Updated on 2025/06/25

写真a

 
TERAI Shuji
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Professor
Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Cellular Function Professor
Title
Professor
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The Best Research Achievement in Research Career

    • 【Papers】 Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy  2006.10

    • 【Papers】 Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis.  2021.3

    • 【Awards】 The Japanese Society for Regenerative Medicine Award  2022.3

Degree

  • 医学博士 ( 1997.2   山口大学 )

Research Interests

  • 発癌

  • 脂肪化

  • 線維化

  • 幹細胞

  • 血管新生

  • 再生

  • Extracellular Vesicles (exosome)

Research Areas

  • Life Science / Gastroenterology  / 消化器病学、肝臓病学、内科学、再生医学、エクソソーム

Research History

  • Niigata University   University Medical and Dental Hospital Department of Endoscopy   Manager(Dean)

    2016.4

  • Niigata University   University Medical and Dental Hospital   Manager(Dean)

    2016.4

  • Niigata University   University Medical and Dental Hospital

    2015.1

  • Niigata University   Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Cellular Function   Professor

    2015.1

Studying abroad experiences

  • Laboratory of Experimental Carcinogenesis (Chief : Dr. Snorri S. Thorgeirsson), NCI, NIH Bethesda   Guest Researcher

    1998.7 - 2000.7

 

Papers

  • Guidance on the clinical application of extracellular vesicles. International journal

    Shuji Terai, Motohiro Asonuma, Ayuko Hoshino, Masahiro Kino-Oka, Takahiro Ochiya, Kiyoshi Okada, Yoji Sato, Yuki Takahashi, Morikuni Tobita, Atsunori Tsuchiya

    Regenerative therapy   29   43 - 50   2025.6

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    Therapies using extracellular vesicles (EVs), exosomes, or cell culture supernatants containing EVs or exosomes (referred to as "EV therapies" in this Guidance) have garnered an increasing amount of interest. However, pharmaceutical products containing EVs as their main active ingredient are yet to receive regulatory approval. The "Basic points to consider regarding the preparation of extracellular vesicles and their clinical applications in Japan," was announced by the Japanese Society for Regenerative Medicine (JSRM) on March 10, 2021, with a specific focus on exosomes among EVs to promote high safety standards in this evolving field and facilitate the application of EV clinically. The Scientific Committee of the Pharmaceuticals and Medical Devices Agency and the Japanese Society for Extracellular Vesicles have issued reports and statements regarding treatment, resulting in a growing momentum toward treatment in Japan. This article summarized the basic items that should be recognized comprehensively for clinical practice in three categories: (1) risk profiling, (2) preparation (manufacturing) process and quality, and (3) verification of EVs checking items and effectiveness. This guideline will be revised in the future with technological innovations and new findings; nevertheless, it will serve as a guide for the development of treatments.

    DOI: 10.1016/j.reth.2025.02.008

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  • Safety of edoxaban for delayed bleeding in gastrointestinal endoscopic procedures with a high risk of bleeding. International journal

    Ken-Ichi Mizuno, Junji Yokoyama, Osamu Shibata, Yuichi Kojima, Yuzo Kawata, Kazuya Takahashi, Kentaro Tominaga, Igarashi Satoshi, Hayashi Kazunao, Shuji Terai

    DEN open   5 ( 1 )   e70018   2025.4

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    OBJECTIVES: There are limited reports on the safety of gastrointestinal endoscopic procedures in individuals taking edoxaban, one of the direct oral anticoagulants. We clarified the incidence of delayed bleeding in patients who were on edoxaban in the perioperative period of gastrointestinal endoscopic procedures with a high risk of bleeding. METHODS: This was an investigator-initiated, single-center, open-label, prospective, single-arm study. Patients on warfarin or edoxaban undergoing endoscopy with a high risk of bleeding were enrolled from June 2018 to September 2021. Warfarin was replaced with edoxaban in patients on warfarin. Patients taking other direct oral anticoagulants, and antiplatelet drugs, were excluded. The primary endpoint was severe delayed bleeding (Common Terminology Criteria for Adverse Events [CTCAE] grades III-V) and the secondary endpoints included thromboembolism, all adverse events, any delayed bleeding (CTCAE grades I or II), and hospital stay durations. RESULTS: Twenty-one patients on edoxaban underwent high-risk endoscopy. Three cases (14%) experienced CTCAE grade III delayed bleeding, requiring endoscopic hemostasis. No CTCAE grade I-II delayed bleeding or thromboembolic events occurred. Cholangitis and aspiration pneumonia (conservatively treated) occurred during the hospital stay. The median length of hospital stay was 8 days (range 3-24 days). Patients with delayed bleeding had higher systolic blood pressure at admission and longer hospital stays. CONCLUSIONS: The delayed bleeding incidence in high-risk endoscopic procedures for patients on edoxaban was acceptable. Higher blood pressure may be associated with increased risk, but further research is needed.

    DOI: 10.1002/deo2.70018

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  • Coexistence of Relapsing Polychondritis, Crohn's Disease, and Pyoderma Gangrenosum Treated Successfully with Adalimumab: A Case Report and Literature Review.

    Shun Yamazaki, Kentaro Tominaga, Kotaro Watanabe, Makoto Watanabe, Shuhei Kondo, Norihiro Sakai, Tomoaki Yoshida, Yuichi Kojima, Yusuke Watanabe, Yuzo Kawata, Naruhiro Kimura, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Hiroteru Kamimura, Kazunao Hayashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   2025.3

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    Relapsing polychondritis (RP) is a rare, progressive, immune-mediated systemic inflammatory disease of unknown etiology characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with autoimmune disease. However, co-occurrence of RP and Crohn's disease (CD) has rarely been reported. We herein report a case of coexisting RP, CD, and pyoderma gangrenosum that was successfully treated with adalimumab in combination with methotrexate. We believe that this case and literature review will facilitate the accurate and prompt diagnosis and treatment of RP combined with CD and various other complications.

    DOI: 10.2169/internalmedicine.5024-24

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  • Current management and future perspectives of covert hepatic encephalopathy in Japan: a nationwide survey.

    Takao Miwa, Mio Tsuruoka, Hajime Ueda, Tamami Abe, Hiroki Inada, Yoshimi Yukawa-Muto, Masatsugu Ohara, Taeang Arai, Yasuyuki Tamai, Hiroshi Isoda, Tomoko Tadokoro, Tatsunori Hanai, Takanori Ito, Nobuharu Tamaki, Akira Sakamaki, Yoshihiko Aoki, Fujimasa Tada, Sachiyo Yoshio, Hirokazu Takahashi, Asahiro Morishita, Tsuyoshi Ishikawa, Jun Inoue, Goki Suda, Chikara Ogawa, Masanori Atsukawa, Atsushi Hiraoka, Hidekatsu Kuroda, Tadashi Namisaki, Takashi Honda, Takumi Kawaguchi, Yasuhito Tanaka, Shuji Terai, Tadashi Ikegami, Hitoshi Yoshiji, Motoh Iwasa, Masahito Shimizu

    Journal of gastroenterology   2025.3

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    BACKGROUND: Covert hepatic encephalopathy (CHE) leads to devastating outcomes in patients with cirrhosis. This study aims to elucidate the current management and future perspectives of CHE in Japan. METHODS: A questionnaire-based cross-sectional study was conducted among physicians involved in managing cirrhosis in Japan. The primary aim was to elucidate the real-world management of CHE, including testing and treatment. Factors influencing the implementation of CHE testing were analyzed using a logistic regression model. Limitations and future perspectives for improving the management of CHE were also evaluated. RESULTS: Of 511 physicians surveyed, 93.9% recognized CHE as a significant problem, and 86.9% agreed that it should be tested. Overall, 62.8% of physicians tested for CHE, whereas 37.2% did not. Multivariable analysis identified institutional factors and certifying board as significant determinants of CHE test implementation. The Stroop (68.2%) and neuropsychiatric tests (57.5%) were the most commonly used methods of identifying CHE. Among those who tested for CHE, 87.7% treated CHE; the most common treatments were lactulose (81.5%), rifaximin (76.3%), and branched-chain amino acids (70.4%). Among non-testers, the primary barrier was the time requirement for testing. Proposals to encourage CHE testing included the development of simple tests and integration of multidisciplinary teams. CONCLUSIONS: Most physicians involved in cirrhosis care in Japan recognize CHE as a significant problem that warrants testing. However, testing for CHE remains limited by institutional factors and physician specialties. Time requirements for CHE testing are the primary barrier, and simple tests and multidisciplinary teams are recommended to enhance CHE management.

    DOI: 10.1007/s00535-025-02232-0

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  • Targeted animal models for preclinical assessment of cellular and gene therapies in pancreatic and liver diseases: regulatory and practical insights. International journal

    Hongjun Wang, Rachele Ciccocioppo, Shuji Terai, Sara Shoeibi, Gianluca Carnevale, Giulia De Marchi, Atsunori Tsuchiya, Soichi Ishii, Takafumi Tonouchi, Kaito Furuyama, Yuan Yang, Masaki Mito, Hiroyuki Abe, Rosanna Di Tinco, Vincenzo Cardinale

    Cytotherapy   27 ( 3 )   259 - 278   2025.3

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    Cellular and gene therapy (CGT) products have emerged as a popular approach in regenerative medicine, showing promise in treating various pancreatic and liver diseases in numerous clinical trials. Before these therapies can be tested in human clinical trials, it is essential to evaluate their safety and efficacy in relevant animal models. Such preclinical testing is often required to obtain regulatory approval for investigational new drugs. However, there is a lack of detailed guidance on selecting appropriate animal models for CGT therapies targeting specific pancreatic and liver conditions, such as pancreatitis and chronic liver diseases. In this review, the gastrointestinal committee for the International Society for Cell and Gene Therapy provides a summary of current recommendations for animal species and disease model selection, as outlined by the US Food and Drug Administration, with references to EU EMA and Japan PMDA. We discuss a range of small and large animal models, as well as humanized models, that are suitable for preclinical testing of CGT products aimed at treating pancreatic and liver diseases. For each model, we cover the associated pathophysiology, commonly used metrics for assessing disease status, the pros and limitations of the models, and the relevance of these models to human conditions. We also summarize the use and application of humanized mouse and other animal models in evaluating the safety and efficacy of CGT products. This review aims to provide comprehensive guidance for selecting appropriate animal species and models to help bridge the gap between the preclinical research and clinical trials using CGT therapies for specific pancreatic and liver diseases.

    DOI: 10.1016/j.jcyt.2024.11.008

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  • Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells. International journal

    Natsuki Ishikawa, Yusuke Watanabe, Yuichirou Maeda, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    Regenerative therapy   28   509 - 516   2025.3

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    INTRODUCTION: Cirrhosis is a disease with poor prognosis that requires the development of a novel therapeutic approach alternative to liver transplantation. In this study, we focused on the placenta and aimed to clarify the effects of human placental extract (HPE) on cirrhosis. METHODS: A mouse model of carbon tetrachloride-induced cirrhosis was used to evaluate the effect of HPE administration subcutaneously and compared with the control group (n = 8 for each group). In vitro and in vivo, real time-PCR and immunostaining were performed for HPE mechanistic analysis. Spatial transcriptomics was also performed for detailed analysis of the effect of HPE on cirrhosis. RESULTS: HPE administration improved serum ALT levels compared to control mice. Furthermore, there was a decrease in the number of senescent cells in the liver and the mRNA levels of secrete senescence-associated secretory phenotype factors and Cdkn2a (p16). In vitro, HPE induced macrophage polarization to the anti-inflammatory M2 phenotype. Spatial transcriptomics was also performed to analyze the underlying anti-inflammatory mechanism. The results showed that HPE strongly polarized macrophages to the M2 phenotype, especially in macrophage-rich regions in the liver. Gene expression pathway analysis using spatial transcriptomics also revealed the possibility of improving senescent cell-derived inflammation via mitochondrial function. CONCLUSIONS: HPE improves serum ALT levels via anti-inflammatory mechanisms in macrophages and senescent cells. HPE serves as a novel agent for cirrhosis treatment.

    DOI: 10.1016/j.reth.2025.01.017

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  • Extremely Rare Isolated Small-Intestinal Polyp Diagnosed by Double-Balloon Endoscopy in an Asymptomatic Adult Patient. International journal

    Kentaro Tominaga, Annenkov Alexey, Yuto Tanaka, Osamu Shibata, Yuichi Kojima, Yuzo Kawata, Nao Nakajima, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Shuji Terai

    Clinical case reports   13 ( 3 )   e70255   2025.3

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    We present the first reported case of an isolated small-bowel intestinal juvenile polyp in an adult. This case is particularly noteworthy as it was asymptomatic, detected via computed tomography, localized by capsule endoscopy, and successfully resected via double-balloon endoscopy before the development of acute symptoms.

    DOI: 10.1002/ccr3.70255

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  • Small Intestinal Bacterial Overgrowth Is a Predictor of Overt Hepatic Encephalopathy in Patients with Liver Cirrhosis. International journal

    Akira Sakamaki, Kunihiko Yokoyama, Hanako Yamazaki, Takuya Wakabayashi, Yuichi Kojima, Kentaro Tominaga, Atsunori Tsuchiya, Kenya Kamimura, Junji Yokoyama, Shuji Terai

    Journal of clinical medicine   14 ( 5 )   2025.2

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    Objective: Liver cirrhosis (LC) progression induces intestinal microbiota abnormalities, such as small intestinal bacterial overgrowth (SIBO), and these changes lead to the inflow of gut pathogens and their degradation products into the vessels, causing cirrhotic complications such as hepatic encephalopathy (HE). Methods: To clarify the relationship between the development of overt HE and SIBO, we conducted a three-year observation after assessment of SIBO in patients with LC. Results: In the analysis of 107 patients, with a mean follow-up duration of 29.4 months, 31 were diagnosed with SIBO and 30 with covert HE. In the Cox multivariate regression analysis for prognosis, the Child-Pugh score, blood urea nitrogen level, and the Union for International Cancer Control (UICC) stage of hepatocellular carcinoma were derived using the following five factors: white blood cell count, blood urea nitrogen level, Child-Pugh score, UICC stage, and serum aspartate aminotransferase and alkaline phosphatase levels (p = 0.002, hazard ratio [HR] 3.733, 95% confidence interval [CI] 1.592-8.754, p = 0.001, HR 1.076, 95% CI 1.030-1.123, and p < 0.001, HR 2.767, 95% CI 1.780-4.302, respectively). Furthermore, in the Cox multivariate regression analysis for overt HE development, covert HE and methane-producing SIBO were derived using the following four factors: methane-producing SIBO, UICC stage, covert HE, and serum ammonia levels (p = 0.038, HR 5.008, 95% CI 1.096-22.892 and p = 0.006, HR 8.597, 95% CI 1.881-39.291, respectively). Conclusions: M-SIBO positivity was a significant predictor of overt HE.

    DOI: 10.3390/jcm14051491

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  • Pruritus in Chronic Cholestatic Liver Diseases, Especially in Primary Biliary Cholangitis: A Narrative Review. International journal

    Tatsuo Kanda, Reina Sasaki-Tanaka, Naruhiro Kimura, Hiroyuki Abe, Tomoaki Yoshida, Kazunao Hayashi, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, Kenya Kamimura, Shuji Terai

    International journal of molecular sciences   26 ( 5 )   2025.2

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    Patients with chronic cholestatic liver diseases often experience itch and struggle with this symptom. We discuss the mechanism of itch in patients with chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and others, and their therapies, including ileal bile acid transporter (IBAT) inhibitors. In patients with PBC, there are high serum/plasma concentrations of multiple factors, including bile salts, bilirubin, endogenous opioids, lysophosphatidic acid (LPA), autotaxin, and histamine. Bile salts, bilirubin, LPA, and autotaxin affect itch mediators in the skin and sensory nerves, while the endogenous opioid balance affects mediators in the spinal cord. Itch is sensitized by both the peripheral and central nervous systems. Both mechanisms are involved in itch in patients with chronic cholestatic liver disease. Although IBAT inhibitors have been approved for use in pediatric cholestatic conditions, such as progressive familial intrahepatic cholestasis and Alagille syndrome, IBAT inhibition seems to be a promising treatment for chronic refractory itch in patients with PBC. A traditional non-systematic review results in this narrative review. Multidisciplinary cooperation, involving hepatologists, dermatologists, and pharmacists, could provide better treatment for PBC patients suffering from refractory itch. In conclusion, we summarized the existing knowledge on itch caused by chronic cholestatic liver diseases, especially in PBC with a focus on the mechanisms and therapies. This narrative review provides the mechanisms and therapeutic options for itch in patients with chronic cholestatic liver diseases.

    DOI: 10.3390/ijms26051883

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  • Real-World Setting of Efficacy and Safety of 3 Years of Rifaximin Administration in Japanese Patients with Hepatic Encephalopathy: A Multicenter Retrospective Study. International journal

    Hideto Kawaratani, Tadashi Namisaki, Yasuteru Kondo, Ryoji Tatsumi, Naoto Kawabe, Norikazu Tanabe, Akira Sakamaki, Kyoko Hoshikawa, Yoshihito Uchida, Kei Endo, Takumi Kawaguchi, Tsunekazu Oikawa, Yoji Ishizu, Shuhei Hige, Taro Takami, Shuji Terai, Yoshiyuki Ueno, Satoshi Mochida, Kazuhiko Koike, Hitoshi Yoshiji

    Journal of clinical medicine   14 ( 4 )   2025.2

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    Background/Objectives: Rifaximin is a therapeutic agent for patients with hepatic encephalopathy (HE); however, there is little data on the effects of its long-term (>1 year) administration in Japanese patients with cirrhosis. The effects and safety of 3-year rifaximin treatment on HE was investigated in Japan. Methods: A total of 190 Japanese patients with cirrhosis who were continuously administered rifaximin for more than 1 year suffered overt or covert HE, which was diagnosed by a physician. Laboratory data were collected at baseline, 3, 6, 12, 18, 24, 30, and 36 months following rifaximin administration. We examined the cumulative overt HE incidences, overall survival rates, and hepatic functional reserves following rifaximin treatment. The occurrence of adverse events was also assessed. Results: The levels of ammonia improved significantly after 3 months of rifaximin administration, which continued for 3 years. Serum albumin and prothrombin activity also significantly improved 3 years after initiation of rifaximin treatment. Cumulative overt HE incidences were 12.1%, 19.7%, and 24.9% at 1, 2, and 3 years, respectively. The survival rates following rifaximin treatment were 100%, 88.9%, and 77.8% at 1, 2, and 3 years, respectively. In contrast, renal function and electrolytes did not change following rifaximin administration. Only three (1.6%) patients discontinued rifaximin therapy because of severe diarrhea after 1 year of rifaximin administration. No other serious adverse events were observed. Conclusions: Three years of continuous rifaximin (RFX) treatment was both effective and safe for patients with hepatic encephalopathy. Liver function improved and did not worsen during treatment.

    DOI: 10.3390/jcm14041358

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  • Combination therapies with immune checkpoint inhibitor-based combination therapies for hepatocellular carcinoma with major vascular invasion. International journal

    Tatsuo Kanda, Reina Sasaki-Tanaka, Shuji Terai

    Hepatology international   2025.2

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  • Correction: Watanabe et al. Pemafibrate Improves Alanine Aminotransferase Levels Independently of Its Lipid-Lowering Effect. <i>Livers</i> 2023, <i>3</i>, 562–568

    Azuma Watanabe, Ryoko Horigome, Yumiko Nakatsuka, Shuji Terai

    Livers   2025.2

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    DOI: 10.3390/livers5010010

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  • Hepatitis B virus infection and its treatment in Eastern Ethiopia International journal

    Tatsuo Kanda, Reina Sasaki-Tanaka, Atsunori Tsuchiya, Shuji Terai

    World Journal of Hepatology   17 ( 1 )   99209 - 99209   2025.1

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    Hepatitis B virus (HBV) infection causes acute and chronic hepatitis, compensated and decompensated cirrhosis, and hepatocellular carcinoma worldwide. The actual status of HBV infection and its treatment in certain regions of Asian and African countries, including Ethiopia, has not been well-documented thus far. Antiviral therapy for HBV infection can prevent the progression of HBV-related liver diseases and decrease the HBV-related symptoms, such as abdominal symptoms, fatigue, systemic symptoms and others. In Eastern Ethiopia, HBV-infected patients with cirrhosis were found to be positive for the HBV e antigen and to have a higher viral load than those without cirrhosis. Notably, 54.4% of patients practiced khat chewing and 18.1% consumed excessive amounts of alcohol. Tenofovir disoproxil fumarate effectively suppressed HBV DNA in those infected with HBV. It is important to elucidate the actual status of HBV infection in Eastern Ethiopia to eliminate HBV infection worldwide by 2030. HBV vaccination and the educational programs for Health Science students that provide practical strategies could help to reduce HBV infection in Eastern Ethiopia.

    DOI: 10.4254/wjh.v17.i1.99209

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  • Aligning cellular and molecular components in age-dependent tertiary lymphoid tissues of kidney and liver. International journal

    Naoya Toriu, Yuki Sato, Hiroteru Kamimura, Takahisa Yoshikawa, Masaou Tanaka, Shinya Yamamoto, Shingo Fukuma, Masakazu Hattori, Shuji Terai, Motoko Yanagita

    PloS one   20 ( 2 )   e0311193   2025

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    Tertiary lymphoid tissues (TLTs) are ectopic lymphoid structures induced by multiple stimuli, including infection and tissue injuries; however, their clinical relevance in disease progression has remained unclear. We demonstrated previously that TLTs develop in mouse and human kidneys with aging and can be a potential marker of kidney injury and prognosis, and therapeutic targets. In addition, we found that two types of unique lymphocytes that emerge with aging, senescence-associated T cells and age-associated B cells, are essential for TLT formation in the kidney. Although TLTs develop with aging in other organs as well, their cellular and molecular components, and clinical significance remain unclear. In the present study, we found that TLTs developed in the liver with aging, and that their cellular and molecular components were similar to those in the kidneys. Notably, senescence-associated T cells and age-associated B cells were also present in hepatic TLTs. Furthermore, analysis of publicly available data on human liver biopsy transcriptomes revealed that the expression of TLT-related genes was elevated in the liver biopsy samples from hepatitis C virus (HCV)-infected patients compared with those without HCV infection and was associated with liver injury and fibrosis. Therefore, we analyzed liver biopsy samples from 47 HCV patients and found that TLTs were present in 87.2% of cases and that the numbers and stages of TLTs were higher in aged patients and cellular and molecular components of TLTs in humans were similar to those in mice. Our findings suggesting that age-dependent TLT formation is a systemic phenomenon across the tissues and aging is also a predisposing factor for TLT formation across organs.

    DOI: 10.1371/journal.pone.0311193

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  • Enrichment of Porphyromonas gingivalis in colonic mucosa-associated microbiota and its enhanced adhesion to epithelium in colorectal carcinogenesis: Insights from in vivo and clinical studies. International journal

    Shunya Motosugi, Naoki Takahashi, Shuhei Mineo, Keisuke Sato, Takahiro Tsuzuno, Yukari Aoki-Nonaka, Nao Nakajima, Kazuya Takahashi, Hiroki Sato, Haruna Miyazawa, Koji Taniguchi, Shuji Terai, Koichi Tabeta

    PloS one   20 ( 3 )   e0320383   2025

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    OBJECTIVES: The oral-gut axis is believed to play a role in the pathogenesis of colorectal cancer (CRC). Previous studies have demonstrated the transmission of oral microbiota to the gut, disrupting gut microbial balance and creating a protumorigenic microenvironment conducive to CRC progression. Fusobacterium nucleatum is a putative periodontal pathogen recognized as a specific bacterium that promotes CRC development. However, the possible involvement of other periodontal pathogens in CRC is poorly understood. This study aimed to explore the effects of ingested periodontal pathogens on experimental CRC in mice and elucidate the underlying mechanisms. METHODS: In this study, experimental colitis-induced CRC mouse models were used. The mice were orally administered periodontal pathogens (Porphyromonas gingivalis and Prevotella intermedia) three times a week during the experimental period. The CRC severity between the P. gingivalis-treated and P. intermedia-treated groups was compared. Lumen-associated microbiota (LAM) and mucosa-associated microbiota (MAM) were analyzed in both mouse and human samples. In vitro studies were conducted using intestinal epithelial cells to explore the possible mechanisms by which the periodontal pathogens affect the CRC development. RESULTS: The P. gingivalis-treated group exhibited significantly increased CRC severity compared to the other groups among azoxymethane/dextran sodium sulfate (AOM/DSS)-induced mouse models. The LAM and MAM exhibited distinct bacterial compositions, and P. gingivalis was enriched more in MAM than in LAM. In vitro adhesion assays revealed that P. gingivalis had higher adhesive capacity to intestinal epithelial cells than P. intermedia and indicated the possible involvement of gingipains in such a capacity. CONCLUSION: P. gingivalis is enriched in MAM, and its subsequent adhesion to intestinal epithelial cells is potentially involved in the progression of CRC.

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  • Persistent body-weight change on achalasia and peroral endoscopic myotomy: a multicenter cohort study.

    Kazuya Takahashi, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Takuya Satomi, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Shuji Terai, Haruhiro Inoue

    Journal of gastroenterology   2024.12

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    BACKGROUND: The distribution of body weight in patients with achalasia and after peroral endoscopic myotomy (POEM) has not been investigated. The role of body weight assessment after treatment remains unclear. METHODS: Using the multicenter achalasia cohort, the frequency of underweight (body mass index [BMI] < 18.5 kg/m2) and overweight (BMI ≥ 25.0 kg/m2) and their associated clinical characteristics were analyzed. After POEM, risk factors for insufficient- (underweight persistently) and excessive- (responded to overweight) weight gainers were investigated. The correlation between BMI-increase rate and severity of esophageal symptoms post-POEM was evaluated. RESULTS: Among 3,410 patients, 23.0% and 15.7% were underweight and overweight, respectively. Factors associated with underweight were higher age, female sex, severe symptoms, high lower esophageal sphincter (LES) pressure, and non-dilated esophagus (all p < 0.01). Longitudinal analyses revealed that weight gain post-POEM was achieved after a long duration (≥ 12 months; p < 0.01). In 528 patients post-POEM, the frequency of underweight reduced to 8.3% (p < 0.01). Risk factors for insufficient-weight gain (36.1% of underweight patients) included low BMI (p < 0.01) and high LES pressure (p = 0.03) and conversely for excessive-weight gain. Machine learning models based on patient characteristics successfully predicted insufficient- and excessive-weight gainers with an area under the curve value of 0.74 and 0.75, respectively. Esophageal symptoms post-POEM did not correlate with BMI increase. CONCLUSION: Underweight is not solely a condition of advanced achalasia. After POEM, insufficient- or excessive-weight gainers are not rare and can be predicted preoperatively. Body weight change is an independent nutrition parameter rather than a part of the assessment of residual esophageal symptoms.

    DOI: 10.1007/s00535-024-02205-9

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  • Dasatinib and Quercetin as Senolytic Drugs Improve Fat Deposition and Exhibit Antifibrotic Effects in the Medaka Metabolic Dysfunction-Associated Steatotic Liver Disease Model. International journal

    Shunta Yakubo, Hiroyuki Abe, Yawen Li, Marina Kudo, Atsushi Kimura, Takuya Wakabayashi, Yusuke Watanabe, Naruhiro Kimura, Toru Setsu, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Atsunori Tsuchiya, Kenya Kamimura, Shuji Terai

    Diseases (Basel, Switzerland)   12 ( 12 )   2024.12

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    Metabolic dysfunction-associated steatotic liver disease (MASLD) causes cellular senescence due to oxidative stress, endoplasmic reticulum stress, and ectopic fat deposition in the liver. Recently, dasatinib, an antitumor agent, and quercetin, a dietary supplement, were combined as a senolytic drug to eliminate senescent cells. Thus, this study aimed to examine the effects of dasatinib and quercetin administration on removing senescent cells and their therapeutic effects on MASLD in a medaka MASLD model. Dasatinib and quercetin were administered to a medaka MASLD model, which was fed a high-fat diet by dissolving them in aquarium water. The results revealed that senescent cells in the liver were increased in the HFD group but improved in the treatment group. Hematoxylin and eosin staining also showed that treatment improved fat deposition in hepatocytes. In addition, TGFβ1, a driver factor of fibrosis, was reduced in the treatment group. Dasatinib and quercetin eliminated senescent cells in MASLD, attenuated fat deposition, and suppressed fibrosis gene expression. The results indicate that dasatinib and quercetin as senolytic drugs are novel therapeutic agents that reduce MASLD.

    DOI: 10.3390/diseases12120317

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  • ROI Selection to Improve Prediction Performance of CNN for Cirrhosis Detection Using Ultrasound Images Reviewed

    Kazuma Nakata, Yusuke Fujita, Yoshihiro Mitani, Yoshihiko Hamamoto, Makoto Segawa, Shuji Terai

    2024 IEEE 13th Global Conference on Consumer Electronics (GCCE)   636 - 640   2024.11

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    DOI: 10.1109/GCCE62371.2024.10760734

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  • Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy. International journal

    Yuki Tahata, Hayato Hikita, Satoshi Mochida, Nobuyuki Enomoto, Norifumi Kawada, Akio Ido, Daiki Miki, Masayuki Kurosaki, Hitoshi Yoshiji, Ryotaro Sakamori, Hidekatsu Kuroda, Hiroshi Yatsuhashi, Taro Yamashita, Yoichi Hiasa, Naoya Kato, Hisamitsu Miyaaki, Yoshiyuki Ueno, Yoshito Itoh, Kentaro Matsuura, Taro Takami, Yasuhiro Asahina, Goki Suda, Norio Akuta, Ryosuke Tateishi, Yasunari Nakamoto, Eiji Kakazu, Shuji Terai, Masahito Shimizu, Masanori Miyazaki, Yasutoshi Nozaki, Satoshi Sobue, Hiroki Yano, Tomokatsu Miyaki, Akihiro Moriuchi, Takeshi Hori, Kumiko Shirai, Kazuhiro Murai, Yoshinobu Saito, Takahiro Kodama, Tomohide Tatsumi, Tomomi Yamada, Tetsuo Takehara

    Hepatology research : the official journal of the Japan Society of Hepatology   2024.10

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    AIM: The incidence of and factors involved in gastroesophageal varix-related events in hepatitis C virus-related cirrhosis patients, including decompensated cirrhosis, after direct-acting antiviral therapy are unclear. METHODS: We conducted a multicenter study using prospective data from 478 hepatitis C virus-related cirrhosis patients treated with direct-acting antiviral therapy from February 2019 to December 2021 at 33 Japanese hospitals. Gastroesophageal varices were classified as F1 (small-caliber), F2 (moderately enlarged), or F3 (markedly enlarged) according to the Japanese criteria. Patients without varix or with F1 without red color signs were defined as low-risk varix, and patients with ≥F2 or red color signs or a history of rupture were defined as high-risk varix. Varix-related events were defined as prophylactic treatment or rupture of gastroesophageal varix. RESULTS: The median age was 70 years, 43% of patients had decompensated cirrhosis, and 16% had high-risk varices (13% in compensated and 33% in decompensated, p < 0.001). Sustained virologic response rates were 94.9% for compensated cirrhosis and 91.3% for decompensated cirrhosis (p = 0.120). Across 35.7 months, 25 patients received prophylactic treatment, and four experienced varix rupture. The 3-year incidence rate of varix-related events was 6.2% (3.5% in compensated and 9.9% in decompensated, p = 0.001). In the multivariate analysis, high-risk varix (p < 0.001), high baseline gamma-glutamyl transpeptidase levels (p < 0.001), and virologic failure (p = 0.004) were significantly involved in varix-related events. CONCLUSIONS: The cumulative incidence rate of varix-related events was significantly higher in decompensated cirrhosis than in compensated cirrhosis. Baseline varix status, baseline gamma-glutamyl transpeptidase levels, and virologic response were related to varix-related events after direct-acting antiviral therapy.

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  • Association between Clinical Characteristics and Sarcopenia or Sarcopenic Obesity in Crohn's Disease.

    Takumi Naruse, Hiroki Sato, Kazuya Takahashi, Chihiro Sato, Yuichi Kojima, Yuzo Kawata, Kentaro Tominaga, Ken-Ichi Mizuno, Shuji Terai

    Internal medicine (Tokyo, Japan)   2024.10

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    Objective Crohn's disease (CD) is a chronic inflammatory bowel disease that is associated with malnutrition. Sarcopenia is a malnutrition condition characterized by skeletal muscle loss that impairs the physical function. We investigated the clinical characteristics of patients with CD with sarcopenia and sarcopenic obesity (sarcopenic-o). Methods The body composition of patients with CD was evaluated using a bioelectrical impedance analysis. The clinical characteristics of patients with sarcopenia and sarcopenic-o were analyzed, and a predictive model for sarcopenia was developed. Patients: Patients with CD recruited from 2019 to 2021 were included. Results Among the 104 patients, 35 (33.7%) and 10 (9.6%) had sarcopenia and sarcopenic-o, respectively. In the sarcopenia group, the skeletal muscle index (SMI) and body mass index (BMI) were lower than those in the control group (SMI, 6.3 kg/m2 vs. 7.7 kg/m2, p<0.01; BMI, 18.8 kg/m2 vs. 22.6 kg/m2, p<0.01), whereas the Crohn's disease activity index (CDAI) was higher than in the control group (114.2 vs. 42.0, p<0.01). The predictive models of sarcopenia using the BMI and CDAI revealed high performance with areas under the receiver operating characteristic curve (AUC) of 0.87 and 0.72, respectively, and high specificity (0.94) and sensitivity (0.71), respectively. Sarcopenic-o patients could not be screened using the BMI (25 kg/m2), and the SMI and body fat percentage were negatively correlated in patients with sarcopenia (p<0.01). Conclusion Sarcopenia and sarcopenic-o are relatively common conditions among patients with CD. Sarcopenia can be predicted using the clinical parameters of BMI and CDAI. Sarcopenic-o can be a severe form of sarcopenia.

    DOI: 10.2169/internalmedicine.4420-24

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  • Diffuse Large B-cell Lymphoma with Severe Lactic Acidosis and Liver Failure: A Case Report and Literature Review.

    Shun Yamazaki, Yusuke Watanabe, Kazuya Takahashi, Kentaro Tominaga, Satoshi Ikarashi, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, Shuji Terai

    Internal medicine (Tokyo, Japan)   2024.10

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    Among causes of liver failure, liver failure due to lymphocytic infiltration is rare. Unlike typical liver failure, some cases present with severe lactic acidosis and a poor prognosis. We herein report a case of diffuse large B-cell lymphoma with severe lactic acidosis and liver failure. We further discuss the characteristics of similar cases in the literature, suggesting that intrahepatic infiltration by hematological malignant cells should be considered as a differential diagnosis in the presence of severe lactic acidosis and liver failure. This study underscores the importance of early recognition and serves as a reference for future cases.

    DOI: 10.2169/internalmedicine.4450-24

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  • 治療困難胆管結石に対する経口胆道鏡下治療の有用性

    五十嵐 聡, 林 和直, 柴田 理, 寺井 崇二

    Gastroenterological Endoscopy   66 ( Suppl.2 )   2301 - 2301   2024.10

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  • 「長期臨床経過を見据えた消化器疾患の治療・管理における工夫と課題」 自己免疫性膵炎のステロイド治療導入後再燃例における臨床経過の検証

    田中 裕登, 柴田 理, 五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   75回・97回   51 - 51   2024.10

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  • 非切除肝門部領域胆管癌に対する内視鏡的胆管ステント留置術の検討

    林 和直, 柴田 理, 五十嵐 聡, 寺井 崇二

    Gastroenterological Endoscopy   66 ( Suppl.2 )   2292 - 2292   2024.10

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  • 自験例から考察したHBV de novo再活性化診療のピットフォール

    木村 究, 横尾 健, 吉田 智彰, 渡邉 雄介, 木村 成宏, 阿部 寛幸, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   75回・97回   70 - 70   2024.10

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  • Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice. International journal

    Kyutaro Koyama, Akira Sakamaki, Shinichi Morita, Itsuo Nagayama, Marina Kudo, Yuto Tanaka, Naruhiro Kimura, Yoshihisa Arao, Hiroyuki Abe, Kenya Kamimura, Shuji Terai

    Scientific reports   14 ( 1 )   21126 - 21126   2024.9

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    The onset and progression mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are being studied. We developed and analyzed a new mouse model of obesity by combining maternal Id-like molecule (Maid) and melanocortin-4 receptor (Mc4r) gene deletions. Four mice, each at 12 and 28 weeks of age, were analyzed for each genotype: Maid gene knockout, Mc4r gene knockout, combined Mc4r and Maid gene knockout, and Mc4r gene knockout with a high-fat diet. Mice with a combined deficiency of Mc4r and Maid gene showed significantly more severe obesity compared to all other genotypes, but no liver fibrosis or a decline in metabolic status were observed. In visceral white adipose tissue, Maid and Mc4r gene knockout mice had fewer CD11c-positive cells and lower mRNA expression of both inflammatory and anti-inflammatory cytokines. Furthermore, Maid and Mc4r gene knockout mice showed lower expression of adipocytokines in visceral white adipose tissue and uncoupling protein-1 in scapular brown adipose tissue. The expression of adipocytokines and uncoupling protein-1 is regulated by sympathetic nerve signaling that contribute severe obesity in Maid and Mc4r gene knockout mice. These mechanisms contribute hyperobesity in Maid and Mc4r gene knockout mice.

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  • 症候性巨大肝嚢胞に対する嚢胞内洗浄併用の塩酸ミノサイクリン硬化療法が長期的効果を呈した1例

    小川 和也, 上村 顕也, 石井 壮一, 遠藤 沙織, 石川 夏生, 阿部 寛幸, 坂牧 僚, 寺井 崇二

    日本消化器病学会雑誌   121 ( 9 )   769 - 776   2024.9

  • PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis. International journal

    Yung Ting Hsiao, Yohko Yoshida, Shujiro Okuda, Manabu Abe, Seiya Mizuno, Satoru Takahashi, Hironori Nakagami, Ryuichi Morishita, Kenya Kamimura, Shuji Terai, Tin May Aung, Ji Li, Takaaki Furihata, Jing Yuan Tang, Kenneth Walsh, Akihito Ishigami, Tohru Minamino, Ippei Shimizu

    The EMBO journal   2024.8

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    Metabolic dysfunction-associated steatohepatitis (MASH, previously termed non-alcoholic steatohepatitis (NASH)), is a major complication of obesity that promotes fatty liver disease. MASH is characterized by progressive tissue fibrosis and sterile liver inflammation that can lead to liver cirrhosis, cancer, and death. The molecular mechanisms of fibrosis in MASH and its systemic control remain poorly understood. Here, we identified the secreted-type pro-fibrotic protein, procollagen C-endopeptidase enhancer-1 (PCPE-1), as a brown adipose tissue (BAT)-derived adipokine that promotes liver fibrosis in a murine obesity-induced MASH model. BAT-specific or systemic PCPE-1 depletion in mice ameliorated liver fibrosis, whereas, PCPE-1 gain of function in BAT enhanced hepatic fibrosis. High-calorie diet-induced ER stress increased PCPE-1 production in BAT through the activation of IRE-1/JNK/c-Fos/c-Jun signaling. Circulating PCPE-1 levels are increased in the plasma of MASH patients, suggesting a therapeutic possibility. In sum, our results uncover PCPE-1 as a novel systemic control factor of liver fibrosis.

    DOI: 10.1038/s44318-024-00196-0

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  • Urinary NGAL in gastrointestinal diseases can be used as an indicator of early infection in addition to acute kidney injury marker. International journal

    Yuichi Kojima, Atsunori Tsuchiya, Masaki Mito, Yusuke Watanabe, Yuzo Kawata, Kentaro Tominaga, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   8 ( 8 )   e70009   2024.8

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    BACKGROUND AND AIM: Neutrophil gelatinase-associated lipocalin (NGAL) is characterized by increased expression before the rise in serum creatinine and has been used as a biomarker for the early prediction of acute kidney injury (AKI). However, there have been no comprehensive analyses of its significance in gastrointestinal diseases. This study aimed to analyze the usefulness of measuring urinary NGAL levels in patients with gastrointestinal diseases. METHODS: This study included 171 patients with a wide range of gastrointestinal diseases. Urinary NGAL levels were measured in all patients within 24 h of admission and 72 h later. RESULTS: Urinary NGAL levels were higher in patients with acute pancreatitis and acute cholangitis/cholecystitis than in those with other diseases. Although lower than in these diseases, urinary NGAL tends to be higher in inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, as well as in acute and chronic liver diseases, and is higher in liver cirrhosis as the Child-Pugh grade increases. Furthermore, we found that the group with higher urinary NGAL levels, which continued to increase over time, had worse hospital stays and prognosis. CONCLUSION: Urinary NGAL could be used as an indicator of infectious diseases rather than an indicator of AKI in inflammatory bowel diseases and cirrhosis, and could predict the prognosis of patients with gastrointestinal diseases.

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  • 【肝臓リハビリテーションの現状と問題点】

    寺井 崇二, 吉治 仁志, 川口 巧, 清水 雅仁, 辻 哲也

    肝臓   65 ( 8 )   351 - 367   2024.8

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  • Diagnosis and resolution of olmesartan-associated sprue-like enteropathy confirmed by capsule endoscopy: a case report and literature review.

    Erina Kodama, Yuzo Kawata, Shun Yamazaki, Takanori Igarashi, Yuichi Kojima, Kentaro Tominaga, Junji Yokoyama, Terasu Honma, Shuji Terai

    Clinical journal of gastroenterology   2024.7

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    Herein, we describe a case of olmesartan-associated sprue-like enteropathy, in which improvement in villous atrophy was confirmed using small bowel capsule endoscopy. The patient was a 69-year-old woman who had persistent watery diarrhea (20 bowel movements/day) for 1 year and experienced a weight loss of 10 kg in the same period. Abdominal computed tomography revealed no abnormalities, and blood test results revealed no inflammatory reactions. Upper endoscopy and colonoscopy revealed villous atrophy in the duodenum and terminal ileum. As the patient was administered olmesartan for a long time and capsule endoscopy showed villous atrophy throughout the small bowel, she was diagnosed with olmesartan-associated sprue-like disease. Following the discontinuation of the medication, symptoms of diarrhea soon improved, and repeat capsule endoscopy indicated improvement in small intestinal villous atrophy. Olmesartan-associated sprue-like enteropathy should be considered a differential diagnosis in patients with severe chronic watery diarrhea. Our report is the first in which capsule endoscopy was performed multiple times over a long period for follow-up observation of improvements in the small intestine. In addition, our literature review regarding capsule endoscopy for olmesartan-associated enteritis might aid clinicians in the early diagnosis of the condition and the assessment of treatment efficacy.

    DOI: 10.1007/s12328-024-02023-9

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  • Automatic ROI Selection with Reliability Evaluation Method for Cirrhosis Detection using Ultrasound Images Reviewed

    Kazuma Nakata, Yusuke Fujita, Yoshihiro Mitani, Yoshihiko Hamamoto, Makoto Segawa, Shuji Terai, Isao Sakaida

    IEEJ Transactions on Electrical and Electronic Engineering   19 ( 7 )   2024.7

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    DOI: 10.1002/tee.24070

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  • Inflammation of the liver, HCC development and HCC establishment Invited Reviewed

    Tatsuo Kanda, Reina Sasaki-Tanaka, Shuji Terai

    Hepatology International   2024.6

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    DOI: 10.1007/s12072-024-10707-0

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  • Fibulin-4 as a potential extracellular vesicle marker of fibrosis in patients with cirrhosis. International journal

    Masaru Kumagai, Atsunori Tsuchiya, Yuan Yang, Nobutaka Takeda, Kazuki Natsui, Yui Natusi, Kei Tomiyoshi, Fusako Yamazaki, Yohei Koseki, Hiroki Shinchi, Naoko Imawaka, Ryo Ukekawa, Takahiro Nishibu, Hiroyuki Abe, Takako Sasaki, Koji Ueda, Shuji Terai

    FEBS open bio   2024.6

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    Chronic liver injury leads to decreased liver function and increased fibrosis. Fibrosis is not only associated with the development of portal hypertension and carcinogenesis, but with the occurrence of events and a poor prognosis, highlighting the importance of non-invasive fibrosis assessment in patients. In the present study, we searched for markers related to liver fibrosis via proteomic analysis of small extracellular vesicles (sEVs). In the discovery cohort, proteomic analysis was carried out in the sEVs extracted from the sera of 5 patients with decompensated cirrhosis, 5 patients with compensated cirrhosis, and 5 controls without liver disease. Interestingly, in this cohort, fibulin-4 was significantly associated with cirrhosis while in the validation cohort [formed by 191 patients: 7 patients without disease, 16 patients without liver disease (other diseases), 38 patients with chronic liver disease (CLD), 75 patients with cirrhosis of Child-Pugh class A (36 without hepatocellular carcinoma [HCC], 29 with HCC), and 65 patients with cirrhosis of Child-Pugh class B-C (39 without HCC, 26 with HCC)], fibulin-4/CD9 levels increased with cirrhosis progression. Furthermore, the fibulin-4/CD9 ratio was significantly higher in patients with varices. Immunostaining also revealed strong fibulin-4 expression in cholangiocytes within the fibrous areas and mesothelial cells in liver tissue blood vessels. Taken together, our results suggest that fibulin-4, essential for lysyl oxidase activation, might be a new liver fibrosis marker found in the sEVs of patients with cirrhosis.

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  • 胆膵内視鏡検査・治療における工夫とトラブルシューティング 当院における副乳頭アプローチカニュレーション

    名古屋 拓郎, 小川 光平, 五十嵐 聡, 林 和直, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   39 ( 2 )   154 - 154   2024.6

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  • IgG4関連疾患における診断・治療困難例に対する取り組み 自己免疫性膵炎のステロイド治療導入後再燃例における臨床経過の検証

    小川 光平, 名古屋 拓郎, 五十嵐 聡, 林 和直, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   39 ( 2 )   148 - 148   2024.6

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  • Platelet-rich plasma-derived extracellular vesicles improve liver cirrhosis in mice. International journal

    Yuichirou Maeda, Yusuke Watanabe, Natsuki Ishikawa, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    Regenerative therapy   26   1048 - 1057   2024.6

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    INTRODUCTION: Cirrhosis remains a significant clinical challenge due to its poor prognosis and limited treatment options, creating a high unmet medical need for the development of novel therapies. In this study, we analyzed the effects of a novel approach to treat cirrhosis using platelet-rich plasma-derived extracellular vesicles (PRPEV) in mice. METHODS: PRPEV were collected from platelet-rich plasma using ultrafiltration, and their proteomes were analyzed. The carbon tetrachloride (CCl4)-induced cirrhosis model of mice was used to evaluate the effect of PRPEV administration and compared with the control group (n = 8). In vitro and in vivo mechanistic analyses of PRPEV administration were confirmed using real time-PCR and immunostaining. RESULTS: Gene ontology analysis based on the proteome revealed that PRPEV contain many factors associated with EV and immune responses. In vitro, PRPEV polarize macrophages into an anti-inflammatory phenotype. Following PRPEV administration, there was a decrease in serum alanine aminotransferase levels and reduction in liver fibrosis, while mRNA levels of regenerative factors were upregulated and transforming growth factor β-1 was downregulated. Furthermore, the number of anti-inflammatory macrophages in the liver increased. CONCLUSIONS: PRPEV may contribute to hepatocyte proliferation, anti-inflammation, and anti-fibrogenesis in the liver. This novel concept paves the way for cirrhosis treatment.

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  • 胆膵内視鏡検査・治療における工夫とトラブルシューティング 当院における副乳頭アプローチカニュレーション

    名古屋 拓郎, 小川 光平, 五十嵐 聡, 林 和直, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   39 ( 2 )   154 - 154   2024.6

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  • IgG4関連疾患における診断・治療困難例に対する取り組み 自己免疫性膵炎のステロイド治療導入後再燃例における臨床経過の検証

    小川 光平, 名古屋 拓郎, 五十嵐 聡, 林 和直, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   39 ( 2 )   148 - 148   2024.6

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  • Novel scale for evaluating the therapeutic efficacy of per-oral endoscopic myotomy in achalasia.

    Kazuya Takahashi, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Kenta Hamada, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Shuji Terai, Haruhiro Inoue

    Journal of gastroenterology   2024.5

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    BACKGROUND: Symptom scales for achalasia after per-oral endoscopic myotomy (POEM) are lacking. This study aimed to propose a new scale based on the conventional Eckardt score (c-ES) and evaluate persistent symptoms that impair patients' quality of life (QOL) post-POEM. METHODS: Dysphagia, regurgitation, and chest pain frequencies were assessed using a 6-point scale modified-ES (m-ES) after POEM, with "occasional" symptoms on the c-ES further subdivided into three-period categories on m-ES. Symptom severity was further evaluated using a 5-point scale ranging from 1 to 5 points, with a score ≥ 3 points defined as persistent symptoms impairing QOL. We analyzed the correlation between the m-ES and severity score, diagnostic performance of the m-ES for persistent symptoms, and overlaps between each residual symptom. RESULTS: Overall, 536 patients (median follow-up period, 2.9 years) post-POEM were included in this multicenter study. Significant correlations were observed between the m-ES and severity scores for dysphagia (r = 0.67, p < 0.01), regurgitation (r = 0.73, p < 0.01), and chest pain (r = 0.85, p < 0.01). Twenty-six patients (4.9%) had persistent symptoms post-POEM, and 23 of them had m-ES-specific symptom frequency ≥ once a month, which was determined as the optimal frequency threshold for screening persistent symptoms. The total m-ES predicted persistent symptoms more accurately than the total c-ES (area under the curve: 0.95 vs. 0.79, p < 0.01). Furthermore, dysphagia and chest pain were the major residual symptoms post-POEM covering 91.4% of regurgitation. CONCLUSIONS: The new post-POEM scale successfully evaluated the QOL-based patient symptom severities. Our study implied the possibility of a simpler scale using residual dysphagia and chest pain.

    DOI: 10.1007/s00535-024-02119-6

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  • Liver Diseases: From Bench to Bedside Invited Reviewed

    Tatsuo Kanda, Reina Sasaki-Tanaka, Shuji Terai

    International Journal of Molecular Sciences   25 ( 10 )   5454   2024.5

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    DOI: 10.3390/ijms25105454

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  • Acute on chronic liver failureモデルに対する肝細胞老化除去治療の基礎的検討

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    肝臓   65 ( 5 )   252 - 252   2024.5

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  • 消化器救急疾患における診断・治療と課題 当院における重症急性膵炎の予後・感染性被包化膵壊死合併の検討

    柴田 理, 林 和直, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   74回・96回   35 - 35   2024.5

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  • A rare cause of esophageal stenosis: Compression due to a thoracic osteophyte. International journal

    Suguru Miida, Yoshihisa Arao, Nobutaka Takeda, Shu Goto, Yuichi Kojima, Naruhiro Kimura, Kazunao Hayashi, Atsunori Tsuchiya, Shuji Terai

    DEN open   4 ( 1 )   e260   2024.4

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    Several cases of esophageal stenosis caused by cervical vertebral osteophytes have been reported; however, few reports of esophageal stenosis caused by thoracic osteophytes are available. We describe the case of an 86-year-old man with esophageal stenosis caused by a thoracic osteophyte near the tracheal bifurcation. An endoscopic ultrasonography examination was scheduled to determine the cause of acute pancreatitis; however, lacerations observed at the bifurcation following endoscope removal during prior esophagogastroduodenoscopy led us to cancel the ultrasonography to avoid potential esophageal perforation. A review of the present case and six similar previous cases of thoracic osteophyte-associated esophageal stenosis (identified via a systematic search of the PubMed database) demonstrated the clinical importance of a thoracic osteophyte near physiological esophageal stenosis. Esophagogastroduodenoscopy and computed tomography should be performed to screen for vertebral osteophytes before endoscopic ultrasonography, endoscopic retrograde cholangiopancreatography, and transesophageal echocardiography to avoid iatrogenic accidents.

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  • ダサチニブ及びケルセチンは老化細胞除去剤としてMASHメダカモデルにおいて老化細胞を減少させ病態改善に寄与する

    阿部 寛幸, 弥久保 俊太, 渡邉 雄介, 木村 成宏, 横尾 健, 坂牧 僚, 上村 博輝, 土屋 淳紀, 上村 顕也, 寺井 崇二

    肝臓   65 ( Suppl.1 )   A514 - A514   2024.4

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  • Portal biliopathyにより胆管消失症候群を来したと考えられる一例

    木村 究, 上村 博輝, 渡邉 雄介, 五十嵐 聡, 土屋 淳紀, 寺井 崇二, 佐久間 康成, 大西 康晴, 眞田 幸弘, 脇屋 太一, 平田 雄大, 大豆生田 尚彦

    肝臓   65 ( Suppl.1 )   A301 - A301   2024.4

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  • 顕性肝性脳症の発症予測における,呼気中水素・メタン分析によるSIBO診断の有用性の検討

    坂牧 僚, 横山 邦彦, 若林 拓哉, 阿部 寛幸, 土屋 淳紀, 上村 顕也, 寺井 崇二

    肝臓   65 ( Suppl.1 )   A410 - A410   2024.4

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  • 再生と老化研究のCutting edge-臨床への展開を踏まえて- S-005151の慢性肝疾患患者を対象にした第2相医師主導治験での線維化改善と肝機能改善効果の検証

    土屋 淳紀, 阿部 寛幸, 寺井 崇二

    肝臓   65 ( Suppl.1 )   A78 - A78   2024.4

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  • 顕性肝性脳症の発症予測における,呼気中水素・メタン分析によるSIBO診断の有用性の検討

    坂牧 僚, 横山 邦彦, 若林 拓哉, 阿部 寛幸, 土屋 淳紀, 上村 顕也, 寺井 崇二

    肝臓   65 ( Suppl.1 )   A410 - A410   2024.4

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  • ダサチニブ及びケルセチンは老化細胞除去剤としてMASHメダカモデルにおいて老化細胞を減少させ病態改善に寄与する

    阿部 寛幸, 弥久保 俊太, 渡邉 雄介, 木村 成宏, 横尾 健, 坂牧 僚, 上村 博輝, 土屋 淳紀, 上村 顕也, 寺井 崇二

    肝臓   65 ( Suppl.1 )   A514 - A514   2024.4

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  • メダカを用いた脂肪性肝疾患の多臓器合併症の検討

    上村 顕也, 大越 麻理奈, 木村 淳史, 寺井 崇二

    肝臓   65 ( Suppl.1 )   A332 - A332   2024.4

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  • オルガノイドが切り拓く消化器病研究新時代 組織常在型マクロファージを有する新規小腸オルガノイドの開発

    冨永 顕太郎, Wells James, 寺井 崇二

    日本消化器病学会雑誌   121 ( 臨増総会 )   A186 - A186   2024.3

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  • 小腸腫瘍の内視鏡診断・治療の最前線 当院における原発性小腸癌13例の臨床的特徴

    小島 雄一, 川田 雄三, 冨永 顕太郎, 寺井 崇二

    日本消化器病学会雑誌   121 ( 臨増総会 )   A77 - A77   2024.3

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  • 当院における慢性膵炎に伴う膵仮性嚢胞の合併症治療

    林 和直, 五十嵐 聡, 寺井 崇二

    日本消化器病学会雑誌   121 ( 臨増総会 )   A334 - A334   2024.3

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  • 【膵癌基礎研究の最前線RELOADED】臓器選択的ハイドロダイナミック遺伝子導入法によるラット膵癌モデルの作製

    柴田 理, 上村 顕也, 寺井 崇二

    胆と膵   45 ( 2 )   123 - 126   2024.2

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  • 【慢性肝臓病の克服を目指して】肝臓リハビリテーションと再生医療の開発状況

    上村 博輝, 土屋 淳紀, 寺井 崇二

    日本内科学会雑誌   113 ( 1 )   69 - 75   2024.1

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  • An updated review on the treatment for diversion colitis and pouchitis, with a focus on the utility of autologous fecal microbiota transplantation and its relationship with the intestinal microbiota.

    Kentaro Tominaga, Yuichi Kojima, Yuzo Kawata, Kazuya Takahashi, Hiroki Sato, Atsunori Tsuchiya, Kenya Kamimura, Shuji Terai

    Bioscience of microbiota, food and health   43 ( 3 )   162 - 169   2024

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    Diversion colitis (DC) is characterized by mucosal inflammation in the defunctioned segment of the colon following a colostomy or ileostomy. The major causes of DC are an increase in the number of aerobic bacteria, a lack of short-chain fatty acids (SCFAs), and immune disorders in the diverted colon. However, its exact pathogenesis remains unknown. Various treatment strategies for DC have been explored, although none have been definitively established. Treatment approaches such as SCFAs, 5-aminosalicylic acid enemas, steroid enemas, and irrigation with fibers have been attempted, yielding various degrees of efficacies in mitigating mucosal inflammation. However, only individual case reports demonstrating the limited effect of the following therapies have been published: leukocytapheresis, dextrose (hypertonic glucose) spray, infliximab, an elemental diet, and coconut oil. The usefulness of probiotics for treating DC has recently been reported. Furthermore, fecal microbiota transplantation (FMT) has emerged as a promising treatment for DC. This review provides an update on the treatment strategies of DC, with a particular focus on FMT and its relationship with the intestinal microbiota. FMT may become the first choice of treatment for some patients in the future because of its low medical costs, ease of use, and minimal side effects. Furthermore, FMT can also be used for postoperative DC prophylaxis.

    DOI: 10.12938/bmfh.2024-014

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  • [A case of long-term efficacy of minocycline hydrochloride sclerotherapy combined with intra-cystic lavage for a symptomatic giant liver cyst].

    Kazuya Ogawa, Kenya Kamimura, Soichi Ishii, Saori Endo, Natsuki Ishikawa, Hiroyuki Abe, Akira Sakamaki, Shuji Terai

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   121 ( 9 )   769 - 776   2024

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    Herein, we report a case of a man with a large symptomatic hepatic cyst that gradually enlarged over a follow-up period of 15 years, which eventually caused epigastric fullness and obstructive jaundice. The patient underwent percutaneous cystic drainage followed by sclerotherapy using minocycline hydrochloride combined with intracystic lavage. The treatment resulted in a significant reduction in the hepatic cyst size, symptom improvement, and absence of recurrence for 670 days.

    DOI: 10.11405/nisshoshi.121.769

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  • Correction: Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver. International journal

    Masayoshi Ko, Kenya Kamimura, Takashi Owaki, Takuro Nagoya, Norihiro Sakai, Itsuo Nagayama, Yusuke Niwa, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Ryosuke Inoue, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Shuji Terai

    Disease models & mechanisms   16 ( 12 )   2023.12

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  • Solid pseudopapillary neoplasm in a woman presenting with acute pancreatitis: a case report and review of literature.

    Soichi Ishii, Hiroyuki Abe, Saori Endo, Shuhei Kondo, Nao Nakajima, Kazunao Hayashi, Akira Sakamaki, Takashi Kobayashi, Hajime Umezu, Shuji Terai

    Clinical journal of gastroenterology   16 ( 6 )   937 - 941   2023.12

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    Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor that typically affects young women in the body and tail of the pancreas. SPN is often asymptomatic in the early stages, so it is initially discovered as a large tumor. In this report, we experienced a case of a relatively small SPN discovered in the setting of acute pancreatitis. Because there have been few reports of SPN being discovered in the situation like our case, we report this case based on a review of the literature.

    DOI: 10.1007/s12328-023-01850-6

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  • 【消化器領域における再生医療の現状と展望】間葉系幹細胞,細胞外小胞,ペプチドを用いた肝線維化改善・再生療法を目指して

    土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   120 ( 12 )   973 - 979   2023.12

  • MC4R、Maid両遺伝子欠損マウスを用いた慢性アルコール性肝障害モデルマウスの開発

    坂牧 僚, 酒井 規裕, 小川 和也, 木村 成宏, 荒生 祥尚, 阿部 寛幸, 上村 顕也, 寺井 崇二

    アルコールと医学生物学   42   44 - 46   2023.12

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  • MC4R、Maid両遺伝子欠損マウスを用いた慢性アルコール性肝障害モデルマウスの開発

    坂牧 僚, 酒井 規裕, 小川 和也, 木村 成宏, 荒生 祥尚, 阿部 寛幸, 上村 顕也, 寺井 崇二

    アルコールと医学生物学   42   44 - 46   2023.12

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  • EUS-FNAが診断に有用であった原発性舌下腺癌に合併した多発膵腫瘍の1例

    渡邊 誠, 五十嵐 聡, 渡邊 浩太朗, 山崎 駿, 酒井 規裕, 渡邉 雄介, 冨永 顕太郎, 高橋 一也, 上村 博輝, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   73回・95回   68 - 68   2023.11

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  • 炎症性腸疾患に対する新規治療とバイオ治療再考 多剤使用歴のある潰瘍性大腸炎難治例の臨床的特徴

    小島 雄一, 川田 雄三, 冨永 顕太郎, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   73回・95回   41 - 41   2023.11

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  • 小腸内細菌異常増殖症(SIBO)の病態と臨床 顕性肝性脳症の発症予測における、呼気中水素・メタン分析によるSIBO診断の有用性の検討

    坂巻 僚, 横山 邦彦, 若林 拓哉, 小島 雄一, 川田 雄三, 冨永 顕太郎, 水野 研一, 上村 顕也, 寺井 崇二

    日本小腸学会学術集会プログラム・抄録集   61回   26 - 26   2023.11

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  • 小腸内細菌異常増殖症(SIBO)の病態と臨床 顕性肝性脳症の発症予測における、呼気中水素・メタン分析によるSIBO診断の有用性の検討

    坂巻 僚, 横山 邦彦, 若林 拓哉, 小島 雄一, 川田 雄三, 冨永 顕太郎, 水野 研一, 上村 顕也, 寺井 崇二

    日本小腸学会学術集会プログラム・抄録集   61回   26 - 26   2023.11

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  • Achalasia phenotypes and prediction of per-oral endoscopic myotomy outcomes using machine learning. International journal

    Kazuya Takahashi, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Kenta Hamada, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shuji Terai, Haruhiro Inoue

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   2023.10

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    OBJECTIVES: High-resolution manometry (HRM) and esophagography are used for achalasia diagnosis; however, achalasia phenotypes combining esophageal motility and morphology are unknown. Moreover, predicting treatment outcomes of per-oral endoscopic myotomy (POEM) in treatment-naïve patients remains an unmet need. METHODS: In this multicenter cohort study, we included 1,824 treatment-naïve patients diagnosed with achalasia. In total, 1,778 patients underwent POEM. Clustering by machine learning (ML) was conducted to identify achalasia phenotypes using patients' demographic data, including age, sex, disease duration, body mass index, and HRM/esophagography findings. ML models were developed to predict persistent symptoms (Eckardt score ≥3) and reflux esophagitis (RE) (Los Angeles grades A to D) after POEM. RESULTS: ML identified three achalasia phenotypes: phenotype 1, type I achalasia with a dilated esophagus (n=676; 37.0%); phenotype 2, type II achalasia with a dilated esophagus (n=203; 11.1%); phenotype 3, late-onset type I-III achalasia with a non-dilated esophagus (n=619, 33.9%). Types I and II achalasia in phenotypes 1 and 2 exhibited different clinical characteristics from those in phenotype 3, implying different pathophysiologies within the same HRM diagnosis. A predictive model for persistent symptoms exhibited an area under the curve (AUC) of 0.70. Pre-POEM Eckardt score ≥6 was the greatest contributing factor for persistent symptoms. The AUC for post-POEM RE was 0.61. CONCLUSION: Achalasia phenotypes combining esophageal motility and morphology indicated multiple disease pathophysiologies. ML helped develop an optimal risk stratification model for persistent symptoms with novel insights into treatment resistance factors.

    DOI: 10.1111/den.14714

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  • Improving diagnostic performance of coronavirus disease 2019 rapid antigen testing through computer-based feedback training using open-source experimental psychology software. International journal

    Masato Matsuda, Kosuke Itoh, Takahiro Sugai, Yoshiki Hoshiyama, Toshiaki Kikuchi, Shuji Terai

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2023.10

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    INTRODUCTION: Rapid antigen testing (RAT) results are visually read as whether colored line is present or absent. The subjective interpretation potentially misses detecting weak lines due to lower analyte concentration in samples tested, requiring training. Although routine test experience has improved the result readout skills, it consumes time and resources. Therefore, we created a computer-based feedback training method using open-source experimental psychology software, wherein participants accumulate RAT result readout experience by repeatedly responding positive/negative to randomly presented pictures showing RAT results; then, they receive feedback on their answers as correct or incorrect and are asked to stare at the pictures again with the knowledge of correct answer. This study aimed to examine the training effects in improving the skills, using coronavirus disease 2019 (COVID-19) RAT. METHODS: Twenty-two medical technologists were randomly divided into two groups: the feedback-training and test-experience groups. Using several pictures showing positive and negative results of COVID-19 RAT, after examination of their initial result readout skills, feedback-training group received the feedback training, whereas test-experience group performed an equal number of tests without feedback to accumulate test experience, and their skills were examined again. The ratio of "positive" answers to the pictures showing positive results (i.e., hit rate) was statistically analyzed. RESULTS: The feedback-training group showed a significantly higher hit rate after their training, whereas the test-experience group did not. The feedback training effects were manifested in weak line detection. CONCLUSIONS: This computer-based feedback training method can be an effective tool for improving RAT result readout skills.

    DOI: 10.1016/j.jiac.2023.10.019

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  • Complementary role of peripheral and central autonomic nervous system on insulin-like growth factor-1 activation to prevent fatty liver disease. International journal

    Itsuo Nagayama, Kenya Kamimura, Takashi Owaki, Masayoshi Ko, Takuro Nagoya, Yuto Tanaka, Marina Ohkoshi, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Shuji Terai

    Hepatology international   2023.10

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    BACKGROUND: Insulin-like growth factor-1 (IGF-1) is involved in the pathology of non-alcoholic fatty liver disease (NAFLD) and ameliorates fatty infiltration in the liver. It is activated by growth hormone (GH); however, the role of GH-IGF-1 axis in NAFLD developmental phase has not been well identified. Therefore, in this study, we focused on the effect of IGF-1 in NAFLD pathology and GH excretion activation from the pituitary gland by peripheral autonomic neural pathways relaying liver-brain-gut pathway and by central neuropeptides. METHODS: GH and IGF-1 levels were assessed in wild-type and melanocortin-4 receptor knockout mice upon the development of diet-induced NAFLD. The contribution of the peripheral autonomic nervous system connecting the liver-brain-gut axis was assessed by its blockade using capsaicin and that of the central nervous system was assessed by the expression of hypothalamic brain-derived neurotrophic factor (BDNF) and corticotropin-releasing factor (CRH), which activates GH release from the pituitary gland. RESULTS: In the NAFLD mouse models, the levels of GH and IGF-1 increased (p < .05). Further, hepatic fatty infiltration was suppressed even under peripheral autonomic nervous system blockade (p < .001), which inhibited gastric ghrelin expression. In mice with peripheral autonomic nervous blockade, hypothalamic BDNF and CRH were inhibited (p < .05), resulting in GH and IGF-1 excretion, whereas other neuropeptides of somatostatin and cortistatin showed no changes. These complementary effects were canceled in melanocortin-4 receptor knockout mice, which diminished BDNF and CRH release control. CONCLUSIONS: Our study demonstrates that the release of IGF-1 by the nervous system is a key factor in maintaining the pathological homeostasis of NAFLD, suggesting its therapeutic potential.

    DOI: 10.1007/s12072-023-10601-1

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  • Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis. International journal

    Nobutaka Takeda, Atsunori Tsuchiya, Masaki Mito, Kazuki Natsui, Yui Natusi, Yohei Koseki, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Hiroyuki Abe, Masayuki Sano, Taketomo Kido, Yusuke Yoshioka, Junichi Kikuta, Tohru Itoh, Ken Nishimura, Masaru Ishii, Takahiro Ochiya, Atsushi Miyajima, Shuji Terai

    Inflammation and regeneration   43 ( 1 )   48 - 48   2023.10

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    BACKGROUND: The progression of liver fibrosis leads to portal hypertension and liver dysfunction. However, no antifibrotic agents have been approved for cirrhosis to date, making them an unmet medical need. Small extracellular vesicles (sEVs) of mesenchymal stem cells (MSCs) are among these candidate agents. In this study, we investigated the effects of sEVs of MSCs, analyzed their distribution in the liver post-administration, whether their effect was dose-dependent, and whether it was possible to collect a large number of sEVs. METHODS: sEVs expressing tdTomato were generated, and their uptake into constituent liver cells was observed in vitro, as well as their sites of uptake and cells in the liver using a mouse model of liver cirrhosis. The efficiency of sEV collection using tangential flow filtration (TFF) and changes in the therapeutic effects of sEVs in a volume-dependent manner were examined. RESULTS: The sEVs of MSCs accumulated mostly in macrophages in damaged areas of the liver. In addition, the therapeutic effect of sEVs was not necessarily dose-dependent, and it reached a plateau when the dosage exceeded a certain level. Furthermore, although ultracentrifugation was commonly used to collect sEVs for research purposes, we verified that TFF could be used for efficient sEV collection and that their effectiveness is not reduced. CONCLUSION: In this study, we identified some unknown aspects regarding the dynamics, collection, and capacity dependence of sEVs. Our results provide important fundamentals for the development of therapies using sEVs and hold potential implications for the therapeutic applications of sEV-based therapies for liver cirrhosis.

    DOI: 10.1186/s41232-023-00299-x

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  • 機能性消化管疾患の病態解明と臨床応用 腸管運動機能に関わる組織常在型マクロファージを有する腸管オルガノイドの開発

    冨永 顕太郎, Wells James, 寺井 崇二

    Gastroenterological Endoscopy   65 ( Suppl.2 )   1809 - 1809   2023.10

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  • 重症急性膵炎後Walled-off necrosisの内視鏡治療における最適なステントの選択

    五十嵐 聡, 林 和直, 寺井 崇二

    Gastroenterological Endoscopy   65 ( Suppl.2 )   2046 - 2046   2023.10

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  • 高齢者の術後再建腸管結石例に対するダブルバルーン内視鏡下ERCPの検討

    林 和直, 五十嵐 聡, 寺井 崇二

    Gastroenterological Endoscopy   65 ( Suppl.2 )   2022 - 2022   2023.10

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  • 自律神経経路を基軸とする脂肪性肝疾患の脂質代謝制御機構の解明と治療薬探索

    上村 顕也, 大脇 崇史, 寺井 崇二

    日本消化器病学会雑誌   120 ( 臨増大会 )   A452 - A452   2023.10

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  • 脂肪性肝疾患の個別化医療に向けた提案 NAFLDの病態進展に関わるエフェクターを標的とした治療法の開発

    上村 顕也, 薛 徹, 寺井 崇二

    肝臓   64 ( Suppl.3 )   A743 - A743   2023.10

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  • Similarity of oncogenic protein expression in KRASG12D gene delivery-based rat pancreatic cancer model to that of human pancreatic cancer. International journal

    Yuto Tanaka, Kenya Kamimura, Osamu Shibata, Kohei Ogawa, Chiyumi Oda, Hiroyuki Abe, Satoshi Ikarashi, Kazunao Hayashi, Takeshi Yokoo, Toshifumi Wakai, Shuji Terai

    Biochemical and biophysical research communications   673   29 - 35   2023.9

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    BACKGROUND: The development of effective therapies and biomarkers for pancreatic cancer is an unmet clinical need. To address this, we have developed an easy-to-use pancreatic cancer rat animal model via pancreas-targeted hydrodynamic gene delivery of human pancreatic cancer-related genes. Our study aimed to determine the molecular similarity between the pancreatic tumor in the rat model and human pancreatic cancer. METHODS: KRASG12D gene-expressing plasmid was delivered to the pancreas of wild type rats via pancreas-targeted hydrodynamic gene delivery as previously reported. Tissue samples were collected at 5 weeks after the first gene delivery. The tumors developed in the rats were assessed for the expression of oncogenic proteins that are involved in human pancreatic cancer development. RESULTS: The development of a tumor mimicking pancreatic ductal adenocarcinoma was confirmed. The expression levels of Cyclin D1, c-Jun, IL-33, and Zip4 proteins in the tumor were immunohistochemically assessed and the correlation of the proteins was confirmed. The expression pattern showed similarity to that of surgically resected human pancreatic cancer tissues. CONCLUSIONS: Our study findings showing a similar pattern of oncogenic protein expression in novel KRASG12D gene-induced rat pancreatic cancer model and human pancreatic cancer will be useful for establishing novel tumor markers and therapeutic options for pancreatic cancer.

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  • Development and validation of machine learning model for predicting treatment responders in patients with primary biliary cholangitis. International journal

    Naruhiro Kimura, Kazuya Takahashi, Toru Setsu, Yusuke Horibata, Yusuke Kaneko, Haruka Miyazaki, Kohei Ogawa, Yuzo Kawata, Norihiro Sakai, Yusuke Watanabe, Hiroyuki Abe, Hiroteru Kamimura, Akira Sakamaki, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    Hepatology research : the official journal of the Japan Society of Hepatology   2023.9

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    AIMS: Ursodeoxycholic acid is the first-line treatment for primary biliary cholangitis, and treatment response is one of the factors predicting the outcome. To prescribe alternative therapies, clinicians might need additional information before deciphering the treatment response to ursodeoxycholic acid, contributing to a better patient prognosis. In this study, we developed and validated machine learning (ML) algorithms to predict treatment responses using pretreatment data. METHODS: This multicenter cohort study included collecting datasets from two data samples. Data 1 included 245 patients from 18 hospitals for ML development, and was divided into (i) training and (ii) development sets. Data 2 (iii: test set) included 51 patients from our hospital for validation. An extreme gradient boosted tree predicted the treatment response in the ML model. The area under the curve was used to evaluate the efficacy of the algorithm. RESULTS: Data 1 showed that patients complying with the Paris II treatment response had significantly lower serum alkaline phosphatase and total bilirubin levels than those who did not respond. Three factors, total bilirubin, total protein, and alanine aminotransferase levels were selected as essential variables for prediction. Data 2 showed that patients complying with the Paris II criteria had significantly high prothrombin time and low total bilirubin levels. The area under the curve of extreme gradient boosted tree was good for (ii) (0.811) and (iii) (0.856). CONCLUSIONS: We demonstrated the efficacy of ML in predicting the treatment response for patients with primary biliary cholangitis. Early identification of cases requiring additional treatment with our novel ML model may improve prognosis.

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  • 多職種の肝炎医療コーディネーターとの連携による,院内におけるC型肝炎患者の拾い上げと紹介率向上の効果

    荒生 祥尚, 酒井 規裕, 薛 徹, 渡邉 雄介, 木村 成宏, 阿部 寛幸, 坂牧 僚, 上村 博輝, 横尾 健, 土屋 淳紀, 上村 顕也, 寺井 崇二

    肝臓   64 ( Suppl.2 )   A634 - A634   2023.9

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  • 肝疾患に対する再生医療のNew normal New Normalへの提案 肝硬変に対する線維化改善を目指したトランスレーショナルリサーチ

    土屋 淳紀, 渡邉 雄介, 寺井 崇二

    肝臓   64 ( Suppl.2 )   A570 - A570   2023.9

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  • 【肝疾患とサルコペニア】総論 肝疾患とサルコペニア 未来のリハビリテーション医療 楽しくないと続かない

    寺井 崇二, 上村 博輝

    日本消化器病学会雑誌   120 ( 9 )   701 - 708   2023.9

  • 消化器病に対する低侵襲治療 切除不能肝内胆管癌に対して肝動脈化学塞栓療法(TACE)および重粒子線治療を行った1例

    内山 敦司, 上村 博輝, 木村 莉菓, 佐藤 千紘, 木村 究, 渡邉 雄介, 高橋 一也, 五十嵐 聡, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   39 ( 1 )   37 - 37   2023.9

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  • Repurposable Drugs for Immunotherapy and Strategies to Find Candidate Drugs. International journal

    Norihiro Sakai, Kenya Kamimura, Shuji Terai

    Pharmaceutics   15 ( 9 )   2023.8

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    Conventional drug discovery involves significant steps, time, and expenses; therefore, novel methods for drug discovery remain unmet, particularly for patients with intractable diseases. For this purpose, the drug repurposing method has been recently used to search for new therapeutic agents. Repurposed drugs are mostly previously approved drugs, which were carefully tested for their efficacy for other diseases and had their safety for the human body confirmed following careful pre-clinical trials, clinical trials, and post-marketing surveillance. Therefore, using these approved drugs for other diseases that cannot be treated using conventional therapeutic methods could save time and economic costs for testing their clinical applicability. In this review, we have summarized the methods for identifying repurposable drugs focusing on immunotherapy.

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  • 【ここまで進んだ肝硬変診療】肝硬変症の次世代治療の開発 抗線維化治療と肝再生療法

    寺井 崇二, 土屋 淳紀, 渡邊 雄介, 阿部 寛幸

    臨床消化器内科   38 ( 10 )   1329 - 1333   2023.8

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  • 【ここまで進んだ肝硬変診療】肝硬変症の次世代治療の開発 抗線維化治療と肝再生療法

    寺井 崇二, 土屋 淳紀, 渡邊 雄介, 阿部 寛幸

    臨床消化器内科   38 ( 10 )   1329 - 1333   2023.8

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  • Correction: Medaka as a model for human nonalcoholic steatohepatitis. International journal

    Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida

    Disease models & mechanisms   16 ( 7 )   2023.7

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  • 細胞および細胞外小胞で拓く創薬モダリティ 細胞外小胞を用いた肝硬変に対する線維化改善、修復療法の開発

    土屋 淳紀, 寺井 崇二

    日本DDS学会学術集会プログラム予稿集   39回   101 - 101   2023.7

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  • BCL11B expression in hepatocellular carcinoma relates to chemosensitivity and clinical prognosis. International journal

    Hiroyuki Abe, Kenya Kamimura, Shujiro Okuda, Yu Watanabe, Jun Inoue, Yutaka Aoyagi, Toshifumi Wakai, Ryo Kominami, Shuji Terai

    Cancer medicine   12 ( 14 )   15650 - 15663   2023.7

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    INTRODUCTION: B-cell lymphoma/leukemia 11B (BCL11B) is a subunit of SWI/SNF chromatin remodeling complexes and functions in cell cycle regulation and apoptosis upon DNA replication stress and damages via transcription. Many malignancies were reported to exhibit changes in BCL11B gene expression; however, no study has focused on the relationship between BCL11B and hepatocellular carcinoma, which potentially exhibits DNA replication stress and damages upon its oncogenesis. Thus, in this study, we examined the molecular characterization of BCL11B expression in hepatocellular carcinoma. METHODS AND RESULTS: The cumulative progression-free survival and overall survival were significantly longer in the clinical cases of BCL11B-negative hepatocellular carcinoma than BCL11B-positve cases. Microarray and real-time PCR analyses in hepatocellular carcinoma cell lines indicated a correlation between BCL11B and GATA6, a gene reported to be correlated with oncogenic activities and resistance to anthracycline, which is often used for hepatocellular carcinoma chemotherapy. Consequently, BCL11B-overexpressing cell lines exhibited resistance to anthracycline in cell growth assays and the resistance has been evidenced by the increased expression of BCL-xL in cell lines. The results were supported by the analyses of human HCC samples showing the correlation between BCL11B and GATA6 expressions. DISCUSSIONS AND CONCLUSION: Our results indicated that overexpression of BCL11B amplifies GATA6 expression in hepatocellular carcinoma in vitro and in vivo that leads to anti-apoptotic signal activation, and induces resistance to chemotherapy, which influenced the postoperative prognosis.

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  • Portal venous gas caused by barium swallow examination: An extremely rare clinical finding. International journal

    Takuya Wakabayashi, Kentaro Tominaga, Akira Sakamaki, Shuji Terai

    Clinical case reports   11 ( 7 )   e7480   2023.7

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    We found an extremely rare case of PVG after a barium swallow examination. This may be related to vulnerable intestinal mucosa in the patient undergoing prednisolone treatment. Conservative therapy should be considered for patients with PVG without bowel ischemia or perforation. Caution should be exercised during barium examination undergoing prednisolone treatment.

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  • 細胞および細胞外小胞で拓く創薬モダリティ 細胞外小胞を用いた肝硬変に対する線維化改善、修復療法の開発

    土屋 淳紀, 寺井 崇二

    日本DDS学会学術集会プログラム予稿集   39回   101 - 101   2023.7

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  • エンドトキシン吸着療法を行い救命し得た重症胆道感染症の2例

    齋藤 征爾, 坂田 純, 滝沢 一泰, 三浦 宏平, 石川 博補, 廣瀬 雄己, 安藤 拓也, 安部 舜, 宗岡 悠介, 田島 陽介, 市川 寛, 島田 能史, 阿部 寛幸, 小川 光平, 寺井 崇二, 若井 俊文

    新潟医学会雑誌   137 ( 7 )   243 - 248   2023.7

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  • エンドトキシン吸着療法を行い救命し得た重症胆道感染症の2例

    齋藤 征爾, 坂田 純, 滝沢 一泰, 三浦 宏平, 石川 博補, 廣瀬 雄己, 安藤 拓也, 安部 舜, 宗岡 悠介, 田島 陽介, 市川 寛, 島田 能史, 阿部 寛幸, 小川 光平, 寺井 崇二, 若井 俊文

    新潟医学会雑誌   137 ( 7 )   243 - 248   2023.7

  • Machine learning prediction model for treatment responders in patients with primary biliary cholangitis. International journal

    Naruhiro Kimura, Kazuya Takahashi, Toru Setsu, Shu Goto, Suguru Miida, Nobutaka Takeda, Yuichi Kojima, Yoshihisa Arao, Kazunao Hayashi, Norihiro Sakai, Yusuke Watanabe, Hiroyuki Abe, Hiroteru Kamimura, Akira Sakamaki, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   7 ( 6 )   431 - 438   2023.6

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    BACKGROUND AND AIM: Treatment response to ursodeoxycholic acid may predict the prognosis of patients with primary biliary cholangitis (PBC). Recent studies have suggested the benefits of using machine learning (ML) to forecast complex medical predictions. We aimed to predict treatment response in patients with PBC using ML and pretreatment data. METHODS: We conducted a single-center retrospective study and collected data from 194 patients with PBC who were followed up for at least 12 months after treatment initiation. Patient data were analyzed with five ML models, namely random forest, extreme gradient boosting (XGB), decision tree, naïve Bayes, or logistic regression, to predict treatment response using the Paris II criteria. The established models were assessed using an out-of-sample validation. The area under the curve (AUC) was used to evaluate the efficacy of each algorithm. Overall survival and liver-related deaths were analyzed using Kaplan-Meier analysis. RESULTS: Compared to logistic regression (AUC = 0.595, P = 0.0219, 0.031 models), ML analyses showed significantly high AUC in the random forest (AUC = 0.84) and XGB (AUC = 0.83) models; however, the AUC was not significantly high for decision tree (AUC = 0.633) or naïve Bayes (AUC = 0.584) models. Kaplan-Meier analysis showed significantly improved prognoses in patients predicted to achieve the Paris II criteria by XGB (log-rank = 0.005 and 0.007). CONCLUSION: ML algorithms could improve treatment response prediction using pretreatment data, which could lead to better prognoses. In addition, the ML model using XGB could predict the prognosis of patients before treatment initiation.

    DOI: 10.1002/jgh3.12915

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  • エクソソーム研究の最前線 間葉系幹細胞由来エクソソームによる肝硬変線維化改善を目指した研究開発

    阿部 寛幸, 武田 信峻, 水戸 將貴, 土屋 淳紀, 寺井 崇二

    The Journal of Toxicological Sciences   48 ( Suppl. )   S54 - S55   2023.6

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  • IgG4関連疾患における診断・治療困難例に対する取り組み 自己免疫性膵炎のステロイド治療導入後再燃例における臨床経過の検証

    小川 光平, 名古屋 拓郎, 五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   72回   40 - 40   2023.6

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  • 胆膵内視鏡検査・治療における工夫とトラブルシューティング 当院における副乳頭アプローチカニュレーション

    名古屋 拓郎, 小川 光平, 五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   72回   48 - 48   2023.6

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  • ヘパプラスチンテストを取り入れた出血原因鑑別の検査戦略 後天性第V因子欠乏症における経験

    松田 将門, 山田 隆, 古山 悠里, 柴崎 康彦, 関 義信, 星山 良樹, 寺井 崇二, 瀧澤 淳, 曽根 博仁, 増子 正義

    日本血栓止血学会誌   34 ( 2 )   262 - 262   2023.5

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  • 急性肝不全・ACLF診療の未来予想図(現状と課題) 肝線維化と老化細胞の出現から考えたAcute on chronic liver failureの病態解明

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    肝臓   64 ( Suppl.1 )   A78 - A78   2023.4

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  • FDA,PMDAデータベース20年の副作用報告から報告形態による国際比較の解析

    上村 博輝, 酒井 規裕, 木村 成宏, 薛 徹, 土屋 淳紀, 寺井 崇二

    肝臓   64 ( Suppl.1 )   A412 - A412   2023.4

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  • NASHメダカモデルにおける老化細胞除去剤としてのダサチニブ及びケルセチンの有用性に関する検証

    阿部 寛幸, 弥久保 俊太, 酒井 規裕, 木村 成宏, 坂牧 僚, 土屋 淳紀, 上村 顕也, 寺井 崇二

    肝臓   64 ( Suppl.1 )   A364 - A364   2023.4

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  • 急性腎障害を合併した消化器疾患における尿中NGAL測定による予後予測

    小島 雄一, 渡邉 雄介, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   120 ( 臨増総会 )   A393 - A393   2023.3

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  • 消化器疾患とビッグデータ インターネット普及による薬物関連有害事象報告の変遷 FDAの20年の副作用報告からの解析

    上村 博輝, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   120 ( 臨増総会 )   A40 - A40   2023.3

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  • 十全大補湯と間葉系幹細胞の併用療法は肝硬変・急性肝障害モデルマウスにおいて効果的な抗炎症・抗線維化効果を及ぼす

    野尻 俊介, 土屋 淳紀, 佐藤 毅昂, 熊谷 優, 茂木 聡子, 岩澤 貴宏, 小川 雅裕, 竹内 卓, 寺井 崇二

    肝臓   64 ( 3 )   172 - 172   2023.3

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  • 臨床応用を目指した消化器領域の再生医療研究 肝硬変のエクソソーム治療を目指した基礎的検討

    武田 信峻, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   120 ( 臨増総会 )   A166 - A166   2023.3

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  • 消化器診療とliquid biopsy 肝硬変の線維化の新たなエクソソームマーカー開発

    土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   120 ( 臨増総会 )   A159 - A159   2023.3

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  • 肝線維化研究の最前線と治療への展開 HMGB1部分ペプチドを用いた肝線維化改善検証と医師主導治験

    土屋 淳紀, 渡邉 雄介, 寺井 崇二

    日本消化器病学会雑誌   120 ( 臨増総会 )   A77 - A77   2023.3

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  • 膵癌早期診断の最前線 cStage 0/I膵癌の臨床像 膵癌病態解析に関する多施設後方視的観察研究の結果より

    五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会雑誌   120 ( 臨増総会 )   A135 - A135   2023.3

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  • 当院における膵小病変に対するEUS-FNA/Bの成績

    林 和直, 小川 光平, 五十嵐 聡, 寺井 崇二

    日本消化器病学会雑誌   120 ( 臨増総会 )   A375 - A375   2023.3

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  • 肥満モデルマウスを用いた、脂肪細胞の機能に着目した肥満制御メカニズムの解明

    坂牧 僚, 阿部 寛幸, 上村 顕也, 寺井 崇二

    新潟県医師会報   ( 876 )   12 - 13   2023.3

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  • 肝疾患における血中セロトニン値のバイオマーカーとしての有用性の検討

    薛 徹, 上村 顕也, 寺井 崇二

    肝臓   64 ( 3 )   171 - 171   2023.3

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  • Escherichia coli-derived outer-membrane vesicles induce immune activation and progression of cirrhosis in mice and humans. International journal

    Kazuki Natsui, Atsunori Tsuchiya, Risa Imamiya, Mayuko Osada-Oka, Yui Ishii, Yohei Koseki, Nobutaka Takeda, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Riuko Ohashi, Yiwei Ling, Koji Ueda, Nobuko Moritoki, Kazuhiro Sato, Takahiro Nakajima, Yoshinori Hasegawa, Shujiro Okuda, Shinsuke Shibata, Shuji Terai

    Liver international : official journal of the International Association for the Study of the Liver   43 ( 5 )   1126 - 1140   2023.2

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    BACKGROUND & AIMS: Decompensated cirrhosis with fibrosis progression causes portal hypertension followed by an oedematous intestinal tract. These conditions weaken the barrier function against bacteria in the intestinal tract, a condition called leaky gut, resulting in invasion by bacteria and bacterial components. Here, we investigated the role of outer membrane vesicles (OMVs) of Escherichia coli which is the representative pathogenic gut-derived bacteria in patients with cirrhosis in the pathogenesis of cirrhosis. METHODS: We investigated the involvement of OMVs in humans using human serum and ascites samples and also investigated the involvement of OMVs from Escherichia coli in mice using mouse liver-derived cells and a mouse cirrhosis model. RESULTS: In vitro, OMVs induced inflammatory responses to macrophages and neutrophils, including the upregulation of C-type lectin domain family 4 member E (Clec4e), and induced the suppression of albumin production in hepatocytes but had a relatively little direct effect on hepatic stellate cells. In a mouse cirrhosis model, administration of OMVs led to increased liver inflammation, especially affecting the activation of macrophages, worsening fibrosis, and decreasing albumin production. Albumin administration weakened these inflammatory changes. In addition, multiple antibodies against bacterial components were increased with a progressing Child-Pugh grade, and OMVs were detected in ascites of patients with decompensated cirrhosis. CONCLUSIONS: In conclusion, OMVs induce inflammation, fibrosis and suppression of albumin production, affecting the pathogenesis of cirrhosis. We believe that our study paves the way for the future prevention and treatment of cirrhosis.

    DOI: 10.1111/liv.15539

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  • Performance characteristics of 5 numerical indexes in mixing test interpretation under coexistence of lupus anticoagulant and coagulation factor deficiency. International journal

    Masato Matsuda, Yoshiki Hoshiyama, Kazuei Ogawa, Mari Emmi, Shuji Terai, Masato Moriyama

    Research and practice in thrombosis and haemostasis   7 ( 2 )   100065 - 100065   2023.2

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    BACKGROUND: The mixing test is useful to investigate the cause of unexpectedly prolonged activated partial thromboplastin time (APTT). Several indexes are available for distinguishing correction from non-correction (ie, factor deficiency from inhibitors), but their performance characteristics may differ because of their different formulas. Furthermore, it is unclear how each index performs under the coexistence of factor deficiency and inhibitors. OBJECTIVES: The objective of this study was to examine the differences in indexes, depending on factor VIII activity (FVIII:C) levels and lupus anticoagulant (LA) titers in test samples. METHODS: APTT was measured in spiked samples with various FVIII:C levels and LA titers, normal pooled plasma (NPP), and their 4:1, 1:1, and 1:4 mixtures. The following 5 indexes were calculated: index of circulating anticoagulant, mixing test normalized ratio, 4:1 and 1:1 percent corrections, and an APTT difference between the 1:1 mixture and NPP. The samples with LA, showing correction, were measured for FVIII:C in a one-stage assay to check parallelism. RESULTS: All indexes showed correction under FVIII deficiency and non-correction under higher LA titers. However, under lower LA titers, some indexes showed non-correction but others showed correction because of dilution effects and variations in formulas and/or sample mix ratios. The differences among the indexes were more pronounced under coexistent FVIII deficiency and LA, even though LA titers were equal in the tested samples; samples with lower FVIII:C showed correction, whereas those with normal FVIII:C showed non-correction. The samples tested for FVIII:C showed non-parallelism. CONCLUSION: Each index had different performance characteristics to LA samples, which were pronounced under low FVIII:C levels in test samples.

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  • 急性肝不全に対する治療 内科,外科の立場から 新潟県での急性肝不全診療ネットワークの構築とOn line HD導入への取り組み

    薛 徹, 上村 博輝, 坂牧 僚, 横尾 健, 上村 顕也, 土屋 淳紀, 高村 昌明, 寺井 崇二

    肝臓   64 ( 2 )   92 - 93   2023.2

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  • 【高齢者の消化器疾患-最新の診断と治療-】肝硬変・肝細胞癌

    坂牧 僚, 寺井 崇二

    日本臨床   81 ( 2 )   256 - 260   2023.2

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  • Analysis of Genetic Relatedness between Gastric and Oral Helicobacter pylori in Patients with Early Gastric Cancer Using Multilocus Sequence Typing

    Ryoko Nagata, Hiroki Sato, Shoji Takenaka, Junji Yokoyama, Shuji Terai, Hitomi Mimuro, Yuichiro Noiri

    International Journal of Molecular Sciences   24 ( 3 )   2211 - 2211   2023.1

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    The oral cavity is the second most colonized site of Helicobacter pylori after the stomach. This study aimed to compare the genetic relatedness between gastric and oral H. pylori in Japanese patients with early gastric cancer through multilocus sequence typing (MLST) analysis using eight housekeeping genes. Gastric biopsy specimens and oral samples were collected from 21 patients with a fecal antigen test positive for H. pylori. The number of H. pylori allelic profiles ranged from zero to eight since the yield of DNA was small even when the nested PCR was performed. MLST analysis revealed that only one patient had a matching oral and gastric H. pylori genotype, suggesting that different genotypes of H. pylori inhabit the oral cavity and gastric mucosa. The phylogenetic analysis showed that oral H. pylori in six patients was similar to gastric H. pylori, implying that the two strains are related but not of the same origin, and those strains may be infected on separate occasions. It is necessary to establish a culture method for oral H. pylori to elucidate whether the oral cavity acts as the source of gastric infection, as our analysis was based on a limited number of allele sequences.

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  • Analysis of drug-induced liver-related adverse event trend reporting between 1997 and 2019. International journal

    Hiroteru Kamimura, Toru Setsu, Naruhiro Kimura, Makoto Miyazawa, Shota Kaneko, Kenya Kamimura, Atsunori Tsuchiya, Yoshihiro Uesawa, Shuji Terai

    Hepatology research : the official journal of the Japan Society of Hepatology   53 ( 6 )   556 - 568   2023.1

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    AIM: This study aimed to analyze the current trends of drug-induced liver-related adverse events in the Food and Drug Administration Adverse Event Reporting System (FAERS) and Japanese Adverse Drug Event Report (JADER) databases. METHODS: The characteristics of implicated drugs were investigated by analyzing big data on drug-induced liver-related adverse events over the past 20 years in FAERS, comparing drug rankings between the JADER and FAERS databases, and calculating rankings of drugs inducing liver-related adverse events using the Medical Dictionary for Regulatory Activities Terminology. RESULTS: In the 452,272 cases registered in FAERS from 1997 to 2019, warfarin, paracetamol, and adalimumab were the drugs most related to DILI. In the 38,919 cases registered in the JADER from 2004 to 2019, sorafenib, nivolumab, and herbal extracts were the drugs most related to DILI. No associations were found between the top 30 drugs in either of the two databases. Notably, the number of drug-induced liver-related adverse event reports and total adverse events has sharply increased in recent years. CONCLUSIONS: Although liver-related adverse events are largely caused by host immunity and other constitutional factors, differences in primary diseases, countries, and historical backgrounds lead to differences in the number of reports. Securing an appropriate database and a mechanism to collect real-time information on the frequency of adverse drug reactions is warranted. This article is protected by copyright. All rights reserved.

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  • Navitoclax improves acute-on-chronic liver failure by eliminating senescent cells in mice. International journal

    Yusuke Watanabe, Hiroyuki Abe, Naruhiro Kimura, Yoshihisa Arao, Natsuki Ishikawa, Maeda Yuichiro, Toru Setsu, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    Hepatology research : the official journal of the Japan Society of Hepatology   53 ( 5 )   460 - 472   2023.1

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    AIM: Acute-on-chronic liver failure (ACLF), a disease with poor prognosis, is reportedly caused by cellular senescence due to mitochondrial dysfunction. In this study, we described and analyzed the underlying mechanism of a novel approach for ACLF using ABT263/navitoclax (Navi) that selectively eliminates senescent cells. METHODS: Irradiation-induced senescent hepatocytes were used for in vitro evaluation of the effects of Navi on ACLF (n = 6 for each group). Lipopolysaccharide- and carbon tetrachloride-induced ACLF mouse model was used for in vivo evaluation of the effects of Navi administration compared with the control using one-way or two-way analysis of variance, followed by Student's t-test or Kruskal-Wallis test. The effects on the senescence-associated secretory phenotype (n = 8 for each group) and mitochondrial functions, including adenosine triphosphate concentration and membrane potential (n = 8 for each group), were investigated using real-time polymerase chain reaction, immunohistochemistry, and enzyme analysis. RESULTS: Navi eliminated irradiation-induced senescent hepatocytes in vitro, leading to non-senescent hepatocyte proliferation. Navi eliminated senescent cells in the liver in vivo, resulting in downregulation of mRNA expression of senescence-associated secretory phenotype factors, a decrease of liver enzymes, and upregulated proliferation of non-senescent cells in the liver. Regarding mitochondrial functional assessment in the liver, adenosine triphosphate concentration and membrane potential were upregulated after Navi administration in vitro and in vivo. CONCLUSIONS: Navi may ameliorate ACLF damage by eliminating senescent cells in the liver, downregulating senescence-associated secretory phenotype factors, and upregulating mitochondrial functions. We believe that this novel approach using Navi will pave the way for ACLF treatment.

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  • Reducing relapse through maintenance steroid treatment can decrease the cancer risk in patients with IgG4-sclerosing cholangitis: Based on a Japanese nationwide study

    Kubota, K., Kamisawa, T., Nakazawa, T., Tanaka, A., Naitoh, I., Kurita, Y., Takikawa, H., Unno, M., Kawa, S., Masamune, A., Nakamura, S., Okazaki, K., Furumatsu, K., Sawai, S., Goto, T., Okumura, T., Suzuki, D., Otsuka, M., Kobori, I., Tamano, M., Koizumi, M., Hiasa, Y., Kawabe, N., Hirooka, Y., Yamamoto, S., Asano, Y., Inui, K., Horiguchi, A., Watanabe, H., Toya, D., Hatayama, K., Ueki, T., Kinoshita, N., Sugimoto, M., Ohira, H., Mukai, T., Tomita, E., Iwata, K., Shimizu, S., Suetsugu, J., Shimizu, M., Tsuji, K., Ishida, R., Ito, M., Furukawa, R., Sakamoto, N., Araki, M., Tanno, S., Sakamoto, Y., Ito, T., Takai, S., Ikeya, S., Yamada, T., Kudara, N., Shimizu, A., Hanada, K., Ichiki, Y., Kitada, H., Hifumi, M., Kimura, H., Kurosaki, M., Izumi, N., Sumi, H., Haruta, J.-I., Hayashi, K., Harada, R., Inoue, M., Nakamura, S., Ito, T., Tomishima, K., Isayama, H., Oura, K., Masaki, T., Shimokawahara, N., Tanoue, S., Maemura, K., Ido, A., Mizushima, I., Kawano, M., Yoshida, K., Naganuma, M., Murata, M., Nishio, A., Fujita, Y., Teratani, T., Matsubara, S., Tamai, H., Yoshida, Y., Azemoto, R., Kamata, K., Watanabe, T., Kurosu, T., Koizumi, W., Fujita, J., Seki, H., Ueda, Y., Fukumoto, T., Kousaki, T., Uchida, K., Ochiai, T., Kawasaki, T., Tanaka, M., Ishida, E., Notohara, K., Mori, H., Mori, T., Kawabata, H., Miyata, M., Sakagami, J., Itoh, Y., Shiokawa, M., Seno, H., Watanabe, N., Kataoka, H., Aoki, T., Fujishiro, M., Niihara, T., Nishimata, H., Mitoro, A., Yoshiji, H., Yoshida, M., Ikeda, M., Tomita, K., Hokari, R., Hayasaka, K., Amano, Y., Shioji, K., Hayashi, K., Terai, S., Nakajima, M., Yamahana, J., Matsumoto, R., Kikuchi, H., Kanamori, A., Kiriyama, S., Iwatsu, S., Kato, Y., Horiguchi, S., Yagi, T., Okada, H., Ohkawa, K., Hirao, M., Hiramatsu, N., Oza, N., Imamura, H., Baba, T., Nakano, S., Shinobi, T., Ryozawa, S., Motoya, M., Nakase, H., Kinoshita, N., Ito, K., Miyake, T., Kohge, N., Tobita, H., Joshita, S., Umemura, T., Kawaguchi, S., Ohno, K., Sonobe, K., Satoh, A., Shimosegawa, T., Miura, F., Yagi, M., Sano, K., Kin, T., Katanuma, A., Koike, K., Miura, S., Kawashima, Y., Kagawa, T., Azuma, S., Watanabe, M., Honjyo, M., Itoi, T., Honda, A., Kobayashi, K., Asano, T., Mizuno, S., Koike, K., Nishino, T., Taniguchi, H., Tajiri, K., Yasuda, I., Tanaka, Y., Oe, S., Harada, M., Kurata, M., Fukasawa, M., Enomoto, N., Kawaji, Y., Kitano, M., Nishise, Y., Hirakawa, H., Ishizawa, T., Ueno, Y., Kaino, M., Fujimoto, Y., Sakaida, I.

    Journal of Gastroenterology and Hepatology (Australia)   38 ( 4 )   2023

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    DOI: 10.1111/jgh.16066

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  • [Toward liver fibrosis amelioration and regenerative therapy using mesenchymal stem cells, extracellular vesicles, and peptides].

    Atsunori Tsuchiya, Shuji Terai

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   120 ( 12 )   973 - 979   2023

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    DOI: 10.11405/nisshoshi.120.973

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  • Basic points to consider regarding the preparation of extracellular vesicles and their clinical applications in Japan

    Tsuchiya, A., Terai, S., Horiguchi, I., Homma, Y., Saito, A., Nakamura, N., Sato, Y., Ochiya, T., Kino-oka, M.

    Regenerative Therapy   21   19 - 24   2022.12

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    DOI: 10.1016/j.reth.2022.05.003

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  • Edwardsiella tardaによる大量膿瘍をきたした肝硬変患者の1例 症例報告(Massive empyema with Edwardsiella tarda in a patient with liver cirrhosis: a case report)

    水戸 將貴, 木村 成宏, 山崎 華子, 神保 遼, 小島 雄一, 荒生 祥尚, 林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   71回・93回   47 - 47   2022.12

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  • HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. International journal

    Chiyumi Oda, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Yuto Tanaka, Toru Setsu, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Satoshi Kofuji, Toshifumi Wakai, Hiroshi Nishina, Shuji Terai

    Biochemistry and biophysics reports   32   101352 - 101352   2022.12

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    Background: Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) accounts for 10%-20% of the total HCC numbers. Its clinical features include the occurrence in the younger generation, large tumors, and poor prognosis. The contribution of hepatitis B virus X (HBx) protein in hepatocytes during activation of various oncogenic pathways has been reported. We aimed to assess the possible association between HBx and Yes-associated protein (YAP) expression in the liver tissue and the clinical features of HBV-related HCC. Methods: The relationship between HBx and YAP expression was examined in vivo using HCC tumor and peritumor tissues (n = 55). The clinical information including tumor size, marker, and the prognosis was assessed with protein expressions. The in vitro gene expression analyses were conducted using HBx- and YAP-overexpressing HCC cell lines. Results: Among 19 cases of HBV-related, 17 cases of hepatitis C virus (HCV)-related, and 19 cases of nonviral-related HCC, the HBV-related tumor showed the largest size. The HBx-stained area in the tumor and peritumor tissue showed a significant correlation with tumor size and serum α-fetoprotein level. YAP expression was higher in HBV-related tumor tissue than in the peritumor tissue and HCV-related tumor. Additionally, HBx and YAP protein expressions are correlated and both expressions in the tumor contributed to the poor prognosis. An in vitro study demonstrated that HBx and YAP overexpression in the hepatocytes activate the various oncogenic signaling pathways. Conclusions: Our study demonstrated that YAP expression in the liver of HBV-infected patients might be the key factor in HBV-related HCC development and control of tumor-related features.

    DOI: 10.1016/j.bbrep.2022.101352

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  • Gene panel testing detects important genetic alterations in ulcerative colitis-associated colorectal neoplasia. International journal

    Yoshifumi Shimada, Mae Nakano, Ken-Ichi Mizuno, Junji Yokoyama, Akio Matsumoto, Kana Tanaka, Hidehito Oyanagi, Masato Nakano, Yuki Hirose, Hiroshi Ichikawa, Jun Sakata, Hitoshi Kameyama, Yasumasa Takii, Mika Sugai, Yiwei Ling, Shiho Takeuchi, Shujiro Okuda, Shuji Terai, Yoichi Ajioka, Toshifumi Wakai

    Oncology letters   24 ( 6 )   442 - 442   2022.12

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    Ulcerative colitis-associated neoplasia (UCAN) harbors unique genetic alterations and mutational tendencies. The clinical application of gene panel testing enables precision medicine by tailoring treatment to individual gene alterations. We hypothesized that gene panel testing may detect clinically important genetic alterations in UCAN, with potential usefulness for the diagnosis and treatment of UCAN. In the present study, gene panel testing was used to identify genetic alterations in UCAN, and the possibility of clinical utility of gene panel testing in UCAN was investigated. The present study included 15 patients with UCAN, and gene panel testing was performed to identify genetic alterations associated with diagnosis and treatment. Genetic alterations of UCAN were compared with those of 203 patients with sporadic colorectal cancer (CRC). APC and PTEN mutations were less frequent, while RNF43 frameshift or nonsense mutations were more frequent in UCAN compared with sporadic CRC. TP53 mutations were identified in 13/15 patients (87%) with UCAN. Notably, 4/15 patients (27%) with UCAN had no genetic alterations other than TP53 mutation, while this occurred in 1/203 patients (0.5%) with sporadic CRC (P<0.001). Microsatellite instability-high was identified in 2/15 patients (13%) with UCAN. Mutational signature 3, which is associated with homologous recombination deficiency, was detected in 14/15 patients (93%) with UCAN, and enriched in UCAN compared with sporadic CRC (P=0.030). In conclusion, gene panel testing can detect important genetic alterations that can be useful for diagnosis and treatment in UCAN, and may provide clinicians with important information for tailored treatment strategies.

