Updated on 2025/06/19

写真a

 
KASEDA Ryohei
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Associate Professor
Graduate School of Medical and Dental Sciences Center of Nephrology Associate Professor
Title
Associate Professor
External link

Degree

  • 医学博士 ( 2008.3   新潟大学 )

Research Interests

  • MRI

  • HDL

  • 腎臓

Research Areas

  • Life Science / Nephrology

Research History (researchmap)

  • 新潟大学大学院医歯学総合研究科   腎・膠原病内科   講師

    2023.8

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  • Niigata University   Nephrology and Rheumatology, Medical and Dental Hospital

    2016.5 - 2023.7

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  • Niigata University   Graduate School of Medical and Dental Sciences

    2014.4 - 2016.4

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  • 米国バンダービルト大学小児科 リサーチフェローとして留学

    2011.4 - 2014.3

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  • 新潟大学大学院医歯学総合研究科 腎・膠原病内科関連病院にて勤務

    2008.4 - 2011.3

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  • 新潟大学第二内科関連病院にて勤務

    2003.4 - 2004.3

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  • 研修医として臨床研修

    2001.4 - 2003.3

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Research History

  • Niigata University   Institute of Nephrology, Graduate School of Medical and Dental Sciences   Associate Professor

    2025.4

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Associate Professor

    2025.4

  • Niigata University   Center of Nephrology, Graduate School of Medical and Dental Sciences   Lecturer

    2023.8 - 2025.3

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Lecturer

    2023.8 - 2025.3

  • Niigata University   University Medical and Dental Hospital Nephrology and Rheumatology   Assistant Professor

    2016.5 - 2023.7

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2014.4 - 2016.4

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Education

  • Niigata University   Graduate School of Medical and Dental Sciences

    2004.4 - 2008.3

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  • Niigata University   Faculty of Medicine   School of Medicine

    1995.4 - 2001.3

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Professional Memberships

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Studying abroad experiences

  • Vanderbilt University Pediatric Nephrology   Research fellow

    2011.4 - 2014.3

 

Papers

  • Genetic and protein structure prediction analyses identify a rare pathogenic PKD1 variant causing autosomal dominant polycystic kidney disease.

    Takamitsu Shiiya, Hirofumi Watanabe, Ryo Aida, Tadashi Otsuka, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ichiei Narita

    CEN case reports   2025.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic kidney disorders. The diagnosis of ADPKD requires imaging findings showing multiple kidney cysts or genetic testing, in cases where a family history is unknown. We report a patient diagnosed with ADPKD based on the identification of a rare PKD1 variant. The patient was a 41-year-old female in whom cysts and calcification in the kidneys were incidentally detected. Whole-exome sequencing identified a rare PKD1 variant (NM_001009944.3: c.11557G > A/p.E3853K). Protein structure prediction of the PKD1-PKD2 complex showed that the variant may be pathogenic, leading to the diagnosis of autosomal dominant polycystic kidney disease. A detailed family history revealed that her relatives also had ADPKD, further supporting the diagnosis of ADPKD. Comprehensive genetic analysis and protein structure prediction led to the diagnosis of ADPKD and the identification of rare causative genes. These methods are useful for diagnosing hereditary kidney diseases of unknown etiologies.

    DOI： 10.1007/s13730-025-00985-4

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  • Nephrotic syndrome induces the upregulation of cell proliferation-related genes in tubular cells in mice

    Yuya Suzuki, Ryohei Kaseda, Yusuke Nakagawa, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Taiji Matsusaka, Ichiei Narita

    Clinical and Experimental Nephrology   2024.12

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    Massive proteinuria, dyslipidemia, and hypoalbuminemia induced by nephrotic syndrome (NS) secondarily affect tubular cells. We conducted an RNA sequencing (RNA-seq) analysis using a mouse model of focal segmental glomerulosclerosis to clarify the impact of NS on tubular cells.

    Methods

    We used transgenic mice expressing hCD25 in podocytes (Nep25) to induce NS by injecting human CD25-specific immunotoxin (LMB2) at a dose of 0.625 ng/g body weight. Seven days after LMB2 injection, we extracted RNA from the whole kidney and conducted an RNA-seq analysis. Subsequently, we conducted multiple immunostaining and in situ hybridization (ISH) of differentially expressed genes (DEGs) to identify their locations and associated cell types. We also investigated the expression levels of DEGs in an additional mouse model of NS induced by adriamycin.

    Results

    After NS induction, 562 upregulated and 430 downregulated DEGs were identified using RNA-seq. An enrichment analysis revealed the upregulation of cell proliferation-related genes. We observed significant upregulation of Foxm1, a transcription factor linked to cell proliferation. Immunostaining and ISH showed that various tubular cells expressed Mki67 and Foxm1 during NS development. The adriamycin-induced NS model also demonstrated the upregulation of Mki67 and Foxm1 in tubular cells.

    Conclusions

    NS induced the upregulation of cell proliferation-related genes in tubular cells without detectable renal dysfunction. Our findings may contribute to understanding the pathological effects of nephrotic syndrome on tubular cells.

    DOI： 10.1007/s10157-024-02608-1

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    Other Link： https://link.springer.com/article/10.1007/s10157-024-02608-1/fulltext.html

  • Adolescents and parents’ knowledge of chronic kidney disease: the potential of school-based education

    Junko Nakamura, Ryohei Kaseda, Mizuki Takeuchi, Kou Kitabayashi, Ichiei Narita

    Clinical and Experimental Nephrology   2024.10

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    Preventing the progression of chronic kidney disease (CKD), reducing the incidence of new dialysis patients, and increasing public awareness about CKD are pivotal in mitigating renal impairment. This study aimed to assess the relevance of kidney disease and CKD knowledge among junior high school students and their parents.

    Methods

    A questionnaire survey on kidney function and CKD was conducted among students aged 14–15 years and their parents (851 pairs). Parents were also asked about their age, sex, and participation in health checkups.

    Results

    The study achieved a collection rate of 49.1%, with a valid response rate of 79.7%. Both junior high school students and their parents exhibited limited knowledge about kidney functions, primarily understanding these functions only in terms of waste product excretion and lacking awareness of other functions. A significant positive correlation was observed in awareness of kidney functions between students and their parents. Regarding CKD awareness, only 2.4% of students and 16.5% of parents were knowledgeable about CKD itself, while 18.9% of students and 45.3% of parents were aware of its name only. Importantly, CKD knowledge among both students and parents was associated, with those aware of CKD also demonstrating better understanding of kidney functions.

    Conclusion

    This study highlights inadequate knowledge among junior high school students and their parents regarding renal function and CKD. A significant correlation was observed in CKD awareness between students and their parents. These findings underscore the need for targeted strategies to enhance public education and awareness about kidney health.

    DOI： 10.1007/s10157-024-02574-8

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    Other Link： https://link.springer.com/article/10.1007/s10157-024-02574-8/fulltext.html

  • Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia.

    Takeru Ogino, Hirofumi Watanabe, Shoko Yamazaki, Megumi Kurosawa, Akiko Kobayashi, Naofumi Imai, Takahiro Taguchi, Hajime Umezu, Ryo Aida, Kazuki Watanabe, Tadashi Otsuka, Hideyuki Kabasawa, Ryohei Kaseda, Suguru Yamamoto, Kosuke Yoshihara, Shin Goto, Ichiei Narita

    Internal medicine (Tokyo, Japan)   2024.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, PTH and PTHrP levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression of the PTH gene and protein within the tumor, indicating ectopic PTH production. In diagnosing and treating cancers, it is necessary to consider not only PTHrP production but also ectopic PTH production.

    DOI： 10.2169/internalmedicine.3899-24

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  • 網羅的遺伝子解析と蛋白構造予測で病原PKD1バリアントを同定し常染色体顕性(優性)多発性嚢胞腎と診断した一例

    椎谷 貴光, 渡辺 博文, 相田 涼, 大塚 忠司, 忰田 亮平, 山本 卓, 金子 佳賢, 後藤 眞

    日本腎臓学会誌   66 ( 6-E )   899 - 899   2024.9

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    Language：Japanese   Publisher：(一社)日本腎臓学会  

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  • Individual dipeptidyl peptidase-4 inhibitors and acute kidney injury in patients with type 2 diabetes: A systematic review and network meta-analysis. International journal

    Satoru Mitsuboshi, Makoto Morizumi, Kazumasa Kotake, Ryohei Kaseda, Ichiei Narita

    Basic & clinical pharmacology & toxicology   135 ( 1 )   71 - 80   2024.7

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    This network meta-analysis of randomized controlled trials aimed to determine whether any individual dipeptidyl peptidase-4 (DPP-4) inhibitors increase the risk of acute kidney injury (AKI). The Medical Literature Analysis and Retrieval System Online via PubMed, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov were systematically searched to identify relevant studies. The primary outcome was AKI. A frequentist network meta-analysis was performed using a random-effects model to account for heterogeneity. Twenty-nine studies involving 56 117 participants were included. There were 918 cases of AKI (1.63%). The risk of bias was generally considered to be low. The only DPP-4 inhibitor that significantly increased the frequency of AKI when compared with placebo was sitagliptin (risk ratio 1.65, 95% confidence interval 1.22-2.23). However, because one study showed significant outliers in the funnel plot, in a highly heterogeneous population composed solely of patients undergoing surgery for coronary artery bypass graft, we conducted a post-hoc sensitivity analysis to exclude this study. The results showed no statistically significant difference in the risk of AKI between sitagliptin and placebo. Individual DPP-4 inhibitors do not appear to increase the risk of AKI. However, sitagliptin may be associated with AKI in patients with underlying severe cardiovascular disease.

