2021/10/20 更新

写真a

ヤマダ タケシ
山田 剛史
YAMADA Takeshi
所属
医歯学総合病院 小児科 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2016年3月   新潟大学 )

  • 学士(医学) ( 2001年3月   新潟大学 )

研究キーワード

  • 小児腎疾患

研究分野

  • ライフサイエンス / 胎児医学、小児成育学

  • ライフサイエンス / 腎臓内科学

経歴(researchmap)

  • 新潟大学   医歯学総合病院 小児科   助教

    2017年6月 - 現在

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  • 新潟大学   医歯学総合病院 小児科   特任助教

    2013年10月 - 2017年5月

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  • 新潟大学   医歯学総合病院 小児科   医員

    2012年4月 - 2013年9月

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  • 東京都立小児総合医療センター   腎臓内科   医員

    2010年4月 - 2012年3月

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経歴

  • 新潟大学   医歯学総合病院 小児科   助教

    2017年6月 - 現在

  • 新潟大学   医歯学総合病院 小児科   特任助教

    2013年10月 - 2017年5月

所属学協会

 

論文

  • Clinical characteristics of HNF1B-related disorders in a Japanese population. 査読

    China Nagano, Naoya Morisada, Kandai Nozu, Koichi Kamei, Ryojiro Tanaka, Shoichiro Kanda, Shinichi Shiona, Yoshinori Araki, Shinichiro Ohara, Chieko Matsumura, Katsuaki Kasahara, Yukiko Mori, Akane Seo, Kenichiro Miura, Miki Washiyama, Keisuke Sugimoto, Ryoko Harada, Satoshi Tazoe, Hiroyo Kourakata, Mayumi Enseki, Daisuke Aotani, Takeshi Yamada, Nana Sakakibara, Tomohiko Yamamura, Shogo Minamikawa, Kenji Ishikura, Shuichi Ito, Motoshi Hattori, Kazumoto Iijima

    Clinical and experimental nephrology   23 ( 9 )   1119 - 1129   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Hepatocyte nuclear factor 1β (HNF1B), located on chromosome 17q12, causes renal cysts and diabetes syndrome (RCAD). Moreover, various phenotypes related to congenital anomalies of the kidney and urinary tract (CAKUT) or Bartter-like electrolyte abnormalities can be caused by HNF1B variants. In addition, 17q12 deletion syndrome presents with multi-system disorders, as well as RCAD. As HNF1B mutations are associated with different phenotypes and genotype-phenotype relationships remain unclear, here, we extensively studied these mutations in Japan. METHODS: We performed genetic screening of RCAD, CAKUT, and Bartter-like syndrome cases. Heterozygous variants or whole-gene deletions in HNF1B were detected in 33 cases (19 and 14, respectively). All deletion cases were diagnosed as 17q12 deletion syndrome, confirmed by multiplex ligation probe amplification and/or array comparative genomic hybridization. A retrospective review of clinical data was also conducted. RESULTS: Most cases had morphological abnormalities in the renal-urinary tract system. Diabetes developed in 12 cases (38.7%). Hyperuricemia and hypomagnesemia were associated with six (19.3%) and 13 cases (41.9%), respectively. Pancreatic malformations were detected in seven cases (22.6%). Ten patients (32.3%) had liver abnormalities. Estimated glomerular filtration rates were significantly lower in the patients with heterozygous variants compared to those in patients harboring the deletion (median 37.6 vs 58.8 ml/min/1.73 m2; p = 0.0091). CONCLUSION: We present the clinical characteristics of HNF1B-related disorders. To predict renal prognosis and complications, accurate genetic diagnosis is important. Genetic testing for HNF1B mutations should be considered for patients with renal malformations, especially when associated with other organ involvement.

