2021/10/25 更新

写真a

シュウ レイ
周 麗
ZHOU Li
所属
研究推進機構 共用設備基盤センター 特任助教
職名
特任助教
外部リンク

学位

  • 博士(医学) ( 2006年4月   島根医科大学 )

研究キーワード

  • 小脳変性疾患

研究分野

  • ライフサイエンス / 細胞生物学

経歴(researchmap)

  • 新潟大學   研究推進機構共用設備基盤センター   特任助教

    2019年4月 - 現在

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  • 新潟大学   医歯学部神経生物解剖学分野   特任助教

    2016年4月 - 2019年3月

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  • 新潟大学   脳研究所   特任助教

    2014年4月 - 2016年3月

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  • 新潟大学脳研究所   細胞神経生物学   特別研究員

    2012年4月 - 2014年3月

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  • 新潟大学脳研究所   細胞神経生物学   ポスドク

    2009年5月 - 2012年3月

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  • 明海大学歯学部   薬理学分野MPL   研究助教

    2008年7月 - 2009年4月

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  • 北海道大学   遺伝子病制御研究所   ポスドク

    2006年4月 - 2008年3月

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▶ 全件表示

経歴

  • 新潟大学   研究推進機構 共用設備基盤センター   特任助教

    2019年4月 - 現在

  • 新潟大学   医歯学総合研究科   特任助教

    2016年4月 - 2019年3月

  • 新潟大学   脳研究所   特任助教

    2014年4月 - 2016年3月

学歴

  • 島根医科大学   医学系研究科 医学博士

    2002年4月 - 2006年4月

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    国名: 日本国

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所属学協会

 

論文

  • Decreased neurogenic proliferation;disorganized neuroblast migration;increased oligodendrogenesis in adult netrin;deficient mice 査読

    Satoru Yamagishi*, Shunsuke Ikegaya, Yurika Iga, Sumiko Mikawa, Li Zhou, Manabu Abe, Kenji Sakimura and Kohji Sato

    Front. Neurosci.   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in Dystonia musculorum mice. 査読 国際誌

    Nozomu Yoshioka, Yudai Kabata, Momona Kuriyama, Norihisa Bizen, Li Zhou, Dang M Tran, Masato Yano, Atsushi Yoshiki, Tatsuo Ushiki, Thomas J Sproule, Riichiro Abe, Hirohide Takebayashi

    Disease models & mechanisms   13 ( 5 )   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Loss-of-function mutations in dystonin (DST) can cause hereditary sensory and autonomic neuropathy type 6 (HSAN-VI) or epidermolysis bullosa simplex (EBS). Recently, DST-related diseases were recognized to be more complex than previously thought because a patient exhibited both neurological and skin manifestations, whereas others display only one or the other. A single DST locus produces at least three major DST isoforms: DST-a (neuronal isoform), DST-b (muscular isoform) and DST-e (epithelial isoform). Dystonia musculorum (dt) mice, which have mutations in Dst, were originally identified as spontaneous mutants displaying neurological phenotypes. To reveal the mechanisms underlying the phenotypic heterogeneity of DST-related diseases, we investigated two mutant strains with different mutations: a spontaneous Dst mutant (Dstdt-23Rbrc mice) and a gene-trap mutant (DstGt mice). The Dstdt-23Rbrc allele possesses a nonsense mutation in an exon shared by all Dst isoforms. The DstGt allele is predicted to inactivate Dst-a and Dst-b isoforms but not Dst-e There was a decrease in the levels of Dst-a mRNA in the neural tissue of both Dstdt-23Rbrc and DstGt homozygotes. Loss of sensory and autonomic nerve ends in the skin was observed in both Dstdt-23Rbrc and DstGt mice at postnatal stages. In contrast, Dst-e mRNA expression was reduced in the skin of Dstdt-23Rbrc mice but not in DstGt mice. Expression levels of Dst proteins in neural and cutaneous tissues correlated with Dst mRNAs. Because Dst-e encodes a structural protein in hemidesmosomes (HDs), we performed transmission electron microscopy. Lack of inner plaques and loss of keratin filament invasions underneath the HDs were observed in the basal keratinocytes of Dstdt-23Rbrc mice but not in those of DstGt mice; thus, the distinct phenotype of the skin of Dstdt-23Rbrc mice could be because of failure of Dst-e expression. These results indicate that distinct mutations within the Dst locus can cause different loss-of-function patterns among Dst isoforms, which accounts for the heterogeneous neural and skin phenotypes in dt mice and DST-related diseases.