    DOI： 10.1111/bcpt.14014

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  • 日本腎生検レジストリー/日本腎臓病総合レジストリー 腎硬化症における輸入細動脈肥厚と臨床所見・降圧薬の関連に関する研究

    渡辺 博文, 忰田 亮平, 後藤 眞, 成田 一衛

    日本腎臓学会誌   66 ( 4 )   525 - 525   2024.6

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    Language：Japanese   Publisher：(一社)日本腎臓学会  

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  • Megalin-related mechanism of hemolysis-induced acute kidney injury and the therapeutic strategy. International journal

    Sawako Goto, Michihiro Hosojima, Hideyuki Kabasawa, Kaho Arai, Kazuya Takemoto, Hiroyuki Aoki, Koichi Komochi, Ryota Kobayashi, Nanako Sugita, Taeko Endo, Ryohei Kaseda, Yutaka Yoshida, Ichiei Narita, Yoshiaki Hirayama, Akihiko Saito

    The Journal of pathology   2024.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Hemolysis-induced acute kidney injury (AKI) is attributed to heme-mediated proximal tubule epithelial cell (PTEC) injury and tubular cast formation due to intratubular protein condensation. Megalin is a multiligand endocytic receptor for proteins, peptides, and drugs in PTECs and mediates the uptake of free hemoglobin and the heme-scavenging protein α1-microglobulin. However, understanding of how megalin is involved in the development of hemolysis-induced AKI remains elusive. Here, we investigated the megalin-related pathogenesis of hemolysis-induced AKI and a therapeutic strategy using cilastatin, a megalin blocker. A phenylhydrazine-induced hemolysis model developed in kidney-specific mosaic megalin knockout (MegKO) mice confirmed megalin-dependent PTEC injury revealed by the co-expression of kidney injury molecule-1 (KIM-1). In the hemolysis model in kidney-specific conditional MegKO mice, the uptake of hemoglobin and α1-microglobulin as well as KIM-1 expression in PTECs was suppressed, but tubular cast formation was augmented, likely due to the nonselective inhibition of protein reabsorption in PTECs. Quartz crystal microbalance analysis revealed that cilastatin suppressed the binding of megalin with hemoglobin and α1-microglobulin. Cilastatin also inhibited the specific uptake of fluorescent hemoglobin by megalin-expressing rat yolk sac tumor-derived L2 cells. In a mouse model of hemolysis-induced AKI, repeated cilastatin administration suppressed PTEC injury by inhibiting the uptake of hemoglobin and α1-microglobulin and also prevented cast formation. Hemopexin, another heme-scavenging protein, was also found to be a novel ligand of megalin, and its binding to megalin and uptake by PTECs in the hemolysis model were suppressed by cilastatin. Mass spectrometry-based semiquantitative analysis of urinary proteins in cilastatin-treated C57BL/6J mice indicated that cilastatin suppressed the reabsorption of a limited number of megalin ligands in PTECs, including α1-microglobulin and hemopexin. Collectively, cilastatin-mediated selective megalin blockade is an effective therapeutic strategy to prevent both heme-mediated PTEC injury and cast formation in hemolysis-induced AKI. © 2024 The Pathological Society of Great Britain and Ireland.

    DOI： 10.1002/path.6284

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  • Urate-Lowering Drugs and Muscle Injury: A Systematic Review and Network Meta-Analysis. International journal

    Satoru Mitsuboshi, Makoto Morizumi, Kazumasa Kotake, Ryohei Kaseda, Ichiei Narita

    Journal of clinical pharmacology   64 ( 3 )   288 - 299   2024.3

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    Several urate-lowering drugs have been linked to muscle injury. This study investigated the association of oral urate-lowering drugs with the risk of muscle injury by performing a network meta-analysis of randomized and non-randomized controlled trials. A systematic search of MEDLINE, via PubMed, the ClinicalTrials.gov website, and the Cochrane Central Register of Controlled Trials was conducted to identify relevant studies with a primary outcome of "all muscle injuries." A random-effects model was used to perform a frequentist network meta-analysis to estimate whether there was significant heterogeneity among the studies. In total, 32 studies including 28,327 participants with 2694 (9.5%) "all muscle injuries" were assessed, and the overall risk of bias was judged to be low to moderate. No statistically significant differences were found between placebo and 6 urate-lowering therapies: allopurinol (risk ratio, RR, 1.05; 95% confidence interval, 95%CI, 0.63-1.73), febuxostat (RR 1.10, 95%CI 0.71-1.70), lesinurad (RR 7.00, 95%CI 0.31-160.36), lesinurad concomitant with allopurinol (RR 0.85, 95%CI 0.34-2.11), lesinurad concomitant with febuxostat (RR 1.97, 95%CI 0.55-7.03), and topiroxostat (RR 0.99, 95%CI 0.37-2.65). The findings suggest that there is little need to consider the risk of muscle injury when using urate-lowering drugs in the clinical setting.

    DOI： 10.1002/jcph.2369

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  • Megalin is involved in angiotensinogen-induced, angiotensin II-mediated ERK1/2 signaling to activate Na+-H+ exchanger 3 in proximal tubules. Reviewed International journal

    Sawako Goto, Yutaka Yoshida, Michihiro Hosojima, Shoji Kuwahara, Hideyuki Kabasawa, Hiroyuki Aoki, Tomomichi Iida, Ryuhei Sawada, Daisuke Ugamura, Yuta Yoshizawa, Kazuya Takemoto, Koichi Komochi, Ryota Kobayashi, Ryohei Kaseda, Eishin Yaoita, Satoru Nagatoishi, Ichiei Narita, Kouhei Tsumoto, Akihiko Saito

    Journal of hypertension   2023.9

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    BACKGROUND: Kidney angiotensin (Ang) II is produced mainly from liver-derived, glomerular-filtered angiotensinogen (AGT). Podocyte injury has been reported to increase the kidney Ang II content and induce Na+ retention depending on the function of megalin, a proximal tubular endocytosis receptor. However, how megalin regulates the renal content and action of Ang II remains elusive. METHODS: We used a mass spectrometry-based, parallel reaction-monitoring assay to quantitate Ang II in plasma, urine, and kidney homogenate of kidney-specific conditional megalin knockout (MegKO) and control (Ctl) mice. We also evaluated the pathophysiological changes in both mouse genotypes under the basal condition and under the condition of increased glomerular filtration of AGT induced by administration of recombinant mouse AGT (rec-mAGT). RESULTS: Under the basal condition, plasma and kidney Ang II levels were comparable in the two mouse groups. Ang II was detected abundantly in fresh spot urine in conditional MegKO mice. Megalin was also found to mediate the uptake of intravenously administered fluorescent Ang II by PTECs. Administration of rec-mAGT increased kidney Ang II, exerted renal extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, activated proximal tubular Na+-H+ exchanger 3 (NHE3), and decreased urinary Na+ excretion in Ctl mice, whereas these changes were suppressed but urinary Ang II was increased in conditional MegKO mice. CONCLUSION: Increased glomerular filtration of AGT is likely to augment Ang II production in the proximal tubular lumen. Thus, megalin-dependent Ang II uptake should be involved in the ERK1/2 signaling that activates proximal tubular NHE3 in vivo, thereby causing Na+ retention.

    DOI： 10.1097/HJH.0000000000003555

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  • 2型糖尿病を合併したネフローゼ症候群に対し,LDLアフェレシスが奏功した一例

    逸見 太郎, 渡辺 博文, 大塚 忠司, 忰田 亮平, 山本 卓, 後藤 眞, 成田 一衛

    日本腎臓学会誌   65 ( 6-E )   589 - 589   2023.9

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  • 2型糖尿病を合併したネフローゼ症候群に対し,LDLアフェレシスが奏功した一例

    逸見 太郎, 渡辺 博文, 大塚 忠司, 忰田 亮平, 山本 卓, 後藤 眞, 成田 一衛

    日本腎臓学会誌   65 ( 6-E )   589 - 589   2023.9

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  • 血中濃度測定で治療効果が証明された,血液透析により急性カフェイン中毒を救命し得た一例

    渡辺 博文, 大塚 忠司, 忰田 亮平, 山本 卓, 後藤 眞, 成田 一衛

    日本透析医学会雑誌   56 ( Suppl.1 )   424 - 424   2023.5

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  • 血中濃度測定で治療効果が証明された,血液透析により急性カフェイン中毒を救命し得た一例

    渡辺 博文, 大塚 忠司, 忰田 亮平, 山本 卓, 後藤 眞, 成田 一衛

    日本透析医学会雑誌   56 ( Suppl.1 )   424 - 424   2023.5

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  • メガリンが関与する造影剤腎症の発症メカニズムの解明とその予防法の開発

    後藤 佐和子, 細島 康宏, 蒲澤 秀門, 忰田 亮平, 成田 一衛, 斎藤 亮彦

    日本腎臓学会誌   65 ( 3 )   248 - 248   2023.5

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  • Sodium magnetic resonance imaging shows impairment of the counter-current multiplication system in diabetic mice kidney. International journal

    Yusuke Nakagawa, Ryohei Kaseda, Yuya Suzuki, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Yasuhiko Terada, Tomoyuki Haishi, Susumu Sasaki, Ichiei Narita

    Kidney360   4 ( 5 )   582 - 590   2023.3

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    Sodium magnetic resonance imaging can non-invasively assess sodium distribution, specifically sodium concentration in the countercurrent multiplication system in the kidney, which forms a sodium concentration gradient from the cortex to the medulla, enabling efficient water reabsorption. This study aimed to investigate whether sodium magnetic resonance imaging can detect changes in sodium concentrations under normal conditions in mice and in disease models such as a mouse model with diabetes mellitus. Methods: We performed sodium and proton nuclear magnetic resonance imaging using a 9.4-T vertical standard-bore super-conducting magnet. Results: A condition of deep anesthesia, with widened breath intervals, or furosemide administration in 6-week-old C57BL/6JJcl mice showed a decrease in both tissue sodium concentrations in the medulla and sodium concentration gradients from the cortex to the medulla. Further, sodium magnetic resonance imaging revealed reductions in the sodium concentration of the medulla and in the gradient from the cortex to the medulla in BKS.Cg-Leprdb+/+ Leprdb/Jcl mice at very early type-2 diabetes mellitus stages compared to corresponding control BKS.Cg-m+/m+/Jcl mice. Conclusions: The kidneys of BKS.Cg-Leprdb+/+ Leprdb/Jcl mice aged 6 weeks showed impairments in the countercurrent multiplication system. We propose the utility of 23Na MRI for evaluating functional changes in diabetic kidney disease, not as markers that reflect structural damage. Thus, 23Na MRI may be a potential very early marker for structures beyond the glomerulus; this may prompt intervention with novel efficacious tubule-targeting therapies.

    DOI： 10.34067/KID.0000000000000072

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  • Assessing fluid volume and determining outcomes of acute heart failure using plasma human atrial natriuretic peptide.

