth) exhibited AL progression. After applying inverse probability weighting and adjusting for potential confounders, including sex, use of devices for interdental cleaning, smoking, diabetes, tooth location, abutment for a removable denture, and highest AL, CKD was associated with significantly higher odds of AL progression (adjusted odds ratio: 1.73; 95% confidence interval: 1.15-2.60). CONCLUSIONS: The results suggest that CKD increases the risk of periodontal disease progression in older community-dwelling Japanese adults. Additional studies with more complete information, as well as in other geographic areas and age groups, are necessary to further generalize the findings.

DOI： 10.1002/JPER.18-0464

PubMed

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歯科衛生士が行う専門的な処置に要する時間の実態調査とその時間に関連する要因

高野綾子, 柴田佐都子, 古川泉, 牧田由依, 小林実可子, 小島千奈美, 駒澤美幸, 本多麻有子, 本間しのぶ, 葭原明弘

日本歯科衛生学会雑誌 14 ( 1 ) 110 - 110 2019.8

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Predicting gingivitis using visual gingival redness examination on 11 years old Japanese schoolchildren: A ROC analysis Reviewed

Lisdrianto Hanindriyo, Akihiro Yoshihara, Hiro-O Ito, Kana Suwama, Satoko Kakuta, Makoto Fukui, Masanori Iwasaki, Naofumi Tamaki, Toshihiro Ansai

PEDIATRIC DENTAL JOURNAL 29 ( 2 ) 66 - 71 2019.8

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DOI： 10.1016/j.pdj.2019.05.001

Web of Science

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加齢に伴う歯数の変化の軌跡と生命予後の関連高齢期に28歯を維持することの意義

岩崎正則, 佐藤美寿々, 皆川久美子, 安細敏弘, 小川祐司, 葭原明弘

口腔衛生学会雑誌 69 ( 3 ) 131 - 138 2019.7

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A polymorphism rs6815464 in the macrophage erythroblast attacher gene is associated with low bone mineral density in postmenopausal Japanese women. Reviewed International journal

Yulan Che, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie

Gene 700 1 - 6 2019.6

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BACKGROUND AND PURPOSES: Osteoporosis and osteopenia are multifactorial diseases characterized by low bone mineral density (BMD) and are susceptible to genetic and environmental risk factors. The macrophage erythroblast attacher (MAEA) was discovered as a protein to mediate the attachment of erythroid cells to macrophages and is essential for bone marrow hematopoiesis. MAEA is expressed in a wide range of cells and tissues including osteoblasts and osteoclasts. Recent studies have shown that a single nucleotide polymorphism (SNP) rs6815464 (C/G) in the MAEA gene increases the susceptibility of type 2 diabetes mellitus. However, the contribution of MAEA to bone metabolism remains unknown. Therefore, we performed this study to evaluate the association between MAEA polymorphism and low BMD. METHODS: In a cross-sectional study with postmenopausal Japanese women living in the Yokogoshi area, Niigata City, we evaluated whether rs6815464 was associated with low BMD. Blood samples were collected from 353 subjects (age 63.8 ± 5.4 years). The MAEA genotype was determined by TaqMan assay. BMD was assessed by dual-energy X-ray absorptiometry at the lumbar spine (L2-L4), hip and femoral neck. Low BMD was defined as a T-score <-1. RESULTS: The percentage of subjects with low BMD in the lumbar spine, total hip and femoral neck were 71%, 75% and 84% respectively. After adjusting age, BMI, HbA1c, smoking and alcohol consumption, the G-allele carriage was found to be associated with low BMD of total hip (odds ratio = 2.11, 95% CI: 1.14-3.91, P = 0.018), but not of the lumbar spine or femoral neck. CONCLUSION: The MAEA gene polymorphism rs6815464 was associated with low hip BMD in postmenopausal Japanese women.

DOI： 10.1016/j.gene.2019.03.027

PubMed

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MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females: A cross-sectional study. Reviewed International journal

Yulan Che, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie

Archives of oral biology 102 128 - 134 2019.6

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OBJECTIVES: Macrophage erythroblast attacher (MAEA) is a membrane protein that regulates the development of mature macrophages by mediating attachment with erythroblasts. A polymorphism rs6815464 (C/G) in MAEA gene was reported to be associated with type II diabetes. Along with diabetes, osteoporosis shows an increased prevalence in postmenopausal females, and both diseases have been reported to be associated with periodontitis. Therefore, we explored the relevance of the MAEA polymorphism to periodontitis, bone mineral density (BMD) and haemoglobin A1c (HbA1c). DESIGN: This was a cross-sectional study with the final sample comprised of 344 postmenopausal Japanese females. Probing pocket depth (PPD) and clinical attachment level (CAL) were measured. Genotype was determined by TaqMan assay. Blood biochemical parameters and BMD of the lumbar spine were evaluated. RESULTS: No differences were found in age, body mass index, HbA1c, BMD, number of teeth, bone metabolism parameters between the genotypes. Mean CAL and percentage of sites with PPD or CAL ≥ 5 mm were higher in the G-allele carriers than in the non-carriers. Multiple logistic regression analyses revealed that G-allele carriage was associated with severe periodontitis (odds ratio = 3.73, 95% CI = 1.36-10.19). CONCLUSION: Our results suggested that the MAEA gene polymorphism was independently associated with severe periodontitis.

DOI： 10.1016/j.archoralbio.2019.04.008

PubMed

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Interaction between beta-3 adrenergic receptor genotype and environmental factors on periodontal progression. Reviewed International journal

Akihiro Yoshihara, Noboru Kaneko, Kaname Nohno, Masanori Iwasaki

Journal of clinical periodontology 46 ( 6 ) 623 - 630 2019.6

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OBJECTIVES: The purpose of this longitudinal study was to evaluate the relationship between beta-3 adrenergic receptor polymorphism and environmental factors such as smoking on periodontal disease by considering effect modification. MATERIALS AND METHODS: A total of 294 subjects who participated in all follow-up surveys over the 6-year study period were analysed. After dividing subjects into tertiles according to the number of years exposed to smoking, we conducted Poisson regression analysis to compare the incidence rate ratio (IRR) for periodontal disease events during the 6-year study period with beta-3 adrenergic receptor genotype (1: Arg allele carriers, 2: Arg allele non-carriers) for each tertile adjusted for other four variables. RESULTS: The number of years exposed to smoking (mean ± standard deviation) for the 1st, 2nd and 3rd tertiles was 0 ± 0, 20.1 ± 9.1 and 45.3 ± 7.7 years, respectively. The IRRs ± SE were 0.89 ± 0.08 (p = 0.218) for the 1st tertile, 1.93 ± 0.36 (p < 0.001) for the 2nd tertile and 2.56 ± 0.23 (p < 0.001) for the 3rd tertile. CONCLUSION: There was a clear dose-response relationship between beta-3 adrenergic receptor genotype and periodontal disease progression based on the number of years exposed to smoking.

DOI： 10.1111/jcpe.13115

PubMed

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地域在住高齢者における高次生活機能の加齢変化パターンと歯の本数の関連 10年間の前向きコホート研究

岩崎正則, 佐藤美寿々, 葭原明弘

日本老年歯科医学会総会・学術大会プログラム・抄録集 30回 P一般 - 089 2019.6

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Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Honor Bixby, James Bentham, Bin Zhou, Mariachiara Di Cesare, Christopher J. Paciorek, James E. Bennett, Cristina Taddei, Gretchen A. Stevens, Andrea Rodriguez-Martinez, Rodrigo M. Carrillo-Larco, Young-Ho Khang, Maroje Sorić, Edward W. Gregg, J. Jaime Miranda, Zulfiqar A. Bhutta, Stefan Savin, Marisa K. Sophiea, Maria L. C. Iurilli, Bethlehem D. Solomon, Melanie J. Cowan, Leanne M. Riley, Goodarz Danaei, Pascal Bovet, Adela Chirita-Emandi, Ian R. Hambleton, Alison J. Hayes, Nayu Ikeda, Andre P. Kengne, Avula Laxmaiah, Yanping Li, Stephen T. McGarvey, Aya Mostafa, Martin Neovius, Gregor Starc, Ahmad A. Zainuddin, Leandra Abarca-Gómez, Ziad A. Abdeen, Shynar Abdrakhmanova, Suhaila Abdul Ghaffar, Zargar Abdul Hamid, Jamila Abubakar Garba, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J. Adams, Wichai Aekplakorn, Kaosar Afsana, Imelda A. Agdeppa, Carlos A. 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Nature 569 ( 7755 ) 260 - 264 2019.5

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Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Publishing Group

DOI： 10.1038/s41586-019-1171-x

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Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: Perioperative oral health care can prevent postoperative complications, but it is also important to maintain oral health afterward to avoid later adverse events. This study examined (a) the relationship between knowledge and attitude toward oral health (KAOH) and oral/periodontal status (OPS) in patients receiving surgery, and (b) the changes in KAOH by perioperative oral health care and education. METHODS: Patients receiving surgery who visited our hospital's dental clinic beforehand were prospectively recruited. All participants received oral health care and education. In questionnaires assessing KAOH before and after surgery, respondent answers were generally classified as positive or negative. OPS was assessed before surgery. Associations between KAOH and OPS and perioperative changes in KAOH were statistically tested. RESULTS: A total of 507 patients answered the questionnaire before surgery, among whom 324 patients also completed it afterward. Preoperative OPS was significantly worse in the negative than in the positive KAOH group. Positive answers for KAOH increased significantly from 68.6% to 92.2% during the perioperative period. CONCLUSIONS: We found that patients with poor KAOH also had poor OPS, but KAOH could be improved by perioperative oral health care and education, suggesting that perioperative oral health management could improve oral health knowledge and attitudes.

DOI： 10.1111/odi.13048

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地域在宅超高齢者の食事パターンと栄養状態、栄養素摂取量および嚥下との関連

濱嵜朋子, 岩崎正則, 角田聡子, 片岡正太, 濃野要, 葭原明弘, 小川祐司, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 69 ( 増刊 ) 161 - 161 2019.4

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職域における歯科健診と個別保健指導による行動変容 Reviewed

金子昇, 葭原明弘, 濃野要, 山賀孝之, 財津崇, 川口陽子, 宮崎秀夫

口腔衛生会誌 J Dent Hlth69 69 ( 1 ) 27 - 33 2019.1

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小児の歯肉炎評価におけるGCFの応用に関する検討 Reviewed

角田聡子, 邵仁浩, 葭原明弘, 福井誠, 岩崎正則, 諏訪間加奈, 鶴田実穂, 平山綾, 片岡正太, 茂山博代, 横田誠, 牛島直文, 玉木直文, 伊藤博夫, 安細敏弘

口腔衛生学会雑誌 69 ( 1 ) 19 - 26 2019.1

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歯科医師および歯科衛生士数と歯科診療所で担うことのできる診療内容との関連(平成24年新潟県歯科医療機能連携実態調査より)

皆川久美子, 葭原明弘, 佐藤美寿々, 荒井節男, 清田義和, 宮崎秀夫

口腔衛生学会雑誌 69 ( 1 ) 10 - 18 2019.1

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主観的評価による現在歯数調査の妥当性について

星野剛志, 皆川久美子, 葭原明弘, 深井穫博, 安藤雄一, 嶋崎義浩, 神原正樹, 宮崎秀夫

口腔衛生学会雑誌 69 ( 1 ) 50 - 51 2019.1

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歯科受診者における受診理由と主観的全身健康観の関連

市川優, 皆川久美子, 葭原明弘, 深井穫博, 安藤雄一, 嶋崎義浩, 神原正樹, 宮崎秀夫

口腔衛生学会雑誌 69 ( 1 ) 51 - 51 2019.1

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地域在住高齢者における唾液量と血中コレステロールの関連

溝口奈菜, 濃野要, 金子昇, 小川祐司, 葭原明弘

口腔衛生学会雑誌 69 ( 1 ) 50 - 50 2019.1

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Association between the Numbers of Dentists/Dental Hygienists Working in Dental Clinics and Their Service Contents -From the Survey on the Cooperation of Dentistry Medical Function in Niigata-

MINAGAWA Kumiko, YOSHIHARA Akihiro, SATO Misuzu, ARAI Setsuo, SEIDA Yoshikazu, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 69 ( 1 ) 10 - 18 2019

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 With advanced aging, there are growing demands for the management of sick persons and medical liaison systems. In such a situation, clinics are expected to play roles as primary medical institutions, such as dealing with diverse patients and promoting community-based multi-professional collaboration. To clarify the association between the statuses of different types of professionals working in dental clinics and their service contents, a questionnaire survey was conducted, involving all dental clinics in Niigata Prefecture (1,186 as of August 1, 2012), along with examination of their service provision in July of the same year. Among these clinics, 950 that responded to the questionnaire without missing values were analyzed. With the number of dentists or dental hygienists working in the study clinics as an explanatory variable and those of dental assistants and clerks as covariances, logistic regression analysis was performed to analyze the contents of home dental care services. Ordered logistic regression analysis was also used to examine the management of patients with disabilities and the provision of feeding/swallowing guidance. The items only associated with the number of dental hygienists were home dental care services, visits to care facilities, dental hygiene guidance for care facilities, and the management of patients with disabilities (adjusted odds ratio [95% confidence interval]=1.12 [1.03-1.23], 1.11 [1.03-1.23], 1.31 [1.16-1.47], and 1.27 [1.16-1.40], respectively). The provision of feeding/swallowing guidance was only associated with the number of dentists (1.24 [1.04-1.48]). In order to promote the management of diverse patients in dental clinics and their liaison with hospitals, it may be necessary to enhance dentists' awareness as a premise and basis for ensuring sufficient numbers of dentists and dental hygienists working in such clinics.

DOI： 10.5834/jdh.69.1_10

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Self-Feeding Ability as a Predictor of Mortality Japanese Nursing Home Residents: A Two-Year Longitudinal Study. Reviewed

Sakamoto M, Watanabe Y, Edahiro A, Motokawa K, Shirobe M, Hirano H, Ito K, Kanehisa Y, Yamada R, Yoshihara A

The journal of nutrition, health & aging 23 ( 2 ) 157 - 164 2019

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DOI： 10.1007/s12603-018-1125-2

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The number of remaining teeth as a risk indicator of cognitive impairment: A cross-sectional clinical study in Sado Island. Reviewed International journal

Ayumi Kuroki, Noriko Sugita, Shigeki Komatsu, Minako Wakasugi, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie

Clinical and experimental dental research 4 ( 6 ) 291 - 296 2018.12

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Most studies that have demonstrated an association between number of remaining teeth and cognitive impairment have treated teeth as a continuous variable, although the relationship is nonlinear. The aim of this cross-sectional study was to determine the critical number of remaining teeth in hospital outpatients at which the association with cognitive impairment becomes apparent. Japanese adults living on Sado Island who visited Sado General Hospital were invited to participate in Project in Sado for Total Health. In total, 2,530 adults were interviewed and had their teeth counted; 1,476 of these individuals also completed the Mini-Mental State Examination (MMSE) and underwent measurement of their serum high-sensitivity C-reactive protein (hsCRP) levels. Patients on dialysis and those with hsCRP ≥ 10 mg/L were excluded. The final study group consisted of 565 adults (290 men and 275 women) of mean age 69.8 (range 29-91) years. An MMSE score < 24 was considered to indicate cognitive impairment. The subjects were categorized according to whether they had an edentulous jaw or one to 10, 11-20, 21-27, or ≥28 remaining teeth. One hundred twenty-eight of the 565 study participants were diagnosed to have cognitive impairment. Multiple logistic regression analysis revealed associations of cognitive impairment with older age, ischemic heart disease, smoking, and alcohol consumption. After adjustment for covariates, having one to 10 remaining teeth was significantly associated with cognitive impairment. There is a significant association between having only one to 10 remaining teeth and cognitive impairment in hospital outpatients.

DOI： 10.1002/cre2.147

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地域在住高齢者における臼歯部の咬合支持の変化と低栄養(PEM)の関連に関する縦断的研究

野々村絢子, 濃野要, 葭原明弘, 小川祐司

新潟歯学会雑誌 48 ( 2 ) 125 - 125 2018.12

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一般地域住民における主観的な歯や歯肉の健康状態と全身健康状態との関連 8020推進財団「一般地域住民を対象とした歯・口腔の健康に関する調査研究」より

皆川久美子, 葭原明弘, 佐藤美寿々, 深井穫博, 安藤雄一, 嶋崎義浩, 古田美智子, 相田潤, 神原正樹, 宮崎秀夫

口腔衛生学会雑誌 68 ( 4 ) 198 - 206 2018.10

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Hyposalivation and 10-year all-cause mortality in an elderly Japanese population

Masanori Iwasaki, Wenche S. Borgnakke, Akihiro Yoshihara, Kayoko Ito, Hiroshi Ogawa, Kaname Nohno, Misuzu Sato, Kumiko Minagawa, Toshihiro Ansai, Hideo Miyazaki

Gerodontology 35 ( 2 ) 87 - 94 2018.6

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Language：English Publishing type：Research paper (scientific journal) Publisher：Blackwell Munksgaard

DOI： 10.1111/ger.12319

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Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants

Bin Zhou, James Bentham, Mariachiara Di Cesare, Honor Bixby, Goodarz Danaei, Kaveh Hajifathalian, Cristina Taddei, Rodrigo M Carrillo-Larco, Shirin Djalalinia, Shahab Khatibzadeh, Charles Lugero, Niloofar Peykari, Wan Zhu Zhang, James Bennett, Ver Bilano, Gretchen A Stevens, Melanie J Cowan, Leanne M Riley, Zhengming Chen, Ian R Hambleton, Rod T Jackson, Andre Pascal Kengne, Young-Ho Khang, Avula Laxmaiah, Jing Liu, Reza Malekzadeh, Hannelore K Neuhauser, Maroje Sorić, Gregor Starc, Johan Sundström, Mark Woodward, Majid Ezzati, Leandra Abarca-Gómez, Ziad A Abdeen, Niveen M Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Carlos A Aguilar-Salinas, Charles Agyemang, Noor Ani Ahmad, Alireza Ahmadvand, Wolfgang Ahrens, Kamel Ajlouni, Nazgul Akhtaeva, Rajaa Al-Raddadi, Mohamed M Ali, Osman Ali, Ala'a Alkerwi, Eman Aly, Deepak N Amarapurkar, Philippe Amouyel, Antoinette Amuzu, Lars Bo Andersen, Sigmund A Anderssen, Lars H Ängquist, Ranjit Mohan Anjana, Daniel Ansong, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Nimmathota Arlappa, Dominique Arveiler, Krishna K Aryal, Thor Aspelund, Felix K Assah, Maria Cecília F Assunção, Mária Avdicová, Ana Azevedo, Fereidoun Azizi, Bontha V Babu, Suhad Bahijri, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R Banegas, Carlo M Barbagallo, Alberto Barceló, Amina Barkat, Aluisio J D Barros, Mauro V Barros, Iqbal Bata, Anwar M Batieha, Assembekov Batyrbek, Louise A Baur, Robert Beaglehole, Habiba Ben Romdhane, Mikhail Benet, Lowell S Benson, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloisa Bettiol, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K Bhargava, Yufang Bi, Mukharram Bikbov, Bihungum Bista, Peter Bjerregaard, Espen Bjertness, Marius B Bjertness, Cecilia Björkelund, Anneke Blokstra, Simona Bo, Martin Bobak, Heiner Boeing, Jose G Boggia, Carlos P Boissonnet, Vanina Bongard, Rossana Borchini, Pascal Bovet, Lutgart Braeckman, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, Hermann Brenner, Lizzy M Brewster, Graziella Bruno, H B(as) Bueno-de-Mesquita, Anna Bugge, Con Burns, Michael Bursztyn, Antonio Cabrera de León, Joseph Cacciottolo, Hui Cai, Christine Cameron, Günay Can, Ana Paula C Cândido, Vincenzo Capuano, Viviane C Cardoso, Axel C Carlsson, Maria J Carvalho, Felipe F Casanueva, Juan-Pablo Casas, Carmelo A Caserta, Snehalatha Chamukuttan, Angelique W Chan, Queenie Chan, Himanshu K Chaturvedi, Nishi Chaturvedi, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Imane Cherkaoui Dekkaki, Angela Chetrit, Arnaud Chiolero, Shu-Ti Chiou, Adela Chirita-Emandi, María-Dolores Chirlaque, Belong Cho, Yumi Cho, Diego G Christofaro, Jerzy Chudek, Renata Cifkova, Eliza Cinteza, Frank Claessens, Els Clays, Hans Concin, Cyrus Cooper, Rachel Cooper, Tara C Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L Craig, Ana B Crujeiras, Juan J Cruz, Graziella D'Arrigo, Eleonora d'Orsi, Jean Dallongeville, Albertino Damasceno, Goodarz Danaei, Rachel Dankner, Thomas M Dantoft, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, Delphine De Smedt, Mohan Deepa, Abbas Dehghan, Hélène Delisle, Valérie Deschamps, Klodian Dhana, Augusto F Di Castelnuovo, Juvenal Soares Dias-da-Costa, Alejandro Diaz, Ty T Dickerson, Shirin Djalalinia, Ha T P Do, Chiara Donfrancesco, Silvana P Donoso, Angela Döring, Maria Dorobantu, Kouamelan Doua, Wojciech Drygas, Virginija Dulskiene, Aleksandar Džakula, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Robert Eggertsen, Ulf Ekelund, Jalila El Ati, Paul Elliott, Roberto Elosua, Rajiv T Erasmus, Cihangir Erem, Louise Eriksen, Johan G Eriksson, Jorge Escobedo-de la Peña, Alun Evans, David Faeh, Caroline H Fall, Farshad Farzadfar, Francisco J Felix-Redondo, Trevor S Ferguson, Romulo A Fernandes, Daniel Fernández-Bergés, Daniel Ferrante, Marika Ferrari, Catterina Ferreccio, Jean Ferrieres, Joseph D Finn, Krista Fischer, Bernhard Föger, Leng Huat Foo, Ann-Sofie Forslund, Maria Forsner, Heba M Fouad, Damian K Francis, Maria do Carmo Franco, Oscar H Franco, Guillermo Frontera, Flavio D Fuchs, Sandra C Fuchs, Yuki Fujita, Takuro Furusawa, Zbigniew Gaciong, Fabio Galvano, Manoli Garcia-de-la-Hera, Dickman Gareta, Sarah P Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Johanna M Geleijnse, Anoosheh Ghasemian, Anup Ghimire, Simona Giampaoli, Francesco Gianfagna, Tiffany K Gill, Jonathan Giovannelli, Rebecca A Goldsmith, Helen Gonçalves, Marcela Gonzalez-Gross, Juan P González-Rivas, Mariano Bonet Gorbea, Frederic Gottrand, Sidsel Graff-Iversen, Dušan Grafnetter, Aneta Grajda, Maria G Grammatikopoulou, Ronald D Gregor, Tomasz Grodzicki, Anders Grøntved, Giuseppe Grosso, Gabriella Gruden, Vera Grujic, Dongfeng Gu, Ong Peng Guan, Elias F Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L Guimaraes, Martin C Gulliford, Johanna Gunnlaugsdottir, Marc Gunter, Prakash C Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Farzad Hadaegh, Jytte Halkjær, Ian R Hambleton, Rebecca Hardy, Rachakulla Hari Kumar, Jun Hata, Alison J Hayes, Jiang He, Yuna He, Marleen Elisabeth, Ana Henriques, Leticia Hernandez Cadena, Sauli Herrala, Ramin Heshmat, Ilpo Tapani Hihtaniemi, Sai Yin Ho, Suzanne C Ho, Michael Hobbs, Albert Hofman, Gonul Horasan Dinc, Andrea R V R Horimoto, Claudia M Hormiga, Bernardo L Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Martijn Huisman, Abdullatif S Husseini, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G Iannone, Mohsen M Ibrahim, Norazizah Ibrahim Wong, Nayu Ikeda, M Arfan Ikram, Vilma E Irazola, Muhammad Islam, Aziz al-Safi Ismail, Vanja Ivkovic, Masanori Iwasaki, Rod T Jackson, Jeremy M Jacobs, Hashem Jaddou, Tazeen Jafar, Konrad Jamrozik, Imre Janszky, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Seung-lyeal Jeong, Chao Qiang Jiang, Michel Joffres, Mattias Johansson, Jari J Jokelainen, Jost B Jonas, Torben Jørgensen, Pradeep Joshi, Jacek Jóźwiak, Anne Juolevi, Gregor Jurak, Vesna Jureša, Rudolf Kaaks, Anthony Kafatos, Eero O Kajantie, Ofra Kalter-Leibovici, Nor Azmi Kamaruddin, Khem B Karki, Amir Kasaeian, Joanne Katz, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Han C G Kemper, Andre P Kengne, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Young-Ho Khang, Mohammad Khateeb, Kay-Tee Khaw, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Japhet Killewo, Jeongseon Kim, Yeon-Yong Kim, Jurate Klumbiene, Michael Knoflach, Elin Kolle, Patrick Kolsteren, Paul Korrovits, Seppo Koskinen, Katsuyasu Kouda, Sudhir Kowlessur, Slawomir Koziel, Susi Kriemler, Peter Lund Kristensen, Steinar Krokstad, Daan Kromhout, Herculina S Kruger, Ruzena Kubinova, Renata Kuciene, Diana Kuh, Urho M Kujala, Zbigniew Kulaga, R Krishna Kumar, Pawel Kurjata, Yadlapalli S Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Tiina Laatikainen, Carl Lachat, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Bagher Larijani, Lars E Laugsand, Avula Laxmaiah, Khanh Le Nguyen Bao, Tuyen D Le, Catherine Leclercq, Jeannette Lee, Jeonghee Lee, Terho Lehtimäki, Luz M León-Muñoz, Naomi S Levitt, Yanping Li, Christa L Lilly, Wei-Yen Lim, M Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Lars Lind, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Jing Liu, Roberto Lorbeer, Paulo A Lotufo, José Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Per Lytsy, Guansheng Ma, Jun Ma, George L L Machado-Coelho, Suka Machi, Stefania Maggi, Dianna J Magliano, Emmanuella Magriplis, Marjeta Majer, Marcia Makdisse, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Yannis Manios, Jim I Mann, Enzo Manzato, Paula Margozzini, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Reynaldo Martorell, Ellisiv B Mathiesen, Alicia Matijasevich, Tandi E Matsha, Jean Claude N Mbanya, Anselmo J Mc Donald Posso, Shelly R McFarlane, Stephen T McGarvey, Stela McLachlan, Rachael M McLean, Scott B McLean, Breige A McNulty, Sounnia Mediene-Benchekor, Jurate Medzioniene, Aline Meirhaeghe, Christa Meisinger, Ana Maria B Menezes, Geetha R Menon, Indrapal I Meshram, Andres Metspalu, Haakon E Meyer, Jie Mi, Kairit Mikkel, Jody C Miller, Cláudia S Minderico, Juan Francisco, J Jaime Miranda, Erkin Mirrakhimov, Marjeta Mišigoj-Durakovic, Pietro A Modesti, Mostafa K Mohamed, Kazem Mohammad, Noushin Mohammadifard, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Line T Møllehave, Niels C Møller, Dénes Molnár, Amirabbas Momenan, Charles K Mondo, Kotsedi Daniel K Monyeki, Jin Soo Moon, Leila B Moreira, Alain Morejon, Luis A Moreno, Karen Morgan, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Kelias P Msyamboza, Thet Thet Mu, Maria L Muiesan, Martina Müller-Nurasyid, Neil Murphy, Jaakko Mursu, Vera Musil, Iraj Nabipour, Gabriele Nagel, Balkish M Naidu, Harunobu Nakamura, Jana Námešná, Ei Ei K Nang, Vinay B Nangia, Sameer Narake, Matthias Nauck, Eva Maria Navarrete-Muñoz, Ndeye Coumba Ndiaye, William A Neal, Ilona Nenko, Martin Neovius, Flavio Nervi, Hannelore K Neuhauser, Chung T Nguyen, Nguyen D Nguyen, Quang Ngoc Nguyen, Quang V Nguyen, Ramfis E Nieto-Martínez, Teemu J Niiranen, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Oscar A Noboa, Ahmad Ali Noorbala, Teresa Norat, Davide Noto, Mohannad Al Nsour, Dermot O'Reilly, Eiji Oda, Glenn Oehlers, Kyungwon Oh, Kumiko Ohara, Maria Teresa A Olinto, Isabel O Oliveira, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Lariane M Ono, Pedro Ordunez, Rui Ornelas, Clive Osmond, Sergej M Ostojic, Afshin Ostovar, Johanna A Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Elena Pahomova, Andrzej Pajak, Domenico Palli, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Dimitrios Papandreou, Soon-Woo Park, Winsome R Parnell, Mahboubeh Parsaeian, Nikhil D Patel, Ivan Pecin, Mangesh S Pednekar, Nasheeta Peer, Petra H Peeters, Sergio Viana Peixoto, Markku Peltonen, Alexandre C Pereira, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Niloofar Peykari, Son Thai Pham, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Freda Pitakaka, Aleksandra Piwonska, Pedro Plans-Rubió, Ozren Polašek, Miquel Porta, Marileen L P Portegies, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Mathur Prashant, Jacqueline F Price, Jardena J Puder, Maria Puiu, Margus Punab, Radwan F Qasrawi, Mostafa Qorbani, Tran Quoc Bao, Ivana Radic, Ricardas Radisauskas, Mahfuzar Rahman, Olli Raitakari, Manu Raj, Sudha Ramachandra Rao, Ambady Ramachandran, Elisabete Ramos, Lekhraj Rampal, Sanjay Rampal, Daniel A Rangel Reina, Josep Redon, Paul Ferdinand M Reganit, Robespierre Ribeiro, Elio Riboli, Fernando Rigo, Tobias F Rinke de Wit, Raphael M Ritti-Dias, Sian M Robinson, Cynthia Robitaille, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A Rodríguez-Villamizar, Rosalba Rojas-Martinez, Dora Romaguera, Kimmo Ronkainen, Annika Rosengren, Joel G R Roy, Adolfo Rubinstein, Blanca Sandra Ruiz-Betancourt, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S Sachdev, Olfa Saidi, Sibel Sakarya, Benoit Salanave, Eduardo Salazar Martinez, Diego Salmerón, Veikko Salomaa, Jukka T Salonen, Massimo Salvetti, Jose Sánchez-Abanto, Susana Sans, Diana A Santos, Ina S Santos, Renata Nunes dos Santos, Rute Santos, Jouko L Saramies, Luis B Sardinha, Giselle Sarganas, Nizal Sarrafzadegan, Kai-Uwe Saum, Savvas Savva, Marcia Scazufca, Herman Schargrodsky, Sabine Schipf, Carsten O Schmidt, Ben Schöttker, Constance Schultsz, Aletta E Schutte, Aye Aye Sein, Abhijit Sen, Idowu O Senbanjo, Sadaf G Sepanlou, Sanjib K Sharma, Jonathan E Shaw, Kenji Shibuya, Dong Wook Shin, Youchan Shin, Khairil Si-Ramlee, Rosalynn Siantar, Abla M Sibai, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A Simons, Michael Sjöström, Sine Skovbjerg, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Margaret C Smith, Marieke B Snijder, Hung-Kwan So, Eugène Sobngwi, Stefan Söderberg, Vincenzo Solfrizzi, Emily Sonestedt, Yi Song, Thorkild I A Sørensen, Maroje Soric, Charles Sossa Jérome, Aicha Soumare, Jan A Staessen, Gregor Starc, Maria G Stathopoulou, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D Stein, George S Stergiou, Jochanan Stessman, Jutta Stieber, Doris Stöckl, Tanja Stocks, Jakub Stokwiszewski, Karien Stronks, Maria Wany Strufaldi, Chien-An Sun, Johan Sundström, Yn-Tz Sung, Paibul Suriyawongpaisal, Rody G Sy, E Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Carolina B Tarqui-Mamani, Oana-Florentina Tautu, Anne Taylor, Holger Theobald, Xenophon Theodoridis, Lutgarde Thijs, Betina H Thuesen, Anne Tjonneland, Hanna K Tolonen, Janne S Tolstrup, Murat Topbas, Roman Topór-Madry, María José Tormo, Maties Torrent, Pierre Traissac, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh T H Trinh, Atul Trivedi, Lechaba Tshepo, Marshall K Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L Turley, Per Tynelius, Christophe Tzourio, Peter Ueda, Eunice E Ugel, Hanno Ulmer, Hannu M T Uusitalo, Gonzalo Valdivia, Damaskini Valvi, Yvonne T van der Schouw, Koen Van Herck, Hoang Van Minh, Lenie van Rossem, Natasja M Van Schoor, Irene G M van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Lars Vatten, Tomas Vega, Gustavo Velasquez-Melendez, Giovanni Veronesi, W M Monique Verschuren, Roosmarijn Verstraeten, Cesar G Victora, Lucie Viet, Eira Viikari-Juntura, Paolo Vineis, Jesus Vioque, Jyrki K Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Tiina Vlasoff, Peter Vollenweider, Sari Voutilainen, Alisha N Wade, Aline Wagner, Janette Walton, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo S Wanderley, Ming-Dong Wang, Qian Wang, Ya Xing Wang, Ying-Wei Wang, S Goya Wannamethee, Nicholas Wareham, Niels Wedderkopp, Deepa Weerasekera, Peter H Whincup, Kurt Widhalm, Indah S Widyahening, Andrzej Wiecek, Alet H Wijga, Rainford J Wilks, Johann Willeit, Peter Willeit, Emmanuel A Williams, Tom Wilsgaard, Bogdan Wojtyniak, Roy A Wong-McClure, Justin Y Y Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Aleksander Giwercman Wu, Frederick C Wu, Shouling Wu, Haiquan Xu, Weili Yan, Xiaoguang Yang, Xingwang Ye, Panayiotis K Yiallouros, Akihiro Yoshihara, Novie O Younger-Coleman, Ahmad Faudzi Yusoff, Ahmad Ali Zainuddin, Sabina Zambon, Antonis Zampelas, Tomasz Zdrojewski, Yi Zeng, Dong Zhao, Wenhua Zhao, Wei Zheng, Yingfeng Zheng, Dan Zhu, Baurzhan Zhussupov, Esther Zimmermann, Julio Zuñiga Cisneros

International Journal of Epidemiology 47 ( 3 ) 872 - 883i 2018.6

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DOI： 10.1093/ije/dyy016

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Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community-dwelling elderly. Reviewed International journal

Akihiro Yoshihara, Noboru Kaneko, Masanori Iwasaki, Kaname Nohno, Hideo Miyazaki

Journal of clinical periodontology 45 ( 6 ) 672 - 679 2018.6

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OBJECTIVES: The aim of this study was to investigate the possible correlation between vitamin D receptor (VDR) gene polymorphism and susceptibility to chronic kidney disease (CKD) and periodontal disease. MATERIAL AND METHODS: This study analysed 345 participants, who were all 79 years of age. Kidney function levels were determined based on the estimated glomerular filtration rate (eGFR; non-reduced function: ≥60 and reduced function: <60 ml min-1 1.73 m-2 ). VDR TaqI genotyping was also studied. We calculated the periodontal inflamed surface area (PISA). After classifying participants into quartile groups according to eGFR or PISA values, the subjects were then split into two groups (highest quartile versus the other three groups combined). Multiple logistic regression analysis was performed to evaluate the odds ratios between the eGFR and VDR TaqI genotype with the different PISA groups. The eGFR was set as the dependent variable while the VDR TaqI genotype, HbA1C, gender, smoking habits and body mass index were defined as independent variables. RESULTS: A significant association was observed between the VDR TaqI genotype and eGFR in the PISA high group (odds ratio = 3.97, p = .027). CONCLUSION: Study results suggest that VDR TaqI genotype might be associated with CKD during inflammatory conditions caused by periodontal disease.

DOI： 10.1111/jcpe.12896

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Relationship between autoantibody associated with rheumatoid arthritis and tooth loss. Reviewed International journal

Yuko Hayashi, George Taylor, Akihiro Yoshihara, Masanori Iwasaki, Stuart A Gansky, Hideo Miyazaki

Gerodontology 2018.5

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INTRODUCTION: This study evaluated the relationship between serum Rheumatoid Factor (RF) levels and tooth loss in a community-dwelling elderly Japanese women. It was hypothesised that women with high baseline RF levels would experience greater tooth loss over 10 years than age-matched women with lower baseline serum RF levels. MATERIALS AND METHODS: The study population consisted of 197 women aged 70 years with ≥12 teeth at baseline. One hundred and twenty-four participants completed a 10-year follow-up and were divided into 2 groups according to their baseline serum RF levels as follows: RF negative (<15 U/mL; n = 114) and RF positive (>15 U/mL; n = 10). Negative binomial regression was used to investigate the relationship between baseline RFs and tooth lost over the 10-year period. RF and its interaction with the baseline number of teeth were independent variables, with 9 other adjustment covariates. RESULTS: Baseline RFs were significantly associated with tooth loss (P = .035). In addition, a statistical interaction between baseline RFs and baseline number of teeth was identified (P = .023), modifying the association between RFs and tooth loss. The adjusted incidence rate ratio (IRR) for RF-positive participants with 21 baseline teeth was 1.88 (95% confidence interval (95% CI): 0.76, 4.65). IRRs obtained for participants who had 25 baseline teeth (3.02; 95% CI: 1.03, 8.83) or 30 baseline teeth (5.47; 95% CI: 1.29, 23.13) suggested that RF-positive participants with a high number of baseline teeth would exhibit greater tooth loss than RF-negative participants. CONCLUSION: High serum RF levels were associated with a greater IRR for future tooth loss in elderly Japanese women.

DOI： 10.1111/ger.12344

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Effect of lifestyle on 6-year periodontitis incidence or progression and tooth loss in older adults. Reviewed International journal

Iwasaki M, Borgnakke WS, Ogawa H, Yamaga T, Sato M, Minagawa K, Ansai T, Yoshihara A, Miyazaki H

Journal of clinical periodontology 45 ( 8 ) 896 - 908 2018.5

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AIM: To evaluate the longitudinal association of combined healthy lifestyle factors with incidence or progression of periodontitis and tooth loss in older adults. MATERIALS AND METHODS: This 6-year study included 374 Japanese 70-year olds with 7,157 teeth, from a source eligible baseline population of 554 individuals. Four lifestyle factors-cigarette smoking, physical activity, relative weight, and dietary quality-were scored as healthy (1 point) or unhealthy (0 point). Adding the individual scores generated the "healthy lifestyle score" (0-4 points). Multilevel mixed-effects logistic regression models were applied to evaluate tooth-specific associations between the baseline healthy lifestyle score and the incidence or progression of periodontitis (increase in clinical attachment loss ≥3 mm) and tooth loss. RESULTS: After 6 years, 19.0% of the teeth exhibited periodontitis incidence or progression and 8.2% were lost. Compared with a healthy lifestyle score of 0-1 (least healthy), the highest score (4 points) was associated with a significantly lower tooth-specific risk of periodontitis (adjusted odds ratio = 0.32; 95% confidence interval: 0.16-0.62) and tooth loss (adjusted odds ratio = 0.42; 95% confidence interval: 0.23-0.77). CONCLUSIONS: Simultaneous adherence to multiple healthy lifestyle factors significantly lowers the risk of incidence or progression of periodontitis and tooth loss in older adults.

DOI： 10.1111/jcpe.12920

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Chronic Intra Oral Pain and Depressive Symptoms in Japanese Community-Dwelling Elderly: A Longitudinal Study. Reviewed

Hanindriyo L, Yoshihara A, Takiguchi T, Miyazaki H

Community dental health 35 ( 2 ) 102 - 108 2018.5

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DOI： 10.1922/CDH_4200Hanindriyo07

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納豆摂取と歯の喪失との関連地域在住閉経後女性を対象とした縦断研究

佐藤美寿々, 岩崎正則, 皆川久美子, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 68 ( 増刊 ) 112 - 112 2018.4

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高次生活機能の加齢に伴う変化の軌跡と歯の本数の関連についての縦断研究

岩崎正則, 佐藤美寿々, 皆川久美子, 安細敏弘, 葭原明弘, 小川祐司, 宮崎秀夫

口腔衛生学会雑誌 68 ( 増刊 ) 112 - 112 2018.4

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在宅超高齢者の栄養状態と栄養素摂取量との関連

濱嵜朋子, 岩崎正則, 角田聡子, 片岡正太, 濃野要, 葭原明弘, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 68 ( 増刊 ) 113 - 113 2018.4

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Relationship between alcohol consumption and periodontal tissue condition in community-dwelling elderly Japanese. Reviewed International journal

Suwama Kana, Yoshihara Akihiro, Watanabe Reiko, Stegaroiu Roxana, Shibata Satoko, Miyazaki Hideo

Gerodontology 2018.3

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OBJECTIVES: To examine the associations among alcohol consumption level, dietary intake and other lifestyle factors, and periodontal condition, in community-dwelling elderly Japanese of a specific age. BACKGROUND: The relationship between alcohol consumption level and periodontitis is a controversial issue. METHODS: Participants were 438 dentate elders aged 73 years from a larger cohort survey of elders in Niigata City, Japan. Data collected from oral examination of each participant, including number of the existing teeth, mean probing pocket depth and mean clinical attachment level (CAL) were used for the analyses. A semiquantitative food frequency questionnaire and a lifestyle habit questionnaire were used to assess food and alcohol consumption, smoking experience, frequency of tooth brushing, interdental brush use, and visits to a dental clinic during the previous year. Blood glucose control was assessed by the glycated haemoglobin (HbA1c) level. Body mass index was calculated from height and weight measurements. The relationships between each variable and the individual mean CAL were analysed by univariate and multivariate analyses. RESULTS: According to logistic regression

DOI： 10.1111/ger.12335

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Relationship between clinical periodontal parameters and changes in liver enzymes levels over an 8-year period in an elderly Japanese population

Elastria Widita, Akihiro Yoshihara, Lisdrianto Hanindriyo, Hideo Miyazaki

Journal of Clinical Periodontology 45 ( 3 ) 311 - 321 2018.3

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Language：English Publishing type：Research paper (scientific journal) Publisher：Blackwell Munksgaard

DOI： 10.1111/jcpe.12861

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Association between serum resistin level and periodontal condition change among elderly people Reviewed

Ogawa H, Damrongrungruang T, Furugen R, Hayashida H, Saito T, Yoshihara A, Miyazaki H

Stoma Edu J 5 ( 1 ) 24 - 30 2018.3

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Dentition status and frailty in community-dwelling older adults: A 5-year prospective cohort study

Masanori Iwasaki, Akihiro Yoshihara, Misuzu Sato, Kumiko Minagawa, Mieko Shimada, Mamoru Nishimuta, Toshihiro Ansai, Yutaka Yoshitake, Hideo Miyazaki

Geriatrics and Gerontology International 18 ( 2 ) 256 - 262 2018.2

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Language：English Publishing type：Research paper (scientific journal) Publisher：Blackwell Publishing

DOI： 10.1111/ggi.13170

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Association of liver enzyme levels and alveolar bone loss: A cross-sectional clinical study in Sado Island. Reviewed International journal

Ayumi Kuroki, Noriko Sugita, Shigeki Komatsu, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie

Journal of clinical and experimental dentistry 10 ( 2 ) e100-e106 - e106 2018.2

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Background: The interaction of periodontopathic bacteria with host immune system induces the production of inflammatory mediators which leads to alveolar bone loss (ABL), the essential feature of periodontitis. Concurrently, periodontal diseases cause the elevation of blood cytokine levels, the alteration of gut microbiota and the dissemination of enterobacteria to the liver. Owing to these mechanisms, periodontal disease might be a risk for liver dysfunction. Several epidemiological studies have reported associations between periodontal diseases and liver dysfunction, although the association between ABL and liver dysfunction has not been investigated. This cross-sectional study determined if elevated serum liver enzyme levels were associated with ABL in Japanese adults. Material and Methods: Japanese adults living on Sado Island who visited Sado General Hospital were invited to participate in the study. Participants over 40 years of age who underwent dental panoramic radiography and blood tests were included. Drinking and smoking habits were self-administered. After excluding patients with edentulous jaw, diagnosed liver diseases, and those on dialysis, data from 44 men and 66 women with a mean age of 73 years were analyzed. The average percentage of ABL for each participant was calculated for mesial and distal sites of all remaining teeth. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were determined. Univariate analyses were performed to select covariates to be put in multivariate analyses. The association between elevated serum liver enzyme levels and the highest quartile of ABL were assessed by multiple logistic regression analysis. Results: After adjusting for covariates, no significant association was found between elevated serum AST, ALT, or GGT levels as dependent variables and the highest quartile of ABL as an explanatory variable. Conclusions: There was no significant association between the elevation of serum liver enzyme levels and ABL in Japanese adults. Key words:Liver enzymes, dental panoramic radiography, alveolar bone loss, Japanese adults.