    DOI: 10.1242/dmm.041608

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  • Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype 査読

    Zhou Li, Hossain M Ibrahim, Yamazaki Maya, Abe Manabu, Natsume Rie, Konno Kohtaro, Kageyama Shun, Komatsu Masaaki, Watanabe Masahiko, Sakimura Kenji, Takebayashi Hirohide

    Journal of Neurochemistry   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Histological detection of dynamic glial responses in the dysmyelinating Tabby-jimpy mutant brain 査読

    Masanao Ikeda, M. Ibrahim Hossain, Li Zhou, Masao Horie, Kazuhiro Ikenaka, Arata Horii, Hirohide Takebayashi

    Anatomical Science International   93 ( 1 )   119 - 127   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Tokyo  

    Oligodendrocytes (OLs) are glial cells that form myelin sheaths surrounding the axons in the central nervous system (CNS). Jimpy (jp) mutant mice are dysmyelinating disease models that show developmental abnormalities in myelinated OLs in the CNS. The causative gene in jp mice is the proteolipid protein (PLP) located on the X chromosome. Mutations in the jp allele result in exon 5 skipping and expression of abnormal PLP containing a C-terminal frame shift. Many lines of evidence suggest that abnormal PLP in OLs results in endoplasmic reticulum (ER) stress and cell death. To histologically detect glial responses in the jp mutant brain, we performed staining with lineage-specific markers. Using OL markers and OL progenitor cell marker staining, we identified reduced numbers of OL lineage cells in the jp mutant brain. Nuclear staining of the transcription factor Olig1 was observed in the Tabby-jp brain, whereas cytoplasmic Olig1 staining was observed in the wild-type brain at postnatal day 21, suggesting that active myelination was present in the mutant brain. Many microglial cells with activated morphology and intensive staining of CD11b microglia marker were observed in the internal capsule of the mutant brain, a region of white matter containing residual OLs. Activated astrocytes with high glial fibrillary acidic protein-immunoreactivity were also mainly observed in white matter. Finally, we performed in situ hybridization using C/EBP homologous protein (CHOP) antisense probes to detect ER stressed cells. CHOP mRNA was strongly expressed in residual OLs in the Tabby-jp mutant mice at postnatal stages. These data show that microglia and astrocytes exhibit dynamic glial activation in response to cell death of OLs during Tabby-jp pathogenesis, and that CHOP antisense probes may be a good marker for the detection of ER-stressed OLs in jp mutant mice.

    DOI: 10.1007/s12565-016-0383-5

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  • An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling 査読

    Yoshika Hayakawa-Yano, Satoshi Suyama, Masahiro Nogami, Masato Yugami, Ikuko Koya, Takako Furukawa, Li Zhou, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi, Atsushi Nakanishi, Hideyuki Okano, Masato Yano

    GENES & DEVELOPMENT   31 ( 18 )   1910 - 1925   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT  

    Cell type-specific transcriptomes are enabled by the action of multiple regulators, which are frequently expressed within restricted tissue regions. In the present study, we identify one such regulator, Quaking 5 (Qki5), as an RNA-binding protein (RNABP) that is expressed in early embryonic neural stem cells and subsequently down-regulated during neurogenesis. mRNA sequencing analysis in neural stem cell culture indicates that Qki proteins play supporting roles in the neural stem cell transcriptome and various forms of mRNA processing that may result from regionally restricted expression and subcellular localization. Also, our in utero electroporation gain-of-function study suggests that the nuclear-type Qki isoform Qki5 supports the neural stem cell state. We next performed in vivo transcriptome-wide protein-RNA interaction mapping to search for direct targets of Qki5 and elucidate how Qki5 regulates neural stem cell function. Combined with our transcriptome analysis, this mapping analysis yielded a bona fide map of Qki5-RNA interaction at single-nucleotide resolution, the identification of 892 Qki5 direct target genes, and an accurate Qki5-dependent alternative splicing rule in the developing brain. Last, our target gene list provides the first compelling evidence that Qki5 is associated with specific biological events; namely, cell-cell adhesion. This prediction was confirmed by histological analysis of mice in which Qki proteins were genetically ablated, which revealed disruption of the apical surface of the lateral wall in the developing brain. These data collectively indicate that Qki5 regulates communication between neural stem cells by mediating numerous RNA processing events and suggest new links between splicing regulation and neural stem cell states.