    Yuya Suzuki, Tadashi Otsuka, Yuki Yoshioka, Tomomichi Iida, Shingo Maruyama, Hirofumi Watanabe, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ryuji Aoyagi, Ichiei Narita

    Clinical and experimental nephrology   27 ( 6 )   565 - 573   2023.3

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    BACKGROUND: The post-dialysis plasma level of human atrial natriuretic peptide (hANP) reflects the fluid volume in patients on hemodialysis. The threshold hANP level is reportedly 100 pg/mL; however, the clinical usefulness of the threshold hANP level for volume control has not been sufficiently studied. METHODS: We conducted a single-center, retrospective, observational study that included 156 hemodialysis patients without atrial fibrillation. First, we examined the usefulness of the threshold hANP level (100 pg/mL) for predicting hypoxemia due to congestion in a short-term observational study from December 30, 2015 to January 5, 2016. Subsequently, we conducted a 5-year follow-up study wherein the outcomes were hospitalization due to acute heart failure (AHF), development of cardiovascular diseases (CVD), and all-cause death. Finally, we collected echocardiography data to investigate the relationship between cardiac function and hANP. RESULTS: Our short-term observational study showed that patients with an hANP level ≥ 100 pg/mL developed hypoxemia due to congestion (odds ratio, 3.52; 95% confidence interval, 1.06-11.71; P = 0.040). At the 5-year follow-up, patients with an hANP level ≥ 100 pg/mL had significantly higher rates of hospitalization due to AHF, CVD, and all-cause death based on the log-rank test (P = 0.003, P = 0.019, P < 0.001, respectively). Cardiac disfunctions were significantly associated with the high hANP level. CONCLUSIONS: The hANP level is indicative of both fluid volume and cardiac dysfunction. A threshold hANP level of 100 pg/mL can serve as a predictive marker for AHF and a practical indicator for volume control.

    DOI： 10.1007/s10157-023-02333-1

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  • Efficacy of Low-Protein Rice for Dietary Protein Restriction in CKD Patients: A Multicenter, Randomized, Controlled Study. International journal

    Michihiro Hosojima, Hideyuki Kabasawa, Ryohei Kaseda, Tomomi Ishikawa-Tanaka, Yoshitsugu Obi, Toshiko Murayama, Shoji Kuwahara, Yoshiki Suzuki, Ichiei Narita, Akihiko Saito

    Kidney360   3 ( 11 )   1861 - 1870   2022.11

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    BACKGROUND: The benefits of dietary protein restriction in CKD remain unclear, largely due to inadequate adherence in most clinical trials. We examined whether low-protein rice (LPR) previously developed to reduce the protein content of rice, a major staple food, would help improve adherence to dietary protein restriction. METHODS: This open-label, multicenter, randomized, controlled trial evaluated the efficacy of LPR use for reducing dietary protein intake (DPI) in patients with CKD stages G3aA2-G4. Participants were randomly assigned in a 1:1 ratio to an LPR or control group and were followed up for 24 weeks. Both groups received regular counseling by dietitians to help achieve a target DPI of 0.7 g/kg ideal body weight (IBW) per day. The amount of protein in LPR is about 4% of that in ordinary rice, and the participants in the LPR group were instructed to consume LPR with at least two meals per day. The primary outcome was estimated dietary protein intake (eDPI) determined using the Maroni formula. The secondary outcomes included creatinine clearance (CCr) and urinary protein on the basis of 24-hour urine collection. RESULTS: In total, 51 patients were randomized to either the LPR group or the control group. At baseline, mean age was 62.5 years, 70% were men, mean CCr was 52.0 ml/min, and mean eDPI was 0.99 g/kg IBW per day. At 24 weeks, mean eDPI decreased to 0.80 g/kg IBW per day in the LPR group and to 0.91 g/kg IBW per day in the control group, giving a between-group difference of 0.11 g/kg IBW per day (95% confidence interval, 0.03 to 0.19 g/kg IBW per day; P=0.006). There was no significant between-group difference in CCr, but urinary protein was lower at 24 weeks in the LPR group than in the control group. CONCLUSIONS: LPR is a feasible tool for efficiently reducing DPI in patients with CKD. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Randomized, Multicenter, Controlled Study for the Efficacy of Low-Protein Rice Diet in Patients with Chronic Kidney Disease, UMIN000015630.

    DOI： 10.34067/KID.0002982022

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  • IgA腎症を合併したANCA関連腎炎の一例

    山崎 翔子, 相田 涼, 山口 浩毅, 渡辺 博文, 大塚 忠司, 蒲澤 秀門, 忰田 亮平, 伊藤 由美, 後藤 眞, 成田 一衛

    日本腎臓学会誌   64 ( 6-E )   544 - 544   2022.10

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  • Urinary A- and C-megalin predict progression of diabetic kidney disease: an exploratory retrospective cohort study. International journal

    Tomomichi Iida, Michihiro Hosojima, Hideyuki Kabasawa, Keiko Yamamoto-Kabasawa, Sawako Goto, Takahiro Tanaka, Nobutaka Kitamura, Mitsutaka Nakada, Shino Itoh, Shinya Ogasawara, Ryohei Kaseda, Yoshiki Suzuki, Ichiei Narita, Akihiko Saito

    Journal of diabetes and its complications   36 ( 11 )   108312 - 108312   2022.9

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    AIMS: Megalin, a proximal tubular endocytosis receptor, is excreted in urine in two forms: ectodomain (A-megalin) and full-length (C-megalin). We explored whether urinary megalin levels can be used as independent prognostic biomarkers in the progression of diabetic kidney disease (DKD). METHODS: The associations between baseline urinary A-megalin/creatinine (Cr) and/or C-megalin/Cr levels and the subsequent estimated glomerular filtration rate (eGFR) slope were analyzed using a generalized estimating equation. Patients were categorized into higher or lower groups based on the optimal cutoff values, obtained from a receiver operating characteristic curve, of the two forms of urinary megalin. RESULTS: We retrospectively analyzed 188 patients with type 2 diabetes. The eGFR slopes of the higher A-megalin/Cr and higher C-megalin/Cr groups were - 0.904 and -0.749 ml/min/1.73 m2/year steeper than those of the lower groups, respectively. Moreover, the eGFR slope was -1.888 ml/min/1.73 m2/year steeper in the group with both higher A- and higher C-megalin/Cr than in the other group. These results remained significant when adjusted for known urinary biomarkers (albumin, α1-microglobulin, β2-microglobulin, and N-acetyl-β-d-glucosaminidase). CONCLUSIONS: Urinary A- and C-megalin/Cr levels are likely to be prognostic biomarkers in the progression of DKD independent of other urinary biomarkers.

    DOI： 10.1016/j.jdiacomp.2022.108312

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  • 処方元医療機関とCKDステージにおける過量投与疑いのある薬剤の調査

    早川 兼司, 三星 知, 須藤 晴美, 忰田 亮平, 成田 一衛

    日本腎臓病薬物療法学会誌   11 ( 2 )   173 - 177   2022.8

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  • Association between Anti-Osteoporotic Drugs and Risk of Acute Kidney Injury: A Cross-Sectional Study Using Disproportional Analysis and a Pharmacovigilance Database. International journal

    Satoru Mitsuboshi, Ryohei Kaseda, Ichiei Narita

    Journal of clinical pharmacology   62 ( 11 )   1419 - 1425   2022.6

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    The number of fractures related to osteoporosis is expected to increase. Therefore, clarifying the risk of acute kidney injury (AKI) associated with each type of anti-osteoporotic drug may avoid discontinuation of osteoporosis pharmacotherapy due to onset of AKI. This cross-sectional study using disproportional analysis and a pharmacovigilance database assessed the risk of AKI with various anti-osteoporotic drugs by analyzing data entered into the US Food and Drug Administration's Adverse Event Reporting System (FAERS) from April 2014 to March 2021 and the Medical Data Vision (MDV) database in Japan in November 2021. All anti-osteoporotic drugs were investigated, including bisphosphonates, selective estrogen receptor modulators, denosumab, romosozumab, abaloparatide, and teriparatide. In the analysis of FAERS data, disproportionality for decreasing AKI was observed for oral ibandronate [reporting odds ratios (ROR) 0.22, 95% confidence interval (CI) 0.09-0.45, P < 0.01], bazedoxifene (ROR 0.26, 95% CI 0.05-0.77, P = 0.01), and intravenous ibandronate (ROR 0.39, 95% CI 0.14-0.86, P = 0.01). In the analysis of the MDV data, the incidence of AKI was lower in patients taking intravenous ibandronate [odds ratio (OR) 0.22, 95% CI 0.06-0.89, P = 0.03], and the incidence of AKI was higher in patients taking oral alendronate (OR 2.40, 95% CI 2.08-2.77, P < 0.01). Risk of AKI may differ even among oral anti-osteoporotic drugs, and the evidence of this association should be assessed further in future drug safety studies. This article is protected by copyright. All rights reserved.

    DOI： 10.1002/jcph.2091

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  • Association Between the Use of Sodium-Glucose Cotransporter-2 Inhibitors and Drug-Induced Acute Kidney Injury: Analysis of 2 Databases. International journal

    Mitsuboshi Satoru, Ryohei Kaseda, Ichiei Narita

    Journal of clinical pharmacology   62 ( 5 )   631 - 635   2022.5

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    The association between the use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors and the occurrence of drug-induced kidney injury has not been evaluated. This study assessed whether the use of SGLT-2 inhibitors decreases the risk of drug-induced acute kidney injury (AKI) using the US Food and Drug Administration's Adverse Event Reporting System and the Medical Data Vision database. The occurrence of AKI in SGLT-2 inhibitor users and dipeptidyl peptidase-4 (DPP-4) inhibitor users was compared using both databases. In the US Food and Drug Administration's Adverse Event Reporting System analysis, disproportionality for AKI was observed between DPP-4 inhibitor users and SGLT-2 inhibitor users administered nonsteroidal anti-inflammatory drugs (reporting odds ratio, 0.65; 95%CI, 0.48-0.88; P < .01) and thiazide diuretics (reporting odds ratio, 0.78; 95%CI, 0.67-0.90; P < .01). In Medical Data Vision analysis, SGLT-2 inhibitor users administered nonsteroidal anti-inflammatory drugs (odds ratio [OR], 0.46; 95%CI, 0.41-0.53; P < .01), anti-herpes simplex virus drugs (OR, 0.20; 95%CI, 0.07-0.53; P < .01), thiazide diuretics (OR, 0.50; 95%CI, 0.36-0.71, P < .01), and loop diuretics (OR, 0.71; 95%CI, 0.62-0.83; P < .01) had a lower incidence of AKI compared with DPP-4 inhibitor users receiving the same drugs. No differences were observed in the risk of AKI between SGLT-2 and DPP-4 inhibitor users administered vancomycin and cisplatin in both databases. The use of SGLT-2 inhibitors might reduce the risk of drug-induced AKI caused by some drugs.