    DOI: 10.3892/ol.2022.13562

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  • 術後再建腸管例の悪性胆道狭窄に対するバルーン内視鏡下胆道ドレナージの有用性

    名古屋 拓郎, 寺井 崇二, 林 和直, 五十嵐 聡, 小川 光平

    ENDOSCOPIC FORUM for digestive disease   38 ( 2 )   153 - 153   2022.12

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  • 糖鎖欠損トランスフェリン値はγ-GTP値と相補的にアルコール性肝硬変の予後不良に関連する

    坂牧 僚, 小山 究太郎, 酒井 規裕, 阿部 寛幸, 上村 顕也, 寺井 崇二

    アルコールと医学生物学   41   71 - 73   2022.12

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  • Two rare pancreatic parenchymal hemorrhagic lesions associated with acute pancreatitis in acute liver failure: a case report and literature review.

    Ryo Jimbo, Yoshihisa Arao, Atsunori Tsuchiya, Hanako Yamazaki, Masaki Mito, Yuichi Kojima, Yuji Kobayashi, Naruhiro Kimura, Kazunao Hayashi, Shuji Terai

    Clinical journal of gastroenterology   2022.11

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    Acute pancreatitis is an uncommon occurrence in acute liver failure. Furthermore, such cases are rarely complicated by parenchymal hemorrhages. Herein, we report the case of a 69-year-old male patient with multiple pancreatic parenchymal hemorrhages concomitant with acute liver failure. The patient underwent conservative treatment for acute liver failure caused by hepatitis B virus infection. Plain computed tomography on the 30th day revealed two high-density mass lesions in the pancreatic body and tail, which were suspected to be multiple pancreatic parenchymal hemorrhages. Despite restarting gabexate mesylate, the patient died of multiple organ failure on the 49th day. The clinical information of the present case and our literature review of 61 similar cases in 43 case reports identified via a systematic keyword search of the PubMed database, which described acute pancreatitis concomitant with acute hepatitis and acute liver failure, will aid physicians in the diagnosis and treatment of this rare condition.

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  • Cell-free and concentrated ascites reinfusion therapy versus large-volume paracentesis for the treatment of cirrhotic patients with refractory ascites: A multicenter prospective observational study. International journal

    Tatsunori Hanai, Hideto Kawaratani, Junji Nagano, Hirokazu Suii, Akira Sakamaki, Yoshitaka Arase, Hiroyuki Nakanishi, Tomomi Kogiso, Tomomi Okubo, Takao Miwa, Shogo Shimizu, Shuhei Hige, Masanori Atsukawa, Masahito Shimizu, Masayuki Kurosaki, Shuji Terai, Tatehiro Kagawa, Katsutoshi Tokushige, Hitoshi Yoshiji

    Hepatology research : the official journal of the Japan Society of Hepatology   53 ( 3 )   238 - 246   2022.11

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    AIM: Cell-free and concentrated ascites reinfusion therapy (CART) and large-volume paracentesis (LVP) with albumin infusion are useful for managing refractory ascites (RA). However, it remains unclear which therapy is more effective in patients with cirrhosis with RA. METHODS: From June 2018 to March 2022, 25 patients with RA treated with CART or LVP with albumin infusion were enrolled in this multicenter prospective observational study to investigate the number of abdominal paracenteses, albumin preparations used, and drainage volume during an 8-week observation period. RESULTS: Among all patients at entry (median age, 63 years; 52% men; 60% Child-Pugh B and 40% Child-Pugh C), 92% were treated with furosemide (median, 20 mg/day), 92% with spironolactone (25 mg/day), and all with tolvaptan (7.5 mg/day). Patients with RA had a poor health-related quality of life (HRQOL) and prominent ascites-related symptoms. Four of the 20 eligible patients were treated with CART, 11 with LVP with albumin infusion, and five with their combination. The median number of paracenteses, total drainage volume, and albumin infusions were 1.5, 7.4 L, and 0, respectively, in the CART group; 5.0, 22.0 L, and 5.0, respectively, in the LVP group; and 5.0, 30.0 L, and 5.0, respectively in their combination group. The treatment effects did not differ significantly among the three groups regarding weight loss, liver function, renal function, electrolytes, and HRQOL. However, patients treated with CART had fewer paracenteses and albumin infusions than those treated with LVP. CONCLUSIONS: CART and LVP have comparable therapeutic efficacy for RA in patients with cirrhosis.

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  • Weakly Supervised Multiple Instance Learning for Liver Cirrhosis Classification using Ultrasound Images

    Yusuke Fujita, Kaito Ishihara, Kazuma Nakata, Yoshihiko Hamamoto, Makoto Segawa, Isao Sakaida, Yoshihiro Mitani, Shuji Terai

    2022 7th International Conference on Intelligent Informatics and Biomedical Science (ICIIBMS)   2022.11

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    DOI: 10.1109/iciibms55689.2022.9971604

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  • Early‐phase prothrombin time‐international normalized ratio in acute liver injury indicates the timing of therapeutic intervention and predicts prognostic improvement

    Kotaro Kumagai, Seiichi Mawatari, Akihiro Moriuchi, Kohei Oda, Yasuhiro Takikawa, Naoya Kato, Shigeto Oda, Kazuaki Inoue, Shuji Terai, Takuya Genda, Masahito Shimizu, Isao Sakaida, Satoshi Mochida, Akio Ido

    Hepatology Research   53 ( 2 )   160 - 171   2022.11

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    DOI: 10.1111/hepr.13848

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  • 【再生医療の現状と展望】間葉系幹細胞を用いた肝疾患の再生医療

    土屋 淳紀, 寺井 崇二

    BIO Clinica   37 ( 12 )   1089 - 1093   2022.11

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  • 小児NAFLD患者の背景疾患と移行医療への課題

    上村 博輝, 佐藤 毅昂, 山崎 文紗子, 坂牧 僚, 土屋 淳紀, 寺井 崇二, 長崎 啓祐, 齋藤 昭彦

    肥満研究   28 ( Suppl. )   290 - 290   2022.11

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  • 小児NAFLD患者の背景疾患と移行医療への課題

    上村 博輝, 佐藤 毅昂, 山崎 文紗子, 坂牧 僚, 土屋 淳紀, 寺井 崇二, 長崎 啓祐, 齋藤 昭彦

    肥満研究   28 ( Suppl. )   290 - 290   2022.11

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  • Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression.

    Norihiro Sakai, Kenya Kamimura, Hirotaka Miyamoto, Masayoshi Ko, Takuro Nagoya, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Hiroyuki Soki, Ayako Tokunaga, Tatsuo Inamine, Mikiro Nakashima, Hatsune Enomoto, Kazuki Kousaka, Hidehisa Tachiki, Kaname Ohyama, Shuji Terai

    Journal of gastroenterology   58 ( 1 )   53 - 68   2022.10

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    BACKGROUND: To establish a treatment option for liver fibrosis, the possibility of the drug repurposing theory was investigated, with a focus on the off-target effects of active pharmaceutical ingredients. METHODS: First, several active pharmaceutical ingredients were screened for their effects on the gene expression in the hepatocytes using chimeric mice with humanized hepatocytes. As per the gene expression-based screening assay for 36 medications, we assessed the mechanism of the antifibrotic effect of letrozole, a third-generation aromatase inhibitor, in mouse models of liver fibrosis induced by carbon tetrachloride (CCl4) and a methionine choline-deficient (MCD) diet. We assessed liver histology, serum biochemical markers, and fibrosis-related gene and protein expressions in the hepatocytes. RESULTS: A gene expression-based screening assay revealed that letrozole had a modifying effect on fibrosis-related gene expression in the hepatocytes, including YAP, CTGF, TGF-β, and CYP26A1. Letrozole was administered to mouse models of CCl4- and MCD-induced liver fibrosis and it ameliorated the liver fibrosis. The mechanisms involved the inhibition of the Yap-Ctgf profibrotic pathway following a decrease in retinoic acid levels in the hepatocytes caused by suppression of the hepatic retinol dehydrogenase, Hsd17b13 and activation of the retinoic acid hydrogenase, Cyp26a1. CONCLUSIONS: Letrozole slowed the progression of liver fibrosis by inhibiting the Yap-Ctgf pathway. The mechanisms involved the modification of the Hsd17b13 and Cyp26a1 expressions led to the suppression of retinoic acid in the hepatocytes, which contributed to the activation of Yap-Ctgf pathway. Because of its off-target effect, letrozole could be repurposed for the treatment of liver fibrosis. The third-generation aromatase inhibitor letrozole ameliorated liver fibrosis by suppressing the Yap-Ctgf pathway by partially modifying the Hsd17b13 and Cyp26a1 expressions, which reduced the retinoic acid level in the hepatocytes. The gene expression analysis using chimeric mice with humanized liver revealed that the mechanisms are letrozole specific and, therefore, may be repurposed for the treatment of liver fibrosis.

    DOI: 10.1007/s00535-022-01929-w

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  • 肝再生・移植医療への新規トランスレーショナルリサーチ 肝硬変に対するHMGB1部分ペプチドを用いた基礎研究から医師主導治験実施へ

    土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.3 )   A710 - A710   2022.10

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  • 肝硬変,肝癌治療薬の薬物関連有害事象報告の国際比較把握とその解釈による今後のマネージメント

    上村 博輝, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.3 )   A792 - A792   2022.10

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  • 機械学習を用いた上部内視鏡施行時の咽頭老化の予測

    上村 博輝, 小島 雄一, 高橋 一也, 高綱 将史, 平野 正明, 政二 文明, 水野 研一, 横山 純二, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増大会 )   A812 - A812   2022.10

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  • 門脈圧亢進症に対する診断・治療における新たな挑戦 機械学習を用いた慢性心不全に続発した肝臓への障害(Cardiac Hepatopathy)の画像解析

    三井田 秀, 上村 博輝, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増大会 )   A640 - A640   2022.10

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  • ガイドライン改訂後の膵炎診療の現状と課題 重症急性膵炎後Walled-off necrosisの経過における抗菌薬投与の影響

    五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増大会 )   A534 - A534   2022.10

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  • 重症急性膵炎後Walled-off necrosisの内視鏡治療におけるLumen apposing metal stentの有効性

    林 和直, 五十嵐 聡, 小川 光平, 寺井 崇二

    Gastroenterological Endoscopy   64 ( Suppl.2 )   2126 - 2126   2022.10

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  • Acute-on-chronic liver failure(ACLF):わが国の現状と今後の課題 ACLFの新規治療開発に向けた基盤研究

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.2 )   A508 - A508   2022.9

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  • 慢性肝疾患におけるTGFβ3の発現と肝予備能との関連性についての検討

    阿部 寛幸, 酒井 規裕, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 上村 博輝, 坂牧 僚, 横尾 健, 上村 顕也, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.2 )   A597 - A597   2022.9

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  • 大腸菌の外膜小胞は肝硬変での更なる炎症・線維化増悪に寄与する

    夏井 一輝, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.2 )   A593 - A593   2022.9

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  • アテゾリズマブ+ベバシズマブ併用療法の非奏効例におけるLate line移行時期についての検討

    横尾 健, 酒井 規裕, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 阿部 寛幸, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.2 )   A582 - A582   2022.9

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  • 慢性肝疾患におけるTGFβ3の発現と肝予備能との関連性についての検討

    阿部 寛幸, 酒井 規裕, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 上村 博輝, 坂牧 僚, 横尾 健, 上村 顕也, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.2 )   A597 - A597   2022.9

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  • ウイルス駆除時代における,院内非専門医での効果的なC型肝炎患者の拾い上げ

    荒生 祥尚, 酒井 規裕, 寺井 崇二

    肝臓   63 ( Suppl.2 )   A557 - A557   2022.9

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  • アテゾリズマブ+ベバシズマブ併用療法の非奏効例におけるLate line移行時期についての検討

    横尾 健, 酒井 規裕, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 阿部 寛幸, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.2 )   A582 - A582   2022.9

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  • Synthesized HMGB1 peptide prevents the progression of inflammation, steatosis, fibrosis, and tumor occurrence in a non-alcoholic steatohepatitis mouse model. International journal

    Yui Ishii, Atsunori Tsuchiya, Kazuki Natsui, Youhei Koseki, Nobutaka Takeda, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Takashi Shimbo, Katsuto Tamai, Shuji Terai

    Hepatology research : the official journal of the Japan Society of Hepatology   2022.8

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    AIM: Non-alcoholic steatohepatitis (NASH) with fibrosis eventually leads to cirrhosis and hepatocellular carcinoma. Thus, the development of therapies other than dietary restriction and exercise, particularly those that suppress steatosis and fibrosis of the liver and have a long-term beneficial effect, is necessary. We aimed to evaluate the therapeutic effects of the HMGB1 peptide synthesized from box A using the melanocortin-4 receptor-deficient (Mc4r-KO) NASH model mouse. METHODS: We performed short- and long-term administration of this peptide and evaluated the effects on steatosis, fibrosis, and carcinogenesis using Mc4r-KO mice. We also analyzed the direct effect of this peptide on macrophages and hepatic stellate cells in vitro and performed lipidomics and metabolomics techniques to evaluate the effect. RESULTS: Although this peptide did not show direct effects on macrophages and hepatic stellate cells in vitro, in the short-term administration model, we could confirm the reduction of liver damage, steatosis, and fibrosis progression. The results of lipidomics and metabolomics suggested that the peptide might ameliorate NASH by promoting lipolysis via the activation of fatty acid β-oxidation and improving insulin resistance. In the long-term administration model, this peptide prevented progression to cirrhosis but retained the steatosis state, that is, the peptide prevents the progression to "burnt-out NASH." This peptide inhibited carcinogenesis by about one-third. CONCLUSION: This HMGB1 peptide can reduce liver damage, improve fibrosis and steatosis, and inhibit carcinogenesis, suggesting that the peptide would be a new treatment candidate for NASH and can contribute to the long-term prognosis for patients with NASH.

    DOI: 10.1111/hepr.13825

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  • Effects of a selective PPARα modulator, sodium-glucose cotransporter 2 inhibitor, and statin on the myocardial morphology of medaka nonalcoholic fatty liver disease model. International journal

    Marina Ohkoshi-Yamada, Kenya Kamimura, Atsushi Kimura, Yuto Tanaka, Itsuo Nagayama, Shunta Yakubo, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Shuji Terai

    Biochemical and biophysical research communications   625   116 - 121   2022.8

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    OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic dysregulation and is linked with various cardiovascular complications, which often lead to poor prognostic outcomes. To develop a standard therapy for NAFLD and to urgently address its complications, the current study aimed to investigate the mechanisms of NAFLD-related heart disease and the therapeutic effects of drugs targeting various metabolic pathways. METHODS: To explore the mechanism of NAFLD-related heart disease, a medaka model of high-fat diet-induced NAFLD was utilized. The gross structural, histological, and inflammatory changes in the myocardium were evaluated in a time-dependent manner. In addition, the therapeutic effects of medicines used for NAFLD treatment including, selective peroxisome proliferator-activated receptor α modulator (SPPARMα, pemafibrate), sodium-glucose cotransporter 2 (SGLT2) inhibitor (tofogliflozin), and statin (pitavastatin), and their combinations on heart pathology were evaluated. To determine the mechanisms underlying the therapeutic effects, the expression of genes related to liver inflammation was assessed via whole transcriptome sequencing analysis. RESULTS: The fish with NAFLD-related heart injury presented with cardiomyocyte hypertrophy, which led to cardiac hypertrophy. This morphological change was caused by the infiltration of inflammatory cells, including macrophages and CD4- and CD8-positive lymphocytes, in the cardiac wall and the expression of transforming growth factor beta 1 in the cardiomyocytes. Further, the livers of the fish had upregulated expressions of senescence-associated secretory phenotype-related genes. Treatment with pemafibrate, tofogliflozin, and pitavastatin reduced these changes and, consequently, cardiomyopathy. CONCLUSION: Our results demonstrated that NAFLD-related heart disease was attributed to the senescence-associated secretory phenotype-induced inflammatory activity in the cardiac wall, which resulted in myocardial hypertrophy. Moreover, the effects of SPPARMα, SGLT2 inhibitor, and statin on NAFLD-related heart disease were evident in the medaka NAFLD model.

    DOI: 10.1016/j.bbrc.2022.07.117

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  • 機械学習を用いた慢性心不全に続発した肝臓への障害(Cardiac Hepatopathy)の画像解析

    三井田 秀, 上村 博輝, 山崎 文紗子, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 薛 徹, 横尾 健, 坂牧 僚, 土屋 淳紀, 藤木 伸也, 猪又 孝元, 寺井 崇二

    日本門脈圧亢進症学会雑誌   28 ( 3 )   152 - 152   2022.8

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  • Cumulative risk of developing a new symptom in patients with primary biliary cholangitis and its impact on prognosis. International journal

    Naruhiro Kimura, Toru Setsu, Yoshihisa Arao, Norihiro Sakai, Yusuke Watanabe, Hiroyuki Abe, Hiroteru Kamimura, Akira Sakamaki, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Akihiko Osaki, Kentarou Igarashi, Nobuo Waguri, Masahiko Yanagi, Toru Takahashi, Soichi Sugitani, Yuka Kobayashi, Masaaki Takamura, Akira Yoshikawa, Toru Ishikawa, Toshiaki Yoshida, Toshiaki Watanabe, Hitoshi Bannai, Tomoyuki Kubota, Kazuhiro Funakoshi, Hiroto Wakabayashi, So Kurita, Norio Ogata, Masashi Watanabe, Yuhsaku Mita, Shigeki Mori, Motoya Sugiyama, Toru Miyajima, Sumio Takahashi, Shuichi Sato, Kisei Ishizuka, Hironobu Ohta, Yutaka Aoyagi, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   6 ( 8 )   577 - 586   2022.8

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    Background and Aim: Symptoms of primary biliary cholangitis (PBC) frequently impair one's quality of life (QOL). Nonetheless, with improved treatment, the prognosis of PBC also improves. QOL plays an important role in patients with PBC. In this study, we aimed to reevaluate the transition of new symptom development in PBC and its predictive factors. Methods: This retrospective multicenter study enrolled 382 patients with PBC for symptom analysis. The impact of a newly developed symptom on PBC prognosis was investigated by Kaplan-Meier analysis with propensity score matching and logistic progression analysis. Results: The cumulative risk of developing a new symptom after 10 and 20 years of follow-up was 7.6 and 28.2%, and specifically that of pruritus, which was the most common symptom, was 6.7 and 23.3%, respectively. In Cox hazard risk analysis, serum Alb level (hazard ratio [HR], 1.097; 95% confidence interval [CI], 1.033-1.165; P = 0.002), the serum D-Bil level (HR, 6.262; 95% CI, 2.522-15.553, P < 0.001), and Paris II criteria (HR, 0.435; 95% CI, 0.183-1.036; P = 0.037) were significant independent predictors of a new symptom. Kaplan-Meier analysis showed that the overall survival and liver-related death were not significant between patients with and without a new symptom. Conclusion: The cumulative risk of new symptom development is roughly 30% 20 years after diagnosis and could be predicted by factors including serum albumin levels, serum D-Bil level, and Paris II criteria.

    DOI: 10.1002/jgh3.12789

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  • 機械学習を用いた慢性心不全に続発した肝臓への障害(Cardiac Hepatopathy)の画像解析

    三井田 秀, 上村 博輝, 山崎 文紗子, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 薛 徹, 横尾 健, 坂牧 僚, 土屋 淳紀, 藤木 伸也, 猪又 孝元, 寺井 崇二

    日本門脈圧亢進症学会雑誌   28 ( 3 )   152 - 152   2022.8

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  • アルコール関連臓器障害における細胞間・臓器間ネットワークの新展開 肝疾患における自律神経経路を介した臓器連関の関与

    上村 顕也, 永山 逸夫, 大脇 崇史, 高 昌良, 名古屋 拓郎, 井上 良介, 坂牧 僚, 寺井 崇二

    日本アルコール・薬物医学会雑誌   57 ( 4 )   121 - 121   2022.8

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  • Allograft liver failure awaiting liver transplantation in Japan.

    Takuya Genda, Takafumi Ichida, Eiji Tanaka, Satoshi Mochida, Yoshiyuki Ueno, Shuji Terai, Ayano Inui, Yoshihide Ueda, Hideki Ohdan, Hiroto Egawa, Koji Umeshita, Hiroyuki Furukawa, Yukihiro Inomata

    Journal of gastroenterology   57 ( 7 )   495 - 504   2022.7

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    BACKGROUND: Following liver transplantation (LT), allograft liver failure can be developed by various causes and requires re-LT. Hence, this study aimed to clarify the characteristics and prognostic factors of patients with allograft liver failure awaiting deceased donor LT (DDLT) in Japan. METHODS: Of the 2686 DDLT candidates in Japan between 2007 and 2016, 192 adult patients listed for re-LT were retrospectively enrolled in this study. Factors associated with waitlist mortality were assessed using the Cox proportional hazards model. The transplant-free survival probabilities were evaluated using the Kaplan-Meier analysis and log-rank test. RESULTS: The median period from the previous LT to listing for re-LT was 1548 days (range, 4-8449 days). Primary sclerosing cholangitis (PSC), which was a primary indication, showed a higher listing probability for re-LT as compared with other primary etiologies. Recurrent liver disease was a leading cause of allograft failure and was more frequently observed in the primary indication of hepatitis C virus (HCV) infection and PSC in contrast with other etiologies. Multivariate analysis identified the following independent risk factors associated with waitlist mortality: age, Child-Turcotte-Pugh (CTP) score, mode for end-stage liver disease (MELD) score, alanine aminotransferase (ALT), and causes of allograft failure. CONCLUSIONS: Recurrent HCV and PSC were major causes of allograft liver failure in Japan. In addition to CTP and MELD scores, either serum ALT levels or causes of allograft failure should be considered as graft liver allocation measures.

    DOI: 10.1007/s00535-022-01880-w

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  • (II章)肝 肝硬変に対する再生医療

    寺井 崇二, 土屋 淳紀

    消化器内科学レビュー   2022-'23   213 - 216   2022.7

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  • 肝性腹水が腹部コンパートメント症候群を介して腎機能へ与える影響の検討

    上村 博輝, 酒井 規裕, 小島 雄一, 川田 雄三, 渡邊 雄介, 荒生 祥尚, 木村 成宏, 阿部 寛幸, 薛 徹, 横尾 健, 坂牧 僚, 土屋 淳紀, 上村 顕也, 横山 純二, 寺井 崇二

    日本門脈圧亢進症学会雑誌   28 ( 2 )   199 - 203   2022.7

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  • 『高齢者(75歳以上)の非アルコール性脂肪性肝疾患の現状と課題』非アルコール性脂肪性肝炎を背景とした高齢者肝硬変に対する非侵襲的スコアリングシステムの有用性の検討

    坂牧 僚, 酒井 規裕, 阿部 寛幸, 横尾 健, 上村 顕也, 寺井 崇二

    日本高齢消化器病学会誌   25 ( 1 )   74 - 74   2022.7

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  • 【肝性脳症の病態と治療】肝性脳症と腸内細菌 病態と治療

    坂牧 僚, 上村 顕也, 横山 邦彦, 酒井 規裕, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 薛 徹, 阿部 寛幸, 上村 博輝, 横尾 健, 土屋 淳紀, 寺井 崇二

    消化器・肝臓内科   12 ( 1 )   68 - 72   2022.7

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  • 各都道府県における肝疾患対策取り組みの現状 新潟県の肝炎対策について

    荒生 祥尚, 薛 徹, 酒井 規裕, 寺井 崇二

    肝臓クリニカルアップデート   8 ( 1 )   82 - 85   2022.7

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  • 肝性腹水が腹部コンパートメント症候群を介して腎機能へ与える影響の検討

    上村 博輝, 酒井 規裕, 小島 雄一, 川田 雄三, 渡邊 雄介, 荒生 祥尚, 木村 成宏, 阿部 寛幸, 薛 徹, 横尾 健, 坂牧 僚, 土屋 淳紀, 上村 顕也, 横山 純二, 寺井 崇二

    日本門脈圧亢進症学会雑誌   28 ( 2 )   199 - 203   2022.7

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  • The liver-gut peripheral neural axis and nonalcoholic fatty liver disease pathologies via hepatic serotonin receptor 2A. International journal

    Takashi Owaki, Kenya Kamimura, Masayoshi Ko, Itsuo Nagayama, Takuro Nagoya, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Takeki Sato, Toru Setsu, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Shuji Terai

    Disease models & mechanisms   15 ( 7 )   2022.6

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    Serotonin (5-HT) is one of the key bioamines of nonalcoholic fatty liver disease (NAFLD). Its mechanism via autonomic neural signal pathways remains unexplained; hence, we evaluated the involvement of 5-HT and related-signaling pathways via autonomic nerves in NAFLD. Diet-induced NAFLD animal models were developed using wild-type and melanocortin 4 receptor knockout (MC4RKO) mice, and the effects of autonomic neural axis on NAFLD physiology, 5-HT and its receptors (Htrs), and lipid metabolism-related genes were assessed applying hepatic nerve blockade. Hepatic neural blockade retarded the progression of NAFLD by reducing 5-HT in the small intestine, hepatic Htr2a, and hepatic lipogenic genes expression, and HTR2A antagonist reproduced these effects. The effects were milder in MC4RKO, and brain 5-HT and Htr2c expression did not correlate with peripheral neural blockade. Our study demonstrates that the autonomic liver-gut neural axis is involved in the etiology of diet-induced NAFLD and that 5-HT and HTR2A are key factors, implying that the modulation of the axis and use of HTR2A antagonists are potentially novel therapeutic strategies for NAFLD treatment.

    DOI: 10.1242/dmm.049612

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  • Involvement of DNA Damage Response via the Ccndbp1-Atm-Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced Colitis. International journal

    Ryoko Horigome, Kenya Kamimura, Yusuke Niwa, Kohei Ogawa, Ken-Ichi Mizuno, Koichi Fujisawa, Naoki Yamamoto, Taro Takami, Tomoyuki Sugano, Akira Sakamaki, Hiroteru Kamimura, Masaaki Takamura, Shuji Terai

    Journal of clinical medicine   11 ( 13 )   2022.6

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    The dextran sodium sulfate (DSS)-induced colitis mouse model has been widely utilized for human colitis research. While its mechanism involves a response to double-strand deoxyribonucleic acid (DNA) damage, ataxia telangiectasia mutated (Atm)-checkpoint kinase 2 (Chk2) pathway activation related to such response remains unreported. Recently, we reported that cyclin D1-binding protein 1 (Ccndbp1) activates the pathway reflecting DNA damage in its knockout mice. Thus, this study aimed to examine the contribution of Ccndbp1 and the Atm-Chk2 pathway in DSS-induced colitis. We assessed the effect of DSS-induced colitis on colon length, disease activity index, and histological score and on the Atm-Chk2 pathway and the subsequent apoptosis in Ccndbp1-knockout mice. DSS-induced colitis showed distal colon-dominant Atm and Chk2 phosphorylation, increase in TdT-mediated dUTP-biotin nick end labeling and cleaved caspase 3-positive cells, and histological score increase, causing disease activity index elevation and colon length shortening. These changes were significantly ameliorated in Ccndbp1-knockout mice. In conclusion, Ccndbp1 contributed to Atm-Chk2 pathway activation in the DSS-induced colitis mouse model, causing inflammation and apoptosis of mucosal cells in the colon.

    DOI: 10.3390/jcm11133674

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  • Daisaikoto improves fatty liver and obesity in melanocortin-4 receptor gene-deficient mice via the activation of brown adipose tissue. International journal

    Shinichi Morita, Akira Sakamaki, Kyutaro Koyama, Osamu Shibata, Takashi Owaki, Chiyumi Oda, Atsushi Kimura, Taiki Nakaya, Katsuya Ohbuchi, Miwa Nahata, Naoki Fujitsuka, Norihiro Sakai, Hiroyuki Abe, Kenya Kamimura, Shuji Terai

    Scientific reports   12 ( 1 )   10105 - 10105   2022.6

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    Melanocortin 4 receptor gene-knockout (MC4R-KO) mice are known to develop obesity with a high-fat diet. Meanwhile, daisaikoto, one of Kampo medicines, is a drug that is expected to have therapeutic effects on obesity. Here, we report the efficacy of daisaikoto in MC4R-KO mice. Eight-week-old MC4R-KO male mice (n = 12) were divided into three groups as follows: the SD group, which is fed with a standard diet; the HFD group, fed a high-fat diet; and the DSK group, fed with a high-fat diet containing 10% of daisaikoto. After the four-week observation period, mice in each group were sacrificed and samples were collected. The body weights at 12 weeks were significantly higher in the HFD group than in the other groups, indicating that daisaikoto significantly reduced body weight gain and fat deposition of the liver. The metabolome analysis indicated that degradation of triglycerides and fatty acid oxidation in the liver were enhanced by daisaikoto administration. In MC4R-KO mice, the cytoplasm and uncoupling protein 1 expression of brown adipose tissue was decreased; however, it was reversed in the DSK group. In conclusion, daisaikoto has potentially improved fatty liver and obesity, making it a useful therapeutic agent for obesity and fatty liver.

    DOI: 10.1038/s41598-022-14371-y

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  • Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method. International journal

    Osamu Shibata, Kenya Kamimura, Yuto Tanaka, Kohei Ogawa, Takashi Owaki, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Hiroyuki Abe, Satoshi Ikarashi, Kazunao Hayashi, Takeshi Yokoo, Shuji Terai

    Molecular therapy. Nucleic acids   28   342 - 352   2022.6

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    This research developed an easy-to-use, reproducible pancreatic cancer animal model utilizing pancreas-targeted hydrodynamic gene delivery to deliver human pancreatic cancer-related genes to the pancreas of wild-type rats. KRAS G12D -induced pancreatic intraepithelial neoplasia lesions showed malignant transformation in the main pancreatic duct at 4 weeks and developed acinar-to-ductal metaplasia, which led to pancreatic ductal adenocarcinoma within 5 weeks, and the gene combination of KRAS G12D and YAP enhanced these effects. The repeat hydrodynamic gene delivery of KRAS G12D  + YAP combination at 4 weeks showed acinar-to-ductal metaplasia in all rats and pancreatic ductal adenocarcinoma in 80% of rats 1 week later. Metastatic tumors in the liver, lymph nodes, and subcutaneous lesions and nervous invasion were confirmed. KRAS G12D and YAP combined transfer contributes to the E- to N-cadherin switch in pancreatic ductal adenocarcinoma cells and to tumor metastases. This pancreatic cancer model will speed up pancreatic cancer research for novel treatments and biomarkers for early diagnosis.

    DOI: 10.1016/j.omtn.2022.03.019

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  • 多発性出血性膵炎を伴う重度の急性肝不全の一例(A case of severe acute liver failure with multiple hemorrhagic pancreatitis)

    神保 遼, 荒生 祥尚, 山崎 華子, 水戸 將貴, 小島 雄一, 木村 成宏, 小林 雄司, 林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   70回   np41 - np41   2022.6

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  • 【肝臓と他臓器相関】脂肪性肝疾患における自律神経系を介した消化管ホルモンの関与

    大脇 崇史, 上村 顕也, 永山 逸夫, 高 昌良, 名古屋 拓郎, 井上 良介, 薛 徹, 寺井 崇二

    消化器・肝臓内科   11 ( 6 )   709 - 713   2022.6

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  • 多発性出血性膵炎を伴う重度の急性肝不全の一例(A case of severe acute liver failure with multiple hemorrhagic pancreatitis)

    神保 遼, 荒生 祥尚, 山崎 華子, 水戸 將貴, 小島 雄一, 木村 成宏, 小林 雄司, 林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   70回   np41 - np41   2022.6

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  • 悪性胆道狭窄に対する治療戦略 術後再建腸管例の悪性胆道狭窄に対するバルーン内視鏡下胆道ドレナージの有用性

    名古屋 拓郎, 寺井 崇二, 林 和直, 五十嵐 聡, 小川 光平

    日本消化器病学会甲信越支部例会抄録集   70回   np46 - np46   2022.6

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  • NAFLDにおける肝-脳-腸関連と自律神経の関係

    永山 逸夫, 上村 顕也, 高 昌良, 大脇 崇史, 名古屋 拓郎, 寺井 崇二

    自律神経   59 ( 2 )   208 - 211   2022.6

  • Diagnostic criteria for acute-on-chronic liver failure and related disease conditions in Japan. International journal

    Satoshi Mochida, Nobuaki Nakayama, Shuji Terai, Hitoshi Yoshiji, Masahito Shimizu, Akio Ido, Kazuaki Inoue, Takuya Genda, Yasuhiro Takikawa, Taro Takami, Naoya Kato, Masanori Abe, Ryuzo Abe, Ayano Inui, Hiromasa Ohira, Mureo Kasahara, Kazuaki Chayama, Kiyoshi Hasegawa, Atsushi Tanaka

    Hepatology research : the official journal of the Japan Society of Hepatology   52 ( 5 )   417 - 421   2022.5

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    The Intractable Hepato-Biliary Disease Study Group of Japan, sponsored by the Ministry of Health, Labor and Wealth, proposed in 2018 that patients with cirrhosis and a Child-Pugh score of 5-9 should be diagnosed as having acute-on-chronic liver failure (ACLF) when a deterioration of liver function ("serum bilirubin level of 5.0 mg/dl or more" and "prothrombin time value of 40% or less of the standardized values and/or international normalization rates of 1.5 or more") caused by severe liver damage develops within 28 days after an acute insult, including alcohol abuse, bacterial infection, gastrointestinal bleeding, and the exacerbation of underlying liver diseases. Disease severity can be classified into 4 grades depending on the extent of the deterioration in organ functions, including liver, kidney, cerebral, blood coagulation, circulatory and respiratory functions. The Study Group has since performed an annual nationwide survey of patients with ACLF diagnosed according to the proposed diagnostic criteria as well as those with disease conditions related to ACLF. A total of 501 patients, including 183 patients diagnosed as having ACLF, seen between 2017 and 2019 were enrolled, and univariate and multivariate analyses revealed that the proposed diagnostic criteria were useful for identifying cirrhotic patients with an unfavorable outcome following an acute insult. Consequently, the Study Group determined that the proposed diagnostic criteria should be used in both clinical practice and clinical research as formal diagnostic criteria.

    DOI: 10.1111/hepr.13763

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  • Development of Dilated Esophagus, Sigmoid Esophagus, and Esophageal Diverticulum in Patients With Achalasia: Japan Achalasia Multicenter Study. International journal

    Hiroki Sato, Yusuke Fujiyoshi, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shuji Terai, Haruhiro Inoue

    Journal of neurogastroenterology and motility   28 ( 2 )   222 - 230   2022.4

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    Background/Aims: Patients with achalasia-related esophageal motility disorders (AEMDs) frequently present with dilated and sigmoid esophagus, and develop esophageal diverticulum (ED), although the prevalence and patients characteristics require further elucidation. Methods: We conducted a multicenter cohort study of 3707 patients with AEMDs from 14 facilities in Japan. Esophagography on 3682 patients were analyzed. Results: Straight (n = 2798), sigmoid (n = 684), and advanced sigmoid esophagus (n = 200) were diagnosed. Multivariate analysis revealed that long disease duration, advanced age, obesity, and type I achalasia correlate positively, whereas severe symptoms and integrated relaxation pressure correlate negatively with development of sigmoid esophagus. In contrast, Grade II dilation (3.5-6.0 cm) was the most common (52.9%), while grade III dilation (≥ 6 cm) was rare (5.0%). We found early onset, male, obesity, and type I achalasia correlated positively, while advanced age correlated negatively with esophageal dilation. Dilated and sigmoid esophagus were found mostly in types I and II achalasia, but typically not found in spastic disorders. The prevalence of ED was low (n = 63, 1.7%), and non-dilated esophagus and advanced age correlated with ED development. Patients with right-sided ED (n = 35) had a long disease duration (P = 0.005) with low integrated relaxation pressure values (P = 0.008) compared with patients with left-sided ED (n = 22). Patients with multiple EDs (n = 6) had lower symptom severity than patients with a single ED (P = 0.022). Conclusions: The etiologies of dilated esophagus, sigmoid esophagus, and ED are considered multifactorial and different. Early diagnosis and optimal treatment of AEMDs are necessary to prevent these conditions.

    DOI: 10.5056/jnm21188

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  • Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature.

    Natsuki Ishikawa, Kenya Kamimura, Saori Endo, Soichi Ishii, Kazuya Ogawa, Norihiro Sakai, Hiroyuki Abe, Masayoshi Ko, Osamu Shibata, Youhei Koseki, Junji Yokoyama, Akira Sakamaki, Shuji Terai

    Internal medicine (Tokyo, Japan)   2022.4

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    Regarding the prognosis of cases with advanced-stage hepatocellular carcinoma (HCC), a recent clinical study showed that the immune checkpoint inhibitors atezolizumab plus bevacizumab have superior efficacy to sorafenib. However, only a few reports have focused on their effects on extrahepatic metastases. We herein report a case of HCC in a 59-year-old man with intrahepatic lesions treated successfully by hepatic arterial chemoembolization, radiotherapy, and sorafenib; the extrahepatic lesion in the adrenal gland was treated by atezolizumab plus bevacizumab. The patient showed a tumor-free condition for one year. We have summarized the clinical course and reviewed the literature to underscore the efficacy of atezolizumab plus bevacizumab for treating extrahepatic lesions of HCC.

    DOI: 10.2169/internalmedicine.9341-22

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  • 老化細胞除去治療のAcute on chronic liverfailureに対する効果の検証

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A371 - A371   2022.4

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  • 肝硬変-合併症の管理(含む門脈圧亢進症) 水素型の小腸内細菌異常増殖は肝疾患の不顕性肝性脳症と筋肉量低下に関連する

    坂牧 僚, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A64 - A64   2022.4

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  • 【革新的技術が変える肝疾患診療】間葉系幹細胞・エクソソームを用いた肝硬変治療

    土屋 淳紀, 寺井 崇二

    消化器・肝臓内科   11 ( 4 )   494 - 499   2022.4

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  • Relative Dose Intensityに基づく高齢者レンバチニブ投与における全生存期間の検討

    横尾 健, 酒井 規裕, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 阿部 寛幸, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A302 - A302   2022.4

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  • Utility of autologous fecal microbiota transplantation and elucidation of microbiota in diversion colitis. International journal

    Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yoshida, Yuichi Kojima, Kohei Ogawa, Yuzo Kawata, Nao Nakajima, Naruhiro Kimura, Hiroyuki Abe, Toru Setsu, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Junji Yokoyama, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Toshifumi Wakai, Shuji Terai

    DEN open   2 ( 1 )   e63   2022.4

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    Objectives: Diversion colitis (DC) is an inflammatory disorder caused by interruption of the fecal stream and subsequent nutrient deficiency from luminal bacteria. The utility of fecal microbiota transplantation (FMT) for DC was recently investigated; however, the precise pathogenesis of this condition remains unclear. This study aimed to evaluate the utility of autologous FMT in DC and to determine the related changes in the intestinal microbiota. Methods: Autologous FMT was performed to reestablish the intestinal microbiota in five patients (average age, 64.6 ± 8.3 years) with DC. They underwent double-ended colostomy. We assessed the diverted colon by endoscopy and evaluated the microbiota before and after FMT using the 16S rRNA gene sequencing method. Results: All five patients had mild inflammation (ulcerative colitis endoscopic index of severity [UCEIS] 2-3) in the diverted colon based on the colonoscopic findings. Three patients presented with symptoms, such as tenesmus, mucoid stool, and bloody stool. With FMT treatment, all patients achieved endoscopic remission (UCEIS score of 0 or 1) and symptomatic improvement. We observed a significantly decreased α-diversity in DC patients compared to healthy controls. The frequency of aerobic bacteria, such as Enterobacteriaceae, in the diverted colon decreased after autologous FMT. Conclusions: This study was the first to show that the microbiota in the diverted colon was significantly affected by autologous FMT. Since interruption of the fecal stream is central to the development of DC, FMT can be considered a promising treatment.

    DOI: 10.1002/deo2.63

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  • Intestinal duplication diagnosed preoperatively with double-balloon enteroscopy: an extremely rare case report and literature review.

    Yusuke Niwa, Kentaro Tominaga, Yuzo Kawata, Takamasa Kobayashi, Takeshi Mizuwasa, Kazuya Takahashi, Hiroki Sato, Junji Kohisa, Satoshi Abe, Kenya Kamimura, Junji Yokoyama, Hirokazu Kawai, Hideaki Sugino, Hajime Umezu, Yumiko Hirai, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Toshifumi Wakai, Shuji Terai

    Clinical journal of gastroenterology   15 ( 2 )   381 - 387   2022.4

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    Gastrointestinal duplications are congenital malformations that are usually observed in pediatric patients. Diagnosis in adulthood is quite rare, and preoperative diagnosis of gastrointestinal duplication is difficult, particularly in the small intestine. We encountered an extremely rare adult case of duplication of the jejunum, which showed a stomach-like form diagnosed using double-balloon enteroscopy (DBE). The patient was an 18-year-old male who had been experiencing upper abdominal pain and vomiting repeatedly without any triggers for 3 years. Various examinations were performed, but no cause of symptoms was found. DBE revealed a narrow opening of the lumen at the upper jejunum, and the lumen was covered with mucosal folds similar to those of the stomach. Enteroclysis via DBE showed a tubular structure on the mesenteric side of the jejunum. We diagnosed a jejunal tubular duplication with ectopic gastric mucosa and underwent partial small bowel resection. The patient's abdominal symptoms resolved. From this, DBE can be a useful tool for diagnosing intestinal duplication in adults. We believe that this case and literature review will facilitate the accurate and prompt diagnosis of small intestinal duplication.

    DOI: 10.1007/s12328-022-01596-7

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  • Methotrexate-associated proliferative disorder in the lower esophagus extending to the gastroesophageal junction: A case report. International journal

    Yuki Hojo, Masafumi Takatsuna, Satoshi Ikarashi, Hiroteru Kamimura, Rika Kimura, Masaki Mito, Yusuke Watanabe, Yusuke Tani, Junji Yokoyama, Shuji Terai

    DEN open   2 ( 1 )   e14   2022.4

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    A 64-year-old woman was receiving oral methotrexate (MTX) for rheumatoid arthritis (RA) for 15 years. She underwent esophagogastroduodenoscopy because of discomfort in the chest. Endoscopic findings revealed an ulcer in the lower esophagus extending to the gastroesophageal junction (EGJ). The ulcer occupied half of the esophageal lumen and had a sharp and clear margin. Magnifying narrow-band imaging endoscopy revealed the deposition of white plaque, and there were few microvessels in the edge and bottom of the ulcer. Histologic examination of the biopsy specimens from the oral edge of the lesion revealed proliferation of atypical lymphoid cells (immunophenotype results: CD20 [+], CD3 [partially +], CD5 [-], and BCL-2 [-]]. The patient was diagnosed with methotrexate-associated lymphoproliferative disorder (MTX-LPD) and was advised to stop MTX intake. After 2 months of stopping MTX, the ulcer was found to be almost regressed and showed signs of healing. MTX-LPD in the lower esophagus extending to the EGJ is extremely rare. This case can help in expanding the understanding of esophageal MTX-LPD.

    DOI: 10.1002/deo2.14

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  • 肝線維化研究Revisited-肝臓学のBiologyからTranslationalへ ヒト肝細胞キメラマウスを用いた薬剤のスクリーニング ドラッグリポジショニングによる肝線維化治療薬の探索・メカニズムの検証

    酒井 規裕, 上村 顕也, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A174 - A174   2022.4

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  • 脂肪性肝疾患における自律神経系経路を介した脂質代謝制御の解明と治療薬スクリーニング

    上村 顕也, 大脇 崇史, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A254 - A254   2022.4

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  • Relative Dose Intensityに基づく高齢者レンバチニブ投与における全生存期間の検討

    横尾 健, 酒井 規裕, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 阿部 寛幸, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A302 - A302   2022.4

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  • 肝疾患の小児・成人移行期医療の課題-全人的ケアの確立を目指して 成人外来へ受診する可能性をもつ小児脂肪肝の特徴

    上村 博輝, 上村 顕也, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A169 - A169   2022.4

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  • 医療機関連携急性肝不全ネットワークを円滑に行い生体肝移植にて救命できた急性肝不全昏睡型の1例

    武田 信峻, 土屋 淳紀, 石井 結唯, 夏井 一輝, 荒生 祥尚, 冨永 顕太郎, 林 和直, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A265 - A265   2022.4

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  • 本県での肝炎医療コーディネーター養成の現状と活動事例紹介

    酒井 規裕, 薛 徹, 荒生 祥尚, 澤栗 裕美, 廣川 光, 星田 和哉, 是永 匡紹, 寺井 崇二, 新たな手法を用いた肝炎ウイルス検査受検率・陽性者受診率の向上に資する研究班

    肝臓   63 ( Suppl.1 )   A243 - A243   2022.4

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  • FALD(フォンタン術後肝障害)の疫学・病態・臨床-診療ガイドラインの確立を目指して 先天性心疾患術後の肝線維化進展に影響を及ぼす因子の解析

    山崎 文紗子, 上村 博輝, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A192 - A192   2022.4

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  • 【1ページでわかる内科疾患の診療ノート-"あたりまえ"のなかにある大事な視点】(第7章)肝・胆・膵 非代償性肝硬変

    上村 博輝, 寺井 崇二

    内科   129 ( 4 )   867 - 871   2022.4

  • 肝疾患の小児・成人移行期医療の課題-全人的ケアの確立を目指して 成人外来へ受診する可能性をもつ小児脂肪肝の特徴

    上村 博輝, 上村 顕也, 寺井 崇二

    肝臓   63 ( Suppl.1 )   A169 - A169   2022.4

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  • Effects of a novel selective PPARα modulator, statin, sodium-glucose cotransporter 2 inhibitor, and combinatorial therapy on the liver and vasculature of medaka nonalcoholic steatohepatitis model. International journal

    Atsushi Kimura, Kenya Kamimura, Marina Ohkoshi-Yamada, Yoko Shinagawa-Kobayashi, Ryo Goto, Takashi Owaki, Chiyumi Oda, Osamu Shibata, Shinichi Morita, Norihiro Sakai, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Shuji Terai

    Biochemical and biophysical research communications   596   76 - 82   2022.3

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    OBJECTIVE: Nonalcoholic steatohepatitis (NASH) is a disease entity with an increasing incidence, with involvement of several metabolic pathways. Various organs, including the liver, kidneys, and the vasculature, are damaged in NASH, indicating the urgent need to develop a standard therapy. Therefore, this study was conducted to investigate the effects of drugs targeting various metabolic pathways and their combinations on a high-fat diet (HFD)-induced NASH medaka model. METHODS: To investigate the effects of drugs on vascular structures, the NASH animal model was developed using the fli::GFP transgenic medaka fed with HFD at 20 mg/fish daily. The physiological changes, histological changes in the liver, vascular structures in the fin, and serum biochemical markers were evaluated in a time-dependent manner after treatment with selective peroxisome proliferator-activated receptor α modulator (pemafibrate), statin (pitavastatin), sodium-glucose cotransporter 2 inhibitor (tofogliflozin), and their combinations. Furthermore, to determine the mechanisms underlying the effects, whole transcriptome sequencing was conducted using medaka liver samples. RESULTS: Histological analyses revealed significant suppression of fat accumulation and fibrotic changes in the liver after treatment with drugs and their combinations. The expression levels of steatosis- and fibrosis-related genes were modified by the treatments. Moreover, the HFD-induced vascular damages in the fin exhibited milder changes after treatment with the drugs. CONCLUSION: The effects of treating various metabolic pathways on the medaka body, liver, and vascular structures of the NASH medaka model were evidenced. Moreover, to our knowledge, this study is the first to report whole genome sequence and gene expression evaluation of medaka livers, which could be helpful in clarifying the molecular mechanisms of drugs.

    DOI: 10.1016/j.bbrc.2022.01.086

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  • Long-Term Efficacy and Safety of Rifaximin in Japanese Patients with Hepatic Encephalopathy: A Multicenter Retrospective Study. International journal

    Hideto Kawaratani, Yasuteru Kondo, Ryoji Tatsumi, Naoto Kawabe, Norikazu Tanabe, Akira Sakamaki, Kazuo Okumoto, Yoshihito Uchida, Kei Endo, Takumi Kawaguchi, Tsunekazu Oikawa, Yoji Ishizu, Shuhei Hige, Taro Takami, Shuji Terai, Yoshiyuki Ueno, Satoshi Mochida, Yasuhiro Takikawa, Takuji Torimura, Tomokazu Matsuura, Masatoshi Ishigami, Kazuhiko Koike, Hitoshi Yoshiji

    Journal of clinical medicine   11 ( 6 )   2022.3

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    BACKGROUND: Rifaximin is commonly used for hepatic encephalopathy (HE). However, the effects of long-term treatment for Japanese people are limited. Therefore, this study aimed to investigate the effects and safety of long-term treatment with rifaximin on HE. METHODS: A total of 215 patients with cirrhosis administered with rifaximin developed overt or covert HE, which was diagnosed by an attending physician for &gt;12 months. Laboratory data were extracted at pretreatment and 3, 6, and 12 months after rifaximin administration. The long-term effect of rifaximin was evaluated, and the incidence of overt HE during 12 months and adverse events was extracted. RESULTS: Ammonia levels were significantly improved after 3 months of rifaximin administration and were continued until 12 months. There were no serious adverse events after rifaximin administration. The number of overt HE incidents was 9, 14, and 27 patients within 3, 6, and 12 months, respectively. Liver enzymes, renal function, and electrolytes did not change after rifaximin administration. Prothrombin activity is a significant risk factor for the occurrence of overt HE. The serum albumin, prothrombin activity, and albumin-bilirubin (ALBI) scores were statistically improved after 3 and 6 months of rifaximin administration. Moreover, the same results were obtained in patients with Child-Pugh C. CONCLUSIONS: The long-term rifaximin treatment was effective and safe for patients with HE, including Child-Pugh C.

    DOI: 10.3390/jcm11061571

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  • 消化器疾患に対する分化・老化・再生研究の展開 Acute on chronic liver failureに対する老化細胞除去治療の新規開発のための基盤研究

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A32 - A32   2022.3

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  • 肝疾患の画像情報による病態解明と診療応用 心不全患者が肝形態に及ぼす影響(Cardiac Hepatopathy)の画像による解析

    上村 博輝, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A223 - A223   2022.3

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  • 消化器疾患診療に必要なバイオマーカー開発のための研究 エクソソームタンパクEps8の膵癌バイオマーカーとしての検討

    林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A172 - A172   2022.3

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  • 脂肪肝炎:今後の展開 自律神経経路が制御する多臓器連関の解析と脂肪肝炎制御への展開

    上村 顕也, 大脇 崇史, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A60 - A60   2022.3

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  • 肝線維化研究の進展と臨床応用 肝線維化関連遺伝子発現変化にもとづく抗線維化作用を有するリパーパシングドラッグの探索

    酒井 規裕, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A138 - A138   2022.3

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  • 老化と消化器がんの病態・診療 Relative Dose Intensityに注目した高齢者レンバチニブ治療の安全性と有効性

    横尾 健, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A186 - A186   2022.3

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  • 肝移植適応疾患の病態解明と診療展開 肝障害に伴う臓器連関による血中セロトニン濃度変化と病態の検討 肝不全の病態変化を推測するマーカーの樹立へ

    薛 徹, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A219 - A219   2022.3

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  • 脂肪肝炎:今後の展開 自律神経経路が制御する多臓器連関の解析と脂肪肝炎制御への展開

    上村 顕也, 大脇 崇史, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A60 - A60   2022.3

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  • 肝移植適応疾患の病態解明と診療展開 肝障害に伴う臓器連関による血中セロトニン濃度変化と病態の検討 肝不全の病態変化を推測するマーカーの樹立へ

    薛 徹, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A219 - A219   2022.3

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  • 老化と消化器がんの病態・診療 Relative Dose Intensityに注目した高齢者レンバチニブ治療の安全性と有効性

    横尾 健, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A186 - A186   2022.3

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  • 肝線維化研究の進展と臨床応用 肝線維化関連遺伝子発現変化にもとづく抗線維化作用を有するリパーパシングドラッグの探索

    酒井 規裕, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A138 - A138   2022.3

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  • 病態に基づく肝疾患医療連携の今後 肝炎医療コーディネーターと連携した院内における肝炎ウイルス陽性者の拾い上げ

    荒生 祥尚, 薛 徹, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A229 - A229   2022.3

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  • 重症急性膵炎後Walled-off necrosisの経過に対する抗菌薬投与の影響

    五十嵐 聡, 林 和直, 寺井 崇二, 小川 光平

    日本消化器病学会雑誌   119 ( 臨増総会 )   A344 - A344   2022.3

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  • 栄養・代謝機能と消化器疾患の病態解明と治療 膵臓癌における脂肪酸分画の臨床的意義についての検証

    小川 光平, 林 和直, 寺井 崇二

    日本消化器病学会雑誌   119 ( 臨増総会 )   A174 - A174   2022.3

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  • Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM-CHK2 Pathway. International journal

    Yusuke Niwa, Kenya Kamimura, Kohei Ogawa, Chiyumi Oda, Yuto Tanaka, Ryoko Horigome, Masato Ohtsuka, Hiromi Miura, Koichi Fujisawa, Naoki Yamamoto, Taro Takami, Shujiro Okuda, Masayoshi Ko, Takashi Owaki, Atsushi Kimura, Osamu Shibata, Shinichi Morita, Norihiro Sakai, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Shuji Terai

    Journal of clinical medicine   11 ( 3 )   2022.2

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    Cyclin D1 binding protein 1 (CCNDBP1) is considered a tumor suppressor, and when expressed in tumor cells, CCNDBP1 can contribute to the viability of cancer cells by rescuing these cells from chemotherapy-induced DNA damage. Therefore, this study focused on investigating the function of CCNDBP1, which is directly related to the survival of cancer cells by escaping DNA damage and chemoresistance. Hepatocellular carcinoma (HCC) cells and tissues obtained from Ccndbp1 knockout mice were used for the in vitro and in vivo examination of the molecular mechanisms of CCNDBP1 associated with the recovery of cells from DNA damage. Subsequently, gene and protein expression changes associated with the upregulation, downregulation, and irradiation of CCNDBP1 were assessed. The overexpression of CCNDBP1 in HCC cells stimulated cell growth and showed resistance to X-ray-induced DNA damage. Gene expression analysis of CCNDBP1-overexpressed cells and Ccndbp1 knockout mice revealed that Ccndbp1 activated the Atm-Chk2 pathway through the inhibition of Ezh2 expression, accounting for resistance to DNA damage. Our study demonstrated that by inhibiting EZH2, CCNDBP1 contributed to the activation of the ATM-CHK2 pathway to alleviate DNA damage, leading to chemoresistance.

    DOI: 10.3390/jcm11030851

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  • A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice. International journal

    Satoko Motegi, Atsunori Tsuchiya, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Kazuki Natsui, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yosiki Sakai, Shigeru Miyagawa, Yoshiki Sawa, Shuji Terai

    Inflammation and regeneration   42 ( 1 )   3 - 3   2022.2

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    BACKGROUND: ONO-1301 is a novel long-lasting prostaglandin (PG) I2 mimetic with inhibitory activity on thromboxane (TX) A2 synthase. This drug can also induce endogenous prostaglandin (PG)I2 and PGE2 levels. Furthermore, ONO-1301 acts as a cytokine inducer and can initiate tissue repair in a variety of diseases, such as pulmonary hypertension, pulmonary fibrosis, cardiac infarction, and obstructive nephropathy. In this study, our aim was to evaluate the effect of ONO-1301 on liver inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH). METHODS: The therapeutic effects of ONO-1301 against liver damage, fibrosis, and occurrence of liver tumors were evaluated using melanocortin 4 receptor-deficient (Mc4r-KO) NASH model mice. The effects of ONO-1301 against macrophages, hepatic stellate cells, and endothelial cells were also evaluated in vitro. RESULTS: ONO-1301 ameliorated liver damage and fibrosis progression, was effective regardless of NASH status, and suppressed the occurrence of liver tumors in Mc4r-KO NASH model mice. In the in vitro study, ONO-1301 suppressed LPS-induced inflammatory responses in cultured macrophages, suppressed hepatic stellate cell (HSC) activation, upregulated vascular endothelial growth factor (VEGF) expression in HSCs, and upregulated hepatocyte growth factor (HGF) and VEGF expression in endothelial cells. CONCLUSIONS: The results of our study highlight the potential of ONO-1301 to reverse the progression and prevent the occurrence of liver tumors in NASH using in vivo and in vitro models. ONO-1301 is a multidirectional drug that can play a key role in various pathways and can be further analyzed for use as a new drug candidate against NASH.

    DOI: 10.1186/s41232-021-00191-6

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  • Simultaneous muscular hemorrhages in two regions three years after successfully controlling refractory ascites using transjugular intrahepatic portosystemic shunt treatment: a case report.

    Hiroteru Kamimura, Michitaka Imai, Hiroyuki Abe, Aiko Yoshioka, Kanae Hirose, Noriko Ishihara, Toru Ishikawa, Shuji Terai

    Clinical journal of gastroenterology   2022.1

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    INTRODUCTION: Various therapies and drugs have been developed to extend the life expectancy of patients with liver cirrhosis. The prolonged prognosis of cirrhotic patients may change the final cause of death in the future. Deep bleeding into the muscle is an uncommon but potentially life-threatening complication of liver cirrhosis. CASE REPORT: A 53-year-old man had undergone transjugular intrahepatic portosystemic shunt treatment for refractory ascites, which successfully controlled it for three years. However, he had started drinking again and experienced acute-on-chronic liver failure. He also had severe back pain. Abdominal computed tomography showed hyperdensities in the retroperitoneum and right pleural cavity. Despite blood infusion, he died from acute-on-chronic liver failure. A pathological autopsy revealed bleeding from the iliopsoas and right diaphragmatic muscle simultaneously, evident from the presence of red blood cells located between the muscle sheaths. Disruption of the small vessels in the skeletal muscle fibers was inferred. CONCLUSION: This is a critical case that underscores the significance of improving available knowledge based on the cause of final death of the patients with cirrhosis, who now have a good long-term prognosis owing to the latest medical developments.

    DOI: 10.1007/s12328-022-01591-y

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  • Use of a Deep Learning Approach for the Sensitive Prediction of Hepatitis B Surface Antigen Levels in Inactive Carrier Patients. International journal

    Hiroteru Kamimura, Hirofumi Nonaka, Masaya Mori, Taichi Kobayashi, Toru Setsu, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    Journal of clinical medicine   11 ( 2 )   2022.1

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    Deep learning is a subset of machine learning that can be employed to accurately predict biological transitions. Eliminating hepatitis B surface antigens (HBsAgs) is the final therapeutic endpoint for chronic hepatitis B. Reliable predictors of the disappearance or reduction in HBsAg levels have not been established. Accurate predictions are vital to successful treatment, and corresponding efforts are ongoing worldwide. Therefore, this study aimed to identify an optimal deep learning model to predict the changes in HBsAg levels in daily clinical practice for inactive carrier patients. We identified patients whose HBsAg levels were evaluated over 10 years. The results of routine liver biochemical function tests, including serum HBsAg levels for 1, 2, 5, and 10 years, and biometric information were obtained. Data of 90 patients were included for adaptive training. The predictive models were built based on algorithms set up by SONY Neural Network Console, and their accuracy was compared using statistical analysis. Multiple regression analysis revealed a mean absolute percentage error of 58%, and deep learning revealed a mean absolute percentage error of 15%; thus, deep learning is an accurate predictive discriminant tool. This study demonstrated the potential of deep learning algorithms to predict clinical outcomes.

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  • 患者まで届いている再生医療 より効果のある肝硬変症に対する再生医療の実現を目指して

    寺井 崇二, 土屋 淳紀, 渡邊 雄介, 竹内 卓, 野尻 俊介, 酒井 規裕, 木村 成宏, 阿部 寛幸

    再生医療   21 ( 1 )   20 - 23   2022.1

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  • Diet-related changes of basal lamina fenestrations in the villous epithelium of the rat small intestine: Statistical analysis on scanning electron microscopy.

    Masatoshi Sato, Keisuke Morita, Rie Azumi, Yusuke Mizutani, Manabu Hayatsu, Tatsuo Ushiki, Shuji Terai

    Biomedical research (Tokyo, Japan)   43 ( 1 )   11 - 22   2022

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    The epithelial basal lamina of the small intestine has numerous fenestrations for intraepithelial migration of leukocytes. We have reported dynamic changes of fenestrations in dietary conditions. To investigate this phenomenon, we performed statistical analyses using scanning electron microscopy images of the epithelial basal lamina of rat intestinal villi after removal of the villous epithelium by osmium maceration. We examined structural changes in the number and size of fenestrations in the rat jejunum and ileum under fasted and fed states for 24 h. Our findings revealed that, in the jejunum, the number of free cells migrating into the epithelium through fenestrations increased from 2 h after feeding, resulting in an increase in the fenestration size of intestinal villi; the number of free cells then tended to decrease at 6 h after feeding, and the fenestration size also gradually decreased. By contrast, the increase in the fenestration size by feeding was not statistically significant in the ileum. These findings indicate that the number of migrating cells increases in the upper part of the small intestine under dietary conditions, which may influence the absorption efficiency of nutrients including lipids, as well as the induction of nutrient-induced inflammation.

    DOI: 10.2220/biomedres.43.11

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  • Longitudinal increase in albumin-bilirubin score is associated with non-malignancy-related mortality and quality of life in patients with liver cirrhosis. International journal

    Akira Sakamaki, Masaaki Takamura, Norihiro Sakai, Yusuke Watanabe, Yoshihisa Arao, Naruhiro Kimura, Toru Setsu, Hiroyuki Abe, Takeshi Yokoo, Hiroteru Kamimura, Shunsuke Tsubata, Nobuo Waguri, Toru Ishikawa, Hirokazu Kawai, Soichi Sugitani, Tomomi Sato, Kazuhiro Funakoshi, Masashi Watanabe, Kentarou Igarashi, Kenya Kamimura, Atsunori Tsuchiya, Yutaka Aoyagi, Shuji Terai

    PloS one   17 ( 2 )   e0263464   2022

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    Due to the developments in the treatment for hepatitis, it is possible to prevent the progression of liver fibrosis and improve patients' prognosis even if it has already led to liver cirrhosis (LC). Consequently, a two-step study was conducted. To begin with, a retrospective study was conducted to identify the potential predictors of non-malignancy-related mortality from LC. Then, we prospectively analyzed the validity of these parameters as well as their association with patients' quality of life. In the retrospective study, 89 cases were included, and the multivariate Cox regression analysis indicated that age (P = 0.012), model for end-stage liver disease (MELD) score (P = 0.012), and annual rate of change of the albumin-bilirubin (ALBI) score (P < 0.001) were significantly associated with LC prognosis. In the prospective study, 70 patients were included, and the patients were divided into cirrhosis progression and non-progression groups. The univariate logistic regression analysis indicated the serum procollagen type III N-terminal peptide level (P = 0.040) and MELD score (P = 0.010) were significantly associated with the annual rate of change of the ALBI score. Furthermore, the mean Chronic Liver Disease Questionnaire score worsened from 5.3 to 4.9 in the cirrhosis progression group (P = 0.034). In conclusion, a longitudinal increase in the ALBI score is closely associated with non-malignancy-related mortality and quality of life.

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  • Esophageal Diverticulum - Indications and Efficacy of Therapeutic Endoscopy.

    Hiroki Sato, Manabu Takeuchi, Kazuya Takahashi, Ken-Ichi Mizuno, Koichi Furukawa, Akito Sato, Nao Nakajima, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   61 ( 7 )   943 - 949   2022

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    Objective Esophageal diverticulum is rare, and the concomitance of esophageal motility disorders (EMDs) and the efficacy of novel endoscopic treatment have not been investigated in Japan. Methods An examination including high-resolution manometry (HRM) was performed for patients with both EMDs and epiphrenic diverticulum. EMD-related epiphrenic diverticulum and Zenker's diverticulum were treated using salvage peroral endoscopic myotomy (s-POEM) and endoscopic diverticulotomy, respectively. Results Six cases of epiphrenic diverticulum were diagnosed in this study. Among 125 patients with achalasia and spastic disorders, concomitant epiphrenic diverticulum was observed in 4 (3.2%). Of these, three showed a normal lower esophageal sphincter pressure on HRM, although gastroscopy and esophagography revealed typical findings of an impaired lower esophageal sphincter relaxation. These four patients were successfully treated with s-POEM, and the Eckardt score improved from 6.3 to 0.25 at 32.5 (range: 13-56) months of follow-up, with equivalent treatment efficacy to that observed for achalasia and spastic disorders without epiphrenic diverticulum. In contrast, the two remaining cases of epiphrenic diverticulum had normal esophageal motility. Six cases of Zenker's diverticulum were diagnosed, and endoscopic diverticulotomy was successfully performed in all. The dysphagia score decreased from 2.8 to 0.17 at 14.8 (range: 2-36) months of follow-up. Overall, 12 endoscopic treatments were performed for esophageal diverticulum; no adverse events were observed. Conclusion In epiphrenic diverticulum patients, concomitant EMDs are not rare and should be carefully diagnosed. A normal lower esophageal sphincter pressure on HRM does not always mean a normal lower esophageal sphincter relaxation. S-POEM and endoscopic diverticulotomy are effective minimally invasive treatment options for EMD-related epiphrenic diverticulum and Zenker's diverticulum.

    DOI: 10.2169/internalmedicine.8196-21

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  • Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes. International journal

    Satoru Hashimoto, Hiroki Sato, Ken-Ichi Mizuno, Kazuya Takahashi, Masafumi Takatsuna, Junji Yokoyama, Hiroshi Ichikawa, Manabu Takeuchi, Masaaki Kobayashi, Shuji Terai

    Canadian journal of gastroenterology & hepatology   2022   1631415 - 1631415   2022

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    The incidence of gastric tube carcinoma (GTC) after esophagectomy for esophageal carcinoma has increased in recent years. Surgical removal of the reconstructed gastric tube is associated with high mortality, and endoscopic submucosal dissection (ESD) is a promising alternative. There are limited reports of ESD for GTC. This study investigated the efficacy and safety of ESD in GTC. This single-center retrospective study examined patients who underwent ESD for GTC after esophagectomy at our institution between 2003 and 2018. The curability of GTC with ESD was evaluated histologically according to the Japanese Gastric Cancer Treatment Guidelines. Patient characteristics and procedural and long-term outcomes were analyzed. Overall, 31 patients (29 men and 2 women; median age, 73 years) with 45 GTC lesions underwent ESD. The mean period between primary esophagectomy and the diagnosis of GTC was 10.6 years. Bleeding during ESD was noted in two patients (6.5%). No other adverse or fatal events such as perforation were noted. Complete resection and curative resection were documented in 80.6% and 48.4% of cases, respectively. The 3-year and 5-year overall survival rates were 67.6% and 47.7%, respectively. The 3-year and 5-year disease-specific survival rates were 100% and 92.9%, respectively. One patient died of GTC, and fourteen patients died of other diseases, including primary carcinoma in five cases. ESD was safe and provided good long-term outcomes in patients with GTC. Regular long-term gastroscopy is required for the early detection of GTC. Patients with GTC after esophagectomy for esophageal carcinoma have a high risk of other primary carcinomas or comorbidities after ESD.

    DOI: 10.1155/2022/1631415

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  • Hydrogen-producing small intestinal bacterial overgrowth is associated with hepatic encephalopathy and liver function. International journal

    Kunihiko Yokoyama, Akira Sakamaki, Kazuya Takahashi, Takumi Naruse, Chihiro Sato, Yuzo Kawata, Kentaro Tominaga, Hiroyuki Abe, Hiroki Sato, Atsunori Tsuchiya, Kenya Kamimura, Masaaki Takamura, Junji Yokoyama, Shuji Terai

    PloS one   17 ( 2 )   e0264459   2022

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    Overt hepatic encephalopathy (HE) is one of the complications of liver cirrhosis (LC), which negatively affects the prognosis and quality of life of patients. Small intestinal bacterial overgrowth (SIBO) is significantly associated with LC and its complications, including HE. We investigated the relationship between SIBO and LC, and the difference between hydrogen-producing and methane-producing SIBO (H-SIBO and M-SIBO, respectively). This is a prospective cohort study of 107 cases. Breath measurements of hydrogen and methane concentrations were performed for the diagnosis of SIBO. The study cohort included 81 males with a median age of 70 (40-86) years, and SIBO was detected in 31 cases (29.0%). There were no significant differences between the SIBO positive and SIBO negative groups. Reclassification into H-SIBO (16 cases) and others (91 cases) was performed, and the Child-Pugh score was only derived in the multivariate logistic analysis (P = 0.028, odds ratio 1.39, 95% confidence interval 1.04-1.85). Furthermore, H-SIBO was significantly associated with covert HE in chi-square test (50.0% vs. 24.2%, P = 0.034). In addition, we evaluated the therapeutic response on SIBO of rifaximin in eight covert HE patients. 20% patients with M-SIBO and 67% patients with H-SIBO showed an improvement of the breath test. In conclusion, H-SIBO, but not M-SIBO, is significantly associated with liver function, and rifaximin might be more effective for covert HE with H-SIBO. Therefore, the diagnosis of SIBO, including the classification as H-SIBO and M-SIBO, might help to determine the choice of treatment for HE.

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  • Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis

    Tahata, Y., Hikita, H., Mochida, S., Enomoto, N., Kawada, N., Kurosaki, M., Ido, A., Miki, D., Yoshiji, H., Takikawa, Y., Sakamori, R., Hiasa, Y., Nakao, K., Kato, N., Ueno, Y., Yatsuhashi, H., Itoh, Y., Tateishi, R., Suda, G., Takami, T., Nakamoto, Y., Asahina, Y., Matsuura, K., Yamashita, T., Kanto, T., Akuta, N., Terai, S., Shimizu, M., Sobue, S., Miyaki, T., Moriuchi, A., Yamada, R., Kodama, T., Tatsumi, T., Yamada, T., Takehara, T.

    Journal of Gastroenterology   57 ( 2 )   2022

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    DOI: 10.1007/s00535-021-01845-5

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  • Prognostic study of acute-on-chronic liver failure patients Usefulness of the fibrosis-4 index

    Watanabe, Y., Osaki, A., Waguri, N., Tsuchiya, A., Terai, S.

    Medicine (United States)   101 ( 44 )   2022

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    DOI: 10.1097/MD.0000000000031328

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  • Small G1 type III gastric neuroendocrine cell tumor showing scirrhous invasion and lymph node metastasis

    Sato, A., Sato, Y., Oka, H., Honda, Y., Terai, S.

    Gastrointestinal Endoscopy   95 ( 1 )   2022

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    DOI: 10.1016/j.gie.2021.09.029

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  • Small extracellular vesicles and liver diseases: From diagnosis to therapy

    Tsuchiya, A., Natsui, K., Ishii, Y., Koseki, Y., Takeda, N., Tomiyoshi, K., Yamazaki, F., Yoshida, Y., Terai, S.

    World Journal of Hepatology   14 ( 7 )   2022

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    DOI: 10.4254/wjh.v14.i7.1307

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  • Tumor-to-tumor metastasis of colon cancer metastasizing to a pancreatic neuroendocrine tumor associated with von Hippel-Lindau disease: a case report

    Natsui, H., Kohisa, J., Yoshikawa, S., Takeuchi, M., Yagi, R., Minagawa, M., Tani, T., Usuda, H., Terai, S.

    Clinical Journal of Gastroenterology   15 ( 6 )   2022

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    DOI: 10.1007/s12328-022-01684-8

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  • Two cases of portal-systemic encephalopathy caused by multiple portosystemic shunts successfully treated with percutaneous transhepatic obliteration

    Watanabe, Y., Osaki, A., Yamazaki, S., Yamazaki, H., Kimura, K., Takaku, K., Sato, M., Waguri, N., Terai, S.

    Clinical Journal of Gastroenterology   15 ( 5 )   2022

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  • Needle tract seeding after endoscopic ultrasound-guided tissue acquisition of pancreatic tumors: Nationwide survey in Japan

    Kitano, M., Yoshida, M., Ashida, R., Kita, E., Katanuma, A., Itoi, T., Mikata, R., Nishikawa, K., Matsubayashi, H., Takayama, Y., Kato, H., Takenaka, M., Ueki, T., Kawashima, Y., Nakai, Y., Hashimoto, S., Shigekawa, M., Nebiki, H., Tsumura, H., Okabe, Y., Ryozawa, S., Harada, Y., Mitoro, A., Sasaki, T., Yasuda, H., Miura, N., Ikemoto, T., Ozawa, E., Shioji, K., Yamaguchi, A., Okuzono, T., Moriyama, I., Hisai, H., Fujita, K., Goto, T., Shirahata, N., Iwata, Y., Okabe, Y., Hara, K., Hashimoto, Y., Kuwatani, M., Isayama, H., Fujimori, N., Masamune, A., Hatamaru, K., Shimokawa, T., Okazaki, K., Takeyama, Y., Yamaue, H., Abue, M., Aiura, K., Akashi, T., Akiyama, T., Aoyagi, H., Araki, M., Arizumi, T., Aruga, Y., Asada, M., Asai, S., Baba, T., Ban, S., Chinen, K., Doi, S., Eguchi, T., Endo, M., Endo, S., Ezaki, T., Fujii, K., Fujii, M., Fujimori, M., Fujimoto, Y., Fujita, Y., Fujita, Y., Fukasawa, M., Fukuba, N., Fukuchi, S., Fukuda, K., Furukawa, M., Furumatsu, K., Hakamada, K., Hanada, K., Harada, K., Harano, M., Hashigo, S., Hashiguchi, K., Hayashi, K., Hayashi, N., Hayatsu, S., Hijioka, S., Hirano, A., Hirao, M., Hirooka, Y., Hirota, M., Horino, K., Hotta, Y., Ijima, M., Ikuta, Y., Imakiire, K., Imamura, T., Inatomi, O., Inoue, T., Irisawa, A., Ishida, E., Ishihara, K., Ishii, S., Ishii, T., Ito, H., Ito, J., Ito, T., Iwahashi, K., Iwano, H., Iwasaki, E., Iwashita, T., Iwata, K., Kakimoto, T., Kaku, T., Kamochi, J., Kanamori, A., Kaneto, H., Karasaki, H., Kato, Y., Kawaguchi, Y., Kawakami, H., Kawase, T., Kawashima, H., Kikuyama, M., Kimura, K., Kimura, T., Kitamura, K., Kobashigawa, K., Kobayashi, A., Kobayashi, K., Kobayashi, M., Kodama, R., Kodama, Y., Koike, Y., Komaki, T., Komura, T., Kondo, H., Kondo, H., Koshita, S., Koya, T., Ku, Y., Kuriyama, K., Kuroda, T., Kuroki, M., Kuroki, T., Kushiyama, Y., Maekawa, H., Makino, N., M, ai, K., Maruyama, H., Maruyama, M., Matsubara, S., Matsumoto, R., Matsunaga, K., Matsusaki, S., Matsushita, A., Mihara, M., Miyaike, J., Miyata, H., Miyoshi, H., Mizuno, S., Morita, T., Mouri, T., Mukai, T., Murakami, K., Nagano, H., Nakahara, K., Nakahara, O., Nakai, Y., Nakaji, S., Nakajima, J., Nakanishi, F., Nakano, Y., Nakashima, S., Naota, H., Nishida, N., Nishide, T., Nishikiori, H., Nomura, Y., Ochi, Y., Ochiai, T., Oe, S., Ogura, T., Ohata, A., Ohshima, T., Ohtsubo, K., Oka, H., Okazaki, A., Okochi, O., Onishi, Y., Otsuka, Y., Sagami, R., Sakakihara, I., Sakata, T., Sasahira, N., Sasaki, A., Sato, H., Sato, S., Sato, T., Satoh, A., Sekine, M., Sen-yo, M., Serikawa, M., Shibuya, H., Shimizu, S., Shinzato, M., Shitani, M., Suda, T., Sugimori, K., Sumi, H., Suzuki, N., Suzuki, R., Suzuki, Y., Tadauchi, A., Takahashi, K., Takahashi, K., Takaya, H., Takeda, Y., Takeda, O., Takihara, H., Tanaka, Y., Tanno, S., Tawada, K., Taya, Y., Terai, S., Terauchi, T., Togashi, J., Toki, M., Toyama, T., Tsuda, H., Tsugeno, H., Tsutsui, S., Uchida, K., Ueki, T., Usuba, T., Uza, N., Wakiyama, S., Watanabe, M., Yagi, Y., Yamada, R., Yamamoto, R., Yamazaki, M., Yasuda, I., Yawata, A., Yokota, T., Yokoyama, K., Yoshida, K., Yoshikawa, S., Yoshikawa, T.

    Digestive Endoscopy   34 ( 7 )   2022

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    DOI: 10.1111/den.14346

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  • Characteristics of colorectal neuroendocrine tumors in patients prospectively enrolled in a Japanese multicenter study: a first report from the C-NET STUDY

    Sekiguchi, M., Hotta, K., Takeuchi, Y., Tanaka, S., Yamamoto, H., Shinmura, K., Harada, K., Uraoka, T., Hisabe, T., Sano, Y., Kondo, H., Horimatsu, T., Kikuchi, H., Kawamura, T., Nagata, S., Yamamoto, K., Tajika, M., Tsuji, S., Kusaka, T., Okuyama, Y., Yoshida, N., Moriyama, T., Hasebe, A., So, S., Kobara, H., Kashida, H., Miyanaga, R., Kato, S., Hayashi, Y., Sada, M., Fukuzawa, M., Kato, H., Takayama, T., Konishi, J., Matsushita, H.-O., Narasaka, T., Ohata, K., Togashi, K., Nakamura, H., Moriichi, K., Oda, Y., K, a, N., Kuwai, T., Terai, S., Sanomura, M., Kitamura, S., Miyamoto, H., Kiriyama, S., Mizuno, C., Saito, Y., Sekine, S., Ito, S., Nakahira, H., Oka, S., Hayashi, Y., Yoshimura, K., Ishikawa, H., Matsuda, T.

    Journal of Gastroenterology   57 ( 8 )   2022

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    DOI: 10.1007/s00535-022-01877-5

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  • Gastric alarmin release: A warning signal in the development of gastric mucosal diseases

    Wu, E., Zhu, J., Ma, Z., Tuo, B., Terai, S., Mizuno, K., Li, T., Liu, X.

    Frontiers in Immunology   13   2022

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    DOI: 10.3389/fimmu.2022.1008047

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  • Steroid therapy still plays a crucial role and could serve as a bridge to the next promising treatments in patients with IgG4-related sclerosing cholangitis: Results of a Japanese nationwide study

    Kubota, K., Kamisawa, T., Nakazawa, T., Tanaka, A., Naitoh, I., Takikawa, H., Unno, M., Kawa, S., Masamune, A., Nakamura, S., Okazaki, K., Furumatsu, K., Sawai, S., Goto, T., Okumura, T., Suzuki, D., Otsuka, M., Kobori, I., Tamano, M., Koizumi, M., Hiasa, Y., Kawabe, N., Hirooka, Y., Yamamoto, S., Asano, Y., Inui, K., Horiguchi, A., Watanabe, H., Toya, D., Hatayama, K., Ueki, T., Kinoshita, N., Sugimoto, M., Ohira, H., Mukai, T., Tomita, E., Iwata, K., Shimizu, S., Suetsugu, J., Shimizu, M., Tsuji, K., Ishida, R., Ito, M., Furukawa, R., Sakamoto, N., Araki, M., Tanno, S., Sakamoto, Y., Ito, T., Takai, S., Ikeya, S., Yamada, T., Kudara, N., Shimizu, A., Hanada, K., Ichiki, Y., Kitada, H., Hifumi, M., Kimura, H., Kurosaki, M., Izumi, N., Sumi, H., Haruta, Hayashi, K., Harada, R., Inoue, M., Nakamura, S., Ito, T., Tomishima, K., Isayama, H., Oura, K., Masaki, T., Shimokawahara, N., Tanoue, S., Maemura, K., Ido, A., Mizushima, I., Kawano, M., Yoshida, K., Naganuma, M., Murata, M., Nishio, A., Fujita, Y., Teratani, T., Matsubara, S., Tamai, H., Yoshida, Y., Azemoto, R., Kamata, K., Watanabe, T., Kurosu, T., Koizumi, W., Fujita, J., Seki, H., Ueda, Y., Fukumoto, T., Kousaki, T., Uchida, K., Ochiai, T., Kawasaki, T., Tanaka, M., Ishida, E., Notohara, K., Mori, H., Mori, T., Kawabata, H., Miyata, M., Sakagami, J., Itoh, Y., Shiokawa, M., Seno, H., Watanabe, N., Naitoh, I., Kataoka, H., Aoki, T., Fujishiro, M., Niihara, T., Nishimata, H., Mitoro, A., Yoshiji, H., Yoshida, M., Ikeda, M., Tomita, K., Hokari, R., Hayasaka, K., Amano, Y., Shioji, K., Hayashi, K., Terai, S., Nakajima, M., Yamahana, J., Matsumoto, R., Kikuchi, H., Kanamori, A., Kiriyama, S., Iwatsu, S., Kato, Y., Horiguchi, S., Yagi, T., Okada, H., Ohkawa, K., Hirao, M., Hiramatsu, N., Oza, N., Imamura, H., Baba, T., Nakano, S., Shinobi, T., Ryozawa, S., Motoya, M., Nakase, H., Kinoshita, N., Ito, K., Miyake, T., Kohge, N., Tobita, H., Joshita, S., Umemura, T., Kawaguchi, S., Ohno, K., Sonobe, K., Satoh, A., Shimosegawa, T., Miura, F., Yagi, M., Sano, K., Kin, T., Katanuma, A., Koike, K., Miura, S., Kawashima, Y., Kagawa, T., Azuma, S., Watanabe, M., Honjyo, M., Itoi, T., Honda, A., Kobayashi, K., Asano, T., Mizuno, S., Koike, K., Nishino, T., Taniguchi, H., Tajiri, K., Yasuda, I., Tanaka, Y., Oe, S., Harada, M., Kurata, M., Fukasawa, M., Enomoto, N., Kawaji, Y., Kitano, M., Nishise, Y., Hirakawa, H., Ishizawa, T., Ueno, Y., Kaino, M., Fujimoto, Y., Sakaida, I.

    Journal of Hepato-Biliary-Pancreatic Sciences   29 ( 8 )   2022

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    DOI: 10.1002/jhbp.1157

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  • A rare case of duodenal variceal bleeding due to extrahepatic portal vein obstruction successfully treated with endoscopic injection sclerotherapy

    Hori, A., Watanabe, Y., Takahashi, K., Tonouchi, T., Kimura, N., Setsu, T., Ikarashi, S., Kamimura, H., Yokoyama, J., Terai, S.

    Clinical Journal of Gastroenterology   15 ( 3 )   2022

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    DOI: 10.1007/s12328-022-01627-3

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  • A difficult-to-diagnose case of Borrmann type IV gastric cancer with marked transverse colon stenosis

    Natsui, K., Maruyama, M., Terai, S.

    JGH Open   6 ( 11 )   2022

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    DOI: 10.1002/jgh3.12832

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  • The Visceral-to-subcutaneous Adipose Tissue Area Ratio Is Associated with Retreatment in Chronic Pancreatitis Patients with Pancreatolithiasis after Extracorporeal Shock Wave Lithotripsy

    Yokoyama, K., Takamura, M., Watanabe, J., Nakamura, A., Sato, Y., Sekine, A., Terai, S.

    Internal Medicine   61 ( 24 )   2022

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    DOI: 10.2169/internalmedicine.9038-21

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  • Environmental factors, medical and family history, and comorbidities associated with primary biliary cholangitis in Japan: a multicenter case–control study

    Matsumoto, K., Ohfuji, S., Abe, M., Komori, A., Takahashi, A., Fujii, H., Kawata, K., Noritake, H., Tadokoro, T., Honda, A., Asami, M., Namisaki, T., Ueno, M., Sato, K., Kakisaka, K., Arakawa, M., Ito, T., Tanaka, K., Matsui, T., Setsu, T., Takamura, M., Yasuda, S., Katsumi, T., Itakura, J., Sano, T., Tamura, Y., Miura, R., Arizumi, T., Asaoka, Y., Uno, K., Nishitani, A., Ueno, Y., Terai, S., Takikawa, Y., Morimoto, Y., Yoshiji, H., Mochida, S., Ikegami, T., Masaki, T., Kawada, N., Ohira, H., Tanaka, A.

    Journal of Gastroenterology   57 ( 1 )   2022

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    DOI: 10.1007/s00535-021-01836-6

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  • Delayed and Synchronous Recurrence of Breast Cancer Metastases in Multiple Organs

    Owaki, T., Hashimoto, S., Umezu, H., Terai, S.

    Internal Medicine   61 ( 22 )   2022

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    DOI: 10.2169/internalmedicine.8728-21

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  • Intrahepatic Bile Duct Foreign Body With Cholangitis After Pylorus-preserving Pancreatoduodenectomy: Is It a Fish Bone?

    Natsui, K., Maruyama, M., Terai, S.

    Gastroenterology   163 ( 4 )   2022

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    DOI: 10.1053/j.gastro.2022.05.017

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  • Endoscopic Findings and Treatment of Gastric Neoplasms in Familial Adenomatous Polyposis

    Sato, C., Takahashi, K., Sato, H., Naruse, T., Nakajima, N., Takatsuna, M., Mizuno, K.-I., Hashimoto, S., Takeuchi, M., Yokoyama, J., Kobayashi, M., Terai, S.

    Journal of Gastric Cancer   22 ( 4 )   2022

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    DOI: 10.5230/jgc.2022.22.e30

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  • Case report: New subtype of gastric adenocarcinoma arising from an H. pylori infection-negative stomach: Foveolar epithelium and mucous neck cell-mixed type adenocarcinoma

    Liu, X., Wu, X., Zhu, J., Yagi, K., Ajioka, Y., Terai, S., Mizuno, K., Li, H., Tuo, B., Di, L.

    Frontiers in Oncology   12   2022

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    DOI: 10.3389/fonc.2022.970231

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  • Benign Duodenal Stenosis Caused by Huge Mesenteric Hematoma Conservatively Improved with Long-term Use of Double Elementary Diet Tube

    Setsu, T., Yokoo, T., Sato, T., Kumagai, M., Motegi, S., Kawata, Y., Ogawa, K., Mizuno, K.-I., Terai, S.

    Internal Medicine   61 ( 13 )   2022

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    DOI: 10.2169/internalmedicine.8721-21

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  • Gravity assistance enables liver stiffness measurements to detect liver fibrosis under congestive circumstances

    Suda, T., Sugimoto, A., Kanefuji, T., Abe, A., Yokoo, T., Hoshi, T., Abe, S., Morita, S., Yagi, K., Takahashi, M., Terai, S.

    World Journal of Hepatology   14 ( 4 )   2022

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    DOI: 10.4254/wjh.v14.i4.778

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  • Combination therapy of Juzentaihoto and mesenchymal stem cells attenuates liver damage and regresses fibrosis in mice. International journal

    Takahiro Iwasawa, Shunsuke Nojiri, Atsunori Tsuchiya, Suguru Takeuchi, Takayuki Watanabe, Masahiro Ogawa, Satoko Motegi, Takeki Sato, Masaru Kumagai, Taiki Nakaya, Katsuya Ohbuchi, Miwa Nahata, Naoki Fujitsuka, Masaaki Takamura, Shuji Terai

    Regenerative therapy   18   231 - 241   2021.12

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    Background: Liver cirrhosis is an end-stage multiple liver disease. Mesenchymal stem cells (MSCs) are an attractive cell source for reducing liver damage and regressing fibrosis; additional therapies accompanying MSCs can potentially enhance their therapeutic effects. Kampo medicines exhibit anti-inflammatory and anti-oxidative effects. Here, we investigated the therapeutic effect of MSCs combined with the Kampo medicine Juzentaihoto (JTT) as a combination therapy in a carbon tetrachloride (CCl4)-induced cirrhosis mouse model. Methods: C57BL/6 mice were administered JTT (orally) and/or MSCs (one time, intravenously). The levels of liver proteins were measured in the sera. Sirius Red staining and hydroxyproline quantitation of hepatic tissues and immune cells were conducted, and their associated properties were evaluated. Liver metabolomics of liver tissues was performed. Results: JTT monotherapy attenuated liver damage and increased serum albumin level, but it did not effectively induce fibrolysis. JTT rapidly reduced liver damage, in a dose-dependent manner, after a single-dose CCl4 administration. Furthermore, JTT-MSC combination therapy attenuated liver damage, improved liver function, and regressed liver fibrosis. The combination increased the CD4+/CD8+ ratio. JTT had stronger effects on NK and regulatory T cell induction, whereas MSCs more strongly induced anti-inflammatory macrophages. The combination therapy further induced anti-inflammatory macrophages. JTT normalized lipid mediators, and tricarboxylic acid cycle- and urea cycle-related mediators effectively. Conclusions: The addition of JTT enhanced the therapeutic effects of MSCs; this combination could be a potential treatment option for cirrhosis.

    DOI: 10.1016/j.reth.2021.07.002

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  • Nationwide survey for patients with acute-on-chronic liver failure occurring between 2017 and 2019 and diagnosed according to proposed Japanese criteria

    Nobuaki Nakayama, Hayato Uemura, Yoshihito Uchida, Yukinori Imai, Tomoaki Tomiya, Shuji Terai, Hitoshi Yoshiji, Takuya Genda, Akio Ido, Kazuaki Inoue, Naoya Kato, Isao Sakaida, Masahito Shimizu, Yasuhiro Takikawa, Masanori Abe, Ryuzo Abe, Kazuaki Chayama, Kiyoshi Hasegawa, Ayano Inui, Mureo Kasahara, Hiromasa Ohira, Atsushi Tanaka, Hajime Takikawa, Satoshi Mochida

    Journal of Gastroenterology   56 ( 12 )   1092 - 1106   2021.12

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    DOI: 10.1007/s00535-021-01834-8

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    Other Link: https://link.springer.com/article/10.1007/s00535-021-01834-8/fulltext.html

  • 【再生医療への期待〜各疾患領域における現況と展望〜】肝臓領域における細胞を用いた再生医療の将来展望

    寺井 崇二, 渡邊 雄介, 土屋 淳紀

    Pharma Medica   39 ( 12 )   37 - 40   2021.12

  • アルコール性肝硬変におけるB型肝炎ウイルス感染の発癌と予後に対する関与についての検討

    坂牧 僚, 小山 究太郎, 森田 真一, 阿部 寛幸, 上村 顕也, 高村 昌昭, 寺井 崇二

    アルコールと医学生物学   40   47 - 49   2021.12

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  • New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction. International journal

    Hiroki Sato, Hiroyuki Ogihara, Kazuya Takahashi, Yuzo Kawata, Yuichi Kojima, Kentaro Tominaga, Junji Yokoyama, Yoshihiko Hamamoto, Shuji Terai

    Scientific reports   11 ( 1 )   22974 - 22974   2021.11

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    Chronic intestinal pseudo-obstruction (CIPO) is a severe and refractory intestinal motility disorder whose diagnosis currently relies on subjective imaging assessments. Cine magnetic resonance imaging (MRI) may potentially improve the quantitative analysis of gastrointestinal motility; however, suitable CIPO detection parameters should be determined. Cine MRI was performed in seven patients with CIPO and 11 healthy controls. The logarithm of the Mahalanobis distance (x1) and distance variation per time (x2) were used as the original parameters to determine CIPO diagnostic thresholds. Furthermore, the correlation between cine MRI findings and CIPO severity was investigated. Threshold values of α = 1.10 and β = 0.15 for x1 and x2, respectively, produced a CIPO diagnosis sensitivity of 1.00 (7/7) and specificity of 0.82 (9/11). The resulting error was 0.11 (2/18). The two parameters were correlated (Pearson's correlation coefficient: - 0.52). Any of the intestinal tracts of patients with severe CIPO requiring home parenteral nutrition belonged to the region defined by x1 ≥ 1.10 and x2 ≤ 0.15. Cine MRI is effective for the quantitative evaluation of small intestinal motility and CIPO diagnosis when using the abovementioned parameters and can be useful for treatment decision-making. However, these parameters have a wide distribution in healthy volunteers; this may complicate the detection of other disorders.

    DOI: 10.1038/s41598-021-02268-1

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  • The risk of cirrhosis and its complications based on PNPLA3 rs738409 G allele frequency. International journal

    Xue Shao, Haruki Uojima, Taeang Arai, Yuji Ogawa, Toru Setsu, Masanori Atsukawa, Yoshihiro Furuichi, Yoshitaka Arase, Kazue Horio, Hisashi Hidaka, Takahide Nakazawa, Makoto Kako, Tatehiro Kagawa, Katsuhiko Iwakiri, Atsushi Nakajima, Shuji Terai, Yasuhito Tanaka, Wasaburo Koizumi

    Digestive diseases (Basel, Switzerland)   40 ( 5 )   625 - 634   2021.11

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    BACKGROUND: Data regarding the influence of patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism for patients with liver cirrhosis (LC) are scarce. OBJECTIVE: This study assesses the role of the PNPLA3 polymorphism for the development of LC and its complications by the findings of genetic examinations. METHODS: Patients with LC caused by virus (n = 157), alcohol (n = 104), nonalcoholic fatty liver disease (NAFLD) (n = 106), or autoimmune disease (n = 33) and without LC (n = 128) were enrolled. LC were composed of the present and absent of complications, such as variceal bleeding, hepatic ascites, and/or hepatic encephalopathy. To assess the role of the PNPLA3 polymorphism, odds ratio (OR) for the rs738409 variant was calculated for the patients between (i) with LC and without LC in the entire cohort, and (ii) the present and absent of complications in the patients with LC. RESULTS: There was a significant difference among the patients without LC and those with alcohol, NAFLD related LC in the frequency of G alleles (p < 0.001, both). According to complications of LC, the OR for NAFLD related cirrhosis significantly increased in the presence of the two mutated alleles (OR = 3.165; p = 0.046) when the wild type was used as the reference. However, there were no significant risks for the complications in the virus and alcohol related cirrhosis unless there was a presence of G alleles. CONCLUSION: The PNPLA3 polymorphism was associated with the risk of NAFLD related LC and its complications.

    DOI: 10.1159/000521062

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  • Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study. International journal

    Hiroki Sato, Yohei Nishikawa, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shuji Terai, Haruhiro Inoue

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   34 ( 5 )   965 - 973   2021.11

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    OBJECTIVES: Indications for peroral endoscopic myotomy (POEM) and endoscopic submucosal dissection (ESD) in patients with achalasia concomitant with esophageal carcinoma (EC) are unclear. This study aimed to clarify the role of POEM in cases of achalasia concomitant with EC and to elucidate the indications for ESD and efficient surveillance for EC. METHODS: We conducted a multicenter cohort study at 14 hospitals in Japan, including 3707 cases of achalasia-related esophageal motility disorders (EMDs). Factors contributing to EC risk, the characteristics of EC, and clinical outcomes of POEM/ESD were analyzed. RESULTS: In patients undergoing POEM, screening and surveillance endoscopy throughout a 1-year period resulted in diagnosis of 72.1% new EC cases. Of 62 patients with 123 ECs, 40.3% had multiple or metachronous lesions within 37.5 months. EC was predominantly observed in the middle thoracic esophagus (58.5%) and posteriorly (73.2%). POEM had comparable safety and efficacy in cases of concomitant EC even after ESD. Endoscopic en bloc resection was performed in 95.8% and 89.3% of ECs diagnosed before and after POEM, respectively (P = 0.351); however, ESD on the POEM-line was impaired by fibrosis. Multivariate analysis revealed risk factors for EC, including regular alcohol consumption, a history of smoking, advanced age, and extended disease duration. Alcohol intake and smoking had a synergistic effect on EC development. CONCLUSIONS: Screening and surveillance of POEM help in detecting EC. ESD is feasible in achalasia, although on the POEM-line is challenging. Surveillance endoscopy for EC is recommended for cases with specific risks and a history of ECs.

    DOI: 10.1111/den.14197

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  • 脾動脈瘤破裂を契機にC型肝炎治療に至った肝硬変の1例

    北條 雄暉, 上村 博輝, 大脇 崇史, 木村 莉菓, 岩澤 貴宏, 渡邊 雄介, 高綱 将史, 五十嵐 聡, 高村 昌昭, 薛 徹, 荒生 祥尚, 堀井 陽祐, 佐藤 辰彦, 寺井 崇二

    肝臓   62 ( 11 )   749 - 755   2021.11

  • 脾動脈瘤破裂を契機にC型肝炎治療に至った肝硬変の1例

    北條 雄暉, 上村 博輝, 大脇 崇史, 木村 莉菓, 岩澤 貴宏, 渡邊 雄介, 高綱 将史, 五十嵐 聡, 高村 昌昭, 薛 徹, 荒生 祥尚, 堀井 陽祐, 佐藤 辰彦, 寺井 崇二

    肝臓   62 ( 11 )   749 - 755   2021.11

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  • 【肝不全・肝硬変に対する再生療法-最先端の今】開発中の肝再生医療 間葉系幹細胞,マクロファージ,エクソソームを用いた再生療法

    土屋 淳紀, 寺井 崇二

    臨床消化器内科   36 ( 13 )   1647 - 1652   2021.11

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  • 【肝不全・肝硬変に対する再生療法-最先端の今】基礎的知見の進歩 自律神経経路を介した臓器連関と肝再生

    上村 顕也, 井上 良介, 名古屋 拓郎, 高 昌良, 大脇 崇史, 寺井 崇二

    臨床消化器内科   36 ( 13 )   1623 - 1628   2021.11

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  • 【肝硬変は治るか?組織改築改善・研究の最前線】トランスレーショナルリサーチ 間葉系幹細胞、エクソソームを用いた肝硬変治療

    土屋 淳紀, 寺井 崇二

    医学のあゆみ   279 ( 8 )   790 - 794   2021.11

  • Rapid progression of colonic mucinous adenocarcinoma with immunosuppressive condition: A case report and review of literature. International journal

    Youhei Koseki, Kenya Kamimura, Yuto Tanaka, Marina Ohkoshi-Yamada, Qiliang Zhou, Yoshifumi Matsumoto, Takeshi Mizusawa, Hiroki Sato, Akira Sakamaki, Hajime Umezu, Junji Yokoyama, Shuji Terai

    World journal of clinical cases   9 ( 30 )   9182 - 9191   2021.10

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    BACKGROUND: Colorectal mucinous adenocarcinoma is a rare subtype of colorectal cancer and is characterized by an abundance of mucin in the tumor. In addition, the colorectal mucinous adenocarcinoma often demonstrates poor differentiation in the histology of tumor cells and poor prognosis compared with those with adenocarcinoma. Here, we present the case of a young woman with colonic mucinous adenocarcinoma showing significantly rapid progression within four months of immunosuppressant therapy for Henoch-Schönlein purpura. CASE SUMMARY: Here we report a rare case of ascending colon mucinous adenocarcinoma with lymph node and liver metastases which developed and progressed rapidly within four months during the treatment of Henoch-Schönlein purpura using corticosteroids. The systemic screening examinations showed no tumors before the immunosuppressant therapy. Fortunately, the patient was successfully treated with chemotherapy. CONCLUSION: While no direct evidence that the immunosuppressants accelerated the tumor development, the case presenta tion and review of the literature demonstrated that surveillance for malignancies before and during treatment with immunosuppressive agents is essential.

    DOI: 10.12998/wjcc.v9.i30.9182

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  • 胆管への浸潤を伴う胆管内乳頭状粘液性腺癌 1症例報告(Intraductal papillary mucinous adenocarcinoma with bile duct invasion: A case report)

    水戸 將貴, 戸田 遼, 木村 究, 小島 雄一, 小川 光平, 木村 成宏, 荒生 祥尚, 五十嵐 聡, 林 和直, 土屋 淳紀, 寺井 崇二, 加藤 卓, 味岡 洋一, 石川 博補, 滝沢 一泰, 若井 俊文

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   69回・91回   53 - 53   2021.10

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  • Rare complication of hepatocellular carcinoma in Wilson's disease. International journal

    Marina Ohkoshi-Yamada, Kenya Kamimura, Hiroteru Kamimura, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   5 ( 10 )   1220 - 1222   2021.10

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    The complication of hepatocellular carcinoma (HCC) in Wilson's disease is rare. Wilson's disease treatment using D-penicillamine (DPA) is useful to prevent HCC occurrence; however, it also causes iron accumulation and synergistic radical formation in the liver, which may enhance carcinogenesis. Reported herein is a case of HCC in Wilson's disease treated with DPA for 36 years. The tumor was surgically resected and histologically diagnosed with moderately differentiated HCC surrounded by cirrhotic tissue with fatty infiltration. Rhodanine staining revealed a slight positively stained area in both tumor and surrounding tissues. Information obtained from this case and literature review highlight the feature of HCC in Wilson's disease.

    DOI: 10.1002/jgh3.12648

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  • 自律神経経路を介した臓器連関と肝疾患

    上村 顕也, 大脇 崇史, 高 昌良, 永山 逸夫, 名古屋 拓郎, 井上 良介, 上野 将紀, 寺井 崇二

    日本自律神経学会総会プログラム・抄録集   74回   87 - 87   2021.10

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  • 胆管への浸潤を伴う胆管内乳頭状粘液性腺癌 1症例報告(Intraductal papillary mucinous adenocarcinoma with bile duct invasion: A case report)

    水戸 將貴, 戸田 遼, 木村 究, 小島 雄一, 小川 光平, 木村 成宏, 荒生 祥尚, 五十嵐 聡, 林 和直, 土屋 淳紀, 寺井 崇二, 加藤 卓, 味岡 洋一, 石川 博補, 滝沢 一泰, 若井 俊文

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   69回・91回   53 - 53   2021.10

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  • 原発性胆汁性胆管炎患者の予後を最もよく予想する治療反応性判定Criteriaについて

    木村 成宏, 高村 昌昭, 武田 信峻, 荒生 祥尚, 高綱 将史, 渡邉 雄介, 竹内 卓, 阿部 寛幸, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増大会 )   A698 - A698   2021.10

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  • 消化器診療におけるサルコペニアの意義 1-kestoseが高齢サルコペニアの腸内細菌と筋肉量に与える影響

    冨永 顕太郎, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増大会 )   A461 - A461   2021.10

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  • 有症化した症候性巨大肝嚢胞に対して、ミノサイクリン硬化療法が著効した一例

    木南 佳也, 小川 和也, 石井 壮一, 遠藤 沙織, 石川 夏生, 阿部 寛幸, 佐藤 裕樹, 坂牧 僚, 上村 顕也, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   69回・91回   93 - 93   2021.10

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  • 消化器診療におけるサルコペニアの意義 1-kestoseが高齢サルコペニアの腸内細菌と筋肉量に与える影響

    冨永 顕太郎, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増大会 )   A461 - A461   2021.10

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  • 原発性胆汁性胆管炎患者の予後を最もよく予想する治療反応性判定Criteriaについて

    木村 成宏, 高村 昌昭, 武田 信峻, 荒生 祥尚, 高綱 将史, 渡邉 雄介, 竹内 卓, 阿部 寛幸, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増大会 )   A698 - A698   2021.10

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  • 有症化した症候性巨大肝嚢胞に対して、ミノサイクリン硬化療法が著効した一例

    木南 佳也, 小川 和也, 石井 壮一, 遠藤 沙織, 石川 夏生, 阿部 寛幸, 佐藤 裕樹, 坂牧 僚, 上村 顕也, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   69回・91回   93 - 93   2021.10

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  • Interventional EUS超音波内視鏡下瘻孔形成術の現状と問題点(膵) 重症急性膵炎後Walled-off necrosisの自然軽快に関連する因子

    五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増大会 )   A550 - A550   2021.10

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  • 大腸がん検診を受診しない理由に関するアンケート調査

    水野 研一, 川田 雄三, 林 和直, 寺井 崇二, 中島 尚

    日本消化器病学会雑誌   118 ( 臨増大会 )   A706 - A706   2021.10

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  • 超音波内視鏡システムにおける音速補正モードの膵癌診断における有用性の検討

    林 和直, 小川 光平, 五十嵐 聡, 寺井 崇二

    Gastroenterological Endoscopy   63 ( Suppl.2 )   2046 - 2046   2021.10

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  • Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice. International journal

    Shunsuke Nojiri, Atsunori Tsuchiya, Kazuki Natsui, Suguru Takeuchi, Takayuki Watanabe, Yuichi Kojima, Yusuke Watanabe, Hiroteru Kamimura, Masahiro Ogawa, Satoko Motegi, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Yui Ishii, Tomomi Kitayama, Yu-Tung Li, Yuya Ouchi, Takashi Shimbo, Masaaki Takamura, Katsuto Tamai, Shuji Terai

    Inflammation and regeneration   41 ( 1 )   28 - 28   2021.9

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    The liver has a high regenerative ability and can induce spontaneous regression of fibrosis when early liver damage occurs; however, these abilities are lost when chronic liver damage results in decompensated cirrhosis. Cell therapies, such as mesenchymal stem cell (MSC) and macrophage therapies, have attracted attention as potential strategies for mitigating liver fibrosis. Here, we evaluated the therapeutic effects of HMGB1 peptide synthesized from box A of high mobility group box 1 protein. Liver damage and fibrosis were evaluated using a carbon tetrachloride (CCl4)-induced cirrhosis mouse model. The effects of HMGB1 peptide against immune cells were evaluated by single-cell RNA-seq using liver tissues, and those against monocytes/macrophages were further evaluated by in vitro analyses. Administration of HMGB1 peptide did not elicit a rapid response within 36 h, but attenuated liver damage after 1 week and suppressed fibrosis after 2 weeks. Fibrosis regression developed over time, despite continuous liver damage, suggesting that administration of this peptide could induce fibrolysis. In vitro analyses could not confirm a direct effect of HMGB1 peptide against monocyte/macrophages. However, macrophages were the most affected immune cells in the liver, and the number of scar-associated macrophages (Trem2+Cd9+ cells) with anti-inflammatory markers increased in the liver following HMGB1 treatment, suggesting that indirect effects of monocytes/macrophages were important for therapeutic efficacy. Overall, we established a new concept for cell-free therapy using HMGB1 peptide for cirrhosis through the induction of anti-inflammatory macrophages.