    DOI: 10.1101/gad.300822.117

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  • STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells 査読

    Li Zhou, Tomohiko Kawate, Xiaorong Liu, Young Bae Kim, Yajuan Zhao, Guohong Feng, Julian Banerji, Huw Nash, Charles Whitehurst, Satish Jindal, Arshad Siddiqui, Brian Seed, Jia L. Wolfe

    BIOORGANIC & MEDICINAL CHEMISTRY   20 ( 2 )   750 - 758   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    The STAT6 (signal transducer and activator of transcription 6) protein facilitates T-helper cell 2 (Th2) mediated responses that control IgE-mediated atopic diseases such as asthma. We have identified compounds that bind to STAT6 and inhibit STAT6 tyrosine phosphorylation induced by IL-4. In the bronchial epithelial cell line BEAS-2B, compound (R)-84 inhibits the secretion of eotaxin-3, a chemokine eliciting eosinophil infiltration. (R)-84 appears to prevent STAT6 from assuming the active dimer configuration by directly binding the protein and inhibiting tyrosine phosphorylation. (C) 2011 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bmc.2011.12.006

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  • Multiple Biological Complex of Alkaline Extract of the Leaves of Sasa senanensis Rehder 査読

    Hiroshi Sakagami, Li Zhou, Michiyo Kawano, May Maw Thet, Shoji Tanaka, Mamoru Machino, Shigeru Amano, Reina Kuroshita, Shigeru Watanabe, Qing Chu, Qin-Tao Wang, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima, Keisuke Sekine, Yoshiaki Shirataki, Chang-Hao Zhang, Yoshihiro Uesawa, Kiminori Mohri, Madoka Ketajima, Hiroshi Oizumi, Takaaki Oizumi

    IN VIVO   24 ( 5 )   735 - 743   2010年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INT INST ANTICANCER RESEARCH  

    Previous studies have shown anti-inflammatory potential of alkaline extract of the leaves of Sasa senanensis Rehder (SE). The aim of the present study was to clarity the molecular entity of SE, using various fractionation methods. SE inhibited the production of nitric oxide (NO), but not tumour necrosis factor-a by lipopolysaccharide (LPS)-stimulated mouse macrophage-like cells. Lignin carbohydrate complex prepared from SE inhibited the NO production to a comparable extent with SE, whereas chlorophyllin was more active. On successive extraction with organic solvents, nearly 90% of SE components, including chlorophyllin, were recovered from the aqueous layer. Anti-HIV activity of SE was comparable with that of lignin-carbohydrate complex, and much higher than that of chlorophyllin and n-butanol extract fractions. The CYP3A inhibitory activity of SE was significantly lower than that of grapefruit juice and chlorophyllin. Oral administration of SE slightly reduced the number of oral bacteria. When SE was applied to HPLC, nearly 70% of SE components were eluted as a single peak. These data suggest that multiple components of SE may be associated with each other in the native state or after extraction with alkaline solution.

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  • クマザサ抽出液(ササヘルス)の抗炎作用に基づく口腔環境改善効果の可能性 招待 査読

    坂上宏, 周麗, 北嶋まどか, 大泉浩史, 大泉高明

    New Food Industry   52 ( 2 )   1 - 10   2010年4月

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    記述言語:日本語   掲載種別:研究論文(その他学術会議資料等)  

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  • Possibility of improvement of oral environment by anti-inflammatory action of Sasa senanensis Rehder extract (in Japanese)

    Sakagami H, Zhou L, Kawano M, Thet MM, Hasegawa H, Tanaka S, Machino M, Amano S, Kuroshita R, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Uesawa Y, Mohri K, Chu Q, Wang QT, Kitajima M, Oizuki H, Oizumi T