    DOI： 10.1002/jcph.1998

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  • 2型糖尿病患者における尿中メガリン測定による腎予後予測

    飯田 倫理, 細島 康宏, 蒲澤 秀門, 蒲澤 佳子, 後藤 佐和子, 田中 崇裕, 北村 信隆, 忰田 亮平, 鈴木 芳樹, 成田 一衛, 斎藤 亮彦

    日本腎臓学会誌   64 ( 3 )   240 - 240   2022.5

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  • 2型糖尿病患者における尿中メガリンの腎予後予測能の検討

    飯田 倫理, 細島 康宏, 蒲澤 秀門, 蒲澤 佳子, 後藤 佐和子, 田中 崇裕, 北村 信隆, 忰田 亮平, 鈴木 芳樹, 成田 一衛, 斎藤 亮彦

    糖尿病   65 ( Suppl.1 )   S - 150   2022.4

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  • ミオグロビン除去目的にオンラインHDFを施行した横紋筋融解症の2例

    逸見 太郎, 大塚 忠司, 梨本 友美, 土田 雅文, 渡辺 博文, 忰田 亮平, 長谷川 進, 山本 卓, 成田 一衛

    Niigata Blood Purification Conferenceプログラム・一般演題抄録   2021   6 - 6   2022.2

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  • Development of an Add-on 23Na-MRI Radiofrequency Platform for a 1H-MRI System Using a Crossband Repeater: Proof-of-concept.

    Michiru Kajiwara, Tomoyuki Haishi, Dwi Prananto, Susumu Sasaki, Ryohei Kaseda, Ichiei Narita, Yasuhiko Terada

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   22 ( 1 )   103 - 115   2021.12

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    23Na-MRI provides information on Na+ content, and its application in the medical field has been highly anticipated. However, for existing clinical 1H-MRI systems, its implementation requires an additional broadband RF transmitter, dedicated transceivers, and RF coils for Na+ imaging. However, a standard medical MRI system cannot often be modified to perform 23Na imaging. We have developed an add-on crossband RF repeater system that enables 23Na-MRI simply by inserting it into the magnet bore of an existing 1H MRI. The three axis gradient fields controlled by the 1H-MRI system were directly used for 23Na imaging without any deformation. A crossband repeater is a common technique used for amateur radio. This concept was proven by a saline solution phantom and in vivo mouse experiments. This add-on RF platform is applicable to medical 1H MRI systems and can enhance the application of 23Na-MRI in clinical usage.

    DOI： 10.2463/mrms.tn.2021-0094

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  • 腎特異的遺伝子ACSM2の機能と臨床的有用性

    渡辺 博文, 忰田 亮平, 後藤 眞, 成田 一衛

    新潟県医師会報   ( 861 )   8 - 9   2021.12

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  • Association between steroid use and nephropathy in patients who were administered a proton pump inhibitor: Analysis of the Japanese Adverse Event Report database Reviewed

    Satoru Mitsuboshi, Ryohei Kaseda, Ichiei Narita

    The Journal of Clinical Pharmacology   2021.9

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    DOI： 10.1002/jcph.1964

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  • Rice Endosperm Protein Improves the Anti-Inflammatory Effects of High-Density Lipoprotein and Produces Lower Atherosclerotic Lesion Accelerated by the Renal Mass Reduction than Casein in a Mouse Model. Reviewed International journal

    Ryohei Kaseda, Michihiro Hosojima, Shoji Kuwahara, Hideyuki Kabasawa, Hiroyuki Aoki, Yuki Higuchi, Valentina Kon, Ichiei Narita, Akihiko Saito

    Journal of the American College of Nutrition   41 ( 7 )   1 - 11   2021.8

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    Chronic kidney disease (CKD) impairs the anti-inflammatory effects of high-density lipoprotein (HDL) and increases cardiovascular mortality. Though the potential role of dietary interventions to manage HDL is well studied, the clinical trials aimed to increase HDL levels have failed to reduce cardiovascular risk, rendering HDL function to be explored as a more relevant clinical parameter. This study investigates the effects of rice endosperm protein (REP), a plant-based protein, on the anti-inflammatory properties of HDL and renal injury-driven atherosclerosis in comparison with casein, an animal protein. Ten-week-old apolipoprotein E-deficient hyperlipidemic mice underwent uninephrectomy. The mice (n = 6 each) were pair-fed a normal casein-based diet or a REP-based diet (both with 20.0% protein content) for seven weeks. Atherosclerotic lesions were detected by en face Sudan IV staining of the aorta. The number and sizes of the atherosclerotic lesions were significantly lower in the REP-based diet-fed group than the casein-based diet-fed group (p = 0.038). However, the REP-based diet neither elicited an ameliorative effect on kidney function or histology nor impacted the cholesterol profiles. Furthermore, HDL from the REP-based diet-fed mice significantly suppressed the inflammatory cytokine response of human umbilical vein endothelial cells than that from the casein-based diet-fed mice (MCP-1, p = 0.010; IL-6, p = 0.011; IL-1β, p = 0.028). The REP-based diet has a higher potential to lessen the atherosclerotic lesions accelerated by renal mass reduction than a casein-based diet, which could be associated with the anti-inflammatory effects of HDL.

    DOI： 10.1080/07315724.2021.1950584

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  • Amantadine and Fatal Events in Patients With Chronic Kidney Disease: Analysis of the Japanese Adverse Event Report Database. Reviewed International journal

    Satoru Mitsuboshi, Ryohei Kaseda, Ichiei Narita

    The Annals of pharmacotherapy   56 ( 2 )   10600280211022439 - 10600280211022439   2021.6

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  • 23Na-MRIを用いた2型糖尿病マウスにおける腎臓内Na+濃度勾配の検討

    中川 裕介, 忰田 亮平, 拝師 智之, 佐々木 進, 成田 一衛

    日本腎臓学会誌   63 ( 4 )   507 - 507   2021.6

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  • 日本腎臓学会でのバーチャルスライド登録とその展望

    忰田 亮平, 大塚 忠司, 金子 佳賢, 杉山 斉, 清水 章, 横山 仁, 佐藤 博, 成田 一衛

    腎臓内科   13 ( 4 )   534 - 541   2021.4

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  • 【腎疾患領域における難病対策】わが国の難治性腎障害に関する調査研究班の取り組み

    成田 一衛, 忰田 亮平, 大塚 忠司, 金子 佳賢

    腎臓内科   13 ( 1 )   12 - 16   2021.1

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  • Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodialysis: A Prospective Observational Exploratory Study. Reviewed International journal

    Tomomi Ishikawa-Tanaka, Michihiro Hosojima, Hideyuki Kabasawa, Ryohei Kaseda, Ryota Yasukawa, Yusuke Yata, Shoji Kuwahara, Emiko Kono, Takuma Takata, Noriaki Iino, Takahiro Tanaka, Nobutaka Kitamura, Yoshiki Suzuki, Akihiko Saito, Ichiei Narita

    Diabetes therapy : research, treatment and education of diabetes and related disorders   11 ( 12 )   2845 - 2861   2020.12

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    INTRODUCTION: The precise blood glucose (BG) profile of hemodialysis patients is unclear, as is the effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors in hemodialysis patients with type 2 diabetes. Here, we used continuous glucose monitoring (CGM) to evaluate BG variability in these patients and to assess the efficacy of DPP-4 inhibitors, particularly during hemodialysis sessions and at nighttime (UMIN000012638). METHODS: We examined BG profiles using CGM in 31 maintenance hemodialysis patients with type 2 diabetes. Differences between patients with and without DPP-4 inhibitors (n = 15 and 16, respectively) were analyzed using a linear mixed-effects model to assess changes in glucose levels in 5-min intervals. RESULTS: The model revealed that DPP-4 inhibitor use was significantly associated with suppression of a rapid drop in glucose levels, both with and without adjustment for BG levels at the start of hemodialysis. Moreover, the model revealed that the two groups differed significantly in the pattern of changes in BG levels from 0:00 to 6:55 am. DPP-4 inhibitors suppressed the tendency for subsequent nocturnal hypoglycemia. CONCLUSIONS: This prospective observational exploratory study showed that DPP-4 inhibitors could suppress BG variability during hemodialysis sessions as well as subsequent nocturnal changes in patients with type 2 diabetes. TRIAL REGISTRATION: ClinicalTrials.gov identifier, UMIN000012638.

    DOI： 10.1007/s13300-020-00928-5

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  • インスリン使用中の維持血液透析患者におけるデュラグルチド併用による血糖管理の有効性およびQOL改善に関する探索的臨床試験

    宇賀村 大亮, 細島 康宏, 蒲澤 秀門, 田邊 直仁, 吉澤 優太, 忰田 亮平, 鈴木 芳樹, 成田 一衛, 斎藤 亮彦

    糖尿病   63 ( Suppl.1 )   S - 300   2020.8

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  • メガリンを介する腎内レニン-アンジオテンシン(Ang)系(RAS)の動的均衡化制御機構

    後藤 佐和子, 吉田 豊, 細島 康宏, 蒲澤 秀門, 忰田 亮平, 成田 一衛, 斎藤 亮彦

    日本腎臓学会誌   62 ( 4 )   370 - 370   2020.7

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  • マウス尿中メガリン測定用サンドイッチELISAの開発とその応用

    早福 莉那, 後藤 佐和子, 細島 康宏, 蒲澤 秀門, 忰田 亮平, 成田 一衛, 斎藤 亮彦

    日本腎臓学会誌   62 ( 4 )   339 - 339   2020.7

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  • 23Na-MRIを用いた腎臓の病態生理の検討

    忰田 亮平, 拝師 智之, 佐々木 進, 成田 一衛

    日本腎臓学会誌   62 ( 4 )   296 - 296   2020.7

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  • 多発性嚢胞腎・多発性肝嚢胞が経時的に増大し、慢性呼吸不全で死亡した1例

    酒巻 裕一, 忰田 亮平, 越川 智康, 吉岡 友基, 岡部 正明, 成田 一衛, 青柳 竜治

    新潟医学会雑誌   134 ( 6 )   199 - 205   2020.6

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  • SGLT2阻害薬による腎保護作用機序と尿中コンパニオン診断法の検討

    忰田 亮平, 飯田 倫理, 細島 康宏, 蒲澤 秀門, 後藤 佐和子, 桑原 頌治, 宇賀村 大亮, 吉澤 優太, 田中 崇裕, 成田 一衛, 斎藤 亮彦

    臨床薬理の進歩   ( 41 )   148 - 153   2020.6

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  • Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood. Reviewed International journal

    Yuki Higuchi, Michihiro Hosojima, Hideyuki Kabasawa, Shoji Kuwahara, Sawako Goto, Koji Toba, Ryohei Kaseda, Takahiro Tanaka, Nobutaka Kitamura, Hayato Takihara, Shujiro Okuda, Masayuki Taniguchi, Hitoshi Arao, Ichiei Narita, Akihiko Saito

    Nutrients   11 ( 12 )   2019.12

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    Obesity and related disorders, which are increasing in adults worldwide, are closely linked to childhood diet and are associated with chronic inflammation. Rice endosperm protein (REP) intake during adulthood has been reported to improve lipid metabolism and suppress the progression of diabetic kidney disease in animal models. However, the effects of REP intake during childhood on adulthood health are unclear. Therefore, we used a mouse model to experimentally investigate the preconditioning effects of REP intake during childhood on the development of obesity and related disorders in adulthood. Male C57BL/6J mice were pair-fed a normal-fat diet containing casein or REP during the juvenile period and then a high-fat diet (HFD) containing casein or REP during adulthood. Mice fed REP during the juvenile period showed better body weight, blood pressure, serum lipid profiles, lipopolysaccharide (LPS)-binding protein levels, and glucose tolerance in adulthood than those fed casein during the juvenile period. HFD-induced renal tubulo-glomerular alterations and hepatic microvesicular steatosis were less evident in REP-fed mice than in casein-fed ones. REP intake during the juvenile period improved HFD-induced dysbiosis (i.e., Escherichia genus proliferation and reduced gut microbiota diversity), thereby suppressing endotoxin-related chronic inflammation. Indeed, REP-derived peptides showed antibacterial activity against Escherichia coli, a major producer of LPS. In conclusion, REP supplementation during the juvenile period may regulate the gut microbiota and thus suppress the development of obesity and related disorders in adulthood in mice.