    DOI: 10.1186/s41232-021-00177-4

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  • Transition of clinical and basic studies on liver cirrhosis treatment using cells to seek the best treatment. International journal

    Shuji Terai, Atsunori Tsuchiya, Yusuke Watanabe, Suguru Takeuchi

    Inflammation and regeneration   41 ( 1 )   27 - 27   2021.9

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    The liver is a highly regenerative organ; however, its regeneration potential is reduced by chronic inflammation with fibrosis accumulation, leading to cirrhosis. With an aim to tackle liver cirrhosis, a life-threatening disease, trials of autologous bone marrow cell infusion (ABMi) therapy started in 2003. Clinical studies revealed that ABMi attenuated liver fibrosis and improved liver function in some patients; however, this therapy has some limitations such as the need of general anesthesia. Following ABMi therapy, studies have focused on specific cells such as mesenchymal stromal cells (MSCs) from a variety of tissues such as bone marrow, adipose tissue, and umbilical cord tissues. Particularly, studies have focused on gaining mechanistic insights into MSC distribution and effects on immune cells, especially macrophages. Several basic studies have reported the use of MSCs for liver cirrhosis models, while a number of clinical studies have used autologous and allogeneic MSCs; however, there are only a few reports on the obvious substantial effect of MSCs in clinical studies. Since then, studies have analyzed and identified the important signals or components in MSCs that regulate immune cells, such as macrophages, under cirrhotic conditions and have revealed that MSC-derived exosomes are key regulators. Researchers are still seeking the best approach and filling the gap between basic and clinical studies to treat liver cirrhosis. This paper highlights the timeline of basic and clinical studies analyzing ABMi and MSC therapies for cirrhosis and the scope for future studies and therapy.

    DOI: 10.1186/s41232-021-00178-3

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  • Advances in the Treatment of Gastrointestinal Bleeding: Safety and Efficiency of Transnasal Endoscopy. International journal

    Hiroyuki Abe, Kenya Kamimura, Yoshihisa Arao, Junji Kohisa, Shuji Terai

    Medicines (Basel, Switzerland)   8 ( 9 )   2021.9

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    Acute upper gastrointestinal bleeding (UGIB) is a common disorder and a gastroenterological emergency. With the development of new techniques and devices, the survivability after gastrointestinal bleeding is improving. However, at the same time, we are facing the difficulty of severely complicated cases with various diseases. For example, while endoscopic examination with a normal diameter endoscope is essential for the diagnosis and treatment of UGIB, there are several cases in which it cannot be used. In these cases, transnasal endoscopy (TNE) may be a viable treatment option. This report reviews current hemostatic devices for endoscopic treatment and the safety and efficiency of using TNE in complicated cases. The latter will be demonstrated in a case report where TNE was employed in a patient with severe esophageal stenosis. This review summarizes the advances made in the devices used and will provide further ideas for the physician in terms of combining these devices and TNE.

    DOI: 10.3390/medicines8090053

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  • 【肝疾患エキスパートブック 栄養管理に活かすための最新情報】(Part 1)肝硬変 肝硬変に対する運動療法について

    上村 博輝, 寺井 崇二, 眞田 菜緒, 小師 優子

    臨床栄養   139 ( 4 )   445 - 451   2021.9

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  • 急性肝障害からの回復の予測バイオマーカーとしての血中セロトニン測定の意義

    薛 徹, 上村 顕也, 大脇 崇史, 荒生 祥尚, 横尾 健, 坂牧 僚, 上村 博輝, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   62 ( Suppl.2 )   A536 - A536   2021.9

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  • 消化器領域における再生医療の研究と新たな臨床応用 肝硬変に対する間葉系幹細胞やそのエクソソームを用いた治療法開発を目指して

    土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   62 ( Suppl.2 )   A533 - A533   2021.9

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  • 肝硬変の近未来診療 肝硬変の線維化改善を目指したHMGB1部分ペプチド療法の基礎検討と医師主導治験への展開

    土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   62 ( Suppl.2 )   A511 - A511   2021.9

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  • 【膵癌研究最前線】膵臓選択的ハイドロダイナミック遺伝子導入法

    柴田 理, 上村 顕也, 田中 裕登, 小川 光平, 阿部 寛幸, 五十嵐 聡, 横尾 健, 寺井 崇二

    消化器・肝臓内科   10 ( 3 )   342 - 346   2021.9

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  • The prognosis and incidence of hepatic encephalopathy of patients with liver cirrhosis treated with proton pump inhibitors: A multicenter retrospective study in Japan. International journal

    Akira Sakamaki, Kenya Kamimura, Takeshi Yokoo, Akihiko Osaki, Seiichi Yoshikawa, Yoshihisa Arao, Toru Setsu, Hiroteru Kamimura, Nobuo Waguri, Manabu Takeuchi, Kazuhiro Funakoshi, Shuji Terai

    Medicine   100 ( 32 )   e26902   2021.8

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    ABSTRACT: Gastrointestinal bleeding, hepatic encephalopathy (HE), and hepatocarcinogenesis are associated with the prognosis of patients with liver cirrhosis (LC). Proton pump inhibitors (PPIs) have been used to prevent bleeding, however the effects of PPIs on overall survival have not yet been elucidated. Therefore, this multicenter retrospective study aimed to assess the effect of PPI on the prognosis and HE occurrence of the patients with liver cirrhosis in Japan.A total of 456 patients diagnosed with LC at the 4 institutes during the study period (2010-2014) were assessed. PPI-treated and non-treated patients were compared using propensity score matching analysis. Primary and secondary endpoints of the study were set as the occurrence of HE and overall survival, respectively.A comparison of all cases showed a significantly poorer hepatic reserve function in the PPI-treated patients. The propensity-score matching analysis was performed and 120 PPI-treated patients were 1:1 matched with non-treated patients. The analysis revealed a higher incidence of HE in the PPI-treated than in the non-treated patients (P = .032; hazard ratio [HR], 2.162; 95% confidence interval [CI], 1.066-4.176), but the prognosis of PPI-treated patients was no worse than that of non-treated patients (P = .676; HR, 1.101; 95% CI, 0.702-1.726).This retrospective study showed that PPI administration for the patients with liver cirrhosis may partly be related to the increased incidence of HE but not worsen the patient prognosis.

    DOI: 10.1097/MD.0000000000026902

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  • A Rare Case of Ulcerative Colitis with Severe Pneumocystis jirovecii Pneumonia and Cytomegalovirus Colitis: A Case Report and Literature Review.

    Yusuke Watanabe, Kazunao Hayashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   2021.8

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    Pneumocystis jirovecii pneumonia (PJP) and cytomegalovirus (CMV) colitis are opportunistic infections that occur during immunosuppressive treatments for ulcerative colitis (UC). The prognosis of PJP and CMV colitis is very poor. We herein report a rare case of a 74-year-old UC patient with PJP and CMV colitis that was successfully treated with intensive therapy. PJP progresses rapidly, so the timing and choice of treatment are critical. Furthermore, a literature review of similar cases suggested that prophylactic therapy for opportunistic infections might be important, especially in the elderly. This case will serve as a reference for successful treatment in future cases.

    DOI: 10.2169/internalmedicine.7953-21

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  • Risk of delayed bleeding after hot snare polypectomy and endoscopic mucosal resection in the colorectum with continuation of anticoagulants. International journal

    Takamasa Kobayashi, Manabu Takeuchi, Yuki Hojo, Yui Ishii, Youhei Koseki, Yoko Kobayashi, Motoi Azumi, Yuji Kobayashi, Junji Kohisa, Seiichi Yoshikawa, Shuji Terai

    Journal of gastrointestinal oncology   12 ( 4 )   1518 - 1530   2021.8

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    Background: Current guidelines recommend the temporary discontinuation of anticoagulants before colonoscopic polypectomy, but the effect of this practice on reducing the risk of delayed bleeding after hot snare polypectomy (HSP) and endoscopic mucosal resection (EMR) remains unclear. Our aim was to assess the impact of anticoagulants on the risk of colorectal delayed bleeding after HSP and EMR, and evaluate the necessity of drug withdrawal. Methods: We reviewed the clinical data of patients with colorectal polyps using antithrombotic drugs who underwent HSP and/or EMR between January 2016 and September 2020 at Nagaoka Red Cross Hospital. After excluding antiplatelet users, patients were classified into those who continued anticoagulants [continuation group: 50 patients (93 lesions)] and those who discontinued anticoagulants [discontinuation group: 87 patients (190 lesions)]. Results: Delayed bleeding occurred in 12 lesions, and there was no significant difference in the incidence rates between the continuation and the discontinuation groups (3.2% vs. 4.7%; P=0.756). Logistic regression analysis showed that continued use of anticoagulants was not a significant risk factor for delayed bleeding compared to anticoagulant discontinuation (odds ratio, 0.670; 95% CI, 0.177-2.537; P=0.556). There was no significant difference in the incidence rate and risk of delayed bleeding, regardless of the length of the anticoagulant withdrawal period. Conclusions: Continued use of anticoagulants, compared to their discontinuation, did not increase the risk of colorectal delayed bleeding after HSP and EMR. Our results suggest that current guideline recommendations for anticoagulant withdrawal before colonoscopic polypectomy may be reconsidered. Trial Registration: UMIN000040449.

    DOI: 10.21037/jgo-21-3

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  • The promise of radiotherapy for hepatocellular carcinoma. International journal

    Kenya Kamimura, Shuji Terai

    Hepatology research : the official journal of the Japan Society of Hepatology   51 ( 8 )   837 - 838   2021.8

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  • Pyloric-gland metaplasia may be an origin of cancer and intestinal metaplasia with possible CDX2 expression. International journal

    Kazuyoshi Yagi, Atsunori Tsuchiya, Satoru Hashimoto, Taisuke Kato, Osamu Onodera, Shuji Terai

    Gastroenterology report   9 ( 4 )   370 - 373   2021.8

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    DOI: 10.1093/gastro/goaa061

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  • 門脈圧亢進症と臓器相関 心、肝、肺、腎、脾 当院における心不全に伴う肝臓への影響(Cardiac Hepatopathy)の解析

    上村 博輝, 寺井 崇二, 猪又 孝文, 三井田 秀, 山崎 文紗子, 柏村 健, 藤木 信也, 渡邊 雄介, 荒生 祥尚, 木村 成宏, 阿部 寛幸, 薛 徹, 坂牧 僚, 横尾 健

    日本門脈圧亢進症学会雑誌   27 ( 3 )   109 - 109   2021.8

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  • 急性膵炎後の膵仮性嚢胞門脈瘻による広範な門脈血栓症を発症した2例

    木村 成宏, 林 和直, 土屋 淳紀, 寺井 崇二

    日本門脈圧亢進症学会雑誌   27 ( 3 )   147 - 147   2021.8

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  • BRTO中に出血を来し、NBCAによるEISを併用し治療を完遂した十二指腸静脈瘤の1例

    前田 悠一郎, 荒生 祥尚, 小島 雄一, 川田 雄三, 渡邉 雄介, 薛 徹, 阿部 寛幸, 坂牧 僚, 上村 博輝, 横尾 健, 土屋 淳紀, 上村 顕也, 横山 純二, 寺井 崇二

    日本門脈圧亢進症学会雑誌   27 ( 3 )   134 - 134   2021.8

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  • 門脈圧亢進症を伴う肝硬変に対する薬物療法の進歩〜QOL、予後の改善を目指して〜 肝硬変に伴うサルコペニアに対する難吸収性抗菌薬の有用性についての検討

    坂牧 僚, 土屋 淳紀, 寺井 崇二

    日本門脈圧亢進症学会雑誌   27 ( 3 )   106 - 106   2021.8

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  • 潜在性肝性脳症は水素型SIBOに関連し、その治療にはリファキシミンが有効である

    坂牧 僚, 横山 邦彦, 高橋 一也, 成瀬 匠, 冨永 顕太郎, 佐藤 裕樹, 上村 顕也, 横山 純二, 寺井 崇二

    日本門脈圧亢進症学会雑誌   27 ( 3 )   176 - 176   2021.8

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  • Suppression of Noncoding RNAs as Shared Early Genetic Events in Multistep Hepatocarcinogenesis. International journal

    Takeshi Suda, Seiichi Yoshikawa, Tsutomu Kanefuji, Satoshi Abe, Takahiro Hoshi, Shinichi Morita, Kazuyoshi Yagi, Shuji Terai

    Hepatology (Baltimore, Md.)   2021.7

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    DOI: 10.1002/hep.32077

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  • A genome-wide association study identifying SVEP1 variant as a predictor of response to tolvaptan for cirrhotic ascites. International journal

    Hideto Kawaratani, Hiromi Sawai, Masaya Onishi, Tomomi Kogiso, Noritomo Shimada, Haruki Uojima, Tomoaki Nakajima, Naoki Matsumoto, Kenichi Ikejima, Toru Ishikawa, Shuji Terai, Hiroyuki Motoyama, Atsumasa Komori, Noboru Hirashima, Satoru Saito, Yuichiro Eguchi, Masanori Nojima, Yosuke Kawai, Masakuni Tateyama, Hitoshi Yoshiji, Yasuhito Tanaka

    Liver international : official journal of the International Association for the Study of the Liver   41 ( 12 )   2944 - 2953   2021.7

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    BACKGROUND & AIMS: Tolvaptan, vasopressin V2-receptor antagonist, has been used for patients with difficult-to-treat ascites in Japan. In this study, we conducted a genome-wide association study (GWAS) in the Japanese population to identify genetic variants associated with tolvaptan's efficacy for patients with hepatic ascites. METHODS: From 2014 through 2018, genomic DNA samples were obtained from 550 patients who were treated with tolvaptan. Of those, 80 cases (non-responder; increase of body weight [BW]) and 333 controls (responder; >1.5 kg decrease of BW) were included in the GWAS and replication study. RESULTS: Genome-wide association study showed 5 candidate SNPs around the miR818, KIAA1109, and SVEP1 genes. After validation and performing a replication study, an SNP (rs2991364) located in the SVEP1 gene was found to have a significant genome-wide association (OR = 3.55, P = 2.01 × 10-8 ). Multivariate analyses showed that serum sodium (Na), blood urea nitrogen (BUN) and SVEP1 SNP were significantly associated with the response (OR = 0.92, P = .003; OR = 1.02, P = .02 and OR = 3.98, P = .000008, respectively). Based on a prediction model of logistic regression analysis in a population with the rs2991364 risk allele, the failure probability (=exp (score: 22.234 + BUN*0.077 + Na*-0.179) (1 + exp (score)) was determined for the detection of non-responders. Assuming a cutoff of failure probability at 38.6%, sensitivity was 84.4%, specificity was 70% and AUC was 0.774. CONCLUSION: SVEP1 rs2991364 was identified as the specific SNP for the tolvaptan response. The prediction score (>38.6%) can identify tolvaptan non-responders and help to avoid a lengthy period of futile treatment.

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  • Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.

    Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike

    Journal of gastroenterology   56 ( 7 )   593 - 619   2021.7

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    The first edition of the clinical practice guidelines for liver cirrhosis was published in 2010, and the second edition was published in 2015 by the Japanese Society of Gastroenterology (JSGE). The revised third edition was recently published in 2020. This version has become a joint guideline by the JSGE and the Japan Society of Hepatology (JSH). In addition to the clinical questions (CQs), background questions (BQs) are new items for basic clinical knowledge, and future research questions (FRQs) are newly added clinically important items. Concerning the clinical treatment of liver cirrhosis, new findings have been reported over the past 5 years since the second edition. In this revision, we decided to match the international standards as much as possible by referring to the latest international guidelines. Newly developed agents for various complications have also made great progress. In comparison with the latest global guidelines, such as the European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases (AASLD), we are introducing data based on the evidence for clinical practice in Japan. The flowchart for nutrition therapy was reviewed to be useful for daily medical care by referring to overseas guidelines. We also explain several clinically important items that have recently received focus and were not mentioned in the last editions. This digest version describes the issues related to the management of liver cirrhosis and several complications in clinical practice. The content begins with a diagnostic algorithm, the revised flowchart for nutritional therapy, and refracted ascites, which are of great importance to patients with cirrhosis. In addition to the updated antiviral therapy for hepatitis B and C liver cirrhosis, the latest treatments for non-viral cirrhosis, such as alcoholic steatohepatitis/non-alcoholic steatohepatitis (ASH/NASH) and autoimmune-related cirrhosis, are also described. It also covers the latest evidence regarding the diagnosis and treatment of liver cirrhosis complications, namely gastrointestinal bleeding, ascites, hepatorenal syndrome and acute kidney injury, hepatic encephalopathy, portal thrombus, sarcopenia, muscle cramp, thrombocytopenia, pruritus, hepatopulmonary syndrome, portopulmonary hypertension, and vitamin D deficiency, including BQ, CQ and FRQ. Finally, this guideline covers prognosis prediction and liver transplantation, especially focusing on several new findings since the last version. Since this revision is a joint guideline by both societies, the same content is published simultaneously in the official English journal of JSGE and JSH.

    DOI: 10.1007/s00535-021-01788-x

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  • Evidence-based clinical practice guidelines for liver cirrhosis 2020. International journal

    Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike

    Hepatology research : the official journal of the Japan Society of Hepatology   51 ( 7 )   725 - 749   2021.7

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    The first edition of the clinical practice guidelines for liver cirrhosis was published in 2010, and the second edition was published in 2015 by the Japanese Society of Gastroenterology (JSGE). The revised third edition was recently published in 2020. This version has become a joint guideline by the JSGE and the Japanese Society of Hepatology (JSH). In addition to the clinical questions (CQs), background questions (BQs) are new items for basic clinical knowledge, and future research questions (FRQs) are newly added clinically important items. Concerning the clinical treatment of liver cirrhosis, new findings have been reported over the past 5 years since the second edition. In this revision, we decided to match the international standards as much as possible by referring to the latest international guidelines. Newly developed agents for various complications have also made great progress. In comparison with the latest global guidelines, such as the European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases (AASLD), we are introducing data based on the evidence for clinical practice in Japan. The flowchart for nutrition therapy was reviewed to be useful for daily medical care by referring to overseas guidelines. We also explain several clinically important items that have recently received focus and were not mentioned in the last editions. This digest version describes the issues related to the management of liver cirrhosis and several complications in clinical practice. The content begins with a diagnostic algorithm, the revised flowchart for nutritional therapy, and refracted ascites, which are of great importance to patients with cirrhosis. In addition to the updated antiviral therapy for hepatitis B and C liver cirrhosis, the latest treatments for non-viral cirrhosis, such as alcoholic steatohepatitis/non-alcoholic steatohepatitis (ASH/NASH) and autoimmune-related cirrhosis, are also described. It also covers the latest evidence regarding the diagnosis and treatment of liver cirrhosis complications, namely gastrointestinal bleeding, ascites, hepatorenal syndrome and acute kidney injury, hepatic encephalopathy, portal thrombus, sarcopenia, muscle cramp, thrombocytopenia, pruritus, hepatopulmonary syndrome, portopulmonary hypertension, and vitamin D deficiency, including BQ, CQ and FRQ. Finally, this guideline covers prognosis prediction and liver transplantation, especially focusing on several new findings since the last version. Since this revision is a joint guideline by both societies, the same content is published simultaneously in the official English journal of JSGE and JSH.

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  • Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea. International journal

    Haruka Hirono, Kazuhiko Watanabe, Katsuhiko Hasegawa, Masaki Kohno, Shuji Terai, Shogo Ohkoshi

    World journal of clinical cases   9 ( 19 )   5112 - 5125   2021.7

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    BACKGROUND: Obstructive sleep apnea (OSA) has been suggested as an independent risk factor for nonalcoholic fatty liver disease (NAFLD), and continuous positive airway pressure (CPAP) is the first-line therapy for OSA. AIM: To clarify the efficacy of effective CPAP therapy on NAFLD of OSA patients by serum markers and transient elastography (TE) using FibroScan® (Echosens, Paris, France). METHODS: We prospectively enrolled 123 consecutive patients with OSA who met the indications for CPAP. Liver fibrosis and steatosis were assessed using TE. Before and after 6 mo of CPAP therapy, serum markers and TE were assessed for all patients. The mean usage rate of CPAP therapy for 6 mo was arbitrarily calculated in each patient and expressed as "mean compliance index" (m-CI). RESULTS: In 50 OSA patients with NAFLD, both aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly decreased after 6 mo of CPAP therapy. Univariate analysis showed that decreased body weight (BW), decreased body mass index (BMI), decreased AST level, decreased hemoglobin A1c, and high m-CI were significantly related with improved ALT level. In multivariate regression model adjusted for quantities of BW change during 6 mo of CPAP therapy, high m-CI tended to improve ALT level (P = 0.051). All 17 OSA patients with NAFLD, high m-CI and no BMI changes showed significant improvements in AST and ALT levels. Meanwhile, no significant changes in TE data or serum fibrosis markers were seen. CONCLUSION: Some NAFLD could be associated with chronic intermittent hypoxia due to OSA independent of BW changes. In those cases, adequate reoxygenation from effective CPAP therapy may improve NAFLD.

    DOI: 10.12998/wjcc.v9.i19.5112

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  • Biliary Obstruction Caused by B-Cell Lymphoma Associated With IgG4-Related Disease. International journal

    Kazuya Ogawa, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Shuji Terai

    The American journal of gastroenterology   2021.7

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    DOI: 10.14309/ajg.0000000000001367

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  • Tuberculous Spondylitis in a Woman without Pulmonary Lesions.

    Shinichi Morita, Toshinori Takada, Kazumasa Ohashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   60 ( 13 )   2157 - 2158   2021.7

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    DOI: 10.2169/internalmedicine.5054-20

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  • 当院における腹腔鏡・内視鏡合同手術(LECS)の現状と課題

    加納 陽介, 羽入 隆晃, 佐藤 裕樹, 水野 研一, 市川 寛, 石川 卓, 宗岡 悠介, 茂木 大輔, 須藤 翔, 小柳 英人, 三浦 宏平, 滝沢 一泰, 中野 雅人, 島田 能史, 永橋 昌幸, 坂田 純, 寺井 崇二, 若井 俊文

    ENDOSCOPIC FORUM for digestive disease   37 ( 1 )   36 - 36   2021.7

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  • Rapid decline in visceral adipose tissue over 1 month is associated with poor prognosis in patients with unresectable pancreatic cancer. International journal

    Oki Nakano, Hirokazu Kawai, Takamasa Kobayashi, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    Cancer medicine   10 ( 13 )   4291 - 4301   2021.7

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    BACKGROUND: Involuntary weight loss related to cachexia is common in patients with advanced cancer, but the association between body composition changes and survival is still unclear in pancreatic cancer. METHODS: We retrospectively reviewed the clinical outcomes of 55 patients with advanced pancreatic cancer undergoing palliative therapy or best supportive care (BSC). The skeletal muscle index (SMI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and visceral to subcutaneous adipose tissue area ratio (VSR) were calculated based on the cross-sectional area on two sets of computed tomography images obtained at cancer diagnosis and 1 month later before treatment. The prognostic value of body composition indexes at diagnosis and the changes in those indexes over 1 month was then evaluated. RESULTS: In total, 45 patients (81.8%) received chemotherapy, chemoradiation, or radiation therapy, whereas the remaining patients underwent BSC. There were 27 patients (49.1%) who had low SMI at cancer diagnosis. Univariate analysis showed no significant associations between the baseline body composition indexes including SMI, VATI, SATI, and VSR and survival. Meanwhile, male sex (HR, 2.79; 95% CI, 1.16-6.71, p = 0.022) and higher decrease in VATI over 1 month (HR, 2.41; 95% CI, 1.13-5.13, p = 0.023) were identified as independent risk factors for mortality in multivariate analysis. CONCLUSION: Rapid decline in VAT over 1 month is closely associated with poorer survival in unresectable advanced pancreatic cancer. A short-term assessment of body composition changes may be a rational approach to predict prognosis in these patients.

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  • Rapid Onset of Weight Gain and Liver Dysfunction Successfully Treated With Nutrition and Exercise. International journal

    Hiroteru Kamimura, Masakazu Sano, Takanori Tsujimura, Yasunaga Takeda, Yuko Komoro, Junji Yokoyama, Shuji Terai

    Cureus   13 ( 7 )   e16530   2021.7

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    Physical inactivity is one of the causes of most metabolic syndromes. The incidence of metabolic syndrome is expected to increase in the near future because of the reduced opportunities for exercise caused by COVID-19. Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease. Changes in diet and lifestyle have led to a dramatic increase in the prevalence of NAFLD in the world. NAFLD is characterized by excessive triglyceride (TG) accumulation in the hepatocytes due to both increased inflow of free fatty acids and de novo hepatic lipogenesis. Thus far, no study quantitatively assessed the liver fat deposition after a rapid decline in physical activity. Herein, we describe a case of a 17-year-old Japanese boy with severe fat infiltration of the liver, due to a rapid decline in physical activity, treated at our facility. Our rehabilitation and nutritional support teams administered appropriate exercise and nutrition support to reduce weight and improve liver dysfunction. Our findings support dietary changes and exercise therapy to manage such cases.

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  • 被包化膵壊死への真菌感染による敗血症性ショックをきたした一例

    山田 麻理奈[大越], 上村 顕也, 石川 夏生, 小関 洋平, 田中 裕登, 水澤 健, 佐藤 裕樹, 五十嵐 聡, 林 和直, 坂牧 僚, 横山 純二, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   37 ( 1 )   30 - 30   2021.7

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  • 高齢者消化器がん化学療法〜高齢者のがん治療を安全・効果的に遂行するための取り組み 高齢肝細胞癌症例における分子標的治療薬の生存期間延長効果と予測因子の検討

    横尾 健, 酒井 規裕, 渡邉 雄介, 荒生 祥尚, 木村 成宏, 阿部 寛幸, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    日本高齢消化器病学会誌   24 ( 1 )   115 - 115   2021.7

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  • 自己免疫性膵炎と膵癌との鑑別の現状と課題

    小川 光平, 林 和直, 五十嵐 聡, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   37 ( 1 )   32 - 32   2021.7

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  • Shrinkage of a Submucosal Tumor in the Rectum. International journal

    Takamasa Kobayashi, Manabu Takeuchi, Shuji Terai

    Journal of gastrointestinal and liver diseases : JGLD   30 ( 2 )   183 - 184   2021.6

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    DOI: 10.15403/jgld-3437

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  • Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma. International journal

    Takeki Sato, Atsunori Tsuchiya, Takashi Owaki, Masaru Kumagai, Satoko Motegi, Takahiro Iwasawa, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yusuke Watanabe, Yuzo Kawata, Hiroteru Kamimura, Shuji Terai

    Biochemical and biophysical research communications   566   36 - 44   2021.6

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    The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. The melanocortin 4 receptor-deficient (Mc4r-KO) mice were divided into four groups with or without a high-fat diet (HFD) and with or without dextran sulfate sodium (DSS) to induce colitis, and the differences in liver damage and occurrence of HCC were analyzed. In the HFD + DSS group, the body weight, liver weight/body weight ratio, and serum levels of albumin and alanine aminotransferase were significantly lower than those in the HFD group. We further found that steatosis was significantly lower and lobular inflammation was significantly higher in the HFD + DSS group than those in the HFD group, and that individual steatosis and lobular inflammation state in the HFD + DSS mice varied. We detected HCC only in the HFD + DSS group, and mice with severe steatosis and mild colitis were found to be at high risk of HCC. Presently, the prediction of HCC is very difficult. In some cases, severe colitis reverses the fat accumulation due to appetite loss. Our findings clearly showed that severe steatohepatitis and mild colitis are simultaneously essential for the occurrence of HCC in patients with NASH and IBD.

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  • Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature.

    Osamu Shibata, Kenya Kamimura, Masayoshi Ko, Norihiro Sakai, Hiroyuki Abe, Shinichi Morita, Takeshi Mizusawa, Hiroki Sato, Akira Sakamaki, Shuji Terai

    Internal medicine (Tokyo, Japan)   60 ( 11 )   1709 - 1715   2021.6

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    Basic and clinical research have shown that the expression of molecules involved in the hepatocellular carcinoma (HCC) cell signaling pathway is related to the sensitivity to molecular-targeted agents. We herein report a case of HCC that was effectively treated with lenvatinib after a poor response to sorafenib. The tumor showed a high expression of fibroblast growth factor receptor 4, which is reportedly related to the sensitivity to lenvatinib in vitro. The information obtained from this case and from our literature review highlights the importance of assessing the expression of the molecules involved in tumors for effective precision medicine.

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  • A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype. International journal

    Masafumi Takatsuna, Rie Azumi, Takeshi Mizusawa, Hiroki Sato, Ken-Ichi Mizuno, Takashi Kato, Junji Yokoyama, Yoichi Ajioka, Shuji Terai

    Endoscopy international open   9 ( 6 )   E863-E866   2021.6

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    A 40-year-old man with slightly depressed (0-IIc) type gastric cancer of the pyloric anterior gastric area underwent pre-operative screening for tetralogy of Fallot and endoscopic submucosal dissection (ESD) and was tested for Helicobacter pylori antigens and antibodies. Both tests were negative. He did not have a history of eradication. Pathological diagnosis of ESD showed a well-differentiated adenocarcinoma. The tumor was CD10-positive, MUC5AC-negative, and MUC6-confocal positive; it showed differentiation with gastrointestinal phenotype. Moreover, the tumor cells were lysozyme-positive, resembling Paneth cells. Mucosal glands exhibited intestinal metaplasia on the anal side of the tumor lesion. On the oral side of the tumor, metaplasia was non-existent, with normal pyloric glands present in the mucosal layer. The patient was not infected with H. pylori ; however, intestinal metaplasia existed around the early gastric cancer. This suggested that the intestinal metaplasia occurred due to bile reflux, and the gastric neoplasia arose with the metaplasia without an H. pylori infection. This case may potentially help explain gastric cancer development in the absence of H. pylori infection.

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  • Transoral surgery for superficial head and neck cancer: National Multi-Center Survey in Japan. International journal

    Chikatoshi Katada, Manabu Muto, Satoshi Fujii, Tetsuji Yokoyama, Tomonori Yano, Akihito Watanabe, Toshiro Iizuka, Shigetaka Yoshinaga, Ichiro Tateya, Hiroki Mitani, Yuichi Shimizu, Akiko Takahashi, Tomoyuki Kamijo, Noboru Hanaoka, Makoto Abe, Akihiro Shiotani, Koichi Kano, Yukinori Asada, Tamotsu Matsuhashi, Hirohito Umeno, Kenji Okami, Kenichi Goda, Shinichiro Hori, Yoichiro Ono, Shuji Terai, Yasuaki Nagami, Kenichi Takemura, Kenro Kawada, Mizuo Ando, Naoto Shimeno, Akihito Arai, Yasutoshi Sakamoto, Masaaki Ichinoe, Tetsuo Nemoto, Masahiro Fujita, Hidenobu Watanabe, Tadakazu Shimoda, Atsushi Ochiai, Takakuni Kato, Ryuichi Hayashi

    Cancer medicine   10 ( 12 )   3848 - 3861   2021.6

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    Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real-world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1-75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2-357). Adverse events occurred in 12.7%. Life-threatening complications occurred in 0.5%, but there were no treatment-related deaths. During a median follow-up period of 46.1 months (range 1-113), the 3-year overall survival rate, relapse-free survival rate, cause-specific survival rate, and larynx-preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment. Clinical trials registry number: UMIN000008276.

    DOI: 10.1002/cam4.3927

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  • 併存する疾患のあることが多い高齢者における上部消化管疾患のマネージメント 地域病院における消化器サルコペニア疾患診療の有用性

    上村 博輝, 小島 雄一, 高橋 一也, 高綱 将史, 平野 正明, 政二 文明, 藤田 一, 辻村 恭憲, 小林 太一, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   68回   52 - 52   2021.6

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  • 感染性被包化と壊死門脈瘻を伴う膵仮性嚢胞の一例(A case of pancreatic pseudocyst-portal vein fistula with infected walled off necrosis)

    前田 悠一郎, 林 和直, 戸田 遼, 若林 拓哉, 木村 究, 水戸 將貴, 小島 雄一, 小川 光平, 荒生 祥尚, 木村 成宏, 五十嵐 聡, 土屋 淳紀, 徳永 麻美, 佐藤 知巳, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   68回   35 - 35   2021.6

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  • Effectiveness of EUS-Guided Fine-Needle Biopsy versus EUS-Guided Fine-Needle Aspiration: A Retrospective Analysis. International journal

    Naosuke Kuraoka, Satoru Hashimoto, Shigeru Matsui, Shuji Terai

    Diagnostics (Basel, Switzerland)   11 ( 6 )   2021.5

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    Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for pancreatic tumors and subepithelial lesions (SEL) of the gastrointestinal tract are effective for histological diagnosis. There are also reports that tissue sampling is possible with a smaller number of punctures by EUS-guided fine-needle biopsy (EUS-FNB). In this study, we retrospectively compared the diagnostic abilities of EUS-FNA and EUS-FNB. We examined 130 patients who underwent EUS-FNA/EUS-FNB for pancreatic tumors and SEL from July 2018 to January 2021. None of the cases underwent rapid on-site evaluation. There were 94 and 36 cases in the EUS-FNA and EUS-FNB groups, respectively. The median tumor size in the EUS-FNB group was 30 mm, which was significantly larger than the EUS-FNA group (p = 0.02). In addition, transgastric puncture was significantly more common in the EUS-FNB group (p = 0.01). The EUS-FNA and EUS-FNB groups had a sensitivity of 82.9% and 91.7% and an accuracy rate of 85.1% and 91.7%, respectively. However, both procedures had a comparable diagnostic ability.

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  • Long-term survival of 11 years with multidisciplinary therapy for hepatocellular carcinoma metastasis to the ovary and peritoneum: a case report.

    Satoko Motegi, Takeshi Yokoo, Ryosuke Nozawa, Rie Azumi, Yuzo Kawata, Kohei Ogawa, Toru Setsu, Ken-Ichi Mizuno, Koji Nishino, Hajime Umezu, Hirokazu Kawai, Takeshi Suda, Shuji Terai

    Clinical journal of gastroenterology   14 ( 4 )   1211 - 1220   2021.5

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    We herein report a rare case of HCC metastases to the ovary and peritoneum in a 61-year-old female patient who has achieved 11-year survival with multidisciplinary therapy. The patient was diagnosed with HCC during balloon angioplasty performed for Budd-Chiari syndrome in 1994 and underwent partial hepatectomy twice. Five years after the second hepatectomy, allochronic recurrence of a single nodule detected in S8 was treated by radiofrequency ablation, followed by percutaneous ethanol injection therapy and stereotactic body radiotherapy. However, her α-fetoprotein level rose to 1862 ng/mL within one year and computed tomography revealed a large pelvic tumor suggesting HCC metastasis to the ovary. The subsequent laparotomy revealed one 11-cm left ovarian tumor, one small right ovarian nodule, and numerous peritoneal nodules. Bilateral salpingo-oophorectomy and peritoneal resection of as many nodules as possible were performed. Combination therapy with intravenous 5-fluorouracil plus cisplatin and ramucirumab monotherapy effectively suppressed tumor progression with maintenance of hepatic functional reserve, and she has achieved long-term survival of 11 years, illustrating that multidisciplinary therapy with favorable hepatic functional reserve maintenance can contribute to long-term survival in HCC with extrahepatic spread.

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  • Endoscopic retrieval of multiple sewing needles by using the tip of a magnetic tube. International journal

    Shinichi Morita, Kazuyoshi Yagi, Takahiro Hoshi, Satoshi Abe, Shuji Terai

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy   6 ( 5 )   228 - 230   2021.5

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    Video 1Multiple sewing needles are retrieved from the stomach endoscopically using the tip of a magnet tube.

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  • The first case of balloon-occluded retrograde transvenous obliteration and partial splenic embolization for gastric varices in situs inversus abdominus.

    Yusuke Watanabe, Akihiko Osaki, Nobuo Waguri, Shuji Terai

    Clinical journal of gastroenterology   14 ( 2 )   656 - 661   2021.4

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    Situs inversus abdominus is a congenital abnormality characterized by the mirror image positioning of the abdominal organs, making it difficult to diagnosis and treatment of many diseases. Here, we report a rare case of gastric varices in situs inversus abdominus patient. A 55-year-old man was diagnosed with F2-shaped gastric varices associated with alcoholic cirrhosis. Abdominal dynamic computed tomography showed situs inversus abdominus, and gastric varices with a gastrorenal shunt. Due to the complex anatomy, emergency interventional radiology during bleeding was extremely difficult. Therefore, after thorough consultation, we decided to treat gastric varices prophylactically by balloon-occluded retrograde transvenous obliteration. After treatment, the patient's clinical course was generally good, with no adverse events, and the gastric varices disappeared. It is important to assess anatomical positioning using three-dimensional reconstruction computed tomography images before treatment, to adequately prepare, including selecting appropriate devices (i.e., catheters and sheath). Although preventive treatment of gastric varices is controversial, in cases with anatomical complexity, preventive treatment with sufficient preparation would be recommended. To the best of our knowledge, there are no reports of treatment for gastric varices in situs inversus abdominus patient. This case will serve as a reference for successful treatment in future cases.

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  • Paris II and Rotterdam criteria are the best predictors of outcomes in patients with primary biliary cholangitis in Japan. International journal

    Naruhiro Kimura, Masaaki Takamura, Nobutaka Takeda, Yusuke Watanabe, Yoshihisa Arao, Masahumi Takatsuna, Suguru Takeuchi, Hiroyuki Abe, Toru Setsu, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    Hepatology international   15 ( 2 )   437 - 443   2021.4

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    BACKGROUND: Biochemical response to treatment in patients with primary biliary cholangitis (PBC) reflects prognosis. However, the best predictive criteria to detect biochemical response remain undetermined. In addition, because these criteria need > 6 months until definition, parameters that can estimate its results before initiating treatment are needed. METHODS: We conducted a single-center retrospective study on 196 patients with PBC, followed up for at least 12 months after initiating treatment. RESULTS: Kaplan-Meier analysis showed that Paris II (p = 0.002) and Rotterdam criteria (p = 0.001) could estimate the overall survival of PBC patients, whereas Paris II (p = 0.001), Rotterdam (p = 0.001), and Rochester criteria (p= 0.025) could estimate liver-related deaths. Cox hazard analysis revealed Paris II and Rotterdam criteria as significantly independent predictors of overall survival (hazard ratio (HR) 3.948, 95% CI 1.293-12.054, p = 0.016 and HR 6.040, 95% CI 1.969-18.527, p = 0.002, respectively) and liver-related deaths (HR 10.461, 95% CI 1.231-88.936, p = 0.032 and HR 10.824, 95% CI 1.252-93.572, p = 0.032, respectively). The results of Paris II criteria could be estimated by serum prothrombin time (Odds ratio (OR) 1.052, 95% CI 1.008-1.098, p = 0.021) and alanine transaminase level (OR 0.954, 95% CI 0.919-0.991, p = 0.014) whereas, those of Rotterdam criteria could be estimated by serum albumin level (OR 3.649, 95% CI 1.098-12.128, p = 0.035) at the time of diagnosis. CONCLUSIONS: This study highlights the best prediction criteria and pre-treatment parameters that facilitate the prognosis of PBC patients.

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  • Analysis of the safety of pretransplant corticosteroid therapy in patients with acute liver failure and late-onset hepatic failure in Japan. International journal

    Takuro Hisanaga, Isao Hidaka, Isao Sakaida, Nobuaki Nakayama, Akio Ido, Naoya Kato, Yasuhiro Takikawa, Kazuaki Inoue, Masahito Shimizu, Takuya Genda, Shuji Terai, Hirohito Tsubouchi, Hajime Takikawa, Satoshi Mochida, Intractable Hepato-Biliary Disease Study Group Of Japan

    JGH open : an open access journal of gastroenterology and hepatology   5 ( 4 )   428 - 433   2021.4

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    Background and Aim: In Japan, corticosteroids have been commonly used as a part of multidisciplinary therapy for patients with acute liver failure and late-onset hepatic failure. However, there is controversy regarding the development of infections and other complications. In this study, the influence of corticosteroids on patient outcomes after liver transplantation was investigated. Methods: This study included 167 patients with acute liver failure and late-onset hepatic failure who underwent liver transplantation between 2010 and 2015. The effects of pretransplant corticosteroid therapy on patient outcomes were evaluated using a database constructed by the subcommittee for fulminant hepatitis in the Intractable Hepato-Biliary Diseases Study Group of Japan. Results: The subacute type and the median total bilirubin levels were higher in those receiving corticosteroids than in those not receiving corticosteroids. Although infections tended to be higher in patients receiving corticosteroids, pretransplant corticosteroid administration did not affect the survival rates. The duration from corticosteroid initiation to liver transplantation was longer in patients who developed infections. The survival rates, however, did not differ between patients with and without infections. Conclusions: Corticosteroids were administered to patients with poor prognoses. Otherwise, the overall outcome in those administered corticosteroids was not significantly different from that in those administered without corticosteroids. Although infectious complications tended to occur, they were generally controllable and nonfatal. Pretransplant corticosteroid therapy may be permissible, with regarding for infections and performed within the minimum duration.

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  • Achalasia and esophageal cancer: a large database analysis in Japan.

    Hiroki Sato, Shuji Terai, Yuto Shimamura, Shinwa Tanaka, Hironari Shiwaku, Hitomi Minami, Chiaki Sato, Ryo Ogawa, Hiroshi Yokomichi, Haruhiro Inoue

    Journal of gastroenterology   56 ( 4 )   360 - 370   2021.4

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    BACKGROUND: Achalasia has been reported to be associated with esophageal cancers (ECs). However, owing to the rarity of achalasia, details of achalasia-related ECs are not well investigated. METHOD: The incidence of ECs in Japanese patients with achalasia and achalasia-related esophageal motility disorders (EMDs) was estimated, and risk factors for achalasia-related ECs were determined. Characteristics of ECs and treatment courses were also analyzed. RESULTS: Between 2010 and 2019, 2714 Japanese patients with achalasia and achalasia-related EMDs were recorded in 7 high-volume centers; 24 patients (21 men, 3 women) developed ECs. The incidence of ECs was estimated at 0.078 and 0.28 per 100 person-years from the onset and the diagnosis of disease, respectively. Kaplan-Meier estimate suggested that, in addition to a long history of achalasia, advanced age, male sex, and regular alcohol consumption were statistically significant risk factors for EC development. A prevalence of 40 ECs (12.5% multiple lesions, and 22.7% metachronal lesions) was also noted, predominantly distributed over the thoracic esophagus. All were histologically diagnosed as squamous cell carcinoma. Superficial ECs were successfully treated with endoscopic treatment in all cases, except one. Achalasia-related Barret esophagus was extremely rare, and Barret adenocarcinoma was not detected in our cohort. CONCLUSION: The high relative risk of ECs was clarified in Japanese achalasia patients, although the absolute risk remained low. Therefore, surveillance endoscopy may be recommended in limited patients with several aforementioned risk factors determined. Superficial cancer can be treated with endoscopic treatment. Multiple and metachronal ECs should be screened.

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  • 当センターでの肝炎医療コーディネーター養成の現状と院内非専門医対策について

    薛 徹, 荒生 祥尚, 廣川 光, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A242 - A242   2021.4

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  • 新潟県における自治体肝炎ウイルス検診の現状

    薛 徹, 菊田 玲, 中島 徹, 荒生 祥尚, 中山 均, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A230 - A230   2021.4

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  • 当センターでの肝炎医療コーディネーター養成の現状と院内非専門医対策について

    薛 徹, 荒生 祥尚, 廣川 光, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A242 - A242   2021.4

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  • 新潟県における自治体肝炎ウイルス検診の現状

    薛 徹, 菊田 玲, 中島 徹, 荒生 祥尚, 中山 均, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A230 - A230   2021.4

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  • 臨床応用を目指したバイオマーカー研究の最前線 急性肝障害条件下での血中セロトニン量の病態・予後予測バイオマーカーとしての有用性の検討

    薛 徹, 上村 顕也, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A170 - A170   2021.4

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  • 肝移植の現状と課題 当県での肝障害症例を対象としたネットワークの運用と、アンケート調査からみた県内の肝障害診療の現状と今後の啓発の必要性

    薛 徹, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A113 - A113   2021.4

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  • 肝疾患におけるビックデータとAI(人工知能)の臨床応用 ディープラーニングを活用したPBC多施設データから予測する高齢者PBCの介入の必要性の検討

    上村 博輝, 高村 昌昭, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A208 - A208   2021.4

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  • 肝疾患移行期医療の現状と問題点 先天性心疾患術後に肝線維化悪化に影響を及ぼす因子の解析

    山崎 文紗子, 上村 博輝, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A167 - A167   2021.4

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  • 多発肝転移、リンパ節転移を伴う直腸原発神経内分泌腫瘍に対して集学的治療が有効であった一例 当院での症例群の検討と共に

    小川 和也, 阿部 寛幸, 上村 顕也, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A266 - A266   2021.4

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  • point shear wave elastographyを利用した肝線維化のheterogeneityの検証

    横尾 健, 杉田 萌乃, 荒生 祥尚, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    超音波医学   48 ( Suppl. )   S713 - S713   2021.4

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  • 肝再生の可能性と障壁 HMGB1の部分ペプチドを用いた慢性肝疾患に対するセルフリー治療の開発

    土屋 淳紀, 野尻 俊介, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A69 - A69   2021.4

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  • 【肝類洞壁細胞研究における新知見】肝の炎症、線維化と類洞壁細胞 間葉系幹細胞を用いた新規治療法の開発

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    肝胆膵   82 ( 4 )   525 - 529   2021.4

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  • 肝癌に対する局所療法としての放射線療法の安全性と有効性の検証

    山田 麻理奈, 上村 顕也, 柴田 理, 森田 真一, 寺井 崇二

    肝臓   62 ( Suppl.1 )   A338 - A338   2021.4

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  • Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis. International journal

    Suguru Takeuchi, Atsunori Tsuchiya, Takahiro Iwasawa, Shunsuke Nojiri, Takayuki Watanabe, Masahiro Ogawa, Tomoaki Yoshida, Katsunori Fujiki, Yuta Koui, Taketomo Kido, Yusuke Yoshioka, Mayu Fujita, Junichi Kikuta, Tohru Itoh, Masaaki Takamura, Katsuhiko Shirahige, Masaru Ishii, Takahiro Ochiya, Atsushi Miyajima, Shuji Terai

    NPJ Regenerative medicine   6 ( 1 )   19 - 19   2021.3

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    Mesenchymal stromal cells (MSCs) are used for ameliorating liver fibrosis and aiding liver regeneration after cirrhosis; Here, we analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned MSCs (γ-sEVs). γ-sEVs effectively induced anti-inflammatory macrophages with high motility and phagocytic abilities in vitro, while not preventing hepatic stellate cell (HSC; the major source of collagen fiber) activation in vitro. The proteome analysis of MSC-derived sEVs revealed anti-inflammatory macrophage inducible proteins (e.g., annexin-A1, lactotransferrin, and aminopeptidase N) upon IFN-γ stimulation. Furthermore, by enabling CX3CR1+ macrophage accumulation in the damaged area, γ-sEVs ameliorated inflammation and fibrosis in the cirrhosis mouse model more effectively than sEVs. Single cell RNA-Seq analysis revealed diverse effects, such as induction of anti-inflammatory macrophages and regulatory T cells, in the cirrhotic liver after γ-sEV administration. Overall, IFN-γ pre-conditioning altered sEVs resulted in efficient tissue repair indicating a new therapeutic strategy.

    DOI: 10.1038/s41536-021-00132-4

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  • Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver. International journal

    Masayoshi Ko, Kenya Kamimura, Takashi Owaki, Takuro Nagoya, Norihiro Sakai, Itsuo Nagayama, Yusuke Niwa, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Ryosuke Inoue, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Shuji Terai

    Disease models & mechanisms   14 ( 3 )   2021.3

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    The etiology of non-alcoholic fatty liver disease (NAFLD) consists of various factors, including neural signal pathways. However, the molecular mechanisms of the autonomic neural signals influencing NAFLD progression have not been elucidated. Therefore, we examined the involvement of the gut-liver neural axis in NAFLD development and tested the therapeutic effect of modulation of this axis in this study. To test the contribution of the gut-liver neural axis, we examined NAFLD progression with respect to body weight, hepatic steatosis, fibrosis, intestinal tight junction, microbiota and short-chain fatty acids in NAFLD models of choline-deficient defined L-amino-acid and high-fat diet-fed mice with or without blockades of autonomic nerves from the liver. Blockade of the neural signal from the liver to the gut in these NAFLD mice models ameliorated the progression of liver weight, hepatic steatosis and fibrosis by modulating serotonin expression in the small intestine. It was related to the severity of the liver pathology, the tight junction protein expression, microbiota diversity and short-chain fatty acids. These effects were reproduced by administrating serotonin antagonist, which ameliorated the NAFLD progression in the NAFLD mice models. Our study demonstrated that the gut-liver neural axis is involved in the etiologies of NAFLD progression and that serotonin expression through this signaling network is the key factor of this axis. Therefore, modulation of the gut-liver neural axis and serotonin antagonist ameliorates fatty and fibrotic changes in non-alcoholic fatty liver, and can be a potential therapeutic target of NAFLD.This article has an associated First Person interview with the first author of the paper.

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  • Successful treatment of positive-sense RNA virus coinfection with autoimmune hepatitis using double filtration plasmapheresis. International journal

    Hiroteru Kamimura, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    BMJ case reports   14 ( 3 )   2021.3

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    Double filtration plasmapheresis (DFPP) is an apheretic technique that selectively removes high molecular weight substances using a plasma component filter. DFPP has been used to treat positive-sense RNA virus infections, mainly chronic hepatitis C virus (HCV) infection, because of its ability to directly eliminate viral particles from blood plasma from 2008 to about 2015, before direct-acting antiviral agents was marketed. This effect has been termed virus removal and eradication by DFPP. HCV is a positive-sense RNA virus similar to West Nile virus, dengue virus and the SARS and Middle East respiratory syndrome coronaviruses. SARS-CoV-2 is classified same viral species. These viruses are all classified in Family Flaviviridae which are family of single-stranded plus-stranded RNA viruses. Viral particles are 40-60 nm in diameter, enveloped and spherical in shape. We present a rare case of HCV removal where an RNA virus infection that copresented with virus-associated autoimmune hepatitis was eliminated using DFPP. Our results indicate that DFPP may facilitate prompt viraemia reduction and may have novel treatment applications for SARS-CoV-2, that is, use of therapeutic plasma exchange for fulminant COVID-19.

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  • Adipose most abundant 2 protein is a predictive marker for cisplatin sensitivity in cancers. International journal

    Kenya Kamimura, Takeshi Suda, Yasuo Fukuhara, Shujiro Okuda, Yu Watanabe, Takeshi Yokoo, Akihiko Osaki, Nobuo Waguri, Toru Ishikawa, Toshihiro Sato, Yutaka Aoyagi, Masaaki Takamura, Toshifumi Wakai, Shuji Terai

    Scientific reports   11 ( 1 )   6255 - 6255   2021.3

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    Cisplatin (CDDP) is one of the chemotherapeutic drugs being used to treat various cancers. Although effective in many cases, as high doses of CDDP cause cytotoxic effects that may worsen patients' condition, therefore, a marker of sensitivity to CDDP is necessary to enhance the safety and efficiency of CDDP administration. This study focused on adipose most abundant 2 (APM2) to examine its potential as a marker of CDDP sensitivity. The relationship of APM2 expression with the mechanisms of CDDP resistance was examined in vitro and in vivo using hepatocellular carcinoma (HCC) cells, tissues and serum of HCC patients (n = 71) treated initially with intrahepatic arterial infusion of CDDP followed by surgical resection. The predictability of serum APM2 for CDDP sensitivity was assessed in additional 54 HCC patients and 14 gastric cancer (GC) patients. APM2 expression in CDDP-resistant HCC was significantly higher both in serum and the tissue. Bioinformatic analyses and histological analyses demonstrated upregulation of ERCC6L (DNA excision repair protein ERCC6-like) by APM2, which accounts for the degree of APM2 expression. The serum APM2 level and chemosensitivity for CDDP were assessed and cut-off value of serum APM2 for predicting the sensitivity to CDDP was determined to be 18.7 µg/mL. The value was assessed in HCC (n = 54) and GC (n = 14) patients for its predictability of CDDP sensitivity, resulted in predictive value of 77.3% and 100%, respectively. Our study demonstrated that APM2 expression is related to CDDP sensitivity and serum APM2 can be an effective biomarker of HCC and GC for determining the sensitivity to CDDP.Trial registration: This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000028487).

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  • Comorbidities and healthcare costs and resource use of patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) in the Japan medical data vision database.

    Shuji Terai, Amy Buchanan-Hughes, Alvin Ng, I-Heng Lee, Ken Hasegawa

    Journal of gastroenterology   56 ( 3 )   274 - 284   2021.3

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    BACKGROUND: This study examined demographics, comorbidities and healthcare resource use (HCRU) and costs among Japanese patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). METHODS: We conducted a repeated cross-sectional analysis of the Medical Data Vision (MDV) claims database, from January 2011 to March 2018. Demographics were described at index date and by calendar year; a "NASH" subpopulation included patients with ≥ 1 claim for NASH at any time. Prevalence of pre-specified comorbidities of interest and data-emergent top comorbidities were estimated. All-cause HCRU and costs were quantified by calendar year. Outcomes were compared between 2011 and 2017 using partially overlapping t tests. RESULTS: 58,958 patients (mean age 61.6 years; 55.5% male) were included. 1139 patients (2%) were in the NASH subpopulation. At baseline, comorbid cardiovascular disease (69.4%), diabetes (62.1%) and hyperlipidaemia (54.4%) were most prevalent; comorbidity prevalence increased with age. Mean outpatient visits decreased from 9.36 per patient in 2011 to 7.80 in 2017; mean inpatient admissions increased (both p < 0.001 for 2011 vs 2017). Mean total all-cause healthcare costs ranged from \322,206 to \340,399 per patient per year between 2011 and 2017. Although total all-cause healthcare costs did not change significantly (p = 0.552), cost burden shifted from the outpatient to inpatient setting between 2011 and 2017. All-cause healthcare resource use/costs were generally higher for the NASH subgroup compared with the overall population. CONCLUSIONS: There is a high burden of disease among Japanese NAFLD/NASH patients, including a high prevalence of comorbidities which generally increase with age. Accordingly, substantial all-cause HCRU and costs were incurred.

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  • Relationship between detection of hepatitis B virus in saliva and periodontal disease in hepatitis B virus carriers in Japan. International journal

    Hiroteru Kamimura, Jun Watanabe, Tomoyuki Sugano, Junji Kohisa, Hiroyuki Abe, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Shogo Okoshi, Yoshinari Tanabe, Ritsuo Takagi, Hirofumi Nonaka, Shuji Terai

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   27 ( 3 )   492 - 496   2021.3

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    INTRODUCTION: Although hepatitis B virus infection is well-described, the additional risk posed by oral bleeding in individuals with chronic hepatitis B virus infection has not been determined. This study aimed to determine the quantity of hepatitis B virus in the saliva of carriers in Japan, as a means of understanding the potential risk for horizontal transmission. METHODS: Saliva samples from 48 confirmed hepatitis B virus carriers were included in the analysis. Hepatitis B virus concentrations and the presence of occult blood as periodontal disease were evaluated in each sample. RESULTS: Hepatitis B surface antigen was identified in 46 of the 48 samples (98%), with hepatitis B virus DNA identified in 19 of the 48 saliva samples (40%). Occult blood was detected in 32 (67%) samples with the prevalence increasing as a function of age (r = 0.413; P = 0.003). There was a significantly positive correlation between hepatitis B virus DNA levels in the serum and saliva specimens (r = 0.895; P < 0.001). CONCLUSIONS: Occult blood in saliva was detected in most participants. The detection of hepatitis B virus DNA correlated positively with hepatitis B virus in the serum and occult blood in the saliva. Therefore, improved care of periodontal disease among older people is important for preventing horizontal transmission of hepatitis B virus.

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  • Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis. International journal

    Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yosida, Yuzo Kawata, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Junji Yokoyama, Toshifumi Wakai, Shuji Terai

    Biochemistry and biophysics reports   25   100892 - 100892   2021.3

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    It is reported that an increase in aerobic bacteria, a lack of short-chain fatty acids (SCFAs), and immune disorders in the diverted colon are major causes of diversion colitis. However, the precise pathogenesis of this condition remains unclear. The aim of the present study was to examine the microbiota, intestinal SCFAs, and immunoglobulin A (IgA) in the diverted colon. Eight patients underwent operative procedures for colostomies. We assessed the diverted colon using endoscopy and obtained intestinal samples from the diverted colon and oral colon in these patients. We analyzed the microbiota and SCFAs of the intestinal samples. The bacterial communities were investigated using a 16S rRNA gene sequencing method. The microbiota demonstrated a change in the proportion of some species, especially Lactobacillus, which significantly decreased in the diverted colon at the genus level. We also showed that intestinal SCFA values were significantly decreased in the diverted colon. Furthermore, intestinal IgA levels were significantly increased in the diverted colon. This study was the first to show that intestinal SCFAs were significantly decreased and intestinal IgA was significantly increased in the diverted colon. Our data suggest that SCFAs affect the microbiota and may play an immunological role in diversion colitis.

    DOI: 10.1016/j.bbrep.2020.100892

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  • 当院における肝炎医療コーディネーターの取り組み・課題と今後の展望

    廣川 光, 荒生 祥尚, 薛 徹, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A266 - A266   2021.3

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  • Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan

    Ryosuke Tateishi, Takeshi Matsumura, Takeshi Okanoue, Toshihide Shima, Koji Uchino, Naoto Fujiwara, Takafumi Senokuchi, Kazuyoshi Kon, Takayoshi Sasako, Makiko Taniai, Takumi Kawaguchi, Hiroshi Inoue, Hirotaka Watada, Naoto Kubota, Hitoshi Shimano, Shuichi Kaneko, Etsuko Hashimoto, Sumio Watanabe, Goshi Shiota, Kohjiro Ueki, Kosuke Kashiwabara, Yutaka Matsuyama, Hideo Tanaka, Masato Kasuga, Eiichi Araki, Kazuhiko Koike, Yoshiyasu Karino, Shuhei Hige, Masatomo Sekiguchi, Koji Ogawa, Hideaki Miyoshi, Kyu Yong Cho, Masaru Baba, Atsushi Inoue, Kazuobu Aso, Mitsuyoshi Okada, Yasuhiro Takikawa, Kei Endo, Yasushi Ishigaki, Hirobumi Togashi, Michiaki Unno, Takanori Morikawa, Hideki Katagiri, Shojiro Sawada, Hiromasa Ohira, Atsushi Takahashi, Michio Shimabukuro, Akihiro Kudo, Naomi Tanaka, Junko Mitsuhashi, Toshifumi Tokai, Yasushi Matsuzaki, Tadashi Ikegami, Masato Imai, Kou Nishikawa, Sadao Takahashi, Sumiko Nagoshi, Kosuke Maezawa, Masafumi Matsuda, Tetsuhiro Chiba, Masayuki Yokoyama, Koutaro Yokote, Yoko Hidetaka, Mitsuhiko Moriyama, Hitomi Nakamura, Midori Fujishiro, Tadakazu Hisamatsu, Kaori Nishikawa, Toshihiko Nouchi, Yuki Sakurai, Harumi Daikoku, Michinori Murayama, Yoshinori Saigusa, Takashi Matsui, Ryosuke Tateishi, Hidenari Nagai, Takanori Mukozu, Takahisa Hirose, Masahiko Miyagi, Hiroaki Sato, Akira Mizuki, Masanori Miura, Yuzuru Sato, Rena Kaneko, Kumiko Hamano, Hiroko Kato, Kentaro Kikuchi, Yusuke Kajiyama, Makoto Chuma, Hiroko Ito, Hiroshi Yasuda, Nobuyuki Matsumoto, Yasushi Tanaka, Yoshio Nagai, Kento Imajo, Yasuo Terauchi, Yuzuru Ito, Shuji Terai, Hirohito Sone, Satoshi Matsunaga

    Journal of Gastroenterology   56 ( 3 )   261 - 273   2021.3

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    DOI: 10.1007/s00535-020-01754-z

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  • 門脈圧亢進症:診断と治療の最前線 傍食道静脈の発達の有無を指標としたEVL/EISの選択による治療成績

    薛 徹, 横山 純二, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A201 - A201   2021.3

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  • 地域病院健診時の消化器サルコペニア疾患診療の有用性

    上村 博輝, 小島 雄一, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A345 - A345   2021.3

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  • 【小児期発症慢性肝疾患における移行期医療の現状と課題-小児と成人のダイアログ-】NAFLD Pediatric fatty liver disease(PeFLD)における概説と成人との比較(肝組織学的検討を含めて) 小児と成人の相違

    上村 博輝, 山崎 文紗子, 佐藤 毅昂, 薛 徹, 土屋 淳紀, 上村 顕也, 高村 昌昭, 寺井 崇二, 長崎 啓祐, 斎藤 昭彦, 梅津 哉

    肝胆膵   82 ( 3 )   425 - 440   2021.3

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  • 消化器疾患診療におけるディープラーニングの有用性の検証

    上村 博輝, 野中 尋史, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A354 - A354   2021.3

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  • 脂肪性肝疾患:新規治療法を目指した基礎研究とトランスレーショナルリサーチ ONO-1301を用いた肝硬変に対するセルフリー治療の開発

    茂木 聡子, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A223 - A223   2021.3

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  • 消化器疾患と神経系の臓器相関 脂肪性肝疾患における自律神経系ネットワークを介したセロトニンの関与

    大脇 崇史, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A144 - A144   2021.3

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  • 肝発癌抑制を目指したB型肝炎の最新治療 肝細胞癌におけるYAPとHBx蛋白の臨床的有用性の検討

    小田 知友美, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A73 - A73   2021.3

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  • 消化器領域におけるバイオマーカーの新展開 エクソソームタンパクEps8の膵癌バイオマーカーとしての検討

    林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A151 - A151   2021.3

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  • 消化器領域における再生医療:基礎的研究の最前線 HMGB1の部分ペプチドを用いた新たな肝硬変治療開発

    土屋 淳紀, 野尻 俊介, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A132 - A132   2021.3

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  • ACLF:欧米、アジアと我が国での差異 Acute on chronic liver failureに対する肝細胞老化改善の検証

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A110 - A110   2021.3

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  • 胆膵疾患研究の最前線〜from bench to bedside, from bedside to bench〜 膵臓選択的ハイドロダイナミック遺伝子導入法による新規膵癌モデル動物の確立

    柴田 理, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A232 - A232   2021.3

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  • 消化器領域の救急医療、集中治療:急性膵炎 予後因子・CT gradeを用いた重症急性膵炎の予後・感染性被包化膵壊死合併の予測

    林 和直, 五十嵐 聡, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A251 - A251   2021.3

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  • 高齢者膵癌に対する治療の適応と限界 県全域における高齢者膵癌診療の現状 多施設後方視的研究の結果より

    五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会雑誌   118 ( 臨増総会 )   A237 - A237   2021.3

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  • Potential Effect of a Selective Peroxisome Proliferator-activated Receptor Alpha Modulator on Metabolic Dysfunction-associated Fatty Liver Disease.

    Hiroteru Kamimura, Atsushi Kimura, Shuji Terai

    Internal medicine (Tokyo, Japan)   60 ( 14 )   2165 - 2166   2021.2

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    DOI: 10.2169/internalmedicine.6906-20

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  • Rare paraneoplastic syndromes in digestive systems caused by lung cancer. International journal

    Hiroteru Kamimura, Tomohiro Iwasaki, Kazunao Hayashi, Shuji Terai

    BMJ case reports   14 ( 2 )   2021.2

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    We observed a rare case of two different digestive paraneoplastic syndromes that improved with the treatment of the neoplasms. The first syndrome was chronic intestinal pseudo-obstruction (CIPO), which is a subtype of paraneoplastic syndromes called a paraneoplastic neurological syndrome (PNS). The second was Stauffer's syndrome, which is a unique paraneoplastic syndrome characterised by non-metastatic intrahepatic cholestasis associated with neoplasms. Here, we report the case of a 55-year-old man who presented with two concurrent paraneoplastic syndromes in the digestive system. The intestinal pseudo-obstruction and elevated biliary enzyme levels improved as the lung cancer responded to chemotherapy. In this case, CIPO as a PNS led to the detection of lung cancer. To our knowledge, this is the first report of Stauffer's syndrome caused by lung adenocarcinoma.

    DOI: 10.1136/bcr-2020-240161

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  • Immunoglobulin therapy for successful management of prolonged, recurrent jaundice in a young adult male with combined immunodeficiency.

    Chiyumi Oda, Atsunori Tsuchiya, Atsushi Kimura, Kentaro Tominaga, Kazunao Hayashi, Takashi Ushiki, Hajime Umezu, Shuji Terai

    Clinical journal of gastroenterology   14 ( 4 )   1197 - 1201   2021.2

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    Jaundice may be persistent in drug-induced liver injury associated with vanishing bile duct syndrome. However, recurrent jaundice is atypical, following bile flow restoration. Here, we report a 28-year-old man with prolonged, recurrent jaundice (more than 300 days) and combined immunodeficiency (CID) of B-cells, T-cells, and natural killer (NK) cells. Hypogammaglobulinemia was observed throughout his hospitalization, and peripheral blood flow cytometry detected a few B-cells (2% of CD19 + cells and 2% of CD20 + cells). We further detected the dysfunction of T-cells and NK cells. Based on these findings, CID was diagnosed. We presumed that hypogammaglobulinemia was related to the jaundice. After regular injections of intravenous immunoglobulin (IVIG), the stool color gradually turned brown. However, the color returned to white as IgG levels decreased. The brown-to-white stool pattern was repeated with another IVIG administration, suggesting that the patient's serum immunoglobulin levels were related to the jaundice. On follow-up, IVIG was performed every two to three weeks, and his total bilirubin improved gradually. Immunoglobulin replacement therapy could be one of the treatment choices for jaundice with CID.

    DOI: 10.1007/s12328-021-01347-0

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  • Multiple Tumor-Like Fatty Changes in the Liver Disappeared After Hepatitis C Virus Eradication With Direct-Acting Antiviral Treatment. Reviewed International journal

    Norihiro Sakai, Kenya Kamimura, Shuji Terai

    The American journal of gastroenterology   116 ( 2 )   237 - 237   2021.2

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    DOI: 10.14309/ajg.0000000000000703

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  • Changes in disease characteristics of primary biliary cholangitis: An observational retrospective study from 1982 to 2016. International journal

    Masaaki Takamura, Yasunobu Matsuda, Naruhiro Kimura, Masafumi Takatsuna, Toru Setsu, Atsunori Tsuchiya, Akihiko Osaki, Nobuo Waguri, Masahiko Yanagi, Toru Takahashi, Soichi Sugitani, Yuka Kobayashi, Akira Yoshikawa, Toru Ishikawa, Toshiaki Yoshida, Toshiaki Watanabe, Hitoshi Bannai, Tomoyuki Kubota, Kazuhiro Funakoshi, Hiroto Wakabayashi, So Kurita, Norio Ogata, Masashi Watanabe, Yuhsaku Mita, Shigeki Mori, Motoya Sugiyama, Toru Miyajima, Sumio Takahashi, Shuichi Sato, Kisei Ishizuka, Hironobu Ohta, Yutaka Aoyagi, Shuji Terai

    Hepatology research : the official journal of the Japan Society of Hepatology   51 ( 2 )   166 - 175   2021.2

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    AIM: Disease characteristics of primary biliary cholangitis have changed recently. However, detailed studies on the subject have been limited. Therefore, we aimed to clarify disease characteristics of patients with recent primary biliary cholangitis using the cohort from Niigata University and 21 affiliated hospitals. METHODS: Overall, 508 patients were enrolled in this study from 1982 to 2016, divided into three cohorts according to their year of diagnosis: ≤1999, 2000-2009 and ≥2010. We compared differences in clinical characteristics, response to ursodeoxycholic acid and prognosis. RESULTS: The male-to-female ratio increased incrementally from 1:16.4 (≤1999) to 1:3.8 (≥2010) (P < 0.001). In women, the median age at diagnosis increased incrementally from 54.0 years (≤1999) to 60.5 years (≥2010) (P < 0.001) and serum albumin decreased gradually (P = 0.001), which might have affected the increase in the Fibrosis-4 Index and albumin-bilirubin score. The ursodeoxycholic acid response rate according to the Barcelona criteria increased incrementally from 26.7% (≤1999) to 78.4% (≥2010) (P < 0.010), and those according to other criteria (Paris-I, Rotterdam and Toronto) were approximately ≥80% in all cohorts. Ten-year survival rate in the ≤1999 and 2000-2009 cohorts were 98.6% and 95.6%, respectively. These earlier cohorts were also characterized by a higher rate of asymptomatic state and mild histology (83.5% [≤1999] and 84.7% [2000-2009], and 93.6% [≤1999] and 91.1% [2000-2009]). CONCLUSIONS: Patients with primary biliary cholangitis were characterized by older age at diagnosis and an increase in male to female ratio as well as higher response rates of ursodeoxycholic acid and longer survival, resulting from the early recognition of primary biliary cholangitis.

    DOI: 10.1111/hepr.13586

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  • 【肝硬変診療ガイドラインの改正をめぐって】肝腎症候群

    坂牧 僚, 薛 徹, 阿部 寛幸, 上村 顕也, 高村 昌昭, 寺井 崇二

    消化器・肝臓内科   9 ( 2 )   155 - 159   2021.2

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  • Acute on chronicの新展開 当科における我が国の新診断基準でのAcute On Chronic Liver Failure症例の検討

    野尻 俊介, 土屋 淳紀, 阿部 聡司, 坂牧 僚, 上村 博輝, 上村 顕也, 高村 昌昭, 寺井 崇二

    肝臓   62 ( 2 )   107 - 107   2021.2

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  • Molecular Mechanisms and Treatment of Sarcopenia in Liver Disease: A Review of Current Knowledge. International journal

    Hiroteru Kamimura, Takeki Sato, Kazuki Natsui, Takamasa Kobayashi, Tomoaki Yoshida, Kenya Kamimura, Atsunori Tsuchiya, Toshiko Murayama, Junji Yokoyama, Hirokazu Kawai, Masaaki Takamura, Shuji Terai

    International journal of molecular sciences   22 ( 3 )   2021.1

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    Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength that occurs with aging or in association with various diseases. The condition is prevalent worldwide and occurs more frequently in patients with chronic diseases owing to the intrinsic relationship of muscles with glucose, lipid, and protein metabolism. Liver cirrhosis is characterized by the progression of necro-inflammatory liver diseases, which leads to fibrosis, portal hypertension, and a catabolic state, which causes loss of muscle tissue. Sarcopenia is of significant concern in the state of liver cirrhosis because sarcopenia has been associated with higher mortality, increased hospital admissions, worse post-liver transplant outcomes, decreased quality of life, and increased risk for other complications associated with cirrhosis. Therefore, sarcopenia is also an important feature of liver cirrhosis, representing a negative prognostic factor and influencing mortality. An increased understanding of sarcopenia could lead to the development of novel therapeutic approaches that could help improve the cognitive impairment of cirrhotic patients; therefore, we present a review of the mechanisms and diagnosis of sarcopenia in liver disease and existing therapeutic approaches.

    DOI: 10.3390/ijms22031425

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  • Usefulness of an artificial intelligence system for the detection of esophageal squamous cell carcinoma evaluated with videos simulating overlooking situation. International journal

    Kotaro Waki, Ryu Ishihara, Yusuke Kato, Ayaka Shoji, Takahiro Inoue, Katsunori Matsueda, Muneaki Miyake, Yusaku Shimamoto, Hiromu Fukuda, Noriko Matsuura, Yoichiro Ono, Kenshi Yao, Satoru Hashimoto, Shuji Terai, Masayasu Ohmori, Kyosuke Tanaka, Motohiko Kato, Takashi Shono, Hideaki Miyamoto, Yasuhito Tanaka, Tomohiro Tada

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   33 ( 7 )   1101 - 1109   2021.1

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    OBJECTIVES: Artificial intelligence (AI) systems have shown favorable performance in the detection of esophageal squamous cell carcinoma (ESCC). However, previous studies were limited by the quality of their validation methods. In this study, we evaluated the performance of an AI system with videos simulating situations in which ESCC has been overlooked. METHODS: We used 17,336 images from 1376 superficial ESCCs and 1461 images from 196 noncancerous and normal esophagi to construct the AI system. To record validation videos, the endoscope was passed through the esophagus at a constant speed without focusing on the lesion to simulate situations in which ESCC has been missed. Validation videos were evaluated by the AI system and 21 endoscopists. RESULTS: We prepared 100 video datasets, including 50 superficial ESCCs, 22 noncancerous lesions, and 28 normal esophagi. The AI system had sensitivity of 85.7% (54 of 63 ESCCs) and specificity of 40%. Initial evaluation by endoscopists conducted with plain video (without AI support) had average sensitivity of 75.0% (47.3 of 63 ESCC) and specificity of 91.4%. Subsequent evaluation by endoscopists was conducted with AI assistance, which improved their sensitivity to 77.7% (P = 0.00696) without changing their specificity (91.6%, P = 0.756). CONCLUSIONS: Our AI system had high sensitivity for the detection of ESCC. As a support tool, the system has the potential to enhance detection of ESCC without reducing specificity. (UMIN000039645).

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  • Transcatheter Arterial Embolization Using Microspheres for Palliating Pain from Bone Metastasis in a Patient with Cholangiocellular Carcinoma.

    Shinichi Morita, Shunsuke Sugawara, Takeshi Suda, Didik Prasetyo, Takahiro Hoshi, Satoshi Abe, Kazuyoshi Yagi, Shuji Terai

    Internal medicine (Tokyo, Japan)   60 ( 2 )   241 - 246   2021.1

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    A 72-year-old man with intractable left shoulder pain due to bone metastasis from cholangiocellular carcinoma was admitted to our hospital. Computed tomography showed an osteoblastic metastatic lesion of the left scapula. Since the pain persisted even after the administration of opioids and external irradiation, microspheres were injected through a catheter; the catheter tip was placed at the arteries feeding the metastatic lesion. After the intervention, the shoulder pain was alleviated without any procedure-related complications, leading to a reduction in the opioid dose. This case suggests the efficacy of transcatheter arterial embolization using microspheres for palliating pain from bone metastasis.

    DOI: 10.2169/internalmedicine.5351-20

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  • Comparison of Oral and Esophageal Microbiota in Patients with Achalasia Before and After Peroral Endoscopic Myotomy. International journal

    Kazuya Takahashi, Hiroki Sato, Takeshi Mizusawa, Kentaro Tominaga, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology   32 ( 1 )   42 - 52   2021.1

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    BACKGROUND/AIMS: Patients with achalasia have a high incidence of esophageal squamous cell carcinoma (ESCC), which may be associated with alterations in oral and esophageal microbiota caused by food stasis. This study compared the oral and esophageal microbiota of patients with achalasia before and after peroral endoscopic myotomy (POEM). It also compared patients with achalasia to those with ESCC. MATERIALS AND METHODS: The study prospectively examined 6 patients with achalasia and 14 with superficial ESCC. Oral samples obtained from the buccal mucosa using a swab and esophageal samples obtained from the mid-esophagus using a brush via endoscopy were analyzed by 16S rRNA metagenome sequencing. Additionally, endoscopic and histological findings of patients with achalasia before and after POEM were prospectively compared. RESULTS: In patients with achalasia, Streptococcus was most abundant in both the oral and the esophageal microbiota, and these microbiota were significantly different. Although the overall structure of the oral and esophageal microbiota did not change after POEM, the relative abundance rate of Haemophilus and Neisseria increased in the esophagus, and endoscopic findings of inflammation improved after POEM (P = .04). The relative abundance of microbiota was not different among patients with achalasia from those with ESCC. CONCLUSIONS: The oral and esophageal microbiota were significantly different in patients with achalasia, and some of the composition of the esophageal microbiota changed after POEM. However, these findings and disease-specific microbiota should be further evaluated in large-scale studies.

    DOI: 10.5152/tjg.2020.19995

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  • The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future. International journal

    Yusuke Watanabe, Atsunori Tsuchiya, Shuji Terai

    Clinical and molecular hepatology   27 ( 1 )   70 - 80   2021.1

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    Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for decreasing mortality is liver transplantation. However, transplant surgery is highly invasive. Therefore, cell-based therapy has been developed as an alternative. Based on promising findings from preclinical research, some new trials have been registered. One of them was autologous bone marrow cell infusion therapy and found that ameliorating liver fibrosis activated liver regeneration. Now, majority of trials focus on low-immunogenicity mesenchymal stem cells (MSCs) appropriate for allogeneic administration. However, despite about 20 years of research, only a limited number of cell-based therapies have entered routine practice. Furthermore, potential shortcomings of cell-based therapy include a limit on the number of cells, which may be administered, as well as their failure to infiltrate target organs. On the other hand, these research show that MSCs act as "conducting cells" and regulate host cells including macrophages via extracellular vesicles (EVs) or exosome signals, leading to ameliorate liver fibrosis and promote regeneration. Therefore, the concept of cell-free therapy, which makes use of cell-derived EVs or exosomes, is attracting attention. Cell-free therapies may be safely administered in large doses and are able to infiltrate target organs. However, development of cell-free therapy exhibits its own set of challenges and such therapy may not be completely curative in the context of liver disease. This review describes the history of cell-based therapy research and recent advances in cell-free therapy, as well as discussing the need for more effective therapies.

    DOI: 10.3350/cmh.2020.0194

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  • Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study.

    Yuki Tahata, Hayato Hikita, Satoshi Mochida, Norifumi Kawada, Nobuyuki Enomoto, Akio Ido, Hitoshi Yoshiji, Daiki Miki, Yoichi Hiasa, Yasuhiro Takikawa, Ryotaro Sakamori, Masayuki Kurosaki, Hiroshi Yatsuhashi, Ryosuke Tateishi, Yoshiyuki Ueno, Yoshito Itoh, Taro Yamashita, Tatsuya Kanto, Goki Suda, Yasunari Nakamoto, Naoya Kato, Yasuhiro Asahina, Kentaro Matsuura, Shuji Terai, Kazuhiko Nakao, Masahito Shimizu, Taro Takami, Norio Akuta, Ryoko Yamada, Takahiro Kodama, Tomohide Tatsumi, Tomomi Yamada, Tetsuo Takehara

    Journal of gastroenterology   56 ( 1 )   67 - 77   2021.1

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    BACKGROUND: Real-world data on the efficacy and safety of sofosbuvir plus velpatasvir (SOF/VEL) treatment for patients with hepatitis C virus (HCV)-related decompensated cirrhosis are limited in Japan. METHODS: A total of 190 patients with compensated (108) or decompensated (82) cirrhosis who initiated direct-acting antiviral (DAA) treatment between February 2019 and August 2019 were enrolled. Sustained virologic response (SVR) was defined as undetectable serum HCV-RNA at 12 weeks after the end of treatment (EOT). RESULTS: The SVR12 rates were 92.6% in patients with compensated cirrhosis and 90.2% in patients with decompensated cirrhosis (p = 0.564), and the treatment completion rates were 98.1% and 96.3%, respectively (p = 0.372). In patients with decompensated cirrhosis, 3 patients discontinued treatment and 2 patients died because of liver-related events. In patients with decompensated cirrhosis with SVR12, 50% of patients with Child-Pugh class B at baseline showed improvement to class A at SVR12, and 27% and 9% of patients with Child-Pugh class C at baseline showed improvement to class B and class A at SVR12, respectively. Patients who achieved SVR12 showed elevated serum albumin levels at the EOT, which were further elevated at SVR12, but no elevated serum albumin levels after the EOT were observed in patients with baseline serum albumin levels less than 2.8 g/dl. CONCLUSIONS: Real-world efficacy of SOF/VEL treatment for patients with decompensated cirrhosis was similar to Japanese phase 3 study, although treatment discontinuation and death related to liver disease occurred. In patients with poor hepatic reserve, whether it improves continuously after viral clearance requires further evaluation.

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  • 【新しい肝硬変診療〜ガイドライン2020を紐解く〜】肝硬変診療の課題と今後の展望

    寺井 崇二, 坂牧 僚

    日本消化器病学会雑誌   118 ( 1 )   41 - 45   2021.1

  • Visceral Adipose Tissue Index and Hepatocellular Carcinoma Are Independent Predictors of Outcome in Patients with Cirrhosis Having Endoscopic Treatment for Esophageal Varices. Reviewed International journal

    Naruhiro Kimura, Atsunori Tsuchiya, Chiyumi Oda, Atsushi Kimura, Kazunori Hosaka, Kentaro Tominaga, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    Digestive diseases (Basel, Switzerland)   39 ( 1 )   58 - 65   2021

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    BACKGROUND: The relationship between the amount of adipose tissue and advanced-stage liver cirrhosis with esophageal varices (EV) is unknown. We aimed to reveal the prognostic significance of adipose tissues in patients with liver cirrhosis. METHODS: We enrolled 87 patients with EV who received initial endoscopic treatment and underwent scheduled treatments in our hospital. Computed tomography (CT) images were obtained of a 5-mm slice at the umbilical level. We evaluated the effect of mortality based on the visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and visceral to subcutaneous adipose tissue ratio (VSR). RESULTS: Cox hazard multivariate analysis showed that the presence of hepatocellular carcinoma (HCC; hazard ratio [HR]: 4.650, 95% confidence interval [CI]: 1.750-12.353, p = 0.002), γ-GTP (HR: 1.003, 95% CI: 1.001-1.006, p = 0.026), and VATI (HR: 1.057, 95% CI: 1.030-1.085, p < 0.001) significantly affected mortality. Cox hazard multivariate analysis for liver-related death was also significantly affected by HCC (HR: 1.057, 95% CI: 1.030-1.085, p < 0.001) and VATI (HR: 1.052, 95% CI: 1.019-1.086, p = 0.002). The difference between the Child-Pugh scores 12 months after treatment and that during initial treatment were significantly positively correlated with VATI (r = 0.326, p = 0.027). Patients with high VATI had a significantly higher frequency of HCC after EV treatment by Kaplan-Meier analysis (p = 0.044). CONCLUSION: Our findings suggest that VATI measured by CT could significantly predict mortality in cirrhosis patients through decreasing liver function and increasing HCC frequency, and appropriately controlling VATI could improve their prognosis.

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  • [Problems and future questions in the clinical practice of liver cirrhosis].

    Shuji Terai, Akira Sakamaki

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   118 ( 1 )   41 - 45   2021

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    DOI: 10.11405/nisshoshi.118.41

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  • Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia.

    Kentaro Tominaga, Atsunori Tsuchiya, Oki Nakano, Yasutoshi Kuroki, Kentaro Oka, Ayaka Minemura, Asami Matsumoto, Motomichi Takahashi, Yoshihiro Kadota, Takumi Tochio, Yusuke Niwa, Tomoaki Yoshida, Masatoshi Sato, Takeshi Yokoo, Satoru Hashimoto, Junji Yokoyama, Jun Matsuzawa, Katsuya Fujimori, Shuji Terai

    Bioscience of microbiota, food and health   40 ( 3 )   150 - 155   2021

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    Sarcopenia causes functional disorders and decreases the quality of life. Thus, it has attracted substantial attention in the aging modern world. Dysbiosis of the intestinal microbiota is associated with sarcopenia; however, it remains unclear whether prebiotics change the microbiota composition and result in the subsequent recovery of muscle atrophy in elderly patients with sarcopenia. This study aimed to assess the effects of prebiotics in super-elderly patients with sarcopenia. We analyzed the effects of 1-kestose on the changes in the intestinal microbiota and body composition using a next-generation sequencer and a multi-frequency bioimpedance analysis device. The Bifidobacterium longum population was significantly increased in the intestine after 1-kestose administration. In addition, in all six patients after 12 weeks of 1-kestose administration, the skeletal muscle mass index was greater, and the body fat percentage was lower. This is the first study to show that administration of a prebiotic increased the population of B. longum in the intestinal microbiota and caused recovery of muscle atrophy in super-elderly patients with sarcopenia.

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  • Novel Strategy for Diagnosis of Focal Nodular Hyperplasia Using Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid: Enhanced Magnetic Resonance Imaging and Magnetic Resonance Elastography

    Nobutaka Takeda, Atsunori Tsuchiya, Kazuki Natsui, Yui Ishii, Yoshihisa Arao, Naruhiro Kimura, Kentaro Tominaga, Suguru Takeuchi, Kazunao Hayashi, Masaaki Takamura, Shuji Terai

    CASE REPORTS IN GASTROENTEROLOGY   15 ( 2 )   507 - 512   2021

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    DOI: 10.1159/000516552

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  • Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort

    Naitoh, I., Kamisawa, T., Tanaka, A., Nakazawa, T., Kubota, K., Takikawa, H., Unno, M., Masamune, A., Kawa, S., Nakamura, S., Okazaki, K., Furumatsu, K., Sawai, S., Goto, T., Okumura, T., Suzuki, D., Otsuka, M., Kobori, I., Tamano, M., Koizumi, M., Hiasa, Y., Kawabe, N., Hirooka, Y., Yamamoto, S., Asano, Y., Inui, K., Horiguchi, A., Watanabe, H., Toya, D., Hatayama, K., Ueki, T., Kinoshita, N., Sugimoto, M., Ohira, H., Mukai, T., Tomita, E., Iwata, K., Shimizu, S., Suetsugu, J., Shimizu, M., Tsuji, K., Ishida, R., Ito, M., Furukawa, R., Sakamoto, N., Araki, M., Tanno, S., Sakamoto, Y., Ito, T., Takai, S., Ikeya, S., Yamada, T., Kudara, N., Shimizu, A., Hanada, K., Ichiki, Y., Kitada, H., Hifumi, M., Kimura, H., Kurosaki, M., Izumi, N., Sumi, H., Haruta, J.-I., Hayashi, K., Harada, R., Inoue, M., Nakamura, S., Ito, T., Tomishima, K., Isayama, H., Oura, K., Masaki, T., Shimokawahara, N., Tanoue, S., Maemura, K., Ido, A., Mizushima, I., Kawano, M., Yoshida, K., Naganuma, M., Murata, M., Nishio, A., Fujita, Y., Teratani, T., Matsubara, S., Tamai, H., Yoshida, Y., Azemoto, R., Kamata, K., Watanabe, T., Kurosu, T., Koizumi, W., Fujita, J., Seki, H., Ueda, Y., Fukumoto, T., Kousaki, T., Uchida, K., Ochiai, T., Kawasaki, T., Tanaka, M., Ishida, E., Notohara, K., Mori, H., Mori, T., Kawabata, H., Miyata, M., Sakagami, J., Itoh, Y., Shiokawa, M., Seno, H., Watanabe, N., Kataoka, H., Aoki, T., Fujishiro, M., Niihara, T., Nishimata, H., Mitoro, A., Yoshiji, H., Yoshida, M., Ikeda, M., Tomita, K., Hokari, R., Hayasaka, K., Amano, Y., Shioji, K., Hayashi, K., Terai, S., Nakajima, M., Yamahana, J., Matsumoto, R., Kikuchi, H., Kanamori, A., Kiriyama, S., Iwatsu, S., Kato, Y., Horiguchi, S., Yagi, T., Okada, H., Ohkawa, K., Hirao, M., Hiramatsu, N., Oza, N., Imamura, H., Baba, T., Nakano, S., Shinobi, T., Ryozawa, S., Motoya, M., Nakase, H., Kinoshita, N., Ito, K., Miyake, T., Kohge, N., Tobita, H., Joshita, S., Umemura, T., Kawaguchi, S., Ohno, K., Sonobe, K., Satoh, A., Shimosegawa, T., Miura, F., Yagi, M., Sano, K., Kin, T., Katanuma, A., Koike, K., Miura, S., Kawashima, Y., Kagawa, T., Azuma, S., Watanabe, M., Honjyo, M., Itoi, T., Honda, A., Kobayashi, K., Asano, T., Mizuno, S., Nishino, T., Taniguchi, H., Tajiri, K., Yasuda, I., Tanaka, Y., Oe, S., Harada, M., Kurata, M., Fukasawa, M., Enomoto, N., Kawaji, Y., Kitano, M., Nishise, Y., Hirakawa, H., Ishizawa, T., Ueno, Y., Kaino, M., Fujimoto, Y., Sakaida, I.

    Digestive and Liver Disease   53 ( 10 )   2021

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  • Liver cirrhosis with ruptured splenic artery aneurysm leading to hepatitis c treatment: A case report

    Hojo, Y., Kamimura, H., Owaki, T., Kimura, R., Iwasawa, T., Watanabe, Y., Takatsuna, M., Ikarashi, S., Takamura, M., Setsu, T., Arao, Y., Horii, Y., Sato, T., Terai, S.

    Kanzo/Acta Hepatologica Japonica   62 ( 11 )   2021

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  • Predicting Cervical Lymph Node Metastasis Following Endoscopic Surgery in Superficial Head and Neck Carcinoma. International journal

    Ryuichi Okabe, Yushi Ueki, Riuko Ohashi, Manabu Takeuchi, Satoru Hashimoto, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Hiroshi Matsuyama, Hajime Umezu, Shuji Terai, Yoichi Ajioka, Arata Horii

    Frontiers in surgery   8   813260 - 813260   2021

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    BACKGROUND: Early detection of head and neck carcinoma (HNC) as superficial HNC (SHNC) identified using recently developed optical techniques, such as magnifying endoscopy and narrow-band imaging (NBI), in combination with endoscopic surgeries enables minimally invasive treatment with favorable outcomes for HNC. This study aimed to identify the predictive factors for the rare but important clinical issue of SHNC, namely cervical lymph node metastasis (CLNM), following endoscopic resection. METHODS: Sixty-nine patients with SHNC who underwent endoscopic resection were enrolled in the study. Clinical data, preoperative endoscopic findings, pathological findings, and treatment outcomes were retrospectively reviewed. Because the pharyngeal mucosa lacks the muscularis mucosa, we measured tumor thickness in permanent pathology as an alternative to the depth of invasion. Correlations with the occurrence of CLNM were statistically examined. RESULTS: The 5-year disease-specific survival rate was 100%. Of 69 patients, 3 (4.3%) developed CLNM. All had subepithelial but not epithelial tumors. The 0-IIa type in the macroscopic findings, type B2/B3 vessels in narrow-band imaging, tumors ≥ pathological stage T2, lymphatic invasion, positive surgical margins, and tumor thickness >1,000 μm showed significant correlations with CLNM following endoscopic resection. Furthermore, the classification of type B vessels was significantly associated with tumor thickness. CONCLUSION: The treatment outcomes following endoscopic resection for SHNC were favorable. The risk of CLNM following endoscopic resection in SHNC can be predicted by several preoperative endoscopic and postoperative pathological findings. Among them, the classification of type B vessels, which correlated with both tumor thickness and CLNM, might be a useful predictive factor.

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  • Outcomes of endoscopic ultrasound-guided biliary drainage in a general hospital for patients with endoscopic retrograde cholangiopancreatography-difficult transpapillary biliary drainage

    Kuraoka, N., Hashimoto, S., Matsui, S., Terai, S.

    Journal of Clinical Medicine   10 ( 18 )   2021

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    DOI: 10.3390/jcm10184105

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  • Unresectable primary hepatic adenosquamous carcinoma successfully treated with systemic and transcatheter hepatic arterial injection chemotherapies followed by conversion surgery: a case report and literature review

    Watanabe, Y., Osaki, A., Kimura, K., Yakubo, S., Takaku, K., Sato, M., Hashidate, H., Waguri, N., Terai, S.

    BMC Gastroenterology   21 ( 1 )   2021

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    DOI: 10.1186/s12876-021-02070-3

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  • Choledochocele observed on direct peroral cholangioscopy using an ultra-slim endoscope.

    Satoshi Ikarashi, Kazunao Hayashi, Shuji Terai

    Journal of hepato-biliary-pancreatic sciences   2020.12

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    DOI: 10.1002/jhbp.884

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  • Monitoring chronological change by liver-to-spleen attenuation ratio for secondary hepatic steatosis for a short term. Reviewed

    Hiroteru Kamimura, Kunihiko Yokoyama, Shunsuke Nojiri, Yuko Komoro, Toshiko Murayama, Yu Koyama, Kenya Kamimura, Masaaki Takamura, Junji Yokoyama, Shuji Terai

    Clinical journal of gastroenterology   13 ( 6 )   1219 - 1224   2020.12

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    Parenteral nutrition-associated liver disease (PNALD) causes hepatic steatosis and moderate liver enzyme elevation due to lack of enteral nutrition and deficiency of some nutrients. However, the period for recovery from PNALD after a nutritional intervention is unknown with no report. Herein, we report a case of a 44-year-old Japanese woman with severe fatty infiltration of the liver due to malnutrition. Our nutritional support team administered appropriate total parenteral, especially fat and carnitine, nutrition to improve her malnutrition. Chronological changes in liver-to-spleen attenuation ratio were also considered because of her disease state. Computed tomography demonstrated improved attenuation of the liver, and the liver enzymes level normalized after 5 weeks from appropriate nutrition. Understanding the nutritional condition of a patient may help in elucidating an appropriate treatment strategy.

    DOI: 10.1007/s12328-020-01165-w

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  • Rare case of gastric perforation due to ischemic gastropathy. International journal

    Yui Ishii, Hiroki Sato, Shuji Terai

    Gastrointestinal endoscopy   92 ( 6 )   1266 - 1268   2020.12

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    DOI: 10.1016/j.gie.2020.06.061

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  • Daily Monitoring of Serum Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein Is Useful for Predicting Therapeutic Effect of Tolvaptan in Cirrhotic Ascites.

    Masaaki Takamura, Akira Sakamaki, Yoshihisa Arao, Toru Setsu, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    The Tohoku journal of experimental medicine   252 ( 4 )   287 - 296   2020.12

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    Wisteria floribunda agglutinin (WFA) is a lectin that binds to the sugar chain of Mac-2 binding protein (M2BP), and WFA-positive M2BP (WFA+-M2BP) has been reported as a useful marker for assessing liver fibrosis in chronic liver disease. Tolvaptan (TLV), a selective vasopressin V2 receptor antagonist, is used for cirrhotic ascites in Japan, but good predictors of treatment efficacy remain to be established. Our aim was to investigate whether WFA+-M2BP monitoring before and after TLV administration can predict treatment efficacy in patients with cirrhotic ascites. Twenty patients (10 men), with a median age of 72 years, were enrolled. Cirrhosis was caused by hepatitis B virus (n = 3), hepatitis C virus (n = 4), alcohol (n = 8), and others (n = 5). Responders were defined as having a body weight loss of ≥ 1.5 kg/week after TLV administration. Serum WFA+-M2BP levels were measured at baseline and days 1, 3, and 7 after TLV treatment. Twelve patients (60%) were responders. Baseline WFA+-M2BP levels were correlated with serum albumin levels (r = -0.544, P = 0.013). The baseline furosemide dose was lower and platelet count was higher in responders than in non-responders (P < 0.05). The ratio of WFA+-M2BP levels on day 1 after TLV administration to baseline was lower in responders than in non-responders (P < 0.05). The decrease in the ratio discriminated responders from non-responders (AUC = 0.844, P < 0.05). In conclusion, monitoring serum WFA+-M2BP is helpful for predicting the efficacy of TLV treatment in patients with cirrhotic ascites.

    DOI: 10.1620/tjem.252.287

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  • アルコール性肝硬変におけるALD/NAFLD Index低値例の臨床的特徴

    坂牧 僚, 横山 邦彦, 森田 真一, 上村 顕也, 高村 昌昭, 寺井 崇二

    アルコールと医学生物学   39   96 - 97   2020.12

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  • 急性肝炎後再生不良性貧血の1例

    阿部 聡司, 名古屋 拓郎, 土屋 淳紀, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   61 ( 12 )   753 - 753   2020.12

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  • キーワード(No.39) Leaky GUT

    夏井 一輝, 土屋 淳紀, 寺井 崇二

    消化器病学サイエンス   4 ( 4 )   227 - 227   2020.12

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  • Usefulness of ultrasonography to assess the response to steroidal therapy for the rare case of type 2b immunoglobulin G4-related sclerosing cholangitis without pancreatitis: A case report. International journal

    Yuto Tanaka, Kenya Kamimura, Ryota Nakamura, Marina Ohkoshi-Yamada, Yohei Koseki, Takeshi Mizusawa, Satoshi Ikarashi, Kazunao Hayashi, Hiroki Sato, Akira Sakamaki, Junji Yokoyama, Shuji Terai

    World journal of clinical cases   8 ( 22 )   5821 - 5830   2020.11

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    BACKGROUND: A type 2b immunoglobulin G4 (IgG4)-related sclerosing cholangitis (SC) without autoimmune pancreatitis is a rare condition with IgG4-SC. While the variety of the imaging modalities have tested its usefulness in diagnosing the IgG4-SC, however, the usage of ultrasonography for the assessment of the response to steroidal therapy on the changes of bile duct wall thickness have not been reported in the condition. Therefore, the information of our recent case and reported cases have been summarized. CASE SUMMARY: We report the case of an 82-year-old Japanese man diagnosed with isolated IgG4-related SC based on the increase of serum IgG4, narrowing of the bile duct, its wall thickness, no complication of autoimmune pancreatitis, and IgG4 positive inflammatory cell infiltration to the wall with the fibrotic changes. The cholangiogram revealed type 2b according to the classification. Corticosteroid treatment showed a favorable effect, with the smooth decrease in serum IgG4 and the improvement of the bile duct wall thickness. CONCLUSION: As isolated type 2b, IgG4-SC is rare, the images, histological findings, and clinical course of our case will be helpful for physicians to diagnose and treat the new cases appropriately.

    DOI: 10.12998/wjcc.v8.i22.5821

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  • Stent Placement for Malignant Inferior Vena Cava Syndrome in a Patient with Recurrent Colon Cancer.

    Shinichi Morita, Shunsuke Sugawara, Takeshi Suda, Didik Prasetyo, Yuka Kobayashi, Takahiro Hoshi, Satoshi Abe, Kazuyoshi Yagi, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 22 )   2885 - 2890   2020.11

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    A 70-year-old man was admitted to our hospital with gait disturbance due to marked edema of the lower limbs for more than 6 months. He had been receiving systemic chemotherapy over two years for multiple recurrence after sigmoid colon cancer resection. Contrast-enhanced computed tomography demonstrated severe inferior vena cava (IVC) stenosis due to compression by lymph node metastases, i.e. IVC syndrome. As increased doses of diuretic agents failed to improve the edema, IVC stent placement was performed. This led to significant improvement of the edema and complete gait normalization. This case demonstrates the efficacy of IVC stent placement for IVC syndrome.

    DOI: 10.2169/internalmedicine.5033-20

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  • Pancreas Gas Gangrene Caused by Klebsiella pneumoniae.

    Yui Ishii, Atsunori Tsuchiya, Kazunao Hayashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 22 )   2963 - 2964   2020.11

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    DOI: 10.2169/internalmedicine.5257-20

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  • Esophageal High-Resolution Manometry for Diagnosing the Severity of the Chronic Intestinal Pseudo-Obstruction: A Case Series. International journal

    Hiroki Sato, Kenya Kamimura, Hideaki Matsui, Takashi Owaki, Shinichi Morita, Yuto Tanaka, Natsuki Ishikawa, Yoshifumi Shimada, Junji Yokoyama, Toshifumi Wakai, Shuji Terai

    Digestive diseases and sciences   66 ( 11 )   3960 - 3967   2020.11

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    BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) is a severe and refractory intestinal motility disorder. However, due to its rarity and difficult histological investigation, its pathophysiology has not been characterized. AIM: Therefore, in this study, we aimed to determine the role of esophageal high-resolution manometry (HRM) in CIPO and the histological and clinical characteristics of the disease. METHODS: Patients with CIPO were analyzed for clinical characteristics; histological findings; and clinical courses after therapeutic intervention. In addition, HRM was performed to determine the esophageal involvement. RESULTS: Eleven patients were diagnosed with CIPO, and five required the long period of parenteral nutrition showing impaired esophageal motility including achalasia and absent contractility diagnosed with HRM. The four of these five cases showed acute onset of the CIPO following the triggering events of pregnancy, appendicitis, and surgery. In contrast, other six patients with normal or Jackhammer esophagus on HRM had moderate severity of CIPO with gradual onset. The histological analyses revealed that the loss of the intestinal neural ganglion cells and layers by inflammation, destruction, and atrophy are related to the severity of the clinical course of the disease and esophageal HRM findings of achalasia and absent contractility. CONCLUSIONS: HRM may be useful to diagnose the severity of the clinical course and to determine the therapeutic options for CIPO.

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  • 消化管疾患に対する低侵襲治療の現状と今後の展開-内科、外科の立場から- 当院における腹腔鏡・内視鏡合同手術(LECS)の現状と課題

    加納 陽介, 羽入 隆晃, 佐藤 裕樹, 水野 研一, 市川 寛, 石川 卓, 宗岡 悠介, 茂木 大輔, 須藤 翔, 小柳 英人, 三浦 宏平, 滝沢 一泰, 中野 雅人, 島田 能史, 永橋 昌幸, 坂田 純, 寺井 崇二, 若井 俊文

    日本消化器病学会甲信越支部例会抄録集   67回   69 - 69   2020.11

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  • Risk factors for walled-off necrosis associated with severe acute pancreatitis: A multicenter retrospective observational study.

    Satoshi Ikarashi, Hirokazu Kawai, Kazunao Hayashi, Junji Kohisa, Toshifumi Sato, Yujiro Nozawa, Shinichi Morita, Hiromitsu Oka, Munehiro Sato, Yukio Aruga, Seiichi Yoshikawa, Shuji Terai

    Journal of hepato-biliary-pancreatic sciences   27 ( 11 )   887 - 895   2020.11

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    BACKGROUND: This study aimed to identify the risk factors for walled-off necrosis (WON) associated with severe acute pancreatitis (SAP). METHODS: This retrospective study was conducted in eight institutions in Japan between 2014 and 2017. We analyzed WON incidence, patient characteristics, and risk factors for WON in patients with SAP who were observed for >28 days. RESULTS: Of 134 patients with SAP, WON occurred in 40 (29.9%). Male sex (P = .045), body mass index (BMI) ≥25 (P < .001), post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (P = .020), and disseminated intravascular coagulation (DIC) (P = .001) were more frequent in the WON group than in the non-WON group. On admission, the frequency of white blood cell counts ≥ 12 000/µL (P = .037) and hypoenhanced pancreatic lesion on computed tomography (P = .047) were significantly higher in the WON group. In multivariate analysis, BMI ≥ 25 (odds ratio [OR] 5.73, 95% confidence interval [CI] 1.95-16.8; P = .002), post-ERCP (OR 8.08, 95% CI 1.57-41.7; P = .013), and DIC (OR 3.52, 95% CI 1.20-10.4; P = .022) were independent risk factors for WON. CONCLUSIONS: High BMI, post-ERCP pancreatitis, and DIC are risk factors for the development of WON associated with SAP.

