2024/10/07 更新

写真a

コダマ サトル
児玉 暁
KODAMA Satoru
所属
医歯学総合研究科 特任准教授
職名
特任准教授
外部リンク

学位

  • スポーツ医学博士 ( 2008年3月   筑波大学 )

研究キーワード

  • 予防疫学

  • メタ解析

研究分野

  • ライフサイエンス / 栄養学、健康科学

  • 情報通信 / 生命、健康、医療情報学

経歴

  • 新潟大学   医歯学総合研究科   特任准教授

    2017年4月 - 現在

  • 新潟大学   医歯学総合研究科   特任助教

    2014年7月 - 2017年3月

 

論文

  • 1474-P: Cross-Sectional and Longitudinal Relationships between Detailed Family History (FH) of Type 2 Diabetes Mellitus (T2DM), Hypertension (HT), and Dyslipidemia (DL) and Prevalence of Each Disorder

    IZUMI IKEDA, KAZUYA FUJIHARA, YASUNAGA TAKEDA, MARIKO HATTA, SIJIA WU, SATORU KODAMA, YASUMICHI MORI, TAKASHI KADOWAKI, RITSUKO YAMAMOTO-HONDA, YASUJI ARASE, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    A FH of T2DM, HT, and DL are known risk factors; however, few studies have compared the impact of a FH of the 3 diseases in the same population. We examined the impact of a detailed FH of these conditions (i.e., in fathers, mothers, siblings and grandparents) on their prevalence and incidence in the study population. Data on 41,931 participants who underwent health checkups were examined and the results of a logistic regression and (Cox regression model in the same cohort were examined. Results of the cross-sectional study showed that odds ratios increased with the degree of a positive FH for all three diseases. Furthermore, in T2DM, the group with a three-generation positive FH was approximately 20 times larger than the control group which had no FH (Figure). In the longitudinal study, FH had a strong influence on the incidence of T2DM, HT, and DL, in that order, with a hazard ratio of 2.40 (1.93-2.98) for T2DM. A detailed FH was extremely useful for both quantitative screening for each disease and predicting the incidence of the three diseases, especially T2DM, for which a high risk was indicated in multiple generations with overlapping of positivity for a particular disease.

    <p></p> Disclosure

    I. Ikeda: None. K. Fujihara: None. Y. Takeda: None. M. Hatta: None. S. Wu: None. S. Kodama: None. Y. Mori: None. T. Kadowaki: None. R. Yamamoto-Honda: None. Y. Arase: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    DOI: 10.2337/db24-1474-p

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  • 1148-P: Trajectories of Abnormalities in Metabolic Parameters in Japanese Adolescents and Young Adults

    IZUMI IKEDA, KAZUYA FUJIHARA, HARUKA SHIOZAKI, SAKIKO Y. MORIKAWA, CHIKA HORIKAWA, YASUNAGA TAKEDA, HAJIME ISHIGURO, TAKAHO YAMADA, SATORU KODAMA, YOHEI OGAWA, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Childhood obesity mostly transitions into adulthood and leads to non-communicable diseases such as type 2 diabetes and metabolic syndrome. We aimed to examine individual-level transitions in metabolic parameters during adolescence and young adulthood. We analyzed metabolic parameters in 523 participants (311 males) who underwent health examinations at the ages of 14 y (8th grade) and 20 y. Weight status was assessed by the International Obesity Task Force at 14 y and by BMI (thinness: &amp;lt;18.5; normal: 18.5-24.9; obesity: ≥25.0) at 20 y. HbA1c ≥5.7% was defined as high. Clustered metabolic risk score (CMR) was calculated by summing the sex-age specific Z-scores of each metabolic factor (mean arterial pressure, non-HDLC, and HbA1c) with ≥1 SD defined as high. Among participants who were obese at 14 y, 56% of males and 29% of females remained obese at 20 y. In both sexes, 30-50% had high HbA1c and 30-50% had high CMR as tracked from adolescence to adulthood (table). Furthermore, the high CMR of obese females increased markedly from about 20% at 14 y to 50% at 20 y. In addition, 60% of females who were obese at both 14 y and 20 y had high HbA1c at 20 y. Results suggested the importance of lifestyle interventions from childhood, as about half of the high metabolic parameters observed in adolescents were tracked into adulthood, and obesity complications, which were rarely shown at 14 y, appeared in many at age 20 y.

    <p></p> Disclosure

    I. Ikeda: None. K. Fujihara: None. H. Shiozaki: None. S.Y. Morikawa: None. C. Horikawa: None. Y. Takeda: None. H. Ishiguro: None. T. Yamada: None. S. Kodama: None. Y. Ogawa: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    DOI: 10.2337/db24-1148-p

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  • 1666-P: Effect of Obesity in Family History (FH) on the Prevalence of Type 2 Diabetes Mellitus (T2DM), Hypertension (HT), and Dyslipidemia (DL)

    IZUMI IKEDA, KAZUYA FUJIHARA, YASUNAGA TAKEDA, CHIKA HORIKAWA, SATORU KODAMA, EFREM D. FERREIRA, YASUMICHI MORI, TAKASHI KADOWAKI, RITSUKO YAMAMOTO-HONDA, YASUJI ARASE, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Heritability and obesity are strongly associated with the prevalence of T2DM, HT, and DL. We compared the effects of an FH of T2DM, HT, and DL combined with obesity on the prevalence of each in the same population. Of 41931 participants who underwent health checkups, the effects of an FH and BMI on the prevalence of those conditions were analyzed cross-sectionally. Prevalences of T2DM, HT, and DL were 5%, 20%, and 48%, respectively. Logistic regression analysis showed that ORs increased for all three as the number of FH positive cases increased and was most pronounced for T2DM. An FH of obesity and increased BMI were additively associated with the prevalence of the three diseases compared to BMI 20.0-21.9 and no positive FH (Fig. A). In addition, the combination of the number of family members with FH positivity (0,1, 2, ≥3) and obesity was additively associated with an increased FH of the three diseases compared to non-obesity and no FH of any of these diseases (Fig. B). For T2DM, the OR increased sharply in non-obese participants when the number of those with an FH of T2DM was ≥3 (14.4 [8.88-23.5]), but in obese participants the OR increased sharply when the number of those with an FH of T2DM was 2 (12.2 [8.85-16.9]) (Fig. B). Results suggest that, especially for T2DM, avoidance of obesity may be effective in reducing the prevalence of these disorders in those with many FH-positive family members.

    <p></p> Disclosure

    I. Ikeda: None. K. Fujihara: None. Y. Takeda: None. C. Horikawa: None. S. Kodama: None. E.D. Ferreira: None. Y. Mori: None. T. Kadowaki: None. R. Yamamoto-Honda: None. Y. Arase: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    DOI: 10.2337/db24-1666-p

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  • 1259-P: Relationship between Number of Multiple Risk Factors and Functional Disability (FD) in Those With and Without Diabetes Mellitus (DM)

    HARUKA SHIOZAKI, KAZUYA FUJIHARA, KAHORI TSURUOKA, IZUMI IKEDA, MASARU KITAZAWA, YASUHIRO MATSUBAYASHI, MASAHIKO YAMAMOTO, TAKAHO YAMADA, SATORU KODAMA, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Although control of multiple risk factors is essential to prevent FD with and without DM, longitudinal studies are scarce that directly and quantitatively compare effects of such control. Thus, we assessed whether reaching multifactorial targets for HbA1c, blood pressure, non-HDLC, and lifestyle risks such as smoking and no physical activity are associated with FD in those with and without DM.

    Enrolled were 9652 Japanese aged 39-98 y. FD was defined based on the Japanese long-term care insurance system, and targets were based on ADA and Japanese guidelines.

    Of 8,861 non-DM persons, 6.3, 25.2 and 49.1% were on target for 0-2, 3 and 4 factors, respectively. Of 791 persons with DM, 12.4, 68.0 and 19.3% were on target for 0-2, 3-4 and 5 factors, respectively.

    Multivariate Cox analysis showed increased FD with decreased targets reached regardless of DM (Table, upper). Compared with people with non-DM who achieved 4 targets, non-DM persons who achieved 0 to 2 targets and DM persons who achieved 3 to 4 targets had nearly twice the incidence of FD (Table, lower). Moreover, people with DM who achieved only 0 to 2 targets had an approximately 4 times higher incidence of FD (Table, lower). Control of modifiable risk factors was effective regardless of DM. Achievement of all 5 targets among people with DM may reduce FD to the same level as in non-DM persons who achieved all 4 targets.

    <p></p> Disclosure

    H. Shiozaki: None. K. Fujihara: None. K. Tsuruoka: None. I. Ikeda: None. M. Kitazawa: None. Y. Matsubayashi: None. M. Yamamoto: None. T. Yamada: None. S. Kodama: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    Funding

    the Japan Society for the Promotion of Science (21K11569); Daiwa Securities Health Foundation

    DOI: 10.2337/db24-1259-p

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  • 詳細な家族歴が2型糖尿病,高血圧,脂質異常症の有病と発症に与える影響の横断縦断的検討

    池田 和泉, 五十嵐 理沙, 藤原 和哉, 武田 安永, 松林 泰弘, 児玉 暁, 山田 貴穂, 森 保道, 門脇 孝, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   67 ( Suppl.1 )   S - 194   2024年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

    Masahiro Ishizawa, Kazuya Fujihara, Junko Yachida, Izumi Ikeda, Takaaki Sato, Takaho Yamada, Ayako Kobayashi, Shiro Tanaka, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Minoru Tashiro, Satoru Kodama, Kiminori Kato, Hirohito Sone

    Journal of Bone Metabolism   31 ( 1 )   21 - 30   2024年2月

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    掲載種別:研究論文(学術雑誌)  

    Background: No consensus exists regarding which anthropometric measurements are related to bone mineral density (BMD), and this relationship may vary according to sex and age. A large Japanese cohort was analyzed to provide an understanding of the relationship between BMD and anthropometry while adjusting for known confounding factors. Methods: Our cohort included 10,827 participants who underwent multiple medical checkups including distal forearm BMD scans. Participants were stratified into four groups according to age (≥50 years or <50 years) and sex. The BMD values were adjusted for confounding factors, after which single and partial correlation analyses were performed. The prevalence of osteopenia was plotted for each weight index (weight or body mass index [BMI]) class. Results: Cross-sectional studies revealed that weight was more favorably correlated than BMI in the older group (R=0.278 and 0.212 in men and R=0.304 and 0.220 in women, respectively), whereas weight and BMI were weakly correlated in the younger age groups. The prevalence of osteopenia exhibited a negative linear relationship with weight among older women ≥50 years of age, and an accelerated increase was observed with decreasing weight in older men weighing <50 kg and younger women weighing <60 kg. When weight was replaced with BMI, the prevalence was low in most subgroups classified by weight. Conclusions: Weight, rather than BMI, was the most important indicator of osteopenia but it might not be predictive of future bone loss.

    DOI: 10.11005/jbm.2024.31.1.21

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  • 血糖コントロールと妊娠合併症リスクとの量反応関係メタ回帰分析

    児玉 暁, 山田 貴穂, 柳生田 紀子, 谷内 洋子, 堀川 千嘉, 大澤 妙子, 北澤 勝, 藤原 和哉, 西島 浩二, 曽根 博仁

    糖尿病と妊娠   23 ( 3 )   S - 109   2023年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病・妊娠学会  

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  • 糖代謝異常妊娠関連ガイドラインの共通化を目指して 日本糖尿病学会から 「糖尿病診療ガイドライン2024」について

    山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病と妊娠   23 ( 3 )   S - 74   2023年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病・妊娠学会  

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  • 血糖コントロールと妊娠合併症リスクとの量反応関係メタ回帰分析

    児玉 暁, 山田 貴穂, 柳生田 紀子, 谷内 洋子, 堀川 千嘉, 大澤 妙子, 北澤 勝, 藤原 和哉, 西島 浩二, 曽根 博仁

    糖尿病と妊娠   23 ( 3 )   S - 109   2023年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病・妊娠学会  

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  • 網膜症 2型糖尿病男性におけるアルコール摂取と重症糖尿病眼疾患発症の関連

    山本 正彦, 藤原 和哉, 長谷部 日, 山田 万祐子, 矢口 雄大, 大澤 妙子, 岩永 みどり, 児玉 暁, 山田 貴穂, 曽根 博仁

    糖尿病合併症   37 ( Suppl.1 )   135 - 135   2023年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • Relationship between the magnitude of body mass index reductions and remission in patients with type 2 diabetes in real world settings: Analysis of Nationwide Patient Registry in Japan (JDDM74). 査読 国際誌

    Fujihara K, Khin L, Murai K, Yamazaki Y, Tsuruoka K, Yagyuda N, Yamazaki K, Maegawa H, Tanaka S, Kodama S, Sone, H, JDDM Study Group

    Diabetes Obes Metab   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: To determine the association between the magnitude of weight loss and incidence of remission according to baseline characteristics in patients with diabetes in clinical settings. METHODS: In total, 39 676 Japanese patients with type 2 diabetes aged ≥18 years with glycated haemoglobin (HbA1c) ≥6.5% and/or glucose-lowering drug prescription were identified from databases of specialists' clinics from 1989 and followed until September 2022. Remission was diagnosed as maintaining HbA1c <6.5% at least 3 months after cessation of a glucose-lowering drug. Factors associated with remission were evaluated by logistic regression analysis according to weight change in 1 year (i.e. ≥10%, 7.0-9.9%, 3.0-6.9% reduction, <3% change and ≥3.0% increase). RESULTS: During the study period, 3454 remissions occurred. The rates of remission were higher in the group with the greatest reduction of body mass index (BMI) in any category examined (i.e. baseline BMI, HbA1c, duration of diabetes and treatment). The incidences of remission per 1000 person-years were about 25 and 50, respectively, for those with BMI ≥22.5 and reductions in BMI of 7.0-9.9% and ≥10% in 1 year. Remissions per 1000 person-years were 99.2 and 91.8, respectively, for those with baseline HbA1c of 6.5-6.9 and a 10% BMI reduction and those not taking glucose-lowering drugs accompanied by a 10% BMI reduction. CONCLUSIONS: Modest weight losses of 3.0-7.9% were significantly associated with remission, but a minimum of 10% weight loss would be required in addition to an early diagnosis to achieve a 10% remission rate in clinical settings. Our results implied that remission may be expected with a relatively lower BMI in an Asian population compared with that was reported in Western populations if accompanied by weight loss.

    DOI: 10.1111/dom.15206

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  • Retrospective cohort study to examine the association between serum amylase and the incidence of type 2 diabetes mellitus, Toranomon Hospital Health Management Center Study 23 (TOPICS 23). 国際誌

    Izumi Ikeda, Kazuya Fujihara, Taeko Osawa, Yasunaga Takeda, Mariko Hatta, Yasuhiro Matsubayashi, Satoru Kodama, Yasumichi Mori, Takashi Kadowaki, Ritsuko Honda, Yasuji Arase, Hirohito Sone

    BMJ open diabetes research & care   11 ( 4 )   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Low serum amylase values are cross-sectionally associated with the prevalence of type 2 diabetes mellitus (T2DM) but have not been shown to be longitudinally associated with its incidence. This retrospective cohort (ie, historical cohort) study aimed to examine the association of previously lowered levels of serum amylase with incident T2DM. RESEARCH DESIGN AND METHODS: Examined were 8316 individuals who had annual health examinations for 6 years (ie, 7 times) at the Toranomon Hospital Health Management Center. The trajectory of serum amylase as the study exposure was classified into two elements: (1) serum amylase level at entry and (2) change in serum amylase, which was expressed as the annual change rate. The annual change rate was calculated by dividing the change in the amylase values according to follow-up periods. Regression analyses were performed to examine the association between low and decreased levels of serum amylase and the incidence of T2DM. RESULTS: Analyzed were 6917 individuals who had not developed T2DM within 1 year after cohort entry. T2DM thereafter occurred in 1021 patients. Cox regression indicated that the adjusted HR (95% CI) for incident T2DM for amylase ≤57 IU/L (quintile (Q) 1) was 0.97 (0.84 to 1.13) compared with amylase ≥58 IU/L (Q2-Q5). Logistic regression indicated that the adjusted OR (95% CI) for an annual change rate of amylase ≤-2.0% (Q1) vs ≥-1.9% (Q2-Q5) was 3.53 (3.00 to 4.16). The adjusted ORs were consistently significant throughout sensitivity analyses according to baseline amylase and the combination of age, body mass index, and hemoglobin A1c. CONCLUSIONS: Results showed that not low but previously decreased serum amylase was a risk factor for T2DM, suggesting the significance of periodic examinations of serum amylase values to detect individuals at high risk of T2DM.

    DOI: 10.1136/bmjdrc-2023-003482

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  • 329-OR: Accuracy of Dietary Records (DR) Using a Smartphone App Is Greatly Improved by User’s Adjustments Compared with Artificial Intelligence (AI) Alone

    MASARU KITAZAWA, CHIKA HORIKAWA, IZUMI IKEDA, YASUNAGA TAKEDA, EFREM D. FERREIRA, MIZUKI TAKEUCHI, SAKIKO Y. MORIKAWA, KAZUYA FUJIHARA, SATORU KODAMA, HIROHITO SONE

    Diabetes   72 ( Supplement_1 )   2023年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Although DR are important in managing diabetes, the traditional method, such as weighing foods and calculating nutrients, is burdensome to both patients and medical care providers. Although photo DR with smartphones using AI to identify the dish and calculate nutrients can be expected to reduce this burden, accuracy not been clarified. Furthermore, it is not clear to what extent accuracy improves when users and dietitians adjust the name of the dish and the portion consumed compared with AI only. In this study, photo DR taken with the smartphone app were analyzed by AI only, then adjusted by the users followed by further adjustments by a dietitian. We compared the nutrients calculated by AI, users, and dietitians to those by the traditional weighing method. Analyzed were 180 participants (mean age 58.7 y, BMI 26.7 kg/m2, 94/86 women/men, 22 with diabetes, energy intake [EI] 1640 kcal/day) The EIs (kcal/day) were calculated as 1502, 1619, and 1674 for AI, users, and dietitians, respectively, those were lower than that with the weighing method Spearman's rank correlation coefficients compared to the weighing method were 0.48, 0.88, and 0.88 for AI, users and dietitians, respectively, showing a weak correlation for AI and a strong correlation for users and dietitians. The user's adjustments greatly improved accuracy without increasing the burden on the dietitians.

    <p></p> Disclosure

    M.Kitazawa: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. C.Horikawa: None. I.Ikeda: None. Y.Takeda: None. E.D.Ferreira: None. M.Takeuchi: None. S.Y.Morikawa: None. K.Fujihara: None. S.Kodama: None.

    Funding

    Grants-in-Aid for Scientific Research (21K17637)

    DOI: 10.2337/db23-329-or

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  • Incidence and predictors of remission and relapse of type 2 diabetes mellitus in Japan: Analysis of a nationwide patient registry (JDDM73). 査読 国際誌

    Fujihara K, Khin L, Murai K, Yamazaki Y, Tsuruoka K, Yagyuda N, Yamazaki K, Maegawa H, Tanaka S, Kodama S, Sone H, JDDM Study Group

    Diabetes Obes Metab   25 ( 8 )   2227 - 2235   2023年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: To determine the incidence of remission and 1-year relapse from remission and associated factors in patients with type 2 diabetes. MATERIALS AND METHODS: A total of 48 320 Japanese patients with type 2 diabetes aged ≥18 years, with glycated haemoglobin (HbA1c) levels ≥48 mmol/mol (6.5%) and/or glucose-lowering drug prescription, were identified from databases of specialist clinics from 1989 and followed until September 2022. Remission was defined as HbA1c <48 mmol/mol at least 3 months after cessation of a glucose-lowering drug. Relapse was defined as failure to maintain remission for 1 year. Factors associated with remission and relapse were evaluated by logistic regression analysis. RESULTS: The overall incidence of remissions per 1000 person-years was 10.5, and for those with HbA1c levels of 48 to 53 mmol/mol (6.5% to 6.9%), those taking no glucose-lowering drugs at baseline, and those with a ≥10% body mass index (BMI) reduction in 1 year, it was 27.8, 21.7 and 48.2, respectively. Shorter duration, lower baseline HbA1c, higher baseline BMI, higher BMI reduction at 1 year, and no glucose-lowering drugs at baseline were significantly associated with remission. Among 3677 persons with remission, approximately two-thirds (2490) relapsed within 1 year. Longer duration, lower BMI at baseline, and lower BMI reduction at 1 year were significantly associated with relapse. CONCLUSIONS: The results showed that the incidence of remission and predictors of relapse, especially baseline BMI, might differ greatly between East Asian and Western populations. Furthermore, the relationships of BMI reduction with remission and relapse may be greater in East Asian than in Western populations, implying ethnic differences in returning from overt hyperglycaemia to nearly normal glucose levels.

    DOI: 10.1111/dom.15100

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  • Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia. 査読

    Kodama S, Fujihara K, Ishiguro H, Matsubayashi Y, Kitazawa M, Iwanaga M, Yamada T, Kato K, Nakagawa Y, Tanaka S, Shimano H, Sone H

    J Investig Med   2023年4月

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    記述言語:英語  

    DOI: 10.1177/10815589221149188

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  • 写真撮影とAIを活用した食事記録スマートフォンアプリによる日常の食事記録の妥当性検証

    北澤 勝, 堀川 千嘉, 長谷川 美代, 武田 安永, 治田 麻理子, 松林 泰弘, 山田 貴穂, 児玉 暁, 藤原 和哉, 曽根 博仁

    糖尿病   66 ( Suppl.1 )   S - 230   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 耐糖能や年齢で層別化した血清アミラーゼ低値およびその経時的減少が2型糖尿病発症に及ぼす影響の縦断的検討

    池田 和泉, 藤原 和哉, 大澤 妙子, 武田 安永, 治田 麻里子, 松林 泰弘, 児玉 暁, 森 保道, 本田 律子, 門脇 孝, 荒瀬 康司, 曽根 博仁

    糖尿病   66 ( Suppl.1 )   S - 215   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Utility of a Physical Fitness Score in Screening for Chronic Diseases. 国際誌

    Takaaki Sato, Kazuya Fujihara, Mayuko Harada Yamada, Kaori Chou, Yuta Yaguchi, Masaru Kitazawa, Hajime Ishiguro, Taeko Osawa, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone

    Journal of sports science & medicine   22 ( 1 )   98 - 110   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We developed a new Physical Score (PS) consisting of comprehensive physical fitness indicators and elucidated the association between the resultant PS and metabolic diseases, i.e., diabetes, hypertension, dyslipidemia, fatty liver, and metabolic syndrome (MetS), among Japanese. Analyzed were 49,850 persons (30,039 men) aged 30 to 69 y who underwent physical fitness tests. Principal component analysis was performed on the correlation matrix of the physical fitness test results (relative grip strength, single-leg balance with eyes closed, and forward bending) according to sex and age. We defined the PS as the first principal component score. A formula was developed for various age groups comprised of men and women from 30 to 69 years of age from which the PS for each age and sex was calculated. The PS for both men and women was normally distributed with a value of 0 ± 1.15-1.16. Multivariate logistic regression analysis showed that the risk of metabolic diseases increased approximately 1.1-1.6 times per each 1-point reduction in the PS. The association between PS and MetS was particularly strong in that a 1-point reduction in the PS increased the risk of MetS by 1.54 times (95% confidence interval 1.46 to 1.62) in men and by 1.21 times (1.15 to 1.28) in women. The association between a lower PS and disease risk was stronger in younger men for fatty liver and in older men for MetS. Conversely, in women, the association between a lower PS and disease risk was stronger in older women for fatty liver and in younger women for MetS. For diabetes, hypertension, and dyslipidemia, the change in the impact of PS reductions across age groups was small. The PS is a useful and simple non-invasive tool for screening Japanese people for metabolic diseases.

    DOI: 10.52082/jssm.2023.98

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  • Combined effects of blood pressure and glycemic status on risk of heart failure: a population-based study

    Ayako Kobayashi, Kazuya Fujihara, Mayuko Harada Yamada, Takaaki Sato, Yuta Yaguchi, Masaru Kitazawa, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Journal of Hypertension   Publish Ahead of Print   2023年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1097/hjh.0000000000003362

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  • Association of the estimated glomerular filtration rate (eGFR) and/or proteinuria to predict the risk of initiation of dialysis in people with and without diabetes.

    Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Yuta Yaguchi, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Diabetology international   14 ( 1 )   86 - 93   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: To determine the associations between combined urinary protein (UP) and a reduced estimated glomerular filtration rate (eGFR) and the risk of starting dialysis with or without diabetes mellitus (DM). METHODS: A nationwide database with claims data on 335,778 people with and without DM aged 19-72 years in Japan was used to elucidate the impact of the severities of UP and eGFR on starting dialysis. Initiation of dialysis was determined from claims using ICD-10 codes and medical procedures. Using multivariate Cox modeling, we investigated the severities of UP and eGFR to predict the initiation of dialysis with and without DM. RESULTS: Both eGFR < 60 and UP(+) were independent predictors for starting dialysis with and without DM, and their values exhibited a synergistic risk of dialysis. eGFR < 60 presented a nearly twofold risk for starting dialysis compared to UP(+) regardless of DM. Risk of starting dialysis was increased with UP(+) and eGFR ≥ 60 accompanied by DM although this association was not observed without DM. Those who had UP(-) and eGFR < 60 had a high risk of starting dialysis regardless of DM. Compared with DM(-)UP(-)eGFR ≥ 60, HRs for starting dialysis for DM(+)UP(+)eGFR ≥ 60, DM(+)UP(-)eGFR < 60 and DM(+)UP(+)eGFR < 60 significantly increased 17.7 (10.6-29.7), 25.5 (13.8-47.1) and 358.1 (239.1-536.5) times, respectively. CONCLUSIONS: eGFR < 60 and UP(+) together presented an extremely high risk of dialysis especially with DM. UP( +) increased the risk of starting dialysis regardless of the eGFR with DM. Both patient education and a treatment strategy by physicians might be helpful to avoid the progression of renal failure.

    DOI: 10.1007/s13340-022-00603-z

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  • Machine learning approach to predict body weight in adults. 国際誌

    Kazuya Fujihara, Mayuko Yamada Harada, Chika Horikawa, Midori Iwanaga, Hirofumi Tanaka, Hitoshi Nomura, Yasuharu Sui, Kyouhei Tanabe, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone

    Frontiers in public health   11   1090146 - 1090146   2023年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Obesity is an established risk factor for non-communicable diseases such as type 2 diabetes mellitus, hypertension and cardiovascular disease. Thus, weight control is a key factor in the prevention of non-communicable diseases. A simple and quick method to predict weight change over a few years could be helpful for weight management in clinical settings. METHODS: We examined the ability of a machine learning model that we constructed to predict changes in future body weight over 3 years using big data. Input in the machine learning model were three-year data on 50,000 Japanese persons (32,977 men) aged 19-91 years who underwent annual health examinations. The predictive formulas that used heterogeneous mixture learning technology (HMLT) to predict body weight in the subsequent 3 years were validated for 5,000 persons. The root mean square error (RMSE) was used to evaluate accuracy compared with multiple regression. RESULTS: The machine learning model utilizing HMLT automatically generated five predictive formulas. The influence of lifestyle on body weight was found to be large in people with a high body mass index (BMI) at baseline (BMI ≥29.93 kg/m2) and in young people (<24 years) with a low BMI (BMI <23.44 kg/m2). The RMSE was 1.914 in the validation set which reflects ability comparable to that of the multiple regression model of 1.890 (p = 0.323). CONCLUSION: The HMLT-based machine learning model could successfully predict weight change over 3 years. Our model could automatically identify groups whose lifestyle profoundly impacted weight loss and factors the influenced body weight change in individuals. Although this model must be validated in other populations, including other ethnic groups, before being widely implemented in global clinical settings, results suggested that this machine learning model could contribute to individualized weight management.

    DOI: 10.3389/fpubh.2023.1090146

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  • 耐糖能およびHDL-C値によるLDL-C値が冠動脈疾患発症に及ぼす影響の検討

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病合併症   36 ( Suppl.1 )   173 - 173   2022年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • Fast walking and physical activity are independent contributors to improved physical function. 国際誌

    Haruka Shiozaki, Kazuya Fujihara, Mayuko Yamada-Harada, Masahiko Yamamoto, Yurie Mitsuma, Masaru Kitazawa, Yuta Yaguchi, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Family practice   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND OBJECTIVES: To clarify whether the presence or absence of fast walking and habitual physical activity are independently associated with the incidence of functional disability. METHODS: This historical cohort study was comprised of 9,652 (4,412 men, mean age 65 years) individuals aged 39-98 years without functional disability at baseline. Functional disability was determined based on the Japanese long-term care insurance system, which specified requirements for assistance in the activities of daily living. The impact of fast walking and habitual physical activity on the incidence of functional disability was analysed by Cox proportional hazards models. RESULTS: The follow-up period was a median of 3.7 years during which 165 patients were newly certified as having functional disability. In the multivariate analysis, baseline age in 5-year increments (hazard ratio 2.42 [95% confidence interval 2.18-2.69]), no habitual physical activity (1.56 [1.07-2.27]), and not fast walking (1.89 [1.32-2.69]) significantly increased the risk of functional disability after adjustment for covariates. The stratified analysis showed that compared with physical activity (+), the impact of physical activity (-) on the incidence of functional disability was observed in those aged ≥75 years regardless of fast walking (+). Fast walking (-) significantly increased the risk of disability compared with fast walking (+) in those aged <75 years regardless of a physical activity habit. CONCLUSION: In Japanese, slow walking speed and lack of a physical activity habit were shown to be independent risk factors for incident functional disability, with their impact differing according to age.

    DOI: 10.1093/fampra/cmac087

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  • 生活習慣・栄養分野におけるガイドライン2022のトピックスと今後の課題 脂質改善・動脈硬化予防のための運動・身体活動

    木庭 新治, 曽根 博仁, 児玉 暁, 藤原 和哉, 横田 裕哉, 宮下 政司, 井上 茂

    日本動脈硬化学会総会プログラム・抄録集   54回   151 - 151   2022年7月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex. 国際誌

    Yasuhiro Matsubayashi, Kazuya Fujihara, Mayuko Yamada-Harada, Yurie Mitsuma, Takaaki Sato, Yuta Yaguchi, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Cardiovascular diabetology   21 ( 1 )   90 - 90   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: To determine the impact of metabolic syndrome (MetS) and/or metabolic dysfunction-associated fatty liver disease (MAFLD), which are pathophysiologically similar and include insulin resistance, on the development of new-onset cardiovascular disease with and without type 2 diabetes and according to sex. METHODS: This study included 570,426 individuals without a history of cardiovascular disease who were enrolled in a nationwide claims database from 2008 to 2016 and were classified by the presence or absence of MetS and/or MAFLD stratified by the presence or absence of type 2 diabetes and sex. The fatty liver index was used to determine the presence or absence of fatty liver that required a diagnosis of MAFLD. Risks of developing coronary artery disease (CAD) and cerebrovascular disease (CVD) in each category were analyzed using a multivariate Cox proportional hazard model. RESULTS: During a median follow-up of 5.2 years, 2252 CAD and 3128 CVD events occurred. Without type 2 diabetes the hazard ratio (HR) (95% CI) for CAD/CVD compared with neither MAFLD nor MetS was 1.32 (1.17-1.50)/1.41(1.28-1.57) for MAFLD only (without MetS), 1.78 (1.22-2.58)/1.66 (1.34-2.06) for MetS only (without MAFLD), and 2.10 (1.84-2.39)/1.73 (1.54-1.95) for MAFLD + MetS. For those with type 2 diabetes, the HR for CAD for MAFLD only (compared with neither MAFLD nor MetS) was 1.29 (1.06-1.58), for MetS only 1.34 (0.84-2.13), and for MAFLD + MetS 1.22 (1.02-1.47). For CVD, there was a significant increase in HR only in MAFLD + MetS [1.44 (1.18-1.76)]. The results of the analysis stratified by sex showed that MAFLD had a greater impact in men, and MetS had a greater impact in women regarding the development of CAD. CONCLUSIONS: Distinguishing between MetS and/or MAFLD in the presence or absence of type 2 diabetes and according to sex may aid in accurately identifying patients at high risk of cardiovascular disease.

    DOI: 10.1186/s12933-022-01518-4

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  • 肥満における各野菜摂取頻度と遺伝子・環境相互作用の検討

    藤原 和哉, 野川 駿, 齋藤 憲司, 堀川 千嘉, 武田 安永, 張 かおり, 石黒 創, 児玉 暁, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 160   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 耐糖能およびHDLコレステロール値別にみたLDLコレステロールが冠動脈疾患に及ぼす影響の検討

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴徳, 児玉 暁, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 186   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • HDLコレステロール値別にみたLDLコレステロールと冠動脈疾患との関連

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴穂, 児玉 暁, 曽根 博仁

    日本内分泌学会雑誌   98 ( 1 )   322 - 322   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 妊娠中期における母体のインスリン値と低出生体重児出産との関連の検討

    谷内 洋子, 藤原 和哉, 堀川 千嘉, 生魚 薫, 山本 正彦, 石澤 正博, 山田 貴穂, 児玉 暁, 曽根 博仁

    Journal of Epidemiology   32 ( Suppl.1 )   142 - 142   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 耐糖能別おける収縮期血圧と冠動脈疾患(CAD)/脳血管疾患発症(CVD)の関連

    藤原 和哉, 山田 万祐子, 山本 正彦, 松林 泰弘, 北澤 勝, 石澤 正博, 堀川 千嘉, 児玉 暁, 曽根 博仁

    Journal of Epidemiology   32 ( Suppl.1 )   128 - 128   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta-analysis.

    Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Masaru Kitazawa, Midori Iwanaga, Kiminori Kato, Kenichi Watanabe, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Hirohito Sone

    Journal of diabetes investigation   13 ( 5 )   900 - 908   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS/INTRODUCTION: Recently, an increasing number of cohort studies have suggested using machine learning (ML) to predict type 2 diabetes mellitus. However, its predictive ability remains inconclusive. This meta-analysis evaluated the current ability of ML algorithms for predicting incident type 2 diabetes mellitus. MATERIALS AND METHODS: We systematically searched longitudinal studies published from 1 January 1950 to 17 May 2020 using MEDLINE and EMBASE. Included studies had to compare ML's classification with the actual incidence of type 2 diabetes mellitus, and present data on the number of true positives, false positives, true negatives and false negatives. The dataset for these four values was pooled with a hierarchical summary receiver operating characteristic and a bivariate random effects model. RESULTS: There were 12 eligible studies. The pooled sensitivity, specificity, positive likelihood ratio and negative likelihood ratio were 0.81 (95% confidence interval [CI] 0.67-0.90), 0.82 [95% CI 0.74-0.88], 4.55 [95% CI 3.07-6.75] and 0.23 [95% CI 0.13-0.42], respectively. The area under the summarized receiver operating characteristic curve was 0.88 (95% CI 0.85-0.91). CONCLUSIONS: Current ML algorithms have sufficient ability to help clinicians determine whether individuals will develop type 2 diabetes mellitus in the future. However, persons should be cautious before changing their attitude toward future diabetes risk after learning the result of the diabetes prediction test using ML algorithms.

    DOI: 10.1111/jdi.13736

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  • Impact of Medication Adherence and Glycemic Control on the Risk of Micro- and Macrovascular Diseases in Patients with Diabetes. 国際誌

    Yuta Yaguchi, Kazuya Fujihara, Mayuko Harada Yamada, Yasuhiro Matsubayashi, Takaho Yamada, Midori Iwanaga, Masaru Kitazawa, Masahiko Yamamoto, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

    The American journal of medicine   135 ( 4 )   461 - 470   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Our purpose in the research was to clarify the impact of medication adherence to oral hypoglycemic agents during a 1-year period and subsequent glycemic control on the risk of micro- and macrovascular diseases. METHODS: Examined was a nationwide claims database on 13,256 individuals with diabetic eye disease without requiring prior treatment, 7,862 without prior initiation of dialysis, 15,556 without prior coronary artery disease, 16,243 without prior cerebrovascular disease, and 19,386 without prior heart failure from 2008 to 2016 in Japan. Medication adherence was evaluated by the proportion of days covered. Patients were considered to have poor adherence if the proportion of days covered was <80%. Multivariate Cox regression model identified risks of micro- and macrovascular diseases. RESULTS: In each group, mean age was 53 to 54 years, HbA1c was 7.1% to 7.2%, and median follow-up period was 4.6 to 5.1 years, and the percentage of poor adherence was approximately 30%. During the study period, 532 treatment-requiring diabetic eye disease, 75 dialysis, 389 coronary artery disease, 316 cerebrovascular disease, and 144 heart failure events occurred. Multivariate Cox regression model revealed that the hazard ratio (95% confidence interval) of dialysis in the poor adherence group was 2.04 (1.27-3.30) compared with the good adherence group. The hazard ratios in the poor adherence/poor glycemic control group were 3.34 (2.63-4.24) for treatment-requiring diabetic eye disease, 4.23 (2.17-8.26) for dialysis, 1.69 (1.23-2.31) for coronary artery disease, and 2.08 (1.25-3.48) for heart failure compared with the good adherence/good glycemic control group. CONCLUSIONS: Poor medication adherence was an independent risk factor for the initiation of dialysis, suggesting that clinicians must pay close attention to these patients.