    DOI: 10.1007/s10157-019-01747-0

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  • Assessment of factors associated with mizoribine responsiveness in children with steroid-dependent nephrotic syndrome. 査読

    Tomomi Kondoh, Yohei Ikezumi, Katsuyuki Yokoi, Yoko Nakajima, Yuji Matsumoto, Masahiro Kaneko, Hiroya Hasegawa, Takeshi Yamada, Naonori Kumagai, Tetsuya Ito, Tetsushi Yoshikawa

    Clinical and experimental nephrology   23 ( 9 )   1154 - 1160   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Several immunosuppressants have been used to treat children with steroid-dependent nephrotic syndrome (SDNS). Mizoribine (MZR) is an immunosuppressant used to maintain remission in children with SDNS, although its effectiveness for treating SDNS remains controversial. Therefore, in this study, we assessed the clinical factors associated with children having SDNS who were successfully treated with MZR. METHODS: A total of 47 children with SDNS who underwent MZR treatment were retrospectively evaluated. Clinical features including pharmacokinetics after MZR administration were compared between MZR responders and non-responders. RESULTS: The comparison of the two groups revealed no significant differences in age, body weight (BW), daily dose of MZR per BW, serum concentration 2 h after administration (C2), peak serum concentration (Cmax), and area under the concentration curve 0-4 h after administration (AUC0-4). C2/(single dose/BW), Cmax/(single dose/BW), and AUC0-4/(single dose/BW) were significantly higher in the MZR responders than in the non-responders (all p < 0.01). Receiver operating characteristic analysis revealed that the cutoff values of C2 (single dose/kg), Cmax/(single dose/BW), and AUC0-4/(single dose/BW) were 0.55, 0.58, and 1.37, respectively. CONCLUSIONS: MZR is a useful immunosuppressant for treating frequent-relapse NS in children who are susceptible to the drug. The efficacy of MZR may be associated with not only serum concentrations defined by the dosage or absorption efficiency through MZR transporters, but also the susceptibility defined by the expression level and performance of MZR transporters on the target cells.

    DOI: 10.1007/s10157-019-01754-1

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  • Bortezomib Eliminates Plasma Cells From a Renal Graft in Plasma Cell-Rich Acute Rejection. 査読

    Tasaki M, Saito K, Nakagawa Y, Ikeda M, Imai N, Ito Y, Sudo M, Ikezumi Y, Yamada T, Hasegawa H, Kobayashi T, Miura K, Narita I, Takahashi K, Tomita Y

    Transplantation proceedings   51 ( 6 )   1732 - 1738   2019年7月

  • [LONG-TERM OUTCOME OF PEDIATRIC KIDNEY TRANSPLANTATION: A SINGLE-CENTER EXPERIENCES]. 査読

    Kuroki H, Tasaki M, Saito K, Nakagawa Y, Ikezumi Y, Suzuki T, Yamada T, Hasegawa H, Maruyama K, Imai N, Takahashi K, Tomita Y

    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology   109 ( 1 )   14 - 19   2018年

  • Haemophilus influenzae peritonitis in a girl on automated peritoneal dialysis: Case report and review of the literature. 査読 国際誌

    Taketo Otsuka, Hiroya Hasegawa, Takeshi Yamada, Utako Kaneko, Akihiko Saitoh

    IDCases   9   47 - 49   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Haemophilus influenzae is a rare cause of peritonitis in patients on peritoneal dialysis (PD). We report a case of peritonitis due to non-typeable H. influenzae in a 5-year-old girl on automated PD. The patient was successfully treated with intraperitoneal cefepime and cefazolin. The isolate was multilocus sequence type 3 and contained the hmw and hia genes but was IS1016-negative. Seven of the eight reported cases were female, indicating that sex-associated factors may be important in H. influenzae peritonitis in patients on PD. Determination of the pathogenesis of PD-associated H. influenzae peritonitis requires gene analysis and a swab sample from the vaginal introitus.