DOI： 10.4317/jced.54555

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A 5-year longitudinal study of association of maximum bite force with development of frailty in community-dwelling older adults Reviewed

M. Iwasaki, A. Yoshihara, N. Sato, M. Sato, K. Minagawa, M. Shimada, M. Nishimuta, T. Ansai, Y. Yoshitake, T. Ono, H. Miyazaki

JOURNAL OF ORAL REHABILITATION 45 ( 1 ) 17 - 24 2018.1

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DOI： 10.1111/joor.12578

Web of Science

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視診による歯肉炎評価の有用性 Reviewed

渡辺真光, 葭原明弘, 諏訪間加奈, 角田聡子, 岩崎正則, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 68 ( 1 ) 36 - 37 2018.1

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職域における歯科健診単独もしくは歯科健診と保健指導による行動変容

金子昇, 葭原明弘, 野々村絢子, 笹嶋真嵩, 宮本茜, 皆川久美子, 佐藤美寿々, 久保田悠, 濃野要, 山賀孝之, 宮崎秀夫

口腔衛生学会雑誌 68 ( 1 ) 37 - 37 2018.1

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Associations of Tooth Loss, Denture Use, and Self-perceived Denture Fit with Frailty in Community-dwelling Older Adults: A Cross-sectional Study Reviewed

SATO Misuzu, IWASAKI Masanori, MINAGAWA Kumiko, OGAWA Hiroshi, YAMAGA Takayuki, YOSHIHARA Akihiro, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 68 ( 2 ) 68 - 75 2018

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Oral Health

The aim of this cross-sectional study was to evaluate the associations of tooth loss, denture use, and self-perceived denture fit with frailty in community-dwelling older Japanese adults. The subjects were 344 Japanese adults (177 men and 167 women) aged 79 years in Niigata City (Japan), who participated in an oral and general health examination and a questionnaire survey in 2007. Frailty was defined as the presence of ≥ 2 of the following 3 factors derived and modified from the Study of Osteoporotic Fracture Criteria for Frailty: 1) weight loss ≥ 5% over 2 years, 2) inability to do chair stands, and 3) answer of “no” to the question “Do you feel full of energy?”. Associations between frailty and tooth loss, denture use, and self-perceived denture fit were evaluated using logistic regression analysis. The multivariable models were adjusted for sex, body mass index, and mental health. The frequency of frailty in this study was 8.4%. Multivariable logistic regression indicated that tooth loss (per each additional tooth present, adjusted odds ratio [OR]=0.94; 95% confidence interval [CI]=0.90–0.99), the presence of 20 teeth or more (compared with the presence of less than 20 teeth, adjusted OR=0.39, 95% CI=0.15–0.97), denture non-use (compared with denture use, adjusted OR=17.89, 95% CI=5.00–64.32), and self-perceived ill-fitting denture (compared with well-fitting denture, adjusted OR=3.38, 95% CI=1.01–11.27) were significantly correlated with frailty. Our results suggest that tooth loss, denture non-use, and self-perceived ill-fitting denture were associated with frailty in community-dwelling older Japanese adults.

DOI： 10.5834/jdh.68.2_68

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Relationship between Self-rated Tooth and Gingival Health and Self-rated General Health among General Japanese Subjects: The 8020 Health Study

MINAGAWA Kumiko, MIYAZAKI Hideo, YOSHIHARA Akihiro, SATO Misuzu, FUKAI Kakuhiro, ANDO Yuichi, SHIMAZAKI Yoshihiro, FURUTA Michiko, AIDA Jun, KANBARA Masaki

JOURNAL OF DENTAL HEALTH 68 ( 4 ) 198 - 206 2018

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Language：Japanese Publisher：Japanese Society for Oral Health

 Self-rated health is a simple way of assessing the health status. It is also used for oral health research in general population surveys. However, limited information is available on younger populations aged under 65 years. Accordingly, the aim of this cross-sectional study was to investigate the association between the self-rated tooth and gingival health and self-rated general health based on a survey conducted by the 8020 Promotion Foundation in 2015. For this survey, questionnaires were mailed to 5,000 people, aged 20 to 79, who were selected by stratified two-stage random sampling from Japanese municipalities, and 2,465 people responded (response rate=49.3%). Data without missing responses from 1,972 participants were used for analysis. The subjects were divided into three groups according to age: young participants (aged 20-39 years), middle-aged participants (aged 40-59 years), and elderly participants (aged 60-79 years). An ordinal logistic regression model was created to evaluate the association between self-rated tooth and gingival health and self-rated general health for each group. Multivariable models were adjusted for the number of teeth, sex, employment status, subjective economic status, education, comorbidity, presence of an adviser, and body mass index. Based on the ordinal logistic regression analysis, participants with good self-rated tooth and gingival health had significantly better self-rated general health. The adjusted odds ratio (95% confidence interval) was 12.41 (7.22-21.34) for the young participants, 11.77 (7.50-18.48) for the middle-aged participants, and 10.07 (6.55-15.50) for the elderly participants. The present study suggests that the self-rated tooth and gingival health is significantly correlated with self-rated general health among general Japanese subjects in all age groups.

DOI： 10.5834/jdh.68.4_198

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Association between Eating Assessment Tool-10 (EAT-10) and the Health, Dental, and Nutritional Status of Elderly Individuals Living at Home

AKIYAMA Rika, HAMASAKI Tomoko, SAKAI Rie, IWASAKI Masanori, KAKUTA Satoko, SOH Inho, YOSHIHARA Akihiro, MIYAZAKI Hideo, ANSAI Toshihiro

JOURNAL OF DENTAL HEALTH 68 ( 2 ) 76 - 84 2018

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Language：Japanese Publisher：Japanese Society for Oral Health

 This study investigated the relationship between dysphagia and the nutritional status of elderly individuals living at home when screened with Eating Assessment Tool-10 (EAT-10). A total of 129 participants (62 males, 67 females, aged 85 years) were surveyed. Participants were sent a questionnaire by mail and asked to complete and return it to the authors. Assessments included in the questionnaire were EAT-10, the self-reported number of teeth, Short-form Mini Nutritional Assessment (MNA-SF), a subjective health evaluation, Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-Index of Competence), Oral Health Impact Profile-49 (OHIP), and number of foods that can be masticated. To evaluate variation in the study's variables, the analysis was based on established scores of EAT-10: those suspected of having dysphagia score above three; those with no suspicion of dysphagia score below two. When screened with EAT-10, 52.7% of the participants were classified as being suspected of having dysphagia. There were significant correlations between dysphagia and a low OHIP score (p<0.001), the number of foods that can be masticated (p<0.001), subjective health evaluation (p<0.001), and MNA-SF (p=0.007). Furthermore, logistic regression analysis revealed that the nutritional status was associated with dysphagia (p=0.043)．These findings suggest the association of dysphagia with malnutrition in elderly people living at home.

DOI： 10.5834/jdh.68.2_76

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Other Link： http://search.jamas.or.jp/link/ui/2018250456
Dental caries prevalence and treatment level of neglected children at two child guidance centers Reviewed

Yukiko Nogami, Yoko Iwase, Akiko Kagoshima, Issei Saitoh, Tsutomu Nakajima, Hideki Takahashi, Kanehito Nakagawa, Akihiro Yoshihara, Akitsugu Ohuchi, Tomiko Asahito, Haruaki Hayasaki

Pediatric Dental Journal 27 ( 3 ) 137 - 141 2017.12

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DOI： 10.1016/j.pdj.2017.08.003

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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults Reviewed

Majid Ezzati, James Bentham, Mariachiara Di Cesare, Ver Bilano, Honor Bixby, Bin Zhou, Gretchen A. Stevens, Leanne M. Riley, Cristina Taddei, Kaveh Hajifathalian, Yuan Lu, Stefan Savin, Melanie J. Cowan, Christopher J. Paciore, Adela Chirita-Emandi, Alison J. Hayes, Joanne Katz, Roya Kelishadi, Andre Pascal Kengne, Young-Ho Khang, Avula Laxmaiah, Yanping Li, Jun Ma, J. Jaime Miranda, Aya Mostafa, Martin Neovius, Cristina Padez, Lekhraj Rampal, Aubrianna Zhu, James E. Bennet, Goodarz Danaei, Zulfiqar A. Bhutta, Majid Ezzati, Leandra Abarca-Gomez, Ziad A. Abdeen, Zargar Abdul Hamid, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Cecilia Acuin, Robert J. Adams, Wichai Aekplakorn, Kaosar Afsana, Carlos A. Aguilar-Salinas, Charles Agyemng, Alireza Ahmadvand, Wolfgang Ahrens, Kamel Ajlouni, Nazgul Akhtaeva, Hazzaa M. Al-Hazzaa, Amani Rashed Al-Othman, Rajaa Al-Raddadi, Fadia AlBuhairan, Shahla AlDhukai, Mohamed M. Ali, Osman Ali, Ala'a Alkerwi, Mar Alvarez-Pedrerol, Eman Aly, Deepak N. Amarapurkar, Philippe Amouyel, Antoinette Amuzu, Lars Bo Andersen, Sigmund A. Anderssen, Dolores S. Andrade, Lars H. Angquist, Ranjit Mohan Anjana, Hajer Aounallah-Skhiri, Joana Araujo, Inger Arianse, Tahir Aris, Nimmathota Arlappa, Dominique Arveiler, Krishna K. Aryal, Thor Aspelund, Felix K. Assah, Maria Cecilia F. Assuncao, May Soe Aung, Maria Avdicova, Ana Azevedo, Fereidoun Azizi, Bontha V. Babu, Suhad Bahijri, Jennifer L. Baker, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, Jose R. Banegas, Carlo M. Barbagallo, Alberto Barcelo, Amina Barkat, Aluisio J. D. Barros, Mauro V. G. Barros, Iqbal Bata, Anwar M. Batieha, Rosangela L. Batista, Assembekov Batyrbek, Louise A. Baur, Robert Beaglehole, Habiba Ben Romdhane, Judith Benedics, Mikhail Benet, James E. Bennet, Antonio Bernabe, Gailute Bernotiene, Heloisa Bettiol, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K. Bhargava, Zaid Bhatti, Zulfiqar A. Bhutta, Hongsheng Bi, Yufang Bi, Anna Biehl, Mukharram Bikbov, Bihungum Bista, Dusko J. Bjelica, Peter Bjerregaard, Espen Bjertnes, Marius B. Bjness, Cecilia Bjorkelund, Anneke Blokstra, Simona Bo, Martin Bobak, Lynne M. Boddy, Bernhard O. Boehm, Heiner Boeing, Jose G. Boggia, Carlos P. Boissonnet, Marialaura Bonaccio, Vanina Bongard, Pascal Bovet, Lien Braeckevelt, Lutgart Braeckman, Marjolijn C. E. Bragt, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, Joao Breda, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Lacramioara Brinduse, Graziella Bruno, H. B. Bueno-de-Mesquita, Anna Bugge, Marta Buoncristiano, Genc Burazeri, Con Burns, Antonio Cabrera de Leon, Joseph Cacciottolo, Hui Cai, Tilema Cama, Christine Cameron, Jose Camola, Gunay Can, Ana P. C. C. Candido, Mario Capanzana, Vincenzo Capuano, Viviane C. Cardoso, Axel C. Carlsson, Maria J. Carvalho, Felipe F. Casanueva, Juan Pablo Casas, Carmelo A. Caserta, Snehalatha Chamukuttan, Angelique W. Chan, Queenie Chan, Himanshu K. Chaturvedi, Nishi Chaturvedi, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Angela Chetrit, Ekaterina Chikova-Iscener, Arnaud Chiolero, Shu-Ti Chiou, Maria-Dolores Chirlaque, Belong Cho, Yumi Cho, Kaare Christensen, Diego G. Christofaro, Jerzy Chudek, Renata Cifkova, Eliza Cinteza, Frank Claessens, Els Clays, Hans Concin, Susana C. Confortin, Cyrus Cooper, Rachel Cooper, Tara C. Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L. Craig, Ana B. Crujeiras, Alexandra Cucu, Graziella D'Arrigo, Eleonora d'Orsi, Jean Dallongeville, Albertino Damasceno, Camilla T. Damsgaard, Goodarz Danae, Rachel Dankner, Thomas M. Dantoft, Saeed Dastgiri, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Amalia De Curtis, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, Karin De Ridder, Delphine De Smedt, Mohan Deepa, Alexander D. Deev, Abbas Dehghan, Helene Delisle, Francis Delpeuch, Valerie Deschamps, Klodian Dhana, Augusto F. Di Castelnuovo, Juvenal Soares Dias-da-Costa, Alejandro Diaz, Zivka Dika, Shirin Djalalinia, Ha T. P. Do, Annette J. Dobson, Maria Benedetta Donati, Chiara Donfrancesco, Silvana P. Donoso, Angela Doering, Maria Dorobantu, Ahmad Reza Dorosty, Kouamelan Doua, Wojciech Drygas, Jia Li Duan, Charmaine Duante, Vesselka Duleva, Virginija Dulskiene, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Eruke E. Egbagbe, Robert Eggertsen, Gabriele Eiben, Ulf Ekelund, Jalila El Ati, Paul Elliott, Reina Engle-Stone, Rajiv T. Erasmus, Cihangir Erem, Louise Eriksen, Johan G. Eriksson, Jorge Escobedo, Alun Evans, David Faeh, Caroline H. Fall, Victoria Farrugia Sant'Angelo, Farshad Farzadfar, Francisco J. Felix-Redondo, Trevor S. Ferguson, Romulo A. Fernandes, Daniel Fernandez-Berges, Daniel Ferrante, Marika Ferrari, Catterina Ferreccio, Jean Ferrieres, Joseph D. Finn, Krista Fischer, Eric Monterubio Flores, Bernhard Foeger, Leng Huat Foo, Ann-Sofie Forslund, Maria Forsner, Heba M. Fouad, Damian K. Francis, Maria do Carmo Franco, Oscar H. Franco, Guillermo Frontera, Flavio D. Fuchs, Sandra C. Fuch, Yuki Fujita, Takuro Furusawa, Zbigniew Gaciong, Mihai Gafencu, Daniela Galeone, Fabio Galvano, Manoli Garcia-de-la-Hera, Dickman Gareta, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Harald Geiger, Johanna M. Geleijnse, Anoosheh Ghasemian, Simona Giampaoli, Francesco Gianfagna, Tiffany K. Gill, Jonathan Giovannelli, Aleksander Giwerman, Justyna Godos, Sibel Gogen, Rebecca A. Goldsmith, David Goltzman, Helen Goncalves, Margot Gonzalez-Leon, Juan P. Gonzalez-Rivas, Marcela Gonzalez-Gross, Frederic Gottrand, Antonio Pedro Graca, Sidsel Graff-Iversen, Dusan Grafnetter, Aneta Grajda, Maria G. Grammatikopoulou, Ronald D. Gregor, Tomasz Grodzicki, Anders Grontved, Giuseppe Grosso, Gabriella Gruden, Vera Grujic, Dongfeng Gu, Emanuela Gualdi-Russo, Pilar Guallar-Castillon, Ong Peng Guan, Elias F. Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L. Guimaraes, Martin C. Gulliford, Johanna Gunnlaugsdottir, Marc Gunter, Xiuhua Guo, Yin Guo, Prakash C. Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Farzad Hadaegh, Charalambos A. Hadjigeorgiou, Khairil Si-Ramlee, Jytte Halkjaer, Ian R. Hambleton, Rebecca Hardy, Rachakulla Hari Kumar, Maria Hassapidou, Jun Hata, Alison J. Hayes, Jiang He, Regina Heidinger-Felso, Mirjam Heinen, Marleen Elisabeth Hendriks, Ana Henriques, Leticia Hernandez Cadena, Sauli Herrala, Victor M. Herrera, Isabelle Herter-Aeberli, Ramin Heshmat, Ilpo Tapani Hihtaniemi, Sai Yin Ho, Suzanne C. Ho, Michael Hobbs, Albert Hofman, Wilma M. Hopman, Andrea R. V. R. Horimoto, Claudia M. Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, Jose Maria Huerta, Constanta Huidumac Petrescu, Martijn Huisman, Abdullatif Husseini, Chinh Nguyen Huu, Inge Huybrechts, Nahla Hwalla, Jolanda Hyska, Licia Iacoviello, Anna G. Iannone, Jesus M. Ibarluzea, Mohsen M. Ibrahim, Nayu Ikeda, M. Arfan Ikram, Vilma E. Irazola, Muhammad Islam, Aziz al-Safi Ismail, Vanja Ivkovic, Masanori Iwasaki, Rod T. Jackson, Jeremy M. Jacobs, Hashem Jaddou, Tazeen Jafar, Kazi M. Jamil, Konrad Jamrozik, Imre Janszky, Juel Jarani, Grazyna Jasienska, Ana Jelakovic, Bojan Jelakovic, Garry Jennings, Seung-Lyeal Jeong, Chao Qiang Jiang, Santa Magaly Jimenez-Acosta, Michel Joffres, Mattias Johansson, Jost B. Jonas, Torben Jorgensen, Pradeep Joshi, Dragana P. Jovic, Jacek Jozwiak, Anne Juolevi, Gregor Jurak, Vesna Juresa, Rudolf Kaaks, Anthony Kafatos, Eero O. Kajantie, Ofra Kalter-Leibovici, Nor Azmi Kamaruddin, Efthymios Kapantais, Khem B. Karki, Amir Kasaeian, Joanne Katz, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinanen-Kiukaanniemi, Roya Kelishadi, Cecily Kelleher, Han C. G. Kemper, Andre P. Kengne, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Ousef Saleh Khader, Davood Khalili, Young-Ho Khang, Mohammad Khateeb, Kay-Tee Khaw, Ilse M. S. L. Khouw, Ursula Kiechl-Kohlendorfer, Stefan Kiech, Japhet Killewo, Jeongseon Kim, Yeon-Yong Kim, Jeannette Klimont, Jurate Klumbiene, Michael Knoflach, Bhawesh Koirala, Elin Kolle, Patrick Kolsteren, Paul Korrovits, Jelena Kos, Seppo Koskinen, Katsuyasu Kouda, Viktoria A. Kovacs, Sudhir Kowlessur, Slawomir Koziel, Wolfgang Kratzer, Susi Kriemler, Peter Lund Kristensen, Steinar Krokstad, Daan Kromhout, Herculina S. Kruger, Ruzena Kubinova, Renata Kuciene, Diana Kuh, Urho M. Kujala, Zbigniew Kulaga, R. Krishna Kumar, Marie Kunesova, Pawel Kurjata, Yadlapalli S. Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Quang Ngoc La, Fatima Zahra Laamiri, Tina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Bagher Larijani, Lars E. Laugsand, Laura Lauria, Avula Laxmaiah, Khanh Le Nguyen Bao, Tuyen D Le, May Antonnette O. Lebanan, Catherine Leclercq, Jeannette Lee, Jeonghee Lee, Terho Lehtimaki, Luz M. Leon-Munoz, Naomi S. Levitt, Yanping Li, Christa L. Lilly, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Lars Lind, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Jing Liu, Helle-Mai Loit, Luis Lopes, Roberto Lorbeer, Paulo A. Lotufo, Jose Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Per Lytsy, Guansheng Ma, Jun Ma, George L. L. Machado-Coelho, Aristides M. Machado-Rodrigues, Suka Machi, Stefania Maggi, Dianna J. Magliano, Emmanuella Magriplis, Alagappan Mahaletchumy, Bernard Maire, Marjeta Majer, Marcia Makdisse, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Yannis Manios, Jim I. Mann, Enzo Manzato, Paula Margozzini, Anastasia Markaki, Oonagh Markey, Larissa P. Marques, Pedro Marques-Vidal, Jaume Marrugat, Yves Martin-Prevel, Rosemarie Martin, Reynaldo Martorell, Eva Martos, Stefano Marventano, Shariq R. Masoodi, Ellisiv B. Mathiesen, Alicia Matijasevich, Tandi E. Matsha, Artur Mazur, Jean Claude N. Mbanya, Shelly R. McFarlane, Stephen T. McGarvey, Martin McKee, Stela McLac, Rachael M. McLean, Scott B. McLean, Breige A. McNulty, Safiah Md Yusof, Sounnia Mediene-Benchekor, Jurate Medzioniene, Aline Meirhaeghe, Jorgen Meisfjord, Christa Meisinger, Ana Maria B. Menezes, Geetha R. Menon, Gert B. M. Mensink, Indrapal I. Meshram, Andres Metspalu, Haakon E. Meyer, Jie Mi, Kim F. Michaelsen, Nathalie Michels, Kairit Mikkel, Jody C. Miller, Claudia S. Minderico, Juan Francisco Miquel, J. Jaime Miranda, Daphne Mirkopoulou, Erkin Mirrakhimov, Marjeta Misigoj-Durakovic, Antonio Mistretta, Veronica Mocanu, Pietro A. Modesti, Mostafa K. Mohamed, Kazem Mohammad, Noushin Mohammadifard, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Drude Molbo, Line T. Mollehave, Niels C. Moller, Denes Molnar, Amirabbas Momenan, Charles K. Mondo, Eric A. Monterrubio, Kotsedi Daniel K. Monyeki, Jin Soo Moon, Leila B. Moreira, Alain Morejo, Luis A. Moreno, Karen Morgan, Erik Lykke Mortensen, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Anabela Mota-Pinto, Mohammad Esmaeel Motlag, Jorge Motta, Thet Thet Mu, Magdalena Muc, Maria Lorenza Muiesan, Martina Mueller-Nurasyid, Neil Murphy, Jaakko Mursu, Elaine M. Murtagh, Vera Musil, Iraj Nabipour, Gabriele Nagel, Balkish M. Naidu, Harunobu Nakamura, Jana Namesna, Ei Ei K. Nang, Vinay B. Nangia, Martin Nankap, Sameer Narake, Paola Nardone, Eva Maria Navarrete-Munoz, William A. Neal, Ilona Nenko, Martin Neovius, Flavio Nervi, Chung T. Nguyen, Nguyen D. Nguyen, Quang Ngoc Nguye, Ramfis E. Nieto-Martinez, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Oscar A. Noboa, Teresa Norat, Sawada Norie, Davide Noto, Mohannad Al Nsour, Dermot O'Reilly, Galina Obreja, Eiji Oda, Glenn Oehlers, Kyungwon Oh, Kumiko Ohara, Orn Olafsson, Maria Teresa Anselmo Olinto, Isabel O. Oliveira, Maciej Oltarzewski, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Lariane M. Ono, Pedro Ordunez, Rui Ornelas, Ana P. Ortiz, Merete Osler, Clive Osmond, Sergej M. Ostojic, Afshin Ostovar, Johanna A. Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Elena Pahomova, Andrzej Pajak, Domenico Palli, Alberto Palloni, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Arvind Pandey, Francesco Panza, Dimitrios Papandreou, Soon-Woo Park, Winsome R. Parnell, Mahboubeh Parsaeian, Ionela M. Pascanu, Nikhil D. Patel, Ivan Pecin, Mangesh S. Pednekar, Nasheeta Peer, Petra H. Peeters, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Napoleon Perez-Farinos, Cynthia M. Perez, Annette Peters, Janina Petkeviciene, Ausra Petrauskiene, Niloofar Peykari, Son Thai Pham, Daniela Pierannunzio, Iris Pigeo, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Francesco Pistelli, Freda Pitakaka, Aleksandra Piwonska, Pedro Plans-Rubio, Bee Koon Poh, Hermann Pohlabeln, Raluca M. Pop, Stevo R. Popovic, Miquel Porta, Marileen L. P. Portegies, Georg Posch, Dimitrios Poulimeneas, Hamed Pouraram, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Mathur Prashant, Jacqueline F. Price, Jardena J. Puder, Iveta Pudule, Maria Puiu, Margus Punab, Radwan F. Qasrawi, Mostafa Qorbani, Tran Quoc Bao, Ivana Radic, Ricardas Radisauskas, Mahfuzar Rahman, Mahmudur Rahman, Olli Raitakari, Manu Raj, Sudha Ramachandra Rao, Ambady Ramachandran, Jacqueline Ramke, Elisabete Ramos, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Ramon A. Rascon-Pacheco, Josep Redon, Paul Ferdinand M. Reganit, Lourdes Ribas-Barba, Robespierre Ribeiro, Elio Riboli, Fernando Rigo, Tobias F. Rinke de Wit, Ana Rito, Raphael M. Ritti-Dias, Juan A. Rivera, Sian M. Robinson, Cynthia Robitaille, Daniela Rodrigues, Fernando Rodriguez-Artalejo, Maria del Cristo Rodriguez-Perez, Laura A. Rodriguez-Villamizar, Rosalba Rojas-Martinez, Nipa Rojroongwasinkul, Dora Romaguera, Kimmo Ronkainen, Annika Rosengren, Ian Rouse, Joel G. R. Roy, Adolfo Rubinstein, Frank J. Ruhli, Blanca Sandra Ruiz-Betancourt, Paola Russo, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S. Sachdev, Olfa Saidi, Benoit Salanave, Eduardo Salazar Martinez, Diego Salmeron, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Jose Sanchez-Abanto, Sandjaja, Susana Sans, Loreto Santa Marina, Diana A. Santos, Ina S. Santos, Osvaldo Santos, Renata Nunes dos Santos, Rute Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Savvas Savva, Mathilde Savy, Marcia Scazufca, Angelika Schaffrath Rosario, Herman Schargrodsky, Anja Schienkiewitz, Sabine Schipf, Carsten O. Schmidt, Ida Maria Schmidt, Constance Schultsz, Aletta E. Schutte, Aye Aye Sein, Abhijit Sen, Idowu O. Senbanjo, Sadaf G. Sepanlou, Luis Serra-Majem, Svetlana A. Shalnova, Sanjib K. Sharma, Jonathan E. Shaw, Kenji Shibuya, Dong Wook Shin, Youchan Shin, Rahman Shiri, Alfonso Siani, Rosalynn Siantar, Abla M. Sibai, Antonio M. Silva, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Agneta Sjoberg, Michael Sjostrom, Sine Skovbjerg, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Margaret C. Smith, Marieke B. Snijder, Hung-Kwan So, Eugene Sobngwi, Stefan Soderberg, Moesijanti Y. E. Soekatri, Vincenzo Solfrizzi, Emily Sonestedt, Yi Song, Thorkild I. A. Sorensen, Maroje Soric, Charles Sossa Jerome, Aicha Soumare, Angela Spinelli, Igor Spiroski, Jan A. Staessen, Hanspeter Stamm, Gregor Starc, Maria G. Stathopoulou, Kaspar Staub, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, George S. Stergiou, Jochanan Stessman, Jutta Stieber, Doris Stockl, Tanja Stocks, Jakub Stokwisze, Gareth Stratton, Karien Stronks, Maria Wany Strufaldi, Ramon Suarez-Medina, Chien-An Sun, Johan Sundstrom, Yn-Tz Sung, Jordi Sunyer, Paibul Suriyawongpaisa, Boyd A. Swinburn, Rody G. Sy, Lucjan Szponar, E. Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Jakob Tarp, Carolina B. Tarqui-Mamani, Oana-Florentina Tautu, Radka Taxova Braunerova, Anne Taylor, Felicite Tchibindat, Holger Theobald, Xenophon Theodoridis, Lutgarde Thijs, Betina H. Thuesen, Anne Tjonneland, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Roman Topor-Madry, Maria Jose Tormo, Michael J. Tornaritis, Maties Torrent, Stefania Toselli, Pierre Traissac, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh T. H. Trinh, Atul Trivedi, Lechaba Tshepo, Maria Tsigga, Shoichiro Tsugane, Marshall K. Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L. Turley, Per Tynelius, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Eunice E. Ugel, Flora A. M. Ukoli, Hanno Ulmer, Belgin Unal, Hannu M. T. Uusitalo, Gonzalo Valdivia, Susana Vale, Damaskini Valvi, Yvonne T. van der Schouw, Koen Van Herck, Hoang Van Minh, Lenie van Rossem, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Lars Vatten, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Biruta Velika, Giovanni Veronesi, W. M. Monique Verschuren, Cesar G. Victora, Giovanni Viegi, Lucie Viet, Eira Viikari-Juntura, Paolo Vineis, Jesus Vioque, Jyrki K. Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Tiina Vlasoff, Peter Vollenweider, Henry Voelzke, Sari Voutilainen, Martine Vrijheid, Alisha N. Wade, Aline Wagner, Thomas Waldhor, Janette Walton, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo S. Wanderley, Ming-Dong Wang, Qian Wan, Ya Xing Wang, S. Goya Wannamethee, Nicholas Wareham, Adelheid Weber, Niels Wedderkopp, Deepa Weerasekera, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Wiecek, Alet H. Wijga, Rainford J. Wilks, Johann Willeit, Peter Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Roy A. Wong-McClure, Justin Y. Y. Wong, Jyh Eiin Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C. Wu, Jianfeng Wu, Shouling Wu, Haiquan Xu, Liang Xu, Uruwan Yamborisut, Weili Yan, Xiaoguang Yang, Nazan Yardim, Xingwang Ye, Panayiotis K. Yiallouros, Agneta Yngve, Akihiro Yoshihara, Qi Sheng You, Novie O. Younger-Coleman, Faudzi Yusoff, Muhammad Fadhli M. Yusoff, Luciana Zaccagni, Vassilis Zafiropulos, Ahmad A. Zainuddin, Sabina Zambon, Antonis Zampelas, Hana Zamrazilova, Tomasz Zdrojewski, Yi Zeng, Dong Zhao, Wenhua Zhao, Wei Zheng, Yingfeng Zheng, Bekbolat Zholdin, Maigeng Zhou, Dan Zhu, Baurzhan Zhussupov, Esther Zimmermann, Julio Zuniga Cisneros

LANCET 390 ( 10113 ) 2627 - 2642 2017.12

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DOI： 10.1016/S0140-6736(17)32129-3

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高齢者における口腔と栄養

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ヘルスサイエンス・ヘルスケア 17 ( 2 ) 46 - 52 2017.12

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老年歯科医学 32 ( 2 ) 134 - 135 2017.9

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日本老年歯科医学会総会・学術大会プログラム・抄録集 28回 155 - 155 2017.6

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地域在住高齢者における最大咬合力とフレイルとの関連 5年間の前向きコホート研究

岩崎正則, 葭原明弘, 佐藤直子, 佐藤美寿々, 安細敏弘, 小野高裕, 宮崎秀夫

日本老年歯科医学会総会・学術大会プログラム・抄録集 28回 131 - 131 2017.6

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Relationship between renal function and periodontal disease in community-dwelling elderly women with different genotypes

Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Yanming Wang, Hideo Miyazaki, Hiromasa Yoshie, Kazutoshi Nakamura

JOURNAL OF CLINICAL PERIODONTOLOGY 44 ( 5 ) 484 - 489 2017.5

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DOI： 10.1111/jcpe.12708

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Malnutrition and Oral Disease in the Elderly––Is There Any Bidirectional Relationship?

Masanori Iwasaki, Misuzu Sato, Akihiro Yoshihara, Hideo Miyazaki

Current Oral Health Reports 4 ( 2 ) 70 - 78 2017.4

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DOI： 10.1007/s40496-017-0127-1

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地域高齢者における平衡機能と口腔機能の関連

小田島あゆ子, 葭原明弘, 石上和男, 笹嶋真嵩, 野々村絢子, 宮崎秀夫

口腔衛生学会雑誌 67 ( 増刊 ) 117 - 117 2017.4

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地域在住高齢者における健康習慣と歯の喪失・歯周病リスクの関連

岩崎正則, 葭原明弘, 佐藤美寿々, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 67 ( 増刊 ) 116 - 116 2017.4

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Current status of tooth loss and relationship between the use of dentures and activities of daily living in individuals with mental retardation Reviewed

米澤大輔, 石川裕子, 葭原明弘

日本歯科衛生学会雑誌 11 ( 2 ) 32 - 39 2017.2

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Association between tooth loss and medical costs related to stroke in healthy older adults aged over 75 years in Japan

Masanori Iwasaki, Misuzu Sato, Akihiro Yoshihara, Toshihiro Ansai, Hideo Miyazaki

GERIATRICS & GERONTOLOGY INTERNATIONAL 17 ( 2 ) 202 - 210 2017.2

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DOI： 10.1111/ggi.12687

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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants Reviewed

Bin Zhou, James Bentham, Mariachiara Di Cesare, Honor Bixby, Goodarz Danaei, Melanie J. Cowan, Christopher J. Paciorek, Gitanjali Singh, Kaveh Hajifathalian, James E. Bennett, Cristina Taddei, Ver Bilano, Rodrigo M. Carrillo-Larco, Shirin Djalalinia, Shahab Khatibzadeh, Charles Lugero, Niloofar Peykari, Wan Zhu Zhang, Yuan Lu, Gretchen A. Stevens, Leanne M. Riley, Pascal Bovet, Paul Elliott, Dongfeng Gu, Nayu Ikeda, Rod T. Jackson, Michel Joffres, Andre Pascal Kengne, Tiina Laatikainen, Tai Hing Lam, Avula Laxmaiah, Jing Liu, J. Jaime Miranda, Charles K. Mondo, Hannelore K. Neuhauser, Johan Sundstrom, Liam Smeeth, Maroje Soric, Mark Woodward, Majid Ezzati, Leandra Abarca-Gomez, Ziad A. Abdeen, Hanan Abdul Rahim, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Robert Adams, Wichai Aekplakorn, Kaosar Afsana, Carlos A. Aguilar-Salinas, Charles Agyemang, Alireza Ahmadvand, Wolfgang Ahrens, Rajaa Al Raddadi, Rihab Al Woyatan, Mohamed M. Ali, Ala'a Alkerwi, Eman Aly, Philippe Amouyel, Antoinette Amuzu, Lars Bo Andersen, Sigmund A. Anderssen, Lars Angquist, Ranjit Mohan Anjana, Daniel Ansong, Hajer Aounallah-Skhiri, Joana Araujo, Inger Ariansen, Tahir Aris, Nimmathota Arlappa, Krishna Aryal, Dominique Arveiler, Felix K. Assah, Maria Cecilia F. Assuncao, Maria Avdicova, Ana Azevedo, Fereidoun Azizi, Bontha V. Babu, Suhad Bahijri, Nagalla Balakrishna, Piotr Bandosz, Jose R. Banegas, Carlo M. Barbagallo, Alberto Barcelo, Amina Barkat, Aluisio J. D. Barros, Mauro V. Barros, Iqbal Bata, Anwar M. Batieha, Louise A. Baur, Robert Beaglehole, Habiba Ben Romdhane, Mikhail Benet, Lowell S. Benson, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloisa Bettiol, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K. Bhargava, Yufang Bi, Mukharram Bikbov, Peter Bjerregaard, Espen Bjertness, Cecilia Bjokelund, Anneke Blokstra, Simona Bo, Martin Bobak, Heiner Boeing, Jose G. Boggia, Carlos P. Boissonnet, Vanina Bongard, Pascal Bovet, Lutgart Braeckman, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, Hermann Brenner, Lizzy M. Brewster, Graziella Bruno, H. B. (as) Bueno-de-Mesquita, Anna Bugge, Con Burns, Michael Bursztyn, Antonio Cabrera de Leon, Christine Cameron, Gunay Can, Ana Paula C. Candido, Vincenzo Capuano, Viviane C. Cardoso, Axel C. Carlsson, Maria J. Carvalho, Felipe F. Casanueva, Felipe F. Casanueva, Juan-Pablo Casas, Carmelo A. Caserta, Snehalatha Chamukuttan, Angelique W. Chan, Queenie Chan, Himanshu K. Chaturvedi, Nishi Chaturvedi, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Imane Cherkaoui Dekkaki, Angela Chetrit, Arnaud Chiolero, Shu-Ti Chiou, Adela Chirita-Emandi, Belong Cho, Yumi Cho, Jerzy Chudek, Renata Cifkova, Frank Claessens, Els Clays, Hans Concin, Cyrus Cooper, Rachel Cooper, Tara C. Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L. Craig, Ana B. Crujeiras, Juan J. Cruz, Graziella D'Arrigo, Eleonora d'Orsi, Jean Dallongeville, Albertino Damasceno, Goodarz Danaei, Rachel Dankner, Thomas M. Dantoft, Luc Dauchet, Guy De Backer, Giovanni de Gaetano, Stefaan De Henauw, Delphine De Smedt, Mohan Deepa, Abbas Dehghan, Helene Delisle, Valerie Deschamps, Klodian Dhana, Augusto F. Di Castelnuovo, Juvenal Soares Dias-da-Costa, Alejandro Diaz, Ty T. Dickerson, Shirin Djalalinia, Ha T. P. Do, Annette J. Dobson, Chiara Donfrancesco, Silvana P. Donoso, Angela Doering, Kouamelan Doua, Wojciech Drygas, Virginija Dulskiene, Aleksandar Dzakula, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Robert Eggertsen, Ulf Ekelund, Jalila El Ati, Ute Ellert, Paul Elliott, Roberto Elosua, Rajiv T. Erasmus, Cihangir Erem, Louise Eriksen, Jorge Escobedo-de la Pena, Alun Evans, David Faeh, Caroline H. Fall, Farshad Farzadfar, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernandez-Berges, Daniel Ferrante, Marika Ferrari, Catterina Ferreccio, Jean Ferrieres, Joseph D. Finn, Krista Fischer, Bernhard Foeger, Leng Huat Foo, Ann-Sofie Forslund, Maria Forsner, Stephen P. Fortmann, Heba M. Fouad, Damian K. Francis, Maria do Carmo Franco, Oscar H. Franco, Guillermo Frontera, Flavio D. Fuchs, Sandra C. Fuchs, Yuki Fujita, Takuro Furusawa, Zbigniew Gaciong, Dickman Gareta, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Diana Gavrila, Johanna M. Geleijnse, Anoosheh Ghasemian, Anup Ghimire, Simona Giampaoli, Francesco Gianfagna, Jonathan Giovannelli, Rebecca A. Goldsmith, Helen Goncalves, Marcela Gonzalez Gross, Juan P. Gonzalez Rivas, Frederic Gottrand, Sidsel Graff-Iversen, Dusan Grafnetter, Aneta Grajda, Ronald D. Gregor, Tomasz Grodzicki, Anders Grontved, Grabriella Gruden, Vera Grujic, Dongfeng Gu, Ong Peng Guan, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L. Guimaraes, Martin C. Gulliford, Johanna Gunnlaugsdottir, Marc Gunter, Prakash C. Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Farzad Hadaegh, Jytte Halkjaer, Ian R. Hambleton, Rebecca Hardy, Rachakulla Harikumar, Jun Hata, Alison J. Hayes, Jiang He, Marleen Elisabeth Hendriks, Ana Henriques, Leticia Hernandez Cadena, Herqutanto, Sauli Herrala, Ramin Heshmat, Ilpo Tapani Hihtaniemi, Sai Yin Ho, Suzanne C. Ho, Michael Hobbs, Albert Hofman, Gonul Horasan Dinc, Claudia M. Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Yonghua Hu, Jose Maria Huerta, Abdullatif S. Husseini, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G. Iannone, M. Mohsen Ibrahim, M. Arfan Ikram, Vilma E. Irazola, Muhammad Islam, Vanja Ivkovic, Masanori Iwasaki, Rod T. Jackson, Jeremy M. Jacobs, Tazeen Jafar, Konrad Jamrozik, Imre Janszky, Grazyna Jasienska, Bojan Jelakovic, Chao Qiang Jiang, Mattias Johansson, Jost B. Jonas, Torben Jorgensen, Pradeep Joshi, Anne Juolevi, Gregor Jurak, Vesna Juresa, Rudolf Kaaks, Anthony Kafatos, Ofra Kalter-Leibovici, Nor Azmi Kamaruddin, Amir Kasaeian, Joanne Katz, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinanen-Kiukaanniemi, Roya Kelishadi, Han C. G. Kemper, Andre Pascal Kengne, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Young-Ho Khang, Kay-Tee Khaw, Stefan Kiechl, Japhet Killewo, Jeongseon Kim, Jurate Klumbiene, Elin Kolle, Patrick Kolsteren, Paul Korrovits, Seppo Koskinen, Katsuyasu Kouda, Slawomir Koziel, Peter Lund Kristensen, Steinar Krokstad, Daan Kromhout, Herculina S. Kruger, Ruzena Kubinova, Renata Kuciene, Diana Kuh, Urho M. Kujala, Krzysztof Kula, Zbigniew Kulaga, R. Krishna Kumar, Pawel Kurjata, Yadlapalli S. Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Tiina Laatikainen, Carl Lachat, Orlando Landrove, Vera Lanska, Georg Lappas, Bagher Larijani, Lars E. Laugsand, Avula Laxmaiah, Khanh Le Nguyen Bao, Tuyen D. Le, Catherine Leclercq, Jeannette Lee, Jeonghee Lee, Terho Lehtimaki, Rampal Lekhraj, Luz M. Leon-Munoz, Naomi S. Levitt, Yanping Li, Christa L. Lilly, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Jing Liu, Roberto Lorbeer, Paulo A. Lotufo, Jose Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Per Lytsy, Guansheng Ma, Jun Ma, George L. L. Machado-Coelho, Suka Machi, Stefania Maggi, Dianna J. Magliano, Marjeta Majer, Marcia Makdisse, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Yannis Manios, Jim I. Mann, Enzo Manzato, Paula Margozzini, Pedro Marques-Vidal, Jaume Marrugat, Reynaldo Martorell, Ellisiv B. Mathiesen, Alicia Matijasevich, Tandi E. Matsha, Jean Claude N. Mbanya, Anselmo J. Mc Donald Posso, Shelly R. McFarlane, Shelly R. McFarlane, Stephen T. McGarvey, Stela McLachlan, Rachael M. McLean, Breige A. McNulty, Amir Sharifuddin Md Khir, Sounnia Mediene-Benchekor, Jurate Medzioniene, Aline Meirhaeghe, Christa Meisinger, Ana Maria B. Menezes, Geetha R. Menon, Indrapal I. Meshram, Andres Metspalu, Jie Mi, Kairit Mikkel, Jody C. Miller, Juan Francisco Miquel, J. Jaime Miranda, Marjeta Misigoj-Durakovic, Mostafa K. Mohamed, Kazem Mohammad, Noushin Mohammadifard, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Niels C. Moller, Denes Molnar, Amirabbas Momenan, Charles K. Mondo, Kotsedi Daniel K. Monyeki, Leila B. Moreira, Alain Morejon, Luis A. Moreno, Karen Morgan, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Maria L. Muiesan, Martina Mueller-Nurasyid, Neil Murphy, Jaakko Mursu, Vera Musil, Gabriele Nagel, Balkish M. Naidu, Harunobu Nakamura, Jana Namsna, Ei Ei K. Nang, Vinay B. Nangia, Sameer Narake, Eva Maria Navarrete-Munoz, Ndeye Coumba Ndiaye, William A. Neal, Ilona Nenko, Flavio Nervi, Hannelore K. Neuhauser, Nguyen D. Nguyen, Quang Ngoc Nguyen, Ramfis E. Nieto-Martinez, Teemu J. Niiranen, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Oscar A. Noboa, Ahmad Ali Noorbala, Teresa Norat, Davide Noto, Mohannad Al Nsour, Dermot O'Reilly, Kyungwon Oh, Maria Teresa A. Olinto, Isabel O. Oliveira, Mohd Azahadi Omar, Altan Onat, Pedro Ordunez, Clive Osmond, Sergej M. Ostojic, Johanna A. Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Elena Pahomova, Andrzej Pajak, Domenico Palli, Luigi Palmieri, Songhomitra Panda-Jonas, Francesco Panza, Dimitrios Papandreou, Winsome R. Parnell, Mahboubeh Parsaeian, Ivan Pecin, Mangesh S. Pednekar, Nasheeta Peer, Petra H. Peeters, Sergio Viana Peixoto, Catherine Pelletier, Markku Peltonen, Alexandre C. Pereira, Rosa Marina Perez, Annette Peters, Janina Petkeviciene, Niloofar Peykari, Son Thai Pham, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Freda Pitakaka, Pedro Plans-Rubio, Maria Polakowska, Ozren Polasek, Miquel Porta, Marileen L. P. Portegies, Akram Pourshams, Rajendra Pradeepa, Mathur Prashant, Jacqueline F. Price, Maria Puiu, Margus Punab, Radwan F. Qasrawi, Mostafa Qorbani, Ivana Radic, Ricardas Radisauskas, Mahfuzar Rahman, Olli Raitakari, Manu Raj, Sudha Ramachandra Rao, Elisabete Ramos, Sanjay Rampal, Daniel A. Rangel Reina, Finn Rasmussen, Josep Redon, Paul Ferdinand M. Reganit, Robespierre Ribeiro, Elio Riboli, Fernando Rigo, Tobias F. Rinke de Wit, Raphael M. Ritti-Dias, Sian M. Robinson, Cynthia Robitaille, Fernando Rodriguez-Artalejo, Laura A. Rodriguez-Villamizar, Rosalba Rojas-Martinez, Annika Rosengren, Adolfo Rubinstein, Ornelas Rui, Blanca Sandra Ruiz-Betancourt, Andrea R. V. Russo Horimoto, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S. Sachdev, Olfa Saidi, Sibel Sakarya, Benoit Salanave, Eduardo Salazar Martinez, Diego Salmeron, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Jose Sanchez-Abanto, Susana Sans, Diana Santos, Ina S. Santos, Renata Nunes dos Santos, Rute Santos, Jouko L. Saramies, Luis B. Sardinha, Giselle Sarganas Margolis, Nizal Sarrafzadegan, Kai-Uwe Saum, Savvas C. Savva, Marcia Scazufca, Herman Schargrodsky, Ione J. Schneider, Constance Schultsz, Aletta E. Schutte, Abhijit Sen, Idowu O. Senbanjo, Sadaf G. Sepanlou, Sanjib K. Sharma, Jonathan E. Shaw, Kenji Shibuya, Dong Wook Shin, Youchan Shin, Rosalynn Siantar, Abla M. Sibai, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjotrom, Sine Skovbjerg, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Margaret C. Smith, Marieke B. Snijder, Hung-Kwan So, Eugene Sobngwi, Stefan Soderberg, Vincenzo Solfrizzi, Emily Sonestedt, Yi Song, Thorkild I. A. Sorensen, Maroje Soric, Charles Sossa Jerome, Aicha Soumare, Jan A. Staessen, Gregor Starc, Maria G. Stathopoulou, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, George S. Stergiou, Jochanan Stessman, Jutta Stieber, Doris Stoeckl, Tanja Stocks, Jakub Stokwiszewski, Karien Stronks, Maria Wany Strufaldi, Chien-An Sun, Johan Sundstrom, Yn-Tz Sung, Paibul Suriyawongpaisal, Rody G. Sy, E. Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Line Tang, Xun Tang, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Carolina B. Tarqui-Mamani, Anne Taylor, Holger Theobald, Lutgarde Thijs, Betina H. Thuesen, Anne Tjonneland, Hanna K. Tolonen, Murat Topbas, Roman Topor-Madry, Maria Jose Tormo, Maties Torrent, Pierre Traissac, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh T. H. Trinh, Atul Trivedi, Lechaba Tshepo, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Maria L. Turley, Per Tynelius, Christophe Tzourio, Peter Ueda, Eunice Ugel, Hanno Ulmer, Hannu M. T. Uusitalo, Gonzalo Valdivia, Damaskini Valvi, Yvonne T. van der Schouw, Koen Van Herck, Lenie van Rossem, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Lars Vatten, Tomas Vega, Gustavo Velasquez-Melendez, Giovanni Veronesi, W. M. Monique Verschuren, Roosmarijn Verstraeten, Cesar G. Victora, Lucie Viet, Eira Viikari-Juntura, Paolo Vineis, Jesus Vioque, Jyrki K. Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Peter Vollenweider, Ana Vrdoljak, Martine Vrijheid, Alisha N. Wade, Aline Wagner, Janette Walton, Wan Nazaimoon Wan Mohamud, Ming-Dong Wang, Qian Wang, Ya Xing Wang, S. Goya Wannamethee, Nicholas Wareham, Niels Wederkopp, Deepa Weerasekera, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Wiecek, Alet H. Wijga, Rainford J. Wilks, Peter Willeit, Emmanuel A. Williams, Tom Wilsgaard, Bogdan Wojtyniak, Tien Yin Wong, Roy A. Wong-McClure, Jean Woo, Mark Woodward, Aleksander Giwercman Wu, Frederick C. Wu, Shou Ling Wu, Haiquan Xu, Weili Yan, Xiaoguang Yang, Xingwang Ye, Panayiotis K. Yiallouros, Akihiro Yoshihara, Novie O. Younger-Coleman, Ahmad F. Yusoff, Sabina Zambon, Tomasz Zdrojewski, Yi Zeng, Dong Zhao, Wenhua Zhao, Yingffeng Zheng, Dan Zhu, Esther Zimmermann, Julio Zuniga Cisneros

LANCET 389 ( 10064 ) 37 - 55 2017.1

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DOI： 10.1016/S0140-6736(16)31919-5

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Malnutrition and oral disease in the elderly – is there any bidirectional relationship? Invited Reviewed

Masanori Iwasaki, Misuzu Sato, Akihiro Yoshihara, Hideo Miyazaki

Current Oral Health Reports 4 ( 2 ) 70 - 78 2017

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Do Community-dwelling 75-year-old People with 20 or More Teeth Have a Healthy Dietary Pattern?