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  • ステロイド治療前後で肝硬度と病理像を評価し得た肝サルコイドーシスの一例

    水戸 將貴, 荒生 祥尚, 夏井 一輝, 前田 悠一郎, 小島 雄一, 林 和直, 土屋 敦紀, 梅津 哉, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   67回   95 - 95   2020.11

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  • 被包化膵壊死への真菌感染による敗血症性ショックをきたした一例

    山田 麻理奈[大越], 上村 顕也, 石川 夏生, 小関 洋平, 田中 裕登, 水澤 健, 佐藤 裕樹, 五十嵐 聡, 林 和直, 坂牧 僚, 横山 純二, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   67回   26 - 26   2020.11

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  • 良悪性鑑別困難な胆膵疾患の診断と治療の最前線-内科、外科の立場から- 自己免疫性膵炎と膵癌との鑑別の現状と課題

    小川 光平, 林 和直, 五十嵐 聡, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   67回   32 - 32   2020.11

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  • 急性腹症を契機にC型慢性肝炎が発見された1例

    北條 雄暉, 上村 博輝, 木村 莉菓, 大脇 崇史, 岩澤 貴宏, 渡邉 雄介, 高綱 将史, 荒生 祥尚, 薛 徹, 五十嵐 聡, 高村 昌昭, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   67回   96 - 96   2020.11

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  • 肝疾患に対するPrecision Medicineの実現可能性を探る:新規バイオマーカーを含めて 肝障害の程度、機能回復の指標としての血中セロトニンの検証

    薛 徹, 上村 顕也, 寺井 崇二

    肝臓   61 ( Suppl.3 )   A832 - A832   2020.11

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  • よりよい肝移植医療のあり方を探る 当県での移植へのゲートウェイとしてのネットワークシステムの取り組み

    薛 徹, 高村 昌昭, 寺井 崇二

    肝臓   61 ( Suppl.3 )   A800 - A800   2020.11

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  • ウイルス肝炎診療:新旧の課題と解決への戦略 当院・関連施設におけるソホスブビル/ベルパタスビル11症例での治療効果と安全性の検討

    荒生 祥尚, 薛 徹, 寺井 崇二

    肝臓   61 ( Suppl.3 )   A775 - A775   2020.11

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  • 短期間に急速な肝脂肪沈着と栄養・運動介入による肝機能の改善を確認できたアスリートの一例

    上村 博輝, 木村 莉菓, 北條 雄暉, 渡邊 雄介, 高綱 将史, 五十嵐 聡, 佐野 正和, 真田 奈緒, 武田 安永, 小師 優子, 高村 昌昭, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   67回   97 - 97   2020.11

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  • 令和の時代に求められる肝硬変の多角的治療戦略 十全大補湯と間葉系幹細胞の併用療法はCC14投与肝硬変モデルマウスにおいて効果的な抗炎症・抗線維化効果を及ぼす

    野尻 俊介, 土屋 淳紀, 寺井 崇二

    肝臓   61 ( Suppl.3 )   A853 - A853   2020.11

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  • 臨床応用を見据えた肝の臓器再生研究の展望 肝硬変に対する間葉系細胞治療とそのエクソソーム治療の可能性

    土屋 淳紀, 竹内 卓, 寺井 崇二

    肝臓   61 ( Suppl.3 )   A827 - A827   2020.11

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  • 【肝硬変診療の新時代】肝再生治療開発の現況

    竹内 卓, 渡邉 雄介, 土屋 淳紀, 寺井 崇二

    臨床消化器内科   35 ( 13 )   1601 - 1605   2020.11

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  • Shear wave elastographyを用いたNAFLDにおける肝線維化の左右差の検討

    横尾 健, 杉田 萌乃, 荒生 祥尚, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    超音波医学   47 ( Suppl. )   S349 - S349   2020.11

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  • 脂肪性肝疾患:治療のターゲットとゴール 脂肪性疾患の病態進行と自律神経ネットワークを介する臓器連関の関与

    上村 顕也, 大脇 崇史, 寺井 崇二

    肝臓   61 ( Suppl.3 )   A758 - A758   2020.11

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  • 進行肝細胞癌に対する集学的治療:エビデンスとコンセンサス 肝癌に対する放射線治療の安全性と有用性の検討

    上村 顕也, 大越 麻理奈, 寺井 崇二

    肝臓   61 ( Suppl.3 )   A811 - A811   2020.11

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  • MC4R遺伝子及びMaid遺伝子両欠損マウスを用いた新規脂肪肝モデルマウスの検討

    森田 真一, 坂牧 僚, 永山 逸夫, 大越 麻理奈, 小山 究太郎, 田中 裕登, 大脇 崇史, 小田 知友美, 柴田 理, 木村 淳史, 阿部 寛幸, 上村 顕也, 寺井 崇二

    肝臓   61 ( Suppl.3 )   A876 - A876   2020.11

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  • Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and its Role in Multidisciplinary Therapy. International journal

    Marina Ohkoshi-Yamada, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Motoki Kaidu, Toshimichi Nakano, Katsuya Maruyama, Atsushi Ota, Hirotake Saito, Nobuko Yamana, Tomoya Oshikane, Yukiyo Goto, Natsumi Yoshimura, Satoshi Tanabe, Hisashi Nakano, Madoka Sakai, Yuto Tanaka, Yohei Koseki, Yoshihisa Arao, Hiroyuki Abe, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Hidefumi Aoyama, Shuji Terai

    Cancers   12 ( 10 )   2020.10

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    This study investigated the efficacy and safety of radiotherapy as part of multidisciplinary therapy for advanced hepatocellular carcinoma (HCC). Clinical data of 49 HCC patients treated with radiotherapy were assessed retrospectively. The efficacy of radiotherapy was assessed by progression-free survival, disease control rate, and overall survival. Safety was assessed by symptoms and hematological assay, and changes in hepatic reserve function were determined by Child-Pugh score and albumin-bilirubin (ALBI) score. Forty patients underwent curative radiotherapy, and nine patients with portal vein tumor thrombus (PVTT) underwent palliative radiotherapy as part of multidisciplinary therapy. Local disease control for curative therapy was 80.0% and stereotactic body radiotherapy was 86.7% which was greater than that of conventional radiotherapy (60.0%). Patients with PVTT had a median observation period of 651 days and 75% three-year survival when treated with multitherapy, including radiotherapy for palliative intent, transcatheter arterial chemoembolization, and administration of molecular targeted agents. No adverse events higher than grade 3 and no changes in the Child-Pugh score and ALBI score were seen. Radiotherapy is safe and effective for HCC treatment and can be a part of multidisciplinary therapy.

    DOI: 10.3390/cancers12102955

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  • Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH. Reviewed International journal

    Tomoaki Yoshida, Atsunori Tsuchiya, Masaru Kumagai, Suguru Takeuchi, Shunsuke Nojiri, Takayuki Watanabe, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai

    Biochemical and biophysical research communications   530 ( 4 )   665 - 672   2020.10

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    The role of sphingosine 1-phosphate (S1P) and its sphingosine-1-phosphate receptors (S1PRs) in non-alcoholic steatohepatitis (NASH) is unclear. We aimed to analyze the role of S1P/S1PRs in a Melanocortin-4 receptor (Mc4r)-deficient NASH murine model using FTY720, the functional antagonist of S1PR1, S1PR3, S1PR4, and S1PR5, and JTE-013, the antagonist of S1PR2. We observed that, compared to that in the control, the mRNA of S1pr1 tended to decrease, whereas those of S1pr2 and S1pr3 significantly increased in Mc4r-knockout (KO) mice subjected to a Western diet (WD). While the fat area did not differ, fibrosis progression differed significantly between control mice and mice in which liver S1PRs were blocked. Lipidomic and metabolomic analysis of liver tissues showed that JTE-013-administered mice showed elevation of S-adenosyl-l-methionine level, which can induce aberrant methylation due to reduction in glycine N-methyltransferase (GNMT) and elevation in diacylglycerol (DG) and triacylglycerol (TG) levels, leading to increased susceptibility to hepatocellular carcinoma (HCC). These phenotypes are similar to those of Gnmt-KO mice, suggesting that blocking the S1P/S1PR2 axis triggers aberrant methylation, which may increase DG and TG, and hepatocarcinogenesis. Our observations that the S1P/S1PR2 axis averts HCC occurrence may assist in HCC prevention in NASH.

    DOI: 10.1016/j.bbrc.2020.07.099

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  • Screening and follow-up of chronic liver diseases with understanding their etiology in clinics and hospitals. International journal

    Masahiro Ogawa, Atsunori Tsuchiya, Takayuki Watanabe, Toru Setsu, Naruhiro Kimura, Masato Matsuda, Yoshiki Hoshiyama, Hiroaki Saito, Tsutomu Kanazawa, Motoi Shiotani, Tatsuhiko Sato, Takuya Yagi, Koji Igarashi, Norihiko Yoshimura, Masaaki Takamura, Hidefumi Aoyama, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   4 ( 5 )   827 - 837   2020.10

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    Background and Aim: Considering the increasing prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH), the development of an effective screening and follow-up system that enables the recognition of etiological changes by primary physicians in clinics and specialists in hospitals is required. Methods: Chronic hepatitis B (HBV) and C (HCV), NASH, and alcoholic steatohepatitis (ASH) patients who were assayed for Mac-2-binding protein glycosylation isomer (M2BPGi) (n = 272) and underwent magnetic resonance elastography (MRE) (n = 119) were enrolled. Patients who underwent MRE were also tested by ultrasound elastography (USE) (n = 80) and for M2BPGi (n = 97), autotaxin (ATX) (n = 62), and platelet count (n = 119), and their fibrosis-4 (FIB-4) index was calculated (n = 119). Results: FIB-4 index >2, excluding HBV-infected patients, M2BPGi >0.5, ATX >0.5, and platelet count <20 × 104/μL were the benchmark indices, and we took into consideration other risk factors, such as diabetes mellitus and age, to recommend further examinations, such as USE, based on the local situation to avoid overlooking hepatocellular carcinoma (HCC) in the clinic. During specialty care in the hospital, MRE exhibited high diagnostic ability for fibrosis stages >F3 or F4; it could efficiently predict collateral circulation with high sensitivity, which can replace USE. We also identified etiological features and found that collateral circulation in NASH/ASH patients tended to exceed high-risk levels; moreover, these patients exhibited more variation in HCC-associated liver stiffness than the HBV and HCV patients. Conclusions: Using appropriate markers and tools, we can establish a stepwise, practical, noninvasive, and etiology-based screening and follow-up system in primary and specialty care.

    DOI: 10.1002/jgh3.12406

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  • Refractory hemorrhagic esophageal ulcers by Candida esophagitis with advanced systemic sclerosis. International journal

    Kazuki Natsui, Atsunori Tsuchiya, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   4 ( 5 )   1007 - 1008   2020.10

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    A 64-year-old woman diagnosed with rheumatoid arthritis (RA) and systemic sclerosis (SSc) was admitted to our hospital with chief complaints of uncontrolled bleeding from esophageal ulcers and an inability to consume meals. For RA and SSc, she was treated with prednisolone and abatacept and was taking vonoprazan as prophylaxis for steroid-induced gastric ulcers. She was diagnosed with severe Candida esophagitis, with multiple large and small ulcers with bleeding, based on esophagogastroduodenoscopy and pathological findings. We performed comprehensive treatment; abatacept was discontinued, and total parenteral nutrition was initiated along with antifungal therapy. Improvement in the esophageal ulcers was observed. Although severe Candida esophagitis is a rare condition, we should keep in mind that severe Candida esophagitis can occur in patients with an immunosuppressive compromised host and esophageal movement disorders such as SSc. Regular follow up by endoscopy and prophylactic treatment to prevent severe esophagitis may be necessary.

    DOI: 10.1002/jgh3.12353

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  • 重症急性膵炎後Walled-off necrosisの内視鏡治療におけるLumen apposing metal stentの有効性

    五十嵐 聡, 林 和直, 寺井 崇二

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2162 - 2162   2020.10

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  • 急性膵炎およびその合併症治療の最前線 新潟県における重症急性膵炎の予後改善を目指して Niigata SAP network

    林 和直, 五十嵐 聡, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増大会 )   A624 - A624   2020.10

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  • 食道・胃静脈瘤治療の現状と今後の展望 門亢症の病態から考えたEIS/EVLの長期予後

    薛 徹, 横山 純二, 寺井 崇二

    日本門脈圧亢進症学会雑誌   26 ( 3 )   68 - 68   2020.10

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  • 【肝硬変のトータルマネジメント】肝腎症候群に対する治療 海外での動向

    坂牧 僚, 薛 徹, 阿部 寛幸, 上村 顕也, 高村 昌昭, 寺井 崇二

    肝臓クリニカルアップデート   6 ( 2 )   205 - 211   2020.10

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  • 再生医療はどこまで進んだか(vol.17) 間葉系幹細胞投与による肝線維化改善、再生誘導効果 基礎研究成果の臨床応用

    寺井 崇二, 土屋 淳紀

    医学のあゆみ   275 ( 4 )   367 - 370   2020.10

  • Translational researchを目指した下部消化管研究 炎症性腸疾患に対する間葉系幹細胞(MSC)、エクソソーム療法の可能性の検討

    川田 雄三, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増大会 )   A602 - A602   2020.10

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  • 肝性脳症〜わが国における現状と課題〜 潜在性肝性脳症患者における呼気中水素・メタン分析の有用性の検討

    坂牧 僚, 横山 邦彦, 小山 究太郎, 森田 真一, 阿部 寛幸, 上村 顕也, 高村 昌昭, 横山 純二, 寺井 崇二

    日本門脈圧亢進症学会雑誌   26 ( 3 )   76 - 76   2020.10

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  • 急性膵炎およびその合併症治療の最前線 新潟県における重症急性膵炎の予後改善を目指して Niigata SAP network

    林 和直, 五十嵐 聡, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増大会 )   A624 - A624   2020.10

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  • Synchronous Double Bile Duct Cancers with Distinct Genetic Features.

    Shinichi Morita, Takeshi Suda, Yoji Kishi, Toshimitsu Iwasaki, Nobuyoshi Hiraoka, Itsuo Nagayama, Takahiro Hoshi, Satoshi Abe, Kazuyoshi Yagi, Go Hasegawa, Toshihiko Ikarashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 17 )   2129 - 2134   2020.9

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    A 69-year-old man was referred to our hospital because of appetite loss. Imaging showed a nodular tumor in the perihilar bile duct and a second flat lesion in the distal bile duct. Right hepatopancreaticoduodenectomy was performed, and the histopathological findings demonstrated that the perihilar and distal lesions were moderately and poorly differentiated adenocarcinoma, respectively, and anatomically separated. Furthermore, the resected specimens showed no pancreaticobiliary maljunction. Histological and TP53 gene analyses in a rare case of synchronous double bile duct cancers suggest that there are various genetic pathways through which bile duct cancer develops, highlighting the complexity of its pathogenesis.

    DOI: 10.2169/internalmedicine.4613-20

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  • Transcriptomic Dissection of Hepatocyte Heterogeneity: Linking Ploidy, Zonation, and Stem/Progenitor Cell Characteristics Reviewed

    Takeshi Katsuda, Kazunori Hosaka, Juntaro Matsuzaki, Wataru Usuba, Marta Prieto-Vila, Tomoko Yamaguchi, Atsunori Tsuchiya, Shuji Terai, Takahiro Ochiya

    Cellular and Molecular Gastroenterology and Hepatology   9 ( 1 )   161 - 183   2020.9

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    DOI: 10.1016/j.jcmgh.2019.08.011

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  • 2D-Shear Wave ElastographyとTransient Elastographyの乖離症例の特徴

    杉田 萌乃, 横尾 健, 荒生 祥尚, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A695 - A695   2020.9

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  • 健診受検者における年齢層別NAFLDの解析と高齢者の意識変化

    横尾 健, 佐藤 公俊, 丹羽 佑輔, 荒生 祥尚, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A671 - A671   2020.9

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  • mALBI score/gradeからみたNASH薬物治療に対する肝予備能への影響

    高村 昌昭, 横尾 健, 荒生 祥尚, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A691 - A691   2020.9

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  • 2D-Shear Wave ElastographyとTransient Elastographyの乖離症例の特徴

    杉田 萌乃, 横尾 健, 荒生 祥尚, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A695 - A695   2020.9

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  • mALBI score/gradeからみたNASH薬物治療に対する肝予備能への影響

    高村 昌昭, 横尾 健, 荒生 祥尚, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A691 - A691   2020.9

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  • 健診受検者における年齢層別NAFLDの解析と高齢者の意識変化

    横尾 健, 佐藤 公俊, 丹羽 佑輔, 荒生 祥尚, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A671 - A671   2020.9

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  • 消化器疾患に対する再生医療の応用 間葉系幹細胞の治療効果メカニズム検証に基づく肝硬変に対するより効果的な治療法開発

    土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A583 - A583   2020.9

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  • Effectiveness of Endoscopic Pancreatic Stenting for Pancreatic Pseudocyst-Portal Vein Fistula

    Atsushi Kimura, Kazunao Hayashi, Chiyumi Oda, Kazunori Hosaka, Naruhiro Kimura, Kentaro Tominaga, Satoshi Ikarashi, Atsunori Tsuchiya, Shuji Terai

    CASE REPORTS IN GASTROENTEROLOGY   14 ( 3 )   570 - 576   2020.9

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    DOI: 10.1159/000510331

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  • 脂肪性肝疾患における自律神経系ネットワークを介したセロトニンの関与

    大脇 崇史, 上村 顕也, 高 昌良, 名古屋 拓郎, 永山 逸夫, 大越 麻理奈, 薛 徹, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A670 - A670   2020.9

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  • 肝臓を基軸とした臓器連関 肝臓を基軸とし自律神経系経路を介する多臓器連関の肝病態への関与の解明

    上村 顕也, 大脇 崇史, 寺井 崇二

    肝臓   61 ( Suppl.2 )   A613 - A613   2020.9

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  • Portal Vein Thrombosis Associated with Trousseau Syndrome due to Urinary Bladder Squamous Cell Carcinoma in a Liver Cirrhosis Patient. Reviewed

    Naruhiro Kimura, Atsunori Tsuchiya, Chiyumi Oda, Atsushi Kimura, Kazunori Hosaka, Kentaro Tominaga, Kazunao Hayashi, Tatsuya Abé, Hajime Umezu, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 16 )   1971 - 1975   2020.8

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    A 75-year-old woman with liver cirrhosis was admitted for treatment of portal vein thrombosis (PVT). Computed tomography (CT) showed PVT, massive ascites, and multiple abdominal organ embolism. Blood tests revealed a decreased liver function (Child-Pugh grade C). Language impairment followed by progressive left hemi-paralysis was subsequently detected. Magnetic resonance imaging revealed multiple small acute cerebral infarctions and, on CT, a 30-mm bladder tumour; a biopsy specimen examination showed squamous cell carcinoma. Her general condition worsened rapidly, and the best supportive care was chosen. Our findings suggest that, in patients with PVT, Trousseau syndrome should be considered, even in cases of liver cirrhosis.

    DOI: 10.2169/internalmedicine.4112-19

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  • Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review. Reviewed

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Takeshi Mizusawa, Shinichi Morita, Yui Ishii, Nobutaka Takeda, Kazuki Natsui, Yuzo Kawata, Naruhiro Kimura, Yoshihisa Arao, Kazuya Takahashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 16 )   1983 - 1989   2020.8

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    Ulcerative colitis, a chronic and recurrent inflammatory disease, is localized to the colonic mucosa but can affect other organs and lead to various complications. Gastroduodenitis associated with ulcerative colitis has been reported. However, little is known about esophageal ulcers. We herein report two rare cases of esophageal ulcers associated with ulcerative colitis. Furthermore, the clinical and histological characteristics of 18 previously reported cases are summarized. This case series and literature review will encourage the accurate diagnosis and treatment of esophageal ulcers associated with ulcerative colitis.

    DOI: 10.2169/internalmedicine.4437-20

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  • Advanced squamous cell carcinoma in an asymptomatic, large, epiphrenic esophageal diverticulum.

    Tomoaki Yoshida, Satoru Hashimoto, Ken-Ichi Mizuno, Hiroshi Ichikawa, Junji Yokoyama, Hajime Umezu, Shuji Terai

    Clinical journal of gastroenterology   13 ( 4 )   477 - 482   2020.8

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    An asymptomatic epiphrenic diverticulum (ED) was diagnosed in a man undergoing annual esophagogastroduodenoscopy (EGD) at another hospital 40 years before he presented to our hospital at age 63 years for his annual EGD. However, because substantial food retention was found in the ED, we could not confirm a lesion. After the retained food was removed endoscopically, a second EGD showed a reddish, flat lesion with an elevated mass within the ED. Endoscopic ultrasonography indicated that the elevated mass was deep in the submucosal layer. An esophagram showed that the ED was approximately 80 mm in diameter, which is considered large. An endoscopic biopsy of the lesion confirmed squamous cell carcinoma. Total esophagectomy was performed. Microscopic examination revealed well-differentiated to moderately differentiated squamous cell carcinoma invading the adventitia at the elevated lesion. The final pathological stage was pT3N0M0. There was no evidence of recurrence for 3 years during the quarterly follow-up examinations. To our knowledge, this case involved the longest asymptomatic term (40 years) since the ED was detected. A review of 18 reported cases of carcinoma in an ED indicated that advanced cancer has a poor prognosis. Periodic follow-up of ED patients is essential for early diagnosis.

    DOI: 10.1007/s12328-020-01098-4

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  • Real-world effectiveness and safety of tolvaptan in liver cirrhosis patients with hepatic edema: results from a post-marketing surveillance study (START study).

    Isao Sakaida, Shuji Terai, Masayuki Kurosaki, Mitsuru Okada, Takahiro Hirano, Yasuhiko Fukuta

    Journal of gastroenterology   55 ( 8 )   800 - 810   2020.8

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    BACKGROUND: This large-scale post-marketing surveillance study (START study) evaluated the effectiveness and safety of tolvaptan in Japanese liver cirrhosis patients with hepatic edema in real-world clinical settings. Here, we present the final analysis outcomes. METHODS: A prospective, multicenter, non-interventional study involving patients who received tolvaptan for the treatment of liver cirrhosis with hepatic edema with an insufficient response to conventional diuretics. The observation period was up to 6 months. Effectiveness evaluation included changes in body weight and clinical symptoms. Safety analysis included evaluation of adverse drug reactions (ADRs). RESULTS: Case reports of 1111 patients were collected. Of these, 1109 were included in the safety analysis and 1098 in the effectiveness analysis. The mean age was 69.4 ± 11.5 years and 695 (62.7%) patients were male. After tolvaptan treatment, a decrease in body weight from baseline was - 2.6 ± 2.7 kg on day 7 and - 3.8 ± 4.1 kg on day 14. Moreover, clinical symptoms significantly improved over the 14-day treatment. Frequently reported ADRs were thirst (6.6%), hepatic encephalopathy (2.3%), dehydration (1.5%), and hypernatremia (1.2%). A serum sodium level of ≥ 150 mEq/L was reported in five patients (0.5%). Multivariate analyses showed that the baseline blood urea nitrogen (BUN) level (cut-off value: 22.4 mg/dL) was the predictive factor for tolvaptan treatment response. CONCLUSIONS: The results suggest that tolvaptan was effective and well-tolerated in liver cirrhosis patients with hepatic edema. In the real-world clinical setting, tolvaptan provides a useful option for the treatment of hepatic edema.

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  • 側方発育型大腸腫瘍と肥満ならびに代謝指数に関する検討

    高綱 将史, 水野 研一, 川田 雄三, 冨永 顕太郎, 水澤 健, 佐藤 裕樹, 五十嵐 聡, 林 和直, 横山 純二, 橋本 哲, 寺井 崇二

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1332 - 1332   2020.8

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  • 【線維化 慢性疾患のキープロセス 多彩な間質細胞が織りなす組織リモデリング"fibrosis"の理解】(第3章)各臓器疾患における線維化 間葉系幹細胞投与による肝線維化改善、再生誘導効果

    寺井 崇二, 土屋 淳紀

    実験医学   38 ( 12 )   2059 - 2062   2020.8

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  • 当院におけるクローン病の患者に対する内視鏡的小腸結腸拡張術の臨床的検討

    富吉 圭, 川田 雄三, 冨永 顕太郎, 橋本 哲, 横山 純二, 寺井 崇二

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1332 - 1332   2020.8

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  • Changes in Magnetic Resonance Imaging Findings in a Malignant Melanoma Patient.

    Toru Setsu, Atsunori Tsuchiya, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 13 )   1671 - 1672   2020.7

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    DOI: 10.2169/internalmedicine.4263-19

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  • 三次リンパ組織の臓器普遍性の解明

    鳥生 直哉, 佐藤 有紀, 上村 博輝, 田中 真生, 寺井 崇二, 柳田 素子

    日本腎臓学会誌   62 ( 4 )   262 - 262   2020.7

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  • Rare case of circumferential esophageal peeling. Reviewed International journal

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Yui Ishii, Nobutaka Takeda, Kazuki Natsui, Yuzo Kawata, Naruhiro Kimura, Yoshihisa Arao, Suguru Takeuchi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    Clinical case reports   8 ( 7 )   1306 - 1308   2020.7

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    DOI: 10.1002/ccr3.2846

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  • Outcomes of EUS-guided choledochoduodenostomy as primary drainage for distal biliary obstruction with covered self-expandable metallic stents. International journal

    Naosuke Kuraoka, Kazuo Hara, Nozomi Okuno, Takamichi Kuwahara, Nobumasa Mizuno, Yasuhiro Shimizu, Yasumasa Niwa, Shuji Terai

    Endoscopy international open   8 ( 7 )   E861-E868   2020.7

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    Background and study aims  Endoscopic ultrasonography-guided choledochoduodenostomy (EUS-CDS) is an alternative therapy for percutaneous transhepatic biliary drainage. Outcomes of EUS-CDS for distal biliary tract obstruction with a covered self-expandable metallic stent (SEMS) as a primary drainage technique are unclear because there are few relevant reports. This study aimed to determine outcomes in patients undergoing EUS-CDS using SEMS as the primary drainage technique for malignant distal biliary duct obstruction. Patients and methods  This retrospective study was conducted at Aichi Cancer Center Hospital, from January 2010 to July 2018, using data from our database. Results  EUS-CDS was performed as a primary drainage technique for 92 patients. The technical success rate was 92.8 %, and the clinical success rate was 91.6 %. The overall incidence of adverse events was 15.7 %. The median stent patency time for the EUS-CDS was 396 days. Nineteen patients required re-intervention because of cholangitis or jaundice. Conclusion  EUS-CDS as a primary drainage technique using SEMS has high technical and clinical success rates. It should be considered an effective drainage method with respect to long-term stent patency, low re-intervention rates, and absence of severe complications.

    DOI: 10.1055/a-1161-8488

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  • 三次リンパ組織の臓器普遍性の解明

    鳥生 直哉, 佐藤 有紀, 上村 博輝, 田中 真生, 寺井 崇二, 柳田 素子

    日本腎臓学会誌   62 ( 4 )   262 - 262   2020.7

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  • 当院における心疾患に合併する遠隔期肝合併症における右心負荷系因子の重要性

    上村 博輝, 高村 昌昭, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A252 - A252   2020.7

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  • EUS-FNAが術前診断に有用であった十二指腸Brunner腺過誤腫出血の1切除例

    荒生 祥尚, 小林 正明, 池見 雅俊, 塩路 和彦, 清野 智, 阿部 寛幸, 岩城 孝和, 田口 貴博, 谷 優佑, 寺井 崇二

    Gastroenterological Endoscopy   62 ( 7 )   778 - 784   2020.7

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  • 肝胆膵疾患における血清DPPIV解析

    林 和直, 五十嵐 聡, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A387 - A387   2020.7

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  • オステオポンチン・脂肪酸・高トリグリセライド血症による膵癌高リスク患者の同定

    五十嵐 聡, 林 和直, 寺井 崇二

    膵臓   35 ( 3 )   A305 - A305   2020.7

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  • 膵癌早期発見を目指した新潟県膵癌ネットワーク(Phoenix Study)の構築と膵癌病態解析に関する多施設後方視的観察研究

    五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A258 - A258   2020.7

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  • 当院におけるIgG4関連硬化性胆管炎の診断の現状と課題

    田中 裕登, 林 和直, 五十嵐 聡, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A298 - A298   2020.7

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  • EUS-FNAが術前診断に有用であった十二指腸Brunner腺過誤腫出血の1切除例

    荒生 祥尚, 小林 正明, 池見 雅俊, 塩路 和彦, 清野 智, 阿部 寛幸, 岩城 孝和, 田口 貴博, 谷 優佑, 寺井 崇二

    Gastroenterological Endoscopy   62 ( 7 )   778 - 784   2020.7

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  • 消化器疾患における移植医療の現状と問題点 本県の急性肝不全診療におけるネットワーク構築の取り組み

    薛 徹, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A73 - A73   2020.7

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  • 肝硬変に対する間葉系幹細胞由来エクソソーム治療のライブイメージング技術、Single cell RNA-seqを用いたメカニズム解析

    土屋 淳紀, 竹内 卓, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A238 - A238   2020.7

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  • 肝硬変患者のQOL・予後の改善と基盤研究の最前線 IFN-γ刺激下間葉系幹細胞由来エクソソームの肝線維化改善における効果・メカニズムの検証

    土屋 淳紀, 竹内 卓, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A97 - A97   2020.7

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  • 胃瘻造設によりS状結腸間膜穿孔をきたした一例

    吉田 悠紀, 川田 雄三, 永山 逸夫, 野澤 良祐, 冨永 顕太郎, 薛 徹, 横尾 健, 水野 研一, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   36 ( 1 )   46 - 46   2020.7

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  • 肝癌治療に対する内科外科のすみわけと連携における放射線治療の役割

    上村 顕也, 柴田 理, 大越 麻理奈, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A292 - A292   2020.7

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  • 非アルコール性脂肪性肝疾患(NAFLD)の病態進行における自律神経を介した臓器間ネットワークの関与

    高 昌良, 上村 顕也, 名古屋 拓郎, 酒井 規裕, 坂牧 僚, 横尾 健, 寺井 崇二

    日本門脈圧亢進症学会雑誌   26 ( 2 )   143 - 146   2020.7

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  • 消化器疾患における共生微生物叢研究の新たな知見 NAFLDの病態における自律神経ネットワークを介した腸内細菌叢の関与

    高 昌良, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A78 - A78   2020.7

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  • 肝癌分子標的薬治療時の鰹だし併用による肝予備能維持効果

    小関 洋平, 上村 顕也, 坂牧 僚, 大越 麻理奈, 田中 裕登, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A296 - A296   2020.7

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  • 臨床応用に向けた肝癌の病態解明 放射線照射によるDNA損傷時のHHMの役割

    丹羽 佑輔, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   117 ( 臨増総会 )   A161 - A161   2020.7

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  • Cytapheresis for pyoderma gangrenosum associated with inflammatory bowel disease: A review of current status. Reviewed International journal

    Kentaro Tominaga, Kenya Kamimura, Hiroki Sato, Masayoshi Ko, Yuzo Kawata, Takeshi Mizusawa, Junji Yokoyama, Shuji Terai

    World journal of clinical cases   8 ( 11 )   2092 - 2101   2020.6

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    Pyoderma gangrenosum (PG) is a neutrophilic dermatosis clinically characterized by the presence of painful skin ulcerations with erythematous. As it is frequently associated with inflammatory bowel diseases, including ulcerative colitis, gastroenterologists should be familiar with the disease including therapeutic options. Therefore, we have conducted a review focusing on the cytapheresis for PG in cases of inflammatory bowel diseases. A literature search was conducted to extract studies published in the last 20 years, with information on demographics, clinical symptoms, treatment, and the clinical course from a total of 22 cases reported and our recent case. In most patients, cytapheresis was associated with improvement or resolution of PG after failure of conventional therapeutic options such as corticosteroids, antibiotics, immunosuppressive agents and immunoglobulin. Based on the information summarized, cytapheresis is helpful in the majority of patients with PG refractory to medical treatment associated with inflammatory bowel diseases and could be further studied in a multicenter, randomized trial.

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  • Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles. Reviewed International journal

    Takayuki Watanabe, Atsunori Tsuchiya, Suguru Takeuchi, Shunsuke Nojiri, Tomoaki Yoshida, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai

    Regenerative therapy   14   252 - 261   2020.6

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    Introduction: Currently, there are no approved drugs for treating non-alcoholic steatohepatitis (NASH); however, mesenchymal stem cells (MSCs) and their small extracellular vesicles (sEVs), which possess immunomodulatory activities, are potential candidates. This study aimed to develop a mouse model of NASH with rapid accumulation of fibrosis using the pre-established melanocortin type-4 receptor knockout (Mc4r-KO) NASH mouse model and lipopolysaccharide (LPS), and to evaluate the therapeutic effect of MSCs and their sEVs. Methods: Mc4r-KO mice (8 weeks old, male) were fed a western diet (WD) for 8 weeks. Next, the mice were intraperitoneally injected with lipopolysaccharide (LPS) twice a week for 4 weeks while continuing the WD. To confirm the therapeutic effect of MSCs and sEVs, human adipose tissue-derived MSCs or their sEVs were administered 12 weeks after initiation of the WD, and serum testing, quantitative analysis of fibrosis, and quantitative reverse transcription-polymerase chain reaction qRT-PCR were performed. Results: By providing a WD combined with LPS treatment, we successfully developed a NASH model with rapid accumulation of fibrosis. Both human MSCs and their sEVs decreased serum alanine transaminase levels and inflammatory markers based on qRT-PCR. Histological analysis showed that MSC or sEV treatment did not affect fat accumulation. However, an improvement in fibrosis in the groups treated with MSCs and their sEVs was observed. Furthermore, after administering MSCs and sEVs, there was a significant increase in anti-inflammatory macrophages in the liver. Conclusion: We successfully developed a NASH model with rapid accumulation of fibrosis and confirmed the anti-inflammatory and anti-fibrotic effects of MSCs and their sEVs, which may be options for future therapy.

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  • A rare case of peliosis hepatis in a patient with chronic renal failure and renal cell carcinoma.

    Hiroki Maruyama, Kazuya Takahashi, Natsuki Ishikawa, Kazunori Hosaka, Daisuke Kumaki, Yukio Aruga, Masashi Yamakawa, Masaaki Hirano, Kazuhiro Funakoshi, Shuji Terai

    Clinical journal of gastroenterology   13 ( 3 )   403 - 407   2020.6

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    Peliosis hepatis (PH) is a rare disease characterized by the presence of sinusoidal dilation and blood-filled cysts throughout the hepatic parenchyma. We report a case of PH in a 49-year-old woman with chronic renal failure (CRF) on hemodialysis and with renal cell carcinoma (RCC). Dynamic contrast-enhanced computed tomography (CT) showed a 35-mm-diameter, hypervascular tumor in the liver and RCC in the right renal cyst. Ultrasound and superparamagnetic iron oxide-enhanced magnetic resonance imaging were also performed; however, the liver tumor could not be distinguished from the metastasis of RCC. Therefore, echo-guided biopsy of the liver tumor using an 18-G Majima needle was performed. Histological evaluation of the specimen showed irregular sinusoidal dilatation and blood-filled cavities without malignant cells. She was ultimately diagnosed with PH. Subsequently, she underwent total right nephrectomy for RCC and was diagnosed with RCC stage 1 (pT1N0M0). A follow-up CT performed 4 months after nephrectomy showed no growth of PH. Although the development of PH in patients with CRF or RCC who do not undergo renal transplantation is extremely rare, it should be considered in the differential diagnosis to distinguish PH from the metastasis of RCC.

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  • 【幹細胞治療と疾患】間葉系幹細胞は"指揮細胞"としてマクロファージに作用し肝硬変の肝線維化改善、再生を誘導する 自己骨髄細胞投与療法から他家脂肪組織由来間葉系幹細胞投与へ

    寺井 崇二, 土屋 淳紀

    BIO Clinica   35 ( 5 )   406 - 410   2020.5

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  • Small Intestinal Bacterial Overgrowth Diagnosed by a Breath Test and Improved by Rifaximin in a Patient with Hepatic Encephalopathy and Alcoholic Liver Cirrhosis: A Case Report. Reviewed

    Akira Sakamaki, Kunihiko Yokoyama, Fusako Yamazaki, Hiroteru Kamimura, Kenya Kamimura, Masaaki Takamura, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 15 )   1849 - 1853   2020.4

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    A 66-year-old Japanese man was admitted to our hospital with grade 2 hepatic encephalopathy (HE). Abdominal computed tomography and laboratory examinations revealed decompensated liver cirrhosis. Intravenous administration of branched-chain amino acids immediately ameliorated the HE, and lactulose was initiated. However, a breath test revealed small intestinal bacterial overgrowth (SIBO); therefore, rifaximin was additionally initiated. The breath test was repeated after discharge, when no evidence of SIBO or overt HE was identified. This case suggested that a breath test is effective for the identification of SIBO and that the administration of a poorly absorbed antibiotic should be considered in SIBO-positive HE patients taking lactulose.

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  • Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice. Reviewed International journal

    Yoshihisa Arao, Hirokazu Kawai, Kenya Kamimura, Takamasa Kobayashi, Oki Nakano, Manabu Hayatsu, Tatsuo Ushiki, Shuji Terai

    Biochemical and biophysical research communications   527 ( 2 )   365 - 371   2020.4

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    Considering the increase in cases of non-alcoholic steatohepatitis (NASH), the use of appropriate animal model of NASH is essential to understand the underlying pathogenesis mechanism. To date, several mice models have been used; however, significant differences in the etiologies and food administered affected the results, with inconsistent conclusions. Therefore, it is necessary to understand these models and their differences to be able to choose appropriate models. Inspired by the fact that mitochondrial (mt)DNA content is changed in non-alcoholic fatty liver disease in humans, we investigated the mtDNA copy number in the NASH mice models induced by high-fat diet (HFD) and methionine/choline-deficient diet (MCD) to understand the differences between these models. Megamitochondria were observed in both MCD and HFD groups. However, the MCD group showed significant decrease in liver mtDNA content compared with that in the HFD group. These changes were associated with significant upregulation of mitochondrial biogenesis- and degradation-related genes in MCD model than in HFD model. Thus, stability of mtDNA is associated with the differences between MCD and HFD-induced NASH models often used in studies; these findings could help in choosing appropriate models for studies on NASH.

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  • Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis. Reviewed

    Kei Tomiyoshi, Hiroki Sato, Kentaro Tominaga, Yuzo Kawata, Daisuke Okamoto, Yoichi Kakuta, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 13 )   1611 - 1613   2020.4

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    Thiopurine drugs are commonly used to treat immunologic diseases. However, the narrow therapeutic safety margin demands evidence-based precision medicine approaches. NUDT15 variants are associated with thiopurine-induced adverse events, particularly in Asians. We herein report a rare genotype of His/His in NUDT15 codon 139 in a case of ulcerative colitis and review the relevant literature. The patient experienced severe thiopurine-associated adverse events, including leukopenia and alopecia. There is no literature on the His/His genotype in NUDT15 codon 139, and our case suggests cautious use or the contraindication of thiopurines for patients with this genotype.

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  • 新潟県における肝炎対策 Reviewed

    荒生 祥尚, 菊田 玲, 渡辺 和仁, 中山 均, 田村 務, 薛 徹, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A263 - A263   2020.4

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  • 当院における肝炎医療コーディネーターの取り組みと今後の課題 Reviewed

    廣川 光, 薛 徹, 荒生 祥尚, 澤栗 裕美, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A246 - A246   2020.4

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  • Huge liver tumor in young man. Reviewed International journal

    Osamu Shibata, Kenya Kamimura, Rie Azumi, Kei Shibuya, Shintaro Shiba, Tatsuya Ohno, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   4 ( 2 )   301 - 302   2020.4

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    Intrahepatic cholangiocarcinoma is the second leading primary hepatic tumors, accounting for 5% of all hepatic tumors. The curability depends on the operability; however, the difficulty of early diagnosis and late clinical presentation account for the poor prognosis. Therefore, development of a novel therapeutic option and a method to determine the viability of the primary tumor, which hinder the assessment of the impact of other therapies, including chemotherapy and radiotherapy are needed. Although FDG-PET has been used to detect distant metastases of ICC, which are present in 20% of patients at the initial diagnosis, little is known about the efficacy of FDG-PET of the primary lesion of ICC. Here, we present the case of a 31-year-old male diagnosed with unresectable ICC and successfully treated with carbon-ion radiation, and present the usefulness of fluorodeoxyglucose-positron emission tomography in the determination of the viability of the tumor.

    DOI: 10.1002/jgh3.12234

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  • Hypereosinophilia-related liver pseudotumor with elevated interleukin-5 levels preceding T-cell lymphoma. International journal

    Atsunori Tsuchiya, Tomoyuki Tanaka, Yasuhiko Shibasaki, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   4 ( 2 )   312 - 314   2020.4

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    A 61-year-old woman with hypereosinophilia and elevated interleukin (IL)-5 level was admitted to our hospital after detection of multiple liver tumors. Liver biopsy demonstrated that the tumor consisted of scar tissue with remnants of eosinophilic infiltration, suggesting that it had formed by massive eosinophilic infiltration. The hypereosinophilia was treated mainly by prednisolone, and thereafter, the liver tumors disappeared. However, 10 months postadmission, CD4+ T-cell lymphoma, which can produce IL-5, was detected in the nasopharynx and oropharynx. Therefore, we believe that this is a rare case of hypereosinophilia-related liver pseudotumor induced by presumed by IL-5 elevation.

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  • 自己免疫性肝炎における赤血球容量粒度分布幅変動係数の臨床的意義

    高村 昌昭, 高綱 将史, 薛 徹, 上村 博輝, 土屋 淳紀, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A433 - A433   2020.4

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  • 肝疾患における移行期医療 小児NAFLD患者の背景疾患と移行医療への課題

    上村 博輝, 上村 顕也, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A142 - A142   2020.4

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  • 肝移植医療における内科・外科連携の現状と問題点 本県における急性肝不全に対する肝移植再開に向けた診療ネットワーク運用の検討

    薛 徹, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A125 - A125   2020.4

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  • 門脈圧亢進症の診断と治療 原発性胆汁性胆管炎における食道静脈瘤発生の検討

    薛 徹, 横山 純二, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A151 - A151   2020.4

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  • NAFLDの病態解明及び新規治療法の探索 非アルコール性脂肪性肝炎(NASH)モデルマウスを用いたスフィンゴシン1リン酸受容体ブロックによる脂質構成の変化と発癌機構の解明

    吉田 智彰, 土屋 淳紀, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A215 - A215   2020.4

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  • 肝硬変の予後改善を目指した治療戦略 肝硬変に対する間葉系幹細胞由来のエクソソーム療法の開発に向けて

    土屋 淳紀, 竹内 卓, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A92 - A92   2020.4

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  • 生体試料を用いた研究の最前線 間葉系幹細胞のエクソソームによる肝線維化改善抗炎症性マクロファージ誘導法の開発

    竹内 卓, 土屋 淳紀, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A33 - A33   2020.4

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  • 健診での生活歴から考察したNAFLD症例に対する新しい生活指導法の提案

    横尾 健, 中野 応央樹, 佐藤 公俊, 冨永 顕太郎, 橋本 哲, 高村 昌昭, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A454 - A454   2020.4

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  • 肝発癌進展研究の最前線 肝発癌,治療抵抗性にかかわるHHM遺伝子のDNA損傷応答メカニズムの解析

    上村 顕也, 丹羽 佑輔, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A44 - A44   2020.4

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  • 臓器間ネットワークと肝疾患 自律神経経路を介する肝-脳-消化管軸の非アルコール性脂肪肝炎の病態への関与

    上村 顕也, 大脇 崇史, 寺井 崇二

    肝臓   61 ( Suppl.1 )   A182 - A182   2020.4

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  • An unusual case of esophageal motility disorder. Reviewed International journal

    Youhei Koseki, Hiroki Sato, Shuji Terai

    Gastroenterology   159 ( 3 )   838 - 841   2020.3

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    DOI: 10.1053/j.gastro.2020.03.032

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  • Secondary Achalasia in Myotonic Dystrophy May Have a Different Pathology and Management. Reviewed

    Hiroki Sato, Ken-Ichi Mizuno, Satoru Hashimoto, Masafumi Takatsuna, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 6 )   875 - 875   2020.3

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  • Variations of small bowel transit time on capsule endoscopy Reviewed International journal

    Tominaga K, Sato H, Yokomichi H, Tsuchiya A, Yoshida T, Kawata Y, Yokoyama J, Terai S

    Annals of Translational Medicine   in Press ( 6 )   348 - 348   2020.3

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    Background: Small bowel motility remains inadequately understood because of the complex and various functions as well as its anatomical position. The aimed of the study was to investigate the small bowel transit time (SBTT) of capsule endoscopy (CE) and to analyze the clinical factors affecting SBTT. Methods: SBTT was analyzed in patients who underwent small bowel CE. Factors contributing to SBTT and CE retention were investigated. Results: Among 397 patients enrolled in this study, 336 (84.6%) completed CE. The mean SBTT (± standard deviation) was 282.1±132.2 min. According to the univariate and multivariate analyses, aging and small bowel stenosis extended SBTT. In 38 patients who underwent multiple CE studies, considerable variation in SBTT were observed [mean of standard deviations (SDs) =97.97 min, SD of the SDs =81.99 min]. CE retention was observed in 61 patients (13.3%), and it was statistically associated to small bowel lesion. Conclusions: Aging and small bowel stenosis were associated with longer SBTT. Furthermore, SBTT analyzed by CE should be interpreted carefully considering the intra-individual differences in SBTT.

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  • Rare gastric outlet obstruction owing to ectopic pancreas: a case report and literature review. International journal

    Kunihiko Yokoyama, Hiroki Sato, Yuichi Sato, Jun Watanabe, Atsuo Nakamura, Shuji Terai

    Annals of translational medicine   8 ( 5 )   252 - 252   2020.3

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    The ectopic pancreas is often observed in the gastrointestinal tract, and is typically asymptomatic. A 28-year-old woman was referred to our hospital following repeated vomiting after every meal. Following gastroscopy, contrast-enhanced computed tomography (CE-CT), and endoscopic ultrasonography (EUS), she was diagnosed with gastric outlet obstruction, also known as pyloric obstruction, caused by a giant submucosal cystic tumor. The condition was successfully treated with EUS-guided cystic drainage, and she was diagnosed with a cystic tumor originating from the ectopic pancreas. The tumor shrank following EUS-guided cystic drainage, and her obstructive symptoms resolved. In cases with overgrowth of the ectopic pancreas, the differential diagnosis of malignancy is important but challenging. Herein, we report a unique final pathology of this rare case and discuss the findings with a literature review.

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  • Percutaneous Gastrojejunostomy Catheter Placement Using a Slow-Leak Balloon through the Reconstructed Gastric Tube after Esophagectomy. International journal

    Shinichi Morita, Yasuaki Arai, Shunsuke Sugawara, Miyuki Sone, Koji Tomita, Hiroaki Ishii, Shuji Terai

    Journal of vascular and interventional radiology : JVIR   31 ( 3 )   478 - 481   2020.3

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    Twelve patients who had undergone esophageal reconstruction because of cancer and in whom conventional percutaneous radiologic or endoscopic gastrostomy was considered difficult are reported. These patients underwent placement of a percutaneous gastrojejunostomy catheter through the reconstructed gastric tube using a slow-leak balloon that had been developed for percutaneous transesophageal gastrotubing. Retrospective evaluation showed successful outcomes without severe complications in all patients. Eight (66.6%) were able to resume oral intake, which allowed gastrojejunostomy catheter withdrawal in 3 (25%). This technique is feasible with acceptable clinical outcomes for patients who have undergone gastric tube reconstruction after esophagectomy.

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  • 肝悪性腫瘍との鑑別に苦慮した原発性肝放線菌症の1例

    本田 博樹, 野澤 優次郎, 高村 昌昭, 上村 博輝, 土屋 淳紀, 寺井 崇二

    肝臓   61 ( 3 )   109 - 115   2020.3

  • 【間葉系幹細胞の基礎と臨床応用】疾患治療 他家脂肪組織由来間葉系幹細胞投与療法の開発

    寺井 崇二, 土屋 淳紀

    医学のあゆみ   272 ( 10 )   1032 - 1039   2020.3

  • Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma. Reviewed International journal

    Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Norihiro Sakai, Takuro Nagoya, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Akira Sakamaki, Hiroteru Kamimura, Norio Miyamura, Hiroshi Nishina, Shuji Terai

    Cancers   12 ( 2 )   2020.2

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    Hepatocellular carcinoma (HCC) is a major global malignancy, responsible for >90% of primary liver cancers. Currently available therapeutic options have poor performances due to the highly heterogeneous nature of the tumor cells; recurrence is highly probable, and some patients develop resistances to the therapies. Accordingly, the development of a novel therapy is essential. We assessed gene therapy for HCC using a diphtheria toxin fragment A (DTA) gene-expressing plasmid, utilizing a non-viral hydrodynamics-based procedure. The antitumor effect of DTA expression in HCC cell lines (and alpha-fetoprotein (AFP) promoter selectivity) is assessed in vitro by examining HCC cell growth. Moreover, the effect and safety of the AFP promoter-selective DTA expression was examined in vivo using an HCC mice model established by the hydrodynamic gene delivery of the yes-associated protein (YAP)-expressing plasmid. The protein synthesis in DTA transfected cells is inhibited by the disappearance of tdTomato and GFP expression co-transfected upon the delivery of the DTA plasmid; the HCC cell growth is inhibited by the expression of DTA in HCC cells in an AFP promoter-selective manner. A significant inhibition of HCC occurrence and the suppression of the tumor marker of AFP and des-gamma-carboxy prothrombin can be seen in mice groups treated with hydrodynamic gene delivery of DTA, both 0 and 2 months after the YAP gene delivery. These results suggest that DTA gene therapy is effective for HCC.

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  • On-line HDFを急性肝不全の患者に施行する際の診療ガイド

    井上 和明, 織田 成人, 安部 隆三, 滝川 康裕, 中山 伸朗, 加藤 直也, 藤原 慶一, 安井 伸, 寺井 崇二, 井戸 章雄, 坂井田 功, 玄田 拓哉, 清水 雅仁, 持田 智, 滝川 一

    肝臓   61 ( 2 )   47 - 60   2020.2

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  • Septicemic listeriosis during adalimumab- and golimumab-based treatment for ulcerative colitis: case presentation and literature review. Reviewed

    Ryoko Horigome, Hiroki Sato, Terasu Honma, Shuji Terai

    Clinical journal of gastroenterology   13 ( 1 )   22 - 25   2020.2

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    Listeria monocytogenes is a common bacterium that can trigger an episode of amphixenosis from the consumption of contaminated food. It survives in the host as an intracellular parasite and can get reactivated when the host's immune system is compromised. The use of anti-tumor necrosis factor-α (TNF-α) blockers is reported to increase the risk of L. monocytogenes infections. In the field of gastroenterology, the use of TNF-α blockers is on the rise due to remarkable efficacy in select patients with inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn's disease and the rise in the incidence and prevalence of IBDs. There are few case reports on this topic, despite the rapid development of novel TNF-α blockers. Here, we report two cases of septicemic listeriosis encountered during treatment with the more recent TNF-α blockers, namely, adalimumab and golimumab, in ulcerative colitis and review the published literature on the topic.

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  • Rare paradoxical adverse event in Crohn's disease: a case report. Reviewed International journal

    Marina Okoshi, Hiroki Sato, Terasu Honma, Shuji Terai

    Annals of translational medicine   8 ( 4 )   133 - 133   2020.2

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    An 18-year-old male adolescent diagnosed with ileocolitis-type Crohn's disease received therapy involving an anti-tumor necrosis factor-α (TNF-α) blocker, which resulted in remission for 2 years. The patient presented with fever, stomatitis, and cough with respiratory distress. Chest radiography revealed bilateral hilar lymphadenopathy; bronchoalveolar lavage showed high lymphocyte level: 40.8% and CD4/8 value: 3.9. Transbronchial lung biopsy identified multiple non-caseating granulomas fused to each other with connective tissue septa, leading to the diagnosis of sarcoidosis. The sarcoidosis was defined as a paradoxical adverse event (PAE) due to the use of TNF-α blocker; therefore, cessation of TNF-α blocker administration was sufficient to induce remission. We report a rare case of PAE on Crohn's disease. The characteristics and distinguishing histologies of PAE and Crohn's disease are described. Biological agent therapy has been reported to cause several PAEs during the treatment of immune-mediated inflammatory disorders. PAEs are defined as pathological conditions that occur during biological agent therapy usually effective in treatment. The laboratory, radiography, and histological findings shown in this case are useful for differential diagnosis and management of PAE.

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  • 肝癌に対する局所療法としての放射線療法の安全性と有効性の検証

    大越 麻理奈, 上村 顕也, 柴田 修, 森田 慎一, 坂牧 僚, 田中 裕登, 小関 洋平, 寺井 崇二

    日本内科学会雑誌   109 ( Suppl. )   155 - 155   2020.2

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  • Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease. Reviewed International journal

    Takuro Nagoya, Kenya Kamimura, Ryosuke Inoue, Masayoshi Ko, Takashi Owaki, Yusuke Niwa, Norihiro Sakai, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Yuka Nakamura, Masaki Ueno, Shuji Terai

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society   32 ( 5 )   e13799   2020.1

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    BACKGROUND: The correlation of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) with non-alcoholic fatty liver disease (NAFLD) has been reported in epidemiological studies. However, the mechanisms of molecular and inter-organ systems that render these factors to influence on NAFLD have not been elucidated. In this study, we examined the induction of ghrelin which is the GH-releasing hormone and IGF-1, and involvement of autonomic neural circuits, in the pathogenesis of NAFLD. METHODS: The expression of gastric and hypothalamic ghrelin, neural activation in the brain, and serum IGF-1 were examined in NAFLD models of choline-deficient defined l-amino-acid diet-fed, melanocortin 4 receptor knockout mice, and partial hepatectomy mice with or without the blockades of autonomic nerves to test the contribution of neural circuits connecting the brain, liver, and stomach. KEY RESULTS: The fatty changes in the liver increased the expression of gastric ghrelin through the autonomic pathways which sends the neural signals to the arcuate nucleus in the hypothalamus through the afferent vagal nerve which reached the pituitary gland to release GH and then stimulate the IGF-1 release from the liver. In addition, high levels of ghrelin expression in the arcuate nucleus were correlated with NAFLD progression regardless of the circuits. CONCLUSIONS: Our study demonstrated that the fatty liver stimulates the autonomic nervous signal circuits which suppress the progression of the disease by activating the gastric ghrelin expression, the neural signal transduction in the brain, and the release of IGF-1 from the liver.

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  • Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Reviewed International journal

    Erika Ishihara, Yuya Nagaoka, Toshiaki Okuno, Satoshi Kofuji, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Kenya Kamimura, Shuji Terai, Takehiko Yokomizo, Yukihiko Sugimoto, Yasuyuki Fujita, Akira Suzuki, Hiroshi Nishina

    Genes to cells : devoted to molecular & cellular mechanisms   25 ( 3 )   197 - 214   2020.1

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    Cell competition is a biological process by which unfit cells are eliminated from "cell society." We previously showed that cultured mammalian epithelial Madin-Darby canine kidney (MDCK) cells expressing constitutively active YAP were eliminated by apical extrusion when surrounded by "normal" MDCK cells. However, the molecular mechanism underlying the elimination of active YAP-expressing cells was unknown. Here, we used high-throughput chemical compound screening to identify cyclooxygenase-2 (COX-2) as a key molecule triggering cell competition. Our work shows that COX-2-mediated PGE2 secretion engages its receptor EP2 on abnormal and nearby normal cells. This engagement of EP2 triggers downstream signaling via an adenylyl cyclase-cyclic AMP-PKA pathway that, in the presence of active YAP, induces E-cadherin internalization leading to apical extrusion. Thus, COX-2-induced PGE2 appears a warning signal to both abnormal and surrounding normal cells to drive cell competition.

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  • Usefulness of autotaxin for the complications of liver cirrhosis. International journal

    Xue Shao, Haruki Uojima, Toru Setsu, Tomomi Okubo, Masanori Atsukawa, Yoshihiro Furuichi, Yoshitaka Arase, Hisashi Hidaka, Yoshiaki Tanaka, Takahide Nakazawa, Makoto Kako, Tatehiro Kagawa, Katsuhiko Iwakiri, Shuji Terai, Wasaburo Koizumi

    World journal of gastroenterology   26 ( 1 )   97 - 108   2020.1

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    BACKGROUND: Autotaxin (ATX) has been reported as a direct biomarker for estimating the evaluation of liver fibrosis. But available data on ATX as a useful biomarker for the complications of liver cirrhosis (LC) are scant. AIM: To assess the clinical usefulness of ATX for assessing the complications of LC. METHODS: This multicenter, retrospective study was conducted at six locations in Japan. We include patients with LC, n = 400. The ATX level was evaluated separately in men and women because of its high level in female patients. To assess the clinical usefulness of ATX for the complications of LC, the area under the curve (AUC) of ATX assessing for the severe complications was analyzed in comparison with the model for end-stage liver disease score, albumin-bilirubin (ALBI) score, fibrosis-4 index, and aspartate aminotransferase-to-platelet ratio index. RESULTS: The mean age was 68.4 ± 11.4 years, 240 patients (60.0%) were male. A total of 213 (53.3%) and 187 (46.8%) patients were compensated and decompensated, respectively. The numbers of patients with varix rupture, hepatic ascites, and hepatic encephalopathy were 35 (8.8%), 131 (32.8%), and 103 (25.8%), respectively. The AUCs of ATX in men for hepatic encephalopathy, hepatic ascites, and varix ruptures were 0.853, 0.816, and 0.706, respectively. The AUCs of ATX in women for hepatic encephalopathy, hepatic ascites, and varix rupture were 0.759, 0.717, and 0.697, respectively. The AUCs of ATX in men were higher than those in women, as were all the other biomarkers used to detect encephalopathy and varix ruptures. However, for detecting ascites, the AUC of ALBI in men was more effective than using ATX. CONCLUSION: ATX in men was more effective than any other biomarkers for detecting hepatic encephalopathy and varix ruptures.

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  • Achalasia in a Patient with Myotonic Dystrophy. Reviewed

    Hiroki Sato, Ken-Ichi Mizuno, Satoru Hashimoto, Masafumi Takatsuna, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 1 )   67 - 68   2020.1

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    Myotonic dystrophy is a progressive disorder mainly affecting the voluntary muscles. We herein report a rare case of myotonic dystrophy complicated with high-resolution manometry-defined achalasia, the pathology of which is absent relaxation of the smooth muscles of lower esophageal sphincter (LES). In the present case, achalasia was considered a complication of myotonic dystrophy instead of sporadic achalasia, as on performing high-resolution manometry, the finding of an impaired LES relaxation (myotonic phase) changed to a totally emaciated LES function (muscle weakness phase) as myotonic dystrophy progressed.

    DOI: 10.2169/internalmedicine.3360-19

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  • Rare Brain Metastasis From a Pancreatobiliary Subtype of Intraductal Papillary Mucinous Neoplasm. Reviewed International journal

    Arao Y, Kamimura K, Ikemi M, Hayashi K, Takaki M, Takahashi S, Seino S, Abe H, Tsuboguchi S, Otsu Y, Sanpei K, Kohisa J, Kondo S, Tani Y, Ito J, Toyoshima Y, Kakita A, Ajioka Y, Terai S

    Pancreas   49 ( 1 )   e8 - e11   2020.1

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  • Endoscopic diverticulectomy for Zenker's diverticulum with heterotopic gastric mucosa. Reviewed International journal

    Hiroki Sato, Manabu Takeuchi, Shuji Terai

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   32 ( 1 )   145 - 145   2020.1

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    DOI: 10.1111/den.13529

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  • Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. International journal

    Shun-Saku Takahashi, Yu-Shin Sou, Tetsuya Saito, Akiko Kuma, Takayuki Yabe, Yuki Sugiura, Hyeon-Cheol Lee, Makoto Suematsu, Takehiko Yokomizo, Masato Koike, Shuji Terai, Noboru Mizushima, Satoshi Waguri, Masaaki Komatsu

    Life science alliance   3 ( 1 )   2020.1

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    Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis, but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, accumulates because of autophagy suppression, LDs decrease in size and number. Ablation of ATG7, a gene essential for autophagy, suppressed the expression of gene targets of liver X receptor α, a nuclear receptor responsible for fatty acid and triglyceride synthesis in an NCoR1-dependent manner. LD accumulation in response to fasting and after hepatectomy was hampered by the suppression of autophagy. These results suggest that autophagy controls physiological hepatosteatosis by fine-tuning NCoR1 protein levels.

    DOI: 10.26508/lsa.201900513

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  • Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases. Reviewed International journal

    Atsunori Tsuchiya, Suguru Takeuchi, Takahiro Iwasawa, Masaru Kumagai, Takeki Sato, Satoko Motegi, Yui Ishii, Youhei Koseki, Kei Tomiyoshi, Kazuki Natsui, Nobutaka Takeda, Yuki Yoshida, Fusako Yamazaki, Yuichi Kojima, Yusuke Watanabe, Naruhiro Kimura, Kentaro Tominaga, Hiroteru Kamimura, Masaaki Takamura, Shuji Terai

    Inflammation and regeneration   40   14 - 14   2020

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    The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has had global effects such as activity restriction, economic stagnation, and collapse of healthcare infrastructure. Severe SARS-CoV-2 infection induces a cytokine storm, leading to acute respiratory distress syndrome (ARDS) and multiple organ failure, which are very serious health conditions and must be mitigated or resolved as soon as possible. Mesenchymal stem cells (MSCs) and their exosomes can affect immune cells by inducing anti-inflammatory macrophages, regulatory T and B cells, and regulatory dendritic cells, and can inactivate T cells. Hence, they are potential candidate agents for treatment of severe cases of COVID-19. In this review, we report the background of severe cases of COVID-19, basic aspects and mechanisms of action of MSCs and their exosomes, and discuss basic and clinical studies based on MSCs and exosomes for influenza-induced ARDS. Finally, we report the potential of MSC and exosome therapy in severe cases of COVID-19 in recently initiated or planned clinical trials of MSCs (33 trials) and exosomes (1 trial) registered in 13 countries on ClinicalTrials.gov.

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  • Ten years' experience in Niigata Prefecture Liver Disease Consultation Center Reviewed

    Kamimura Hiroteru, Takamura Masaaki, Ikarashi Masato, Aoyagi Yutaka, Kikuta Rei, Watanabe Kazuhito, Nakayama Hitoshi, Tamura Tsutomu, Terai Shuji, Setsu Toru, Arao Yoshihisa, Hirokawa Hikaru, Sawaguri Hiromi, Watanabe Fumiko, Komoro Yuko, Sakamaki Akira, Tsuchiya Atsunori

    Kanzo   61 ( 5 )   245 - 254   2020

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    <p>Niigata University Hospital Center for Liver Diseases was established in 2009, following a notice issued in 2007 aimed at developing the care system for liver diseases. The center provides proper medical information to increase awareness on hepatitis C (HCV) and manages the medical expense subsidy system for viral hepatitis in Niigata Prefecture. The center cooperates with national government organizations and publishes an annual report on viral hepatitis in Niigata Prefecture. Additionally, the center works towards viral hepatitis eradication but employs strategies based on local settings because of a lack of doctors. A large number of Japanese citizens have not been tested for hepatitis C. Furthermore, the hepatitis E, hepatitis A and drug-resistant hepatitis B virus must be carefully monitored. The center, therefore, plays an important role in terms of providing citizens with a good healthcare environment through various medical expense support systems related to liver cancer and liver cirrhosis.</p>

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  • Obesity and accumulation of subcutaneous adipose tissue are poor prognostic factors in patients with alcoholic liver cirrhosis. International journal

    Akira Sakamaki, Kunihiko Yokoyama, Kyutaro Koyama, Shinichi Morita, Hiroyuki Abe, Kenya Kamimura, Masaaki Takamura, Shuji Terai

    PloS one   15 ( 11 )   e0242582   2020

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    In alcoholic liver cirrhosis (LC) patients, obesity has become a problem that progresses into liver dysfunction. Herein, we investigated the relationship between the prognosis of steatohepatitis and body weight, along with fat accumulation in patients with alcoholic LC. We conducted a single-center retrospective study, enrolled 104 alcoholic LC patients without hepatocellular carcinoma (HCC) based on histological and clinical evidence, and investigated factors related to poor prognosis using multivariate Cox regression and cluster analyses. Cox regression analysis revealed three independent relevant factors: subcutaneous adipose tissue (SAT) index (median 34.8 cm2/m2, P = 0.009, hazard ratio [HR] 1.017, 95% confidence interval [CI] 1.004-1.030), total bilirubin level (median 1.7 mg/dL, P = 0.003, HR 1.129, 95% CI 1.042-1.223), and prothrombin time value (median 64%, P = 0.007, HR 0.967, 95% CI 0.943-0.991). In the cluster analysis, we categorized the patients into three groups: no adipose tissue accumulation (NAT group), SAT prior accumulation (SAT group), and visceral adipose tissue prior accumulation (VAT group). The results of the three groups revealed that the SAT group displayed a significantly poor prognosis of the Kaplan-Meier curve (67.1 vs 21.2 vs 65.3, P<0.001) of a 5-year survival rate. Propensity score matching analysis of the SAT and VAT groups was performed to adjust the patient's background, but no significant differences were found between them; however, the prognosis was poorer (21.2 vs 66.3, P<0.001), and hemostatic factors were still at a lower level in the SAT group. These findings suggest that SAT accumulation type of obesity is a poor prognostic factor in alcoholic LC patients without HCC, and the hemorrhagic tendency might worsen the poor prognosis in such cases.

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  • Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016

    Masamune, A., Kikuta, K., Hamada, S., Tsuji, I., Takeyama, Y., Shimosegawa, T., Okazaki, K., Kanno, A., Sano, T., Uchida, K., Ikeura, T., Fujimori, N., Nakai, Y., Kamisawa, T., Kubota, K., Motoya, M., Shimizu, K., Ushijima, T., Fukasawa, M., Naitoh, I., Ueno, M., Okuwaki, K., Uza, N., Asada, M., Mukai, T., Kudo, Y., Uetsuki, K., Mitoro, A., Watanabe, H., Terai, S., Hayashi, K., Imamura, Y., Haba, S., Hara, K., Fujisawa, T., Iwasaki, E., Okumura, F., Kawaji, Y., Kitano, M., Nishino, T., Nagahama, M., Hirano, A., Aruga, Y., Yamamoto, S., Inui, K., Kubota, Y., Takahashi, K., Sakagami, J., Kobayashi, T., Miraki, T., Watanabe, T., Sato, H., Takeda, Y., Satoh, M., Kobashigawa, K., Chiba, M., Tamura, T., Sawada, N., Mizukami, K., Sekine, M., Unno, J., Ishizawa, T., Funayama, H., Hatayama, K., Miyakawa, H., Sakai, T., Kuwatani, M., Toki, M., Toyokawa, T., Hashimoto, S., Itoi, T., Iwashita, Y., Sato, A., Kato, H., Takatori, H., Iizawa, Y., Iwashita, T., Kondo, H., Sato, Y., Tanabe, M., Ogura, T., Yamamoto, K., Masaka, T., Setsuda, M., Sano, T., Matsubara, S., Kitamura, K., Iwata, K., Shirahata, N., Hagiwara, H., Yoshida, M., Yokota, T., Shigoka, H., Kaneko, N., Abue, M., Tsuruoka, N.

    Journal of Gastroenterology   55 ( 4 )   2020

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  • Nationwide epidemiological survey of chronic pancreatitis in Japan: introduction and validation of the new Japanese diagnostic criteria 2019

    Masamune, A., Kikuta, K., Kume, K., Hamada, S., Tsuji, I., Takeyama, Y., Shimosegawa, T., Okazaki, K., Miura, S., Takikawa, T., Hongo, S., Nakano, E., Nabeshima, T., Matsumoto, R., Tanaka, Y., Ueno, M., Mukai, T., Matsumoto, M., Kudo, Y., Azuma, S., Okuwaki, K., Yamamoto, S., Inui, K., Kobashigawa, K., Unno, J., Fujimori, N., Kitamura, K., Miyakawa, H., Takahashi, K., Ikeura, T., Takenaka, M., Fukasawa, M., Funayama, H., Mitoro, A., Takagi, T., Sekine, M., Suwa, K., Sakagami, J., Ishida, M., Ohtsuka, M., Kagawa, S., Muraki, T., Watanabe, T., Watanabe, T., Yamamoto, K., Masaka, T., Nagahama, M., Sato, A., Aruga, Y., Nakai, Y., Iwasaki, E., Itoi, T., Kawaji, Y., Kitano, M., Mizukami, K., Iwasaki, S., Mori, M., Kaneko, N., Kodama, Y., Sato, H., Yoshida, N., Hatayama, K., Kobayashi, T., Hirano, A., Kaino, M., Fujisawa, T., Ushijima, T., Chiba, M., Shimizu, K., Ota, H., Toki, M., Nishikawa, T., Yoshida, Y., Tanaka, K., Uetsuki, K., Motoya, D., Muro, S., Watanabe, H., Imamura, Y., Ishizawa, T., Kamisawa, T., Tsuruoka, M., Hayashi, K., Terai, S., Iwatsuka, K., Iwata, K., Yoshida, M., Takagi, T., Goto, M., Oza, N., Takeda, Y., Hagiwara, H., Tadano, T., Sakai, T., Sumimoto, K., Nishimura, N., Irisawa, A., Kuwatani, M., Shirahata, N., Satoh, M., Fujikawa, T., Iizawa, Y., Watanabe, N., Ishiguro, H., Sawada, N., Katada, K., Kondo, H., Sakakihara, I., Nishida, J., Tamura, T., Dairaku, N., Kamezaki, H., Okano, H., Suzuki, S., Okamoto, T., Matsugu, Y., Imamura, M., Honjo, M., Sugiyama, G., Ohta, H., Higashide, S., Ishii, S., Hoshi, T., Takagi, Y., Satoh, A., Yamaji, N., Nishimura, N., Shibasaki, M., Tamura, H., Iwashita, T., Motoya, M., Tanisaka, Y., Ryozawa, S., Takatori, H., Tsuruoka, N., Hashimoto, S., Suzuki, N., Sato, Y., Tamai, H., Hara, K., Ashida, K., Yokota, T., Tsuji, T., Abue, M., Tomaki, H., Fukunishi, M., Koga, H., Takehara, Y., Kawamura, H., Shimokawahara, N., Otsu, N., Kimura, Y., Ishido, K., Kofunato, Y., Shiihara, M., Sakaguchi, T., Masui, T., Eguchi, H., Suzumura, K., Ide, T., Inomata, M., Maemura, K., Iizawa, H., Nakajima, A., Uyama, S., Shiozaki, S., Yokoyama, S., Wakabayashi, T., Furuuchi, T., Gushima, T., Satoh, S., Shioya, T., Nakazawa, K., Takahashi, Y., Fukuba, N., Matsubara, S.

    Journal of Gastroenterology   55 ( 11 )   2020

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  • Usefulness of endoscopic ultrasound (EUS)-fine needle aspiration (FNA) for local excision of brunner's gland hamartoma with hemorrhage: A case report and literature review,EUS-FNA が術前診断に有用であった十二指腸 Brunner 腺過誤腫出血の <sub>1</sub> 切除例

    Arao, Y., Kobayashi, M., Ikemi, M., Shioji, K., Seino, S., Abe, H., Iwaki, T., Taguchi, T., Tani, Y., Terai, S.

    Gastroenterological Endoscopy   62 ( 7 )   2020

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    DOI: 10.11280/gee.62.778

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  • Practical guide on on-line hemodiafiltration for acute liver failure

    Inoue, K., Oda, S., Abe, R., Takikawa, Y., Nakayama, N., Kato, N., Fujiwara, K., Yasui, S., Terai, S., Ido, A., Sakaida, I., Genda, T., Shimizu, M., Mochida, S., Takikawa, H.

    Kanzo/Acta Hepatologica Japonica   61 ( 2 )   2020

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    DOI: 10.2957/kanzo.61.47

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  • Clinical practice of acute pancreatitis in Japan: An analysis of nationwide epidemiological survey in 2016

    Masamune, A., Kikuta, K., Hamada, S., Tsuji, I., Takeyama, Y., Shimosegawa, T., Okazaki, K., Matsumoto, R., Kume, K., Miura, S., Takikawa, T., Hongo, S., Tanaka, Y., Sakai, T., Ueno, M., Unno, J., Toki, M., Nishimura, M., Kitamura, K., Kobashigawa, K., Ashida, K., Takahashi, K., Watanabe, T., Sato, Y., Satoh, A., Yoshida, N., Tanaka, K., Kondo, H., Suzuki, N., Sato, H., Mitoro, A., Minami, K., Iwasaki, E., Okuwaki, K., Mukai, T., Kudo, Y., Azuma, S., Takeda, Y., Setsuda, M., Tsuchida, K., Irisawa, A., Motoya, D., Shirahata, N., Iwata, K., Oza, N., Kawaguchi, Y., Hoshino, A., Hirano, A., Sakakihara, I., Watanabe, N., Funayama, H., Nakamura, Y., Yamamoto, T., Uchida, H.H., Iizawa, Y., Imamura, M., Sekine, M., Inui, K., Yamamoto, S., Sato, S., Ishii, S., Yakushijin, T., Yamamoto, K., Masaka, T., Yoshida, M., Arizumi, T., Goto, M., Takenaka, M., Miyakawa, H., Otsuka, Y., Nishi, M., Suwa, K., Sakagami, J., Satoh, M., Koga, H., Takagi, T., Nagahama, M., Hatayama, K., Kaneko, N., Mori, M., Nakai, Y., Iwashita, Y., Iwatsuka, K., Hayashi, K., Terai, S., Kaneto, H., Nishikawa, T., Uchi, M., Honjo, M., Takagi, T., Mizukami, K., Tamura, T., Gushima, T., Sato, A., Shimizu, K., Aruga, Y., Nonogaki, K., Kaino, M., Iwashita, T., Tsuruoka, M., Miura, M., Hasegawa, H., Takai, T., Yokota, H., Fujisawa, T., Uetsuki, K., Kobayashi, T., yamaji, N., Itoi, T., Muraki, T., Watanabe, T., Inatomi, O., Ushijima, T., Takehara, Y., Kawamura, H., Fukasawa, M., Hagiwara, H., Tamura, H., Moriya, T., Kuwatani, M., Kawaji, Y., Kamisawa, T., Abue, M., Fukunishi, M., Onoyama, H., Mochizuki, S., Sumimoto, K., Koyabu, M., Nishio, A., Sakao, M., Imamura, Y., Ohta, H., Nishimura, N., Shiihara, M., Anan, H., Motoya, M., Chiba, M., Deguchi, T., Kofunato, Y., Sawada, N., Katada, K., Matsumoto, S., Higashide, S., Okano, H., Ishida, M., Yamazaki, M., Tamura, N., Muraoka, T., Uza, N., Kodama, Y., Muro, S., Fujimori, N., Ikeda, T., Shimokawahara, N., Otsu, N., Yano, Y., Sugawara, S., Takaura, K., Ogura, Y., Furuuchi, T., Shibasaki, M., Kishimoto, M.

    Pancreatology   20 ( 4 )   2020

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  • A case of primary hepatic actinomycosis difficult to distinguish from malignant hepatic tumors

    Honda, H., Nozawa, Y., Takamura, M., Kamimura, H., Tsuchiya, A., Terai, S.

    Kanzo/Acta Hepatologica Japonica   61 ( 3 )   2020

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    DOI: 10.2957/kanzo.61.109

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  • Rare Mesenteric Arterial Diseases: Fibromuscular Dysplasia and Segmental Arterial Mediolysis and Literature Review. Reviewed

    Masayoshi Ko, Kenya Kamimura, Akira Sakamaki, Yusuke Niwa, Kentaro Tominaga, Kenichi Mizuno, Shuji Terai

    Internal medicine (Tokyo, Japan)   58 ( 23 )   3393 - 3400   2019.12

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    Fibromuscular dysplasia (FMD) and segmental arterial mediolysis (SAM) are noninflammatory, nonatherosclerotic arterial diseases that cause aneurysm, occlusion, and thromboses. These diseases are rarely seen in mesenteric arterial lesions; however, as they can be lethal if appropriate management is not provided, the accumulation of clinical information from cases is essential. We herein report the cases of a 57-year-old man diagnosed with FMD and a 63-year-old man diagnosed with SAM. We conclude that an early diagnosis with imaging modalities and clinical information followed by the appropriate treatment improves the prognosis of these arterial diseases.

    DOI: 10.2169/internalmedicine.3094-19

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  • Pulmonary tumor thrombotic microangiopathy of hepatocellular carcinoma: A case report and review of literature. Reviewed International journal

    Morita S, Kamimura K, Abe H, Watanabe-Mori Y, Oda C, Kobayashi T, Arao Y, Tani Y, Ohashi R, Ajioka Y, Terai S

    World journal of gastroenterology   25 ( 48 )   6949 - 6958   2019.12

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    BACKGROUND: Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare condition in patients with hepatocellular carcinoma (HCC); to date, few cases have been reported. While hepatic dysfunction has been focused on the later stages of HCC, the management of symptoms in PTTM is important for supportive care of the cases. For the better understanding of PTTM in HCC, the information of our recent case and reported cases have been summarized. CASE SUMMARY: A patient with HCC exhibited acute and severe respiratory failure. Radiography and computed tomography of the chest revealed the multiple metastatic tumors and a frosted glass-like shadow with no evidence of infectious pneumonia. We diagnosed his condition as acute respiratory distress syndrome caused by the lung metastases and involvement of the pulmonary vessels by tumor thrombus. Administration of prednisolone to alleviate the diffuse alveolar damages including edematous changes of alveolar wall caused by the tumor cell infiltration and ischemia showed mild improvement in his symptoms and imaging findings. An autopsy showed the typical pattern of PTTM in the lung with multiple metastases. CONCLUSION: PTTM is caused by tumor thrombi in the arteries and thickening of the pulmonary arterial endothelium leading to the symptoms of dyspnea in terminal staged patients. Therefore, supportive management of symptoms is necessary in the cases with PTTM and hence we believe that the information presented here is of great significance for the diagnosis and management of symptoms of PTTM with HCC.

    DOI: 10.3748/wjg.v25.i48.6949

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  • Efficacy of gelatin hydrogels incorporating triamcinolone acetonide for prevention of fibrosis in a mouse model. Reviewed International journal

    Nao Nakajima, Satoru Hashimoto, Hiroki Sato, Kazuya Takahashi, Takuro Nagoya, Kenya Kamimura, Atsunori Tsuchiya, Junji Yokoyama, Yuichi Sato, Hanako Wakatsuki, Masayuki Miyata, Yusuke Akashi, Ryusuke Tanaka, Ken Matsuda, Yasuhiko Tabata, Shuji Terai

    Regenerative therapy   11   41 - 46   2019.12

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    Introduction: Triamcinolone acetonide (TA), a steroid, is often used clinically to prevent dysfunctions associated with fibrosis. The objective of this study was to examine whether TA can be suspended in a gelatin sheet for tissue engineering using a mouse skin wound model. Methods: TA was suspended in biodegradable gelatin and freeze-dried in a sheet form. The sheet was analyzed for homogeneity and controlled release of TA by high-performance liquid chromatography. We made two skin wounds on the dorsal side of mice. Gelatin sheets with TA (TA sheet) and without TA (control sheet) were attached to each skin wound. To determine the efficacy of the prepared TA sheet on the skin wounds, TA-sheet versus TA-injection experiments were conducted. Hematoxylin and eosin staining was performed to assess the grade of epithelialization and alpha smooth muscle actin (α-SMA) immunohistochemical staining was conducted to evaluate myofibroblast infiltration. Results: In the TA-release test in vitro, 7.7 ± 2.3% of TA was released from the sheet by 24 h. After replacing the initial phosphate-buffered saline (PBS) with collagenase PBS, the amount of released TA increased over time. The wound area/original skin wound area after 15 days with the TA sheet was significantly larger than that with the control sheet (26.9 ± 5.5% vs 10.7 ± 2.6%, p = 0.023). The α-SMA positive area/whole area with the TA sheet was significantly lower than that with the control sheet (4.65 ± 0.66% vs 7.24 ± 0.7%, p = 0.023). Furthermore, the α-SMA positive area/whole area with the TA sheet was significantly lower than that with TA injection (5.32 ± 0.45% vs 7.93 ± 0.75%, p = 0.013). Conclusions: We developed a TA sheet and confirmed both the homogeneity of the suspended TA and controlled-release of the TA in the presence of collagenase in vitro. The TA sheet caused less myofibroblast infiltration into the tissue than the control sheet or TA injection did.

    DOI: 10.1016/j.reth.2019.04.001

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  • Rare case of systemic scleroderma showing full-layer histologic features of an ileal lesion. Reviewed International journal

    Hiroki Sato, Terasu Honma, Saki Yamada, Takashi Owaki, Shuji Terai

    Gastrointestinal endoscopy   90 ( 6 )   991 - 993   2019.12

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  • 表在型食道癌患者における禁酒後の体組成変化の検討

    水澤 健, 橋本 哲, 上村 博輝, 高村 昌昭, 寺井 崇二

    アルコールと医学生物学   38   54 - 54   2019.12

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  • 心窩部痛、肝障害を契機に発見されたcholedochoceleの一例

    岩澤 貴宏, 五十嵐 聡, 林 和直, 大脇 崇史, 上村 博輝, 橋本 哲, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   35 ( 2 )   152 - 152   2019.12

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  • A case of pancreatic pseudocysts accompanied by infection, pseudoaneurysm ruptures, and pseudocystocolonic fistulae.

    Kosuke Sato, Kazuya Takahashi, Yukio Aruga, Fusako Yamazaki, Daisuke Kumaki, Masashi Yamakawa, Masaaki Hirano, Kazuhiro Funakoshi, Shuji Terai

    Clinical journal of gastroenterology   12 ( 6 )   615 - 620   2019.12

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    Pancreatic pseudocysts (PPs) can be accompanied by infection, pseudoaneurysm ruptures, and fistulae to other organs, which can be fatal without appropriate treatment. Herein, we present the case of an 82-year-old man with PPs accompanied by infection, pseudoaneurysm rupture, and pseudocystocolonic fistula that were managed via multidisciplinary treatment. Computed tomography (CT) revealed two inflamed PPs, one each in the pancreatic head and tail. He was, therefore, diagnosed with infectious PPs. The pancreatic head PP shrunk on endoscopic nasopancreatic drainage (ENPD), but the pancreatic tail PP did not. Endoscopic ultrasound (EUS)-guided transluminal drainage was performed to treat the pancreatic tail PP; his symptoms improved. However, he vomited blood at 14 day post-drainage. Angiography revealed pseudoaneurysm rupture in a left gastric artery branch. After successful angioembolization, he developed hematochezia 2 days later. We suspected re-bleeding of the pseudoaneurysm. The bleeding stopped spontaneously, but CT and radiography revealed the presence of a pseudocystocolonic fistula. Careful follow-up was performed, and he has not had any symptoms at 9 month post-discharge. We managed PP-related complications via ENPD, EUS-guided transluminal drainage, angioembolization, and careful follow-up. Infection, pseudoaneurysm rupture, and pseudocystocolonic fistula are rare, but can occur simultaneously. Therefore, clinicians should consider these complications when treating patients with PPs.

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  • Gene Therapy for Liver Cancers: Current Status from Basic to Clinics. Reviewed International journal

    Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Shuji Terai

    Cancers   11 ( 12 )   2019.11

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    The liver is a key organ for metabolism, protein synthesis, detoxification, and endocrine function, and among liver diseases, including hepatitis, cirrhosis, malignant tumors, and congenital disease, liver cancer is one of the leading causes of cancer-related deaths worldwide. Conventional therapeutic options such as embolization and chemotherapy are not effective against advanced-stage liver cancer; therefore, continuous efforts focus on the development of novel therapeutic options, including molecular targeted agents and gene therapy. In this review, we will summarize the progress toward the development of gene therapies for liver cancer, with an emphasis on recent clinical trials and preclinical studies.

    DOI: 10.3390/cancers11121865

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  • Methotrexate-related lymphoproliferative disorders in the liver: Case presentation and mini-review. Reviewed International journal

    Takeshi Mizusawa, Kenya Kamimura, Hiroki Sato, Takeshi Suda, Hiroyuki Fukunari, Go Hasegawa, Osamu Shibata, Shinichi Morita, Akira Sakamaki, Junji Yokoyama, Yu Saito, Yoshihisa Hori, Yuduru Maruyama, Fumitoshi Yoshimine, Takahiro Hoshi, Shinichi Morita, Tsutomu Kanefuji, Masaaki Kobayashi, Shuji Terai

    World journal of clinical cases   7 ( 21 )   3553 - 3561   2019.11

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    BACKGROUND: Immunosuppression is effective in treating a number of diseases, but adverse effects such as bone marrow suppression, infection, and oncogenesis are of concern. Methotrexate is a key immunosuppressant used to treat rheumatoid arthritis. Although it is effective for many patients, various side effects have been reported, one of the most serious being methotrexate-related lymphoproliferative disorder. While this may occur in various organs, liver involvement is rare. Information on these liver lesions, including clinical characteristics, course, and imaging studies, has not been summarized to date. CASE SUMMARY: We present a case of 70-year-old woman presented with a 2-wk history of fever and abdominal pain. She had had rheumatoid arthritis for 5 years and was being treated with medication including methotrexate. Contrast-enhanced computed tomography revealed multiple low density tumors in the liver and the histological analyses showed significant proliferation of lymphocytes in masses that were positive on immunohistochemical staining for CD3, CD4, CD8, and CD79a but negative for CD20 and CD56. Staining for Epstein-Barr virus-encoded RNA was negative. And based on these findings, the liver tumors were diagnosed as Methotrexate-related lymphoproliferative disorders. A time-dependent disappearance of the liver tumors after stopping methotrexate supported the diagnoses. CONCLUSION: The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder.

    DOI: 10.12998/wjcc.v7.i21.3553

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  • 肝硬度測定を用いたICG検査の代替の試み

    熊谷 優, 横尾 健, 佐藤 毅昂, 茂木 聡子, 川田 雄三, 薛 徹, 水野 研一, 木村 成宏, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増大会 )   A849 - A849   2019.11

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  • 高齢者表在型食道癌患者における内視鏡的粘膜下層剥離術後の体組成変化の検討

    水澤 健, 橋本 哲, 上村 博輝, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増大会 )   A811 - A811   2019.11

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  • IgG4関連硬化性胆管炎の一例

    中村 涼太, 田中 裕登, 大越 麻里奈, 小関 洋平, 水澤 健, 五十嵐 聡, 林 和直, 佐藤 裕樹, 坂牧 僚, 上村 顕也, 横山 純二, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   65回   81 - 81   2019.11

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  • 複合型免疫不全症を合併する遷延性黄疸が免疫グロブリン療法により改善した一例

    小田 知友美, 土屋 淳紀, 木村 淳史, 冨永 顕太郎, 林 和直, 寺井 崇二

    肝臓   60 ( Suppl.3 )   A1000 - A1000   2019.11

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  • 胃瘻造設によりS状結腸間膜穿孔をきたした一例

    吉田 悠紀, 川田 雄三, 永山 逸夫, 野澤 良祐, 冨永 顕太郎, 薛 徹, 横尾 健, 水野 研一, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   65回・87回   47 - 47   2019.11

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  • 肝癌の局所制御及び集学的治療法としての放射線治療の検討

    上村 顕也, 柴田 理, 寺井 崇二

    肝臓   60 ( Suppl.3 )   A875 - A875   2019.11

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  • 有腹水肝硬変症例に対するtolvaptan投与前後のM2BPGiの経時的変化とその臨床的意義

    高村 昌昭, 坂牧 僚, 寺井 崇二, 上村 博輝, 土屋 淳紀, 薛 徹, 上村 顕也, 横尾 健

    肝臓   60 ( Suppl.3 )   A936 - A936   2019.11

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  • NASHの病態への臓器間ネットワークの関与

    高 昌良, 上村 顕也, 名古屋 拓郎, 井上 良介, 酒井 規裕, 丹羽 祐輔, 坂牧 僚, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増大会 )   A846 - A846   2019.11

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  • Eosinophilic esophagitis after total gastrectomy treated with proton pump inhibitors: a case report. Reviewed

    Takashi Owaki, Hiroki Sato, Ryoko Horigome, Satoru Hashimoto, Terasu Honma, Shuji Terai

    Clinical journal of gastroenterology   12 ( 5 )   420 - 423   2019.10

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    Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder in the esophagus characterized by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation. EoE and Gastro Esophageal Reflux Disease (GERD) are known not to be mutually exclusive and share a complex relationship. Proton pump inhibitors (PPIs), which are generally used in the treatment of GERD, could be used to treat esophageal eosinophilia in suspected EoE. We report a rare case of EoE after total gastrectomy that responded to PPIs. Our case indicates that the onset of EoE does not necessarily require an acid reflux-induced antigen-mediated drive, and the action of PPIs in patients with active EoE is unrelated to gastric acid suppression.

    DOI: 10.1007/s12328-019-00960-4

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  • A rare case of Paneth cell-rich depressed adenoma in the terminal ileum. Reviewed International journal

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Shuji Terai

    Gastrointestinal endoscopy   90 ( 4 )   694 - 695   2019.10

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    DOI: 10.1016/j.gie.2019.05.040

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  • Endoscopic retrieval of a button battery using the tip of a magnetic tube. Reviewed International journal

    Morita S, Yagi K, Terai S

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 6 )   e116-e117   2019.10

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    DOI: 10.1111/den.13498

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  • 肝臓病理の臨床への貢献と次世代への飛躍を目指して 小児NAFLD患者の臨床スコアの動態とSerial Biopsyによる知見

    上村 博輝, 上村 顕也, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A607 - A607   2019.10

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  • 急性膵炎後の諸問題に対する内視鏡の役割 重症急性膵炎後Walled-off necrosisに対するLumen apposing metal stentの有効性

    五十嵐 聡, 林 和直, 寺井 崇二

    Gastroenterological Endoscopy   61 ( Suppl.2 )   2066 - 2066   2019.10

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  • さあ、どうする?治療内視鏡におけるトラブルシューティング(胆膵編) 当科における副乳頭アプローチカニュレーションの工夫

    林 和直, 五十嵐 聡, 寺井 崇二

    Gastroenterological Endoscopy   61 ( Suppl.2 )   2055 - 2055   2019.10

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  • IFN-γ刺激下採取エクソソームは抗炎症マクロファージを誘導し、肝線維化改善に寄与する

    竹内 卓, 土屋 淳紀, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A681 - A681   2019.10

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  • 消化器疾患での間葉系幹細胞を用いた治療法開発

    土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A570 - A570   2019.10

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  • 間葉系幹細胞を"指揮細胞"として用いた肝硬変に対する再生医療の治療戦略

    寺井 崇二, 土屋 淳紀, 竹内 卓

    肝臓   60 ( Suppl.2 )   A561 - A561   2019.10

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  • 非ウイルス性肝炎・肝硬変増加時代の効果的な肝細胞癌リスク患者の拾い上げと専門医による評価

    土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A696 - A696   2019.10

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  • 高齢者におけるFIB-4 indexの特徴

    横尾 健, 薛 徹, 上村 博輝, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A696 - A696   2019.10

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  • 肝癌に対する分子標的治療中のヒスチジンによる肝予備能維持効果と副作用予防

    上村 顕也, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A674 - A674   2019.10

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  • アルコール性肝硬変の予後における、るいそうおよび肥満の影響

    坂牧 僚, 横山 邦彦, 上村 顕也, 高村 昌昭, 寺井 崇二

    肥満研究   25 ( Suppl. )   304 - 304   2019.10

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  • マウス肝線維化進展予防薬の探索及びレトロゾールによる線維化進展予防効果の検証

    酒井 規裕, 上村 顕也, 名古屋 拓郎, 丹羽 佑輔, 高 昌良, 薛 徹, 横尾 健, 坂牧 僚, 榎本 初音, 立木 秀尚, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A680 - A680   2019.10

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  • NASHモデルマウスにおける自律神経系を介したグレリンの関与

    名古屋 拓郎, 上村 顕也, 井上 良介, 酒井 規裕, 後藤 諒, 高 昌良, 丹羽 佑輔, 坂牧 僚, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A682 - A682   2019.10

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  • Wavy mucosal tear in the sigmoid colon. Reviewed International journal

    Kentaro Tominaga, Junji Yokoyama, Kazunao Hayashi, Atsunori Tsuchiya, Shuji Terai

    Clinical case reports   7 ( 9 )   1825 - 1826   2019.9

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    Although linear mucosal tears have been reported, we found a relatively rare case of wavy mucosal tear in collagenous colitis. This may be related to the mutual weak adhesiveness between the epithelium and collagen band. This complication necessitates great care to be taken while performing colonoscopy in patients suspected of collagenous colitis.

    DOI: 10.1002/ccr3.2275

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  • Inhibition of sodium-glucose cotransporter 2 ameliorated renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease. Reviewed International journal

    Nagoya T, Kamimura K, Goto R, Shinagawa-Kobayashi Y, Niwa Y, Kimura A, Sakai N, Ko M, Nishina H, Terai S

    FEBS open bio   9 ( 12 )   2016 - 2024   2019.9

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    The effect of sodium-glucose cotransporter 2 inhibitor (SGLT2I) on nonalcoholic steatohepatitis (NASH) has been reported, but there are few studies on its effect on NASH-related renal injury. In this study, we examined the effect of SGLT2I using a novel medaka fish model of NASH-related kidney disease, which was developed by feeding the d-rR/Tokyo strain a high-fat diet. SGLT2I was administered by dissolving it in water of the feeding tank. SGLT2I ameliorates macrophage accumulation and oxidative stress and maintained mitochondrial function in the kidney. The results demonstrate the effect of SGLT2I on NASH-related renal injury and the usefulness of this novel animal model for research into NASH-related complications.

    DOI: 10.1002/2211-5463.12734

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  • NSTによる消化器内科病変の発見により自宅退院まで改善した症例

    小師 優子, 村山 稔子, 上村 博輝, 小山 諭, 寺井 崇二

    学会誌JSPEN   1 ( Suppl. )   1331 - 1331   2019.9

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  • 非ウイルス性肝硬変時代の門亢症〜ウイルス性との共通点・相違点を中心に〜 原発性胆汁性胆管炎における食道・胃静脈瘤の検討

    薛 徹, 横山 純二, 高綱 将史, 荒生 祥尚, 上村 輝博, 坂牧 僚, 横尾 健, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    日本門脈圧亢進症学会雑誌   25 ( 3 )   110 - 110   2019.9

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  • 門亢症に伴う慢性肝不全の臓器関連〜脳・腎・腸〜 NASHの病態進行との自律神経を介した臓器間ネットワークの関与

    高 昌良, 上村 顕也, 名古屋 拓郎, 大脇 崇史, 井上 良介, 酒井 規裕, 丹羽 祐輔, 坂牧 僚, 横尾 健, 寺井 崇二

    日本門脈圧亢進症学会雑誌   25 ( 3 )   77 - 77   2019.9

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  • Change in body composition in patients with achalasia before and after peroral endoscopic myotomy. Reviewed International journal

    Takeshi Mizusawa, Hiroki Sato, Kenya Kamimura, Satoru Hashimoto, Ken-Ichi Mizuno, Hiroteru Kamimura, Satoshi Ikarashi, Kazunao Hayashi, Masaaki Takamura, Junji Yokoyama, Shuji Terai

    Journal of gastroenterology and hepatology   35 ( 4 )   601 - 608   2019.8

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    BACKGROUND AND AIM: Patients with achalasia experience weight loss because of dysphagia caused by impaired relaxation of the lower esophageal sphincter. This study aimed to use dual bioelectrical impedance analysis (BIA) to determine the change in bodyweight and body composition in patients with achalasia before and after peroral endoscopic myotomy (POEM). METHODS: Patients with achalasia who underwent POEM from 2013 to 2018 (n = 72) were retrospectively analyzed for change in bodyweight before and after 3 months. Additionally, change in body composition was prospectively investigated in the final 10 of 72 patients using non-radiation dual BIA. RESULTS: Twenty patients (27.8%) were underweight (body mass index < 18.5) before undergoing POEM. No clinical parameters were identified to be associated with the underweight condition before POEM and be predictive of an increase in bodyweight after POEM. Low visceral fat volume observed on dual BIA correlated closely with the result obtained using computed tomography (Pearson correlation coefficient: r = 0.850, P < 0.01). Patients with achalasia had a statistically significant increase in visceral (P < 0.01) and subcutaneous fat volumes (P < 0.01) after POEM. Skeletal muscle mass index slightly increased (P = 0.02), although the value after POEM was still low. No blood biomarkers were indicators for low bodyweight or low visceral fat volume. CONCLUSIONS: Dual BIA is an effective non-invasive tool to evaluate the change in body composition of underweight patients with achalasia. Skeletal muscle volume was not enough after POEM, although a rapid increase in the intra-abdominal fat volume was observed. Additional studies are warranted to understand the pathological implications.

    DOI: 10.1111/jgh.14847

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  • Methotrexate-Associated Lymphoproliferative Disorder: A Rare Case of Large Liver Tumors. International journal

    Saori Watanabe, Kazuya Takahashi, Kazuhiro Funakoshi, Shuji Terai

    Hepatology (Baltimore, Md.)   70 ( 2 )   748 - 750   2019.8

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    DOI: 10.1002/hep.30606

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  • Epidemiological analysis of achalasia in Japan using a large-scale claims database Reviewed

    Sato, H., Yokomichi, H., Takahashi, K., Tominaga, K., Mizusawa, T., Kimura, N., Kawata, Y., Terai, S.

    Journal of Gastroenterology   54 ( 7 )   621 - 627   2019.7

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    DOI: 10.1007/s00535-018-01544-8

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  • Case of early-stage gastric cancer identified in the gastric mucosa with lanthanum phosphate deposition. Reviewed

    Takatsuna M, Takeuchi M, Usuda H, Terai S

    Endoscopy international open   7 ( 7 )   E893 - E895   2019.7

  • Colorectal neuroendocrine carcinoma: A case report and review of the literature. Reviewed International journal

    Yoshida T, Kamimura K, Hosaka K, Doumori K, Oka H, Sato A, Fukuhara Y, Watanabe S, Sato T, Yoshikawa A, Tomidokoro T, Terai S

    World journal of clinical cases   7 ( 14 )   1865 - 1875   2019.7

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    BACKGROUND: Colorectal neuroendocrine carcinoma (NEC) is a rare tumor that demonstrates aggressive growth pattern with ingrowth into the tract, metastasis to the other organs, and invasion to the surrounding organs; these clinical characteristics result in poor prognosis. Surgical resection appears as an effective approach; however, because it is difficult to accurately diagnose NEC during the early stage and owing to its aggressive growth pattern, development of a reliable standard chemotherapy regimen and management strategies are essential. CASE SUMMARY: Here, we report the case of patient with NEC showing an aggressive growth pattern that resulted in the rupture of the tumor to the outside the colon after stenting of the internal colonic stenosis. In addition, the tumor invaded into the duodenum, thereby causing duodenal stenosis that required an additional stent in the duodenum. This aggressive growth pattern is one of the main features of the NEC that is different from adenocarcinoma. To clarify the clinical characteristics, we reviewed 60 recently reported cases, including data on tumor location, size, treatment, and prognosis. CONCLUSION: We consider that the information presented here is of great significance for the diagnosis, treatment, and management of symptoms of the patients with NEC.

    DOI: 10.12998/wjcc.v7.i14.1865

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  • Delayed pancreatic ductal leakage after EUS-FNA for autoimmune pancreatitis. Reviewed

    Ikarashi S, Tsuchiya A, Hayashi K, Terai S

    Endoscopic ultrasound   8 ( 4 )   277 - 278   2019.7

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  • 肝癌薬剤耐性におけるエクソソームの有用性および課題

    松田 康伸, 寺井 崇二

    BIO Clinica   34 ( 7 )   737 - 740   2019.7

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  • A case report of psychiatric symptoms following direct-acting antiviral and ribavirin combination therapy for chronic hepatitis C in a patient with innate anxiety. Reviewed International journal

    Akira Sakamaki, Kenya Kamimura, Naoki Fukui, Haruka Watanabe, Norihiro Sakai, Kentaro Tominaga, Kenichi Mizuno, Masaaki Takamura, Hirokazu Kawai, Takuro Sugai, Satoshi Yamagiwa, Toshiyuki Someya, Shuji Terai

    BMC gastroenterology   19 ( 1 )   85 - 85   2019.6

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    BACKGROUND: Direct-acting antivirals (DAAs) result in a highly sustained virological response rate and better patient tolerance. However, this therapeutic approach may, on rare occasions, give rise to psychiatric symptoms. We describe a case requiring discontinuation of DAA and ribavirin combination therapy due to psychiatric symptoms in a patient with congenital anxious personality traits. The information summarized here will be helpful to physicians treating chronic hepatitis C virus (HCV) infection in patients with underlying psychiatric problems. CASE PRESENTATION: A 57-year-old Japanese woman diagnosed with chronic HCV infection was prescribed DAA and ribavirin combination therapy. She had a history of mild innate anxiety and development of psychiatric symptoms due to interferon (IFN) therapy 8 years prior, which subsided with discontinuation of the therapy. Similar psychiatric symptoms such as enervation, palpitations, an episode of hyperventilation, and consciousness disturbances with myotonia were observed after the administration of the antiviral agents. No abnormal findings related to her symptoms were observed on laboratory or imaging results. Psychiatrists diagnosed the patient as having a somatization disorder induced by the antiviral agents on the basis of innate anxiety. After the discontinuation of therapy, her symptoms gradually improved. CONCLUSIONS: Although DAAs were not causative factors for psychiatric symptoms in phase 3 studies, a post-marketing study reported psychiatric symptoms such as depression in patients with underlying psychiatric problems. Our case suggests psychiatric symptoms might worsen after DAA and ribavirin administration in patients with underlying psychiatric disorders, and therefore, close monitoring is necessary for these patients, especially if they have a history of psychiatric symptoms after IFN.

    DOI: 10.1186/s12876-019-1013-1

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  • Evaluating the effect of injecting triamcinolone acetonide in two sessions for preventing esophageal stricture after endoscopic submucosal dissection. Reviewed International journal

    Satoru Hashimoto, Ken-Ichi Mizuno, Kazuya Takahashi, Hiroki Sato, Junji Yokoyama, Manabu Takeuchi, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    Endoscopy international open   7 ( 6 )   E764-E770 - E770   2019.6

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    Background and study aims  Several previous reports indicate that endoscopic injection of triamcinolone acetonide (TA) after widespread endoscopic submucosal dissection (ESD) is effective for preventing esophageal stricture. We investigated the efficacy of injecting TA in two sessions for preventing stricture formation post-ESD. Patients and methods  Sixty-six consecutive patients with widespread mucosal defects that affected more than three-fourths of the circumference of the esophagus were included. The study group (n = 40) received TA injections over two sessions: immediately after and 14 days after ESD. The control group (n = 26) did not receive a TA injection. This study was performed retrospectively against historical controls. The primary endpoint of this study was frequency of stricture after TA injection. The secondary endpoint was number of required endoscopic balloon dilations (EBDs) after TA injection. Results  The post-ESD stricture rate among patients who had subcircumferential mucosal defects was 45.7 % in the study group (16/35 patients), which was significantly lower than the rate of 73.9 % in the control group (17/23 patients; P  = 0.031). The number of EBD procedures required was significantly lower in the study group (median 0, range 0 - 7) than in the control group (median 4, range 0 - 20; P  < 0.001). There was no significant difference between the study and control groups among the patients who had full circumferential mucosal defects. Conclusion  This study showed that performing two sessions of TA injection is an effective and safe treatment for prevention of esophageal stricture following subcircumferential ESD.

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  • 医学・医療におけるシミュレータの進歩と普及(Vol.23) 消化器領域超音波のシミュレータ 腹部超音波/超音波内視鏡

    林 和直, 五十嵐 聡, 寺井 崇二

    医学のあゆみ   269 ( 12 )   945 - 948   2019.6

  • ダブルバルーン内視鏡で診断に至った消化管重複症の成人例

    丹羽 佑輔, 上村 顕也, 小林 隆昌, 高橋 一也, 冨永 顕太郎, 河久 順志, 阿部 聡司, 川合 弘一, 横山 純二, 杉野 英明, 梅津 哉, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   35 ( 1 )   44 - 44   2019.6

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  • FDG-PETが重粒子線治療の効果判定に有用であった、若年者切除不能肝内胆管癌の1例

    渡邉 緑, 柴田 理, 上村 顕也, 安住 里映, 渋谷 圭, 大野 達也, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   64回   34 - 34   2019.6

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  • Rational arrangement of measuring shear wave speed in the liver. Reviewed International journal

    Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Itsuo Nagayama, Takahiro Hoshi, Satoshi Abe, Shinichi Morita, Hiroteru Kamimura, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Kazuyoshi Yagi, Shuji Terai

    World journal of gastroenterology   25 ( 20 )   2503 - 2513   2019.5

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    BACKGROUND: Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM: To provide procedural standardization of shear wave speed measurement. METHODS: Point shear wave elastography (pSWE) was measured in 781 patients, and two-dimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS: The CVR showed a significantly broader distribution in the left lobe (P < 0.0001), and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION: These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes.

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  • Utility of measuring paraesophageal varices using computed tomography to select endoscopic treatment for patients with esophageal varices Reviewed

    Kimura, N., Yokoyama, J., Terai, S.

    Digestive Endoscopy   31 ( 3 )   335 - 335   2019.5

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    DOI: 10.1111/den.13383

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  • A rare duodenal carcinosarcoma: A case report and literature review Reviewed

    Arao, Y., Kamimura, K., Ikemi, M., Takaki, M., Takahashi, S., Seino, S., Abe, H., Kohisa, J., Kato, T., Ajioka, Y., Terai, S.

    Internal Medicine   58 ( 9 )   1273 - 1278   2019.5

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    DOI: 10.2169/internalmedicine.2094-18

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  • Efficacy and safety of ribavirin therapy for chronic hepatitis E after kidney transplantation. Reviewed International journal

    Yoshida T, Takamura M, Goto R, Takeuchi S, Tsuchiya A, Kamimura K, Tasaki M, Nakagawa Y, Saito K, Tomita Y, Terai S

    Hepatology research : the official journal of the Japan Society of Hepatology   49 ( 10 )   1244 - 1248   2019.5

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    Hepatitis E virus (HEV) infection has been recognized as an acute condition. However, recent reports have shown that immunocompromised patients, such as those receiving solid-organ transplantation, can develop chronic hepatitis with HEV infection. We report two cases of chronic hepatitis E after kidney transplantation (KT) who were successfully treated with ribavirin monotherapy. Several years after KT, both patients had sustained elevations in the levels of liver enzymes for a period of more than 6 months. Both patients had HEV infection, genotype 3a. Histological studies showed infiltration of inflammatory cells without fibrosis. Treatment included ribavirin monotherapy at a dosage of 600 mg daily for 3 months. One month after therapy initiation, HEV-RNA turned to negative, and remained negative at 24 weeks after ribavirin therapy without severe complications. Although the treatment of chronic hepatitis E is not fully established, ribavirin therapy can be a safe and effective treatment for chronic hepatitis E.

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  • Multiple Endocrine Neoplasia Type 1-Related Acute Pancreatitis. Reviewed

    Takahashi S, Kamimura K, Abe H, Watanabe Y, Hayashi K, Mizuno K, Yamamoto T, Takeuchi M, Natsui M, Terai S

    Pancreas   48 ( 5 )   e35 - e38   2019.5

  • Endoscopic ultrasound-guided hepaticogastrostomy using a novel covered metallic stent with a fine-diameter delivery system Reviewed

    Morita, S., Yagi, K., Terai, S.