    DOI: 10.1016/j.idcr.2017.06.003

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  • Local leukocyte proliferation as a target for cyclophosphamide in the treatment of Henoch-Schönlein purpura nephritis grade VI. 査読

    Kaneko M, Ikezumi Y, Yamada T, Hasegawa H, Kaneko U, Saitoh A

    Nephrology (Carlton, Vic.)   21 ( 1 )   68 - 71   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/nep.12558

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  • Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury 査読

    Yohei Ikezumi, Toshiaki Suzuki, Takeshi Yamada, Hiroya Hasegawa, Utako Kaneko, Masanori Hara, Toshio Yanagihara, David J. Nikolic-Paterson, Akihiko Saitoh

    PEDIATRIC NEPHROLOGY   30 ( 6 )   1007 - 1017   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Prevention of chronic kidney allograft injury (CAI) is a major goal in improving kidney allograft survival; however, the mechanisms of CAI are not clearly understood. The current study investigated whether alternatively activated M2-type macrophages are involved in the development of CAI.
    A retrospective study examined kidney allograft protocol biopsies (at 1 h and at years 1, 5, and 10-a total of 41 biopsies) obtained from 13 children undergoing transplantation between 1991 and 2008 who were diagnosed with CAI: interstitial fibrosis and tubular atrophy (IF/TA) not otherwise specified (IF/TA-NOS).
    Immunostaining identified a significant increase in interstitial fibrosis with accumulation of CD68 + CD163+ M2-type macrophages. CD163+ cells were frequently localized to areas of interstitial fibrosis exhibiting collagen I deposition and accumulation of alpha-smooth muscle actin (SMA) + myofibroblasts. There was a significant correlation between interstitial CD163+ cells and the parameters of interstitial fibrosis (p &lt; 0.0001), and kidney function (r =-0.82, p &lt; 0.0001). The number of interstitial CD163+ cells at years 1 and 5 also correlated with parameters of interstitial fibrosis at years 5 and 10 respectively. Notably, urine CD163 levels correlated with interstitial CD163+ cells (r = 0.79, p &lt; 0.01) and parameters of interstitial fibrosis (p &lt; 0.0001). However, CD3+ T lymphocytic infiltration did not correlate with macrophage accumulation or fibrosis. In vitro, dexamethasone up-regulated expression of CD163 and cytokines (TGF-beta 1, FGF-2, CTGF) in human monocyte-derived macrophages, indicating a pro-fibrotic phenotype.
    Our findings identify a major population of M2-type macrophages in patients with CAI, and suggest that these M2-type macrophages might promote the development of interstitial fibrosis in IF/TA-NOS.

    DOI: 10.1007/s00467-014-3023-0

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  • Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of 2 cases with markedly increased urinary podocyte excretion 査読

    Yohei Ikezumi, Toshiaki Suzuki, Tamaki Karasawa, Utako Kaneko, Takeshi Yamada, Hiroya Hasegawa, Michio Nagata, Akihiko Saitoh

    HUMAN PATHOLOGY   45 ( 8 )   1778 - 1783   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:W B SAUNDERS CO-ELSEVIER INC  

    We report 2 cases of diffuse mesangial sclerosis (DMS) accompanied by severe podocyte excretion in urine. Patient 1 was a 9-day-old girl with a W77 mutation who developed Wilms tumor at 6 months of age and was subsequently diagnosed with Denys-Dra'sh syndrome. Patient 2 was a 1-year-old boy without a WT1 abnormality but presenting with heavy proteinuria. In both patients, histological examination showed findings of DMS. Immunohistochemical staining for synaptopodin (a podocyte marker) revealed a reduced number of podocytes in.the glomeruli with severe sclerosis; however, podocytes persisted in the relatively intact glomeruli. Some glomeruli were accompanied by sclerotic lesions surrounded by proliferating cells; immunofluorescence staining revealed a majority of these proliferating cells to be positive for claudin-1 (a parietal cell marker) but negative for synaptopodin. These findings suggest that podocyte loss and the consequent proliferation of parietal cells are common processes in the pathogenesis of DMS. (C)2014 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.humpath.2014.03.017

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  • 肉眼的血尿を契機に発見されたossifying renal tumor of infancyの男児例 査読

    山田剛史, 池住洋平, 鈴木俊明, 長谷川博也, 齋藤昭彦

    日本小児腎臓病学会雑誌   27 ( 1 )   25 - 29   2014年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人 日本小児腎臓病学会  