KIMURA Hideki, WATANABE Tomoko, SUZUKI Ayuho, IWASAKI Masanori, YOSHIHARA Akihiro, OGAWA Hiroshi, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 67 ( 3 ) 172 - 180 2017

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The oral health of elderly people is not only important in the maintenance of solid nutrition and articulation but also for their quality of life (QOL). The presence of ≥20 teeth is one of the criteria in the maintenance of the oral function and general health. In 2015, the Ministry of Health, Labour and Welfare of Japan announced the guideline called "Healthy Diet", which supports the longevity of Japanese people. We examined the association between the presence of ≥20 teeth and healthy diet among 75-year-old people. This study included 338 people aged 75 years who participated in the Niigata Elderly Study (2003), in which oral examination, medical checkup, and a brief-type self-administered diet history questionnaire (BDHQ) survey had been carried out. A healthy dietary pattern was defined according to Japan's healthy diet guideline. The healthy diet assumes that one meal consists of three main dishes: grain dish, fish or meat dish, and vegetable dish. For each dish, there are lower and upper limits on the amount of food consumed per meal. For this reason, we set the per-day lower limit as equal to three times the lower limit for a meal. In this study, the sufficiency group satisfied all three dish divisions (i.e., those who achieved a healthy dietary pattern), and the insufficiency group did not meet at least one dish division. The association between the presence of ≥20 teeth and a healthy dietary pattern was evaluated using multivariable logistic regression. As a result, individuals with ≥20 teeth had significantly higher odds of having a healthy dietary pattern (adjusted odds ratio, 1.7; 95% confidence interval: 1.1–2.6). In conclusion, our results suggest that there is a relationship between the presence of ≥20 teeth and meal patterns in elderly people.

DOI： 10.5834/jdh.67.3_172

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Oral health and depression in older Japanese people

Tomoya Takiguchi, Akihiro Yoshihara, Naoko Takano, Hideo Miyazaki

GERODONTOLOGY 33 ( 4 ) 439 - 446 2016.12

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DOI： 10.1111/ger.12177

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Longitudinal association of dentition status with dietary intake in Japanese adults aged 75 to 80 years Reviewed

M. Iwasaki, A. Yoshihara, H. Ogawa, M. Sato, K. Muramatsu, R. Watanabe, T. Ansai, H. Miyazaki

JOURNAL OF ORAL REHABILITATION 43 ( 10 ) 737 - 744 2016.10

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DOI： 10.1111/joor.12427

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Longitudinal relationship of severe periodontitis with cognitive decline in older Japanese Reviewed

M. Iwasaki, A. Yoshihara, Y. Kimura, M. Sato, T. Wada, R. Sakamoto, Y. Ishimoto, E. Fukutomi, W. Chen, H. Imai, M. Fujisawa, K. Okumiya, G. W. Taylor, T. Ansai, H. Miyazaki, K. Matsubayashi

JOURNAL OF PERIODONTAL RESEARCH 51 ( 5 ) 681 - 688 2016.10

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DOI： 10.1111/jre.12348

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Cystatin C-based estimated glomerular filtration rate and periodontitis

Masanori Iwasaki, George W. Taylor, Misuzu Sato, Kazutoshi Nakamura, Akihiro Yoshihara, Hideo Miyazaki

GERODONTOLOGY 33 ( 3 ) 328 - 334 2016.9

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DOI： 10.1111/ger.12159

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Bidirectional relationship between renal function and periodontal disease in older Japanese women

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

JOURNAL OF CLINICAL PERIODONTOLOGY 43 ( 9 ) 720 - 726 2016.9

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DOI： 10.1111/jcpe.12576

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Maximum bite force at age 70 years predicts all-cause mortality during the following 13 years in Japanese men Reviewed

M. Iwasaki, A. Yoshihara, N. Sato, M. Sato, G. W. Taylor, T. Ansai, T. Ono, H. Miyazaki

Journal of Oral Rehabilitation 43 ( 8 ) 565 - 574 2016.8

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DOI： 10.1111/joor.12401

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小学校における昼休みを活用した歯みがき指導の効果

高橋明恵, 葭原明弘, 中島俊一, 諏訪間加奈, 宮崎晶子

日本歯科衛生学会雑誌 11 ( 1 ) 90 - 90 2016.8

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A century of trends in adult human height Reviewed

James Bentham, Mariachiara Di Cesare, Gretchen A. Stevens, Bin Zhou, Honor Bixby, Melanie Cowan, Lea Fortunato, James E. Bennett, Goodarz Danaei, Kaveh Hajifathalian, Yuan Lu, Leanne M. Riley, Avula Laxmaiah, Vasilis Kontis, Christopher J. Paciorek, Elio Riboli, Majid Ezzati, Ziad A. Abdeen, Zargar Abdul Hamid, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Robert Adams, Wichai Aekplakorn, Carlos A. Aguilar-Salinas, Charles Agyemang, Alireza Ahmadvand, Wolfgang Ahrens, Hazzaa M. Al-Hazzaa, Amani Rashed Al-Othman, Rajaa Al Raddadi, Mohamed M. Ali, Ala'a Alkerwi, Mar Alvarez-Pedrerol, Eman Aly, Philippe Amouyel, Antoinette Amuzu, Lars Bo Andersen, Sigmund A. Anderssen, Ranjit Mohan Anjana, Hajer Aounallah-Skhiri, Inger Ariansen, Tahir Aris, Nimmathota Arlappa, Dominique Arveiler, Felix K. Assah, Maria Avdicova, Fereidoun Azizi, Bontha V. Babu, Suhad Bahijri, Nagalla Balakrishna, Piotr Bandosz, Jose R. Banegas, Carlo M. Barbagallo, Alberto Barcelo, Amina Barkat, Mauro V. Barros, Iqbal Bata, Anwar M. Batieha, Rosangela L. Batista, Louise A. Baur, Robert Beaglehole, Habiba Ben Romdhane, Mikhail Benet, James E. Bennett, Antonio Bernabe-Ortiz, Gailute Bernotine, Heloisa Bettiol, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K. Bhargava, Zaid Bhatti, Zulfiqar A. Bhutta, Hongsheng Bi, Yufang Bi, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Bjorkelund, Anneke Blokstra, Simona Bo, Martin Bobak, Lynne M. Boddy, Bernhard O. Boehm, Heiner Boeing, Carlos P. Boissonnet, Vanina Bongard, Pascal Bovet, Lutgart Braeckman, Marjolijn C. E. Bragt, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Graziella Bruno, H. B(as) Bueno-de-Mesquita, Anna Bugge, Con Burns, Antonio Cabrera de Leon, Joseph Cacciottolo, Tilema Cama, Christine Cameron, Jose Camolas, Gunay Can, Ana Paula C. Candido, Vincenzo Capuano, Viviane C. Cardoso, Axel C. Carlsson, Maria J. Carvalho, Felipe F. Casanueva, Juan-Pablo Casas, Carmelo A. Caserta, Snehalatha Chamukuttan, Angelique W. Chan, Queenie Chan, Himanshu K. Chaturvedi, Nishi Chaturvedi, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Angela Chetrit, Arnaud Chiolero, Shu-Ti Chiou, Adela Chirita-Emandi, Belong Cho, Yumi Cho, Kaare Christensen, Jerzy Chudek, Renata Cifkova, Frank Claessens, Els Clays, Hans Concin, Cyrus Cooper, Rachel Cooper, Tara C. Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L. Craig, Ana B. Crujeiras, Graziella D'Arrigo, Eleonora d'Orsi, Jean Dallongeville, Albertino Damasceno, Camilla T. Damsgaard, Goodarz Danaei, Rachel Dankner, Luc Dauchet, Guy De Backer, Dirk De Bacque, Giovanni de Gaetano, Stefaan De Hanauw, Delphine De Smedt, Mohan Deepa, Alexander D. Deev, Abbas Dehghan, Helene Delisle, Francis Delpeuch, Valerie Deschamps, Klodian Dhana, Augusto F. Di Castelnuovo, Juvenal Soares Dias-da-Costa, Alejandro Diaz, Shirin Djalalinia, Ha T. P. Do, Annette J. Dobson, Chiara Donfrancesco, Silvana P. Donoso, Angela Doering, Kouamelan Doua, Wojciech Drygas, Vilnis Dzerve, Eruke E. Egbagbe, Robert Eggertsen, Ulf Ekelund, Jalila El Ati, Paul Elliott, Reina Engle-Stone, Rajiv T. Erasmus, Cihangir Erem, Loise Eriksen, Jorge Escobedo-de la Pena, Alun Evans, David Faeh, Caroline H. Fall, Farshad Farzadfar, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernandez-Berges, Daniel Ferrante, Marika Ferrari, Catterina Ferreccio, Jean Ferrieres, Joseph D. Finn, Krista Fischer, Eric Monterubio Flores, Bernhard Foeger, Leng Huat Foo, Ann-Sofie Forslund, Maria Forsner, Stephen P. Fortmann, Heba M. Francis, Damian K. Francis, Maria do Carmo Franco, Oscar H. Franco, Guillermo Frontera, Flavio D. Fuchs, Sandra C. Fuchs, Yuki Fujita, Takuro Furusawa, Takuro Furusawa, Zbigniew Gaciong, Mihai Gafencu, Dickman Gareta, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Johanna M. Geleijnse, Anoosheh Ghasemian, Simona Giampaoli, Francesco Gianfagna, Jonathan Giovannelli, Aleksander Giwercman, Rebecca A. Goldsmith, Helen Goncalves, Marcela Gonzalez Gross, Juan P. Gonzalez Rivas, Mariano Bonet Gorbea, Frederic Gottrand, Sidsel Graff-Iversen, Dusan Grafnetter, Aneta Grajda, Maria G. Grammatikopoulou, Ronald D. Gregor, Tomasz Grodzicki, Anders Grontved, Grabriella Gruden, Vera Grujic, Dongfeng Gu, Emanuela Gualdi-Russo, Ong Peng Guan, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L. Guimaraes, Martin C. Gulliford, Johanna Gunnlaugsdottir, Marc Gunter, Xiuhua Guo, Yin Guo, Prakash C. Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Jytte Halkjaer, Ian R. Hambleton, Rebecca Hardy, Rachakulla Hari Kumar, Jun Hata, Alison J. Hayes, Jiang He, Marleen Ekisabeth Hendriks, Leticia Hernandez Cadena, Sauli Herrala, Ramin Heshmat, Ilpo Tapani Hihtaniemi, Sai Yin Ho, Suzanne C. Ho, Michael Hobbs, Albert Hofman, Claudi M. Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, Abdullatif Husseini, Chinh Nguyen Huu, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G. Iannone, Mohsen M. Ibrahim, Nayu Ikeda, M. Arfan Ikram, Vilma E. Irazola, Muhammad Islam, Vanja Ivkovic, Masanori Iwasaki, Rod T. Jackson, Jeremy M. Jacobs, Tazeen Jafar, Kazi M. Jamil, Konrad Jamrozik, Imre Janszky, Grazyna Jasienska, Bojan Jelakovic, Chao Qiang Jiang, Michel Joffres, Mattias Johansson, Jost B. Jonas, Torben Jorgensen, Pradeep Joshi, Anne Juolevi, Gregor Jurak, Vesno Juresa, Rudolf Kaaks, Anthony Kafatos, Ofra Kalter-Leibovici, Efthymios Kapantais, Amir Kasaeian, Joanne Katz, Prabhdeep Kaur, Maryam Kavousi, Ulrich Keil, Lital Keinan Boker, Sirkka Keinanen-Kiukaanniemi, Roya Kelishadi, Han C. G. Kemper, Andre P. Kengne, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Young-Ho Khang, Kay-Tee H. Khaw, Ilse M. S. L. Khouw, Stefan Kiechl, Japhet Killewo, Jeongseon Kim, Jeannette Klimont, Jurate Klumbiene, Bhawesh Koirala, Elin Kolle, Patrick Kolsteren, Paul Korrovits, Seppo Koskinen, Katsuyasu Kouda, Slawomir Koziel, Wolfgang Kratzer, Steinar Krokstad, Daan Kromhout, Herculina S. Kruger, Ruzena Kubinova, Urho M. Kujala, Krzysztof Kula, Zbigniew Kulaga, R. Krishna Kumar, Pawel Kurjata, Yadlapalli S. Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Fatima Zahra Laamiri, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Bagher Larijani, Lars E. Laugsand, Avula Laxmaiah, Khanh Le Nguyen Bao, Tuyen D Le, Catherine Leclercq, Jeannette Lee, Jeonghee Lee, Terho Lehtimaki, Rampal Lekhraj, Luz M. Leon-Munoz, Yanping Li, Christa L. Lilly, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Jing Liu, Roberto Lorbeer, Paulo A. Lotufo, Jose Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Guansheng Ma, Jun Ma, George L. L. Machado-Coelho, Suka Machi, Stefania Maggi, Dianna J. Magliano, Bernard Maire, Marcia Makdisse, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Yannis Manios, Jim I. Mann, Enzo Manzato, Paula Margozzini, Oonagh Markey, Pedro Marques-Vidal, Jaume Marrugat, Yves Martin-Prevel, Reynaldo Martorell, Shariq R. Masoodi, Ellisiv B. Mathiesen, Tandi E. Matsha, Artur Mazur, Jean Claude N. Mbanya, Shelly R. McFarlane, Stephen T. McGarvey, Martin McKee, Stela McLachlan, Rachael M. McLean, Breige A. McNulty, Safiah Md Yusof, Sounnia Mediene-Benchekor, Aline Meirhaeghe, Christa Meisinger, Ana Maria B. Menezes, Gert B. M. Mensink, Indrapal I. Meshram, Andres Metspalu, Jie Mi, Kim F. Michaelsen, Kairit Mikkel, Jody C. Miller, Juan Francisco Miquel, J. Jaime Miranda, Marjeta Misigoj-Durakovic, Mostafa K. Mohamed, Kazem Mohammad, Noushin Mohammadifard, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Drude Molbo, Niels C. Moller, Denes Molnar, Charles K. Mondo, Eric A. Monterrubio, Kotsedi Daniel K. Monyeki, Leila B. Moreira, Alain Morejon, Luis A. Moreno, Karen Morgan, Erik Lykke Mortensen, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Thet Thet Mu, Maria Lorenza Muiesan, Martina Mueller-Nurasyid, Neil Murphy, Jaakko Mursu, Elaine M. Murtagh, Kamarul Imran Musa, Vera Musil, Gabriele Nagel, Harunobu Nakamura, Jana Namesna, Ei Ei K. Nang, Vinay B. Nangia, Martin Nankap, Sameer Narake, Eva Maria Navarrete-Munoz, William A. Neal, Ilona Nenko, Martin Neovius, Flavio Nervi, Hannelore K. Neuhauser, Nguyen D. Nguyen, Quang Ngoc Nguyen, Ramfis E. Nieto-Martinez, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Teresa Norat, Davide Noto, Mohannad Al Nsour, Dermot O'Reilly, Kyungwon Oh, Iman H. Olayan, Maria Teresa Anselmo Olinto, Maciej Oltarzewski, Mohd A. Omar, Altan Onat, Pedro Ordunez, Ana P. Ortiz, Merete Osler, Clive Osmond, Sergej M. Ostojic, Johanna A. Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Elena Pahomova, Andrzej Pajak, Domenico Palli, Alberto Palloni, Luigi Palmieri, Songhomitra Panda-Jonas, Francesco Panza, Winsome R. Parnell, Mahboubeh Parsaeian, Ivan Pecin, Mangesh S. Pednekar, Petra H. Peeters, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Cynthia M. Perez, Annette Peters, Janina Petkeviciene, Niloofar Peykari, Son Thai Pham, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Francesco Pistelli, Freda Pitakaka, Aleksandra Piwonska, Pedro Plans-Rubio, Bee Koon Poh, Miquel Porta, Marileen L. P. Portegies, Dimitrios Poulimeneas, Rajendra Pradeepa, Mathur Prashant, Jacqueline F. Price, Maria Puiu, Margus Punab, Radwan F. Qasrawi, Mostafa Qorbani, Tran Quoc Bao, Ivana Radic, Ricardas Radisauskas, Mahmudur Rahman, Olli Raitakari, Manu Raj, Sudha Ramachandra Rao, Ambady Ramachandran, Jacqueline Ramke, Rafel Ramos, Sanjay Rampal, Finn Rasmussen, Josep Redon, Paul Ferdinand M. Reganit, Robespierre Ribeiro, Elio Riboli, Fernando Rigo, Tobias F. Rinke de Wit, Raphael M. Ritti-Dias, Juan A. Rivera, Sian M. Robinson, Cynthia Robitaille, Fernando Rodri-guez-Artalejo, Maria del Cristo Rodriguez-Perez, Laura A. Rodriguez-Villamizar, Rosalba Rojas-Martinez, Nipa Rojroongwasinkul, Dora Romaguera, Kimmo Ronkainen, Annika Rosengren, Ian Rouse, Adolfo Rubinstein, Frank J. Ruhli, Ornelas Rui, Blanca Sandra Ruiz-Betancourt, Andrea R. V. Russo Horimoto, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S. Sachdev, Olfa Saidi, Benoit Salanave, Eduardo Salazar Martinez, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Jose Sanchez-Abanto, Sandjaja, Susana Sans, Diana A. Santos, Osvaldo Santos, Renata Nunes dos Santos, Rute Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Savvas C. Savva, Marcia Scazufca, Angelika Schaffrath Rosario, Herman Schargrodsky, Anja Schienkiewitz, Ida Maria Schmidt, Ione J. Schneider, Constance Schultsz, Aletta E. Schutte, Aye Aye Sein, Abhijit Sen, Idowu O. Senbanjo, Sadaf G. Sepanlou, Svetlana A. Shalnova, Sanjib K. Sharma, Jonathan E. Shaw, Kenji Shibuya, Dong Wook Shin, Youchan Shin, Rahman Shiri, Rosalynn Siantar, Abla M. Sibai, Antonio M. Silva, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjostrom, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Margaret C. Smith, Marieke B. Snijder, Hung-Kwan So, Eugene Sobngwi, Stefan Soderberg, Moesijanti Y. E. Soekatri, Vincenzo Solfrizzi, Emily Sonestedt, Yi Song, Thorkild I. A. Sorensen, Maroje Soric, Charles Sossa Jerome, Aicha Soumare, Jan A. Staessen, Gregor Starc, Maria G. Stathopoulou, Kaspar Staub, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, George S. Stergiou, Jochanan Stessman, Jutta Stieber, Doris Stoeckl, Tanja Stocks, Jakub Stokwiszewski, Gareth Stratton, Karien Stronks, Maria Wany Strufaldi, Chien-An Sun, Johan Sundstroem, Yn-Tz Sung, Jordi Sunyer, Paibul Suriyawongpaisal, Boyd A. Swinburn, Rody G. Sy, Lucjan Szponar, E. Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Line Tang, Xun Tang, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Jakob Tarp, Carolina B. Tarqui-Mamani, Anne Taylor, Felicite Tchibindat, Holger Theobald, Lutgarde Thijs, Betina H. Thuesen, Anne Tjonneland, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Roman Topor-Madry, Maties Torrent, Stefania Toselli, Pierre Traissac, Antonia Trichopoulou, Dimitrios Trichopoulos, Oanh T. H. Trinh, Atul Trivedi, Lechaba Tshepo, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L. Turley, Per Tynelius, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Flora A. M. Ukoli, Hanno Ulmer, Belgin Unal, Hannu M. T. Uusitalo, Gonzalo Valdivia, Susana Vale, Damaskini Valvi, Yvonne T. van der Schouw, Koen Van Herck, Hoang Van Minh, Lenie van Rossem, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Lars Vatten, Tomas Vega, Gustavo Velasquez-Melendez, Giovanni Veronesi, W. M. Monique Verschuren, Roosmarijn Verstraeten, Cesar G. Victora, Giovanni Viegi, Lucie Viet, Eira Viikari-Juntura, Paolo Vineis, Jesus Vioque, Jyrki K. Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Peter Vollenweider, Sari Voutilainen, Ana Vrdoljak, Martine Vrijheid, Alisha N. Wade, Aline Wagner, Janette Walton, Wan Nazaimoon Wan Mohamud, Ming-Dong Wang, Qian Wang, Ya Xing Wang, S. Goya Wannamethee, Nicholas Wareham, Deepa Weerasekera, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Wiecek, Alet H. Wijga, Rainford J. Wilks, Johann Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Jyh Eiin Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C. Wu, Jianfeng Wu, Shou Ling Wu, Haiquan Xu, Liang Xu, Uruwan Yamborisut, Weili Yan, Xiaoguang Yang, Nazan Yardim, Xingwang Ye, Panayiotis K. Yiallouros, Akihiro Yoshihara, Qi Sheng You, Novie O. Younger-Coleman, Ahmad F. Yusoff, Ahmad A. Zainuddin, Sabina Zambon, Tomasz Zdrojewski, Yi Zeng, Dong Zhao, Wenhua Zhao, Yingfeng Zheng, Maigeng Zhou, Dan Zhu, Esther Zimmermann, Julio Zuniga Cisneros

ELIFE 5 2016.7

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TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 239 ( 2 ) 95 - 101 2016.6

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GERODONTOLOGY 33 ( 2 ) 193 - 200 2016.6

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Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants Reviewed

Bin Zhou, Yuan Lu, Kaveh Hajifathalian, James Bentham, Mariachiara Di Cesare, Goodarz Danaei, Honor Bixby, Melanie J. Cowan, Mohammed K. Ali, Cristina Taddei, Wei-Cheng Lo, Barbara Reis-Santos, Gretchen A. Stevens, Leanne M. Riley, J. Jaime Miranda, Peter Bjerregaard, Juan A. Rivera, Heba M. Fouad, Guansheng Ma, Jean Claude N. Mbanya, Stephen T. McGarvey, Viswanathan Mohan, Altan Onat, Ambady Ramachandran, Habiba Ben Romdhane, Christopher J. Paciorek, James E. Bennett, Majid Ezzati, Ziad A. Abdeen, Khalid Abdul Kadir, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Robert Adams, Wichai Aekplakorn, Carlos A. Aguilar-Salinas, Charles Agyemang, Alireza Ahmadvand, Amani Rashed Al-Othman, Ala'a Alkerwi, Philippe Amouyel, Antoinette Amuzu, Lars Bo Andersen, Sigmund A. Anderssen, Ranjit Mohan Anjana, Hajer Aounallah-Skhiri, Tahir Aris, Nimmathota Arlappa, Dominique Arveiler, Felix K. Assah, Maria Avdicova, Fereidoun Azizi, Nagalla Balakrishna, Piotr Bandosz, Carlo M. Barbagallo, Alberto Barcelo, Anwar M. Batieha, Louise A. Baur, Habiba Ben Romdhane, Mikhail Benet, Antonio Bernabe-Ortiz, Sumit Bharadwaj, Santosh K. Bhargava, Yufang Bi, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Bjorkelund, Anneke Blokstra, Simona Bo, Bernhard O. Boehm, Carlos P. Boissonnet, Pascal Bovet, Imperia Brajkovich, Juergen Breckenkamp, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Graziella Bruno, Anna Bugge, Antonio Cabrera de Leon, Gunay Can, Ana Paula C. Candido, Vincenzo Capuano, Axel C. Carlsson, Maria J. Carvalho, Felipe F. Casanueva, Juan-Pablo Casas, Carmelo A. Caserta, Katia Castetbon, Snehalatha Chamukuttan, Nishi Chaturvedi, Chien-Jen Chen, Fangfang Chen, Shuohua Chen, Ching-Yu Cheng, Angela Chetrit, Shu-Ti Chiou, Yumi Cho, Jerzy Chudek, Renata Cifkova, Frank Claessens, Hans Concin, Cyrus Cooper, Rachel Cooper, Simona Costanzo, Dominique Cottel, Chris Cowell, Ana B. Crujeiras, Graziella D'Arrigo, Jean Dallongeville, Rachel Dankner, Luc Dauchet, Giovanni de Gaetano, Stefaan De Henauw, Mohan Deepa, Abbas Dehghan, Valerie Deschamps, Klodian Dhana, Augusto F. Di Castelnuovo, Shirin Djalalinia, Kouamelan Doua, Wojciech Drygas, Yong Du, Vilnis Dzerve, Eruke E. Egbagbe, Robert Eggertsen, Jalila El Ati, Roberto Elosua, Rajiv T. Erasmus, Cihangir Erem, Gul Ergor, Louise Eriksen, Jorge Escobedo-de la Pena, Caroline H. Fall, Farshad Farzadfar, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernandez-Berges, Marika Ferrari, Catterina Ferreccio, Edith J. M. Feskens, Joseph D. Finn, Bernhard Foeger, Leng Huat Foo, Ann-Sofie Forslund, Heba M. Fouad, Damian K. Francis, Maria do Carmo Franco, Oscar H. Franco, Guillermo Frontera, Takuro Furusawa, Zbigniew Gaciong, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Johanna M. Geleijnse, Anoosheh Ghasemian, Anup Ghimire, Simona Giampaoli, Francesco Gianfagna, Jonathan Giovannelli, Aleksander Giwercman, Marcela Gonzalez Gross, Juan P. Gonzalez Rivas, Mariano Bonet Gorbea, Frederic Gottrand, Dusan Grafnetter, Tomasz Grodzicki, Anders Grontved, Grabriella Gruden, Dongfeng Gu, Ong Peng Guan, Ramiro Guerrero, Idris Guessous, Andre L. Guimaraes, Laura Gutierrez, Ian R. Hambleton, Rebecca Hardy, Rachakulla Hari Kumar, Jun Hata, Christin Heidemann, Sauli Herrala, Ilpo Tapani Hihtaniemi, Sai Yin Ho, Suzanne C. Ho, Albert Hofman, Claudia M. Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Maung Maung Than Htike, Yang Hu, Abdullatif S. Hussieni, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G. Iannone, M. Mohsen Ibrahim, Nayu Ikeda, M. Arfan Ikram, Vilma E. Irazola, Muhammad Islam, Masanori Iwasaki, Jeremy M. Jacobs, Tazeen Jafar, Kazi M. Jamil, Grazyna Jasienska, Chao Qiang Jiang, Jost B. Jonas, Pradeep Joshi, Anthony Kafatos, Ofra Kalter-Leibovici, Amir Kasaeian, Joanne Katz, Prabhdeep Kaur, Maryam Kavousi, Roya Kelishadi, Andre P. Kengne, Mathilde Kersting, Yousef Saleh Khader, Davood Khalili, Young-Ho Khang, Stefan Kiechl, Jeongseon Kim, Patrick Kolsteren, Wolfgang Kratzer, Daan Kromhout, Urho M. Kujala, Krzysztof Kula, Catherine Kyobutungi, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Avula Laxmaiah, Catherine Leclercq, Jeannette Lee, Jeonghee Lee, Terho Lehtimaki, Rampal Lekhraj, Luz M. Leon-Munoz, Yanping Li, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Lauren Lissner, Roberto Lorbeer, Jose Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Per Lytsy, Guansheng Ma, George L. L. Machado-Coelho, Suka Machi, Stefania Maggi, Dianna J. Magliano, Marcia Makdisse, Kodavanti Mallikharjuna Rao, Yannis Manios, Enzo Manzato, Paula Margozzini, Pedro Marques-Vidal, Reynaldo Martorell, Shariq R. Masoodi, Ellisiv B. Mathiesen, Tandi E. Matsha, Jean Claude N. Mbanya, Shelly R. McFarlane, Stephen T. McGarvey, Stela McLachlan, Breige A. McNulty, Sounnia Mediene-Benchekor, Aline Meirhaeghe, Ana Maria B. Menezes, Shahin Merat, Indrapal I. Meshram, Jie Mi, Juan Francisco Miquel, J. Jaime Miranda, Mostafa K. Mohamed, Kazem Mohammad, Noushin Mohammadifard, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Niels C. Moller, Denes Molnar, Charles K. Mondo, Alain Morejon, Luis A. Moreno, Karen Morgan, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Jorge Motta, Thet Thet Mu, Maria Lorenza Muiesan, Martina Mueller-Nurasyid, Jaakko Mursu, Gabriele Nagel, Jana Namesna, Ei Ei K. Nang, Vinay B. Nangia, Eva Maria Navarrete-Munoz, Ndeye Coumba Ndiaye, Ilona Nenko, Flavio Nervi, Nguyen D. Nguyen, Quang Ngoc Nguyen, Ramfi S. E. Nieto-Martinez, Guang Ning, Toshiharu Ninomiya, Marianna Noale, Davide Noto, Mohannad Al Nsour, Angelica M. Ochoa-Aviles, Kyungwon Oh, Altan Onat, Pedro Ordunez, Clive Osmond, Johanna A. Otero, Ellis Owusu-Dabo, Elena Pahomova, Luigi Palmieri, Songhomitra Panda-Jonas, Francesco Panza, Mahboubeh Parsaeian, Sergio Viana Peixoto, Markku Peltonen, Annette Peters, Niloofar Peykari, Son Thai Pham, Aida Pilav, Freda Pitakaka, Aleksandra Piwonska, Jerzy Piwonski, Pedro Plans-Rubio, Miquel Porta, Marileen L. P. Portegies, Hossein Poustchi, Rajendra Pradeepa, Jacqueline F. Price, Margus Punab, Radwan F. Qasrawi, Mostafa Qorbani, Ricardas Radisauskas, Mahmudur Rahman, Olli Raitakari, Sudha Ramachandra Rao, Ambady Ramachandran, Jacqueline Ramke, Rafel Ramos, Sanjay Rampal, Wolfgang Rathmann, Josep Redon, Paul Ferdinand M. Reganit, Fernando Rigo, Sian M. Robinson, Cynthia Robitaille, Fernando Rodriguez-Artalejo, Maria del Cristo Rodriguez-Perez, Laura A. Rodriguez-Villamizar, Rosalba Rojas-Martinez, Kimmo Ronkainen, Annika Rosengren, Adolfo Rubinstein, Ornelas Rui, Blanca Sandra Ruiz-Betancourt, Andrea R. V. Russo Horimoto, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S. Sachdev, Olfa Saidi, Sibel Sakarya, Benoit Salanave, Jukka T. Salonen, Massimo Salvetti, Jose Sanchez-Abanto, Diana Santos, Renata Nunes dos Santos, Rute Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Marcia Scazufca, Herman Schargrodsky, Christa Scheidt-Nave, Aye Aye Sein, Sanjb K. Sharma, Jonathan E. Shaw, Kenji Shibuya, Youchan Shin, Rahman Shiri, Rosalynn Siantar, Abla M. Sibai, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjostrom, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Marieke B. Snijder, Hung-Kwan So, Eugene Sobngwi, Stefan Soderberg, Vincenzo Solfrizzi, Emily Sonestedt, Aicha Soumare, Jan A. Staessen, Maria G. Stathopoulou, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, Jochanan Stessman, Doris Stoeckl, Jakub Stokwiszewski, Karien Stronks, Maria Wany Strufaldi, Chien-An Sun, Johan Sundstrom, Yn-Tz Sung, Paibul Suriyawongpaisal, Rody G. Sy, E. Shyong Tai, Abdonas Tamosiunas, Line Tang, Mohammed Tarawneh, Carolina B. Tarqui-Mamani, Anne Taylor, Holger Theobald, Lutgarde Thijs, Betina H. Thuesen, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Maties Torrent, Pierre Traissac, Oanh T. H. Trinh, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Maria L. Turley, Christophe Tzourio, Peter Ueda, Flora A. M. Ukoli, Hanno Ulmer, Hannu M. T. Uusitalo, Gonzalo Valdivia, Damaskini Valvi, Lenie van Rossem, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Tomas Vega, Gustavo Velasquez-Melendez, Giovanni Veronesi, W. M. Monique Verschuren, Roosmarijn Verstraeten, Lucie Viet, Jesus Vioque, Jyrki K. Virtanen, Bharathi Viswanathan, Peter Vollenweider, Sari Voutilainen, Martine Vrijheid, Alisha N. Wade, Aline Wagner, Janette Walton, Wan Nazaimoon Wan Mohamud, Feng Wang, Ming-Dong Wang, Qian Wang, Ya Xing Wang, S. Goya Wannamethee, Deepa Weerasekera, Peter H. Whincup, Kurt Widhalm, Alet H. Wijga, Rainford J. Wilks, Johann Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C. Wu, Shou Ling Wu, Haiquan Xu, Weili Yan, Xiaoguang Yang, Xingwang Ye, Akihiro Yoshihara, Novie O. Younger-Coleman, Sabina Zambon, Abdul Hamid Zargar, Tomasz Zdrojewski, Wenhua Zhao, Yingfeng Zheng, Julio Zuniga Cisneros

LANCET 387 ( 10027 ) 1513 - 1530 2016.4

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Hyposalivation and dietary nutrient intake among community-based older Japanese

Masanori Iwasaki, Akihiro Yoshihara, Kayoko Ito, Misuzu Sato, Kumiko Minagawa, Kanako Muramatsu, Reiko Watanabe, Michael C. Manz, Toshihiro Ansai, Hideo Miyazaki

GERIATRICS & GERONTOLOGY INTERNATIONAL 16 ( 4 ) 500 - 507 2016.4

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DOI： 10.1111/ggi.12500

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知的障害者施設入所者における在所期間と口腔内状態および口腔に関連する支援状態の関連 Reviewed

石川裕子, 米澤大輔, 葭原明弘, 齊藤一誠, 早崎治明

口腔衛生学会雑誌 66 ( 3 ) 338 - 343 2016.4

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DOI： 10.5834/jdh.66.3_338

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J00440&link_issn=&doc_id=20160524380005&doc_link_id=%2Fdk1dehea%2F2016%2F006603%2F005%2F0338-0343%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2016%2F006603%2F005%2F0338-0343%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants Reviewed

Mariachiara Di Cesare, James Bentham, Gretchen A. Stevens, Bin Zhou, Goodarz Danaei, Yuan Lu, Honor Bixby, Melanie J. Cowan, Leanne M. Riley, Kaveh Hajifathalian, Lea Fortunato, Cristina Taddei, James E. Bennett, Nayu Ikeda, Young-Ho Khang, Catherine Kyobutungi, Avula Laxmaiah, Yanping Li, Hsien-Ho Lin, J. Jaime Miranda, Aya Mostafa, Maria L. Turley, Christopher J. Paciorek, Marc Gunter, Majid Ezzati, Ziad A. Abdeen, Zargar Abdul Hamid, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Robert Adams, Wichai Aekplakorn, Carlos A. Aguilar-Salinas, Alireza Ahmadvand, Wolfgang Ahrens, Mohamed M. Ali, Ala'a Alkerwi, Mar Alvarez-Pedrerol, Eman Aly, Philippe Amouyel, Antoinette Amuzu, Lars Bo Andersen, Sigmund A. Anderssen, Dolores S. Andrade, Ranjit Mohan Anjana, Hajer Aounallah-Skhiri, Inger Ariansen, Tahir Aris, Nimmathota Arlappa, Dominique Arveiler, Felix K. Assah, Maria Avdicova, Fereidoun Azizi, Bontha V. Babu, Nagalla Balakrishna, Piotr Bandosz, Jose R. Banegas, Carlo M. Barbagallo, Alberto Barcelo, Amina Barkat, Mauro V. Barros, Iqbal Bata, Anwar M. Batieha, Rosangela L. Batista, Louise A. Baur, Robert Beaglehole, Habiba Ben Romdhane, Mikhail Benet, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloisa Bettiol, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K. Bhargava, Zaid Bhatti, Zulfiqar A. Bhutta, HongSheng Bi, Yufang Bi, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Bjorkelund, Margaret Blake, Anneke Blokstra, Simona Bo, Martin Bobak, Lynne M. Boddy, Bernhard O. Boehm, Heiner Boeing, Carlos P. Boissonnet, Vanina Bongard, Pascal Bovet, Lutgart Braeckman, Marjolijn C. E. Bragt, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Graziella Bruno, H. B(as) Bueno-de-Mesquita, Anna Bugge, Con Burns, Antonio Cabrera de Leon, Joseph Cacciottolo, Tilema Cama, Christine Cameron, Jose Camolas, Gunay Can, Ana Paula C. Candido, Vincenzo Capuano, Viviane C. Cardoso, Maria J. Carvalho, Felipe F. Casanueva, Juan-Pablo Casas, Carmelo A. Caserta, Katia Castetbon, Snehalatha Chamukuttan, Angelique W. Chan, Queenie Chan, Himanshu K. Chaturvedi, Nishi Chaturvedi, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Angela Chetrit, Arnaud Chiolero, Shu-Ti Chiou, Adela Chirita-Emandi, Yumi Cho, Kaare Christensen, Jerzy Chudek, Renata Cifkova, Frank Claessens, Els Clays, Hans Concin, Cyrus Cooper, Rachel Cooper, Tara C. Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L. Craig, Ana B. Crujeiras, Graziella D'Arrigo, Eleonora d'Orsi, Jean Dallongeville, Albertino Damasceno, Camilla T. Damsgaard, Goodarz Danaei, Rachel Dankner, Luc Dauchet, Guy De Backer, Dirk De Bacquer, Giovanni de Gaetano, Stefaan De Henauw, Delphine De Smedt, Mohan Deepa, Alexander D. Deev, Abbas Dehghan, Helene Delisle, Francis Delpeuch, Klodian Dhana, Augusto F. Di Castelnuovo, Juvenal Soares Dias-da-Costa, Alejandro Diaz, Shirin Djalalinia, Ha T. P. Do, Annette J. Dobson, Chiara Donfrancesco, Angela Doering, Kouamelan Doua, Wojciech Drygas, Eruke E. Egbagbe, Robert Eggertsen, Ulf Ekelund, Jalila El Ati, Paul Elliott, Reina Engle-Stone, Rajiv T. Erasmus, Cihangir Erem, Louise Eriksen, Jorge Escobedo-de la Pena, Alun Evans, David Faeh, Caroline H. Fall, Farshad Farzadfar, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernandez-Berges, Daniel Ferrante, Marika Ferrari, Catterina Ferreccio, Jean Ferrieres, Joseph D. Finn, Krista Fischer, Eric Monterubio Flores, Bernhard Foeger, Leng Huat Foo, Ann-Sofie Forslund, Stephen P. Fortmann, Heba M. Fouad, Damian K. Francis, Maria do Carmo Franco, Oscar H. Franco, Guillermo Frontera, Flavio D. Fuchs, Sandra C. Fuchs, Yuki Fujita, Takuro Furusawa, Zbigniew Gaciong, Mihai Gafencu, Dickman Gareta, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Johanna M. Geleijnse, Anoosheh Ghasemian, Simona Giampaoli, Francesco Gianfagna, Jonathan Giovannelli, Aleksander Giwercman, Rebecca A. Goldsmith, Marcela Gonzalez Gross, Juan P. Gonzalez Rivas, Mariano Bonet Gorbea, Frederic Gottrand, Sidsel Graff -Iversen, Dusan Grafnetter, Aneta Grajda, Maria G. Grammatikopoulou, Ronald D. Gregor, Tomasz Grodzicki, Anders Grontved, Grabriella Gruden, Vera Grujic, Dongfeng Gu, Ong Peng Guan, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L. Guimaraes, Martin C. Gulliford, Johanna Gunnlaugsdottir, Marc Gunter, Xiu H. Guo, Yin Guo, Prakash C. Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Jytte Halkjaer, Rebecca Hardy, Rachakulla Hari Kumar, Alison J. Hayes, Jiang He, Marleen Elisabeth Hendriks, Leticia Hernandez Cadena, Ramin Heshmat, Ilpo Tapani Hihtaniemi, Sai Yin Ho, Suzanne C. Ho, Michael Hobbs, Albert Hofman, Claudia M. Hormiga, Bernardo L. Horta, Leila Houti, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, Abdullatif S. Hussieni, Chinh Nguyen Huu, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G. Iannone, M. Mohsen Ibrahim, Nayu Ikeda, M. Arfan Ikram, Vilma E. Irazola, Muhammad Islam, Masanori Iwasaki, Rod T. Jackson, Jeremy M. Jacobs, Tazeen Jafar, Kazi M. Jamil, Konrad Jamrozik, Grazyna Jasienska, Chao Qiang Jiang, Michel Joffres, Mattias Johansson, Jost B. Jonas, Torben Jorgensen, Pradeep Joshi, Anne Juolevi, Gregor Jurak, Vesna Juresa, Rudolf Kaaks, Anthony Kafatos, Ofra Kalter-Leibovici, Efthymios Kapantais, Amir Kasaeian, Joanne Katz, Prabhdeep Kaur, Maryam Kavousi, Ulrich Keil, Lital Keinan Boker, Roya Kelishadi, Han H. C. G. Kemper, Andre P. Kengne, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Young-Ho Khang, Kay-Tee H. Khaw, Ilse M. S. L. Khouw, Stefan Kiechl, Japhet Killewo, Jeongseon Kim, Yutaka Kiyohara, Jeannette Klimont, Elin Kolle, Patrick Kolsteren, Paul Korrovits, Seppo Koskinen, Katsuyasu Kouda, Slawomir Koziel, Wolfgang Kratzer, Steinar Krokstad, Daan Kromhout, Herculina S. Kruger, Krzysztof Kula, Zbigniew Kulaga, R. Krishna Kumar, Yadlapalli S. Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Fatima Zahra Laamiri, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Lars E. Laugsand, Avula Laxmaiah, Khanh Le Nguyen Bao, Tuyen D. Le, Catherine Leclercq, Jeannette Lee, Jeonghee Lee, Terho Lehtimaki, Rampal Lekhraj, Luz M. Leon-Munoz, Yanping Li, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Jing Liu, Roberto Lorbeer, Paulo A. Lotufo, Jose Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Per Lytsy, Guansheng Ma, Suka Machi, Stefania Maggi, Dianna J. Magliano, Marcia Makdisse, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Yannis Manios, Jim I. Mann, Enzo Manzato, Paula Margozzini, Oonagh Markey, Pedro Marques-Vidal, Jaume Marrugat, Yves Martin-Prevel, Reynaldo Martorell, Shariq R. Masoodi, Tandi E. Matsha, Artur Mazur, Jean Claude N. Mbanya, Shelly R. McFarlane, Stephen T. McGarvey, Martin McKee, Stela McLachlan, Rachael M. McLean, Breige A. McNulty, Safiah Md Yusof, Sounnia Mediene-Benchekor, Aline Meirhaeghe, Christa Meisinger, Larissa L. Mendes, Ana Maria B. Menezes, Gert B. M. Mensink, Indrapal I. Meshram, Andres Metspalu, Jie Mi, Kim F. Michaelsen, Kairit Mikkel, Jody C. Miller, Juan Francisco Miquel, J. Jaime Miranda, Marjeta Misigoj-Durakovic, Mostafa K. Mohamed, Kazem Mohammad, Noushin Mohammadifard, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Drude Molbo, Niels C. Moller, Denes Molnar, Charles K. Mondo, Eric A. Monterrubio, Kotsedi Daniel K. Monyeki, Leila B. Moreira, Alain Morejon, Luis A. Moreno, Karen Morgan, Erik Lykke Mortensen, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Thet Thet Mu, Maria Lorenza Muiesan, Martina Mueller-Nurasyid, Neil Murphy, Jaakko Mursu, Elaine M. Murtagh, Kamarul Imran Musa, Vera Musil, Gabriele Nagel, Harunobu Nakamura, Jana Namesna, Ei Ei K. Nang, Vinay B. Nangia, Martin Nankap, Sameer Narake, Eva Maria Navarrete-Munoz, Ilona Nenko, Martin Neovius, Flavio Nervi, Hannelore K. Neuhauser, Nguyen D. Nguyen, Quang Ngoc Nguyen, Ramfis E. Nieto-Martinez, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Teresa Norat, Davide Noto, Mohannad Al Nsour, Dermot O'Reilly, Angelica M. Ochoa-Aviles, Kyungwon Oh, Iman H. Olayan, Maria Teresa Anselmo Olinto, Maciej Oltarzewski, Mohd A. Omar, Altan Onat, Pedro Ordunez, Ana P. Ortiz, Merete Osler, Clive Osmond, Sergej M. Ostojic, Johanna A. Otero, Kim Overvad, Fred Michel Paccaud, Cristina Padez, Andrzej Pajak, Domenico Palli, Alberto Palloni, Luigi Palmieri, Songhomitra Panda-Jonas, Francesco Panza, Winsome R. Parnell, Mahboubeh Parsaeian, Mangesh S. Pednekar, Petra H. Peeters, Sergio Viana Peixoto, Alexandre C. Pereira, Cynthia M. Perez, Annette Peters, Niloofar Peykari, Son Thai Pham, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Francesco Pistelli, Freda Pitakaka, Aleksandra Piwonska, Jerzy Piwonski, Pedro Plans-Rubio, Bee Koon Poh, Miquel Porta, Marileen L. P. Portegies, Dimitrios Poulimeneas, Rajendra Pradeepa, Mathur Prashant, Jacqueline F. Price, Maria Puiu, Margus Punab, Radwan F. Qasrawi, Mostafa Qorbani, Tran Quoc Bao, Ivana Radic, Ricardas Radisauskas, Mahmudur Rahman, Olli Raitakari, Manu Raj, Sudha Ramachandra Rao, Ambady Ramachandran, Jacqueline Ramke, Rafel Ramos, Sanjay Rampal, Finn Rasmussen, Josep Redon, Paul Ferdinand M. Reganit, Robespierre Ribeiro, Elio Riboli, Fernando Rigo, Tobias Floris Rinke de Wit, Raphael M. Ritti-Dias, Juan A. Rivera, Sian M. Robinson, Cynthia Robitaille, Fernando Rodriguez-Artalejo, Maria del Cristo Rodriguez-Perez, Laura A. Rodriguez-Villamizar, Rosalba Rojas-Martinez, Nipa Rojroongwasinkul, Dora Romaguera, Kimmo Ronkainen, Annika Rosengren, Ian Rouse, Adolfo Rubinstein, Frank J. Ruehli, Ornelas Rui, Blanca Sandra Ruiz-Betancourt, Andrea R. V. Russo Horimoto, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S. Sachdev, Olfa Saidi, Benoit Salanave, Eduardo Salazar Martinez, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Jose Sanchez-Abanto, Sandjaja, Susana Sans, Diana A. Santos, Osvaldo Santos, Renata Nunes dos Santos, Rute Santos, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Savvas C. Savva, Marcia Scazufca, Angelika Schaffrath Rosario, Herman Schargrodsky, Anja Schienkiewitz, Ida Maria Schmidt, Ione J. Schneider, Constance Schultsz, Aletta E. Schutte, Aye Aye Sein, Idowu O. Senbanjo, Sadaf G. Sepanlou, Svetlana A. Shalnova, Jonathan E. Shaw, Kenji Shibuya, Youchan Shin, Rahman Shiri, Rosalynn Siantar, Abla M. Sibai, Antonio M. Silva, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjostrom, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Margaret C. Smith, Marieke B. Snijder, Hung-Kwan So, Eugene Sobngwi, Stefan Soderberg, Moesijanti Y. E. Soekatri, Vincenzo Solfrizzi, Emily Sonestedt, Thorkild I. A. Sorensen, Maroje Soric, Charles Sossa Jerome, Aicha Soumare, Jan A. Staessen, Gregor Starc, Maria G. Stathopoulou, Kaspar Staub, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, George S. Stergiou, Jochanan Stessman, Jutta Stieber, Doris Stoeckl, Tanja Stocks, Jakub Stokwiszewski, Gareth Stratton, Maria Wany Strufaldi, Chien-An Sun, Johan Sundstrom, Yn-Tz Sung, Jordi Sunyer, Paibul Suriyawongpaisal, Boyd A. Swinburn, Rody G. Sy, Lucjan Szponar, E. Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Line Tang, Xun Tang, Frank Tanser, Yong Tao, Jakob Tarp, Carolina B. Tarqui-Mamani, Anne Taylor, Felicite Tchibindat, Lutgarde Thijs, Betina H. Thuesen, Anne Tjonneland, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Roman Topor-Madry, Maties Torrent, Pierre Traissac, Antonia Trichopoulou, Dimitrios Trichopoulos, Oanh T. H. Trinh, Atul Trivedi, Lechaba Tshepo, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L. Turley, Per Tynelius, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Flora A. M. Ukoli, Hanno Ulmer, Belgin Unal, Gonzalo Valdivia, Susana Vale, Damaskini Valvi, Yvonne T. van der Schouw, Koen Van Herck, Hoang Van Minh, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Lars Vatten, Tomas Vega, Gustavo Velasquez-Melendez, Giovanni Veronesi, W. M. Monique Verschuren, Giovanni Viegi, Lucie Viet, Eira Viikari-Juntura, Paolo Vineis, Jesus Vioque, Jyrki K. Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Peter Vollenweider, Sari Voutilainen, Martine Vrijheid, Alisha N. Wade, Aline Wagner, Janette Walton, Wan Nazaimoon Wan Mohamud, Ming-Dong Wang, Qian Wang, Ya Xing Wang, S. Goya Wannamethee, Nicholas Wareham, Deepa Weerasekera, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Wiecek, Rainford J. Wilks, Johann Willeit, Bogdan Wojtyniak, Jyh Eiin Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C. Wu, JianFeng Wu, Shou Ling Wu, Haiquan Xu, Liang Xu, Uruwan Yamborisut, Weili Yan, Xiaoguang Yang, Nazan Yardim, Xingwang Ye, Panayiotis K. Yiallouros, Akihiro Yoshihara, Qi Sheng You, Novie O. Younger-Coleman, Ahmad F. Yusoff, Ahmad A. Zainuddin, Sabina Zambon, Tomasz Zdrojewski, Yi Zeng, Dong Zhao, Wenhua Zhao, Yingfeng Zheng, Maigeng Zhou, Dan Zhu, Esther Zimmermann, Julio Zuniga Cisneros