    DOI： 10.3390/nu11122919

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  • Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study. Reviewed International journal

    Satoshi Shoji, Michihiro Hosojima, Hideyuki Kabasawa, Rie Kondo, Satoru Miura, Satoshi Watanabe, Nobumasa Aoki, Ryohei Kaseda, Shoji Kuwahara, Naohito Tanabe, Yoshiaki Hirayama, Ichiei Narita, Toshiaki Kikuchi, Hiroshi Kagamu, Akihiko Saito

    BMC cancer   19 ( 1 )   1170 - 1170   2019.12

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    BACKGROUND: Cisplatin is a potent chemotherapeutic agent used to treat a variety of solid tumors. One of the major side effects of cisplatin is dose-limiting nephrotoxicity. We recently demonstrated that the renal uptake of cisplatin and resultant cisplatin-induced nephrotoxicity are mediated in part by megalin, an endocytic receptor in proximal tubule epithelial cells (PTECs). We also developed sandwich enzyme-linked immunosorbent assays to measure the megalin ectodomain (A-megalin) and full-length megalin (C-megalin) in urine using monoclonal antibodies against the amino- and carboxyl-termini of megalin, respectively. The present study examined the correlation of urinary megalin level with cisplatin-induced nephrotoxicity and its utility as a biomarker in patients with thoracic cancer. METHODS: This prospective observational study involved 45 chemotherapy-naïve patients scheduled to receive chemotherapy with ≥60 mg/m2 cisplatin for histologically diagnosed small cell lung cancer, non-small cell lung cancer, or malignant pleural mesothelioma. Before and after the first course of chemotherapy, we measured urinary A- and C-megalin and other markers of PTEC injury, such as N-acetyl-β-D-glucosaminidase, α1-microglobulin, β2-microglobulin, neutrophil gelatinase-associated lipocalin, and liver-type fatty acid-binding protein, and compared the values with the change in the estimated glomerular filtration rate (eGFR) and clinical risk factors for renal impairment. RESULTS: A negative correlation was found between baseline urinary A-megalin levels and change in eGFR (r = - 0.458, P = 0.002). According to Kaplan-Meier survival curves, eGFR decline was associated with the baseline urinary A-megalin quartile (P = 0.038). In addition, according to the hazard ratios (HRs) for eGFR decline > 10 mL/min/1.73 m2 calculated using a Cox proportional hazard model, the highest quartile had a significantly higher risk of eGFR decline compared with the lowest quartile (HR 7.243; 95% confidence interval 1.545-33.962). Other baseline urinary markers showed no correlation with eGFR decline. CONCLUSIONS: This is the first report demonstrating that prechemotherapy urinary A-megalin levels are correlated with the development of cisplatin-induced nephrotoxicity. This finding has clinical implications for the identification of patients at risk for cisplatin-induced nephrotoxicity and the development of possible prophylactic therapies.

    DOI： 10.1186/s12885-019-6398-2

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  • Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease. Reviewed International journal

    Koji Toba, Michihiro Hosojima, Hideyuki Kabasawa, Shoji Kuwahara, Toshiko Murayama, Keiko Yamamoto-Kabasawa, Ryohei Kaseda, Eri Wada, Reiko Watanabe, Naohito Tanabe, Yoshiki Suzuki, Ichiei Narita, Akihiko Saito

    BMC nephrology   20 ( 1 )   421 - 421   2019.11

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    BACKGROUND: Dietary acid load has been suggested to mediate the progression of chronic kidney disease (CKD). However, it is unclear what kinds of foods are actually associated with dietary acid load in patients with CKD. The self-administered diet history questionnaire (DHQ), which semi-quantitatively assesses the dietary habits of Japanese individuals through 150 question items, can estimate average daily intake of various foods and nutrients during the previous month. Using the DHQ, we investigated the association of dietary acid load with CKD progression. We also analyzed the kinds of food that significantly affect dietary acid load. METHODS: Subjects were 96 outpatients with CKD (average estimated glomerular filtration rate [eGFR], 53.0 ± 18.1 ml/min/1.73 m2) at Niigata University Hospital, who had completed the DHQ in 2011. We calculated net endogenous acid production (NEAP) from potassium and protein intake evaluated by the DHQ in order to assess dietary acid load. CKD progression was assessed by comparing eGFR between 2008 and 2014. RESULTS: NEAP was not correlated with protein intake (r = 0.088, p = 0.398), but was negatively correlated with potassium intake (r = - 0.748, p < 0.001). Reduction in eGFR from 2008 to 2014 was estimated to be significantly greater in patients with higher NEAP (NEAP > 50.1 mEq/day, n = 45) than in those with lower NEAP (NEAP ≤50.1 mEq/day, n = 50) by 5.9 (95% confidence interval [95%CI], 0.1 to 11.6) ml/min/1.73 m2. According to multiple logistic regression analysis, higher NEAP was significantly associated with lower intake of fruits (odds ratio [OR], 6.454; 95%CI, 2.19 to 19.00), green and yellow vegetables (OR, 5.18; 95%CI, 1.83 to14.66), and other vegetables (OR, 3.87; 95%CI, 1.29 to 11.62). CONCLUSIONS: Elevated NEAP could be a risk factor for CKD progression. Low intake of fruits and vegetables would increase dietary acid load and might affect the progression of renal dysfunction in Japanese CKD patients.

    DOI： 10.1186/s12882-019-1591-8

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  • 腎移植後に腹膜透析を再導入した一例

    山崎 翔子, 飯田 倫理, 蒲澤 秀門, 忰田 亮平, 山本 卓, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   61 ( 6 )   759 - 759   2019.8

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  • 週1回のGLP-1受容体作動薬エキセナチド使用中に腸管気腫症の増悪を来した1例

    石川 友美, 細島 康宏, 佐藤 健, 塩谷 基, 蒲澤 秀門, 忰田 亮平, 中枝 武司, 和田 庸子, 鈴木 芳樹, 斎藤 亮彦, 成田 一衛

    糖尿病   61 ( 9 )   624 - 624   2018.9

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  • 膜性腎症にMPO-ANCA陽性の半月体形成を伴う糸球体腎炎を合併した一例

    若松 拓也, 蒲澤 秀門, 忰田 亮平, 金子 佳賢, 伊藤 由美, 今井 直史, 成田 一衛

    日本腎臓学会誌   60 ( 6 )   875 - 875   2018.8

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  • Angiotensin receptor blocker vs ACE inhibitor effects on HDL functionality in patients on maintenance hemodialysis. Reviewed

    Kaseda R, Tsuchida Y, Gamboa JL, Zhong J, Zhang L, Yang H, Dikalova A, Bian A, Davies S, Fogo AF, Linton MF, Brown NJ, Ikizler TA, Kon V

    Nutrition, metabolism, and cardiovascular diseases : NMCD   28 ( 6 )   582 - 591   2018.6

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  • Bardoxolone methylによる腎近位尿細管のメガリン調節機構の検討

    吉澤 優太, 桑原 頌治, 細島 康宏, 蒲澤 秀門, 忰田 亮平, 宇賀村 大亮, 後藤 佐和子, 飯田 倫理, 鈴木 芳樹, 成田 一衛, 斎藤 亮彦

    糖尿病   61 ( Suppl.1 )   S - 383   2018.4

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  • 幼少期における米(胚乳)タンパク質の摂取が成熟期の高脂肪食負荷による肥満および肥満関連腎症に及ぼす影響

    樋口 裕樹, 細島 康宏, 蒲澤 秀門, 桑原 頌治, 忰田 亮平, 成田 一衛, 斎藤 亮彦

    糖尿病   61 ( Suppl.1 )   S - 241   2018.4

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  • SGLT2阻害薬ダパグリフロジンの腎近位尿細管細胞における血糖値非依存的なメガリン発現抑制作用

    飯田 倫理, 桑原 頌治, 細島 康宏, 石川 友美, 後藤 佐和子, 蒲澤 秀門, 忰田 亮平, 鈴木 芳樹, 成田 一衛, 斎藤 亮彦

    糖尿病   61 ( Suppl.1 )   S - 382   2018.4

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  • Kidney morphological parameters measured using noncontrast-enhanced steady-state free precession MRI with spatially selective inversion recovery pulse correlate with eGFR in patients with advanced CKD Reviewed

    Tadashi Otsuka, Yoshikatsu Kaneko, Yuya Sato, Ryohei Kaseda, Ryuji Aoyagi, Suguru Yamamoto, Shin Goto, Ichiei Narita

    Clinical and Experimental Nephrology   22 ( 1 )   45 - 54   2018.2

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    DOI： 10.1007/s10157-017-1413-x

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  • Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism. Reviewed International journal

    Kaseda R, Tsuchida Y, Yang HC, Yancey PG, Zhong J, Tao H, Bian A, Fogo AB, Linton MRF, Fazio S, Ikizler TA, Kon V