    New Food Industry   52 ( 2 )   1 - 10   2010年

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  • クマザサ抽出液(ササヘルス)の抗炎作用 招待 査読

    坂上宏, 周麗, 北嶋まどか, 大泉浩史, 大泉高明

    New Food Industry   51 ( 1 )   27 - 43   2009年9月

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    記述言語:日本語   掲載種別:研究論文(研究会,シンポジウム資料等)  

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  • Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3 査読

    Dai Iwakiri, Li Zhou, Mrinal Samanta, Misako Matsumoto, Takashi Ebihara, Tsukasa Seya, Shosuke Imai, Mikiya Fujieda, Keisei Kawa, Kenzo Takada

    JOURNAL OF EXPERIMENTAL MEDICINE   206 ( 10 )   2091 - 2099   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ROCKEFELLER UNIV PRESS  

    Epstein-Barr virus-encoded small RNA (EBER) is nonpolyadenylated, noncoding RNA that forms stem-loop structure by intermolecular base-pairing, giving rise to double-stranded RNA (dsRNA)-like molecules, and exists abundantly in EBV-infected cells. Here, we report that EBER induces signaling from the Toll-like receptor 3 (TLR3), which is a sensor of viral double-stranded RNA (dsRNA) and induces type I IFN and proinflammatory cytokines. A substantial amount of EBER, which was sufficient to induce signaling from TLR3, was released from EBV-infected cells, and the majority of the released EBER existed as a complex with a cellular EBER-binding protein La, suggesting that EBER was released from the cells by active secretion of La. Sera from patients with infectious mononucleosis (IM), chronic active EBV infection (CAEBV), and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), whose general symptoms are caused by proinflammatory cytokines contained EBER, and addition of RNA purified from the sera into culture medium induced signaling from TLR3 in EBV-transformed lymphocytes and peripheral mononuclear cells. Furthermore, DCs treated with EBER showed mature phenotype and antigen presentation capacity. These findings suggest that EBER, which is released from EBV-infected cells, is responsible for immune activation by EBV, inducing type I IFN and proinflammatory cytokines. EBER-induced activation of innate immunity would account for immunopathologic diseases caused by active EBV infection.

    DOI: 10.1084/jem.20081761

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  • Inhibition of NO Production in LPS-stimulated Mouse Macrophage-like Cells by Benzo[b]cyclohept[e] [1,4]oxazine and 2-Aminotropone Derivatives 査読

    Akina Suga, Taichi Narita, Li Zhou, Hiroshi Sakagami, Kazue Satoh, Hidetsugu Wakabayashi

    IN VIVO   23 ( 5 )   691 - 697   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INT INST ANTICANCER RESEARCH  

    The aim of this study was to investigate whether a total of twenty, benzo[b]cyclohept[e][1,4]oxazines and their S-analogs, and 2-aminotropone derivatives affect the function of activated macrophages. These compounds inhibited the production of pro-inflammatory substances such as nitric oxide (NO) by lipopolysaccharide (LPS)-activated mouse macrophage-like RAW264.7 cells to different extents. Among them, benzo[b]cyclohept[e][1,4]oxazin-6(11H)-one [5] and 7-bromo-2-(4-hydroxyanilino)tropone [16] showed the highest inhibitory effects at concentrations that did not affect cellular viability, (selectivity index=74.89 and 54.15, respectively). Western blot and RT-PCR analyses showed that [16] inhibited the expression of both inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 at both protein and mRNA levels, whereas [5] inhibited only iNOS protein expression. Electron-spin resonance (ESR) spectroscopy revealed that both [5] and [16] scavenged nitric oxide (generated from NOC-7) and superoxide anion (generated by, HX-XOD reaction) only at much higher concentration. These data suggest that [16] but not [5] exerts its anti-inflammatory action against macrophages via the inhibition of iNOS and COX-2 protein expressions.