LANCET 387 ( 10026 ) 1377 - 1396 2016.4

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CD56(dim)CD16(high) and CD56(bright)CD16(-) cell percentages associated with maximum knee extensor strength and incidence of death in elderly

Hidenobu Senpuku, Hideo Miyazaki, Akihiro Yoshihara, Saori Yoneda, Naoki Narisawa, Taketo Kawarai, Naoki Nakagawa, Motohiko Miyachi, Akio Tada, Goichiro Yoshida, Mieko Shimada, Masaharu Ohashi, Mamoru Nishimuta, Yasuo Kimura, Yutaka Yoshitake

SPRINGERPLUS 5 244 2016.3

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PPAR gene polymorphism, C-reactive protein level, BMI and periodontitis in post-menopausal Japanese women Reviewed

Yangming Wang, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie

GERODONTOLOGY 33 ( 1 ) 44 - 51 2016.3

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PPAR gene polymorphism, C-reactive protein level, BMI and periodontitis in post-menopausal Japanese women

Yangming Wang, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie

GERODONTOLOGY 33 ( 1 ) 44 - 51 2016.3

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地域在住高齢者におけるフレイル(虚弱)と現在歯数との関連についての横断研究

佐藤美寿々, 岩崎正則, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 66 ( 1 ) 49 - 49 2016.1

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Effects of Periodontal Diseases on Diabetes-Related Medical Expenditure Invited Reviewed

Masanori Iwasaki, Misuzu Sato, Akihiro Yoshihara, Hideo Miyazaki

Current Oral Health Reports 3 ( 1 ) 7 - 13 2016

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自立高齢者における飲酒習慣と歯周組織状態との関係 Reviewed

諏訪間加奈, 葭原明弘, 渡邊令子, ステガロユ・ロクサーナ, 柴田佐都子, 宮崎秀夫

新潟歯学会雑誌 45 ( 2 ) 100 - 100 2015.12

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歯科診療所構成員と医院の担える診療内容との関連

皆川久美子, 葭原明弘

有病者歯科医療 24 ( 4 ) 313 - 313 2015.12

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Oral health status in relation to cognitive function among older Japanese. Reviewed International journal

Masanori Iwasaki, Yumi Kimura, Akihiro Yoshihara, Hiroshi Ogawa, Takayuki Yamaga, Misuzu Sato, Taizo Wada, Ryota Sakamoto, Yasuko Ishimoto, Eriko Fukutomi, Wenling Chen, Hissei Imai, Michiko Fujisawa, Kiyohito Okumiya, George W Taylor, Toshihiro Ansai, Hideo Miyazaki, Kozo Matsubayashi

Clinical and experimental dental research 1 ( 1 ) 3 - 9 2015.10

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Epidemiologic data examining the relationship between oral health status and cognitive status are sparse, especially in Asian populations. This study aimed to assess whether periodontal disease and tooth loss were related to cognitive impairment among older Japanese. Study participants were 291 Japanese (101 men and 190 women, average age: 80.9 years), classified into three groups based on a clinical examination of oral health status: no periodontal disease, periodontal disease, and edentulous. Periodontal disease was defined using criteria recommended in the consensus report of the European Workshop in Periodontology with a modification. Cognitive impairment was defined using the results of the Mini-mental State Examination (MMSE) and Hasegawa Dementia Scale-Revised (HDS-R) scores. Multivariable logistic regression analyses assessed the relationship of the three-category oral health status variable (reference category = no periodontal disease) with low MMSE score (≤23) and low HDS-R score (≤20). Age, gender, years of education, body mass index, smoking status, drinking behavior, and history of cardiovascular disease were tested as potential confounders in the multivariable models. Periodontal disease and edentulous were significantly associated with greater odds of low cognitive performance after controlling for potential confounders. The multivariable adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for low MMSE score associated with periodontal disease and edentulous were 2.21 (1.01-4.84) and 2.28 (1.06-4.90), respectively. The multivariable adjusted ORs (95% CIs) for low HDS-R score associated with periodontal disease and edentulous were 4.85 (1.29-18.15) and 3.86 (1.05-14.20), respectively. Poor oral health status was significantly associated with cognitive impairment among community-dwelling older Japanese. Additional well-controlled longitudinal studies are needed to elucidate whether there may be a possible cause-and-effect relationship between oral health status and cognitive function.

DOI： 10.1002/cre2.2

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Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331288 participants Reviewed

Goodarz Danaei, Saman Fahimi, Yuan Lu, Bin Zhou, Kaveh Hajifathalian, Mariachiara Di Cesare, Wei-Cheng Lo, Barbara Reis-Santos, Melanie J. Cowan, Jonathan E. Shaw, James Bentham, John K. Lin, Honor Bixby, Dianna Magliano, Pascal Bovet, J. Jaime Miranda, Young-Ho Khang, Gretchen A. Stevens, Leanne M. Riley, Mohammed K. Ali, Majid Ezzati, Ziad A. Abdeen, Khalid Abdul Kadir, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Wichai Aekplakorn, Carlos A. Aguilar-Salinas, Alireza Ahmadvand, Mohannad Al Nsour, Ala'a Alkerwi, Philippe Amouyel, Lars Bo Andersen, Sigmund A. Anderssen, Dolores S. Andrade, Ranjit Mohan Anjana, Hajer Aounallah-Skhiri, Tahir Aris, Nimmathota Arlappa, Dominique Arveiler, Felix K. Assah, Maria Avdicova, Nagalla Balakrishna, Piotr Bandosz, Carlo M. Barbagallo, Alberto Barcelo, Anwar M. Batieha, Louise A. Baur, Habiba Ben Romdhane, Antonio Bernabe-Ortiz, Santosh K. Bhargava, Yufang Bi, Peter Bjerregaard, Cecilia Bjorkelund, Margaret Blake, Anneke Blokstra, Simona Bo, Bernhard O. Boehm, Carlos P. Boissonnet, Pascal Bovet, Imperia Brajkovich, Juergen Breckenkamp, Lizzy M. Brewster, Garry R. Brian, Graziella Bruno, Anna Bugge, Antonio Cabrera de Leon, Gunay Can, Ana Paula C. Candido, Vincenzo Capuano, Maria J. Carvalho, Felipe F. Casanueva, Carmelo A. Caserta, Katia Castetbon, Snehalatha Chamukuttan, Nishi Chaturvedi, Chien-Jen Chen, Fangfang Chen, Shuohua Chen, Ching-Yu Cheng, Angela Chetrit, Shu-Ti Chiou, Yumi Cho, Jerzy Chudek, Renata Cifkova, Frank Claessens, Hans Concin, Cyrus Cooper, Rachel Cooper, Simona Costanzo, Dominique Cottel, Chris Cowell, Ana B. Crujeiras, Graziella D'Arrigo, Jean Dallongeville, Rachel Dankner, Luc Dauchet, Giovanni de Gaetano, Stefaan De Henauw, Mohan Deepa, Abbas Dehghan, Klodian Dhana, Augusto F. Di Castelnuovo, Shirin Djalalinia, Kouamelan Doua, Wojciech Drygas, Yong Du, Eruke E. Egbagbe, Robert Eggertsen, Jalila El Ati, Roberto Elosua, Rajiv T. Erasmus, Cihangir Erem, Gul Ergor, Louise Eriksen, Jorge Escobedo-De la Penaa, Caroline H. Fall, Farshad Farzadfar, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernandez-Berges, Marika Ferrari, Catterina Ferreccio, Joseph D. Finn, Bernhard Foger, Leng Huat Foo, Heba M. Fouad, Damian K. Francis, Maria do Carmo Franco, Oscar H. Franco, Guillermo Frontera, Takuro Furusawa, Zbigniew Gaciong, Andrzej Galbarczyk, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Johanna M. Geleijnse, Anoosheh Ghasemain, Simona Giampaoli, Francesco Gianfagna, Jonathan Giovannelli, Marcela Gonzalez Gross, Juan P. Gonzalez Rivas, Mariano Bonet Gorbea, Frederic Gottrand, Janet F. Grant, Tomasz Grodzicki, Anders Grontved, Grabriella Gruden, Dongfeng Gu, Ong Peng Guan, Ramiro Guerrero, Idris Guessous, Andre L. Guimaraes, Laura Gutierrez, Rebecca Hardy, Rachakulla Hari Kumar, Jiang He, Christin Heidemann, Ilpo Tapani Hihtaniemi, Sai Yin Ho, Suzanne C. Ho, Albert Hofman, Andrea R. V. Russo, Claudia M. Hormiga, Bernardo L. Horta, Leila Houti, Abdullatif S. Hussieni, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G. Iannone, Mohsen M. Ibrahim, Nayu Ikeda, M. Arfan Ikram, Vilma E. Irazola, Muhammad Islam, Masanori Iwasaki, Jeremy M. Jacobs, Tazeen Jafar, Grazyna Jasienska, Chao Qiang Jiang, Jost B. Jonas, Pradeep Joshi, Anthony Kafatos, Ofra Kalter-Leibovici, Amir Kasaeian, Joanne Katz, Prabhdeep Kaur, Maryam Kavousi, Roya Kelishadi, Andre P. Kengne, Mathilde Kersting, Yousef Saleh Khader, Young-Ho Khang, Stefan Kiechl, Jeongseon Kim, Yutaka Kiyohara, Patrick Kolsteren, Paul Korrovits, Seppo Koskinen, Wolfgang Kratzer, Daan Kromhout, Krzysztof Kula, Pawel Kurjata, Catherine Kyobutungi, Carl Lachat, Youcef Laid, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Avula Laxmaiah, Catherine Leclercq, Jeannette Lee, Jeonghee Lee, Terho Lehtimaki, Rampal Lekhraj, Luz M. Leon-Munoz, Yanping Li, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Lauren Lissner, Roberto Lorbeer, Jose Eugenio Lozano, Annamari Lundqvist, Per Lytsy, Guansheng Ma, George L. L. Machado-Coelho, Suka Machi, Stefania Maggi, Dianna Magliano, Marcia Makdisse, Kodavanti Mallikharjuna Rao, Yannis Manios, Enzo Manzato, Paula Margozzini, Pedro Marques-Vidal, Reynaldo Martorell, Shariq R. Masoodi, Tandi E. Matsha, Jean Claude N. Mbanya, Shelly R. McFarlane, Stephen T. McGarvey, Stela McLachlan, Breige A. McNulty, Sounnia Mediene-Benchekor, Aline Meirhaeghe, Ana Maria B. Menezes, Shahin Merat, Indrapal I. Meshram, Jie Mi, Juan Francisco Miquel, J. Jaime Miranda, Mostafa K. Mohamed, Kazem Mohammad, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Niels C. Moller, Denes Molnar, Charles K. Mondo, Luis A. Moreno, Karen Morgan, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Maria L. Muiesan, Martina Muller-Nurasyid, Jaakko Mursu, Gabriele Nagel, Jana Namesna, Ei Ei K. Nang, Vinay B. Nangia, Eva Maria Navarrete-Munoz, Ndeye Coumba Ndiaye, Flavio Nervi, Nguyen D. Nguyen, Ramfi S. E. Nieto-Martinez, Guang Ning, Toshiharu Ninomiya, Marianna Noale, Davide Noto, Angelica M. Ochoa-Aviles, Kyungwon Oh, Altan Onat, Clive Osmond, Johanna A. Otero, Luigi Palmieri, Songhomitra Panda-Jonas, Francesco Panza, Mahboubeh Parsaeian, Sergio Viana Peixoto, Alexandre C. Pereira, Annette Peters, Niloofar Peykari, Aida Pilav, Freda Pitakaka, Aleksandra Piwonska, Jerzy Piwonski, Pedro Plans-Rubio, Miquel Porta, Marileen L. P. Portegies, Hossein Poustchi, Rajendra Pradeepa, Jacqueline F. Price, Margus Punab, Radwan F. Qasrawi, Mostafa Qorbani, Olli Raitakari, Sudha Ramachandra Rao, Ambady Ramachandran, Rafel Ramos, Sanjay Rampal, Wolfgang Rathmann, Josep Redon, Paul Ferdinand M. Reganit, Fernando Rigo, Sian M. Robinson, Cynthia Robitaille, Laura A. Rodriguez, Fernando Rodriguez-Artalejo, Maria del Cristo Rodriguez-Perez, Rosalba Rojas-Martinez, Dora Romaguera, Annika Rosengren, Adolfo Rubinstein, Ornelas Rui, Blanca Sandra Ruiz-Betancourt, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S. Sachdev, Olfa Saidi, Sibel Sakarya, Benoit Salanave, Jukka T. Salonen, Massimo Salvetti, Jose Sanchez-Abanto, Renata Nunes, Rute Santos, Luis B. Sardinha, Marcia Scazufca, Herman Schargrodsky, Christa Scheidt-Nave, Jonathan E. Shaw, Kenji Shibuya, Youchan Shin, Rahman Shiri, Rosalynn Siantar, Abla M. Sibai, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjostrom, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Marieke B. Snijder, Vincenzo Solfrizzi, Emily Sonestedt, Aicha Soumare, Jan A. Staessen, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, Jochanan Stessman, Doris Stockl, Jakub Stokwiszewski, Maria Wany Strufaldi, Chien-An Sun, Johan Sundstrom, Paibul Suriyawongpaisal, Rody G. Sy, E. Shyong Tai, Mohammed Tarawneh, Carolina B. Tarqui-Mamani, Lutgarde Thijs, Janne S. Tolstrup, Murat Topbas, Maties Torrent, Pierre Traissac, Oanh T. H. Trinh, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Maria L. Turley, Christophe Tzourio, Peter Ueda, Flora M. Ukoli, Hanno Ulmer, Gonzalo Valdivia, Irene G. M. Van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Tomas Vega, Gustavo Velasquez-Melendez, Giovanni Veronesi, Monique Verschuren, Jesus Vioque, Jyrki Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Peter Vollenweider, Sari Voutilainen, Alisha N. Wade, Aline Wagner, Janette Walton, Wan Nazaimoon Wan Mohamud, Ming-Dong Wang, Ya Xing Wang, S. Goya Wannamethee, Deepa Weerasekera, Peter H. Whincup, Kurt Widhalm, Andrzej Wiecek, Rainford J. Wilks, Johann Willeit, Bogdan Wojtyniak, Tien Yin Wong, Jean Woo, Mark Woodward, Aleksander Giwercman Wu, Frederick C. Wu, Shou Ling Wu, Haiquan Xu, Xiaoguang Yang, Xingwang Ye, Akihiro Yoshihara, Novie O. Younger-Coleman, Sabina Zambon, Abdul Hamid Zargar, Tomasz Zdrojewski, Wenhua Zhao, Yingfeng Zheng

LANCET DIABETES & ENDOCRINOLOGY 3 ( 8 ) 624 - 637 2015.8

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DOI： 10.1016/S2213-8587(15)00129-1

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The Interaction Between beta-3 Adrenergic Receptor and Peroxisome Proliferator-Activated Receptor Gamma Gene Polymorphism to Periodontal Disease in Community-Dwelling Elderly Japanese Reviewed

Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Yanming Wang, Hideo Miyazaki, Hiromasa Yoshie, Kazutoshi Nakamura

JOURNAL OF PERIODONTOLOGY 86 ( 8 ) 955 - 963 2015.8

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DOI： 10.1902/jop.2015.140472

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障害支援区分からみた知的障害者の口腔保健支援のあり方の検討 Reviewed

植木麻有子, 石川裕子, 米澤大輔, 高橋英樹, 大内章嗣, 葭原明弘

日本歯科衛生学会雑誌 10 ( 1 ) 34 - 42 2015.8

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Number of teeth and 5-year mortality in an elderly population Reviewed

Toshinobu Hirotomi, Akihiro Yoshihara, Hiroshi Ogawa, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 43 ( 3 ) 226 - 231 2015.6

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DOI： 10.1111/cdoe.12146

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高齢者における食事パターンと現在歯数の関連

木村秀喜, 渡邊智子, 鈴木亜夕帆, 岩崎正則, 葭原明弘, 宮崎秀夫

新潟歯学会雑誌 45 ( 1 ) 27 - 28 2015.6

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Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women Reviewed

Y. Hanai, N. Sugita, Y. Wang, A. Yoshihara, M. Iwasaki, H. Miyazaki, K. Nakamura, H. Yoshie

ARCHIVES OF ORAL BIOLOGY 60 ( 4 ) 533 - 539 2015.4

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DOI： 10.1016/j.archoralbio.2014.12.005

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Relationship between metabolic syndrome and periodontitis in 80-year-old Japanese subjects Reviewed

K. Minagawa, M. Iwasaki, H. Ogawa, A. Yoshihara, H. Miyazaki

JOURNAL OF PERIODONTAL RESEARCH 50 ( 2 ) 173 - 179 2015.4

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DOI： 10.1111/jre.12190

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Longitudinal Relationship Between Metabolic Syndrome and Periodontal Disease Among Japanese Adults Aged >= 70 Years: The Niigata Study

Masanori Iwasaki, Misuzu Sato, Kumiko Minagawa, Michael C. Manz, Akihiro Yoshihara, Hideo Miyazaki

JOURNAL OF PERIODONTOLOGY 86 ( 4 ) 491 - 498 2015.4

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DOI： 10.1902/jop.2015.140398

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地域在住高齢者における歯・口腔の健康が認知機能検査スコアに与える影響 Reviewed

岩崎正則, 葭原明弘, 小川祐司, 山賀孝之, 佐藤美寿々, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 65 ( 2 ) 195 - 195 2015.4

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歯科医師および歯科衛生士数と医院の担える診療内容との関連

皆川久美子, 葭原明弘, 荒井節男, 清田義和, 宮崎秀夫

口腔衛生学会雑誌 65 ( 2 ) 255 - 255 2015.4

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成人女性に対する歯周病予防の取り組みへの提案

皆川久美子, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 65 ( 1 ) 53 - 53 2015.1

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Association between dental status and food diversity among older Japanese Reviewed

Masanori Iwasaki, Y. Kimura, A. Yoshihara, H. Ogawa, T. Yamaga, T. Takiguchi, T. Wada, R. Sakamoto, Y. Ishimoto, E. Fukutomi, W. Chen, H. Imai, M. Fujisawa, K. Okumiya, M. C. Manz, H. Miyazaki, K. Matsubayashi

Community Dental Health 32 ( 2 ) 104 - 110 2015

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Language：English Publishing type：Research paper (scientific journal) Publisher：Dennis Barber Ltd

DOI： 10.1922/CDH_3502Iwasaki07

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Low dietary diversity among older Japanese adults with impaired dentition Reviewed

Iwasaki M, Kimura Y, Yoshihara A, Ogawa H, Yamaga T, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Vhen WL, Imai H, Fujisawa M, Okumiya K, Manz MC, Ansai T, Miyazaki H, Matsubayashi K

Journal of Dentistry and Oral Hygiene 7 ( 4 ) 40 - 43 2015

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DOI： 10.5897/JDOH2014.0142.

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Analysis of tooth brushing cycles Reviewed

Yuki Tosaka, Kuniko Nakakura-Ohshima, Nozomi Murakami, Rikako Ishii, Issei Saitoh, Yoko Iwase, Akihiro Yoshihara, Akitsugu Ohuchi, Haruaki Hayasaki

CLINICAL ORAL INVESTIGATIONS 18 ( 8 ) 2045 - 2053 2014.11

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DOI： 10.1007/s00784-013-1172-3

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Analysis of tooth brushing cycles Reviewed

Yuki Tosaka, Kuniko Nakakura-Ohshima, Nozomi Murakami, Rikako Ishii, Issei Saitoh, Yoko Iwase, Akihiro Yoshihara, Akitsugu Ohuchi, Haruaki Hayasaki

CLINICAL ORAL INVESTIGATIONS 18 ( 8 ) 2045 - 2053 2014.11

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DOI： 10.1007/s00784-013-1172-3

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Oral health status: relationship to nutrient and food intake among 80-year-old Japanese adults Reviewed

Masanori Iwasaki, George W. Taylor, Michael C. Manz, Akihiro Yoshihara, Misuzu Sato, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 42 ( 5 ) 441 - 450 2014.10

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DOI： 10.1111/cdoe.12100

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Oral health status: relationship to nutrient and food intake among 80-year-old Japanese adults Reviewed

Masanori Iwasaki, George W. Taylor, Michael C. Manz, Akihiro Yoshihara, Misuzu Sato, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 42 ( 5 ) 441 - 450 2014.10

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DOI： 10.1111/cdoe.12100

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Comparison of periodontal conditions among three elderly populations in Japan and Germany Reviewed

Toshinobu Hirotomi, Thomas Kocher, Akihiro Yoshihara, Reiner Biffar, Wolfgang Micheelis, Thomas Hoffmann, Hideo Miyazaki, Birte Holtfreter

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 7 ) 633 - 642 2014.7

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DOI： 10.1111/jcpe.12267

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Comparison of periodontal conditions among three elderly populations in Japan and Germany Reviewed

Toshinobu Hirotomi, Thomas Kocher, Akihiro Yoshihara, Reiner Biffar, Wolfgang Micheelis, Thomas Hoffmann, Hideo Miyazaki, Birte Holtfreter

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 7 ) 633 - 642 2014.7

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DOI： 10.1111/jcpe.12267

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Association between low renal function and tooth loss over 5 years Reviewed

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

GERODONTOLOGY 31 ( 2 ) 111 - 116 2014.6

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DOI： 10.1111/ger.12015

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Association between low renal function and tooth loss over 5 years Reviewed

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

GERODONTOLOGY 31 ( 2 ) 111 - 116 2014.6

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DOI： 10.1111/ger.12015

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高齢者における歯周病が医療費に及ぼす影響

佐藤美寿々, 岩崎正則, 葭原明弘, 宮崎秀夫

新潟歯学会雑誌 44 ( 1 ) 56 - 56 2014.6

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The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese Reviewed

Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 5 ) 460 - 466 2014.5

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DOI： 10.1111/jcpe.12235

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The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese Reviewed

Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 5 ) 460 - 466 2014.5

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DOI： 10.1111/jcpe.12235

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乳幼児健診に併設し歯科衛生士が実施する個別指導による歯科保健行動の変容

皆川久美子, 葭原明弘, 金子昇, 林悠子, 藤山友紀, 宮崎秀夫

口腔衛生学会雑誌 64 ( 2 ) 245 - 245 2014.4

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8020(ハチマルニイマル)と全身の健康の関連に関する医療費分析調査

岩崎正則, 佐藤美寿々, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 64 ( 2 ) 164 - 164 2014.4

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Mandibular inferior cortex erosion as a sign of elevated total serum calcium in elderly people: a 9-year follow-up study Reviewed

B. Kiswanjaya, A. Yoshihara, H. Miyazaki

DENTOMAXILLOFACIAL RADIOLOGY 43 ( 3 ) 2014.3

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DOI： 10.1259/dmfr.20130341

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保育園児に対する口腔機能向上訓練の構音機能への効果について Reviewed

平野真弓, 葭原明弘, 宮﨑秀夫

新潟歯学会雑誌 44 27 - 32 2014

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Serum antibody to Porphyromonas gingivalis in metabolic syndrome among an older Japanese population Reviewed

M Iwasaki, K Minagawa, M Sato, N Kaneko, S Imai, A Yoshihara, H Miyazaki

Gerodontology 2014

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臨床指針 Reviewed

八重垣健, 秋房住郎, 天野敦雄, 薄井由枝, 葭原明弘

日本口腔衛生学会雑誌 64 296 - 298 2014

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High serum 25-hydroxyvitamin D levels do not retard postmenopausal bone loss in Japanese women: the Yokogoshi study Reviewed

Kaori Kitamura, Kazutoshi Nakamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

ARCHIVES OF OSTEOPOROSIS 8 ( 1-2 ) 153 2013.12

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DOI： 10.1007/s11657-013-0153-0

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Association between low bone mineral density and clinical attachment loss in Japanese postmenopausal females Reviewed

Masanori Iwasaki, George W. Taylor, Kazutoshi Nakamura, Akihiro Yoshihara, Hideo Miyazaki

Journal of Periodontology 84 ( 12 ) 1708 - 1716 2013.12

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DOI： 10.1902/jop.2013.120613

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High serum 25-hydroxyvitamin D levels do not retard postmenopausal bone loss in Japanese women: the Yokogoshi study

Kaori Kitamura, Kazutoshi Nakamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

ARCHIVES OF OSTEOPOROSIS 8 ( 1-2 ) 153 2013.12

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DOI： 10.1007/s11657-013-0153-0

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Serum albumin levels and 10-year tooth loss in a 70-year-old population Reviewed

A. Yoshihara, M. Iwasaki, H. Ogawa, H. Miyazaki

JOURNAL OF ORAL REHABILITATION 40 ( 9 ) 678 - 685 2013.9

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DOI： 10.1111/joor.12083

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Evaluation of chewing ability and its relationship with activities of daily living, depression, cognitive status and food intake in the community-dwelling elderly Reviewed

Yumi Kimura, Hiroshi Ogawa, Akihiro Yoshihara, Takayuki Yamaga, Tomoya Takiguchi, Taizo Wada, Ryota Sakamoto, Yasuko Ishimoto, Eriko Fukutomi, Wenling Chen, Michiko Fujisawa, Kiyohito Okumiya, Kuniaki Otsuka, Hideo Miyazaki, Kozo Matsubayashi

GERIATRICS & GERONTOLOGY INTERNATIONAL 13 ( 3 ) 718 - 725 2013.7

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DOI： 10.1111/ggi.12006

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Peroxisome proliferator-activated receptor (PPAR) gamma polymorphism, vitamin D, bone mineral density and periodontitis in postmenopausal women Reviewed

Y. Wang, N. Sugita, A. Yoshihara, M. Iwasaki, H. Miyazaki, K. Nakamura, H. Yoshie

ORAL DISEASES 19 ( 5 ) 501 - 506 2013.7

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DOI： 10.1111/odi.12032

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Evaluation of chewing ability and its relationship with activities of daily living, depression, cognitive status and food intake in the community-dwelling elderly

Yumi Kimura, Hiroshi Ogawa, Akihiro Yoshihara, Takayuki Yamaga, Tomoya Takiguchi, Taizo Wada, Ryota Sakamoto, Yasuko Ishimoto, Eriko Fukutomi, Wenling Chen, Michiko Fujisawa, Kiyohito Okumiya, Kuniaki Otsuka, Hideo Miyazaki, Kozo Matsubayashi

GERIATRICS & GERONTOLOGY INTERNATIONAL 13 ( 3 ) 718 - 725 2013.7

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DOI： 10.1111/ggi.12006

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口腔衛生学における疫学研究のエビデンスとその応用(ポストドクトリアルセミナー)

八重垣健, 葭原明弘

口腔衛生学会雑誌 63 ( 2 ) 133 - 134 2013.4

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O-10 地域在住女性高齢者における腎機能と歯周組織の炎症部位面積に関する横断調査(一般口演)

岩崎正則, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 63 ( 2 ) 148 - 148 2013.4

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Dietary antioxidants and periodontal disease in community-based older Japanese: a 2-year follow-up study Reviewed

Masanori Iwasaki, Paula Moynihan, Michael C. Manz, George W. Taylor, Akihiro Yoshihara, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

PUBLIC HEALTH NUTRITION 16 ( 2 ) 330 - 338 2013.2

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DOI： 10.1017/S1368980012002637

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Dietary antioxidants and periodontal disease in community-based older Japanese: a 2-year follow-up study

Masanori Iwasaki, Paula Moynihan, Michael C. Manz, George W. Taylor, Akihiro Yoshihara, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

PUBLIC HEALTH NUTRITION 16 ( 2 ) 330 - 338 2013.2

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DOI： 10.1017/S1368980012002637

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高齢者における咀嚼能力と体力の関係について

瀧口知彌, 小川祐司, 葭原明弘, 山賀孝之, 宮崎秀夫

口腔衛生学会雑誌 63 ( 1 ) 44 - 44 2013.1

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Questionnaire Survey on Oral Symptoms of Menopausal Women and Cooperation Between Doctors and Dentists. Reviewed

Matsuki, T, Ito, K, Funayama, S, Yoshihara, A, Masumi, S

Int J Oral-Med Sci 12 ( 1 ) 21 - 28 2013

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Objective: Xerostomia, temporomandibular disorder, and periodontal disease are frequently seen in menopausal women. However, few studies have reported the prevalence of oralsymptoms during menopause or the cooperation between doctors at outpatient clinics for women and dentists. The purpose of this study was to investigate the frequency of oral symptoms and the cooperation between doctors at outpatient clinics for women and dentists. Methods: A questionnaire was sent to 380 outpatient clinics for women in Japan. The questionnaire included characteristics for the person completing it, staff structure,cooperation with medicalspecialists, the existence of oralsymptoms, details of these symptoms, cooperation with dentists, and space for free responses. Results: The survey response rate was 57.9% (220 of 380 institutions). Most respondents (81.6%) thought that female sex hormones influenced the mouth, and 79.4% had encountered oralsymptoms. The most frequently encountered symptoms were oral dryness, taste disorder, and burning sensation of the mouth. The necessity of cooperation between doctors and dentists was recognized by 63.1%. Staff that recognised the influence of female hormones on the mouth were significantly more likely than others to acknowledge the importance of cooperation (p<0.01). However, as only half of the staff had referred patients to a dental clinic, it seems possible that patients whose symptoms could have been alleviated by dentists were not appropriately managed. Conclusion: Although oral symptoms can relate to menopause, the cooperation between doctors and dentists is poor. Improved cooperation may relieve not only oral complaints but also systemic menopausal symptoms.

DOI： 10.5466/ijoms.12.21

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Tooth loss, periodontal disease, and mineral content of calcium and magnesium in the diet or urine in the elderly Reviewed

A Yoshihara, R Watanabe, M Nishimuta, H Miyazaki

The Journal of Aging Research & Clinical Practice 2 126 - 130 2013

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The Relationship among Periodontal Condition, Serum Lipid, and Electrocardiographic Abnormalities in the Elderly Reviewed

L Hanindriyo, A Yoshihara, T Mirotomi, H Miyazaki

the Open Journal of Stomatology 3 457 - 463 2013

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自立高齢者の加齢による現在歯数と食事のエネルギー密度の関連

安藝真里子, 渡邊令子, 村松芳多子, 葭原明弘, 宮崎秀夫

新潟歯学会雑誌 42 ( 2 ) 137 - 137 2012.12

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Serum Antibody to Porphyromonas gingivalis in Chronic Kidney Disease Reviewed

M. Iwasaki, G. W. Taylor, M. C. Manz, N. Kaneko, S. Imai, A. Yoshihara, H. Miyazaki

JOURNAL OF DENTAL RESEARCH 91 ( 9 ) 828 - 833 2012.9

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DOI： 10.1177/0022034512455063

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Change in bone mineral density and tooth loss in Japanese community-dwelling postmenopausal women: a 5-year cohort study

Masanori Iwasaki, Kazutoshi Nakamura, Akihiro Yoshihara, Hideo Miyazaki

JOURNAL OF BONE AND MINERAL METABOLISM 30 ( 4 ) 447 - 453 2012.7

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DOI： 10.1007/s00774-011-0337-x

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Change in bone mineral density and tooth loss in Japanese community-dwelling postmenopausal women: a 5-year cohort study Reviewed

Masanori Iwasaki, Kazutoshi Nakamura, Akihiro Yoshihara, Hideo Miyazaki

JOURNAL OF BONE AND MINERAL METABOLISM 30 ( 4 ) 447 - 453 2012.7

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DOI： 10.1007/s00774-011-0337-x

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Physical performance and 10-year mortality in a 70-year-old community-dwelling population

Yutaka Takata, Mieko Shimada, Toshihiro Ansai, Yutaka Yoshitake, Mamoru Nishimuta, Naoki Nakagawa, Masaharu Ohashi, Akihiro Yoshihara, Hideo Miyazaki

AGING CLINICAL AND EXPERIMENTAL RESEARCH 24 ( 3 ) 257 - 264 2012.6

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Physical performance and 10-year mortality in a 70-year-old community-dwelling population Reviewed

Yutaka Takata, Mieko Shimada, Toshihiro Ansai, Yutaka Yoshitake, Mamoru Nishimuta, Naoki Nakagawa, Masaharu Ohashi, Akihiro Yoshihara, Hideo Miyazaki

AGING CLINICAL AND EXPERIMENTAL RESEARCH 24 ( 3 ) 257 - 264 2012.6

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The association between renal function and tooth loss in Japanese community-dwelling postmenopausal women

Akihiro Yoshihara, Kazutoshi Nakamura, Hideo Miyazaki

GERODONTOLOGY 29 ( 2 ) E363 - E367 2012.6

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DOI： 10.1111/j.1741-2358.2011.00481.x

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The association between renal function and tooth loss in Japanese community-dwelling postmenopausal women Reviewed

Akihiro Yoshihara, Kazutoshi Nakamura, Hideo Miyazaki

GERODONTOLOGY 29 ( 2 ) E363 - E367 2012.6

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DOI： 10.1111/j.1741-2358.2011.00481.x

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地域在住高齢者におけるメタボリックシンドロームと歯周病の関連

坂入久美子, 岩崎正則, 小川祐司, 葭原明弘, 宮崎秀夫

新潟歯学会雑誌 42 ( 1 ) 63 - 64 2012.6

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Association Between Volatile Sulfur Compounds and Periodontal Disease Progression in Elderly Non-Smokers

Yuka Makino, Takayuki Yamaga, Akihiro Yoshihara, Kaname Nohno, Hideo Miyazaki

JOURNAL OF PERIODONTOLOGY 83 ( 5 ) 635 - 643 2012.5

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DOI： 10.1902/jop.2011.110275

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Association Between Volatile Sulfur Compounds and Periodontal Disease Progression in Elderly Non-Smokers Reviewed

Yuka Makino, Takayuki Yamaga, Akihiro Yoshihara, Kaname Nohno, Hideo Miyazaki

JOURNAL OF PERIODONTOLOGY 83 ( 5 ) 635 - 643 2012.5

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DOI： 10.1902/jop.2011.110275

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縦断調査からみた地域高齢者の歯列欠損形態と咀嚼能力の経年変化

佐藤直子, 野村修一, 昆はるか, 櫻井直樹, 葭原明弘, 宮崎秀夫, 河野正司

日本補綴歯科学会誌 4 ( 特別号 ) 255 - 255 2012.5

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Tooth-related risk factors for tooth loss in community-dwelling elderly people Reviewed

Toshinobu Hirotomi, Akihiro Yoshihara, Hiroshi Ogawa, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 40 ( 2 ) 154 - 163 2012.4

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DOI： 10.1111/j.1600-0528.2011.00648.x

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Tooth-related risk factors for tooth loss in community-dwelling elderly people

Toshinobu Hirotomi, Akihiro Yoshihara, Hiroshi Ogawa, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 40 ( 2 ) 154 - 163 2012.4

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DOI： 10.1111/j.1600-0528.2011.00648.x

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Association between periodontitis and systemic bone mineral density in Japanese community-dwelling postmenopausal women

Osamu Takahashi, Akihiro Yoshihara, Kazutoshi Nakamura, Hideo Miyazaki

JOURNAL OF DENTISTRY 40 ( 4 ) 304 - 311 2012.4

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DOI： 10.1016/j.jdent.2012.01.005

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Association between periodontitis and systemic bone mineral density in Japanese community-dwelling postmenopausal women Reviewed

Osamu Takahashi, Akihiro Yoshihara, Kazutoshi Nakamura, Hideo Miyazaki

JOURNAL OF DENTISTRY 40 ( 4 ) 304 - 311 2012.4

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DOI： 10.1016/j.jdent.2012.01.005

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地域在住高齢者におけるメタボリックシンドロームと歯周病の関連

坂入久美子, 岩崎正則, 小川祐司, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 62 ( 2 ) 217 - 217 2012.4

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Periodontal Disease and Decreased Kidney Function in Japanese Elderly Reviewed

Masanori Iwasaki, George W. Taylor, Willem Nesse, Arjan Vissink, Akihiro Yoshihara, Hideo Miyazaki

AMERICAN JOURNAL OF KIDNEY DISEASES 59 ( 2 ) 202 - 209 2012.2

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DOI： 10.1053/j.ajkd.2011.08.027

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Periodontal Disease and Decreased Kidney Function in Japanese Elderly

Masanori Iwasaki, George W. Taylor, Willem Nesse, Arjan Vissink, Akihiro Yoshihara, Hideo Miyazaki

AMERICAN JOURNAL OF KIDNEY DISEASES 59 ( 2 ) 202 - 209 2012.2

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DOI： 10.1053/j.ajkd.2011.08.027

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Relations of Serum Ascorbic Acid and alpha-tocopherol to Periodontal Disease Reviewed

M. Iwasaki, M. C. Manz, G. W. Taylor, A. Yoshihara, H. Miyazaki

JOURNAL OF DENTAL RESEARCH 91 ( 2 ) 167 - 172 2012.2

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DOI： 10.1177/0022034511431702

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Serum albumin (SA) levels and 10-year mortality in a community-dwelling 70-year-old population Reviewed

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

ARCHIVES OF GERONTOLOGY AND GERIATRICS 54 ( 1 ) 39 - 43 2012.1

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DOI： 10.1016/j.archger.2011.02.018

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Serum albumin (SA) levels and 10-year mortality in a community-dwelling 70-year-old population

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

ARCHIVES OF GERONTOLOGY AND GERIATRICS 54 ( 1 ) 39 - 43 2012.1

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DOI： 10.1016/j.archger.2011.02.018

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乳幼児健診に併設し実施する個別指導による歯科保健行動の変容

坂入久美子, 葭原明弘, 金子昇, 林悠子, 藤山友紀, 宮崎秀夫

口腔衛生学会雑誌 62 ( 1 ) 63 - 64 2012.1

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高齢者における咀嚼能力と体力およびうつ傾向との関係について

瀧口知彌, 葭原明弘, 小川祐司, 山賀孝之, 宮崎秀夫

口腔衛生学会雑誌 62 ( 1 ) 64 - 64 2012.1

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Association Between Glucan Synthesis by Streptococcus mutans and Caries Incidence in Schoolchildren Receiving a Fluoride Mouth Rinse Reviewed

Umetsu, Hidehiro, Kaneko, Noboru, Yoshihara, Akihiro, Sakuma, Shihoko, Hanada, Nobuhiro, Miyazaki, Hideo

ORAL HEALTH & PREVENTIVE DENTISTRY 10 ( 2 ) 161 - 166 2012

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The relationship between masticatory ability and assessment items of metabolic syndrome in adults aged 60's years old Reviewed

Takahashi Junko, Yoshihara Akihiro, Hayami Ryu

42 ( 1 ) 21 - 26 2012

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Association of dental status with vegetable intake in an elderly population Reviewed

T Hirotomi, A Yoshihara, H Ogawa, H Miyazaki

The Journal of Aging Research & Clinical Practice 1 84 - 87 2012

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Association between Masticatory Performance and One-leg Standing Time with Eyes Open in Community-dwelling Elderly Women Reviewed

IWASAKI Masanori, YOSHIHARA Akihiro, MIYAZAKI Hideo

62 ( 3 ) 289 - 295 2012

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dental Health

The one-leg standing test has been widely practiced as an equilibrium function test in the elderly because of its simple evaluation method. Previous studies confirmed that those who cannot maintain a one-leg standing position with eyes open for 30 seconds had a significantly increased risk of falls. Falls in the elderly can cause fracture, gait disturbance, hospital admission, and death. Mean-while, the study results regarding oral function and physical strength in the elderly showed that the one-leg standing time and number of teeth present/occlusal support area are closely associated. A color-changeable chewing gum test for masticatory performance is a simple method that can evaluate a subject's masticatory performance in a short period of time. The results of this test show a significant correlation with the number of teeth present or occlusal support area. This study examined the association between masticatory performance using a color-changeable chewing gum and the one-leg standing time with eyes open in community-dwelling elderly women. The subjects were 138 women aged between 65 and 74 years who participated in the surveys conducted in 2009 and 2010, and consented to undergo a medical interview, body measurement, one-leg standing test with eyes open, and oral examination. Color-changeable chewing gum was used to measure the masticatory performance. The color of the gum after chewing for 2 minutes was assessed using a color chart, and the masticatory ability was evaluated using a 5-point rating scale (score of 1-5). Based on the scores, the subjects were divided into three groups (high performance group: 5 points; moderate performance group: 4 points; low performance group: 1-3 points). Denture wearers underwent tests with their dentures in. Logistic regression analyses were performed, with masticatory performance using a color-changeable chewing gum as the main variable, to estimate its influence on the ability to stand on one leg with eyes open for 30 seconds. Tested potential confounders included the number of teeth present, age, and motor function. A lower masticatory performance was significantly associated with the inability to stand on one leg with eyes open for 30 seconds (adjusted odds ratio [95% CI] = 2.34 [0.91-6.01] in moderate performance and 3.61 [1.14-11.4] in low performance groups). A decrease in the motor function was also significantly associated with the inability to stand on one leg with eyes open for 30 seconds (adjusted odds ratio [95%CI] = 5.00 [1.30-19.1]). The results indicated that there was a significant association between the masticatory performance using a color-changeable chewing gum and one-leg standing time with eyes open in community-dwelling elderly women.