    DOI: 10.3165/jjpn.27.25

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  • Low Birthweight and Premature Birth Are Risk Factors for Podocytopenia and Focal Segmental Glomerulosclerosis 査読

    Yohei Ikezumi, Toshiaki Suzuki, Tamaki Karasawa, Takeshi Yamada, Hiroya Hasegawa, Hiroko Nishimura, Makoto Uchiyama

    AMERICAN JOURNAL OF NEPHROLOGY   38 ( 2 )   149 - 157   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KARGER  

    Background: Recent reports suggest that low birthweight (LBW) is a risk factor for kidney diseases, including focal segmental glomerulosclerosis (FSGS), although the underlying pathological mechanism remains unknown. Podocyte loss triggers glomerulosclerosis; however, whether FSGS in LBW children is associated with podocytopenia is unclear. Methods:We reviewed the birthweights and gestational age of all patients who underwent renal biopsies from 1995 to 2011 at our Institute. Sixteen patients had FSGS, of which 6 (37.5%) had LBW; this LBW rate was significantly higher than the overall LBW rate in Japan (9.7%). The incidence of LBW was also high in patients with minimal change nephrotic syndrome (MCNS; 12.5%). The glomerular cell numbers in biopsy sections were calculated using computer image analysis and compared with FSGS of normal birthweight (NBW-FSGS). Biopsy specimens from age-matched patients with MCNS were also compared. Wilms' tumor-1 (WT1) immunohistochemistry was performed to enumerate the podocytes. Results: All patients in the LBW-FSGS group were also preterm, with an average gestational age of 25.8 weeks. The number of podocytes per glomerulus in the LBW-FSGS patients was 34 and 24% lower as compared to that in the MCNS patients (p &lt; 0.01) and the NBW-FSGS patients (p &lt; 0.05), respectively. Similar results were observed for the WT1-positive glomerular cell number. Conclusion: LBW and premature birth were associated with FSGS development. The possibility that LBW and premature birth may be predisposing factors for severe podocytopenia in children with FSGS warrants further investigation. Copyright (C) 2013 S. Karger AG, Basel

    DOI: 10.1159/000353898

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  • Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion 査読

    Yohei Ikezumi, Toshiaki Suzuki, Tamaki Karasawa, Hiroya Hasegawa, Takeshi Yamada, Naofumi Imai, Ichiei Narita, Hiroshi Kawachi, Kevan R. Polkinghorne, David J. Nikolic-Paterson, Makoto Uchiyama

    HISTOPATHOLOGY   58 ( 2 )   198 - 210   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    Aims:
    New onset of the clinical symptoms of immunoglobulin A (IgA) nephropathy (IgAN) manifests with proliferative glomerular lesions in children, whereas adults exhibit mesangial matrix expansion and interstitial fibrosis. Alternatively, activated (M2) macrophages have been implicated in promoting tissue fibrosis in some settings. Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease.
    Methods and results:
    Biopsy specimens from paediatric (&lt; 10 years, n = 14; &gt; 12 years, n = 15) and adult (n = 27) IgAN showed a significant infiltrate of CD68+ macrophages. M2 macrophages, identified by CD163 or CD204 expression, were detected in glomeruli and the interstitium, being more prominent in adults versus young children. CD163+ and CD204+ macrophages were present in areas of fibrosis containing myofibroblasts, and double staining showed that CD163+ cells produced the profibrotic molecule, connective tissue growth factor. In young children, total CD68+ macrophages, but not M2 macrophages, correlated with glomerular hypercellularity. In contrast, in adults and older children, mesangial matrix expansion correlated with M2 macrophages but not with the total CD68+ macrophage infiltrate.
    Conclusions:
    Alternatively activated M2 macrophages are present in new-onset paediatric and adult IgAN, and this population may promote the development of fibrotic lesions.

    DOI: 10.1111/j.1365-2559.2011.03742.x

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担当経験のある授業科目

  • 疾病の成因と治療II

    2021年
    -
    現在
    機関名:新潟大学