    BMC nephrology   19 ( 1 )   17 - 17   2018.1

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    BACKGROUND: Our aim was to evaluate lipid trafficking and inflammatory response of macrophages exposed to lipoproteins from subjects with moderate to severe chronic kidney disease (CKD), and to investigate the potential benefits of activating cellular cholesterol transporters via liver X receptor (LXR) agonism. METHODS: LDL and HDL were isolated by sequential density gradient ultracentrifugation of plasma from patients with stage 3-4 CKD and individuals without kidney disease (HDLCKD and HDLCont, respectively). Uptake of LDL, cholesterol efflux to HDL, and cellular inflammatory responses were assessed in human THP-1 cells. HDL effects on inflammatory markers (MCP-1, TNF-α, IL-1β), Toll-like receptors-2 (TLR-2) and - 4 (TLR-4), ATP-binding cassette class A transporter (ABCA1), NF-κB, extracellular signal regulated protein kinases 1/2 (ERK1/2) were assessed by RT-PCR and western blot before and after in vitro treatment with an LXR agonist. RESULTS: There was no difference in macrophage uptake of LDL isolated from CKD versus controls. By contrast, HDCKD was significantly less effective than HDLCont in accepting cholesterol from cholesterol-enriched macrophages (median 20.8% [IQR 16.1-23.7] vs control (26.5% [IQR 19.6-28.5]; p = 0.008). LXR agonist upregulated ABCA1 expression and increased cholesterol efflux to HDL of both normal and CKD subjects, although the latter continued to show lower efflux capacity. HDLCKD increased macrophage cytokine response (TNF-α, MCP-1, IL-1β, and NF-κB) versus HDLCont. The heightened cytokine response to HDLCKD was further amplified in cells treated with LXR agonist. The LXR-augmentation of inflammation was associated with increased TLR-2 and TLR-4 and ERK1/2. CONCLUSIONS: Moderate to severe impairment in kidney function promotes foam cell formation that reflects impairment in cholesterol acceptor function of HDLCKD. Activation of cellular cholesterol transporters by LXR agonism improves but does not normalize efflux to HDLCKD. However, LXR agonism actually increases the pro-inflammatory effects of HDLCKD through activation of TLRs and ERK1/2 pathways.

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  • A Randomized, Double-Blind, Crossover Pilot Trial of Rice Endosperm Protein Supplementation in Maintenance Hemodialysis Patients Reviewed

    Michihiro Hosojima, Hisaki Shimada, Yoshitsugu Obi, Shoji Kuwahara, Ryohei Kaseda, Hideyuki Kabasawa, Hazuki Kondo, Mikio Fujii, Reiko Watanabe, Yoshiki Suzuki, Motoni Kadowaki, Shigeru Miyazaki, Akihiko Saito

    SCIENTIFIC REPORTS   7 ( 1 )   18003   2017.12

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    DOI： 10.1038/s41598-017-18340-8

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  • ECMO装着中の新生児AKI患者にSepxiris60を使用した際、治療開始後にACTの延長をきたした一例

    近藤 友希, 長谷川 進, 谷江 駿矢, 宮内 大輔, 松谷 智佳, 西塔 毅, 忰田 亮平, 蒲澤 秀門, 黒澤 陽一, 山本 卓, 成田 一衛

    新潟急性血液浄化研究会抄録集   4回   3 - 3   2017.11

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  • 維持透析妊婦の周産期心筋症を来した一例

    宮崎 慧, 土田 雅史, 蒲澤 秀門, 保坂 聖子, 忰田 亮平, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   59 ( 6 )   874 - 874   2017.9

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  • Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity Reviewed

    Yoshihisa Hori, Nobumasa Aoki, Shoji Kuwahara, Michihiro Hosojima, Ryohei Kaseda, Sawako Goto, Tomomichi Iida, Shankhajit De, Hideyuki Kabasawa, Reika Kaneko, Hiroyuki Aoki, Yoshinari Tanabe, Hiroshi Kagamu, Ichiei Narita, Toshiaki Kikuchi, Akihiko Saito

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   28 ( 6 )   1783 - 1791   2017.6

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    DOI： 10.1681/ASN.2016060606

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  • Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy Reviewed

    Shankhajit De, Shoji Kuwahara, Michihiro Hosojima, Tomomi Ishikawa, Ryohei Kaseda, Piyali Sarkar, Yusuke Yoshioka, Hideyuki Kabasawa, Tomomichi Iida, Sawako Goto, Koji Toba, Yuki Higuchi, Yoshiki Suzuki, Masanori Hara, Hiroyuki Kurosawa, Ichiei Narita, Yoshiaki Hirayama, Takahiro Ochiya, Akihiko Saito

    DIABETES   66 ( 5 )   1391 - 1404   2017.5

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    DOI： 10.2337/db16-1031

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  • 当院における生体腎移植後の出産症例の経過の検討

    佐藤 勇也, 忰田 亮平, 川村 和子, 田崎 正行, 中川 由紀, 齋藤 和英, 冨田 善彦, 成田 一衛

    日本腎臓学会誌   59 ( 3 )   336 - 336   2017.4

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  • The Assessment of the Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Glucocorticoid-induced Diabetes by Continuous Glucose Monitoring Reviewed

    Yusuke Yata, Michihiro Hosojima, Hideyuki Kabasawa, Tomomi Ishikawa, Ryohei Kaseda, Noriaki Iino, Yoshiki Suzuki, Akihiko Saito, Ichiei Narita

    INTERNAL MEDICINE   56 ( 19 )   2555 - 2562   2017

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    DOI： 10.2169/internalmedicine.8296-16

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  • フルニエ壊疽を合併した透析患者にPMX-DHPが有効であった二例

    永野 敦嗣, 酒巻 裕一, 忰田 亮平, 川村 和子, 若松 彩子, 野澤 由貴子, 佐藤 弘恵, 中枝 武司, 山本 卓, 成田 一衛

    新潟急性血液浄化研究会抄録集   3回   5 - 5   2016.12

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  • ネフローゼ症候群を併発した多中心性キャッスルマン病の1例

    長谷川 絵理子, 酒巻 裕一, 忰田 亮平, 保坂 聖子, 川村 和子, 今井 直史, 伊藤 由美, 後藤 眞, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   58 ( 6 )   789 - 789   2016.8

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  • 循環性免疫複合体が著しく上昇し、低補体血症と急性腎障害を呈した紫斑病性腎炎の1例

    永野 敦嗣, 酒巻 裕一, 後藤 眞, 若松 彩子, 細島 康宏, 忰田 亮平, 川村 和子, 今井 直史, 伊藤 由美, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   58 ( 6 )   801 - 801   2016.8

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  • Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease Reviewed

    Shoji Kuwahara, Michihiro Hosojima, Reika Kaneko, Hiroyuki Aoki, Daisuke Nakano, Taiji Sasagawa, Hideyuki Kabasawa, Ryohei Kaseda, Ryota Yasukawa, Tomomi Ishikawa, Akiyo Suzuki, Hiroyoshi Sato, Shun Kageyama, Takahiro Tanaka, Nobutaka Kitamura, Ichiei Narita, Masaaki Komatsu, Akira Nishiyama, Akihiko Saito

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   27 ( 7 )   1996 - 2008   2016.7

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    DOI： 10.1681/ASN.2015020190

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  • Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial

    Michihiro Hosojima, Ryohei Kaseda, Hazuki Kondo, Mikio Fujii, Masatoshi Kubota, Reiko Watanabe, Naohito Tanabe, Motoni Kadowaki, Yoshiki Suzuki, Akihiko Saito

    BMC Nutrition   2 ( 1 )   2016.5

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    DOI： 10.1186/s40795-016-0065-7

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  • 高トリグリセリド血症に伴う重症急性膵炎にsepXiris(AN69ST)を用いた急性血液浄化療法により救命できた一例

    細島 康宏, 佐藤 容子, 若松 彩子, 松尾 浩司, 忰田 亮平, 川村 和子, 谷江 駿矢, 長谷川 進, 風間 順一郎, 成田 一衛

    新潟急性血液浄化研究会抄録集   2回   6 - 6   2015.12

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  • Reduction of Albuminuria by Sitagliptin Is Associated with Improvement of Renal Proximal Tubular Function in Patients with Type 2 Diabetes Reviewed

    Michihiro Hosojima, Taiji Sasagawa, Hideyuki Kabasawa, Tomomi Ishikawa, Ryohei Kaseda, Yoshiki Suzuki, Ichiei Narita, Hiroyuki Kurosawa, Yoshiaki Hirayama, Akihiko Saito

    DIABETES   64   A151 - A151   2015.6

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  • 皮下多発結節を有しErdheim-Chester病と診断した1例

    遠藤 麻巳子, 高井 千夏, 朝川 勝明, 渡辺 博文, 忰田 亮平, 細島 康宏, 川村 和子, 風間 順一郎, 成田 一衛, 清水 彩子, 苅谷 直之, 梅津 哉

    新潟医学会雑誌   129 ( 5 )   290 - 290   2015.5

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  • Dysfunctional high-density lipoproteins in children with chronic kidney disease Reviewed

    Ryohei Kaseda, Kathy Jabs, Tracy E. Hunley, Deborah Jones, Aihua Bian, Ryan M. Allen, Kasey C. Vickers, Patricia G. Yancey, MacRae F. Linton, Sergio Fazio, Valentina Kon

    METABOLISM-CLINICAL AND EXPERIMENTAL   64 ( 2 )   263 - 273   2015.2

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    DOI： 10.1016/j.metabol.2014.10.020

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  • 還ってきた腎臓 3ヵ月に及ぶ急性血液浄化から離脱しえた全身熱傷に伴う急性腎障害の一例

    伊藤 友美, 大塚 忠司, 渡邉 博文, 高井 千夏, 細島 康宏, 忰田 亮平, 川村 和子, 風間 順一郎

    新潟急性血液浄化研究会抄録集   1回   9 - 9   2014.11

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  • Dysfunctional High-Density Lipoprotein in Patients on Chronic Hemodialysis Reviewed

    Suguru Yamamoto, Patricia G. Yancey, Alp Ikizler, W. Gray Jerome, Ryohei Kaseda, Brian Cox, Aihua Bian, Ayumi Shintani, Agnes B. Fogo, MacRae F. Linton, Sergio Fazio, Valentina Kon

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   60 ( 23 )   2372 - 2379   2012.12

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    DOI： 10.1016/j.jacc.2012.09.013

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  • Significance of Urinary Full-Length and Ectodomain Forms of Megalin in Patients With Type 2 Diabetes Reviewed

    Shinya Ogasawara, Michihiro Hosojima, Ryohei Kaseda, Hideyuki Kabasawa, Keiko Yamamoto-Kabasawa, Hiroyuki Kurosawa, Hiroyoshi Sato, Noriaki Iino, Tetsuro Takeda, Yoshiki Suzuki, Ichie Narita, Kunihiro Yamagata, Yasuhiko Tomino, Fumitake Gejyo, Yoshiaki Hirayama, Sakari Sekine, Akihiko Saito