    Digestive Endoscopy   31 ( 3 )   e60 - e61   2019.5

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    DOI: 10.1111/den.13347

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  • Submucosal painting for gastroduodenal stent placement. Reviewed International journal

    Morita S, Suda T, Terai S

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 3 )   e64 - e65   2019.5

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    DOI: 10.1111/den.13349

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  • 膵癌術前胆道ドレナージにおける大口径プラスチックステントの役割

    五十嵐 聡, 林 和直, 寺井 崇二, 水澤 健, 川田 雄三, 冨永 顕太郎, 佐藤 裕樹, 水野 研一, 橋本 哲, 横山 純二, 高村 昌昭

    Gastroenterological Endoscopy   61 ( Suppl.1 )   981 - 981   2019.5

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  • 慢性膵炎による膵管狭窄に対するステント治療の現状と課題

    林 和直, 五十嵐 聡, 寺井 崇二, 水澤 健, 冨永 顕太郎, 佐藤 裕樹, 水野 研一, 橋本 哲, 横山 純二

    Gastroenterological Endoscopy   61 ( Suppl.1 )   1000 - 1000   2019.5

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  • 当院における小腸カルチノイド7例の臨床的検討

    冨永 顕太郎, 川田 雄三, 本田 穣, 上村 顕也, 横山 純二, 寺井 崇二, 田島 陽介, 中野 雅人, 島田 能史, 亀山 仁史, 若井 俊文, アネコフ・アレクセイ, 味岡 洋一, 阿部 達也, 梅津 哉, 岩渕 三哉

    日本大腸肛門病学会雑誌   72 ( 5 )   348 - 348   2019.5

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  • A Rare Case Involving the Inability to Belch. Reviewed

    Hiroki Sato, Shunzo Ikarashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   58 ( 7 )   929 - 931   2019.4

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    A 17-year-old girl was referred to our hospital with an inability to belch, while experiencing chest gurgling noises, and severe abdominal bloating. She reported having these symptoms all her life. A timed barium esophagogram revealed a moderate amount of bubbles in the esophagus and gastric fundus, which significantly increased after the examination. High resolution manometry revealed that the basal upper esophageal sphincter pressure increased with a rise in the cervical esophageal pressure. A pathological inability to belch is rare; at present, no specific name exists to describe the disorder. Further research is needed in this unexplored field.

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  • Duodenal lymphangiectasia distinguished from follicular lymphoma by narrow-band imaging magnification endoscopy Reviewed

    Tominaga, K., Tsuchiya, A., Mizuno, K.-I., Terai, S.

    Gastrointestinal Endoscopy   90 ( 3 )   2019.4

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    DOI: 10.1016/j.gie.2019.04.220

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  • Overlap in disease concept of functional esophageal disorders and minor esophageal motility disorders. Reviewed

    Sato H, Takahashi K, Mizuno KI, Hashimoto S, Kawata Y, Mizusawa T, Tominaga K, Yokoyama J, Terai S

    Journal of gastroenterology and hepatology   34 ( 11 )   1940 - 1945   2019.4

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    DOI: 10.1111/jgh.14691

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  • Esophageal Stenosis by Prostate Cancer Metastasis Reviewed

    Kamimura, K., Shinagawa-Kobayashi, Y., Mizuno, K., Terai, S.

    American Journal of Gastroenterology   114 ( 4 )   685 - 687   2019.4

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    DOI: 10.14309/ajg.0000000000000185

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  • Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients. Reviewed International journal

    Kamimura K, Sakamaki A, Kamimura H, Setsu T, Yokoo T, Takamura M, Terai S

    World journal of gastroenterology   25 ( 15 )   1817 - 1827   2019.4

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    The aging of the organ function causes sensitivity to the disease progression and need careful consideration for the medical treatment. With the increase of aging population, the opportunity to provide medical treatment for people in very old age is rapidly increasing therefore, the understanding of the various physiological changes of cellular function, size and function of organs are essential for the decision of therapeutic options. Among the various chronic conditions seen in elderly people, we have focused on liver cirrhosis, since despite specific therapeutic options for many of liver diseases including direct acting antivirals for hepatitis C virus, nucleoside analogs for hepatitis B, and corticosteroids for autoimmune hepatitis, there is currently no standard therapy to treat liver cirrhosis, which is the final stage of these liver diseases. Therefore, management of the various symptoms of liver cirrhosis is essential, and aging-related parameters must be considered in the decision making for therapeutic strategies and dosage of the available medicine. In this mini-review, we have summarized the therapeutic options to manage various symptoms of liver cirrhosis, carefully considering the physiological changes of various organs associated with aging.

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  • Inhibition of sodium glucose cotransporter 2 (SGLT2) delays liver fibrosis in a medaka model of nonalcoholic steatohepatitis (NASH). Reviewed International journal

    Goto R, Kamimura K, Shinagawa-Kobayashi Y, Sakai N, Nagoya T, Niwa Y, Ko M, Ogawa K, Inoue R, Yokoo T, Sakamaki A, Kamimura H, Abe S, Nishina H, Terai S

    FEBS open bio   9 ( 4 )   643 - 652   2019.4

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    The rise in the incidence of nonalcoholic steatohepatitis (NASH) has necessitated the development of an effective prevention methodology. An antidiabetic drug, belonging to the group of sodium glucose cotransporter 2 (SGLT2) inhibitors, has been tested for its therapeutic effect on NASH; however, no studies to date have demonstrated the preventive effect of an SGLT2 inhibitor on the histological progression of steatosis and fibrosis in a sequential manner in animal models. In the present study, we examined the effect of the SGLT2 inhibitor, tofogliflozin (Tofo), on NASH liver tissue using medaka as an animal model, maintaining a feeding amount and drug concentration in all animal bodies. We generated a medaka NASH model by feeding d-rR/Tokyo medaka a high-fat diet and administered Tofo by dissolving the drug directly in the water of the feeding tank. Thereafter, the effects of Tofo on body weight (BW), liver weight, hepatotoxicity, fatty infiltration, and fibrotic changes in the liver were examined. We report here that SGLT2 is expressed in medaka fish and that Tofo inhibits the accumulation of fatty tissue and delays the progression of liver fibrosis in the medaka NASH model by inhibiting increases in blood sugar, serum lipids, and transaminase, irrespective of changes in BW. These results suggest that Tofo is effective for treating NASH and that the medaka model may be useful for developing new therapeutic drugs for this disease.

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  • Usefulness of CCR7<sup>-</sup> PD-1<sup>+</sup> follicular helper T cell subset frequencies in the diagnosis of autoimmune hepatitis. Reviewed

    Kimura N, Yamagiwa S, Sugano T, Horigome R, Setsu T, Tominaga K, Kamimura H, Takamura M, Terai S

    Hepatology research : the official journal of the Japan Society of Hepatology   49 ( 9 )   1026 - 1033   2019.4

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  • Management of endoscopic submucosal dissection for ulcerative colitis‐associated neoplasia: Tips and pitfalls

    Ken‐ichi Mizuno, Junji Yokoyama, Shuji Terai

    Digestive Endoscopy   31 ( S1 )   44 - 45   2019.4

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    DOI: 10.1111/den.13324

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  • 当院における高齢発症原発性胆汁性胆管炎患者の予後予測マーカーについて

    高村 昌昭, 木村 成宏, 薛 徹, 上村 博輝, 坂牧 僚, 横尾 健, 土屋 淳紀, 上村 顕也, 松田 康伸, 寺井 崇二

    肝臓   60 ( Suppl.1 )   A407 - A407   2019.4

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  • 急性肝不全:救命率の向上を目指した取り組み 本県における急性肝不全診療ネットワーク構築の取り組み

    薛 徹, 高村 昌昭, 寺井 崇二

    肝臓   60 ( Suppl.1 )   A211 - A211   2019.4

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  • メダカを用いた食品・医薬品の機能性評価基盤の構築 メダカモデルを用いた薬物スクリーニングと医学研究応用

    寺井 崇二, 上村 顕也

    日本栄養・食糧学会大会講演要旨集   73回   174 - 174   2019.4

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  • 肝癌診療ガイドライン2017を再検証する 肝癌に対する放射線治療の検討

    上村 顕也, 柴田 理, 寺井 崇二

    肝臓   60 ( Suppl.1 )   A132 - A132   2019.4

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  • NASH/NAFLDの病態解明に向けた基礎的検討 NASH/NAFLDの病態における自律神経を介した消化管ホルモンの関与

    上村 顕也, 名古屋 拓郎, 寺井 崇二

    肝臓   60 ( Suppl.1 )   A146 - A146   2019.4

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  • 肝癌に対する分子標的薬の有害事象の発症予測

    上村 顕也, 寺井 崇二

    肝臓   60 ( Suppl.1 )   A487 - A487   2019.4

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  • 免疫チェックポイント阻害薬による免疫関連有害事象と考えられる肝障害を呈した2例

    坂牧 僚, 上村 顕也, 寺井 崇二

    肝臓   60 ( Suppl.1 )   A488 - A488   2019.4

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  • Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment. Reviewed International journal

    Hiroki Sato, Manabu Takeuchi, Satoru Hashimoto, Ken-Ichi Mizuno, Koichi Furukawa, Akito Sato, Junji Yokoyama, Shuji Terai

    World journal of gastroenterology   25 ( 12 )   1457 - 1464   2019.3

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    Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant, minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy (POEM). However, the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience.

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  • M2-polarized macrophages relate the clearance of gastric lanthanum deposition Reviewed

    Nakamura, T., Tsuchiya, A., Kobayashi, M., Naito, M., Terai, S.

    Clinical Case Reports   7 ( 3 )   570 - 572   2019.3

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  • Diverse perspectives to address for the future treatment of heterogeneous hepatocellular carcinoma. Reviewed International journal

    Tsuchiya A, Ogawa M, Watanabe T, Takeuchi S, Kojima Y, Watanabe Y, Kimura N, Hayashi K, Yokoyama J, Terai S

    Heliyon   5 ( 3 )   e01325   2019.3

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    Hepatocellular carcinomas (HCCs), which often arise from chronic liver damage, have poor conditional 5-year survival and are recognized as heterogeneous tumors. Considering the heterogeneity of HCCs, diverse perspectives need to be addressed for treating such tumors, besides the findings of conventional imaging modalities and tumor markers. Data from the latest technologies, such as liquid biopsy, and the detection of the presence of cancer cells with stem/progenitor cell markers, gene mutations and diverse pathways, crosstalk with immune cells and cancer-associated fibroblasts, and mechanisms of epithelial-mesenchymal transition provide diverse lines of information. Integration of these data with clinical data might be necessary to develop effective therapies for precision medicine. Here, we review several aspects of dealing with the complexity of heterogeneous HCCs.

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  • 当院における切除不能局所進行膵癌の治療の現況

    林 和直, 五十嵐 聡, 水澤 健, 川田 雄三, 冨永 顕太郎, 佐藤 裕樹, 水野 研一, 橋本 哲, 横山 純二, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A468 - A468   2019.3

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  • 術後再建腸管例におけるEUS-FNAの現状と工夫

    五十嵐 聡, 林 和直, 水澤 健, 川田 雄三, 冨永 顕太郎, 佐藤 裕樹, 水野 研一, 橋本 哲, 横山 純二, 高村 昌昭, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A299 - A299   2019.3

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  • 当院における肝癌に対する放射線治療の検討

    柴田 理, 上村 顕也, 木村 成宏, 薛 徹, 横尾 健, 坂牧 僚, 上村 博輝, 土屋 淳紀, 高村 昌昭, 丸山 克也, 太田 篤, 海津 元樹, 青山 英史, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A456 - A456   2019.3

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  • 難治性潰瘍性大腸炎の治療戦略における外科と内科のコラボレーション 難治性潰瘍性大腸炎に対する治療と今後の課題

    横山 純二, 冨永 顕太郎, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A53 - A53   2019.3

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  • 消化器領域における腸内細菌研究と臨床応用 空置腸炎に対宇る自家糞便移植の有用性と腸内細菌叢への影響の解明

    冨永 顕太郎, 横山 純二, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A161 - A161   2019.3

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  • メタボリックシンドロームとしての脂肪肝 SGLT2阻害薬によるNASH進展抑制効果の検証 メダカNASHモデルを用いて

    上村 顕也, 後藤 諒, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A142 - A142   2019.3

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  • Radial incision and cutting for refractory benign esophageal stricture. International journal

    Takeshi Mizusawa, Masaaki Kobayashi, Shuji Terai

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 2 )   e46-e47   2019.3

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    DOI: 10.1111/den.13329

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  • 肝線維化研究の展開と臨床応用 マウス肝線維化進展予防薬の探索及びレトロゾールによる線維化進展予防効果の検証

    酒井 規裕, 上村 顕也, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A214 - A214   2019.3

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  • 高齢肝癌症例におけるソラフェニブの効果と有用性

    横尾 健, 森田 真一, 木村 成宏, 薛 徹, 坂牧 僚, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A413 - A413   2019.3

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  • Clinical and pathological profile of eosinophilic gastroenteritis. Reviewed International journal

    Hiroki Sato, Terasu Honma, Takashi Owaki, Kentaro Tominaga, Junji Yokoyama, Shuji Terai

    European journal of gastroenterology & hepatology   31 ( 2 )   157 - 162   2019.2

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    BACKGROUND: Eosinophilic gastroenteritis (EoGE) can be diagnosed on the basis of histologic criteria; however, the pathology is considered to be heterogeneous. There is no consensus on the management of this enigmatic disorder with an unknown etiology. PATIENTS AND METHODS: Data for patients diagnosed with EoGE and followed up over a 1-year period were analyzed. Their symptoms, patterns of flares, and type of treatment were documented. The shift in peripheral blood eosinophil levels was also examined. RESULTS: A total of 10 (mean age, 44 years; range: 31-70 years; women, 5) patients were diagnosed with EoGE. The most frequent presenting symptom was abdominal pain, and eight patients were classified with mucosal type of EoGE. Chronic disease or multiple flares were observed in seven out of 10 (70.0%) patients, and all of them had a history of allergy. Four were corticosteroid dependent (three relapsed during corticosteroid tapering and one following corticosteroid withdrawal). One of them received anti-IL5 monoclonal antibody that enabled corticosteroid dose tapering. In four patients with highly elevated initial eosinophil levels at diagnosis, the peripheral eosinophil level correlated with the amelioration and deterioration of their symptoms. The remaining three patients had a single flare without relapse. Two had no history of allergy. CONCLUSION: EoGE is a unique disorder with a variable clinical course. Although further studies are required to confirm our observations, the presence of other allergic disorders is associated with chronicity or multiple flares. Peripheral eosinophil level may be an effective biomarker for recurrence in patients with severe systemic disorders at diagnosis.

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  • Co-existent ulcerative colitis and Guillain-Barré syndrome: a case report and literature review. Reviewed

    Tominaga K, Tsuchiya A, Sato H, Kimura A, Oda C, Hosaka K, Kawata Y, Kimura N, Hayashi K, Yokoyama J, Terai S

    Clinical journal of gastroenterology   12 ( 3 )   243 - 246   2019.2

  • A cut-off value of shear wave speed to distinguish nonalcoholic steatohepatitis candidates Reviewed

    Suda, T., Kanefuji, T., Abe, A., Nagayama, I., Hoshi, T., Morita, S., Yagi, K., Hatakeyama, S., Hayatsu, M., Hasegawa, N., Terai, S.

    Medicine (United States)   98 ( 2 )   e13958   2019.1

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    DOI: 10.1097/MD.0000000000013958

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  • Early injection of human adipose tissue-derived mesenchymal stem cell after inflammation ameliorates dextran sulfate sodium-induced colitis in mice through the induction of M2 macrophages and regulatory T cells. Reviewed

    Kawata Y, Tsuchiya A, Seino S, Watanabe Y, Kojima Y, Ikarashi S, Tominaga K, Yokoyama J, Yamagiwa S, Terai S

    Cell and tissue research   376 ( 2 )   257 - 271   2019.1

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    DOI: 10.1007/s00441-018-02981-w

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  • EpCAM- and/or NCAM-Expressing Hepatocellular Carcinoma in Which Behavior of Hepatic Progenitor Cell Marker-Positive Cells Are Followed. Reviewed

    Tsuchiya A, Suda T, Oda C, Kimura A, Hosaka K, Kimura N, Tominaga K, Hayashi K, Takamura M, Terai S

    Case reports in gastroenterology   13 ( 1 )   118 - 124   2019.1

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    DOI: 10.1159/000498913

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  • Re-examination using newly proposed diagnostic criteria of acute-on-chronic liver failure in Japan Reviewed

    Nojiri, S., Tsuchiya, A., Terai, S.

    Hepatology Research   49 ( 1 )   2019

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    DOI: 10.1111/hepr.13238

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  • Effective prevention of sorafenib-related vascular damage induced adverse events and maintenance of hepatic function by dried bonito broth and histidine. Reviewed International journal

    Sakai N, Kamimura K, Shinagawa-Kobayashi Y, Nagoya T, Niwa Y, Ko M, Setsu T, Sakamaki A, Yokoo T, Abe S, Kamimura H, Sugitani S, Yanagi M, Terai S

    Cancer management and research   11   4437 - 4448   2019

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    Background: Sorafenib (SOR) is an anti-angiogenic chemotherapeutic that prolongs the survival rates of patients with hepatocellular carcinoma. However, SOR also damages normal vasculature and causes associated adverse events, including hand-foot syndrome and hypertension (HT). We previously reported in an animal study that vascular damage resulted in the narrowing of the normal vascular dimension area in medaka fish (Oryzias), and histidine (HIS), a major amino acid contained in dried bonito broth (DBB), prevented these changes. Therefore, in the study, we analyzed the effects of DBB and HIS on SOR-related vascular damages and associated adverse events in patients. Materials and methods: Three-dimensional (3D) vascular images of abdominal regions reconstituted from computed tomography were assessed to compare vascular diameter prior to and following SOR administration in groups receiving SOR monotherapy, DBB+SOR, and HIS+SOR. The clinical courses of hand-foot syndrome and HT and the toxicities of SOR in biochemical assays were monitored and compared between the groups. Correlations between hepatic function and SOR-related changes in the portal venous area dimension were also assessed. Results: SOR-related vascular damage revealed narrowing of the normal abdominal vasculature in the human body, which was monitored using 3D images. The damage was ameliorated by DBB and HIS, however, HIS had a more marked effect, particularly on the renal arteries and portal vein (PV). Maintenance of blood flow contributed to the maintenance of total cholesterol, prothrombin time, albumin (ALB), and renal functions. Changes in the 3D vascular area dimension of the PV and level of serum ALB were significantly correlated. The occurrences of the clinical symptoms of hand-foot syndrome and HT were lower in the DBB- and HIS-treated groups. Conclusion: Our results clearly demonstrate that DBB and HIS prevented SOR-related abdominal vascular damage and effectively maintained hepatic function, and prevented clinical symptoms and toxicity. Trial registration: This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000025937 and UMIN000026898).

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  • A First Ileus Event in an Elderly Man With Malrotation Reviewed

    Tominaga, K., Tsuchiya, A., Terai, S.

    Gastroenterology   156 ( 3 )   35026 - 1   2019

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    DOI: 10.1053/j.gastro.2018.09.035

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  • Dynamic changes in basal lamina fenestrations in rat intestinal villous epithelium under high-fat diet condition Reviewed

    Morita Keisuke, Azumi Rie, Sato Masatoshi, Mizutani Yusuke, Hayatsu Manabu, Terai Shuji, Ushiki Tatsuo

    BIOMEDICAL RESEARCH-TOKYO   40 ( 2 )   57 - 66   2019

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    DOI: 10.2220/biomedres.40.57

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  • Different distribution of mucosal-associated invariant T cells within the human cecum and colon. Reviewed

    Hama I, Tominaga K, Yamagiwa S, Setsu T, Kimura N, Kamimura H, Wakai T, Terai S

    Central-European journal of immunology   44 ( 1 )   75 - 83   2019

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    DOI: 10.5114/ceji.2019.84020

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  • Correction to: The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection (Gastric Cancer, (2019), 22, 3, (567-575), 10.1007/s10120-018-0878-y)

    Azumi, M., Takeuchi, M., Koseki, Y., Kumagai, M., Kobayashi, Y., Takatsuna, M., Yoshioka, A., Yoshikawa, S., Miura, T., Terai, S.

    Gastric Cancer   22 ( 3 )   576 - 576   2019

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    DOI: 10.1007/s10120-018-0886-y

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  • Microbiome in Liver Cirrhosis

    Sakamaki, A., Takamura, M., Terai, S.

    The Evolving Landscape of Liver Cirrhosis Management   2019

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    DOI: 10.1007/978-981-13-7979-6_7

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  • A case of early<sup>-</sup>stage gastric mixed adenoneuroendocrine carcinoma (MANEC),早期胃 mixed adenoneuroendocrine carcinoma(MANEC)の 例

    Koseki, Y., Takatsuna, M., Kumagai, M., Kobayashi, Y., Azumi, M., Yoshioka, A., Yoshikawa, S., Usuda, H., Takeuchi, M., Terai, S.

    Gastroenterological Endoscopy   61 ( 12 )   2019

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    DOI: 10.11280/gee.61.2604

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  • The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection

    Azumi, M., Takeuchi, M., Koseki, Y., Kumagai, M., Kobayashi, Y., Takatsuna, M., Yoshioka, A., Yoshikawa, S., Miura, T., Terai, S.

    Gastric Cancer   22 ( 3 )   2019

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    DOI: 10.1007/s10120-018-0878-y

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  • Gastrointestinal: Endoscopic diverticulectomy for the treatment of Zenker's diverticulum with a unique “tip”: A first case report in Japan

    Sato, H., Takeuchi, M., Terai, S.

    Journal of Gastroenterology and Hepatology (Australia)   34 ( 8 )   1272 - 1272   2019

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    DOI: 10.1111/jgh.14599

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  • Long-Term Culture of Mouse Fetal Hepatic Stem/Progenitor Cells

    Tsuchiya, A., Terai, S.

    Methods in molecular biology (Clifton, N.J.)   1905   2019

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    DOI: 10.1007/978-1-4939-8961-4_1

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  • Mesenchymal stem cell therapies for liver cirrhosis: MSCs as "conducting cells" for improvement of liver fibrosis and regeneration

    Tsuchiya, A., Takeuchi, S., Watanabe, T., Yoshida, T., Nojiri, S., Ogawa, M., Terai, S.

    Inflammation and Regeneration   39 ( 1 )   2019

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    DOI: 10.1186/s41232-019-0107-z

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  • Hepatobiliary and Pancreatic: AL amyloidosis presented as a hematoma in the hepatoduodenal ligament

    Kobayashi, T., Yoshikawa, S., Takeuchi, M., Terai, S.

    Journal of Gastroenterology and Hepatology (Australia)   34 ( 11 )   1897 - 1897   2019

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    DOI: 10.1111/jgh.14744

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  • 肝胆膵疾患に対する低侵襲治療の工夫 当院におけるWalled-off necrosis(WON)に対する内視鏡治療成績の検討

    林 和直, 五十嵐 聡, 河久 順志, 横山 純二, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   34 ( 2 )   189 - 189   2018.12

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  • Gastrointestinal: A case of hypereosinophilic syndrome with esophageal involvement Reviewed

    Takahashi, K., Sato, H., Tominaga, K., Kohisa, J., Ikarashi, S., Hayashi, K., Miuzno, K., Hashimoto, S., Yokoyama, J., Terai, S.

    Journal of Gastroenterology and Hepatology (Australia)   33 ( 11 )   1817 - 1817   2018.11

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    DOI: 10.1111/jgh.14312

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  • Novel Magnified Single-Balloon Enteroscopy Enables Observation of Jejunal White Spots Associated with Lymphangiectasia. Reviewed

    Tominaga K, Tsuchiya A, Kawata Y, Yokoyama J, Terai S

    Digestive diseases (Basel, Switzerland)   37 ( 2 )   1 - 5   2018.11

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    DOI: 10.1159/000493578

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  • Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice. Reviewed International journal

    Watanabe Y, Tsuchiya A, Seino S, Kawata Y, Kojima Y, Ikarashi S, Starkey Lewis PJ, Lu WY, Kikuta J, Kawai H, Yamagiwa S, Forbes SJ, Ishii M, Terai S

    Stem cells translational medicine   8 ( 3 )   271 - 284   2018.11

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    We describe a novel therapeutic approach for cirrhosis using mesenchymal stem cells (MSCs) and colony-stimulating factor-1-induced bone marrow-derived macrophages (id-BMMs) and analyze the mechanisms underlying fibrosis improvement and regeneration. Mouse MSCs and id-BMMs were cultured from mouse bone marrow and their interactions analyzed in vitro. MSCs, id-BMMs, and a combination therapy using MSCs and id-BMMs were administered to mice with CCl4 -induced cirrhosis. Fibrosis regression, liver regeneration, and liver-migrating host cells were evaluated. Administered cell behavior was also tracked by intravital imaging. In coculture, MSCs induced switching of id-BMMs toward the M2 phenotype with high phagocytic activity. In vivo, the combination therapy reduced liver fibrosis (associated with increased matrix metalloproteinases expression), increased hepatocyte proliferation (associated with increased hepatocyte growth factor, vascular endothelial growth factor, and oncostatin M in the liver), and reduced blood levels of liver enzymes, more effectively than MSCs or id-BMMs monotherapy. Intravital imaging showed that after combination cell administration, a large number of id-BMMs, which phagocytosed hepatocyte debris and were retained in the liver for more than 7 days, along with a few MSCs, the majority of which were trapped in the lung, migrated to the fibrotic area in the liver. Host macrophages and neutrophils infiltrated after combination therapy and contributed to liver fibrosis regression and promoted regeneration along with administered cells. Indirect effector MSCs and direct effector id-BMMs synergistically improved cirrhosis along with host cells in mice. These studies pave the way for new treatments for cirrhosis. Stem Cells Translational Medicine 2019;8:271&284.

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  • 高齢者消化器疾患に対する治療方針 高齢者の術後再建腸管に対するERCPの検討

    水澤 健, 五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   63回   47 - 47   2018.11

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  • 腹部大動脈瘤増大により初めての腸閉塞をきたした腸回転異常症の高齢者の1例

    村松 夏季, 土屋 敦紀, 小田 知友美, 木村 淳史, 保坂 和徳, 木村 成宏, 冨永 顕太郎, 林 和直, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   63回   74 - 74   2018.11

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  • 画像診断の新しいモダリティを用いた診断 MRエラストグラフィーを用いたリスクに応じた肝細胞癌及び門脈大循環シャントのマネージメントの確立に向けて

    薛 徹, 土屋 淳紀, 寺井 崇二

    肝臓   59 ( Suppl.3 )   A850 - A850   2018.11

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  • 原発巣とは真逆なMRI T2所見を呈したぶどう膜悪性黒色腫の多発肝転移の1例

    薛 徹, 土屋 淳紀, 寺井 崇二

    肝臓   59 ( Suppl.3 )   A893 - A893   2018.11

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  • ダブルバルーン内視鏡で診断に至った消化管重複症の成人例

    丹羽 佑輔, 上村 顕也, 小林 隆昌, 高橋 一也, 冨永 顕太郎, 河久 順志, 阿部 聡司, 川合 弘一, 横山 純二, 杉野 英明, 梅津 哉, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   63回・85回   59 - 59   2018.11

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  • 肝疾患と臓器相関 肝疾患における自律神経による臓器間ネットワークの関与

    上村 顕也, 名古屋 拓郎, 寺井 崇二

    肝臓   59 ( Suppl.3 )   A862 - A862   2018.11

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  • Green epithelium revealed by narrow-band imaging (NBI): a feature for practical assessment of extent of gastric cancer after <i>H. pylori</i> eradication. Reviewed

    Yagi K, Nagayama I, Hoshi T, Abe S, Morita SI, Suda T, Hasegawa G, Sato YI, Terai S

    Endoscopy international open   6 ( 11 )   E1289 - E1295   2018.11

  • Usefulness of Capsule Endoscopy and Double-balloon Enteroscopy for the Diagnosis of Multiple Carcinoid Tumors in the Small Intestine: Case Reports and a Literature Review. Reviewed

    Tominaga K, Kamimura K, Yokoyama J, Terai S

    Internal medicine (Tokyo, Japan)   58 ( 5 )   655 - 659   2018.10

  • Gene therapy for pancreatic diseases: Current status Reviewed

    Kamimura, K., Yokoo, T., Terai, S.

    International Journal of Molecular Sciences   19 ( 11 )   2018.10

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    DOI: 10.3390/ijms19113415

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  • 超高齢者における肝硬変診療 Reviewed

    上村顕也, 坂牧僚, 木村成広, 薛徹, 上村博輝, 横尾健, 阿部聡司, 寺井崇二

    消化器・肝臓内科   4 ( 4 )   344 - 347   2018.10

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  • フレイルとサルコペニアについて 進行消化器癌における体組成と予後との関連

    川合 弘一, 小林 隆昌, 中野 応央樹, 五十嵐 聡, 河久 順志, 阿部 聡司, 上村 博輝, 坂牧 僚, 林 和直, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    新潟医学会雑誌   132 ( 10 )   350 - 352   2018.10

  • ステロイド使用例における胆管結石治療の現状

    五十嵐 聡, 林 和直, 河久 順志, 冨永 顕太郎, 高橋 一也, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2086 - 2086   2018.10

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  • 超音波内視鏡における音速補正モードの有用性

    林 和直, 五十嵐 聡, 河久 順志, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2110 - 2110   2018.10

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  • 重篤な基礎疾患を持たないサイトメガロウイルス小腸炎の特徴と小腸内視鏡の有用性

    横山 純二, 冨永 顕太郎, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増大会 )   A760 - A760   2018.10

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  • 炎症性腸疾患患者における血清IgAの検討

    冨永 顕太郎, 横山 純二, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2121 - 2121   2018.10

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  • NASHモデルマウスにおける自律神経系を介した消化管ホルモンの関与

    名古屋 拓郎, 上村 顕也, 井上 良介, 酒井 規裕, 後藤 諒, 高 昌良, 丹羽 佑輔, 坂牧 僚, 中村 由香, 上野 将紀, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増大会 )   A732 - A732   2018.10

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  • Peroral cholangioscopy of nivolumab-related (induced) ulcerative cholangitis in a patient with non-small cell lung cancer Reviewed

    Kuraoka, N., Hara, K., Terai, S., Yatabe, Y., Horio, Y.

    Endoscopy   50 ( 9 )   E259 - E261   2018.9

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    DOI: 10.1055/a-0640-2392

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  • Listeria meningitis during infliximab-based treatment for ulcerative colitis Reviewed

    Tsuchiya, A., Terai, S.

    Internal Medicine   57 ( 17 )   2603 - 2603   2018.9

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    DOI: 10.2169/internalmedicine.0695-18

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  • Disappearance of multiple pancreatic cysts after prednisolone treatment in a patient with autoimmune pancreatitis Reviewed

    Kohisa, J., Tsuchiya, A., Ikemi, M., Terai, S.

    Clinical Case Reports   6 ( 9 )   1898 - 1900   2018.9

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    DOI: 10.1002/ccr3.1737

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  • マウス肝線維化進展予防薬の探索及び効果の検証

    酒井 規裕, 上村 顕也, 後藤 諒, 小川 光平, 坂牧 僚, 阿部 聡司, 榎本 初音, 立木 秀尚, 寺井 崇二

    肝臓   59 ( Suppl.2 )   A723 - A723   2018.9

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  • 消化管疾患と肝疾患の関連-消化管・肝臓間の相互の影響- 自律神経線維による肝,脳,腸の臓器間ネットワークを介した肝切除後の肝再生メカニズムの検討

    上村 顕也, 寺井 崇二

    肝臓   59 ( Suppl.2 )   A609 - A609   2018.9

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  • Diagnosis and management of fibromuscular dysplasia and segmental arterial mediolysis in gastroenterology field: A mini-review. Reviewed International journal

    Ko M, Kamimura K, Ogawa K, Tominaga K, Sakamaki A, Kamimura H, Abe S, Mizuno K, Terai S

    World journal of gastroenterology   24 ( 32 )   3637 - 3649   2018.8

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    The vascular diseases including aneurysm, occlusion, and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients. With the development and improvement of imaging modalities, diagnostic frequency of these vascular diseases in abdominal lesions is increasing even with the small changes in the vasculatures. Among various vascular diseases, fibromuscular dysplasia (FMD) and segmental arterial mediolysis (SAM) are noninflammatory, nonatherosclerotic arterial diseases which need to be diagnosed urgently because these diseases could affect various organs and be lethal if the appropriate management is not provided. However, because FMD and SAM are rare, the cause, prevalence, clinical characteristics including the symptoms, findings in the imaging studies, pathological findings, management, and prognoses have not been systematically summarized. Therefore, there have been neither standard diagnostic criteria nor therapeutic methodologies established, to date. To systematically summarize the information and to compare these disease entities, we have summarized the characteristics of FMD and SAM in the gastroenterological regions by reviewing the cases reported thus far. The information summarized will be helpful for physicians treating these patients in an emergency care unit and for the differential diagnosis of other diseases showing severe abdominal pain.

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  • The Value of <sup>18</sup>F-FDG PET in the Diagnosis of Intertrabecular Vertebral Metastasis in a Small Cell Lung Cancer Patient with a High Serum CEA Level. Reviewed

    Morita S, Suda T, Oda C, Kobayashi M, Hoshi T, Kanefuji T, Yagi K, Hasegawa G, Terai S

    Internal medicine (Tokyo, Japan)   58 ( 3 )   415 - 418   2018.8

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    We encountered a small cell lung cancer (SCLC) patient with intertrabecular vertebral metastasis (IVM). A 59-year-old man was admitted to our hospital with weight loss. 18F-fluorodeoxyglucose positron emission tomography (FDG PET)-CT demonstrated the uptake of fluorodeoxyglucose in the hilum of the left lung and whole-body bones. Despite intensive support, the patient died within a month. Subsequent autopsy revealed a small lesion consisting of small round cells in the left lung. The cancer cells were found to have spread through the replacement of the bone marrow cells while sparing the trabecular bone. This case demonstrated the potential of 18F-FDG PET for detecting IVM in SCLC patients.

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  • Successful treatment of aortic dissection during sorafenib therapy for hepatocellular carcinoma. Reviewed International journal

    Tsuchiya A, Ogawa M, Watanabe Y, Kimura N, Hayashi K, Suda T, Terai S

    Clinical case reports   6 ( 8 )   1643 - 1644   2018.8

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    Our case highlights the need for caution during vascular endothelial growth factor pathway inhibitor (VPI) therapy and for the occurrence of aortic dissection. If Stanford classification type A aortic dissection occurs during VPI therapy, surgical intervention should be considered to prevent cardiac tamponade if the patient's clinical condition permits it.

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  • Gastric Cavernous Hemangioma Resected by Endoscopic Submucosal Dissection. Reviewed

    Watanabe Y, Takahashi K, Yokoyama J, Terai S

    Internal medicine (Tokyo, Japan)   57 ( 15 )   2269 - 2270   2018.8

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  • Potential role of extracellular vesicle-mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy. Reviewed International journal

    Takamasa Ito, Takashi Shiromizu, Shunsuke Ohnishi, Shotaro Suzuki, Katsuhiro Mabe, Akito Hasegawa, Hideyuki Ujiie, Yasuyuki Fujita, Yuichi Sato, Shuji Terai, Mototsugu Kato, Masahiro Asaka, Takeshi Tomonaga, Hiroshi Shimizu, Riichiro Abe

    The Journal of allergy and clinical immunology   142 ( 2 )   672 - 676   2018.8

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  • Rapidly declining skeletal muscle mass predicts poor prognosis of hepatocellular carcinoma treated with transcatheter intra-arterial therapies. Reviewed International journal

    Takamasa Kobayashi, Hirokazu Kawai, Oki Nakano, Satoshi Abe, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai

    BMC cancer   18 ( 1 )   756 - 756   2018.7

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    BACKGROUND: The impact of sarcopenia on the prognosis of patients with hepatocellular carcinoma (HCC) who receive transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcatheter arterial infusion chemotherapy, remains unclear. We investigated the prognostic value of skeletal muscle loss (SML) stratified by cutoffs for sarcopenia and rate of change in skeletal muscle mass over 6 months. METHODS: We retrospectively evaluated 102 patients with HCC treated with transcatheter intra-arterial therapies between 2005 and 2015. Computed tomography images of the third lumbar vertebra (L3) were analyzed to obtain the skeletal muscle area normalized for the height squared, defined as the skeletal muscle index at L3 (L3 SMI), before and 6 months after treatment. Low or high SMI was defined using cutoff values of 42 cm2/m2 in men and 38 cm2/m2 in women. The rate of change in skeletal muscle mass (ΔL3 SMI) over 6 months was calculated. Overall survival (OS) was compared in groups classified by baseline L3 SMI and ΔL3 SMI; prognostic significance was assessed with univariate and multivariate analyses, using Cox proportional hazards models. RESULTS: OS did not differ significantly between groups with low (n = 31) and high (n = 71) SMI at baseline (P = 0.172), but OS was significantly poorer in patients with SML (n = 41), defined as ΔL3 SMI < - 4.6% over 6 months than in those without SML (n = 61, P = 0.018). On multivariate analysis, SML (hazard ratio [HR], 1.675; 95% confidence interval [CI], 1.031-2.721; P = 0.037), serum alpha-fetoprotein ≥20 ng/mL (HR, 2.550; 95% CI, 1.440-4.515; P = 0.001), and maximum tumor diameter ≥ 30 mm (HR, 1.925; 95% CI, 1.166-3.179; P = 0.010) were independent predictors of poor OS. Baseline L3 SMI was not significantly associated with OS (HR, 1.405; 95% CI, 0.861-2.293; P = 0.174). CONCLUSIONS: ΔL3 SMI was an independent prognostic factor in patients with HCC treated with transcatheter intra-arterial therapies. Further study is required to reveal whether prevention of skeletal muscle depletion might be a new therapeutic strategy to contribute to improved clinical outcomes in patients with HCC.

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  • Management decision based on lymphovascular involvement leads to favorable outcomes after endoscopic treatment of esophageal squamous cell carcinoma Reviewed

    Kazuya Takahashi, Satoru Hashimoto, Ken-Ichi Mizuno, Takamasa Kobayashi, Kentaro Tominaga, Hiroki Sato, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Manabu Takeuchi, Junji Yokoyama, Hirokazu Kawai, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    Endoscopy   50 ( 7 )   662 - 670   2018.7

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    DOI: 10.1055/s-0043-124433

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  • A case of inferior vena cava thrombosis caused by compression due to growing giant liver cyst. Reviewed

    Kimura N, Tsuchiya A, Ogawa M, Watanabe Y, Hayashi K, Yokoyama J, Umezu H, Terai S

    Clinical journal of gastroenterology   12 ( 1 )   71 - 75   2018.7

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    We report a case of inferior vena cava (IVC) thrombosis caused by compression by a giant liver cyst. A 68-year-old man with a 1-day history of abdominal pain was referred to another hospital. Ultrasonography (US) and enhanced computed tomography (CT) showed a multilobular cyst on the right liver lobe that had increased to 300 mm in diameter from 90 mm 18 months earlier. Thrombosis was detected in the IVC, which was compressed by the cyst. Percutaneous transhepatic cyst drainage achieved no significant change in size. Cytological analysis from the percutaneous drainage tube fluid showed no evidence of malignancy. He was referred to our hospital for further assessment and treatment. Enhanced US using perfluorobutane, CT, and magnetic resonance imaging showed no tumorous lesions in the cyst. Thus, we diagnosed it as a multilobular cyst with no evidence of malignancy. A 3-week course of heparin resulted in the successful resolution of the thrombosis. Cystectomy was subsequently performed and pathological examination showed a multifocal cyst consisting of central suppurative inflammatory exudation and hemorrhagic material, with no malignancy. This case demonstrates that giant, expanding, non-tumorous cysts can cause IVC thrombosis. Careful treatment using heparin successfully resolved the thrombosis and allowed successful cystectomy.

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  • Anti-Programmed Cell Death-1 Immunotherapy-Related Secondary Sclerosing Cholangitis. Reviewed International journal

    Ogawa K, Kamimura K, Terai S

    Hepatology (Baltimore, Md.)   69 ( 2 )   914 - 916   2018.7

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  • Renal Impairment in Chronic Hepatitis B: A Review. Reviewed International journal

    Hiroteru Kamimura, Toru Setsu, Naruhiro Kimura, Takeshi Yokoo, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai

    Diseases (Basel, Switzerland)   6 ( 2 )   2018.6

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    The liver plays a key role in the metabolism of proteins. Liver dysfunction affects many organs because it communicates with the spleen and all digestive organs through the portal vein. Additionally, the kidney is an organ that is closely related to the liver and is involved in liver diseases. Glomerulonephritis is an important extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. Nucleos(t)ide analog (NA) therapy effectively suppresses HBV replication by inhibiting HBV polymerase, thus decreasing the levels of serum HBV-DNA and delaying the progression of cirrhosis. Although NA therapy is recommended for all patients with chronic HBV infection, regardless of the level of renal dysfunction, there is limited information on NA use in patients with chronic kidney disease. In addition, in patients with end-stage liver cirrhosis, hepatorenal syndrome can be fatal. Hence, we should take into account the stage of impaired renal function in patients with cirrhosis. The aims of this article are to review the epidemiology, clinical presentation, treatment, and prevention of HBV-associated nephropathy.

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  • Eosinophilic Esophageal Myositis (EoEM) Causes Jackhammer Esophagus, Rarely Posing a Problem in the Differential Diagnosis of Eosinophilic Esophagitis Reviewed

    Hiroki Sato, Shuji Terai

    American Journal of Gastroenterology   113 ( 8 )   1 - 2   2018.6

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    DOI: 10.1038/s41395-018-0171-z

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  • Reply to the letter to the editor: Lymph node metastasis of adenocarcinoma and different definitions of sm1 cancer in the esophagus Reviewed

    Ryu Ishihara, Tsuneo Oyama, Seiichiro Abe, Hiroaki Takahashi, Hiroyuki Ono, Junko Fujisaki, Mitsuru Kaise, Kenichi Goda, Kenro Kawada, Tomoyuki Koike, Manabu Takeuchi, Rie Matsuda, Dai Hirasawa, Masayoshi Yamada, Junichi Kodaira, Masaki Tanaka, Masami Omae, Akira Matsui, Takashi Kanesaka, Akiko Takahashi, Shinichi Hirooka, Masahiro Saito, Yosuke Tsuji, Yuki Maeda, Hiroharu Yamashita, Ichiro Oda, Yasuhiko Tomita, Takashi Matsunaga, Shuji Terai, Soji Ozawa, Tatsuyuki Kawano, Yasuyuki Seto

    Journal of Gastroenterology   53 ( 6 )   804 - 805   2018.6

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    DOI: 10.1007/s00535-018-1463-1

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  • Nationwide survey for acute liver failure and late-onset hepatic failure in Japan Reviewed

    Masamitsu Nakao, Nobuaki Nakayama, Yoshihito Uchida, Tomoaki Tomiya, Akio Ido, Isao Sakaida, Osamu Yokosuka, Yasuhiro Takikawa, Kazuaki Inoue, Takuya Genda, Masahito Shimizu, Shuji Terai, Hirohito Tsubouchi, Hajime Takikawa, Satoshi Mochida

    Journal of Gastroenterology   53 ( 6 )   752 - 769   2018.6

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  • IS ENDOSCOPIC SUBMUCOSAL DISSECTION VALUABLE FOR ELDERLY PATIENTS WITH SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA? Reviewed

    Hashimoto Satoru, Mizuno Kenichi, Takahashi Kazuya, Sato Hiroki, Tominaga Kentaro, Kohisa Junji, Ikarashi Satoshi, Hayashi Kazunao, Yokoyama Junji, Terai Shuji

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB287 - AB287   2018.6

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  • Persistent reduction of mucosal-associated invariant T cells in primary biliary cholangitis. Reviewed International journal

    Toru Setsu, Satoshi Yamagiwa, Kentaro Tominaga, Naruhiro Kimura, Hiroki Honda, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Shuji Terai

    Journal of gastroenterology and hepatology   33 ( 6 )   1286 - 1294   2018.6

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    BACKGROUND AND AIM: Mucosal-associated invariant T (MAIT) cells constitute a novel subset of innate-like T lymphocytes characterized by a semi-invariant T-cell receptor repertoire capable of recognizing bacterial products. Considering the abundance of MAIT cells in the liver and the possible association between bacterial infections and primary biliary cholangitis (PBC), we aimed to analyze the involvement of MAIT cells in the immunopathogenesis of PBC. METHODS: Peripheral blood and liver biopsy specimens were collected from 25 patients with PBC and 19 patients with chronic viral hepatitis. Surgically removed liver tissues distant from tumors in patients with metastatic liver tumors were used as controls. Mononuclear cells were separated using Ficoll gradient, and the expression of various markers was investigated by flow cytometry. Cytokine production was investigated using blood MAIT cells after stimulation by anti-CD3/CD28-coupled beads with/without interleukin-7 (IL-7). RESULTS: Mucosal-associated invariant T cells were significantly reduced in both the blood and liver of PBC patients compared with those in controls. MAIT cells in the blood of PBC patients expressed significantly lower levels of activation markers and IL-7 receptor. Moreover, MAIT cells in the blood of PBC patients showed impaired production of cytokines, especially tumor necrosis factor alpha, after in vitro stimulation with IL-7. Interestingly, even after biochemical responses were achieved by ursodeoxycholic acid treatment, the frequencies of MAIT cells did not fully recover to normal levels. CONCLUSIONS: These findings suggested that MAIT cells were activated, exhausted, and persistently depleted in PBC patients even after ursodeoxycholic acid treatment, possibly as a consequence of persistent liver inflammation.

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  • ENDOSCOPIC MANAGEMENT OF UNRESECTABLE MALIGNANT HILAR STRICTURES USING THREADED INSIDE STENTS VERSUS METALLIC STENTS Reviewed

    Hayashi Kazunao, Ikarashi Satoshi, Kohisa Junji, Takahashi Kazuya, Tominaga Kentaro, Mizuno Ken-ichi, Hashimoto Satoru, Yokoyama Junji, Yamagiwa Satoshi, Terai Shuji

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB208 - AB208   2018.6

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  • IS ENDOSCOPIC SUBMUCOSAL DISSECTION A FEASIBLE TREATMENT FOR ESOPHAGOGASTRIC JUNCTION CANCER? Reviewed

    Takahashi Kazuya, Hashimoto Satoru, Mizuno Kenichi, Sato Hiroki, Tominaga Kentaro, Kohisa Junji, Ikarashi Satoshi, Hayashi Kazunao, Yokoyama Junji, Terai Shuji

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB396 - AB397   2018.6

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  • SAFETY AND EFFICACY OF PROPOFOL-BASED SEDATION FOR BALLOON ENTEROSCOPE-ASSISTED ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN ELDERLY PATIENTS Reviewed

    Kohisa Junji, Ikarashi Satoshi, Hayashi Kazunao, Takahashi Kazuya, Tominaga Kentaro, Mizuno Kenichi, Hashimoto Satoru, Yokoyama Junji, Yamagiwa Satoshi, Terai Shuji

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB229 - AB229   2018.6

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  • フランシーン形状針を用いたEUS-FNAの有用性についての検討

    河久 順志, 林 和直, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   34 ( 1 )   73 - 73   2018.6

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  • How do you treat this diversion ileitis and pouchitis? Reviewed

    Kentaro Tominaga, Atsunori Tsuchiya, Junji Yokoyama, Shuji Terai

    Gut   2018.5

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    DOI: 10.1136/gutjnl-2017-315591

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  • Efficacy and safety of rifaximin in Japanese patients with hepatic encephalopathy: A phase II/III, multicenter, randomized, evaluator-blinded, active-controlled trial and a phase III, multicenter, open trial Reviewed

    Kazuyuki Suzuki, Ryujin Endo, Yasuhiro Takikawa, Fuminori Moriyasu, Yutaka Aoyagi, Hisataka Moriwaki, Shuji Terai, Isao Sakaida, Yoshiyuki Sakai, Shuhei Nishiguchi, Toru Ishikawa, Hitoshi Takagi, Atsushi Naganuma, Takuya Genda, Takafumi Ichida, Koichi Takaguchi, Katsuhiko Miyazawa, Kiwamu Okita

    Hepatology Research   48 ( 6 )   411 - 423   2018.5

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    DOI: 10.1111/hepr.13045

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  • Cost-effectiveness of combined serum anti-Helicobacter pylori IgG antibody and serum pepsinogen concentrations for screening for gastric cancer risk in Japan Reviewed

    Shota Saito, Motoi Azumi, Yusuke Muneoka, Katsuhiko Nishino, Takashi Ishikawa, Yuichi Sato, Shuji Terai, Kouhei Akazawa

    European Journal of Health Economics   19 ( 4 )   545 - 555   2018.5

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    DOI: 10.1007/s10198-017-0901-y

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  • Diversion colitis and pouchitis: A mini-review Reviewed

    Kentaro Tominaga, Kenya Kamimura, Kazuya Takahashi, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

    World Journal of Gastroenterology   24 ( 16 )   1734 - 1747   2018.4

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  • Endoscopic ultrasound-guided transmural drainage for subphrenic abscess: Report of two cases and a literature review Reviewed

    Shinichi Morita, Kenya Kamimura, Takeshi Suda, Chiyumi Oda, Takahiro Hoshi, Tsutomu Kanefuji, Kazuyoshi Yagi, Shuji Terai

    BMC Gastroenterology   18 ( 1 )   55   2018.4

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    DOI: 10.1186/s12876-018-0782-2

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  • Clinical outcome of hepatocellular carcinoma can be predicted by the expression of hepatic progenitor cell markers and serum tumour markers. Reviewed International journal

    Satoshi Seino, Atsunori Tsuchiya, Yusuke Watanabe, Yuzo Kawata, Yuichi Kojima, Shunzo Ikarashi, Hiroyuki Yanai, Koji Nakamura, Daisuke Kumaki, Masaaki Hirano, Kazuhiro Funakoshi, Takashi Aono, Takeshi Sakai, Jun Sakata, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Toshifumi Wakai, Shuji Terai

    Oncotarget   9 ( 31 )   21844 - 21860   2018.4

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    The high heterogeneity of hepatocellular carcinomas (HCCs) complicates stratification of HCC patients for treatment. Therefore, it is necessary to establish a comprehensive panel of HCC biomarkers related to tumour behaviour and cancer prognosis. Resected HCCs from 251 patients were stained for hepatic progenitor cell (HPC) markers epithelial cell adhesion molecule (EpCAM), neural cell adhesion molecule (NCAM), delta-like 1 homolog (DLK1), and cytokeratin 19 (CK19). Staining patterns were analysed for their prognostic association with relapse-free survival and overall survival. α-Fetoprotein (AFP), lectin-reactive α-fetoprotein (AFP-L3), and des-γ-carboxy prothrombin (DCP) were assessed as indicators of HPC protein expression. Expression pattern of HPC markers correlated with tumour malignancy indicated by high AFP/AFP-L3 serum levels, more frequent vascular invasion, and poorer tumour differentiation. EpCAM expression, DCP ≥300 mAU/ml, age ≥60, and Child-Pugh score grade B or C were independent prognostic factors of poor outcome and were used in a new scoring system for HCC prognosis after operation. Expression of two or more HPC markers was a significant predictor of poor HCC outcome and serum levels of AFP/AFP-L3 correlated with the expression of HPC proteins. Our study paved the way for further elucidation of the association among HPC markers, serum tumour markers, and HCC clinical outcome for precision medicine.

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  • Autonomic nervous system network and liver regeneration Reviewed

    Kenya Kamimura, Ryosuke Inoue, Takuro Nagoya, Norihiro Sakai, Ryo Goto, Masayoshi Ko, Yusuke Niwa, Shuji Terai

    World Journal of Gastroenterology   24 ( 15 )   1616 - 1621   2018.4

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  • A case of Behçet’s disease with various gastrointestinal findings Reviewed

    Kentaro Tominaga, Kenya Kamimura, Kazuya Takahashi, Junji Yokoyama, Shuji Terai

    Clinical Journal of Gastroenterology   11 ( 5 )   1 - 5   2018.4

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  • Efficacy of EUS for detection of a buried fish bone in the esophagus Reviewed

    Junji Kohisa, Ken-ichi Mizuno, Kazuya Takahashi, Junji Yokoyama, Shuji Terai

    VideoGIE   3 ( 4 )   125 - 126   2018.4

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  • A clinical study of peroral endoscopic myotomy reveals that impaired lower esophageal sphincter relaxation in Achalasia is not only defined by high-resolution manometry Reviewed

    Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai

    PLoS ONE   13 ( 4 )   e0195423   2018.4

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  • Esophageal motility disorders: new perspectives from high-resolution manometry and histopathology Reviewed

    Hiroki Sato, Kazuya Takahashi, Ken-ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Go Hasegawa, Shuji Terai

    Journal of Gastroenterology   53 ( 4 )   484 - 493   2018.4

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  • Ombitasvir–Paritaprevir–Ritonavir Therapy in a Kidney Transplant Recipient With Chronic Hepatitis C Virus Genotype 1 Infection: A Case Report on the Importance of Considering Drug–Drug Interactions and Monitoring Cyclosporine Levels Reviewed

    S. Takeuchi, M. Takamura, T. Yoshida, K. Takahashi, K. Hayashi, S. Hashimoto, S. Yamagiwa, M. Tasaki, Y. Nakagawa, K. Saito, Y. Tanabe, Y. Tomita, S. Terai

    Transplantation Proceedings   50 ( 3 )   884 - 886   2018.4

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  • 当院における非切除悪性肝門部胆管狭窄に対する内視鏡的ステント留置術の現状と課題

    林 和直, 五十嵐 聡, 河久 順志, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.1 )   797 - 797   2018.4

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  • Bleeding from a Small-Intestinal Ulcer Associated with Chronic Hepatitis C. Reviewed International journal

    Hiroteru Kamimura, Satoshi Yamagiwa, Iwasaki Tomohiro, Wataru Higuchi, Norio Ogata, Atsunori Tsuchiya, Kenya Kamimura, Masaaki Takamura, Hirokazu Kawai, Shuji Terai

    The American journal of case reports   19   234 - 237   2018.3

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    BACKGROUND Hepatitis C virus infection is probably the most common chronic viral infection and affects an estimated 180 million people worldwide. Extrahepatic manifestations are well recognized among patients with chronic HCV infection. CASE REPORT We report a case of melena occurring in a 69-year-old Japanese man who had been diagnosed with CHC and who was treated with antiviral therapy. CONCLUSIONS Finally, he was diagnosed with multiple small intestine ulcers in a short time. We herein report the case of HCV with rapidly developing small intestine ulcers.

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  • Proposed diagnostic criteria for acute-on-chronic liver failure in Japan Reviewed

    Satoshi Mochida, Nobuaki Nakayama, Akio Ido, Kazuaki Inoue, Takuya Genda, Yasuhiro Takikawa, Isao Sakaida, Shuji Terai, Osamu Yokosuka, Masahito Shimizu, Hajime Takikawa

    Hepatology Research   48 ( 4 )   219 - 224   2018.3

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  • A multicenter pilot survey to clarify the clinical features of patients with acute-on-chronic liver failure in Japan Reviewed

    Nobuaki Nakayama, Hayato Uemura, Yoshihito Uchida, Tomoaki Tomiya, Akio Ido, Kazuaki Inoue, Takuya Genda, Yasuhiro Takikawa, Isao Sakaida, Shuji Terai, Osamu Yokosuka, Masahito Shimizu, Hajime Takikawa, Satoshi Mochida

    Hepatology Research   48 ( 4 )   303 - 312   2018.3

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  • Effect of a neural relay on liver regeneration in mice: activation of serotonin release from the gastrointestinal tract Reviewed

    Ryosuke Inoue, Kenya Kamimura, Takuro Nagoya, Norihiro Sakai, Takeshi Yokoo, Ryo Goto, Kohei Ogawa, Yoko Shinagawa-Kobayashi, Yukari Watanabe-Mori, Akira Sakamaki, Satoshi Abe, Hiroteru Kamimura, Norio Miyamura, Hiroshi Nishina, Shuji Terai

    FEBS Open Bio   8 ( 3 )   449 - 460   2018.3

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    DOI: 10.1002/2211-5463.12382

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  • Gastric Metastasis From Uveal Melanoma. Reviewed International journal

    Morita S, Suda T, Terai S

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   17 ( 7 )   A20   2018.3

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  • 急性膵炎診療Up-to-date 重症急性膵炎におけるwalled-off necrosis合併のリスク因子に関する多施設共同後方視的研究

    五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A176 - A176   2018.3

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  • 切除不能膵癌における好中球リンパ球比と他の炎症・栄養指標による予後予測能の比較検討

    中野 応央樹, 川合 弘一, 小林 隆昌, 河久 順志, 五十嵐 聡, 林 和直, 横山 順二, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A373 - A373   2018.3

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  • Effect of histidine on sorafenib-induced vascular damage: Analysis using novel medaka fish model Reviewed

    Yoko Shinagawa-Kobayashi, Kenya Kamimura, Ryo Goto, Kohei Ogawa, Ryosuke Inoue, Takeshi Yokoo, Norihiro Sakai, Takuro Nagoya, Akira Sakamaki, Satoshi Abe, Soichi Sugitani, Masahiko Yanagi, Koichi Fujisawa, Yoshizu Nozawa, Naoto Koyama, Hiroshi Nishina, Makoto Furutani-Seiki, Isao Sakaida, Shuji Terai

    Biochemical and Biophysical Research Communications   496 ( 2 )   556 - 561   2018.2

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    DOI: 10.1016/j.bbrc.2018.01.057

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  • A case of panenteritis with massive IgG4-positive plasma cell infiltration developed 26 years after total proctocolectomy for ulcerative colitis Reviewed

    Kentaro Tominaga, Atsunori Tsuchiya, Yutaka Honda, Tatsuya Abe, Junji Yokoyama, Hajime Umezu, Shuji Terai

    American Journal of Gastroenterology   113 ( 2 )   173   2018.2

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    DOI: 10.1038/ajg.2017.481

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  • Response criteria of tolvaptan for the treatment of hepatic edema Reviewed

    Yasunari Hiramine, Haruki Uojima, Hiroyuki Nakanishi, Akira Hiramatsu, Takuya Iwamoto, Mutsuumi Kimura, Hideto Kawaratani, Shuji Terai, Hitoshi Yoshiji, Hirofumi Uto, Isao Sakaida, Namiki Izumi, Kiwamu Okita, Kazuhiko Koike

    Journal of Gastroenterology   53 ( 2 )   258 - 268   2018.2

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    DOI: 10.1007/s00535-017-1366-6

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  • The factors influencing long-term outcomes of stenting for malignant colorectal obstruction in elderly group in community medicine Reviewed

    Michitaka Imai, Kenya Kamimura, Yoshifumi Takahashi, Toshihiro Sato, Osamu Isokawa, Masaki Maruyama, Takamasa Kobayashi, Kazunao Hayashi, Shuji Terai

    International Journal of Colorectal Disease   33 ( 2 )   189 - 197   2018.2

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    DOI: 10.1007/s00384-017-2946-x

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  • Possible involvement of chemokine C-C receptor 7−programmed cell death-1+ follicular helper T-cell subset in the pathogenesis of autoimmune hepatitis Reviewed

    Naruhiro Kimura, Satoshi Yamagiwa, Tomoyuki Sugano, Toru Setsu, Kentaro Tominaga, Hiroteru Kamimura, Masaaki Takamura, Shuji Terai

    Journal of Gastroenterology and Hepatology (Australia)   33 ( 1 )   298 - 306   2018.1

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    DOI: 10.1111/jgh.13844

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  • Full-layer mucosal histology in achalasia: Histological epithelial wave is characteristic in "pinstripe pattern"-positive achalasia. Reviewed

    Sato H, Takahashi K, Nakajima N, Hasegawa G, Mizuno K, Hashimoto S, Ikarashi S, Hayashi K, Honda Y, Yokoyama J, Sato Y, Terai S

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society   30 ( 1 )   e13168 - e13168   2018.1

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  • Development of Clinically Applicable Liver-specific Nucleic Acids Delivery Invited Reviewed

    Kamimura Kenya

    BIO Clinica   33 ( 1 )   34 - 38   2018.1

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    Terai, S.

    Drug Delivery System   33 ( 5 )   2018

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    DOI: 10.2745/dds.33.368

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  • Gastrointestinal: A rare case of concomitant type III achalasia and chronic idiopathic intestinal pseudo-obstruction

    Sato, H., Abe, H., Nagashima, A., Yokoyama, J., Terai, S.

    Journal of Gastroenterology and Hepatology (Australia)   33 ( 3 )   559 - 559   2018

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    DOI: 10.1111/jgh.13980

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  • Exploration for cell sources for liver regenerative medicine: “CLiP” as a dawn of cell transplantation therapy

    Hosaka, K., Katsuda, T., Terai, S., Ochiya, T.

    Stem Cells and Cancer in Hepatology: From the Essentials to Application   2018

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    DOI: 10.1016/B978-0-12-812301-0.00005-0

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  • Successful closure with over-the-scope clip of an iatrogenic duodenal perforation due to endoscopic ultrasonography

    Morita, S., Suda, T., Oda, C., Hoshi, T., Kanefuji, T., Yagi, K., Terai, S.

    Endoscopic Forum for Digestive Disease   34 ( 1 )   2018

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  • Specific gastric blood vessels in sinistral portal hypertension Reviewed

    Hiroteru Kamimura, Toru Ishikawa, Noriko Ishihara, Shuji Terai

    Internal Medicine   57 ( 7 )   1053 - 1054   2018

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    DOI: 10.2169/internalmedicine.9699-17

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  • Prognostic value of subcutaneous adipose tissue volume in hepatocellular carcinoma treated with transcatheter intra-arterial therapy. Reviewed International journal

    Takamasa Kobayashi, Hirokazu Kawai, Oki Nakano, Satoshi Abe, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai

    Cancer management and research   10   2231 - 2239   2018

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    Background: Prognosis of patients with hepatocellular carcinoma (HCC) who undergo transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcatheter arterial infusion chemotherapy, is affected by many clinical factors including liver function and tumor progression. However, the effect of body composition such as skeletal muscle and visceral and subcutaneous adipose tissues (VAT and SAT, respectively) on the prognosis of these patients remains unclear. We investigated the prognostic value of body composition in HCC patients treated with transcatheter intra-arterial therapies. Patients and methods: This study retrospectively evaluated 100 HCC patients treated with transcatheter intra-arterial therapies between 2005 and 2015. Areas of skeletal muscle, VAT, and SAT were measured on computed tomography images at third lumbar vertebra level and normalized by the height squared to calculate the skeletal muscle index, VAT index, and SAT index (SATI). The visceral to subcutaneous adipose tissue area ratio was also calculated. Overall survival (OS) was compared between high- and low-index groups for each body composition. Furthermore, prognostic significance was assessed by univariate and multivariate analyses using Cox proportional hazards models. Results: Among the body composition indexes, only SATI could significantly differentiate OS (p=0.012). Multivariate analysis showed that SATI (low- vs. high-SATI: HR, 2.065; 95% CI, 1.187-3.593; p=0.010), serum albumin (<3.5 vs. ≥3.5 g/dL; HR, 2.007; 95% CI, 1.037-3.886; p=0.039), serum alpha-fetoprotein (<20 vs. ≥20 ng/mL; HR, 0.311; 95% CI, 0.179-0.540; p<0.001), and Modified Response Evaluation Criteria in Solid Tumors assessment (complete response+partial response+stable disease vs. progressive disease; HR, 0.392; 95% CI, 0.221-0.696; p=0.001) were indicated as independent prognostic factors for OS. Conclusion: High SAT volume is associated with better survival outcomes in HCC patients treated with transcatheter intra-arterial therapies. Elucidation of the mechanisms regulating SAT volume may offer a new therapeutic strategy for these patients.

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  • Dynamics of basal lamina fenestrations in the rat intestinal villous epithelium in response to dietary conditions Reviewed

    Rie Azumi, Keisuke Morita, Yusuke Mizutani, Manabu Hayatsu, Shuji Terai, Tatsuo Ushiki

    Biomedical Research (Japan)   39 ( 2 )   65 - 74   2018

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  • A rare case of concomitant type III achalasia and chronic idiopathic intestinal pseudo-obstruction. Reviewed

    Sato H, Abe H, Nagashima A, Yokoyama J, Terai S

    J Gastroenterol Hepatol   33 ( 3 )   559   2018

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  • Effective prevention of sorafenib-induced hand-foot syndrome by dried-bonito broth. Reviewed International journal

    Kenya Kamimura, Yoko Shinagawa-Kobayashi, Ryo Goto, Kohei Ogawa, Takeshi Yokoo, Akira Sakamaki, Satoshi Abe, Hiroteru Kamimura, Takeshi Suda, Hiroshi Baba, Takayuki Tanaka, Yoshizu Nozawa, Naoto Koyama, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Yutaka Aoyagi, Shuji Terai

    Cancer management and research   10   805 - 813   2018

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    Background: Sorafenib (SOR) is a molecular medicine that prolongs the survival of patients with hepatocellular carcinoma (HCC). Therefore, the management of side effects is essential for the longer period of continuous medication. Among the various side effects, hand-foot syndrome (HFS) is the most common, occurring in 30%-50% of patients, and often results in discontinuation of the SOR medication. However, its mechanism has not been clarified, and no effective prevention method has been reported for the symptoms. Therefore, this study aimed to analyze its mechanism and to develop an effective prevention regimen for the symptoms. Materials and methods: To assess the mechanism of SOR-induced HFS, the peripheral blood flow in the hand and foot was carefully monitored by Doppler ultrasound, thermography, and laser speckle flowgraphy in the cases treated with SOR and its contribution was assessed. Then, the effect of dried-bonito broth (DBB), which was reported to improve peripheral blood flow, on the prevention of the symptom was examined by monitoring its occurrence and the peripheral blood flow. Results: A total of 25 patients were enrolled in this study. In all, eight patients developed HFS, and all cases showed a significant decrease in the peripheral blood flow. DBB contributed to an increase in the flow (p = 0.009) and significantly decreased occurrence of HFS (p = 0.005) than control. Multivariable analysis showed that the ingestion of DBB is a significant independent contributor to HFS-free survival period (p = 0.035). Conclusion: The mechanism of SOR-induced HFS involves a decrease in the peripheral blood flow, and the ingestion of DBB effectively prevents the development of the syndrome by maintaining the flow.

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  • A Case of Enteritis Induced by Nivolumab Reviewed

    Takamasa Kobayashi, Kazuya Takahashi, Shuji Terai

    Clinical Gastroenterology and Hepatology   2018

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    DOI: 10.1016/j.cgh.2018.03.005

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  • Jackhammer esophagus accompanied by esophageal intramural pseudodiverticulosis Reviewed

    Kazuya Takahashi, Satoshi Ikarashi, Junji Yokoyama, Shuji Terai

    Internal Medicine   57 ( 7 )   1051 - 1052   2018

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    DOI: 10.2169/internalmedicine.9734-17

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  • Antireflux Metal Stent for Initial Treatment of Malignant Distal Biliary Obstruction Reviewed

    Shinichi Morita, Yasuaki Arai, Shunsuke Sugawara, Miyuki Sone, Yasunari Sakamoto, Takuji Okusaka, Shigetaka Yoshinaga, Yutaka Saito, Shuji Terai

    Gastroenterology Research and Practice   2018   3805173   2018

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    DOI: 10.1155/2018/3805173

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  • Gastric Cancer after H. pylori Eradication therapy develops in the Intermediate Zone. Relationship to Spasmolytic Polypeptide-Expressing Metaplasia Reviewed

    Kazuyoshi Yagi, Itsuo Nagayama, Takahiro Hoshi, Satoshi Abe, Shinichi Morita, Takeshi Suda, Yu-ichi Sato, Shuji Terai

    Open Access J Surg   9   1 - 6   2018

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  • Eosinophilic esophagitis in Japanese patients: A mild and slow-progressing disorder. Reviewed International journal

    Hiroki Sato, Terasu Honma, Yujiro Nozawa, Takashi Owaki, Michitaka Imai, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Toru Ishikawa, Toshiaki Yoshida, Shuji Terai

    PloS one   13 ( 11 )   e0206621   2018

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    BACKGROUND AND AIM: Awareness of eosinophilic esophagitis (EoE) has gradually increased in Japan, therefore the characteristics of this disease in the Japanese patient population need to be elucidated. This study aimed to investigate the features of EoE in the Japanese population. METHODS: During a 2-year period, all gastrointestinal endoscopies were performed with maximum attention being paid to identify EoE through endoscopic findings. Clinical features and findings were analyzed among this population. RESULTS: Among a total of 8589 patients (general gastrointestinal endoscopy, performed for evaluation of symptoms or disease follow-up: 3669; medical check-up endoscopy, routinely performed in asymptomatic patients: 4920), 17 patients (0.20%) were diagnosed with esophageal eosinophilia (mean age ± standard deviation: 44±11.9 years; 1 female). Only 6 patients with esophageal eosinophilia were diagnosed by general gastrointestinal endoscopy; among them, 3 patients had dysphagia and 3 were asymptomatic. The remaining 11 patients were diagnosed by medical check-up endoscopy. All patients were treated with a proton pump inhibitor (PPI); 5 were diagnosed with EoE and 12 with PPI responsive esophageal eosinophilia. Chronological endoscopy analysis showed that EoE findings could be observed for a mean of 6.1 years prior to diagnosis, and the disease did not significantly progress in severity. CONCLUSIONS: Most Japanese patients with EoE have mild and slowly progressing disease, which can be diagnosed when close attention is paid to the endoscopic findings. Medical check-up endoscopy in Japan could be a great opportunity for the early diagnosis of EoE.

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  • A Case of Pancreatic Schwannoma Diagnosed Preoperatively by Endoscopic Ultrasonography-Guided Fine Needle Aspiration and Treated with Laparoscopic Surgery. Reviewed International journal

    Hayashi K, Tsuchiya A, Ikarashi S, Takizawa K, Terai S

    Journal of pancreatic cancer   4 ( 1 )   7 - 10   2018

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    Background: Pancreatic tumors are often difficult to diagnose in atypical cases, and a pancreatic schwannoma is very rare. We present a case of pancreatic schwannoma with calcification diagnosed preoperatively by endoscopic ultrasonography (EUS)-guided fine needle aspiration (FNA) and treated with laparoscopic distal pancreatectomy. Presentation: A 72-year-old-woman was admitted to our hospital due to a 6 × 4.5 cm large tumor in the pancreatic tail. Imaging modalities revealed that the tumor was hypovascular and gradually enhanced with calcification, but was without cystic lesions. EUS revealed the tumor had a clear boundary with a low echoic mass. EUS-FNA was performed and spindle-shaped cells that were immunopositive for S-100 and negative for c-kit, CD34, and desmin were detected, resulting in a diagnosis of schwannoma. Laparoscopic distal pancreatectomy with splenectomy was safely performed without recurrence for a year. Conclusions: Schwannoma is very rare; however, characteristics of the tumor, such as calcification, can help the diagnosis and, if possible, EUS-FNA should be performed for an appropriate treatment decision.

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  • Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor. Reviewed International journal

    Hayashi K, Kamimura K, Hosaka K, Ikarashi S, Kohisa J, Takahashi K, Tominaga K, Mizuno K, Hashimoto S, Yokoyama J, Yamagiwa S, Takizawa K, Wakai T, Umezu H, Terai S

    World journal of gastrointestinal endoscopy   9 ( 12 )   583 - 589   2017.12

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    Duodenal gastrointestinal stromal tumors (GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure.

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  • Effect of Helicobacter pylori eradication on elder cases: Observational study in community-based medicine Reviewed

    Masaki Maruyama, Kenya Kamimura, Ayako Hoshiyama, Koki Hoshiyama, Mari Hoshiyama, Yoshihiro Hoshiyama, Shuji Terai

    WORLD JOURNAL OF CLINICAL CASES   5 ( 12 )   412 - 418   2017.12

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  • Efficacy and Safety of Pancreas-Targeted Hydrodynamic Gene Delivery in Rats Reviewed

    Kohei Ogawa, Kenya Kamimura, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Norihiro Sakai, Takuro Nagoya, Akira Sakamaki, Satoshi Abe, Kazunao Hayashi, Satoshi Ikarashi, Junji Kohisa, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   9   80 - 88   2017.12

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  • Changes in esophageal motility after endoscopic submucosal dissection for superficial esophageal cancer: a high-resolution manometry study Reviewed

    K. Takahashi, Y. Sato, M. Takeuchi, H. Sato, N. Nakajima, S. Ikarashi, K. Hayashi, K. -I. Mizuno, Y. Honda, S. Hashimoto, J. Yokoyama, S. Terai

    DISEASES OF THE ESOPHAGUS   30 ( 11 )   2017.11

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  • 【臓器間ネットワークからみた肝胆膵の恒常性とその破綻】 臓器間ネットワークの破綻による疾患 自律神経線維が肝再生に与えるインパクト

    上村 顕也, 井上 良介, 名古屋 拓郎, 酒井 規裕, 寺井 崇二

    肝・胆・膵   75 ( 5 )   967 - 972   2017.11

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  • Changes in esophageal motility after endoscopic submucosal dissection for superficial esophageal cancer: a high-resolution manometry study. Reviewed

    Takahashi K, Sato Y, Takeuchi M, Sato H, Nakajima N, Ikarashi S, Hayashi K, Mizuno KI, Honda Y, Hashimoto S, Yokoyama J, Terai S

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus   30 ( 11 )   1 - 8   2017.11

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  • Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma Reviewed

    Hiroki Honda, Masaaki Takamura, Satoshi Yamagiwa, Takuya Genda, Ryoko Horigome, Naruhiro Kimura, Toru Setsu, Kentaro Tominaga, Hiroteru Kamimura, Yasunobu Matsuda, Toshifumi Wakai, Yutaka Aoyagi, Shuji Terai

    SCIENTIFIC REPORTS   7 ( 1 )   15485   2017.11

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  • Intraductal Papillary Neoplasm of the Bile Duct: A Rare Liver Tumor Complicated by Malignancy Reviewed

    Kentaro Tominaga, Kenya Kamimura, Akira Sakamaki, Shuji Terai

    HEPATOLOGY   66 ( 5 )   1695 - 1697   2017.11

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  • Magnifying image-enhanced endoscopy for collagenous colitis. Reviewed

    Kobayashi M, Hoshi T, Morita SI, Kanefuji T, Suda T, Hasegawa G, Terai S

    Endoscopy international open   5 ( 11 )   E1069 - E1073   2017.11

  • Live image and mechanistic analysis of Mesenchymal stem cells (MSCs) and induced bone marrow derived macrophages (id-BMMs) combination therapy for liver cirrhosis in mice Reviewed

    Yusuke Watanabe, Atsunori Tsuchiya, Satoshi Seino, Syunzou Ikarashi, Suguru Takeuchi, Takayuki Watanabe, Kenya Kamimura, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai

    HEPATOLOGY   66   76A - 76A   2017.10

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  • Usefulness of follicular helper T cell subset frequencies in the diagnosis of autoimmune hepatitis Reviewed

    Naruhiro Kimura, Satoshi Yamagiwa, Ryoko Horigome, Hiroteru Kamimura, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Shuji Terai

    HEPATOLOGY   66   687A - 688A   2017.10

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  • Persistent reduction of mucosal-associated invariant T cells in primary biliary cholangitis Reviewed

    Toru Setsu, Satoshi Yamagiwa, Naruhiro Kimura, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Shuji Terai

    HEPATOLOGY   66   166A - 166A   2017.10

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  • Effectiveness and safety of tolvaptan in liver cirrhosis patients with edema: Interim results of post-marketing surveillance of tolvaptan in liver cirrhosis (START study) Reviewed

    Isao Sakaida, Shuji Terai, Masayuki Kurosaki, Moriyoshi Yasuda, Mitsuru Okada, Kosuke Bando, Yasuhiko Fukuta

    HEPATOLOGY RESEARCH   47 ( 11 )   1137 - 1146   2017.10

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  • A Case of Hepatorenal Syndrome and Abdominal Compartment Syndrome with High Renal Congestion. Reviewed International journal

    Hiroteru Kamimura, Takayuki Watanabe, Tomoyuki Sugano, Nao Nakajima, Junji Yokoyama, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Takashi Kato, Gen Watanabe, Satoshi Yamagiwa, Shuji Terai

    The American journal of case reports   18   1000 - 1004   2017.9

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    BACKGROUND Hepatorenal syndrome (HRS) is a reversible renal impairment that occurs in patients with acute liver failure and advanced liver cirrhosis. HRS is due to a renal vasoconstriction that results from extreme vasodilatation. It is therefore a functional disorder, not associated with structural kidney damage. On the other hand, end-stage liver diseases are often complicated by massive ascites. Massive ascites may cause abdominal compartment syndrome (ACS), which includes impairment of renal blood flow, but there are no reports indicating that kidney lesions caused by ACS may pathologically contribute to end-stage liver diseases. CASE REPORT A 40-year-old man with acute liver failure was admitted to our hospital. He was diagnosed with type 1 HRS and showed ACS at the same time. He died 30 days after admission. There were signs of congestion in the kidneys upon dissection and advanced erythroid fullness in the renal tubules. CONCLUSIONS We report an autopsy case with HRS and ACS diagnosed with a clinical and histopathological consideration of liver and kidney. Further clinical studies are needed to improve management of renal failure in patients with acute liver failure and advanced liver cirrhosis.

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  • A canine liver fibrosis model to develop a therapy for liver cirrhosis using cultured bone marrow-derived cells. Reviewed International journal

    Takashi Matsuda, Taro Takami, Ryo Sasaki, Tatsuro Nishimura, Yuki Aibe, Bruno Diaz Paredes, Luiz Fernando Quintanilha, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Naoki Yamamoto, Kenji Tani, Shuji Terai, Yasuho Taura, Isao Sakaida

    Hepatology communications   1 ( 7 )   691 - 703   2017.9

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    We have been developing a therapy for liver cirrhosis using cultured autologous bone marrow-derived mesenchymal stem cells (BMSCs). Before human clinical trials can be considered, the safety and efficacy of BMSC infusion in medium to large animals must be confirmed; thus, we developed a canine liver fibrosis model. A small amount of bone marrow fluid was aspirated from the canine humerus to assess the characteristics of BMSCs. We implanted a venous catheter in the stomach and a subcutaneous infusion port in the back of the neck of each canine. Repeated injection of CCl4 through the catheter was performed to induce liver cirrhosis. After 10 weeks of CCl4 injection, eight canines were equally divided into two groups: no cell infusion (control group) and autologous BMSC infusion through the peripheral vein (BMSC group). A variety of assays were carried out before and 4 weeks after the infusion. The area of liver fibrosis stained with sirius red was significantly reduced in the BMSC group 4 weeks after BMSC infusion, consistent with a significantly shortened half-life of indocyanine green and improved liver function. Conclusion: We established a useful canine liver fibrosis model and confirmed that cultured autologous BMSC infusion improved liver fibrosis without adverse effects. (Hepatology Communications 2017;1:691-703).

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  • A Huge Abdominal Tumor Abdominal Abscess Reviewed

    Norihiro Sakai, Kenya Kamimura, Shuji Terai

    GASTROENTEROLOGY   153 ( 3 )   E5 - E6   2017.9

  • HHMの肝発癌における分子生物学的メカニズムの解明

    小川 光平, 上村 顕也, 後藤 諒, 井上 良介, 品川 陽子, 酒井 規裕, 名古屋 拓郎, 小林 雄司, 阿部 寛幸, 阿部 聡司, 坂牧 僚, 横尾 健, 川合 弘一, 山際 訓, 高見 太郎, 山本 直樹, 坂井田 功, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増大会 )   A732 - A732   2017.9

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  • Innovative therapeutic endoscopy 膵仮性嚢胞・感染性WONに対する内視鏡的治療 重症急性膵炎後Walled-off necrosisの自然軽快に関連する因子

    五十嵐 聡, 林 和直, 寺井 崇二

    Gastroenterological Endoscopy   59 ( Suppl.2 )   2103 - 2103   2017.9

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  • Innovative therapeutic endoscopy 膵仮性嚢胞・感染性WONに対する内視鏡的治療 重症急性膵炎後Walled-off necrosisの自然軽快に関連する因子

    五十嵐 聡, 林 和直, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増大会 )   A689 - A689   2017.9

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  • 当院におけるBordeline resectable膵癌の治療の現況

    林 和直, 五十嵐 聡, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増大会 )   A832 - A832   2017.9

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  • YAP determines the cell fate of injured mouse hepatocytes in vivo (vol 8, 16017, 2017) Reviewed

    Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina

    NATURE COMMUNICATIONS   8   16146   2017.8

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  • An Automated Self-Learning Quantification System to Identify Visible Areas in Capsule Endoscopy Images Reviewed

    Shinichi Hashimoto, Hiroyuki Ogihara, Masato Suenaga, Yusuke Fujita, Shuji Terai, Yoshihiko Hamamoto, Isao Sakaida

    JOURNAL OF MEDICAL SYSTEMS   41 ( 8 )   119   2017.8

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    DOI: 10.1007/s10916-017-0769-5

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  • YAP determines the cell fate of injured mouse hepatocytes in vivo Reviewed

    Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina

    NATURE COMMUNICATIONS   8   1 - 9   2017.7

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  • The use of clip anchoring to ensure safe transgastric puncture during endoscopic ultrasound-guided transmural drainage Reviewed

    Shinichi Morita, Kazuo Hara, Takeshi Suda, Susumu Hijioka, Nozomi Okuno, Masaaki Kobayashi, Shuji Terai

    ENDOSCOPY   49 ( 7 )   E186 - E187   2017.7

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  • Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population Reviewed

    Ryu Ishihara, Tsuneo Oyama, Seiichiro Abe, Hiroaki Takahashi, Hiroyuki Ono, Junko Fujisaki, Mitsuru Kaise, Kenichi Goda, Kenro Kawada, Tomoyuki Koike, Manabu Takeuchi, Rie Matsuda, Dai Hirasawa, Masayoshi Yamada, Junichi Kodaira, Masaki Tanaka, Masami Omae, Akira Matsui, Takashi Kanesaka, Akiko Takahashi, Shinichi Hirooka, Masahiro Saito, Yosuke Tsuji, Yuki Maeda, Hiroharu Yamashita, Ichiro Oda, Yasuhiko Tomita, Takashi Matsunaga, Shuji Terai, Soji Ozawa, Tatsuyuki Kawano, Yasuyuki Seto

    JOURNAL OF GASTROENTEROLOGY   52 ( 7 )   800 - 808   2017.7

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    DOI: 10.1007/s00535-016-1275-0

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  • Lusutrombopag increases hematocytes in a compensated liver cirrhosis patient Reviewed

    Akira Sakamaki, Takayuki Watanabe, Satoshi Abe, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    Clinical Journal of Gastroenterology   10 ( 3 )   261 - 264   2017.6

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    DOI: 10.1007/s12328-017-0735-2

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  • Spontaneous regression of hepatocellular carcinoma: A mini-review Reviewed

    Akira Sakamaki, Kenya Kamimura, Satoshi Abe, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   23 ( 21 )   3797 - 3804   2017.6

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  • Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver Reviewed

    Koichi Fujisawa, Taro Takami, Aya Matsuzaki, Toshihiko Matsumoto, Naoki Yamamoto, Shuji Terai, Isao Sakaida

    SCIENTIFIC REPORTS   7 ( 1 )   2749   2017.6

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    DOI: 10.1038/s41598-017-02924-5

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  • Long-term efficacy and safety of nalfurafine hydrochloride on pruritus in chronic liver disease patients: Patient-reported outcome based analyses Reviewed

    Kenya Kamimura, Takeshi Yokoo, Hiroteru Kamimura, Akira Sakamaki, Satoshi Abe, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    PLOS ONE   12 ( 6 )   e0178991   2017.6

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  • Effect of double platinum agents, combination of miriplatintransarterial oily chemoembolization and cisplatinhepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma: Report of two cases Reviewed

    Kohei Ogawa, Kenya Kamimura, Yukari Watanabe, Yosuke Motai, Daisuke Kumaki, Ryoya Seki, Akira Sakamaki, Satoshi Abe, Hirokazu Kawai, Takeshi Suda, Satoshi Yamagiwa, Shuji Terai

    WORLD JOURNAL OF CLINICAL CASES   5 ( 6 )   238 - 246   2017.6

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    DOI: 10.12998/wjcc.v5.i6.238

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  • Prevention of esophageal stricture after endoscopic submucosal dissection using RNA-based silencing of carbohydrate sulfo-transferase 15 in a porcine model Reviewed

    Hiroki Sato, Seiji Sagara, Nao Nakajima, Teppei Akimoto, Kenji Suzuki, Hiroyuki Yoneyama, Shuji Terai, Naohisa Yahagi

    ENDOSCOPY   49 ( 5 )   491 - 497   2017.5

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    DOI: 10.1055/s-0042-123189

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  • Transhepatic arterial infusion chemotherapy using a combination of miriplatin and CDDP powder versus miriplatin alone in the treatment of hepatocellular carcinoma: a randomized controlled trial Reviewed

    Kenya Kamimura, Takeshi Suda, Takeshi Yokoo, Hiroteru Kamimura, Tsutomu Kanefuji, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Satoshi Yamagiwa, Shuji Terai

    BMC CANCER   17 ( 1 )   322   2017.5

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    DOI: 10.1186/s12885-017-3320-7

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  • Development and use of a non-biomaterial model for hands-on training of endoscopic procedures Reviewed

    Hiroki Sato, Ken-Ichi Mizuno, Yuichi Sato, Satoru Hashimoto, Kazunao Hayashi, Satoshi Ikarashi, Yutaka Honda, Junji Yokoyama, Shuji Terai

    Annals of Translational Medicine   5 ( 8 )   182   2017.4

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    DOI: 10.21037/atm.2017.01.27

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  • Herpes virus reactivation during and after direct-acting antiviral therapy for hepatitis C virus infection Reviewed

    Takeshi Yokoo, Atsunori Tsuchiya, Soichi Sugitani, Shuji Terai

    DIGESTIVE AND LIVER DISEASE   49 ( 4 )   453 - 454   2017.4

  • Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis Reviewed

    Hiroki Sato, Nao Nakajima, Kazuya Takahashi, Go Hasegawa, Ken-ichi Mizuno, Satoru Hashimoto, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   23 ( 13 )   2414 - 2423   2017.4

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    DOI: 10.3748/wjg.v23.i13.2414

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  • Long-term outcomes of colorectal endoscopic submucosal dissection in elderly patients Reviewed

    Yoshifumi Takahashi, Ken-ichi Mizuno, Kazuya Takahashi, Hiroki Sato, Satoru Hashimoto, Manabu Takeuchi, Masaaki Kobayashi, Junji Yokoyama, Yuichi Sato, Shuji Terai

    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE   32 ( 4 )   567 - 573   2017.4

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    DOI: 10.1007/s00384-016-2719-y

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  • HHMはDNA損傷ストレスに対する応答機構を介して肝発癌抑制に寄与する

    小川 光平, 上村 顕也, 後藤 諒, 井上 良介, 品川 陽子, 阿部 寛幸, 阿部 聡司, 坂牧 僚, 横尾 健, 川合 弘一, 山際 訓, 高見 太郎, 山本 直樹, 坂井田 功, 寺井 崇二

    肝臓   58 ( Suppl.1 )   A448 - A448   2017.4

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  • 術後再建腸管例に対するERCP関連手技における偶発症の現状と対策

    五十嵐 聡, 林 和直, 水野 研一, 本田 穣, 橋本 哲, 横山 純二, 佐藤 祐一, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   59 ( Suppl.1 )   1035 - 1035   2017.4

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  • 当科における術後再建腸管の胆管結石症に対する内視鏡治療の検討

    林 和直, 五十嵐 聡, 水野 研一, 本田 穣, 橋本 哲, 横山 純二, 佐藤 祐一, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   59 ( Suppl.1 )   1036 - 1036   2017.4

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  • Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia Reviewed

    N. Nakajima, H. Sato, K. Takahashi, G. Hasegawa, K. Mizuno, S. Hashimoto, Y. Sato, S. Terai

    NEUROGASTROENTEROLOGY AND MOTILITY   29 ( 3 )   2017.3

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    DOI: 10.1111/nmo.12968

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  • Drug-eluting beads in hepatocellular carcinoma Reviewed

    Hiroyuki Abe, Kenya Kamimura, Shuji Terai

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   10 ( 3 )   337 - 338   2017.3

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  • Re-evaluation of phenotypic expression in differentiated-type early adenocarcinoma of the stomach Reviewed

    Masato Hayakawa, Ken Nishikura, Yoichi Ajioka, Yutaka Aoyagi, Shuji Terai

    PATHOLOGY INTERNATIONAL   67 ( 3 )   131 - 140   2017.3

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    DOI: 10.1111/pin.12506

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  • 当科におけるCrohn病に合併した胆石症の検討

    林 和直, 五十嵐 聡, 水野 研一, 本田 穣, 橋本 哲, 横山 純二, 佐藤 祐一, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増総会 )   A335 - A335   2017.3

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  • 他臓器癌合併IPMNの臨床像

    五十嵐 聡, 林 和直, 水野 研一, 本田 穣, 橋本 哲, 横山 純二, 佐藤 祐一, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増総会 )   A372 - A372   2017.3

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  • 膵癌非切除例における骨格筋量と体脂肪組成の評価による予後解析

    中野 応央樹, 川合 弘一, 小林 隆昌, 五十嵐 聡, 林 和直, 佐藤 祐一, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増総会 )   A271 - A271   2017.3

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  • 自己免疫性肝疾患のパラダイムシフト 原発性胆汁性胆管炎におけるMucosal-associated invariant T細胞の検討

    薛 徹, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増総会 )   A135 - A135   2017.3

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  • Predictive factors of the pharmacological action of tolvaptan in patients with liver cirrhosis: a post hoc analysis Reviewed

    Isao Sakaida, Shuji Terai, Koji Nakajima, Yoshiyuki Shibasaki, Sayaka Tachikawa, Hidetsugu Tsubouchi

    JOURNAL OF GASTROENTEROLOGY   52 ( 2 )   229 - 236   2017.2

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    DOI: 10.1007/s00535-016-1233-x

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  • Lipoprotein-X in cholestatic patients causes xanthomas and promotes foam cell formation in human macrophages Reviewed

    Luka Suzuki, Satoshi Hirayama, Mariko Fukui, Makoto Sasaki, Sadayuki Hiroi, Makoto Ayaori, Shuji Terai, Minoru Tozuka, Hirotaka Watada, Takashi Miida

    JOURNAL OF CLINICAL LIPIDOLOGY   11 ( 1 )   110 - 118   2017.2

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  • Phase 1 Clinical Study of siRNA Targeting Carbohydrate Sulphotransferase 15 in Crohn's Disease Patients with Active Mucosal Lesions Reviewed

    Kenji Suzuki, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Yukinori Sameshima, Tsuneo Fukushima, Kazuyuki Sugahara, Raja Atreya, Markus F. Neurath, Kenichi Watanabe, Hiroyuki Yoneyama, Hitoshi Asakura

    JOURNAL OF CROHNS & COLITIS   11 ( 2 )   221 - 228   2017.2

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    DOI: 10.1093/ecco-jcc/jjw143

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  • A novel technique for biliary biopsy using the sheath of a plastic stent and a non-return valve Reviewed

    Shinichi Morita, Tsutomu Kanefuji, Takahiro Hoshi, Masaaki Kobayashi, Takeshi Suda, Takeshi Mizusawa, Shuji Terai

    ENDOSCOPY   49 ( S 01 )   E9 - E10   2017.2

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  • Loss of peristalsis of the esophagus due to diffuse esophageal leiomyomatosis Reviewed

    Kazuya Takahashi, Yui Ishii, Kazunao Hayashi, Satoshi Ikarashi, Hirokazu Kawai, Yuichi Sato, Shuji Terai

    ENDOSCOPY   49 ( S 01 )   E95 - E96   2017.2

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  • lStatus of and candidates for cell therapy in liver cirrhosis: overcoming the "point of no return'' in advanced liver cirrhosis Reviewed

    Shuji Terai, Atsunori Tsuchiya

    JOURNAL OF GASTROENTEROLOGY   52 ( 2 )   129 - 140   2017.2

  • Early Detection of Hepatocellular Carcinoma Recurrence Using the Highly Sensitive Fucosylated Fraction of Alpha-Fetoprotein Reviewed

    Toru Setsu, Atsunori Tsuchiya, Takayuki Watanabe, Takuro Nagoya, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

    Case Reports in Gastroenterology   11 ( 1 )   142 - 147   2017.1

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    DOI: 10.1159/000462969

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  • Immunohistochemical differentiation of eosinophilic esophageal myositis from eosinophilic esophagitis Reviewed

    Hiroki Sato, Nao Nakajima, Go Hasegawa, Yuzo Kawata, Yuichi Sato, Kenji Suzuki, Terasu Honma, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 ( 1 )   106 - 113   2017.1

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  • Training sample selection based on self-training for liver cirrhosis classification using ultrasound images Reviewed

    Yusuke Fujita, Yoshihiro Mitani, Yoshihiko Hamamoto, Makoto Segawa, Shuji Terai, Isao Sakaida

    THIRTEENTH INTERNATIONAL CONFERENCE ON QUALITY CONTROL BY ARTIFICIAL VISION 2017   10338   103380J   2017

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    DOI: 10.1117/12.2264076

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  • Two cases of cholangiocellular carcinoma complicated with Trousseau’s syndrome

    Shinagawa, Y., Kamimura, K., Sakai, N., Kumaki, D., Ogawa, K., Azumi, R., Tominaga, K., Sakamaki, A., Ikarashi, S., Hayashi, K., Yamamoto, T., Mizuno, K., Yamagiwa, S., Terai, S.

    Kanzo/Acta Hepatologica Japonica   58 ( 9 )   2017

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    DOI: 10.2957/kanzo.58.528

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  • Invasive Liver Abscess Syndrome Caused by Klebsiella pneumoniae Reviewed

    Toru Setsu, Atsunori Tsuchiya, Satoshi Yamagiwa, Shuji Terai

    INTERNAL MEDICINE   56 ( 22 )   3121 - 3122   2017

  • Increase of Soluble Programmed Cell Death Ligand 1 in Patients with Chronic Hepatitis C Reviewed

    Satoshi Yamagiwa, Toru Ishikawa, Nobuo Waguri, Soichi Sugitani, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Shuji Terai

    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES   14 ( 5 )   403 - 411   2017

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    DOI: 10.7150/ijms.18784

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  • Prognostic Impact of Indocyanine Green Plasma Disappearance Rate in Hepatocellular Carcinoma Patients after Radiofrequency Ablation: A Prognostic Nomogram Study Reviewed

    Motoi Azumi, Takeshi Suda, Shuji Terai, Kouhei Akazawa

    INTERNAL MEDICINE   56 ( 9 )   1001 - 1007   2017

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    DOI: 10.2169/internalmedicine.56.7278

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  • Possible involvement of mucosal-associated invariant T cells in the progression of inflammatory bowel diseases Reviewed

    Kentaro Tominaga, Satoshi Yamagiwa, Toru Setsu, Naruhiro Kimura, Hiroki Honda, Hiroteru Kamimura, Yutaka Honda, Masaaki Takamura, Junji Yokoyama, Kenji Suzuki, Toshifumi Wakai, Shuji Terai

    BIOMEDICAL RESEARCH-TOKYO   38 ( 2 )   111 - 121   2017

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    DOI: 10.2220/biomedres.38.111

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  • A Mesenteric Desmoid Tumor with Rapid Progression Reviewed

    Kazunao Hayashi, Masaaki Takamura, Hisashi Yokoyama, Yuichi Sato, Satoshi Yamagiwa, Hitoshi Nogami, Toshifumi Wakai, Go Hasegawa, Shuji Terai

    INTERNAL MEDICINE   56 ( 5 )   505 - 508   2017

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    DOI: 10.2169/internalmedicine.56.7320

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  • Efficacy and safety of telaprevir- and simeprevir-based triple therapies for older patients with chronic hepatitis C Reviewed

    Satoshi Yamagiwa, Toru Ishikawa, Nobuo Waguri, Soichi Sugitani, Hiroto Wakabayashi, Shogo Ohkoshi, Takashi Tsukishiro, Toru Takahashi, Toshiaki Watanabe, Shuji Terai

    World Journal of Hepatology   9 ( 5 )   252 - 262   2017

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    DOI: 10.4254/wjh.v9.i5.252

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  • Clinical trials using mesenchymal stem cells in liver diseases and inflammatory bowel diseases. Reviewed International journal

    Tsuchiya A, Kojima Y, Ikarashi S, Seino S, Watanabe Y, Kawata Y, Terai S

    Inflammation and regeneration   37   16 - 16   2017

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    Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functions, suggesting their potential applications in a variety of diseases, including liver disease and inflammatory bowel disease. MSCs help prepare the microenvironment, in response to inflammatory cytokines, by producing immunoregulatory factors that modulate the progression of inflammation by affecting dendritic cells, B cells, T cells, and macrophages. MSCs also produce a large amount of cytokines, chemokines, and growth factors, including exosomes that stimulate angiogenesis, prevent apoptosis, block oxidation reactions, promote remodeling of the extracellular matrix, and induce differentiation of tissue stem cells. According to ClinicalTrials.gov, more than 680 clinical trials using MSCs are registered for cell therapy of many fields including liver diseases (more than 40 trials) and inflammatory bowel diseases (more than 20 trials). In this report, we introduce background and clinical studies of MSCs in liver disease and inflammatory bowel diseases.

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  • Tumor markers for early diagnosis for brain metastasis of hepatocellular carcinoma: A case series and literature review for effective loco-regional treatment Reviewed

    Kenya Kamimura, Yuji Kobayashi, Yoshifumi Takahashi, Hiroyuki Abe, Daisuke Kumaki, Takeshi Yokoo, Hiroteru Kamimura, Norihiro Sakai, Akira Sakamaki, Satoshi Abe, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    CANCER BIOLOGY & THERAPY   18 ( 2 )   79 - 84   2017

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  • An Unusual Case of an Extremely Large alpha-Fetoprotein-Producing Tumor Reviewed

    Kazuya Takahashi, Atsunori Tsuchiya, Shuji Terai

    GASTROENTEROLOGY   151 ( 6 )   1077 - 1080   2016.12

  • Myofibroblast distribution is associated with invasive growth types of colorectal cancer Reviewed

    Masafumi Takatsuna, Satoko Morohashi, Tadashi Yoshizawa, Hideaki Hirai, Toshihiro Haga, Rie Ota, Kensuke Saito, Yunyan Wu, Hiroko Seino, Yutaka Aoyagi, Shuji Terai, Hiroshi Kijima

    ONCOLOGY REPORTS   36 ( 6 )   3154 - 3160   2016.12

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  • Transhepatic arterial chemotherapy using a combination of miriplatin and CDDP powder in patients with hepatocellular carcinoma Reviewed

    Kenya Kamimura, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Toru Ishikawa, Takeshi Suda, Satoshi Yamagiwa, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   361 - 361   2016.11

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  • [Series: Diagnosis at a Glance]. Reviewed

    Kobayashi T, Tsuchiya A, Kuraoka N, Yamamoto T, Honda Y, Yokoyama J, Kawai H, Yamagiwa S, Suda T, Terai S

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   105 ( 11 )   2263 - 2267   2016.11

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  • Vonoprazan 20 mg <i>vs</i> lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers. Reviewed International journal

    Takahashi K, Sato Y, Kohisa J, Watanabe J, Sato H, Mizuno K, Hashimoto S, Terai S

    World journal of gastrointestinal endoscopy   8 ( 19 )   716 - 722   2016.11

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    AIM: To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection (ESD). METHODS: Data were obtained from a total of 26 patients. Fourteen patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole group. Patients were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after ESD. Endoscopic images just after ESD, on day 8, and on day 28 were used for the evaluation of the shrinking rate of ESD ulcers. The shrinking rates and the incidence of delayed bleeding were compared between the 2 groups. RESULTS: The shrinking rates of ESD ulcers on day 8 [vonoprazan group: 61.8% (range: 24.0%-91.1%), lansoprazole group: 71.3% (range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3% (range: 76.2%-100%), lansoprazole group: 97.2% (range: 81.1%-99.8%)] were not statistically different between the 2 groups. On day 28, most of the ulcers in both groups healed to more than 90%, whereas 3 of 14 (21.4%) in the vonoprazan group and 1 of 12 (8.3%) in the lansoprazole group had delayed ulcer healing, which was not statistically different (P = 0.356). The frequency of delayed bleeding was 0 in the both groups. Taken together, there were no significant differences between the two drug groups. CONCLUSION: Our study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective.

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  • Case of severe alcoholic hepatitis treated with granulocytapheresis Reviewed

    Yukari Watanabe, Kenya Kamimura, Tomohiro Iwasaki, Hiroyuki Abe, Shunsaku Takahashi, Ken-ichi Mizuno, Manabu Takeuchi, Atsushi Eino, Ichiei Narita, Shuji Terai

    WORLD JOURNAL OF CLINICAL CASES   4 ( 11 )   369 - 374   2016.11

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    DOI: 10.12998/wjcc.v4.i11.369

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  • Significance of hepatic progenitor cell marker-positive hepatocellular carcinoma and its possible prediction by AFP-L3 Reviewed

    Atsunori Tsuchiya, Yuichi Kojima, Satoshi Seino, Yusuke Watanabe, Kenya Kamimura, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    HEPATOLOGY   64   669A - 670A   2016.10

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  • Platinum-based transhepatic arterial chemotherapy using a combination of miriplatin and CDDP powder in patients with hepatocellular carcinoma Reviewed

    Kohei Ogawa, Kenya Kamimura, Takeshi Suda, Takeshi Yokoo, Akira Sakamaki, Satoshi Abe, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Toru Ishikawa, Satoshi Yamagiwa, Shuji Terai

    HEPATOLOGY   64   652A - 652A   2016.10

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  • Biological significance of a disintegrin and metalloproteinase 21 expression in hepatocellular carcinoma Reviewed

    Masaaki Takamura, Hiroki Honda, Satoshi Yamagiwa, Naruhiro Kimura, Toru Setsu, Kentaro Tominaga, Hiroteru Kamimura, Takuya Genda, Yasunobu Matsuda, Toshifumi Wakai, Shuji Terai

    HEPATOLOGY   64   639A - 639A   2016.10

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  • Liver-targeted hydrodynamic gene therapy: Recent advances in the technique Reviewed

    Takeshi Yokoo, Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Tsutomu Kanefuji, Kohei Ogawa, Ryo Goto, Masafumi Oda, Takeshi Suda, Shuji Terai, Masafumi Oda

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 40 )   8862 - 8868   2016.10

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  • Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer Reviewed

    Masafumi Takatsuna, Satoko Morohashi, Tadashi Yoshizawa, Hideaki Hirai, Toshihiro Haga, Rie Ota, Yunyan Wu, Hajime Morohashi, Kenichi Hakamada, Shuji Terai, Hiroshi Kijima

    ONCOLOGY REPORTS   36 ( 3 )   1251 - 1257   2016.9

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  • Assessments of histologic changes after peroral endoscopic myotomy. Reviewed

    Sato H, Sagara S, Suzuki K, Terai S, Yahagi N

    Gastrointestinal endoscopy   84 ( 2 )   377 - 378   2016.8

  • A novel training model composed of nonbiological materials for endoscopic submucosal dissection Reviewed

    Ken-ichi Mizuno, Hiroki Sato, Satoru Hashimoto, Yuichi Sato, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   84 ( 2 )   373 - 374   2016.8

  • Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery Reviewed

    Yuji Kobayashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Yokoo, Kohei Ogawa, Yoko Shinagawa-Kobayashi, Ryo Goto, Ryosuke Inoue, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   5 ( 8 )   e359   2016.8

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  • Management of gastric and duodenal neuroendocrine tumors Reviewed

    Yuichi Sato, Satoru Hashimoto, Ken-ichi Mizuno, Manabu Takeuchi, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   22 ( 30 )   6817 - 6828   2016.8

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  • Novel ex-vivo training model for peroral endoscopic myotomy using hydrogel Reviewed

    Hiroki Sato, Ken-ichi Mizuno, Shuji Terai

    DIGESTIVE ENDOSCOPY   28 ( 5 )   620 - 620   2016.7

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  • Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis Reviewed

    Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Shuji Mizumoto, Kazuyuki Sugahara, Raja Atreya, Markus F. Neurath, Kenichi Watanabe, Taishi Hashiguchi, Hiroyuki Yoneyama, Hitoshi Asakura

    PLOS ONE   11 ( 7 )   e0158967   2016.7

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  • Therapeutic or spontaneous Helicobacter pylori eradication can obscure magnifying narrow-band imaging of gastric tumors. Reviewed

    Kobayashi M, Hashimoto S, Mizuno K, Takeuchi M, Sato Y, Watanabe G, Ajioka Y, Azumi M, Akazawa K, Terai S

    Endoscopy international open   4 ( 6 )   E665 - 72   2016.6

  • Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib Reviewed

    Naoki Yamamoto, Takahiro Yamasaki, Taro Takami, Koichi Uchida, Koichi Fujisawa, Toshihiko Matsumoto, Issei Saeki, Shuji Terai, Isao Sakaida

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   58 ( 3 )   202 - 209   2016.5

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    DOI: 10.3164/jcbn.15-127

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  • Effective prevention of hand-foot syndrome by the consumption of dried bonito broth Reviewed

    Kenya Kamimura, Yoko Shinagawa, Kohei Ogawa, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Hiroteru Kamimura, Hirokazu Kawai, Takeshi Suda, Satoshi Yamagiwa, Hiroshi Baba, Shuji Terai

    Japanese Journal of Cancer and Chemotherapy   43 ( 4 )   463 - 465   2016.4

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  • 当院における悪性胃十二指腸狭窄に対する内視鏡的ステント留置術の有用性の検討

    林 和直, 山本 幹, 水野 研一, 本田 穣, 橋本 哲, 横山 純二, 竹内 学, 佐藤 祐一, 寺井 崇二

    Gastroenterological Endoscopy   58 ( Suppl.1 )   790 - 790   2016.4

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  • Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4 Reviewed International journal

    Fujisawa Koichi, Terai Shuji, Takami Taro, Yamamoto Naoki, Yamasaki Takahiro, Matsumoto Toshihiko, Yamaguch Kazuhito, Owada Yuji, Nishina Hiroshi, Takafumi Noma, Sakaida Isao

    Journal of Experimental & Clinical Cancer Research   Vol.35 ( No.1 )   48 - 48   2016.3

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    Background: Adenylate kinase is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. Anisoform of this enzyme, adenylate kinase 4 (AK4), is localized in the mitochondrial matrix and is believed to beinvolved in stress, drug resistance, malignant transformation in cancer, and ATP regulation. However, the molecularbasis for the AK4 functions remained to be determined.Methods: HeLa cells were transiently transfected with an AK4 small interfering RNA (siRNA), an AK4 short hairpinRNA (shRNA) plasmid, a control shRNA plasmid, an AK4 expression vector, and a control expression vector toexamine the effect of the AK4 expression on cell proliferation, sensitivity to anti-cancer drug, metabolome, geneexpression, and mitochondrial activity.Results: AK4 knockdown cells treated with short hairpin RNA increased ATP production and showed greatersensitivity to hypoxia and anti-cancer drug, cis-diamminedichloro-platinum (II) (CDDP). Subcutaneous grafting AK4knockdown cells into nude mice revealed that the grafted cells exhibited both slower proliferation and reduced thetumor sizes in response to CDDP. AK4 knockdown cell showed a increased oxygen consumption rate with FCCPtreatment, while AK4 overexpression lowered it. Metabolome analysis showed the increased levels of thetricarboxylic acid cycle intermediates, fumarate and malate in AK4 knockdown cells, while AK4 overexpressionlowered them. Electron microscopy detected the increased mitochondrial numbers in AK4 knockdown cells.Microarray analysis detected the increased gene expression of two key enzymes in TCA cycle, succinatedehydrogenase A (SDHA) and oxoglutarate dehydrogenease L (OGDHL), which are components of SDH complexand OGDH complex, supporting the metabolomic results.Conclusions: We found that AK4 was involved in hypoxia tolerance, resistance to anti-tumor drug, and theregulation of mitochondrial activity. These findings provide a new potential target for efficient anticancer therapiesby controlling AK4 expression.