    DOI: 10.1016/j.amjmed.2021.10.018

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  • Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711. 国際誌

    Kazuya Fujihara, Shun Nogawa, Kenji Saito, Chika Horikawa, Yasunaga Takeda, Kaori Cho, Hajime Ishiguro, Satoru Kodama, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Hirohito Sone

    Nutrients   13 ( 10 )   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It is unclear whether genetic interactions are involved in the association between vegetable intake and reduced body mass index (BMI) or obesity. We conducted a comprehensive search for single nucleotide polymorphisms (SNPs) which are associated with the interaction between vegetable intake frequency and BMI or obesity. We performed a genome-wide association analysis to evaluate the genetic interactions between self-reported intake of vegetables such as carrot, broccoli, spinach, other green vegetables (green pepper and green beans), pumpkin, and cabbage with BMI and obesity, which is defined as a BMI ≥ 25.0 kg/m2 in the Japanese population (n = 12,225). The mean BMI and prevalence of obesity was 23.9 ± 3.4 kg/m2 and 32.3% in men and 22.1 ± 3.8 kg/m2 and 17.3% in in women, respectively. A significant interaction was observed between rs4445711 and frequency of carrot intake on BMI (p = 4.5 × 10-8). This interaction was slightly attenuated after adjustment for age, sex, alcohol intake, smoking, physical activity and the frequency of total vegetable intake (p = 2.1 × 10-7). A significant interaction was also observed between rs4445711 and frequency of carrot intake on obesity (p = 2.5 × 10-8). No significant interactions that were the same as the interaction between frequency of carrot intake and rs4445711 were observed between the intake frequency of broccoli, spinach, other green vegetables, pumpkin or cabbage and BMI or obesity. The frequency of carrot consumption is implicated in reducing BMI by the intermediary of rs4445711. This novel genetic association may provide new clues to clarify the association between vegetable intake and BMI or obesity.

    DOI: 10.3390/nu13103478

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  • 経口血糖降下薬(OHA)の服薬アドヒアランスおよび血糖コントロールと細小/大血管合併症発症の関連の検討

    矢口 雄大, 藤原 和哉, 山田 万祐子, 北澤 勝, 山本 正彦, 岩永 みどり, 山田 貴穂, 清田 浩康, 松林 泰弘, 児玉 暁, 曽根 博仁

    糖尿病合併症   35 ( Suppl. )   173 - 173   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 血清尿酸値と重症糖尿病網膜症との関係

    山本 正彦, 藤原 和哉, 矢口 雄大, 大澤 妙子, 山田 万祐子, 松林 泰弘, 長谷部 日, 山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病合併症   35 ( Suppl. )   268 - 268   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure 査読 国際誌

    Kodama S, Horikawa C, Fujihara K, Hatta M, Takeda Y, Nedachi R, Kato K, Watanabe K, Sone H

    Hypertenion Research   44 ( 7 )   885 - 887   2021年7月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41440-021-00632-2

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  • Author Correction: Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure. 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Mariko Hatta, Yasunaga Takeda, Rena Nedachi, Kiminori Kato, Kenichi Watanabe, Hirohito Sone

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 7 )   894 - 894   2021年7月

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  • Associations of Systolic Blood Pressure and Diastolic Blood Pressure With the Incidence of Coronary Artery Disease or Cerebrovascular Disease According to Glucose Status

    Mayuko Harada Yamada, Kazuya Fujihara, Satoru Kodama, Takaaki Sato, Taeko Osawa, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Wataru Ogawa, Hirohito Sone

    Diabetes Care   dc202252 - dc202252   2021年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    DOI: 10.2337/dc20-2252

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  • Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database. 国際誌

    Masanori Kaneko, Kazuya Fujihara, Mayuko Yamada Harada, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

    Journal of foot and ankle research   14 ( 1 )   29 - 29   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The prevalence of diabetes is rising, and diabetes develops at a younger age in East Asia. Although lower limb amputation negatively affects quality of life and increases the risk of cardiovascular events, little is known about the rates and predictors of amputation among persons with diabetes from young adults to those in the "young-old" category (50-72 y). METHODS: We analyzed data from a nationwide claims database in Japan accumulated from 2008 to 2016 involving 17,288 people with diabetes aged 18-72 y (mean age 50.2 y, HbA1c 7.2%). Amputation occurrence was determined according to information from the claims database. Cox regression model identified variables related to lower limb amputation. RESULTS: The mean follow-up time was 5.3 years, during which time 16 amputations occurred (0.17/1000 person-years). Multivariate Cox regression analysis showed that age (hazard ratio [HR] 1.09 [95% confidence intervals] 1.02-1.16, p = 0.01) and HbA1c (HR 1.46 [1.17-1.81], p < 0.01) were independently associated with amputations. Compared with those aged < 60 years with HbA1c < 8.0%, the HR for amputation was 27.81 (6.54-118.23) in those aged ≥60 years and HbA1c ≥8.0%. CONCLUSIONS: Age and HbA1c were associated with amputations among diabetic individuals, and the rates of amputation were significantly greater in those ≥60 years old and with HbA1c ≥8.0%.

    DOI: 10.1186/s13047-021-00474-8

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  • Accuracy of Japanese claims data in identifying diabetes‐related complications

    Kazuya Fujihara, Mayuko Yamada‐Harada, Yasuhiro Matsubayashi, Masaru Kitazawa, Masahiko Yamamoto, Yuta Yaguchi, Hiroyasu Seida, Satoru Kodama, Kohei Akazawa, Hirohito Sone

    Pharmacoepidemiology and Drug Safety   2021年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/pds.5213

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  • Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus. 国際誌

    Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Hiroyasu Seida, Satoru Kodama, Yoshimi Nakagawa, Hitoshi Shimano, Hirohito Sone

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research   69 ( 3 )   724 - 729   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To determine associations between severity of hypertension and risk of starting dialysis in the presence or absence of diabetes mellitus (DM). A nationwide database with claims data on 258 874 people with and without DM aged 19-72 years in Japan was used to elucidate the impact of severity of hypertension on starting dialysis. Initiation of dialysis was determined from claims using International Classification of Diseases-10 codes and medical procedures. Using multivariate Cox modeling, we investigated the severity of hypertension to predict the initiation of dialysis with and without DM. Hypertension was significantly associated with the initiation of dialysis regardless of DM. The incidence of starting dialysis in those with systolic blood pressure (SBP) ≤119 mm Hg and DM (DM+) was almost the same as in those with SBP ≥150 mm Hg and absence of DM (DM-). In comparison with SBP ≤119 mm Hg, SBP ≥150 mm Hg significantly increased the risk of the initiation of dialysis about 2.5 times regardless of DM+ or DM-. Compared with DM- and SBP ≤119 mm Hg, the HR for DM+ and SBP ≥150 mm Hg was 6.88 (95% CI 3.66 to 12.9). Although the risks of hypertension differed only slightly regardless of the presence or absence of DM, risks for starting dialysis with DM+ and SBP ≤119 mm Hg were equivalent to DM- and SBP ≥150 mm Hg, indicating more strict blood pressure interventions in DM+ are needed to avoid dialysis. Future studies are required to clarify the cut-off SBP level to avoid initiation of dialysis considering the risks of strict control of blood pressure.

    DOI: 10.1136/jim-2020-001489

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  • メタ解析的アプローチによる塩分摂取と心不全発症リスクとの量-反応分析

    児玉 暁, 藤原 和哉, 渡辺 賢一, 加藤 公則, 曽根 博仁

    日本内科学会雑誌   110 ( Suppl. )   142 - 142   2021年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • Ability of Current Machine Learning Algorithms to Predict and Detect Hypoglycemia in Patients With Diabetes Mellitus: Meta-analysis. 国際誌

    Satoru Kodama, Kazuya Fujihara, Haruka Shiozaki, Chika Horikawa, Mayuko Harada Yamada, Takaaki Sato, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Midori Iwanaga, Yasuhiro Matsubayashi, Hirohito Sone

    JMIR diabetes   6 ( 1 )   e22458   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Machine learning (ML) algorithms have been widely introduced to diabetes research including those for the identification of hypoglycemia. OBJECTIVE: The objective of this meta-analysis is to assess the current ability of ML algorithms to detect hypoglycemia (ie, alert to hypoglycemia coinciding with its symptoms) or predict hypoglycemia (ie, alert to hypoglycemia before its symptoms have occurred). METHODS: Electronic literature searches (from January 1, 1950, to September 14, 2020) were conducted using the Dialog platform that covers 96 databases of peer-reviewed literature. Included studies had to train the ML algorithm in order to build a model to detect or predict hypoglycemia and test its performance. The set of 2 × 2 data (ie, number of true positives, false positives, true negatives, and false negatives) was pooled with a hierarchical summary receiver operating characteristic model. RESULTS: A total of 33 studies (14 studies for detecting hypoglycemia and 19 studies for predicting hypoglycemia) were eligible. For detection of hypoglycemia, pooled estimates (95% CI) of sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were 0.79 (0.75-0.83), 0.80 (0.64-0.91), 8.05 (4.79-13.51), and 0.18 (0.12-0.27), respectively. For prediction of hypoglycemia, pooled estimates (95% CI) were 0.80 (0.72-0.86) for sensitivity, 0.92 (0.87-0.96) for specificity, 10.42 (5.82-18.65) for PLR, and 0.22 (0.15-0.31) for NLR. CONCLUSIONS: Current ML algorithms have insufficient ability to detect ongoing hypoglycemia and considerate ability to predict impeding hypoglycemia in patients with diabetes mellitus using hypoglycemic drugs with regard to diagnostic tests in accordance with the Users' Guide to Medical Literature (PLR should be ≥5 and NLR should be ≤0.2 for moderate reliability). However, it should be emphasized that the clinical applicability of these ML algorithms should be evaluated according to patients' risk profiles such as for hypoglycemia and its associated complications (eg, arrhythmia, neuroglycopenia) as well as the average ability of the ML algorithms. Continued research is required to develop more accurate ML algorithms than those that currently exist and to enhance the feasibility of applying ML in clinical settings. TRIAL REGISTRATION: PROSPERO International Prospective Register of Systematic Reviews CRD42020163682; http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42020163682.

    DOI: 10.2196/22458

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  • Machine Learning Approach to Decision Making for Insulin Initiation in Japanese Patients With Type 2 Diabetes (JDDM 58): Model Development and Validation Study. 国際誌

    Kazuya Fujihara, Yasuhiro Matsubayashi, Mayuko Harada Yamada, Masahiko Yamamoto, Toshihiro Iizuka, Kosuke Miyamura, Yoshinori Hasegawa, Hiroshi Maegawa, Satoru Kodama, Tatsuya Yamazaki, Hirohito Sone

    JMIR medical informatics   9 ( 1 )   e22148   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Applications of machine learning for the early detection of diseases for which a clear-cut diagnostic gold standard exists have been evaluated. However, little is known about the usefulness of machine learning approaches in the decision-making process for decisions such as insulin initiation by diabetes specialists for which no absolute standards exist in clinical settings. OBJECTIVE: The objectives of this study were to examine the ability of machine learning models to predict insulin initiation by specialists and whether the machine learning approach could support decision making by general physicians for insulin initiation in patients with type 2 diabetes. METHODS: Data from patients prescribed hypoglycemic agents from December 2009 to March 2015 were extracted from diabetes specialists' registries, resulting in a sample size of 4860 patients who had received initial monotherapy with either insulin (n=293) or noninsulin (n=4567). Neural network output was insulin initiation ranging from 0 to 1 with a cutoff of >0.5 for the dichotomous classification. Accuracy, recall, and area under the receiver operating characteristic curve (AUC) were calculated to compare the ability of machine learning models to make decisions regarding insulin initiation to the decision-making ability of logistic regression and general physicians. By comparing the decision-making ability of machine learning and logistic regression to that of general physicians, 7 cases were chosen based on patient information as the gold standard based on the agreement of 8 of the 9 specialists. RESULTS: The AUCs, accuracy, and recall of logistic regression were higher than those of machine learning (AUCs of 0.89-0.90 for logistic regression versus 0.67-0.74 for machine learning). When the examination was limited to cases receiving insulin, discrimination by machine learning was similar to that of logistic regression analysis (recall of 0.05-0.68 for logistic regression versus 0.11-0.52 for machine learning). Accuracies of logistic regression, a machine learning model (downsampling ratio of 1:8), and general physicians were 0.80, 0.70, and 0.66, respectively, for 43 randomly selected cases. For the 7 gold standard cases, the accuracies of logistic regression and the machine learning model were 1.00 and 0.86, respectively, with a downsampling ratio of 1:8, which were higher than the accuracy of general physicians (ie, 0.43). CONCLUSIONS: Although we found no superior performance of machine learning over logistic regression, machine learning had higher accuracy in prediction of insulin initiation than general physicians, defined by diabetes specialists' choice of the gold standard. Further study is needed before the use of machine learning-based decision support systems for insulin initiation can be incorporated into clinical practice.

    DOI: 10.2196/22148

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  • Network Meta-Analysis of Drug Therapies for Lowering Uric Acid and Mortality Risk in Patients with Heart Failure. 国際誌

    Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Mayuko Yamada, Takaaki Sato, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Kenichi Watanabe, Hirohito Sone

    Cardiovascular drugs and therapy   35 ( 6 )   1217 - 1225   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: This network meta-analysis aimed to assess the current efficacy of decreasing the uric acid (UA) level with drugs to reduce mortality in patients with heart failure (HF). METHODS: Electronic literature searches using EMBASE and MEDLINE of studies published from 1 Jan 1950 to 26 Dec 2019 were conducted for randomized controlled trials or non-randomized cohort studies that included at least one group of patients who took UA-lowering drugs and with a study outcome of all-cause mortality. A random-effects network meta-analysis was performed within a frequentist framework. Hierarchy of treatments was expressed as the surface under the cumulative ranking curve (SUCRA) value, which is in proportion to mean rank (best is 100%). RESULTS: Nine studies, which included seven different types of groups, were eligible for analysis. The "untreated uricemia" group in which patients had hyperuricemia but without treatment had a significantly higher risk of mortality than the "no uricemia" group in which patients had no hyperuricemia (relative risk (RR)(95% confidence interval (CI), 1.43 (1.08-1.89)). The "start-allo" group wherein patients started to take allopurinol did not have a significantly lower risk of mortality than the "untreated uricemia" group (RR (95% CI), 0.68 (0.45-1.01)). However, in the "start-allo" group the SUCRA value was comparable to that in the "no uricemia" group (SUCRA: 65.4% for "start-allo"; 64.1% for "no uricemia"). CONCLUSIONS: Results suggested that allopurinol therapy was not associated with a significantly improved prognosis in terms of mortality but could potentially counteract the adverse effects associated with longstanding hyperuricemia in HF patients.

    DOI: 10.1007/s10557-020-07097-4

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  • Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis. 査読 国際誌

    Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Takaaki Sato, Midori Iwanaga, Takaho Yamada, Kiminori Kato, Kenichi Watanabe, Hitoshi Shimano, Tohru Izumi, Hirohito Sone

    ESC heart failure   7 ( 5 )   2146 - 2174   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Despite mounting evidence of the positive relationship between diabetes mellitus (DM) and heart failure (HF), the entire context of the magnitude of risk for HF in relation to DM remains insufficiently understood. The principal reason is because new-onset HF (HF occurring in participants without a history of HF) and recurrent HF (HF re-occurring in patients with a history of HF) are not discriminated. This meta-analysis aims to comprehensively and separately assess the risk of new-onset and recurrent HF depending on the presence or absence of DM. We systematically searched cohort studies that examined the relationship between DM and new-onset or recurrent HF using EMBASE and MEDLINE (from 1 Jan 1950 to 28 Jul 2019). The risk ratio (RR) for HF in individuals with DM compared with those without DM was pooled with a random-effects model. Seventy-four and 38 eligible studies presented data on RRs for new-onset and recurrent HF, respectively. For new-onset HF, the pooled RR [95% confidence interval (CI)] of 69 studies that examined HF as a whole [i.e. combining HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF)] was 2.14 (1.96-2.34). The large between-study heterogeneity (I2 = 99.7%, P < 0.001) was significantly explained by mean age [pooled RR (95% CI) 2.60 (2.38-2.84) for mean age < 60 years vs. pooled RR (95% CI) 1.95 (1.79-2.13) for mean age ≥ 60 years] (P < 0.001). Pooled RRs (95% CI) of seven and eight studies, respectively, that separately examined HFpEF and HFrEF risk were 2.22 (2.02-2.43) for HFpEF and 2.73 (2.71-2.75) for HFrEF. The risk magnitudes between HFpEF and HFrEF were not significantly different in studies that examined both HFpEF and HFrEF risks (P = 0.86). For recurrent HF, pooled RR (95% CI) of the 38 studies was 1.39 (1.33-1.45). The large between-study heterogeneity (I2 = 80.1%, P < 0.001) was significantly explained by the proportion of men [pooled RR (95% CI) 1.53 (1.40-1.68) for < 65% men vs. 1.32 (1.25-1.39) for ≥65% men (P = 0.01)] or the large pooled RR for studies of only participants with HFpEF [pooled RR (95% CI), 1.73 (1.32-2.26) (P = 0.002)]. Results indicate that DM is a significant risk factor for both new-onset and recurrent HF. It is suggested that the risk magnitude is large for new-onset HF especially in young populations and for recurrent HF especially in women or individuals with HFpEF. DM is associated with future HFpEF and HFrEF to the same extent.

    DOI: 10.1002/ehf2.12782

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  • 糖尿病の有無別にみた日本人男性におけるBMI・腹囲と冠動脈疾患発症との関連

    上村 和樹, 藤原 和哉, 山田 万祐子, 北澤 勝, 矢口 雄大, 清田 浩康, 山中 菜詩, 松林 泰弘, 山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 229   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice. 国際誌

    Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst Rejina Afrin, Remya Sreedhar, Meilei Harima, Masahiko Nakamura, Kenichi Watanabe, Satoru Kodama, Kazuya Fujihara, Hirohito Sone

    Neurochemistry international   137   104745 - 104745   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM AND OBJECTIVE: Insulin-induced moderate or severe hypoglycemia (MH or SH) impairs cognition and SH causes neuronal death. On the contrary, alternate day fasting (ADF) protects the brain during excitotoxic stress and improves cognitive function. Unlike the scenario in the periphery, insulin and its relationship towards brain glucose uptake and metabolism are considered to be less significant. Yet, the hypoglycemia associated brain metabolism is not clearly understood. The authors broadly investigated the brain metabolism in various hypoglycemic models such as insulin-induced MH, SH, SH with glucose reperfusion, 24 h fasting and ADF in the cortex or hippocampus of C57BL6/J mice. The authors analyzed the protein expression of insulin signaling kinases (plays a key role in neuronal survival and memory), Bcl-2 associated death promoter (p-BADser155) (dephosphorylation inhibits glucokinase activity and reduces glucose or increases ketone body metabolism in the brain), neuronal-specific glucose transporter 3 (GLUT 3) and nitrotyrosine (marker of nitric oxide which is involved in neuronal glucose uptake via GLUT 3) using western blotting analysis. RESULTS: Insulin-induced MH or SH differentially regulated the brain insulin signaling kinases. The expression of p-BADser155 decreased in all hypoglycemic models except the insulin-induced MH in hippocampus. The trended higher GLUT 3 and increased nitrotyrosine expression of insulin-induced SH were restored after glucose reperfusion. The trended higher or increased GLUT 3 and nitrotyrosine expression of ADF were positively correlated with serum beta-hydroxybutyrate levels. CONCLUSION: During hypoglycemia, it can be suggested that the brain might decrease glucose metabolism via glycolysis or prefer ketone body metabolism (except the insulin-induced MH in hippocampus) by modifying the p-BADser155 expression. In addition to the ketone body metabolism, the brain might adapt to uptake glucose in insulin-induced SH or ADF by modifying the GLUT 3 or nitrotyrosine expression.

    DOI: 10.1016/j.neuint.2020.104745

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  • 心不全患者に対する高尿酸血症治療薬の予後改善効果に関するネットワークメタ分析

    児玉 暁, 藤原 和哉, 渡辺 賢一, 加藤 公則, 曽根 博仁

    日本動脈硬化学会総会プログラム・抄録集   52回   234 - 234   2020年7月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • Skipping breakfast, late-night eating and current smoking are associated with medication adherence in Japanese patients with diabetes. 査読 国際誌

    Yuta Yaguchi, Kazuya Fujihara, Mayuko Harada Yamada, Yasuhiro Matsubayashi, Masaru Kitazawa, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Nauta Yamanaka, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

    Primary care diabetes   14 ( 6 )   753 - 759   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Little is known about the relationship between medication adherence for oral hypoglycemic agents (OHAs) and glycemic control after adjusting healthy adherer effect in large scale study. Thus, adjusting for health-related behaviors, we investigated the clinical variables associated with medication adherence and the relationship between medication adherence and glycemic control using a large claims database. METHODS: Analyzed were 8805 patients with diabetes whose medication records for OHA were available for at least 1year. Medication adherence was evaluated by the proportion of days covered (PDC). Multivariate logistic regression model was used to identify clinical variables significantly associated with non-adherence. Multiple regression analysis evaluated the relationship between PDC and HbA1c after adjusting for health-related behaviors. RESULTS: Mean PDC was 80.1% and 32.8% of patients were non-adherence. Logistic analysis indicated that older age and taking concomitant medications were significantly associated with adherence while skipping breakfast (odds ratio 0.66 [95% CI 0.57-0.76]), late-night eating (0.86 [0.75-0.98]), and current smoking (0.89 [0.80-0.99]) were significantly associated with non-adherence. CONCLUSIONS: Skipping breakfast, late-night eating and current smoking were significantly associated with medication adherence, suggesting that clinicians pay attention to those health-related behaviors to achieve good medication adherence.

    DOI: 10.1016/j.pcd.2020.05.002

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  • Combination of diabetes mellitus and lack of habitual physical activity is a risk factor for functional disability in Japanese. 査読 国際誌

    Kazuya Fujihara, Yasuhiro Matsubayashi, Mayuko Harada Yamada, Masaru Kitazawa, Masahiko Yamamoto, Masanori Kaneko, Satoru Kodama, Takuya Yahiro, Ayumu Tsutsui, Kiminori Kato, Hirohito Sone

    BMJ open diabetes research & care   8 ( 1 )   2020年1月

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    記述言語:英語  

    OBJECTIVE: Declining healthy life expectancy due to functional disability is relevant and urgent because of its association with decreased quality of life and also for its enormous socioeconomic impact. The aim of this study is to examine the impact of diabetes, hypertension, dyslipidemia and physical activity habits on functional disability among community-dwelling Japanese adults. RESEARCH DESIGN AND METHODS: This is a population-based retrospective cohort study including 9673 people aged 39-98 years in Japan (4420, men). Functional disability was defined as a condition meeting Japan's new long-term care insurance certification requirements for the need of assistance in the activities of daily living whether by caregivers or assistive devices. Cox proportional-hazards regression model identified variables related to functional disability. RESULTS: Median follow-up was 3.7 years. During the study period, 165 disabilities occurred in the overall study population. Multivariate analysis showed that diabetes (HR 1.74 (95% CI 1.12 to 2.68)) and no physical activity habit (HR 1.83 (1.27 to 2.65)) presented increased risks for disability. HR for disability increased with the number of risk factors (HR of individuals with four conditions, 3.96 (1.59 to 9.99) vs individuals with none of those conditions as a reference). HR for disability among patients with diabetes with and without a physical activity habit was 1.68 (0.70 to 4.04) and 3.19 (1.79 to 5.70), respectively, compared with individuals without diabetes with a physical activity habit. CONCLUSIONS: The combination of diabetes and lack of habitual physical activity is predictive of functional disability in Japanese. Habitual physical activity attenuates the risk of functional disability in patients with diabetes.

    DOI: 10.1136/bmjdrc-2019-000901

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  • Physical Fitness and Dyslipidemia Among Japanese: A Cohort Study From the Niigata Wellness Study

    Haruki Momma, Kiminori Kato, Susumu S. Sawada, Yuko Gando, Ryoko Kawakami, Motohiko Miyachi, Ryoichi Nagatomi, Minoru Tashiro, Yasuhiro Matsubayashi, Satoru Kodama, Midori Iwanaga, Kazuya Fujihara, Hirohito Sone

    Journal of Epidemiology   2020年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Epidemiological Association  

    DOI: 10.2188/jea.je20200034

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  • Predictive Ability of Incident Type 2 Diabetes Mellitus (T2DM) Using Machine Learning Algorithms: A Meta-analysis

    Kodama, Satoru, Sato, Takaaki, Yamamoto, Masahiko, Ishiguro, Hajime, Iwanaga, Midori, Fujihara, Kazuya, Yamada, Takaho, Kato, Kiminori, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-841-P

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  • Low Level of and Decrease in Serum Amylase (AMY) Increases the Risk of Type 2 Diabetes Mellitus (T2DM)

    Ikeda, Izumi, Fujihara, Kazuya, Risa, Igarashi, Yamada, Mayuko H., Nedachi, Rina, Hatta, Mariko, Kodama, Satoru, Mori, Yasumichi, Matsubayashi, Yasuhiro, Arase, Yasuji, Sone, Hirohito, Yamamoto-Honda, Ritsuko

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-1903-P

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  • Ability for Detecting or Predicting Hypoglycemia with the Aid of Machine Learning Techniques: A Meta-analysis

    Kodama, Satoru, Yamada, Mayuko H., Yaguchi, Yuta, Kitazawa, Masaru, Kaneko, Masanori, Matsubayashi, Yasuhiro, Fujihara, Kazuya, Iwanaga, Midori, Kato, Kiminori, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-389-P

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  • Association between Plasma Metabolites in the Urea Cycle and Diabetic Kidney Disease (DKD) in a Japanese Population

    Yamamoto, Masahiko, Harada, Sei, Okamura, Tomonori, Fujihara, Kazuya, Yaguchi, Yuta, Komatsu, Takeshi, Sato, Takaaki, Kitazawa, Masaru, Yamada, Mayuko H., Kaneko, Masanori, Osawa, Taeko, Matsubayashi, Yasuhiro, Yamada, Takaho, Kodama, Satoru, Sone, Hirohito, Takebayashi, Toru

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-518-P

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  • 眼科処置を要する重症糖尿病性眼疾患発生リスクと血液学的因子の関係についての検討 査読

    山本 正彦, 藤原 和哉, 大澤 妙子, 山田 万祐子, 石澤 正博, 石黒 創, 鈴木 浩史, 松林 泰弘, 児玉 暁, 長谷部 日, 曽根 博仁

    糖尿病合併症   33 ( Suppl.1 )   263 - 263   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • Effect of family-oriented diabetes programs on glycemic control: A meta-analysis. 査読 国際誌

    Satoru Kodama, Sakiko Morikawa, Chika Horikawa, Dai Ishii, Kazuya Fujihara, Masahiko Yamamoto, Taeko Osawa, Masaru Kitazawa, Takaho Yamada, Kiminori Kato, Shiro Tanaka, Hirohito Sone

    Family practice   36 ( 4 )   387 - 394   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Efficacy of programs for patients with diabetes mellitus (DM) that have promoted family members to help with patients' self-care activities has been largely inconsistent. This meta-analysis aims to assess the effect of family-oriented diabetes programs for glycemic control (GC). METHODS: Electronic literature searches were conducted for clinical trials with a parallel design wherein there were two groups according to whether family members were included (intervention group) or not included (control group) and changes in glycohemoglobin A1C (A1C) were assessed as a study outcome. Each effect size (i.e. difference in A1C change between the intervention and control group) was pooled with a random-effects model. RESULTS: There were 31 eligible trials consisting of 1466 and 1415 patients in the intervention and control groups, respectively. Pooled A1C change [95% confidence interval (CI)] was -0.45% (-0.64% to -0.26%). Limiting analyses to 21 trials targeted at patients with type 1 DM or 9 trials targeted at patients with type 2 DM, the pooled A1C changes (95% CI) were -0.35% (-0.55% to -0.14%) and -0.71% (-1.09% to -0.33%), respectively. CONCLUSION: This meta-analysis suggests that focusing on the family as well as the individual patient in self-management diabetes programs to improve the performance of self-care activities of patients with DM is effective in terms of proper GC.

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  • Overt Proteinuria, Moderately Reduced eGFR and Their Combination Are Predictive of Severe Diabetic Retinopathy or Diabetic Macular Edema in Diabetes. 査読 国際誌

    Yamamoto M, Fujihara K, Ishizawa M, Osawa T, Kaneko M, Ishiguro H, Matsubayashi Y, Seida H, Yamanaka N, Tanaka S, Kodama S, Hasebe H, Sone H

    Investigative ophthalmology & visual science   60 ( 7 )   2685 - 2689   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1167/iovs.19-26749

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  • Pulse pressure is a stronger predictor than systolic blood pressure for severe eye diseases in diabetes mellitus. 査読

    Yamamoto M, Fujihara K, Ishizawa M, Osawa T, Kaneko M, Ishiguro H, Matsubayashi Y, Seida H, Yamanaka N, Tanaka S, Kodama S, Hasebe H, Sone H

    J Am Heart Assoc   8 ( 8 )   e010627   2019年4月

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  • 血清アミラーゼ値およびその経時変化が2型糖尿病発症に及ぼす影響の定量的検討

    石井 大, 藤原 和哉, 根立 梨奈, 原田 万佑子, 松林 泰弘, 斎藤 和美, 児玉 暁, 森 保道, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 219   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes. 査読

    Osawa T, Fujihara K, Harada M, Yamamoto M, Ishizawa M, Suzuki H, Ishiguro H, Matsubayashi Y, Seida H, Yamanaka N, Tanaka S, Shimano H, Kodama S, Sone H

    Diabetes Metab Res Rev   35 ( 3 )   3120   2019年3月

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    記述言語:英語  

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  • Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study. 査読

    Momma H, Sawada SS, Kato K, Gando Y, Kawakami R, Miyachi M, Huang C, Nagatomi R, Tashiro M, Ishizawa M, Kodama S, Iwanaga M, Fujihara K, Sone H

    J Epidemiol   29 ( 4 )   139 - 146   2019年

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  • Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis. 査読 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Dai Ishii, Mariko Hatta, Yasunaga Takeda, Masaru Kitazawa, Yasuhiro Matsubayashi, Hitoshi Shimano, Kiminori Kato, Shiro Tanaka, Hirohito Sone

    Clinical nutrition ESPEN   27   53 - 58   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND & AIMS: High intake of fruit and vegetables is recommended for cardiovascular health. However, there have been persistent beliefs that fruits having high concentrations of fructose elevate the level of triglycerides (TG) in blood unlike vegetables. This meta-analysis aims to clarify the relationship between fruit intake and TG or hypertriglyceridemia. METHODS: Electronic literature searches were conducted for observational studies that investigated the relationship between fruit intake and hypertriglyceridemia or intervention studies that investigated the effect of increasing fruit intake on TG. Each effect size was pooled with an inverse-variance method. RESULTS: Five cross-sectional studies and only 2 intervention studies were eligible. The pooled odds ratio (OR) (95% confidence interval (CI)) of the 5 cross-sectional studies for the highest vs. the lowest fruit intake category was 0.79 (0.72-0.87). In these studies, the pooled OR for the highest vs. the lowest vegetable intake category was not significant (OR = 0.92; 95% CI, (0.82-1.03)). A linear dose-response association was observed between increases in fruit intake and ORs for hypertriglyceridemia; the OR (95% CI) for an incrementally increased intake of fruit by 1 serving/day was 0.91 (0.84-0.98). CONCLUSION: This meta-analysis suggests that high intake of fruit but not vegetables is inversely associated with hypertriglyceridemia. More trials are needed to clarify whether increasing fruit intake would reduce the level of TG and/or incident hypertriglyceridemia.

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  • Network meta‐analysis of the relative efficacy of bariatric surgeries for diabetes remission 査読

    Kodama S, Fujihara K, Horikawa C, Harada M, Ishiguro H, Kaneko M, Furukawa K, Matsubayashi Y, Matsunaga S, Shimano H, Tanaka S, Kato K, Sone H

    Obesity reviews : an official journal of the International Association for the Study of Obesity   19 ( 12 )   1621 - 1629   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/obr.12751

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  • 糖尿病重症視力障害発症とHbA1cの関連性についての検討 査読

    山本 正彦, 藤原 和哉, 五十嵐 理沙, 石澤 正博, 松林 泰弘, 松永 佐澄志, 伊藤 知恵, 錦野 理絵, 山中 菜詩, 児玉 暁, 曽根 博仁

    日本糖尿病眼学会誌   22   134 - 134   2018年9月

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    記述言語:日本語   出版者・発行元:日本糖尿病眼学会  

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  • 糖尿病重症視力障害発症とHbA1cの関連性についての検討 査読

    山本 正彦, 藤原 和哉, 五十嵐 理沙, 石澤 正博, 松林 泰弘, 松永 佐澄志, 伊藤 知恵, 錦野 理絵, 山中 菜詩, 児玉 暁, 曽根 博仁

    日本糖尿病眼学会誌   22   134 - 134   2018年9月

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    記述言語:日本語   出版者・発行元:日本糖尿病眼学会  

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  • 尿酸高値は非アルコール性脂肪性肝疾患発症の独立したリスク因子である

    原 茂子, 戸田 晶子, 大本 由樹, 辻 裕之, 斎藤 和美, 児玉 暁, 曽根 博仁, 荒瀬 康司

    人間ドック   33 ( 2 )   321 - 321   2018年8月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study. 査読

    Momma H, Sawada SS, Kato K, Gando Y, Kawakami R, Miyachi M, Huang C, Nagatomi R, Tashiro M, Ishizawa M, Kodama S, Iwanaga M, Fujihara K, Sone H

    Journal of epidemiology   29 ( 4 )   139 - 146   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20170280

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  • 耐糖能及び肥満の有無別にみた代謝異常が冠動脈疾患発症に及ぼす影響の検討 査読

    藤原 和哉, 松林 泰弘, 山本 正彦, 金子 正儀, 松永 佐澄志, 山田 貴穂, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁

    日本動脈硬化学会総会プログラム・抄録集   50回   336 - 336   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 耐糖能及び肥満の有無に関わらず代謝異常は冠動脈疾患発症リスクを増大させる 査読

    藤原 和哉, 松林 泰弘, 山本 正彦, 松永 佐澄志, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 260   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 年齢層別に見た血清アミラーゼ値と2型糖尿病発症との関連

    石井 大, 藤原 和哉, 治田 麻理子, 原田 万佑子, 松林 泰弘, 斎藤 和美, 児玉 暁, 森 保道, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 161   2018年4月

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  • Role of fatty liver in the association between obesity and reduced hepatic insulin clearance. 査読

    Matsubayashi Y, Yoshida A, Suganami H, Ishiguro H, Yamamoto M, Fujihara K, Kodama S, Tanaka S, Kaku K, Sone H

    Diabetes Metab   44 ( 2 )   135 - 142   2018年3月

  • Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis 査読

    Kodama Satoru, Hanyu Osamu, Sone Hirohito, Fujihara Kazuya, Ishiguro Hajime, Horikawa Chika, Ohara Nobumasa, Yachi Yoko, Tanaka Shiro, Shimano Hitoshi, Kato Kiminori

    Journal of Epidemiology   28 ( 1 )   3 - 18   2018年

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    記述言語:英語   出版者・発行元:日本疫学会  

    <p>Many epidemiological studies have assessed the genetic risk of having undiagnosed or of developing type 2 diabetes mellitus (T2DM) using several single nucleotide polymorphisms (SNPs) based on findings of genome-wide association studies (GWAS). However, the quantitative association of cumulative risk alleles (RAs) of such SNPs with T2DM risk has been unclear. The aim of this meta-analysis is to review the strength of the association between cumulative RAs and T2DM risk. Systematic literature searches were conducted for cross-sectional or longitudinal studies that examined odds ratios (ORs) for T2DM in relation to genetic profiles. Logarithm of the estimated OR (log OR) of T2DM for 1 increment in RAs carried (1-ΔRA) in each study was pooled using a random-effects model. There were 46 eligible studies that included 74,880 cases among 249,365 participants. In 32 studies with a cross-sectional design, the pooled OR for T2DM morbidity for 1-ΔRA was 1.16 (95% confidence interval [CI], 1.13–1.19). In 15 studies that had a longitudinal design, the OR for incident T2DM was 1.10 (95% CI, 1.08–1.13). There was large heterogeneity in the magnitude of log OR (<i>P</i> < 0.001 for both cross-sectional studies and longitudinal studies). The top 10 commonly used genes significantly explained the variance in the log OR (<i>P</i> = 0.04 for cross-sectional studies; <i>P</i> = 0.006 for longitudinal studies). The current meta-analysis indicated that carrying 1-ΔRA in T2DM-associated SNPs was associated with a modest risk of prevalent or incident T2DM, although the heterogeneity in the used genes among studies requires us to interpret the results with caution.</p>

    DOI: 10.2188/jea.JE20160151

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  • Association of treatment-achieved HbA1c with incidence of coronary artery disease and severe eye disease in diabetes patients 査読

    Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Ishizawa M, Matsubayashi Y, Yamada T, Yamanaka N, Seida H, Kodama S, Ogawa W, Sone H

    Diabetes Metab   2018年

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  • Impact of body mass index and metabolic phenotypes on coronary artery disease according to glucose tolerance status. 査読

    Fujihara K, Matsubayashi Y, Yamamoto M, Osawa T, Ishizawa M, Kaneko M, Matsunaga S, Kato K, Seida H, Yamanaka N, Kodama S, Sone H

    Diabetes & metabolism   43 ( 6 )   543 - 546   2017年12月

  • Critical role of CREBH-mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells. 査読

    Chida T, Ito M, Nakashima K, Kanegae Y, Aoshima T, Takabayashi S, Kawata K, Nakagawa Y, Yamamoto M, Shimano H, Matsuura T, Kobayashi Y, Suda T, Suzuki T

    Hepatology (Baltimore, Md.)   66 ( 5 )   1430 - 1443   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/hep.29319

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  • Carbohydrate intake during early pregnancy is inversely associated with abnormal glucose challenge test results in Japanese pregnant women. 査読 国際誌

    Ryoko Tajima, Yoko Yachi, Yasuhiro Tanaka, Yui Anasako Kawasaki, Izumi Nishibata, Ayumi Sugawara Hirose, Chika Horikawa, Satoru Kodama, Kaoruko Iida, Hirohito Sone

    Diabetes/metabolism research and reviews   33 ( 6 )   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: In East Asian countries, which have a high prevalence of underweight individuals, there is little information about the association between dietary factors and abnormal glucose tolerance during pregnancy. We examined the association between carbohydrate intake and moderately abnormal glucose tolerance in Japanese pregnant women. METHODS: We conducted a prospective study on 325 Japanese pregnant women without a diagnosis of diabetes mellitus prior to pregnancy. Dietary carbohydrate intake (% of total energy intake) was assessed using a 3-day dietary record during weeks 8-15 of pregnancy. Glucose tolerance was assessed by the 50 g glucose challenge test (GCT) during weeks 24-28 of pregnancy. A positive GCT result was defined by a 1-hour plasma concentration ≥ 7.8 mmol/L. Odds ratios of a positive GCT were calculated for the top and middle tertile categories of carbohydrate intake using the bottom category as reference. RESULTS: Mean (standard deviation) body mass index at the first prenatal visit was 19.7 (1.9) kg/m2 , and 95 women were underweight. Seventy-four women had positive GCT results. Carbohydrate intake was negatively associated with a positive GCT result after adjusting for age, parity, body mass index at first prenatal visit, family history of diabetes mellitus, rate of gestational weight gain, energy intake, and dietary fiber intake (odds ratio for top category: 0.46 [95% CI, 0.23-0.93]). CONCLUSIONS: These findings suggest that high carbohydrate intake was negatively associated with moderately abnormal glucose tolerance in a population with a high prevalence of underweight individuals.