    DIABETES CARE   35 ( 5 )   1112 - 1118   2012.5

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    DOI： 10.2337/dc11-1684

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  • Macrophage Polarization by Angiotensin II-Type 1 Receptor Aggravates Renal Injury-Acceleration of Atherosclerosis Reviewed

    Suguru Yamamoto, Patricia G. Yancey, Yiqin Zuo, Li-Jun Ma, Ryohei Kaseda, Agnes B. Fogo, Iekuni Ichikawa, MacRae F. Linton, Sergio Fazio, Valentina Kon

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   31 ( 12 )   2856 - U277   2011.12

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    DOI： 10.1161/ATVBAHA.111.237198

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  • Role of Megalin and Cubilin in the Metabolism of Vitamin D-3 Reviewed

    Ryohei Kaseda, Michihiro Hosojima, Hiroyoshi Sato, Akihiko Saito

    THERAPEUTIC APHERESIS AND DIALYSIS   15   14 - 17   2011.6

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    DOI： 10.1111/j.1744-9987.2011.00920.x

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  • Megalin is downregulated via LPS-TNF-alpha-ERK1/2 signaling pathway in proximal tubule cells Reviewed

    Aya Takeyama, Hiroyoshi Sato, Taeko Soma-Nagae, Hideyuki Kabasawa, Akiyo Suzuki, Keiko Yamamoto-Kabasawa, Michihiro Hosojima, Reika Kaneko, Fumie Higuchi, Ryohei Kaseda, Shinya Ogasawara, Ichiei Narita, Akihiko Saito

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   407 ( 1 )   108 - 112   2011.4

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    DOI： 10.1016/j.bbrc.2011.02.118

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  • Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes. Reviewed

    Saito A, Kaseda R, Hosojima M, Sato H

    International journal of nephrology   2011   957164   2010.12

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  • Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells Reviewed

    Kiyoko Hosaka, Tetsuro Takeda, Noriaki Iino, Michihiro Hosojima, Hiroyoshi Sato, Ryohei Kaseda, Keiko Yamamoto, Asako Kobayashi, Fumitake Gejyo, Akihiko Saito

    KIDNEY INTERNATIONAL   75 ( 12 )   1308 - 1315   2009.6

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    DOI： 10.1038/ki.2009.85

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  • Regulation of Megalin Expression in Cultured Proximal Tubule Cells by Angiotensin II Type 1A Receptor- and Insulin-Mediated Signaling Cross Talk Reviewed

    Michihiro Hosojima, Hiroyoshi Sato, Keiko Yamamoto, Ryohei Kaseda, Taeko Soma, Asako Kobayashi, Akiyo Suzuki, Hideyuki Kabasawa, Aya Takeyama, Kenji Ikuyama, Noriaki Iino, Akira Nishiyama, Thomas J. Thekkumkara, Tetsuro Takeda, Yoshiki Suzuki, Fumitake Gejyo, Akihiko Saito

    ENDOCRINOLOGY   150 ( 2 )   871 - 878   2009.2

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    DOI： 10.1210/en.2008-0886

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  • Megalin-mediated endocytosis of cystatin C in proximal tubule cells Reviewed

    Ryohei Kaseda, Noriaki Iino, Michihiro Hosojima, Tetsuro Takeda, Kiyoko Hosaka, Asako Kobayashi, Keiko Yamamoto, Akiyo Suzuki, Ayaka Kasai, Yoshiki Suzuki, Fumitake Gejyo, Akihiko Saito

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   357 ( 4 )   1130 - 1134   2007.6

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    DOI： 10.1016/j.bbrc.2007.04.072

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  • Functional characterization of a novel missense CLCN5 mutation causing alterations in proximal tubular endocytic machinery in Dent's disease Reviewed

    Atsuhito Tanuma, Hiroyoshi Sato, Tetsuro Takeda, Michihiro Hosojima, Hiroaki Obayashi, Hitomi Hama, Noriaki Iino, Kiyoko Hosaka, Ryohei Kaseda, Naofumi Imai, Mitsuhiro Ueno, Maya Yamazaki, Kenji Sakimura, Fumitake Gejyo, Akihiko Saito

    NEPHRON PHYSIOLOGY   107 ( 4 )   P87 - P97   2007

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    DOI： 10.1159/000111253

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  • Functional characterization of a novel missense CLCN5 mutation causing alterations in proximal tubular endocytic machinery in Dent's disease. Reviewed

    Tanuma A, Sato H, Takeda T, Hosojima M, Obayashi H, Hama H, Iino N, Hosaka K, Kaseda R, Imai N, Ueno M, Yamazaki M, Sakimura K, Gejyo F, Saito A

    Nephron. Physiology   107 ( 4 )   p87 - 97   2007

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  • Role of megalin, a proximal tubular endocytic receptor, in the pathogenesis of diabetic and metabolic syndrome-related nephropathies: protein metabolic overload hypothesis Reviewed

    A Saito, T Takeda, H Hama, Y Oyama, K Hosaka, A Tanuma, R Kaseda, M Ueno, S Nishi, S Ogasawara, F Gondaira, Y Suzuki, F Gejyo

    NEPHROLOGY   10   S26 - S31   2005.10

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    DOI： 10.1111/j.1440-1797.2005.00453.x

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  • Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules Reviewed

    Y Oyama, T Takeda, H Hama, A Tanuma, N Iino, K Sato, R Kaseda, ML Ma, T Yamamoto, H Fujii, JJ Kazama, S Odani, Y Terada, K Mizuta, F Gejyo, A Saito

    LABORATORY INVESTIGATION   85 ( 4 )   522 - 531   2005.4

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    DOI： 10.1038/labinvest.3700240

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  • Significance of proximal ribular metabolism of advanced glycation end products in kidney diseases Reviewed

    A Saito, T Takeda, K Sato, H Hama, A Tanuma, R Kaseda, Y Suzuki, F Gejyo

    MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE   1043   637 - 643   2005

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    DOI： 10.1196/annals.1333.072

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  • Adult-onset leukoencephalopathy with vanishing white matter with a missense mutation in EIF2B5. Reviewed

    Ohtake H, Shimohata T, Terajima K, Kimura T, Jo R, Kaseda R, Iizuka O, Takano M, Akaiwa Y, Goto H, Kobayashi H, Sugai T, Muratake T, Hosoki T, Shioiri T, Okamoto K, Onodera O, Tanaka K, Someya T, Nakada T, Tsuji S

    Neurology   62 ( 9 )   1601 - 1603   2004.5

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Books

  • 『糖尿病・内分泌代謝科』 特集/水バランスの異常としてのdysnatremia

    忰田亮平, 成田一衛（ Role： Contributor ,  8. ネフローゼ症候群による低Na血症の病態と治療）

    科学評論社  2023.5 

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  • 臨床薬理の進歩

    臨床薬理研究振興財団, 藤村, 昭夫, 大戸, 茂弘, 上村, 尚人

    臨床薬理研究振興財団  2020.6 

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    Total pages：196p   Language：Japanese

    CiNii Books

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  • 腎臓内科・泌尿器科

    忰田 亮平（ Role： Contributor ,  腎泌尿器の難病研究）

    科学評論社  2019 

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  • 臨床検査増刊号「重要疾患レッドページ」

    忰田 亮平（ Role： Contributor ,  ネフローゼ症候群）

    医学書院  2019 

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  • 腎と透析 ベッドサイド検査事典

    忰田 亮平（ Role： Contributor ,  腎静態シンチグラフィ一（99mTc-DMSA法）, 腎動態シンチグラフィ一（99mTc-DTPA法，99mTc-MAG3法））

    東京医学社  2018 

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  • 「内分泌・糖尿病・代謝内科」特集/ガイドラインに基づく糖質調整とその実際

    忰田 亮平（ Role： Contributor ,  腎症・脂質代謝異常と糖質調整）

    科学評論社  2016 

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  • Annual Review 腎臓 2015

    忰田 亮平（ Role： Contributor ,  B.尿細管・間質障害 (1) タンパク質代謝臓器としての腎）

    中外医学社  2015 

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  • Medical Practice 2015年(vol.32) 臨時増刊号 病態生理と症例から学ぶ輸液ガイド

    忰田 亮平（ Role： Contributor ,  15 慢性腎炎、ネフローゼ症候群患者の輸液法）

    文光堂  2015 

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  • 腎と透析

    忰田 亮平（ Role： Contributor ,  尿潜血・血尿・色素尿からわかる腎臓病）

    東京医学社  2015 

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MISC

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Presentations

  • 23Na-MRIを用いた2型糖尿病モデルマウスの腎臓のNa+濃度の検討

    中川裕介, 忰田亮平, 拝師智之, 佐々木進, 成田一衛

    第64回日本腎臓学会学術総会  2021.6 

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    Event date： 2021.6

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  • 23Na-MRIを用いた腎臓内の対向流増幅系の検討

    忰田亮平

    第48回日本磁気共鳴医学会大会 

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    Event date： 2020.9 - 2020.10

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  • 23Na-MRIを用いた腎臓の病態生理の検討

    忰田亮平

    第63回日本腎臓学会学術総会 

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    Event date： 2020.8

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  • Sodium Magnetic Resonance Imaging Shows Impairment of the Counter-Current Multiplication System in the Diabetic Model Mice Kidney

    Yusuke Nakagawa, Ryohei Kaseda, Yuya Suzuki, Yasuhiko Terada, Tomoyuki Haishi, Susumu Sasaki, Ichiei Narita

    American Society of Nephrology Kidney Week 2022  2022.11 

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  • Importance of Promoting CKD Health Literacy in the Younger Generation: Data From the Niigata Prefectural Health and Nutrition Survey and Questionnaire Survey of High School Students in Japan

    Yuya Suzuki, Ryohei Kaseda, Yusuke Nakagawa, Mizuki Takeuchi, Junko Nakamura, Minako Wakasugi, Ichiei Narita

    American Society of Nephrology Kidney Week 2022  2022.11 

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  • Establishment of a virtual slide system linking to the Japan Renal Biopsy Registry International conference

    忰田 亮平

    American Society of Nephrology Annual Meeting Kidney Week 2019. Washington DC  2019.11 

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    Language：English   Presentation type：Poster presentation  

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  • バーチャルスライドの登録状況報告

    忰田 亮平

    第62回日本腎臓学会学術総会 名古屋市  2019.6 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Plant versus animal protein improves anti-inflammatory effects of HDL and lessens CKD-induced atherosclerosis

    忰田 亮平

    第61回日本腎臓学会総会 新潟県 新潟市  2018.6 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Plant protein compared to animal protein improves anti-inflammatory effects of HDL and lessens CKD-induced atherosclerosis International conference