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  • Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4. Reviewed International journal

    Fujisawa K, Terai S, Takami T, Yamamoto N, Yamasaki T, Matsumoto T, Yamaguchi K, Owada Y, Nishina H, Noma T, Sakaida I

    Journal of experimental & clinical cancer research : CR   35   48 - 48   2016.3

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    BACKGROUND: Adenylate kinase is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. An isoform of this enzyme, adenylate kinase 4 (AK4), is localized in the mitochondrial matrix and is believed to be involved in stress, drug resistance, malignant transformation in cancer, and ATP regulation. However, the molecular basis for the AK4 functions remained to be determined. METHODS: HeLa cells were transiently transfected with an AK4 small interfering RNA (siRNA), an AK4 short hairpin RNA (shRNA) plasmid, a control shRNA plasmid, an AK4 expression vector, and a control expression vector to examine the effect of the AK4 expression on cell proliferation, sensitivity to anti-cancer drug, metabolome, gene expression, and mitochondrial activity. RESULTS: AK4 knockdown cells treated with short hairpin RNA increased ATP production and showed greater sensitivity to hypoxia and anti-cancer drug, cis-diamminedichloro-platinum (II) (CDDP). Subcutaneous grafting AK4 knockdown cells into nude mice revealed that the grafted cells exhibited both slower proliferation and reduced the tumor sizes in response to CDDP. AK4 knockdown cell showed a increased oxygen consumption rate with FCCP treatment, while AK4 overexpression lowered it. Metabolome analysis showed the increased levels of the tricarboxylic acid cycle intermediates, fumarate and malate in AK4 knockdown cells, while AK4 overexpression lowered them. Electron microscopy detected the increased mitochondrial numbers in AK4 knockdown cells. Microarray analysis detected the increased gene expression of two key enzymes in TCA cycle, succinate dehydrogenase A (SDHA) and oxoglutarate dehydrogenease L (OGDHL), which are components of SDH complex and OGDH complex, supporting the metabolomic results. CONCLUSIONS: We found that AK4 was involved in hypoxia tolerance, resistance to anti-tumor drug, and the regulation of mitochondrial activity. These findings provide a new potential target for efficient anticancer therapies by controlling AK4 expression.

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  • Advanced diagnostic endoscopy for gastric cancers discovered after H. Pylori eradication Reviewed

    Masaaki Kobayashi, Takahiro Hoshi, Shin-Ichi Morita, Tsutomu Kanefuji, Takeshi Suda, Ken-Ichi Mizuno, Satoru Hashimoto, Manabu Takeuchi, Yuichi Sato, Shuji Terai

    Journal of Japanese Society of Gastroenterology   113 ( 2 )   235 - 244   2016.2

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    DOI: 10.11405/nisshoshi.113.235

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  • Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB Reviewed

    Yosuke Motai, Masahiko Takahashi, Takayuki Takachi, Masaya Higuchi, Toshifumi Hara, Mariko Mizuguchi, Yutaka Aoyagi, Shuji Terai, Yuetsu Tanaka, Masahiro Fujii

    VIRUS GENES   52 ( 1 )   4 - 13   2016.2

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  • Circadian variations in the liver metabolites of medaka (Oryzias latipes) Reviewed

    Koichi Fujisawa, Taro Takami, Yoshitaka Kimoto, Toshihiko Matsumoto, Naoki Yamamoto, Shuji Terai, Isao Sakaida

    SCIENTIFIC REPORTS   6   20916   2016.2

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  • Percutaneous transhepatic obliteration for hepatic encephalopathy accompanied with chronic renal failure in a super-elderly patient: A case report Reviewed

    Yusuke Watanabe, Toru Ishikawa, Satoshi Abe, Ryousuke Inoue, Tomoyuki Sugano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida, Takeo Nemoto, Keiko Takeda, Shuji Terai

    Acta Hepatologica Japonica   56 ( 12 )   668 - 674   2016.1

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    DOI: 10.2957/kanzo.56.668

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  • Liver regeneration therapy using autologous bone marrow-derived cells for cirrhotic patients Reviewed

    Taro Takami, Isao Sakaida, Shuji Terai

    Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects   25 - 34   2016.1

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    DOI: 10.1007/978-4-431-55666-4_3

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  • Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model Reviewed

    Hiroyuki Abe, Kenya Kamimura, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Riuko Ohashi, Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY-NUCLEIC ACIDS   5   e276   2016.1

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  • Training ROI selection based on MILBoost for liver cirrhosis classification using ultrasound images Reviewed

    Fujita, Y., Mitani, Y., Hamamoto, Y., Segawa, M., Terai, S., Sakaida, I.

    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)   9799   451 - 459   2016

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    DOI: 10.1007/978-3-319-42007-3_39

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  • Improvement of Pancreatic Tumor-induced NAFLD with Pancrelipase Reviewed

    Naosuke Kuraoka, Atsunori Tsuchiya, Takeshi Suda, Shuji Terai

    INTERNAL MEDICINE   55 ( 1 )   89 - 90   2016

  • Three Times Repeated Portal Venous Gas after Meals Reviewed

    Takamasa Kobayashi, Atsunori Tsuchiya, Takeshi Suda, Shuji Terai

    INTERNAL MEDICINE   55 ( 7 )   843 - 845   2016

  • Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy Reviewed

    Kanae Hirose, Tsutomu Kanefuji, Takeshi Suda, Souichi Sugitani, Keisuke Nagasaki, Tomoyuki Kubota, Masato Igarashi, Shuji Terai

    GASTROENTEROLOGY RESEARCH AND PRACTICE   2016   6343656   2016

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  • Endoscopic Removal of Ingested Dentures and Dental Instruments: A Retrospective Analysis Reviewed

    Ken-ichi Mizuno, Kazuya Takahashi, Kentaro Tominaga, Yuki Nishigaki, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Takashi Yamamoto, Yutaka Honda, Satoru Hashimoto, Kenya Kamimura, Manabu Takeuchi, Junji Yokoyama, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    GASTROENTEROLOGY RESEARCH AND PRACTICE   2016   3537147   2016

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  • Stomach Dysfunction Is a Potential Risk Factor for Wernicke's Encephalopathy Reviewed

    Oki Nakano, Atsunori Tsuchiya, Satoshi Yamagiwa, Shuji Terai

    INTERNAL MEDICINE   55 ( 24 )   3679 - 3680   2016

  • The Combination Therapy of Dissolution Using Carbonated Liquid and Endoscopic Procedure for Bezoars: Pragmatical and Clinical Review Reviewed

    Kohei Ogawa, Kenya Kamimura, Ken-ichi Mizuno, Yoko Shinagawa, Yuji Kobayashi, Hiroyuki Abe, Yukari Watanabe, Shunsaku Takahashi, Kazunao Hayashi, Junji Yokoyama, Manabu Takeuchi, Masaaki Kobayashi, Satoshi Yamagiwa, Yuichi Sato, Shuji Terai

    GASTROENTEROLOGY RESEARCH AND PRACTICE   2016   7456242   2016

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  • A CASE OF BENIGN BILIARY STRICTURE AFTER CHOLEDOCHOJEJUNOSTOMY THAT WAS SUCCESSFULLY MANAGED USING A FULLY COVERED SELF-EXPANDING METALLIC STENT

    MORITA Shinichi, SETSU Toru, HOSHI Takahiro, KANEFUJI Tsutomu, KOBAYASHI Masaaki, SUDA Takeshi, TERAI Shuji

    Gastroenterological Endoscopy   58 ( 11 )   2279 - 2286   2016

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    <p>A 70-year-old woman was hospitalized due to acute cholangitis one year after resection of the extrahepatic bile duct and choledochojejunostomy for malfusion of the pancreatobiliary ducts. She underwent percutaneous transhepatic biliary drainage (PTBD), and after her general condition improved, we tried to introduce a guidewire for internal drainage but were unable to do so because of severe anastomotic stenosis. Using a bronchoscope as a slim endoscope, we inserted the bronchoscope via the PTBD route and visualized a punctiform scar. Subsequently, we were able to pass the guidewire and a drainage tube through the stricture, followed by placement of a fully covered self-expanding metallic stent. The stricture became dilated and we removed the stent four months later. Thereafter, we injected contrast medium into the bile ducts via the PTBD route and confirmed dilatation of the stricture, allowing removal of the PTBD tube. This case illustrates that a fully covered self-expanding metallic stent can be used to dilate an area of biliary stricture continuously and can be removed later. This approach is effective and feasible for management of benign biliary strictures.</p>

    DOI: 10.11280/gee.58.2279

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  • Enhanced survival of mice infused with bone marrow-derived as compared with adipose-derived mesenchymal stem cells Reviewed

    Shogo Shiratsuki, Shuji Terai, Yasuhiko Murata, Taro Takami, Naoki Yamamoto, Koichi Fujisawa, Guzel Burganova, Luiz Fernando Quintanilha, Isao Sakaida

    HEPATOLOGY RESEARCH   45 ( 13 )   1353 - 1359   2015.12

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  • First case of bacteremia caused by Helicobacter cinaedi in a patient with liver cirrhosis: a case report and literature review Reviewed

    Kenya Kamimura, Daisuke Kumaki, Masashi Arita, Yuji Kobayashi, Ken-ichi Mizuno, Fumiko Kusama, Megumi Kobayashi, Hiroyuki Abe, Yoshifumi Takahashi, Kohei Ogawa, Yoko Shinagawa, Manabu Takeuchi, Yuichi Sato, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    Clinical Journal of Gastroenterology   8 ( 5 )   306 - 317   2015.10

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  • Evaluation of esophageal motility after endoscopic submucosal dissection for superficial esophageal cancer Reviewed

    Kazuya Takahashi, Manabu Takeuchi, Yuichi Sato, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Masaaki Kobayashi, Shuji Terai

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   27 ( 10 )   1187 - 1192   2015.10

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  • Histological and Transcriptomic Analysis of Adult Japanese Medaka Sampled Onboard the International Space Station Reviewed

    Yasuhiko Murata, Takako Yasuda, Tomomi Watanabe-Asaka, Shoji Oda, Akiko Mantoku, Kazuhiro Takeyama, Masahiro Chatani, Akira Kudo, Satoko Uchida, Hiromi Suzuki, Fumiaki Tanigaki, Masaki Shirakawa, Koichi Fujisawa, Yoshihiko Hamamoto, Shuji Terai, Hiroshi Mitani

    PLOS ONE   10 ( 10 )   e0138799   2015.10

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  • Endoscopic surveillance of gastric cancers after Helicobacter pylori eradication Reviewed

    Masaaki Kobayashi, Yuichi Sato, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 37 )   10553 - 10562   2015.10

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  • Possible involvement of activating follicular helper T cells in autoimmune hepatitis Reviewed

    Kimura Naruhiro, Yamagiwa Satoshi, Honda Hiroki, Setsu Toru, Tominaga Kentaro, Kamimura Hiroteru, Takamura Masaaki, Terai Shuji

    HEPATOLOGY   62   369A - 369A   2015.10

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  • Site-specific impact of a regional hydrodynamic injection: Computed tomography study during hydrodynamic injection targeting the swine liver Reviewed

    Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Kenya Kamimura, Dexi Liu, Shuji Terai

    Pharmaceutics   7 ( 3 )   334 - 343   2015.9

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    DOI: 10.3390/pharmaceutics7030334

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  • Nutcracker and jackhammer esophagus treatment: a three-case survey, including two novel cases of eosinophilic infiltration into the muscularis propria Reviewed

    Hiroki Sato, Manabu Takeuchi, Kazuya Takahashi, Yuichi Sato, Satoru Hashimoto, Kenichi Mizuno, Kenji Suzuki, Masaaki Kobayashi, Terasu Honma, Haruhiro Inoue, Shuji Terai

    ENDOSCOPY   47 ( 9 )   855 - 857   2015.9

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  • Image-guided hydrodynamic gene delivery: Current status and future directions Reviewed

    Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Yuji Kobayashi, Kohei Ogawa, Yoko Shinagawa, Ryosuke Inoue, Shuji Terai

    Pharmaceutics   7 ( 3 )   213 - 223   2015.8

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    DOI: 10.3390/pharmaceutics7030213

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  • Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging (vol 10, e0129950, 2015) Reviewed

    Koichi Fujisawa, Shuji Terai, Toshihiko Matsumoto, Taro Takami, Naoki Yamamoto, Hiroshi Nishina, Makoto Furutani-Seiki, Isao Sakaida

    PLOS ONE   10 ( 8 )   e0137156   2015.8

  • 臨床応用の現状 非代償性肝硬変症に対する再生療法

    寺井 崇二, 高見 太郎, 坂井田 功

    メディカル朝日   44 ( 8 )   36 - 37   2015.8

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  • 抗結核薬による昏睡型急性肝不全の一例

    松田 崇史, 石川 剛, 岩本 拓也, 佐伯 一成, 日高 勲, 高見 太郎, 寺井 崇二, 坂井田 功

    肝臓   56 ( 7 )   387 - 388   2015.7

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  • Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging Reviewed

    Koichi Fujisawa, Shuji Terai, Toshihiko Matsumoto, Taro Takami, Naoki Yamamoto, Hiroshi Nishina, Makoto Furutani-Seiki, Isao Sakaida

    PLOS ONE   10 ( 6 )   e0129950   2015.6

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  • Autologous bone marrow cell infusion therapy for hepatitis C virus infected liver cirrhosis. Reviewed

    Aibe Y, Takami T, Terai S, Sakaida I

    Nihon rinsho. Japanese journal of clinical medicine   73 Suppl 5   499 - 503   2015.6

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  • 【再生医療-新たな医療を求めて-】再生医療の臨床研究・治験 C型肝炎ウイルス起因肝硬変に対する自己骨髄細胞投与療法

    相部 祐希, 高見 太郎, 寺井 崇二, 坂井田 功

    日本臨床   73 ( 増刊5 再生医療 )   499 - 503   2015.6

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  • 特発性血小板減少性紫斑病を合併した原発性胆汁性肝硬変 自己免疫性肝炎オーバーラップ症候群に部分的脾動脈塞栓術を施行した1例

    仁志 麻衣子, 石川 剛, 相部 祐希, 白築 祥吾, 松田 崇史, 岩本 拓也, 高見 太郎, 寺井 崇二, 坂井田 功

    日本門脈圧亢進症学会雑誌   21 ( 2 )   122 - 127   2015.6

  • Rheological modification of hydrodynamic gene delivery

    Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Akiomi Ushida, Tomiichi Hasegawa, Kenya Kamimura, Dexi Liu, Shuji Terai

    Proceedings of The 18th Annual Meeting of the American Society of Gene and Cell Therapy   ( 350594 )   140 - 141   2015.5

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  • 早期胃癌に対するESD後に発生した遅発性穿孔の検討 Reviewed

    荒生 祥尚, 小林 正明, 橋本 哲, 水野 研一, 竹内 学, 本田 博樹, 影向 一美, 高村 昌昭, 佐藤 祐一, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   31 ( 1 )   27 - 32   2015.5

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  • Effective Prevention of Liver Fibrosis by Liver-Targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in Rat Liver Fibrosis Model Reviewed

    Abe Hiroyuki, Kamimura Kenya, Kobayashi Yuji, Ohtsuka Masato, Miura Hiromi, Ohashi Riuko, Yokoo Takeshi, Kanefuji Tsutomu, Suda Takeshi, Tsuchida Masanori, Aoyagi Yutaka, Zhang Guisheng, Liu Dexi, Terai Shuji

    MOLECULAR THERAPY   23   S234   2015.5

  • A New Therapeutic Assessment Score for Advanced Hepatocellular Carcinoma Patients Receiving Hepatic Arterial Infusion Chemotherapy Reviewed

    Issei Saeki, Takahiro Yamasaki, Norikazu Tanabe, Takuya Iwamoto, Toshihiko Matsumoto, Yohei Urata, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Naoki Yamamoto, Koichi Uchida, Shuji Terai, Isao Sakaida

    PLOS ONE   10 ( 5 )   e0126649   2015.5

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  • Advances in understanding and treating liver diseases during pregnancy: A review Reviewed

    Kenya Kamimura, Hiroyuki Abe, Hirokazu Kawai, Hiroteru Kamimura, Yuji Kobayashi, Minoru Nomoto, Yutaka Aoyagi, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 17 )   5183 - 5190   2015.5

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  • Effect of Fibrotic Tissue on Liver-Targeted Hydrodynamic Gene Delivery Reviewed

    Kobayashi Yuji, Kamimura Kenya, Abe Hiroyuki, Ohtsuka Masato, Miura Hiromi, Yokoo Takeshi, Kanefuji Tsutomu, Suda Takeshi, Zhang Guisheng, Tsuchida Masanori, Aoyagi Yutaka, Liu Dexi, Terai Shuji

    MOLECULAR THERAPY   23   S141   2015.5

  • Factors predicting aggressiveness of non-hypervascular hepatic nodules detected on hepatobiliary phase of gadolinium ethoxybenzyl diethylene-triamine-pentaacetic-acid magnetic resonance imaging Reviewed

    Tsutomu Kanefuji, Toru Takano, Takeshi Suda, Kouhei Akazawa, Takeshi Yokoo, Hiroteru Kamimura, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Hidefumi Aoyama, Minoru Nomoto, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 15 )   4583 - 4591   2015.4

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    DOI: 10.3748/wjg.v21.i15.4583

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  • 【炎症と線維化】肝線維化に対する骨髄由来細胞を用いた治療戦略

    寺井 崇二, 高見 太郎, 土屋 淳紀, 坂井田 功

    細胞   47 ( 4 )   176 - 179   2015.4

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  • 臨床応用の基盤形成を目指した肝再生研究の新展開 自己骨髄細胞による肝臓再生療法の臨床実施とそのメカニズム解析

    高見 太郎, 寺井 崇二, 坂井田 功

    肝臓   56 ( Suppl.1 )   A146 - A146   2015.4

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  • 定圧炭酸ガス送気システムを用いた大腸内視鏡下腸管内送気圧と検査時の苦痛、最適な内視鏡視野との関連について

    高橋 祥史, 水野 研一, 小林 正明, 高橋 一也, 西垣 祐紀, 林 和直, 山本 幹, 本田 穣, 橋本 哲, 横山 純二, 竹内 学, 佐藤 祐一, 寺井 崇二

    Gastroenterological Endoscopy   57 ( Suppl.1 )   927 - 927   2015.4

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  • 膵漿液性嚢胞腺腫(SCA)の外科切除例の検討

    林 和直, 山本 幹, 塩路 和彦, 小林 正明, 若井 俊文, 寺井 崇二

    Gastroenterological Endoscopy   57 ( Suppl.1 )   985 - 985   2015.4

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  • Modern Immunologyからみた肝病態 原発性胆汁性肝硬変におけるMucosal associated invariant T cellsの検討

    薛 徹, 山際 訓, 寺井 崇二

    肝臓   56 ( Suppl.1 )   A62 - A62   2015.4

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  • C型肝炎の肝線維化経時的評価におけるReal-time Tissue Elastography(RTE)の有用性

    花園 忠相, 日高 勲, 佐伯 一成, 岩本 拓也, 石川 剛, 寺井 崇二, 坂井田 功

    肝臓   56 ( Suppl.1 )   A538 - A538   2015.4

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  • Collagenous gastritis: Review. Reviewed

    Kamimura K, Kobayashi M, Sato Y, Aoyagi Y, Terai S

    World journal of gastrointestinal endoscopy   7 ( 3 )   265 - 273   2015.3

  • 低侵襲肝臓再生療法

    坂井田 功, 寺井 崇二, 高見 太郎

    日本消化器病学会雑誌   112 ( 臨増総会 )   A22 - A22   2015.3

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  • 消化器疾患における線維化の病態と診療 骨髄細胞を用いた線維化と発癌を標的とした肝臓再生療法の開発と展望

    高見 太郎, 寺井 崇二, 坂井田 功

    日本消化器病学会雑誌   112 ( 臨増総会 )   A104 - A104   2015.3

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  • DEB-TACE有効症例の検討 TACE後CT値に注目して

    佐伯 一成, 相部 祐希, 中島 崇雄, 田邉 規和, 白築 祥吾, 花園 忠相, 岩本 拓也, 日高 勲, 石川 剛, 寺井 崇二, 山崎 隆弘, 坂井田 功

    日本消化器病学会雑誌   112 ( 臨増総会 )   A451 - A451   2015.3

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  • 当科における急性肝不全及び薬物性肝障害の現況

    花園 忠相, 日高 勲, 佐伯 一成, 岩本 拓也, 石川 剛, 寺井 崇二, 坂井田 功

    日本消化器病学会雑誌   112 ( 臨増総会 )   A504 - A504   2015.3

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  • Interferon β+ribavirin併用療法によりsustained virological responseが得られたCharcot-Marie-Tooth病合併C型慢性肝炎の一例

    松浦 桂司, 日高 勲, 花園 忠相, 佐伯 一成, 岩本 拓也, 石川 剛, 高見 太郎, 川井 元晴, 寺井 崇二, 神田 隆, 坂井田 功

    山口医学   64 ( 1 )   53 - 57   2015.2

  • 【肥満症診療最前線】肥満に起因する疾患の検査、治療のポイントは? 体重減少の効果を主に 非アルコール性肝疾患(脂肪肝)

    寺井 崇二, 佐伯 一成, 日高 勲, 丸本 芳雄, 橋本 真一, 岡本 健志, 坂井田 功

    Modern Physician   35 ( 2 )   191 - 194   2015.2

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  • 肝細胞癌に対する肝動脈化学塞栓療法施行直後に腫瘍破裂を来した一例

    福井 悠美, 佐伯 一成, 花園 忠相, 田邉 規和, 浦田 洋平, 日高 勲, 寺井 崇二, 坂井田 功

    山口医学   64 ( 1 )   35 - 40   2015.2

  • Delayed perforation after endoscopic submucosal dissection for early gastric cancer

    Arao, Y., Kobayashi, M., Hashimoto, S., Mizuno, K., Takeuchi, M., Honda, H., Yoko, K., Takamura, M., Sato, Y., Terai, S.

    Endoscopic Forum for Digestive Disease   31 ( 1 )   2015

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  • Three cases of Meckel's diverticulum in adult patients diagnosed using transanal balloon enteroscopy

    Azumi, R., Yokoyama, J., Honda, Y., Yamagiwa, S., Terai, S., Komukai, S., Ohashi, Y., Matsuzawa, N., Kobayashi, K., Hashidate, H., Shibuya, H.

    Endoscopic Forum for Digestive Disease   31 ( 1 )   2015

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  • Epiphrenic diverticulum of the esophagus after peroral endoscopic myotomy Reviewed

    Hiroki Sato, Kazuya Takahashi, Manabu Takeuchi, Yuichi Sato, Satoru Hashimoto, Kenichi Mizuno, Shuji Terai

    ENDOSCOPY   47   E509 - E510   2015

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  • Four Cases of Ruptured Duodenal Varices

    SASAKI Ryo, MATSUDA Takashi, AIBE Yuki, NAKASHIMA Takao, SHIRATSUKI Shogo, IWAMOTO Takuya, ISHIKAWA Tsuyoshi, TERAI Shuuji, SAKAIDA Isamu

    Yamaguchi Medical Journal   64 ( 2 )   145 - 152   2015

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    <p>Duodenal varices(DV)are the most common of ectopic varices. Although bleeding from DV is rare, it is difficult to control bleeding and sometimes fatal. We have encountered four clinical cases of ruptured DV. Case 1:A man in his 80s presented with a history of partial gastrectomy with Billroth-II reconstruction and LC due to chronic hepatitis C. We performed single-balloon endoscopy and injected 67% N-butyl-2-cyanoacrylate(NBCA)for DV on the afferent loop with red plug. Case 2:A woman in her 40s with primary biliary cirrhosis complained of tarry stool and anemia. We performed endoscopic injection sclerotherapy(EIS)with 67% NBCA for spurting bleeding point in duodenum. Case 3:A man in his 50s with liver cirrhosis(LC)due to chronic hepatitis B complained of tarry stool. We performed endoscopic variceal ligation(EVL)and balloon-occluded retrograde transvenous obliteration(B-RTO)for DV. Case 4:A man in his 60s with alcoholic LC complained of tarry stool. We performed EIS with 67% NBCA for DV. We added EVL, clipping, and argon plasma coagulation after EIS to control bleeding. To control bleeding was achieved in all cases.</p>

    DOI: 10.2342/ymj.64.145

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  • 【肝胆膵診療のNew Horizon】肝臓疾患 肝硬変 肝性浮腫に対するバソプレシンV2受容体拮抗剤トルバプタンの使用法の提案 肝性浮腫の発生機序から考える

    寺井 崇二, 田邊 規和, 五嶋 敦史, 坂井田 功

    肝胆膵   69 ( 6 )   955 - 960   2014.12

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  • 造影エコーにて評価した回腸NETの1例

    佐伯 一成, 高見 太郎, 寺井 崇二, 坂井田 功

    超音波医学   41 ( 6 )   908 - 908   2014.11

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  • Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease Reviewed

    Takashi Oono, Takahiro Yamasaki, Junichi Zaitsu, Issei Saeki, Takuya Iwamoto, Yumiko Harima, Yoshio Marumoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Makoto Segawa, Koichi Uchida, Shuji Terai, Ichiro Kunitugu, Tsuyoshi Tanabe, Isao Sakaida

    HEPATOLOGY RESEARCH   44 ( 10 )   E54 - E62   2014.10

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    DOI: 10.1111/hepr.12213

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  • Canine mesenchymal stem cells show antioxidant properties against thioacetamide-induced liver injury in vitro and in vivo Reviewed

    Luiz Fernando Quintanilha, Taro Takami, Yoshikazu Hirose, Koichi Fujisawa, Yasuhiko Murata, Naoki Yamamoto, Regina Coeli dos Santos Goldenberg, Shuji Terai, Isao Sakaida

    HEPATOLOGY RESEARCH   44 ( 10 )   E206 - E217   2014.10

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  • Occlusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension Reviewed

    Tsuyoshi Ishikawa, Shogo Shiratsuki, Takashi Matsuda, Takuya Iwamoto, Taro Takami, Koichi Uchida, Shuji Terai, Takahiro Yamasaki, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY   49 ( 9 )   1333 - 1341   2014.9

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    DOI: 10.1007/s00535-013-0893-z

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  • Fatty Acid Binding Protein 7 Regulates Phagocytosis and Cytokine Production in Kupffer Cells during Liver Injury Reviewed

    Hirofumi Miyazaki, Tomoo Sawada, Miwa Kiyohira, Zhiqian Yu, Keiji Nakamura, Yuki Yasumoto, Yoshiteru Kagawa, Majid Ebrahimi, Ariful Islam, Kazem Sharifi, Saki Kawamura, Takanori Kodama, Yui Yamamoto, Yasuhiro Adachi, Nobuko Tokuda, Shuji Terai, Isao Sakaida, Toshizo Ishikawa, Yuji Owada

    AMERICAN JOURNAL OF PATHOLOGY   184 ( 9 )   2505 - 2515   2014.9

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    DOI: 10.1016/j.ajpath.2014.05.015

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  • 急性肝不全 予後向上を目指す新規治療法の展望 他家骨髄由来の間葉系幹細胞を用いた急性肝不全に対する肝臓再生療法の可能性

    寺井 崇二, 高見 太郎, 坂井田 功

    肝臓   55 ( Suppl.2 )   A560 - A560   2014.9

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  • 当科における肝硬変による体液貯留に対するトルバプタン投与症例の検討

    田邉 規和, 寺井 崇二, 浦田 洋平, 内田 耕一, 坂井田 功

    肝臓   55 ( Suppl.2 )   A670 - A670   2014.9

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  • 高齢C型慢性患者における抗ウイルス療法の効果と肝発癌について

    花園 忠相, 日高 勲, 大野 高嗣, 岩本 拓也, 佐伯 一成, 石川 剛, 寺井 崇二, 坂井田 功

    肝臓   55 ( Suppl.2 )   A665 - A665   2014.9

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  • 肝細胞癌(HCC)に対し肝動脈化学塞栓術(TACE)施行後に腫瘍破裂を来した1例

    福井 悠美, 佐伯 一成, 花園 忠相, 田邊 規和, 浦田 洋平, 日高 勲, 寺井 崇二, 山崎 隆弘, 坂井田 功

    山口医学   63 ( 3 )   228 - 228   2014.8

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  • 【再生医療の最新の進歩(後篇) 組織工学とその臨床応用】再生医療本格化のための基盤テクノロジー 骨髄由来細胞を用いた肝再生療法の現状と展望

    田邉 規和, 高見 太郎, 寺井 崇二, 坂井田 功

    最新医学   69 ( 7月増刊 )   1438 - 1445   2014.7

  • 【単球・マクロファージの多様性と病態】骨髄由来細胞を用いた肝線維化改善療法

    寺井 崇二, 高見 太郎, 谷本 治子, 岩本 拓也, 坂井田 功

    血管医学   15 ( 2 )   157 - 160   2014.7

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  • 高齢者肝・胆・膵疾患の治療における諸問題 当科における高齢者肝細胞癌患者の現状と治療成績についての検討

    田邉 規和, 佐伯 一成, 浦田 洋平, 寺井 崇二, 坂井田 功

    日本高齢消化器病学会誌   17 ( 1 )   45 - 45   2014.7

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  • 当科における高齢C型慢性肝炎患者に対する抗ウイルス療法の特性

    花園 忠相, 日高 勲, 佐伯 一成, 岩本 拓也, 石川 剛, 寺井 崇二, 坂井田 功

    日本高齢消化器病学会誌   17 ( 1 )   79 - 79   2014.7

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  • Veno-occlusive diseaseを呈した薬物性肝障害の一例

    石川 剛, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   55 ( 7 )   441 - 441   2014.7

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  • Status and Prospects of Liver Cirrhosis Treatment by Using Bone Marrow-Derived Cells and Mesenchymal Cells Reviewed

    Shuji Terai, Taro Takami, Naoki Yamamoto, Koichi Fujisawa, Tsuyoshi Ishikawa, Yohei Urata, Haruko Tanimoto, Takuya Iwamoto, Yuko Mizunaga, Takashi Matsuda, Takashi Oono, Miho Marumoto, Guzel Burganova, Luiz Fernando Quintanilha, Isao Hidaka, Yoshio Marumoto, Issei Saeki, Koichi Uchida, Takahiro Yamasaki, Kenji Tani, Yasuho Taura, Yasuhiko Fujii, Hiroshi Nishina, Kiwamu Okita, Isao Sakaida

    TISSUE ENGINEERING PART B-REVIEWS   20 ( 3 )   206 - 210   2014.6

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    DOI: 10.1089/ten.teb.2013.0527

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  • Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma Reviewed

    Junichi Zaitsu, Takahiro Yamasaki, Issei Saeki, Yohei Harima, Takuya Iwamoto, Yumiko Harima, Toshihiko Matsumoto, Yohei Urata, Isao Hidaka, Yoshio Marumoto, Tsuyoshi Ishikawa, Taro Takami, Naoki Yamamoto, Seiji Kaino, Koichi Uchida, Shuji Terai, Isao Sakaida

    HEPATOLOGY RESEARCH   44 ( 5 )   481 - 490   2014.5

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    DOI: 10.1111/hepr.12141

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  • 造影エコーによる部分的脾動脈塞栓術の評価

    佐伯 一成, 石川 剛, 日高 勲, 高見 太郎, 寺井 崇二, 坂井田 功

    超音波医学   41 ( Suppl. )   S596 - S596   2014.4

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  • Sorafenibに対する徐放化DFOの血管新生に関する検討

    大野 高嗣, 寺井 崇二, 藤澤 浩一, 高見 太郎, 齊藤 高志, 田畑 泰彦, 坂井田 功

    肝臓   55 ( Suppl.1 )   A467 - A467   2014.4

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  • 当科外来に受診している肝硬変の成因別実態

    田邉 規和, 寺井 崇二, 岩本 拓也, 佐伯 一成, 浦田 洋平, 日高 勲, 石川 剛, 高見 太郎, 瀬川 誠, 内田 耕一, 坂井田 功

    肝臓   55 ( Suppl.1 )   A429 - A429   2014.4

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  • 臨床応用を視野に入れた肝再生研究の新たな展開 肝硬変に対する培養自己骨髄間葉系幹細胞投与による肝臓再生療法

    高見 太郎, 寺井 崇二, 坂井田 功

    肝臓   55 ( Suppl.1 )   A76 - A76   2014.4

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  • C型慢性肝炎に対するIFN治療前後での肝線維化の改善とElastographyによる肝硬度の変化

    日高 勲, 花園 忠相, 大野 高嗣, 佐伯 一成, 高見 太郎, 寺井 崇二, 坂井田 功

    超音波医学   41 ( Suppl. )   S601 - S601   2014.4

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  • 【再生医療技術の新展開】現在実現化に最も近い、外科領域における再生医療研究 骨髄細胞を用いた低侵襲な肝臓再生療法の開発

    松田 崇史, 高見 太郎, 寺井 崇二, 坂井田 功

    Surgery Frontier   21 ( 1 )   19 - 23   2014.3

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  • 【肝硬変-診断と治療の進歩】肝硬変治療の進歩 骨髄由来細胞を用いた肝再生治療の現状と展望

    白築 祥吾, 高見 太郎, 寺井 崇二, 坂井田 功

    臨床消化器内科   29 ( 4 )   479 - 484   2014.3

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  • Systemic Gemcitabine Combined with Hepatic Arterial Infusion Chemotherapy with Cisplatin, 5-Fluorouracil, and Isovorin for the Treatment of Advanced Intrahepatic Cholangiocarcinoma: A Pilot Study Reviewed

    Miho Marumoto, Takahiro Yamasaki, Yoshio Marumoto, Issei Saeki, Yohei Harima, Yohei Urata, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Makoto Segawa, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida

    HEPATO-GASTROENTEROLOGY   61 ( 129 )   162 - 167   2014.1

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    DOI: 10.5754/hge13455

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  • 肝臓 肝臓の再生療法

    高見 太郎, 寺井 崇二, 坂井田 功

    Annual Review消化器   2014   187 - 193   2014.1

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  • A Method of Bubble Removal for Computer-Assisted Diagnosis of Capsule Endoscopic Images. Reviewed

    Masato Suenaga, Yusuke Fujita, Shinichi Hashimoto, Shuji Terai, Isao Sakaida, Yoshihiko Hamamoto

    Modern Advances in Applied Intelligence - 27th International Conference on Industrial Engineering and Other Applications of Applied Intelligent Systems, IEA/AIE 2014, Kaohsiung, Taiwan, June 3-6, 2014, Proceedings, Part II   228 - 233   2014

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    DOI: 10.1007/978-3-319-07467-2_24

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  • Development of a Computer-Simulation Teaching Material Using Video Images for Endoscopic Education Concerning Gastric Cancer no.2:-Educational Practice and Its Assessment to Medical Students-

    OGASHIWA Kahori, HAMAMOTO Yoshihiko, FUJITA Yusuke, NISHIKAWA Jun, TERAI Shuji, SAKAIDA Isao

    Japanese Journal of Applied IT Healthcare   9 ( 2 )   22 - 33   2014

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    This study is intended as a follow-up of the &quot;Development of a Computer-Simulation Teaching Material Using Video Images for Endoscopic Education Concerning Gastric Cancer,&quot; which was published in Japanese Journal of Applied IT Healthcare in 2009. The purpose of this study is to evaluate simulation type materials for endoscopic education developed in the preceding paper. For this purpose, we conducted education for 82 medical students, and evaluated the learning history data of materials used. As a result, it was found that the eight quizzes in teaching materials are classified into 2 clusters according to the dependence on images. Further, in the evaluation of the extent diagnosis of the lesion with use of the criterion of &quot;detection rate - over-detection rate&quot;, it was found that a NBI (dye) image is suitable for diagnosis than a normal image. From the results of this study, in endoscopic education, it is difficult to learn skills obtained by solving the quizzes related to diagnosis of an image, by the conventional learning text. Thus, it is necessary to learn both the quizzes related to medical knowledge and the quizzes related to diagnosis of an image. It is recommended that to enhance the diagnosis ability, images are more used. From the reason for this, we suggest that e-learning using the images such as the video images has advantage, particularly in endoscopic education.

    DOI: 10.11204/ithc.9.22

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  • Tolvaptan for improvement of hepatic edema: A phase 3, multicenter, randomized, double-blind, placebo-controlled trial

    Sakaida, I., Kawazoe, S., Kajimura, K., Saito, T., Okuse, C., Takaguchi, K., Okada, M., Okita, K., Masumoto, A., Kaneko, A., Inoue, A., Hasebe, C., Takesaki, E., Hayashi, E., Ohta, H., Morimoto, H., Yoshihara, H., Nishimura, H., Tsuruta, H., Ario, K., Iwase, H., Tanimura, H., Kumada, H., Hasegawa, H., Kohno, H., Hidaka, H., Moriwaki, H., Kobayashi, I., Shimoda, K., Tsuji, K., Yamamoto, K., Yokota, K., Yamauchi, M., Takahashi, M., Inada, M., Kawaguchi, M., Kudo, M., Tanaka, M., Mihara, M., Suzuki, M., Kato, M., Kitamoto, M., Murata, M., Higashi, N., Chida, N., Mano, Y., Inoue, O., Takano, S., Nakayama, S., Hayashi, S., Fujiyama, S., Fujioka, S., Shimizu, S., Katsushima, S., Kitamura, S., Kira, S., Nagaoka, S., Terai, S., Watanabe, S., Takahashi, S., Inoue, S., Yamaguchi, T., Satoh, T., Azuma, T., Igura, T., Komatsu, T., Tamura, T., Ito, T., Ueki, T., Muro, T., Morita, T., Nishigaki, Y., Ohnishi, Y., Karino, Y., Narahara, Y., Osaki, Y.

    Hepatology Research   44 ( 1 )   2014

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    DOI: 10.1111/hepr.12098

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  • Dose-finding trial of tolvaptan in liver cirrhosis patients with hepatic edema: A randomized, double-blind, placebo-controlled trial

    Okita, K., Kawazoe, S., Hasebe, C., Kajimura, K., Kaneko, A., Okada, M., Sakaida, I., Inoue, A., Yoshihara, H., Kumada, H., Ikeda, K., Kohno, H., Hidaka, H., Moriwaki, H., Inoue, J., Nakatsuka, K., Chayama, K., Katayama, K., Fujimura, K., Tsuji, K., Kumamoto, M., Yamazaki, M., Kawaguchi, M., Yoneda, M., Tanaka, M., Kato, M., Kitamoto, M., Endo, R., Suzuki, S., Watanabe, S., Kaneda, S., Yamashita, S., Nakayama, S., Kokubu, S., Tanaka, S., Katsushima, S., Aimitsu, S., Terai, S., Kawata, S., Saito, T., Ueki, T., Nouchi, T., Ohnishi, Y., Nishigaki, Y.

    Hepatology Research   44 ( 1 )   2014

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    DOI: 10.1111/hepr.12099

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  • Re-response to tolvaptan after furosemide dose reduction in a patient with refractory ascites Reviewed

    Atsushi Goto, Shuji Terai, Munetaka Nakamura, Masaharu Matsumoto, Isao Sakaida

    Clinical Journal of Gastroenterology   8 ( 1 )   47 - 51   2014

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    DOI: 10.1007/s12328-014-0545-8

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  • Hepatic Crown-Like Structure: A Unique Histological Feature in Non-Alcoholic Steatohepatitis in Mice and Humans Reviewed

    Michiko Itoh, Hideaki Kato, Takayoshi Suganami, Kuniha Konuma, Yoshio Marumoto, Shuji Terai, Hiroshi Sakugawa, Sayaka Kanai, Miho Hamaguchi, Takahiro Fukaishi, Seiichiro Aoe, Kazunari Akiyoshi, Yoshihiro Komohara, Motohiro Takeya, Isao Sakaida, Yoshihiro Ogawa

    PLOS ONE   8 ( 12 )   e82163   2013.12

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    DOI: 10.1371/journal.pone.0082163

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  • Improvement of liver fibrosis by infusion of cultured cells derived from human bone marrow Reviewed

    Haruko Tanimoto, Shuji Terai, Takami Taro, Yasuhiko Murata, Kouichi Fujisawa, Naoki Yamamoto, Isao Sakaida

    CELL AND TISSUE RESEARCH   354 ( 3 )   717 - 728   2013.12

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    DOI: 10.1007/s00441-013-1727-2

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  • ソラフェニブの関与が疑われたネフローゼ症候群の2例

    田邉 規和, 浦田 洋平, 白築 祥吾, 岩本 拓也, 佐伯 一成, 播磨 夕美子, 日高 勲, 丸本 芳雄, 石川 剛, 高見 太郎, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   54 ( Suppl.3 )   A857 - A857   2013.11

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  • 限局性結節性過形成と鑑別困難であった巨大肝細胞癌の一例

    佐伯 一成, 大野 高嗣, 浦田 洋平, 高見 太郎, 寺井 崇二, 山崎 隆弘, 徳久 善弘, 為佐 卓夫, 坂井田 功

    超音波医学   40 ( 6 )   667 - 667   2013.11

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  • 肝移植と再生医療のクロストーク 自己骨髄細胞による肝臓再生療法の取り組み

    高見 太郎, 寺井 崇二, 坂井田 功

    肝臓   54 ( Suppl.3 )   A666 - A666   2013.11

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  • エゼチミブのNASHに対する作用機序および臨床使用経験についての検討

    大野 高嗣, 寺井 崇二, 大石 俊之, 桑代 紳哉, 藤澤 浩一, 丸本 芳雄, 坂井田 功

    肝臓   54 ( Suppl.3 )   A799 - A799   2013.11

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  • A study of liver cirrhosis classification on m-mode ultrasound images by higher-order local auto-correlation features

    K. Fujino, Y. Mitani, T. Hayashi, Y. Fujita, Y. Hamamoto, M. Segawa, S. Terai, I. Sakaida

    Proceedings of the SICE Annual Conference   1403 - 1404   2013.9

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  • 再生医療の最前線 肝硬変症に対する骨髄由来細胞を用いた再生療法

    寺井 崇二, 高見 太郎, 坂井田 功

    日本内分泌学会雑誌   89 ( 2 )   723 - 723   2013.9

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  • NASH発症におけるhepatic crown-like structureの意義

    伊藤 美智子, 菅波 孝祥, 小沼 邦葉, 丸本 芳雄, 寺井 崇二, 佐久川 廣, 坂井田 功, 小川 佳宏

    肥満研究   19 ( Suppl. )   156 - 156   2013.9

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  • 当科における肝細胞癌に対するソラフェニブ(SF)治療の検証

    花園 忠相, 浦田 洋平, 岩本 拓也, 佐伯 一成, 日高 勲, 丸本 芳雄, 石川 剛, 高見 太郎, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    山口医学   62 ( 3 )   175 - 175   2013.8

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  • The expanding role of fish models in understanding non-alcoholic fatty liver disease Reviewed

    Yoichi Asaoka, Shuji Terai, Isao Sakaida, Hiroshi Nishina

    DISEASE MODELS & MECHANISMS   6 ( 4 )   905 - 914   2013.7

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  • 【細胞移植】肝硬変症に対する自己骨髄由来培養髄細胞を用いた再生細胞療法

    寺井 崇二, 高見 太郎, 坂井田 功

    細胞   45 ( 7 )   327 - 329   2013.7

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  • Correlations between Obesity/Metabolic Syndrome-Related Factors and Risk of Developing Colorectal Tumors Reviewed

    Satoko Harima, Shinichi Hashimoto, Hiroaki Shibata, Takaharu Matsunaga, Ryo Tanabe, Shuji Terai, Isao Sakaida

    HEPATO-GASTROENTEROLOGY   60 ( 124 )   733 - 737   2013.6

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    DOI: 10.5754/hge12895

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  • Bortezomib induces tumor-specific cell death and growth inhibition in hepatocellular carcinoma and improves liver fibrosis Reviewed

    Issei Saeki, Shuji Terai, Koichi Fujisawa, Taro Takami, Naoki Yamamoto, Toshihiko Matsumoto, Yoshikazu Hirose, Yasuhiko Murata, Takahiro Yamasaki, Isao Sakaida

    Journal of Gastroenterology   48 ( 6 )   738 - 750   2013.6

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    DOI: 10.1007/s00535-012-0675-z

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  • チロシンは、C型慢性肝障害におけるインスリン抵抗性の新たなバイオマーカーとなり得る

    在津 潤一, 山崎 隆弘, 佐伯 一成, 岩本 拓也, 播磨 夕美子, 丸本 芳雄, 日高 勲, 浦田 洋平, 石川 剛, 高見 太郎, 瀬川 誠, 内田 耕一, 寺井 崇二, 坂井田 功

    肝臓   54 ( Suppl.1 )   A238 - A238   2013.4

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  • 短期間で興味深いエコー像変化を呈した肝細胞癌の一例

    佐伯 一成, 日高 勲, 松永 一仁, 高見 太郎, 寺井 崇二, 山崎 隆弘, 坂井田 功

    超音波医学   40 ( Suppl. )   S534 - S534   2013.4

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  • 当科における肝細胞癌に対するソラフェニブ治療の検証 とくに肝予備能と病勢制御に着目して

    浦田 洋平, 山崎 隆弘, 佐伯 一成, 岩本 拓也, 播磨 夕美子, 日高 勲, 石川 剛, 高見 太郎, 内田 耕一, 寺井 崇二, 坂井田 功

    肝臓   54 ( Suppl.1 )   A284 - A284   2013.4

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  • Bone-marrow-derived cells cultured in serum-free medium reduce liver fibrosis and improve liver function in carbon-tetrachloride-treated cirrhotic mice Reviewed

    Takuya Iwamoto, Shuji Terai, Takuro Hisanaga, Taro Takami, Naoki Yamamoto, Shoko Watanabe, Isao Sakaida

    CELL AND TISSUE RESEARCH   351 ( 3 )   487 - 495   2013.3

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    DOI: 10.1007/s00441-012-1528-z

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  • 【肝疾患と幹細胞をめぐる進歩】骨髄細胞投与による肝硬変症に対する肝再生・発癌抑制療法

    高見 太郎, 前田 雅喜, 寺井 崇二, 坂井田 功

    消化器内科   56 ( 3 )   324 - 330   2013.3

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  • Progression from Non-alcoholic Steatohepatitis (NASH) to Decompensated Liver Cirrhosis during the Course of Crohn' s Disease : A Case Report

    TANABE Norikazu, HARIMA Yumiko, HASHIMOTO Shinichi, TERAI Shuji, YAMASAKI Takahiro, SAKAIDA Isao

    山口医学   62 ( 1 )   33 - 37   2013.2

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    症例は31歳の女性.18歳時にCrohn病と診断され,当科での治療を開始された.経腸栄養療法や5-ASA製剤,ステロイドや抗TNFα抗体製剤等の内科的治療を行うも効果不十分であり,消化管合併症の悪化から24歳時に回腸部分切除術,26歳時に回盲部切除術,28歳時に回腸および上行結腸切除術を施行し,残存小腸は約280cmとなった.その後も症状は安定せず,成分栄養剤による経腸栄養療法を勧めるも患者の理解が得られず,長期の絶食および中心静脈栄養を施行していた.31歳時頃より,見当識障害および活動性低下が認められたため当科入院となった.腹部骨盤単純CT検査上,肝萎縮を伴う肝硬変の状態と考えられ,血液生化学検査にて著明な肝機能障害およびアンモニア値の上昇を認めたため,非代償性肝硬変症による肝性脳症と診断された.血液検査上HBVおよびHCV感染は否定され,飲酒歴もなく,以前より脂肪肝が認められ,肝胆道系酵素の上昇も認められていたことから,非アルコール性脂肪性肝炎(NASH)による非代償性肝硬変と診断した.年齢と肝機能から肝移植を考慮したが,適したドナーがいなかったことと,患者が肝移植を希望しなかったことから対症療法を継続した.その後もCrohn病や肝硬変の加療で入退院を繰り返し肝不全により死亡した.重症Crohn病の経過中に複数の要因からNASHを併発し非代償性肝硬変症へ進展した,極めてまれな症例を経験したため報告する.The patient was a 31-year-old woman who had been diagnosed with Crohn&#039;s disease at age 18 years. Enteral nutrition and medical treatment were given, but their effect was insufficient. Gastrointestinal complications worsened, and ileocecal resection was performed three times. The remaining small intestine was 280 cm. But, her symptoms were unstable. Thus long-term fasting and central venous nutrition were adopted. At 31 years old, she was hospitalized with cognitive dysfunction and decreased activity. CT scan showed liver cirrhosis(LC),and hepatic dysfunction and an elevated ammonia level were seen on blood tests. Therefore, she was diagnosed as hepatic encephalopathy from decompensated LC. Blood tests were negative for HBV and HCV infections, she had no history of drinking alcohol, fatty liver had been presented for some time, and elevated transaminase were seen. This led to a diagnosis of LC resulting from non-alcoholic steatohepatitis(NASH).Liver transplantation was considered, but there was no appropriate donor, and the patient did not desire. Therefore, symptomatic therapy was continued. She was repeatedly hospitalized and finally died from liver failure. We report that the rare case in which NASH occurred due to multiple factors during the course of severe Crohn&#039;s disease and progressed to decompensated LC.

    DOI: 10.2342/ymj.62.33

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  • Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy Reviewed

    Koichiro Ichimura, Yusuke Kawashima, Tomomi Nakamura, Rebecca Powell, Yuya Hidoh, Shuji Terai, Isao Sakaida, Yoshio Kodera, Takashi Tsuji, Jian-Xing Ma, Tatsuo Sakai, Hiroyuki Matsumoto, Tomoko Obara

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   431 ( 4 )   712 - 717   2013.2

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  • 消化器領域における幹細胞研究の進歩 培養骨髄由来細胞を用いた肝硬変症に対する修復療法の開発へのProof of Concept

    寺井 崇二, 高見 太郎, 坂井田 功

    日本消化器病学会雑誌   110 ( 臨増総会 )   A83 - A83   2013.2

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  • 【再生医療の実現化に向けて】肝硬変症に対する自己骨髄細胞投与療法

    丸本 美穂, 寺井 崇二, 丸本 芳雄, 高見 太郎, 坂井田 功

    炎症と免疫   21 ( 2 )   142 - 147   2013.2

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  • 肝線維化の診断と臨床 自己骨髄細胞による肝硬変に対する再生修復療法の現状と展望

    高見 太郎, 寺井 崇二, 坂井田 功

    Japanese Journal of Diagnostic Imaging   31 ( 1 )   30 - 30   2013.2

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  • An improvement of liver cirrhosis classification using ultrasonic images

    Hayashi, T., Fujita, Y., Mitani, Y., Hamamoto, Y., Segawa, M., Terai, S., Sakaida, I.

    IEEJ Transactions on Electronics, Information and Systems   133 ( 2 )   289 - 296   2013.1

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    DOI: 10.1541/ieejeiss.133.289

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  • 肝臓 肝臓の再生療法

    高見 太郎, 寺井 崇二, 坂井田 功

    Annual Review消化器   2013   196 - 202   2013.1

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  • A liver cirrhosis detection method using probabilistic ROI combination Reviewed

    Y. Fujita, T. Goto, Y. Mitani, Y. Hamamoto, M. Segawa, S. Terai, I. Sakaida

    Proceedings of 11th International Conference on Quality Control by Artificial Vision   81 - 85   2013

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  • 超音波画像を用いた肝硬変識別の高精度化 Reviewed

    林 孝哉, 藤田 悠介, 三谷 芳弘, 浜本 義彦, 瀬川 誠, 寺井 崇二, 坂井田 功

    電気学会論文誌C   133 ( 2 )   289 - 296   2013

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  • A note of liver cirrhosis classification on M-mode ultrasound images by higher-order local auto-correlation features. Reviewed

    K. Fujino, Yoshihiro Mitani, T. Hayashi, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Segawa, Shuji Terai, Isao Sakaida

    2013 International Conference on Soft Computing and Pattern Recognition, SoCPaR 2013, Hanoi, Vietnam, December 15-18, 2013   50 - 53   2013

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  • Liver Resident Stem Cell Reviewed

    Christina M. Takiya, Bruno Diaz Paredes, Luiz Fernando Quintanilha de Mesquita, Grazielle Suhett Dias, Lanuza Alaby Pinheiro Faccioli, Taro Takami, Shuji Terai, Isao Sakaida, Regina Coeli dos Santos Goldenberg

    Resident Stem Cells and Regenerative Therapy   177 - 203   2013

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    DOI: 10.1016/B978-0-12-416012-5.00010-4

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  • 肝疾患に対する先端医療 骨髄由来培養細胞を用いた肝臓修復再生療法の実現化準備 ヒト幹細胞を用いた臨床指針を踏まえて

    寺井 崇二, 高見 太郎, 坂井田 功

    日本消化器病学会雑誌   109 ( 臨増大会 )   A424 - A424   2012.9

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  • 骨髄細胞投与による酸化ストレス制御を介した肝発癌抑制メカニズムの解明

    高見 太郎, 寺井 崇二, 前田 雅喜, 坂井田 功

    日本消化器病学会雑誌   109 ( 臨増大会 )   A721 - A721   2012.9

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  • Advanced Therapies Using Autologous Bone Marrow Cells for Chronic Liver Disease Reviewed

    Taro Takami, Shuji Terai, Isao Sakaida

    DISCOVERY MEDICINE   14 ( 74 )   7 - 12   2012.7

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  • 【肝硬変update より良き診療のために】肝硬変診療のトピックス 自己骨髄細胞を用いた肝修復再生療法の現状

    高見 太郎, 寺井 崇二, 坂井田 功

    Medicina   49 ( 7 )   1238 - 1239   2012.7

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  • Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma Reviewed

    Takahiro Yamasaki, Issei Saeki, Yohei Harima, Junichi Zaitsu, Masaki Maeda, Haruko Tanimoto, Takuya Iwamoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY   47 ( 6 )   715 - 722   2012.6

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    DOI: 10.1007/s00535-012-0537-8

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  • Therapeutic Potential of Canine Bone Marrow Stromal Cells (BMSCs) in the Carbon Tetrachloride (CCl4) Induced Chronic Liver Dysfunction Mouse Model Reviewed

    Tomoya Haraguchi, Kenji Tani, Ryo Takagishi, Yasutaka Oda, Kazuhito Itamoto, Naoki Yamamoto, Shuji Terai, Isao Sakaida, Hiroshi Nakazawa, Yasuho Taura

    JOURNAL OF VETERINARY MEDICAL SCIENCE   74 ( 5 )   607 - 611   2012.5

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    DOI: 10.1292/jvms.11-0505

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  • Stem cell therapy in chronic liver disease Reviewed

    Taro Takami, Shuji Terai, Isao Sakaida

    CURRENT OPINION IN GASTROENTEROLOGY   28 ( 3 )   203 - 208   2012.5

  • Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy Reviewed

    Shuji Terai, Haruko Tanimoto, Masaki Maeda, Junichi Zaitsu, Takuro Hisanaga, Takuya Iwamoto, Koichi Fujisawa, Yuko Mizunaga, Toshihiko Matsumoto, Yohei Urata, Yoshio Marumoto, Isao Hidaka, Tsuyoshi Ishikawa, Yuichiro Yokoyama, Koji Aoyama, Masako Tsuchiya, Taro Takami, Kaoru Omori, Naoki Yamamoto, Makoto Segawa, Koichi Uchida, Takahiro Yamasaki, Kiwamu Okita, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY   47 ( 5 )   491 - 497   2012.5

  • Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model Reviewed

    Toshiyuki Oishi, Shuji Terai, Shinya Kuwashiro, Koichi Fujisawa, Toshihiko Matsumoto, Hiroshi Nishina, Isao Sakaida

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   422 ( 1 )   22 - 27   2012.5

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  • Matrix Metalloproteinases (MMPs) Activity in Cultured Canine Bone Marrow Stromal Cells (BMSCs) Reviewed

    Tomoya Haraguchi, Kenji Tani, Masato Koga, Yasutaka Oda, Kazuhito Itamoto, Naoki Yamamoto, Shuji Terai, Isao Sakaida, Hiroshi Nakazawa, Yasuho Taura

    JOURNAL OF VETERINARY MEDICAL SCIENCE   74 ( 5 )   633 - 636   2012.5

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  • Clear cell typeの肝細胞癌の一例

    土屋 昌子, 石川 剛, 高見 太郎, 寺井 崇二, 山崎 隆弘, 坂井田 功

    超音波医学   39 ( Suppl. )   S408 - S408   2012.4

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  • Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients Reviewed

    Takuya Iwamoto, Shuji Terai, Yuko Mizunaga, Naoki Yamamoto, Kaoru Omori, Koichi Uchida, Takahiro Yamasaki, Yasuhiko Fujii, Hiroshi Nishina, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY   47 ( 3 )   300 - 312   2012.3

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    DOI: 10.1007/s00535-011-0486-7

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  • Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver cirrhosis Reviewed

    Masaki Maeda, Taro Takami, Shuji Terai, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   27   104 - 111   2012.3

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    DOI: 10.1111/j.1440-1746.2011.07016.x

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  • Hepatic Arterial Infusion Chemotherapy in Combination with Pegylated Interferon-alpha-2b for Advanced Hepatocellular Carcinoma Reviewed

    Kohsuke Okita, Takahiro Yamasaki, Sotoe Hamabe, Issei Saeki, Yohei Harima, Shuji Terai, Isao Sakaida

    HEPATO-GASTROENTEROLOGY   59 ( 114 )   533 - 537   2012.3

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  • 当科における肝細胞癌に対するsorafenibの治療成績

    浦田 洋平, 山崎 隆弘, 在津 潤一, 日高 勲, 石川 剛, 土屋 昌子, 内田 耕一, 寺井 崇二, 坂井田 功

    日本消化器病学会雑誌   109 ( 臨増総会 )   A281 - A281   2012.3

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  • 肝臓 肝臓の再生治療

    高見 太郎, 寺井 崇二, 坂井田 功

    Annual Review消化器   2012   192 - 197   2012.1

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  • Advanced therapies using autologous bone marrow cells for chronic liver disease.

    Takami, T., Terai, S., Sakaida, I.

    Discovery medicine   14 ( 74 )   2012

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  • Granulocyte Colony-Stimulating Factor and Interleukin-1 beta Are Important Cytokines in Repair of the Cirrhotic Liver After Bone Marrow Cell Infusion: Comparison of Humans and Model Mice Reviewed

    Yuko Mizunaga, Shuji Terai, Naoki Yamamoto, Koichi Uchida, Takahiro Yamasaki, Hiroshi Nishina, Yusuke Fujita, Koh Shinoda, Yoshihiko Hamamoto, Isao Sakaida

    CELL TRANSPLANTATION   21 ( 11 )   2363 - 2375   2012

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    DOI: 10.3727/096368912X638856

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  • Autologous bone marrow cell infusion therapy to repair and regenerate liver Reviewed

    Shuji Terai, Isao Sakaida

    Seikagaku   84 ( 8 )   707 - 711   2012

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  • A Case of Ruptured Duodenal Varices Treated by Combination Therapy of Endoscopic Variceal Ligation and Balloon-occluded Retrograde Transvenous Obliteration

    MATSUDA Takashi, ISHIKAWA Tsuyoshi, SUENAGA Shigeyuki, GOTO Atsushi, HAMABE Kouichi, IWAMOTO Takuya, HASHIMOTO Shinichi, NAKASHIMA Yoshiteru, OKADA Munemasa, UCHIDA Koichi, TERAI Shuji, YAMASAKI Takahiro, SAKAIDA Isao

    山口医学   60 ( 6 )   237 - 242   2011.12

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    57歳の男性.B型肝硬変・肝細胞癌に対して外来経過観察中,下血に対する精査加療目的で当科に緊急入院した.上部消化管内視鏡検査(EGD)で十二指腸下行脚に静脈瘤が認められたものの活動性出血および血液貯留の所見はなく,下部消化管内視鏡検査・カプセル内視鏡検査・経肛門的ダブルバルーン内視鏡検査においても回腸~結腸内に凝血塊の貯留が認められたのみで出血源の同定には至らなかった.腹部血管造影検査では十二指腸周辺に著明な門脈系-大循環系短絡路の発達が認められ,血管造影下CTで十二指腸下行脚付近に造影剤の血管外漏出が疑われた.直後の緊急EGDにより十二指腸静脈瘤破裂と診断し,内視鏡的静脈瘤結紮術(EVL)にて一次止血に成功した.しかしその2日後に出血性ショックに陥ったため,EVLで止血した上で引き続きバルーン閉塞下逆行性経静脈的塞栓術(B-RTO)を施行して完全止血を得た.十二指腸静脈瘤破裂は非常に稀な難治性消化管出血であるが,今回我々はEVL・B-RTO併用療法で止血し救命し得た症例を経験したので報告する.A 57-year-old male with hepatitis B virus-related liver cirrhosis, who had undergone right lobectomy and radiofrequency ablation for hepatocellular carcinoma, was admitted to our department for the purpose of examination and treatment of melena. Esophagogastroduodenoscopy (EGD) on admission showed duodenal varices without active bleeding in the 2nd portion of duodenum. In addition, total colonoscopy, capsule endoscopy, and double-balloon endoscopy via the anal demonstrated massive dark-red clot in the ileum and colon, but not pointed out a source of bleeding. Thereafter, the angiography via superior mesenteric artery revealed large portalsystemic shunts around the duodenum and computed tomography during arteriography showed extravasation at the 2nd portion of duodenum. Urgent EGD enabled us to diagnose as ruptured duodenal varices and endoscopic variceal ligation (EVL) was successfully performed. However, two days later, he suffered from hemorrhagic shock because of rebleeding of duodenal varices and balloon-occluded retrograde transvenous obliteration (B-RTO) after second EVL finally led to complete hemostasis. We report this rare case of ruptured duodenal varices treated by combination therapy of EVL and BRTO in a cirrhotic patient.

    DOI: 10.2342/ymj.60.237

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  • A Case of Neuroendcrine Tumor of the Ileum with Liver Metastases Treated with Transcatheter Arterial Chemoembolization with Degradable Starch Microspheres and Biotherapy with Octreotide

    OONO Takashi, SEGAWA Makoto, HASHIMOTO Shinichi, UCHIDA Koichi, TERAI Shuji, YAMASAKI Takahiro, HOSHII Yoshinobu, SAKAIDA Isao

    Yamaguchi Medical Journal   60 ( 6 )   255 - 261   2011.12

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    We report a case of neuroendocrine tumor of the ileum with liver metastases. A 50 year-old level woman was pointed out multiple liver tumors by the abdominal ultrasonography and admitted to our hospital. Histological diagnosis was neuroendocrine tumor G1 (WHO classification) on tumor biopsy of the liver. Multiple ileum tumors were found on endoscopic examination of the ileum using double balloon endoscopy and assessed as a primary lesion. Transcatheter arterial infusion chemotherapy using iodized oil (lipiodol) and degradable starch microspheres (Lip-TAI using DSM) was performed for the metastatic lesion of the liver, and tumor regression was observed. Long-acting somatostatin analogue (octreotide) was administered once a month as an additional therapy. Inhibition of the tumor proliferation in both primary and metastatic lesion was observed for about 2 years. Combination therapy with Lip-TAI using DSM and biotherapy with octreotide will be a promising therapy for unresectable neuroendocrine tumor with liver metastases.

    DOI: 10.2342/ymj.60.255

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  • Melanocortin 4 Receptor-Deficient Mice as a Novel Mouse Model of Nonalcoholic Steatohepatitis Reviewed

    Michiko Itoh, Takayoshi Suganami, Nobutaka Nakagawa, Miyako Tanaka, Yukio Yamamoto, Yasutomi Kamei, Shuji Terai, Isao Sakaida, Yoshihiro Ogawa

    AMERICAN JOURNAL OF PATHOLOGY   179 ( 5 )   2454 - 2463   2011.11

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    DOI: 10.1016/j.ajpath.2011.07.014

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  • 肝細胞癌・慢性関節リウマチの加療中に悪性リンパ腫を発症した一例

    播磨 博文, 石川 剛, 土屋 昌子, 内田 耕一, 星井 嘉信, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   52 ( Suppl.3 )   A954 - A954   2011.11

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  • TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion Reviewed

    Takuro Hisanaga, Shuji Terai, Takuya Iwamoto, Taro Takami, Naoki Yamamoto, Tomoaki Murata, Toshifumi Matsuyama, Hiroshi Nishina, Isao Sakaida

    CELL AND TISSUE RESEARCH   346 ( 1 )   79 - 88   2011.10

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    DOI: 10.1007/s00441-011-1236-0

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  • Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish Reviewed

    Koichi Fujisawa, Shuji Terai, Yoshikazu Hirose, Taro Takami, Naoki Yamamoto, Isao Sakaida

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   414 ( 2 )   331 - 336   2011.10

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    DOI: 10.1016/j.bbrc.2011.09.067

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  • Potential Therapeutic Application of Intravenous Autologous Bone Marrow Infusion in Patients with Alcoholic Liver Cirrhosis Reviewed

    Takafumi Saito, Kazuo Okumoto, Hiroaki Haga, Yuko Nishise, Rika Ishii, Chikako Sato, Hisayoshi Watanabe, Akio Okada, Motoki Ikeda, Hitoshi Togashi, Tsuyoshi Ishikawa, Shuji Terai, Isao Sakaida, Sumio Kawata

    STEM CELLS AND DEVELOPMENT   20 ( 9 )   1504 - 1511   2011.9

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    DOI: 10.1089/scd.2011.0074

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  • 肝疾患と幹細胞 炎症、再生、発癌まで 骨髄細胞頻回投与による肝細胞がん合併肝硬変症に対する修復再生・抗腫瘍療法開発のための基礎研究

    高見 太郎, 寺井 崇二, 坂井田 功

    日本消化器病学会雑誌   108 ( 臨増大会 )   A687 - A687   2011.9

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  • 肝疾患動物モデルとtranslational research 肝硬変症に対する骨髄由来培養細胞を用いた修復再生療法開発のために橋渡し研究

    寺井 崇二, 高見 太郎, 坂井田 功

    日本消化器病学会雑誌   108 ( 臨増大会 )   A566 - A566   2011.9

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  • Deferoxamine for Advanced Hepatocellular Carcinoma Reviewed

    Takahiro Yamasaki, Shuji Terai, Isao Sakaida

    NEW ENGLAND JOURNAL OF MEDICINE   365 ( 6 )   576 - 578   2011.8

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  • 内視鏡的静脈瘤硬化結紮療法後におけるAT3製剤投与による門脈血栓予防効果

    浜辺 功一, 石川 剛, 岩本 拓也, 瀬川 誠, 寺井 崇二, 山崎 隆弘, 坂井田 功

    日本門脈圧亢進症学会雑誌   17 ( 3 )   111 - 111   2011.8

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  • A case of liver metastasis from ocular melanoma with difficulty in distinguishing from hepatocellular carcinoma

    ZAITSU Junichi, ISHIKAWA Tsuyoshi, HARIMA Yohei, TSUCHIYA Masako, TAKAMI Taro, YAMAGUCHI Yuhki, UCHIDA Koichi, TERAI Shuji, YAMASAKI Takahiro, SAKAIDA Isao

    Kanzo   52 ( 7 )   468 - 476   2011.7

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    DOI: 10.2957/kanzo.52.468

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  • An abdominal aorta wall extraction for liver cirrhosis classification using ultrasonic images

    Takaya Hayashi, Yusuke Fujita, Yoshihiro Mitani, Yoshihiko Hamamoto, Makoto Segawa, Shuji Terai, Isao Sakaida

    AIP Conference Proceedings   1371   343 - 344   2011.7

  • Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet Reviewed

    Toshiyuki Oishi, Shuji Terai, Takuya Iwamoto, Taro Takami, Naoki Yamamoto, Isao Sakaida

    HEPATOLOGY RESEARCH   41 ( 5 )   463 - 474   2011.5

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    DOI: 10.1111/j.1872-034X.2011.00784.x

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  • Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation Reviewed

    Shinya Kuwashiro, Shuji Terai, Toshiyuki Oishi, Koichi Fujisawa, Toshihiko Matsumoto, Hiroshi Nishina, Isao Sakaida

    CELL AND TISSUE RESEARCH   344 ( 1 )   125 - 134   2011.4

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    DOI: 10.1007/s00441-011-1132-7

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  • Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver Reviewed

    Norio Miyamura, Takashi Nakamura, Naoko Goto-Inoue, Nobuhiro Zaima, Takahiro Hayasaka, Tokiwa Yamasaki, Shuji Terai, Isao Sakaida, Mitsutoshi Setou, Hiroshi Nishina

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   408 ( 1 )   120 - 125   2011.4

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    DOI: 10.1016/j.bbrc.2011.03.133

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  • HHMは肝細胞増殖を抑制する

    藤澤 浩一, 寺井 崇二, 桑代 紳哉, 松本 俊彦, 高見 太郎, 山本 直樹, 坂井田 功

    肝臓   52 ( Suppl.1 )   A198 - A198   2011.4

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  • 肝再生医学研究の新展開 効率的な肝硬変症に対する骨髄細胞を用いた修復再生療法の開発のための基礎的検討

    寺井 崇二, 高見 太郎, 坂井田 功

    肝臓   52 ( Suppl.1 )   A117 - A117   2011.4

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  • A novel transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma: a prospective randomized trial Reviewed

    Takahiro Yamasaki, Satoe Hamabe, Issei Saeki, Yohei Harima, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY   46 ( 3 )   359 - 366   2011.3

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    DOI: 10.1007/s00535-010-0306-5

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  • Current State and Future Prospects for Our Liver Regeneration Therapy Using Autologous Bone Marrow Cells for Decompensated Liver Cirrhosis Patients Reviewed

    Taro Takami, Shuji Terai, Isao Sakaida

    JOURNAL OF PHARMACOLOGICAL SCIENCES   115 ( 3 )   274 - 278   2011.3

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  • 非代償性肝硬変の合併症とその対策 肝硬変症に対する次世代型骨髄由来培養細胞を用いた修復再生療法の開発

    寺井 崇二, 高見 太郎, 坂井田 功

    日本消化器病学会雑誌   108 ( 臨増総会 )   A147 - A147   2011.3

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  • 当科で経験したHBVキャリア 急性増悪を来たした二例

    内田 耕一, 瀬川 誠, 柴田 大明, 植木谷 俊之, 播磨 陽平, 土屋 昌子, 石川 剛, 寺井 崇二, 山崎 隆弘, 坂井田 功, 加藤 彰, 木村 輝明, 山下 智省, 沖田 極

    肝臓   52 ( 3 )   222 - 222   2011.3

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  • Autologous bone marrow cell infusion therapy for liver cirrhosis patients Reviewed

    Shuji Terai, Isao Sakaida

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   18 ( 1 )   23 - 25   2011.1

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    DOI: 10.1007/s00534-010-0305-1

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  • Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers Reviewed

    Norio Iizuka, Masaaki Oka, Isao Sakaida, Toyoki Moribe, Toshiaki Miura, Naoki Kimura, Shigeru Tamatsukuri, Hideo Ishitsuka, Koichi Uchida, Shuji Terai, Satoyoshi Yamashita, Kiwamu Okita, Koichiro Sakata, Yoshiyasu Karino, Joji Toyota, Eiji Ando, Tatsuya Ide, Michio Sata, Ryoichi Tsunedomi, Masahito Tsutsui, Michihisa Iida, Yoshihiro Tokuhisa, Kazuhiko Sakamoto, Takao Tamesa, Yusuke Fujita, Yoshihiko Hamamoto

    CLINICA CHIMICA ACTA   412 ( 1-2 )   152 - 158   2011.1

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    DOI: 10.1016/j.cca.2010.09.028

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  • 肝臓 肝疾患の再生治療

    高見 太郎, 寺井 崇二, 坂井田 功

    Annual Review消化器   2011   223 - 228   2011.1

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  • C型慢性肝炎におけるエラストグラフィの有用性

    江角 智子, 高見 太郎, 岸田 由香里, 堤 寛子, 松尾 亜矢, 石川 剛, 瀬川 誠, 寺井 崇二, 山崎 隆弘, 坂井田 功

    超音波医学   37 ( 6 )   679 - 679   2010.11

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  • Sonazoid造影エコー検査では肝細胞癌との鑑別が困難であった脈絡膜悪性黒色腫肝転移の一例

    大石 俊之, 石川 剛, 土屋 昌子, 高見 太郎, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    超音波医学   37 ( 6 )   676 - 677   2010.11

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  • 門脈圧亢進症における病態進行度の指標としての肝弾性値の有用性

    瀬川 誠, 浜辺 功一, 石川 剛, 寺井 崇二, 山崎 隆弘, 坂井田 功

    超音波医学   37 ( 6 )   679 - 679   2010.11

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  • Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells Reviewed

    Junko K. Akada, Hiroki Aoki, Yuji Torigoe, Takao Kitagawa, Hisao Kurazono, Hisashi Hoshida, Jun Nishikawa, Shuji Terai, Masunori Matsuzaki, Toshiya Hirayama, Teruko Nakazawa, Rinji Akada, Kazuyuki Nakamura

    DISEASE MODELS & MECHANISMS   3 ( 9-10 )   605 - 617   2010.9

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    DOI: 10.1242/dmm.004879

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  • 肝臓の再生機構を考える 今後の肝再生医療への展望 骨髄由来Liver Repair cell(LR細胞)を用いた肝臓再生修復療法の開発について

    寺井 崇二, 高見 太郎, 坂井田 功

    肝臓   51 ( Suppl.2 )   A450 - A450   2010.9

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  • メダカNASHモデルを用いた薬物スクリーニングについて

    寺井 崇二, 大石 俊之, 桑代 紳哉, 松本 俊彦, 坂井田 功

    肥満研究   16 ( Suppl. )   144 - 144   2010.9

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  • 肝胆膵疾患と組織幹細胞/progenitor cell 病態解析と治療戦略 Oval cellの活性化に伴う肝再生・修復過程におけるHGF/c-Metシグナリングの役割

    石川 剛, 寺井 崇二, 坂井田 功

    肝臓   51 ( Suppl.2 )   A511 - A511   2010.9

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  • 門脈圧亢進症に対するPSEと脾摘の有用性 部分的脾動脈塞栓術における血小板増加予測因子と肝予備能改善効果

    石川 剛, 浜辺 功一, 大森 薫, 高見 太郎, 瀬川 誠, 寺井 崇二, 山崎 隆弘, 坂井田 功

    日本門脈圧亢進症学会雑誌   16 ( 2 )   69 - 69   2010.8

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  • 食道・胃静脈瘤の予防的治療 バルーン閉塞下逆行性経静脈的塞栓術の肝機能改善効果

    石川 剛, 浜辺 功一, 大森 薫, 高見 太郎, 瀬川 誠, 寺井 崇二, 山崎 隆弘, 坂井田 功

    日本門脈圧亢進症学会雑誌   16 ( 2 )   57 - 57   2010.8

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  • バルーン閉塞下逆行性経静脈的塞栓術(B-RTO)前後での食道静脈瘤増悪の有無別の検討

    浜辺 功一, 瀬川 誠, 石川 剛, 寺井 崇二, 山崎 隆弘, 坂井田 功

    日本門脈圧亢進症学会雑誌   16 ( 2 )   97 - 97   2010.8

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  • 門脈圧亢進症の血行動態 門脈圧亢進症における病態進行度の指標としての肝弾性値の有用性

    瀬川 誠, 浜辺 功一, 石川 剛, 寺井 崇二, 山崎 隆弘, 坂井田 功

    日本門脈圧亢進症学会雑誌   16 ( 2 )   50 - 50   2010.8

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  • Medaka as a model for human nonalcoholic steatohepatitis Reviewed

    Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida

    DISEASE MODELS & MECHANISMS   3 ( 7-8 )   431 - 440   2010.7

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    DOI: 10.1242/dmm.002311

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  • 【NASH】基礎的メカニズムの解明 ヒト類似のメダカ非アルコール性脂肪肝炎(NASH)モデルの開発

    寺井 崇二, 松本 俊彦, 大石 俊之, 桑代 紳哉, 坂井田 功

    The Lipid   21 ( 3 )   235 - 246   2010.7

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  • Effect of a late evening snack using branched-chain amino acid-enriched nutrients in patients undergoing hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma Reviewed

    Yohei Harima, Takahiro Yamasaki, Satoe Hamabe, Issei Saeki, Kohsuke Okita, Shuji Terai, Isao Sakaida

    HEPATOLOGY RESEARCH   40 ( 6 )   574 - 584   2010.6

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    DOI: 10.1111/j.1872-034X.2010.00665.x

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  • 肝細胞癌との鑑別に苦慮した悪性黒色腫肝転移の一例

    在津 潤一, 石川 剛, 播磨 陽平, 土屋 昌子, 高見 太郎, 山口 裕樹, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    山口医学   59 ( 3 )   146 - 146   2010.6

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  • 肝病態形成における酸化ストレスの意義 メダカNASHモデルの病態にERストレス、酸化ストレス及び炎症細胞浸潤が関わりテルミサルタンは脂肪酸酸化の増加によりその病態進展を抑制する

    桑代 紳哉, 寺井 崇二, 大石 俊之, 藤澤 浩一, 松本 俊彦, 坂井田 功

    肝臓   51 ( Suppl.1 )   A91 - A91   2010.4

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  • 肝弾性値と門脈圧との関連性についての検討

    瀬川 誠, 浜辺 功一, 石川 剛, 大森 薫, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   51 ( Suppl.1 )   A349 - A349   2010.4

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  • HGF/c-Metシグナリングはoval cell由来肝再生に必須である

    石川 剛, 寺井 崇二, 坂井田 功

    肝臓   51 ( Suppl.1 )   A257 - A257   2010.4

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  • Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka

    Negishi, T, Nagai, Y, Asaoka, Y, Ohno, M, Namae, M, Mitani, H, Sasaki, T, Shimizu, N, Terai, S, Sakaida, I, Kondoh, H, Katada, T, Furutani-Seiki, M, Nishina, H

    Hepatology   51 ( 3 )   1037 - 45   2010.3

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    UNLABELLED: During vertebrate embryogenesis, the liver develops at a precise location along the endodermal primitive gut tube because of signaling delivered by adjacent mesodermal tissues. Although several signaling molecules have been associated with liver formation, the molecular mechanism that regulates liver specification is still unclear. We previously performed a screen in medaka to isolate mutants with impaired liver development. The medaka hio mutants exhibit a profound (but transient) defect in liver specification that resembles the liver formation defect found in zebrafish prometheus (prt) mutants, whose mutation occurs in the wnt2bb gene. In addition to their liver abnormality, hio mutants lack pectoral fins and die after hatching. Positional cloning indicated that the hio mutation affects the raldh2 gene encoding retinaldehyde dehydrogenase type2 (RALDH2), the enzyme principally responsible for retinoic acid (RA) biosynthesis. Mutations of raldh2 in zebrafish preclude the development of pectoral fins. Interestingly, in hio mutants, expression of wnt2bb in the lateral plate mesoderm (LPM) directly adjacent to the liver-forming endoderm was completely lost. CONCLUSION: Ou

    DOI: 10.1002/hep.23387

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  • Retinoic Acid Signaling Positively Regulates Liver Specification by Inducing wnt2bb Gene Expression in Medaka Reviewed

    Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakajda, Hisato Kondoh, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina

    HEPATOLOGY   51 ( 3 )   1037 - 1045   2010.3

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    DOI: 10.1002/hep.23387

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  • 細胞操作技術の最前線(第7回) 細胞治療技術 肝硬変も治る時代へ、自己細胞で肝炎治療

    高見 太郎, 寺井 崇二, 坂井田 功

    Medical Bio   7 ( 2 )   54 - 57   2010.3

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  • HGF/c-Metシグナリングはoval cell由来肝再生に必須である

    石川 剛, 寺井 崇二, 坂井田 功

    日本消化器病学会雑誌   107 ( 臨増総会 )   A261 - A261   2010.3

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  • Fish model leads to new findings in liver disease Reviewed

    Shuji Terai

    HEPATOLOGY RESEARCH   40 ( 1 )   111 - 113   2010.1

  • 肝臓 肝疾患における再生治療・細胞療法の展望

    高見 太郎, 寺井 崇二, 坂井田 功

    Annual Review消化器   2010   201 - 206   2010.1

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  • An Improved Method for Cirrhosis Detection Using Liver's Ultrasound Images. Reviewed

    Yusuke Fujita, Yoshihiko Hamamoto, Makoto Segawa, Shuji Terai, Isao Sakaida

    20th International Conference on Pattern Recognition, ICPR 2010, Istanbul, Turkey, 23-26 August 2010   2294 - 2297   2010

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    DOI: 10.1109/ICPR.2010.561

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  • Autologous Bone Marrow Infusion Activates the Progenitor Cell Compartment in Patients With Advanced Liver Cirrhosis Reviewed

    Ja Kyung Kim, Young Nyun Park, Jin Seok Kim, Mi-Suk Park, Yong Han Paik, Jae-Yeon Seok, Yong Eun Chung, Hyun Ok Kim, Kyung Sik Kim, Sang Hoon Ahn, Do Young Kim, Myeong-Jin Kim, Kwan Sik Lee, Chae Yoon Chon, Soo Jeong Kim, Shuji Terai, Isao Sakaida, Kwang-Hyub Han

    CELL TRANSPLANTATION   19 ( 10 )   1237 - 1246   2010

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    DOI: 10.3727/096368910X506863

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  • 【幹細胞を用いた消化器再生医療の展望】肝硬変症は幹細胞再生医療で治せるか

    高見 太郎, 寺井 崇二, 坂井田 功

    分子消化器病   6 ( 4 )   359 - 364   2009.12

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  • Contrast enhanced ultrasonography (US) with Sonazoid^【○!R】 was effective for abscess drainage and follow up : a case report

    OMORI Kaoru, TANIMOTO Haruko, TERAI Shuji, YAMASAKI Takahiro, SAKAIDA Isao

    Kanzo   50 ( 11 )   657 - 664   2009.11

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    A 64-year-old man was referred to our hospital with high fever and right upper abdominal pain. Dynamic computed tomography (CT) scan revealed a 60&amp;times;40-mm abscess in the right lobe of the liver. B mode and color doppler ultrasonography (US) imaging of the abdomen could not depict the abscess as clearly as the CT. An 81-mm hypervascular lesion was observed in segment 5/6 during the early vascular image of contrast-enhanced US performed using Sonazoid&lt;sup&gt;&amp;reg;&lt;/sup&gt;. A 50.2&amp;times;39.7-mm defect, which was considered to represent necrosis and cavity of the abscess, was clearly depicted during the Kupffer image of imaging. Percutaneous transhepatic drainage of the abscess was performed safely under contrast-enhanced US guidance (during the Kupffer image of imaging). The size of the abscess and the clinical healing course were tracked using the Kupffer-image imaging data. This case suggests that contrast-enhanced US with Sonazoid&lt;sup&gt;&amp;reg;&lt;/sup&gt; is an excellent modality for treatment and follow-up of a liver abscess.&lt;br&gt;

    DOI: 10.2957/kanzo.50.657

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  • Sonazoid造影超音波検査が治療と評価に有用であった肝膿瘍の一例

    高見 太郎, 大森 薫, 谷本 治子, 土屋 昌子, 寺井 崇二, 山崎 隆弘, 坂井田 功

    超音波医学   36 ( 6 )   701 - 701   2009.11

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  • Sonazoid造影超音波検査が診断に有用であった肝細胞癌の一例

    土屋 昌子, 高見 太郎, 寺井 崇二, 山崎 隆弘, 坂井田 功

    超音波医学   36 ( 6 )   701 - 701   2009.11

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  • 肝硬変の対策 原因療法から合併症の対策 非代償性肝硬変症に対する自己骨髄細胞投与療法の現状と今後の展開

    高見 太郎, 寺井 崇二, 坂井田 功

    肝臓   50 ( Suppl.3 )   A626 - A626   2009.10

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  • 【NASH 非アルコール性脂肪肝炎治療の現状と課題】NASHの治療 瀉血療法の可能性

    寺井 崇二, 松本 俊彦, 坂井田 功

    治療学   43 ( 10 )   1107 - 1110   2009.10

  • NASH研究の最前線 メダカNASHモデルの特性を生かした薬物スクリーニングについて

    寺井 崇二, 松本 俊彦, 坂井田 功

    肝臓   50 ( Suppl.3 )   A606 - A606   2009.10

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  • 門脈圧亢進症に対する総合的なアプローチ B-RTOとPSE

    大森 薫, 浜辺 功一, 石川 剛, 瀬川 誠, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   50 ( Suppl.3 )   A721 - A721   2009.10

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  • Telmisartanの投与によるマクロファージ浸潤抑制を含めたNASHの改善効果検討

    桑代 紳哉, 寺井 崇二, 大石 俊之, 藤澤 浩一, 松本 俊彦, 坂井田 功

    肥満研究   15 ( Suppl. )   185 - 185   2009.9

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  • 肝癌発生・進展の分子機構と臨床への還元 HHM(Maid)の肝発癌の制御分子としての重要性について

    寺井 崇二, 藤澤 浩一, 高見 太郎, 山崎 隆弘, 坂井田 功

    肝臓   50 ( Suppl.1 )   A97 - A97   2009.4

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  • TelmisartanはメダカNASHモデルにおいてER stressを改善し炎症細胞浸潤を抑制し病態を改善する

    桑代 紳哉, 寺井 崇二, 大石 俊之, 藤澤 浩一, 松本 俊彦, 坂井田 功

    肝臓   50 ( Suppl.1 )   A384 - A384   2009.4

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  • Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: Is the addition of subcutaneous interferon-alpha-2b beneficial? Reviewed

    Satoe Takaki-Hamabe, Takahiro Yamasaki, Issei Saeki, Yohei Harima, Kohsuke Okita, Shuji Terai, Isao Sakaida

    HEPATOLOGY RESEARCH   39 ( 3 )   223 - 230   2009.3

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    DOI: 10.1111/j.1872-034X.2008.00458.x

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  • Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells Reviewed

    Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanobori, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, Hiroshi Nishina

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   379 ( 4 )   817 - 823   2009.2

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    DOI: 10.1016/j.bbrc.2008.12.149

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  • On a diagnostic imaging teaching system for endoscopic education Reviewed

    K. Ogashiwa, Y. Hamamoto, Y. Fujita, K. Murokawa, H. Yoneda, M. Saito, S. Terai, I. Sakaida

    Proceedings of 1st Asia Pacific Conference on Health Promotion and Education   2009.1

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  • Continuos intravenous infusion of atrial natriuretic peptide(ANP) prevented liver fibrosis in rat Reviewed

    Noriko Ishigaki, Naold Yamamoto, Haiyan Jin, Kouichi Uchida, Shuji Terai, Isao Sakaida

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   378 ( 3 )   354 - 359   2009.1

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    DOI: 10.1016/j.bbrc.2008.10.154

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  • Current Status and Future Perspective for Autologous Bone Marrow Cell Infusion Therapy for Liver Cirrhosis Patients

    Terai Shuji, Sakaida Isao

    Nihon Ika Daigaku Igakkai Zasshi   5 ( 1 )   27 - 32   2009

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    DOI: 10.1272/manms.5.27

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  • Current status of autologous bone marrow cell infusion therapy for liver cirrhosis patients Reviewed

    Shuji Terai, Isao Sakaida

    HEPATOLOGY RESEARCH   38   S72 - S75   2008.11

  • Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma Reviewed

    Michihisa Iida, Norio Iizuka, Isao Sakaida, Toyoki Moribe, Nozomi Fujita, Toshiaki Miura, Shigeru Tamatsukuri, Hideo Ishitsuka, Koichi Uchida, Shuji Terai, Yoshihiro Tokuhisa, Kazuhiko Sakamoto, Takao Tamesa, Takanobu Miyamoto, Yoshihiko Hamamoto, Masaaki Oka

    ONCOLOGY REPORTS   20 ( 4 )   761 - 765   2008.10

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    DOI: 10.3892/or_00000071

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  • 消化器疾患の分子遺伝学的病態 HGF/c-Met signalingによるredox homeostasisの維持が肝発癌増殖を抑制する

    高見 太郎, 寺井 崇二, 坂井田 功

    日本消化器病学会雑誌   105 ( 臨増大会 )   A672 - A672   2008.9

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  • Hepatocyte growth factor/c-met signaling pathwayの欠損はDEN誘発肝発癌早期段階を促進させる(Loss of hepatocyte growth factor/c-met signaling pathway accelerates early stages of DEN-induced hepatocarcinogenesis)

    高見 太郎, 内田 耕一, 寺井 崇二, 坂井田 功

    日本癌学会総会記事   67回   179 - 179   2008.9

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  • 生活習慣病合併肝癌患者におけるHeat shock proteinおよび小胞体ストレス関連分子の発現の検討

    大石 俊之, 寺井 崇二, 桑代 紳哉, 松本 俊彦, 坂井田 功

    肥満研究   14 ( Suppl. )   202 - 202   2008.9

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  • メダカNASHモデルを用いた治療剤開発のストラテジー

    寺井 崇二, 桑代 紳哉, 大石 俊之, 松本 俊彦, 坂井田 功

    肥満研究   14 ( Suppl. )   189 - 189   2008.9

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  • メダカNASHモデルを用いたTelmisartanの効果検討

    桑代 紳哉, 寺井 崇二, 大石 俊之, 松本 俊彦, 坂井田 功

    肥満研究   14 ( Suppl. )   235 - 235   2008.9

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  • Pilot study of combination therapy with transcatheter arterial infusion chemotherapy using iodized oil and percutaneous radiofrequency ablation during occlusion of hepatic blood flow for hepatocellular carcinoma Reviewed

    Ryt Shiraishi, Takahiro Yamasaki, Issei Saeki, Kohsuke Ok-Ita, Ytthki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Salfaida

    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS   31 ( 4 )   311 - 316   2008.8

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    DOI: 10.1097/COC.0b013e31815e4539

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  • c-Metシグナル伝達経路はredox制御機構の安定化から肝発癌増殖抑制作用を有する

    高見 太郎, 内田 耕一, 寺井 崇二, 坂井田 功

    G.I.Research   16 ( 4 )   372 - 373   2008.8

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  • 肝の発癌と進展における分子代謝学的研究 Hepatocyte growth factor(HGF)/c-met signaling pathwayの肝発癌機構における意義

    高見 太郎, 内田 耕一, 寺井 崇二, 坂井田 功

    肝臓   49 ( Suppl.1 )   A44 - A44   2008.4

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  • 非アルコール性脂肪性肝疾患の病態と治療 メダカモデルから人へ NASH治療剤の開発の新ストラテジー

    寺井 崇二, 松本 俊彦, 坂井田 功

    肝臓   49 ( Suppl.1 )   A36 - A36   2008.4

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  • Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues Reviewed

    Yuichiro Yokoyama, Yasuhiro Kuramitsu, Motonari Takashima, Masanori Fujimoto, Norio Iizuka, Shuji Terai, Kiwamu Okita, Isao Sakaida, Masaaki Oka, Deborah A. Raynes, Vince Guerriero, Kazuyuki Nakamura

    MOLECULAR MEDICINE REPORTS   1 ( 2 )   197 - 201   2008.3

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  • Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver Reviewed

    Yoshio Marumoto, Shuji Tera, Yohei Urata, Toshihiko Matsumoto, Yuko Mizunaga, Naoki Yamamoto, Haiyan Jina, Koichi Fujisawa, Tomoaki Murata, Koh Shinoda, Hiroshi Nishina, Isao Sakaida

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   367 ( 3 )   546 - 552   2008.3

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    DOI: 10.1016/j.bbrc.2007.12.171

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  • A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder Reviewed

    Yumiko Isobe-Harima, Shuji Terai, Izumi Miura, Makoto Segawa, Tomoaki Murata, Kazuhito Itamoto, Yasuho Taura, Koh Shinoda, Isao Sakaida

    LIVER INTERNATIONAL   28 ( 1 )   117 - 125   2008.1

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    DOI: 10.1111/j.1478-3231.2007.01589.x

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  • Serum S100b (astrocyte-specific protein) is a useful marker of hepatic encephalopathy in patients with fulminant hepatitis Reviewed

    Yumiko Isobe-Harima, Shuji Terai, Makoto Segawa, Koichi Uchida, Takahiro Yamasaki, Isao Sakaida

    LIVER INTERNATIONAL   28 ( 1 )   146 - 147   2008.1

  • Transient elastography (FibroScan) is useful to diagnose the existence of esophageal varices

    Segawa M, Terai S, Yamasaki T, Sakaida I

    Japanese Journal of Portal Hypertension   14 ( 4 )   313 - 316   2008

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    DOI: 10.11423/jsph1999.14.4_313

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  • Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet Reviewed

    Haiyan Jin, Naoki Yamamoto, Koichi Uchida, Shuji Terai, Isao Sakaida

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   364 ( 4 )   801 - 807   2007.12

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    DOI: 10.1016/j.bbrc.2007.10.083

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  • 強皮症に肝細胞癌と乳癌を合併した一例

    佐伯 一成, 是永 匡紹, 岩本 拓也, 松本 俊彦, 瀬川 誠, 山口 裕樹, 是永 圭子, 内田 耕一, 寺井 崇二, 山崎 隆弘, 為佐 卓夫, 岡 正朗, 坂井田 功

    肝臓   48 ( Suppl3 )   A622 - A622   2007.11

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  • NASHにおける肝線維化と発癌をめぐって 耐糖能異常は脂肪肝症例における肝線維化・発癌のリスクファクターの可能性がある

    松本 俊彦, 寺井 崇二, 坂井田 功

    肝臓   48 ( Suppl3 )   A514 - A514   2007.11

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  • The development of new drug screening system using steatohepatitis medaka fish model induced by high-fat diet Reviewed

    Matsumoto Toshihiko, Terai Shuji, Kuwashiro Shinya, Fujisawa Koichi, Yamamoto Naoki, Hamamoto Yoshihiko, Sakaida Isao

    HEPATOLOGY   46 ( 4 )   756A   2007.10

  • Is an arterial infusion chemotherapy with pegylated interferon-alpha-2b effective for advanced hepatocellular carcinoma? Reviewed

    Yamasaki Takahiro, Saeki Issei, Okita Kousuke, Yamaguchi Yuhki, Uchida Koichi, Terai Shuji, Sakaida Isao

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22   A193   2007.10

  • 肝の再生医学・医療/人工肝臓の現状と展望 肝硬変症に対する自己骨髄細胞投与療法(ABMI療法)の現状および今後の工夫について

    寺井 崇二, 丸本 芳雄, 坂井田 功

    肝臓   48 ( Suppl.2 )   A357 - A357   2007.9

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  • メダカNASHモデルにおける病態解析

    松本 俊彦, 寺井 崇二, 坂井田 功

    肝臓   48 ( Suppl.2 )   A474 - A474   2007.9

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  • Importance of inhibitor of DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation Reviewed

    Kunihiko Tajima, Shuji Terai, Taro Takami, Kotaro Kawaguchi, Kiwamu Okita, Isao Sakaida

    HEPATOLOGY RESEARCH   37 ( 8 )   647 - 655   2007.8

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    DOI: 10.1111/j.1872-034X.2007.00089.x

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  • The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis Reviewed

    Haiyan Jin, Shuii Terai, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY   42 ( 6 )   475 - 484   2007.6

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    DOI: 10.1007/s00535-007-2020-5

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  • [Candidate drugs for non-alcoholic steatohepatitis (NASH)]. Reviewed

    Terai S, Matsumoto T, Sakaida I

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica   129 ( 4 )   271 - 275   2007.4

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    DOI: 10.1254/fpj.129.271

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  • 治療薬シリーズ 高脂血症 非アルコール性脂肪性肝疾患、肝炎に対する薬物療法について

    寺井 崇二, 松本 俊彦, 坂井田 功

    日本薬理学雑誌   129 ( 4 )   271 - 275   2007.4

  • Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice Reviewed

    Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Tomoaki Murata, Yuko Mizunaga, Naoki Yamamoto, Hiroshi Nishina, Koh Shinoda, Isao Sakaida

    CELL AND TISSUE RESEARCH   327 ( 3 )   463 - 470   2007.3

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    DOI: 10.1007/s00441-006-0334-x

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  • Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma Reviewed

    Tokuhisa, Y., Iizuka, N., Sakaida, I., Moribe, T., Fujita, N., Miura, T., Tamatsukuri, S., Ishitsuka, H., Uchida, K., Terai, S., Sakamoto, K., Tamesa, T., Oka, M.

    British Journal of Cancer   97 ( 10 )   1399 - 1403   2007

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    DOI: 10.1038/sj.bjc.6604034

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  • Elevated levels of circulating cell-free DNA in the blood of patients with hepatitis C virus-associated hepatocellular carcinoma Reviewed

    Norio Iizuka, Isao Sakaida, Toyoki Moribe, Nozomi Fujita, Toshiaki Miura, Markus Stark, Shigeru Tamatsukuri, Hideo Ishitsuka, Koichi Uchida, Shuji Terai, Kazuhiko Sakamoto, Takao Tamesa, Masaaki Oka

    ANTICANCER RESEARCH   26 ( 6C )   4713 - 4719   2006.11

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  • Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy Reviewed

    Shuji Terai, Tsuyoshi Ishikawa, Kaoru Omori, Koji Aoyama, Yoshio Marumoto, Yohei Urata, Yuichirou Yokoyama, Koichi Uchida, Takahiro Yamasaki, Yasuhiko Fujii, Kiwamu Okita, Isao Sakaida

    STEM CELLS   24 ( 10 )   2292 - 2298   2006.10

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    DOI: 10.1634/stemcells.2005-0542

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  • 【消化器疾患 state of arts II.肝・胆・膵】治療法をめぐる最近の進歩 肝再生医療の現況と展望 細胞療法を用いた肝再生医療 自己骨髄細胞を用いた肝再生療法の開発

    丸本 芳雄, 寺井 崇二, 坂井田 功

    医学のあゆみ   別冊 ( 消化器疾患Ver.3 )   495 - 498   2006.10

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  • rFGF2併用骨髄移植の肝線維化改善効果とその分子制御機構

    石川 剛, 寺井 崇二, 坂井田 功

    肝臓   47 ( Suppl.2 )   A477 - A477   2006.9

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  • 消化器疾患の再生医療 自己骨髄細胞を用いた肝臓再生療法の現状と今後の展開

    寺井 崇二, 石川 剛, 坂井田 功

    日本消化器病学会雑誌   103 ( 臨増大会 )   A413 - A413   2006.9

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  • Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation Reviewed

    Y Yokoyama, S Terai, T Ishikawa, K Aoyama, Y Urata, Y Marumoto, N Hiroshi, K Nakamura, K Okita, Sakaida, I

    PROTEOMICS   6 ( 8 )   2564 - 2570   2006.4

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    DOI: 10.1002/pmic.200500018

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  • XBP-1は骨髄細胞から肝細胞への分化に関与する

    丸本 芳雄, 寺井 崇二, 水永 裕子, 松本 俊彦, 浦田 洋平, 青山 浩司, 石川 剛, 坂井田 功

    肝臓   47 ( Suppl.1 )   A292 - A292   2006.4

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  • メダカを用いた新規脂肪肝モデルの作成と,脂肪肝形成過程における遺伝子発現の検討

    松本 俊彦, 寺井 崇二, 丸本 芳雄, 仁科 博史, 坂井田 功

    肝臓   47 ( Suppl.1 )   A97 - A97   2006.4

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  • 肝線維化の分子機構と治療 rFGF2併用骨髄移植の肝線維化改善効果とその分子制御機構

    石川 剛, 寺井 崇二, 坂井田 功

    肝臓   47 ( Suppl.1 )   A41 - A41   2006.4

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  • Protein level of apolipoprotein E increased in human hepatocellular carcinoma Reviewed

    Y Yokoyama, Y Kuramitsu, M Takashima, N Iizuka, S Terai, M Oka, K Nakamura, K Okita, Sakaida, I

    INTERNATIONAL JOURNAL OF ONCOLOGY   28 ( 3 )   625 - 631   2006.3

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  • 炎症と発癌 肝持続炎症環境下における小胞体ストレス関連分子XBP-1とHSPの発現についての解析

    丸本 芳雄, 寺井 崇二, 坂井田 功

    日本消化器病学会雑誌   103 ( 臨増総会 )   A127 - A127   2006.3

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  • Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes Reviewed

    T Ishikawa, S Terai, Y Urata, Y Marumoto, K Aoyama, Sakaida, I, T Murata, H Nishina, K Shinoda, S Uchimura, Y Hamamoto, K Okita

    CELL AND TISSUE RESEARCH   323 ( 2 )   221 - 231   2006.2

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    DOI: 10.1007/s00441-005-0077-0

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  • 【ここまで進んだ幹細胞研究と再生医療2006 幹細胞の分化を運命づけるメカニズムから臨床応用の取り組み,産業化の展望まで】幹細胞の臨床応用 ここまで来ている再生医療 自己骨髄細胞を用いた肝臓再生療法の開発 基礎研究から臨床研究へ

    石川 剛, 寺井 崇二, 坂井田 功

    実験医学   24 ( 2 )   268 - 273   2006.1

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  • 脂肪肝に対するイコサペント酸エチル(エパデールS)の有用性の検討

    松本 俊彦, 寺井 崇二, 坂井田 功

    肝臓   46 ( Suppl.3 )   A562 - A562   2005.11

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  • 急性肝不全における肝再生療法の現状 rFGF2併用骨髄移植による肝障害改善効果とその分子制御機構

    石川 剛, 寺井 崇二, 坂井田 功, 沖田 極

    肝臓   46 ( 11 )   678 - 678   2005.11

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  • 肝病変進展抑制をめざす新しい視点 基礎と臨床 rFGF2併用骨髄移植による肝病変改善効果とその分子制御機構

    石川 剛, 寺井 崇二, 沖田 極

    日本消化器病学会雑誌   102 ( 臨増大会 )   A574 - A574   2005.9

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  • 肝病変進展抑制をめざす新しい視点 基礎と臨床 rFGF2併用骨髄移植による肝病変改善効果とその分子制御機構

    石川 剛, 寺井 崇二, 沖田 極

    肝臓   46 ( Suppl.2 )   A374 - A374   2005.9

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  • Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells Reviewed

    JH Shen, Sakaida, I, K Uchida, S Terai, K Okita

    LIFE SCIENCES   77 ( 13 )   1502 - 1515   2005.8

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    DOI: 10.1016/j.lfs.2005.04.004

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  • Human homologue of maid is a useful marker protein in hepatocarcinogenesis Reviewed

    T Takami, S Terai, Y Yokoyama, H Tanimoto, K Tajima, K Uchida, T Yamasaki, Sakaida, I, H Nishina, SS Thorgeirsson, K Okita

    GASTROENTEROLOGY   128 ( 5 )   1369 - 1380   2005.5

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    DOI: 10.1053/j.gastro.2005.03.014

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  • レトロウイルスベクターを用いたId2持続強制発現HSc-T6での線維化抑制の検討

    田島 邦彦, 寺井 崇二, 金 海燕, 磯部 夕美子, 松本 俊彦, 浦田 洋平, 丸本 芳雄, 川口 浩太郎, 高見 太郎, 土屋 昌子, 内田 耕一, 坂井田 功, 沖田 極

    肝臓   46 ( Suppl.1 )   A68 - A68   2005.5

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  • 骨髄細胞から肝細胞への分化過程における線維芽細胞増殖因子の促進効果

    石川 剛, 寺井 崇二, 磯部 夕美子, 松本 俊彦, 浦田 洋平, 丸本 芳雄, 青山 浩司, 大森 薫, 坂井田 功, 沖田 極

    肝臓   46 ( Suppl.1 )   A157 - A157   2005.5

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  • Liv-8陰性分画骨髄細胞移植による肝線維化改善時における,ECM関連遺伝子群の経時的発現変化の検討

    青山 浩司, 坂井田 功, 磯部 夕美子, 松本 俊彦, 浦田 洋平, 丸本 芳雄, 石川 剛, 大森 薫, 寺井 崇二, 沖田 極

    肝臓   46 ( Suppl.1 )   A71 - A71   2005.5

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  • PCR-selected cDNA subtractionシステムを用いた骨髄細胞から肝細胞への分化制御遺伝子の検索

    丸本 芳雄, 寺井 崇二, 松本 俊彦, 浦田 洋平, 青山 浩司, 石川 剛, 大森 薫, 坂井田 功, 仁科 博史, 沖田 極

    肝臓   46 ( Suppl.1 )   A101 - A101   2005.5

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  • 臨床研究(自己骨髄細胞を用いた肝臓再生療法)の途中経過と頻回骨髄細胞の投与法への工夫

    寺井 崇二, 大森 薫, 石川 剛, 青山 浩司, 浦田 洋平, 丸本 芳雄, 坂井田 功, 沖田 極

    肝臓   46 ( Suppl.1 )   A57 - A57   2005.5

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  • 骨髄幹細胞移植による肝疾患の治療

    沖田 極, 寺井 崇二, 坂井田 功

    日本内科学会雑誌   94 ( 4 )   769 - 774   2005.4

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    骨髄には造血幹細胞が存在し白血病患者に対する骨髄移植によって患者の体内で一生に渡り血球細胞を供給することが可能である.骨髄移植は既に20年以上の実績を積んだ体性幹細胞を用いた再生医療である.最近になり男女間での骨髄移植の結果,骨髄由来の肝細胞,小腸細胞への分化が確認され,骨髄中に多分化能を持つ"骨髄由来幹細胞"の存在が考えられるようになった.すでに循環器領域では虚血性疾患に対して臨床応用として血管新生を誘導するために自己の骨髄細胞を患部に自家移植する試みがすでに行われてきた.我々は自己骨髄細胞を用いた肝臓再生療法を開発するため,どんな状況で骨髄細胞移植が有効であるかを検討し,持続肝障害が続く状態において骨髄細胞が肝再生誘導,肝線維化制御に役立つことを見出した.さらにそれらの基礎研究の結果を基盤とし,国内最初の臨床研究:自己骨髄細胞を用いた肝臓再生療法のPhasel研究を平成15年11月より開始し現在進行中である.