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  • Effect of Sasa senanensis Rehder Extract on NO and PGE(2) Production by Activated Mouse Macrophage-like RAW264.7 Cells 査読

    Li Zhou, Ken Hashimoto, Kazue Satoh, Yoshiko Yokote, Madoka Kitajima, Takaaki Oizumi, Hiroshi Oizumi, Hiroshi Sakagami

    IN VIVO   23 ( 5 )   773 - 777   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INT INST ANTICANCER RESEARCH  

    Alkaline extract of Sasa senanensis Rehder (SE) has shown diverse biological activity. As an extension, whether SE affects the function of activated macrophages was investigated. SE inhibited the nitric oxide (NO) production by lipopolysaccharide (LPS)-activated mouse macrophage-like RAW264.7 cells. Western blot and RT-PCR analyses demonstrated that this was due to the inhibition of inducible NO synthase (iNOS) expression at both protein and mRNA levels. ESR spectroscopy shows that SE dose-dependently scavenged the NO radical produced by NOC-7. In order to confirm the anti-inflammatory potency, possible effects on prostaglandin (PG) E-2 production and expression of enzymes involved in the arachidonic acid pathway were next investigated. It was found that SE effectively inhibited the PGE(2) production by LPS-stimulated RAW264.7 cells, although the extent of inhibition of PGE(2) was slightly less than that of NO production. SE inhibited cyclooxygenase (COX)-2 expression at both protein and mRNA levels, but to much lesser extents as compared with those for iNOS expression. SE contained much lower concentration of arginine, precursor of NO, as compared with the culture medium. These data suggest that SE exerts a weak antiinflammatory activity.

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  • Re-evaluation of anti-inflammatory activity of mastic using activated macrophages. 査読

    Zhou L, Satoh K, Takahashi K, Watanabe S, Nakamura W, Maki J, Hatano H, Takekawa F, Shimada C, Sakagami H

    In vivo   23 ( 4 )   583 - 589   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: A novel cluster of tumor-specific cytotoxins which reverse multidrug resistance 査読

    Umashankar Das, Hari N. Pati, Atulya K. Panda, Erik De Clercq, Jan Balzarini, Joseph Molnar, Zoltan Barath, Imre Ocsovszki, Masami Kawase, Li Zhou, Hiroshi Sakagami, Jonathan R. Dimmock

    BIOORGANIC & MEDICINAL CHEMISTRY   17 ( 11 )   3909 - 3915   2009年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    A series of 2-(3-aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides 3a-1 were prepared by condensation of various aryl aldehydes with 2-acetyl-3-methylquinoxaline-1,4-dioxide 2. These compounds inhibit the growth of human Molt 4/C8 and CEM T-lymphocytes and the IC(50) values are mainly in the 5-30 mu M range. The quinoxaline 1,4-dioxide 3j inhibited the growth of 58 human tumor cell lines, particularly leukemic and breast cancer neoplasms. All of the compounds 3a-1 reversed the multidrug resistance (MDR) properties of murine L-5178Y leukemic cells which were transfected with the human MDR1 gene. The MDR-reversing effect may be due to the conjugated p-electron system forming a weak electron charge transfer complex with the P-glycoprotein-mediated efflux pump. The compounds in series 2 and 3 were assessed against HL-60, HSC-2, HSC-3 and HSC-4 malignant cells as well as HGF, HPC and HPLF normal cell lines which revealed that the majority of the compounds displayed a greater toxicity to neoplastic than normal cells. Various ways in which the project may be expanded are presented. (C) 2009 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bmc.2009.04.021

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  • マスティックの機能性の追及 査読

    坂上 宏, 周麗, 佐藤和恵

    New Food Industry   51 ( 3 )   9 - 20   2009年3月

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    記述言語:日本語  

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  • Quest for the fuctionality of mastic (in Japanese)

    Sakagami H, Zhou L, Satoh K

    New Food Industry   51 ( 3 )   9 - 20   2009年

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  • Anti-inflammatory activity of Sasa senanensis Rehder extract (in Japanese)

    Sakagami H, Zhou L, Chu Q, Wang Q, Kitajima M, Oizumi H, Oizumi T, Sakagami H

    New Food Industry 51(No. 1): 27-34, 2009   51 ( 1 )   27 - 34   2009年

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  • 神経・雄性生殖系ミュータントマウス:12.疾患責任遺伝子amsの変異と異なる種類の細胞死 招待 査読

    周麗, 張傑, 荒木亜寿香, 中野晃伸, 小野栄夫, 能勢真人, 原田孝之

    日本疾患モデル学会記録   22   19 - 25   2006年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1538/expanim1992.22.19