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  • Carbohydrate intake during early pregnancy is inversely associated with abnormal glucose challenge test results in Japanese pregnant women 査読

    Ryoko Tajima, Yoko Yachi, Yasuhiro Tanaka, Yui Anasako Kawasaki, Izumi Nishibata, Ayumi Sugawara Hirose, Chika Horikawa, Satoru Kodama, Kaoruko Iida, Hirohito Sone

    DIABETES-METABOLISM RESEARCH AND REVIEWS   33 ( 6 )   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    BackgroundIn East Asian countries, which have a high prevalence of underweight individuals, there is little information about the association between dietary factors and abnormal glucose tolerance during pregnancy. We examined the association between carbohydrate intake and moderately abnormal glucose tolerance in Japanese pregnant women.
    MethodsWe conducted a prospective study on 325 Japanese pregnant women without a diagnosis of diabetes mellitus prior to pregnancy. Dietary carbohydrate intake (% of total energy intake) was assessed using a 3-day dietary record during weeks 8-15 of pregnancy. Glucose tolerance was assessed by the 50g glucose challenge test (GCT) during weeks 24-28 of pregnancy. A positive GCT result was defined by a 1-hour plasma concentration7.8mmol/L. Odds ratios of a positive GCT were calculated for the top and middle tertile categories of carbohydrate intake using the bottom category as reference.
    ResultsMean (standard deviation) body mass index at the first prenatal visit was 19.7 (1.9) kg/m(2), and 95 women were underweight. Seventy-four women had positive GCT results. Carbohydrate intake was negatively associated with a positive GCT result after adjusting for age, parity, body mass index at first prenatal visit, family history of diabetes mellitus, rate of gestational weight gain, energy intake, and dietary fiber intake (odds ratio for top category: 0.46 [95% CI, 0.23-0.93]).
    ConclusionsThese findings suggest that high carbohydrate intake was negatively associated with moderately abnormal glucose tolerance in a population with a high prevalence of underweight individuals.

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  • Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis. 査読

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    Journal of diabetes investigation   8 ( 4 )   501 - 509   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS/INTRODUCTION: The present meta-analysis aimed to clarify the association of unstable bodyweight with the risk of type 2 diabetes mellitus, an association that has been controversial among longitudinal studies. MATERIALS AND METHODS: An electronic literature search using EMBASE and MEDLINE was followed up to 31 August 2016. The relative risks (RRs) of type 2 diabetes mellitus in individuals with unstable bodyweight were pooled using the inverse variance method. RESULTS: Eight studies were eligible for the meta-analysis. The median duration of measurements of weight change and follow-up years for ascertaining type 2 diabetes mellitus were 13.5 and 9.4 years, respectively. The pooled RR for the least vs most stable category was 1.33 (95% confidence interval 1.12-1.57). Between-study heterogeneity was statistically significant (P = 0.048). Whether type 2 diabetes mellitus was ascertained by blood testing explained 66.0% of the variance in the logarithm of RR (P = 0.02). In three studies in which blood testing was carried out, type 2 diabetes mellitus risk was not significant (RR 1.06, 95% confidence interval 0.91-1.25). Furthermore, publication bias that inflated type 2 diabetes mellitus risk was statistically detected by Egger's test (P = 0.09). CONCLUSIONS: Unstable bodyweight might be modestly associated with the elevated risk of type 2 diabetes mellitus; although serious biases, such as diagnostic suspicion bias and publication bias, made it difficult to assess this association.

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  • Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis 査読

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    JOURNAL OF DIABETES INVESTIGATION   8 ( 4 )   501 - 509   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Aims/Introduction: The present meta-analysis aimed to clarify the association of unstable bodyweight with the risk of type 2 diabetes mellitus, an association that has been controversial among longitudinal studies.
    Materials and Methods: An electronic literature search using EMBASE and MEDLINE was followed up to 31 August 2016. The relative risks (RRs) of type 2 diabetes mellitus in individuals with unstable bodyweight were pooled using the inverse variance method.
    Results: Eight studies were eligible for the meta-analysis. The median duration of measurements of weight change and follow-up years for ascertaining type 2 diabetes mellitus were 13.5 and 9.4 years, respectively. The pooled RR for the least vs most stable category was 1.33 (95% confidence interval 1.12-1.57). Between-study heterogeneity was statistically significant (P = 0.048). Whether type 2 diabetes mellitus was ascertained by blood testing explained 66.0% of the variance in the logarithm of RR (P = 0.02). In three studies in which blood testing was carried out, type 2 diabetes mellitus risk was not significant (RR 1.06, 95% confidence interval 0.91-1.25). Furthermore, publication bias that inflated type 2 diabetes mellitus risk was statistically detected by Egger's test (P = 0.09).
    Conclusions: Unstable bodyweight might be modestly associated with the elevated risk of type 2 diabetes mellitus; although serious biases, such as diagnostic suspicion bias and publication bias, made it difficult to assess this association.

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  • Associations between Hypertension and End-Stage Renal Disease (ESRD) in People With and Without Diabetes 査読

    Atsushi Furuya, Kazuya Fujihara, Masahiro Ishizawa, Masahiko Yamamoto, Yasuhiro Matsubayashi, Satoshi Matsunaga, Chie Ito, Mieko Koishi, Nauta Yamanaka, Kiminori Kato, Satoru Kodama, Hirohito Sone

    DIABETES   66   A138 - A138   2017年6月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

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  • Impact of Obesity and Metabolic Phenotypes on Coronary Artery Disease (CAD) According to Glucose Tolerance Status 査読

    Kazuya Fujihara, Satoru Kodama, Masahiko Yamamoto, Satoshi Matsunaga, Yasuhiro Matsubayashi, Masahiro Ishizawa, Mieko Koishi, Chie Ito, Nauta Yamanaka, Kiminori Kato, Hirohito Sone

    DIABETES   66   A406 - A406   2017年6月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.1016/j.diabet.2017.08.002

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  • Impact of glucose tolerance status on the development of coronary artery disease among working-age men. 査読

    Fujihara K, Igarashi R, Yamamoto M, Ishizawa M, Matsubayasi Y, Matsunaga S, Kato K, Ito C, Koishi M, Yamanaka N, Kodama S, Sone H

    DIABETES & METABOLISM   43 ( 3 )   261 - 264   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MASSON EDITEUR  

    Aims. To examine the impact of glucose tolerance status on the development of coronary artery disease (CAD) in working-age men in Japan.
    Methods. This population-based retrospective cohort study included 111,621 men aged 31-60 years [63,558 with normal glucose tolerance (NGT); 37,126 with prediabetes; 10,937 with diabetes]. The Cox proportional-hazards regression model was used to identify variables related to the incidence of CAD.
    Results. Multivariate analysis showed that, compared with NGT, diabetes increased the risk of CAD by 17.3 times (95% CI: 6.36-47.0) at ages 31-40 years, by 2.74 times (95% CI: 1.85-4.05) at ages 41-50 years and by 2.47 times (95% CI: 1.69-3.59) at ages 51-60 years. The HRs for CAD in men with diabetes aged 31-40 equaled that of men with NGT aged 51-60 [18.2 (7.15-46.4) and 19.4 (8.28-45.4), respectively].
    Conclusion. The impact of diabetes on CAD was markedly greater in men aged 31-40 years compared with those aged 41-60 years. (C) 2016 Elsevier Masson SAS. All rights reserved.

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  • Quantitative assessment of genetic testing for type 2 diabetes mellitus based on findings of genome-wide association studies. 査読 国際誌

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    Annals of epidemiology   26 ( 11 )   816 - 818   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    DOI: 10.1016/j.annepidem.2016.09.004

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  • Utility of nonblood-based risk assessment for predicting type 2 diabetes mellitus: A meta-analysis. 査読 国際誌

    Sakiko Yoshizawa, Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Masahiro Ishizawa, Yasuhiro Matsubayashi, Satoshi Matsunaga, Takaho Yamada, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    Preventive medicine   91   180 - 187   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    OBJECTIVE: Nonblood-based risk assessment for type 2 diabetes mellitus (T2DM) that depends on data based on a questionnaire and anthropometry is expected to avoid unnecessary diagnostic testing and overdiagnosis due to blood testing. This meta-analysis aims to assess the predictive ability of nonblood-based risk assessment for future incident T2DM. METHODS: Electronic literature search was conducted using EMBASE and MEDLINE (from January 1, 1997 to October 1, 2014). Included studies had to use at least 3 predictors for T2DM risk assessment and allow reproduction of 2×2 contingency table data (i.e., true positive, true negative, false positive, false negative) to be pooled with a bivariate random-effects model and hierarchical summary receiver-operating characteristic model. Considering the importance of excluding individuals with a low likelihood of T2DM from diagnostic blood testing, we especially focused on specificity and LR-. RESULTS: Eighteen eligible studies consisting of 184,011 participants and 7038 cases were identified. The pooled estimates (95% confidence interval) were as follows: sensitivity=0.73 (0.66-0.79), specificity=0.66 (0.59-0.73), LR+=2.13 (1.81-2.50), and LR-=0.41 (0.34-0.50). CONCLUSIONS: Nonblood-based assessment of risk of T2DM could produce acceptable results although the feasibility of such a screener needs to be determined in future studies.

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  • Impact of individual components and their combinations within a family history of hypertension on the incidence of hypertension: Toranomon hospital health management center study 22. 査読 国際誌

    Igarashi R, Fujihara K, Heianza Y, Ishizawa M, Kodama S, Saito K, Hara S, Hanyu O, Honda R, Tsuji H, Arase Y, Sone H

    Medicine   95 ( 38 )   e4564   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MD.0000000000004564

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  • Body Mass Index (BMI), Waist Circumference (WC) and Waist Height Ratio (WHtR) Cutoff Values, and the Impact of Their Combinations on Future Diabetes among Japanese Individuals 査読

    Risa Igarashi, Kazuya Fujihara, Yoriko Heianza, Masahiro Ishizawa, Megumi Tsuruta, Mariko Hatta, Sakiko Yoshizawa, Chika Hirikawa, Satoshi Matsunaga, Osamu Hanyu, Satoru Kodama, Koji Sato, Kiminori Kato, Hirohito Sone

    DIABETES   65   A519 - A520   2016年6月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

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  • Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 21 査読

    Yoriko Heianza, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Shiro Tanaka, Satoru Kodama, Tetsuro Kobayashi, Yasuji Arase, Hirohito Sone

    DIABETES RESEARCH AND CLINICAL PRACTICE   113   60 - 68   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: Whether early stages of kidney dysfunction assessed by the estimated glomerular filtration rate from cystatin C measurements (eGFRCysC) rather than from creatinine measurements (eGFRCr) would more precisely reflect the risk of developing type 2 diabetes (T2D) has not been clarified. We compared the risk of developing T2D associated with renal dysfunction indicated by eGFRCysC or eGFRCr measurements.
    Methods: Studied were 2131 Japanese individuals without diabetes. Hazard ratios (HRs) for the development of T2D over 3-5 y were calculated across categories of eGFRCysC and eGFRCr, respectively.
    Results: Reduced levels of eGFRCysC were associated with a step-wise increase in the cumulative incidence rate of T2D (p = 0.007). In comparison with the eGFRCysC &gt;85th percentile group (&gt;= 117.4 ml/min/1.73 m(2)), the lowest group, which was the eGFRCysC &lt;15th percentile group (&lt;86.2 ml/min/1.73 m(2)), had an adjusted HR of 2.30 (95% CI 1.13, 4.68) for T2D. Compared with the eGFRCr &gt;85th percentile group, the lowest eGFRCr group (&lt;15th percentile) had an HR of 1.19 (0.63, 2.24) for T2D. However, individuals with eGFRCr &lt;60 ml/min/1.73 m(2) had a significantly increased risk of T2D. Clustering of both low eGFRCysC and low eGFRCr further elevated the HR for T2D compared with the presence of either.
    Conclusions: Although eGFRCr in ranges indicating chronic kidney disease reflected an elevated risk of developing diabetes, earlier stages of kidney dysfunction indicated by reduced eGFRCysC, which could not be captured by reduced eGFRCr, would be a marker for an elevated risk of developing T2D. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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  • Meta-analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus. 査読 国際誌

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    Diabetes/metabolism research and reviews   32 ( 2 )   178 - 86   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Our aim is to examine the dose-response association between cumulative genetic risk and actual risk of type 2 diabetes mellitus (T2DM) and the influence of adjustment for covariates on T2DM risk through a comprehensive meta-analysis of observational studies. METHODS: Electronic literature search using EMBASE and MEDLINE (from 2003 to 2014) was conducted for cross-sectional or longitudinal studies that presented the odds ratio (OR) for T2DM in each group with categories based on the total number of risk alleles (RAs) carried (RAtotal ) using at least two single-nucleotide polymorphisms. Spline regression model was used to determine the shape of the relationship between the difference from the referent group of each study in RAtotal (ΔRAtotal ) and the natural logarithms of ORs (log OR) for T2DM. RESULTS: Sixty-five eligible studies that included 68 267 cases among 182 603 participants were analysed. In both crude and adjusted ORs, defined by adjusting the risk for at least two confounders among age, gender and body mass index, the slope of the log OR for T2DM became less steep as the ΔRAtotal increased. In the analysis limited to 14 cross-sectional and four longitudinal studies presenting both crude and adjusted ORs, regression curves of both ORs in relation to ΔRAtotal were almost identical. CONCLUSION: Using only single-nucleotide polymorphisms for T2DM screening was of limited value. However, when genotypic T2DM risk was considered independently from risk in relation to covariates, it was suggested that genetic profiles might have a supplementary role related to conventional T2DM risk factors in identifying individuals at high risk of T2DM. Copyright © 2015 John Wiley & Sons, Ltd.

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  • Meta-analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus. 査読 国際誌

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    Diabetes/metabolism research and reviews   32 ( 2 )   178 - 86   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    BACKGROUND: Our aim is to examine the dose-response association between cumulative genetic risk and actual risk of type 2 diabetes mellitus (T2DM) and the influence of adjustment for covariates on T2DM risk through a comprehensive meta-analysis of observational studies. METHODS: Electronic literature search using EMBASE and MEDLINE (from 2003 to 2014) was conducted for cross-sectional or longitudinal studies that presented the odds ratio (OR) for T2DM in each group with categories based on the total number of risk alleles (RAs) carried (RAtotal ) using at least two single-nucleotide polymorphisms. Spline regression model was used to determine the shape of the relationship between the difference from the referent group of each study in RAtotal (ΔRAtotal ) and the natural logarithms of ORs (log OR) for T2DM. RESULTS: Sixty-five eligible studies that included 68 267 cases among 182 603 participants were analysed. In both crude and adjusted ORs, defined by adjusting the risk for at least two confounders among age, gender and body mass index, the slope of the log OR for T2DM became less steep as the ΔRAtotal increased. In the analysis limited to 14 cross-sectional and four longitudinal studies presenting both crude and adjusted ORs, regression curves of both ORs in relation to ΔRAtotal were almost identical. CONCLUSION: Using only single-nucleotide polymorphisms for T2DM screening was of limited value. However, when genotypic T2DM risk was considered independently from risk in relation to covariates, it was suggested that genetic profiles might have a supplementary role related to conventional T2DM risk factors in identifying individuals at high risk of T2DM. Copyright © 2015 John Wiley & Sons, Ltd.

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  • In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. 査読 国際誌

    Hajime Ishiguro, Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Ayumi Sugawara Hirose, Reiko Hirasawa, Yoko Yachi, Nobumasa Ohara, Hitoshi Shimano, Osamu Hanyu, Hirohito Sone

    Sports medicine (Auckland, N.Z.)   46 ( 1 )   67 - 77   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ADIS INT LTD  

    BACKGROUND: Resistance training (RT) is effective for glycemic control in type 2 diabetes mellitus (T2DM) patients. However, the characteristics of an RT program that will maximize its effect and those of patients that will especially benefit from RT are unknown. OBJECTIVE: The objectives of this systematic review were to identify via a comprehensive meta-analysis the characteristics of an RT program for patients with T2DM that might increase the patients' improvement in glycemic control and the characteristics of patients that will benefit from RT. DATA SOURCES: Electronic-based literature searches of MEDLINE and EMBASE entries from 1 January 1966 to 25 August 2014 were conducted to identify clinical trials examining the effect of RT on glycemic control among patients with T2DM. Study keywords were text words and thesaurus terms related to RT and T2DM. STUDY SELECTION: Studies were included if they (1) were clinical trials consisting of two groups with and without RT exercise intervention; (2) had an intervention period of at least 5 weeks; (3) clarified that all patients had T2DM; and (4) reported or made it possible to estimate the effect size [i.e., change in glycosylated hemoglobin (HbA1c) in the RT group minus that in the control group] and its corresponding standard error. STUDY APPRAISAL AND SYNTHESIS METHODS: The effect size in each study was pooled with a random-effects model. Analyses were stratified by several key characteristics of the patients and RT exercise programs; meta-regression analysis was then used to detect a difference in the effect size among strata within each factor. Linear regression analyses were added by entering each of the following profiles: patients' baseline characteristics [mean baseline age, body mass index (BMI), and HbA1c levels] and exercise characteristics (total sets per week, total sets per bout of exercise, frequency, and intensity). RESULTS: There were 23 eligible studies comprising 954 patients with T2DM. The pooled effect size (95% confidence interval) was -0.34% (-0.53 to -0.16). A program with multiple sets (≥21 vs. <21) per one RT bout was associated with a large effect size (P = 0.03); however, the linear correlation between the number of sets and effect size was not significant (P = 0.56). A larger effect size was observed in studies with participants with diabetes of a relatively short duration (<6 vs. ≥6 years; P = 0.04) or a high baseline HbA1c [≥7.5% (58 mmol/mol) vs. <7.5 %; P = 0.01] while a smaller effect size was observed in studies with a particularly high mean baseline BMI value (≥32 vs. <32 kg/m(2); P = 0.03). Linear regression analyses predicted that each increment of 1% in the baseline HbA1c would enlarge the effect size by 0.036%, while each increment of 1 kg/m2 in the baseline BMI decreased it by 0.070% in the range between 22.3 and 38.8 kg/m2. CONCLUSION: In terms of glycemic control, RT could be recommended in the early stage of T2DM, especially for patients with relatively poor glycemic control. More benefit would be elicited in less obese patients within a limited range of the BMI. A substantial amount of exercise might be required to stimulate post-exercise glucose uptake, although the dose-dependency was not specifically clarified.

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  • Trajectory of body mass index before the development of type 2 diabetes in Japanese men: Toranomon Hospital Health Management Center Study 15. 査読

    Heianza Y, Arase Y, Kodama S, Tsuji H, Tanaka S, Saito K, Hara S, Sone H

    Journal of diabetes investigation   6 ( 3 )   289 - 294   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jdi.12308

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  • Risk of the development of Type 2 diabetes in relation to overall obesity, abdominal obesity and the clustering of metabolic abnormalities in Japanese individuals: does metabolically healthy overweight really exist? The Niigata Wellness Study. 査読

    Diabet Med   32 ( 5 )   665 - 672   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Fasting glucose and HbA1c levels as risk factors for the development of hypertension in Japanese individuals: Toranomon hospital health management center study 16 (TOPICS 16) 査読

    Y. Heianza, Y. Arase, S. Kodama, S. D. Hsieh, H. Tsuji, K. Saito, S. Hara, H. Sone

    Journal of Human Hypertension   29 ( 4 )   254 - 259   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nature Publishing Group  

    We investigated the effect of elevated concentrations of fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c) on the risk of development of hypertension among apparently healthy Japanese. Studied were 9584 individuals without known diabetes and hypertension. During a 5-year follow-up period, 1098 individuals developed hypertension. Elevated concentrations of FPG, rather than of HbA1c, were significantly predictive of future hypertension. Compared with the lowest quartile category of FPG (&lt
    4.9 mmol l-1), the second (4.9-&lt
    5.2 mmol l-1), third (5.2-&lt
    5.6 mmol l-1) and highest (≥ 5.6 mmol l-1) quartile categories had age-, sex- and body mass index-adjusted odds ratios (95% confidence interval) of 1.35 (1.10, 1.66), 1.39 (1.13, 1.71) and 1.85 (1.51, 2.28) for hypertension, respectively. In the highest quartile of FPG, the multivariate-adjusted OR was 1.37 (1.10, 1.70) compared with the lowest quartile. Results of these adjusted models showed no significant association across quartile categories of HbA1c concentrations and an increased risk of developing hypertension. The joint effect of hyperglycemia and overweight, older age or prehypertension resulted in further elevated ORs for hypertension than the absence of such an association. Higher FPG levels rather than HbA1c were strongly predictive of future hypertension among Japanese. Hyperglycemia along with older age, overweight and prehypertension contributed to identifying individuals at increased risk of developing hypertension.

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  • Potential impact of joint association of alanine aminotransferase and gamma-glutamyltransferase on insulin resistance in Japan: The Toranomon Hospital Health Management Center Study 19 (TOPICS 19) 査読

    Yasuji Arase, Yoriko Heianza, Shigeko Hara, Yuki Ohmoto-Sekine, Kazuhisa Amakawa, Hiroshi Tsuji, Kyoko Ogawa, Kazumi Saito, Satoru Kodama, Kenji Ikeda, Hiromitsu Kumada, Tetsuro Kobayashi, Hirohito Sone

    HEPATOLOGY RESEARCH   45 ( 3 )   247 - 258   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    AimTo investigate the potential impact of joint association of alanine aminotransferase (ALT) and -glutamyltransferase (GGT) on insulin resistance and -cell dysfunction in healthy Japanese individuals with a normal range of liver enzymes.
    MethodsThis study included 1010 individuals (545 men and 465 women) aged 20-89 years who underwent an oral glucose tolerance test for health screening. Participants were divided into four groups on the basis of median values for ALT and GGT: (i) both ALT and GGT low (both-low); (ii) ALT high and GGT low (ALT-high); (iii) ALT low and GGT high (GGT-high); and (iv) both ALT and GGT high (both-high). Logistic regression analysis was used to investigate the relationship between liver enzyme and insulin dynamics, such as Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) and insulinogenic index (IGI). The insulin resistance was defined when HOMA-IR was 2.5 or more. IGI of less than 0.4 was considered to be decreased early-phase insulin secretion.
    ResultsMean values of HOMA-IR in men was 1.5 in the both-low group, 1.8 in ALT-high, 1.8 in GGT-high and 2.8 in both-high. The mean HOMA-IR in women was 1.3 in the both-low group, 1.3 in ALT-high, 1.6 in GGT-high and 2.0 in both-high. HOMA-IR in the both-high group was significantly higher than that in the both-low group regardless of the difference of sex. Multivariate analysis showed that insulin resistance occurred when the patient had high liver enzymes.
    ConclusionCombining the two liver function markers would be effective for identifying individuals with insulin resistance.

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  • Simple self-reported behavioral or psychological characteristics as risk factors for future type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 14 査読

    Yoriko Heianza, Yasuji Arase, Satoru Kodama, Hiroshi Tsuji, Kazuya Fujihara, Kazumi Saito, Shigeko Hara, Hirohito Sone

    JOURNAL OF DIABETES INVESTIGATION   6 ( 2 )   236 - 241   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Aims/IntroductionDepression, anger, sleep disorders and cognitive impairment are regarded as presenting a high risk for diabetes. We investigated whether responses to single statements on a self-report questionnaire on the presence of each of these four factors were associated with the development of type 2 diabetes.
    Materials and MethodsWe investigated 3,211 Japanese individuals without diabetes. Cumulative incidence rate and hazard ratios (HRs) for future type 2 diabetes over 7-13years were evaluated according to the presence of lack of perseverance, anger, memory loss or sleep disorders.
    ResultsResults of Cox regression analysis showed that lack of perseverance (age- and sex-adjusted HR 1.41, 95% confidence interval 1.07-1.84), anger, (HR 1.51, 95% confidence interval 1.07-2.12) or memory loss (HR 1.47, 95% confidence interval 1.14-1.90) was predictive of the development of diabetes. Even after adjustment for metabolic factors including glycemic measurements, anger was significantly associated with an increased risk of future diabetes. Individuals with both anger and memory loss had a 1.94-fold (95% confidence interval 1.19-3.15) increased risk of type2 diabetes than those without those two symptoms.
    ConclusionsResponses to a simple self-report questionnaire as to whether individuals were aware of anger or memory loss were associated with the development of type2 diabetes independent of traditional risk factors for diabetes in this cohort of Japanese individuals.

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  • [Closed Septorhinoplasty for Caudal Septum Deviation: A Japanese Rhinologic Perspective]. 査読

    Kodama S, Tateyama K, Nomi N, Suzuki M

    Nihon Jibiinkoka Gakkai kaiho   118 ( 2 )   129 - 134   2015年2月

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  • Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes 査読

    Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hiroaki Yagyu, Hirohito Sone, Hitoshi Shimano

    JOURNAL OF DIABETES RESEARCH   2015   507245   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI PUBLISHING CORPORATION  

    Aims. To elucidate the levels of malondialdehyde-modified LDL (MDA-LDL)-related variables for predicting coronary artery stenosis (CAS) by coronary CT angiography (CCTA) in asymptomatic patients with type 2 diabetes (T2DM). Methods. Enrolled were 36 Japanese patients with T2DM who underwent CCTA and in whom MDA-LDL levels were measured. Definition of CAS was luminal narrowing of &gt;= 50%. Trends through tertiles of each MDA-LDL-related variable were analyzed with a general linear model. The ability of each MDA-LDL-related variable to predict CAS was compared to areas under the curve (AUCs) in receiver operating characteristic curve (ROC) analysis. Results. Seventeen patients had CAS. Each MDA-IDL-related variable was an independent predictor of CAS (P = 0.039 for MDALDL, P = 0.013 for MDA-LDL/LDL-C, P = 0.047 for MDA-LDL/HDL-C, and P = 0.013 for (MDA-LDULDL-C)/HDL-C). AUCs of MDA-LDL, MDA-LDL/LDL-C, MDA-LDL/HDL-C, and (MDA-LDULDLC)/HDL-C were 0.675 (95% CI 0.496-0.854), 0.765 (0.602-0.927), 0.752 (0.592-0.913), and 0.799 (0.643-0.955), respectively, for predicting CAS. Trends throughout the tertiles showed significant associations between N4DA-LDL/LDL-C, N4DA-LDL/41DL-C, or (MDALDL/LDL-C)/41DL-C and CAS (P 0.003 for MDA-LDL/LDL-C, P=0.042 for MDA-LDULIDL-C, and P 0.001 for (MDA-LDULDL-C)/HDL-C). Conclusions. Data suggest that measurements of MDA-LDL/LDL-C, MDA-LDL/HDLC, and (MakLDULDL-C)/HDL-C are useful for predicting CAS.

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  • An endoscopic endonasal approach for early-stage olfactory neuroblastoma: an evaluation of 2 cases with minireview of literature. 査読

    Yokoi H, Kodama S, Kogashiwa Y, Matsumoto Y, Ohkura Y, Nakagawa T, Kohno N

    Case reports in otolaryngology   2015   541026   2015年

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    記述言語:英語   出版者・発行元:Hindawi Publishing Corporation  

    We describe the clinical findings in two patients with pathologically diagnosed olfactory neuroblastoma (ONB) of the sinonasal area and the surgical methods used for its treatment. Using an endoscopic endonasal approach (EEA) without dura resection, along with radiotherapy, we successfully treated ONB at the Kadish stage A. One of our patients, however, experienced tumor recurrence 24 years after open surgery with radiotherapy that was conducted at another hospital. This patient was no longer eligible for radiotherapy, and the tumor was therefore resected with dura resection using an EEA combined with duraplasty. The dura resection with duraplasty using fascia lata and a pedicled nasal septal flap was minimally invasive. As with surgery without duraplasty, a postoperative computed tomography (CT) examination revealed that EEA with duraplasty led to quick improvement of the postoperative inflammatory response as well as pneumocranium. Here, we investigated whether to modify the method of surgery depending upon the primary site of early-stage ONB. We suggest that, in early-stage ONB, an endoscopic endonasal approach is an effective and less invasive method. It is also advisable to perform dura mater resection of the lesion site despite the absence of obvious intracranial invasions in image findings.

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  • High cholesterol intake is associated with elevated risk of type 2 diabetes mellitus - a meta-analysis. 査読 国際誌

    Ryoko Tajima, Satoru Kodama, Miho Hirata, Chika Horikawa, Kazuya Fujihara, Yoko Yachi, Sakiko Yoshizawa, Kaoruko Tada Iida, Hirohito Sone

    Clinical nutrition (Edinburgh, Scotland)   33 ( 6 )   946 - 50   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CHURCHILL LIVINGSTONE  

    BACKGROUND & AIMS: Some foods rich in cholesterol are associated with high risk of type 2 diabetes (T2D). To confirm the association between dietary cholesterol intake and T2D risk, we performed a meta-analysis of observational studies. METHODS: We searched for longitudinal studies that provided data on the relative risk (RR) for T2D in relation to the cholesterol intake level using MEDLINE (from 1950 for July 10, 2013) and EMBASE (from 1974 to July 10, 2013). The RR for the highest vs. lowest cholesterol intake category or for an increment of 100 mg/day in cholesterol consumption was pooled with an inverse-variance method. RESULTS: Five studies met the inclusion criteria. Compared with the lowest category, the highest category had a significantly higher association with T2D risk (RR [95% confidence interval (CI)], 1.25 [1.16-1.36]). The pooled RR for a 100-mg/day increment was also significant (RR [95% CI], 1.11 [1.06-1.15]). CONCLUSION: Current meta-analysis suggested that high intake of cholesterol was positively associated with future T2D risk.

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  • Impact on short-term glycaemic control of initiating diabetes care versus leaving diabetes untreated among individuals with newly screening-detected diabetes in Japan 査読

    Yoriko Heianza, Akiko Suzuki, Kazuya Fujihara, Shiro Tanaka, Satoru Kodama, Osamu Hanyu, Hirohito Sone

    JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH   68 ( 12 )   1189 - 1195   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ PUBLISHING GROUP  

    Background The impact of early initiation of diabetes care soon after the identification of hyperglycaemia rather than leaving diabetes untreated on changes in glycaemic control has not been fully clarified. We aimed to quantify the effect of initiating and continuing diabetes care compared with not starting management of diabetes on short-term changes in glycaemic control among the Japanese with newly screening-detected diabetes.
    Methods We retrospectively reviewed data from a nationwide claims database to assess histories of physician-diagnosed diabetes or hyperglycaemia, as well as the use of antidiabetic agents, blood testing for hyperglycaemia or dietary advice among individuals without a history of diabetes care. Changes in glycated haemoglobin (HbA1c) concentrations were evaluated using baseline data and data from a health examination during the following year.
    Results Among 1393 individuals with newly screening-detected diabetes, 62% (n=864) did not initiate diabetes management during the follow-up period; 49.2% (n=425) of the untreated group had poor glycaemic control (HbA1c =7%) at the baseline examination. Only 38% (n=529) began diabetes management in medical settings. Individuals who remained untreated had a 1.87 (95% CI 1.38 to 2.52) or 1.63 (1.10 to 2.41) times higher risk of absolute increases in HbA1c &gt;= 0.5% or &gt;= 1%, respectively, compared with the treated patients, a difference that was significant. Making more frequent clinic visits especially after the first visit was dose-dependently associated with improved HbA1c levels compared with no diabetes management.
    Conclusions In comparison with a lack of management of diabetes, immediately initiating and continuing diabetes care after identification of hyperglycaemia in a screening setting would contribute to clinically meaningful, improved glycaemic control in the Japanese.

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  • Stability and Changes in Metabolically Healthy Overweight or Obesity and Risk of Future Diabetes: Niigata Wellness Study 査読

    Yoriko Heianza, Kiminori Kato, Satoru Kodama, Akiko Suzuki, Shiro Tanaka, Osamu Hanyu, Koji Sato, Hirohito Sone

    OBESITY   22 ( 11 )   2420 - 2425   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    ObjectiveStability and changes in obesity and metabolic health status from a baseline period and longitudinally investigated their impact on predicting future diabetes were assessed.
    MethodsStudied were 27,478 Japanese individuals without diabetes. Metabolically healthy (MH) was indicated by having 1 among impaired fasting glucose, hypertension, hypertriglyceridemia and low HDL cholesterol concentration. Metabolically abnormal (MA) was indicated by having 2 of those metabolic abnormalities. A cut-off value of BMI 25.0 defined overweight or obesity (O) or normal weight (NW). Hazard ratio (HR) for diabetes for a 6-year period was investigated after changes in phenotypes were assessed during the previous 2 years.
    ResultsCompared with maintaining MH-NW, transitioning to MH-O from MH-NW resulted in a multivariate-adjusted HR of 1.96 (95% CI: 1.18, 3.25) for diabetes. With a stable MH-O the HR for diabetes was 2.59 (2.00, 3.34) while change from MH-O to MH-NW resulted in an HR of 1.30 (0.61, 2.76). Transitioning to MA-O from MH-O was associated with an HR of 7.09 (5.41, 9.30). With a stable MA-O the risk of diabetes was substantially elevated with an HR of 12.5 (10.5, 14.9).
    ConclusionsExamining the transitory nature of apparently benign or unhealthy obese phenotypes was effective for differentiating high-risk individuals for future diabetes.

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  • Comparison of different aspects of BMI history to identify undiagnosed diabetes in Japanese men and women: Toranomon Hospital Health Management Center Study 12 (TOPICS 12) . 査読

    Diabet Med   31 ( 11 )   1378 - 1386   2014年11月

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    記述言語:英語  

    DOI: 10.1111/dme.12471

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  • Role of sleep duration as a risk factor for Type 2 diabetes among adults of different ages in Japan: the Niigata Wellness Study 査読

    Y. Heianza, K. Kato, K. Fujihara, S. Tanaka, S. Kodama, O. Hanyu, K. Sato, H. Sone

    DIABETIC MEDICINE   31 ( 11 )   1363 - 1367   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    AimTo compare the role of short sleep duration as a risk factor for diabetes among adults of different ages.
    MethodsThe study enrolled 38987 Japanese individuals without diabetes, and the 8-year risk of developing diabetes attributable to different sleep durations (&lt;5.5h, 5.5 to &lt;6.5h, 6.5 to &lt;7.0h, 7.0-7.5h, &gt;7.5-8.0h, or &gt;8.0h) was assessed among individuals aged 45, 46-59 or 60years.
    ResultsDuring the 8-year follow-up period, 2085 individuals developed diabetes. Overall, individuals with a short sleep duration of &lt;5.5h or 5.5 to &lt;6.5h had, respectively, a 1.53-fold (95% CI 1.19, 1.97) or 1.25-fold (95% CI 1.10, 1.42) increased risk of diabetes as compared with those who had 7.0-7.5h of sleep. A sleep duration of &lt;5.5h or 5.5 to &lt;6.5h was predictive of the development of diabetes among individuals aged 45years, but not among those aged 60years. With increasing age, the effect of short sleep duration on the risk of diabetes was attenuated.
    ConclusionsShort sleep duration was predictive of diabetes among young or middle-aged Japanese adults but not among elderly individuals after age was considered. Managing habitual short sleep and the possible reasons for having such short sleep duration could be particularly important for young or middle-aged adults in the development of future diabetes.

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  • High risk of failing eradication of Helicobacter pylori in patients with diabetes: a meta-analysis. 査読

    Horikawa C, Kodama S, Fujihara K, Hirasawa R, Yachi Y, Suzuki A, Hanyu O, Shimano H, Sone H

    Diabetes research and clinical practice   106 ( 1 )   81 - 87   2014年10月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.diabres.2014.07.009

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  • Second trimester postload glucose level as an important predictor of low birth weight infants: Tanaka Women's Clinic Study 査読

    Yoko Yachi, Yasuhiro Tanaka, Izumi Nishibata, Sakiko Yoshizawa, Kazuya Fujihara, Satoru Kodama, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

    DIABETES RESEARCH AND CLINICAL PRACTICE   105 ( 3 )   E16 - E19   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Although it is well known that the maternal prepregnancy BMI is a strong contributor to fetal growth, our results showed that a low postload glucose level, although within normal range, independent of maternal BMI was strongly associated with an increased risk of low birth weight births among Japanese mothers. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

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  • Metabolically Healthy Obesity, Presence or Absence of Fatty Liver, and Risk of Type 2 Diabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20) 査読

    Yoriko Heianza, Yasuji Arase, Hiroshi Tsuji, Kazuya Fujihara, Kazumi Saito, Shiun Dong Hsieh, Shiro Tanaka, Satoru Kodama, Shigeko Hara, Hirohito Sone

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   99 ( 8 )   2952 - 2960   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ENDOCRINE SOC  

    Objective: We investigated whether the metabolically healthy obese (MHO) phenotype was associated with an increased risk of the development of diabetes. If so, we aimed to determine what factors could explain this finding.
    Design, Setting, and Participants: Studied were 8090 Japanese individuals without diabetes. Metabolic health status was assessed by common clinical markers: blood pressure, triglycerides, high-density lipoprotein-cholesterol, and fasting glucose concentrations. The cutoff value for obesity or normal weight (NW) was a body mass index of 25.0 kg/m(2).
    Results: The 5-year incidence rate of diabetes was 1.2% (n = 58 of 4749) in metabolically healthy NW (MHNW) individuals, 2.8% (n = 20 of 719) in MHO individuals, 6.0% (n = 102 of 1709) in metabolically abnormalNWindividuals, and 10.3%(n = 94 of 913) in metabolically abnormal obese individuals. Although MHO individuals had no or one metabolic factor, 47.8% had ultrasonographic fatty liver (FL). The MHO group had a significantly increased risk of diabetes compared with the MHNW group [multivariate adjusted odds ratio (OR) 2.23 (95% confidence interval [CI] 1.33, 3.75)], but this risk was attenuated after adjustment for FL. Compared with the MHNW/non-FL group, the risk of diabetes in the MHO/non-FL group was not significantly elevated [OR 1.01 (95% CI 0.35, 2.88)]. However, the MHO/FL and MHNW/FL groups had similarly elevated risks of diabetes [OR 4.09 (95% CI 2.20, 7.60) and 3.16 (1.78, 5.62), respectively].
    Conclusions: Almost half of the MHO participants had FL, which partially explained the increased risk of diabetes among the obese phenotypes. The presence of FL should be evaluated to assess whether an individual was actually in a metabolically benign state for the prediction of diabetes.