    DOI: 10.2169/naika.94.769

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  • Use of bone marrow cells for the development of cellular therapy in liver diseases Reviewed

    Sakaida, I, S Terai, K Okita

    HEPATOLOGY RESEARCH   31 ( 4 )   195 - 196   2005.4

  • Treatment of hepatic diseases with bone marrow stem cell transplantation Reviewed

    Okita, K., Terai, S., Sakaida, I.

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   94 ( 4 )   769 - 774   2005.4

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  • 消化器領域における細胞増殖因子と組織再生療法を目指したニューフロンティア 基礎から臨床へ 骨髄細胞から肝細胞への分化過程における線維芽細胞増殖因子の促進効果

    石川 剛, 寺井 崇二, 沖田 極

    日本消化器病学会雑誌   102 ( 臨増総会 )   A156 - A156   2005.3

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  • Percutaneous radiofrequency ablation with cooled electrodes combined with hepatic arterial balloon occlusion in hepatocellular carcinoma Reviewed

    T Yamasaki, T Kimura, F Kurokawa, KJ Aoyama, T Ishikawa, K Tajima, Y Yokoyama, T Takami, K Omori, K Kawaguchi, M Tsuchiya, S Terai, Sakaida, I, K Okita

    JOURNAL OF GASTROENTEROLOGY   40 ( 2 )   171 - 178   2005.2

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    DOI: 10.1007/s00535-004-15L6-5

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  • Prognostic factors in patients with advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy Reviewed

    T Yamasaki, T Kimura, F Kurokawa, K Aoyama, T Ishikawa, K Tajima, Y Yokoyama, T Takami, K Omori, K Kawaguchi, M Tsuchiya, S Terai, Sakaida, I, K Okita

    JOURNAL OF GASTROENTEROLOGY   40 ( 1 )   70 - 78   2005.1

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    DOI: 10.1007/s00535-004-1494-7

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  • Development of New Therapy in Fulminant Hepatitis from Glucagon-Insulin Therapy to Bone Marrow Cell Transplantation

    Kiwamu Okita, Isao Sakaida, Shuji Terai, Naoki Yamamoto, Kaoru Omori, Tsuyoshi Ishikawa, Kouji Aoyama, Koh Shinoda, Yoshihiko Hamamoto

    THE BULLETIN OF THE YAMAGUCHI MEDICAL SCHOOL   52 ( 3-4 )   25 - 31   2005

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  • Development of cell therapy using autologous bone marrow cells for liver cirrhosis Reviewed

    Isao Sakaida, Shuji Terai, Hiroshi Nishina, Kiwamu Okita

    Medical Molecular Morphology   38 ( 4 )   197 - 202   2005

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    DOI: 10.1007/s00795-005-0298-z

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  • Lesson from the GFP/CCl4 model - Translational Research Project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis Reviewed

    S Terai, Sakaida, I, H Nishina, K Okita

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY   12 ( 3 )   203 - 207   2005

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    DOI: 10.1007/s00534-005-0977-0

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  • Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression Reviewed

    K Omori, S Terai, T Ishikawa, K Aoyama, Sakaida, I, H Nishina, K Shinoda, S Uchimura, Y Hamamoto, K Okita

    FEBS LETTERS   578 ( 1-2 )   10 - 20   2004.12

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    DOI: 10.1016/j.febslet.2004.09.090

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  • Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice Reviewed

    Sakaida, I, S Terai, N Yamamoto, K Aoyama, T Ishikawa, H Nishina, K Okita

    HEPATOLOGY   40 ( 6 )   1304 - 1311   2004.12

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    DOI: 10.1002/hep.20452

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  • 自己骨髄細胞を用いた肝硬変症に対する肝臓再生療法

    寺井 崇二, 大森 薫, 石川 剛, 青山 浩司, 高見 太郎, 横山 雄一郎, 田島 邦彦, 坂井田 功, 沖田 極

    治療学   38 ( 10 )   1158 - 1159   2004.10

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  • 肝発癌機構におけるhelix-loop-helix(HLH)型転写制御分子の発現とその制御

    高見 太郎, 寺井 崇二, 沖田 極

    肝臓   45 ( Suppl.2 )   A486 - A486   2004.9

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  • 骨髄細胞の肝細胞への分化過程において変動する血清蛋白質の解析

    横山 雄一郎, 寺井 崇二, 大森 薫, 青山 浩司, 石川 剛, 高見 太郎, 坂井田 功, 沖田 極

    日本癌学会総会記事   63回   505 - 506   2004.9

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  • 肝発癌早期に高発現するHHM(Human Homologue of Maid)のプロモーター解析と,肝疾患患者血清中の抗HHM抗体の検出

    高見 太郎, 寺井 崇二, 横山 雄一郎, 田島 邦彦, 谷本 治子, 仁科 博史, 坂井田 功, 沖田 極

    日本癌学会総会記事   63回   295 - 295   2004.9

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  • 肝細胞癌に対する新しいバルーンマイクロカテーテルを用いたリピオドール併用肝動脈バルーン閉塞下ラジオ波凝固療法

    山崎 隆弘, 木村 輝昭, 浦田 洋平, 丸本 芳雄, 青山 浩司, 石川 剛, 田島 邦彦, 横山 雄一郎, 大森 薫, 川口 浩太郎, 高見 太郎, 土屋 昌子, 山口 裕樹, 寺井 崇二, 黒川 典枝, 坂井田 功, 沖田 極

    肝臓   45 ( 9 )   505 - 506   2004.9

  • 骨髄細胞から肝細胞への分化転換における線維芽細胞増殖因子の関与

    石川 剛, 寺井 崇二, 浦田 洋平, 丸本 芳雄, 青山 浩司, 大森 薫, 坂井田 功, 沖田 極

    肝臓   45 ( Suppl.2 )   A509 - A509   2004.9

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  • Proteomic profiling of proteins decreased in hepatocellular carcinoma from patients infected with hepatitis C virus Reviewed

    Y Yokoyama, Y Kuramitsu, M Takashima, N Iizuka, T Toda, S Terai, Sakaida, I, M Oka, K Nakamura, K Okita

    PROTEOMICS   4 ( 7 )   2111 - 2116   2004.7

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  • Helix-loop-helix(HLH)型転写制御分子Human homologue of Maid(HHM)からみた肝発癌

    高見 太郎, 寺井 崇二, 谷本 治子, 坂井田 功, 沖田 極

    山口医学   53 ( 3 )   185 - 185   2004.6

  • 肝発癌におけるHuman homologue of Maid(HHM)の機能とその発現制御

    高見 太郎, 寺井 崇二, 沖田 極

    肝臓   45 ( Suppl.1 )   A96 - A96   2004.4

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  • 肝硬変患者の就寝前肝不全経口栄養剤投与についての検討

    土屋 昌子, 坂井田 功, 青山 浩司, 石川 剛, 田島 邦彦, 横山 雄一郎, 大森 薫, 川口 浩太郎, 高見 太郎, 木村 輝昭, 寺井 崇二, 山崎 隆弘, 黒川 典枝, 沖田 極

    肝臓   45 ( Suppl.1 )   A258 - A258   2004.4

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  • 骨髄細胞による肝再生モデルマウスにおける血清プロテオミクス

    横山 雄一郎, 寺井 崇二, 大森 薫, 青山 浩司, 石川 剛, 高見 太郎, 坂井田 功, 沖田 極

    肝臓   45 ( Suppl.1 )   A225 - A225   2004.4

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  • 骨髄細胞移植による肝線維化治療の検討

    坂井田 功, 山 浩司, 石川 剛, 大森 薫, 寺井 崇二, 仁科 博史, 沖田 極

    マトリックス研究会大会   ( 51 )   52 - 52   2004.4

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  • 【幹細胞と消化器疾患】骨髄細胞から肝細胞への分化転換の制御機構の解析とその臨床応用 自己骨髄細胞を用いた肝臓再生療法の基礎的検討

    寺井 崇二, 石川 剛, 大森 薫, 青山 浩司, 坂井田 功, 沖田 極

    G.I.Research   12 ( 2 )   117 - 125   2004.4

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  • 線維芽細胞増殖因子は骨髄細胞から肝細胞への分化転換を促進する

    石川 剛, 寺井 崇二, 浦田 洋平, 丸本 芳雄, 青山 浩司, 大森 薫, 坂井田 功, 沖田 極

    肝臓   45 ( Suppl.1 )   A43 - A43   2004.4

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  • 骨髄細胞から肝細胞への分化転換の素過程に関与する遺伝子群の抽出及び可視化

    大森 薫, 寺井 崇二, 浦田 洋平, 丸本 芳雄, 石川 剛, 青山 浩司, 坂井田 功, 仁科 博史, 内村 俊二, 浜本 義彦, 沖田 極

    肝臓   45 ( Suppl.1 )   A84 - A84   2004.4

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  • Liv-8陰性分画骨髄細胞の移植による肝線維化改善の検討

    青山 浩司, 坂井田 功, 浦田 洋平, 丸本 芳雄, 石川 剛, 大森 薫, 寺井 崇二, 沖田 極

    肝臓   45 ( Suppl.1 )   A89 - A89   2004.4

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  • Herbal medicine Sho-saiko-to (TJ-9) increases expression matrix metalloproteinases (MMPs) with reduced expression of tissue inhibitor of metalloproteinases (TIMPs) in rat stellate cell Reviewed

    Sakaida, I, K Hironaka, T Kimura, S Terai, T Yamasaki, K Okita

    LIFE SCIENCES   74 ( 18 )   2251 - 2263   2004.3

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    DOI: 10.1016/j.lfs.2003.09.059

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  • A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver Reviewed

    N Yamamoto, S Terai, S Ohata, T Watanabe, K Omori, K Shinoda, K Miyamoto, T Katada, Sakaida, I, H Nishina, K Okita

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   313 ( 4 )   1110 - 1118   2004.1

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    DOI: 10.1016/j.bbrc.2003.12.044

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  • 肝臓 肝細胞癌の病態と診断

    高見 太郎, 寺井 崇二, 沖田 極

    Annual Review消化器   2004   303 - 307   2004.1

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  • Strategy for the development of cell therapy using bone marrow cells to repair damaged liver Reviewed

    S Terai, Sakaida, I, N Yamamoto, K Omori, K Okita

    STEM CELL AND LIVER REGENERATION   51 - 56   2004

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  • An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes Reviewed

    S Terai, Sakaida, I, N Yamamoto, K Omori, T Watanabe, S Ohata, T Katada, K Miyamoto, K Shinoda, H Nishina, K Okita

    JOURNAL OF BIOCHEMISTRY   134 ( 4 )   551 - 558   2003.10

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  • Arterial infusion chemotherapy using cisplatin, 5-fluorouracil, and isovorin for patients with advanced hepatocellular carcinoma, pilot study: Is a high dose of the biochemical modulator effective? Reviewed

    T Yamasaki, F Kurokawa, T Takami, K Omori, K Kawaguchi, M Tsuchiya, N Yamamoto, M Okamoto, K Hironaka, T Kimura, S Terai, Sakaida, I, K Okita

    HEPATOLOGY RESEARCH   27 ( 1 )   36 - 44   2003.9

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    DOI: 10.1016/S1386-6346(03)00195-5

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  • Leptin receptor-deficient Zucker (fa/fa) rat retards the development of pig serum-induced liver fibrosis with Kupffer cell dysfunction Reviewed

    Sakaida, I, S Jinhua, K Uchida, S Terai, K Okita

    LIFE SCIENCES   73 ( 19 )   2491 - 2501   2003.9

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    DOI: 10.1016/S0024-3205(03)00653-2

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  • 【コンセンサス肝細胞癌の治療】肝細胞癌治療後のフォローアップと補助療法

    山崎 隆弘, 高見 太郎, 大森 薫, 川口 浩太郎, 土屋 昌子, 木村 輝昭, 寺井 崇二, 黒川 典枝, 坂井田 功, 沖田 極

    コンセンサス癌治療   2 ( 3 )   162 - 163   2003.8

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  • 肝臓の発生分化再生過程におけるHLH型転写制御分子の解析

    谷本 治子, 寺井 崇二, 高見 太郎, 横山 雄一郎, 田島 邦彦, 仁科 博史, 沖田 極

    日本癌学会総会記事   62回   324 - 324   2003.8

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  • HHM(Human Homologue of Maid)は肝発癌をinitiateする

    高見 太郎, 寺井 崇二, 横山 雄一郎, 田島 邦彦, 谷本 治子, 内田 耕一, 木村 輝昭, 宮本 康嗣, 黒川 典枝, 仁科 博史, 坂井田 功, 沖田 極

    日本癌学会総会記事   62回   284 - 284   2003.8

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  • Herbal medicine inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a cholinedeficient (L)-amino acid-defined diet Reviewed

    Sakaida, I, M Tsuchiya, K Kawaguchi, T Kimura, S Terai, K Okita

    JOURNAL OF HEPATOLOGY   38 ( 6 )   762 - 769   2003.6

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    DOI: 10.1016/S0168-8278(03)00094-1

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  • 【肝細胞癌の治療方針 最近の進歩】肝細胞癌に対する経皮的局所治療

    山崎 隆弘, 木村 輝昭, 高見 太郎, 大森 薫, 川口 浩太郎, 土屋 昌子, 山本 直樹, 岡本 真理子, 寺井 崇二, 黒川 典枝, 坂井田 功, 沖田 極

    消化器外科   26 ( 5 )   563 - 569   2003.5

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  • ラット肝星細胞のMAPKシグナル伝達経路におけるMMPsの制御

    土屋 昌子, 坂井田 功, 青山 浩司, 石川 剛, 田島 邦彦, 横山 雄一郎, 大森 薫, 川口 浩太郎, 高見 太郎, 寺井 崇二, 沖田 極

    肝臓   44 ( Suppl.1 )   A142 - A142   2003.4

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  • 骨髄細胞移植による肝繊維化治療の検討

    青山 浩司, 坂井田 功, 石川 剛, 田島 邦彦, 横山 雄一郎, 大森 薫, 川口 浩太郎, 高見 太郎, 土屋 昌子, 山本 直樹, 寺井 崇二, 沖田 極

    肝臓   44 ( Suppl.1 )   A103 - A103   2003.4

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  • Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells Reviewed

    Sakaida, I., Hironaka, K., Terai, S., Okita, K.

    Life Sciences   72 ( 8 )   943 - 959   2003

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    DOI: 10.1016/S0024-3205(02)02342-1

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  • 劇症肝炎時におけるアポトーシス誘導因子であるチトクロムc血清中濃度の臨床的検討について

    木村 輝昭, 坂井田 功, 大森 薫, 川口 浩太郎, 土屋 昌子, 高見 太郎, 岡本 真理子, 山本 直己, 坂口 栄樹, 瀬川 誠, 寺井 崇二, 萱野 幸三, 山崎 隆弘, 沖田 極

    肝臓   43 ( 12 )   600 - 601   2002.12

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  • Ubiquitin is a possible new predictive marker for the recurrence of human hepatocellular carcinoma Reviewed

    H Shirahashi, Sakaida, I, S Terai, K Hironaka, N Kusano, K Okita

    LIVER   22 ( 5 )   413 - 418   2002.10

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    DOI: 10.1034/j.1600-0676.2002.01541.x

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  • 骨髄細胞から肝細胞への分化制御に関する遺伝子群の検索

    大森 薫, 寺井 崇二, 山本 直樹, 川口 浩太郎, 高見 太郎, 土屋 昌子, 内田 耕一, 宮本 康嗣, 坂井田 功, 仁科 博史, 沖田 極

    日本消化吸収学会総会プログラム・講演抄録集   33回   107 - 107   2002.10

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  • 骨髄細胞を用いた肝臓再生療法の開発を目指して GFP/CCI4モデルの開発と解析及び骨髄中の幹細胞の同定法

    寺井 崇二, 山本 直樹, 大森 薫, 川口 浩太郎, 高見 太郎, 宮本 康嗣, 坂井田 功, 仁科 博史, 沖田 極

    日本癌学会総会記事   61回   464 - 465   2002.10

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  • 肝幹細胞の発生分化と肝発癌に関与するHLH型転写制御分子Human Homologue of Maid(HHM)

    高見 太郎, 寺井 崇二, 内田 耕一, 川口 浩太郎, 大森 薫, 土屋 昌子, 山本 直樹, 木村 輝昭, 黒川 典枝, 宮本 康嗣, 坂井田 功, 沖田 極

    日本癌学会総会記事   61回   78 - 78   2002.10

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  • 骨髄細胞から肝細胞への分化制御に関する遺伝子群の検索

    大森 薫, 寺井 崇二, 山本 直樹, 川口 浩太郎, 高見 太郎, 土屋 昌子, 内田 耕一, 宮本 康嗣, 坂井田 功, 仁科 博史, 沖田 極

    Gastroenterological Endoscopy   44 ( Suppl.2 )   1476 - 1476   2002.9

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  • 骨髄細胞から肝細胞への分化制御に関する遺伝子群の検索

    大森 薫, 寺井 崇二, 山本 直樹, 川口 浩太郎, 高見 太郎, 土屋 昌子, 内田 耕一, 宮本 康嗣, 坂井田 功, 仁科 博史, 沖田 極

    日本消化器集団検診学会雑誌   40 ( 5 )   106 - 106   2002.9

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  • Liv8抗体を用いた臨床応用可能な骨髄中の肝幹細胞群の同定への試み

    山本 直樹, 寺井 崇二, 大森 薫, 高見 太郎, 川口 浩太郎, 宮本 康嗣, 坂井田 功, 仁科 博史, 沖田 極

    肝臓   43 ( Suppl.2 )   A369 - A369   2002.9

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  • 骨髄細胞から肝細胞への分化制御に関する遺伝子群の検索

    大森 薫, 寺井 崇二, 山本 直樹, 川口 浩太郎, 高見 太郎, 土屋 昌子, 内田 耕一, 宮本 康嗣, 坂井田 功, 仁科 博史, 沖田 極

    肝臓   43 ( Suppl.2 )   A337 - A337   2002.9

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  • 肝細胞癌破裂における肝動脈塞栓術(TAE)の意義

    山本 直樹, 山崎 隆弘, 高見 太郎, 大森 薫, 川口 浩太郎, 木村 輝昭, 寺井 崇二, 黒川 典枝, 坂井田 功, 沖田 極

    山口医学   51 ( 3 )   89 - 90   2002.6

  • 星細胞活性化に伴う新規転写制御因子HHM(Human homologue of Maid)とMyoDの発現動態についての検討

    川口 浩太郎, 坂井田 功, 寺井 崇二, 高見 太郎, 大森 薫, 山本 直樹, 木村 輝昭, 萱野 幸三, 沖田 極

    肝臓   43 ( Suppl.1 )   A43 - A43   2002.5

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  • 【これからの肝発癌研究をどう考えるか】遺伝子「DNAチップを用いた遺伝子発現パターン」 肝発癌に関与する転写制御分子HHM

    寺井 崇二, 坂井田 功, 高見 太郎, 内田 耕一, 白橋 斉, 山本 直樹, 大森 薫, 川口 浩太郎, 宮本 康嗣, 沖田 極

    医学と薬学   47 ( Suppl. )   4 - 10   2002.5

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  • 新規マウスモノクローナル抗体Liv抗体群及びMaid抗体を用いた肝幹細胞同定への試み

    山本 直樹, 寺井 崇二, 大森 薫, 高見 太郎, 川口 浩太郎, 内田 耕一, 宮本 康嗣, 坂井田 功, 仁科 博史, 沖田 極

    肝臓   43 ( Suppl.1 )   A102 - A102   2002.5

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  • 骨髄細胞から肝細胞への分化制御に関する遺伝子群の検索

    大森 薫, 寺井 崇二, 山本 直樹, 川口 浩太郎, 高見 太郎, 内田 耕一, 宮本 康嗣, 坂井田 功, 仁科 博史, 沖田 極

    肝臓   43 ( Suppl.1 )   A100 - A100   2002.5

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  • 肝発癌に関与する転写制御分子HHMの機能解析

    高見 太郎, 寺井 崇二, 内田 耕一, 川口 浩太郎, 大森 薫, 山本 直樹, 瀬川 誠, 木村 輝昭, 萱野 幸三, 山崎 隆弘

    肝臓   43 ( Suppl.1 )   A35 - A35   2002.5

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  • HHM: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression and liver stem cells Reviewed

    S Terai, SS Thorgeirsson, K Okita

    GROWTH, PROLIFERATION, AND APOPTOSIS IN HEPATOCYTES   1 - 9   2002

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  • A new cell therapy using bone marrow cells to repair damaged liver Reviewed

    S Terai, N Yamamoto, K Omori, Sakaida, I, K Okita

    JOURNAL OF GASTROENTEROLOGY   37   162 - 163   2002

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  • Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet Reviewed

    Sakaida, I, T Yamasaki, S Terai, K Okita

    ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER MEETING 2002   153 - 158   2002

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  • 生体部分肝移植で救命し得たB型劇症肝炎急性型の成人例

    大森 薫, 木村 輝昭, 丸本 芳雄, 川口 浩太郎, 高見 太郎, 岡本 真理子, 瀬川 誠, 坂口 栄樹, 岡崎 宗子, 寺井 崇二

    山口医学   50 ( 6 )   829 - 829   2001.12

  • 近未来医療 移植から再生医療 GFP transgenic mouseを用いた肝臓再生療法の基礎的検討

    山本 直樹, 寺井 崇二, 坂井田 功, 大森 薫, 川口 浩太郎, 高見 太郎, 坂口 栄樹, 宮本 康嗣, 沖田 極

    肝臓   42 ( Suppl.3 )   A479 - A479   2001.11

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  • 肝細胞癌に対するバルーンマイクロカテーテルを用いた肝動脈バルーン閉塞下ラジオ波凝固療法

    山崎隆弘, 黒川典枝, 高見太郎, 山本直樹, 是永匡紹, 木村輝昭, 寺井崇二, 萱野幸三, 坂井田 功, 沖田 極

    肝臓   42   688 - 689   2001

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    DOI: 10.2957/kanzo.42.688

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  • Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression Reviewed

    S Terai, H Aoki, K Ashida, SS Thorgeirsson

    HEPATOLOGY   32 ( 2 )   357 - 366   2000.8

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  • Does cytoplasmic cyclin D1 regulate the cell cycle directly? Reviewed

    Terai S, Okita K

    J Gastroenterol.   32 ( 2 )   357 - 66   2000.8

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  • Antitumor effect of vesnarinone on human hepatocellular carcinoma cell lines Reviewed

    K Kubo, Y Matsuzaki, A Kato, S Terai, K Okita

    INTERNATIONAL JOURNAL OF ONCOLOGY   14 ( 1 )   41 - 46   1999.1

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  • Percutaneous hot water injection and microwave coagulation therapy for hepatocellular carcinoma

    Yamasaki Takahiro, Kato Akira, Kusano Noriyoshi, Hironaka Kouji, Kubo Keiko, Terai Shuji, Kurokawa Fumie, Yabushita Yoshiko, Mori Kenji, Mizumachi Shuji, Okita Kiwamu

    Journal of Microwave Surgery   16   37 - 41   1998

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    We compared the usefulness of percutaneous hot water injection and microwave coagulation therapy (PHMCT) and percutaneous microwave coagulation therapy (PMCT) in patients with hepatocellular carcinomas (HCCs). We performed PHMCT in 18 patients with HCCs (23 nodules) measuring less than 30 mm in diameter and PMCT in 5 patients with HCCs (7 nodules).<br>After 1 week of treatment, we performed a dynamic computed tomography (CT) scan to examine the maximum area of necrosis. There was significant difference in long and short axes diameter of the necrotic area between the PHMCT group injected hot water with more than 15 ml and the PMCT group. Our findings indicate that PHMCT is an effective treatment for small HCCs.

    DOI: 10.3380/jmicrowavesurg.16.37

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    Other Link: http://search.jamas.or.jp/link/ui/1999230833

  • Inhibition of tumor necrosis factor-alpha production retards liver regeneration after partial hepatectomy in rats Reviewed

    T Kimura, Sakaida, I, S Terai, Y Matsumura, K Uchida, K Okita

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   231 ( 3 )   557 - 560   1997.2

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  • Wild-type p53 gene-induced morphological changes and growth suppression in hepatoma cells Reviewed

    Shuji Terai, Takafumi Noma, Teruaki Kimura, Atsushi Nakazawa, Fumie Kurokawa, Kiwamu Okita

    Journal of Gastroenterology   32 ( 3 )   330 - 337   1997

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    DOI: 10.1007/BF02934489

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  • The trial of an endermic boiling water local injection treatment for tumor embolism (Vp3) in portal vein first branch of the hepatoma.

    Kanzo   37 ( 9 )   526 - 527   1996.9

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    DOI: 10.2957/kanzo.37.526

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    Other Link: http://search.jamas.or.jp/link/ui/1997067429

  • Clinicopathologic features of early hepatocellular carcinoma Reviewed

    T Yamasaki, F Kurokawa, A Kato, K Irie, K Yutoku, S Terai, Y Matsuzaki, M Yasunaga, K Okita

    HEPATO-GASTROENTEROLOGY   43 ( 10 )   926 - 931   1996.7

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  • Cell death induced by baicalein in human hepatocellular carcinoma cell lines Reviewed

    Y Matsuzaki, N Kurokawa, S Terai, Y Matsumura, N Kobayashi, K Okita

    JAPANESE JOURNAL OF CANCER RESEARCH   87 ( 2 )   170 - 177   1996.2

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  • Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor alpha inhibitors Reviewed

    Y Kubo, M Yasunaga, M Masuhara, S Terai, T Nakamura, K Okita

    HEPATOLOGY   23 ( 1 )   104 - 114   1996.1

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    DOI: 10.1053/jhep.1996.v23.pm0008550029

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  • HIGH MDM2 MESSENGER-RNA EXPRESSION IN HEPATOBLASTOMA CELL-LINES Reviewed

    S TERAI, Y MATSUZAKI, M MASUHARA, S KONDOU, M YASUNAGA, K OKITA

    INTERNATIONAL HEPATOLOGY COMMUNICATIONS   3 ( 6 )   330 - 336   1995.6

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  • PERCUTANEOUS HOT-WATER INJECTION THERAPY (PHOT) FOR TREATMENT OF HEPATOCELLULAR-CARCINOMA - A COMPARISION WITH PERCUTANEOUS ETHANOL INJECTION THERAPY (PEIT)

    T YAMASAKI, Y MATSUZAKI, K IRIE, S TERAI, A YAMASHITA, F KUROKAWA, M YASUNAGA, K OKITA

    INTERNATIONAL HEPATOLOGY COMMUNICATIONS   3 ( 6 )   305 - 309   1995.6

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  • Clinical study on hot water local injection therapy (PHoT) for hepatoma.Comparison with percutaneous ethanol injection therapy (PEIT).

    山崎隆弘, 松崎祐子, 入江和彦, 寺井崇二, 山下仰, 黒川典枝, 安永満, 沖田極

    肝臓   35 ( 7 )   570 - 571   1994.7

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    DOI: 10.2957/kanzo.35.570

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  • Endoscopic ligation of gastric varices using a detachable snare Reviewed

    T. Yoshida, N. Hayashi, N. Suzumi, S. Miyazaki, S. Terai, T. Itoh, S. Nishimura, T. Noguchi, K. Hino, M. Yasunaga, M. Tada, K. Okita

    Endoscopy   26 ( 5 )   502 - 505   1994

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    DOI: 10.1055/s-2007-1009013

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  • A case of chronic hepatitis exacerbated by alpha-interferon therapy Reviewed

    Yuko Matsuzaki, Keisuke Hino, Yuko Nishizaki, Shuji Terai, Michiari Okuda, Kouzou Kayano, Masafumi Kubota, Kazuyuki Takenaka, Kenji Mori, Aogu Yamashita, Masaaki Masuhara, Norie Kurokawa, Osamu Sakaida, Fujio Murakami, Mitsuru Yasunaga, Kiwamu Okita

    Japanese Journal of Gastroenterology   91 ( 4 )   933 - 937   1994

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    DOI: 10.11405/nisshoshi1964.91.933

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  • Combination Therapy for Intestinal Amebiasis Using an Anti‐amebic Drug and Total Parenteral Nutrition —Report of Two Cases— Reviewed

    Shuji TERAI, Isao SAKAIDA, Mitsuru YASUNAGA, Kiwamu OKITA, Yasushi SHINGAI, Mitsuru SAITO, Harushige FURUTANI, Kojiro SHIGETA, Motoshige INOUE, Motohiro TAKESHIGE

    Digestive Endoscopy   5 ( 1 )   89 - 93   1993

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    DOI: 10.1111/j.1443-1661.1993.tb00599.x

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  • Endoscopic Findings of Primary Sclerosing Cholangitis—‐Report of a Case— Reviewed

    Shuji TERAI, Tetsuji AKIYAMA, Masaaki NAKAMURA, Tsuyoshi AIBE, Kiwamu OKITA, Kazutoshi SANUKI

    Digestive Endoscopy   4 ( 1 )   50 - 55   1992

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    DOI: 10.1111/j.1443-1661.1992.tb00225.x

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  • JAPANESE BETA-THALASSEMIA [CODON-90 (GAG-]TAG)] HAS AT LEAST 2 ORIGINS Reviewed

    Y HATTORI, Y YAMASHIRO, Y OHBA, T MIYAJI, S TERAI, M MORISHITA, K YAMAMOTO, K YAMAMOTO, N MATSUMOTO, F KAWANO

    HEMOGLOBIN   16 ( 4 )   303 - 308   1992

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  • 新規簡易ポリソノグラフィーを用いた肝硬変患者の睡眠障害の特徴

    上村博輝, 内山敦司, 登内孝文, 三井田秀, 丸山弘貴, 土屋淳紀, 大藏倫博, 寺井崇二

    日本消化器病学会雑誌(Web)   121   2024

  • Development of liver fibrosis treatment using extracellular vesicles

    阿部寛幸, 弥久保俊太, 古山海斗, 武田信峻, 水戸將貴, 土屋淳紀, 寺井崇二

    日本再生医療学会総会(Web)   23rd   2024

  • My experience in extracellular vesicle research and therapeutic development as a member of The Japanese Society for Regenerative Medicine

    土屋淳紀, 阿部寛幸, 寺井崇二

    日本再生医療学会総会(Web)   23rd   2024

  • Cell therapy for Liver cirrhosis in our institution: From basic research to clinical trials

    渡邉雄介, 木村成宏, 阿部寛幸, 土屋淳紀, 寺井崇二

    日本再生医療学会総会(Web)   23rd   2024

  • Phase II physician-initiated clinical trial in patients with chronic liver disease to evaluate the effect of S-005151 on Fibrosis Improvement

    土屋淳紀, 阿部寛幸, 寺井崇二

    日本再生医療学会総会(Web)   23rd   2024

  • 慢性肝疾患患者を対象にしたS-005151の第2相医師主導治験結果

    土屋淳紀, 阿部寛幸, 寺井崇二

    日本消化器病学会雑誌(Web)   121   2024

  • DOAC含有LA陽性検体のPTおよびAPTT測定におけるDOAC吸着剤の効果

    松田 将門, 小宮山 豊, 家子 正裕, 星山 良樹, 森山 雅人, 寺井 崇二, 橋口 照人

    日本検査血液学会雑誌   24 ( 学術集会 )   S153 - S153   2023.7

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  • 腸内細菌の外膜小胞は肝硬変で微小環境に影響を与え炎症・線維化増悪をもたらす

    土屋淳紀, 夏井一輝, 寺井崇二

    肝細胞研究会プログラム・抄録集   30th   2023

  • 採血予約制の導入の効果

    松田 将門, 森田 祐貴, 星山 良樹, 寺井 崇二

    日本臨床検査医学会誌   70 ( 補冊 )   167 - 167   2022.10

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  • Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease during Remission: A Comprehensive Review

    Kazuya Takahashi, Iman Geelani Khwaja, Jocelyn Rachel Schreyer, David Bulmer, Madusha Peiris, Shuji Terai, Qasim Aziz

    Crohn's and Colitis 360   3 ( 4 )   2021.10

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    DOI: 10.1093/crocol/otab073

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  • 3社のフェリチン測定試薬の性能評価

    廣瀬 靖華, 松田 将門, 星山 良樹, 寺井 崇二

    医療検査と自動化   46 ( 4 )   490 - 490   2021.8

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  • アンモニア測定における専用分析装置と汎用自動分析装置の測定性能の比較

    田中 雄也, 松田 将門, 星山 良樹, 寺井 崇二

    医療検査と自動化   46 ( 4 )   488 - 488   2021.8

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  • レボヘムAT試薬の性能評価

    松田 将門, 星山 良樹, 寺井 崇二

    医療検査と自動化   46 ( 4 )   469 - 469   2021.8

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  • 1-kestoseが高齢サルコペニアの腸内細菌と筋肉量に与える影響

    冨永顕太郎, 土屋淳紀, 寺井崇二

    肝臓   62 ( Supplement 2 )   2021

  • 食道アカラシア患者における内視鏡的筋層切開術前後での体組成変化の検討

    水澤健, 佐藤裕樹, 寺井崇二

    日本肥満学会・日本肥満症治療学会合同学術集会プログラム・抄録集   41st-38th (Web)   2021

  • Secondary Achalasia in myotonic dystrophy may have a different pathology and management

    Hiroki Sato, Ken-Ichi Mizuno, Satoru Hashimoto, Masafumi Takatsuna, Shuji Terai

    Internal Medicine   59 ( 6 )   875   2020.3

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:Japanese Society of Internal Medicine  

    DOI: 10.2169/internalmedicine.3790-19

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  • 【難治性腹水の対策】肝腎症候群

    薛 徹, 荒生 祥尚, 上村 博輝, 坂牧 僚, 横尾 健, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    消化器・肝臓内科   7 ( 2 )   169 - 174   2020.2

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  • ラット膝関節軟骨全層欠損モデルにおけるヒト脂肪幹細胞の関節内注入後の局在と軟骨欠損修復効果の検討

    富山泰行, 目良恒, 目良恒, 大池直樹, 大橋瑠子, 土屋淳紀, 谷藤理, 望月友晴, 遠藤直人, 寺井崇二

    日本再生医療学会総会(Web)   19th   2020

  • Localization of human Adipose tissue-derived mesenchymal stem cells injected intra-articularly for rat cartilage defect repair

    富山泰行, 目良恒, 目良恒, 大池直樹, 野中秀紀, 上野惟, 大橋瑠子, 土屋淳紀, 谷藤理, 望月友晴, 遠藤直人, 寺井崇二

    日本軟骨代謝学会プログラム・抄録集   33rd   2020

  • オステオポンチン・脂肪酸・高トリグリセライド血症による膵癌高リスク患者の同定

    五十嵐聡, 林和直, 寺井崇二

    膵臓(Web)   35 ( 3 )   2020

  • ハイドロダイナミック遺伝子導入法による肝線維化・肝癌に対する遺伝子治療研究

    上村顕也, 横尾健, 阿部寛幸, 三浦浩美, 大塚正人, 尾田雅文, 仁科博史, 寺井崇二

    肝細胞研究会プログラム・抄録集   27th   2020

  • 側方発育型大腸腫瘍と肥満ならびに代謝指数に関する検討

    高綱将史, 水野研一, 川田雄三, 冨永顕太郎, 水澤健, 佐藤裕樹, 五十嵐聡, 林和直, 横山純二, 橋本哲, 寺井崇二

    Gastroenterological Endoscopy (Web)   62 ( Supplement1 )   2020

  • 当院におけるクローン病の患者に対する内視鏡的小腸結腸拡張術の臨床的検討

    富吉圭, 川田雄三, 冨永顕太郎, 橋本哲, 横山純二, 寺井崇二

    Gastroenterological Endoscopy (Web)   62 ( Supplement1 )   2020

  • 健診での生活歴から考察したNAFLD症例に対する新しい生活指導法の提案

    横尾健, 中野応央樹, 佐藤公俊, 冨永顕太郎, 橋本哲, 高村昌昭, 寺井崇二

    肝臓   61 ( Supplement 1 )   2020

  • Examination of drinking habits and body composition change in patients with recurrent superficial esophageal cancer

    水澤健, 橋本哲, 上村博輝, 高村昌昭, 寺井崇二

    アルコール医学生物学研究会学術集会プログラム・抄録集(Web)   39th   2020

  • Examination of drinking habits and body composition change in patients with recurrent superflcial esophageal cancer

    水澤健, 橋本哲, 上村博輝, 高村昌昭, 寺井崇二

    アルコールと医学生物学   39   2020

  • 高度血小板減少症合併肝硬変例に対する内視鏡的静脈瘤治療におけるルストロンボパグの有用性

    荒生 祥尚, 坂牧 僚, 高村 昌昭, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   35 ( 2 )   141 - 141   2019.12

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  • Antiprogramed cell death-1 therapy with microspheres for metastatic liver tumors. International journal

    Hiroteru Kamimura, Nobutaka Takeda, Takashi Owaki, Takeshi Mizusawa, Takahiro Iwasawa, Satoshi Ikarashi, Satoru Hashimoto, Masaaki Takamura, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   3 ( 6 )   542 - 543   2019.12

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    Anti-programmed cell death-1 therapy with microspheres is an effective treatment for metastatic liver tumors.

    DOI: 10.1002/jgh3.12213

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  • Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions. International journal

    Yuichi Kojima, Atsunori Tsuchiya, Masahiro Ogawa, Shunsuke Nojiri, Suguru Takeuchi, Takayuki Watanabe, Kenji Nakajima, Yukio Hara, Junji Yamashita, Junichi Kikuta, Masaaki Takamura, Masaru Ishii, Shuji Terai

    Regenerative therapy   11   269 - 281   2019.12

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    Background: Mesenchymal stem cells (MSCs) can be easily expanded. They can be acquired from medical waste such as adipose and umbilical cord tissues, are influenced by culturing conditions, and exert anti-inflammatory, antioxidant, anti-fibrotic, and angiogenic effects. We analyzed the multi-directional effects of MSCs cultured under hypoxic conditions and their underlying mechanisms in the treatment of liver cirrhosis in a mouse model. Methods: Human bone marrow-derived MSCs cultured under hypoxic (5% O2; hypoMSCs) and normoxic (21% O2; norMSCs) conditions were compared by cap analysis of gene expression (CAGE) with or without serum from liver cirrhosis patients. The therapeutic effects of MSCs, including serum liver enzyme induction, fibrosis regression, and hepatic oxidative stress, were evaluated by injecting 1 × 106, 2 × 105, or 4 × 104 MSCs/mouse into the tail veins of mice with carbon tetrachloride (CCl4)-induced liver cirrhosis. Intravital imaging was performed with a two-photon excitation microscope to confirm the various MSC migration paths to the liver. Results: CAGE analysis revealed that the RNA expression levels of prostaglandin E synthase (Ptges) and miR210 were significantly higher in hypoMSCs than in norMSCs. In vivo analysis revealed that both hypoMSCs and norMSCs reduced serum alanine aminotransferase, oxidative stress, and fibrosis compared to that in control mice in a dose-dependent manner. However, hypoMSCs had stronger therapeutic effects than norMSCs. We confirmed this observation by an in vitro study in which hypoMSCs changed macrophage polarity to an anti-inflammatory phenotype via prostaglandin E2 (PGE2) stimulation. In addition, miR210 reduced the rate of hepatocyte apoptosis. Intravital imaging after MSC administration showed that both cell types were primarily trapped in the lungs. Relatively a few hypoMSCs and norMSCs migrated to the liver. There were no significant differences in their distributions. Conclusion: The therapeutic effect of hypoMSCs was mediated by PGE2 and miR210 production and was greater than that of norMSCs. Therefore, MSCs can be manipulated to improve their therapeutic efficacy in the treatment of liver cirrhosis and could potentially serve in effective cell therapy. MSCs produce several factors with multidirectional effects and function as "conducting cells" in liver cirrhosis.

    DOI: 10.1016/j.reth.2019.08.005

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  • 十二指腸狭窄により発症した前下膵十二指腸動脈瘤破裂の1例

    渡部 はるか, 石井 結唯, 武田 信峻, 夏井 一輝, 荒生 祥尚, 冨永 顕太郎, 林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   65回   59 - 59   2019.11

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  • 当院における肝疾患相談センターの活動と今後の課題

    薛 徹, 荒生 祥尚, 寺井 崇二

    肝臓   60 ( Suppl.3 )   A882 - A882   2019.11

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  • 当県における非専門科対策を中心とした肝疾患診療体制の確立

    上村 博輝, 薛 徹, 荒生 祥尚, 高村 昌昭, 寺井 崇二

    肝臓   60 ( Suppl.2 )   A665 - A665   2019.10

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  • 肝硬変を背景とした門脈血栓に対する治療戦略の検討

    茂木聡子, 横尾健, 熊谷優, 薛徹, 坂牧僚, 上村博輝, 上村顕也, 土屋淳紀, 高村昌昭, 寺井崇二

    日本門脈圧亢進症学会雑誌   25 ( 3 )   71 - 71   2019.9

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  • 非ウイルス性肝硬変時代の門亢症〜ウイルス性との共通点・相違点を中心に〜 原発性胆汁性胆管炎における食道・胃静脈瘤の検討

    薛 徹, 横山 純二, 高綱 将史, 荒生 祥尚, 上村 輝博, 坂牧 僚, 横尾 健, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    日本門脈圧亢進症学会雑誌   25 ( 3 )   110 - 110   2019.9

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  • 【"適応&修復"のサイエンスと臨床応用の最前線】他家間葉系幹細胞投与臨床展開までの道のり 基礎研究展開も含めて

    寺井 崇二, 土屋 淳紀

    別冊Bio Clinica: 慢性炎症と疾患   8 ( 1 )   75 - 78   2019.7

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  • 消化器内視鏡のトラブルシューティング 外瘻ドレナージ先行の超音波内視鏡下胆道ドレナージの有用性

    森田 慎一, 永山 逸夫, 星 隆洋, 阿部 聡司, 八木 一芳, 須田 剛士, 兼藤 努, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   35 ( 1 )   64 - 64   2019.6

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  • 高度血小板減少症合併肝硬変例に対する内視鏡的静脈瘤治療におけるルストロンボパグの有用性

    荒生 祥尚, 坂牧 僚, 高村 昌昭, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   64回   61 - 61   2019.6

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  • OUTCOME OF ENDOSCOPIC BALLOON DILATATION FOR INTESTINAL DILATATION IN PATIENTS WITH CROHN'S DISEASE

    Yuzo Kawata, Junji Yokoyama, Kentaro Tominaga, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   89 ( 6 )   AB344 - AB344   2019.6

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    DOI: 10.1016/j.gie.2019.03.483

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  • CONSIDERATION OF SERUM IGA IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

    Kentaro Tominaga, Yuzo Kawata, Naruhiro Kimura, Takeshi Mizusawa, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Kenichi Mizuno, Satoru Hashimoto, Atsunori Tsuchiya, Junji Yokoyama, Shuji Terai

    GASTROENTEROLOGY   156 ( 6 )   S847 - S847   2019.5

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  • 当院における肝炎医療コーディネーターの活動実態と今後の課題

    廣川光, 廣川光, 堀恵子, 薛徹, 薛徹, 上村博輝, 上村博輝, 上村博輝, 金子奨太, 小師優子, 鶴田恵, 澤栗裕美, 寺井崇二, 寺井崇二, 寺井崇二

    肝臓   60 ( Supplement 1 )   A258   2019.4

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  • 新潟県における肝疾患診療体制の現状

    上村博輝, 菊田玲, 渡辺和仁, 薛徹, 堀井淳一, 寺井崇二

    肝臓   60 ( Supplement 1 )   A283   2019.4

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  • 当院における高齢発症原発性胆汁性胆管炎患者の予後予測マーカーについて

    高村 昌昭, 木村 成宏, 薛 徹, 上村 博輝, 坂牧 僚, 横尾 健, 土屋 淳紀, 上村 顕也, 松田 康伸, 寺井 崇二

    肝臓   60 ( Suppl.1 )   A407 - A407   2019.4

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  • DAA治療予後と残された課題 SVR後発がんとHCV陽性者の撲滅

    是永 匡紹, 榎本 大, 是永 圭子, 横須賀 收, 井出 達也, 井上 貴子, 日高 勲, 柿崎 暁, 小林 良正, 本田 浩一, 小川 浩司, 井上 淳, 池田 房雄, 的野 智光, 江口 有一郎, 日浅 陽一, 寺井 崇二, 持田 智, 溝上 雅史, 考藤 達哉, 肝炎ウイルス陽性者ファローアップ班

    肝臓   60 ( Suppl.1 )   A386 - A386   2019.4

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  • Acute-on-Chronic Liver Failure:我が国の診断基準の有用性と問題点 我が国の新診断基準を用いて解析した新潟大学でのACLF症例のReal World Data

    土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   60 ( Suppl.1 )   A116 - A116   2019.4

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  • Mesenchymal stem cells cultured in hypoxic conditions had multi-directional effects on mice with liver cirrhosis through prostaglandin E2 and miR210 production

    Atsunori Tsuchiya, Yuichi Kojima, Masahiro Ogawa, Shunsuke Nojiri, Suguru Takauchi, Takayuki Watanabe, Hiroteru Kamimura, Masaaki Takamura, Shuji Terai

    JOURNAL OF HEPATOLOGY   70 ( 1 )   E443 - E444   2019.4

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    DOI: 10.1016/S0618-8278(19)30873-4

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  • DAA治療予後と残された課題 SVR後発がんとHCV陽性者の撲滅

    是永 匡紹, 榎本 大, 是永 圭子, 横須賀 收, 井出 達也, 井上 貴子, 日高 勲, 柿崎 暁, 小林 良正, 本田 浩一, 小川 浩司, 井上 淳, 池田 房雄, 的野 智光, 江口 有一郎, 日浅 陽一, 寺井 崇二, 持田 智, 溝上 雅史, 考藤 達哉, 肝炎ウイルス陽性者ファローアップ班

    肝臓   60 ( Suppl.1 )   A386 - A386   2019.4

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  • 肝性脳症治療の変遷 肝臓と消化管―腸・肝・脳相関をベースに―各種肝疾患における腸内細菌叢の変化

    上村顕也, 坂牧僚, 薛徹, 横尾健, 上村博輝, 阿部聡司, 高村昌昭, 寺井崇二

    肝胆膵   78 ( 3 )   441‐446   2019.3

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  • 新たなNASHモデルマウス開発及び間葉系幹細胞による治療効果の検証

    渡邉 貴之, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A363 - A363   2019.3

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  • 高齢肝癌症例におけるソラフェニブの効果と有用性

    横尾 健, 森田 真一, 木村 成宏, 薛 徹, 坂牧 僚, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A413 - A413   2019.3

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  • 当院における肝癌に対する放射線治療の検討

    柴田 理, 上村 顕也, 木村 成宏, 薛 徹, 横尾 健, 坂牧 僚, 上村 博輝, 土屋 淳紀, 高村 昌昭, 丸山 克也, 太田 篤, 海津 元樹, 青山 英史, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A456 - A456   2019.3

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  • 消化器領域における幹細胞研究とその応用 間葉系幹細胞を用いた消化器疾患の再生医療の治療戦略

    土屋 淳紀, 高村 昌昭, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A86 - A86   2019.3

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  • 肝疾患における画像診断の新展開 M2BPGiを用いた効率のよい拾い上げと専門機関でのUS、MRIを用いての肝硬度別の患者管理体制の確立に向けて

    土屋 淳紀, 高村 昌昭, 寺井 崇二

    日本消化器病学会雑誌   116 ( 臨増総会 )   A211 - A211   2019.3

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  • 【肝性脳症治療の変遷】肝臓と消化管 腸・肝・脳相関をベースに 各種肝疾患における腸内細菌叢の変化

    上村 顕也, 坂牧 僚, 薛 徹, 横尾 健, 上村 博輝, 阿部 聡司, 高村 昌昭, 寺井 崇二

    肝・胆・膵   78 ( 3 )   441 - 446   2019.3

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  • Frontiers of sarcopenia research

    吉田 智彰, 横山 純二, 冨永 顕太郎, 上村 博輝, 坂牧 僚, 高村 昌昭, 寺井 崇二

    消化器・肝臓内科 = Gastroenterology & hepatology   5 ( 1 )   120 - 126   2019.1

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  • Effects of Human Adipose Tissue-Derived and Umbilical Cord Tissue-Derived Mesenchymal Stem Cells in a Dextran Sulfate Sodium-Induced Mouse Model. International journal

    Shunzo Ikarashi, Atsunori Tsuchiya, Yuzo Kawata, Yuichi Kojima, Takayuki Watanabe, Suguru Takeuchi, Katsuhide Igarashi, Maky Ideta-Otsuka, Katsuyuki Oki, Masaaki Takamura, Shuji Terai

    BioResearch open access   8 ( 1 )   185 - 199   2019

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    Mesenchymal stem cells (MSCs) can be acquired from medical waste. MSCs are easily expanded and have multiple functions, including anti-inflammatory effects. We evaluated the effects of human adipose tissue-derived MSCs (AD-MSCs) and umbilical cord tissue-derived MSCs (UC-MSCs) in a dextran sulfate sodium (DSS)-induced mouse model. Human AD-MSCs and UC-MSCs (1 × 106 cells) were injected intravenously into a 7-day DSS-induced colitis model. The therapeutic effects of cell origin, injection timing, and supernatants obtained from MSC cultures were evaluated. We also analyzed messenger RNA (mRNA) expression in MSCs, tissues, and intestinal flora. AD-MSCs and UC-MSCs were found to show strong anti-inflammatory effects when injected on day 3 in a mouse model. On day 11, the mRNA levels of inflammatory factors in colon tissues were significantly decreased after injection of MSCs on day 3. Supernatants from MSCs culture decreased mRNA levels of tumor necrosis factor (Tnf)-α, but had reduced therapeutic effects compared with MSC cell injection. RNA sequencing using colon tissues obtained the day after cell injection revealed changes in the TNF-α/nuclear factor-κB and T cell receptor signaling pathways. Additional analyses showed that several factors, including chromosome 10 open reading frame 54, stanniocalcin-1, and TNF receptor superfamily member 11b were increased in MSCs after adding serum from DSS colitis mice. Furthermore, both AD-MSCs and UC-MSCs maintained the balance of intestinal flora. In conclusion, AD-MSCs and UC-MSCs showed therapeutic effects against inflammation after early cell injection while maintaining the intestinal flora. Although supernatants showed therapeutic effects, cell injection was more effective against inflammation.

    DOI: 10.1089/biores.2019.0022

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  • 当科における副乳頭アプローチカニュレーションの工夫

    林和直, 五十嵐聡, 寺井崇二

    Gastroenterological Endoscopy (Web)   61 ( Supplement2 )   2019

  • 膵癌術前胆道ドレナージにおける大口径プラスチックステントの役割

    五十嵐聡, 林和直, 寺井崇二, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 高村昌昭

    Gastroenterological Endoscopy (Web)   61 ( Supplement1 )   2019

  • 慢性膵炎による膵管狭窄に対するステント治療の現状と課題

    林和直, 五十嵐聡, 寺井崇二, 水澤健, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二

    Gastroenterological Endoscopy (Web)   61 ( Supplement1 )   2019

  • 乳癌手術24年後に消化管,リンパ節,皮膚,骨に多発転移をきたした1例

    大脇崇史, 橋本哲, 岩澤貴宏, 水澤健, 五十嵐聡, 上村博輝, 高村昌昭, 周啓亮, 松本吉史, 梅津哉, 寺井崇二

    Endoscopic Forum for Digestive Disease   35 ( 2 )   2019

  • 放射線照射によるDNA損傷時のHHMの機能解析

    丹羽佑輔, 上村顕也, 小川光平, 高昌良, 酒井規裕, 名古屋拓郎, 坂牧僚, 横尾健, 高見太郎, 山本直樹, 坂井田功, 寺井崇二

    肝細胞研究会プログラム・抄録集   26th   2019

  • 術後再建腸管例におけるEUS-FNAの現状と工夫

    五十嵐聡, 林和直, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 高村昌昭, 寺井崇二

    日本消化器病学会雑誌(Web)   116   2019

  • 当院における切除不能局所進行膵癌の治療の現況

    林和直, 五十嵐聡, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 寺井崇二

    日本消化器病学会雑誌(Web)   116   2019

  • 難治性潰瘍性大腸炎に対する治療と今後の課題

    横山純二, 冨永顕太郎, 寺井崇二

    日本消化器病学会雑誌(Web)   116   2019

  • 空置腸炎に対する自家糞便移植の有用性と腸内細菌叢への影響の解明

    冨永顕太郎, 横山純二, 寺井崇二

    日本消化器病学会雑誌(Web)   116   2019

  • 当院における小腸カルチノイド7例の臨床的検討

    冨永顕太郎, 川田雄三, 本田穣, 上村顕也, 横山純二, 寺井崇二, 田島陽介, 中野雅人, 島田能史, 亀山仁史, 若井俊文, アネコフ アレクセイ, 味岡洋一, 阿部達也, 梅津哉, 岩渕三哉

    日本大腸肛門病学会雑誌(Web)   72 ( 5 )   2019

  • ダブルバルーン内視鏡で診断に至った消化管重複症の成人例

    丹羽佑輔, 上村顕也, 小林隆昌, 高橋一也, 冨永顕太郎, 河久順志, 阿部聡司, 川合弘一, 横山純二, 杉野英明, 梅津哉, 寺井崇二

    Endoscopic Forum for Digestive Disease   35 ( 1 )   2019

  • 胃瘻造設によりS状結腸間膜穿孔をきたした一例

    吉田悠紀, 川田雄三, 永山逸夫, 野澤良祐, 冨永顕太郎, 薛徹, 横尾健, 水野研一, 寺井崇二

    日本消化器病学会甲信越支部例会抄録集   65th   2019

  • 食道アカラシア患者の体組成変化の検討-内視鏡的筋層切開術前後での比較-

    水澤健, 佐藤裕樹, 寺井崇二

    Gastroenterological Endoscopy (Web)   61 ( Supplement1 )   2019

  • 当院における肝癌に対する分子標的薬治療の安全性と有効性の検討

    森田真一, 上村顕也, 坂牧僚, 柴田理, 水澤健, 佐藤裕樹, 寺井崇二

    日本内科学会雑誌   108   2019

  • 高齢者表在型食道癌患者における内視鏡的粘膜下層剥離術後の体組成変化の検討

    水澤健, 橋本哲, 上村博輝, 寺井崇二

    日本消化器病学会雑誌(Web)   116   2019

  • Nivolumabに起因する自己免疫性小腸炎の一例

    石井結唯, 小林隆昌, 丹羽佑輔, 高橋一也, 冨永顕太郎, 河久順志, 阿部聡司, 川合弘一, 谷優佑, 横山純二, 寺井崇二

    Endoscopic Forum for Digestive Disease   34 ( 2 )   195   2018.12

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  • 手足症候群に対するヒスチジンの効果

    上村 顕也, 品川 陽子, 後藤 諒, 横尾 健, 坂牧 僚, 上村 博輝, 阿部 聡司, 寺井 崇二

    The Liver Cancer Journal   10 ( Suppl.2 )   25 - 26   2018.12

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  • Pembrolizumabによる二次性硬化性胆管炎が疑われた一例

    小川光平, 上村顕也, 阿部聡司, 高昌良, 冨永顕太郎, 河久順志, 五十嵐聡, 林和直, 坂牧僚, 水野研一, 横山純二, 寺井崇二

    肝臓   59 ( Supplement 3 )   A990   2018.11

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  • 単一県下におけるウイルス性肝炎への残された課題への取り組み

    上村博輝, 坂牧僚, 寺井崇二

    肝臓   59 ( Supplement 3 )   A787   2018.11

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  • C型肝炎SVR後に退縮した多発性限局性脂肪肝の1例

    酒井規裕, 上村顕也, 冨永顕太郎, 坂牧僚, 水野研一, 寺井崇二

    肝臓   59 ( Supplement 3 )   A983   2018.11

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  • 肝動脈化学塞栓療法が奏効した眼球原発悪性黒色腫の肝転移の3例

    武田信峻, 水澤健, 上村博輝, 野尻俊介, 五十嵐聡, 橋本哲, 高村昌昭, 寺井崇二

    肝臓   59 ( Supplement 3 )   A999   2018.11

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  • HCV陽性腎移植レシピエントに対し直接作用型抗ウイルス薬(DAA)で抗ウイルス療法を行った二例

    岩澤貴宏, 高村昌昭, 大脇崇史, 竹内卓, 五十嵐聡, 上村博輝, 橋本哲, 寺井崇二

    肝臓   59 ( Supplement 3 )   A982   2018.11

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  • 消化器内視鏡のトラブルシューティング 外瘻ドレナージ先行の超音波内視鏡下胆道ドレナージの有用性

    森田 慎一, 永山 逸夫, 星 隆洋, 阿部 聡司, 八木 一芳, 須田 剛士, 兼藤 努, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   63回   46 - 46   2018.11

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  • NAFLD診療体系構築における肝硬度測定の意義

    大崎 暁彦, 渡辺 史郎, 須田 剛士, 和栗 暢生, 窪田 智之, 兼藤 努, 佐藤 俊大, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   59 ( Suppl.3 )   A913 - A913   2018.11

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  • 音響放射圧を用いた肝硬度測定の標準化に向けた取り組み

    窪田 智之, 兼藤 努, 須田 剛士, 大崎 暁彦, 和栗 暢生, 渡辺 史郎, 佐藤 俊大, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   59 ( Suppl.3 )   A916 - A916   2018.11

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  • 炎症性腸疾患患者における血清IgAの検討

    冨永 顕太郎, 横山 純二, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2121 - 2121   2018.10

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  • ステロイド使用例における胆管結石治療の現状

    五十嵐 聡, 林 和直, 河久 順志, 冨永 顕太郎, 高橋 一也, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2086 - 2086   2018.10

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  • 超音波内視鏡における音速補正モードの有用性

    林 和直, 五十嵐 聡, 河久 順志, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2110 - 2110   2018.10

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  • 術後胆汁中膵酵素値とERCP後膵炎の関連

    河久 順志, 五十嵐 聡, 林 和直, 荒生 祥尚, 阿部 寛幸, 高橋 一也, 渡邉 順, 横山 純二, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2156 - 2156   2018.10

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  • Classification of Heterogeneous Hepatocellular Carcinoma Using Four Hepatic Progenitor Cell Markers and Three Serum Tumor Markers

    Atsunori Tsuchiya, Satoshi Seino, Yuichi Kojima, Naruhiro Kimura, Toru Setsu, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Kenya Kamimura, Masaaki Takamura, Shuji Terai

    HEPATOLOGY   68   545A - 546A   2018.10

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  • 高齢者原発性胆汁性胆管炎に対する治療選択と長期予後

    上村博輝, 寺井崇二

    肝臓   59 ( Supplement 2 )   A632   2018.9

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  • B型肝炎由来肝細胞癌に関与するNKG2L,NAAsの検討

    上村博輝, 薛徹, 寺井崇二

    肝臓   59 ( Supplement 2 )   A629   2018.9

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  • 消化器内科医とNSTによる新たな疾患介入と病院内高齢者サルコペニア対策

    小師優子, 上村博輝, 上村博輝, 寺井崇二, 寺井崇二

    日本消化器がん検診学会雑誌   56 ( Supplement )   918 - 918   2018.9

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  • A case of left lobectomy-induced mesenteroaxial gastric volvulus

    Arao, Y., Ikemi, M., Takagi, M., Seino, S., Abe, H., Oyanagi, H., Iwaki, T., Oyamatsu, M., Sato, K., Kamimura, K., Terai, S.

    Endoscopic Forum for Digestive Disease   34 ( 1 )   25‐30,63   2018.6

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  • Acute on chronic―慢性病態の急性増悪―総論 Acute‐on‐chronic liver failureの病態―感染症,循環障害の焦点をあてて―

    寺井崇二, 上村博輝, 坂牧僚, 高村昌昭

    肝胆膵   76 ( 6 )   995‐1000   2018.6

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  • 9年間の経過観察を行った、全大腸に潰瘍性大腸炎類似のびまん性発赤粘膜を呈したCrohn病の1例

    阿部 寛幸, 本間 照, 石川 達, 堀米 亮子, 阿部 聡司, 土屋 淳紀, 横山 純二, 西倉 健, 石原 紀子, 加藤 卓, 味岡 洋一, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   34 ( 1 )   82 - 82   2018.6

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  • 超音波内視鏡検査時の十二指腸穿孔に対しOver-The-Scope Clip(OTSC)による創閉鎖が有効であった1例

    森田 慎一, 須田 剛士, 小田 知友美, 星 隆洋, 兼藤 努, 八木 一芳, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   34 ( 1 )   31 - 37   2018.6

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  • 超音波内視鏡検査時の十二指腸穿孔に対しOver-The-Scope Clip(OTSC)による創閉鎖が有効であった1例

    森田 慎一, 須田 剛士, 小田 知友美, 星 隆洋, 兼藤 努, 八木 一芳, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   34 ( 1 )   31 - 37   2018.6

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  • 「進行消化器癌診療の新展開:肝・胆・膵編」 胆管病変診断における逆止弁付胆管ステントシースを用いた胆管生検法の検討

    森田 慎一, 須田 剛士, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   34 ( 1 )   72 - 72   2018.6

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  • RISK FACTORS FOR WALLED-OFF NECROSIS ASSOCIATED WITH SEVERE ACUTE PANCREATITIS: A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY

    Satoshi Ikarashi, Kazunao Hayashi, Hirokazu Kawai, Junji Kohisa, Toshifumi Sato, Yujiro Nozawa, Shinichi Morita, Hiromitsu Oka, Munehiro Sato, Yukio Aruga, Seiichi Yoshikawa, Shuji Terai

    GASTROENTEROLOGY   154 ( 6 )   S289 - S289   2018.5

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  • H.pylori除菌後発見胃癌の内視鏡診断と除菌の功罪 Invited

    八木一芳, 小田知友美, 星隆洋, 森田慎一, 兼藤努, 須田剛士, 寺井崇二

    胃と腸   53 ( 5 )   672 - 683   2018.5

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    DOI: 10.11477/mf.1403201363

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  • 唾液中HBVウイルス量と潜血測定による水平感染リスクの評価と歯科連携

    上村博輝, 山際訓, 寺井崇二

    肝臓   59 ( Supplement 1 )   A245   2018.4

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  • 新潟県における肝炎検査の未受検者に対する肝炎啓発の取り組み

    坂牧僚, 上村博輝, 寺井崇二

    肝臓   59 ( Supplement 1 )   A537 - A537   2018.4

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  • 新潟県におけるウイルス性肝炎の動向と各啓発活動状況

    上村博輝, 坂牧僚, 寺井崇二

    肝臓   59 ( Supplement 1 )   A537 - A537   2018.4

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  • 当院における循環器疾患が肝臓へ与える影響の指標の解析

    上村博輝, 高村昌昭, 寺井崇二

    肝臓   59 ( Supplement 1 )   A179   2018.4

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  • プロポフォールを用いた鎮静によるバルーン内視鏡下ERCPの現況

    河久 順志, 五十嵐 聡, 林 和直, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 横山 純二, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.1 )   762 - 762   2018.4

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  • 消化管機能検査 最新技術とその応用 消化管運動機能検査としての小腸カプセル内視鏡の有用性の検討

    冨永 顕太郎, 横山 純二, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A136 - A136   2018.4

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  • 当院における1型自己免疫性膵炎診療の現状と課題

    林 和直, 五十嵐 聡, 木村 成宏, 河久 順志, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A299 - A299   2018.4

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  • 内臓脂肪面積と生活習慣病、胆膵疾患、膵脂肪変性に関する検討

    河久 順志, 五十嵐 聡, 林 和直, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 上村 博輝, 高村 昌昭, 横山 純二, 川合 弘一, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A393 - A393   2018.4

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  • 自己免疫性肝疾患の最新知見 自己免疫性肝疾患の治療方針決定における経時的肝生検の有用性

    上村 博輝, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A166 - A166   2018.4

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  • 肝線維化:診断・治療の基礎と臨床 肝硬変改善を目指した細胞療法の基礎的研究と臨床への新たな展開

    土屋 淳紀, 渡邉 雄介, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A102 - A102   2018.4

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  • 成因別の肝発がんリスクの臨床的評価法の確立と治療介入 M2BPGiを活用した肝細胞癌リスク患者拾い上げに引き続くMRエラストグラフィーによる詳細なリスク評価を目指した基盤研究

    高村 昌昭, 土屋 淳紀, 寺井 崇二

    肝臓   59 ( Suppl.1 )   A103 - A103   2018.4

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  • IPMNの悪性診断における膵液細胞診の役割

    五十嵐 聡, 林 和直, 河久 順志, 冨永 顕太郎, 高橋 一也, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.1 )   671 - 671   2018.4

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  • 当院におけるIFN Based TherapyとDAA治療後の発癌因子の検討

    上村 博輝, 坂牧 僚, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A345 - A345   2018.4

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  • 内臓脂肪面積と生活習慣病、胆膵疾患、膵脂肪変性に関する検討

    河久 順志, 五十嵐 聡, 林 和直, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 上村 博輝, 高村 昌昭, 横山 純二, 川合 弘一, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A393 - A393   2018.4

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  • 肝臓領域の基礎研究における新しい潮流と臨床応用 低酸素条件下で培養したヒト骨髄由来間葉系幹細胞による肝硬変治療の検討

    小島 雄一, 寺井 崇二, 土屋 淳紀

    肝臓   59 ( Suppl.1 )   A171 - A171   2018.4

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  • 肝線維化の基礎と臨床 より効果的な肝線維化改善を目指した間葉系幹細胞を用いた基礎研究

    土屋 淳紀, 小島 雄一, 寺井 崇二

    肝臓   59 ( Suppl.1 )   A89 - A89   2018.4

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  • 食道アカラシアの診断と治療戦略 経口内視鏡的筋層切開術(POEM)後に生じる逆流性食道炎の検討

    高橋 一也, 佐藤 裕樹, 冨永 顕太郎, 河久 順志, 五十嵐 聡, 林 和直, 水野 研一, 橋本 哲, 横山 純二, 寺井 崇二

    日本消化管学会雑誌   2 ( Suppl. )   135 - 135   2018.2

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  • 【診断と治療のABC[131]肝硬変】 (第5章)合併症とその対策 腹水

    高村 昌昭, 寺井 崇二

    最新医学   別冊 ( 肝硬変 )   182 - 187   2018.2

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  • プロポフォールを用いた鎮静によるバルーン内視鏡下ERCPの現況

    河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 寺井崇二

    Gastroenterological Endoscopy (Web)   60 ( Supplement1 )   762(J‐STAGE)   2018

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  • IPMNの悪性診断における膵液細胞診の役割

    五十嵐聡, 林和直, 河久順志, 冨永顕太郎, 高橋一也, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

    Gastroenterological Endoscopy (Web)   60 ( Supplement1 )   671(J‐STAGE)   2018

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  • Proposal of diagnostic criteria for acute-on-chronic liver failure (ACLF) in Japan

    Satoshi Mochida, Nobuaki Nakayama, Akio Ido, Kazuaki Inoue, Takuya Genda, Yasuhiro Takikawa, Isao Sakaida, Shuji Terai, Osamu Yokosuka, Masahito Shimizu, Hajime Takikawa

    Acta Hepatologica Japonica   59 ( 3 )   155 - 161   2018

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    DOI: 10.2957/kanzo.59.155

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  • 切除不能膵癌における好中球リンパ球比と他の炎症・栄養指標による予後予測能の比較検討

    中野応央樹, 川合弘一, 小林隆昌, 河久順志, 五十嵐聡, 林和直, 横山順二, 寺井崇二

    日本消化器病学会雑誌(Web)   115   2018

  • 重症急性膵炎におけるwalled-off necrosis合併のリスク因子に関する多施設共同後方視的研究

    五十嵐聡, 林和直, 寺井崇二

    日本消化器病学会雑誌(Web)   115   2018

  • 経口内視鏡的筋層切開術(POEM)後に生じる逆流性食道炎の検討

    高橋一也, 佐藤裕樹, 冨永顕太郎, 河久順志, 五十嵐聡, 林和直, 水野研一, 橋本哲, 横山純二, 寺井崇二

    日本消化管学会雑誌   2 ( Supplement )   2018

  • 炎症性腸疾患患者における血清IgAの検討

    冨永顕太郎, 横山純二, 寺井崇二

    Gastroenterological Endoscopy (Web)   60 ( Supplement2 )   2018

  • ステロイド使用例における胆管結石治療の現状

    五十嵐聡, 林和直, 河久順志, 冨永顕太郎, 高橋一也, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

    Gastroenterological Endoscopy (Web)   60 ( Supplement2 )   2018

  • 超音波内視鏡における音速補正モードの有用性

    林和直, 五十嵐聡, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

    Gastroenterological Endoscopy (Web)   60 ( Supplement2 )   2018

  • 当院における1型自己免疫性膵炎診療の現状と課題

    林和直, 五十嵐聡, 木村成宏, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

    日本消化器病学会雑誌(Web)   115   2018

  • 内臓脂肪面積と生活習慣病,胆膵疾患,膵脂肪変性に関する検討

    河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 上村博輝, 高村昌昭, 横山純二, 川合弘一, 寺井崇二

    日本消化器病学会雑誌(Web)   115   2018

  • 重篤な基礎疾患を持たないサイトメガロウイルス小腸炎の特徴と小腸内視鏡の有用性

    横山純二, 冨永顕太郎, 寺井崇二

    日本消化器病学会雑誌(Web)   115   2018

  • 消化管運動機能検査としての小腸カプセル内視鏡の有用性の検討

    冨永顕太郎, 横山純二, 寺井崇二

    日本消化器病学会雑誌(Web)   115   2018

  • レンバチニブが著効した,肝細胞癌,多発肺転移の1例

    柴田理, 上村顕也, 酒井規裕, 森田真一, 水澤健, 佐藤裕樹, 坂牧僚, 寺井崇二

    日本消化器病学会甲信越支部例会抄録集   63rd   2018

  • 肝硬変の治療薬-どのように使いこなすか?トルバプタン

    水澤健, 高村昌昭, 寺井崇二

    月刊消化器・肝臓内科   4 ( 3 )   2018

  • 食道巨大仮性憩室内に発生した扁平上皮癌の1例

    吉田智彰, 橋本哲, 高橋一也, 廣瀬奏恵, 竹内卓, 林和直, 水野研一, 高村昌昭, 佐藤祐一, 寺井崇二, 市川寛, 羽入隆晃, 渡辺玄, 味岡洋一, 梅津哉

    Endoscopic Forum for Digestive Disease   33 ( 2 )   125   2017.11

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  • 臓器間ネットワークからみた肝胆膵の恒常性とその破綻 臓器間ネットワークの破綻による疾患 自律神経線維が肝再生に与えるインパクト

    上村顕也, 井上良介, 名古屋拓郎, 酒井規裕, 寺井崇二

    肝胆膵   75 ( 5 )   967‐972   2017.11

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  • 超音波内視鏡検査時の十二指腸穿孔に対しOver-the-scope-clipping system(OTSC)による創閉鎖が有効であった1例

    森田 慎一, 小田 知友美, 星 隆洋, 兼藤 努, 小林 正明, 八木 一芳, 須田 剛士, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   33 ( 2 )   138 - 138   2017.11

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  • 直接胆道鏡下での三脚鉗子を用いた結石除去術が有効であった胆管空腸吻合術後の肝内結石の1例

    渡邉 貴之, 五十嵐 聡, 林 和直, 名古屋 拓郎, 薜 徹, 土屋 淳紀, 横山 純二, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   33 ( 2 )   131 - 131   2017.11

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  • Intraductal Papillary Neoplasm of the Bile Duct: A Rare Liver Tumor Complicated by Malignancy

    Kentaro Tominaga, Kenya Kamimura, Akira Sakamaki, Shuji Terai

    HEPATOLOGY   66 ( 5 )   1695 - 1697   2017.11

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  • New approaches to hepatic edema by tolvaptan in the elderly population of liver cirrhosis

    Hitoshi Yoshiji, Yasunari Hiramine, Haruki Uojima, Hiroyuki Nakanishi, Akira Hiramatsu, Takuya Iwamoto, Mutsuumi Kimura, Hideto Kawaratani, Shuji Terai, Hirofumi Uto, Isao Sakaida, Namiki Izumi, Kiwamu Okita, Kazuhiko Koike

    HEPATOLOGY   66   956A - 957A   2017.10

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  • Long-term Gene Expression and Effective Prevention of Liver Fibrosis by Liver-Specific Delivery of Oligonucleotide Therapeutics

    Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Yuji Kobayashi, Norihiro Sakai, Takuro Nagoya, Ryo Goto, Akira Sakamaki, Satoshi Abe, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    HEPATOLOGY   66   368A - 369A   2017.10

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  • Human Homologue of Maid contributes to DNA damage response pathway in HCC.

    Kohei Ogawa, Kenya Kamimura, Ryo Goto, Ryosuke Inoue, Yoko Shinagawa, Yuji Kobayashi, Hiroyuki Abe, Satoshi Abe, Akira Sakamaki, Takeshi Yokoo, Hirokazu Kawai, Satoshi Yamagiwa, Taro Takami, Naoki Yamamoto, Isao Sakaida, Shuji Terai

    HEPATOLOGY   66   373A - 373A   2017.10

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  • 世界的動向から考える消化器内科医として注意すべき薬剤耐性

    上村博輝, 上村博輝, 山際訓, 寺井崇二

    日本消化器がん検診学会雑誌   55 ( Supplement )   940   2017.9

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  • 腹腔内膿瘍に対する各種画像modalityを用いたinterventional drainage

    森田 慎一, 小田 知友美, 星 隆洋, 兼藤 努, 八木 一芳, 須田 剛士, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増大会 )   A866 - A866   2017.9

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  • Trousseau症候群を合併した胆管細胞癌の2例

    品川 陽子, 上村 顕也, 酒井 規裕, 熊木 大輔, 小川 光平, 安住 里英, 冨永 顕太郎, 坂牧 僚, 五十嵐 聡, 林 和直, 山本 幹, 水野 研一, 山際 訓, 寺井 崇二

    肝臓   58 ( 9 )   528 - 535   2017.9

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  • 消化器内視鏡のリスクマネージメント 医療事故調査委員会の現状から 世界的動向から考える消化器内科医として注意すべき薬剤耐性

    上村 博輝, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   59 ( Suppl.2 )   1968 - 1968   2017.9

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  • 肝再生研究の進歩 骨髄由来間葉系幹細胞と誘導マクロファージの混合投与療法による肝再生機序

    土屋 淳紀, 渡邉 雄介, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増大会 )   A523 - A523   2017.9

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  • NAFLDにおけるイベント発生の前方視的検討

    川合 弘一, 松田 康伸, 阿部 聡司, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 石川 達, 山際 訓, 杉谷 想一, 渡辺 雅史, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増大会 )   A769 - A769   2017.9

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  • 肝外転移を伴う肝細胞癌の予後予測因子の検討

    竹内 卓, 高村 昌昭, 阿部 聡司, 坂牧 僚, 上村 顕也, 土屋 淳紀, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   58 ( Suppl.2 )   A608 - A608   2017.9

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  • 肝再生研究の進歩 骨髄由来間葉系幹細胞と誘導マクロファージの混合投与療法による肝再生機序

    土屋 淳紀, 渡邉 雄介, 寺井 崇二

    肝臓   58 ( Suppl.2 )   A523 - A523   2017.9

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  • 骨髄由来細胞による肝線維化改善機序の解析

    渡邉 雄介, 土屋 淳紀, 小島 雄一, 清野 智, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   58 ( Suppl.2 )   A652 - A652   2017.9

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  • 当科における超高齢者の術後再建腸管に対するERCPの検討

    河久順志, 五十嵐聡, 林和直, 高村昌昭, 横山純二, 寺井崇二

    日本高齢消化器病学会誌   20 ( 1 )   63   2017.7

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  • 肝癌薬剤耐性におけるエクソソームの有用性および課題

    松田 康伸, 寺井 崇二

    Medical Science Digest   43 ( 7 )   334 - 337   2017.6

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  • Budd-Chiari症候群を呈した肝単包虫症(Hepatic cystic echinococcosis)の一例

    森田 慎一, 小田 知友美, 星 隆洋, 兼藤 努, 八木 一芳, 須田 剛士, 平野 謙一郎, 小杉 伸一, 長谷川 剛, 迫 康仁, 寺井 崇二

    日本臨床寄生虫学会大会プログラム・講演要旨   28回   39 - 39   2017.6

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  • 消化器疾患における再生医療

    土屋 淳紀, 小島 雄一, 清野 智, 渡邉 雄介, 川田 雄三, 五十嵐 俊三, 中島 尚, 橋本 哲, 横山 純二, 寺井 崇二

    腎臓内科・泌尿器科   5 ( 6 )   587 - 593   2017.6

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  • Serial liver biopsiesで確定診断に至った自己免疫性急性肝不全の一例

    上村 博輝, 山際 訓, 中島 尚, 菅野 智之, 横尾 健, 上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 野本 実, 梅津 哉, 岩崎 友洋, 小方 則夫, 寺井 崇二

    肝臓   58 ( 6 )   373 - 374   2017.6

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  • 肝硬変 : 代償性肝硬変を中心に : 慢性肝炎とどう違うのか? (特集 肝臓を診る : 肝臓病のキモ) -- (肝不全・肝硬変・肝細胞がん)

    高村 昌昭, 寺井 崇二

    内科 = Internal medicine : 臨床雑誌   119 ( 6 )   1169 - 1171   2017.6

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    Other Link: http://search.jamas.or.jp/link/ui/2017264379

  • 【自己免疫性肝・胆管疾患のupdate】 診断、治療 PBC、PSC薬物治療

    山際 訓, 薛 徹, 本多 彰, 寺井 崇二

    肝・胆・膵   74 ( 6 )   925 - 931   2017.6

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  • Long-Term Outcome of Endoscopic Submucosal Dissection in Esophageal Squamous Cell Carcinoma Invading Into the Muscularis Mucosa or Submucosa Up to 200 mu m

    Kazuya Takahashi, Satoru Hashimoto, Kenichi Mizuno, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB108 - AB108   2017.5

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    DOI: 10.1016/j.gie.2017.03.161

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  • Feasibility of Endogel (TM) Simulation Training for Per-Oral Endoscopic Myotomy (POEM): First United Kingdom Experience

    Shraddha Gulati, Andrew Emmanuel, Haruhiro Inoue, Ken-ichi Mizuno, Hiroki Sato, Shuji Terai, Amyn Haji, Bu Hayee

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB152 - AB153   2017.5

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  • 術後腹腔内膿瘍に対して超音波内視鏡下経消化管的ドレナージ(EUS-guided transmural drainage:EUS-TD)が有用であった2症例

    森田 慎一, 星 隆洋, 兼藤 努, 小林 正明, 須田 剛士, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   33 ( 1 )   49 - 49   2017.5

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  • 肝細胞癌におけるa disintegrin and metalloprotease(ADAM)21発現の意義:in vivoでの検討と切除症例での臨床病理学的意義の検討

    高村昌昭, 本田博樹, 山際訓, 玄田拓哉, 松田康伸, 若井俊文, 寺井崇二

    肝臓   58 ( Supplement 1 )   A289 - A289   2017.4

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  • 慢性肝疾患のそう痒症に対するナルフラフィン塩酸塩の長期的効果と安全性の検証

    上村 顕也, 横尾 健, 上村 博輝, 坂牧 僚, 阿部 聡司, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   58 ( Suppl.1 )   A462 - A462   2017.4

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  • SUBMUCOSAL INJECTION OF THE OLIGONUCLEOTIDE STNM01 IS ABLE TO INDUCE CLINICAL REMISSION, MUCOSAL HEALING AND HISTOLOGICAL RESPONSE IN LEFT-SIDED ULCERATIVE COLITIS PATIENTS WITH MODERATE-TO-SEVERE DISEASE

    Raja Atreya, Tanja Kuehbacher, Maximilian Waldner, Simon Hirschmann, Oliver Drvarov, Raed Abu Hashem, Christian Maaser, Torsten Kucharzik, Johanna Dinter, Jessica Mertens, Christoph Schramm, Babett Holler, Joachim MSsner, Kenji Suzuki, Junji Yokoyama, Shuji Terai, Hiroyuki Yoneyama, Hitoshi Asakura, Toshifumi Hibi, Markus Neurath

    GASTROENTEROLOGY   152 ( 5 )   S186 - S186   2017.4

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  • 肝前駆細胞マーカー陽性肝細胞癌の臨床的特徴とAFP-L3分画を用いた拾い上げの可能性の検討

    清野 智, 土屋 淳紀, 小島 雄一, 渡邉 雄介, 阿部 聡司, 坂牧 僚, 上村 顕也, 高村 昌昭, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   58 ( Suppl.1 )   A268 - A268   2017.4

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  • 肝動脈化学塞栓療法/肝動注化学療法にて治療した肝細胞癌患者におけるL3SMI6ヵ月間変化率による予後解析

    小林 隆昌, 川合 弘一, 中野 応央樹, 阿部 聡司, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 山際 訓, 寺井 崇二

    肝臓   58 ( Suppl.1 )   A342 - A342   2017.4

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  • 骨髄由来間葉系幹細胞と誘導型マクロファージの混合投与療法による次世代型肝硬変治療開発のための基盤研究

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    肝臓   58 ( Suppl.1 )   A252 - A252   2017.4

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  • Intervention治療が奏効した術後横隔膜下膿瘍の3例

    森田 慎一, 星 隆洋, 兼藤 努, 小林 正明, 須田 剛士, 池田 洋平, 寺井 崇二

    IVR: Interventional Radiology   32 ( Suppl. )   329 - 329   2017.4

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  • 高齢者におけるデクスメデトミジン鎮静下超音波内視鏡検査の検討

    森田 慎一, 星 隆洋, 兼藤 努, 小林 正明, 須田 剛士, 寺井 崇二

    Gastroenterological Endoscopy   59 ( Suppl.1 )   1012 - 1012   2017.4

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  • 肝線維化治療と肝再生医療の最新知見 次世代型肝再生療法開発への基盤研究

    渡邉 雄介, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増総会 )   A182 - A182   2017.3

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  • 高齢肝細胞癌患者における予後と治療アルゴリズム有用性について

    高村 昌昭, 川合 弘一, 寺井 崇二, 阿部 聡司, 坂牧 僚, 土屋 淳紀, 上村 顕也, 山際 訓

    日本消化器病学会雑誌   114 ( 臨増総会 )   A389 - A389   2017.3

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  • Crohn病診療におけるMR enterographyの役割

    本田 穣, 横山 純二, 冨永 顕太郎, 高橋 一也, 西垣 佑紀, 五十嵐 聡, 林 和直, 水野 研一, 橋本 哲, 佐藤 祐一, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増総会 )   A275 - A275   2017.3

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  • Factural Report of Hepatitis C and Medical Care Subsidies in Niigata Prefecture

    Tsuchiya Atsunori, Terai Shuji

    131 ( 3 )   139 - 143   2017.3

  • 【見直す時期を迎えた肝硬変の治療】 トルバプタンで変わった腹水の管理

    高村 昌昭, 寺井 崇二

    消化器・肝臓内科   1 ( 3 )   285 - 290   2017.3

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  • 粘膜,粘膜下層,さらに筋層の時代へ~Minimally Invasive Treatmentの新たな潮流~〔粘膜下層に対するアプローチ〕Submucosal endoscopyによる筋層生検—経口内視鏡的食道筋層生検術(POEM‐b)による新しい知見—

    佐藤裕樹, 佐藤裕樹, 高橋一也, 中島尚, 水野研一, 橋本哲, 五十嵐聡, 林和直, 本田穣, 横山純二, 佐藤祐一, 本間照, 寺井崇二

    消化器内視鏡   29 ( 2 )   273‐277   2017.2

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  • Status of cell therapy for liver diseases using mesenchymal stem cells

    16 ( 1 )   28 - 38   2017.2

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  • Submucosal injection of the oligonucleotide STNM01 is able to induce clinical remission, mucosal healing and histological response in left-sided ulcerative colitis patients with moderate-to-severe disease

    R. Atreya, T. Kuehbacher, M. J. Waldner, S. Hirschmann, O. Drvarov, R. Abu Hashem, C. Maaser, T. Kucharzik, J. Dinter, C. Schramm, J. Mertens, B. Holler, J. Moessner, K. Suzuki, J. Yokoyama, S. Terai, H. Yoneyama, H. Asakura, T. Hibi, M. F. Neurath

    JOURNAL OF CROHNS & COLITIS   11   S69 - S69   2017.2

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  • 術後再建腸管例に対するERCP関連手技における偶発症の現状と対策

    五十嵐聡, 林和直, 水野研一, 本田穣, 橋本哲, 横山純二, 佐藤祐一, 山際訓, 寺井崇二

    Gastroenterological Endoscopy (Web)   59 ( Supplement1 )   1035(J‐STAGE)   2017

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  • 薬剤過敏症症候群後に潰瘍性大腸炎を発症した一例

    吉田智彰, 横山純二, 高橋一也, 竹内卓, 林和直, 橋本哲, 本田譲, 藤本篤, 渡邊玄, 梅津哉, 佐藤祐一, 寺井崇二

    日本消化管学会総会学術集会プログラム・抄録集   13th   2017

  • 【肝硬変を理解する-分子機構から実臨床に至るまで-】 合併症の病態と治療 腹水・浮腫

    坂牧 僚, 高村 昌昭, 寺井 崇二

    肝・胆・膵   73 ( 6 )   1150 - 1154   2016.12

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  • 一目瞭然!目で診る症例

    小林 隆昌, 土屋 淳紀, 倉岡 直亮, 山本 幹, 本田 穣, 横山 純二, 川合 弘一, 山際 訓, 須田 剛士, 寺井 崇二

    日本内科学会雑誌   105 ( 11 )   2263 - 2267   2016.11

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    DOI: 10.2169/naika.105.2263

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  • Comparative effectiveness of mesenchymal stem cell therapy and macrophage cell therapy in a liver cirrhosis disease model

    Atsunori Tsuchiya, Yusuke Watanabe, Satoshi Seino, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   392 - 392   2016.11

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  • A novel training model made of polyvinyl alcohol hydrogel for endoscopic submucosal dissection

    Ken-Chi Mizuno, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Satoru Hashimoto, Junji Yokoyama, Yuichi Sato, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   277 - 278   2016.11

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  • A flow deviation of the superior mesenteric vein in the liver fits pathological progression/alleviation of nonalcoholic steatohepatitis

    Takeshi Suda, Tsutomu Kanefuji, Takahiro Hoshi, Shinichi Morita, Masaaki Kobayashi, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   406 - 407   2016.11

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  • Hepcidin expression in the intracellular canaliculi of gastric parietal cells and mucosal lymphocyte, including lymph follicles, in patients with Helicobactor pylori-related nodular gastritis and chronic gastritis

    Yuuki Nishigaki, Yuichi Sato, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   76 - 77   2016.11

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  • Histological and transcriptomic analysis of adult japanese medaka sampled onboard the International Space Station

    Shuji Terai, Yasuhiko Murata, Tomomi Watanabe-Asaoka, Shoji Oda, Satoko Uchida, Hiromi Suzuki, Fumiaki Tanigaki, Koichi Fujisawa, Hiroshi Mitani

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   362 - 363   2016.11

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  • Dexmedetomidine-based sedation during ERCP for elderly patients

    Shinichi Morita, Takahiro Hoshi, Tsutomu Kanefuji, Masaaki Kobayashi, Takeshi Suda, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   324 - 325   2016.11

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  • 当院におけるSpy Glass DSの初期経験

    森田 慎一, 星 隆洋, 兼藤 努, 小林 正明, 須田 剛士, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   32 ( 2 )   146 - 146   2016.11

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  • AFP-L3分画陰性化後の再上昇から肝細胞癌の再発を早期に予知し得た2例

    薛 徹, 土屋 淳紀, 寺井 崇二

    肝臓   57 ( Suppl.3 )   A742 - A742   2016.10

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  • IFN関連精神症状と診断された既往があり、DAA治療中にも精神症状を呈したC型慢性肝炎の1例

    坂牧 僚, 上村 顕也, 酒井 規裕, 冨永 顕太郎, 阿部 聡司, 水野 研一, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   57 ( Suppl.3 )   A772 - A772   2016.10

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  • Cultured bone marrow-derived mesenchymal stem cells contributed to improving liver cirrhosis through both the direct stabilization of redox homeostasis and cell- cell interaction with macrophages

    Taro Takami, Toshihiko Matsumoto, Maiko Nishi, Koichi Fujisawa, Naoki Yamamoto, Shuji Terai, Isao Sakaida

    HEPATOLOGY   64   209A - 209A   2016.10

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  • Development of Image-guided, Liver Lobe-specific Hydrodynamic Gene Delivery Method for Gene Therapy in Liver Diseases

    Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Yuji Kobayashi, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    HEPATOLOGY   64   271A - 271A   2016.10

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  • Combination therapy with mesenchymal stem cells and macrophages from bone marrow shows favorable outcome in mouse CCl4-induced liver cirrhosis model

    Yusuke Watanabe, Atsunori Tsuchiya, Yuichi Kojima, Satoshi Seino, Kenya Kamimura, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

    HEPATOLOGY   64   841A - 841A   2016.10

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  • Frequency of CCR7(-)PD-1(+) follicular helper T cell subset as a possible diagnostic marker of autoimmune hepatitis

    Satoshi Yamagiwa, Naruhiro Kimura, Ryoko Horigome, Tomoyuki Sugano, Atsunori Tsuchiya, Kenya Kamimura, Masaaki Takamura, Hirokazu Kawai, Shuji Terai

    HEPATOLOGY   64   822A - 822A   2016.10

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  • C型肝炎撲滅に向けた地域の取り組み 新潟県でのC型肝炎の撲滅に向けたモデル地域づくり 佐渡プロジェクトの立ち上げ

    土屋 淳紀, 山際 訓, 寺井 崇二

    肝臓   57 ( Suppl.3 )   A686 - A686   2016.10

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  • 間葉系幹細胞、マクロファージの相互作用による新しい肝硬変治療を目指して

    土屋 淳紀, 渡邉 雄介, 寺井 崇二

    肝臓   57 ( Suppl.3 )   A746 - A746   2016.10

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  • 自己免疫性肝疾患における基礎と臨床 新たな臨床試験の可能性まで ベザフィブラート投与原発性胆汁性胆管炎症例におけるUDCA投与量の検討

    山際 訓, 松田 康伸, 寺井 崇二

    肝臓   57 ( Suppl.3 )   A664 - A664   2016.10

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  • DPP4発現は膵臓癌予後予測に有用である

    林 和直, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   113 ( 臨増大会 )   A693 - A693   2016.9

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  • 肝幹前駆細胞マーカー陽性肝細胞癌の臨床的意義とAFP-L3での陽性患者予測

    土屋 淳紀, 小島 雄一, 上村 顕也, 高村 昌昭, 熊木 大輔, 平野 正明, 青野 高志, 酒井 剛, 川合 弘一, 山際 訓, 若井 俊文, 寺井 崇二

    肝臓   57 ( Suppl.2 )   A589 - A589   2016.9

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  • 新規サルコペニアマーカー骨格筋量年間変化率は肝動脈化学塞栓療法/肝動注化学療法にて治療された肝細胞癌患者の予後予測に有用である

    小林 隆昌, 川合 弘一, 荒生 祥尚, 横尾 健, 上村 顕也, 土屋 淳紀, 高村 昌昭, 山際 訓, 寺井 崇二

    肝臓   57 ( Suppl.2 )   A607 - A607   2016.9

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  • 内臓脂肪と皮下脂肪のCT断面積によるTACE・TAIにて治療された肝細胞癌患者の予後解析

    小林 隆昌, 川合 弘一, 中野 応央樹, 阿部 聡司, 坂牧 僚, 上村 顕也, 土屋 淳紀, 高村 昌昭, 山際 訓, 寺井 崇二

    肥満研究   22 ( Suppl. )   203 - 203   2016.9

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  • NASHの病態進展における肝ミトコンドリアDNAコピー数と酸化ヌクレオチド・DNA除去機構の検討

    川合 弘一, 荒生 祥尚, 小林 隆昌, 中野 応央樹, 上村 顕也, 寺井 崇二

    肥満研究   22 ( Suppl. )   188 - 188   2016.9

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  • 自己免疫性肝疾患 これからの課題 原発性胆汁性肝硬変に対するUDCA至適投与量の再検討

    山際 訓, 松田 康伸, 寺井 崇二

    肝臓   57 ( Suppl.2 )   A505 - A505   2016.9

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  • 進行肝細胞癌に対するアイエーコールとミリプラの併用肝動注療法の意義 多施設共同研究による第II相試験

    上村 顕也, 横尾 健, 坂牧 僚, 阿部 聡司, 上村 博輝, 兼藤 努, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 須田 剛士, 和栗 暢生, 石川 達, 寺井 崇二

    肝臓   57 ( Suppl.2 )   A560 - A560   2016.9

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  • Assessments of histologic changes after peroral endoscopic myotomy

    Hiroki Sato, Seiji Sagara, Kenji Suzuki, Shuji Terai, Naohisa Yahagi

    GASTROINTESTINAL ENDOSCOPY   84 ( 2 )   377 - 378   2016.8

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  • 腹水の薬物療法 (特集 浮腫 : そのむくみ,放っておいて大丈夫?)

    小島 雄一, 土屋 淳紀, 寺井 崇二

    診断と治療   104 ( 8 )   989 - 994   2016.8

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    Other Link: http://search.jamas.or.jp/link/ui/2016373364

  • Gastrointestinal: Salvage peroral endoscopic myotomy for outflow obstruction with growing esophageal diverticulum

    H. Sato, Y. Sato, S. Hashimoto, K. Mizuno, N. Nakajima, S. Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31 ( 7 )   1237 - 1237   2016.7

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  • A case of spontaneously regressive inflammatory pseudo-tumor in multiple organs (liver, lung, kidney)

    Ikarashi, S., Tsuchiya, A., Nakano, O., Motai, Y., Yamamoto, T., Yokoyama, J., Yokoo, T., Kamimura, K., Takamura, M., Kawai, H., Yamagiwa, S., Terai, S.

    Kanzo/Acta Hepatologica Japonica   57 ( 6 )   287 - 294   2016.6

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    DOI: 10.2957/kanzo.57.287

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  • 腹水・特発性細菌性腹膜炎 (特集 肝硬変のマネージメント : その進歩と課題) -- (肝硬変の合併症とその治療)

    後藤 諒, 高村 昌昭, 寺井 崇二

    消化器の臨床   19 ( 3 )   233 - 237   2016.6

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    Other Link: http://search.jamas.or.jp/link/ui/2016319933

  • Classification of Findings With Narrow-Band Imaging Magnifying Endoscopy for Histological Grading of Superficial Barrett's Esophageal Adenocarcinoma: A Retrospective Study From Japan and Germany

    Manabu Takeuchi, Andreas Probst, Yuichi Sato, Helmut Messmann, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB573 - AB574   2016.5

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  • 肝細胞癌におけるa disintegrin and metalloprotease 21発現の生物学的意義に関する検討

    本田 博樹, 高村 昌昭, 山際 訓, 玄田 拓哉, 木村 成宏, 薛 徹, 冨永 顕太郎, 上村 博輝, 松田 康伸, 若井 俊文, 寺井 崇二

    肝臓   57 ( Suppl.1 )   A247 - A247   2016.4

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  • 脂肪肝、NASHの病態進展におけるミトコンドリアDNAコピー数変化の差異の解析と病態解析

    荒生 祥尚, 川合 弘一, 寺井 崇二

    肝臓   57 ( Suppl.1 )   A201 - A201   2016.4

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  • ラジオ波焼灼術を施行した肝細胞癌患者に対するNomogramを用いた生命予後予測モデルの開発と術前ICG-PDR測定の臨床的意義

    安住 基, 須田 剛士, 横尾 健, 上村 博輝, 土屋 淳紀, 上村 顕也, 高村 昌昭, 川合 弘一, 松田 康伸, 山際 訓, 寺井 崇二

    肝臓   57 ( Suppl.1 )   A158 - A158   2016.4

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  • 当院における自己免疫性肝炎の診断、予後について

    木村 成宏, 山際 訓, 菅野 智之, 倉岡 直亮, 本田 博樹, 上村 顕也, 土屋 淳紀, 高村 昌昭, 寺井 崇二

    肝臓   57 ( Suppl.1 )   A171 - A171   2016.4

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  • ソラフェニブによる手足症候群に対する"濃厚鰹だし"の予防効果

    上村 顕也, 品川 陽子, 小川 光平, 阿部 寛幸, 小林 雄司, 横尾 健, 坂牧 僚, 阿部 聡司, 上村 博輝, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   57 ( Suppl.1 )   A218 - A218   2016.4

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  • 新潟県地域保健・健康増進事業のデータから見るC型肝炎の傾向と対策

    土屋 淳紀, 横尾 健, 上村 顕也, 高村 昌昭, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   57 ( Suppl.1 )   A426 - A426   2016.4

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  • 鰹だしの末梢血流増加作用を利用した手足症候群の予防効果の検証

    上村 顕也, 品川 陽子, 小川 光平, 小林 雄司, 阿部 寛幸, 横尾 健, 上村 博輝, 川合 弘一, 須田 剛士, 山際 訓, 馬場 洋, 寺井 崇二

    癌と化学療法   43 ( 4 )   463 - 465   2016.4

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  • Differences in Clinical Features Between Helicobacter pylori Infection-Associated Type I Gastric Neuroendocrine Tumors (TI-GNETs) and Autoimmune Gastritis-Associated TI-GNETs

    Yuichi Sato, Yuuki Nishigaki, Ryosuke Inoue, Shuji Terai, Manabu Takeuchi

    GASTROENTEROLOGY   150 ( 4 )   S300 - S300   2016.4

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  • Orally Active siRNA Targeting Carbohydrate Sulfotransferase 15 Alleviates Colonic Mucosal Injury in Mice

    Somasundaram Arumugam, Arisa Haino, Tatsuya Ishikawa, Kenji Suzuki, Shuji Terai, Kosei Takeuchi, Shuji Mizumoto, Kazuyuki Sugahara, Masayuki Takahashi, Masato Tamura, Hiroyuki Yoneyama, Masayuki Nashimoto, Kenichi Watanabe

    GASTROENTEROLOGY   150 ( 4 )   S125 - S125   2016.4

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  • Development of Regeneration Therapy for Liver Cirrhosis

    Terai Shuji

    130 ( 4 )   215 - 218   2016.4

  • A new medical expenses subsidy program for inflammatory bowel disease

    256 ( 10 )   1112 - 1117   2016.3

  • 【腎機能を悪化させない日常診療】 肝疾患における腎機能のみかたと対策

    上村 博輝, 山際 訓, 高村 昌昭, 横尾 健, 土屋 淳紀, 上村 顕也, 川合 弘一, 寺井 崇二

    成人病と生活習慣病   46 ( 3 )   370 - 375   2016.3

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  • 臓器特異的ハイドロダイナミック遺伝子導入法による肝疾患の遺伝子治療

    上村 顕也, 横尾 健, 阿部 寛幸, 小林 雄司, 大塚 正人, 三浦 浩美, 小川 光平, 品川 陽子, 井上 良介, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   113 ( 臨増総会 )   A301 - A301   2016.3

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  • Clinicopathological Characterization of Colorectal Micropapillary Carcinoma : Prognosis of Micropapillary Carcinoma in Comparison with Poorly Differentiated Adenocarcinoma

    Kumaki Daisuke, Terai Shuji

    130 ( 3 )   155 - 162   2016.3

  • Pathological Study of Colorectal pSM carcinoma in relation to Treatment Strategies after Endoscopic Resection

    Sato Hiromi, Terai Shuji

    130 ( 3 )   163 - 175   2016.3

  • 【門脈圧亢進症の制御-病態研究と治療の進展】 腹水のマネージメント 新たな利尿薬Tolvaptanは門脈圧を下げるか?

    高橋 俊作, 高村 昌昭, 寺井 崇二

    肝・胆・膵   72 ( 2 )   295 - 299   2016.2

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  • Gene therapy and cell therapy through the liver: Current aspects and future prospects

    Shuji Terai

    Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects   1 - 185   2016.1

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    DOI: 10.1007/978-4-431-55666-4

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  • 【新薬展望2016】 (第III部)治療における最近の新薬の位置付け<薬効別> 新薬の広場 消化器疾患治療薬

    高村 昌昭, 寺井 崇二

    医薬ジャーナル   52 ( 増刊 )   450 - 455   2016.1

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  • 肝硬変症に対する自己骨髄細胞を用いた再生療法

    高見太郎, 西村達朗, 相部祐希, 白築祥吾, 松永一仁, 久永拓郎, 藤澤浩一, 松本俊彦, 丸本芳雄, 山本直樹, 寺井崇二, 坂井田功, 坂井田功

    再生医療   15   2016

  • 難治性食道良性狭窄に対しradial incision and cutting method(RIC法)が奏効した一例

    水澤健, 齋藤悠, 丸山弦, 星隆洋, 森田慎一, 兼藤努, 須田剛士, 小林正明, 塚田芳久, 寺井崇二

    Endoscopic Forum for Digestive Disease   32 ( 2 )   2016

  • Cellular Senescence and Liver Diseases

    Anti-aging medicine   11 ( 6 )   804 - 808   2015.12

  • 【肝臓とアンチエイジング】 老化と肝再生

    土屋 淳紀, 小島 雄一, 清野 智, 渡邉 雄介, 寺井 崇二

    アンチ・エイジング医学   11 ( 6 )   815 - 820   2015.12

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  • CELL THERAPY USING BONE MARROW DERIVED CELL FOR LIVER CIRRHOSIS PATIENT.