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  • Different types of neural cell death in the cerebellum of the ataxia and male sterility (AMS) mutant mouse 査読

    L Zhou, A Araki, A Nakano, C Sezer, T Harada

    PATHOLOGY INTERNATIONAL   56 ( 4 )   173 - 180   2006年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    To investigate the mechanisms(s) of age-dependent atrophy of the cerebellum of the ataxia and male sterility (AMS) mouse at young age, the morphological changes were evaluated and the nature of neural cell death was examined. Dying Purkinje cells lacked characters of classical apoptosis except for light microscopic morphology, but their death was considered to be autonomous death triggered by the direct effect of ams mutation, because of the acute and near-complete disappearance and particular change of the cytoplasm. In contrast, in the granular layer, typical apoptotic bodies were recognized by electron microscopy, and substantial numbers of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end-labeling (TUNEL)-positive cells and activated caspase-3-positive cells were observed. Granule cell death was considered to be target-related apoptosis induced after post-synaptic Purkinje cell death, because the age-dependent changes in TUNEL-positive cell counts followed that of Purkinje cell loss and the peak value was still noted 1 week after total loss of Purkinje cells. These results indicate that both total and partial losses of Purkinje cells and granule cells, respectively, contributed to the atrophy of the AMS cerebellum. Furthermore, different types of neuronal death were recognized; the granule cell death was apoptotic while Purkinje cell death was different from that of classical apoptosis.

    DOI: 10.1111/j.144.-1827.2006.01943.x

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MISC

  • Nna1 is related to motor learning and dynamics of glutamate receptor subunits

    L. Zhou, M. Abe, M. Yamazaki, R. Natsume, K. Sakimura

    JOURNAL OF NEUROCHEMISTRY   123   127 - 127   2012年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • Anti-inflammatory activity of alkaline extract of Sasa senanensis Rehder (SE)

    Li Zhou, Ken Hashimoto, Madoka Kitajima, Hiroshi Oizumi, Takaaki Oizumi, Kazue Satoh, Hiroshi Sakagami

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   142P - 142P   2009年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Activation mechanism of macrophages by lignin fractions

    Hiroshi Sakagami, Li Zhou, Ken Hashimoto, Hideo Hasegawa, Kazue Satoh, Madoka Kitajima, Hiroshi Oizumi, Takaaki Oizumi, Yuichi Maeda, Kenji Osawa, Masaji Yamamoto, Katsuaki Utsumi

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   196P - 196P   2009年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

    Web of Science

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講演・口頭発表等

  • Nna1のカルボキシペプチダーゼドメインをコードするエクソンの欠失は、プルキンエ変性および網膜変性を引き起こす

    周麗, Hossain M Ibrahim, 阿部学, 夏目里恵, 今野幸太郎, 渡辺雅彦, 崎村建司, 竹林浩秀

    第124回日本解剖学会  2019年3月 

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    記述言語:日本語   会議種別:ポスター発表  

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  • Nna1 knockout mice deleting carboxypeptidase domain coding exons show Purkinje cell degeneration.

    Zhou Li, Abe Manabu, Yamazaki Maya, Natsume Rie, Takebayashi Hirohide, Sakimura Kenji

    第123回日本解剖学会  2018年3月 

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    記述言語:英語   会議種別:ポスター発表  

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  • Functional loss of Nna1 is responsible for Purkinje cell degeneration

    Li Zhou, Manabu Abe, Rie Natsume, Kenji Sakimura

    日本生物学会 2014  2014年11月 

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    記述言語:英語   会議種別:ポスター発表  

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  • Nna-1 is related to motor learning, anxiety-related behaviors and dynamics of glutamate receptor subunits 国際会議

    Li Zhou, Koutaro Konno, Manabu Abe, Maya Yamazaki, Rie Natsume, Masahiko Watanabe, Kenji Sakimura

    Neuroscience 2013  2013年11月 

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    記述言語:英語   会議種別:ポスター発表  

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  • Nna1 is related to motor learning and glutamate receptor dynamics

    周麗 阿部学, 山崎真弥, 夏目理恵, 崎村建司

    第55回日本神経化学会  2012年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Nna1-flox マウスの作製

    周麗 山崎真弥, 阿部学, 夏目理恵, 崎村建司

    第159回実験動物学会  2012年5月 

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    記述言語:英語   会議種別:ポスター発表  

    開催地:別府  

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  • クマザサ抽出液(笹ヘルス)の抗炎作用

    周麗 坂上宏

    第82回日本薬理学会年会  2009年3月 

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    記述言語:英語   会議種別:ポスター発表  

    開催地:横浜  

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  • 神経▪雄性生殖系ミュータントAMSマウス:12.疾患責任遺伝子ams の変異と異なる種類の細胞死.