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  • Evaluation of adenotonsillectomy and tonsillectomy for pediatric obstructive sleep apnea by rhinomanometry and the OSA-18 questionnaire 査読

    Ryuichi Kobayashi, Soichiro Miyazaki, Masayuki Karaki, Hiroshi Hoshikawa, Seiichi Nakata, Hirotaka Hara, Satoru Kodama, Atsushi Kikuchi, Takuro Kitamura, Nozomu Mori

    ACTA OTO-LARYNGOLOGICA   134 ( 8 )   818 - 823   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INFORMA HEALTHCARE  

    Conclusion: Nasal resistance and the OSA-18 score were useful for evaluating surgical treatments. The sleep disturbance score may also be useful for predicting the severity of obstructive sleep apnea (OSA) in children. Objective: We evaluated the effect of surgery on children with OSA using polysomnography (PSG) parameters, nasal resistance, and the OSA-18 questionnaire, and also investigated the cut-off OSA-18 score to screen for pediatric OSA. Methods: This was a retrospective study in which PSG parameters and nasal resistance were measured using a rhinomanometer and the OSA-18 score was obtained from the OSA-18 questionnaire before and after surgery in 45 children with OSA. Results: The mean age of the 45 patients was 5.7 +/- 2.0 years. The mean value of the obstructive apnea hypopnea index (O-AHI) improved from 16.2 +/- 14.3/h before surgery to 1.1 +/- 1.7/h after surgery, the mean nasal resistance improved from 0.44 +/- 0.19 to 0.32 +/- 0.10 Pa/cm(3)/s, and the mean OSA-18 score improved from 61.1 + 13.7 to 30.4 + 5.8, and all these improvements were significant. The O-AHI value was lower than 1/h after surgery in 64.4% of patients (29/45). The O-AHI value was significantly correlated with the sleep disturbance score (r = 0.352, p = 0.018). When the cut-off OSA-18 score for screening was set at 40, sensitivity was 100%.

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  • Role of Body Mass Index History in Predicting Risk of the Development of Hypertension in Japanese Individuals Toranomon Hospital Health Management Center Study 18 (TOPICS 18) 査読

    Yoriko Heianza, Satoru Kodama, Yasuji Arase, Shiun Dong Hsieh, Sakiko Yoshizawa, Hiroshi Tsuji, Kazumi Saito, Shiro Tanaka, Shigeko Hara, Hirohito Sone

    HYPERTENSION   64 ( 2 )   247 - +   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    It has not been clarified whether overall adiposity in early adulthood or at the lifetime maximum weight would confer a residual risk of hypertension after considering the risk associated with current adiposity. Studied were 6121 Japanese without hypertension. The risk of developing hypertension 4 years after a baseline examination was investigated using the body mass index in the early 20s, at the lifetime maximum, or at the baseline examination. An elevated body mass index at baseline or at the maximum rather than in the early 20s was strongly associated with future hypertension. Compared with individuals with low body mass index both at baseline and in the early 20s, those with an elevated body mass index at the baseline alone had an odds ratio of 1.89 (95% confidence interval, 1.58-2.27) and those with an elevated body mass index both at baseline and in the early 20s had the highest odds ratio of 2.26 (1.76-2.89). Individuals with an elevated body mass index both at baseline and at the maximum had a 2.26-fold (1.87-2.72) increased risk of hypertension compared with those without the 2 factors. An elevated body mass index at the baseline examination weakened the favorable influence of a low body mass index in early adulthood on developing hypertension. Adding information on body mass index in early adulthood or at the maximum in addition to that at the baseline examination contributed to differentiating the risk of hypertension among Japanese, particularly among those with an elevated overall adiposity at present.

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  • Meta-analysis of the quantitative relation between pulse pressure and mean arterial pressure and cardiovascular risk in patients with diabetes mellitus. 査読 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Sakiko Yoshizawa, Yoko Yachi, Shiro Tanaka, Nobumasa Ohara, Satoshi Matsunaga, Takaho Yamada, Osamu Hanyu, Hirohito Sone

    The American journal of cardiology   113 ( 6 )   1058 - 65   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC  

    Results of epidemiologic studies that investigated the significance of pulse pressure (PP) and mean arterial pressure (MAP) in terms of risk of cardiovascular disease (CVD) in patients with diabetes mellitus are inconsistent. We performed a quantitative meta-analysis to estimate CVD risk in relation to PP or MAP. Electronic literature search was conducted for prospective studies providing data on CVD risk for an increment in baseline MAP or PP in patients with diabetes mellitus. The pooled CVD risk for a 10-mm Hg increase in each blood pressure (BP) index was estimated with a random-effects model. There were 17 eligible studies consisting of 52,647 patients and 5,112 CVD cases. The pooled relative risk (95% confidence interval) of CVD for an increment of 10 mm Hg was 1.10 (1.04 to 1.16) for PP and 1.09 (0.98 to 1.21) for MAP. Significant between-study heterogeneity was observed (I(2) [p value]; 76.5% [p <0.001] for PP, 67.8% [p = 0.005] for MAP). In studies concurrently investigating CVD risk for the 4 indexes (i.e., PP, MAP, systolic BP, and diastolic BP), the pooled relative risk (95% confidence interval) was 1.17 (1.09 to 1.26) for PP, 1.11 (1.06 to 1.15) for MAP, 1.14 (1.06 to 1.22) for systolic BP, and 1.06 (0.94 to 1.19) for diastolic BP. In conclusion, the current meta-analysis suggested that PP was the strongest indicator among the 4 commonly used BP indexes. However, the large heterogeneity urged cautious interpretation of the study results.

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  • Quantitative relationship between body weight gain in adulthood and incident type 2 diabetes: a meta-analysis. 査読 国際誌

    Kodama S, Horikawa C, Fujihara K, Yoshizawa S, Yachi Y, Tanaka S, Ohara N, Matsunaga S, Yamada T, Hanyu O, Sone H

    Obesity review   15 ( 3 )   202 - 214   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/obr.12129

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  • Efficacy of habitual exercise for improving lipid profiles depends on the PPRAγ genotype in Japanese males. 査読

    Sone Y, Hirasawa R, Ichi I, Ishikawa T, Kodama S, Sone H, Egawa S, Kawahara K, Otsuka Y, Fujiwara Y

    Journal of nutritional science and vitaminology   60 ( 1 )   66 - 70   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3177/jnsv.60.66

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  • Association of Helicobacter pylori infection with glycemic control in patients with diabetes: a meta-analysis. 査読 国際誌

    Chika Horikawa, Satoru Kodama, Kazuya Fujihara, Yoko Yachi, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Hitoshi Shimano, Hirohito Sone

    Journal of diabetes research   2014   250620 - 250620   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI PUBLISHING CORPORATION  

    OBJECTIVE. To assess the association between Helicobacter pylori (HP) infection and glycemic control in patients with diabetes through a meta-analytic approach. RESEARCH DESIGN AND METHODS. Electronic literature searches were conducted for cross-sectional studies that examined the hemoglobin A1c (A1C) level by whether patients with diabetes were or were not carriers of HP. Mean differences in A1C between groups with and without HP infection were pooled with a random-effects model. RESULTS. Thirteen eligible studies were included in this meta-analysis. Overall, the HP carriers did not have significantly higher A1C levels compared with HP noncarriers (mean difference (95% CI), 0.19% (-0.18 to 0.46), P = 0.16). When the analysis was limited to studies targeting patients with type 1 diabetes, there was also no significant difference in A1C (0.69% (-0.31 to 1.68), P = 0.18). CONCLUSIONS. There was insufficient evidence that HP infection worsened glycemic control in patients with diabetes.

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  • Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes 査読

    Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Tomoko Ishizu, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hirohito Sone, Hitoshi Shimano

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   21 ( 8 )   799 - 815   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN ATHEROSCLEROSIS SOC  

    Aims: To compare the efficacy of Framingham Risk Score (FRS), UK Prospective Diabetes Study (UKPDS) risk engine, a risk score based on the Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC), the maximum intima-media thickness (max-IMT) determined on coronary computed tomography angiography (CCTA) and their combination in asymptomatic patients with type 2 diabetes.
    Methods: A total of 116 Japanese patients with type 2 diabetes underwent CCTA. The risk of coronary heart disease was calculated according to the FRS, UKPDS and JALS-ECC. We evaluated the reclassification of coronary artery stenosis (CAS) based on the risk score categories after adding each IMT related variable.
    Results: Sixty-eight patients had CAS. The areas under the curves (AUCs) in the receiver operating characteristic curve analyses of FRS, UKPDS and JALS-ECC were 0.763 (95% confidence interval [CI]: 0.674-0.853), 0.785 (95% CI: 0.703-0.868) and 0.767 (95% CI: 0.681-0.853), respectively. The AUCs for FRS, UKPDS and JALS-ECC combined with the max-IMT were 0.788 (95% CI: 0.705-0.872), 0.800 (95% CI: 0.720-0.879) and 0.786 (95% CI: 0.703-0.869), respectively. Combining the max-IMT with the risk scores improved the identification of subjects with stenotic lesions, in particular, those in the first, second and third tertiles of the FRS, first and second tertiles of the UKPDS and first and second tertiles of the JALS-ECC (P=0.054, P=0.056, P=0.015, P=0.082, P=0.060, P=0.007, and P=0.080, respectively). The net reclassification improvement increased following the addition of a max-IMT of &gt;= 1.9 mm (32.4% in FRS, 19.9% in UKPDS and 51.7% in JALS-ECC).
    Conclusions: These data suggest that combining a risk score with the max-IMT improves the prediction of CAS in comparison with the risk score alone.

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  • Changes in Fatty Acid Composition of Maiwashi (Sardine) Added with Linoleic Acid during Fermentation Process in Fish Sauce Making. 査読

    Akiyama Sannomaru Y, Sanceda N, Sone Y, Kurata T, Suzuki E

    Journal of Cookery Science of Japan. 47(3):165-170.   2014年

  • Effect of postmenopausal status and age at menopause on type 2 diabetes and prediabetes in Japanese individuals: Toranomon Hospital Health Management Center study 17 (TOPICS 17) 査読

    Yoriko Heianza, Yasuji Arase, Satoru Kodama, Shiun Dong Hsieh, Hiroshi Tsuji, Kazumi Saito, Hitoshi Shimano, Shigeko Hara, Hirohito Sone

    Diabetes Care   36 ( 12 )   4007 - 4014   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective-Findings on the effect of menopause or age at menopause on the presence of hyperglycemia are controversial, and why women after menopause have a higher probability of having hyperglycemia than men in the same age range remains unknown. Research design and methods-We reviewed data on 29,189 men, 6,308 premenopausalwomen, and 4,570 postmenopausal women in Japan. Odds ratios (ORs) for diabetes or prediabetes indicated by American Diabetes Association criteria were calculated for men and for pre- and postmenopausal women. Results-Compared with premenopausal women, women after natural menopause had an age-adjusted OR of 1.40 (95% CI 1.03-1.89) for diabetes, and women after menopause by surgical or other causes had an age-adjusted OR of 1.59 (1.07-2.37). The age-adjusted OR in men was 4.02 (3.15-5.14). Compared with premenopausal nondiabetic women, postmenopausal nondiabetic women had a significantly elevated OR of 1.33 (1.20-1.48) for prediabetes
    nondiabetic men had an OR of 1.93 (1.77-2.10) independently of age and demographic and metabolic factors. Even among women aged &lt
    50 years, postmenopausal status was significantly associated with an elevated OR (1.50 [1.18-1.91]) for dysglycemia (either diabetes or prediabetes). Postmenopausal women aged ≥50 years had a particularly elevated OR for dysglycemia, regardless of age at menopause. Conclusions-The postmenopausal state was significantly associated with the presence of dysglycemia independently of normal aging, although the increased probability in postmenopausal women did not equal that in men. Among women, menopause and older age might additively influence the elevated probability of dysglycemia. © 2013 by the American Diabetes Association.

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  • Quality and accuracy of Internet information concerning a healthy diet 査読

    Reiko Hirasawa, Yoko Yachi, Sakiko Yoshizawa, Chika Horikawa, Yoriko Heianza, Ayumi Sugawara, Yasuko Sone, Kazuo Kondo, Hitoshi Shimano, Kazumi Saito, Satoru Kodama, Hirohito Sone

    INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION   64 ( 8 )   1007 - 1013   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INFORMA HEALTHCARE  

    The Internet is used by many consumers interested in healthy living. The aim of the present study was to explore the variations among Internet information concerning a healthy diet and to evaluate the potential for misleading information. To conduct a descriptive analysis, the search term "healthy diet'' was entered into three search engines and the first 100 results were examined. Of the evaluated 48 websites, 5, 26 and 11, respectively, gave references, date when information was updated and cautioned users. For assessment of accuracy, six dietary guidelines were used as references and the website was scored according to the number of recommended dietary features that matched the guidelines. Websites that specified their objectives scored significantly higher when matched with each guideline than the websites that did not state four guidelines (p&lt;0.05). Internet information on a "healthy diet'' was likely to only partially follow recommendations of the guidelines.

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  • Use of high-normal levels of haemoglobin A(1C) and fasting plasma glucose for diabetes screening and for prediction: a meta-analysis. 査読 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Reiko Hirasawa, Yoko Yachi, Sakiko Yoshizawa, Shiro Tanaka, Yasuko Sone, Hitoshi Shimano, Kaoruko Tada Iida, Kazumi Saito, Hirohito Sone

    Diabetes/metabolism research and reviews   29 ( 8 )   680 - 92   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Using high-normal levels of haemoglobin A1C (Abnormal-A1C ) or fasting plasma glucose (FPG) (Abnormal-FPG) for diabetes screening are expected to improve the ability to detect persons with or at high risk of diabetes. We assessed the diagnostic and predictive capacity for diabetes of Abnormal-A1C and Abnormal-FPG. We compared these to the combined use of the two measures to the single use of either measurement. METHODS: We analysed 31 eligible cross-sectional or cohort studies that assessed diagnostic or predictive ability, respectively, by using lower A1C and FPG cutoff values than recommended by current diabetes criteria. Positive and negative likelihood ratios (LR+ and LR-) were calculated to assess the ability to confirm or exclude diabetes, respectively, on the basis of a bivariate random-effects model. RESULTS: With both Abnormal-A1C and Abnormal-FPG, the pooled LR+ was above 4 for diagnosing diabetes and above 3 for predicting diabetes. However, the pooled LR- for predicting diabetes was higher with Abnormal-A1C (0.48) and Abnormal-FPG (0.49) in comparison with that for diagnosing diabetes (0.27, Abnormal-A1C ; 0.28, Abnormal-FPG). In eight studies that assessed the predictive ability of the combination of A1C and FPG, using either Abnormal-A1C or Abnormal-FPG could lower LR- to 0.17 from 0.43 for only Abnormal-A1C and from 0.38 for only Abnormal-FPG. Accordingly, LR+ was also lowered to 2.37 from 3.36 for only Abnormal-A1C and from 3.84 for only-Abnormal-FPG. CONCLUSION: The use of the two blood glucose tests had insufficient capacity to identify subjects at high risk for diabetes but had considerable capacity to identify undiagnosed diabetes.

    DOI: 10.1002/dmrr.2445

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  • Erratum: HbA<inf>1c</inf> variability and the development of microalbuminuria in type 2 diabetes (Tsukuba Kawai Diabetes Registry 2)

    A. Sugawara, K. Kawai, S. Motohashi, K. Saito, S. Kodama, Y. Yachi, R. Hirasawa, H. Shimano, K. Yamazaki, H. Sone

    Diabetologia   56 ( 11 )   2548   2013年11月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00125-013-3042-6

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  • Association of living alone with the presence of undiagnosed diabetes in Japanese men: The role of modifiable risk factors for diabetes: Toranomon hospital health management center study 13 (TOPICS 13) 査読

    Y. Heianza, Y. Arase, S. Kodama, S. D. Hsieh, H. Tsuji, K. Saito, H. Shimano, S. Hara, H. Sone

    Diabetic Medicine   30 ( 11 )   1355 - 1359   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims: To investigate whether living alone was associated with the presence of undiagnosed diabetes and whether this association could be attenuated by modifiable lifestyle habits. Methods: This cross-sectional study included 6400 Japanese men without a history of diagnosed diabetes. Individuals with currently undiagnosed diabetes were identified through fasting glucose concentration ≥7.0 mmol/l or HbA1c concentration ≥ 48 mmol/mol (≥ 6.5%). Effect modification was examined using body mass index, hypertension, history of dyslipidaemia, drinking habits, smoking habits, physical activity, vegetable intake, emotional stress and depressed mood. Results: Men who lived alone (n = 1098) had a significantly elevated odds ratio for having undiagnosed diabetes in an age-adjusted model (odds ratio 1.45, 95% CI 1.07, 1.96
    P = 0.018). After adjustment for lifestyle factors, the association was slightly attenuated (odds ratio 1.40, 95% CI 1.02, 1.91
    P = 0.036). After further adjustment for all factors mentioned above, living alone was still marginally significantly associated with the presence of undiagnosed diabetes (odds ratio 1.38, 95% CI 1.003, 1.90
    P = 0.048). A significant association of living alone with the presence of undetected diabetes was particularly observed among men who were overweight, currently smoked and were physically inactive, or had any one of those three factors. Conclusions: The association between undiagnosed diabetes and living alone can be partially influenced by modifiable lifestyle factors. Men who lived alone, especially those who did not engage in favourable lifestyle habits, were more likely to have undiagnosed diabetes. Such individuals have a higher probability of having undetected diabetic hyperglycaemia and would need to undergo glucose tests to identify the disease. © 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.

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  • Body weight change and type 2 diabetes. 査読 国際誌

    Satoru Kodama, Chika Horikawa, Sakiko Yoshizawa, Kazuya Fujihara, Yoko Yachi, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Hiroaki Yagyu, Hirohito Sone

    Epidemiology (Cambridge, Mass.)   24 ( 5 )   778 - 9   2013年9月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1097/EDE.0b013e31829f6c31

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  • Genetic Variants of the Fatty Acid Desaturase Gene Cluster Are Associated with Plasma LDL Cholesterol Levels in Japanese Males 査読

    Yasuko Sone, Toshimi Kido, Tomomi Ainuki, Mariko Sonoda, Ikuyo Ichi, Satoru Kodama, Hirohito Sone, Kazuo Kondo, Yutaka Morita, Shigenobu Egawa, Kazuo Kawahara, Yuzuru Otsuka, Yoko Fujiwara

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY   59 ( 4 )   325 - 335   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CENTER ACADEMIC PUBL JAPAN  

    Fatty acid (FA) compositions in tissues are related to metabolic disorders, and consequently the appropriate management of underlying FA compositions in tissues is considered to be important. However, the relationship among the serum lipid profiles, the FA composition of the red blood cell (RBC) membranes and genetic variations in the fatty acid desaturase (FADS) genes in Japanese men is unclear. In this study, the subjects recruited were 137 Japanese men, 40 to 60 y old, who had a regular health checkup. Their serum lipid profile and the relative FA composition of the RBC membranes were measured. They were genotyped for the single nucleotide polymorphisms (SNPs) rs174553, rs174546, rs99780 and rs174583 in FADS gene. Multiple regression analysis was conducted to detect the relationship among hyperlipidemia, the FA composition of the RBC and the FADS genotypes. As a result, the homozygous genotype for the minor alleles in rs174553, rs174546, rs99780 were found to be associated with lower low-density lipoprotein cholesterol (LDL-C) levels and a lower LDL-C/total-cholesterol ratio. The homozygous genotype for the minor alleles reduced the risk of high LDL-C level (R-2=0.50, beta=-0.20, p=0.009), whereas, the arachidonic acid (AA) levels in the carriers of the homozygous genotype for the minor alleles tended to be lower compared with the carriers of the major alleles. However, no significant differences were observed in any FA level among the three genotypes for four SNPs. These results indicate that the appropriate management of serum LDL-C levels depending on genetic predisposition in FADS genotypes should be encouraged.

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  • Leisure-time physical activity is a significant predictor of stroke and total mortality in Japanese patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS) 査読

    H. Sone, S. Tanaka, S. Tanaka, S. Suzuki, H. Seino, O. Hanyu, A. Sato, T. Toyonaga, K. Okita, S. Ishibashi, S. Kodama, Y. Akanuma, N. Yamada

    Diabetologia   56 ( 5 )   1021 - 1030   2013年5月

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  • Two authors reply 査読

    Satoru Kodama, Hirohito Sone

    American Journal of Epidemiology   177 ( 8 )   863   2013年4月

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  • Role of alcohol drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS 11) 査読

    Yoriko Heianza, Yasuji Arase, Kazumi Saito, Hiroshi Tsuji, Kazuya Fujihara, Shiun Dong Hsieh, Satoru Kodama, Hitoshi Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

    AMERICAN JOURNAL OF CLINICAL NUTRITION   97 ( 3 )   561 - 568   2013年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER SOC NUTRITION-ASN  

    Background: Findings of past studies on the effect of drinking patterns on diabetes risk have been inconsistent.
    Objective: We aimed to investigate the role of drinking frequency and usual quantity consumed in the development of type 2 diabetes.
    Design: Enrolled were 1650 Japanese men without diabetes (diabetes: fasting plasma glucose &gt;= 7.0 mmol/L, glycated hemoglobin &gt;= 6.5%, or self-reported clinician-diagnosed diabetes). Average alcohol consumption and 12 combinations of frequency and usual quantity per drinking occasion were assessed at the baseline examination. The absolute risk and HR for the development of diabetes were calculated.
    Results: During a mean follow-up period of 10.2 y, 216 individuals developed diabetes. Lifetime abstainers (n = 153) had a relatively low incidence of diabetes (9.1/1000 person-years), similar to moderate consumers (99-160 g ethanol/wk; 9.0/1000 person-years). Increasingly higher quantities of alcohol usually consumed per occasion increased the risk of diabetes regardless of drinking frequency. The lowest incidence rate of diabetes (8.5/1000 person-years) was associated with the consumption of &lt;1 drink (&lt;23 g ethanol) per occasion over &gt;= 6 times/wk. Binge drinking (&gt;= 3 drinks per occasion) significantly increased the risk of future diabetes regardless of frequency (HR: 1.79; 95% CI: 1.17, 2.74) compared with &lt;1 drink per occasion.
    Conclusions: Among current drinkers, a drinking pattern of &lt;1 drink per occasion regularly over 6 times within a week was associated with the lowest risk of developing diabetes. Usual quantity per drinking occasion was a more important determinant than was weekly drinking frequency in the association between alcohol consumption and risk of diabetes in Japanese men. Am J Clin Nutr 2013;97:561-8.

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  • Effect of low-intensity focused ultrasound on the middle ear in a mouse model of acute otitis media. 査読

    Noda K, Hirano T, Noda K, Kodama S, Ichimiya I, Suzuki M

    Ultrasound in medicine & biology   39 ( 3 )   413 - 423   2013年3月

  • Development of a Screening Score for Undiagnosed Diabetes and Its Application in Estimating Absolute Risk of Future Type 2 Diabetes in Japan: Toranomon Hospital Health Management Center Study 10 (TOPICS 10) 査読

    Yoriko Heianza, Yasuji Arase, Kazumi Saito, Shiun Dong Hsieh, Hiroshi Tsuji, Satoru Kodama, Shiro Tanaka, Yasuo Ohashi, Hitoshi Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   98 ( 3 )   1051 - 1060   2013年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ENDOCRINE SOC  

    Objective: The objective of the study was to develop a screening score for undiagnosed diabetes by eliciting information on noninvasive clinical markers and to assess its effectiveness for identifying the presence of diabetes and predicting future diabetes.
    Design, Setting, and Participants: A screening score was cross-sectionally developed for 33 335 Japanese individuals aged 18-88 years without known diabetes who underwent a health examination. We validated its utility and compared it with existing screening tools in an independent population (n = 7477). After initial assessment of the instrument, 7332 nondiabetic individuals were followed up for a mean 4.0 years.
    Results: Prevalence of undiagnosed diabetes (fasting plasma glucose &gt;= 7.0 mmol/L or glycated hemoglobin &gt;= 6.5%) was 2.9% (n = 965). Diabetes score included age, sex, family history of diabetes, current smoking habit, body mass index, and hypertension with an area under the receiver-operating characteristics curve of 0.771. Screening with 8 or more points yielded a sensitivity of 72.7% and a specificity of 68.1%. In the validation cohort, the area under the receiver-operating characteristics curve was 0.806. The developed score with 8 or more points had better positive predictive value (9.6%) and positive likelihood ratio (2.52) compared with existing tools (positive predictive value, from 6.9% to 9.4%; positive likelihood ratio, from 1.77 to 2.46) in which each tool's highest combination of sensitivity and specificity was observed. The 4-year cumulative risk of developing diabetes gradually escalated in association with higher screening scores at the initial examination.
    Conclusions: Our algorism could serve as a self-assessment tool for undiagnosed diabetic patients needing timely medical care and as a prognostic tool for individuals without present diabetes who must be closely followed up to prevent future diabetes. (J Clin Endocrinol Metab 98: 1051-1060, 2013)

    DOI: 10.1210/jc.2012-3092

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  • [Effect of smoking on diabetes mellitus and dyslipidemia (effect of smoking on glucose and lipid metabolism)]. 査読

    Saito K, Sone H

    Nihon rinsho. Japanese journal of clinical medicine   71 ( 3 )   443 - 448   2013年3月

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  • Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes: a meta-analysis. 査読 国際誌

    Satoru Kodama, Shiro Tanaka, Yoriko Heianza, Kazuya Fujihara, Chika Horikawa, Hitoshi Shimano, Kazumi Saito, Nobuhiro Yamada, Yasuo Ohashi, Hirohito Sone

    Diabetes care   36 ( 2 )   471 - 9   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER DIABETES ASSOC  

    OBJECTIVE: The association between habitual physical activity (PA) and lowered risk of all-cause mortality (ACM) and cardiovascular disease (CVD) has been suggested in patients with diabetes. This meta-analysis summarizes the risk reduction in relation to PA, focusing on clarifying dose-response associations. RESEARCH DESIGN AND METHODS: Electronic literature searches were conducted for cohort studies that examined relative risk (RR) of ACM or CVD in relation to PA in patients with diabetes. For the qualitative assessment, RR for the highest versus the lowest PA category in each study was pooled with a random-effects model. We added linear and spline regression analyses to assess the quantitative relationship between increases in PA and ACM and CVD risk. RESULTS: There were 17 eligible studies. Qualitatively, the highest PA category had a lower RR [95% CI] for ACM (0.61 [0.52-0.70]) and CVD (0.71 [0.60-0.84]) than the lowest PA category. The linear regression model indicated a high goodness of fit for the risk of ACM (adjusted R(2) = 0.44, P = 0.001) and CVD (adjusted R(2) = 0.51, P = 0.001), with the result that a 1 MET-h/day incrementally higher PA was associated with 9.5% (5.0-13.8%) and 7.9% (4.3-11.4%) reductions in ACM and CVD risk, respectively. The spline regression model was not significantly different from the linear model in goodness of fit (P = 0.14 for ACM risk; P = 0.60 for CVD risk). CONCLUSIONS: More PA was associated with a larger reduction in future ACM and CVD risk in patients with diabetes. Nevertheless, any amount of habitual PA was better than inactivity.

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  • Diabetes and risk of hearing impairment in adults: a meta-analysis. 査読 国際誌

    Chika Horikawa, Satoru Kodama, Shiro Tanaka, Kazuya Fujihara, Reiko Hirasawa, Yoko Yachi, Hitoshi Shimano, Nobuhiro Yamada, Kazumi Saito, Hirohito Sone

    The Journal of clinical endocrinology and metabolism   98 ( 1 )   51 - 8   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ENDOCRINE SOC  

    CONTEXT: Recently, several studies have investigated the relationship between diabetes and hearing impairment, but results were inconsistent. OBJECTIVE: Our objective was to compare the prevalence of hearing impairment between diabetic and nondiabetic adults. DATA SOURCES: We performed a systematic literature search using MEDLINE (1950 to May 30, 2011) and EMBASE (1974 to May 30, 2011). STUDY SELECTION: Cross-sectional studies were included if data on numbers of hearing-impaired and non-hearing-impaired cases with diabetes were presented. Hearing impairment was limited to that assessed by pure-tone audiometry that included at least 2 kHz of frequency range and was defined as progressive, chronic, sensorineural, or without specified cause. DATA EXTRACTION: Two authors independently extracted relevant data. Odd ratios (ORs) of hearing impairment related to diabetes calculated in each study were pooled with the random-effects model. DATA SYNTHESIS: Data were obtained from 13 eligible studies (20,194 participants and 7,377 cases). Overall pooled OR (95% confidence interval) of hearing impairment for diabetic participants compared with nondiabetic participants was 2.15 (1.72-2.68). OR was higher in younger participants (mean age, ≤60 yr) than in those over 60 yr among which the OR remained significant (2.61 and 1.58, P = 0.008). The strength of the association between diabetes and prevalence of hearing impairment was not significantly influenced by whether participants were matched for age and gender (P = 0.68) or whether participants chronically exposed to noisy environments were excluded (P = 0.19). CONCLUSIONS: Current meta-analysis suggests that the higher prevalence of hearing impairment in diabetic patients compared with nondiabetic patients was consistent regardless of age.

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  • Low BMI at age 20 years predicts gestational diabetes independent of BMI in early pregnancy in Japan: Tanaka Women's Clinic Study. 国際誌

    Y Yachi, Y Tanaka, I Nishibata, A Sugawara, S Kodama, K Saito, H Sone

    Diabetic medicine : a journal of the British Diabetic Association   30 ( 1 )   70 - 3   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Maternal obesity and weight gain since early adulthood are known predictors of gestational diabetes in Western countries. However, their impact has not been evaluated well in Asia, where mean BMI levels are generally lower than in Western countries. We therefore examined the associations of BMI at age 20 years and BMI change since age 20 years with the risk of gestational diabetes in Japanese pregnant women. METHODS: Six hundred and twenty-four consecutive pregnant women without recognized diabetes before pregnancy, whose initial obstetric clinic visit was before 13 weeks' gestation, were prospectively observed. Weight at age 20 years was self-reported. Baseline height and weight measurements were obtained at the initial obstetric visit. Multivariate logistic regression analysis estimated the risk of incident gestational diabetes for BMI change since 20 years and BMI at age 20 years. RESULTS: Twenty-eight women developed incident gestational diabetes. By multivariate logistic regression analysis that adjusted for maternal age, parity and baseline BMI, we observed a statistically significant inverse association between BMI at age 20 years and incidence of gestational diabetes (odds ratio 0.68, 95% CI 0.51-0.92). Similarly, when we assessed the association of BMI change since age 20 years, adjusted for maternal age and parity, BMI change was associated with an increased risk of gestational diabetes (odds ratio 1.26, 95% CI 1.03-1.53). When we focused on the threshold of risk of gestational diabetes, women with BMI at 20 years of less than 18 kg/m(2) had a 6.30-fold (2.26-17.59) greater risk than women with both BMI at age 20 years of 18 kg/m(2) or more and BMI change since age 20 years of less than 1.85. CONCLUSIONS: Both low BMI at age 20 years and BMI change since age 20 years were significantly associated with increased risk of incident gestational diabetes.

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  • Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus 査読

    Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Nobuhiro Yamada, Hirohito Sone, Hitoshi Shimano

    Journal of Atherosclerosis and Thrombosis   20 ( 5 )   452 - 464   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims: To investigate the clinical predictors of coronary atherosclerosis and to assess the utility of maximum-IMT for predicting coronary atherosclerosis in asymptomatic type 2 diabetic patients. Methods: One hundred one Japanese patients with type 2 diabetes underwent computed tomography coronary angiography. Definitions of coronary artery stenosis and vulnerable coronary plaque were luminal narrowing of ≥50% and any coronary plaque with positive vessel remodeling and low attenuation, respectively. Carotid intima-media thickness (IMT) was assessed using B-mode ultrasound. Results: Of the 101 patients, 40 had coronary artery stenosis without vulnerable coronary plaque, 7 had vulnerable coronary plaque without coronary artery stenosis, and 23 had coronary artery stenosis with vulnerable coronary plaque. Male sex (p= 0.031), duration of diabetes (p= 0.024), systolic blood pressure (SBP) (p=0.039), and the LDL/HDL ratio (LDL/HDL) (p=0.013) were independent predictors of coronary artery stenosis and the LDL/HDL (p=0.042) independently predicted vulnerable coronary plaque by logistic regression analyses. Areas under the curves in receiver operating characteristic curve analysis of the maximum-IMT, LDL/HDL, and these two parameters combined were 0.711 (95% CI 0.601-0.820), 0.618 (0.508-0.728), and 0.732 (0.632-0.831), respectively, for predicting coronary artery stenosis and 0.655 (0.537-0.773), 0.629 (0.504-0.754), and 0.710 (0.601- 0.818), respectively, for predicting vulnerable coronary plaque. Conclusions: Male sex, duration of diabetes, elevated SBP, and LDL/HDL were independent predictors of coronary artery stenosis. LDL/HDL was an independent predictor of vulnerable coronary plaque. Maximum-IMT predicted both coronary stenosis and vulnerable coronary plaque. Adding LDL/HDL improved the prediction of coronary artery stenosis and vulnerable coronary plaque.

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  • The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome: A Meta-Analysis. 査読 国際誌

    Kazuya Fujihara, Satoru Kodama, Chika Horikawa, Sakiko Yoshizawa, Ayumi Sugawara, Reiko Hirasawa, Hitoshi Shimano, Yoko Yachi, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

    Sleep disorders   2013   150371 - 150371   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims. High prevalence of sleep apnea syndrome (SAS) has been reported in patients with diabetes. However, whether diabetic neuropathy (DN) contributes to this high prevalence is controversial. Our aim of this study is to compare the prevalence of SAS between patients with and without DN. Methods. Systematic literature searches were conducted for cross-sectional studies that reported the number of patients with DN and SAS using MEDLINE (from 1966 to Nov 5, 2012) and EMBASE (from 1974 to Nov 5, 2012). Odds ratios (ORs) of SAS related to DN were pooled with the Mantel-Haenszel method. Results. Data were obtained from 5 eligible studies (including 6 data sets, 880 participants, and 429 cases). Overall, the pooled OR of SAS in patients with DN compared with that in non-DN patients was significant (OR (95% CI), -1.95 (1.03-3.70)). The pooled OR of SAS was 1.90 (0.97-3.71) in patients with type 2 diabetes. Excluding data on patients with type 1 diabetes, a higher OR was observed in younger patients (mean age <60 years) than in those ≥60 years among whom the OR remained significant (3.82; 95% CI, 2.24-6.51 and 1.17; 95% CI, 0.81-1.68). Conclusions. Current meta-analysis suggested the association of some elements of neuropathy with SAS in type 2 diabetes. Further investigations are needed to clarify whether the association is also true for patients with type 1 diabetes.

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  • Comparisons of the strength of associations with future type 2 diabetes risk among anthropometric obesity indicators, including waist-to-height ratio: a meta-analysis. 査読 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Yoriko Heianza, Reiko Hirasawa, Yoko Yachi, Ayumi Sugawara, Shiro Tanaka, Hitoshi Shimano, Kaoruko Tada Iida, Kazumi Saito, Hirohito Sone

    American journal of epidemiology   176 ( 11 )   959 - 69   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    The aim of this meta-analysis was to compare the association of waist-to-height ratio (WHtR) with risk of incident diabetes with the associations of 3 other conventional obesity indicators (body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR)) with risk of incident diabetes. Literature searches in MEDLINE (January 1950 to April 27, 2011) and EMBASE (January 1974 to April 27, 2011) were conducted for prospective studies that made it possible to estimate the relative risk of diabetes per 1-standard deviation increase in WHtR, in addition to the RR of BMI, WC, or WHR. Strength of the estimated pooled relative risk for a 1-standard deviation increase of each indicator (expressed as RR(WHtR), RR(BMI), RR(WC), and RR(WHR)) was compared with a bivariate random-effects model. Pooled relative risks of the 15 eligible studies with 6,472 diabetes cases were 1.62 (95% CI: 1.48, 1.78) for RR(WHtR), 1.55 (95% CI: 1.43, 1.69) for RR(BMI), 1.63 (95% CI: 1.49, 1.79) for RR(WC), and 1.52 (95% CI: 1.40, 1.66) for RR(WHR). WHtR had an association stronger than that of BMI (P<0.001) or WHR (P<0.001). The present meta-analysis showed that WHtR has a modestly but statistically greater importance than BMI and WHR in prediction of diabetes. Nevertheless, measuring height in addition to WC appeared to have no additional benefit.