DOI： 10.5834/jdh.62.3_289

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Association Between Glucan Synthesis by Streptococcus mutans and Caries Incidence in Schoolchildren Receiving a Fluoride Mouth Rinse

Umetsu, Hidehiro, Kaneko, Noboru, Yoshihara, Akihiro, Sakuma, Shihoko, Hanada, Nobuhiro, Miyazaki, Hideo

ORAL HEALTH & PREVENTIVE DENTISTRY 10 ( 2 ) 161 - 166 2012

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Association between Masticatory Performance and One-leg Standing Time with Eyes Open in Community-dwelling Elderly Women

IWASAKI Masanori, YOSHIHARA Akihiro, MIYAZAKI Hideo

J Dent Hlth 62 ( 3 ) 289 - 295 2012

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Oral Health

The one-leg standing test has been widely practiced as an equilibrium function test in the elderly because of its simple evaluation method. Previous studies confirmed that those who cannot maintain a one-leg standing position with eyes open for 30 seconds had a significantly increased risk of falls. Falls in the elderly can cause fracture, gait disturbance, hospital admission, and death. Mean-while, the study results regarding oral function and physical strength in the elderly showed that the one-leg standing time and number of teeth present/occlusal support area are closely associated. A color-changeable chewing gum test for masticatory performance is a simple method that can evaluate a subject's masticatory performance in a short period of time. The results of this test show a significant correlation with the number of teeth present or occlusal support area. This study examined the association between masticatory performance using a color-changeable chewing gum and the one-leg standing time with eyes open in community-dwelling elderly women. The subjects were 138 women aged between 65 and 74 years who participated in the surveys conducted in 2009 and 2010, and consented t

DOI： 10.5834/jdh.62.3_289

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The Relationship between Articulation Function Evaluated by Oral Diadochokinesis and Speech Mechanism Disorder Reviewed

62 ( 5 ) 445 - 453 2012

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DOI： 10.5834/jdh.62.5_445

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Relationship between root caries and cardiac dysrhythmia Reviewed

Masayuki Kaneko, Akihiro Yoshihara, Hideo Miyazaki

GERODONTOLOGY 28 ( 4 ) 289 - 295 2011.12

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DOI： 10.1111/j.1741-2358.2010.00367.x

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Relationship between root caries and cardiac dysrhythmia

Masayuki Kaneko, Akihiro Yoshihara, Hideo Miyazaki

GERODONTOLOGY 28 ( 4 ) 289 - 295 2011.12

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DOI： 10.1111/j.1741-2358.2010.00367.x

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Mineral content of calcium and magnesium in the serum and longitudinal periodontal progression in Japanese elderly smokers Reviewed

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 38 ( 11 ) 992 - 997 2011.11

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DOI： 10.1111/j.1600-051X.2011.01769.x

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Mineral content of calcium and magnesium in the serum and longitudinal periodontal progression in Japanese elderly smokers

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 38 ( 11 ) 992 - 997 2011.11

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DOI： 10.1111/j.1600-051X.2011.01769.x

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Physical activity and 5-year changes in physical performance tests and bone mineral density in postmenopausal women: The Yokogoshi Study Reviewed

Kaori Kitamura, Kazutoshi Nakamura, Ryosaku Kobayashi, Rieko Oshiki, Toshiko Saito, Mari Oyama, Shunsuke Takahashi, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

MATURITAS 70 ( 1 ) 80 - 84 2011.9

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DOI： 10.1016/j.maturitas.2011.06.014

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Physical activity and 5-year changes in physical performance tests and bone mineral density in postmenopausal women: The Yokogoshi Study

Kaori Kitamura, Kazutoshi Nakamura, Ryosaku Kobayashi, Rieko Oshiki, Toshiko Saito, Mari Oyama, Shunsuke Takahashi, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

MATURITAS 70 ( 1 ) 80 - 84 2011.9

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DOI： 10.1016/j.maturitas.2011.06.014

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縦断調査からみた歯列欠損形態と咀嚼能力の経年変化

佐藤直子, 野村修一, 昆はるか, 櫻井直樹, 葭原明弘, 宮崎秀夫, 河野正司

老年歯科医学 26 ( 2 ) 171 - 172 2011.9

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Relationships among bone turnover, renal function and periodontal disease in elderly Japanese Reviewed

A. Yoshihara, Y. Hayashi, H. Miyazaki

JOURNAL OF PERIODONTAL RESEARCH 46 ( 4 ) 491 - 496 2011.8

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DOI： 10.1111/j.1600-0765.2011.01365.x

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Dietary ratio of n-6 to n-3 polyunsaturated fatty acids and periodontal disease in community-based older Japanese: A 3-year follow-up study

Masanori Iwasaki, George W. Taylor, Paula Moynihan, Akihiro Yoshihara, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 85 ( 2 ) 107 - 112 2011.8

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DOI： 10.1016/j.plefa.2011.04.002

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Dietary ratio of n-6 to n-3 polyunsaturated fatty acids and periodontal disease in community-based older Japanese: A 3-year follow-up study Reviewed

Masanori Iwasaki, George W. Taylor, Paula Moynihan, Akihiro Yoshihara, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 85 ( 2 ) 107 - 112 2011.8

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DOI： 10.1016/j.plefa.2011.04.002

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Relationship between Saturated Fatty Acids and Periodontal Disease Reviewed

M. Iwasaki, M. C. Manz, P. Moynihan, A. Yoshihara, K. Muramatsu, R. Watanabe, H. Miyazaki

JOURNAL OF DENTAL RESEARCH 90 ( 7 ) 861 - 867 2011.7

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DOI： 10.1177/0022034511405384

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Relationship between bone fragility of the mandibular inferior cortex and tooth loss related to periodontal disease in older people Reviewed

A. Yoshihara, T. Deguchi, H. Miyazaki

COMMUNITY DENTAL HEALTH 28 ( 2 ) 165 - 169 2011.6

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DOI： 10.1922/CDH_2532Yoshihara05

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Relationships between the amount of saliva and medications in elderly individuals

Kana Ichikawa, Shihoko Sakuma, Akihiro Yoshihara, Hideo Miyazaki, Saori Funayama, Kayoko Ito, Atsuko Igarashi

GERODONTOLOGY 28 ( 2 ) 116 - 120 2011.6

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DOI： 10.1111/j.1741-2358.2009.00358.x

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Relationships between the amount of saliva and medications in elderly individuals Reviewed

Kana Ichikawa, Shihoko Sakuma, Akihiro Yoshihara, Hideo Miyazaki, Saori Funayama, Kayoko Ito, Atsuko Igarashi

GERODONTOLOGY 28 ( 2 ) 116 - 120 2011.6

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DOI： 10.1111/j.1741-2358.2009.00358.x

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Glomerular filtration rate and 10-year mortality in a 70-year-old community-dwelling Japanese population Reviewed

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

AGING CLINICAL AND EXPERIMENTAL RESEARCH 23 ( 3 ) 223 - 230 2011.6

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DOI： 10.3275/7207

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Glomerular filtration rate and 10-year mortality in a 70-year-old community-dwelling Japanese population

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

AGING CLINICAL AND EXPERIMENTAL RESEARCH 23 ( 3 ) 223 - 230 2011.6

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DOI： 10.3275/7207

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縦断調査からみた歯列欠損形態と咀嚼能力の経年変化

佐藤直子, 野村修一, 昆はるか, 桜井直樹, 河野正司, 葭原明弘, 宮崎秀夫

日本老年歯科医学会総会・学術大会プログラム・抄録集 22回 152 - 152 2011.6

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Influence of dental occlusion on physical fitness decline in a healthy Japanese elderly population

Naoko Okuyama, Takayuki Yamaga, Akihiro Yoshihara, Kaname Nohno, Yutaka Yoshitake, Yasuo Kimura, Mieko Shimada, Naoki Nakagawa, Mamoru Nishimuta, Masaharu Ohashi, Hideo Miyazaki

ARCHIVES OF GERONTOLOGY AND GERIATRICS 52 ( 2 ) 172 - 176 2011.3

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DOI： 10.1016/j.archger.2010.03.011

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特定健診対象者における歯周疾患スクリーニングテストとメタボリックシンドロームとの関連性 Reviewed

岩﨑正則, 葭原明弘, 宮﨑秀夫

日本口腔衛生学会雑誌 61 573 - 580 2011

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DOI： 10.5834/jdh.61.5_573

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Long-term caries preventive effects of a school-based Fluoride Mouth Rinse program in adulthood Reviewed

Y. Neko-Uwagawa, A. Yoshihara, H. Miyazaki

Open Dentistry Journal 5 ( 1 ) 24 - 28 2011

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DOI： 10.2174/1874210601105010024

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Economic evaluation of a school-based combined program with a targeted pit and fissure sealant and fluoride mouth rinse in Japan Reviewed

Y Neko-Uwagawa, A Yoshihara, H Miyazaki

The Open Dentistry Journal 5 24 - 28 2011

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成人期および高齢期における咀嚼回数と体格の関連 Reviewed

岩﨑正則, 葭原明弘, 宮﨑秀夫

日本口腔衛生学会雑誌 61 318 - 328 2011

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DOI： 10.5834/jdh.61.5_563

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用語委員会報告口腔衛生関連学術用語の統一に関する見解 Reviewed

千葉逸朗, 尾崎哲則, 加藤一夫, 日野出大輔, 平田幸夫, 葭原明弘

日本口腔衛生学会 61 563 - 572 2011

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Relationship between periodontal disease and bone metabolism in the elderly Invited

A Yoshihara

Journal of Dental Health 61 178 - 182 2011

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Longitudinal relationship between dietary omega-3 fatty acids and periodontal disease

Masanori Iwasaki, Akihiro Yoshihara, Paula Moynihan, Reiko Watanabe, George W. Taylor, Hideo Miyazaki

NUTRITION 26 ( 11-12 ) 1105 - 1109 2010.11

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DOI： 10.1016/j.nut.2009.09.010

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Longitudinal relationship between dietary omega-3 fatty acids and periodontal disease Reviewed

Masanori Iwasaki, Akihiro Yoshihara, Paula Moynihan, Reiko Watanabe, George W. Taylor, Hideo Miyazaki

NUTRITION 26 ( 11-12 ) 1105 - 1109 2010.11

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DOI： 10.1016/j.nut.2009.09.010

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Dietary omega-3 fatty acid may control periodontal disease Low dietary docosahexaenoic acid might be a significant risk factor of periodontal disease progression Reviewed

Masanori Iwasaki, Akihiro Yoshihara, Paula Moynihan, Reiko Watanabe, Hideo Miyazaki

AGRO FOOD INDUSTRY HI-TECH 21 ( 6 ) 34 - 37 2010.11

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フッ化物洗口の都道府県別にみた普及の推移国の政策が果たした役割の検討 Reviewed

田浦勝彦, 相田潤, 安藤雄一, 晴佐久悟, 田口千恵子, 木本一成, 葭原明弘, 筒井昭仁, 眞木吉信, 荒川浩久, 飯島洋一, 磯崎篤則, 小林清吾, 小関健由

口腔衛生学会雑誌 60 ( 5 ) 556 - 562 2010.10

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DOI： 10.5834/jdh.60.5_556

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飽和脂肪酸が歯周病の発症・進行に与える影響

岩崎正則, 葭原明弘, 村松芳多子, 渡邊令子, 宮崎秀夫

口腔衛生学会雑誌 60 ( 4 ) 388 - 388 2010.8

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Tooth-related risk factors for periodontal disease in community-dwelling elderly people

Toshinobu Hirotomi, Akihiro Yoshihara, Hiroshi Ogawa, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 37 ( 6 ) 494 - 500 2010.6

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DOI： 10.1111/j.1600-051X.2010.01565.x

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縦断調査から見た地域高齢者の咀嚼能力

佐藤直子, 野村修一, 昆はるか, 櫻井直樹, 河野正司, 葭原明弘, 宮崎秀夫

日本老年歯科医学会総会・学術大会プログラム・抄録集 21回 107 - 107 2010.6

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Relationship between the mandibular inferior cortex and bone stiffness in elderly Japanese people Reviewed

B. Kiswanjaya, A. Yoshihara, T. Deguchi, N. Hanada, H. Miyazaki

OSTEOPOROSIS INTERNATIONAL 21 ( 3 ) 433 - 438 2010.3

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DOI： 10.1007/s00198-009-0996-9

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A Quick Statistically Accurate Diagnosis for Caries Risk in the Elderly

Hidenobu Senpuku, Hideo Miyazaki, Saori Yoneda, Akihiro Yoshihara, Akio Tada

CLINICAL LABORATORY 56 ( 11-12 ) 505 - 512 2010

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高齢者の口腔乾燥感と神経症症状および服薬との関連 Reviewed

船山さおり, 伊藤加世子, 濃野要, 五十嵐敦子, 井上誠, 葭原明弘, 宮﨑秀夫

日本口腔衛生学会雑誌 60 ( 5 ) 575 - 583 2010

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DOI： 10.5834/jdh.60.5_575

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A study of oral health in Vientiane, Lao PDR Reviewed

M Kaneko, H Ogawa, A Yoshihara, N Murayama, S Ladparkdy, K Phommavongsa, B Boupha, H Miyazaki

The international Journal of Oral Health 6 1 - 7 2010

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The Effects of Medication and Psychological Well-being on Subjective Oral Dryness in the Elderly

FUNAYAMA Saori, ITO Kayoko, NOHNO Kaname, IGARASHI Atsuko, INOUE Makoto, YOSHIHARA Akihiro, MIYAZAKI Hideo

J Dent Hlth 60 ( 5 ) 575 - 583 2010

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Objective: One of the main causes of subjective oral dryness in the elderly is the side effects of medication. In addition, the elderly's tolerance to stress is low, and stress may induce many symptoms including mouth dryness. Thus, it is necessary to examine their psychological well-being. However, few reports have considered the relationship between subjective oral dryness and psychological well-being. Furthermore, few reports have examined subjective oral dryness, medication use, and psychological well-being simultaneously. The purpose of this study was to investigate the rate of subjective oral dryness and effects of psychological well-being and medication in the elderly. Methods: A questionnaire survey and interview concerning subjective oral dryness, medication use, and psychological symptoms were conducted involving 398 elderly aged 77-78 years old in Japan. The rates of the side effect of subjective oral dryness caused by medication and drug efficacy were investigated using the book 'Drugs in Japan'. The Japanese version of a general health questionnaire (GHQ 30), a self-entry type questionnaire, was used to evaluate psychological well-being. The elderly with scores greater

DOI： 10.5834/jdh.60.5_575

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高齢者における咀嚼回数と食品群別摂取量および栄養素等摂取量との関連 Reviewed

岩崎正則, 葭原明弘, 村松芳多子, 渡邊令子, 宮崎秀夫

日本口腔衛生学会雑誌 60 128 - 138 2010

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DOI： 10.5834/jdh.60.2_128

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Correlation between Oral Care and Fever in General Ward Patients Reviewed

Ryoko Hori, Naoko Takano, Akihiro Yoshihara, Hideo Miyazaki

Japanese Journal of Environmental Infections 25 ( 2 ) 85 - 90 2010

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DOI： 10.4058/jsei.25.85

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A Quick Statistically Accurate Diagnosis for Caries Risk in the Elderly Reviewed

Hidenobu Senpuku, Hideo Miyazaki, Saori Yoneda, Akihiro Yoshihara, Akio Tada

CLINICAL LABORATORY 56 ( 11-12 ) 505 - 512 2010

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小規模障害者施設における心身障害者のう蝕および歯周病の罹患状況に関する研究 Reviewed

杉浦貴美子, 葭原明弘, 藤山友紀, 岡田匠, 宮﨑秀夫

日本口腔衛生学会雑誌 60 112 - 118 2010

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DOI： 10.5834/jdh.60.2_112

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The Relationship between the Speed of Eating and Nutritional Intake of Japanese Aged 80 Years Old Based on Responses to a Brief-type Self-administered Diet History Questionnaire Reviewed

IWASAKI Masanori, YOSHIHARA Akihiro, MURAMATSU Kanako, WATANABE Reiko, MIYAZAKI Hideo

Journal of dental health 60 ( 1 ) 30 - 37 2010

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A brief-type self-administered diet history questionnaire (BDHQ) is a validated method of dietary assessment. This study investigated the relationship between the speed of eating, which is considered an eating behavior, and the estimated nutrient intake using the BDHQ in community-dwelling Japanese aged 80 years old. Three hundred and fifty-four participants (174 males and 180 females) aged 80 years old who participated in both dental examinations and BDHQ assessment conducted in 2008 were included in the analysis. The speed of eating was self-reported by giving a response chosen from five qualitative categories: 'very fast', 'relatively fast', 'medium', 'relatively slowly', and 'very slowly'. The five categories were classified into two categories for statistical analysis, that is, participants who answered 'very fast' and 'relatively fast' were defined as 'eating fast', while those who answered 'medium', 'relatively slowly', and 'very slowly' were defined as 'eating slowly'. The nutrient intake was calculated from the BDHQ using the ad-hoc program developed for nutrient calculation based on BDHQ responses. The estimated nutrient intake was compared between the two groups defined as eating 'fast' or 'slowly'. Furthermore, multivariable linear regression analysis was conducted using the speed of eating, gender, BMI, number of teeth, and masticatory function as independent variables to assess the influence on the estimated nutrient intake. The participants defined as eating 'fast' consumed significantly more zinc, copper, cryptoxanthin, and vitamin C than participants defined as eating 'slowly' (p=0.012, p=0.022, p=0.007, and p=0.049, respectively; Student's t-test). Moreover, the zinc, copper, cryptoxanthin, and vitamin C intakes of participants defined as eating 'fast' remained significantly higher than those of participants defined as eating 'slowly' after simultaneously adjusting for possible confounders (p=0.027, p=0.039, p=0.004, and p=0.043, respectively). The findings of this study suggest that Japanese people aged 80 years old who define themselves as eating fast consume higher levels of nutrients that are included in meat, fish, shellfish, vegetables, and fruits.

DOI： 10.5834/jdh.60.1_30

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Evaluation of Personalized Oral Health Program for Mothers Provided with Screening Examination at their Infants' Medical and Dental Check-ups Reviewed

YOSHIHARA Akihiro, KANEKO Noboru, SUGIMOTO Tomoko, SEIDA Yoshikazu, SATO Toru, MIYAZAKI Hideo

Journal of dental health 60 ( 1 ) 11 - 16 2010

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Dental examinations are often conducted in cities, towns, and villages as part of an oral health program for adults. However, in many places, a low percentage of subjects participate in these programs. This study evaluated the effects of a prevention program on periodontal disease focusing on personal education for adults, assessing whether or not the percentage of subjects who use interdental brushes or dental floss daily increase. Seventy-three mothers were surveyed in S city in Niigata Prefecture. Clinical examinations were performed for mothers who visited their local health centers while taking their children for their 1- or 2.5- year medical and dental check-ups. Subjects were divided into 2 groups: test group (n=29, mean age=32.7±5.1) and control group (n=44, mean age=30.2±5.2). For the test group, a chewing function test using chewing gum and a saliva bleeding test employing stimulated saliva as a screening examination, as well as personal education regarding dental care, were conducted by dental hygienists. The instruction was provided to improve the following two items: (1) the use of dental floss or interdental brushes, and (2) regular professional dental check-ups. We used a jaw model, booklets, and dental floss to support the personal instruction. For the control group, a dental examination using a probe and mirror was conducted, and tooth-brushing instructions were provided. Changes in oral health conditions and oral health behavior were evaluated over a 3-month period. The results showed that the rate of subjects who used dental floss or interdental brushes increased from 41.4% (baseline) to 62.1% (3 months) in the test group (20.7% change, P<0.001) compared with 34.1% (baseline) to 47.7% (3 months) in the control group (13.6% change, P<0.001). These results demonstrate that personal instruction with, a screening examination for mothers who bring their children for medical and dental check-ups may improve oral hygiene.

DOI： 10.5834/jdh.60.1_11

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Economic Evaluation of a School-based Combined Program with a Targeted Pit and Fissure Sealant and Fluoride Mouth Rinse in Japan.

Sakuma S, Yoshihara A, Miyazaki H, Kobayashi S

The open dentistry journal 4 230 - 6 2010

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DOI： 10.2174/1874210601004010230

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特定高齢者における口腔機能向上プログラムの効果 Reviewed

薄波清美, 髙野尚子, 葭原明弘, 宮﨑秀夫

新潟歯学会雑誌 40 33 - 37 2010

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Low calcium intake is associated with increased bone resorption in postmenopausal Japanese women: Yokogoshi Study Reviewed

Kazutoshi Nakamura, Toshiko Saito, Akihiro Yoshihara, Miki Ishikawa, Yasuo Tsuchiya, Rieko Oshiki, Ryosaku Kobayashi, Keiko Maruyama, Keiko Hyodo, Mitsue Nashimoto, Naoko Tsugawa, Toshio Okano, Mari Oyama, Masaharu Yamamoto

PUBLIC HEALTH NUTRITION 12 ( 12 ) 2366 - 2370 2009.12

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DOI： 10.1017/S1368980009005084

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Low calcium intake is associated with increased bone resorption in postmenopausal Japanese women: Yokogoshi Study

Kazutoshi Nakamura, Toshiko Saito, Akihiro Yoshihara, Miki Ishikawa, Yasuo Tsuchiya, Rieko Oshiki, Ryosaku Kobayashi, Keiko Maruyama, Keiko Hyodo, Mitsue Nashimoto, Naoko Tsugawa, Toshio Okano, Mari Oyama, Masaharu Yamamoto

PUBLIC HEALTH NUTRITION 12 ( 12 ) 2366 - 2370 2009.12

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DOI： 10.1017/S1368980009005084

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日本における集団応用でのフッ化物洗口に関する実態調査施設別、都道府県別の普及状況(2008) Reviewed

木本一成, 田浦勝彦, 田口千恵子, 相田潤, 晴佐久悟, 葭原明弘, 安藤雄一, 荒川浩久, 境脩

口腔衛生学会雑誌 59 ( 5 ) 586 - 595 2009.10

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DOI： 10.5834/jdh.59.5_586

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Long-term follow-up of the effects of a school-based caries preventive programme involving fluoride mouth rinse and targeted fissure sealant: Evaluation at 20 years old

Aya Nakamura, Shihoko Sakuma, Akihiro Yoshihara, Tomoya Deguchi, Minoru Yagi, Hideo Miyazaki

INTERNATIONAL DENTAL JOURNAL 59 ( 4 ) 215 - 221 2009.8

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DOI： 10.1922/IDJ_2233Sakuma07

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Long-term follow-up of the effects of a school-based caries preventive programme involving fluoride mouth rinse and targeted fissure sealant: Evaluation at 20 vears old Reviewed

Aya Nakamura, Shihoko Sakuma, Akihiro Yoshihara, Tomoya Deguchi, Minoru Yagi

International Dental Journal 59 ( 4 ) 215 - 221 2009.8

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DOI： 10.1922/IDJ-2233Sakuma07

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高齢者[79歳から80歳]における唾液量・服用薬剤・血液情報[生化学検査]との関連 Reviewed

市川加奈, 佐久間汐子, 葭原明弘, 宮崎秀夫, 五十嵐敦子

日本老年歯科医学会総会・学術大会プログラム・抄録集 20回 140 - 140 2009.6

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A longitudinal study of the relationship between diet intake and dental caries and periodontal disease in elderly Japanese subjects Reviewed

Yoshihara, Akihiro, Watanabe, Reiko, Hanada, Nobuhiro, Miyazaki, Hideo

GERODONTOLOGY 26 ( 2 ) 130 - 136 2009.6

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DOI： 10.1111/j.1741-2358.2008.00244.x

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A longitudinal study of the relationship between diet intake and dental caries and periodontal disease in elderly Japanese subjects.

Yoshihara A, Watanabe R, Hanada N, Miyazaki H

Gerodontology 26 ( 2 ) 130 - 6 2009.6

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DOI： 10.1111/j.1741-2358.2008.00244.x

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The Relationship Between Serum Lipids and Periodontitis in Elderly Non-Smokers

Aki Izumi, Akihiro Yoshihara, Toshinobu Hirotomi, Hideo Miyazaki

JOURNAL OF PERIODONTOLOGY 80 ( 5 ) 740 - 748 2009.5

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DOI： 10.1902/jop.2009.080584

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The Relationship Between Serum Lipids and Periodontitis in Elderly Non-Smokers Reviewed

Aki Izumi, Akihiro Yoshihara, Toshinobu Hirotomi, Hideo Miyazaki

JOURNAL OF PERIODONTOLOGY 80 ( 5 ) 740 - 748 2009.5

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DOI： 10.1902/jop.2009.080584

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Relation of bone turnover markers to periodontal disease and jaw bone morphology in elderly Japanese subjects Reviewed

A. Yoshihara, T. Deguchi, N. Hanada, H. Miyazaki

ORAL DISEASES 15 ( 2 ) 176 - 181 2009.3

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DOI： 10.1111/j.1601-0825.2008.01511.x

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Circulating TNF- α and oral health condition in elderly Japanese

Hideaki Hayashida, Toshiyuki Saito, Reiko Furugen, Noboru Yamaguchi, Akihiro Yoshihara, Hiroshi Ogawa, Hideo Miyazaki

Tumor Necrosis Factor 151 - 158 2009.1

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オーラルディアドコキネスの測定法に関する研究 Reviewed

伊藤加代子, 葭原明弘, 高野尚子, 石上和男, 清田義和, 井上誠, 北原稔, 宮﨑秀夫

老年歯学 24 48 - 54 2009.1

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DOI： 10.11259/jsg.24.48

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新潟市における口腔機能向上事業の結果分析 Reviewed

金子正幸, 葭原明弘, 伊藤加代子, 高野尚子, 藤山友紀, 宮﨑秀夫

口腔衛生会誌 59 26 - 33 2009.1

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地域在住高齢者に対する口腔機能向上事業の有効性 Reviewed

金子正幸, 葭原明弘, 伊藤加代子, 高野尚子, 藤山友紀, 宮崎秀夫

口腔衛生学会雑誌 59 ( 1 ) 26 - 33 2009.1

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DOI： 10.5834/jdh.59.1_26

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70歳地域在住高齢者の歯の喪失リスク要因に関する研究－５年間のコホート調査結果－ Reviewed

近藤隆子, 葭原明弘, 清田義和, 宮﨑秀夫

日本口腔衛生学会雑誌 59 198 - 206 2009

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DOI： 10.5834/jdh.59.3_198

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Physical Function Is Weakly Associated with Angiotensin-Converting Enzyme Gene I/D Polymorphism in Elderly Japanese Subjects Reviewed

A. Yoshihara, T. Tobina, T. Yamaga, M. Ayabe, Y. Yoshitake, Y. Kimura, M. Shimada, M. Nishimuta, N. Nakagawa, M. Ohashi, N. Hanada, H. Tanaka, A. Kiyonaga, H. Miyazaki

GERONTOLOGY 55 ( 4 ) 387 - 392 2009

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DOI： 10.1159/000222429

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オーラルディアドコキネスの測定法に関する研究 Reviewed

伊藤加代子, 葭原明弘, 高野尚子, 石上和男, 清田義和, 井上誠, 北原稔, 宮﨑秀夫

老年歯科医学会雑誌 24 48 - 54 2009

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DOI： 10.11259/jsg.24.48

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Factors Affecting the Satisfaction of Elderly Denture Wearers Reviewed

KON Haruka, SATOH Naoko, NOMURA Shuichi, SAKURAI Naoki, TANAKA Mikako, HOSOGAI Akiko, YAMADA Kazuho, KINJOH Atsushi, KAI Asako, YAMASHITA Emi, KANEKO Atsuro, MAGARA Zin, KOBAYASHI Hiroshi, MIYAZAKI Hideo, YOSHIHARA Akihiro, KOHNO Shoji

Annals of Japan Prosthodontic Society 1 ( 4 ) 361 - 369 2009

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Purpose: This study aimed to define the relationship between satisfaction of wearing denture and three factors ("easy to chew", "retention in chewing", "absence of pain"), as well as the missing teeth pattern with Miyachi classification, the chewing ability. Methods: A total of 256 subjects (born in 1927) living in Niigata city, Japan who had answered a questionnaire survey in 2007 on the relationship between oral health and health status were selected for this study. Satisfaction with dentures and three factors ("easy to chew", "retention in chewing", and "absence of pain") were evaluated with the VAS score. This study also investigated grouping the pattern of missing teeth based on the Miyachi classification. In addition, a questionnaire was conducted to investigate whether the elderly people could chew around 15 different food items or not. Result: It was clearly shown that satisfaction with dentures was correlated with the three points of chewing easily, stability, and pain-free among elderly people. However, none of the three points showed a far stronger correlation than the others. The results also showed that there was no relation between the missing teeth pattern classified with the Miyachi classification and satisfaction with dentures. The results of the questionnaire revealed that the number of food items taken by the elderly people was significantly lower in the group not satisfied with dentures than the other groups (Excellent, good, poorly satisfaction group). Conclusion: It was confirmed that chewing easily, stability and pain-free enhance satisfaction with dentures. However, satisfaction with dentures was not ascribed to the pattern of missing teeth; accordingly, we consider that we can keep elderly people satisfied by fabricating good dentures and performing appropriate adjustments regardless of difficult patterns of missing teeth.

DOI： 10.2186/ajps.1.361

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Association between serum calcium and periodontal disease progression in non-institutionalized elderly Reviewed

Najith Amarasena, Akihiro Yoshihara, Toshinobu Hirotomi, Naoko Takano, Hideo Miyazaki

GERODONTOLOGY 25 ( 4 ) 245 - 250 2008.12

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DOI： 10.1111/j.1741-2358.2007.00211.x

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Association between serum calcium and periodontal disease progression in non-institutionalized elderly

Najith Amarasena, Akihiro Yoshihara, Toshinobu Hirotomi, Naoko Takano, Hideo Miyazaki

GERODONTOLOGY 25 ( 4 ) 245 - 250 2008.12

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DOI： 10.1111/j.1741-2358.2007.00211.x

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Salivary spinability and periodontal disease progression in an elderly population Reviewed

T. Hirotomi, A. Yoshihara, H. Ogawa, K. Ito, A. Igarashi, H. Miyazaki

ARCHIVES OF ORAL BIOLOGY 53 ( 11 ) 1071 - 1076 2008.11

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DOI： 10.1016/j.archoralbio.2008.05.009

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Role of Activated Natural Killer Cells in Oral Diseases

Yuji Kamoda, Hiroshi Uematsu, Akihiro Yoshihara, Hideo Miyazaki, Hidenobu Senpuku

JAPANESE JOURNAL OF INFECTIOUS DISEASES 61 ( 6 ) 469 - 474 2008.11

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The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese Reviewed

R. Furugen, H. Hayashida, N. Yamaguchi, A. Yoshihara, H. Ogawa, H. Miyazaki, T. Saito

JOURNAL OF PERIODONTAL RESEARCH 43 ( 5 ) 556 - 562 2008.10

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DOI： 10.1111/j.1600-0765.2008.01085.x

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Relationship between mandibular inferior cortex and general bone metabolism in older adults Reviewed

T. Deguchi, A. Yoshihara, N. Hanada, H. Miyazaki

OSTEOPOROSIS INTERNATIONAL 19 ( 7 ) 935 - 940 2008.7

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DOI： 10.1007/s00198-007-0526-6

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Longitudinal study on the relationship between serum albumin and periodontal disease

Masanori Iwasaki, Akihiro Yoshihara, Toshinobu Hirotomi, Hiroshi Ogawa, Nobuhiro Hanada, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 35 ( 4 ) 291 - 296 2008.4

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DOI： 10.1111/j.1600-051X.2008.01215.x

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Longitudinal study on the relationship between serum albumin and periodontal disease Reviewed

Masanori Iwasaki, Akihiro Yoshihara, Toshinobu Hirotomi, Hiroshi Ogawa, Nobuhiro Hanada, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 35 ( 4 ) 291 - 296 2008.4

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DOI： 10.1111/j.1600-051X.2008.01215.x

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Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study Reviewed

Kazutoshi Nakamura, Naoko Tsugawa, Toshiko Saito, Miki Ishikawa, Yasuo Tsuchiya, Keiko Maruyama, Rieko Oshiki, Ryosaku Kobayashi, Mitsue Nashimoto, Akihiro Yoshihara, Reo Ozaki, Toshio Okano, Masaharu Yamamoto

BONE 42 ( 2 ) 271 - 277 2008.2

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DOI： 10.1016/j.bone.2007.09.056

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Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study

Kazutoshi Nakamura, Naoko Tsugawa, Toshiko Saito, Miki Ishikawa, Yasuo Tsuchiya, Keiko Maruyama, Rieko Oshiki, Ryosaku Kobayashi, Mitsue Nashimoto, Akihiro Yoshihara, Reo Ozaki, Toshio Okano, Masaharu Yamamoto

BONE 42 ( 2 ) 271 - 277 2008.2

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DOI： 10.1016/j.bone.2007.09.056

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A Health Survey of Mothers Present at Their Infants Health Examination : Are the Subjects Representative of Those in Nationwide Surveys? Reviewed

ANDO Yuichi, NAKAGAKI Haruo, MIYAZAKI Hideo, YOSHIHARA Akihiro, ARAKAWA Hirohisa, IIJIMA Youichi, KAWASAKI Koji, IGO Junko, SUGIMOTO Tomoko, WATANABE Kouko, SHIGEMASA Akihiko, TORIYAMA Yoshinori, TAGUCHI Nobuhiro

JOURNAL OF DENTAL HEALTH 58 ( 2 ) 95 - 105 2008.1

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An oral health survey of mothers who were present at dental examinations for their infants was conducted in four selected prefectures in Japan. The aim of this article was to assess the representativeness of the sample of this survey at different regional levels. The study areas were 33 municipalities selected using a stratified random sampling technique from each prefecture. From November 2005 to March 2006, we conducted oral examinations and questionnaire surveys at 138 sites. The oral examination methodology was the same as that for the national survey of dental diseases in 2005. The questionnaire survey consisted of subjective oral symptoms, knowledge and behavior regarding oral health, lifestyle habits, etc., and most questions were derived from existing national surveys. The number of subjects was 2,786 in oral examinations (response rate: 65%) and 3,301 for the questionnaire survey (response rate: 77%). The average age of the subjects was 31.4 years old. No significant difference was noted regarding the prevalence of dental caries and periodontal disease. The percentages of persons with untreated carious and missing teeth were lower in this survey. Regarding the questionnaire survey, most items did not show a significant difference from existing national surveys. However, the subjects in this survey followed a healthier lifestyle and undertook earlier dental visits. A few survey items were correlated with the response rate in each municipality. Although the survey items which showed significant differences from existing national surveys seemed to be affected by the characteristics of the selected prefectures and the subjects who were mothers of infants, the representativeness of the sample of this survey was considerably high. Therefore, this survey was considered to be an useful nationwide data source in Japan.

DOI： 10.5834/jdh.58.2_95

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The Relationship between Oral Status and General Health in Subjects Older than 65 According to Selected Items Reviewed

YOSHIHARA Akihiro, TAKANO Naoko, MIYAZAKI Hideo

Journal of dental health 58 ( 1 ) 9 - 15 2008.1

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Recently, the need for preventive care for frail elderly subjects has been recognized. This study aimed to obtain information about the relationship between the oral status and general health in subjects older than 65 years according to selected items related to the frail elderly. We selected 852 subjects older than 65 years who participated in general health examinations. We conducted personal interviews to obtain information regarding habitual function, physical function, nutritional status, social withdrawal, dementia, and depression in addition to the oral status such as chewing function, feelings of suffocation while eating, and dry mouth. We counted the pertinent number of items for habitual function, physical function, nutrition status, social withdrawl, dementia, and depression. We compared the average number of items with oral function, including chewing ability, feelings of suffocation while eating, and dry mouth. The mean number of items for the disorders was higher in the elderly with the oral disorders assessed. In particular, there was a significant difference in the mean number of pertinent items related to dementia and depression between subjects with compared to those without oral disorders. These findings indicate the presence of a significant relationship between the oral status and general health conditions in frail elderly subjects. Preventive activities to maintain a good general status in frail elderly subjects should focus on improving oral function.

DOI： 10.5834/jdh.58.1_9

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Role of activated natural killer cells in oral diseases Reviewed

Yuji Kamoda, Hiroshi Uematsu, Akihiro Yoshihara, Hideo Miyazaki, Hidenobu Senpuku

Japanese Journal of Infectious Diseases 61 ( 6 ) 469 - 474 2008

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高齢者集団におけるCPIとアタッチメントロス評価法(WHO)の有用性および歯周健康状態に関する5年間の縦断研究 Reviewed

白根和明, 小川祐司, 廣冨敏伸, 高野尚子, 山賀孝之, 金子昇, 佐久間汐子, 葭原明弘, 宮秀夫

口腔衛生会誌 57 28 - 35 2007.12

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DOI： 10.5834/jdh.57.1_28

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Longitudinal relationship between root caries and serum albumin Reviewed

A. Yoshihara, N. Takano, T. Hirotomi, H. Ogawa, N. Hanada, H. Miyazaki

Journal of Dental Research 86 ( 11 ) 1115 - 1119 2007.11

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DOI： 10.1177/154405910708601118

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Serum markers of chronic dehydration are associated with saliva spinability Reviewed

A. Yoshihara, T. Hirotomi, N. Takano, T. Kondo, N. Hanada, H. Miyazaki

JOURNAL OF ORAL REHABILITATION 34 ( 10 ) 733 - 738 2007.10

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DOI： 10.1111/j.1365-2842.2007.01732.x

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Renal function and periodontal disease in elderly Japanese

Yoshihara, Akihiro, Deguchi, Tomoya, Hanada, Nobuhiro, Miyazaki, Hideo

JOURNAL OF PERIODONTOLOGY 78 ( 7 ) 1241 - 1248 2007.7

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DOI： 10.1902/jop.2007.070025

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Renal function and periodontal disease in elderly Japanese Reviewed

Yoshihara, Akihiro, Deguchi, Tomoya, Hanada, Nobuhiro, Miyazaki, Hideo

JOURNAL OF PERIODONTOLOGY 78 ( 7 ) 1241 - 1248 2007.7

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DOI： 10.1902/jop.2007.070025

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Relationships of anti-PAc (361-386) peptide salivary IgA antibody, eosinophils and basophils with periodontal status in the elderly Reviewed

Hidenobu Senpuku, Akio Tada, Ryoma Nakao, Hideo Yonezawa, Saori Yoneda, Akihiro Yoshihara, Hideo Miyazaki

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 49 ( 1 ) 84 - 90 2007.2

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DOI： 10.1111/j.1574-695X.2006.00193.x

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Relationships of anti-PAc (361-386) peptide salivary IgA antibody, eosinophils and basophils with periodontal status in the elderly

Hidenobu Senpuku, Akio Tada, Ryoma Nakao, Hideo Yonezawa, Saori Yoneda, Akihiro Yoshihara, Hideo Miyazaki

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 49 ( 1 ) 84 - 90 2007.2

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DOI： 10.1111/j.1574-695X.2006.00193.x

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Changes in electrical resistance of sound fissure enamel in first molars for 66 months from eruption Reviewed

S. Kataoka, S. Sakuma, J. Wang, A. Yoshihara, H. Miyazaki

CARIES RESEARCH 41 ( 2 ) 161 - 164 2007

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DOI： 10.1159/000098051

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Relationship of cariogenic bacteria levels with periodontal status and root surface caries in elderly Japanese. International journal

Saotome Y, Tada A, Hanada N, Yoshihara A, Uematsu H, Miyazaki H, Senpuku H

Gerodontology 23 ( 4 ) 219 - 25 2006.12

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OBJECTIVE: The relationship of the levels of cariogenic bacterial species with periodontal status and decayed root surfaces was investigated in elderly Japanese subjects. METHODS: Three hundred and sixty-eight individuals (each 75 years old) were examined for periodontal status (pocket depth, attachment loss), root surface caries and salivary levels of mutans streptococci (MS) and lactobacilli (LB). RESULTS: Values >4 mm of attachment loss (rAL4) and for average attachment loss (aAL) of sites measured were significantly higher in subjects with LB than those without. Multiple regression analysis also showed a correlation between aAL and rAL4 values with the presence of LB (aAL p = 0.003; rAL4 p = 0.002). Further, multiple regression analysis of interacting factors regarding decayed root surfaces showed that LB carriers had a greater incidence of decayed root surface caries (p = 0.003), while MS and LB levels were correlated to the number of decayed root surfaces (LB p = 0.010; MS p = 0.026). CONCLUSION: Our results indicate that considerable attachment loss elevates the possibility of having LB, thus increasing the risk of root surface caries. It was also found that LB and MS measurements may be useful indicators of decayed root surfaces in elderly individuals with attachment loss.

DOI： 10.1111/j.1741-2358.2006.00127.x

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The carriage of Candida species on the dorsal surface of the tongue: the correlation with the dental, periodontal and prosthetic status in elderly subjects Reviewed

Jing Wang, Tomoko Ohshima, Utako Yasunari, Satoko Namikoshi, Akihiro Yoshihara, Hideo Miyazaki, Nobuko Maeda

Gerodontology 23 157 - 163 2006.12

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DOI： 10.1111/j.1741-2358.2006.00130.x

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Relationship of cariogenic bacteria levels with periodontal status and root surface caries in elderly Japanese Reviewed International journal

Saotome Y, Tada A, Hanada N, Yoshihara A, Uematsu H, Miyazaki H, Senpuku H

Gerodontology 23 ( 4 ) 219 - 225 2006.12

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OBJECTIVE: The relationship of the levels of cariogenic bacterial species with periodontal status and decayed root surfaces was investigated in elderly Japanese subjects. METHODS: Three hundred and sixty-eight individuals (each 75 years old) were examined for periodontal status (pocket depth, attachment loss), root surface caries and salivary levels of mutans streptococci (MS) and lactobacilli (LB). RESULTS: Values >4 mm of attachment loss (rAL4) and for average attachment loss (aAL) of sites measured were significantly higher in subjects with LB than those without. Multiple regression analysis also showed a correlation between aAL and rAL4 values with the presence of LB (aAL p = 0.003; rAL4 p = 0.002). Further, multiple regression analysis of interacting factors regarding decayed root surfaces showed that LB carriers had a greater incidence of decayed root surface caries (p = 0.003), while MS and LB levels were correlated to the number of decayed root surfaces (LB p = 0.010; MS p = 0.026). CONCLUSION: Our results indicate that considerable attachment loss elevates the possibility of having LB, thus increasing the risk of root surface caries. It was also found that LB and MS measurements may be useful indicators of decayed root surfaces in elderly individuals with attachment loss.

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Preliminary study on the effect of oral care on recovery from surgery in elderly patients Reviewed

M. Sato, A. Yoshihara, H. Miyazaki

JOURNAL OF ORAL REHABILITATION 33 ( 11 ) 820 - 826 2006.11

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DOI： 10.1111/j.1365-2842.2006.01634.x

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A preliminary study on the relationship between stimulated saliva and periodontal conditions in community-dwelling elderly people Reviewed

T. Hirotomi, A. Yoshihara, H. Ogawa, K. Ito, A. Igarashi, H. Miyazaki

JOURNAL OF DENTISTRY 34 ( 9 ) 692 - 698 2006.10

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DOI： 10.1016/j.jdent.2006.01.001

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The carriage of Candida species on the dorsal surface of the tongue: the correlation with the dental, periodontal and prosthetic status in elderly subjects.