    忰田 亮平

    ISN FRONTIERS MEETINGS Tokyo, Japan  2018.2 

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    Language：English   Presentation type：Poster presentation  

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  • Plant versus animal protein improves anti-inflammatory effects of HDL and lessens CKD-induced atherosclerosis International conference

    忰田 亮平

    American Society of Nephrology Annual Meeting Kidney Week 2017. New Orleans, LA  2017.10 

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    Language：English   Presentation type：Poster presentation  

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  • Differential effects of angiotensin II receptor blocker (ARB) vs ACE inhibitor (ACEI) on HDL functionality in patients on maintenance hemodialysis (MHD) International conference

    忰田 亮平

    American Society of Nephrology Annual Meeting Kidney Week 2016.Chicago,IL  2016.11 

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    Language：English   Presentation type：Poster presentation  

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  • レニン‐アンジオテンシン系(RAS)阻害薬の血液透析患者(HD)HDLへの効果

    忰田 亮平

    第61回日本透析医学会学術集会・総会 大阪府 大阪市  2016.6 

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    Language：Japanese   Presentation type：Poster presentation  

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  • Efficacy of nutrition counseling intake restriction in chronic kidney disease patients-Niigata part of SOFT-J(study on Rejional variation of FROM-J intervention by Japanese Society of Nephrology) International conference

    忰田 亮平

    American Society of Nephrology Annual Meeting Kidney Week 2015. San Diego,CA  2015.11 

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    Language：English   Presentation type：Poster presentation  

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  • CKD患者に対するたんぱく質摂取制限指導の検証：SOFT-J study

    忰田 亮平

    第58回日本腎臓学会学術集会 愛知県 名古屋市  2015.6 

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    Language：Japanese   Presentation type：Poster presentation  

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  • Disruption of Macrophage Lipid and Inflammatory Handling and Effects of Liver X Recepter(LXR)Agonism

    忰田 亮平

    American Society of Nephrology Kidney Week 2014 Philadelphia, PA  2014.11 

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    Language：English  

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  • Childhood Chronic Kidney Disease (CKD) Impairs Normal Vasoprotective Functions of High Density Lipoprotein (HDL) International conference

    忰田 亮平

    American Society of Nephrology Kidney Week 2013 Atlanta, GA  2013.11 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Chronic Kidney Disease (CKD) in Children Impairs Normal Protective Functions of High Density Lipoprotein (HDL) International conference

    忰田 亮平

    Pediatric Academic Societies Annual Meeting 2013. Washington DC  2013.5 

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    Language：English   Presentation type：Poster presentation  

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  • Chronic Kidney Disease (CKD) in Children Impairs Normal Protective Functions of High Density Lipoprotein (HDL) International conference

    忰田 亮平

    American Society of Nephrology 45th Annual Meeting. San Diego, CA  2012.11 

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    Language：English   Presentation type：Poster presentation  

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Industrial property rights

  • 画像処理装置、画像処理方法、及びプログラム

    忰田 亮平, 佐々木 進, 成田 一衛, 拝師 智之

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    Applicant：国立大学法人 新潟大学

    Application no：特願2020-127377  Date applied：2020.7

    Patent/Registration no：特許第7474498号  Date registered：2024.4 

    J-GLOBAL

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Awards

  • TOP10% poster

    2018.2   ISN FRONTIERS MEETING   Plant versus animal protein improves anti-inflammatory effects of HDL and lessens CKD-induced atherosclerosis

    忰田 亮平

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  • Top Oral Abstracts by Trainees

    2013.11   第46回米国腎臓学会総会   Childhood Chronic Kidney Disease (CKD) Impairs Normal Vasoprotective Functions of High Density Lipoprotein (HDL)

    忰田 亮平

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  • The ASPN Presentation Award

    2013.5   米国小児科学会議 2013   Chronic Kidney Disease (CKD) in Children Impairs Normal Protective Functions of High Density Lipoprotein (HDL)

    忰田 亮平

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  • AEA受賞

    2010.12   Advans研究会   近位尿細管上皮細胞エンドサイトーシス受容体メガリンの発現調節機構

    忰田 亮平

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  • CKD award2010 ポスター発表奨励賞

    2010.11   メタボリックシンドローム関連腎症の発症・進展機序におけるメガリンの関与

    忰田 亮平

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Research Projects

  • 難治性腎障害に関する調査研究 研究分担者

    2023.4 - 2026.3

    System name：厚生労働科学研究補助金 難治性疾患等政策研究事業

    Awarding organization：厚生労働省

    猪阪善隆

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    Authorship：Coinvestigator(s) 

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  • 23Na-MRIの臨床応用を模索した研究開発

    2022.10 - 2023.9

    System name：調査研究助成金

    Awarding organization：公益財団法人鈴木謙三記念医科学応用研究財団

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    Authorship：Principal investigator 

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  • 23Na-MRIを用いたネフローゼ症候群の病態生理の解析

    Grant number：20K08586

    2020.4 - 2023.3

    System name：科学研究費助成事業 基盤研究(C)

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    忰田 亮平, 成田 一衛, 細島 康宏, 斎藤 亮彦

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    腎臓内でのNa+ハンドリングの可視化は、腎臓領域の研究での悲願であり、特に、ネフローゼ症候群では、Na+の貯留と浮腫の成因として、underfillingとoverfillingの機序が提唱されているが、腎臓内のNa+の全体像を明らかにできる方法は今までなかった。申請者らは、マウスのごく小さな腎臓に対して、23Na-MRI（磁気共鳴映像法）を用いて23Naをもとにした画像化に成功し、水の効率的な再吸収が可能となる対向流増幅系のNa+の濃度勾配・Na+の貯留の状態を可視化した。この23Na-MRI画像をもとに、今まで理解できなかったネフローゼ症候群における「腎臓全体のNa+のハンドリング・Na+の貯留」と「Na+の再吸収に関わるチャネル・トランスポーター」の関係を明らかにすることで、病態生理の解明を試みる。腎臓全体でのネフローゼ症候群のNa+の再吸収に関わる機構の異常を解明することを目的とする。①ネフローゼモデルマウス（NEP25マウス）を用いて、ネフローゼ症候群といった病的状態では、腎臓内のNa+再吸収に関わる作用点 (チャネル・トランスポーター)がどのように変化するか明らかにする。②さらに、Na+の再吸収に影響する薬剤、具体的には、副腎皮質ステロイド、SGLT2阻害薬、RAS阻害薬、トルバプタン、ミネラルコルチコイド受容体(MR)拮抗薬、ヒト心房性ナトリウム利尿ペプチド(hANP)、バソプレッシン等について検討する。③腎臓内Agt、AngII量や挙動と画像所見を元にしたNa+の再吸収機構の関連について検討する。

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  • The role of abnormal mucosal immunity in renal senescence

    Grant number：19H03674

    2019.4 - 2023.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17030000 （ Direct Cost: \13100000 、 Indirect Cost：\3930000 ）

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  • 多彩な解析情報を得る機能的NMRの生組織への展開と生態の所望部位を可視化するMRIの開発 研究参加者

    2018.8 - 2021.3

    System name：AMED 医療分野成果研究事業（先端計測分析技術・機器開発プログラム）

    Awarding organization：文部科学省

    佐々木 進

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    Grant type：Competitive

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  • ネフローゼ症候群の新規診断法の確立 研究参加者

    2018.4 - 2021.3

    System name：AMED 難治性疾患実用化研究事業（診療に直結するエビデンス創出研究）

    Awarding organization：文部科学省

    丸山 彰一

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    Grant type：Competitive

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  • メガリンの機能抑制によるスフィンゴシン1-リン酸を介した動脈硬化軽減作用の検証

    2018.4 - 2019.3

    System name：学術研究助成金

    Awarding organization：新潟県医師会

    忰田 亮平

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    Authorship：Principal investigator  Grant type：Competitive

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  • 難治性腎障害に関する調査研究 研究分担者

    2017.4 - 2020.3

    System name：科学研究費補助金

    Awarding organization：厚生労働省

    成田 一衛

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    Grant type：Competitive

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  • SGLT2阻害薬の腎保護機序と診断法

    2017.4 - 2018.3

    System name：研究奨励金

    Awarding organization：臨床薬理研究振興財団

    忰田 亮平

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    Authorship：Principal investigator  Grant type：Competitive

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  • メガリンを標的とした腎機能温存・再生療法の開発 研究分担者

    2016.4 - 2019.3

    System name：AMED 腎疾患実用化事業

    Awarding organization：文部科学省

    斎藤 亮彦

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    Grant type：Competitive

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  • メガリンを介した心腎関連機序とﾀﾝﾊﾟｸ質代謝の関連

    2015.10 - 2017.9

    System name：研究助成

    Awarding organization：(公財)万有生命科学振興国際交流財団

    忰田 亮平

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    Authorship：Principal investigator  Grant type：Competitive

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  • 新しい心腎連関機序：メガリンの発現抑制による腎保護を介した動脈硬化軽減作用の検証

    2015.4 - 2018.3

    System name：科学研究費助成事業(学術研究助成基金助成金) 若手研究(B)

    Awarding organization：文部科学省

    忰田 亮平

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    Authorship：Principal investigator  Grant type：Competitive

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  • New mechanism of cardio-renal association: Evaluation of the effect of megalin inhibition to the atherosclerosis through the renal protection

    Grant number：15K19447

    2015.4 - 2018.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    Kaseda Ryohei

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    Megalin・ApoE double KO mice have been successfully established. 21-week-old Megalin・ApoE double KO mice have a tendency to have decreased atherosclerotic lesion of the aortas compared with ApoE KO mice. In our studies to evaluate the mechanisms of atherosclerosis in kidney injury, we have investigated the impact of nutrition intake.After 10-week-old Apo E KO mice underwent uninephrectomy, these mice were pair-fed with a usual casein (animal protein)-based diet or rice protein-based diet for 7 weeks. Compared with the animal protein-based diet, the plant protein-based diet significantly reduced atherosclerosis accelerated by renal mass reduction.

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Social Activities

  • 脂質異常症と動脈硬化症について

    Role(s)： Lecturer

    新潟市  第25期（2019年）にいがた市民大学  2019.7

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  • イオンシネマ健康フェスティバル 健康な生活を送るために

    Role(s)： Lecturer

    2017.9

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Media Coverage

  • みんなの診察室. 新潟日報 Newspaper, magazine

    2018.5

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  • メガリンの機能抑制によるスフィンゴシン１-リン酸を介した動脈硬化軽減作用の検証

    新潟県医師会報  2018

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