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  • Development of a new scoring system for predicting the 5 year incidence of type 2 diabetes in Japan: the Toranomon Hospital Health Management Center Study 6 (TOPICS 6) 査読

    Y. Heianza, Y. Arase, S.D. Hsieh, K. Saito, H. Tsuji, S. Kodama, S. Tanaka, Y. Ohashi, H. Shimano, N. Yamada, S. Hara, H. Sone

    Diabetologia   55 ( 12 )   3213 - 3223   2012年12月

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  • Development of Coronary Heart Disease and Cerebral Stroke in Japanese Elderly Patients with Nonalcoholic Fatty Liver Diseases

    Kyoko Ogawa, Yuki Ohmoto-Sekine, Shigeko Hara, Chikao Okuda, Kazuhisa Amakawa, Satao Arimoto, Hisahito Kato, Shiun Dong Hsieh, Maho Tanabe, Chie Ogata, Makiko Ishihara, Hiroshi Tsuji, Kazumi Saito, Satoru Kodama, Hirohito Sone, Yasuji Arase

    人間ドック = Ningen dock : official journal of the Japanese Society of Human Dry Dock   27 ( 3 )   561 - 567   2012年9月

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    記述言語:英語   出版者・発行元:Japan Society of Ningen Dock  

    <b>Objective: </b>Metabolic syndrome enhances coronary heart disease and cerebral stroke. However, few longitudinal studies have been conducted on the incidence of coronary heart disease and cerebral stroke in Japanese patients with non-alcoholic fatty liver disease (NAFLD) and the risk factors for its development. <br><b>Methods: </b>A total of 1,798 NAFLD patients with an age of ≥60 years were enrolled. The primary event was the first onset of coronary heart disease or cerebral stroke. Independent factors associated with the incidence rate of such events were analyzed by the Kaplan-Meyer method and the Cox proportional hazard model. The mean observation period was 7.5 years.<br><b>Results: </b>The number of cases of coronary heart disease or cerebral stroke that developed was 137. The 10th year cumulative development rate was 11.7% in the NAFLD patients. Cox proportional hazards analysis revealed the following: 1) Coronary heart disease occurred with statistical significance when patients had poor control of blood pressure, smoking, low high density lipoprotein level, and high glucose level. 2) Ischemic stroke occurred with statistical significance when patients had poor control of blood pressure, an age of ≥70 years, and high glucose level. 3) Hemorrhagic stroke occurred with statistical significance when patients had poor control of blood pressure, age ≥70 years, low albumin level of <3.9 g/dL and high aspartate aminotransferase to platelet ratio index. <br><b>Conclusion: </b>Our study indicates that the risk factors for the development of vascular disease are different for coronary heart disease, ischemic stroke and hemorrhagic stroke in Japanese elderly patients with NAFLD.

    DOI: 10.11320/ningendock.27.561

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  • Low Lung Function and Risk of Type 2 Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study 9 (TOPICS 9) 査読

    Yoriko Heianza, Yasuji Arase, Hiroshi Tsuji, Kazumi Saito, Kazuhisa Amakawa, Shiun Dong Hsieh, Satoru Kodama, Hitoshi Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

    MAYO CLINIC PROCEEDINGS   87 ( 9 )   853 - 861   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Objective: To evaluate the effect of elevated fasting plasma glucose (FPG) and hemoglobin A(1c) (HbA(1c)) concentrations on lung dysfunction and to prospectively investigate whether reduced lung function would be independently predictive of diabetes.
    Participants and Methods: From January 6, 1997, through December 22, 2008, we observed 5346 men with no history of diabetes or lung dysfunction. Hazard ratios (HRs) for incident diabetes (FPG &gt;= 126 mg/dL, HbA(1c)&gt;= 6.5%, or self-reported clinician-diagnosed diabetes) were estimated for spirometry indices as continuous and categorical variables.
    Results: Elevated HbA(1c) concentrations within the normal range were significantly and more strongly associated with reduced forced vital capacity and forced expiratory volume in the first second after expiration (FEV1) than were FPG concentrations. During a 4.0-year follow-up, diabetes developed in 214 individuals. A 10-point decrease in percentage of FEV1 predicted value was associated with an increased HR of 1.21 (95% confidence interval [CI], 1.09-1.34; P=.001) for diabetes after adjustment for demographic factors and body mass index. This association remained significant even after adjustment for metabolic factors, smoking status, and FPG or HbA(1c) concentrations but was attenuated substantially after adjustment for baseline HbA(1c) values (HR, 1.13; 95% CI, 1.01-1.26; P=.03). Lower quartile (Q) categories of percentage of FEV1 predicted value were associated with increased risk of diabetes independently of known predictors including HbA(1c) (HR, 1.73; 95% CI, 1.14-2.62 for Q1; and HR, 1.76; 95% CI, 1.15-2.69 for Q2).
    Conclusion: Reduced lung function was significantly related to chronic glycemic exposure within a normal range. Relatively low pulmonary function was an independent risk factor for diabetes in apparently healthy Japanese men. (C) 2012 Mayo Foundation for Medical Education and Research square Mayo Clin Proc. 2012:87(9);853-861

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  • Screening for pre-diabetes to predict future diabetes using various cut-off points for HbA1c and impaired fasting glucose: the Toranomon Hospital Health Management Center Study 4 (TOPICS 4)

    Heianza, Y, Arase, Y, Fujihara, K, Tsuji, H, Saito, K, Hsieh, S. D, Kodama, S, Shimano, H, Yamada, N, Hara, S, Sone, H

    DIABETIC MEDICINE   29 ( 9 )   E279 - E285   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

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  • HbA(1c) variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2 査読

    A. Sugawara, K. Kawai, S. Motohashi, K. Saito, S. Kodama, Y. Yachi, R. Hirasawa, H. Shimano, K. Yamazaki, H. Sone

    DIABETOLOGIA   55 ( 8 )   2128 - 2131   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The aim of this study was to examine the association between HbA(1c) variability and the development of microalbuminuria as defined by an albumin/creatinine ratio a parts per thousand yen3.4 mg/mmol (a parts per thousand yen30 mg/g) in at least two of three consecutive urine samples in Japanese patients with type 2 diabetes.
    HbA(1c) level was measured in 812 serially registered normoalbuminuric adults aged 21-79 years with type 2 diabetes. After registration, a 1-year period to establish baseline values for mean HbA(1c) and HbA(1c) variability (measured as the intrapersonal SD of serially collected HbA(1c)) was decided upon. The association between HbA(1c) variability and the development of microalbuminuria was determined by Cox regression analysis after adjustment for other risk factors for microalbuminuria.
    Microalbuminuria occurred in 193 patients during the observation period of (mean +/- SD) 4.3 +/- 2.7 years. Even after adjustment for mean HbA(1c), HbA(1c) variability was a significant predictor of microalbuminuria independently of the mean HbA(1c); the HR for every 1% (95% CI) increase in mean HbA(1c) was 1.22 (1.06, 1.40) (p = 0.005), and that for HbA(1c) variability was 1.35 (1.05, 1.72) (p = 0.019). The effects of these two variables were quite similar when 1 SD was used; the HR for every 1 SD increase (95% CI) in HbA(1c) was 1.23 (1.07, 1.43) (p = 0.005), and that for HbA(1c) variability was 1.20 (1.03, 1.39) (p = 0.019).
    HbA(1c) variability affects the development of microalbuminuria independently of mean HbA(1c) in type 2 diabetes. Further studies should be performed to evaluate the influence of HbA(1c) variability on other complications and in individuals of other ethnicities with type 2 diabetes.

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  • Effect of Web-based Lifestyle Modification on Weight Control: A Meta-analysis. 査読 国際誌

    Kodama S, Saito K, Tanaka S, Horikawa C, Fujiwara K, Hirasawa R, Yachi Y, Iida KT, Shimano H, Ohashi Y, Yamada N, Sone H

    International journal of obesity   36 ( 5 )   675 - 685   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/ijo.2011.121

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  • Longitudinal Trajectories of HbA(1c) and Fasting Plasma Glucose Levels During the Development of Type 2 Diabetes The Toranomon Hospital Health Management Center Study 7 (TOPICS 7) 査読

    Yoriko Heianza, Yasuji Arase, Kazuya Fujhara, Shiun Dung Hsieh, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Naoya Yahagi, Hitosh Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

    DIABETES CARE   35 ( 5 )   1050 - 1052   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER DIABETES ASSOC  

    OBJECTIVE-To describe the trajectory of HbA(1c), and glucose concentrations before the diagnosis of diabetes.
    RESEARCH DESIGN AND METHODS-The study comprised 1,722 nondiabetic Japanese individuals aged 26-80 years. Fasting plasma glucose (FPG) and HbA(1c) were measured annually for a mean of 9.5 (SD 1.8) years.
    RESULTS-Diabetes occurred in 193 individuals (FPG &gt;= 7.0 mmol/L, self-reported clinician-diagnosed diabetes, or HbA(1c) &gt;= 6.5%). Mean HbA(1c) values were &gt;5.6% each year before diagnosis in diabetes cases. Mean HbA(1c) (5.69% [95% CI 5.50-5.88]) was higher in the 21 individuals who developed diabetes 10 years after the baseline examination than in nondiabetic individuals after 10 years (5.27% [5.25-5.28]). From 3 years to 1 year prediagriosis, HbA(1c) increased 0.09% (SE 0.01)/year, reaching 5.90% (5.84-5.96) 1 year prediagnosis. In the entire group, marked increases in HbA(1c) of 0.3% (SE 0.05%)/year and FPG of 0.63 (0.07) mmol/L/year predicted diabetes.
    CONCLUSIONS HbA(1c) trajectory increased sharply after gradual long-term increases in diabetic individuals.

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  • Quality of Internet information related to the Mediterranean diet 査読

    Reiko Hirasawa, Kazumi Saito, Yoko Yachi, Yoko Ibe, Satoru Kodama, Mihoko Asumi, Chika Horikawa, Aki Saito, Yoriko Heianza, Kazuo Kondo, Hitoshi Shimano, Hirohito Sone

    PUBLIC HEALTH NUTRITION   15 ( 5 )   885 - 893   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CAMBRIDGE UNIV PRESS  

    Objective: The present study aimed to evaluate the quality of Internet information on the Mediterranean diet and to determine the relationship between the quality of information and the website source.
    Design: Website sources were categorized as institutional, pharmaceutical, non-pharmaceutical commercial, charitable, support and alternative medicine. Content quality was evaluated using the DISCERN rating instrument, the Health On the Net Foundation's (HON) code principles, and Journal of the American Medical Association (JAMA) benchmarks. Readability was graded by the Flesch Reading Ease score and Flesch-Kincaid Grade Level score.
    Setting: The phrase 'Mediterranean diet' was entered as a search term into the six most commonly used English-language search engines.
    Subjects: The first thirty websites forthcoming by each engine were examined.
    Results: Of the 180 websites identified, thirty-two met our inclusion criteria. Distribution of the website sources was: institutional, n 8 (25 %); non-pharmaceutical commercial, n 12 (38 %); and support, n 12 (38 %). As evaluated by the DISCERN, thirty-one of the thirty-two websites were rated as fair to very poor. Non-pharmaceutical commercial sites scored significantly lower than institutional and support sites (P=0.002). The mean Flesch Reading Ease score and mean Flesch-Kincaid Grade Level were 55.9 (fairly difficult) and 7.2, respectively. The Flesch-Kincaid Grade Level score determines the difficulty of material by measuring the length of words and sentences and converting the results into a grade level ranging from 0 to 12 (US grade level).
    Conclusions: Due to the poor quality of website information on the Mediterranean diet, patients or consumers who are interested in the Mediterranean diet should get advice from physicians or dietitians.

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  • Impact of introducing HbA1c into the diagnostic criteria on prevalence and cardiovascular risk profiles of individuals with newly diagnosed diabetes in Japan: The Toranomon Hospital Health Management Center Study 2 (TOPICS 2) 査読

    Yoriko Heianza, Shigeko Hara, Yasuji Arase, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Shiun Dong Hsieh, Yasumichi Mori, Minoru Okubo, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

    DIABETES RESEARCH AND CLINICAL PRACTICE   95 ( 2 )   283 - 290   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: To evaluate the impact of HbA1c for diagnosis of diabetes and investigate whether cardiovascular risks profiles differ among individuals with diabetes diagnosed by HbA1c or fasting plasma glucose (FPG).
    Methods: This cross-sectional study involved 26,884 participants (30.6% women; aged 20-91 years) without known diabetes. Subjects were categorized into 4 groups according to the presence or absence of FPG &gt;= 7.0 mmol/L and/or HbA1c &gt;= 6.5%, which were American Diabetes Association criteria. Oral glucose tolerance test data were not available.
    Results: Prevalence of undiagnosed diabetes was 3.6%. Of those individuals, 47.5% fulfilled both two criteria and 26.0% fulfilled only HbA1c criterion. Individuals with diabetes according to FPG &gt;= 7.0 mmol/L alone were characterized as having poorly controlled hypertension while those with HbA1c &gt;6.5% alone were characterized as older, female, and having lower blood pressure and gamma-glutamyltransferase values. Persons with newly diagnosed diabetes by HbA1c had low HDL cholesterol and high LDL or non-HDL cholesterol levels.
    Conclusions: Introducing HbA1c into the diagnosis allowed detection of many previously undiagnosed cases of diabetes in Japanese individuals. Those diagnosed by FPG were characterized by hypertension and those diagnosed by HbA1c had unfavorable lipid profiles, reflecting an atherosclerotic trait. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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  • Fasting and Post-Challenge Glucose as Quantitative Cardiovascular Risk Factors: A Meta-Analysis 査読

    Kodama Satoru, Shimano Hitoshi, Ohashi Yasuo, Yamada Nobuhiro, Sone Hirohito, Saito Kazumi, Tanaka Shiro, Horikawa Chika, Fujiwara Kazuya, Hirasawa Reiko, Yachi Yoko, Sone Yasuko, Tada Iida Kaoruko

    Journal of Atherosclerosis and Thrombosis   19 ( 4 )   385 - 396   2012年

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    記述言語:英語   出版者・発行元:一般社団法人 日本動脈硬化学会  

    Aim: The post-challenge glucose (PCG) level has been suggested to be superior to the fasting blood glucose (FG) level for predicting the risk of future cardiovascular disease (CVD); however, the extent of its superiority has not been consistently shown among previous cohort studies. Therefore, we conducted a meta-analysis to summarize the quantitative association of FG and PCG with CVD risk and compared the strengths of the two associations.<BR>Method: Electronic literature searches using MEDLINE and EMBASE with an additional manual search were conducted for prospective observational studies of the association of FG and PCG with CVD risk. Studies were included if they were prospective studies in which the relative risk (RR) of CVD per 1 standard deviation increase in both FG and PCG could be estimated. Pooled relative risks for the incremental increase were calculated as RR<sub>FG</sub> and RR<sub>PCG</sub> using a bivariate random-effects model.<BR>Result: Data were obtained from 14 eligible studies that included 70,889 participants and 2,927 cases. The pooled RR<sub>FG</sub> and RR<sub>PCG</sub> (95% confidence interval) were, respectively, 1.15 (1.06 to 1.26) and 1.24 (1.12 to 1.36); the difference was significant (<i>P</i> =0.001). The association of PCG with CVD risk was stronger in studies that targeted participants with a baseline mean FG < 100 mg/dl (<i>P</i> < 0.001) or mean age &ge; 55 years (<i>P</i> =0.004).<BR>Conclusions: Overall, the association of PCG with CVD risk was stronger than that of FG by approximately 50% on a log scale. Measuring PCG is especially important in populations with relatively low FG levels or in the elderly, although it is often burdensome in routine clinical practice.

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  • Impact of psychological stress caused by the Great East Japan Earthquake on glycemic control in patients with diabetes 査読

    K. Fujihara, A. Saito, Y. Heianza, H. Gibo, H. Suzuki, H. Shimano, K. Saito, S. Kodama, N. Yamada, H. Sone

    Experimental and Clinical Endocrinology and Diabetes   120 ( 9 )   560 - 563   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We examined the relationship between psychological stress and the worsening of glycemic control in diabetic patients at the time of the Great East Japan Earthquake. HbA1c levels in diabetic patients before and after the disaster were evaluated with the General Health Questionnaire (GHQ) and other questions including those on changes in diet, exercise, psychological stress and drug intake in 320 consecutive diabetic patients who had been followed in a diabetes clinic. Logistic regression analysis revealed that the total GHQ scores (odds ratio [OR] 1.03 [95% confidence interval 1.01-1.06]
    p&lt
    0.01) and interruption of drug intake (OR 4.48 [1.57-12.7]
    p=0.01) were independently associated with worsening of glycemic control defined as an increase in the HbA1c level equal to or greater than 0.5%. Among the scores on the GHQ, those for somatic symptoms (OR 1.18 [1.01-1.38]
    p=0.03) and sleep disturbances or anxiety (OR 1.26 [1.08-1.46]
    p&lt
    0.01) were independently associated with glycemic control. These results suggest that psychological stress during a disaster has independent effects on worsening of glycemic control. © Georg Thieme Verlag KG Stuttgart · New York.

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  • Self-reported fast eating is a potent predictor of development of impaired glucose tolerance in Japanese men and women: Tsukuba Medical Center Study 査読

    Kumiko Totsuka, Takami Maeno, Kazumi Saito, Satoru Kodama, Mihoko Asumi, Yoko Yachi, Yuri Hiranuma, Hitoshi Shimano, Nobuhiro Yamada, Yukio Ono, Takashi Naito, Hirohito Sone

    DIABETES RESEARCH AND CLINICAL PRACTICE   94 ( 3 )   E72 - E74   2011年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    We recorded self-reported eating patterns in 172 Japanese men and women who were subsequently followed for 3 years for the occurrence of impaired glucose tolerance (IGT).
    Incidence of IGT was significantly higher in those who reported eating fast. Self-reported eating fast is a potent risk factor for development of IGT. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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  • The Level of Orally Ingested Vitamin C Affected the Expression of Vitamin C Transporters and Vitamin C Accumulation in the Livers of ODS Rats 査読

    Yasuko Sone, Etsuko Ueta, Satoru Kodama, Yasuko Sannoumaru, Noriko Miyake, Hirohito Sone, Yoko Fujiwara, Yuzuru Otsuka, Kazuo Kondo, Masahiro Inagaki, Eiji Namba, Tadao Kurata, Emiko Suzuki

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   75 ( 12 )   2394 - 2397   2011年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    We investigated the effects of vitamin C administration on vitamin C-specific transporters in ODS/ShiJcl-od/od rat livers. The vitamin C-specific transporter levels increased in the livers of the rats not administered vitamin C and decreased in the livers of those administered vitamin C at 100 mg/d, indicating that these transporter levels can be influenced by the amount of vitamin C administered.

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  • [Endoscopic dacryocystorhinostomy with mucosal flap]. 査読

    Kodama S, Hirano T, Suzuki M

    Nihon Jibiinkoka Gakkai kaiho   114 ( 10 )   820 - 823   2011年10月

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    出版者・発行元:The Oto-Rhino-Laryngological Society of Japan, Inc.  

    近年, 内視鏡下の鼻内涙嚢鼻腔吻合術が行われるようになったが, 術者により手技が異なっている. われわれの手術の工夫について報告する.<br>鼻堤を基部としたaxillary flapを下方に延長した粘膜弁を作成し, 上顎骨前頭突起と涙骨を削開し, 涙嚢を露出させる. 涙嚢を工の字形になるように, 縦切開と上下に横切開を加え, 前後に翻転する. 開窓部の大きさに合わせて, 粘膜弁をトリミングし, 骨面を被覆し, シリコンシートによるステントを留置する.<br>われわれの方法では, 全周性に露出した骨面をすべて被うことができ, 十分な開窓を保つことが可能である. また眼窩側, 涙点側からの操作は不要であり, 耳鼻咽喉科単独で施行可能である.

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  • Skipping breakfast and prevalence of overweight and obesity in Asian and Pacific regions: a meta-analysis. 査読 国際誌

    Chika Horikawa, Satoru Kodama, Yoko Yachi, Yoriko Heianza, Reiko Hirasawa, Yoko Ibe, Kazumi Saito, Hitoshi Shimano, Nobuhiro Yamada, Hirohito Sone

    Preventive medicine   53 ( 4-5 )   260 - 7   2011年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    OBJECTIVE: In Western countries, skipping breakfast is associated with a high prevalence of overweight and obesity. This meta-analysis aimed to determine if the same relationship exists in Asian and Pacific regions. METHODS: A systematic literature search was performed for observational studies using a cross-sectional design that examined the relationship between frequency of eating breakfast and overweight or obesity. Odds ratios (ORs) for overweight or obesity were pooled with a variance-based method. RESULTS: Nineteen studies (93,108 total participants and 19,270 overweight or obese cases) were included. The pooled OR [95% confidence intervals (CI)] of overweight or obesity for the lowest vs. highest category of breakfast frequency was 1.75 [1.57 to 1.95] (P<0.001). Between-study heterogeneity in the association's strength was highly significant (I-squared=36.4%, P<0.001), although a positive OR was shown in all but one included study. However, no study characteristics could be identified to explain the heterogeneity. CONCLUSION: This meta-analysis suggests that a positive association between skipping breakfast and overweight and obesity is globally observed regardless of cultural diversity among countries. Promoting the eating of breakfast in all populations may be beneficial.

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  • Factors associated with inappropriate weight loss attempts by early adolescent girls in Japan

    A. Sugawara, M. Sato, K. Totsuka, K. Saito, S. Kodama, A. Fukushi, Y. Yamanashi, E. Matsushima, Y. Fujiwara, E. Suzuki, K. Kondo, S. Yamamoto, H. Sone

    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity   16 ( 3 )   e157 - e163   2011年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf03325127

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  • HbA1c 5·7-6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study. 査読

    Heianza Y, Hara S, Arase Y, Saito K, Fujiwara K, Tsuji H, Kodama S, Hsieh SD, Mori Y, Shimano H, Yamada N, Kosaka K, Sone H

    Lancet (London, England)   378 ( 9786 )   147 - 155   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 日本人2型糖尿病患者における大血管合併症の疫学

    曽根 博仁, 山田 信博, 赤沼 安夫

    糖尿病   54 ( 1 )   2 - 5   2011年1月

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    記述言語:日本語   出版者・発行元:THE JAPAN DIABETES SOCIETY  

    DOI: 10.11213/tonyobyo.54.2

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  • Alcohol consumption and risk of atrial fibrillation: a meta-analysis. 査読 国際誌

    Satoru Kodama, Kazumi Saito, Shiro Tanaka, Chika Horikawa, Aki Saito, Yoriko Heianza, Yui Anasako, Yukako Nishigaki, Yoko Yachi, Kaoruko Tada Iida, Yasuo Ohashi, Nobuhiro Yamada, Hirohito Sone

    Journal of the American College of Cardiology   57 ( 4 )   427 - 36   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    OBJECTIVES: The purpose of this meta-analysis is to summarize the estimated risk of atrial fibrillation (AF) related to alcohol consumption. BACKGROUND: Results from observational studies examining the relationship between alcohol consumption and AF are inconsistent. METHODS: A systematic electronic search of Medline (January 1966 to December 2009) and Embase (January 1974 to December 2009) databases was conducted for studies using key words related to alcohol and AF. Studies were included if data on effect measures for AF associated with habitual alcohol intake were reported or could be calculated. The effect measures for AF for the highest versus lowest alcohol intake in individual studies were pooled with a variance-based method. Linear and spline regression analyses were conducted to quantify the relationship between alcohol intake and AF risk. RESULTS: Fourteen eligible studies were included in this meta-analysis. The pooled estimate of AF for the highest versus the lowest alcohol intake was 1.51 (95% confidence interval: 1.31 to 1.74). A linear regression model showed that the pooled estimate for an increment of 10 g per day alcohol intake was 1.08 (95% confidence interval: 1.05 to 1.10; R(2) = 0.43, p < 0.001). A spline regression model also indicated that the AF risk increased with increasing levels of alcohol consumption. CONCLUSIONS: Results of this meta-analysis suggest that not consuming alcohol is most favorable in terms of AF risk reduction.

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  • Are serum cholesterol levels associated with silent brain infarcts? The Seiryo Clinic Study 査読

    Mihoko Asumi, Tatsuo Yamaguchi, Kazumi Saito, Satoru Kodama, Hidemitsu Miyazawa, Hiroshige Matsui, Emiko Suzuki, Hiroshi Fukuda, Hirohito Sone

    ATHEROSCLEROSIS   210 ( 2 )   674 - 677   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: High levels of serum cholesterol are associated with the risk of stroke. However, the association of serum cholesterol with silent brain infarcts (SBIs) is unclear. We investigated the association between SBI and various clinical factors.
    Methods: We conducted a cross-sectional study that included 324 apparently healthy Japanese men(mean age 53.8 +/- 9.2 years). Combinations of three types of scan (T1-weighted, T2-weighted and FLAIR images) were used to detect and discriminate SBI.
    Results: Serum cholesterol was significantly associated with SBI [total cholesterol, odds ratio (OR) 3.75 (95% confidence interval (CI) 1.45-9.68); LDL-cholesterol, OR 2.54 (95% CI 1.03-6.27), and non-HDL-cholesterol, OR 2.54 (95% CI 1.03-6.27)] after adjustment for age, smoking status, serum triglycerides, maximal-intima-media thickness, obesity, hypertension, diabetes mellitus, hyperuricemia, coronary heart disease and lipid-lowering agent use.
    Conclusion: Our cross-sectional data suggest that serum cholesterol levels are associated with SBI independently of known confounders. (c) 2010 Elsevier Ireland Ltd. All rights reserved.

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  • Comparison between Fasting and Post-Load Glucose Values as a Continuous Risk Factor for Cardiovascular Disease: A Meta-Analysis. 査読

    Kodama, S, Horikawa, C, Anasako, Y, Saito, K, Hirasawa, R, Ibe, Y, Yachi, Y, Asumi, M, Shimano, H, Yamada, N, Sone, H

    DIABETES   59 ( Suppl )   A298-A298   2010年6月

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  • Association between serum uric acid and development of type 2 diabetes. 査読 国際誌

    Satoru Kodama, Kazumi Saito, Yoko Yachi, Mihoko Asumi, Ayumi Sugawara, Kumiko Totsuka, Aki Saito, Hirohito Sone

    Diabetes care   32 ( 9 )   1737 - 42   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER DIABETES ASSOC  

    OBJECTIVE: To systematically evaluate the association between serum uric acid (SUA) level and subsequent development of type 2 diabetes. RESEARCH DESIGN AND METHODS: We searched Medline (31 March from 1966 to 2009) and Embase (31 March from 1980 to 2009) for observational cohort studies examining the association between SUA and the risk of type 2 diabetes by manual literature search. Relative risks (RRs) for each 1 mg/dl increase in SUA were pooled by using a random-effects model. The studies included were stratified into subgroups representing different study characteristics, and meta-regression analyses were performed to investigate the effect of these characteristics on the association between SUA level and type 2 diabetes risk. RESULTS: The search yielded 11 cohort studies (42,834 participants) that reported 3,305 incident cases of type 2 diabetes during follow-up periods ranging from 2.0 to 13.5 years. The pooled RR of a 1 mg/dl increase in SUA was 1.17 (95% CI 1.09-1.25). Study results were consistently significant (i.e., >1) across characteristics of participants and study design. Publication bias was both visually and statistically suggested (P = 0.03 for Egger's test, 0.06). Adjustment for publication bias attenuated the pooled RR per mg/dl increase in SUA (RR 1.11 [95% CI 1.03-1.20]), but the association remained statistically significant (P = 0.009). CONCLUSIONS: The current meta-analysis suggests that SUA level is positively associated with the development of type 2 diabetes regardless of various study characteristics. Further research should attempt to determine whether it is effective to utilize SUA level as a predictor of type 2 diabetes for its primary prevention.

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  • No Relationship Between Body Mass Index During Adolescence and All-Cause Mortality in Japanese Women-A 56.5-Year Observational Study 査読

    Mutsumi Sato, Satoru Kodama, Ayumi Sugawara, Kumiko Totsuka, Kazumi Saito, Hirohito Sone

    ANNALS OF EPIDEMIOLOGY   19 ( 8 )   590 - 591   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

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  • Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. 査読 国際誌

    Satoru Kodama, Kazumi Saito, Shiro Tanaka, Miho Maki, Yoko Yachi, Mihoko Asumi, Ayumi Sugawara, Kumiko Totsuka, Hitoshi Shimano, Yasuo Ohashi, Nobuhiro Yamada, Hirohito Sone

    JAMA   301 ( 19 )   2024 - 35   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER MEDICAL ASSOC  

    CONTEXT: Epidemiological studies have indicated an inverse association between cardiorespiratory fitness (CRF) and coronary heart disease (CHD) or all-cause mortality in healthy participants. OBJECTIVE: To define quantitative relationships between CRF and CHD events, cardiovascular disease (CVD) events, or all-cause mortality in healthy men and women. DATA SOURCES AND STUDY SELECTION: A systematic literature search was conducted for observational cohort studies using MEDLINE (1966 to December 31, 2008) and EMBASE (1980 to December 31, 2008). The Medical Subject Headings search terms used included exercise tolerance, exercise test, exercise/physiology, physical fitness, oxygen consumption, cardiovascular diseases, myocardial ischemia, mortality, mortalities, death, fatality, fatal, incidence, or morbidity. Studies reporting associations of baseline CRF with CHD events, CVD events, or all-cause mortality in healthy participants were included. DATA EXTRACTION: Two authors independently extracted relevant data. CRF was estimated as maximal aerobic capacity (MAC) expressed in metabolic equivalent (MET) units. Participants were categorized as low CRF (< 7.9 METs), intermediate CRF (7.9-10.8 METs), or high CRF (> or = 10.9 METs). CHD and CVD were combined into 1 outcome (CHD/CVD). Risk ratios (RRs) for a 1-MET higher level of MAC and for participants with lower vs higher CRF were calculated with a random-effects model. DATA SYNTHESIS: Data were obtained from 33 eligible studies (all-cause mortality, 102 980 participants and 6910 cases; CHD/CVD, 84 323 participants and 4485 cases). Pooled RRs of all-cause mortality and CHD/CVD events per 1-MET higher level of MAC (corresponding to 1-km/h higher running/jogging speed) were 0.87 (95% confidence interval [CI], 0.84-0.90) and 0.85 (95% CI, 0.82-0.88), respectively. Compared with participants with high CRF, those with low CRF had an RR for all-cause mortality of 1.70 (95% CI, 1.51-1.92; P < .001) and for CHD/CVD events of 1.56 (95% CI, 1.39-1.75; P < .001), adjusting for heterogeneity of study design. Compared with participants with intermediate CRF, those with low CRF had an RR for all-cause mortality of 1.40 (95% CI, 1.32-1.48; P < .001) and for CHD/CVD events of 1.47 (95% CI, 1.35-1.61; P < .001), adjusting for heterogeneity of study design. CONCLUSIONS: Better CRF was associated with lower risk of all-cause mortality and CHD/CVD. Participants with a MAC of 7.9 METs or more had substantially lower rates of all-cause mortality and CHD/CVD events compared with those with a MAC of less 7.9 METs.

    DOI: 10.1001/jama.2009.681

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  • Physical Fitness During Adolescence and Adult Mortality 査読

    Mutsumi Sato, Satoru Kodama, Ayumi Sugawara, Kazumi Saito, Hirohito Sone

    EPIDEMIOLOGY   20 ( 3 )   463 - 464   2009年5月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1097/EDE.0b013e31819ed09f

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  • Thinness in Japanese Young Women 査読

    Ayumi Sugawara, Kazumi Saito, Mutsumi Sato, Satoru Kodama, Hirohito Sone

    EPIDEMIOLOGY   20 ( 3 )   464 - 465   2009年5月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1097/EDE.0b013e31819ed4ed

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  • Influence of fat and carbohydrate proportions on the metabolic profile in patients with type 2 diabetes: a meta-analysis. 査読 国際誌

    Satoru Kodama, Kazumi Saito, Shiro Tanaka, Miho Maki, Yoko Yachi, Mutsumi Sato, Ayumi Sugawara, Kumiko Totsuka, Hitoshi Shimano, Yasuo Ohashi, Nobuhiro Yamada, Hirohito Sone

    Diabetes care   32 ( 5 )   959 - 65   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER DIABETES ASSOC  

    OBJECTIVE: The effects of dietary macronutrient composition on metabolic profiles in patients with type 2 diabetes have been inconsistent. This meta-analysis aimed to elucidate the effect of replacing dietary fat with carbohydrate on glucose and lipid parameters in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: We searched for randomized trials that investigated the effects of two kinds of prescribed diets (a low-fat, high-carbohydrate [LFHC] diet and a high-fat, low-carbohydrate [HFLC] diet); in these studies, energy and protein intake did not differ significantly between the two dietary groups. Nineteen studies that included 306 patients met our inclusion criteria. Median diet composition of carbohydrate/fat in the LFHC and HFLC diets was 58%/24% and 40%/40%, respectively. RESULTS: Changes in values for A1C, fasting plasma glucose (FPG), and total and LDL cholesterol did not differ significantly between the LFHC and HFLC groups. However, the LFHC diet significantly increased fasting insulin and triglycerides by 8% (P = 0.02) and 13% (P < 0.001), respectively, and lowered HDL cholesterol by 6% (P < 0.001) compared with the HFLC diet. There were positive associations among the magnitude of changes in FPG, fasting insulin, and triglycerides for the diets analyzed. However, stratified analysis indicated that the increase in triglycerides was insignificant when accompanied by energy intake restriction. CONCLUSIONS: Our findings suggested that replacing fat with carbohydrate could deteriorate insulin resistance while the adverse effect on triglycerides from the LFHC diet could be avoided by restricting energy intake to a degree sufficient for the attainment of weight reduction.

    DOI: 10.2337/dc08-1716

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  • Effect of low-intensity exercise training on glucose and lipid metabolism and cardiorespiratory fitness in the elderly 査読

    Kodama Satoru, Miao Shu, Kazumi Saito, Haruka Murakami, Tomohiro Okura, Kiyoji Tanaka, Shinya Kuno, Ryuichi Ajisaka, Nobuhiro Yamada, Hirohito Sone

    JOURNAL OF AGING AND PHYSICAL ACTIVITY   16   S111 - S112   2008年7月

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    記述言語:英語   出版者・発行元:HUMAN KINETICS PUBL INC  

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  • Effect of different dietary carbohydrate/fat ratios on glucose metabolism in type 2 diabetic patients: A meta-analysis 査読

    Satoru Kodama, Kazumi Saito, Yoko Yachi, Yoko Ibe, Mihoko Asumi, Miho Maki, Emiko Suzuki, Hitoshi Shimano, Nobuhiro Yamada, Hirohito Sone

    DIABETES   57   A470 - A470   2008年6月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

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  • Factors affecting remission of microalbuminuria in patients with type 2 diabetes: the Tsukuba Kawai Diabetes Registry (TKDR)2 査読

    Kazumi Saito, Koichi Kawaii, Satoru Kodama, Shiro Tanaka, Keni Ro Sakamaki, Ayumi Sugawara, Mut-Sumi Sato, Yasuko Sone, Hitoshi Shimano, Yasuo Ohashi, Nobuhiro Yama, Hirohito Sone

    DIABETES   57   A211 - A211   2008年6月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

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  • [Intervention study for elevating high density lipoprotein cholesterol level]. 査読

    Kodama S, Sone H

    Nihon rinsho. Japanese journal of clinical medicine   65 Suppl 7   264 - 269   2007年7月

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  • Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. 査読 国際誌

    Satoru Kodama, Shiro Tanaka, Kazumi Saito, Miao Shu, Yasuko Sone, Fumiko Onitake, Emiko Suzuki, Hitoshi Shimano, Shigeru Yamamoto, Kazuo Kondo, Yasuo Ohashi, Nobuhiro Yamada, Hirohito Sone

    Archives of internal medicine   167 ( 10 )   999 - 1008   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER MEDICAL ASSOC  

    BACKGROUND: Aerobic exercise is believed to reduce the risk of cardiovascular disease partially through increasing serum levels of high-density lipoprotein cholesterol (HDL-C). However, this effect varies considerably among exercise intervention studies. METHODS: Electronic database searches of MEDLINE (1966-2005) for randomized controlled trials that examined the effect of exercise training on HDL-C level. RESULTS: Twenty-five articles were included. Mean net change in HDL-C level was statistically significant but modest (2.53 mg/dL [0.065 mmol/L]; P<.001). Minimal weekly exercise volume for increasing HDL-C level was estimated to be 900 kcal of energy expenditure per week or 120 minutes of exercise per week. Univariate regression analysis indicated that every 10-minute prolongation of exercise per session was associated with an approximately 1.4-mg/dL (0.036-mmol/L) increase in HDL-C level. In contrast, there was no significant association between exercise frequency or intensity. Multiple meta-regression analyses demonstrated that subjects with a body mass index (calculated as weight in kilograms divided by height in meters squared) less than 28 and total cholesterol level of 220 mg/dL [5.7 mmol/L] or more experienced an approximately 2.1-mg/dL (0.054-mmol/L) larger increase in HDL-C level than those with a body mass index of 28 or more and total cholesterol level less than 220 mg/dL (5.7 mmol/L). CONCLUSIONS: Regular aerobic exercise modestly increases HDL-C level. There appears to exist a minimum exercise volume for a significant increase in HDL-C level. Exercise duration per session was the most important element of an exercise prescription. Exercise was more effective in subjects with initially high total cholesterol levels or low body mass index.