Wang J, Ohshima T, Yasunari U, Namikoshi S, Yoshihara A, Miyazaki H, Maeda N

Gerodontology 23 ( 3 ) 157 - 63 2006.9

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DOI： 10.1111/j.1741-2358.2006.00130.x

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フッ化物洗口プログラムをベースとした選択的シーラント応用の20歳成人におけるう蝕予防効果

中村文, 佐久間汐子, 葭原明弘, 八木稔, 出口知也, 宮崎秀夫

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 56 ( 4 ) 520 - 520 2006.8

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Association between commensal bacteria and opportunistic pathogens in the dental plaque of elderly individuals Reviewed

A Tada, H Senpuku, Y Motozawa, A Yoshihara, N Hanada, H Tanzawa

CLINICAL MICROBIOLOGY AND INFECTION 12 ( 8 ) 776 - 781 2006.8

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DOI： 10.1111/j.1469-0691.2006.01497.x

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Association between serum albumin and periodontal disease in community-dwelling elderly Reviewed

H Ogawa, A Yoshihara, N Amarasena, T Hirotomi, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 33 ( 5 ) 312 - 316 2006.5

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DOI： 10.1111/j.1600-051X.2005.00901.x

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Association between serum albumin and periodontal disease in community-dwelling elderly

H Ogawa, A Yoshihara, N Amarasena, T Hirotomi, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 33 ( 5 ) 312 - 316 2006.5

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介護認定申請者における要介護度別歯科疾患の実態および歯科的治療ニーズに関する研究 Reviewed

鈴木昭, 河野正司, 野村修一, 伊藤加代子, 豊里晃, 田巻元子, 八木稔, 葭原明弘, 大内章嗣

新潟歯学会雑誌 35 ( 2 ) 209 - 214 2006.1

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介護認定者の歯科疾患の実態と歯科的治療ニーズを把握・評価するため,要介護度を踏まえた検討を行った.対象は新潟県内の同一保険医療福祉圏内の7市町村に在住し,2002年10月から12月の間に介護認定申請をした368名(平均年齢81歳)で,調査結果を分析し,以下の結論を得た.1)平均残存歯数と要介護度には相関関係はない,2)要介護度が上がると要抜去歯が有意に増加する傾向がある,3)歯科的治療ニーズ患者割合(要歯科治療・要専門的口腔ケアは89.4%),4)要介護状態になってから歯科を受診した患者割合は35.3%.以上より,歯科治療の必要性と実際の受診状況には大きな隔たりがあることが分かった

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Influence of a fluoride mouthrinse on mutans streptococci in schoolchildren Reviewed

Noboru Kaneko, Akihiro Yoshihara, Hirohisa Ida, Yoshiaki Nomura, Susumu Imai, Toshiki Nisizawa, Shihoko Sakuma, Nobuhiro Hanada, Hideo Miyazaki

CARIES RESEARCH 40 ( 6 ) 501 - 507 2006

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Influence of a fluoride mouthrinse on mutans streptococci in schoolchildren

Noboru Kaneko, Akihiro Yoshihara, Hirohisa Ida, Yoshiaki Nomura, Susumu Imai, Toshiki Nisizawa, Shihoko Sakuma, Nobuhiro Hanada, Hideo Miyazaki

CARIES RESEARCH 40 ( 6 ) 501 - 507 2006

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DOI： 10.1159/000095649

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義歯の装着と咬合力および噛める食品との関係 Reviewed

岩舩素子, 五十嵐直子, 河野正司, 清田義和, 葭原明弘, 宮秀夫

新潟歯学会誌 34 ( 2 ) 213 - 218 2005.12

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The relationship between dietary intake and the number of teeth in elderly Japanese subjects Reviewed

Akihiro Yoshihara, Reiko Watanabe, Mamoru Nishimuta, Nobuhiro Hanada, Hideo Miyazaki

Gerodontology 22 211 - 218 2005.12

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National Survey on the School-based Fluoride Mouthrinsing Program in Japan : Proposition Regarding Intermediate Assessment of Healthy Japan 21 in 2005 Reviewed

KIMOTO Kazunari, HARESAKU Satoru, TAURA Katsuhiko, SHIMURA Masayo, FUJINO Etsuo, YAMAMOTO Takeo, YOSHIHARA Akihiro, ISOZAKI Atsunori, ARAKAWA Hirohisa, KOBAYASHI Seigo, SAKAI Osamu

JOURNAL OF DENTAL HEALTH 55 ( 3 ) 199 - 203 2005.12

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The purpose of this investigation is to clarify the spread of the school-based fluoride mouthrinsing program over the past twenty years throughout Japan. Data were collected by questionnaire surveys regarding the schools and children participating in the program, frequency of rinsing, mouthrinsing agent used, fluoride concentration of the rinsing solution and financial support for the program. Questionnaires were sent to the key persons and dentists of the non-profit Japanese Conference on the Promotion of the Use of Fluoride in Caries Prevention (NPO-JPUF) by mail or e-mail every two years. Of the 47 prefectures in Japan, the fluoride mouthrinsing program started in a single prefecture in 1970, and spread to 32 by 1992 and to 45 by 2004. In 2004, the total numbers of schools and individuals participating in the program were 3,923 and 396,702, respectively. Although the numbers of schools and children participating in the program are increasing, they remain modest. In 2010, the numbers of schools and individuals participating in the school-based fluoride mouthrinsing program in Japan is estimated to be 8,782 and 896,916, respectively. We propose that the school-based fluoride mouthrinsing program, an important item with regarding caries prevention in Japanese children, should be included in Healthy Japan 21 at the intermediate assessment in 2005.

DOI： 10.5834/jdh.55.3_199

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公診連携を目指した8020育成事業の評価 Reviewed

葭原明弘, 片岡照二郎, 濃野要, 峯田和彦, 高徳幸男, 河内博, 片山修, 清田義和, 石上和男, 宮秀夫

口腔衛生会誌 55 113 - 117 2005.12

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DOI： 10.5834/jdh.55.2_113

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The relationship between dietary intake and the number of teeth in elderly Japanese subjects.

Yoshihara A, Watanabe R, Nishimuta M, Hanada N, Miyazaki H

Gerodontology 22 ( 4 ) 211 - 8 2005.12

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介護認定申請者における要介護度別歯科疾患の実態および歯科的治療ニーズに関する研究

鈴木昭, 河野正司, 野村修一, 伊藤加代子, 豊里晃, 田巻元子, 八木稔, 葭原明弘, 大内章嗣

新潟歯学会誌 35 ( 2 ) 25 - 30 2005.12

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Relationship between bleeding on probing and periodontal disease progression in community-dwelling older adults Reviewed

A. Rahardjo, A. Yoshihara, N. Amarasena, H. Ogawa, K. Nakashima, H. Miyazaki

Journal of Clinical Periodontology 32 ( 11 ) 1129 - 1133 2005.11

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DOI： 10.1111/j.1600-051X.2005.00834.x

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The relationship between bone mineral density and the number of remaining teeth in community-dwelling older adults Reviewed

A. Yoshihara, Y. Seida, N. Hanada, K. Nakashima, H. Miyazaki

Journal of Oral Rehabilitation 32 ( 10 ) 735 - 740 2005.10

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DOI： 10.1111/j.1365-2842.2005.01491.x

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Periodontal conditions in an elderly Japanese population influenced by smoking status and serum immunoglobulin G2 levels Reviewed

Keisuke Nakashima, Takao Kobayashi, Akihiro Yoshihara, Jun Fujiwara, Hideo Miyazaki, Yusuke Kowashi

Journal of Periodontology 76 ( 4 ) 582 - 589 2005.4

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DOI： 10.1902/jop.2005.76.4.582

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Periodontal conditions in an elderly Japanese population influenced by smoking status and serum immunoglobulin G2 levels

K Nakashima, T Kobayashi, A Yoshihara, J Fujiwara, H Miyazaki, Y Kowashi

JOURNAL OF PERIODONTOLOGY 76 ( 4 ) 582 - 589 2005.4

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FcγRIIIb genotypes and smoking in periodontal disease progression among community-dwelling older adults in Japan Reviewed

Akihiro Yoshihara, Noriko Sugita, Kouji Yamamoto, Tetsuo Kobayashi, Toshinobu Hirotomi, Hiroshi Ogawa, Hideo Miyazaki, Hiromasa Yoshie

Journal of Periodontology 76 ( 2 ) 250 - 255 2005.2

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DOI： 10.1902/jop.2005.76.2.250

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Fc gamma RIIIb genotypes and smoking in periodontal disease progression among community-dwelling older adults in Japan

A Yoshihara, N Sugita, K Yamamoto, T Kobayashi, T Hirotomi, H Ogawa, H Miyazaki, H Yoshie

JOURNAL OF PERIODONTOLOGY 76 ( 2 ) 250 - 255 2005.2

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DOI： 10.1902/jop.2005.76.2.250

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Serum vitamin C-periodontal relationship in community-dwelling elderly Japanese Reviewed

N Amarasena, H Ogawa, A Yoshihara, N Hanada, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 32 ( 1 ) 93 - 97 2005.1

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DOI： 10.1111/j.1600-051X.2004.00643.x

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Reliability and Validity of Global Ratings for Competency Assessment : An Analysis of and OSCE at Niigata University Faculty of Dentistry

OKIJI Takashi, FUKUSHIMA Masayoshi, YOSHIBA Kunihiko, KOBAYASHI Hiroshi, YOSHIHARA Akihiro, HOSHINA Hideyuki, TOMIZAWA Mieko, TAKAGI Ritsuo, MAEDA Takeyasu, YAMADA Yoshiaki

20 ( 1 ) 135 - 141 2004.12

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The long term effect of fluoride mouthrinse on changes in salivary levels of mutans streptococci in school children Reviewed

Akihiro Yoshihara, Shihoko Sakuma, Jing Wang, Hideo Miyazaki

Journal of Dental Health 54 233 - 240 2004.12

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DOI： 10.5834/jdh.54.3_233

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歯学教育プログラムへのPBL教育の導入南カリフォルニア大学歯学部における実態調査 Reviewed

安島久雄, 小野和宏, 前田健康, 永田昌毅, 高木律男, 山田好秋, 興地隆史, 魚島勝美, 葭原明弘, 花田晃治

日本歯科医学教育学会雑誌 Vol20(1) ( 1 ) 166 - 173 2004.12

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2001年12月に新潟大学の教員6名が南カリフォルニア大学歯学部を訪れ,米国人学生とともにPBL(問題解決型学習)教育を1週間体験した.また,PBLの概念,教科課程編成法,教材の作成法,評価方法などについて資料収集を行った.その結果,PLBでは問題への解答よりも学習者中心の問題解決過程を通じた理解の育成が重視されること,教員の役割は知識の伝授ではなくグループの作業プロセスを支援して学習目標への到達を促すものであることなどが確認された

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客観的臨床能力試験(OSCE)における概略評定の信頼性と妥当性平成15年度新潟大学歯学部OSCEの解析 Reviewed

興地隆史, 福島正義, 吉羽邦彦, 小林博, 葭原明弘, 星名秀行, 富沢美恵子, 高木律男, 前田健康, 山田好秋

日本歯科医学教育学会雑誌 Vol20(1) 135 - 141 2004.12

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The Relationship between Appetite and Quality of Life in Community-dwelling Older Adults Reviewed

YOSHIHARA Akihiro, SEIDA Yoshikazu, KATAOKA Shojiro, HANADA Nobuhiro, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 54 ( 3 ) 241 - 248 2004.12

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There are many elderly people who enjoy meals in their daily life. The purpose of this study was to evaluate the relationship between appetite and quality of life, controlling the known confounding factors. In this study, 600 subjects aged 70 years were included. In order to integrate quality of life, we used a face scale which has five face figures considered appropriate for a five-stage evaluation. A questionnaire survey was conducted to evaluate appetite. In addition, we obtained data on physical factors, healthy actions, social factors and oral symptoms. The comparison of the appetite, score of oral symptoms and other general factors between two groups divided according to the face scale score was investigated by multiple logistic regression analysis. We selected two kinds of dependent variables according to each face scale score (models 1 and 2). Appetite, total score of oral symptoms, Tokyo Metropolitan Institute of Gerontology index (TMIG index), amount of sleep and gender as independent variables were selected in both models. In model 1, appetite (Odds ratio : 2.77, p<0.05), total score of oral symptoms (Odds ratio : 1.25, p<0.05) , TMIG index (Odds ratio : 1.25, p<0.0l) were significant. On the other hand, in model 2, appetite (Odds ratio : 3.23, p<0.00l), TMIG index (Odds ratio : 1.24, p< 0.001) and amount of sleep (Odds ratio : 1.72,p<0.0l) were significant. Appetite was associated significantly with the face scale in both models 1 and 2, and the total score of oral symptoms was associated with the face scale in model 1. This study suggests that there was a significant relationship between appetite and quality of life in community-dwelling older adults, and a recovery of oral symptoms was necessary for improvement in the quality of life.

DOI： 10.5834/jdh.54.3_241

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Investigation on reproducibility of the term for classification of occlusion Reviewed

AOTO Seiji, FUKAMACHI Hiroomi, YOSHIHARA Akihiro, SAITO Isao

63 ( 2 ) 95 - 99 2004.12

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The purpose of this study was to evaluate the clinical availability of classification of occlusion proposed in "Classification of Occlusion in Clinical Orthodontics" published by Yogosawa Society of Orthodontists in 2000. Four orthodontists categorized study casts of one hundred orthodontic patients according to this classification of occlusion. The procedure was repeated two months later to assess intra-examiner agreement. Weighted kappa (κ_w) for intra- and inter-examiner agreement were calculated. An interpretation of κ_w was made on the basis of sensitivity and specificity by Landis and Altman. κ_w for intra-examiner agreement showed a value of 0.67 on an average, which implies substantial agreement. Both an initial and the second κ_w for inter-examiner agreement were more than O . 62 on average, indicating reliable and substantial agreement. Repeatability among four examiners was more dependent on familiarity with this term rather than on clinical experiences. With respect to repeatability among various types of malocclusion, "protruding upper bite" and "protruding lower bite" showed substantial agreement while "deep bite" and "diverted bite" indicated moderate agreement. (Orthod Waves-Jpn Ed 63(2) : 95-99, 2004)

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Association between Serum IgG Subclass Levels and Periodontal Status in an Elderly Japanese Population Reviewed

KOBAYASHI Takao, NAKASHIMA Keisuke, YOSHIHARA Akihiro, MIYAZAKI Hideo, KOWASHI Yusuke

JOURNAL OF THE JAPANESE ORGANISATION FOR RESEARCH OF PERIODONTOLOGY 46 ( 1 ) 31 - 38 2004.12

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Previous reports suggested that the association between serum IgG subclass levels and periodontal status is influenced by genetic and environmental factors, such as race and smoking. Japanese population living in the same area may be appropriate for evaluating this association due to similar racial and environmental factors. The present cross-sectional investigation studied this association in an elderly population of 451 subjects aged, 71 years residing in Niigata, Japan. Smokers and edentulous individuals were excluded. Dentulous nonsmokers were classified into 2 groups based on the number of teeth : those with fewen than 20 teeth and those with 20 or more teeth. The percentage of sites with PAL≥4mm and serum IgG 1 levels was significantly higher in subjects with fewer than 20 teeth. A significant negative correlation was observed between the number of teeth and IgG 1 subclass levels. This data indicates that higher levels of serum IgG 1 are associated with reduced numbers of teeth in a Japanese elderly population. Longitudinal investigation is necessary to clarify the reason for this in periodontitis-susceptible individuals.

DOI： 10.2329/perio.46.31

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A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults

A Yoshihara, Y Seida, N Hanada, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 31 ( 8 ) 680 - 684 2004.8

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DOI： 10.1111/j.1600-051X.2004.00548.x

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A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults Reviewed

A Yoshihara, Y Seida, N Hanada, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 31 ( 8 ) 680 - 684 2004.8

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DOI： 10.1111/j.1600-051X.2004.00548.x

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The Effect of Chewing Ability on the Dietary Intake of Healthy Elderly People Reviewed

KANMORI Hideki, YOSHIHARA Akihiro, ANDO Yuichi, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 53 ( 1 ) 13 - 22 2003.12

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Recenly in the field of clinical dentistry, and particularly in gerodontics, there has been a growing awareness of the importance of nutrition. A lack of chewing ability might be associates with nutritional deficiency, but there is hardly any substantial evidence to support this assumption. This study investigated the effect of chewing ability on intake of total calories, and nutrients by healthy elderly people. The study sample consisted of 512 elderly residents in Niigata City (265 males, 247 females) aged 70 years, who were in good general health and did not require as stance to perform their daily activities. Chewing ability was divided into two categories : being able to chew all foods (15 test foods) was considered "good", and not being able to chew any of the foods was considered "poor". To determine quantitative food intake, a semi-quantitative food frequency questionnaire was utilized during interviews by nutritionists. A personal interview was performed about lifestyle and oral health. QOL (Quality of life) was evaluated using a "Face Scale". Oral examinations, body measurements and blood tests were performed. We evaluated the relationship between chewing ability and subjective symptoms of oral health using odds ratio. Furthermore, relationships between chewing ability and total calorie intake, nutrient and food were investigated using a linear multiple regression model. Poor chewing ability was found in 48% of males and 60% of females. The mean number of teeth present was 17.88 (SD=9.49) for males and 17.01 (SD=9.00) for females. The mean total calorie intake was 1,706.3 kcal (SD=350.8) for males and 1,474.9 kcal (SD=252.3) for females. The variables that significantly affect low chewing ability and the odds ratios were gender (female 1.62), number of teeth present (edentulous participants 8.51, participants with 1-10 teeth 6.03, participants with 11-20 teeth 5.29 compared with participants with 21 or more teeth), the presence of swelling and pain in the gums (2.47), the presence of mobile teeth (1.92), the degree of saliva flow (sufficient 3.13, undetermined 1.70), lower QOL (2.02). In males, total calorie intake and vegetable and fruit intake were significantly lower in the poor chewing category than in the good category according to multiple regression analysis. In females, there was no significant association between the 2 chewing ability categories. Low intake of vegetables and fruits leads to low dietary fiber and vitamin intake. Especially vitamin C, E and carotene are known as antioxidants, and adequate intake of these were thought to prevent cardiovascular disease and gastro-intestinal disease. Lower chewing ability might be a risk factor for these diseases in healthy males aged 70 years or older. In conclusion, the findings suggested that chewing ability might affect total calorie intake and vegetable and fruit intake in healthy males aged 70 years or older.

DOI： 10.5834/jdh.53.1_13

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Root Caries Prevalence and Association between Root Caries and Coronal Caries in the Elderly Reviewed

TAKANO Naoko, YOSHIHARA Akihiro, ANDO Yuichi, OGAWA Hiroshi, HIROTOMI Toshinobu, YAMAGA Takayuki, HANADA Nobuhiro, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 53 ( 5 ) 592 - 598 2003.12

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The purpose of this study was to investigate the prevalence and intraoral distribution of root caries in the elderly, and to identify the association between root caries and coronal caries. Six hundred noninstitutionalized adults aged 70 years in Niigata, Japan were examined for their oral status and general health status. A total of 544 subjects identified as dentate was available for assessment. The prevalence of root caries was evaluated as the percentage of the subjects with one or more root caries and the mean number of teeth with root caries. The intraoral distribution was evaluated as the mean percentage of exposed root surfaces affected by root caries in terms of tooth surface (buccal, lingual, distal, mesial) and tooth group (incisor, canine, premolar, molar). In the analysis of the associations, subjects were divided into 4 groups according to the number of coronal caries first, and then the prevalence of root caries was evaluated in each group. Next, logistic regression analysis where the dependent variable was one or more root caries and the independent variables including the number of teeth with coronal caries was performed. The percentage of male subjects with one or more root caries (DF) was 56.9% and that of female subjects was 53.3%. The mean number of root DFT was 1.81 (SD=2.41) per person for males and that for females was 1.41 (SD=1.93) per person, respectively. As for untreated root caries (D), the percentage of male subjects with one or more root D was 21.7% and that of female subjects was 19.8%. The mean number of root DT for males was 0.46 (SD=1.10) per person and that for females was 0.32 (SD=0.81) per person. The tooth type most commonly affected by root caries in the maxilla was canine and in the mandible it was premolar. The percentage of exposed root surfaces affected by root caries was 17.5% and 11.5%, respectively. As for tooth surface distribution, the buccal surfaces were the most commonly affected with a percentage of 15.8%. The mean number of teeth with root caries and the percentage of subjects with root caries increased with the number of coronal caries. Logistic regression analysis indicated that the prevalence of coronal caries was significantly associated with that of root caries (odds ratio=1.08, p<0.001) after adjusting for other oral variables. In conclusion, the results suggest that the prevalence of root caries in the elderly was high, and the prevalence of coronal caries was associated with root caries prevalence.

DOI： 10.5834/jdh.53.5_592

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Factors associated with root caries incidence in an elderly population

Naoko Takano, Yuichi Ando, Akihiro Yoshihara, Hideo Miyazaki

Community Dental Health 20 ( 4 ) 217 - 222 2003.12

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新潟大学歯学部卒前教育における客観的臨床能力試験(OSCE)の導入 Reviewed

興地隆史, 福島正義, 葭原明弘, 子田晃一, 小野和宏, 小林博, 魚島勝美, 小山純市, 植田耕一郎, 高木律男, 前田健康, 花田晃治

日本歯学教育学会誌 18 ( 2 ) 300 - 307 2003.12

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Epidemiological Study on Marginal and Apical Periodontal Conditions in Japanese Elderly People Using Panoramic Radiograph Reviewed

HIURA Kenji, YOSHIHARA Akihiro, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 53 ( 2 ) 130 - 136 2003.12

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The purpose of this study was to evaluate the radiographically-detected marginal and apical periodontal conditions in elderly people. The subjects were 100 (57 males, 43 females) people at least 70 years old who underwent oral examinations in Niigata City in 1998 (baseline examination), 1999 and 2000. The following parameters calculated on panoramic radiograph were studied for alveolar bone loss and apical periodontal conditions (the existence of periapical lesions, and root canal fillings). We compared subjects by number of teeth and Eichner index (following EI). Third molars were excluded from all analyses. In the baseline study, the rate of nonvital teeth was 36.9%, and the rate of periapical lesions was 35.6%. The mean alveolar bone loss was 30.1% (SD=12.1) in 1998 (baseline examination) and 31.3% (SD=12.2) in 2000. This increase was significant (p<0.05). The mean alveolar bone loss compared by number of teeth was 36.4% in those with 1-9 present teeth, 34.0% for 10-19 present teeth, 27.5% for 20 or more present teeth. The number of teeth lost in 2 years was 50, 7 vital teeth and 43 nonvital. The results of tooth-level multiple logistic regression analysis showed that the incidence of 50% or more alveolar bone loss was high in anterior teeth, molars, males, and 20 or more present teeth. Tooth-level multiple logistic regression analysis showed that the incidence of tooth loss was high in nonvital teeth, teeth with periapical lesions, 50% or more alveolar bone loss, and teeth with clasps. These findings suggest that elderly people with 20 or more present teeth have a low risk of alveolar bone loss and tooth loss. They further suggested that preservation of the pulp was associated with decline of the risk factors for tooth loss.

DOI： 10.5834/jdh.53.2_130

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Improvement in Gingivitis by School Based Prevention Programme at the Elementary School with the Use of Dental Floss after 18 Months Reviewed

Akihiro Yoshihara, Kouichi Fukai, Yuko Morozumi, Toshinobu Hirotomi, Hideo Miyazaki

Journal of Dental Health 53 91 - 97 2003.12

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DOI： 10.5834/jdh.53.2_91

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Factors associated with root caries incidence in an elderly population Reviewed

Naoko Takano, Yuichi Ando, Akihiro Yoshihara, Hideo Miyazaki

Community Dental Health 20 ( 4 ) 217 - 222 2003.12

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Association between serum albumin and root caries in community-dwelling older adults Reviewed

A. Yoshihara, N. Hanada, H. Miyazaki

Journal of Dental Research 82 ( 3 ) 218 - 222 2003

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DOI： 10.1177/154405910308200313

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Longitudinal study on periodontal conditions in healthy elderly people in Japan Reviewed

T Hirotomi, A Yoshihara, M Yano, Y Ando, H Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 30 ( 6 ) 409 - 417 2002.12

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DOI： 10.1034/j.1600-0528.2002.00005.x

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Two-year Cohort Study on Risk Predictors for Tooth Loss in Residing in the Community 70-year-old Subjects Reviewed

SEIDA Yoshikazu, YOSHIHARA Akihiro, ANDO Yuichi, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 52 ( 5 ) 663 - 671 2002.12

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This study investigated the two-year incidence of tooth loss to identify risk predictors for tooth loss in 70-year-old subjects residing in the community. We obtained baseline (1998) and two-year follow-up (2000) data from 402 dentate subjects living in Niigata City. The follow-up rate was 72.6%. To identify risk predictors for tooth loss, variables denoting oral health status and general health status, were obtained using a questionnaire and by performing examinations and blood investigations at the baseline, were included in a multiple logistic regression analysis. Overall, 30.8% of subjects lost one or more teeth with in 2 years after the index year. The mean number of missing teeth per year was 0.27. Tooth loss was frequently observed in this population, however, the distribution of the number of teeth lost was highly skewed. The results of multiple logistic regression analysis showed that tooth loss was greater in persons with BMI (Body mass index)≧24, IgG (Serum immunogloblin)≧1,901 mg/dl, impaired daily physical activities, percentages of sites of LA (Loss of attachment) 6+mm≧4%, nine or more crown restorations and one or more root decayed teeth. The findings from this study suggest that general health status contributes to tooth loss in elderly people, in addition to oral diseases such as root caries and severe periodontal conditions.

DOI： 10.5834/jdh.52.5_663

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Longitudinal study on periodontal conditions in healthy elderly people in Japan

T Hirotomi, A Yoshihara, M Yano, Y Ando, H Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 30 ( 6 ) 409 - 417 2002.12

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Relationship between dental occlusion and physical fitness in an elderly population

T Yamaga, A Yoshihara, Y Ando, Y Yoshitake, Y Kimura, M Shimada, M Nishimuta, H Miyazaki

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 57 ( 9 ) M616 - M620 2002.9

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Risk factors for periodontal disease progression among elderly people Reviewed

Hiroshi Ogawa, Akihiro Yoshihara, Toshinobu Hirotomi, Yuichi Ando, Hideo Miyazaki

Journal of Clinical Periodontology 29 ( 7 ) 592 - 597 2002.7

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DOI： 10.1034/j.1600-051X.2002.290702.x

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Risk factors for periodontal disease progression among elderly people

H Ogawa, A Yoshihara, T Hirotomi, Y Ando, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 29 ( 7 ) 592 - 597 2002.7

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DOI： 10.1034/j.1600-051X.2002.290702.x

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Relationship between dental occlusion and physical fitness in an elderly population Reviewed

Takayuki Yamaga, Akihiro Yoshihara, Yuichi Ando, Yutaka Yoshitake, Yasuo Kimura, Mieko Shimada, Mamoru Nishimuta, Hideo Miyazaki

Journals of Gerontology - Series A Biological Sciences and Medical Sciences 57 ( 9 ) M616 - M620 2002

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DOI： 10.1093/gerona/57.9.M616

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Analysis of vitamin D and Fc gamma receptor polymorphisms in Japanese patients with generalized early-onset periodontitis Reviewed

A Yoshihara, N Sugita, K Yamamoto, T Kobayashi, H Miyazaki, H Yoshie

JOURNAL OF DENTAL RESEARCH 80 ( 12 ) 2051 - 2054 2001.12

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Increased frequency of Fc gamma RIIIb-NA1 allele in periodontitis-resistant subjects in an elderly Japanese population Reviewed

N Sugita, T Kobayashi, Y Ando, A Yoshihara, K Yamamoto, JGJ van de Winkel, H Miyazaki, H Yoshie

JOURNAL OF DENTAL RESEARCH 80 ( 3 ) 914 - 918 2001.3

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Antimicrobial effect of fluoride mouthrinse on mutans streptococci and lactobacilli in saliva Reviewed

Akihiro Yoshihara, Shihoko Sakuma, Seigo Kobayashi, Hideo Miyazaki

Pediatric Dentistry 23 ( 2 ) 113 - 117 2001

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Improvement in Gingivitis by Prevention Program at the Elementary School with the Use of Dental Floss

YOSHIHARA Akihiro, FUKAI Kouichi, MOROZUMI Yuko, HIROTOMI Toshinobu, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 51 ( 5 ) 822 - 827 2001

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According to the Japanese National Oral Health Survey in 1999, the prevalence of gingivitis among 5-14-year-old children is 47.4%. The use of dental floss is important in preventing gingivitis. The present study investigated the effect of a gingivitis prevention program with the use of dental floss. Thirty-nine 5th graders at "M" elementary school (test group) and eighteen 5th graders at "Y" elementary school (control group) were included in this study. Subjects in the test group were instructed by dental hygienists to use dental floss for anterior teeth in combination with regular toothbrushing after lunch. Measurements were carried out by the same dentist at the baseline and at 6 months, using the modified papilla bleeding index and the plaque index for the anterior 10 papillae. At the baseline, there were no differences between the percentages of proximal bleeding sites per person, of plaque per person, or the percentage of subjects using dental floss in their own home. During a 6-month period, the number of bleeding sites per person decreased from 4.67 (SD=3.01) to 3.03 (SD=2.70) in the test group, and increased from 4.59 (SD=2.50) to 5.41 (SD=3.43) in the control group. There was a significant difference in the reduction of bleeding sites in both groups (p=0.003, Mann-Whitney U test). The number of plaque sites per person decreased from 4.64 (SD=3.02) to 3.41 (SD=2.68) in the test group, and increased from 5.12 (SD=2.93) to 6.41 (SD=2.62) in the control group. There was a significant difference in the reduction of plaque sites in both groups (p=0.003, Mann-Whitney U test). The percentages of subjects using dental floss in their home after instruction during the baseline period was 51.5% for the test group and 22.2% for the control groups (p=0.023, chi-square test). These results show that a gingivitis prevention program including the use of dental floss contributes to the prevention of gingivitis in school children. It is suggested that the program in the present study is relatively easy to include in a school-based dental program and can be widely used.

DOI： 10.5834/jdh.51.5_822

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Three-Year Incidence of and Risk Predictors for Tooth Loss in Community-dwelling Adults

ANDO Yuichi, YOSHIHARA Akihiro, SEIDA Yoshikazu, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 51 ( 3 ) 263 - 274 2001

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The purpose of this study was to evaluate the three-year incidence of and risk predictors for tooth loss in community-dwelling adults. The subjects were 269 (128 males, 141 females) dentate adults living in a town in Niigata Prefecture who underwent oral examinations in both 1997 (baseline examination) and 2000 (follow-up examination). The follow-up rate was 37.2%. The mean age at baseline was 60.6 (SD = 12.8). A multiple-logistic regression model was used to quantify tooth-specific and person-level risk predictors for tooth loss using variables of the oral examination and questionnaire at baseline. The three-year incidence of tooth loss was 4.9% at tooth-level, 48% at person-level. The mean number of missing teeth per year was 0.33. The results of person-level multiple logistic regression analysis showed that tooth loss was more common in people with 10-27 present teeth, decayed teeth, oral symptoms, history of dental visit within a year and no habit of using an interdental brush or dental floss. Tooth-level multiple logistic regression analysis showed that the incidence of tooth loss was higher in wisdom teeth, decayed teeth, crowned teeth, abutment teeth in bridges and teeth with mobility.

DOI： 10.5834/jdh.51.3_263

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高齢者における歯周組織破壊のRisk Indicatorについて

小川祐司, 広富敏伸, 葭原明弘, 安藤雄一, 宮崎秀夫

新潟歯学会雑誌 30 ( 2 ) 264 - 264 2000.12

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Factors Related to Dental Caries Prevalence in Children with Low Caries Level

YOSHIHARA Akihiro, SAKUMA Shihoko, WANG Jing, MATSUMURA Seishi, SHIMONO Tsutomu, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 50 ( 1 ) 83 - 88 2000

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This cross-sectional study investigated factors related to dental caries prevalence in a low caries group. The subjects consisted of 89 schoolchildren aged 12 years. The children had participated in a fluoride mouth rinse program since 5 years of age at nursery schools. Furthermore, pit and fissure sealants were applied to teeth with sticky fissures when detected at dental check-ups twice a year. Clinical examinations were conducted to obtain data on caries prevalence (dfs and DMFS). The salivary level of mutans streptococci, the salivary level of lactobacilli, and the acid production by bacteria in the plaque were measured using Dentocult SM Strip ® , Dentocult LB Dip Slide ® , and Cariostat ® , respectively. In addition, we obtained information on gender, sum of permanent tooth surfaces sealed, toothbrushing frequency, sweet snack frequency, sweet drink frequency, use of fluoridated toothpaste, and stimulated salivary flow rate. Stepwise backward logistic multiple regression analysis was used to estimate the relationship between caries prevalence and 11 total independent variables. Furthermore, we obtained information about some reasonable linear discriminators that could identify subjects with high caries experience using the final logistic multiple regression model. Thereafter, we calculated sensitivity, specificity, and Youden's index according to the classification table. As the results of stepwise backward logistic multiple regression analysis, three variables (number of sealants, the level of Cariostat R , and frequency of sweet snacks) were selected as independent variables in the final model. The level of CariostatR showed the highest odds ratio (Odds ratio : 6.87, p=0.02). The cutpoints at which Youden's index showed the highest value, sensitivity, and specificity were 76.9% and 75.7%, respectively. According to these findings, it is safe to say that we could propose that the plaque level of Cariostat ® might be the most important variable related to caries prevalence.

DOI： 10.5834/jdh.50.1_83

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A Comparative Study of Glass Ionomer and Resin-based Material Used as Fissure Sealants on the First Molars -with Incipient Remineralization

YOSHIHARA Akihiro, SAKUMA Shihoko, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 50 ( 5 ) 777 - 782 2000

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Pit and fissure sealants have been accepted as a caries preventive strategy and have a great effect on preventing dental caries on the pit and fissure surfaces of permanent molar teeth. The retention for resin-based sealant is better than for glass ionomer sealant, but the difference in caries prevention remains equivocal. The aim of this study was to compare the caries preventive effect and retention of a glass ionomer cement (GIC) and a resin-based sealant (RBS). GIC (n=61) or RBS (n=82) was applied on the occlusal surfaces of permanent first molars with Sticky Fissure in school children (n=108), mean age=9.50±1.57 (S. D.). All sealants were applied by two operators using standard procedures and were assessed at baseline and every 6 months thereafter. Assessment criteria were based upon the inefficient status rate (Sticky Fissure or dental caries) and on the occurrence of caries. After 2 years, the ineffective status rate was 23.2% on the RBS compared to 36.1% on the GIC (p<0.05, Wilcoxon's test). For the evaluation of material for sealing, logistic multiple regression analysis was performed. As dependent variables, inefficient status (yes=1, no^O) was used. As independent variables, age, sealant material (RBS=1, GIC=2), DMFT at baseline and jaw (upper=1, lower=2) were used. The inefficient status was associated with the sealant material (Odds ratio: 1.61, p=0.04), after adjusting for age, DMFT at baseline and jaw. In addition, there were a total of eight occurrence of caries, three (4.9%) in teeth sealed with GIC and five (6.1%) in teeth sealed with RBS. The difference in the percentage of the occurrence of caries between teeth sealed with RBS or GIC was not significant. In conclusion, there was no significant difference in caries prevention using GIC compared to RBS. However, there was significantly better retention with RBS.

DOI： 10.5834/jdh.50.5_777

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Survival of Fissure Sealants and Preventive Resin Restorations Applied over Early Occlusal Carious Lesions

SAKUMA Shihoko, YOSHIHARA Akihiro, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 50 ( 5 ) 765 - 771 2000

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The purpose of this study was to evaluate the clinical success of fissure sealants (SR) and preventive resin restorations (PRR) which were applied over occlusal carious lesions and to discuss the availability of these methods in a program which manages recently erupted permanent molars by means of prevention and treatment of occlusal dental caries. A preventive resin restoration is a conservative treatment that involves limited excavation to remove carious tissue, restoration of the excavated area with a composite resin, and application of a sealant over the surface of the restoration and the remaining sound, contiguous pits and fissures. Subjects were 57 children aged between 8 and 14 years, at the last examination and who had teeth treated with either SR or PRR. They had been participating in a school-based fluoride mouthrinse program from the age of 5 years, which was combined with a targeted sealant-sealant was selectively applied on the fissure detected as sticky using an explorer-in elementary school. Sixty six teeth-64 first and 2 second permanent molars-were evaluated. Carious lesions that did not exceed a width of 2 mm in a pit or fissure of these teeth were detected. Accordingly, SR or PRR were applied on them. An excavation performed with a small round bur (# 1/2) was indicated for SR, while excavation using a bigger bur was indicated for PRR. After these lesions were treated with either SR or PRR, they were assessed twice a year. The mean period of observation was 3.4 years, with a range of 1 to 7.5 years. Out of 45 teeth to which we applied SR, 9 teeth developed secondary caries. In the case of PRR 3 teeth out of 21 teeth developed secondary caries. The cumulative survival rate for subject teeth after 7.5 years was 71.9±8.0 (SE)% as detected by Kaplan-Meier survival functions; thus, the cumulative incidence of secondary caries was 28.1%. There was no significant difference between the cumulative survival rate for SR (71.0 ± 9.1%; after 7.5 years) and that for PRR (75.2 ± 14.8%; after 5.5 years) as determined by generalized Wilcoxon analysis. And stepwise multivariate logistic regression analysis indicated that the school grade at which carious lesion was detected first had a significant impact on the development of secondary caries after SR or PRR application. A cavity detected at the 1st and 2nd grade was at a larger risk (odds ratio=4.56) than that was detected at higher grades. Similar findings have been reported earlier. It is, therefore, recommended that these treatment methods, which are indicated for small and discrete pit or fissure caries, be adopted in dental clinics practicing preventive measures of dental caries, including fluoride use. It is also suggested that the condition of sealant or resin restoration be observed periodically, in order to maintain it properly.

DOI： 10.5834/jdh.50.5_765

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An Evaluation and Comparison of Visual Inspection, Electrical Caries Monitor and Caries Detector Dye Methods in Detecting Early Occlusal Caries in Vitro Study

WANG Jing, SAKUMA Shihoko, YOSHIHARA Akihiro, KOBAYASHI Seigo, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 50 ( 2 ) 223 - 230 2000

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The purpose of this study was to evaluate and compare three diagnostic methods in detecting early caries in occlusal surfaces. Three different methods, namely, visual inspection (VI), electrical caries monitor (ECM) and a caries detector dye (Dye) were used to diagnose occlusal caries in extracted teeth. One hundred sixty-one sites in a total of 42 extracted teeth were examined by three examiners with VI and ECM methods, whereas the Dye method to detect caries was tested by only one examiner. Histological examination of the teeth served as a validating criterion to evaluate the ability of each method to diagnose caries. Of 161 sites, 82, 96 and 96 sites were diagnosed as having caries by the VI, ECM and Dye methods, respectively, compared with 85 sites by histological validation. ECM showed the highest level in sensitivity (85%), followed by VI (67%) and Dye (63%). In the ROC analysis, the areas under ROC reached 0.73, 0.89 and 0.61 for the VI, ECM and Dye methods, respectively. The kappa values ranged from 0.64-0.80 and 0.75-0.82 in intra- and inter-examiners for ECM, respectively, and between 0.53-0.82 and 0.29-0.70 for VI. It was concluded that the ECM method is more valid and reproducible than VI or Dye for the diagnosis of occlusal caries.

DOI： 10.5834/jdh.50.2_223

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個別保健指導及びパンフレット郵送の成人歯科保健に対する有効性成人女性を対象として

葭原明弘, 八木稔, 澤村恵美子, 金子昇, 宮崎秀夫

口腔衛生学会雑誌 49 ( 5 ) 809 - 815 1999.10

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2歳時健康診査受診者の内,3歳児健康診査も受診した244人の母親を対象とした.テスト群(177人)には,歯科衛生士が対象者1人あたり約10分の個別指導を実施した.母親の口腔健康状態には1年間で変化は認められなかった.歯間ブラシ又はフロスを補助清掃用具として使用している割合は,コントロール群では15.0%(ベースライン)から17.3%(1年後)と同様の使用率であったのに対し,テスト群では17.1%(ベースライン)から28.2%(1年後)と有意に増加した.又,1年後の補助用具の使用の有無に対し,有意な要因として選択されたものは,ベースライン時の補助用具の使用,歯科医より歯周疾患の情報入手及び歯科衛生士による個別指導の3変数であった

DOI： 10.5834/jdh.49.5_809

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The Incidence Risk for Dental Caries from Brown-Stained Pit and Fissure in the First Molars of Schoolchildren

YOSHIHARA Akihiro, SAKUMA Shihoko, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 49 ( 3 ) 324 - 328 1999

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The purpose of this study was to obtain information on the caries risk of brown-stained pits and fissures in the first molars. Six hundred thirty-three elementary schoolchildren were selected as sample subjects. The children had participated in a fluoride mouthrinse program since 5 years of age at nursery schools, in addition to having received routine dental education. The screening method consisted of two steps. First, we selected questionable caries for observation (CO teeth) at the school examination. Next, at the second step, we classified the CO teeth into those having brown-stained pits and fissures or sticky fissures, determined at a dental clinic examination. The progression of caries from the brown-stained (86 teeth) and sound (168 teeth) pits and fissures during the next 6 months was compared using the ratio of relative risk. In addition, we evaluated the factors related to the caries progression for 6 months by logistic regression analysis. As a dependent variable, caries occurrence (0: DMFT=0, II DMFT ≥ 1) was used. As independent variables, school grade (1-6), the number of DMFT (0-4), the number of teeth with brown-stained pits and fissures (0-4) and the number of teeth with sticky fissures (0-4) at baseline were used. The percentage of teeth progressing to caries during this 6 month period was 1.2% (2 out of 168) of sound teeth, and 7.0% (6 out of 86) of teeth with brown-stained pits and fissures. The difference in the progression ratio between the two groups was statistically significant (p = 0.02, Fisher's exact test) and the ratio of estimated relative risk was 5.86 in the teeth with brown-stained pits and fissures against the sound teeth. Furthermore, according to logistic regression analysis, only DMFT showed a significant odds ratio (Odds ratio: 2.38, p=0.02). The results of the study demonstrated that the influence of caries activity on teeth with brown-stained pits and fissures might be low. Furthermore, the risk of progression of teeth with brown-stained pits and fissures to dental caries might be lower than the risk of teeth with sticky fissures, according not only to the results of this study, but also to the results of our previous report on the same school as in this study. We should concentrate on caries prevention especially for teeth with sticky fissures because of their high susceptibility to caries. For making a more efficient caries prevention program, we should make a new connection system between screening examinations at school and treatment for prevention with detailed examination at a dental clinic.

DOI： 10.5834/jdh.49.3_324

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Economic Aspects of Pit and Fissure Sealants as Caries Preventive Measures Reviewed

YOSHIHARA Akihiro, SAKUMA Shihoko

JOURNAL OF DENTAL HEALTH 47 ( 5 ) 703 - 716 1998.1

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A number of clinical studies on treatment of pit and fissure sealants have been made and have concluded that sealants are an effective measure for dental caries prevention. However, it has not yet been established whether sealant application is cost-effective or not. The purpose of this study was to evaluate the cost-effectiveness of sealant application by different standard and to define a major factor which influences the most effective standard. 854 sound 1 st permanent molars in 290 primary schoolchildren between the 1 st and 3 rd grades were selected for this study. When 4 different kinds of adaptation standards were adopted for sealant for the 1 st permanent molars, each cost-effectiveness was compared by simulation in the subjects. The criteria chosen as standards were 1) only teeth with slight sticky fissure (SF), 2) healthy teeth contralateral to one which was carious or filled, 3) all 4 teeth only in subjects whose all 4 second primary molars were decayed or filled, and 4) all 4 teeth in all the subjects. The expected utility value (the costs for sealant and, if needed, for restorative treatment per tooth over time) and cost-effectiveness ratio were calculated for the 4 different adaptation standards, respectively. When adopting each standard, the clinical decision analysis showed that standard # 2 (the opposite tooth was carious) was the lowest at 199 yen, standard # 1 (SF) was the next (289 yen), followed by standard # 3 (all the second primary molars were carious ', 526 yen) and standard # 4 (all teeth ; 1,520 yen). In same way, the cost-effectiveness ratio showed that standard # 1 (SF) was 6,004 yen, # 2 was 10,193 yen, # 3 was 17,668, and # 4 was 27,282, respectively. The cost-effectiveness for sealant was estimated to be changeable with different level of caries prevalence by population group. If there are relatively few people with carious molars, the sealant should be applied only to the sticky fissures. On the other hand, the sealant should be applied to all pits and fissures in groups having high caries prevalence, such as the case simulated in this study where more than 80% of first molars were affected by dental caries for 3 years. In conclusion, these results clearly indicate that the sealant program adopting only sticky fissures as an adaptation standard is the most cost-effective, and that the sealant program, including a decision for adaptation standard, should be planned by caries prevalence level in population groups or sub-groups.

DOI： 10.5834/jdh.47.5_703

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Evaluation of a Preventive Program for Dental Caries in Primary Dentition from Early Stage of Life

SAWAMURA Emiko, YOSHIHARA Akihiro, YAGI Minoru, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 47 ( 3 ) 292 - 297 1997

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A preventive program for dental caries in primary dentition from 10 months to 1 year and 6 months of age was evaluated. The program began in 1990. Subjects were 230 children who lived in a town of Niigata Prefecture, Japan. Topical fluoride application with acidulated 2% sodium fluoride was a major tool of the program. The program also included dental health education with tooth brushing and milk feeding instructions. Principally, the subjects were recalled at intervals of about 3 months. However, some children regarded as having a high risk of dental caries were recalled according to an original screening criteria. In the town, prevalence of dental caries in primary teeth had remained moderate to high before introduction of the program. Dental examination at 1 year and 6 months of age was carried out from 1991 to 1993. The percentage of children with dental caries decreased from 22.9% in 1991 to 8.0% in 1993 (reduction of 14.9 points, p<0.01). The mean number of decayed, missing, and filled teeth declined from 0.77 to 0.28 in 1991 and 1993, respectively (63.6% reduction, p<0.05). It is concluded that the program motivated the guardians of the children to receive topical fluoride application and to improve oral hygiene habits of the children. The program is considered to be good and feasible for any community with moderate to high level of dental caries in primary teeth.

DOI： 10.5834/jdh.47.3_292

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The Reliability of Self-assessment of Number of Remaining Teeth Using Questionnaires

ANDO Yuichi, IKEDA Satoshi, YOSHIHARA Akihiro

JOURNAL OF DENTAL HEALTH 47 ( 5 ) 657 - 662 1997

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The purpose of this study was to compare numbers of remaining teeth from questionnaires and clinical examination and to determine whether information collected through questionnaires is sufficiently reliable for use at community level. The subjects studied were 2,496 adults living in 3 municipalities in Niigata Prefecture. The number of remaining teeth was determined not only from replies to questionnaires by subjects but from clinical examination by 19 dentists. The average score of remaining teeth was 19.59 by questionnaire and 19.60 by oral examination. The difference between the 2 average scores was very small and insignificant by t-test. In each age group, this difference was also small and insignificant. Correlations between questionnaires and clinical examination were extremely high (r = 0.93). In conclusion, questionnaires can give sufficiently reliable data about remaining teeth even if data from clinical examination are not obtained.

DOI： 10.5834/jdh.47.5_657

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Caries Prevalence and Missing Teeth among the Workers at the Prefectural Office of Niigata

YOSHIHARA Akihiro, KOBAYASHI Seigo, TAKATOKU Yukio, KAZIYAMA Toru, ANDO Yuichi, HORII Kin-ichi

JOURNAL OF DENTAL HEALTH 45 ( 5 ) 826 - 828 1995

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DOI： 10.5834/jdh.45.5_826

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Treatment and Posttreatment Effects of Fluoride Mouthrinsing after 17 Years

Seigo Kobayashi, Hiroshi Kishi, Akihiro Yoshihara, Kin‐ichi Horii, Akihito Tsutsui, Tatsuo Himeno, Alice M. Horowitz

Journal of Public Health Dentistry 55 ( 4 ) 229 - 233 1995

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DOI： 10.1111/j.1752-7325.1995.tb02374.x

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The Prevalence of Dental Fluorosis and Non-fluoride Enamel Mottling in the Natural Fluoride Areas, Japan.