    周麗, 張傑, 荒木亜寿香, 中野晃伸, 小野栄夫, 能勢真人, 原田孝之

    第22回日本疾患モデル学会総会 群馬  2005年10月 

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    記述言語:日本語  

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  • 神経▪雄性生殖系ミュータントAMSマウス:10.小脳神経細胞死におけるカスパーゼの動態.

    周麗, 中野晃伸, 荒木亜寿香, 原田孝之

    第94回日本病理学会総会 横浜  2005年 

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    記述言語:日本語   会議種別:ポスター発表  

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  • 神経▪雄性生殖系ミュータントAMSマウス:11.光刺激による網膜視細胞死の促進.

    周麗, 荒木亜寿香, 中野晃伸, 柳勇, 大平明弘, 原田孝之

    第46回日本組織細胞化学会総会▪学術集会  2005年 

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    記述言語:日本語  

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  • 神経▪雄性生殖系ミュータントAMS(ataxia and male sterility)マウス: 9小脳のアポトーシス細胞死の検討

    周麗, 中野晃伸, 飯島正明, 原田孝之

    第93回日本病理学会総会 札幌  2004年 

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    記述言語:日本語   会議種別:ポスター発表  

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  • Apoptosis in the cerebellum of the Ataxia and Male Sterility Mutant Mouse. 国際会議

    Zhou Li, Harada Takayuki, Araki Asuka, Sezer Cem, Iijima Masaaki, Nakano Akinobu

    7th China Japan Joint Seminar on Histochemistry and Cytochemistry(CJJSHC) WuHan (China)  2004年 

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    記述言語:英語  

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  • PPAR-γを発現する肺癌由来細胞株HPL-Tawの樹立と性状.

    周麗, 中野晃伸, Pineda Liliam, 飯島正明, Sezer Cem, 原田孝之

    第92回日本病理総会 福岡  2003年 

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    記述言語:日本語   会議種別:ポスター発表  

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▶ 全件表示

共同研究・競争的資金等の研究

  • 小脳失調症を示すpcdマウスの細胞種特異的機能解析とその治療法の探索

    研究課題/領域番号:20K07242  2020年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    周 麗

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    担当区分:研究代表者 

    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

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  • コンディションナルノック法を用いたNna1の生理機能解析

    2016年10月 - 2018年4月

    日本学術振興会  科学研究費助成事業 研究活動スタート支援  研究活動スタート支援

    周麗

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    担当区分:研究代表者  資金種別:競争的資金

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  • ヒト脳機能解明への道程としての遺伝子改変ラット作製法の開発

    研究課題/領域番号:24240048  2012年4月 - 2016年3月

    日本学術振興会  科学研究費助成事業 基盤研究(A)  基盤研究(A)

    崎村 建司, 阿部 学, 夏目 里恵, 中務 胞, 周 麗

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    配分額:46670000円 ( 直接経費:35900000円 、 間接経費:10770000円 )

    本研究の目的は、脳機能解析に利用できる遺伝子改変ラットを安価かつ容易に作製する方法を開発し、ラットを研究リソースとして利用できる基盤を作ることである。このために、ラットES細胞の培養条件、相同組換えを用いた迅速な遺伝子改変方法、確実に生殖細胞への分化をするキメラ作製法の開発おこない、遺伝子改変ラット樹立技術を確立した。
    さらにラットES細胞を用いて、マウス・ラット異種間キメラ法によりラット精子を作出するために、コンディショナル組換え法により精巣形成不全マウス作出し、高効率でラット精巣組織をマウスで作出することに成功した。本研究により、効率的に遺伝子組換えラットを作る技術が開発された。

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