    DOI: 10.1001/archinte.167.10.999

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  • Risk imparted by various parameters of smoking in Japanese men with type 2 diabetes on their development of microalbuminuria - Analysis from the Tsukuba Kawai Diabetes Registry 査読

    Kazumi Saito, Hirohito Sone, Koichi Kawai, Shiro Tanaka, Satoru Kodama, Miao Shu, Emiko Suzuki, Kazuo Kondo, Shigeru Yamamoto, Hitoshi Shimano, Yasuo Ohashi, Nobuhiro Yamada

    DIABETES CARE   30 ( 5 )   1286 - 1288   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/dc06-2149

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  • Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly 査読

    Satoru Kodama, Miao Shu, Kazumi Saito, Haruka Murakami, Kiyoji Tanaka, Shinya Kuno, Ryuichi Ajisaka, Yasuko Sone, Fumiko Onitake, Akimitsu Takahashi, Hitoshi Shimano, Kazuo Kondo, Nobuhiro Yamada, Hirohito Sone

    INTERNAL MEDICINE   46 ( 14 )   1071 - 1077   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Objective Moderate to high intensity exercise training is known to ameliorate the coronary risk factors in relation to an improvement in body composition. However, the benefit of low-intensity and low-volume training for these risk factors remains unclear in elderly people. Therefore, we investigated the effects of low-intensity and low-volume exercise training on blood lipid values and insulin resistance in the elderly.
    Methods A total of 56 healthy elderly individuals (42 females and 14 males) aged 64 +/- 6 years participated in a 12-week exercise program, comprising aerobic training and resistance training.
    Results After the program, there were no significant changes in high-density lipoprotein cholesterol, triglyceride serum levels, or in peak oxygen uptake on average. However, the homeostasis of minimal assessment of insulin resistance (HOMA-IR) value was significantly reduced by 21%. The participants were categorized into tertiles based on initial Body Mass Index (BMI). The Middle-BMI group (non-obese subjects) showed reduced HOMA-IR (2.0 -&gt; 1.3, P&lt;0.01), but this reduction was not associated with the reduction in BMI (r=0.08, P=0.74), whereas the two reductions were significantly associated in the High-BMI group (r=0.61, P=0.01).
    Conclusion Even low-intensity and low-volume exercise training, which would ordinarily be insufficient for improving mean lipid values or aerobic fitness, was found to be effective in improving insulin resistance in the elderly. The improvement in insulin resistance was independent of the improvement in obesity.

    DOI: 10.2169/internalmedicine.46.0096

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  • Distribution of retinylester-storing stellate cells in the arrowtooth halibut, Atheresthes evermanni.

    Yoshikawa K, Imai K, Seki T, Higashi-Kuwata N, Kojima N, Yuuda M, Koyasu K, Sone H, Sato M, Senoo H, Irie T

    2006年10月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cbpa.2006.06.043

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  • Exercise Training for Ameliorating Cardiovascular Risk Factors-focusing on Exercise Intensity and Amount

    Kodama Satoru, Miao Shu, Yamada Nobuhiro, Sone Hirohito

    International Journal of Sport and Health Science   4   325 - 338   2006年

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    記述言語:英語   出版者・発行元:Japan Society of Physical Education, Health and Sport Sciences  

    Exercise training suppresses cardiovascular risk factors by improving lipid/glucose metabolism, insulin resistance and hypertension. There is an optimum amount and intensity of exercise that will suppress each risk factor, although limited information is currently available on this area. For instance, the level of high-density lipoprotein cholesterol seems to be dependent more on the amount than on the intensity of exercise training; the situation with exercise-induced suppression of triglyceride levels is less clear. It is notable that the ability of mild intensity or a low amount of exercise to suppress or prevent cardiovascular risk factors is largely unknown. This knowledge is essential for prescribing safe and effective exercise training to elderly people. At the same time, very few studies on the associations between cardiovascular risk factors in response to exercise can be found. For example, improvement in lipid metabolism or insulin resistance seems to be related to the weight loss seen during exercise training but weight-independent effects could also be observed. The optimal intensity and amount of exercise training for each cardiovascular risk factor and the relationships between the effects of exercise training on each risk factor need to be clarified in the near future in order to establish guidelines that can be applied to the majority of elderly people at risk of cardiovascular diseases.

    DOI: 10.5432/ijshs.4.325

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    その他リンク: http://search.jamas.or.jp/link/ui/2007328852

  • 日本人糖尿病患者における動脈硬化性疾患の現状 : JDCS より

    曽根 博仁, 赤沼 安夫, 山田 信博, JDCSグループ

    糖尿病   46 ( 12 )   903 - 906   2003年12月

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    記述言語:日本語   出版者・発行元:THE JAPAN DIABETES SOCIETY  

    DOI: 10.11213/tonyobyo1958.46.903

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    その他リンク: https://jlc.jst.go.jp/DN/JALC/00234747009?from=CiNii

  • 大規模災害時における糖尿病患者のケア-の重要性 -阪神大震災医療救護班における経験-

    曽根 博仁

    糖尿病   38 ( 3 )   238 - 239   1995年3月

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    記述言語:日本語   出版者・発行元:THE JAPAN DIABETES SOCIETY  

    DOI: 10.11213/tonyobyo1958.38.238

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▶ 全件表示

書籍等出版物

  • スポーツ医学【内科】

    赤間 高雄, 浅川 伸, 伊東 和雄, 内田 直, 坂本 静男, 児玉 暁, 清水 和弘, 曽根 博仁, 夏井 裕明, 難波 聡, 渡部 厚一

    化学同人  2014年  ( ISBN:9784759817058

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    記述言語:日本語

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  • クロール : 児玉暁歌集

    児玉 暁

    砂子屋書房  1989年 

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    記述言語:日本語

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MISC

  • 写真撮影とAIを活用した食事記録スマートフォンアプリによる日常の食事記録の妥当性検証

    北澤勝, 堀川千嘉, 堀川千嘉, 長谷川美代, 武田安永, 治田麻理子, 松林泰弘, 山田貴穂, 児玉暁, 藤原和哉, 曽根博仁

    糖尿病(Web)   66 ( Suppl )   2023年

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  • 耐糖能や年齢で層別化した血清アミラーゼ低値およびその経時的減少が2型糖尿病発症に及ぼす影響の縦断的検討

    池田和泉, 藤原和哉, 大澤妙子, 武田安永, 治田麻里子, 松林泰弘, 児玉暁, 森保道, 本田律子, 門脇孝, 荒瀬康司, 曽根博仁

    糖尿病(Web)   66 ( Suppl )   2023年

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  • 【食事療法と運動療法】運動療法の基礎と臨床 糖尿病・脂質異常症予防・改善のための身体活動のエビデンス

    児玉 暁, 曽根 博仁

    The Lipid   32 ( 1 )   61 - 69   2021年4月

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    担当区分:筆頭著者   記述言語:日本語  

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  • 糖尿病,非糖尿患者における血糖・血圧・脂質・喫煙の管理目標の達成状況と冠動脈疾患発症の検討

    藤原和哉, 山田万祐子, 石澤正博, 山本正彦, 清田浩康, 山中菜詩, 児玉暁, 曽根博仁

    日本疫学会学術総会講演集(Web)   30th   2020年

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  • Impact of Prior Coronary Artery Disease (CAD)/Cerebrovascular Disease (CVD) and Diabetes Mellitus (DM) on Incident CAD/CVD in Japanese

    Kazuya Fujihara, Yasuhiro Matsubayashi, Mayuko Harada, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Masanori Kaneko, Hiroyasu Seida, Nauta Yamanaka, Satoru Kodama, Hirohito Sone

    DIABETES   68   2019年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db19-450-P

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  • 血清アミラーゼ値およびその経時変化が2型糖尿病発症に及ぼす影響の定量的検討

    石井 大, 藤原 和哉, 根立 梨奈, 原田 万佑子, 松林 泰弘, 斎藤 和美, 児玉 暁, 森 保道, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 219   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • メタ解析からみた糖尿病の心不全発症危険因子としての疫学的エビデンス

    児玉暁, 藤原和哉, 石澤正博, 石黒創, 松林泰弘, 岩永みどり, 山田貴穂, 渡辺賢一, 加藤公則, 曽根博仁

    日本内科学会雑誌   108   270   2019年2月

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    記述言語:日本語  

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  • 耐糖能別にみた肥満及び代謝異常が冠動脈疾患発症へ及ぼす影響の縦断的検討

    藤原和哉, 松林泰弘, 児玉暁, 曽根博仁

    日本内科学会雑誌   108   187   2019年2月

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  • 血清アミラーゼ値およびその経時変化が2型糖尿病発症に及ぼす影響の定量的検討

    石井大, 藤原和哉, 根立梨奈, 原田万佑子, 松林泰弘, 斎藤和美, 児玉暁, 森保道, 本田律子, 荒瀬康司, 曽根博仁

    糖尿病(Web)   62 ( Suppl )   2019年

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  • 糖尿病患者における心不全発症リスクの系統レビュー・メタ解析

    児玉暁, 藤原和哉, 岩永みどり, 鈴木浩史, 山田貴穂, 渡辺賢一, 加藤公則, 曽根博仁

    糖尿病合併症   32 ( Supplement 1 )   287   2018年10月

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  • 糖尿病患者の下肢切断の頻度とリスク因子の検討

    金子正儀, 藤原和哉, 原田万祐子, 松林泰弘, 北澤勝, 石井大, 清田浩康, 山中菜詩, 児玉暁, 曽根博仁

    糖尿病合併症   32 ( Supplement 1 )   291   2018年10月

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    記述言語:日本語  

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  • 心血管 耐糖能別にみた肥満及び代謝異常が冠動脈疾患発症へ及ぼす影響の検討

    藤原 和哉, 松林 泰弘, 原田 万祐子, 山本 正彦, 大澤 妙子, 金子 正儀, 松永 佐澄志, 山田 貴穂, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁

    糖尿病合併症   32 ( Suppl.1 )   206 - 206   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • メタ解析を用いた、2型糖尿病患者におけるレジスタンストレーニングの有用性の検討

    石黒 創, 児玉 暁, 森川 咲子, 堀川 千嘉, 石井 大, 治田 麻理子, 張 かおり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本臨床運動療法学会学術集会プログラム・抄録集   37回 ( 1 )   53 - 53   2018年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本臨床運動療法学会  

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  • 尿酸高値は非アルコール性脂肪性肝疾患発症の独立したリスク因子である

    原茂子, 原茂子, 戸田晶子, 大本由樹, 辻裕之, 斎藤和美, 斎藤和美, 児玉暁, 児玉暁, 曽根博仁, 荒瀬康司

    人間ドック   33 ( 2 )   321 - 321   2018年8月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • Effect of Number of Achieved Targets for Risk Factors on Coronary Artery Disease (CAD) in Those With and Without Diabetes Mellitus (DM)

    Kazuya Fujihara, Yasuhiro Matsubayashi, Masaru Kitazawa, Masahiko Yamamoto, Taeko Osawa, Masanori Kaneko, Nauta Yamanaka, Hiroyasu Seida, Kiminori Kato, Satoru Kodama, Hirohito Sone

    DIABETES   67   2018年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-442-P

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  • Effects of Treatment-Achieved HbA1c on Incidence of Micro-/Macrovascular Complications in Patients with Diabetes Mellitus

    Mayuko Harada, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Yasuhiro Matsubayashi, Satoshi Matsunaga, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

    DIABETES   67   2018年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-444-P

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  • Education for Family Members Is Effective for Improved Glycemic Control of Patients with Type 2 Rather than Type 1 Diabetes Mellitus-A Meta-analysis

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Yoko Yachi, Masahiro Ishizawa, Satoshi Matsunaga, Shiro Tanaka, Kiminori Kato, Hirohito Sone

    DIABETES   67   2018年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-823-P

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  • 耐糖能及び肥満の有無別にみた代謝異常が冠動脈疾患発症に及ぼす影響の検討

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    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   50th   336 (WEB ONLY) - 336   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 症例検討 脂質代謝異常症への多角的アプローチ 124 不安定な体重は2型糖尿病発症リスクを高めるか?

    児玉暁, 児玉暁

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    記述言語:日本語  

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  • 脂質代謝異常症への多角的アプローチ 不安定な体重は2型糖尿病発症リスクを高めるか?

    児玉 暁

    The Lipid   29 ( 2 )   222 - 225   2018年4月

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    記述言語:日本語   出版者・発行元:(株)メディカルレビュー社  

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  • 耐糖能及び肥満の有無に関わらず代謝異常は冠動脈疾患発症リスクを増大させる

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    糖尿病   61 ( Suppl.1 )   S - 260   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 年齢層別に見た血清アミラーゼ値と2型糖尿病発症との関連

    石井 大, 藤原 和哉, 治田 麻理子, 原田 万佑子, 松林 泰弘, 斎藤 和美, 児玉 暁, 森 保道, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 161   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 勤労世代男性における各耐糖能が冠動脈疾患発症に及ぼす影響の検討

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    日本疫学会学術総会講演集(Web)   28th   76 (WEB ONLY)   2018年2月

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  • 信頼性の高い医療情報の見分け方

    児玉暁

    新潟県医師会報   ( 814 )   2‐6 - 6   2018年1月

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    記述言語:日本語   出版者・発行元:新潟県医師会  

    情報化社会の普及に伴い、医療情報が氾濫し信頼性の低い情報の増加に繋がっている。現在では臨床医が最新の診療を実践するためには、治療手技などの医療情報は、system(教科書型の情報源)ではなく、個別の医学研究であるstudyから入手しなければならない場合が多い。信頼できる研究の着眼点を以下の項目に分けて概説した。1)医学研究の分類、2)観察研究の分類、3)医学研究の信頼性、4)介入研究の簡便評価法、5)観察研究の簡便評価法、6)診断研究の簡便評価法、について述べた。

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  • 耐糖能及び肥満の有無に関わらず代謝異常は冠動脈疾患発症リスクを増大させる

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    糖尿病(Web)   61 ( Suppl )   2018年

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    糖尿病(Web)   61 ( Suppl )   2018年

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    記述言語:日本語   出版者・発行元:杏林書院  

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  • 心血管疾患 糖尿病が冠動脈疾患発症へ与える影響は若年者と中年では大きく異なる

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    糖尿病合併症   31 ( Suppl.1 )   202 - 202   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 心血管疾患 糖尿病が冠動脈疾患発症へ与える影響は若年者と中年では大きく異なる

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    糖尿病合併症   31 ( Suppl.1 )   202 - 202   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 【生産年齢期の身体活動による生活習慣病予防】 糖尿病予防に対する身体活動エビデンス

    児玉 暁, 曽根 博仁

    体育の科学   67 ( 10 )   675 - 681   2017年10月

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    記述言語:日本語   出版者・発行元:(株)杏林書院  

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    人間ドック   32 ( 2 )   307 - 307   2017年8月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • 骨粗鬆症検診と体力測定の関係についての縦断的解析

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    人間ドック   32 ( 2 )   308 - 308   2017年8月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • Pulse Pressure and HbA1c Levels Are Significant Predictors of Vision-Threatening Eye Diseases in Japanese Patients with Diabetes Mellitus

    Masahiko Yamamoto, Kazuya Fujihara, Risa Igarashi, Sakiko Yoshizawa, Yasuhiro Matsubayashi, Takaho Yamada, Satoshi Mat-Sunaga, Chie Ito, Nauta Yamanaka, Hiruma Hasebe, Takeo Fukuchi, Shiro Tanaka, Kiminori Katou, Satoru Kodama, Hirohito Sone

    DIABETES   66   A431 - A431   2017年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Impact of Individual Components and Their Combinations within a Family History (FH) of Diabetes on the Development of Diabetes

    Risa Igarashi, Dai Ishii, Yasunaga Takeda, Kazuya Fujihara, Mariko Hatta, Yoshie Oshikane, Yasuhiro Matsubayashi, Kazumi Saito, Satoru Kodama, Ritsuko Honda, Yasuji Arase, Hirohito Sone

    DIABETES   66   A418 - A418   2017年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • 糖尿病に起因する重症視力障害発症のリスク因子およびHbA1cの閾値に関する検討

    山本正彦, 藤原和哉, 伊藤知恵, 錦野理絵, 山中菜詩, 児玉暁, 長谷部日, 田中司朗, 曽根博仁

    糖尿病(Web)   60 ( Suppl )   S.140(J‐STAGE) - 140   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病患者における透析導入のリスク因子の検討

    大澤妙子, 山本正彦, 石澤正博, 松林泰弘, 松永佐澄志, 藤原和哉, 山田貴穂, 小石美恵子, 伊藤知恵, 山中菜詩, 児玉暁, 加藤公則, 曽根博仁

    糖尿病(Web)   60 ( Suppl )   S.245(J‐STAGE) - 245   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 骨粗鬆症検診と体力測定の関係―人間ドック受診者では糖代謝異常と骨密度と関連しない―

    加藤公則, 加藤公則, 石澤正博, 岩永みどり, 児玉暁, 藤原和哉, 小林隆司, 田代稔, 田代稔, 小林篤子, 上村伯人, 佐藤幸示, 曽根博仁

    糖尿病(Web)   60 ( Suppl )   S.216(J‐STAGE) - 216   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病の詳細な家族歴が2型糖尿病発症リスクに与える影響の定量的検討

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  • 糖尿病に起因する重症視力障害発症のリスク因子およびHbA1cの閾値に関する検討

    山本 正彦, 藤原 和哉, 伊藤 知恵, 錦野 理絵, 山中 菜詩, 児玉 暁, 長谷部 日, 田中 司朗, 曽根 博仁

    糖尿病   60 ( Suppl.1 )   S - 140   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 骨粗鬆症検診と体力測定の関係 人間ドック受診者では糖代謝異常と骨密度と関連しない

    加藤 公則, 石澤 正博, 岩永 みどり, 児玉 暁, 藤原 和哉, 小林 隆司, 田代 稔, 小林 篤子, 上村 伯人, 佐藤 幸示, 曽根 博仁

    糖尿病   60 ( Suppl.1 )   S - 216   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病患者における透析導入のリスク因子の検討

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    糖尿病   60 ( Suppl.1 )   S - 245   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病の詳細な家族歴が2型糖尿病発症リスクに与える影響の定量的検討

    五十嵐 理沙, 藤原 和哉, 治田 麻理子, 押鐘 芳恵, 松林 泰弘, 斎藤 和美, 児玉 暁, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   60 ( Suppl.1 )   S - 281   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 耐糖能別にみた収縮期血圧が透析導入に及ぼす影響の検討

    古谷 篤, 藤原 和哉, 五十嵐 理沙, 山本 正彦, 石澤 正博, 松林 泰弘, 松永 佐澄志, 加藤 公則, 伊藤 知恵, 小石 美恵子, 山中 菜詩, 児玉 暁, 曽根 博仁

    糖尿病   60 ( Suppl.1 )   S - 287   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 健常女性における思春期のやせの要因解明および予防プログラムの構築の検討

    谷内洋子, 広瀬歩美, 平澤玲子, 児玉暁, 曽根博仁

    千葉県立保健医療大学紀要   8 ( 1 )   101 - 101   2017年3月

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    記述言語:日本語   出版者・発行元:千葉県立保健医療大学  

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  • 糖尿病患者の家族に対する教育が患者血糖に及ぼす効果のメタ分析

    児玉 暁, 藤原 和哉, 山本 正彦, 石澤 正博, 石黒 創, 松林 泰弘, 松永 佐澄志, 山田 貴穂, 加藤 公則, 曽根 博仁

    日本内科学会雑誌   106 ( Suppl. )   211 - 211   2017年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • 糖尿病患者の家族に対する教育が患者血糖に及ぼす効果のメタ分析

    児玉 暁, 藤原 和哉, 山本 正彦, 石澤 正博, 石黒 創, 松林 泰弘, 松永 佐澄志, 山田 貴穂, 加藤 公則, 曽根 博仁

    日本内科学会雑誌   106 ( Suppl. )   211 - 211   2017年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • 日本人男女における2型糖尿病発症予測のためのBMIおよびウエスト周囲径(WC)閾値の検討:NIWELLS

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    日本疫学会学術総会講演集(Web)   27th   74 (WEB ONLY)   2017年1月

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  • 働き盛り世代男性における耐糖能の冠動脈疾患発症への影響の検討

    藤原 和哉, 五十嵐 理沙, 山本 正彦, 石澤 正博, 松林 泰弘, 松永 佐澄志, 加藤 公則, 伊藤 知恵, 小石 美恵子, 山中 菜詩, 児玉 暁, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   43   79 - 79   2017年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 耐糖能別にみた収縮期血圧が透析導入に及ぼす影響の検討

    古谷篤, 藤原和哉, 五十嵐理沙, 山本正彦, 石澤正博, 松林泰弘, 松永佐澄志, 加藤公則, 伊藤知恵, 小石美恵子, 山中菜詩, 児玉暁, 曽根博仁

    糖尿病(Web)   60 ( Suppl )   S.287(J‐STAGE)   2017年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • Characteristics of patients with type 2 diabetes who achieved better glycaemic control through resistance training: a meta-analysis

    H. Ishiguro, S. Kodama, S. Matsunaga, C. Horikawa, Y. Heianza, N. Ohara, T. Yamada, A. Suzuki, O. Hanyu, H. Sone

    DIABETOLOGIA   57   S259 - S259   2014年9月

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  • 脂肪肝の臨床背景におよぼすアルコールのインパクト

    荒瀬康司, 陣内由紀, 児玉暁, 岩男暁子, 四倉淑江, 田邉真帆, 尾形知英, 辻裕之, 原茂子, 曽根博仁

    人間ドック   29 ( 2 )   312 - 312   2014年7月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • 新医学へと展開する疫学・統計学 抗加齢医学における実例と今後 運動による健康長寿の可能性 臨床疫学の視点から

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    日本抗加齢医学会総会プログラム・抄録集   14回   285 - 285   2014年6月

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    記述言語:日本語   出版者・発行元:(一社)日本抗加齢医学会  

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  • Predictive Value of Combined Single Nucleotide Polymorphisms for Diabetes Mellitus-A Meta-analysis

    Satoru Kodama, Chika Horikawa, Satoshi Matsunaga, Kazuya Fujihara, Yoriko Heianza, Ayumi Hirose, Takaho Yamada, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

    DIABETES   63   A360 - A360   2014年6月

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  • Diabetes Risk Related to Carrying 1 Risk Allele of a Diabetes-Susceptible Gene Is Comparable to That Related to 1 Unit of Increased Body Mass Index: A Meta-analysis

    Chika Horikawa, Satoru Kodama, Satoshi Matsunaga, Sakiko Yoshizawa, Yoriko Heianza, Yoko Yachi, Nobumasa Ohara, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

    DIABETES   63   A360 - A360   2014年6月

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  • Resistance Exercise Was Effective in Improving Glycemic Control but Inferior to Aerobic Exercise for Patients with Type 2 Diabetes Mellitus-A Meta-analysis

    Hajime Ishiguro, Satoru Kodama, Chika Horikawa, Hiroshi Suzuki, Satoshi Matsunaga, Yoriko Heianza, Takaho Yamada, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

    DIABETES   63   A185 - A185   2014年6月

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  • Magnitude of Risk of Diabetes Mellitus in Relation to Carrying Risk Alleles of Diabetes-Susceptible Genes Was Not Influenced by Covariates: A Meta-analysis

    Hajime Ishiguro, Satoru Kodama, Chika Horikawa, Kazuo Furukawa, Hiromi Suzuki, Kazuya Fujiwara, Yoriko Heianza, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

    DIABETES   63   A360 - A360   2014年6月

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  • Stability and Changes in the Metabolically Healthy Overweight or Obese State and the Risk of Development of Future Type 2 Diabetes

    Yoriko Heianza, Akiko Suzuki, Kiminori Kato, Kazuya Fujihara, Takaho Yamada, Osamu Hanyu, Satoru Kodama, Koji Sato, Hirohito Sone

    DIABETES   63   A21 - A21   2014年6月

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  • Risk of Development of Type 2 Diabetes by Overall Obesity, Abdominal Obesity, and Metabolic Abnormalities-Does Metabolically Healthy Obesity Really Exist?

    Yoriko Heianza, Kiminori Kato, Akiko Suzuki, Chika Horikawa, Satoshi Matsunaga, Sakiko Yoshizawa, Osamu Hanyu, Satoru Kodama, Koji Sato, Hirohito Sone

    DIABETES   63   A519 - A519   2014年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • 糖尿病患者は非糖尿病患者よりもヘリコバクター・ピロリ菌除菌成功率が低い メタ解析

    堀川 千嘉, 児玉 暁, 藤原 和哉, 谷内 洋子, 羽入 修, 曽根 博仁, 島野 仁

    成人病と生活習慣病   44 ( 5 )   603 - 603   2014年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 糖尿病患者におけるヘリコバクター・ピロリ菌感染と血糖コントロールの関係 メタ解析

    堀川 千嘉, 児玉 暁, 藤原 和哉, 谷内 洋子, 羽入 修, 曽根 博仁, 島野 仁

    成人病と生活習慣病   44 ( 5 )   583 - 583   2014年5月

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  • 糖尿病スクリーニング後の早期治療と未治療放置が短期間の血糖コントロールに与える影響の大規模疫学的検討

    五十嵐理沙, 平安座衣子, 児玉暁, 由澤咲子, 山田貴穂, 藤原和哉, 鈴木亜希子, 羽入修, 曽根博仁

    糖尿病   57 ( Supplement 1 )   S.144 - 144   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 肥満と臨床代謝指標の変化がその後の糖尿病発症に与える影響についての大規模縦断的検討:the Niigata Welness Study

    羽入修, 平安座依子, 加藤公則, 松永佐澄志, 田代稔, 児玉暁, 藤原和哉, 鈴木亜希子, 佐藤幸示, 曽根博仁

    糖尿病   57 ( Supplement 1 )   S.176   2014年4月

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  • 健康的肥満(Metabolically Healthy Obesity)と2型糖尿病発症に関する大規模前向き研究:TOPICS

    平安座依子, 児玉暁, 原茂子, 謝勲東, 森保道, 辻裕之, 齋藤和美, 藤原和哉, 島野仁, 羽入修, 鈴木亜希子, 荒瀬康司, 曽根博仁

    糖尿病   57 ( Supplement 1 )   S.286 - 286   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 妊娠中期の身体活動量が糖代謝に及ぼす影響の検討(TWC Study)

    谷内洋子, 田中康弘, 西端泉, 由澤咲子, 藤原和哉, 児玉暁, 鈴木亜希子, 羽入修, 曽根博仁

    糖尿病   57 ( Supplement 1 )   S.377 - 377   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病患者における、ヘリコバクター・ピロリ菌感染とその除菌成功率 メタアナリシスによる報告

    堀川 千嘉, 児玉 暁, 藤原 和哉, 谷内 洋子, 羽入 修, 島野 仁, 曽根 博仁

    糖尿病   57 ( Suppl.1 )   S - 451   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 問診による2型糖尿病予測能のメタ分析

    由澤 咲子, 児玉 暁, 藤原 和哉, 堀川 千嘉, 菅原 歩美, 谷内 洋子, 山田 貴穂, 鈴木 亜希子, 羽入 修, 曽根 博仁

    糖尿病   57 ( Suppl.1 )   S - 205   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 肥満と臨床代謝指標の変化がその後の糖尿病発症に与える影響についての大規模縦断的検討 the Niigata Wellness Study

    羽入 修, 平安座 依子, 加藤 公則, 松永 佐澄志, 田代 稔, 児玉 暁, 藤原 和哉, 鈴木 亜希子, 佐藤 幸示, 曽根 博仁

    糖尿病   57 ( Suppl.1 )   S - 176   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 【糖尿病の臨床研究をどう紐解くか-批判的吟味を実臨床へつなぐ-】 システマティックレビュー・メタアナリシスを紐解く(2)"The association between dietary patterns and type 2 diabetes:a systematic review and meta-analysis of cohort studies"を題材に

    児玉 暁, 曽根 博仁

    プラクティス   31 ( 2 )   205 - 209   2014年3月

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

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  • メタ分析によるゲノムワイド関連解析(GWAS)における糖尿病関連複数遺伝子と糖尿病との定量的相関性の検討

    児玉暁, 藤原和哉, 松永佐澄志, 古川和郎, 山田貴穂, 鈴木亜希子, 島野仁, 羽入修, 曽根博仁

    日本内科学会雑誌   103 ( Suppl. )   152 - 152   2014年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

    J-GLOBAL

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  • 糖尿病患者のヘリコバクター・ピロリ菌感染における血糖コントロール及び除菌成功率との関連性:メタ解析

    堀川千嘉, 児玉暁, 藤原和哉, 谷内洋子, 羽入修, 島野仁, 曽根博仁

    J Epidemiol   24 ( Supplement 1 )   102   2014年1月

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  • ヘモグロビンA1c検査による糖尿病スクリーニングとその後の通院治療開始が血糖コントロールに与える影響

    平安座依子, 羽入修, 鈴木亜希子, 児玉暁, 島野仁, 曽根博仁

    J Epidemiol   24 ( Supplement 1 )   72   2014年1月

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  • 現在BMIと20歳時や生涯最大BMIを組み合わせた高血圧発症予測の縦断的検討

    平安座依子, 児玉暁, 齋藤和美, 島野仁, 田中司朗, 荒瀬康司, 原茂子, 曽根博仁

    J Epidemiol   24 ( Supplement 1 )   72   2014年1月

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  • 妊娠中の母体の血糖状態と低出生体重児出産との関連(TWC Study)

    谷内洋子, 田中康弘, 西端泉, 由澤咲子, 藤原和哉, 児玉暁, 鈴木亜希子, 羽入修, 曽根博仁

    J Epidemiol   24 ( Supplement 1 )   114   2014年1月

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  • 糖尿病患者は非糖尿病患者よりもヘリコバクター・ピロリ菌除菌成功率が低い メタ解析

    堀川 千嘉, 児玉 暁, 藤原 和哉, 谷内 洋子, 羽入 修, 島野 仁, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   40   75 - 75   2014年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 糖尿病患者におけるヘリコバクター・ピロリ菌感染と血糖コントロールの関係 メタ解析

    堀川 千嘉, 児玉 暁, 藤原 和哉, 谷内 洋子, 羽入 修, 島野 仁, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   40   55 - 55   2014年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 妊娠初期HbA1c値および空腹時血糖値と妊娠糖尿病発症との関連の検討(TWC Study)

    谷内 洋子, 田中 康弘, 西端 泉, 広瀬 歩美, 児玉 暁, 曽根 博仁

    DOHaD研究   3 ( 1 )   44 - 44   2014年

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    記述言語:日本語   出版者・発行元:日本DOHaD研究会  

    第3回日本DOHaD研究会学術集会 抄録集 【ポスター発表】

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  • 日本人の食事摂取基準の策定に資する代謝性疾患の栄養評価に関する研究「糖尿病合併症と食事に関する最近の研究のレビュー」

    曽根博仁, 児玉暁

    日本人の食事摂取基準の策定に資する代謝性疾患の栄養評価に関する研究 平成25年度 総括・分担研究報告書   367 - 410   2014年

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  • 運動による健康長寿の可能性―臨床疫学の視点から

    曽根博仁, 田中司朗, 児玉暁

    日本抗加齢医学会総会プログラム・抄録集   14th   285   2014年

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  • 妊娠初期空腹時血糖およびHbA1c値両者の同時測定は妊娠糖尿病発症を予測する指標として有用である(TWC Study)

    谷内洋子, 田中康弘, 西端泉, 由澤咲子, 藤原和哉, 児玉暁, 鈴木亜希子, 羽入修, 曽根博仁

    糖尿病と妊娠   13 ( 2 )   S.80 - 80   2013年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病・妊娠学会  

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  • Predictive ability of simple clinical information without blood tests for future incident diabetes: a meta-analysis

    S. Yoshizawa, S. Kodama, K. Fujihara, C. Horikawa, A. Sugawara, Y. Heianza, Y. Yachi, S. Tanaka, S. Minakawa, T. Yamada, A. Suzuki, O. Hanyu, H. Sone

    DIABETOLOGIA   56   S137 - S137   2013年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • 非アルコール性脂肪性肝障害で耐糖能異常から耐糖能正常に改善した症例の検討

    荒瀬康司, 有元佐多雄, 守永眞一, 児玉暁, 岩男暁子, 四倉淑枝, 田邉真帆, 辻裕之, 尾形知英, 原茂子

    人間ドック   28 ( 2 )   369 - 369   2013年7月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • Utility of Elevated 1-h Glucose Values for Assessment of Pathogenesis of Type 2 Diabetes in Japanese Individuals

    Yoriko Heianza, Yasuji Arase, Satoru Kodama, Shiun Dong Hsieh, Kazuya Fujihara, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Kazumi Saito, Hitoshi Shimano, Shigeko Hara, Hirohito Sone

    DIABETES   62   A380 - A380   2013年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Effect of Helicobacter Pylori (HP) Infection on Glycemic Control in Patients With Diabetes: A Meta-Analysis

    Sakiko Yoshizawa, Satoru Kodama, Ryoko Tajima, Kazuya Fujihara, Chika Horikawa, Yoko Yachi, Akiko Suzuki, Osamu Hanyu, Hitoshi Shimano, Hirohito Sone

    DIABETES   62   A412 - A412   2013年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Relationship of Living Alone With Undiagnosed Diabetes in Japan: Toranomon Hospital Health Management Center Study

    Yoriko Heianza, Yasuji Arase, Satoru Kodama, Shiun Dong Hsieh, Ayumi Sugawara, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Kazumi Saito, Hitoshi Shimano, Shigeko Hara, Hirohito Sone

    DIABETES   62   A209 - A209   2013年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Comparison of Significance of Body Weight (BW) Change Associated With Subsequent Type 2 Diabetes (T2DM) Risk in Different Periods of Adulthood-A Meta-Analysis

    Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Ryoko Tajima, Sakiko Yoshizawa, Kazumi Saito, Shiro Tanaka, Osamu Hanyu, Hitoshi Shimano, Hirohito Sone

    DIABETES   62   A20 - A21   2013年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Low Eradication Rate of Helicobacter Pylori (HP) in Patients With Diabetes: A Meta-Analysis

    Chika Horikawa, Satoru Kodama, Sakiko Yoshizawa, Kazuya Fujihara, Ryoko Tajima, Yoko Yachi, Akiko Suzuki, Osamu Hanyu, Hitoshi Shimano, Hirohito Sone

    DIABETES   62   A408 - A408   2013年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Relationship between Body Weight (BW) Gain from Early Adulthood and Incident Type 2 Diabetes (T2DM): A Meta-Analysis

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Ryoko Tajima, Yoriko Heianza, Yoko Yachi, Kaoruko T. Iida, Hitoshi Shimano, Osamu Hanyu, Hirohito Sone

    DIABETES   62   A389 - A389   2013年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • HbA1C in the First Trimester Predicts Gestational Diabetes Independent of Fasting Glucose in Japanese Pregnant Women: TWC Study

    Yoko Yachi, Yasuhiro Tanaka, Ayumi Sugawara, Izumi Nishibata, Chika Horikawa, Yoriko Heianza, Kazuya Fujihara, Osamu Hanyu, Satoru Kodama, Hirohito Sone

    DIABETES   62   A358 - A358   2013年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome-A Meta-Analysis

    Kazuya Fujihara, Satoru Kodama, Chika Horikawa, Ayumi Sugawara, Yoriko Heianza, Hitoshi Shimano, Yoko Yachi, Kazumi Saito, Osamu Hanyu, Hirohito Sone

    DIABETES   62   A397 - A397   2013年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • 2型糖尿病患者におけるMDA‐LDLを用いた脂質指標の冠動脈狭窄病変予測能の検討

    藤原和哉, 鈴木浩明, 佐藤明, 石津智子, 平安座依子, 児玉暁, 高橋昭光, 小林和人, 矢藤繁, 矢作直也, 野牛宏晃, 曽根博仁, 島野仁

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   45th   2-P-234 (WEB ONLY) - 312   2013年6月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • メタ解析 成人においてどの時期の体重増加が2型糖尿病発症に大きく関わるか?

    児玉 暁, 堀川 千嘉, 藤原 和哉, 由澤 咲子, 伊部 陽子, 平安座 依子, 谷内 洋子, 鈴木 亜紀子, 羽入 修, 曽根 博仁

    成人病と生活習慣病   43 ( 5 )   629 - 629   2013年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 単身生活や他の生活習慣と2型糖尿病に関する大規模検討:The Toranomon Hospital Health Management Center Study

    平安座依子, 原茂子, 藤原和哉, 謝勲東, 齋藤和美, 辻裕之, 児玉暁, 島野仁, 荒瀬康司, 曽根博仁

    日本栄養・食糧学会大会講演要旨集   67th   169 - 169   2013年4月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • 単身生活と未診断2型糖尿病に関する大規模検討:Toranomon Hospital Health Management Center Study(TOPICS)

    平安座依子, 原茂子, 児玉暁, 謝勲東, 羽入修, 齋藤和美, 山田信博, 島野仁, 荒瀬康司, 曽根博仁

    糖尿病   56 ( Supplement 1 )   S.423 - 423   2013年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 妊娠初期HbA1c値と妊娠糖尿病発症との関連の検討(TWC Study)

    谷内洋子, 田中康弘, 西端泉, 児玉暁, 鈴木亜希子, 羽生修, 曽根博仁

    糖尿病   56 ( Supplement 1 )   S.351 - 351   2013年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 脂質摂取と2型糖尿病リスクとの関連性についてのメタ解析

    田島 諒子, 児玉 暁, 堀川 千嘉, 藤原 和哉, 吉澤 咲子, 平安座 依子, 菅原 歩美, 谷内 洋子, 齋藤 あき, 飯田 薫子, 曽根 博仁

    日本栄養・食糧学会大会講演要旨集   67回   153 - 153   2013年4月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • RE: "COMPARISONS OF THE STRENGTH OF ASSOCIATIONS WITH FUTURE TYPE 2 DIABETES RISK AMONG ANTHROPOMETRIC OBESITY INDICATORS, INCLUDING WAIST-TO-HEIGHT RATIO: A META-ANALYSIS" REPLY

    Satoru Kodama, Hirohito Sone

    AMERICAN JOURNAL OF EPIDEMIOLOGY   177 ( 8 )   863 - 863   2013年4月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    DOI: 10.1093/aje/kwt036

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  • 大学生に対する多角的栄養教育プログラムの構築

    伊部陽子, 平安座依子, 飯島和子, 宮川八平, 布施泰子, 堀口祐子, 水庭真紀子, 三橋典代, 深谷美架, 児玉暁, 曽根博仁

    Campus Health   50 ( 1 )   264 - 266   2013年3月

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    記述言語:日本語   出版者・発行元:(公社)全国大学保健管理協会  

    大学生の栄養教育プログラム作成の検討に資することを目的に、本学(大学)農学部1年生80名(男子35名、女子45名)へ食物摂取状況および食物摂取の知識・態度・行動などについてアンケート調査を行った。その結果、国民健康栄養調査(18〜29歳)との比較では、男女とも食物繊維・鉄分・カルシウムが不足傾向、野菜、魚介類の摂取が不足傾向であった。また、食物摂取に対する知識・態度・行動レベルでは、男子学生より女子学生の方が高値を示す項目が多かった。

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  • 定量的メタ解析:糖尿病患者における脈圧(PP),平均血圧(MAP)と将来の心血管疾患(CVD)発症リスクとの関連性

    児玉暁, 藤原和哉, 齋藤和美, 羽入修, 曽根博仁

    日本内科学会雑誌   102 ( Suppl. )   211 - 211   2013年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • 2型糖尿病発症に至るまでのBMIの長期変化に関する大規模縦断的検討:TOPICS

    平安座依子, 原茂子, 謝勲東, 齋藤和美, 辻裕之, 羽入修, 児玉暁, 島野仁, 山田信博, 荒瀬康司, 曽根博仁

    J Epidemiol   23 ( Supplement 1 )   97   2013年1月

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    記述言語:日本語  

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  • 糖尿病と閉塞性睡眠時無呼吸症候群の関連性及び方向性のメタ解析

    藤原和哉, 児玉暁, 堀川千嘉, 平安座依子, 由澤咲子, 菅原歩美, 平澤玲子, 谷地洋子, 斎藤和美, 島野仁, 山田信博, 曽根博仁

    J Epidemiol   23 ( Supplement 1 )   130   2013年1月

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    記述言語:日本語  

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  • ウエスト周囲長・身長比による2型糖尿病予測スクリーニング精度の検討:TOPICS

    平安座依子, 謝勲東, 児玉暁, 辻裕之, 齋藤和美, 島野仁, 荒瀬康司, 原茂子, 曽根博仁

    J Epidemiol   23 ( Supplement 1 )   96   2013年1月

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    記述言語:日本語  

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  • メタ解析 成人においてどの時期の体重増加が2型糖尿病発症に大きく関わるか?