TSUTSUI Akihito, TAKIGUCHI Toru, SAITO Shin-ichi, TAMURA Takuya, YAGI Minoru, ANDO Yuuichi, KISHI Hiroshi, KOBAYASHI Hideto, YANO Masatoshi, YOSHIHARA Akihiro, WATANABE Yuzo, KOBAYASHI Seigo, SAKUMA Shihoko, NOGAMI Shigeki, KOIZUMI Nobuo, NAKAMURA Munetou, WATANABE Takeshi, HORII Kin-ichi, SAKAI Osamu

JOURNAL OF DENTAL HEALTH 44 ( 3 ) 329 - 341 1994

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The optimal fluoride concentration has not been determined because there were few epidemiological studies about dental fluorosis in Japan. The purpose of this study was to investigate the relationship between the prevalence of enamel mottling and fluoride concentration in drinking water in Japan. We began to look for naturally fluoridated areas in central Japan in 1978. As a result, we found 7 communities in 5 prefectures. There were 26 water supply systems in their communities, and their fluoride concentrations ranged from 0 to 1.4ppm. Subjects for analysis were 1, 081 children aged 10-11 who had lived in the communities from birth. Dean's Index was used for the classification of dental fluorosis, and non-fluoride enamel mottling was classified in the same way as Dean's Index, too. A significant positive correlation (r=0.485, p<0.05) was found between the prevalence of dental fluorosis (very mild or mild types) and fluoride concentration and a negative correlation (r=-0.429, p<0.05) was found between the prevalence of non-fluoride enamel mottling and fluoride concentration. There was no relationship (r=-0.129, ns) between the prevalence of all enamel mottling and fluoride concentration. We could not find moderate or severe types of dental fluorosis in these investigations and CFI ranged from 0.04 to 0.30. We concluded that there was no problem concerning dental fluorosis from 0 to 1.4ppm fluoride concentration in the drinking water in these communities. We believe that these findings make up for the insufficiency of the epidemiological study of dental fluorosis in Japan.

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A Reasonable Sealant Program for First Molars of Schoolchildren in a FMR Program.

YOSHIHARA Akihiro, KOBAYASHI Seigo, SAKUMA Sihoko, ANDO Yuichi, MINETA Kazuhiko, HORII Kin-ichi, TAKIGUCHI Toru

JOURNAL OF DENTAL HEALTH 44 ( 3 ) 260 - 266 1994

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In order to establish a more efficient program combining pit and fissure sealant with school-based fluoride mouthrinsing, we designed a program based on a screening method in which pits and fissures with higher caries sensitivity were selected using 4 indices and sealed. These 4 indices were sticky fissures diagnosed as CO, occlusal index, occlusal plaque index (O.P.I), and school grade. The purposes of this study are the evaluation of the usefulness of the program. The subjects, 1st to 3rd graders, were 465 children in elementary school Y and 175 children in elementary school W. The children lived in two neighboring villages which are similar in socioeconomic environment. They had participated in a school-based fluoride mouthrinsing program (FMR) since nursery school. The FMR consisted of rinsing daily with 0.05% NaF from 4 years of age at in nursery school and rinsing weekly with 0.2% NaF after entrance to elementary school. The screening method consisted of two steps. In the first step, sticky fissures in the occlusal surfaces, buccal pits, and lingual grooves of all 4 first permanent molars were diagnosed as CO. In the second step, the CO surfaces were evaluated based on occlusal index, O.P.I., and school grade. The surfaces evaluated as being in poor condition by these indices were distinguished as high risk CO (H-CO) from the other CO surfaces estimated as low risk CO (L-CO). In school Y light-polymerized opaque sealants were applied to H-CO surfaces and L-CO surfaces were left without any application until the next examination 6 months later. In school W both H-CO and L-CO surfaces were left without any application. The progression of caries from the previous level, i.e., sound, sealant applied, H-CO, or L-CO, was compared every 6 months. In school Y the percentage of surfaces progressing to above C1 after 6 months was 0.3% in sound, 12.5% in L-CO, and 0% in sealant-applied surfaces. The percentage of complete retention of sealant was 93.1%. The ratio of relative risk estimated was 50.0 in L-CO surfaces against sound surfaces. In school W the percentages of progressing surfaces were 1.6% in sound, 32.9% in H-CO, 17.6% in L-CO, and 30.1% in the total CO surfaces. The ratio of relative risk estimated was 18.8 in the total CO surfaces against sound surfaces and 1.9 in H-CO against L-CO. It was confirmed that CO surfaces, especialy H-CO surfaces selected by this screening method had more risk of dental caries. The relative risk of sound surfaces in progressing to dental caries was very low. Accordingly it was reasonable that the sealings were applied only to occlusal surfaces selected by the screening method without sealing all the occlusal surfaces. It was concluded that this program of selecting CO surfaces and applying sealant particularly to H-CO surfaces was appropriate for decreasing the cost of sealant application.

DOI： 10.5834/jdh.44.260

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An Epidemiological Study of Caries Prevalence, Daily Habits and Environment of Kindergarteners and Schoolchildren in Taiwan R.O.C.

WU Chicheng, TSUTSUI Akihito, WATANABE Takeshi, GUNJISHIMA Yuka, SOEJIMA Takashi, YAMASAKI Akihiro, FUJII Tojiro, TANAHARA Hidehito, MATSUNAGA Shouzo, TING Shengtsung, YEN Tungchieh, SAKAI Osamu, KOBAYASHI Seigo, SAKUMA Shihoko, ANDO Yuuichi, YOSHIHARA Akihiro, HORII Kin-ichi

JOURNAL OF DENTAL HEALTH 42 ( 3 ) 264 - 276 1992

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An epidemiological study of 2, 012 children by oral examination and questionnaire was undertaken to study the dental caries prevalence in one kindergarten and two elementary schools in an urban area and in one kindergarten and two elementary schools in a country area in 1989. The data showed that the dental health status was poor and that living habits and public medical service were unsatisfactory when compared with the results of other dental surveys in Taiwan R.O.C.. In the urban area caries prevalence in deciduous teeth in the kindergarten was 74.2%, and in permanent teeth in the two elementary schools it was 56.3% and 57.1%. In the country area caries prevalence in deciduous teeth in the kindergarten was 95.0% and in permanent teeth in the two elementary schools it was 68.0% and 56.4%, respectively. The dft index was 6.30 in the urban area and 9.00 in the country area, and the DMFT index was 1.87 and 1.58 in the urban area, and 2.02, 1.52 in the country area. The FT rate showed a low restorative treatment rate in both deciduous and permanent teeth. The ft rate was from 1.4% to 6.3% in kindergarteners and FT rate in elementary school children was from 10.5% to 35.6%. The results of the questionnaire regarding living habits, living environment and medical service were as follows: 1. Subjects who received topicl fluoride application or regular dental examination were few and there was a high percentage of experience of toothache and dental treatment. But because of the deficient public health system, the treatment of dental caries was mostly temporary treatment only, and therefore experience of both toothache and dental treatment were frequent. 2. The answers to the questionnaire showed that the parents know and acknowledge the use of fluoride. Our dental survey showed that dental caries is increasing in Taiwan and is near the level of Japan. There is no obvious difference in the public dental health situation or the living environment between the regions surveyed, and no definite direction could be observed between caries prevalence and living habits or living environment. The knowledge and acknowledgement of parents concerning fluoride will help to establish a community dental policy and contribute to the developement of school dental health.

DOI： 10.5834/jdh.42.264

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抗酸化ビタミンと歯周病、食と医療特集2 抗酸化ビタミンと疾患との関係 6

岩﨑正則, 佐藤美寿々, 葭原明弘, 宮﨑秀夫（ Role： Joint author）

indd 2018

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第10章 Ⅴ成人保健、Ⅵ高齢者保健、Ⅶ産業歯科保健、Ⅷ精神歯科保健、デンタルスタッフの口腔衛生学

葭原明弘（ Role： Joint author）

医歯薬出版 2018

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歯科疾患（う蝕、歯周病、咀嚼機能低下）と生活習慣病, 臨床歯科栄養学

葭原明弘, 岩崎正則（ Role： Joint author）

口腔保健協会 2018

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高齢者における口腔と栄養

岩崎正則, 小川祐司, 木村友美, 葭原明弘（ Role： Joint author）

ヘルスサイエンス・ヘルスケア 2018

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日本一子どものむし歯が少ない県の秘密とは？

葭原明弘（ Role： Sole author）

nico 2017

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デンタルスタッフの衛生学・公衆衛生学、学校保健

葭原明弘（ Role： Sole author）

医歯薬出版 2016

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Nutrition- Dental/oral health and nutrition, The current evidence of dental care and oral health for achieving healthy longevity in an aging society 2015

Hideo Miyazaki, Masanori Iwasaki, Akihiro Yoshihara, Yuichi Ando（ Role： Joint author）

Japan Dental Association, Loyal Planning Co., Ltd. 2015

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栄養と口腔保健 -NCDsリスクとの観点から-

岩崎正則, 葭原明弘, 安藤雄一, 安細敏弘, 宮崎秀夫（ Role： Joint author）

ヘルスサイエンス・ヘルスケア 2015

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歯周病と腎機能、Annual Review 腎臓 2014

岩崎正則, 葭原明弘, 宮﨑秀夫（ Role： Joint author）

中外医学社 2014

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歯科保健活動で「地域とつながる」ということ

葭原明弘（ Role： Joint author）

医学書院 2013

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Chronic Kidney Disease, Realtionship among renal function, bone turnover and periodontal disease

Yoshihara A, Hanindriyo L（ Role： Sole author）

Inteck 2012

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学校歯科ハンドブック

葭原明弘（ Role： Joint author）

新潟県歯科医師会、新潟県教育委員会、新潟市 2011

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歯の数・口腔機能と健康，健康寿命を延ばす歯科保健医療，歯科医学的根拠とかかりつけ歯科医

葭原明弘, 宮﨑秀夫（ Role： Joint author）

医歯薬出版 2009

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歯周病予防のストラテジー

吉江弘正, 宮田隆編, 葭原明弘他（ Role： Sole author）

医歯薬出版 2009

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健康寿命を延ばす歯科保健医療、歯科医学的根拠とかかりつけ歯科医、「歯の数・口腔機能と健康」

葭原明弘, 宮﨑秀夫（ Role： Joint author）

医歯薬出版 2009

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う蝕学－チェアサイドの予防と回復のプログラム

葭原明弘, 宮﨑秀夫（ Role： Joint author）

永末書店 2008

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歯医者さんが、まちづくりＮＰＯに出会った！

葭原明弘（ Role： Joint author）

新潟日報事業社 2008

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Preventive Periodontology

葭原明弘, 宮崎秀夫（ Role： Joint author , 147-151）

医歯薬出版 2007.12

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みんなでワッ歯ッ歯

葭原明弘（ Role： Joint author）

新潟日報事業社 2007

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高齢者の術後回復に及ぼす口腔ケアの有効性に関する無作為化臨床研究

葭原明弘（ Role： Sole author）

[葭原明弘] 2005

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臨床検査

葭原明弘, 宮崎秀夫（ Role： Joint author , 567-570）

医学書院 2004.12

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実践予防歯科ハンドブック

葭原明弘（ Role： Joint author , 162-163）

予防歯科臨床協議会編 2004.12 （ ISBN:4263455762 ）

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新しい健康科学への架け橋,歯周病と全身の健康を考える

葭原明弘, 宮崎秀夫（ Role： Joint author , 132-136）

財団法人ライオン歯科衛生研究所 2004.12 （ ISBN:4263441850 ）

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新予防歯科学第3版

葭原明弘（ Role： Joint author , 13章）

医歯薬出版株式会社 2003.12 （ ISBN:4263455673 ）

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歯科でいかそう健康増進法

葭原明弘（ Role： Joint author , 158-159）

8020財団 2003.12 （ ISBN:4263441664 ）

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保健医療におけるコミュニケーション・行動学

葭原明弘, 宮崎秀夫（ Role： Joint author , 13章）

医歯薬出版株式会社 2002.12 （ ISBN:426345524X ）

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食事摂取におけるNa/K比と現在歯数との関連(魚沼コホート研究)第二報:調味料・食品との関連

諏訪間加奈, 岩崎正則, 伊藤由美, 中村夢衣, 柴田佐都子, 竹原祥子, 葭原明弘

口腔衛生学会雑誌 75 2025

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食事摂取におけるナトリウム/カリウム(Na/K)比と現在歯数との関連(魚沼コホート研究)第一報

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腎機能と自己申告による現在歯数との関連(魚沼コホート調査ベースラインデータより)—Relationship between Renal Function and Self-reported Number of Current Teeth (From the Uonuma Cohort Study Baseline Data)

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口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health / 日本口腔衛生学会編 74 ( 2 ) 125 - 134 2024.4

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標準的な成人歯科健診プログラムに準じた個別指導による歯科保健行動変容への影響—Effects on Oral Health Behavioral Change of Personal Instruction Based on New Dental Health Program for Adults

諏訪間加奈, 藤井香那, 髙橋純子, 葭原明弘

口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health / 日本口腔衛生学会編 74 ( 2 ) 99 - 107 2024.4

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高野綾子, 柴田佐都子, 沖津佳子, 濃野要, 葭原明弘

口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health / 日本口腔衛生学会編 74 ( 2 ) 92 - 98 2024.4

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桜井花菜, 桜井花菜, 柴田佐都子, 米澤大輔, 葭原明弘, 濃野要

日本歯科衛生学会雑誌 19 ( 1 ) 2024

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抗Porphyromonas gingivalis IgG血清抗体価と肝機能マーカー値および肥満との関連性-佐渡コホートにおける横断研究-

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新潟歯学会雑誌 50 ( 2 ) 2020

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日本歯科衛生学会雑誌 14 ( 1 ) 106 - 106 2019.8

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血清抗Porphyromonas gingivalis IgG抗体価と肝機能マーカー値の関連性-新潟県佐渡市における横断研究-

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日本歯周病学会会誌(Web) 61 2019

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地域在住高齢者における唾液量と血中コレステロールの関連

溝口奈菜, 濃野要, 金子昇, 小川祐司, 葭原明弘

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新潟歯学会雑誌 49 ( 2 ) 2019

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地域在住高齢者における唾液量と血中コレステロールの関連

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セルフレポートによる歯周病有病者の検出についての検討

皆川久美子, 葭原明弘, 佐藤美寿々, 深井穫博, 安藤雄一, 嶋崎義浩, 古田美智子, 相田潤, 神原正樹, 宮崎秀夫

口腔衛生学会雑誌 68 ( 増刊 ) 143 - 143 2018.4

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皆川久美子, 葭原明弘, 佐藤美寿々, 深井穫博, 安藤雄一, 嶋崎義浩, 古田美智子, 相田潤, 神原正樹, 宮崎秀夫

口腔衛生学会雑誌 68 ( 1 ) 37 - 38 2018.1

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地域在住高齢者における臼歯部の咬合支持の変化と低栄養(PEM)の関連に関する縦断的研究

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新潟歯学会雑誌 48 ( 2 ) 2018

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日本人成人において血中肝機能マーカー高値と歯槽骨吸収度との間に関連性は見られるか? 横断研究

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新潟歯学会雑誌 47 ( 2 ) 116 - 116 2017.12

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高齢者における口腔と栄養

岩崎正則, 小川祐司, 木村友美, 葭原明弘, 宮崎秀夫

ヘルスサイエンス・ヘルスケア 17 ( 2 ) 46 - 52 2017.12

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政策声明認知症に対する口腔保健の予防的役割

葭原明弘, 安藤雄一, 深井穫博, 安細敏弘, 伊藤博夫, 佐々木健, 山本龍生, 皆川久美子, 宮本茜, 岩崎正則, 竹内研時, 日本口腔衛生学会, 日本口腔衛生学会疫学研究委員会および政策声明委員会

口腔衛生学会雑誌 67 ( 4 ) 251 - 259 2017.10

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委員会報告日本人における歯周病のセルフレポートに関する文献レビュー

葭原明弘, 安細敏弘, 伊藤博夫, 佐々木健, 山本龍生

口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health 67 ( 3 ) 196 - 200 2017.7

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特別養護老人ホーム入所者における自発摂食評価と死亡率との関係 30ヵ月間のコホート研究

坂本まゆみ, 渡邊裕, 葭原明弘

新潟歯学会雑誌 47 ( 1 ) 52 - 53 2017.6

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高齢者のオーラルセルフケアに関する学会提言 2017年2月28日

宮崎秀夫, 森田学, 深井穫博, 安藤雄一, 眞木吉信, 村上伸也, 桃井保子, 平野浩彦, 相田潤, 葭原明弘, 山賀孝之, 町田達哉, 多田紗弥夏, 内藤徹, 伊藤加代子, 花田信弘, 野村義明, 一般社団法人日本口腔衛生学会, 高齢者のオーラルセルフケア検討委員

口腔衛生学会雑誌 67 ( 2 ) 94 - 117 2017.4

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高齢者のオーラルセルフケアフッ化物以外のセルフケアによるう蝕予防 (高齢者のオーラルセルフケアに関する学会提言)

葭原明弘, 山賀孝之

口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health 67 ( 2 ) 100 - 102 2017.4

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一時保護児童のう蝕状況に関する実態調査

野上有紀子, 岩瀬陽子, 葭原明弘, 大内章嗣, 高橋英樹, 中川兼人, 早崎治明

新潟歯学会雑誌 46 ( 2 ) 116‐117 - 117 2016.12

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齲蝕予防のためのフッ化物洗口プログラム経験に対する青年期における評価

米澤大輔, 八木稔, 葭原明弘, 福島正義

日本歯科衛生学会雑誌 11 ( 1 ) 77 - 77 2016.8

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Streptococcus sobrinus臨床分離株のgtfI遺伝子における多様性の検討

金子昇, 濃野要, 山賀孝之, 葭原明弘, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 66 ( 2 ) 284 - 284 2016.4

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Effects of Periodontal Diseases on Diabetes-Related Medical Expenditure

Masanori Iwasaki, Misuzu Sato, Akihiro Yoshihara, Hideo Miyazaki

Current Oral Health Reports 3 ( 1 ) 7 - 13 2016.3

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DOI： 10.1007/s40496-016-0076-0

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知的障害者における口腔内状況と義歯使用状況の実態調査

米澤大輔, 石川裕子, 植木麻有子, 葭原明弘

日本歯科衛生学会雑誌 10 ( 1 ) 79 - 79 2015.8

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The relationship between oral health and medical expenditures among older adults

岩﨑正則, 葭原明弘, 宮﨑秀夫

8020 : はち・まる・にい・まる : 財団法人8020推進財団会誌 ( 14 ) 112 - 114 2015.1

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在宅高齢者における簡易嚥下状態評価(EAT-10)と栄養状態および栄養素摂取との関連

濱嵜朋子, 廣冨敏伸, 秋山理加, 岩崎正則, 邵仁浩, 粟野秀慈, 山田志麻, 巴美樹, 葭原明弘, 宮崎秀夫, 安細敏弘

口腔衛生学会雑誌 65 ( 2 ) 2015

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ブラッシング運動と歯垢除去効果の関連―歯科衛生士と一般成人の比較―

當摩紗衣, 大島邦子, 中島努, 野上有紀子, 早崎治明, 葭原明弘

新潟歯学会雑誌 44 ( 2 ) 129 - 129 2014.12

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N児童相談所一時保護児童の口腔内状況

野上有紀子, 葭原明弘, 大内章嗣, 高橋英樹, 早崎治明

障害者歯科 35 ( 4 ) 608 - 615 2014.10

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Streptococcus mutansのGtfB酵素C末端側におけるアミノ酸配列とう蝕との関連性

金子昇, 濃野要, 葭原明弘, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 64 ( 2 ) 207 - 207 2014.4

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The Factors Associated with Appetite and Chewing Difficulty in Community-dwelling Elderly People

HASHIMOTO Chikusa, YOSHIHARA Akihiro, MIYAZAKI Hideo

64 ( 3 ) 284 - 290 2014.4

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This study aimed to elucidate the relationships among subjective symptoms of "difficulty chewing" and appetite and other oral symptoms, social environmental factors, and nutritional intake. A questionnaire was sent to all 70-year-olds in Niigata City, and 600 subjects were randomly selected from among those interested in study participation. The number of teeth present was counted for intraoral assessment. The questionnaire was used to assess subjective oral symptoms as well as the Health Practice Index (HPI) based on Breslow's seven health habits. A face scale was used for QOL assessment such as the daily general condition, and interactions with family and friends and the presence or absence of a spouse were assessed as social factors. The nutritional status was evaluated by a dietician using a semiquantitative food frequency questionnaire. The intake of total calories, carbohydrates, fats, and proteins was calculated using a formula. A blood sample was collected for the measurement of serum albumin, total protein, and total cholesterol levels. For statistical analysis, the relationships among each factor and appetite and chewing difficulty were examined by multiple logistic regression analysis. Subjects with a good appetite had satisfactory relationships with family and friends (odds ratio: 3.19, p=0.001), and a more favorable general condition (odds ratio: 2.07, p=0.036). Subjects without difficulty chewing had more teeth (odds ratio: 1.04, p=0.001), no symptoms such as toothache (odds ratio: 0.16-0.58, p<0.0001-0.029), and satisfactory relationships with family and friends (odds ratio: 2.12, p=0.049). In conclusion, appetite and chewing difficulty may be associated with social factors and the overall health, such as QOL.

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「生活歯援プログラム」指導担当者への質問紙調査の結果から

小松崎明, 小野幸絵, 佐藤徹, 土屋信人, 有松美紀子, 山田智子, 八木稔, 荒井節男, 葭原明弘, 清田義和, 安藤雄一

口腔衛生学会雑誌 64 ( 1 ) 41 - 41 2014.1

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高齢者における歯・口腔の健康と全身の健康の関連に関する医療費分析調査 (8020推進財団指定研究事業報告)

岩﨑正則, 葭原明弘, 宮﨑秀夫

8020 : はち・まる・にい・まる : 財団法人8020推進財団会誌 ( 13 ) 111 - 113 2014.1

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政策声明う蝕のない社会の実現に向けて

安藤雄一, 川崎浩二, 内藤徹, 坂本友紀, 葭原明弘, 牧茂, 花田信弘, 杉山精一, 豊島義博, 日本口腔衛生学会政策声明委員会

口腔衛生学会雑誌 63 ( 5 ) 399 - 411 2013.10

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政策声明「う蝕のない社会の実現に向けて(仮称)」の作成について

安藤雄一, 牧茂, 川崎浩二, 内藤徹, 葭原明弘, 坂本友紀, 青山旬, 花田信弘, 豊島義博, 杉山精一

口腔衛生学会雑誌 63 ( 2 ) 213 - 213 2013.4

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高齢者における歯・口腔の健康と全身の健康の関連に関する医療費分析調査

葭原明弘, 岩崎正則, 宮崎秀夫

8020: はち・まる・にい・まる ( 12 ) 102 - 103 2013.1

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RELATIONSHIP BETWEEN DIETARY ENERGY DENSITY AND 5-YEAR AGING IN HEALTHY FREE-LIVING JAPANESE ELDERLY

M. Aki, R. Watanabe, K. Muramatsu, A. Yoshihara, H. Miyazaki

ANNALS OF NUTRITION AND METABOLISM 63 591 - 591 2013

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食事秤量調査による日本人高齢者のエネルギーおよび栄養素摂取量とポーションサイズ(特別セッション世論調査(生活の質))

村松芳多子, 渡邊令子, 佐々木敏, 葭原明弘, 宮崎秀夫

日本行動計量学会大会発表論文抄録集 40 109 - 110 2012.9

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Association between periodontitis and systemic bone mineral density in Japanese community-dwelling postmenopausal women (vol 40, pg 304, 2012)

Osamu Takahashi, Akihiro Yoshihara, Kazutoshi Nakamura, Hideo Miyazaki

JOURNAL OF DENTISTRY 40 ( 8 ) 700 - 701 2012.8

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DOI： 10.1016/j.jdent.2012.04.021

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口腔の健康と全身の健康 : 新潟高齢者研究の結果から

宮﨑秀夫, 葭原明弘, 岩崎正則

日本歯科衛生学会雑誌 7 ( 1 ) 24 - 34 2012.8

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Streptococcus mutansのGtfB酵素C末端側におけるアミノ酸配列と非水溶性グルカン合成能

金子昇, 濃野要, 葭原明弘, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 62 ( 2 ) 242 - 242 2012.4

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座談会地域住民と進める新8020運動 : 生きるを支える歯科医療を目指して (KEEP 20TEETH TILL YOUR 80)

深井穫博, 佐藤徹, 葭原明弘

8020 : はち・まる・にい・まる : 財団法人8020推進財団会誌 ( 11 ) 32 - 46 2012.1

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Relationships between the Number of Chewing Strokes during Mastication and Physique in Adults and the Elderly

IWASAKI Masanori, YOSHIHARA Akihiro, MIYAZAKI Hideo

61 ( 5 ) 563 - 572 2011.10

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This study, using the number of chewing strokes during mastication before the first swallowing as an index, investigated the relationships between the number of chewing strokes during mastication and physique in adults and the elderly, and clarified the age differences associated with the above relationships. The study involved 614 subjects (230 males and 384 females) who participated in a survey conducted in Joetsu City, Japan in 2009 and 2010. Rice crackers were used to measure the number of chewing strokes during mastication, and the subjects were divided into the following 3 groups based on the number of chewing strokes: <24, 25 to 30, and >31 strokes. From the results of body measurement, the subjects were defined as showing an accumulation of visceral fat (male: waist circumference ≥85cm or waist circumference <85cm and BMI≥25kg/m^2, female: waist circumference ≥90cm or waist circumference <90 and BMI≥25kg/m^2), obesity (BMI≥25kg/m^2), and thinness (BMI<18kg/m^2). The subjects were then categorized by age (adults: 20-64 years old, elderly: 65-89 years old) and gender. The relationships between the number of chewing strokes during mastication and physique were evaluated employing logistic regression analysis. The primary outcomes of the analysis were an accumulation of visceral fat, obesity, and thinness. The principal exposure variable included the number of chewing strokes during mastication (3 categories). Tested potential confounders included the number of teeth present and a smoking habit. Using the group with 25-30 strokes as a referent group, adult males in the groups with ≤24 and ≥31 strokes showed significantly high odds ratios (ORs) for visceral fat accumulation (OR [95% confidence interval]=6.89 [1.63-29.1], and OR=6.17 [1.39-27.3], respectively). Adult males in the two groups also showed significantly high ORs for obesity (OR [95% confidence interval]=7.33 [1.42-37.8] and OR=8.09 [1.50-43.7], respectively). Using the group with &kge;30 strokes as a referent group, elderly males in the group with ≥31 strokes showed a significant high OR for thinness (OR [95% confidence interval]=5.76 [1.17-28.4]). The study results suggest that the relationships between the number of chewing strokes during mastication and physique differ in adults and elderly males.

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Streptococcus mutans臨床分離株のgtfB遺伝子における直列反復配列と非水溶性グルカン合成能

金子昇, 濃野要, 葭原明弘, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 61 ( 4 ) 508 - 508 2011.8

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新潟高齢者スタディー

宮崎秀夫, 葭原明弘

8020 ( 10 ) 90 - 95 2011.1

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早食いと咀嚼の自覚の関連 Web調査による検討

安藤雄一, 石濱信之, 青山旬, 深井穫博, 三浦宏子, 佐藤加代子, 葭原明弘, 古田美智子, 木村年秀, 森田学, 佐藤眞一, 花田信弘

日本公衆衛生学会総会抄録集 69回 527 - 527 2010.10

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日本人高齢者における下顎骨下縁と骨強度との関係(Relationship between the mandibular inferior cortex and bone stiffness in elderly Japanese people)

Kiswanjaya Bramma, Yoshihara Akihiro, Deguchi Tomoya, Hanada Nobuhiro, Miyazaki Hideo

新潟歯学会雑誌 40 ( 1 ) 99 - 99 2010.6

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The relationship between antiinflammatory / antioxidant nutrients and periodontal disease

Iwasaki Masanori, Yoshihara Akihiro, Miyazaki Hideo

40 ( 1 ) 85 - 86 2010.6

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口腔保健と全身のQOLの関係に関する総合研究高齢者の口腔保健と全身的な健康状態の関係についての追跡調査

宮崎秀夫, 葭原明弘, 西牟田守, 吉武裕, 渡邊令子, 木村靖夫, 大橋正春, 野村修一, 高田豊, 島田美恵子, 田中宏暁, 林孝文, 渡邊智子, 泉福英信, 小林博, 西山秀昌, 五十嵐敦子, 中川直樹, 安細敏弘, 村松芳多子, 佐久間汐子, 田中みか子, 廣富敏伸, 金子昇, 濃野要, 佐藤直子, 櫻井直樹, 小山純一, 田中礼, 小川祐司, 山賀孝之, 高野尚子, 伊藤加代子, 綾部誠也, 飛奈卓郎, 安藝真理子, 船山さおり, 昆はるか, 甲斐朝子, 金城篤史

口腔保健と全身のQOLの関係に関する総合研究平成21年度総括・分担研究報告書 33 - 49 2010

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血清および唾液中抗Porphyromonas gingivalis抗体価と冠動脈性心疾患リスク因子との関連性の検討

金子昇, 濃野要, 今井奨, 葭原明弘, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 59 ( 4 ) 496 - 496 2009.8

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フッ化物洗口の都道府県別にみた普及の推移国の政策が果たした役割の検討

田浦勝彦, 相田潤, 安藤雄一, 晴佐久悟, 田口千恵子, 木本一成, 葭原明弘, 筒井昭仁, 眞木吉信, 荒川浩久, 飯島洋一, 磯崎篤則, 小林清吾, 小関健由

口腔衛生学会雑誌 59 ( 4 ) 516 - 516 2009.8

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口腔保健と全身のQOLの関係に関する総合研究「骨代謝マーカーと歯周病および下顎骨形態との関係について」

葭原明弘, 出口知也, 宮崎秀夫, 花田信弘

口腔保健と全身のQOLの関係に関する総合研究平成20年度総括研究報告書 2009

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口腔保健と全身のQOLの関係に関する総合研究「日本人高齢者における血中TNF-αと口腔健康状態」

宮崎秀夫, 林田秀明, 齋藤俊行, 山口登, 葭原明弘, 小川祐司

口腔保健と全身のQOLの関係に関する総合研究平成20年度総括研究報告書 2009

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The health power of teeth: The relationship between diet intake and nutrition and periodontal disease

Food style 21 12 ( 10 ) 21 - 23 2008.10

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血清アルブミンと歯周病の関係についての経年的評価

岩崎正則, 葭原明弘, 廣冨敏伸, 小川祐司, 花田信弘, 宮崎秀夫

新潟歯学会雑誌 38 ( 1 ) 46 - 46 2008.6

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Association between oral health status and serum albumin

Yoshihara Akihiro, Iwasaki Masanori, Miyazaki Hideo

37 ( 2 ) 209 - 210 2007.12

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Vitamin D status, bone mass, and bone metabolism in postmenopausal Japanese women

K. Nakamura, N. Tsugawa, T. Saito, Y. Tsuchiya, A. Yoshihara, T. Okano, M. Yamamoto

JOURNAL OF BONE AND MINERAL RESEARCH 22 S342 - S342 2007.9

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高齢者の口腔健康と精神健康との関連

高野尚子, 葭原明弘, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 57 ( 4 ) 551 - 551 2007.8

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高齢者における唾液中抗PAc(361-386)IgA抗体と根面齲蝕との関連

金子昇, 葭原明弘, 泉福英信, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 57 ( 4 ) 422 - 422 2007.8

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Preliminary study on the effect of oral care on recovery from surgery in elderly patients (vol 33, pg 820, 2006)

M. Sato, A. Yoshihara, H. Miyazaki

JOURNAL OF ORAL REHABILITATION 34 ( 1 ) 77 - 77 2007.1

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DOI： 10.1111/j.1365-2842.2007.01721.x

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地域住民の口腔保健と全身的な健康状態の関係についての総合研究高齢者の口腔保健と全身的な健康状態の関係についての追跡調査

宮崎秀夫, 葭原明弘, 西牟田守, 吉武裕, 渡邊令子, 木村靖夫, 大橋正春, 島田美恵子, 前田伸子, 田中宏暁, 泉福英信, 五十嵐敦子, 中川直樹, 佐久間汐子, 金子昇, 濃野要, 佐藤直子, 廣富敏伸, 小川祐司, 山賀孝之, 伊藤加代子, 高野尚子, 出口知也, 船山さおり, 渡部守, 人見康正, 綾部誠也, 飛奈卓郎, 樋口博之, 永山寛, 濱岡隆文

地域住民の口腔保健と全身的な健康状態の関係についての総合研究平成18年度総括研究報告書 22 - 166 2007

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高齢者の軽度血中副甲状腺ホルモン濃度上昇は骨量低下を促進するか?-横越研究結果より-

中村和利, 津川尚子, 斎藤トシ子, 土屋康雄, 葭原明弘, 岡野登志夫, 山本正治

Osteoporosis Japan 15 2007

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遺伝子診断によるスクリーニングと予防戦略

葭原明弘, 高橋収, 宮秀夫

ザ・クインテッセンス 25 105 - 110 2006.12

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新潟市の歯科保健重点地域における住民協働の乳歯う蝕予防活動の報告 : グループインタビュー結果と取組み

坂口真弓, 岸洋志, 岡田匠, 葭原明弘

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 56 ( 4 ) 636 - 636 2006.8

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新潟市における市町村合併と歯科保健計画について

藤山友紀, 岸洋志, 岡田匠, 葭原明弘

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 56 ( 4 ) 635 - 635 2006.8

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日本における集団応用でのフッ化物洗口に関する実態調査(2006)

木本一成, 晴佐久悟, 浪越建男, 葭原明弘, 野上成樹, 田浦勝彦, 山内皓央, 安彦良一, 荒川浩久, 境脩

口腔衛生学会雑誌 56 ( 4 ) 584 - 584 2006.8

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Streptococcus mutans gtfB遺伝子の菌株による多様性とグルカン合成能の関係

金子昇, 葭原明弘, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 56 ( 4 ) 620 - 620 2006.8

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75歳自立高齢者におけるう蝕原因歯と歯周病,根面う蝕との関係

早乙女裕彦, 植松宏, 泉福英信, 多田章夫, 花田信弘, 葭原明弘, 宮崎秀夫

口腔病学会雑誌 73 ( 1 ) 148 - 148 2006.3

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地域住民の口腔保健と全身的な健康状態の関係についての総合研究「高齢者の追跡調査」

宮崎秀夫, 葭原明弘, 西牟田守, 吉武裕, 渡邊令子, 木村靖夫, 大橋正春, 島田美恵子, 前田伸子, 田中宏暁, 泉福英信, 五十嵐敦子, 佐藤七枝, 中川直樹, 山賀孝之, 廣富敏伸, 小川祐司, 綾部誠也, 飛奈卓郎, 樋口博之, 永山寛, 濱岡隆文, 小城明子, 今井奨, 渡邊智子, 鈴木亜夕帆, 出口知也, 近藤隆子, 船山さおり, 渡部守, 人見康正

地域住民の口腔保健と全身的な健康状態の関係についての総合研究平成17年度総括・分担研究報告書 19 - 165 2006

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乳幼児歯科健診受診児の母親を対象とした全国歯科保健実態調査う蝕有病状況に関する報告

安藤雄一, 中垣晴男, 宮崎秀夫, 葭原明弘, 荒川浩久, 飯島洋一, 川崎浩二, 井後純子, 杉本智子, 渡辺晃子, 重政昭彦, 鳥山佳則, 田口円裕

口腔衛生学会雑誌 56 ( 4 ) 461 - 461 2006

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歯科保健における予防プログラムと健康日本21

八木稔, 宮秀夫, 川口陽子, 佐久間汐子, 葭原明弘

学校保健研究 46 601 - 602 2005.12

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Is the bone mineral density a risk factor for periodontal disease progression?

Akihiro Yoshihara, Yoshikazu Seida, Nobuhiro Hanada, Hideo Miyazaki

Dental Tribune No.2 Vol3 5 2005.12

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齲蝕原性菌および歯周病原性菌の母子間の伝達

金子昇, 葭原明弘, 宮秀夫

新潟歯学会誌 35 59 - 61 2005.12

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高齢者の咀嚼能力と日常生活動作遂行能力との関連性

清田義和, 葭原明弘, 小川祐司, 廣冨敏伸, 山賀孝之, 高野尚子, 片岡照二郎, 濃野要, 宮崎秀夫

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 54 ( 4 ) 354 - 354 2004.8

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フッ化物洗口法によるう蝕予防効果の成人期における追跡調査

葭原明弘, 佐久間汐子, 峯田和彦, 高徳幸男, 田村卓也

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 54 ( 4 ) 314 - 314 2004.8

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歯周疾患における S. mutans の歯表面付着阻害抗体の意義

泉福英信, 多田章夫, 津覇雄三, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 54 ( 4 ) 327 - 327 2004.8

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ミュータンスレンサ球菌分離株のグルカン合成能とう蝕との関連

金子昇, 葭原明弘, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 54 ( 4 ) 442 - 442 2004.8

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日本における集団応用でのフッ化物洗口に関する実態調査

木本一成, 晴佐久悟, 山本武夫, 葭原明弘, 藤野悦男, 志村匡代, 田浦勝彦, 磯崎篤則, 荒川浩久, 小林清吾, 境脩

口腔衛生学会雑誌 54 ( 4 ) 420 - 420 2004.8

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The relationship between dental diseases and nutrient values in the elderly

A Yoshihara, R Watanabe, M Nishimuta, N Hanada, H Miyazaki

JOURNAL OF DENTAL RESEARCH 82 424 - 424 2003.12

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診査部位数減少による歯周病進行率の過小評価に関する研究

廣冨敏伸, 葭原明弘, 小川祐司, 山賀孝之, 高野尚子, 清田義和, 宮崎秀夫

口腔衛生学会雑誌 53 ( 4 ) 401 - 401 2003.8

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新潟市における成人歯科健診に関する考察

岸洋志, 岡田匠, 葭原明弘, 出口知也, 宮崎秀夫

口腔衛生学会雑誌 53 ( 4 ) 408 - 408 2003.8

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フッ化物洗口と選択的シーラント応用による複合プログラムの費用効果分析

佐久間汐子, 葭原明弘, 八木稔, 宮崎秀夫

口腔衛生学会雑誌 53 ( 4 ) 388 - 388 2003.8

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萌出から5年間の第一大臼歯咬合面小窩の電気抵抗値変化

片岡照二郎, 佐久間汐子, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 53 ( 4 ) 485 - 485 2003.8

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市町村における歯科保健計画策定の支援を目的としたモデル調査事業の有用性

安藤雄一, 高徳幸男, 峯田和彦, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 53 ( 4 ) 420 - 420 2003.8

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住民参加型地域保健活動事業におけるNPO法人との連携に関する研究

石井拓男, 池主憲夫, 米満正美, 岡田眞人, 安藤雄一, 大内善嗣, 坂井剛, 武者良憲, 野村義明, 葭原明弘

口腔衛生学会雑誌 53 ( 4 ) 440 - 440 2003.8

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歯学教育プログラムへのPBL教育の導入南カリフォルニア大学歯学部における実態調査

小野和宏, 前田健康, 花田晃治, 山田好秋, 高木律男, 興地隆史, 魚島勝美, 葭原明弘, 永田昌毅, 安島久雄

日本歯科医学教育学会総会・学術大会プログラム・抄録集 22回 52 - 52 2003.7

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新潟大学歯学部卒前教育へのOSCEの導入(第2報) コミュニケーション能力の評価

興地隆史, 福島正義, 葭原明弘, 田井秀明, 高田佳之, 小野和宏, 小林博, 魚島勝美, 富沢美恵子, 高木律男, 前田健康, 山田好秋, 花田晃治

日本歯科医学教育学会総会・学術大会プログラム・抄録集 22回 41 - 41 2003.7

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高齢者歯科学への学際的アプローチ

葭原明弘, 清田義和, 小川祐司, 高野尚子, 廣富敏伸, 山賀孝之, 金子昇, 佐久間汐子, 八木稔, 宮崎秀夫

新潟歯学会雑誌 33 ( 1 ) 1 - 9 2003.7

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A study on oral Candida and its correlation with oral status in elderly people.

J. Wang, T. Ohshima, U. Yasunari, S. Namikoshi, A. Yoshihara, H. Miyazaki, N. Maeda

JOURNAL OF DENTAL RESEARCH 82 B135 - B135 2003.6

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Risk factors for tooth loss among elderly people in Japan.

Y. Seida, A. Yoshihara, H. Miyazaki

JOURNAL OF DENTAL RESEARCH 82 B206 - B206 2003.6

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A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults.

A. Yoshihara, N. Hanada, H. Miyazaki

JOURNAL OF DENTAL RESEARCH 82 B38 - B38 2003.6

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Influence of tobacco smoking and the serum level of vitamin C on periodontal disease in elderly patients.

H. Ogawa, A. Yoshihara, N. Amarasena, H. Miyazaki

JOURNAL OF DENTAL RESEARCH 82 B362 - B362 2003.6

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新潟市高齢者コホート調査(新潟スタディ)からみた歯と全身の健康

葭原明弘, 宮崎秀夫

8020(財団法人8020推進財団・会誌) 1 53 - 56 2002.12

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健常高齢者の歯周組織健康状態およびその経年変化に関する研究

廣富敏伸, 葭原明弘, 宮崎秀夫

新潟歯学会雑誌 32 17 - 18 2002.12

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小学校でフロスを教えよう!小学校におけるデンタルフロスを使用した歯肉炎予防プログラムについて

深井浩一, 葭原明弘, 森山俊次, 堀川敏子, 両角祐子, 廣富敏伸, 宮崎秀夫

日本歯科評論 62 131 - 137 2002.12

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小学校におけるデンタルフロスを用いた保健指導による歯肉炎の改善-18ヶ月後の評価

葭原明弘, 深井浩一, 両角祐子, 廣富俊伸, 宮崎秀夫

口腔衛生学会雑誌 52 ( 4 ) 394 - 395 2002.8

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新潟大学歯学部卒前教育へのOSCEの導入

興地隆史, 福島正義, 葭原明弘, 子田晃一, 小野和宏, 小林博, 魚島勝美, 小山純市, 植田耕一郎, 高木律男, 前田健康, 花田晃治

日本歯科医学教育学会総会・学術大会プログラム・抄録集 21回 52 - 52 2002.7

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Relationship between lifestyle and periodontal destruction among Japanese elderly people.

T Hirotomi, A Yoshihara, H Miyazaki

JOURNAL OF DENTAL RESEARCH 81 A370 - A370 2002.3

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A study of preventive program for gingivitis using dental floss in elementary school

Hiroki Yuko, Fukai Koichi, Yoshihara Akihiro, Hirotomi Toshinobu, Miyazaki Hideo, Hasegawa Akira

Journal of the Japanese Association of Periodontology 43 181 - 181 2001.9

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フッ化物洗口法と歯科医療費に関する調査

峯田和彦, 安藤雄一, 高徳幸男, 葭原明弘, 瀧口徹, 宮崎秀夫

口腔衛生学会雑誌 51 ( 4 ) 644 - 645 2001.9

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地域歯科保健ベースでのシーラントプログラムの評価

葭原明弘, 王晶, 佐久間汐子, 峯田和彦, 宮崎秀夫

口腔衛生学会雑誌 51 ( 4 ) 384 - 385 2001.9

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在宅要介護者への訪問歯科健診診療事業の評価

岸洋志, 渡部純子, 石川鋭一, 葭原明弘, 片岡照二郎, 藤山友紀, 宮崎秀夫

口腔衛生学会雑誌 51 ( 4 ) 698 - 699 2001.9

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フッ化物洗口実施小学校と未実施小学校におけるミュータンスレンサ球菌の検出率及び齲蝕との関連

金子昇, 今井奨, 西沢俊樹, 葭原明弘, 佐久間汐子, 宮崎秀夫, 花田信弘

口腔衛生学会雑誌 51 ( 4 ) 642 - 643 2001.9

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日本人小学生におけるミュータンスレンサ球菌の検出率および歯牙齲蝕との関連

金子昇, 井田博久, 今井奨, 西沢俊樹, 葭原明弘, 佐久間汐子, 宮崎秀夫, 花田信弘

日本細菌学雑誌 56 ( 1 ) 334 - 334 2001.2

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新潟市在住の高齢者276人の血清中の炎症性サイトカイン濃度と口腔健康状態との関連性

村田貴俊, 葭原明弘, 安藤雄一, 泉福英信, 花田信弘, 宮崎秀夫

口腔衛生学会雑誌 51 ( 1 ) 131 - 131 2001.1

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フッ化物洗口実施小学校と非実施小学校における口腔内細菌と齲蝕の調査

金子昇, 今井奨, 西沢俊樹, 葭原明弘, 佐久間汐子, 宮崎秀夫, 花田信弘

口腔衛生学会雑誌 50 ( 4 ) 442 - 443 2000.9

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う蝕有病と唾液中mutans streptococciおよびlactobacilliレベルとの関連性

葭原明弘, 佐久間汐子, 王晶, 宮崎秀夫

口腔衛生学会雑誌 50 ( 4 ) 444 - 445 2000.9

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学童におけるフッ化物配合歯磨剤の効果的な使用方法について

根子淑江, 葭原明弘, 佐久間汐子, 王晶, 宮崎秀夫

口腔衛生学会雑誌 50 ( 4 ) 616 - 617 2000.9

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The Study of Sampling Bias in an Oral Health Survey of Elderly : Comparison of Oral and General Health Condition between Respondents and Non-Respondents to a Questionnaire and between Participants and Non-Participants in an Examination

ANDO Yuichi, YOSHIHARA Akihiro, SEIDA Yoshikazu, HIROTOMI Toshinobu, OGAWA Hiroshi, KANEKO Noboru, TAKANO Naoko, YAMAGA Takayuki, WANG Jing, KANMORI Hideki, KISHI Hiroshi, HANADA Nobuhiro, MIYAZAKI Hideo

50 ( 3 ) 322 - 333 2000.7

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The purpose of this study was to evaluate sampling bias caused by present teeth or general health condition in an oral health survey of elderly subjects. A mailed questionnaire survey was carried out for residents of Niigata City who were 70 or 80 years old, investigating the number of present teeth, general health condition and intention to participate in an oral examination. Follow-up mailings were sent once to non-respondents. The response rate was increased from 60.4% to 79.5% by the follow-up mailing. A telephone survey was carried out for subjects who didn't answer the questionnaire. ...

DOI： 10.5834/jdh.50.3_322

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Antimicrobial effect of fluoride mouthrinse on mutans streptococciand lactobacilli in saliva

Akihiro Yoshihara, Shihoko Sakuma, Hideko Miyazaki

Niigata dental journal 30 ( 1 ) 77 - 78 2000.7

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Association between serum albumin and untreated teeth

A Yoshihara, Y Ando, H Miyazaki

JOURNAL OF DENTAL RESEARCH 79 ( 5 ) 1241 - 1241 2000.5

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ミュータンスレンサ球菌と歯牙齲蝕との関連

金子昇, 井田博久, 今井奨, 西沢俊樹, 葭原明弘, 佐久間汐子, 宮崎秀夫, 花田信弘

日本細菌学雑誌 55 ( 2 ) 209 - 209 2000.4

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フッ化物洗口集団とコントロール集団における齲蝕ハイリスク児のプレディクターの差異

佐久間汐子, 葭原明弘, 王晶, 宮崎秀夫, 松村誠士, 下野勉

口腔衛生学会雑誌 49 ( 4 ) 686 - 687 1999.9

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診療室での予防処置に関する全国13道県の実態調査

葭原明弘, 安藤雄一, 八木稔, 宮崎秀夫, 池主憲夫, 坂井剛, 箱崎守男, 佐藤保

口腔衛生学会雑誌 49 ( 4 ) 748 - 749 1999.9

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高齢者の現在歯数が栄養摂取に及ぼす影響

神森秀樹, 葭原明弘, 安藤雄一, 小川祐司, 高野尚子, 廣富敏伸, 山賀孝之, 宮崎秀夫, 花田信弘

口腔衛生学会雑誌 49 ( 4 ) 728 - 729 1999.9

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高齢者の根面う蝕と歯冠う蝕の有病状況

高野尚子, 安藤雄一, 小川祐司, 廣富敏伸, 山賀孝之, 葭原明弘, 宮崎秀夫, 花田信弘

口腔衛生学会雑誌 49 ( 4 ) 612 - 613 1999.9

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Duration Needs Careful Maintenance for Fissure-sealed Teeth in Schoolchildren using Regular Fluoride Mouth Rinse

SAKUMA Shihoko, YOSHIHARA Akihiro, KOBAYASHI Seigo, MIYAZAKI Hideo

49 ( 2 ) 178 - 185 1999.4

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The purpose of this study was to evaluate longitudinally the retention of fissure sealants applied to first permanent molars with sticky fissures in order to grasp the appropriate period for maintenance of sealants. 0ne hundred sixty seven schoolchildren aged between 11 and 14 years were investigated in this study. These subjects participated in a school-based fluoride mouthrinse program, combined with a targeted fissure sealant for 5 to 6 years. In the sealant program, they received a light-cured sealant on only the surfaces whose fissures could be detected as "sticky" using an explorer. Two hundred seventy three sealed teeth, which were done in subjects between the ages of 6-9 years, and which had gone more than 4 years since the initial treatment, were analyzed. Teeth and sealant conditions were assessed regularly twice a year in elementary school and once a year in junior high school by calibrated examiners. Sealant replacements, if needed, were done only for elementary schoolchildren. The total retention rate of sealants was 88.6% during the survey periods, which included completely intact sealant (69.6%) and replaced intact sealant (19.0%). The failure rate of sealants, which were revealed because of occurring dental decay or restoration due to decay, was 9.9%. Using survival analysis (Kaplan-Meier survivor functions), the cumulative retention rates for initial and replacement sealants were found to be 68.3±3.2 (SE)% after 8 years and 67.2±7.9 (SE)% after 6 years, respectively. Statistically significant difference was not found (generalized Wilcoxon analysis) between the cumulative retention rate of the initial sealant and replacement. In both initial and replacement sealants, the cumulative retention rates gradually decreased up to 3 years. After that, there was a charge from a slight decrease to a stable condition according to follow-up periods. 0f all the cases in which initial sealants dropped out, 77.1% were observed in under 4 years. All the decayed or restored (because of caries) teeth, except one, were found within 4 years of the fissures being sealed. These results indicate that the probability of resealing needs and of occurring caries reduces in sealants more than 4 years old. Therefore, the results suggest that the period of 4 years should be addressed as the appropriate period for maintenance of sealants.

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The Evaluation of Reasonable Adaptation of Pit and Fissure Sealant Using Clinical Decision Analysis

YOSHIHARA Akihiro, SAKUMA Shihoko, MIYAZAKI Hideo

Dentistry in Japan 35 84 - 86 1999.3

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Economic Aspects of Pit and Fissure Sealant

Akihiro Yoshihara, Shihoko Sakuma

Niigata dental journal 28 ( 2 ) 81 - 82 1998.12

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成人歯科保健における歯科健康診査と健康教育の有効性

葭原明弘, 八木稔, 金子昇, 澤村恵美子, 宮崎秀夫

口腔衛生学会雑誌 48 ( 4 ) 454 - 455 1998.9

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視診, う蝕検知液, ECMの咬合面う蝕に対する診断能力について-組織学的所見との比較: in vitro study-

王晶, 佐久間汐子, 葭原明弘, 小林清吾, 宮崎秀夫

口腔衛生学会雑誌 48 ( 4 ) 562 - 563 1998.9

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現在歯数と歯の動揺との関連

斉藤尚子, 安藤雄一, 清田義和, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 48 ( 4 ) 512 - 513 1998.9

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Microbiologic effect in schoolchildren using fluoride mouthrinse

A Yoshihara, S Sakuma, S Kobayashi, H Miyazaki

JOURNAL OF DENTAL RESEARCH 77 841 - 841 1998

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The Prevalence of Dental Caries and Pit and Fissure Sealant in theFirst Molar

Akihiro Yoshihara, Takeshi Sasaki, keiko Ota

Niigata dental journal 27 ( 2 ) 13 - 16 1997.12

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Other Link： http://search.jamas.or.jp/link/ui/1998132944
Latest Achieved Epidemiologic Model of Maximum Caries Prevention

Seigo KOBAYASHI, Shihoko SAKUMA, Akihiro YOSHIHARA

Niigata dental journal 27 ( 2 ) 221 - 222 1997.12

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スティッキーフィッシャーに応用したシーラントの予後評価-3〜8年間の追跡調査-

佐久間汐子, 葭原明弘, 小林清吾, 宮崎秀夫

口腔衛生学会雑誌 47 ( 4 ) 436 - 437 1997.9

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シーラント填塞法の便益性に関する研究

葭原明弘, 佐久間汐子, 宮崎秀夫

口腔衛生学会雑誌 47 ( 4 ) 434 - 435 1997.9

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Dental Caries Prevalence in 12-year-old Children in Shenyang, China

Jing Wang, Shihoko Sakuma, Akihiro Yoshihara

Niigata dental journal 27 ( 1 ) 15 - 18 1997.7

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Retention Rate of Pit and Fissure Sealant in Permanent First Molars Considered at High Caries Risk

YOSHIHARA Akihiro, SAKUMA Shihoko, KOBAYASHI Seigo, MIYAZAKI Hideo

46 ( 5 ) 729 - 733 1996.10

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The purpose of this study was to evaluate the retention rate of pit and fissure sealant on permanent 1st molars considered at high caries risk for 6 months up to 3 years. A total of 156 pits and fissures were screened according to 4 indices ; sticky fissure, occlusal plaque level, occlusal status and age. We sealed teeth with resin in 356 primary school children (1st-3rd grades ; 6-9 years old) who had been a school-hased fluoride mouthrinsing program since the age of 4. Retention rates were 75.9-100%, 69.0-96.8% and 58.6% after 6 months, 2 years, and 3 years, respectively. Salivary contamination during operation was the major reason for failure (lower percentages described above) according to multiple regression analysis. For 22 pits and fissures where sealants dropped out, re-sealing was conducted at regular check-ups twice a year. Dental caries was observed in only 4 pits and fissures out of 156 during the survey period. These results suggested that higher retention rate could be obtained by effective cleaning and preventing salivary contamination, even for sticky fissures which were considered at high caries risk.

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大学病院における予防歯科(口腔衛生科)診療の現状と機能

石川昭, 本多丘人, 稲葉大輔, 田浦勝彦, 小野澤裕彦, 佐野祥平, 葭原明弘, 村上多恵子, 森下真行

口腔衛生学会雑誌 46 ( 4 ) 388 - 389 1996.9

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Tooth Loss in a Population of Institutionalized Mentally Retarded Japanese

OGURO Akira, TANABE Yoshihiro, NODA Tadashi, YOSHIHARA Akihiro, MIYAZAKI Hideo

J. Dent. Health 46 ( 3 ) 346 - 352 1996.7

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Oral health status and cause of tooth loss were studied in 1060 mentally retarded individuals who were admitted and resided in an institute during the period of 1971-1988. Our study cohort comprised 7-14 % of the estimated total of profoundly to moderately retarded persons in the general population. The estimate was nearly 10 thousand among the approximately 2.5 million general population of Niigata Prefecture throughout 1971 to 1988. A higher mean tooth loss was associated with increasing age : 1.2 in 6-14-year-olds and 6.6 in 35-44-year-olds in the 1970's, and 0.7 in 6-14-year-olds and 9.1 in 45-54-year-olds in the 1980's. These values were approximately 2-4 times higher in all ages but more than 15 times in 6-14-year-olds and in the 1980's diminished a bit in 45-54-year-olds than the values in the general population. Age and caries experience (DMFT) have been statistically proved to be significant risk indicators or factors of severer tooth loss in all ages through the life of mentally retarded persons.

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Does a Long-Term Oral Health Program for Adults Based on Oral Health Examinations Contribute to Reduction of Tooth Loss?

YOSHIHARA Akihiro, ANDO Yuichi, IKEDA Satoshi, KOBAYASHI Seigo, OGURO Akira, ISHIGAMI Kazuo, NAGASE Yoshihiko, SAWAMURA Emiko, TAKIGUCHI Toru

46 ( 3 ) 339 - 345 1996.7

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The purpose of this study was to evaluate the value of the oral health program for adults which was regularly carried out by the local government on a community basis. An oral health survey was conducted for 1,311 persons living in Itakura-machi, Niigata Prefecture, which had population of 8,170 in 1994. Of these, 309 persons had participated in the program at least once before 1993 (experienced group). The others, 1,002 persons, had no experience of such a program (inexperienced group). The results from cross-sectional analysis in 1994 showed that the mean number of missing teeth in experienced groups was significantly fewer (p<0.05, 0.001) than in the inexperienced group in 55-59, 60-64 and 65-69-year olds, and the mean number of filled teeth in the experienced group was significantly greater (p<0.05, 0.01) than in the inexperienced group in 55-59 and 65-69-year olds. However, no significant differences were found in the mean number of decayed teeth and in the percentage of persons without untreated teeth between both groups in each age group. On the other hand, the longitudinal analysis, which showed no significant difference in the mean number of missing teeth between both groups, clearly indicated that oral health program based on examinations did not contribute to reduction of tooth loss. Therefore, for promoting or maintaining oral health the program should also include oral health instruction or education rather than only oral examinations.

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フッ化物洗口法とTargeted Sealantの複合応用によるう蝕予防管理-学校歯科診療室管理群の成績-

佐久間汐子, 小林清吾, 葭原明弘, 平川敬, 渡辺雄三, 峯田和彦, 堀井欣一

口腔衛生学会雑誌 45 ( 4 ) 560 - 561 1995.9

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A TARGETED SEALANT PROGRAM COMBINED WITH FLUORIDE MOUTHRINSING - 5-YEAR RESULTS

S KOBAYASHI, S SAKUMA, A YOSHIHARA, K HORII, O SAKAI, AM HOROWITZ

JOURNAL OF DENTAL RESEARCH 74 458 - 458 1995

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歯科健康診査を中心とした成人歯科保健事業がう蝕有病および喪失歯の状況に及ぼす影響について

葭原明弘

口腔衛生会誌 45 502 - 503 1995

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Dental Health Promotion in a Community with No Dentist : Benefits froma preventive program for dental caries in permanent teeth ofschoolchidren and problems with dental diseases in adults , inAwashimaura-Village, Niigata-Prefecture, Japan.

Kazuhiko MINETA, Akihiro YOSHIHARA, Minoru YAGI

Niigata dental journal 23 ( 2 ) 45 - 52 1993.12

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Benefits of a community oriented fluoride mouth rinsing program

YOSHIHARA A.

Japanese journal of public health 40 ( 11 ) p1054 - 1061 1993.11

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委員会報告日本人における歯周病のセルフレポートに関する文献レビュー

葭原明弘, 安細敏弘, 伊藤博夫, 佐々木健, 山本龍生

口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health 2017.7 日本口腔衛生学会

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高齢者のオーラルセルフケアフッ化物以外のセルフケアによるう蝕予防 (高齢者のオーラルセルフケアに関する学会提言)

葭原明弘, 山賀孝之

口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health 2017.4 日本口腔衛生学会

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Current status of tooth loss and relationship between the use of dentures and activities of daily living in individuals with mental retardation

2017.2

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The relationship between oral health and medical expenditures among older adults

2015.1

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高齢者における歯・口腔の健康と全身の健康の関連に関する医療費分析調査 (8020推進財団指定研究事業報告)

岩﨑正則, 葭原明弘, 宮﨑秀夫

8020 : はち・まる・にい・まる : 財団法人8020推進財団会誌 2014.1 8020推進財団

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O-10 地域在住女性高齢者における腎機能と歯周組織の炎症部位面積に関する横断調査(一般口演)

岩崎正則, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 2013.4 有限責任中間法人日本口腔衛生学会

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P-91 政策声明「う蝕のない社会の実現に向けて(仮称)」の作成について(ポスター)

安藤雄一, 牧茂, 川崎浩二, 内藤徹, 葭原明弘, 坂本友紀, 青山旬, 花田信弘, 豊島義博, 杉山精一

口腔衛生学会雑誌 2013.4 有限責任中間法人日本口腔衛生学会

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口腔衛生学における疫学研究のエビデンスとその応用(ポストドクトリアルセミナー)

八重垣健, 葭原明弘

口腔衛生学会雑誌 2013.4 有限責任中間法人日本口腔衛生学会

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歯科保健活動で「地域とつながる」ということ (特集歯科口腔保健を巡る話題)

葭原明弘

公衆衛生 2013.2 医学書院

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食事秤量調査による日本人高齢者のエネルギーおよび栄養素摂取量とポーションサイズ(特別セッション世論調査(生活の質))

村松芳多子, 渡邊令子, 佐々木敏, 葭原明弘, 宮崎秀夫

日本行動計量学会大会発表論文抄録集 2012.9 日本行動計量学会

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口腔の健康と全身の健康 : 新潟高齢者研究の結果から

宮﨑秀夫, 葭原明弘, 岩崎正則

日本歯科衛生学会雑誌 2012.8 日本歯科衛生学会

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The relationship between masticatory ability and assessment items of metabolic syndrome in adults aged 60's years old

Takahashi Junko, Yoshihara Akihiro, Hayami Ryu

2012.6

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座談会地域住民と進める新8020運動 : 生きるを支える歯科医療を目指して (KEEP 20TEETH TILL YOUR 80)

深井穫博, 佐藤徹, 葭原明弘

8020 : はち・まる・にい・まる : 財団法人8020推進財団会誌 2012.1 8020推進財団

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Association between Masticatory Performance and One-leg Standing Time with Eyes Open in Community-dwelling Elderly Women

IWASAKI Masanori, YOSHIHARA Akihiro, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 2012 Japanese Society for Oral Health

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The one-leg standing test has been widely practiced as an equilibrium function test in the elderly because of its simple evaluation method. Previous studies confirmed that those who cannot maintain a one-leg standing position with eyes open for 30 seconds had a significantly increased risk of falls. Falls in the elderly can cause fracture, gait disturbance, hospital admission, and death. Mean-while, the study results regarding oral function and physical strength in the elderly showed that the one-leg standing time and number of teeth present/occlusal support area are closely associated. A color-changeable chewing gum test for masticatory performance is a simple method that can evaluate a subject's masticatory performance in a short period of time. The results of this test show a significant correlation with the number of teeth present or occlusal support area. This study examined the association between masticatory performance using a color-changeable chewing gum and the one-leg standing time with eyes open in community-dwelling elderly women. The subjects were 138 women aged between 65 and 74 years who participated in the surveys conducted in 2009 and 2010, and consented t

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The Relationship between Articulation Function Evaluated by Oral Diadochokinesis and Speech Mechanism Disorder

SUGIMOTO Tomoko, YOSHIHARA Akihiro, ITO Kayoko, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 2012 Japanese Society for Oral Health

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 The present study aimed to clarify the relationship between speech mechanism impairment and articulation function using oral diadochokinesis (OD). Subjects comprised 29 patients (23 men, 6 women; mean age, 68.8±9.3 years) undergoing rehabilitation due to dysarthria who consented to participate. In addition to measuring the OD rate, speech mechanism assessment and three other tests were simultaneously conducted. Multiple linear regression analysis was used to investigate the relationship between the OD rate and results of speech and speech mechanism assessment and presence or absence of orofacial, eating, or deglutition disorders. The following items demonstrated a significant relationship with all of the the OD sounds /pa/ /ta/ /ka/. The speech assessment parameters of speech intelligibility and degree of speech naturalness revealed that the higher the OD rate, the more patients' speech was 'well understood' and 'completely natural' (standard partial regression coefficient (β)=0.42-0.71; p<0.001-0.037). The longest exhalation and maximum phonation time of the speech mechanism parameters showed that the higher the OD rate, the longer the duration (

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新潟高齢者スタディー

宮崎秀夫, 葭原明弘

8020 2011.1 8020推進財団

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The Effect of an Oral Health Care Program for Improving Oral Functions in Community-dwelling Elderly

Usunami Kiyomi, Takano Naoko, Yoshihara Akihiro, Miyazaki Hideo

2010.12

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The relationship between antiinflammatory / antioxidant nutrients and periodontal disease

Iwasaki Masanori, Yoshihara Akihiro, Miyazaki Hideo

2010.6

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Relationship between the Number of Masticatory Cycles and Estimated Food and Nutrient Intake in Elderly Japanese

IWASAKI Masanori, YOSHIHARA Akihiro, MURAMATSU Kanako, WATANABE Reiko, MIYAZAKI Hideo

2010.4

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Correlation between Oral Care and Fever in General Ward Patients

HORI Ryoko, TAKANO Naoko, YOSHIHARA Akihiro, MIYAZAKI Hideo

Japanese Journal of Infection Prevention and Control 2010.3 Japanese Society for Infection Prevention and Control

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  Many studies have examined the preventive effects of oral care provided by dental professionals against aspiration pneumonia in elderly nursing home residents who require care. However, few reports have evaluated routine oral care provided by nurses to inpatients. Therefore, we investigated the correlation between oral care provided to general ward patients and the incidence of fever and the detection of the etiologic agents of hospital-acquired pneumonia in the oral cavity in 69 inpatients, aged 40 years or older, who were admitted to four hospitals in Niigata and required assistance in oral care. The number and details of oral care procedures were recorded. The presence of Staphylococcus aureus, MRSA, and Pseudomonas aeruginosa in the oral cavity were quantified, and fevers of 37.5°C or higher over the previous week were recorded. The subjects were divided into two groups based on oral intake (oral intake and non-oral intake groups), and Fisher's direct probability test was used to compare their results. For the oral intake group, the incidence of fever and the detection rate of S. aureus were significantly lower for subjects who received oral

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Relationship between the Number of Masticatory Cycles and Estimated Food and Nutrient Intake in Elderly Japanese

IWASAKI Masanori, YOSHIHARA Akihiro, MURAMATSU Kanako, WATANABE Reiko, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 2010 Japanese Society for Oral Health

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The purpose of the present study was to investigate the relationship between the number of masticatory cycles and estimated food and nutrient intake in elderly Japanese. The subjects were 349 patients (182 males and 167 females) aged 75 years in Niigata prefecture who participated in a dental examination, measurement of masticatory cycles, and a brief-type self-administered diet history questionnaire (BDHQ) in 2003. In the measurement of masticatory cycles, patients were instructed to chew 2 pieces of rice cracker (a rice cracker 4cm in diameter was broken into 2 pieces). The number of masticatory cycles was counted by observing the movement of the mental region. The patients were asked to raise their hands upon initial swallowing, and the number of masticatory cycles before the first swallowing was used as the masticatory cycles. Food and nutrient intake was calculated using the program for BDHQ. The relationship between the masticatory cycles and estimated food and nutrient intake was evaluated using multiple linear regression analysis, after simultaneously adjusting for sex, body mass index (BMI), smoking status, the number of teeth present, the usage of dentures, and masticator

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Change in Conditions Affecting the Regional Spread of School-based Fluoride Mouth Rinsing : Study on the Role of National Policy

TAURA Katsuhiko, ARAKAWA Hirohisa, IIJIMA Youichi, ISOZAKI Atsunori, KOBAYASHI Seigo, KOSEKI Takeyoshi, AIDA Jun, ANDOU Yuichi, HARESAKU Satoru, TAGUCHI Chieko, KIMOTO Kazunari, YOSHIHARA Akihiro, TSUTSUI Akihito, MAKI Yoshinobu

JOURNAL OF DENTAL HEALTH 2010 Japanese Society for Oral Health

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In January 2003, the Ministry of Health, Labour and Welfare notified the prefectural governors of the guideline on fluoride mouth-rinsing, including a recommendation that a school-based fluoride mouth-rinsing program be implemented to prevent and control dental caries in children. "Health Japan 21", a set of objectives for health promotion in the period 2001-2010, including the target of dental health, and the "8020 Movement," a special program to help people to keep 20 or more of their own teeth until the age of 80, had been developed before notification of this guideline. We examined how these national policies have impacted the spread of the school-based fluoride mouth-rinsing program among prefectures. A total of 674,141 children participated in the program in the 2008 survey, and about one-fourth of the prefectures have increased the rate of school-based fluoride mouth rinsing since the implementation of these strategies. Multilevel analysis was applied using the survey year as level 1 and prefectural variation as level 2 based on the rate of prefectural school-based fluoride mouth rinsing from 1994 to 2008 as an objective variable, and significant differences were recognized

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The Effects of Medication and Psychological Well-being on Subjective Oral Dryness in the Elderly

FUNAYAMA Saori, ITO Kayoko, NOHNO Kaname, IGARASHI Atsuko, INOUE Makoto, YOSHIHARA Akihiro, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH 2010 Japanese Society for Oral Health

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Language：Japanese Presentation type：Oral presentation (general)

Objective: One of the main causes of subjective oral dryness in the elderly is the side effects of medication. In addition, the elderly's tolerance to stress is low, and stress may induce many symptoms including mouth dryness. Thus, it is necessary to examine their psychological well-being. However, few reports have considered the relationship between subjective oral dryness and psychological well-being. Furthermore, few reports have examined subjective oral dryness, medication use, and psychological well-being simultaneously. The purpose of this study was to investigate the rate of subjective oral dryness and effects of psychological well-being and medication in the elderly. Methods: A questionnaire survey and interview concerning subjective oral dryness, medication use, and psychological symptoms were conducted involving 398 elderly aged 77-78 years old in Japan. The rates of the side effect of subjective oral dryness caused by medication and drug efficacy were investigated using the book 'Drugs in Japan'. The Japanese version of a general health questionnaire (GHQ 30), a self-entry type questionnaire, was used to evaluate psychological well-being. The elderly with scores greater

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フッ化物洗口プログラムをベースとした選択的シーラント応用の20歳成人におけるう蝕予防効果

中村文, 佐久間汐子, 葭原明弘, 八木稔, 出口知也, 宮崎秀夫

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 2006.8

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Language：Japanese Presentation type：Oral presentation (general)

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Reliability and Validity of Global Ratings for Competency Assessment : An Analysis of and OSCE at Niigata University Faculty of Dentistry

OKIJI Takashi, FUKUSHIMA Masayoshi, YOSHIBA Kunihiko, KOBAYASHI Hiroshi, YOSHIHARA Akihiro, HOSHINA Hideyuki, TOMIZAWA Mieko, TAKAGI Ritsuo, MAEDA Takeyasu, YAMADA Yoshiaki

2004.12

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Language：Japanese Presentation type：Oral presentation (general)

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Works

学童に対するリスク診断に基づく歯肉炎予防管理プログラムの構築

2007.12

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2010.12

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葭原明弘,歯肉炎予防プログラムの開発

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咀嚼・嚥下機能に対する診断支援システムの構

2007.12

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2010.12

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葭原明弘,インターネットを用いた遠隔診断システムの開発

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全身的骨代謝異常を反映する顎骨特異的指標の解明と，廃用症候群予防への応用

2006.12

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2009.12

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葭原明弘,骨代謝と口腔内指標との関連性の評価

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牛乳乳製品の摂取が歯科疾患に及ぼす影響の解明と廃用症候群予防の検討

2006.12

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2007.12

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葭原明弘,牛乳製品の摂取が歯科疾患に及ぼす影響の評価

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ミュータンスレンサ球菌の齲蝕原性に関わる遺伝子多型を利用した齲蝕リスク評価の構築

2003.12

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2006.12

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葭原明弘,不溶性グルカン産生能と遺伝子との関連性の評価

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成人のフッ素洗口の効果に関する追跡調査

2003.12

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2004.12

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葭原明弘,小児におけるフッ化物洗口実施経験の成人でのう蝕予防評価

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高齢者の術後回復に及ぼす口腔ケアの有効性

2002.12

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2005.12

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葭原明弘,術後急性期における口腔ケアの有効性

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高齢者の歯周病進行に対する炎症，免疫関連遺伝子多型と血中コチニン濃度の影響

2002.12

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葭原明弘,歯周病の進行と遺伝子多型との関連性の評価

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歯肉炎の保健指導に関する調査

2002.12

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葭原明弘,デンタルフロスの有効性

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歯科におけるQOL評価

2002.12

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葭原明弘,QOL評価指標の文献レビュー

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新潟市高齢者コホート調査

1998.12

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2008.12

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葭原明弘,口腔と全身との関わり

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Research Projects

がん薬物療法を受ける患者の口腔環境，口腔細菌叢とQOLの関連性の解明

Grant number：23K09455

2023.4 - 2026.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

新美奏恵, 葭原明弘, 小林正治, 隅田好美

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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口腔および口蓋扁桃マイクロバイオームが慢性腎臓病に及ぼす包括的メカニズムの解明

Grant number：22K10337

2022.4 - 2025.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

葭原明弘, 成田一衛, 杉田典子, 宮本茜, 諏訪間加奈, 新美奏恵

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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New strategies for preventing undernutrition in the elderly-tailor-made nutrition guidance method tailored to denture guidance-

Grant number：20K10290

2020.4 - 2023.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

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Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

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The role of abnormal mucosal immunity in renal senescence

Grant number：19H03674

2019.4 - 2023.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (B)

Awarding organization：Japan Society for the Promotion of Science

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Grant amount：\17030000 （ Direct Cost: \13100000 、 Indirect Cost：\3930000 ）

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歯周組織および口蓋扁桃の病態からみた慢性腎臓病に対する多角的発症メカニズムの解明

2018.4 - 2021.3

System name：科学研究費助成事業

Research category：基盤研究(B)

Awarding organization：日本学術振興会

葭原明弘

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歯周病有病状況の把握方法に関する研究事業

2018.4 - 2019.3

System name：科学研究費助成事業

Research category：受託研究（新潟県知事）

葭原明弘

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Authorship：Principal investigator Grant type：Competitive

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在宅高齢者口腔機能維持・向上研究事業

2017.4 - 2018.3

System name：科学研究費助成事業

Research category：受託研究経（新潟県知事）

葭原明弘

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Authorship：Principal investigator Grant type：Competitive

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Using step counts as a measure to predict mobility limitations in older people

Grant number：16K01825

2016.4 - 2019.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

YOSHITAKE Yutaka

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Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）

We examined step rate levels as a predictor for preventing mobility deterioration to maintain active life expectancy in older people. We recruited 600 (300 males and 300 females) physically independent, community-dwelling 70-year-old people at baseline. In a 10-year longitudinal study, the all-cause mortality and the onset of frailty considerably decreased at a level of approximately 8000 and 7300 steps per day, respectively. The current study suggests that a high daily step count is associated with a lower risk of all-cause mortality and a reduced risk for frailty in older people. In conclusion, the daily step counts (approximately 8000 steps per day) may be used as a measure of physical activity for predicting the mobility limitations in older people.

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肥満・糖尿病・歯周疾患への遺伝的背景と環境・代謝要因の相互作用に対する包括的解析

2015.4 - 2018.3

System name：科学研究費助成事業

Research category：基盤研究(B)

Awarding organization：日本学術振興会

葭原明弘

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Authorship：Principal investigator Grant type：Competitive

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Randomized controlled trial on improvement of oral function and physical function including balance function

Grant number：15K11411

2015.4 - 2018.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

MIYAZAKI HIDEO

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

The purpose of this study was to evaluate the effects of the indicators of oral and cervical functions for balance function by the physical and oral function training in elderly. As a result, tongue pressure and cervical active range of motion were associated with balance function. In addition, cervical active range of motion was improved when the physical and oral function training compared with the physical function training only. In conclusion, the oral function training for elderly was suggested the effects on improvement of the physical function.

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Development of a novel diagnosis system for periodontal disease by objective biochemical laboratory tests for salivary biomarkers.

Grant number：26293442

2014.4 - 2017.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (B)

Awarding organization：Japan Society for the Promotion of Science

ITO Hiro-O, TAMAKI Naofumi, FUKUI Makoto, YAMASHITA Yoshihisa

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Grant amount：\15860000 （ Direct Cost: \12200000 、 Indirect Cost：\3660000 ）

To take measures against periodontal disease which shows a high prevalence rate of >80% of adults, it is important to suppress gingivitis in younger generations. Diagnosis of gingivitis is currently given subjectively by dentists, and no objective diagnostic criteria; this situation prohibit proposal of specific measures against this disease. This study was conducted by collaboration of 3 independent laboratories in different universities and a health examination system by objective biochemical laboratory tests for salivary biomarkers was developed.

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脂質・糖・骨代謝異常と歯周病との共通遺伝子・修飾要因の解明および疾患モデルの構築

2012.4 - 2015.3

System name：科学研究費助成事業

Research category：基盤研究(B)

Awarding organization：日本学術振興会

葭原明弘

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Authorship：Principal investigator Grant type：Competitive

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Effects of oral exercises on physical performance in the potentially dependent elderly

Grant number：24593144

2012.4 - 2015.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

MIYAZAKI Hideo, YOSHIHARA Akihiro

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Grant amount：\5200000 （ Direct Cost: \4000000 、 Indirect Cost：\1200000 ）

Oral conditions, such as number of teeth and masticatory ability, have been associated with physical performance. On the other hand, it has been shown that oral exercises can improve oral motor functions for eating, speaking, and other mouth activities in previous researches. The aim of this study was to investigate the influence of oral exercises on physical performance among the potentially dependent elderly.
This research showed that the number of teeth influenced balance function, and this coincided with many of the earlier studies. In addition, the results may suggest that oral exercises have an effect on improvement of balance function by activation of oral motor functions among the potentially dependent elderly, so oral functional training program may help the improvement of physical performance by physical functional training. From now on, more diverse populations and complete information will be needed to clarify our findings.

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県民健康栄養調査の分析研究

2012.4 - 2013.3

System name：科学研究費助成事業

Research category：受託研究（新潟県知事）

葭原明弘

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Authorship：Principal investigator Grant type：Competitive

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条例推進重点市町村支援事業における実態調査

2012.4 - 2013.3

System name：科学研究費助成事業

Research category：受託研究（新潟県知事）

葭原明弘

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Authorship：Principal investigator Grant type：Competitive

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歯科疾患の疫学

2009.4

System name：科学研究費補助金

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Grant type：Competitive

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加齢に伴う腎機能の低下が骨代謝および歯周疾患に及ぼす影響の解明

2009.4 - 2012.3

System name：科学研究費助成事業

Research category：基盤研究(B)

Awarding organization：日本学術振興会

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Grant type：Competitive

腎臓と骨代謝には強い関連がある。加齢に伴う腎機能の低下が骨代謝および歯周疾患に及ぼす影響を解明することを目的としている。

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Construction of gingivitis preventive program based on risk assessment in schoolchildren

Grant number：19592402

2007 - 2009

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

SAKUMA Shihoko, YOSHIHARA Akihiro

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Grant amount：\3510000 （ Direct Cost: \2700000 、 Indirect Cost：\810000 ）

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Development of diagnosis support system for mastication-swallowing function

Grant number：19592231

2007 - 2009

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

SAKURAI Naoki, KOBAYSHI Hiroshi, NOMURA Shuichi, INOUE Makoto, TOYOSATO Akira, SUZUKI Ichirou, HAYASHI Takafumi, NISHIYAMA Hidemasa, SATO Naoko, SAITOU Mikiko, YOSHIHARA Akihiro, YAGI Minoru, KATOU Kazumasa, OOTAKI Youko, TAMAKI Motoko, NOMURA Akiko, TAKAGU Ritsuo, ARAI Yoshiaki

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Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

Development of diagnosis support system for mastication-swallowing function was studied by this Grant-in-Aid for Scientific Research (C) (19592231).
For developing new method of the evaluation in mastication function, we investigated or the effects of prosthetic treatment by counting the number of chewing strokes until initial swallow of rice crackers. TMD signs and symptoms of 80-year old subjects were not so common. Therefore, there is no relation between mastication function and TMD in elderly subjects.
Since a Piezoelectric Pulse Transducer (PPT) detects peripheral pulse-waves, the PPT has already been used to simply record the laryngeal upward-downward movements. Based on this fact, we developed the prototype to evaluate the swallowing function. The telemedicine in the dentistry was also tried.

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牛乳乳製品の摂取が歯科疾患に及ぼす影響の解明と廃用症候群予防の検討

2006.4 - 2007.1

System name：受託研究

Awarding organization：(社)日本酪農乳業協会

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Grant type：Competitive

Grant amount：\1500000

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全身的骨代謝異常を反映する顎骨特異的指標の解明と、廃用症候群予防への応用

2005.4 - 2009.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

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Grant type：Competitive

Grant amount：\1600000 （ Direct Cost: \1600000 ）

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Development of a caries risk assessment system using genetic polymorphisms influencing cariogenicities of mutans streptococci.

Grant number：15390649

2003 - 2005

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (B)

Awarding organization：Japan Society for the Promotion of Science

MIYAZAKI Hideo, YOSHIHARA Akihiro, HANADA Nobuhiro

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Grant amount：\5500000 （ Direct Cost: \5500000 ）

Streptococcus mutans is considered as strongly associated with dental caries. It was reported that children carrying this bacteria had significantly higher caries prevalence and development. S.mutans can colonize and accumulate on the tooth surface by glucan synthesis. GTF-I coded by gtfB gene is the most important enzyme on water-insoluble glucan (WIG) synthesis among three glucosyltransferase of S.mutans. The aim of this study was to investigate the association between genetic diversity of gtfB and WIG synthesis.
We collected paraffin-stimulated saliva from primary schoolchildren, and 21 clinical strains of S.mutans were isolated from these saliva samples. Base sequences of gtfB of these strains were determined by direct sequencing analysis.
In these days, it was revealed that GTF-I has ANDVDNSNPVVQAEQLNWL (19 aa) at 409-427 and DSIRVDAVD (9 aa) at 446-454, and these sequences are very important for enzyme activity of GTF-I. There are direct repeating units in 3'-terminal of gtfB, which are glucan binding domain. This repeating units are also important for glucan synthesis.
In this study, it was revealed that the sequence preceding the coding region of gtf B and enzymatic catalysis position (409-427 and 446-454) are highly conserved among the clinical isolates and that some strains whose WIG synthesis are low have deletion of direct repeating units in C-terminal of GTF-I.

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高齢者の術後回復に及ぼす口腔ケアの有用性に関する無作為化臨床研究

2002.4 - 2005.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

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Grant type：Competitive

Grant amount：\1600000 （ Direct Cost: \1600000 ）

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Research of a model development for tooth loss prediction

Grant number：09672097

1997 - 2000

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

ANDO Yuichi, YOSHIHARA Akihiro

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Grant amount：\2800000 （ Direct Cost: \2800000 ）

The purpose of this study was to evaluate three-year incidence of and risk factors for tooth loss in community-dwelling adults. Subjects were 269 (male 128,female 141) dentate adults in a town of Niigata Prefecture who visited both oral examination that were carried out in 1997 (baseline examination) and 2000 (follow-up examination). The follow-up rate was 37.2%. The average age at baseline was 60.6 (SD=12.8). We used multiple-logistic regression model to quantify tooth-specific and person-level risk factors for tooth loss by using variables of oral examination and questionnaire at baseline.
Three-year incidence of tooth loss was 4.9% in tooth-level, 48% in person-level. The average number of missing teeth per year was 0.33.
The results of person-level multiple logistic regression analysis showed that tooth loss was more common in persons with 10-27 present teeth, decayed teeth, oral symptom, history of dental visit within a year and habit not using interdental brush or dental floss. By using tooth-level multiple logistic regression analysis showed that incidence of tooth loss is higher in wisdom tooth, decayed tooth, crowned tooth, abutment tooth of bridge and tooth with mobility.

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Construction of Epidemiological Model for Periodontal Disease

Grant number：09470469

1997 - 2000

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (B).

Awarding organization：Japan Society for the Promotion of Science

MIYAZAKI Hideo, YOSHIHARA Akihiro

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Grant amount：\7300000 （ Direct Cost: \7300000 ）

The Purpose of this research was to identify the risk factors for periodontal disease with odds ratio. Baseline survey was carried out on 599 persons aged 70-year-old and 162 persons aged 80-year-old in Niigata City in 1997. In cross sectional study, multiple logistic regression analysis showed variables that significant correlated to sever periodontal status were age, gender, number of teeth present, filled teeth, bridge abutment teeth. In longitudinal study, variables that significant correlated to periodontal disease progression were both maximum periodontal pocket depth and attachment loss at baseline, upper and lower molars, filled teeth and abutment teeth for removable partial denture.
Gender, smoking and alcohol drinking habits were obtained using a questionnaire, while serum levels of disease markers were investigated and attachment levels were clinically recorded. For the assessment of periodontal disease progression, additional attachment loss was used if one or more sites had a 3mm or more increase in probing attachment level. Three hundred ninety four subjects(208 males and 186 females)were surveyed. Approximately 75 per cent of subjects exhibited additional attachment loss over a two-year period. Significant associations were found between additional attachment loss and smoking, and attachment level of 6mm or more at the baseline, with odds ratios of 3.75 and 2.29, respectively. Smoking habit and baseline attachment level of 6mm or more may be considered as risk factors for further attachment loss among healthy elderly people.

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フッ化物洗口法とシーラントの併用による総合的う蝕予防管理に関する研究

Grant number：04671260

1992

System name：科学研究費助成事業

Research category：一般研究(C)

Awarding organization：日本学術振興会

小林清吾, 峯田和彦, 葭原明弘

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Grant amount：\1500000 （ Direct Cost: \1500000 ）

本研究は、フッ化物洗口法を長期に渡り実施している集団に対し、シーラント処置を併用することで得られるう蝕予防のMaximum effectを明らかにするとともに、費用効果率の面からみた合理的なシーラント応用法を確立することを目的としている。フッ化物洗口法を4歳児から経験している新潟県西蒲原郡弥彦村立弥彦小学校の学童を対象とした。同校の1〜6年生におけるMean DMFTは、ベースラインである1992年春の時点で0.39と極めて低いう蝕有病状態であり、う蝕の93.7%が小窩裂溝に限局していた。春・秋年2回の学校歯科検診時に、永久歯について歯面単位の視診型検診を実施し、軽度スティッキー感のあるアブノーマルな臼歯部小窩裂溝に対して、咬合指数、咬合面歯垢指数(OPI)、歯種および学年の4指標の組み合わせにより、経過観察歯およびシーラント処置対象歯を選定し、対象歯に対してシーラント処置を行った。この際、スクリーニングされた歯牙およびシーラント処置後の状態を口腔内写真機を用い記録した。また、シーラントの保持率等を数量化し、コンピュータに入力した後解析を行った。
その結果、92年春には、アブノーマルな小窩裂溝として103歯面が検出され、スクリーニングにより57歯面がシーラント処置対象歯となった。また、92年秋には82歯面が検出されそのうち40歯面がシーラント処置対象歯となった。92年春に管理対象となった歯牙の6カ月後の経過を評価した結果、シーラント処置歯57歯面のうち、92年秋の時点で脱落が認められた歯面は7歯面(保持率:87.7%)であったが、そのうちう蝕に進行した症例は1例もなかった。また、経過観察歯となった46歯面のうちう蝕に進行したのは4歯面であった。
今後、比較対照群として、弥彦村に隣接し4歳児からフッ化物洗口法を実施している西蒲原郡岩室村の和納小学校を選定し、同校学童において、シーラント処置を行わない状態でのアブノーマルな小窩裂溝の経過を調査していく予定である。

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Teaching Experience (researchmap)

統合科目I

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社会歯科学

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統合科目Ⅰ

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予防歯科学

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口腔保健医療福祉援助学総論

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地域口腔保健推進学

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栄養学

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歯科衛生学Ⅱ

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高齢者福祉論Ⅱ

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障害者福祉論Ⅱ

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PBL入門

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歯科衛生士臨床実習Ⅰ

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歯科衛生士臨床実習Ⅱ

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社会福祉原論Ⅱ

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歯科衛生学実習Ⅰ

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健康福祉学入門

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歯科衛生学Ⅰ

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医療統計学

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歯科臨床概論

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社会調査法

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歯科衛生学実習Ⅱ

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口腔疾患の危険予測

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う蝕学

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臨床予備実習

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予防歯科学実習

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衛生学・公衆衛生学

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衛生学

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Teaching Experience

｢食べる｣

2022
Institution name：新潟大学
口腔保健福祉学研究ベーシックコース

2022
Institution name：新潟大学
歯科衛生士臨床実習III

2021
Institution name：新潟大学
児童福祉論II

2021
Institution name：新潟大学
高齢者福祉論II

2021
Institution name：新潟大学
地域口腔保健推進学IIA

2021
Institution name：新潟大学
地域口腔保健推進学IIB

2021
Institution name：新潟大学
口腔保健管理学特論

2021
Institution name：新潟大学
口腔保健福祉学研究論I

2021
Institution name：新潟大学
地域歯科保健活動

2021
Institution name：新潟大学
衛生・福祉統計学演習IIB

2021
Institution name：新潟大学
衛生・福祉統計学演習IB

2021
Institution name：新潟大学
障害者福祉論II

2021
Institution name：新潟大学
口腔保健の疫学と統計

2021
Institution name：新潟大学
摂食嚥下機能評価支援学特論

2021
Institution name：新潟大学
社会福祉原論II

2021
Institution name：新潟大学
地域口腔保健推進学IB

2021
Institution name：新潟大学
医療福祉援助学総論

2021
Institution name：新潟大学
衛生・福祉統計学演習IA

2021
Institution name：新潟大学
地域口腔保健推進学IA

2021
Institution name：新潟大学
衛生・福祉統計学演習IIA

2021
Institution name：新潟大学
口腔保健福祉学特定研究

2021

-

2023
Institution name：新潟大学
実践統計学べ－シックコース

2021

-

2023
Institution name：新潟大学
実践医学統計演習IIA

2021
Institution name：新潟大学
実践医学統計演習IA

2021
Institution name：新潟大学
歯学研究演習

2020
Institution name：新潟大学
包括社会歯科学

2020
Institution name：新潟大学
齲蝕学

2020

-

2021
Institution name：新潟大学
臨床歯学演習

2019
Institution name：新潟大学
口腔の科学

2019
Institution name：新潟大学
PBL入門

2018
Institution name：新潟大学
地域歯科保健実習

2017
Institution name：新潟大学
地域口腔保健推進学ⅡA

2017

-

2018
Institution name：新潟大学
地域口腔保健推進学ⅠA

2017

-

2018
Institution name：新潟大学
権利擁護と成年後見

2017
Institution name：新潟大学
早期臨床実習ⅡB

2017
Institution name：新潟大学
社会保障論

2017
Institution name：新潟大学
地域口腔保健推進学ⅡB

2017
Institution name：新潟大学
地域歯科保健活動

2017
Institution name：新潟大学
歯科衛生士概論

2017
Institution name：新潟大学
公的扶助論

2017
Institution name：新潟大学
保健医療制度

2017
Institution name：新潟大学
地域口腔保健推進学ⅠB

2017
Institution name：新潟大学
歯科衛生学Ⅱ

2016
Institution name：新潟大学
栄養学

2016
Institution name：新潟大学
高齢者福祉論Ⅱ

2016
Institution name：新潟大学
障害者福祉論Ⅱ

2016
Institution name：新潟大学
歯科衛生学実習Ⅰ

2015
Institution name：新潟大学
社会調査法

2015
Institution name：新潟大学
歯科衛生士臨床実習Ⅱ

2015
Institution name：新潟大学
歯科衛生学実習Ⅱ

2015
Institution name：新潟大学
歯科臨床概論

2015
Institution name：新潟大学
歯科衛生士臨床実習Ⅰ

2015
Institution name：新潟大学
社会福祉原論Ⅱ

2015

-

2016
Institution name：新潟大学
歯科衛生学Ⅰ

2013
Institution name：新潟大学
医療統計学

2013
Institution name：新潟大学
健康福祉学入門

2013
Institution name：新潟大学
口腔保健医療福祉援助学総論

2009
Institution name：新潟大学
地域口腔保健推進学

2009
Institution name：新潟大学
口腔疾患の危険予測

2009
Institution name：新潟大学
統合科目Ⅰ

2008

-

2019
Institution name：新潟大学
社会歯科学

2008

-

2018
Institution name：新潟大学
臨床予備実習

2008

-

2011
Institution name：新潟大学
衛生学

2007

-

2021
Institution name：新潟大学
予防歯科学

2007

-

2021
Institution name：新潟大学
衛生学・公衆衛生学

2007

-

2021
Institution name：新潟大学
う蝕学

2007

-

2018
Institution name：新潟大学
予防歯科学実習

2007

-

2011
Institution name：新潟大学
統合科目I

2007
Institution name：新潟大学

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