    児玉 暁, 堀川 千嘉, 藤原 和哉, 由澤 咲子, 平安座 依子, 伊部 陽子, 谷内 洋子, 鈴木 亜希子, 羽入 修, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   39   65 - 65   2013年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 閉塞性睡眠時無呼吸症候群(OSA)は、糖尿病発症関連因子である

    藤原 和哉, 児玉 暁, 堀川 千嘉, 平安座 依子, 由澤 咲子, 菅原 歩, 平澤 玲子, 谷地 洋子, 斎藤 和美, 島野 仁, 山田 信博, 曽根 博仁

    日本内分泌学会雑誌   88 ( 3 )   1073 - 1073   2012年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 妊娠中の母体の血糖状態と低出生体重児出産との関連の検討

    谷内洋子, 田中康弘, 西端泉, 菅原歩美, 児玉暁, 斎藤和美, 曽根博仁

    糖尿病と妊娠   12 ( 2 )   S.80 - 80   2012年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病・妊娠学会  

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  • Comparison of Framingham risk score, UKPDS risk engine, maximum-IMT, and LDL-C/HDL-C ratio for predicting coronary plaque in asymptomatic patients with type 2 diabetes

    K. Fujihara, H. Suzuki, A. Sato, S. Kodama, Y. Heianza, T. Ishizu, K. Saito, H. Iwasaki, K. Kobayashi, S. Yatoh, A. Takahashi, N. Yamada, H. Sone, H. Shimano

    DIABETOLOGIA   55   S494 - S494   2012年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • High normal HbA1c levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8)

    Y. Heianza, Y. Arase, K. Fujihara, H. Tsuji, K. Saito, S. D. Hsieh, S. Kodama, H. Shimano, N. Yamada, S. Hara, H. Sone

    DIABETIC MEDICINE   29 ( 10 )   1285 - 1290   2012年10月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    Diabet. Med. 29, 12851290 (2012) Abstract Aims We aimed to characterize the association of insulin resistance, impaired insulin secretion and beta-cell dysfunction in relation to HbA1c levels in a non-diabetic range in Japanese individuals without clinically diagnosed diabetes. Methods This cross-sectional study included 1444 individuals without a history of outpatient treatment of diabetes or use of insulin or oral hypoglycaemic agents. The homeostasis model assessment of insulin resistance and beta-cell function, insulinogenic index, Matsuda index and disposition index were calculated using data from 75-g oral glucose tolerance tests and compared across quintile (Q) categories of HbA1c levels. Results Fasting plasma glucose and 30-min and 60-min plasma glucose (PG) levels were significantly higher when HbA1c exceeded 36 mmol/mol (5.4%). A HbA1c concentration of 3637 mmol/mol (5.45.5%) (Q3) was significantly associated with a 15% lower homeostasis model assessment of beta-cell function value and 31% lower insulinogenic index value compared with HbA1c = 32 mmol/mol (= 5.1%) (Q1) (P &lt;0.01). Further, a HbA1c concentration of 3840 mmol/mol (5.65.8%) (Q4) was associated with 17% (P &lt;0.01) and 24% (P &lt;0.05) reductions in those indexes, respectively. However, the homeostasis model assessment of insulin resistance was not significantly elevated and the Matsuda index was not significantly lower unless HbA1c exceeded 41 mmol/mol (5.9%). Individuals with HbA1c = 41 mmol/mol (= 5.9%) (Q5) had a 69% lower disposition index than those with a HbA1c concentration of = 32 mmol/mol (= 5.1%) (Q1). Conclusions Elevated HbA1c levels = 41 mmol/mol (= 5.9%) were associated with substantial reductions in insulin secretion, insulin sensitivity and beta-cell dysfunction in Japanese individuals not treated for diabetes. High normal HbA1c levels of 3640 mmol/mol (5.45.8%) were also associated with impaired insulin secretion without marked insulin resistance in Japanese individuals.

    DOI: 10.1111/j.1464-5491.2012.03667.x

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  • Comparison of current BMI and BMI histories to screen for undiagnosed diabetes in Japanese men: Toranomon Hospital Health Management Center Study

    S. Yoshizawa, Y. Heianza, C. Horikawa, S. Hara, K. Saito, S. Kodama, S. D. Hsieh, H. Tsuji, N. Yamada, Y. Arase, H. Sone

    DIABETOLOGIA   55   S136 - S137   2012年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • Development and evaluation of screening score for detecting undiagnosed diabetes and estimating absolute risk of future type 2 diabetes: TOPICS

    Y. Heianza, S. Hara, S. Yoshizawa, S. Kodama, K. Saito, S. D. Hsieh, C. Horikawa, H. Tsuji, N. Yamada, Y. Arase, H. Sone

    DIABETOLOGIA   55   S358 - S358   2012年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • Association between pulse pressure and cardiovascular risk in diabetes mellitus: a meta-analysis

    C. Horikawa, S. Kodama, Y. Heianza, S. Yoshizawa, K. Fujihara, S. Tanaka, K. T. Iida, Y. Yachi, Y. Ohashi, H. Sone

    DIABETOLOGIA   55   S504 - S504   2012年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • 成人期の体重増加と2型糖尿病発症(T2DM)との関連性のメタ解析

    児玉 暁, 堀川 千嘉, 田中 司朗, 藤原 和哉, 由澤 咲子, 平澤 玲子, 伊部 陽子, 大橋 靖雄, 曽根 博仁

    肥満研究   18 ( Suppl. )   170 - 170   2012年9月

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    記述言語:日本語   出版者・発行元:(一社)日本肥満学会  

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  • 大学生に対する多角的栄養教育プログラムの構築

    伊部陽子, 平安座依子, 飯島和子, 宮川八平, 堀口祐子, 水庭真紀子, 三橋典代, 深谷美架, 児玉暁, 曽根博仁

    Campus Health   49 ( 4 )   83 - 83   2012年9月

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    記述言語:日本語   出版者・発行元:(公社)全国大学保健管理協会  

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  • メタアナリシスへの参加経験 7)論文ベースのメタアナリシスをする際の留意点

    児玉暁, 田中司朗, 大橋靖雄, 曽根博仁

    動脈硬化予防   11 ( 2 )   43 - 52   2012年7月

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    記述言語:日本語  

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  • 未診断糖尿病の検出には現在の体重より過去の最大体重の方が有効である。

    児玉暁, 由澤咲子, 平安座依子, 齋藤和美, 辻裕之, 謝勲東, 荒瀬康司, 原茂子, 曽根博仁

    人間ドック   27 ( 2 )   338 - 338   2012年7月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • 人間ドックの上部消化管内視鏡検査で発見されたHelicobacter Pylori陰性胃癌の2例

    小川 恭子, 橋本 光代, 奥田 近夫, 山本 敬, 天川 和久, 大本 由樹, 児玉 暁, 辻 裕之, 原 茂子, 荒瀬 康司

    人間ドック   27 ( 2 )   411 - 411   2012年7月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • 【メタアナリシスの意義-臨床にどういう影響を与えたか-】 メタアナリシスへの参加経験 論文ベースのメタアナリシスをする際の留意点

    児玉 暁, 田中 司朗, 大橋 靖雄, 曽根 博仁

    動脈硬化予防   11 ( 2 )   43 - 52   2012年7月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

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  • Relationship Between Obstructive Sleep Apnea and Diabetes Risk-A Meta-Analysis

    Kazuya Fujihara, Satoru Kodama, Chika Horikawa, Yoriko Heianza, Ayumi Sugawara, Miho Maki, Yoko Yachi, Hitoshi Shimano, Kazumi Saito, Hirohito Sone

    DIABETES   61   A5 - A5   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Effectiveness of Non-Diagnostic Levels of HbA1C or Fasting Plasma Glucose for Diagnosing and Predicting Diabetes Mellitus: Meta-Analysis

    Chika Horikawa, Satoru Kodama, Ryoko Tajima, Kazuya Fujihara, Sakiko Yoshizawa, Yoko Ibe, Reiko Hirasawa, Hitoshi Shimano, Hirohito Sone

    DIABETES   61   A366 - A366   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • A Meta-Analysis of the Quantitative Relationship Between Fat Intake and Incident DM

    Ryoko Tajima, Satoru Kodama, Chika Horikawa, Yoko Yachi, Ayumi Sugawara, Yoriko Heianza, Reiko Hirasawa, Kazuya Fujiwara, Kazumi Saitou, Kaoruko Iida, Hirohito Sone

    DIABETES   61   A190 - A191   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Physical Activity and Lower Risk of All-Cause Death and Cardiovascular Disease in Diabetes: A Meta-Analysis

    Satoru Kodama, Chika Horikawa, Ryoko Tajima, Yoriko Heianza, Ayumi Sugawara, Miho Maki, Yoko Yachi, Kaoruko T. Iida, Kazumi Saito, Hirohito Sone

    DIABETES   61   A40 - A41   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Relationship between Dairy Intake and Risk of Metabolic Syndrome: A Meta-Analysis

    Chika Horikawa, Satoru Kodama, Yoriko Heianza, Ayumi Sugawara, Miho Maki, Sakiko Yoshizawa, Yoko Yachi, Kazumi Saito, Hirohito Sone

    DIABETES   61   A514 - A514   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Both Lifetime Maximum BMI and BMI Change Since Age 20 Years to Maximum Were Strongly Associated With having Undiagnosed Diabetes in Japanese Women: Toranomon Hospital Health Management Center Study

    Sakiko Yoshizawa, Yoriko Heianza, Yasuji Arase, Hiroshi Tsuji, Kazumi Saito, Shiun Dong Hsieh, Satoru Kodama, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

    DIABETES   61   A512 - A512   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Prediction of Incident Diabetes by Measurements of both HbA1C and Fasting Plasma Glucose in Comparison With Use of HbA1c or FPG Alone: A Meta-Analysis

    Satoru Kodama, Chika Horikawa, Ryoko Tajima, Kazuya Fujihara, Sakiko Yoshizawa, Yoko Ibe, Reiko Hirasawa, Hitoshi Shimano, Kazumi Saito, Hirohito Sone

    DIABETES   61   A368 - A368   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Quality and Accuracy of Internet Information Concerning a Healthy Diet

    Reiko Hirasawa, Ayumi Sugawara, Kazumi Saito, Satoru Kodama, Yoko Yachi, Sakiko Yoshizawa, Chika Horikawa, Yoriko Heianza, Yoko Ibe, Hirohito Sone

    DIABETES   61   A175 - A175   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • New Risk Score for Predicting 5-Year Incidence of Type 2 Diabetes in Japan: The Toranomon Hospital Health Management Center Study

    Yoriko Heianza, Yasuji Arase, Hiroshi Tsuji, Sakiko Yoshizawa, Kazumi Saito, Shiun Dong Hsieh, Satoru Kodama, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

    DIABETES   61   A81 - A81   2012年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • 糖尿病診断および予測能におけるグリコヘモグロビンA1cと空腹時血糖のメタ解析

    児玉 暁, 堀川 千嘉, 平安座 依子, 菅原 歩美, 平澤 玲子, 谷内 洋子, 齋藤 和美, 曽根 博仁, 田中 司朗, 大橋 靖雄

    成人病と生活習慣病   42 ( 5 )   621 - 621   2012年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 2型糖尿病発症予測に最適なHbA1cと空腹時血糖値の閾値の組み合わせの検討 TOPICS

    平安座 依子, 山田 信博, 齋藤 和美, 児玉 暁, 曽根 博仁, 原 茂子, 謝 勲東, 辻 裕之, 荒瀬 康司

    成人病と生活習慣病   42 ( 5 )   621 - 622   2012年5月

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  • 健常妊婦における低出生体重児出産リスク因子の検討(TWC Study)

    谷内 洋子, 菅原 歩美, 児玉 暁, 齋藤 和美, 曽根 博仁, 田中 康弘, 松岡 隆, 西端 泉, 安原 眞知子, 小林 香織

    成人病と生活習慣病   42 ( 5 )   604 - 605   2012年5月

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  • 2型糖尿病発症前のHbA1c値と空腹時血糖値の変化に関する大規模縦断的検討

    平安座 依子, 藤原 和哉, 山田 信博, 齋藤 和美, 児玉 暁, 曽根 博仁, 荒瀬 康司, 辻 裕之, 謝 勲東, 原 茂子

    成人病と生活習慣病   42 ( 5 )   602 - 603   2012年5月

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  • HbA1cを導入した新しい2型糖尿病予測スコアリングシステムの開発

    平安座 依子, 藤原 和哉, 堀川 千嘉, 谷内 洋子, 山田 信博, 児玉 暁, 曽根 博仁, 謝 勲東, 原 茂子, 辻 裕之, 荒瀬 康司

    成人病と生活習慣病   42 ( 5 )   603 - 603   2012年5月

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  • "Healthy diet"に関する国際的ウェブ情報のクオリティの検証

    平澤 玲子, 谷内 洋子, 伊部 陽子, 由澤 咲子, 堀川 千嘉, 斉藤 あき, 平安座 依子, 菅原 歩美, 戸塚 久美子, 齋藤 和美, 児玉 暁, 曽根 博仁

    成人病と生活習慣病   42 ( 5 )   606 - 606   2012年5月

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  • 妊娠中期耐糖能スクリーニングは低出生体重児出産を予測する方法として有用である(TWC Study)

    谷内洋子, 田中康弘, 西端泉, 菅原歩美, 松岡隆, 島野仁, 児玉暁, 齋藤和美, 曽根博仁

    糖尿病   55 ( Supplement 1 )   S.186 - 186   2012年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 生涯最大BMIならびに20歳から生涯最大までのBMI変化はいずれも2型糖尿病と強く関連する:TOPICS

    由澤咲子, 平安座依子, 荒瀬康司, 齋藤和美, 辻裕之, 児玉暁, 謝勲東, 島野仁, 山田信博, 原茂子, 曽根博仁

    糖尿病   55 ( Supplement 1 )   S.306   2012年4月

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  • HbA1cを導入した新しい2型糖尿病リスクスコアの開発:The Toranomon Hospital Health Management Center Study(TOPICS)

    平安座依子, 原茂子, 齋藤和美, 藤原和哉, 辻裕之, 児玉暁, 謝勲東, 島野仁, 荒瀬康司, 山田信博, 曽根博仁

    糖尿病   55 ( Supplement 1 )   S.214 - 214   2012年4月

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  • 高脂肪食と糖尿病発症リスクの関連性についてのメタ解析

    田島諒子, 児玉暁, 藤原和哉, 平安座依子, 菅原歩美, 平澤玲子, 谷内洋子, 齋藤和美, 飯田薫子, 曽根博仁

    糖尿病   55 ( Supplement 1 )   S.214 - 214   2012年4月

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  • 2型糖尿病発症に至るまでのHbA1c値と空腹時血糖値の長期変化に関する検討:TOPICS

    原茂子, 平安座依子, 齋藤和美, 藤原和哉, 辻裕之, 児玉暁, 謝勲東, 島野仁, 荒瀬康司, 山田信博, 曽根博仁

    糖尿病   55 ( Supplement 1 )   S.214 - 214   2012年4月

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  • フラミンガムリスクスコア,UKPDSリスクエンジン,max‐IMT,LDL/HDL比による冠動脈病変予測能に関する検討

    藤原和哉, 鈴木浩明, 佐藤明, 大崎芳典, 尾本美代子, 豊崎晶子, 平安座依子, 児玉暁, 斎藤和美, 小林和人, 矢藤繁, 高橋昭光, 山田信博, 曽根博仁, 島野仁

    糖尿病   55 ( Supplement 1 )   S.180 - 180   2012年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病と難聴の関連性についてのメタ解析

    堀川 千嘉, 児玉 暁, 藤原 和哉, 平安座 依子, 菅原 歩美, 平澤 玲子, 谷内 洋子, 齋藤 和美, 曽根 博仁

    糖尿病   55 ( Suppl.1 )   S - 358   2012年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 生涯最大BMIならびに20歳から生涯最大までのBMI変化はいずれも2型糖尿病と強く関連する

    由澤 咲子, 平安座 依子, 荒瀬 康司, 齋藤 和美, 辻 裕之, 児玉 暁, 謝 勲東, 島野 仁, 山田 信博, 原 茂子, 曽根 博仁

    糖尿病   55 ( Suppl.1 )   S - 306   2012年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 日本人高齢者における各種肥満度指数と心血管疾患危険因子との関連~SAT 194

    叔びょう, 齋藤和美, 児玉暁, 田辺解, 村上晴香, 飯田薫子, 田中喜代次, 鰺坂隆一, 久野譜也, 曽根博仁

    日本未病システム学会雑誌   18 ( 1 )   32 - 37   2012年2月

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    記述言語:日本語   出版者・発行元:(一社)日本未病システム学会  

    肥満を表す指標は多くあるが、どの指標が最も強く心血管疾患危険因子と関連するかは人種や年齢により異なる可能性が指摘されている。日本人高齢者における、体格指数(Body mass index(BMI)(kg/m2))、ウエスト(WC)(cm)、ウエストヒップ比(WHR)、ウエスト身長比(WHtR)、CTによる腹部脂肪面積(総脂肪面積(total fat area;TFA)、内臓脂肪面積(visceral fat area;VFA)、皮下脂肪面積(subcutaneous fat area;SFA)、単位はいずれも(cm2)と心血管疾患危険因子(高血圧、糖尿病、低HDLコレステロール血症、高トリグリセリド(TG)血症)との関連を検討した。運動教室に参加した251名の高齢者の心血管疾患危険因子の保有状況を調査し、心血管疾患危険因子の保有数別に、各肥満指標の平均値を比較した。また、各肥満指標を四分位にした際の、心血管疾患危険因子2個以上の保有頻度の差異を検討した。さらに各指標のうち、心血管疾患危険因子2個以上の保有に最も強く関連する因子をロジスティック回帰分析により検討し、強く関連した因子の閾値を求めた。検討した各肥満指標の平均値は、心血管疾患危険因子の保有個数により異なっていた。各肥満指標は高いほど心血管疾患危険因子を2個以上保有との関連が強く、肥満指標のうち、WCが心血管疾患危険因子2個以上の保有に最も強く関連した。WCの閾値は男性で85.5cm(感度66%、特異度69%)、女性で75.5cm(感度80%、特異度55%)であった。(著者抄録)

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  • 日本人高齢者における高感度CRPとメタボリックシンドロームおよび肥満との関連~SAT 195

    叔びょう, 齋藤和美, 児玉暁, 田辺解, 村上晴香, 飯田薫子, 田中喜代次, 鰺坂隆一, 久野譜也, 曽根博仁

    日本未病システム学会雑誌   18 ( 1 )   38 - 43   2012年2月

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    記述言語:日本語   出版者・発行元:(一社)日本未病システム学会  

    [目的]日本人高齢者において、高感度CRP(high sensitivity C-reactive protein、hsCRP)濃度とメタボリックシンドローム(Metabolic Syndrome、MetS)構成因子および肥満指標との関係、MetSに対するhsCRP濃度のカットオフ値について検討する。[対象と方法]高齢者向け運動教室参加者251名(うち男性91名、平均年齢69.5±5.2歳)において、体格指数(BMI)、腹囲、腹部総脂肪面積、腹部皮下脂肪面積、内臓脂肪面積、血圧を測定し、採血検査を実施した。高血圧・糖尿病・脂質異常症の病歴を調査し、修正AHA/NHLBI基準によるMetS構成因子(糖尿病、高血圧、低HDLコレステロール血症、高トリグリセリド(triglyceride、TG)血圧、肥満(腹囲により判定))の保有状況について調査した。[結果]hsCRP値で四分位分割した際、最高四分位群の最低四分位群に対するMetS、および各MetS因子(糖尿病、高血圧、低HDLコレステロール血症、高TG血症、肥満)の保有リスクのハザード比(95%信頼区間)はそれぞれ、3.3(1.5-7.3)、1.8(0.8-3.8)、0.9(0.4-2.4)、1.7(0.7-4.2)、2.0(0.8-5.1)、3.5(1.6-7.9)であった。hsCRP濃度とBMI、腹囲、総脂肪量、内臓脂肪量、皮下脂肪量との相関係数(R)は、それぞれ0.26、0.21、0.17、0.18、0.12であり、皮下脂肪量以外との相関関係は統計学的に有意であった。MetSに対して最適と思われるhsCRP濃度のカットオフ値は、0.44mg/L(感度60%、特異度59%)であった。(著者抄録)

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  • 糖尿病患者の身体活動量と総死亡,心血管疾患発症リスクの関連性のメタ解析

    児玉暁, 藤原和哉, 齋藤和美, 曽根博仁

    日本内科学会雑誌   101 ( Suppl. )   290 - 290   2012年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • 異なる空腹時血糖値異常とHbA1c高値の判定基準を用いた2型糖尿病予測スクリーニング精度の比較:TOPICS

    平安座依子, 原茂子, 謝勲東, 児玉暁, 辻裕之, 藤原和哉, 由澤咲子, 伊部陽子, 齋藤和美, 山田信博, 荒瀬康司, 曽根博仁

    J Epidemiol   22 ( Supplement 1 )   122   2012年1月

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  • 成人における糖尿病と難聴の関連性:メタアナリシスにおける評価

    堀川千嘉, 児玉暁, 菅原歩美, 平安座依子, 由澤咲子, 齋藤あき, 伊部陽子, 平澤玲子, 谷内洋子, 齋藤和美, 曽根博仁

    J Epidemiol   22 ( Supplement 1 )   121   2012年1月

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  • 2型糖尿病発症10年間のHbA1c値の変化:TOPICS

    平安座依子, 荒瀬康司, 辻裕之, 齋藤和美, 藤原和哉, 謝勲東, 児玉暁, 山田信博, 原茂子, 曽根博仁

    Journal of Epidemiology   22 ( Supplement 1 )   122   2012年1月

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  • 糖尿病診断および予測能におけるグリコヘモグロビンA1cと空腹時血糖のメタ解析

    児玉 暁, 堀川 千嘉, 平安座 依子, 菅原 歩美, 平澤 玲子, 谷内 洋子, 齋藤 和美, 田中 司朗, 大橋 靖雄, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   38   74 - 74   2012年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 2型糖尿病発症予測に最適なHbA1cと空腹時血糖値の閾値の組み合わせの検討:TOPICS

    平安座依子, 原茂子, 謝勲東, 齋藤和美, 辻裕之, 菅原歩美, 齋藤あき, 児玉暁, 荒瀬康司, 山田信博, 曽根博仁

    日本成人病(生活習慣病)学会会誌   38   75 - 75   2012年1月

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  • HbA1cを導入した新しい2型糖尿病予測スコアリングシステムの開発

    平安座 依子, 謝 勲東, 原 茂子, 辻 裕之, 藤原 和哉, 堀川 千嘉, 谷内 洋子, 児玉 暁, 山田 信博, 荒瀬 康司, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   38   54 - 54   2012年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • "Healthy diet"に関する国際的ウェブ情報のクオリティの検証

    平澤 玲子, 谷内 洋子, 伊部 陽子, 由澤 咲子, 堀川 千嘉, 斉藤 あき, 平安座 依子, 菅原 歩美, 戸塚 久美子, 齋藤 和美, 児玉 暁, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   38   58 - 58   2012年1月

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  • 2型糖尿病発症前のHbA1c値と空腹時血糖値の変化に関する大規模縦断的検討

    平安座依子, 荒瀬康司, 辻裕之, 齋藤和美, 藤原和哉, 謝勲東, 児玉暁, 山田信博, 原茂子, 曽根博仁

    日本成人病(生活習慣病)学会会誌   38   53 - 53   2012年1月

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  • 健常妊婦における低出生体重児出産リスク因子の検討(TWC Study)

    谷内洋子, 田中康弘, 西端泉, 菅原歩美, 安原眞知子, 小林香織, 松岡隆, 児玉暁, 齋藤和美, 曽根博仁

    日本成人病(生活習慣病)学会会誌   38   56 - 56   2012年1月

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  • 動脈硬化と運動・身体活動―予防・改善のための取り組み―疫学研究 運動と動脈硬化の疫学

    児玉暁, 曽根博仁

    臨床スポーツ医学   28 ( 12 )   1311 - 1316   2011年12月

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    記述言語:日本語   出版者・発行元:(株)文光堂  

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    臨床スポーツ医学   28 ( 12 )   1311 - 1316   2011年12月

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    記述言語:日本語   出版者・発行元:文光堂  

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  • 生活習慣病の臨床エビデンス 第28回 Webを使用した減量指導効果のエビデンス

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    記述言語:日本語   出版者・発行元:(株)丹水社  

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  • 20歳時BMIは妊娠糖尿病発症を予測する指標として有用である(Tanaka Women’s Clinic Study)

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病・妊娠学会  

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  • 胴身長比(Waist-to-stature ratio:WSR)と2型糖尿病発症(T2DM)との関連性のメタ解析

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    記述言語:日本語   出版者・発行元:(一社)日本肥満学会  

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  • Potential impact of elevated HbA(1c) and impaired fasting glucose on population for predicting risk of diabetes: the Toranomon Hospital Health Management Center Study

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • Screening using various cutoffs of HbA(1c) and impaired fasting plasma glucose for predicting future diabetes: the Toranomon hospital health management center study

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    DIABETOLOGIA   54   S142 - S142   2011年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • Low BMI at age 20 years predicts gestational diabetes independent of BMI in early pregnancy: Tanaka Women's Clinic Study

    Y. Yachi, C. Horikawa, Y. Heianza, A. Sugawara, A. Saito, K. Fujiwara, I. Nishibata, M. Yasuhara, K. Kobayashi, S. Kodama, K. Saito, Y. Tanaka, H. Sone

    DIABETOLOGIA   54   S479 - S479   2011年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • 血清コレステロール値と無症候性脳梗塞の関連―横断的検討

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    日本老年医学会雑誌   48 ( 4 )   404 - 404   2011年7月

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    記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

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  • 採血を用いない未診断糖尿病患者簡易発見法の妥当性の検討

    児玉暁, 平安座依子, 原茂子, 辻裕之, 謝勲東, 荒瀬康司, 曽根博仁

    人間ドック   26 ( 2 )   410 - 410   2011年7月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • 大脳深部白質高信号所見(DSWMH)の臨床的意義 大きさおよび個数とIMTmax値との関連

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    日本老年医学会雑誌   48 ( 4 )   404 - 404   2011年7月

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  • 大脳深部白質高信号所見(DSWMH)の臨床的意義 大きさ個数と年齢との関連

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    日本老年医学会雑誌   48 ( 4 )   404 - 404   2011年7月

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    記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

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  • Diabetes and Risk of Hearing Impairment: A Meta-Analysis

    Chika Horikawa, Satoru Kodama, Yoriko Heianza, Aki Saito, Reiko Hira Sawa, Ayumi Sugawara, Kumiko Totsuka, Miho Maki, Kazumi Saito, Hirohito Sone

    DIABETES   60   A118 - A118   2011年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Is the Waist-to-Stature Ratio a Better Predictor Than Other Anthropometric Indicators To Predict Future Diabetes Risk? A Meta-Analysis

    Satoru Kodama, Chika Horikawa, Yoriko Heianza, Ayumi Sugawara, Yoko Ibe, Yoko Yachi, Miho Maki, Miao Shu, Kazumi Saito, Hirohito Sone

    DIABETES   60   A514 - A514   2011年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS)

    Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

    DIABETES   60   A235 - A235   2011年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS)

    Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

    DIABETES   60   A235 - A235   2011年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Alcohol Consumption and Risk of Atrial Fibrillation Reply

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    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   57 ( 25 )   2545 - 2546   2011年6月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    DOI: 10.1016/j.jacc.2011.02.035

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  • 産後のうつ症状と妊娠期の生活習慣との関連(Tanaka Women's Clinic Study)

    穴迫 唯衣, 谷内 洋子, 児玉 暁, 齋藤 和美, 曽根 博仁, 鈴木 恵美子, 近藤 和雄, 赤松 利恵, 飯田 薫子, 田中 康弘, 西端 泉, 安原 眞知子, 小林 香織

    成人病と生活習慣病   41 ( 5 )   622 - 623   2011年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • HbA1cと空腹時血糖値それぞれにより糖尿病型と判定された者の特徴 TOPICS

    平安座 依子, 齋藤 和美, 藤原 和哉, 児玉 暁, 山田 信博, 曽根 博仁, 平安座 依子, 原 茂子, 齋藤 和美, 辻 裕之, 児玉 暁, 謝 勲東, 荒瀬 康司, 小坂 樹徳, 曽根 博仁, 原 茂子, 辻 裕之, 謝 勲東, 荒瀬 康司, 小坂 樹徳

    成人病と生活習慣病   41 ( 5 )   600 - 601   2011年5月

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  • 採血不要の臨床指標による未診断糖尿病スクリーニングのための基礎的検討 TOPICS

    平安座 依子, 齋藤 和美, 児玉 暁, 山田 信博, 曽根 博仁, 原 茂子, 齋藤 和美, 辻 裕之, 謝 勲東, 荒瀬 康司, 小坂 樹徳

    成人病と生活習慣病   41 ( 5 )   602 - 603   2011年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 脂質異常症診断基準の臨床的意義 男性における体重管理指標との関連

    阿隅 美保子, 齋藤 和美, 児玉 暁, 曽根 博仁, 飯田 薫子, 鈴木 恵美子, 近藤 和雄, 山口 龍生, 松井 博滋, 宮澤 英充

    成人病と生活習慣病   41 ( 5 )   598 - 599   2011年5月

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  • 過去の体重歴は未診断糖尿病や前糖尿病状態を発見する指標として有用である TOPICS

    平安座 依子, 齋藤 和美, 児玉 暁, 山田 信博, 曽根 博仁, 原 茂子, 齋藤 和美, 辻 裕之, 児玉 暁, 謝 勲東, 荒瀬 康司, 小坂 樹徳, 曽根 博仁, 原 茂子, 辻 裕之

    成人病と生活習慣病   41 ( 5 )   599 - 599   2011年5月

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  • 卵の摂取量と心血管疾患リスクとの関連

    堀川 千嘉, 児玉 暁, 齋藤 あき, 平安座 依子, 西垣 結佳子, 穴迫 唯衣, 伊部 陽子, 平澤 玲子, 谷内 陽子, 齋藤 和美, 曽根 博仁

    成人病と生活習慣病   41 ( 5 )   597 - 597   2011年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 喫煙状況と無症候性脳梗塞との関連性 脳ドック受診者における横断的検討

    阿隅 美保子, 齋藤 和美, 児玉 暁, 曽根 博仁, 飯田 薫子, 鈴木 恵美子, 近藤 和雄, 山口 龍生, 松井 博滋, 宮澤 英充

    成人病と生活習慣病   41 ( 5 )   608 - 609   2011年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 二十歳時から妊娠時までのBMI変化と妊娠糖尿病発症リスクとの関連(TWC Study)

    谷内洋子, 田中康弘, 穴迫唯衣, 菅原歩美, 戸塚久美子, 赤松利恵, 近藤和雄, 鈴木恵美子, 飯田薫子, 児玉暁, 齋藤和美, 曽根博仁

    日本栄養・食糧学会大会講演要旨集   65th   109 - 109   2011年4月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • CT coronary angiography(CTA)による冠動脈不安定プラーク(VP)と関連する臨床指標に関する検討

    藤原和哉, 鈴木浩明, 佐藤明, 大崎芳典, 尾本美代子, 豊崎晶子, 平安座依子, 児玉暁, 斎藤和美, 小林和人, 矢藤繁, 高橋昭光, 山田信博, 曽根博仁, 島野仁

    糖尿病   54 ( Supplement 1 )   S.220 - 220   2011年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • HbA1cと空腹時血糖値による糖尿病型の判定基準と臨床指標の比較(TOPICS)

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    糖尿病   54 ( Supplement 1 )   S.102 - 102   2011年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 採血不要の臨床指標による未診断糖尿病予測スコアリングシステムの開発(TOPICS)

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    糖尿病   54 ( Supplement 1 )   S.101 - 101   2011年4月

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  • 妊娠時までのBMI変化と妊娠糖尿病発症リスクとの関連(TWC Study)

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 生涯最大体重や20歳時の体重はその後の未診断糖尿病や前糖尿病状態の発症と関連する(TOPICS)

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    日本栄養・食糧学会大会講演要旨集   65th ( Supplement 1 )   108 - 108   2011年4月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • HbA1cとFPGによる糖代謝異常評価とその後の糖尿病発症リスク(TOPICS)

    原茂子, 平安座依子, 齋藤和美, 辻裕之, 児玉暁, 謝勲東, 島野仁, 荒瀬康司, 山田信博, 小坂樹徳, 曽根博仁

    糖尿病   54 ( Supplement 1 )   S.202 - 202   2011年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 日本人男性における喫煙状況と無症候性脳梗塞の関連性―喫煙指数を用いた横断的検討

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    日本栄養・食糧学会大会講演要旨集   65th   152 - 152   2011年4月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • 2型糖尿病患者における、糖・脂質摂取比(C/F比)が糖・脂質代謝に及ぼす影響のメタアナリシス

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    日本栄養・食糧学会大会講演要旨集   65回   196 - 196   2011年4月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • インターネットを用いた生活習慣改善教育における、肥満改善効果の検討 メタ解析による評価

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    日本栄養・食糧学会大会講演要旨集   65回   232 - 232   2011年4月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • 経口ブドウ糖負荷前・負荷後血糖の心血管疾患リスクの量的関係の解析(メタアナリシス)

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    糖尿病   54 ( Suppl.1 )   S - 219   2011年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 生涯最大体重や20歳時の体重はその後の未診断糖尿病や前糖尿病状態の発症と関連する(TOPICS)

    齋藤 あき, 平安座 依子, 原 茂子, 齋藤 和美, 辻 裕之, 児玉 暁, 近藤 和雄, 荒瀬 康司, 山田 信博, 小坂 樹徳, 曽根 博仁

    糖尿病   54 ( Suppl.1 )   S - 108   2011年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Low serum potassium levels and risk of type 2 diabetes: the Toranomon Hospital Health Management Center Study 1 (TOPICS 1)

    Y. Heianza, S. Hara, Y. Arase, K. Saito, K. Totsuka, H. Tsuji, S. Kodama, S. D. Hsieh, N. Yamada, K. Kosaka, H. Sone

    DIABETOLOGIA   54 ( 4 )   762 - 766   2011年4月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Evidence has suggested that low serum potassium concentrations decrease insulin secretion, leading to glucose intolerance, and that hypokalaemia induced by diuretics increases the risk for diabetes in hypertensive individuals. However, no prospective study has investigated the association between serum potassium and the development of type 2 diabetes in a healthy cohort comprised of Asian individuals not being administered antihypertensive medications. This study aimed to investigate whether low serum potassium is associated with increased risk of type 2 diabetes in apparently healthy Japanese men.
    We followed 4,409 Japanese men with no history of diabetes, use of antihypertensives, renal dysfunction or liver dysfunction (mean +/- SD age, 48.4 +/- 8.4 years). Cox proportional hazards regression was used to estimate HRs for incident diabetes (fasting plasma glucose level a parts per thousand yen7.0 mmol/l, HbA(1c) a parts per thousand yenaEuro parts per thousand 6.5% or self-reported) including serum potassium concentration as either a categorical or a continuous variable.
    During a 5 year follow-up, 250 individuals developed type 2 diabetes. The lowest tertile of serum potassium (2.8-3.9 mmol/l) was independently associated with the development of diabetes after adjustment for known predictors (HR 1.57 [95% CI, 1.15-2.15]) compared with the highest tertile (4.2-5.4 mmol/l). Every 0.5 mmol/l lower increment in the baseline serum potassium level was associated with a 45% (12-87%) increased risk of diabetes.
    Mild to moderately low serum potassium levels, within the normal range and without frank hypokalaemia, could be predictive of type 2 diabetes in apparently healthy Japanese men.

    DOI: 10.1007/s00125-010-2029-9

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  • メタ解析からみた卵摂取と心血管疾患リスク上昇との関連性の考察

    児玉暁, 齋藤和美, 藤原和哉, 小林和人, 矢藤繁, 高橋昭光, 鈴木浩明, 島野仁, 山田信博, 曽根博仁

    日本内科学会雑誌   100 ( Suppl. )   208 - 208   2011年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • 生活習慣病の臨床エビデンス 第23回 飲酒と心房細動リスクの関連

    児玉暁, 曽根博仁

    肥満と糖尿病   10 ( 1 )   144 - 147   2011年1月

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    記述言語:日本語   出版者・発行元:(株)丹水社  

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  • 産後のうつ症状と妊娠期の生活習慣との関連(Tanaka Women’s Clinic Study)

    穴迫唯衣, 田中康弘, 谷内洋子, 西端泉, 安原眞知子, 小林香織, 鈴木恵美子, 近藤和雄, 赤松利恵, 飯田薫子, 児玉暁, 齋藤和美, 曽根博仁

    日本成人病(生活習慣病)学会会誌   37   82 - 82   2011年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • HbA1cと空腹時血糖値それぞれにより糖尿病型と判定された者の特徴:TOPICS

    平安座依子, 原茂子, 齋藤和美, 藤原和哉, 辻裕之, 児玉暁, 謝勲東, 荒瀬康司, 山田信博, 小坂樹徳, 曽根博仁

    日本成人病(生活習慣病)学会会誌   37   57 - 57   2011年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 喫煙状況と無症候性脳梗塞との関連性―脳ドック受診者における横断的検討

    阿隅美保子, 山口龍生, 齋藤和美, 児玉暁, 松井博滋, 宮澤英充, 飯田薫子, 鈴木恵美子, 近藤和雄, 曽根博仁

    日本成人病(生活習慣病)学会会誌   37   66 - 66   2011年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 卵の摂取量と心血管疾患リスクとの関連

    堀川 千嘉, 児玉 暁, 齋藤 あき, 平安座 依子, 西垣 結佳子, 穴迫 唯衣, 伊部 陽子, 平澤 玲子, 谷内 陽子, 齋藤 和美, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   37   53 - 53   2011年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 採血不要の臨床指標による未診断糖尿病スクリーニングのための基礎的検討:TOPICS

    平安座依子, 原茂子, 齋藤和美, 辻裕之, 児玉暁, 謝勲東, 荒瀬康司, 山田信博, 小坂樹徳, 曽根博仁

    日本成人病(生活習慣病)学会会誌   37   59 - 59   2011年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 脂質異常症診断基準の臨床的意義―男性における体重管理指標との関連

    阿隅美保子, 山口龍生, 齋藤和美, 児玉暁, 松井博滋, 宮澤英充, 飯田薫子, 鈴木恵美子, 近藤和雄, 曽根博仁

    日本成人病(生活習慣病)学会会誌   37   55 - 55   2011年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 過去の体重歴は未診断糖尿病や前糖尿病状態を発見する指標として有用である TOPICS

    平安座 依子, 原 茂子, 齋藤 和美, 辻 裕之, 児玉 暁, 謝 勲東, 荒瀬 康司, 山田 信博, 小坂 樹徳, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   37   55 - 55   2011年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 日本人糖尿病患者の特徴と病態に関する臨床疫学的研究

    曽根 博仁

    糖尿病   53 ( 11 )   791 - 794   2010年11月

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    記述言語:日本語   出版者・発行元:日本糖尿病学会  

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    その他リンク: http://search.jamas.or.jp/link/ui/2011062837

  • 今なぜ,トータル血管マネージメントが必要なのか 血管マネージメント 3)動脈硬化の抑制および心血管疾患の予防を目ざした生活習慣改善のエビデンス

    児玉暁, 曽根博仁

    Mebio   27 ( 10 )   46 - 55   2010年10月

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    記述言語:日本語  

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  • 大学生の食物摂取状況および食に関する知識・態度・行動等の実態調査

    伊部陽子, 飯島和子, 平安座依子, 穴迫唯衣, 齋藤あき, 齋藤和美, 児玉暁, 曽根博仁

    栄養学雑誌   68 ( 5 Supplement )   232   2010年9月

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  • 「地中海食」に関するインターネット情報のクオリティ評価

    平澤玲子, 西垣結佳子, 平安座依子, 伊部陽子, 飯田薫子, 近藤和雄, 島野仁, 児玉暁, 斎藤和美, 曽根博仁

    栄養学雑誌   68 ( 5 Supplement )   305   2010年9月

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  • アジア人における朝食欠食と肥満リスクの関係のメタ分析

    堀川千嘉, 児玉暁, 西垣結佳子, 齋藤あき, 穴迫唯衣, 平安座依子, 平澤玲子, 島野仁, 齋藤和美, 曽根博仁

    栄養学雑誌   68 ( 5 Supplement )   305   2010年9月

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  • インターネットによる生活習慣指導の肥満に対する効果の定量的検討

    児玉 暁, 斉藤 和美, 堀川 千嘉, 谷口 絵里香, 斉藤 あき, 平安座 依子, 西垣 結佳子, 穴迫 唯衣, 菅原 歩美, 戸塚 久美子, 平澤 玲子, 阿隅 美保子, 牧 美保, 谷内 洋子, 伊部 陽子, 曽根 博仁

    肥満研究   16 ( Suppl. )   123 - 123   2010年9月

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    記述言語:日本語   出版者・発行元:(一社)日本肥満学会  

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  • 運動基準づくりへの新エビデンス 生活習慣病発症リスクと最大酸素摂取量

    児玉暁, 曽根博仁

    体育の科学   60 ( 6 )   379 - 383   2010年6月

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    記述言語:日本語   出版者・発行元:(株)杏林書院  

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  • 生活習慣病発症リスクと最大酸素摂取量 (特集 運動基準づくりへの新エビデンス)

    児玉 暁, 曽根 博仁

    体育の科学   60 ( 6 )   379 - 383   2010年6月

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    記述言語:日本語   出版者・発行元:杏林書院  

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  • Smoking Cessation Can Prevent the Development of Type 2 Diabetes (T2DM) Independent of a History of Heavy Smoking:Toranomon Hospital Health Management Center Study (TOPICS)

    Yoriko Heianza, Kazumi Saito, Kumiko Totsuka, Chika Horikawa, Satoru Kodama, Shiun Dong Hsieh, Shigeko Hara, Yasuji Arase, Kinori Kosaka, Hirohito Sone

    DIABETES   59   A294 - A294   2010年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • Simple Self-Report Questions on Behavioral or Psychological Symptoms Can Effectively Predict Future Type2 Diabetes (T2DM): Toranomon Hospital Health Management Center Study (TOPICS)

    Yoriko Heianza, Yukako Nishigaki, Kazumi Saito, Kumiko Totsuka, Satoru Kodama, Hiroshi Tsuji, Shigeko Hara, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

    DIABETES   59   A114 - A114   2010年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • インターネットを用いた生活習慣指導の肥満改善効果のメタ解析

    谷口 絵里香, 児玉 暁, 齋藤 和美, 堀川 千嘉, 齋藤 あき, 平安座 依子, 西垣 結佳子, 穴迫 唯衣, 谷内 洋子, 牧 美保, 平澤 玲子, 曽根 博仁, 鈴木 恵美子, 近藤 和雄

    成人病と生活習慣病   40 ( 5 )   546 - 546   2010年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 大脳深部白質高信号所見(DSWMH)の年齢別出現状況と頸動脈硬化との関連

    阿隅 美保子, 山口 龍生, 鶉橋 弘子, 古川 豊, 松井 博滋, 宮澤 英充, 鈴木 恵美子, 近藤 和雄, 福田 寛, 齋藤 和美, 児玉 暁, 曽根 博仁

    成人病と生活習慣病   40 ( 5 )   568 - 568   2010年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • アルコール摂取と心房細動リスクの関連性についてのメタ解析

    児玉 暁, 齋藤 和美, 松坂 賢, 小林 和人, 矢藤 繁, 高橋 昭光, 鈴木 浩明, 島野 仁, 山田 信博, 曽根 博仁

    成人病と生活習慣病   40 ( 5 )   566 - 566   2010年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 無症候性脳梗塞と血清コレステロール値に関する横断的検討

    阿隅 美保子, 山口 龍生, 鶉橋 弘子, 古川 豊, 松井 博滋, 宮澤 英充, 鈴木 恵美子, 近藤 和雄, 福田 寛, 齋藤 和美, 児玉 暁, 曽根 博仁

    成人病と生活習慣病   40 ( 5 )   567 - 567   2010年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 朝食欠食と肥満リスクとの関係に関するメタ解析

    堀川 千嘉, 児玉 暁, 齋藤 和美, 平澤 玲子, 伊部 陽子, 谷内 洋子, 平安座 依子, 斉藤 あき, 菅原 歩美, 戸塚 久美子, 阿隅 美保子, 曽根 博仁, 鈴木 恵美子, 近藤 和雄

    成人病と生活習慣病   40 ( 5 )   546 - 547   2010年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 2型糖尿病患者における診療の主観的説明理解度と心理的ストレスとの関連

    西垣 結佳子, 齋藤 あき, 齋藤 和美, 児玉 暁, 曽根 博仁, 横山 宏樹, 川井 紘一, 大石 まり子, 杉本 英克

    成人病と生活習慣病   40 ( 5 )   550 - 551   2010年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 血清カリウム低値は2型糖尿病発症の新たな独立した危険因子である Toranomon Hospital Health Management Center Study 1(TOPICS-1)

    平安座 依子, 齋藤 和美, 戸塚 久美子, 児玉 暁, 山田 信博, 曽根 博仁, 原 茂子, 荒瀬 康司, 辻 裕之, 謝 勲東, 小坂 樹徳

    成人病と生活習慣病   40 ( 5 )   545 - 545   2010年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 2型糖尿病患者における就寝・起床時刻と血糖コントロールの関連についての探索的検討

    齋藤 あき, 西垣 結佳子, 齋藤 和美, 児玉 暁, 曽根 博仁, 川井 紘一, 大石 まり子, 杉本 英克, 栗林 伸一, 和田 崇子

    成人病と生活習慣病   40 ( 5 )   583 - 583   2010年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 2型糖尿病患者における安静時CVRR低下の発症率

    齋藤和美, 川井紘一, 菅原歩美, 平澤玲子, 本橋しのぶ, 児玉暁, 小林和人, 島野仁, 山田信博, 曽根博仁

    糖尿病   53 ( Supplement 1 )   S.307 - 307   2010年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 低カリウム血症は2型糖尿病発症の新たな独立した危険因子である:Toranomom Hospital Health Management Center Study(TOPICS)

    平安座依子, 原茂子, 荒瀬康司, 齋藤和美, 戸塚久美子, 辻裕之, 児玉暁, 謝勲東, 山田信博, 小坂樹徳, 曽根博仁

    糖尿病   53 ( Supplement 1 )   S.106   2010年4月

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  • 2型糖尿病患者における睡眠時間と糖尿病コントロールとの関連

    齋藤あき, 川井紘一, 柳澤守文, 栗林伸一, 横山宏樹, 杉本英克, 大石まり子, 和田崇子, 屋宜宣治, 宮澤一裕, 岩崎皓一, 新井桂子, 児玉暁, 曽根博仁

    糖尿病   53 ( Supplement 1 )   S.115 - 115   2010年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 低カリウム血症は2型糖尿病発症の新たな独立した危険因子である Toranomon Hospital Health Management Center Study(TOPICS)

    平安座 依子, 原 茂子, 荒瀬 康司, 齋藤 和美, 戸塚 久美子, 辻 裕之, 児玉 暁, 謝 勲東, 山田 信博, 小坂 樹徳, 曽根 博仁

    糖尿病   53 ( Suppl.1 )   S - 106   2010年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 生活習慣病の臨床エビデンス 第18回 2型糖尿病発症関連因子としての尿酸値

    児玉暁, 曽根博仁

    肥満と糖尿病   9 ( 2 )   321 - 323   2010年3月

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    記述言語:日本語   出版者・発行元:(株)丹水社  

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  • 血中尿酸値と2型糖尿病発症の関連についてのメタ解析

    児玉暁, 齋藤和美, 小林和人, 矢藤繁, 高橋昭光, 鈴木浩明, 島野仁, 山田信博, 曽根博仁

    日本内科学会雑誌   99 ( Suppl. )   185 - 185   2010年2月

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  • 大脳深部白質高信号所見(DSWMH)の年齢別出現状況と頸動脈硬化との関連

    阿隅美保子, 山口龍生, 鶉橋弘子, 古川豊, 齋藤和美, 児玉暁, 松井博滋, 宮澤英充, 鈴木恵美子, 近藤和雄, 福田寛, 曽根博仁

    日本成人病(生活習慣病)学会会誌   36   84 - 84   2010年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • アルコール摂取と心房細動リスクの関連性についてのメタ解析

    児玉暁, 斉藤和美, 松坂賢, 小林和人, 矢藤繁, 高橋昭光, 鈴木浩明, 島野仁, 山田信博, 曽根博仁

    日本成人病(生活習慣病)学会会誌   36   82 - 82   2010年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 2型糖尿病患者における診療の説明理解度と心理的ストレスの関連

    西垣結佳子, 齋藤あき, 横山宏樹, 川井紘一, 大石まり子, 杉本英克, 湯原淳良, 屋宜宣治, 齋藤和美, 児玉暁, 曽根博仁

    日本成人病(生活習慣病)学会会誌   36   66 - 66   2010年1月

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  • 低カリウム血症は2型糖尿病発症の新たな独立した危険因子である

    平安座依子, 齋藤和美, 児玉暁, 戸塚久美子, 辻裕之, 謝勲東, 小坂樹徳, 山田信博, 原茂子, 荒瀬康司, 曽根博仁

    日本成人病(生活習慣病)学会会誌   36   60 - 60   2010年1月

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  • 無症候性脳梗塞と血清コレステロール値に関する横断的検討

    阿隅美保子, 山口龍生, 鶉橋弘子, 古川豊, 齋藤和美, 児玉暁, 松井博滋, 宮澤英充, 鈴木恵美子, 近藤和雄, 福田寛, 曽根博仁

    日本成人病(生活習慣病)学会会誌   36   84 - 84   2010年1月

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  • インターネットを用いた生活習慣指導の肥満改善効果のメタ解析

    谷口 絵里香, 児玉 暁, 齋藤 和美, 堀川 千嘉, 齋藤 あき, 平安座 依子, 西垣 結佳子, 穴迫 唯衣, 谷内 洋子, 牧 美保, 平澤 玲子, 鈴木 恵美子, 近藤 和雄, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   36   61 - 61   2010年1月

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  • 朝食欠食と肥満リスクのメタ解析

    堀川 千嘉, 児玉 暁, 斉藤 和美, 平澤 玲子, 伊部 陽子, 谷内 洋子, 平安座 依子, 斉藤 あき, 菅原 歩美, 戸塚 久美子, 阿隅 美保子, 鈴木 恵美子, 近藤 和雄, 曽根 博仁

    日本成人病(生活習慣病)学会会誌   36   61 - 61   2010年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 2型糖尿病患者における就寝・起床時刻と血糖コントロールの関連についての探索的検討

    齋藤あき, 西垣結佳子, 川井紘一, 大石まり子, 杉本英克, 栗林伸一, 和田崇子, 齋藤和美, 児玉暁, 曽根博仁

    日本成人病(生活習慣病)学会会誌   36   100 - 100   2010年1月

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  • アルコール性肝硬変に伴った肝細胞癌の1例

    児玉暁

    旭川市立病院医誌   41 ( 1 )   32 - 34   2009年12月

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    記述言語:日本語   出版者・発行元:市立旭川病院  

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  • 慢性疾患における身体活動・運動 運動と脂質異常症

    児玉暁, 曽根博仁

    実験治療   ( 696 )   145 - 149   2009年12月

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    記述言語:日本語   出版者・発行元:武田薬品工業(株)医薬学術部  

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  • 生活習慣病の臨床エビデンス 第15回 全死亡および冠動脈疾患リスクにおける心肺機能の意義

    児玉暁, 曽根博仁

    肥満と糖尿病   8 ( 5 )   754 - 757   2009年9月

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  • 生活習慣病の臨床エビデンス 全死亡および冠動脈疾患リスクにおける心肺機能の意義

    児玉 暁, 曽根 博仁

    Q&Aでわかる肥満と糖尿病   8 ( 5 )   754 - 757   2009年9月

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    記述言語:日本語   出版者・発行元:(株)丹水社  

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  • 頸動脈内膜中膜複合体厚(IMT)と大脳白質変化の関連性 横断的検討

    山口 龍生, 阿隅 美保子, 鶉橋 弘子, 古川 豊, 齋藤 和美, 児玉 暁, 宮澤 英充, 松井 博滋, 福田 寛, 曽根 博仁

    人間ドック   24 ( 2 )   347 - 347   2009年8月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • Self-Reported Eating Fast Is a Potent Predictor of Development of Impaired Glucose Tolerance in Japanese Men and women: Tsukuba Medical Center Study

    Kumiko Totsuka, Kimi Maeno, Kazumi Saito, Satoru Kodama, Ayumi Sugawara, Mihoko Asumi, Yoko Yachi, Miho Make, Hitoshi Shimano, Nobuhiro Yamada, Yukio Ono, Takashi Naito, Hirohito Sone

    DIABETES   58   A432 - A432   2009年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    Web of Science

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  • Is Serum Uric Acid Level a Predictor of Development of Type 2 Diabetes Mellitus? A Meta-Analysis

    Satoru Kodama, Kazumi Saito, Mihoko Asumi, Aki Saito, Yoko Yachi, Miho Maki, Yukako Nishigaki, Nobuhiro Yamada, Hirohito Sone

    DIABETES   58   A264 - A265   2009年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

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  • 生活習慣病の臨床エビデンス 第13回 2型糖尿病における低脂肪食

    児玉暁, 曽根博仁

    肥満と糖尿病   8 ( 3 )   451 - 453   2009年5月

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  • 若年期のう歯数とその後の死亡率に関する長期縦断研究

    佐藤 睦美, 菅原 歩美, 福士 亜矢子, 戸塚 久美子, 阿隅 美保子, 牧 美保, 谷内 洋子, 齋藤 和美, 児玉 暁, 曽根 博仁

    成人病と生活習慣病   39 ( 5 )   566 - 567   2009年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 耐糖能異常および糖尿病発症における食習慣の意義に関する検討

    戸塚 久美子, 児玉 暁, 阿隅 美保子, 牧 美保, 穴迫 唯衣, 伊部 陽子, 曽根 博仁, 前野 貴美, 小野 幸雄, 内藤 隆志

    成人病と生活習慣病   39 ( 5 )   579 - 580   2009年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 健常者における運動耐容能と心血管疾患発症リスクとの数量的関係についてのメタ解析

    児玉 暁, 牧 美保, 齋藤 和美, 佐藤 睦美, 穴迫 唯衣, 阿隅 美保子, 谷内 洋子, 曽根 保子, 曽根 博仁, 山田 信博

    成人病と生活習慣病   39 ( 5 )   571 - 571   2009年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 若年期の体力(全身持久力)が生活習慣病罹患状況および全死亡率に与える影響の検討

    佐藤 睦美, 児玉 暁, 阿隅 美保子, 西垣 結佳子, 叔 森, 不老 美也子, 曽根 保子, 鈴木 恵美子, 曽根 博仁

    成人病と生活習慣病   39 ( 5 )   577 - 578   2009年5月

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  • 生活習慣病の臨床エビデンス 2型糖尿病における低脂肪食

    児玉 暁, 曽根 博仁

    Q&Aでわかる肥満と糖尿病   8 ( 3 )   451 - 453   2009年5月

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    記述言語:日本語   出版者・発行元:(株)丹水社  

    2型糖尿病患者において糖・脂質比の異なる食事の代謝への影響を比較した無作為化対照試験の文献を検索し、19個の研究を抽出した。糖・脂質比が高いほうに分類された食事群における糖質の総エネルギーに占める割合は51〜73%(中央値60%)、糖・脂質比は1.7〜7.3(中央値2.4)であった。各研究の結果をまとめると、糖代謝についてはHbA1cや空腹時血糖への効果には群間差がみられなかったが、空腹時インスリンや血糖、インスリンの食後2時間値はいずれも、糖・脂質比の高い食事が低い食事と比較して有意に大きな上昇を示した。また、脂質代謝においては、総コレステロールやLDLコレステロールは群間差がなく、トリグリセリド(TG)上昇、HDLコレステロール低下が糖・脂質比の高い食事でみられた。この傾向は、比較的若年、非肥満者に対し糖・脂質比が特に高い食事介入を行った研究で顕著であった。減量を含めた介入を行った場合には、TG上昇が抑制されていた。

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  • 日本人糖尿病患者における心臓自律神経障害の発症率

    齋藤 和美, 児玉 暁, 菅原 歩美, 戸塚 久美子, 齋藤 あき, 西垣 結佳子, 曽根 博仁, 川井 紘一, 本橋 しのぶ, 小林 和人, 山田 信博

    成人病と生活習慣病   39 ( 5 )   582 - 582   2009年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • アスコルビン酸濃度の違いによる遺伝子発現変化の検討

    曽根保子, 丑田晴菜, 児玉暁, 齋藤和美, 山王丸靖子, 三宅紀子, 曽根博仁, 倉田忠男, 鈴木恵美子

    ビタミン   83 ( 4 )   198 - 198   2009年4月

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    記述言語:日本語   出版者・発行元:(公社)日本ビタミン学会  

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  • 健常者の脂肪負荷後血中トリグリセリド値に影響を与える因子の検討

    福士亜矢子, 児玉暁, 齋藤和美, 谷内洋子, 菅原歩美, 戸塚久美子, 叔びょう, 齋藤和典, 近藤和雄, 曽根博仁

    日本未病システム学会雑誌   14 ( 2 )   260 - 263   2009年3月

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    記述言語:日本語   出版者・発行元:(一社)日本未病システム学会  

    食後高脂血症は、冠動脈疾患をはじめとする動脈硬化疾患との関連が指摘されている。食後高脂血症は、経口脂肪負荷試験(OFTT)におけるトリグリセリド(TG)反応により診断されることが多いが、検査が繁雑で長時間を要するため被験者の負担が大きい。その上、標準化された方法や正常値なども確立していない。本研究では基礎的検討として健常者を対象とし、(1)脂肪負荷後TG反応に影響を及ぼす因子は何か、(2)OFTTを簡略化し、あるいはOFTTを行わずに、脂肪負荷後TG反応を予測することは可能か、の2点を目的とした。健常人男女40人を対象としてOFTTを実施し、インスリン抵抗性関連指標(HOMA-IR、HOMA-β、QUICKI)をはじめとする他の各種空腹時採血指標や対象者の特徴とともに重回帰分析を用いて検討した。その結果、TGの曲線下面積(TG AUC)は空腹時のTG値、apoA-II、HOMA-β、HDL-Cが、それぞれ独立した有意な予測因子であった。TGのピーク値(TG peak)には空腹時のTG値、apoA-II、インスリンが関与していた。以上の結果より、今回のOFTT時TG反応には、空腹時TGとともにインスリン抵抗性や血中アポ蛋白A-IIなどが独立して関連していることが示された。これらの結果より、対象者の特徴と空腹時単回採血結果より、OFTT時TG反応はOFTTを実施しなくてもかなり予測し得ることが示唆された。今後は有疾患者も含め、多数例で検討する必要があるものの、本研究の結果は食後高脂血症の病態の解明、また診断法確立の一助となると考えられる。(著者抄録)

    DOI: 10.11288/mibyou1998.14.260

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  • 頸動脈内中膜複合体厚(IMT)に関連する因子の横断的検討

    阿隅美保子, 佐伯晃, 古川豊, 秋山朋子, 大泉卓美, 鶉橋弘子, 齋藤和美, 児玉暁, 宮澤英充, 松井博滋, 山口龍生, 福田寛, 曽根博仁

    日本未病システム学会雑誌   14 ( 2 )   234 - 236   2009年3月

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    記述言語:日本語   出版者・発行元:(一社)日本未病システム学会  

    2005年5月〜2006年3月に動脈硬化度健診を受診した188名(男87名、女101名、平均59±1歳)を対象に、頸動脈内中膜複合体厚(IMT)を測定し、対象者を最大値(IMT-max)により低値群(1.1mm未満)50名、高値群(1.1mm以上)138名に分け、IMTと関連する因子について検討した。女性は全員が非喫煙者で、喫煙者は男性のみであるため男女別の解析を行った。女性ではLDLコレステロールが動脈硬化の指標として有用であることがわかった。一方、男性では下肢血管の動脈硬化と脳動脈硬化が並行して観察される傾向があり、喫煙が脳動脈硬化の進行に重要であることが示された。従来の動脈硬化疾患危険因子が、潜在的な脳動脈硬化とどの程度関連しているかが明らかになった。

    DOI: 10.11288/mibyou1998.14.234

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  • 運動耐容能が冠動脈疾患発症に及ぼす影響に関する定量的メタ解析

    児玉暁, 齋藤和美, 牧美保, 阿隅美保子, 谷内洋子, 小林和人, 高橋昭光, 島野仁, 山田信博, 曽根博仁

    日本内科学会雑誌   98 ( Suppl. )   130 - 130   2009年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • 耐糖能異常および糖尿病発症における食習慣の意義に関する検討

    戸塚久美子, 前野貴美, 児玉暁, 阿隅美保子, 牧美保子, 穴迫結衣, 伊部陽子, 小野幸雄, 内藤隆志, 曽根博仁

    日本成人病(生活習慣病)学会会誌   35   65 - 65   2009年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 若年期の体力(全身持久力)が生活習慣病罹患状況および全死亡率に与える影響の検討

    佐藤睦美, 児玉暁, 阿隅美保子, 西垣結佳子, 叔森, 不老美也子, 曽根保子, 鈴木恵美子, 曽根博仁

    日本成人病(生活習慣病)学会会誌   35   63 - 63   2009年1月

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    記述言語:日本語   出版者・発行元:日本成人病(生活習慣病)学会  

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  • 日本人糖尿病患者における心臓自律神経障害の発症率

    齋藤和美, 川井紘一, 児玉暁, 本橋しのぶ, 菅原歩美, 戸塚久美子, 齋藤あき, 西垣結佳子, 小林和人, 山田信博, 曽根博仁

    日本成人病(生活習慣病)学会会誌   35   67 - 67   2009年1月

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  • 若年期の損失歯数とその後の死亡率に関する長期縦断研究

    佐藤睦美, 菅原歩美, 福士亜矢子, 戸塚久美子, 阿隅美保子, 牧美保, 谷内洋子, 斎藤和美, 児玉暁, 曽根博仁

    日本成人病(生活習慣病)学会会誌   35   51 - 51   2009年1月

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  • 健常者における運動耐容能と心血管疾患発症リスクとの数量的関係についてのメタ解析

    児玉暁, 牧美保, 斉藤和美, 佐藤睦美, 戸塚久美子, 穴迫唯衣, 阿隅美保子, 谷内洋子, 曽根保子, 曽根博仁

    日本成人病(生活習慣病)学会会誌   35   55 - 55   2009年1月

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  • 2-I-30 アスコルビン酸濃度の違いによる遺伝子発現変化の検討(一般研究発表,日本ビタミン学会第61回大会研究発表要旨)

    曽根 保子, 丑田 晴菜, 児玉 暁, 齋藤 和美, 山王丸 靖子, 三宅 紀子, 曽根 博仁, 倉田 忠男, 鈴木 恵美子

    ビタミン   83 ( 4 )   198 - 198   2009年

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    記述言語:日本語   出版者・発行元:公益社団法人 日本ビタミン学会  

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  • INFLUENCE OF VITAMIN C LEVEL ON THE GENE EXPRESSION IN PRIMARY HEPATOCYTE OF ODS RAT

    Yasuko Sone, Kazumi Saitou, Fumiko Onitake, Yasuko Sannoumaru, Etsuko Ueta, Noriko Miyake, Hirohito Sone, Eiji Namba, Masahiro Inagaki, Yuzuru Otsuka, Kazuo Kondo, Tadao Kurata, Emiko Suzuki, Miao Shu, Satoru Kodama

    ANNALS OF NUTRITION AND METABOLISM   55   445 - 445   2009年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:KARGER  

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  • 一般健常者における運動耐用能が心血管疾患発症リスクに及ぼす影響のメタアナリシス

    児玉暁, 牧美保, 斉藤和美, 佐藤睦美, 穴迫唯衣, 阿隅美保子, 谷内洋子, 曽根保子, 山田信博, 曽根博仁

    日本未病システム学会学術総会抄録集   15th   91   2008年9月

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  • 思春期女性におけるボディーイメージの現状とその関連因子の検討

    菅原歩美, 佐藤睦美, 戸塚久美子, 児玉暁, 松島悦子, 藤原葉子, 栗原恵美子, 山梨八重子, 佐藤道幸, 石井朋子, 田中京子, 菊池美千世, 山本茂, 近藤和雄, 曽根博仁

    日本未病システム学会学術総会抄録集   15th   86   2008年9月

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  • 健常者の脂肪負荷後血中トリグリセリド値に影響を与える因子の検討

    福士亜矢子, 児玉暁, 齋藤和美, 谷内洋子, 菅原歩美, 戸塚久美子, 叔びょう, 齋藤和典, 近藤和雄, 曽根博仁

    日本未病システム学会学術総会抄録集   15th   115   2008年9月

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  • 頸動脈内中膜複合体厚(IMT)に関連する因子の横断的検討

    阿隅美保子, 佐伯晃, 古川豊, 秋山朋子, 大泉卓美, 鶉橋弘子, 齋藤和美, 児玉暁, 宮澤英充, 松井博滋, 山口龍生, 福田寛, 曽根博仁

    日本未病システム学会学術総会抄録集   15th   95   2008年9月

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  • 耐糖能異常及び糖尿病発症の予測因子として脂肪肝は肝機能検査異常よりも優れた指標である

    戸塚久美子, 前野貴美, 児玉暁, 阿隅美保子, 佐藤睦美, 西垣結佳子, 齊藤あき, 平沼ゆり, 小野幸雄, 内藤隆志, 曽根博仁

    日本未病システム学会学術総会抄録集   15th   142   2008年9月

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  • 青少年期における有酸素運動能力(総合体力)とその後の寿命および生活習慣病罹患に関する長期縦断研究

    佐藤睦美, 児玉暁, 穴迫唯衣, 牧美保, 戸塚久美子, 斎藤あき, 増田かやの, 石井朋子, 室岡和彦, 鈴木恵美子, 近藤和雄, 曽根博仁

    日本未病システム学会学術総会抄録集   15th   140   2008年9月

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  • 健常人男女における脂肪負荷後血中トリグリセリド変化に関与する因子の探索

    福士亜矢子, 佐藤睦美, 菅原歩美, 谷内洋子, 伊部陽子, 児玉暁, 齊藤和美, 近藤和雄, 曽根博仁

    栄養学雑誌   66 ( 5 Supplement )   143   2008年9月

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  • 青少年期の全身持久力および総合運動能力がその後の健康状態に及ぼす影響

    佐藤睦美, 菅原歩美, 戸塚久美子, 福士亜矢子, 谷内洋子, 伊部陽子, 斎藤和美, 児玉暁, 曽根博仁

    栄養学雑誌   66 ( 5 Supplement )   206   2008年9月

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  • 青年期および若年日本人女性のやせの現状と関連要因の検討

    菅原歩美, 佐藤睦美, 福士亜矢子, 戸塚久美子, 伊部陽子, 谷内洋子, 齋藤和美, 児玉暁, 曽根博仁

    栄養学雑誌   66 ( 5 Supplement )   162   2008年9月

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  • 日本人2型糖尿病患者の微量アルブミン尿の寛解に影響する因子の検討

    齋藤 和美, 児玉 暁, 姫野 彰子, 近藤 和雄, 曽根 博仁, 川井 紘一, 田中 司朗, 大橋 靖雄, 山田 信博

    成人病と生活習慣病   38 ( 5 )   562 - 562   2008年5月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 2型糖尿病における食事の糖・脂質(C/F)比の変化が血糖コントロールに及ぼす影響のメタアナリシス

    児玉 暁, 斉藤 和美, 姫野 彰子, 鈴木 恵美子, 曽根 博仁, 田中 司朗, 大橋 靖雄, 山田 信博

    成人病と生活習慣病   38 ( 5 )   564 - 565   2008年5月

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  • 2型糖尿病患者の早期腎症の改善因子に関する前向き研究

    齋藤和美, 川井紘一, 児玉暁, 本橋しのぶ, 坂巻顕太郎, 田中司朗, 大橋靖雄, 高橋昭光, 島野仁, 山田信博, 曽根博仁

    糖尿病   51 ( Supplement 1 )   S.133 - 133   2008年4月

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  • ODSラットにおけるアスコルビン酸の栄養状態の違いによる輸送担体の発現変動

    曽根保子, 谷口サチ, 児玉暁, 齋藤和美, 曽根博仁, 山王丸靖子, 三宅紀子, 倉田忠男, 鈴木恵美子

    ビタミン   82 ( 4 )   308 - 308   2008年4月

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  • 糖尿病早期腎症の寛解に関する時間依存性Coxの比例ハザードモデルによる検討

    齋藤和美, 川井紘一, 児玉暁, 本橋しのぶ, 坂巻顕太郎, 田中司朗, 大橋靖雄, 高橋昭光, 島野仁, 山田信博, 曽根博仁

    日本内分泌学会雑誌   83 ( 4 )   1014 - 1014   2008年3月

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  • 2型糖尿病食事療法における糖・脂質比の変化と血糖コントロール改善効果のメタ解析

    児玉暁, 齋藤和美, 田中司朗, 鈴木恵美子, 大橋靖雄, 島野仁, 高橋昭光, 山田信博, 曽根博仁

    日本内科学会雑誌   97 ( Suppl. )   234 - 234   2008年2月

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  • 2型糖尿病食事療法の糖・脂質比の変化が血糖コントロールに及ぼす影響のメタアナリシス

    児玉暁, 田中司朗, 斉藤和美, 牧美保, 谷内洋子, 阿隅美保子, 伊部陽子, 大橋靖雄, 曽根博仁

    Journal of Epidemiology   18 ( 1 Supplement )   183   2008年1月

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  • 日本人2型糖尿病患者の微量アルブミン尿の寛解に影響する因子の検討

    齋藤和美, 川井紘一, 児玉暁, 田中司朗, 姫野彰子, 近藤和雄, 大橋靖雄, 山田信博, 曽根博仁

    日本成人病(生活習慣病)学会会誌   34   49 - 49   2008年1月

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  • 糖尿病食事療法における糖・脂質比の変化が血糖コントロールに及ぼす影響のメタ解析

    児玉暁, 斉藤和美, 田中司朗, 姫野彰子, 鈴木恵美子, 大橋靖雄, 山田信博, 曽根博仁

    日本成人病(生活習慣病)学会会誌   34   51   2008年1月

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  • 2-IV-31 ODSラットにおけるアスコルビン酸の栄養状態の違いによる輸送担体の発現変動(一般研究発表,新世紀ビタミン学の展望と先進的展開を目指して,日本ビタミン学会第60回大会発表要旨)

    曽根 保子, 谷口 サチ, 児玉 暁, 齋藤 和美, 曽根 博仁, 山王丸 靖子, 三宅 紀子, 倉田 忠男, 鈴木 恵美子

    ビタミン   82 ( 4 )   308 - 308   2008年

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    記述言語:日本語   出版者・発行元:公益社団法人 日本ビタミン学会  

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  • 健常者の脂肪負荷後血中トリグリセリド値に影響を与える因子の検討

    福士 亜矢子, 曽根 博仁, 児玉 暁, 齋藤 和美, 谷内 洋子, 菅原 歩美, 戸塚 久美子, 叔 〓, 齋藤 和典, 近藤 和雄

    日本未病システム学会雑誌   14 ( 2 )   260 - 263   2008年

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    記述言語:日本語   出版者・発行元:日本未病システム学会  

    食後高脂血症は, 冠動脈疾患をはじめとする動脈硬化疾患との関連が指摘されている。食後高脂血症は, 経口脂肪負荷試験 (OFTT) におけるトリグリセリド (TG) 反応により診断されることが多いが, 検査が繁雑で長時間を要するため被験者の負担が大きい。その上, 標準化された方法や正常値なども確立していない。本研究では基礎的検討として健常者を対象とし, (1) 脂肪負荷後TG反応に影響を及ぼす因子は何か, (2) OFTTを簡略化し, あるいはOFTTを行わずに, 脂肪負荷後TG反応を予測することは可能か, の2点を目的とした。健常人男女40人を対象としてOFTTを実施し, インスリン抵抗性関連指標 (HOMA-IR, HOMA-β, QUICKI) をはじめとする他の各種空腹時採血指標や対象者の特徴とともに重回帰分析を用いて検討した。その結果, TGの曲線下面積 (TG AUC) は空腹時のTG値, apoA-II, HOMA-β, HDL-Cが, それぞれ独立した有意な予測因子であった。TGのピーク値 (TG peak) には空腹時のTG値, apoA-II, インスリンが関与していた。以上の結果より, 今回のOFTT時TG反応には, 空腹時TGとともにインスリン抵抗性や血中アポ蛋白A-IIなどが独立して関連していることが示された。これらの結果より, 対象者の特徴と空腹時単回採血結果より, OFTT時TG反応はOFTTを実施しなくてもかなり予測し得ることが示唆された。今後は有疾患者も含め, 多数例で検討する必要があるものの, 本研究の結果は食後高脂血症の病態の解明, また診断法確立の一助となると考えられる。

    DOI: 10.11288/mibyou1998.14.260

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  • 健常者の脂肪負荷後血中トリグリセリド値に影響を与える因子の検討 (第15回日本未病システム学会学術総会論文集)

    福士 亜矢子, 児玉 暁, 齋藤 和美

    日本未病システム学会雑誌   14 ( 2 )   260 - 263   2008年

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    DOI: 10.11288/mibyou1998.14.260

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