    Shuji Terai, Taro Takami, Atsunori Tsuchiya, Isao Sakaida

    TRANSPLANTATION   99 ( 11 )   S70 - S70   2015.11

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  • 最近経験した胃石症の3例 成因および内視鏡的処置法の検討

    小川 光平, 水野 研一, 品川 陽子, 林 和直, 上村 顕也, 阿部 寛幸, 竹内 学, 小林 正明, 小林 英之, 津野 吉裕, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   31 ( 2 )   172 - 172   2015.11

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  • 【コランギオパチー】 免疫介在性コランギオパチー 原発性硬化性胆管炎

    山際 訓, 木村 成宏, 本田 博樹, 上村 博輝, 高村 昌昭, 寺井 崇二

    肝・胆・膵   71 ( 5 )   839 - 844   2015.11

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  • Cell therapy using bone marrow derived cell for liver cirrhosis patient

    Shuji Terai, Taro Takami, Atsunori Tsuchiya, Isao Sakaida

    XENOTRANSPLANTATION   22   S43 - S44   2015.11

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  • 先天性AT‐III欠損症が疑われる上腸間膜静脈・門脈血栓症の1例

    品川陽子, 上村顕也, 小川光平, 水野研一, 竹内学, 阿部寛幸, 高橋祥史, 小林雄司, 野本実, 寺井崇二, 河久順志, 渡辺順, 森山雅人

    新潟医学会雑誌   129 ( 10 )   630 - 630   2015.10

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  • 各種肝疾患における肝細胞ロゼット形成の臨床的意義

    野本 実, 上村 博輝, 土屋 淳紀, 寺井 崇二, 松田 康伸

    新潟医学会雑誌   129 ( 10 )   632 - 633   2015.10

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  • 特異な経過をたどった肝細胞癌の1例

    川田 雄三, 高村 昌昭, 井上 良介, 荒生 祥尚, 高橋 一也, 本田 博樹, 影向 一美, 橋本 哲, 佐藤 祐一, 野本 実, 坂田 純, 若井 俊文, 青柳 豊, 寺井 崇二

    新潟医学会雑誌   129 ( 10 )   618 - 618   2015.10

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  • 小型肺癌から多発肝転移をきたした2例

    倉岡 直亮, 小林 隆昌, 山本 幹, 土屋 淳紀, 須田 剛士, 寺井 崇二, 長谷川 剛, 梅津 哉

    新潟医学会雑誌   129 ( 10 )   619 - 619   2015.10

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  • 食事によりくり返し誘発された門脈ガス血症の1例

    小林 隆昌, 倉岡 直亮, 山本 幹, 本田 穣, 土屋 淳紀, 須田 剛士, 寺井 崇二

    新潟医学会雑誌   129 ( 10 )   627 - 627   2015.10

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  • B-RTOの止血効果に対するリスク因子解析

    渡邉 雄介, 盛田 景介, 林 和直, 兼藤 努, 上村 博輝, 横尾 健, 上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 須田 剛士, 鈴木 健司, 野本 実, 寺井 崇二

    新潟医学会雑誌   129 ( 10 )   628 - 628   2015.10

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  • 効率的なDrug-eluting beadsの調整法

    横尾 健, 兼藤 努, 須田 剛士, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 野本 実, 寺井 崇二

    新潟医学会雑誌   129 ( 10 )   628 - 628   2015.10

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  • 当科における門脈圧亢進症を伴った骨髄増殖性疾患症例の予後に関する検討

    清野 智, 川合 弘一, 横尾 健, 佐藤 裕樹, 本田 穣, 兼藤 努, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 山際 訓, 須田 剛士, 野本 実, 寺井 崇二, 増子 正義, 田中 研介, 柳 雅彦, 佐藤 直子, 矢野 敏雄

    新潟医学会雑誌   129 ( 10 )   631 - 632   2015.10

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  • DJ-1 labeling index is a novel diagnostic biomarker for predicting progression of nonalcoholic steatohepatitis

    Masaaki Takamura, Satoshi Yamagiwa, Yasunobu Matsuda, Minoru Nomoto, Toshifumi Wakai, Shuji Terai

    HEPATOLOGY   62   1263A - 1263A   2015.10

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  • A novel canine liver cirrhosis model to develop less invasive liver regeneration therapy using cultured bone marrow-derived cells

    Takashi Matsuda, Taro Takami, Yuki Aibe, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Naoki Yamamoto, Shuji Terai, Isao Sakaida

    HEPATOLOGY   62   916A - 916A   2015.10

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  • 重複癌に合併した多血性肝腫瘍の1例

    渡邉 貴之, 菅野 智之, 中島 尚, 上村 博輝, 横山 純二, 山際 訓, 野本 実, 寺井 崇二, 梅津 哉, 佐藤 聡史, 岩崎 友洋, 小方 則夫

    新潟医学会雑誌   129 ( 10 )   613 - 613   2015.10

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  • クームス陰性自己免疫性溶血性貧血(AIHA)を合併した急性肝不全の1例

    中島 尚, 菅野 智之, 上村 博輝, 横山 純二, 山際 訓, 野本 実, 寺井 崇二, 梅津 哉, 佐藤 聡史, 岩崎 友洋, 小方 則夫

    新潟医学会雑誌   129 ( 10 )   630 - 630   2015.10

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  • 4 プラチナ系抗腫瘍剤の動注療法が効果的であった肝細胞癌の4例 : 血清APM2濃度の治療効果予測マーカーとしての有用性(Ⅰ.一般演題, 第39回リバーカンファレンス)

    小川 光平, 上村 顕也, 品川 陽子, 阿部 寛幸, 高橋 祥史, 小林 雄司, 熊木 大輔, 水野 研一, 竹内 学, 須田 剛士, 青柳 豊, 寺井 崇二, 和栗 暢生, 石川 達

    新潟医学会雑誌   129 ( 10 )   615 - 615   2015.10

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  • 22 今年度の肝疾患相談センター活動報告と今後の肝炎行政のあり方についての概要(Ⅰ.一般演題, 第39回リバーカンファレンス)

    高村 昌昭, 野田 順子, 上野 徳子, 寺井 崇二

    新潟医学会雑誌   129 ( 10 )   622 - 622   2015.10

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  • 肝臓特異的ハイドロダイナミック法を用いたMatrix metalloproteinase13による肝線維化の遺伝子治療

    小林雄司, 上村顕也, 阿部寛幸, 大塚正人, 横尾健, 三浦浩美, 兼藤努, 須田剛士, 青柳豊, DEXI L, 寺井崇二

    肝臓   56 ( Supplement 2 )   A776 - A776   2015.9

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  • ハイドロダイナミック細胞内遺伝子送達システムの開発

    上村 顕也, 阿部 寛幸, 小林 雄司, 兼藤 努, 横尾 健, 須田 剛士, 上村 博輝, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 寺井 崇二

    肝臓   56 ( Suppl.2 )   A776 - A776   2015.9

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  • 先天性心疾患における器質的な肝障害に関連する因子の同定

    須田 剛士, 杉本 愛, 横尾 健, 上村 博輝, 兼藤 努, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 白石 修一, 渡邉 マヤ, 文 智勇, 高橋 昌, 寺井 崇二

    肝臓   56 ( Suppl.2 )   A784 - A784   2015.9

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  • 肝再生 基礎から臨床 肝幹前駆細胞nicheで産生されるstromal cell derived factor-1(SDF-1)は肝再生促進に関わる

    清野 智, 土屋 淳紀, 寺井 崇二

    日本消化器病学会雑誌   112 ( 臨増大会 )   A640 - A640   2015.9

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  • B型慢性肝炎における核酸アナログ投与後の発癌因子とキャリアにおける水平感染リスクの評価

    上村 博輝, 山際 訓, 高村 昌昭, 横尾 健, 兼藤 努, 上村 顕也, 土屋 淳紀, 川合 弘一, 須田 剛士, 野本 実, 寺井 崇二, 小方 則夫, 大越 章吾, 渡辺 順, 高木 律男

    肝臓   56 ( Suppl.2 )   A763 - A763   2015.9

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  • 自己免疫性肝炎の病理形態像と臨床像の比較検討

    野本 実, 上村 博輝, 寺井 崇二

    肝臓   56 ( Suppl.2 )   A770 - A770   2015.9

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  • 薬剤師が知っておくべき臓器別画像解析の基礎知識 肝臓分野 肝嚢胞の画像診断

    横尾 健, 土屋 淳紀, 山際 訓, 寺井 崇二, 青柳 豊

    医薬ジャーナル   51 ( 9 )   2049 - 2052   2015.9

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  • 慢性腎臓病合併肝細胞癌の予後解析

    木村 成宏, 川合 弘一, 上村 博輝, 兼藤 努, 土屋 淳紀, 上村 顕也, 高村 昌昭, 山際 訓, 須田 剛士, 野本 実, 寺井 崇二

    日本消化器病学会雑誌   112 ( 臨増大会 )   A870 - A870   2015.9

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  • 当科における門脈圧亢進症を伴った骨髄増殖性疾患症例の臨床的特徴と予後に関する検討

    清野 智, 川合 弘一, 横尾 健, 兼藤 努, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 山際 訓, 須田 剛士, 野本 実, 寺井 崇二

    日本消化器病学会雑誌   112 ( 臨増大会 )   A863 - A863   2015.9

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  • 当科と関連施設に於けるC型慢性肝炎に対するIFN治療後発癌の現状

    薛 徹, 山際 訓, 横尾 健, 上村 博輝, 兼藤 努, 上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 須田 剛士, 石川 達, 阿部 聡司, 吉田 俊明, 寺井 崇二

    日本消化器病学会雑誌   112 ( 臨増大会 )   A860 - A860   2015.9

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  • Drug-eluting beadsの調整法の検討

    横尾 健, 兼藤 努, 須田 剛士, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   112 ( 臨増大会 )   A903 - A903   2015.9

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  • 肝細胞癌の予後に影響する栄養学因子

    兼藤 努, 須田 剛士, 横尾 健, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   112 ( 臨増大会 )   A872 - A872   2015.9

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  • 難治性胸・腹水の治療法とその適応 肝細胞癌合併難治性胸腹水症例に対する治療戦略と有効性

    上村 博輝, 山際 訓, 高橋 俊作, 横尾 健, 上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 寺井 崇二

    日本門脈圧亢進症学会雑誌   21 ( 3 )   86 - 86   2015.8

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  • Senescence affects the pathophysiology of nonalcoholic steatohepatitis

    59 ( 8 )   766 - 772   2015.8

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  • 薬剤師が知っておくべき臓器別画像解析の基礎知識 肝臓分野 肝膿瘍の画像診断

    上村 博輝, 山際 訓, 横尾 健, 土屋 淳紀, 上村 顕也, 高村 昌昭, 川合 弘一, 青柳 豊, 寺井 崇二

    医薬ジャーナル   51 ( 8 )   1847 - 1852   2015.8

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  • 【生検を極める】 胃の内視鏡生検に必要な知識と技術

    小林 正明, 水野 研一, 橋本 哲, 竹内 学, 林 和直, 山本 幹, 本田 穣, 横山 純二, 佐藤 祐一, 兼藤 務, 須田 剛士, 寺井 崇二

    消化器内視鏡   27 ( 6 )   966 - 971   2015.6

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    生検を極めるには、スコープ操作や採取手技だけでなく、実際の内視鏡所見を踏まえて、どの場所から生検を採取すると、どのような組織像が得られるのかを予測しながら検査を行うトレーニングが必要である。内視鏡観察を疎かにして、診断を安易に生検に頼っていては、内視鏡検査をいくら行っても実力は身につかない。内視鏡診断力の向上のためには、生検を含めた病理組織診断に関する知識や理解も必要となる。生検後に動脈性出血をきたした経験もあり、緊急止血を含めた偶発症対策も欠かすことはできない。これらは、内視鏡を用いた各種治療手技を目指すための第一歩でもあり確実に習得したい。(著者抄録)

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  • 薬剤師が知っておくべき臓器別画像解析の基礎知識 肝臓分野 限局性結節性過形成の画像診断

    土屋 淳紀, 兼藤 努, 小島 雄一, 清野 智, 渡邉 雄介, 寺井 崇二, 青柳 豊

    医薬ジャーナル   51 ( 5 )   1241 - 1244   2015.5

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  • Image-Guided, Liver-Targeted Hydrodynamic Gene Delivery in Dogs - Preclinical Assessment of Effectiveness and Safety of the Procedure

    Kenya Kamimura, Hiroyuki Abe, Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Yuji Kobayashi, Guisheng Zhang, Masafumi Oda, Yutaka Aoyagi, Shuji Terai, Dexi Liu

    MOLECULAR THERAPY   23   S106 - S107   2015.5

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  • Impact of Injection Volume on Hydrodynamic Delivery To the Liver in Mice

    Tsutomu Kanefuji, Takeshi Yokoo, Takeshi Suda, Kunihiko Sawada, Yoshinori Arai, Hiroyuki Abe, Kenya Kamimura, Dexi Liu, Shuji Terai

    MOLECULAR THERAPY   23   S144 - S144   2015.5

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  • 非アルコール性脂肪肝炎におけるDJ‐1核内発現および血清DJ‐1濃度測定の有用性

    高村昌昭, 山際訓, 松田康伸, 野本実, 青柳豊, 若井俊文, 寺井崇二

    肝臓   56 ( Supplement 1 )   A353 - A353   2015.4

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  • Virtual Touch Quantificationによる肝硬度測定における伝搬速度の測定部位ならびに測定ポイント数の検討

    横尾 健, 兼藤 努, 須田 剛士, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 野本 実, 寺井 崇二

    肝臓   56 ( Suppl.1 )   A429 - A429   2015.4

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  • 肝硬変に対する培養自己骨髄間葉系幹細胞投与療法の開発研究のためのイヌ肝線維化モデル

    松田 崇史, 高見 太郎, 相部 祐希, 石川 剛, 山本 直樹, 寺井 崇二, 坂井田 功

    肝臓   56 ( Suppl.1 )   A345 - A345   2015.4

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  • 新規SGLT2(Sodium-Glucose Co-Transporter2)阻害剤の肝線維化抑制効果の基礎的検討

    山本 直樹, 高見 太郎, 藤澤 浩一, 松本 俊彦, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   56 ( Suppl.1 )   A422 - A422   2015.4

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  • レボカルニチンによるNAFLD治療効果の基礎的検討

    山本 直樹, 高見 太郎, 藤澤 浩一, 松本 俊彦, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   56 ( Suppl.1 )   A469 - A469   2015.4

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  • バソプレシン-V2受容体拮抗薬トルバプタンによる肝線維化抑制効果の基礎的検討

    田邉 規和, 山本 直樹, 松本 俊彦, 藤澤 浩一, 高見 太郎, 寺井 崇二, 坂井田 功

    肝臓   56 ( Suppl.1 )   A540 - A540   2015.4

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  • 自己免疫性肝炎における肝内および末梢血中濾胞性ヘルパーT細胞の検討

    木村 成宏, 山際 訓, 本田 博樹, 薛 徹, 冨永 顕太郎, 上村 博輝, 高村 昌昭, 寺井 崇二

    肝臓   56 ( Suppl.1 )   A295 - A295   2015.4

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  • メチオニン・コリン欠乏食(MCD)誘発性脂肪肝炎に対するDPP-4阻害薬の効果

    山際 訓, 木村 成宏, 本田 博樹, 薛 徹, 冨永 顕太郎, 上村 博輝, 高村 昌昭, 寺井 崇二

    肝臓   56 ( Suppl.1 )   A549 - A549   2015.4

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  • Does an Endoscopic Submucosal Dissection Scar Affect Esophageal Motility?

    Kazuya Takahashi, Manabu Takeuchi, Yuichi Sato, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Shin-ryu Takeda, Masaaki Kobayashi, Shuji Terai

    GASTROENTEROLOGY   148 ( 4 )   S807 - S807   2015.4

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  • 炎症性腸疾患患者の末梢血および大腸粘膜におけるMAIT細胞に関する検討

    冨永 顕太郎, 山際 訓, 薛 徹, 木村 成宏, 鈴木 健司, 寺井 崇二

    日本消化器病学会雑誌   112 ( 臨増総会 )   A345 - A345   2015.3

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  • 【肝胆膵分野の再生医療・人工臓器】 肝 細胞治療による肝再生療法の現状と今後の展開

    土屋 淳紀, 小島 雄一, 清野 智, 渡邊 雄介, 高見 太郎, 坂井田 功, 寺井 崇二

    肝・胆・膵   70 ( 3 )   369 - 374   2015.3

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  • 薬剤師が知っておくべき臓器別画像解析の基礎知識(51)9.肝臓分野(3)転移性肝癌の画像診断

    山際 訓, 寺井 崇二

    医薬ジャーナル   51 ( 3 )   5 - 9   2015.3

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  • 鰹だしの末梢血流増加作用は手足症候群の予防に寄与する

    上村 顕也, 土屋 淳紀, 高村 昌昭, 川合 弘一, 山際 訓, 須田 剛士, 野本 実, 青柳 豊, 寺井 崇二

    日本内科学会雑誌   104 ( Suppl. )   245 - 245   2015.2

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  • A Case of Chronic Hepatitis C with Charcot-Marie-Tooth Disease Successfully Treated with Interferon Beta and Rivabirin Combination Therapy.

    松浦桂司, 日高勲, 花園忠相, 佐伯一成, 岩本拓也, 石川剛, 高見太郎, 川井元晴, 寺井崇二, 神田隆, 坂井田功

    山口医学   64 ( 1 )   2015

  • A Case of Ruptured Hepatocellular Carcinoma Immediately after Transcatheter Arterial Chemoembolization

    福井悠美, 佐伯一成, 花園忠相, 田邉規和, 浦田洋平, 日高勲, 寺井崇二, 坂井田功

    山口医学   64 ( 1 )   2015

  • 非代償性肝硬変に対する自己骨髄細胞を用いた肝再生療法

    高見太郎, 相部祐希, 松田崇史, 久永拓郎, 岩本拓也, 藤澤浩一, 松本俊彦, 丸本芳雄, 石川剛, 山本直樹, 谷健二, 藤井康彦, 田浦保穂, 寺井崇二, 坂井田功, 坂井田功

    肝細胞研究会プログラム・抄録集   22nd   2015

  • 培養自己骨髄間葉系幹細胞投与評価のためのイヌ肝線維化モデル

    松田崇史, 高見太郎, 相部祐希, 石川剛, 山本直樹, 寺井崇二, 坂井田功

    再生医療   14   2015

  • 培養骨髄間葉系幹細胞投与による肝臓再生メカニズムの解明

    高見太郎, 寺井崇二, 藤澤浩一, 山本直樹, 坂井田功

    再生医療   14   2015

  • 肝臓線維化における骨髄由来肝臓修復細胞の特徴

    山本直樹, 寺井崇二, 寺井崇二, 岩本拓也, 高見太郎, 藤澤浩一, 藤澤浩一, 内田耕一, 山崎隆弘, 仁科博史, 坂井田功, 坂井田功

    再生医療   14   2015

  • 複数回投与非培養ABMi療法のための基礎研究

    白築祥吾, 高見太郎, 藤澤浩一, 山本直樹, 寺井崇二, 坂井田功

    再生医療   14   2015

  • 非B非C肝癌の内臓脂肪測定を用いた新たな予測法についての検討

    佐伯 一成, 橋本 真一, 高見 太郎, 山本 直樹, 岡本 健志, 内田 耕一, 寺井 崇二, 坂井田 功

    肥満研究   20 ( Suppl. )   206 - 206   2014.10

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  • Our liver regeneration therapies using autologous bone marrow derived cells for liver cirrhosis

    T. Takami, S. Terai, I. Sakaida

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   17   172 - 172   2014.6

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  • 骨髄由来および脂肪組織由来間葉系幹細胞における生物学的特性の比較解析

    白築 祥吾, 寺井 崇二, 松田 崇史, 石川 剛, 高見 太郎, 山本 直樹, 坂井田 功

    肝臓   55 ( Suppl.1 )   A324 - A324   2014.4

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  • 次世代型経口鉄キレート剤は再発予防剤およびソラフェニブの副作用軽減剤となりうる

    山本 直樹, 山崎 隆弘, 内田 耕一, 佐伯 一成, 高見 太郎, 藤澤 浩一, 寺井 崇二, 坂井田 功

    肝臓   55 ( Suppl.1 )   A269 - A269   2014.4

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  • 培養自己骨髄間葉系幹細胞投与の安全性・有効性および投与経路評価のためのイヌ肝硬変モデル

    松田 崇史, 高見 太郎, 石川 剛, 山本 直樹, 寺井 崇二, 坂井田 功

    肝臓   55 ( Suppl.1 )   A323 - A323   2014.4

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  • The expanding role of fish models in understanding non-alcoholic fatty liver disease (vol 6, pg 905, 2013)

    Yoichi Asaoka, Shuji Terai, Isao Sakaida, Hiroshi Nishina

    DISEASE MODELS & MECHANISMS   7 ( 3 )   409 - 409   2014.3

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  • A Case of Primary Hepatic Neuroendocrine Carcinoma Clinically Suggested.

    KAWASATO Ryo, TERAI Shuji, YAMASAKI Takahiro, SAKAIDA Isao, SHIRATSUKI Shogo, IWAMOTO Takuya, SAEKI Issei, URATA Yohei, HIDAKA Isao, ISHIKAWA Tsuyoshi, TAKAMI Taro, UCHIDA Koichi

    Yamaguchi Medical Journal   63 ( 1 )   53 - 60   2014

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    A hepatic tumor was incidentally detected in an 80-year-old man who was undergoing examination for suspected squamous cell carcinoma of the left external auditory canal with positron emission tomography-computed tomography. Subsequently, the patient was referred to our department for further examination and treatment. The identified hepatic tumor was a 20-mm wide, hypervascular, solitary mass, and no associated chronic liver disorders were observed. Blood tests and imaging studies could not yield an appropriate diagnosis, and therefore, a percutaneous hepatic tumor biopsy was performed. On immunohistochemical staining, positive results were obtained for chromogranin A, synaptophysin, and cluster of differenti-ation 56(CD56),whereas the Ki-67 index was 70%, leading to a definite diagnosis of neuroendocrine carcinoma(small cell carcinoma).Thus, the patient underwent transcatheter arterial chemoembolization(TACE);however, after 4 months, endoscopic ultrasoundfine needle aspiration biopsy confirmed metastasis to the lymph nodes on the anterior surface of the pancreatic head. The patient underwent symptomatic treatment and was kept under observation;however, he died 14 months after TACE. The primary lesion could not be determined even during autopsy. From the clinical course, we believe that it was highly likely that the patient had a primary hepatic neuroendocrine carcinoma.

    DOI: 10.2342/ymj.63.53

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  • Development of a Computer-Simulation Teaching Material Using Video Images for Endoscopic Education Concerning Gastric Cancer no.2 -Educational Practice and Its Assessment to Medical Students-

    小柏香穂理, 浜本義彦, 藤田悠介, 西川潤, 寺井崇二, 坂井田功

    ITヘルスケア誌(Web)   9 ( 2 )   22‐33 (J‐STAGE)   2014

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  • Less invasive liver regeneration therapy for liver cirrhosis using cultured autologous bone marrow-derived mesenchymal stem cells with redox-regulatory capacity

    Taro Takami, Shuji Terai, Luiz Fernando Quintanilha, Bruno D. Paredes, Koichi Fujisawa, Naoki Yamamoto, Isao Sakaida

    HEPATOLOGY   60   419A - 419A   2014

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  • Embolization of splenic artery contributes to controlling elevated portal venous pressure and promoting improved hepatic function induced by occlusion of portosystemic shunts in patients with cirrhosis

    Tsuyoshi Ishikawa, Shogo Shiratsuki, Takashi Matsuda, Takuya Iwamoto, Taro Takami, Shuji Terai, Isao Sakaida

    HEPATOLOGY   60   1193A - 1193A   2014

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  • New canine liver cirrhotic model to develop a less invasive regeneration therapy using cultured autologous bone marrow-derived cells

    Takashi Matsuda, Taro Takami, Tsuyoshi Ishikawa, Naoki Yamamoto, Shuji Terai, Isao Sakaida

    HEPATOLOGY   60   415A - 416A   2014

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  • 培養骨髄間葉系細胞投与による肝臓再生機序の検討

    高見太郎, 寺井崇二, 藤澤浩一, 藤澤浩一, 山本直樹, 山本直樹, 坂井田功, 坂井田功

    再生医療   13   2014

  • 培養自己骨髄間葉系幹細胞投与の安全性および投与経路評価のためのイヌ肝硬変モデル

    松田崇史, 石川剛, 高見太郎, 山本直樹, 山本直樹, 寺井崇二, 坂井田功

    再生医療   13   2014

  • 小型魚類モデルにおいてMaidは細胞増殖,癌化,老化に関わる重要な分子である

    藤澤浩一, 藤澤浩一, 寺井崇二, 高見太郎, 山本直樹, 坂井田功, 山本直樹, 坂井田功

    肝細胞研究会プログラム・抄録集   21st   2014

  • 骨髄由来及び脂肪組織由来間葉系幹細胞(BMSC・ASC)における生物学的特性の差異に関する検討

    白築祥吾, 寺井崇二, 村田泰彦, 松田崇史, 石川剛, 高見太郎, 山本直樹, 坂井田功

    再生医療   13   2014

  • 培養骨髄間葉系幹細胞による肝臓再生療法のメカニズム解析

    高見太郎, 寺井崇二, 松田崇史, QUINTANILHA Luiz Fernando, 藤澤浩一, 山本直樹, 坂井田功, 藤澤浩一, 山本直樹, 坂井田功

    肝細胞研究会プログラム・抄録集   21st   2014

  • 進行肝細胞癌に対するソラフェニブ治療の予後因子の検討

    浦田洋平, 山崎隆弘, 佐伯一成, 内田耕一, 寺井崇二, 沖田幸祐, 山下智省, 沖田極, 坂井田功

    Liver Cancer Journal   5 ( 4 )   282 - 283   2013.12

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  • Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease

    Takahiro Yamasaki, Takashi Oono, Junichi Zaitsu, Issei Saeki, Yoshio Marumoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Koichi Uchida, Shuji Terai, Isao Sakaida

    HEPATOLOGY   58   912A - 912A   2013.10

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  • Basic studies for a less invasive liver regeneration therapy for liver cirrhosis using cultured autologous bone marrow-derived mesenchymal stem cells with stabilization of redox homeostasis

    Taro Takami, Shuji Terai, Luiz Fernando Quintanilha, Koichi Fujisawa, Naoki Yamamoto, Isao Sakaida

    HEPATOLOGY   58   593A - 593A   2013.10

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  • エゼチミブのメダカNASHモデルに対する効果および人NAFLDでの臨床使用経験

    大野 高嗣, 寺井 崇二, 大石 俊之, 桑代 紳哉, 岡本 健志, 橋本 真一, 内田 耕一, 坂井田 功

    肥満研究   19 ( Suppl. )   160 - 160   2013.9

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  • 当科における病的肥満症患者の2症例 CGMでの検討

    内田 耕一, 寺井 崇二, 岡本 健志, 橋本 真一, 大野 高嗣, 坂井田 功

    肥満研究   19 ( Suppl. )   214 - 214   2013.9

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  • 鉄キレート剤による肝線維化・肝発癌の抑制効果

    山本 直樹, 山崎 隆弘, 高見 太郎, 前田 雅喜, 佐伯 一成, 藤澤 浩一, 寺井 崇二, 坂井田 功

    G.I.Research   21 ( 4 )   390 - 391   2013.8

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  • Canine Mesenchymal Stem Cells Present Antioxidant and Hepatoprotective Properties Against TAA-Induced Injury In Vitro and In Vivo

    Luiz Fernando Quintanilha, Taro Takami, Yoshikazu Hirose, Koichi Fujisawa, Yasuhiko Murata, Naoki Yamamoto, Shuji Terai, Isao Sakaida

    GASTROENTEROLOGY   144 ( 5 )   S1025 - S1026   2013.5

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  • 進行肝癌に対する鉄キレート剤の効果

    山崎 隆弘, 佐伯 一成, 在津 潤一, 浦田 洋平, 高見 太郎, 山本 直樹, 寺井 崇二, 坂井田 功

    コンセンサス癌治療   12 ( 2 )   112 - 113   2013.5

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  • 肝再生修復療法としての培養ヒト骨髄間葉系細胞投与療法のメカニズム解析

    高見 太郎, 寺井 崇二, 村田 泰彦, 廣瀬 恵一, 藤澤 浩一, 山本 直樹, 坂井田 功

    肝臓   54 ( Suppl.1 )   A333 - A333   2013.4

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  • ゼブラフィッシュモデルにおける肝腫瘍マーカー分子の解析

    藤澤 浩一, 寺井 崇二, 高見 太郎, 山本 直樹, 坂井田 功

    日本臨床分子医学会学術総会プログラム・抄録集   50回   69 - 69   2013.4

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  • カプセル内視鏡画像解析のための表色系と前処理の評価

    末永雅人, 藤田悠介, 橋本真一, 寺井崇二, 坂井田功, 浜本義彦

    第75回全国大会講演論文集   2013 ( 1 )   427 - 428   2013.3

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    カプセル内視鏡は,従来の胃カメラや大腸カメラでは届かない小腸を撮影する手段として開発された.カプセル内視鏡は一度の検査で数万枚の画像を撮影するため,すべての画像を医師が診断するのは不可能である.そこで,診断支援を目的とし,特に画像内の領域検出の研究がなされてきた.しかし,カプセル内視鏡画像を対象として,領域検出にはいかなる表色系,前処理が有効かについては十分な研究がなされていない.本研究では,カプセル内視鏡画像解析のための最適な表色系,前処理を領域検出の検出精度の観点から調査する.そして,領域検出の精度向上には,RGBの表色系の画像にガウシアンフィルタによる平滑化を施すことが有効であると統計的検定により示されたことを報告する.

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  • Improvement of efficiency of cell therapy using bone marrow derived cell

    244 ( 6 )   555 - 557   2013.2

  • 肝再生修復療法としての培養ヒト骨髄間葉系細胞投与療法のメカニズム解析

    高見太郎, 寺井崇二, 村田泰彦, QUINTANILHA LF, 廣瀬恵一, 藤澤浩一, 藤澤浩一, 山本直樹, 山本直樹, 坂井田功, 坂井田功

    再生医療   12   2013

  • 肝線維化修復時における二種類の骨髄由来細胞の動態と特徴

    山本直樹, 山本直樹, 寺井崇二, 高見太郎, 内田耕一, 藤澤浩一, 藤澤浩一, 仁科博史, 坂井田功, 坂井田功

    再生医療   12   2013

  • Mechanism of bone marrow cell therapy for liver cirrhosis

    44 ( 13 )   581 - 584   2012.11

  • Development of evaluation system using FLI-GFP medaka to screen effective drug to reduce adverse effect of sorafenib

    Shuji Terai, Koichi Fujisawa, Yoshikazu Hirose, Toshihiko Matsumoto, Makoto Furutani-Seiki, Isao Sakaida

    HEPATOLOGY   56   801A - 801A   2012.10

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  • Mesenchymal stem cell with deletion of macrophage is effective for improvement of liver fibrosis

    Shuji Terai, Haruko Tanimoto, Taro Takami, Yoshikazu Hirose, Koichi Fujisawa, Naoki Yamamoto, Isao Sakaida

    HEPATOLOGY   56   330A - 330A   2012.10

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  • 当科における肥満症に対する内視鏡下胃内バルーン留置術の経験

    岡本 健志, 寺井 崇二, 橋本 真一, 内田 耕一, 坂井田 功

    肥満研究   18 ( Suppl. )   185 - 185   2012.9

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  • 防風通聖散(TJ-62)はNASHに対するマクロファージ系の炎症制御効果を持つ治療薬になる

    内田 耕一, 寺井 崇二, 岡本 健志, 橋本 真一, 坂井田 功

    肥満研究   18 ( Suppl. )   181 - 181   2012.9

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  • 肝硬変発癌モデルにおける自己骨髄細胞投与の影響

    前田 雅喜, 高見 太郎, 山本 直樹, 寺井 崇二, 坂井田 功

    G.I.Research   20 ( 4 )   368 - 369   2012.8

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  • Evaluation for serum Oncostatin M : relationship with non-alcoholic steatohepatitis (NASH)

    54 ( 6 )   690 - 693   2012.6

  • 肝再生、幹細胞研究が臨床医学にもたらす可能性 有機-無機・ナノハイブリッドシステムによる低侵襲肝再生修復療法の開発のための基礎的検討

    高見 太郎, 寺井 崇二, 廣瀬 恵一, 藤澤 浩一, 山本 直樹, 坂井田 功

    肝臓   53 ( Suppl.1 )   A130 - A130   2012.4

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  • 肝細胞癌に対する分子標的薬開発の基礎から臨床 肝細胞癌治療に対する鉄キレート剤の新規治療薬としての可能性

    山本 直樹, 山崎 隆弘, 廣瀬 恵一, 佐伯 一成, 前田 雅喜, 高見 太郎, 藤澤 浩一, 寺井 崇二, 坂井田 功

    肝臓   53 ( Suppl.1 )   A116 - A116   2012.4

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  • 進行肝細胞癌に対する新規肝動注化学療法 鉄キレート剤を用いて

    坂井田 功, 山崎 隆弘, 佐伯 一成, 山本 直樹, 内田 耕一, 寺井 崇二

    日本内科学会雑誌   101 ( Suppl. )   154 - 154   2012.2

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  • 肝硬変に対する有機・無機・ナノハイブリッドシステムによる低侵襲再生修復療法の開発のための基礎研究

    高見太郎, 寺井崇二, 谷本治子, 廣瀬恵一, 藤澤浩一, 山本直樹, 武久敢, 高田哲生, 原口和敏, 坂井田功

    再生医療   11   2012

  • 肝硬変に対する自己骨髄細胞投与(ABMi)療法における肝発癌への影響の基礎的検討

    高見太郎, 寺井崇二, 前田雅喜, 廣瀬恵一, 藤澤浩一, 山本直樹, 坂井田功

    再生医療   11   2012

  • Autologous Bone Marrow Cell infusion therapy (ABMi therapy) for liver regeneration

    10 ( 4 )   431 - 435   2011.11

  • 肝再生の基礎と臨床 自己骨髄細胞投与療法の現状と展望

    坂井田 功, 寺井 崇二, 山本 直樹, 高見 太郎, 石川 剛

    日本医学会総会会誌   28回 ( I )   139 - 139   2011.10

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  • HHM(MAID) IS A SPECIFIC REGULATOR TO INHIBIT THE GENERATION OF LIVER TUMOR AND PROGRESSION OF LIVER FIBROSIS. -FROM THE STUDY OF CCL4 INDUCED MAID KO MICE AND DEN EXPOSURED HHM TG MEDAKA FISH-

    Shuji Terai, Naoki Yamamoto, Koichi Fujisawa, Taro Takami, Tomoaki Murata, Isao Sakaida

    HEPATOLOGY   54   1279A - 1280A   2011.10

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  • TWO KIND OF BONE MARROW CELLS PHAGOCYTE DAMAGED HEPATOCYTE AND REPAIR FIBROSIS IN CIRRHOSIS MICE

    Naoki Yamamoto, Shuji Terai, Takuya Iwamoto, Taro Takami, Koichi Uchida, Hiroshi Nishina, Isao Sakaida

    HEPATOLOGY   54   963A - 963A   2011.10

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  • FREQUENT BONE MARROW CELL INFUSION PROMOTES LIVER REGENERATION AND SUPPRESSES TUMOR-INITIATION IN HEPATOCARCINOGENIC MOUSE WITH LIVER CIRRHOSIS

    Masaki Maeda, Taro Takami, Koichi Fujisawa, Naoki Yamamoto, Shuji Terai, Isao Sakaida

    HEPATOLOGY   54   1284A - 1284A   2011.10

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  • DIPEPTIDYL PEPTIDASE-4 (DPP IV) INHIBITOR PREVENTS LIVER FIBROSIS AND PRENEOPLASTIC LESIONS IN RAT LIVER CIRRHOSIS INDUCED BY A CHOLINE-DEFICIENT L-AMINO ACID-DEFINED DIET

    Naoki Yamamoto, Koichi Uchida, Taro Takami, Toshiyuki Oishi, Naoharu Matsunaga, Shuji Terai, Isao Sakaida

    HEPATOLOGY   54   745A - 746A   2011.10

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  • IMPROVEMENT OF LIVER FIBROSIS AND LIVER FUNCTION BY INFUSION OF CULTURED CELLS DERIVED FROM HUMAN BONE MARROW -BASIC RESEARCH DIRECTED TOWARD DEVELOPMENT OF HUMAN BONE MARROW DERIVED CULTURED CELL INFUSION THERAPY-

    Haruko Tanimoto, Shuji Terai, Taro Takami, Naoki Yamamoto, Isao Sakaida

    HEPATOLOGY   54   1218A - 1218A   2011.10

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  • THERMOSENSITIVE ORGANIC/INORGANIC NANOCOMPOSITE GELS-CULTURED BONE MARROW DERIVED CELLS IMPROVED LIVER FIBROSIS IN CARBON TETRACHLORIDE-INDUCED CIRRHOSIS MICE

    Taro Takami, Shuji Terai, Yoshikazu Hirose, Koichi Fujisawa, Naoki Yamamoto, Toru Takehisa, Tetsuo Takada, Kazutoshi Haraguchi, Isao Sakaida

    HEPATOLOGY   54   434A - 434A   2011.10

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  • 小腸カプセル内視鏡を用いたBMIと消化管運動との関連における検討

    橋本 真一, 松永 尚治, 岡本 健志, 内田 耕一, 寺井 崇二, 坂井田 功

    肥満研究   17 ( Suppl. )   153 - 153   2011.9

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  • メダカモデルにおけるNASHが誘導される機序の検討(食事、宿主因子さらに加齢の関与の検討)

    桑代 紳哉, 寺井 崇二, 松永 尚治, 大石 俊之, 橋本 真一, 岡本 健志, 内田 耕一, 坂井田 功

    肥満研究   17 ( Suppl. )   187 - 187   2011.9

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  • 当科における肥満症患者に対するクリニカルパスおよび治療の取り組み

    内田 耕一, 寺井 崇二, 浦田 洋平, 在津 潤一, 岡本 健志, 橋本 真一, 桑代 紳哉, 大石 俊之, 松永 尚治, 坂井田 功

    肥満研究   17 ( Suppl. )   142 - 142   2011.9

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  • 肝硬変高発癌マウスへの自己骨髄細胞投与は肝修復再生を促進し肝発癌を抑制する(Autologous bone marrow cell infusions promote liver regeneration and suppress tumor-initiation in the DEN/GFP-CCI4 mouse)

    前田 雅喜, 高見 太郎, 山本 直樹, 寺井 崇二, 坂井田 功

    日本癌学会総会記事   70回   204 - 204   2011.9

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  • 四塩化炭素(CCl4)誘発性慢性肝障害モデルマウスに対するイヌ骨髄細胞移植の効果

    原口 友也, 谷 健二, 小田 康喬, 高岸 領, 山本 直樹, 寺井 崇二, 坂井田 功, 仲澤 宏, 板本 和仁, 田浦 保穂

    日本獣医学会学術集会講演要旨集   152回   295 - 295   2011.8

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  • マウス肝硬変発癌モデルにおける自己骨髄細胞投与の影響評価

    前田 雅喜, 高見 太郎, 山本 直樹, 寺井 崇二, 坂井田 功

    G.I.Research   19 ( 4 )   406 - 407   2011.8

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  • Evaluations of Physiological Responses to Space Environmental Stresses Using Medaka Live Imaging

    WATANABE ASAKA Tomomi, NIIHORI Maki, TERADA Masahiro, IWASAKI Ken-ichi, ODA Shoji, BABA Shoji A, TERAI Shuji, OMORI Katsunori, MITANI Hiroshi, MUKAI Chiaki

    JASMA : Journal of the Japan Society of Microgravity Application   28 ( 3 )   55 - 61   2011.7

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  • Hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma: Analysis of 114 cases

    Urayama, N., Yamasaki, T., Harimal, Y., Saeki, I., Zaitsu, J., Hamabe, S., Harano, M., Takami, T., Kaino, S., Uchida, K., Terai, S., Sakaida, I.

    Kanzo/Acta Hepatologica Japonica   52 ( 7 )   449 - 460   2011.7

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    DOI: 10.2957/kanzo.52.449

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  • 消化器癌をめぐる栄養療法 肝細胞癌における栄養療法の意義

    山崎隆弘, 播磨陽平, 在津潤一, 浜辺崇衣, 佐伯一成, 沖田幸祐, 原野恵, 浦田洋平, 戒能聖治, 内田耕一, 寺井崇二, 坂井田功

    月刊消化器内科   52 ( 6 )   624 - 633   2011.6

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  • HCCに対するHSP70-mRNA導入樹状細胞療法第I相試験 中間報告

    前田 祥成, 硲 彰一, 爲佐 卓夫, 新藤 芳太郎, 吉村 清, 坂本 和彦, 寺井 崇二, 山崎 隆弘, 坂井田 功, 日野田 裕治, 岡 正朗

    山口医学   60 ( 3 )   77 - 77   2011.6

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  • 肥満症の病態形成における新しい因子 肝・消化管と肥満

    寺井 崇二, 松永 尚治, 大石 俊之, 橋本 真一, 岡本 健志, 内田 耕一, 坂井田 功

    日本肥満症治療学会学術集会プログラム・抄録集   29回   65 - 65   2011.6

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  • 骨髄細胞投与による肝線維化改善作用発現にTNFシグナルが重要である

    久永 拓郎, 寺井 崇二, 高見 太郎, 山本 直樹, 仁科 博史, 坂井田 功

    肝臓   52 ( Suppl.1 )   A363 - A363   2011.4

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  • 骨髄細胞投与による肝硬変合併肝細胞がんに対する新たな抗線維化・抗腫瘍療法開発への基礎研究

    高見 太郎, 寺井 崇二, 前田 雅喜, 久永 拓郎, 山本 直樹, 坂井田 功

    肝臓   52 ( Suppl.1 )   A267 - A267   2011.4

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  • 肝線維化修復時における二種類の骨髄由来細胞の動態と特徴

    山本 直樹, 寺井 崇二, 岩本 拓也, 高見 太郎, 内田 耕一, 仁科 博史, 坂井田 功

    肝臓   52 ( Suppl.1 )   A285 - A285   2011.4

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  • ヒト骨髄由来培養細胞投与による肝線維化・肝機能改善

    谷本 治子, 寺井 崇二, 渡辺 尚子, 藤沢 浩一, 高見 太郎, 山本 直樹, 坂井田 功

    肝臓   52 ( Suppl.1 )   A361 - A361   2011.4

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  • 血清オンコスタチンM(OSM)濃度測定によるリザーバー動注療法施行進行肝癌患者における長期予後予測の可能性

    在津 潤一, 寺井 崇二, 大石 俊之, 久永 拓郎, 浦田 洋平, 日高 勲, 石川 剛, 土屋 昌子, 高見 太郎, 山本 直樹, 内田 耕一, 山崎 隆弘, 坂井田 功

    肝臓   52 ( Suppl.1 )   A228 - A228   2011.4

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  • 肝硬変症に対する自己骨髄細胞投与は肝発がんを抑制する

    前田 雅喜, 高見 太郎, 久永 拓郎, 山本 直樹, 寺井 崇二, 坂井田 功

    肝臓   52 ( Suppl.1 )   A200 - A200   2011.4

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  • 肝硬変症に対する自己骨髄細胞投与療法の現状 (特集 ここまで進んだ先端医療) -- (再生医療)

    寺井 崇二, 坂井田 功

    臨牀と研究   88 ( 4 )   435 - 438   2011.4

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  • Aging affect the pathology of non-alcoholic steatohepatitis

    66 ( 4 )   874 - 882   2011.4

  • 急性肝不全新規治療法の開発とその課題 骨髄由来Liver Repair細胞を用いた肝臓再生修復療法の現状と今後の課題

    寺井 崇二, 高見 太郎, 石川 剛, 山本 直樹, 坂井田 功

    肝臓   52 ( 3 )   216 - 216   2011.3

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  • Evaluations of Physiological Responses to Space Environmental Stresses Using Medaka Live Imaging

    浅香智美, 新堀真希, 寺田昌弘, 岩崎賢一, 岩崎賢一, 尾田正二, 尾田正二, 馬場昭次, 寺井崇二, 大森克徳, 三谷啓志, 向井千秋

    日本マイクログラビティ応用学会誌(Web)   28 ( 3 )   2011

  • 骨髄細胞投与による肝臓修復再生とTNFシグナルの検討

    久永拓郎, 寺井崇二, 高見太郎, 山本直樹, 仁科博史, 坂井田功

    再生医療   10   2011

  • 四塩化炭素誘導肝硬変マウスにおける骨髄細胞の性状とTNF-αシグナルの関与

    渡邉尚子, 寺井崇二, 高見太郎, 谷本治子, 前田雅喜, 久永拓郎, 藤沢浩一, 山本直樹, 坂井田功

    再生医療   10   2011

  • マウス骨髄由来無血清培養細胞投与による肝線維化・肝機能改善効果

    高見太郎, 寺井崇二, 岩本拓也, 渡邉尚子, 谷本治子, 前田雅喜, 久永拓郎, 藤澤浩一, 山本直樹, 坂井田功

    再生医療   10   2011

  • 肝がんの新規治療法に関する研究 肝癌におけるMaidシグナルの重要性に関する検討

    坂井田功, 寺井崇二, 山本直樹, 藤澤浩一

    肝がんの新規治療法に関する研究 平成22年度 総括・分担研究報告書   2011

  • ヒト骨髄由来培養細胞投与による肝線維化・肝機能改善

    谷本治子, 寺井崇二, 渡辺尚子, 藤沢浩一, 高見太郎, 山本直樹, 坂井田功

    再生医療   10   2011

  • 自己骨髄細胞投与療法における骨髄細胞投与の肝発癌増殖機構への影響評価

    前田雅喜, 高見太郎, 久永拓郎, 山本直樹, 寺井崇二, 坂井田功

    再生医療   10   2011

  • 自己骨髄細胞投与療法における骨髄細胞投与の肝発癌増殖機構への影響評価

    前田 雅喜, 高見 太郎, 久永 拓郎, 山本 直樹, 寺井 崇二, 坂井田 功

    山口医学   59 ( 5-6 )   243 - 243   2010.12

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  • New therapy for liver failure by autologous bone marrow cell infusion

    59 ( 12 )   2466 - 2468   2010.12

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    久永 拓郎, 寺井 崇二, 坂井田 功

    Clinical Engineering   22 ( 1 )   20 - 26   2010.12

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  • 【非アルコール性脂肪肝炎(NASH) 病態の解明と診断・治療法の確立】 代替療法 NASH/NAFLDに対する肝臓再生療法

    久永 拓郎, 寺井 崇二, 坂井田 功

    カレントテラピー   28 ( 12 )   1145 - 1151   2010.12

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  • 宇宙環境が生体に与える影響のメダカを用いた解析 (第127回成医会総会一般演題)

    浅香 智美, 須藤 正道, 新堀 真希, 寺田 昌弘, 尾田 正二, 寺井 崇二, 岩崎 賢一, 向井 千秋, 栗原 敏

    東京慈恵会医科大学雑誌   125 ( 6 )   225 - 225   2010.11

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  • Sonazoid造影超音波検査が有用であった転移性肝カルチノイドの一例

    高見 太郎, 江角 智子, 久永 拓郎, 播磨 陽平, 土屋 昌子, 山口 裕樹, 寺井 崇二, 山崎 隆弘, 坂井田 功

    超音波医学   37 ( 6 )   677 - 677   2010.11

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  • EFFECT OF A NUTRITIONAL THERAPY USING A LATE EVENING SNACK FOR HEPATOCELLULAR CARCINOMA

    Takahiro Yamasaki, Yohei Harima, Issei Saeki, Koichi Uchida, Shuji Terai, Isao Sakaida

    HEPATOLOGY   52 ( 4 )   1179A - 1179A   2010.10

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  • AUTOLOGOUS BONE MARROW CELL INFUSIONS SUPPRESS TUMOR-INITIATION AND DO NOT PROMOTE TUMOR-PROLIFERATION DURING N-NITROSODIETHYLAMINE-INDUCED HEPATOCARCINOGENESIS IN CARBON TETRACHLORIDE-TREATED LIVER CIRRHOSIS MICE

    Taro Takami, Shuji Terai, Masaki Maeda, Naoki Yamamoto, Isao Sakaida

    HEPATOLOGY   52 ( 4 )   966A - 966A   2010.10

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  • DISRUPTION OF MAID ACCELERATES LIVER FIBROSIS AND CELL PROLIFERATION IN CCL4 INDUCED CIRRHOSIS MICE

    Shuji Terai, Naoki Yamamoto, Koichi Fujisawa, Taro Takami, Tomoaki Murata, Hiroshi Nishina, Isao Sakaida

    HEPATOLOGY   52 ( 4 )   1265A - 1266A   2010.10

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  • TRANSCATHETER ARTERIAL INFUSION CHEMOTHERAPY USING IODIZED OIL AND DEGRADABLE STARCH MICROSPHERES FOR HEPATOCELLULAR CARCINOMA

    Takahiro Yamasaki, Yohei Harima, Issei Saeki, Tsuyoshi Ishikawa, Makoto Segawa, Koichi Uchida, Shuji Terai, Isao Sakaida

    HEPATOLOGY   52 ( 4 )   1179A - 1180A   2010.10

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  • Persistent inflammation and non-alcoholic fatty liver disease

    The Cell   42 ( 11 )   454 - 458   2010.10

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  • 漢方薬(防風通聖散・大柴胡湯)による肝脂肪化・肝線維化抑制効果について

    内田 耕一, 山本 直樹, 桑代 紳哉, 大石 俊之, 寺井 崇二, 坂井田 功

    肥満研究   16 ( Suppl. )   171 - 171   2010.9

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  • 当科における肥満症に対する内視鏡的胃内バルーン留置術施行へ向けての取り組みについて

    岡本 健志, 寺井 崇二, 大石 俊之, 橋本 真一, 瀬川 誠, 内田 耕一, 坂井田 功

    肥満研究   16 ( Suppl. )   167 - 167   2010.9

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  • 大腸腺腫性病変とBMI・腹囲・体脂肪率との関係

    松永 尚治, 橋本 真一, 岡本 健志, 寺井 崇二, 坂井田 功

    肥満研究   16 ( Suppl. )   161 - 161   2010.9

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  • 隠れ肥満と大腸腫瘍性病変との関連について

    橋本 真一, 松永 尚治, 岡本 健志, 寺井 崇二, 坂井田 功

    肥満研究   16 ( Suppl. )   179 - 179   2010.9

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  • 肝硬変発癌マウスモデルにおいて自己骨髄細胞投与は肝発癌を促進させない

    高見 太郎, 寺井 崇二, 前田 雅喜, 山本 直樹, 坂井田 功

    日本消化器病学会雑誌   107 ( 臨増大会 )   A881 - A881   2010.9

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  • Disease Models

    T. Matsumoto, S. Terai, T. Oishi, S. Kuwashiro, K. Fujisawa, N. Yamamoto, Y. Fujita, Y. Hamamoto, M. Furutani-Seiki, H. Nishina, Sakaida, I

    ZEBRAFISH   7 ( 3 )   312 - 312   2010.9

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  • 肝硬変発癌マウスモデルにおいて自己骨髄細胞投与は肝発癌を促進させない(Bone marrow cell infusions do not promote DEN-induced hepatocarcinogenesis in CCl4-treated liver cirrhosis mice)

    高見 太郎, 寺井 崇二, 前田 雅喜, 山本 直樹, 坂井田 功

    日本癌学会総会記事   69回   101 - 101   2010.8

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  • Current status for autologous bone marrow cell infusion (ABMi) therapy for liver cirrhosis and failure

    Japanese journal of intensive care medicine   34 ( 5 )   379 - 384   2010.5

  • 肝再生医学 臨床応用を目指した研究の新展開 無血清培地を用いた骨髄由来肝臓修復細胞の開発

    岩本 拓也, 寺井 崇二, 高見 太郎, 山本 直樹, 坂井田 功

    肝臓   51 ( Suppl.1 )   A116 - A116   2010.4

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  • ロスバスタチンの非アルコール性脂肪性肝疾患(NAFLD)病態モデルにおける肝線維化抑制効果の検討

    山本 直樹, 高見 太郎, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   51 ( Suppl.1 )   A345 - A345   2010.4

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  • 骨髄細胞投与による肝修復機構におけるTNFαシグナルの検討

    久永 拓郎, 寺井 崇二, 岩本 拓也, 高見 太郎, 山本 直樹, 仁科 博史, 坂井田 功

    肝臓   51 ( Suppl.1 )   A260 - A260   2010.4

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  • 防風通聖散・大柴胡湯によるコリン欠乏食誘発ラット肝硬変モデルにおける肝線維化抑制及び前癌性病変発生抑制効果についての検討

    内田 耕一, 山本 直樹, 寺井 崇二, 桑代 紳哉, 大石 俊之, 山崎 隆弘, 坂井田 功

    肝臓   51 ( Suppl.1 )   A129 - A129   2010.4

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  • マウス肝硬変発癌モデルにおいて自己骨髄細胞投与は肝発癌を促進させない

    高見 太郎, 寺井 崇二, 前田 雅喜, 山本 直樹, 坂井田 功

    肝臓   51 ( Suppl.1 )   A163 - A163   2010.4

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  • ゼブラフィッシュMaidは肝腫瘍のマーカー分子である

    藤澤 浩一, 寺井 崇二, 桑代 紳哉, 松本 俊彦, 山本 直樹, 高見 太郎, 佐伯 一成, 坂井田 功

    肝臓   51 ( Suppl.1 )   A255 - A255   2010.4

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  • 新規マウスGFP陽性骨髄由来細胞ex vivo培養法の開発

    高見 太郎, 寺井 崇二, 谷本 治子, 岩本 拓也, 山本 直樹, 坂井田 功

    肝臓   51 ( Suppl.1 )   A258 - A258   2010.4

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  • 全身性疾患としての肝硬変症 合併症の新しい治療 脾臓摘出術は、肝硬変症に対する自己骨髄細胞投与療法の効果を増強する

    寺井 崇二, 岩本 拓也, 山本 直樹, 坂井田 功

    肝臓   51 ( Suppl.1 )   A54 - A54   2010.4

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  • 骨髄由来肝幹細胞の肝硬変の修復時における様々な動態と微細構造解析

    山本直樹, 寺井崇二, 岩本拓也, 高見太郎, 前田雅喜, 谷本治子, 柳井章江, 仁科博史, 篠田晃, 山崎隆弘, 坂井田功

    再生医療   9   2010

  • The currents state and future prospects of our liver regeneration therapy using autologous bone marrow cells for decompensated liver cirrhosis patients

    Taro Takami, Shuji Terai, Isao Sakaida

    JOURNAL OF PHARMACOLOGICAL SCIENCES   112   28P - 28P   2010

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  • 難治性の肝・胆道疾患に関する調査研究 自己骨髄細胞による慢性肝不全治療

    坂井田功, 寺井崇二, 山本直樹, 高見太郎, 岩本拓也

    難治性の肝・胆道疾患に関する調査研究 平成21年度 総括・分担研究報告書   2010

  • 脾臓摘出術の自己骨髄細胞投与療法(ABMi療法)に対する臨床,基礎的検討

    岩本拓也, 寺井崇二, 山本直樹, 坂井田功

    再生医療   9   2010

  • 骨髄由来培養細胞による肝線維化,肝機能改善効果についての検討

    岩本拓也, 寺井崇二, 山本直樹, 坂井田功

    再生医療   9   2010

  • 部分脾動脈塞栓術(PSE)の治療成績

    大森 薫, 浜辺 功一, 瀬川 誠, 寺井 崇二, 山崎 隆弘, 為佐 卓夫, 岡 正朗, 坂井田 功

    日本門脈圧亢進症学会雑誌   15 ( 3 )   234 - 240   2009.11

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    DOI: 10.11423/jsph.15.234

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  • ATRIAL NATRIURETIC PEPTIDE (ANP) AND C-TYPE NATRIURETIC PEPTIDE (CNP) PREVENTED LIVER FIBROSIS AND HAD THE PROTECTIVE ACTION OF LIVER

    Naoki Yamamoto, Noriko Ishigaki, Haiyan Jin, Koichi Uchida, Shuji Terai, Takahiro Yamasaki, Isao Sakaida

    HEPATOLOGY   50 ( 4 )   843A - 844A   2009.10

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  • A NOVEL TRANSARTERIAL CHEMOEMBOLIZATION USING A MIXTURE OF CISPLATIN AND IODIZED OIL, AND DEGRADABLE STARCH MICROSPHERES FOR HEPATOCELLULAR CARCINOMA: A RANDOMIZED STUDY

    Issei Saeki, Takahiro Yamasaki, Yohei Harima, Kousuke Okita, Makoto Segawa, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida

    HEPATOLOGY   50 ( 4 )   1116A - 1117A   2009.10

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  • ZEBRAFISH HOMOLOGUE OF MAID (ZHM) IS MARKER PROTEIN OF ZEBRAFISH LIVER TUMORS INDUCED BY DEN

    Koichi Fujisawa, Shuji Terai, Toshihiko Matsumoto, Shinya Kuwashiro, Issei Saeki, Taro Takami, Naoki Yamamoto, Isao Sakaida

    HEPATOLOGY   50 ( 4 )   916A - 916A   2009.10

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  • ROSUVASTATIN PREVENTS LIVER FIBROSIS AND ENZYME-ALTERED LESIONS IN RAT LIVER CIRRHOSIS INDUCED BY A CHOLINE-DEFICIENT L-AMINO ACID-DEFINED DIET

    Naoki Yamamoto, Koichi Uchida, Shuji Terai, Takahiro Yamasaki, Isao Sakaida

    HEPATOLOGY   50 ( 4 )   832A - 832A   2009.10

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  • SPLENECTOMY ENHANCES THE EFFECT OF BONE MARROW CELL INFUSION ON THE REPAIR OF THE MICROENVIRONMENT IN MICE AND PATIENTS WITH LIVER CIRRHOSIS

    Takuya Iwamoto, Shuji Terai, Naoki Yamamoto, Kaoru Omori, Takahiro Yamasaki, Isao Sakaida

    HEPATOLOGY   50 ( 4 )   642A - 643A   2009.10

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  • BORTEZIMIB SPECIFICALLY INHIBITS THE PROLIFERATION OF HEPATOCELLULAR CARCINOMA

    Issei Saeki, Shuji Terai, Koichi Fujisawa, Naoki Yamamoto, Taro Takami, Takahiro Yamasaki, Isao Sakaida

    HEPATOLOGY   50 ( 4 )   1132A - 1132A   2009.10

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  • TNF-ALPHA SIGNAL IS IMPORTANT TO REPAIR CIRRHOTIC LIVER BY BONE MARROW CELL INFUSION

    Takuro Hisanaga, Shuji Terai, Takuya Iwamoto, Taro Takami, Naoki Yamamoto, Isao Sakaida, Hiroshi Nishina

    HEPATOLOGY   50 ( 4 )   848A - 849A   2009.10

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  • THE ELECTRON MICROSCOPICAL ANALYSIS FOR CELL LINEAGE OF BONE MARROW CELL DIFFERENTIATION IN CIRRHOSIS MICE

    Naoki Yamamoto, Shuji Terai, Takuya Iwamoto, Tsuyoshi Ishikawa, Taro Takami, Kaoru Omori, Koichi Uchida, Takahiro Yamasaki, Hiroshi Nishina, Isao Sakaida

    HEPATOLOGY   50 ( 4 )   901A - 902A   2009.10

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  • MESENCHYMAL CELLS DERIVED FROM BONE MARROW CELL REDUCE LIVER FIBROSIS AND IMPROVED LIVER FUNCTION IN CCL4-TREATED CIRRHOSIS MICE

    Takuya Iwamoto, Shuji Terai, Naoki Yamamoto, Kaoru Omori, Takahiro Yamasaki, Isao Sakaida

    HEPATOLOGY   50 ( 4 )   645A - 645A   2009.10

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  • 脊髄損傷マウスに対するイヌ骨髄細胞移植の効果

    谷 健二, 浅利 祐右, 小田 康喬, 原口 友也, 山本 直樹, 寺井 崇二, 坂井田 功, 板本 和仁, 田浦 保穂

    日本獣医学会学術集会講演要旨集   148回   274 - 274   2009.9

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  • 肝線維化・発癌機構の解明 硬変肝におけるHHM(Maid)によるTGF-betaシグナルの制御の可能性について

    寺井 崇二, 山本 直樹, 坂井田 功

    肝臓   50 ( Suppl.2 )   A491 - A491   2009.9

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  • 小腸カプセル内視鏡を用いたBMIと小腸運動の関連についての検討

    橋本 真一, 寺井 崇二, 松永 尚治, 岡本 健志, 坂井田 功

    肥満研究   15 ( Suppl. )   232 - 232   2009.9

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  • 肝細胞癌の治療 2009~2011 8.治療後のフォローアップと補助療法

    山崎隆弘, 浜辺崇衣, 佐伯一成, 播磨陽平, 沖田幸祐, 寺井崇二, 坂井田功

    コンセンサス癌治療   8 ( 3 )   168 - 170   2009.8

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  • 脳症発症後、急速に脳ヘルニアを来たした非ウイルス性劇症肝炎の一例

    谷本 治子, 内田 耕一, 山本 直樹, 瀬川 誠, 川上 泰広, 山口 裕樹, 大森 薫, 石川 剛, 土屋 昌子, 寺井 崇二, 山崎 隆宏, 高木 慎太郎, 高橋 祥一, 茶山 一彰, 天野 尋暢, 大段 秀樹, 坂井田 功

    肝臓   50 ( 8 )   496 - 496   2009.8

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  • 内視鏡教育のための動画像を用いたシミュレーション型教材の評価

    小柏香穂理, 浜本義彦, 藤田悠介, 室川和也, 米田晴彦, 齋藤真理, 西川潤, 寺井崇二, 坂井田功

    医学教育   40 ( Suppl. )   57   2009.7

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  • 免疫電顕を用いた骨髄由来肝幹細胞の肝硬変の修復時の各種細胞の動態

    山本 直樹, 寺井 崇二, 岩本 拓也, 高見 太郎, 内田 耕一, 山崎 隆弘, 仁科 博史, 坂井田 功

    肝臓   50 ( Suppl.1 )   A178 - A178   2009.4

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  • 骨髄細胞投与による肝硬変症改善に係わるサイトカインの動態解析について(臨床研究および基礎研究の比較より)

    水永 裕子, 寺井 崇二, 大森 薫, 山本 直樹, 内田 耕一, 山崎 隆弘, 坂井田 功

    肝臓   50 ( Suppl.1 )   A180 - A180   2009.4

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  • 脾臓摘出術の自己骨髄細胞投与療法に対する臨床、基礎的検討 肝マクロファージから見た検討

    岩本 拓也, 寺井 崇二, 佐伯 一成, 山本 直樹, 大森 薫, 瀬川 誠, 内田 耕一, 山崎 隆弘, 坂井田 功

    肝臓   50 ( Suppl.1 )   A187 - A187   2009.4

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  • ナトリウム利尿ポリペプチド製剤による新規肝線維化抑制効果の可能性

    山本 直樹, 石垣 賀子, 寺井 崇二, 内田 耕一, 坂井田 功

    肝臓   50 ( Suppl.1 )   A220 - A220   2009.4

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  • ユビキチンプロテアソーム阻害薬Bortezomibの肝細胞癌に対する抗腫瘍効果についての検討

    佐伯 一成, 寺井 崇二, 藤澤 浩一, 高見 太郎, 山本 直樹, 山崎 隆弘, 坂井田 功

    肝臓   50 ( Suppl.1 )   A300 - A300   2009.4

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  • 骨髄細胞投与による肝修復機構におけるTNFαシグナルの関与についての検討

    久永 拓郎, 寺井 崇二, 岩本 拓也, 高見 太郎, 山本 直樹, 仁科 博史, 坂井田 功

    肝臓   50 ( Suppl.1 )   A180 - A180   2009.4

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  • 医学における画像診断教育のための学習管理機能について

    小柏香穂理, 浜本義彦, 藤田悠介, 室川和也, 米田晴彦, 齋藤真理, 西川潤, 寺井崇二, 坂井田功

    情報処理学会全国大会講演論文集   71st ( 4 )   4.405-4.406   2009.3

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  • 消化器臓器における幹細胞研究の進歩 骨髄幹細胞投与後の肝硬変症マウスにおけるクロマチンの動態変化についての検討

    寺井 崇二, 山本 直樹, 坂井田 功

    日本消化器病学会雑誌   106 ( 臨増総会 )   A68 - A68   2009.3

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  • 肝臓の基礎研究 疾患の理解と治療への応用 肝硬変に対する自己骨髄細胞投与療法

    寺井 崇二, 山本 直樹, 大森 薫, 高見 太郎, 坂井田 功

    解剖学雑誌   84 ( Suppl. )   108 - 108   2009.3

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  • Development of a Computer-Simulation Teaching Material Using Video Images for Endoscopic Education Concerning Gastric Cancer

    小柏香穂理, 浜本義彦, 藤田悠介, 室川和也, 米田晴彦, 齋藤真理, 西川潤, 寺井崇二, 坂井田功

    ITヘルスケア誌(Web)   3 ( 3 )   117-127 (J-STAGE)   2009

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  • 脾臓摘出によるABMI療法の肝線維化,肝再生効果に対する臨床,基礎的検討

    岩本拓也, 寺井崇二, 久永拓郎, 佐伯一成, 水永裕子, 山本直樹, 坂井田功

    再生医療   8   2009

  • 骨髄中の肝幹細胞の動態と微細構造解析-GFP/CCl4モデル-

    山本直樹, 寺井崇二, 柳井章江, 篠田晃, 仁科博史, 坂井田功

    再生医療   8   2009

  • 肝硬変症に対するラエンネックの肝機能改善効果に対する検討

    久永拓郎, 寺井崇二, 岩本拓也, 山本直樹, 坂井田功

    再生医療   8   2009

  • NO.3 ファイブロスキャンによる食道静脈瘤存在予測の検討(一般演題,講演抄録,第111回山口大学医学会学術講演会)

    瀬川 誠, 寺井 崇二, 山崎 隆弘, 坂井田 功

    山口医学   57 ( 6 )   223 - 223   2008.12

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  • 【再生医療 臨床応用が進む細胞治療】 自己骨髄細胞を用いた肝臓再生

    久永 拓郎, 寺井 崇二, 坂井田 功

    Clinical Engineering   20 ( 1 )   27 - 33   2008.12

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  • ファイブロスキャンによる食道静脈瘤存在予測の検討 Invited

    瀬川 誠, 寺井 崇二, 浜辺 功一, 大石 俊之, 岩本 拓也, 桑代 紳哉, 大森 薫, 山崎 隆弘, 坂井田 功

    日本門脈圧亢進症学会雑誌   14 ( 1 )   90 - 90   2008.10

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  • 当科における食道胃静脈瘤に対する予防的治療の成績

    浜辺 功一, 大森 薫, 大石 俊之, 久永 拓郎, 岩本 拓也, 桑代 紳哉, 瀬川 誠, 寺井 崇二, 山崎 隆弘, 吉田 智治, 坂井田 功

    日本門脈圧亢進症学会雑誌   14 ( 1 )   96 - 96   2008.10

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  • ATRIAL NATRIURETIC PEPTIDE(ANP)AND C-TYPE NATRIURETIC PEPTIDE(CNP)PREVENTED LIVER FIBROSIS IN RAT MODEL USING NEW TREATMENT SYSTEM

    Naoki Yamamoto, Noriko Ishigaki, Haiyan Jin, Koichi Uchida, Shuji Terai, Isao Sakaido

    HEPATOLOGY   48 ( 4 )   923A - 923A   2008.10

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  • ABMI THERAPY COMBINED WITH SPLENECTOMY IS AN EFFECTIVE FOR LIVER CIRRHOSIS

    Takuya Iwamoto, Shuji Terai, Issei Saeki, Yuko Mizunago, Naoki Yamamoto, Isao Sakaida

    HEPATOLOGY   48 ( 4 )   544A - 544A   2008.10

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  • HERBAL MEDICINE DAI-SAIKO-TO(TJ-8)PREVENTS LIVER FIBROSIS AND ENZYME-ALTERED LESIONS IN RAT LIVER CIRRHOSIS INDUCED BY A CHOLINE-DEFICIENT L-AMINO ACID-DEFINED DIET

    Koichi Uchida, Naoki Yamamoto, Hoiyan Jin, Shuji Terai, Isao Sakaida

    HEPATOLOGY   48 ( 4 )   926A - 926A   2008.10

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  • HERBAL MEDICINE BOFU-TSUSHO-SAN (TJ-62) PREVENTS LIVER FIBROSIS AND ENZYME-ALTERED LESIONS IN RAT LIVER CIRRHOSIS INDUCED BY A CHOLINE-DEFICIENT L-AMINO ACID-DEFINED DIET

    Koichi Uchida, Naoki Yamamoto, Haiyan Jin, Shuii Terai, Isoo Sakaida

    HEPATOLOGY   48 ( 4 )   925A - 925A   2008.10

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  • G-CSF IS A CANDIDATE SERUM MARKER FOR ABMI THERAPY FOR LIVER CIRRHOSIS PATIENT

    Yuko Mizunaga, Shuji Terai, Kaoru Omori, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Isao Sakaida

    HEPATOLOGY   48 ( 4 )   644A - 644A   2008.10

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  • ZEBRAFISH HOMOLOGUE OF MAID (ZHM) SPECIFICALLY REGULATES CELL PROLIFERATION IN LIVER REGENERATION AND HEPATOCARCINIOGENESIS

    Koichi Fujisawa, Shuji Terai, Toshihiko Matsumoto, Shinya Kuwashiro, Taro Takami, Naoki Yamamoto, Isao Sakoida

    HEPATOLOGY   48 ( 4 )   1119A - 1119A   2008.10

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  • Maidは細胞増殖の制御分子である(Maid is involved in cell cycle control in zebraflsh liver)

    藤澤 浩一, 寺井 崇二, 松本 俊彦, 山本 直樹, 坂井田 功

    日本癌学会総会記事   67回   158 - 158   2008.9

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  • Bortezomibは肝癌培養細胞株において、HHMの発現を亢進して増殖を抑制する(Bortezomib inhibit the proliferation of hepatocellular carcinoma cell line with the activation of HHM expression)

    佐伯 一成, 寺井 崇二, 藤澤 浩一, 山本 直樹, 高見 太郎, 坂井田 功

    日本癌学会総会記事   67回   76 - 76   2008.9

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  • No.14 出血性ストーマ静脈瘤に対して硬化療法が有効であった1例(一般演題,第110回山口大学医学会学術講演会並びに平成20年度山口大学医学会総会)

    大石 俊之, 内田 耕一, 大森 薫, 瀬川 誠, 寺井 崇二, 山崎 隆弘, 坂井田 功

    山口医学   57 ( 2 )   65 - 66   2008.6

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  • 肝不全における臨床と研究の新展開 脾臓摘出術併用骨髄細胞投与による肝硬変の改善の検討

    岩本 拓也, 寺井 崇二, 佐伯 一成, 水永 裕子, 大森 薫, 山本 直樹, 篠田 晃, 坂井田 功

    肝臓   49 ( Suppl.1 )   A53 - A53   2008.4

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  • 当科における肝硬変の成因別実態

    瀬川 誠, 寺井 崇二, 播磨 洋平, 藤澤 浩一, 佐伯 一成, 桑代 紳哉, 岩本 拓也, 水永 裕子, 松本 俊彦, 仁科 惣治, 播磨 夕美子, 大森 薫, 山本 直樹, 山口 裕樹, 内田 耕一, 是永 圭子, 是永 匡紹, 山崎 隆弘, 坂井田 功

    肝臓   49 ( Suppl.1 )   A106 - A106   2008.4

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  • 当科における近年の薬物性肝障害の動向について

    瀬川 誠, 寺井 崇二, 播磨 洋平, 藤澤 浩一, 佐伯 一成, 桑代 紳哉, 岩本 拓也, 水永 裕子, 松本 俊彦, 仁科 惣治, 播磨 夕美子, 大森 薫, 山本 直樹, 山口 裕樹, 内田 耕一, 是永 圭子, 是永 匡紹, 山崎 隆弘, 坂井田 功

    肝臓   49 ( Suppl.1 )   A119 - A119   2008.4

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  • GFP/CCl4モデルにおける骨髄由来肝幹細胞の動態と微細構造の解析

    山本 直樹, 寺井 崇二, 岩本 拓也, 内田 耕一, 山崎 隆弘, 仁科 博史, 坂井田 功

    肝臓   49 ( Suppl.1 )   A230 - A230   2008.4

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  • ユビキチンプロテオソーム阻害薬Bortezomibの肝細胞癌培養細胞株に対する抗腫瘍効果についての検討

    佐伯 一成, 寺井 崇二, 岩本 拓也, 金 海燕, 内田 耕一, 山本 直樹, 山崎 隆弘, 坂井田 功

    肝臓   49 ( Suppl.1 )   A240 - A240   2008.4

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  • Maidは細胞増殖の制御分子である

    藤澤 浩一, 寺井 崇二, 桑代 紳哉, 松本 俊彦, 山本 直樹, 坂井田 功

    肝臓   49 ( Suppl.1 )   A242 - A242   2008.4

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  • メダカNASHモデルを用いたTelmisartanの効果検討

    桑代 紳哉, 寺井 崇二, 藤澤 浩一, 松本 俊彦, 山本 直樹, 坂井田 功

    肝臓   49 ( Suppl.1 )   A381 - A381   2008.4

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  • ナトリウム利尿ポリペプチド製剤による肝線維化抑制効果についての検討

    山本 直樹, 金 海燕, 石垣 賀子, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   49 ( Suppl.1 )   A395 - A395   2008.4

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  • GFP/CCl4モデルにおける骨髄細胞投与による肝再生過程におけるサイトカインの関与についての検討

    水永 裕子, 寺井 崇二, 岩本 拓也, 金 海燕, 山本 直樹, 坂井田 功

    肝臓   49 ( Suppl.1 )   A395 - A395   2008.4

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  • Loss of hepatocyte growth factor/c-met signaling pathway accelerates early stages of DEN-induced hepatocarcinogenesis

    TAKAMI Taro, UCHIDA Koichi, TERAI Shuji, FACTOR Valentina M., SAKAIDA Isao, THORGEIRSSON Snorri S.

    105   A23   2008.3

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  • eラーニングによる内視鏡教育のためのバーチャル診断システムの試作

    小柏香穂理, 浜本義彦, 藤田悠介, 室川和也, 杉井学, 西川潤, 寺井崇二, 坂井田功

    情報処理学会全国大会講演論文集   70th ( 4 )   4.475-4.476   2008.3

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  • ナトリウム利尿ポリペプチド製剤による肝線維化抑制効果についての検討

    山本 直樹, 寺井 崇二, 金 海燕, 石垣 賀子, 内田 耕一, 山崎 隆弘, 坂井田 功

    日本消化器病学会雑誌   105 ( 臨増総会 )   A257 - A257   2008.3

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  • 骨髄細胞から肝細胞への分化過程におけるサイトカインの動態解析 GFP/CCl4モデルの解析より

    水永 裕子, 寺井 崇二, 岩本 拓也, 大森 薫, 山本 直樹, 内田 耕一, 山崎 隆弘, 坂井田 功

    日本消化器病学会雑誌   105 ( 臨増総会 )   A335 - A335   2008.3

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  • The pilot study: A novel transarterial chemoembolization using degradable starch microspheres for hepatocellular carcinoma

    Yamasaki, T., Saeki, I., Harima, Y., Okita, K., Segawa, M., Yamaguchi, Y., Korenaga, K., Korenaga, M., Uchida, K., Terai, S., Sakaida, I.

    Kanzo/Acta Hepatologica Japonica   49 ( 1 )   25 - 27   2008.1

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    DOI: 10.2957/kanzo.49.25

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  • 肝硬変症に対する自己骨髄細胞投与療法

    寺井崇二, 岩本拓也, 水永裕子, 大森薫, 山本直樹, 坂井田功

    再生医療   7   2008

  • 脾臓摘出術併用骨髄細胞投与による肝硬変の改善の検討

    岩本拓也, 寺井崇二, 佐伯一成, 水永裕子, 山本直樹, 篠田晃, 坂井田功

    再生医療   7   2008

  • GFP/CCl4モデルにおける骨髄由来細胞の微細構造の解析

    山本直樹, 寺井崇二, 柳井章枝, 岩本拓也, 篠田晃, 仁科博史, 坂井田功

    再生医療   7   2008

  • 肝臓病の最新治療--慢性肝不全に対する自己骨髄細胞投与療法 (肝臓病のすべて) -- (肝臓病の治療)

    岩本 拓也, 寺井 崇二, 坂井田 功

    からだの科学   ( 258 )   141 - 148   2008

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    Other Link: http://search.jamas.or.jp/link/ui/2008258081

  • 心房性ナトリウム利尿ペプチド(ANP)による肝線維化抑制効果の検討

    石垣 賀子, 山本 直樹, 金 海燕, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    山口医学   56 ( 6 )   225 - 225   2007.12

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  • 再生医療最前線 骨髄幹細胞を用いた肝臓再生療法の開発の試み 臨床研究の状況の概説

    寺井 崇二, 岩本 拓也, 水永 裕子, 大森 薫, 山本 直樹, 坂井田 功

    再生医療   6 ( 4 )   381 - 384   2007.11

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  • 肝硬変患者におけるファイブロスキャンによる肝弾性値測定の有用性

    瀬川 誠, 寺井 崇二, 大森 薫, 山本 直樹, 山口 裕樹, 是永 圭子, 内田 耕一, 是永 匡紹, 山崎 隆弘, 坂井田 功

    肝臓   48 ( Suppl3 )   A528 - A528   2007.11

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  • 当科で経験した肝血管肉腫の2症例

    岩本 拓也, 瀬川 誠, 藤沢 浩一, 播磨 陽平, 佐伯 一成, 桑代 紳哉, 水永 裕子, 仁科 惣治, 松本 俊彦, 播磨 夕美子, 大森 薫, 嶋田 正勝, 高見 太郎, 山本 直樹, 山口 裕樹, 是永 匡紹, 是永 圭子, 内田 耕一, 寺井 崇二, 山崎 隆弘, 坂井田 功

    肝臓   48 ( Suppl3 )   A634 - A634   2007.11

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  • Current status of liver function evaluation using Transient Elastography (FibroScan) and its potential application for diagnosis of portal hypertension Invited

    Makoto Segawa, Shuji Terai, Tomoharu Yoshida, Isao Sakaida

    Japanese Journal of Portal Hypertension and Esophageal Varices   13 ( 3 )   192 - 196   2007.11

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    DOI: 10.11423/jsph1999.13.3_192

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  • Current status of autologous bone marrow cell infusion (ABMI) therapy for liver cirrhosis patients

    Shuji Terai, Yoshio Marumoto, Yohei Urata, Takuya Iwamoto, Yuko Mizunaga, Toshihiko Matsumoto, Kaoru Omori, Naoki Yamamoto, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22   A183 - A183   2007.10

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  • Telmisartain prevents hepatic fibrosis and enzyme-altered preneoplastic lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet

    Haiyan Jin, Naoki Yamamoto, Shuji Terai, Fujio Murakami, Isao Sakaida

    HEPATOLOGY   46 ( 4 )   718A - 718A   2007.10

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  • Long time follow up for the patient of autologous bone marrow cell infusion (ABMI) therapy for liver cirrhosis

    Shuji Terai, Makoto Segawa, Kaoru Omori, Takuya Iwamoto, Yuko Mizunaga, Toshihiko Matsumoto, Yohei Urata, Yoshio Marumoto, Tsuyoshi Ishikawa, Naoki Yamamoto, Koichi Uchida, Takahiro Yamasaki, Isao Sakaida

    HEPATOLOGY   46 ( 4 )   246A - 247A   2007.10

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  • Natriuretic peptide improved liver fibrosis in rat model using new treatment system

    Naoki Yamamoto, Noriko Ishigaki, Haiyan Jin, Kouichi Uchida, Shuji Terai, Isao Sakaida

    HEPATOLOGY   46 ( 4 )   719A - 719A   2007.10

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  • Atrial natriuretic peptide (ANP) prevented liver fibrosis in rat using new treatment system

    Noriko Ishigaki, Naoki Yamamoto, Haiyan Jin, Koichi Uchida, Shuji Terai, Isao Sakaida

    HEPATOLOGY   46 ( 4 )   872A - 872A   2007.10

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  • Analysis for the mechanism of NASH using high fat diet medaka fish model

    Shuji Terai, Toshihiko Matsumoto, Koichi Fujisawa, Isao Sakaida

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   22   A182 - A182   2007.10

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  • B型重症肝不全の病態と治療 当科におけるB型重症肝不全に対する治療法の現況

    内田 耕一, 山本 直樹, 大森 薫, 瀬川 誠, 播磨 夕美子, 松本 俊彦, 水永 裕子, 播磨 陽平, 佐伯 一成, 桑代 紳哉, 岩本 拓也, 寺井 崇二, 坂井田 功

    肝臓   48 ( 8 )   399 - 399   2007.8

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  • NO.12肝性脳症,異常行動時の脳内神経性アミノ酸,脳組織学的変化の検討 : 急性肝不全肝性脳症モデル(一般演題,第108回山口大学医学会学術講演会並びに平成19年度総会)

    播磨 夕美子, 寺井 崇二, 三浦 泉, 篠田 晃, 坂井田 功

    山口医学   56 ( 3 )   94 - 94   2007.6

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  • 慢性肝不全 5 自己骨髄細胞投与療法の開発

    寺井崇二, 浦田洋平, 丸本芳雄, 水永裕子, 松本俊彦, 山本直樹, 坂井田功

    治療学   41 ( 4 )   382 - 386   2007.4

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  • 肝硬変症に対する自己骨髄細胞投与療法の現状および今後の展望について

    寺井 崇二, 浦田 洋平, 丸本 芳雄, 松本 俊彦, 山本 直樹, 是永 圭子, 内田 耕一, 山崎 隆弘, 坂井田 功

    肝臓   48 ( Suppl.1 )   A49 - A49   2007.4

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  • メダカモデルを用いた肝線維化モデルの作成と検討

    松本 俊彦, 寺井 崇二, 藤澤 浩一, 山本 直樹, 坂井田 功

    肝臓   48 ( Suppl.1 )   A77 - A77   2007.4

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  • GFP/CCl4モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析

    山本 直樹, 寺井 崇二, 丸本 芳雄, 内田 耕一, 山崎 隆弘, 仁科 博史, 坂井田 功

    肝臓   48 ( Suppl.1 )   A118 - A118   2007.4

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  • Beta-cateninは骨髄細胞から肝細胞への分化制御に重要な役割を担う

    丸本 芳雄, 寺井 崇二, 松本 俊彦, 水永 裕子, 浦田 洋平, 山本 直樹, 坂井田 功

    肝臓   48 ( Suppl.1 )   A121 - A121   2007.4

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  • ナトリウム利尿ポリペプチド製剤による肝線維化抑制効果についての検討

    山本 直樹, 寺井 崇二, 金 海燕, 石垣 賀子, 内田 耕一, 山崎 隆弘, 坂井田 功

    肝臓   48 ( Suppl.1 )   A246 - A246   2007.4

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  • テルミサルタンのCholine-deficient L-amino acid-defined(CDAA)-dietラットモデルにおける肝線維化抑制効果の検討

    金 海燕, 山本 直樹, 内田 耕一, 寺井 崇二, 坂井田 功

    肝臓   48 ( Suppl.1 )   A250 - A250   2007.4

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  • What’s New in SURGERY FRONTIER 第52回 幹細胞と癌 3 肝幹細胞の分化を制御するhuman homologue of maid(HHM)の視点から考えた肝発癌制御機構について

    寺井崇二, 松本俊彦, 藤澤浩一, 横山雄一郎, 高見太郎, 坂井田功

    Surg Front   14 ( 1 )   88 - 94   2007.3

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  • Therapeutic strategy for liver fibrosis

    松本俊彦, 寺井崇二, 坂井田功

    肝胆膵   54 ( 1 )   57 - 62   2007.1

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  • 肝硬変症に対する自己骨髄細胞投与療法の現状および今後の展望について

    寺井崇二, 浦田洋平, 丸本芳雄, 松本俊彦, 山本直樹, 阪井田功

    再生医療   6   2007

  • 肝硬変症に対する自己骨髄細胞投与療法の現状および今後の展望について

    寺井崇二, 浦田洋平, 丸本芳雄, 松本俊彦, 山本直樹, 坂井田功

    再生医療   6   2007

  • GFP/CCl4モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析

    山本直樹, 寺井崇二, 柳井章江, 仁科博史, 篠田晃, 坂井田功

    再生医療   6   2007

  • C-1 ペグインターフェロン併用動注化学療法にて著効を示した進行肝細胞癌の1例(Clinical Section,一般演題,講演抄録,第107回山口大学医学会学術講演会)

    浜辺 功一, 山崎 隆弘, 松本 賢治, 沖田 幸祐, 山口 裕樹, 是永 圭子, 是永 匡紹, 内田 耕一, 寺井 崇二, 為佐 卓夫, 坂井田 功, 岡 正朗

    山口医学   55 ( 6 )   204 - 205   2006.12

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  • 多施設臨床研究:肝硬変症に対するABMI療法の開発

    寺井崇二, 浦田洋平, 丸本芳雄, 石川剛, 青山浩司, 大森薫, 山本直樹, 坂井田功, 仁科博史, 奥本和夫, 斎藤貴史, 河田純男, 沖田極

    再生医療   5 ( 4 )   535-543,469-470   2006.11

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  • Improved liver function in liver cirrhosis patients after autologous bone marrow cell infusion (ABMI) therapy

    Shuji Terai, Tsuyoshi Ishikawa, Kaoru Omori, Koji Aoyama, Yoshio Marumoto, Yohei Urata, Yuichirou Yokoyama, Koichi Uchida, Takahiro Yamasaki, Yasuhiko Fujii, Kiwamu Okita, Isao Sakaida

    HEPATOLOGY   44 ( 4 )   402A - 402A   2006.10

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  • Development of a new NASH model using Medaka fish

    Toshihiko Matsumoto, Shuji Terai, Yoshio Marumoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida

    HEPATOLOGY   44 ( 4 )   663A - 664A   2006.10

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  • Iron chelator deferoxamine induced activated hepatic stellate cells into the quiescent state and apoptosis

    Haiyan Jin, Shuji Terai, Isao Sakaida

    HEPATOLOGY   44 ( 4 )   684A - 684A   2006.10

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  • Cytokines : Regulator for Non-alcoholic steatohepatitis (NASH)

    松本俊彦, 寺井崇二, 坂井田功

    肝胆膵   53 ( 3 )   341 - 347   2006.9

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  • 炎症性腸疾患の人大腸粘膜の局所組織におけるMatrix metalloproteinase-9の発現

    原田 克則, 寺井 崇二, 桧垣 真吾, 橋本 一夫, 天野 文香, 橋本 真一, 坂井田 功

    日本消化器病学会雑誌   103 ( 臨増大会 )   A851 - A851   2006.9

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  • 当科における急性肝不全に対する治療法の現況

    内田 耕一, 丸本 芳雄, 浦田 洋平, 磯辺 夕美子, 松本 俊彦, 水永 裕子, 瀬川 誠, 山本 直樹, 寺井 崇二, 坂井田 功

    肝臓   47 ( 7 )   366 - 366   2006.7

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  • 進行肝癌に対する動注化学療法の果たす役割と問題点

    山崎隆弘, 山口裕樹, 是永圭子, 是永匡紹, 内田耕一, 寺井崇二, 黒川典枝, 坂井田功

    肝臓   47 ( Supplement 1 )   A253   2006.4

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  • Development of an in vivo animal model to monitor the extracellular neural amino acid in brain during behavior disorder at acute liver failure

    Miura, I, Y Isobe, S Terai, Sakaida, I

    JOURNAL OF PHARMACOLOGICAL SCIENCES   100   89P - 89P   2006

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  • 幹細胞による肝再生とその臨床応用

    沖田極, 坂井田功, 寺井崇二, 山本直樹, 大森薫, 石川剛, 青山浩司

    日本内科学会雑誌   95   2006

  • NO.6 メダカを用いた新規脂肪肝モデルの作成と, 脂肪肝形成過程における遺伝子発現の検討(第105回山口大学医学会学術講演会)

    松本 俊彦, 寺井 崇二, 仁科 博史, 坂井 田功

    山口医学   54 ( 6 )   189 - 189   2005.12

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  • 進行肝癌に対する動注化学療法の現状と問題点

    山崎隆弘, 寺井崇二, 坂井田功

    Biotherapy (Tokyo)   19 ( Supplement 1 )   59   2005.10

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  • Development of an in vivo animal model to monitor the extracellular neural amino acids in the dorsal hippocampus during behavior disorder on acute liver failure

    Y Isobe, Miura, I, S Terai, Sakaida, I, K Okita

    HEPATOLOGY   42 ( 4 )   355A - 355A   2005.10

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  • ER stress is important to regulate the differentiation of bone marrow cell into hepatocyte in GFP/CCL4 model

    Y Marumoto, S Terai, T Matumoto, T Ishikawa, K Aoyama, Sakaida, I, H Nishina, K Okita

    HEPATOLOGY   42 ( 4 )   372A - 372A   2005.10

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  • Matrix-related gene expression in the bone marrow transplantation in CCL4-induced liver fibrosis

    K Aoyama, Sakaida, I, Y Urata, Y Marumoto, T Ishikawa, S Terai, K Okita

    HEPATOLOGY   42 ( 4 )   738A - 739A   2005.10

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  • Sialylated apolipoprotein e increased in human hepatocellular carcinoma

    K. Nakamura, Y. Yokoyama, Y. Kuramitsu, M. Takashima, N. Iizuka, S. Terai, I. Sakaida, M. Oka, K. Okita

    MOLECULAR & CELLULAR PROTEOMICS   4 ( 8 )   S74 - S74   2005.8

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  • 肝細胞癌患者における血清中の自己抗HHM(Human Homologue of Maid)抗体の検出

    横山雄一郎, 寺井崇二, 高見太郎, 田島邦彦, 谷本治子, 山崎隆弘, 黒川典枝, 坂井田功, 沖田極

    肝臓   46 ( Supplement 1 )   A132   2005.5

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  • NO.11 骨髄細胞から肝細胞への分化過程における線維芽細胞増殖因子の促進効果(一般演題)(第103回山口大学医学会学術講演会)

    石川 剛, 寺井 崇二, 磯部 夕美子, 松本 俊彦, 浦田 洋平, 丸本 芳雄, 青山 浩司, 大森 薫, 坂井田 功, 沖田 極

    山口医学   53 ( 6 )   336 - 336   2004.12

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  • Fibroblast growth factors enhance the repopulation and differentiation of bone marrow cells into hepatocytes.

    T Ishikawa, S Terai, Y Urata, Y Marumoto, K Aoyama, K Omori, Sakaida, I, H Nishina, K Okita

    HEPATOLOGY   40 ( 4 )   380A - 381A   2004.10

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  • Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells.

    Sakaida, I, JH Shen, K Uchida, K Aoyama, T Ishikawa, S Terai, K Okita

    HEPATOLOGY   40 ( 4 )   196A - 197A   2004.10

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  • Proteomic analysis of serum proteins in carbon tetrachloride treated mice transplanted bone marrow cells.

    Y Yokoyama, S Terai, K Omori, K Aoyama, T Ishikawa, T Takami, Sakaida, I, H Nishina, K Okita

    HEPATOLOGY   40 ( 4 )   382A - 382A   2004.10

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  • The effect of a late evening snack in patients with liver cirrhosis.

    Sakaida, I, M Tsuchiya, M Okamoto, S Terai, K Okita

    HEPATOLOGY   40 ( 4 )   632A - 632A   2004.10

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  • 肝細胞癌に対するリピオドール併用肝動脈バルーン閉塞下ラジオ波凝固療法

    山崎隆弘, 木村輝昭, 山口裕樹, 寺井崇二, 黒川典枝, 坂井田功, 沖田極

    肝臓   45 ( Supplement 2 )   A491   2004.9

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  • 進行肝癌の予後改善策 進行肝癌に対する動注化学療法の現状と展望

    山崎隆弘, 木村輝昭, 寺井崇二, 黒川典枝, 坂井田功, 沖田極

    月刊消化器科   39 ( 2 )   185 - 191   2004.8

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  • 劇症肝炎時におけるアポトーシス誘導因子であるチトクロームC血清中濃度の臨床的検討

    木村輝昭, 坂井田功, 大森薫, 川口浩太郎, 土屋昌子, 高見太郎, 山本直己, 寺井崇二, 山崎隆弘

    肝臓   44 ( 11 )   614   2003.11

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  • EBMに基づいた肝細胞癌の治療 進行肝細胞癌に対するlow dose FPのBiochemical modulator併用による動注化学療法の有用性

    弘中孝治, 山崎隆弘, 木村輝昭, 寺井崇二, 黒川典枝, 坂井田功, 沖田極

    月刊消化器科   37 ( 4 )   427 - 432   2003.10

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  • Transplantation of Liv-8 negative fraction of bone marrow cells reverses CCL4-induced liver fibrosis.

    Sakaida, I, K Aoyama, N Yamamoto, T Ishikawa, K Omori, S Terai, H Nishina, K Okita

    HEPATOLOGY   38 ( 4 )   223A - 223A   2003.10

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  • Leptin receptor-deficient Zucker (fa/fa) rat retards the development of pig serum-induced liver fibrosis with Kupffer cell dysfunction.

    Sakaida, I, K Uchida, S Terai, K Okita

    HEPATOLOGY   38 ( 4 )   191A - 191A   2003.10

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  • Cytochrome-C is the possible new marker for the patients with acute liver failure.

    Sakaida, I, T Kimura, K Omori, S Terai, K Okita

    HEPATOLOGY   38 ( 4 )   554A - 554A   2003.10

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  • Fibroblast growth factors enhance the trans-differentiation and proliferation of bone mallow cells into hepatocytes.

    T Ishikawa, S Terai, K Aoyama, K Omori, Sakaida, I, H Nishina, K Okita

    HEPATOLOGY   38 ( 4 )   166A - 166A   2003.10

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  • Practice of the pharmacotherapy in the each organ cancer. Continuance arterial injection chemotherapy for liver cancer and progressive liver cancer.

    山崎隆弘, 木村輝昭, 高見太郎, 大森薫, 川口浩太郎, 土屋昌子, 山本直樹, 岡本真理子, 寺井崇二

    月刊臨床と研究   80 ( 7 )   1227 - 1233   2003.7

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  • HHMは肝発癌の初期に誘導され増殖を促進する

    高見太郎, 寺井崇二, 横山雄一郎, 田島邦彦, 谷本浩子, 山本直樹, 木村輝昭, 宮本康嗣, 山崎隆弘

    肝臓   44 ( Supplement 1 )   A169 - A169   2003.4

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  • VI. 肝臓 6. 肝細胞癌の病態と診断

    高見太郎, 寺井崇二, 山崎隆弘, 坂井田功, 沖田極

    Annual Review 消化器   2003   285 - 288   2003.1

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  • A new cell therapy using bone marrow cell to repair damaged liver.

    寺井崇二, 山本直樹, 大森薫, 坂井田功, 沖田極

    肝胆膵   46 ( 3 )   2003

  • FGFは骨髄細胞の肝細胞への分化・増殖を促進する

    石川剛, 寺井崇二, 青山浩司, 大森薫, 山本直樹, 坂井田功, 沖田極

    肝臓   44 ( Supplement 1 )   2003

  • 骨髄細胞から肝細胞への分化に関与する遺伝子群についての解析

    大森薫, 寺井崇二, 松本しのぶ, 石川剛, 青山浩司, 山本直樹, 坂井田功, 仁科博史, 沖田極

    肝臓   44 ( Supplement 1 )   2003

  • Transplantation of bone marrow cells reverses CCL4-induced liver fibrosis.

    Sakaida, I, S Terai, N Yamamoto, K Kawaguchi, M Tsuchiya, T Takami, K Uchida, K Okita

    HEPATOLOGY   36 ( 4 )   295A - 295A   2002.10

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  • HHM : A dominant inhibitory HLH protein, which regulates liver carcinogenesis.

    T Takami, S Terai, K Kawaguchi, H Tamimoto, M Tsuchiya, K Omori, N Yamamoto, K Miyamoto, K Uchida, T Yamasaki, F Kurokawa, Sakaida, I, H Nishina, SS Thorgeirsson, K Okita

    HEPATOLOGY   36 ( 4 )   448A - 448A   2002.10

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  • Expression of helix-loop-helix transcription factor in rat hepatic stellate cell.

    K Kawaguchi, Sakaida, I, S Terai, M Tsuchiya, K Omori, T Takami, N Yamamoto, M Okamoto, K Uchida, SS Thorgeirsson, K Okita

    HEPATOLOGY   36 ( 4 )   439A - 439A   2002.10

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  • Gene expression profile which regulates the differentiation of bone marrow cell into hepatocyte in GFP/CCL4 model.

    K Omori, S Terai, N Yamamoto, K Kawaguchi, T Takami, M Tuchiya, K Miyamoto, K Uchida, Sakida, I, S Ohata, T Watanabe, H Nishina, SS Thorgeirsson, K Okita

    HEPATOLOGY   36 ( 4 )   199A - 199A   2002.10

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  • LIV8 MAB: A new murine monoclonal antibody separate hepatic stem cell population in bone marrow.

    N Yamamoto, S Terai, K Omori, K Kawaguchi, T Takami, M Tsuchiya, K Uchida, K Miyamoto, Sakaida, I, S Thorgeirsson, H Nishina, K Okita

    HEPATOLOGY   36 ( 4 )   200A - 200A   2002.10

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  • Regulation of collagen and matrix metalloproteinase expression by map kinase signal pathway in stellate cell

    M Tuchiya, Sakaida, I, K Omori, K Kawaguchi, T Takami, N Yamamoto, M Okamoto, K Uchida, S Terai, K Okita

    HEPATOLOGY   36 ( 4 )   262A - 262A   2002.10

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  • Herbal medicine inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid defined diet.

    Sakaida, I, S Terai, N Yamamoto, K Omori, K Kawaguchi, M Tsuchiya, T Takami, K Uchida, K Okita

    HEPATOLOGY   36 ( 4 )   252A - 252A   2002.10

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  • 肝細胞癌の病態と新しい治療戦略 肝細胞癌の血流コントロール下RFAによる治療戦略の展開

    山崎隆弘, 黒川典枝, 高見太郎, 山本直樹, 木村輝昭, 寺井崇二, 坂井田功, 沖田極

    消化器画像   4 ( 4 )   431 - 436   2002.7

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  • 消化器の再生医学の現状 骨髄細胞を用いた肝臓再生療法の基礎的検討

    寺井 崇二, 山本 直樹, 沖田 極

    日本消化器病学会雑誌   99 ( 臨増総会 )   A109 - A109   2002.3

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  • 肝細胞癌破裂における肝動脈塞栓術(TAE)の意義

    山本直樹, 山崎隆弘, 高見太郎, 川口浩太郎, 大森薫, 寺井崇二, 黒川典枝, 坂井田功, 沖田極

    日本腹部救急医学会雑誌   22 ( 2 )   356   2002.2

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  • 骨髄細胞を用いた肝臓再生療法開発のためのストラテジー

    寺井崇二, 山本直樹, 沖田極

    肝臓   43 ( Supplement 2 )   2002

  • p38 MAP kinase regulates the production of type IV collagenase in human hepatic stellate cell line L190 and hepatic adenocarcinoma cell line SK-HEP-1.

    M Segawa, Sakaida, I, S Terai, M Aoyagi, E Sakaguchi, K Kayano, K Okita

    HEPATOLOGY   34 ( 4 )   497A - 497A   2001.10

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  • TGF-beta2 suppressed Th1-type cytokines, production at the single-cell level in HCV-related liver cirrhosis.

    E Sakaguchi, K Kayano, M Segawa, M Okamoto, Sakaida, I, N Yamamoto, S Terai, K Okita

    HEPATOLOGY   34 ( 4 )   515A - 515A   2001.10

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  • Development of new regenerative model: Transplanted GFP positive bone marrow cell migrated into damaged area and differentiated into hepatocyte.

    S Terai, N Yamamoto, Sakaida, I, E Sakaguchi, K Miyamoto, K Okita

    HEPATOLOGY   34 ( 4 )   235A - 235A   2001.10

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  • HHM: A new dominant inhibitory HLH protein which is associated with liver carcinogenesis.

    S Terai, Sakaida, I, H Shirahashi, K Uchida, N Yamamoto, K Miyamoto, SS Thorgeirsson, K Okita

    HEPATOLOGY   34 ( 4 )   499A - 499A   2001.10

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  • A new tumor marker for human hepatocellular carcinoma: 8-hydoxy-deoxyguanosine (8-OHdG) elevated in adenomatous hyperplasia(dysplastic nodule, low grade).

    K Uchida, Sakaida, I, H Shirahashi, S Terai, K Okita

    HEPATOLOGY   34 ( 4 )   671A - 671A   2001.10

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  • 肝細胞癌におけるHHM蛋白の発現の検討

    寺井崇二, 白橋斉, 坂井田功, 山崎隆弘, 黒川典枝, 宮本康嗣, 沖田極

    肝臓   42 ( Supplement 1 )   A212   2001.4

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  • Regenerative medicine in liver and pancreas. A dominant inhibitory HLH protein associated with liver stem cell.

    寺井崇二, THORGEIRSSON S S, 白橋斉, 山本直樹, 谷本治子, 宮本康嗣, 沖田極

    肝胆膵   42 ( 2 )   2001

  • 肝発癌に関与する新規HLH型転写制御分子HHM

    寺井崇二, 坂井田功, 山本直樹, 白橋斉, 内田耕一, 宮本康嗣, 沖田極

    日本癌学会総会記事   60th   2001

  • 自己肝幹細胞を用いた肝臓再生療法の開発を目指して GFP transgenic mouseを用いたモデルの開発

    寺井崇二, 山本直樹, 沖田極

    日本消化器病学会雑誌   98   2001

  • 活性酸素による培養ラット星細胞活性化におけるシグナル伝達について

    内田 耕一, 坂井田 功, 萱野 幸三, 寺井 崇二, 弘中 孝治, 鈴木 千衣子, 久保 善嗣, 沖田 極

    岡山醫學會雜誌   111 ( 3 )   159 - 160   1999.8

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  • Does cytoplasmic cyclin D1 regulate the cell cycle directly?

    S Terai, K Okita

    JOURNAL OF GASTROENTEROLOGY   34 ( 4 )   547 - 548   1999.8

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  • Anti-tumor effect of vesnarinone on human hepatocellular carcinoma cell lines

    K Kubo, Y Matuzaki, A Kato, S Terai, K Okita

    GASTROENTEROLOGY   112 ( 4 )   A1309 - A1309   1997.4

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  • Inhibition of tumor necrosis factor-alpha prevent sliver regeneration after partial hepatectomy.

    T Kimura, Sakaida, I, S Terai, K Uchida, Y Matumura, K Kayano, K Okita

    GASTROENTEROLOGY   112 ( 4 )   A1303 - A1303   1997.4

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  • JNK(SAPK)/MEKK signal induced the enhancement of transcriptional activation of p53

    S Terai, K Uchida, T Kimura, Sakaida, I, K Okita, T Noma

    MOLECULAR BIOLOGY OF THE CELL   7   2058 - 2058   1996.12

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  • Inhibition of tumor necrosis factor-alpha prevents liver regeneration after partial hepatectomy.

    T Kimura, Sakaida, I, S Terai, K Uchida, Y Matsumura, K Okita

    HEPATOLOGY   24 ( 4 )   1625 - 1625   1996.10

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  • MEKK・JNKカスケードによる癌抑制遺伝子p53の転写活性の増加

    寺井 崇二, 内田 耕一, 木村 輝昭, 坂井田 功, 沖田 極, 野間 隆文

    日本分子生物学会年会プログラム・講演要旨集   19   702 - 702   1996.8

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  • キノン体E3330のTNF-α産生阻害による肝再生の抑制

    木村 輝昭, 寺井 崇二, 内田 耕一, 松村 康博, 坂井 田功, 沖田 極, 野間 隆文

    日本分子生物学会年会プログラム・講演要旨集   19   162 - 162   1996.8

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  • A case of hepatocellular carcinoma (HCC) with long term survival by transcatheter arterial embolization (TAE) and percutaneous ethanol injection therapy (PEIT) to tumor thrombus in the right portal vein (Vp3)

    Yamasaki, T., Nishikawa, J., Irie, K., Matsuzaki, Y., Terai, S., Yamashita, A., Kurokawa, F., Yasunaga, M., Okita, K., Kimura, T., Okuda, M., Mizumachi, S.

    Kanzo   35 ( 6 )   448 - 454   1994.6

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Industrial property rights

  • 臓器線維症の診断を補助する方法、被験者における臓器での強固な線維の構築しやすさを予測する方法、及び、臓器線維症の診断用試薬

    土屋 淳紀, 寺井 崇二, 植田幸嗣

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  • 臓器線維症の診断を補助する方法、被験者における臓器での強固な線維の構築しやすさを予測する方法、及び、臓器線維症の診断用試薬

    土屋 淳紀, 寺井 崇二, 植田 幸嗣

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    Application no:特願2023-014537  Date applied:2023.2

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  • 脂肪肝および非アルコール性脂肪肝炎の治療薬

    寺井 崇二, 土屋 淳紀, 玉井 克人, 新保 敬史, 山﨑 尊人

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  • 情報処理装置と情報処理プログラムと情報処理方法

    浜本 義彦, 荻原 宏是, 寺井 崇二, 横山 純二, 佐藤 裕樹

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    Application no:特願2021-088015  Date applied:2021.5

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  • 情報処理装置と情報処理プログラムと情報処理方法

    浜本 義彦, 荻原 宏是, 寺井 崇二, 横山 純二, 佐藤 裕樹

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    Application no:特願2021-088015  Date applied:2021.5

    Announcement no:特開2022-181140  Date announced:2022.12

    Patent/Registration no:特許第7599171号  Date registered:2024.12 

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  • 血中アンモニア濃度を低下させる剤

    門田 吉弘, 栃尾 巧, 寺井 崇二, 土屋 淳紀, 吉田 智彰, 高橋 志達, 岡 健太郎

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    Application no:特願2020-185985  Date applied:2020.11

    Announcement no:特開2022-075294  Date announced:2022.5

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  • 血中アンモニア濃度を低下させる剤

    寺井 崇二

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  • 筋肉量率の増加剤、水分量率の増加剤および体脂肪率の減少剤

    寺井 崇二

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  • 筋肉量率の増加剤、水分量率の増加剤および体脂肪率の減少剤

    門田 吉弘, 栃尾 巧, 寺井 崇二, 土屋 淳紀, 冨永 顕太郎, 高橋 志達, 岡 健太郎, 峯村 采花

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    Application no:特願2020-120744  Date applied:2020.7

    Announcement no:特開2022-017906  Date announced:2022.1

    Patent/Registration no:特許7688866  Date registered:2025.5 

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  • 膵臓癌モデル非ヒト動物及びその使用

    上村 顕也, 寺井 崇二

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  • 膵臓癌モデル非ヒト動物及びその使用

    上村 顕也, 寺井 崇二, 柴田 理, 五十嵐 聡

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    Applicant:国立大学法人 新潟大学

    Application no:特願2020-102959  Date applied:2020.6

    Announcement no:特開2021-193943  Date announced:2021.12

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  • 膵臓癌モデル非ヒト動物及びその使用

    上村 顕也, 寺井 崇二, 柴田 理, 五十嵐 聡

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    Application no:特願2020-102959  Date applied:2020.6

    Announcement no:特開2021-193943  Date announced:2021.12

    Patent/Registration no:特許第7533928号  Date registered:2024.8 

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  • マクロファージの誘導方法、抗炎症性マクロファージの誘導剤及び医薬組成物

    寺井 崇二, 土屋 淳紀, 竹内 卓

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    Application no:JP2020009639  Date applied:2020.3

    Patent/Registration no:特許第7513284号  Date registered:2024.7 

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  • 線維化誘導遺伝子の発現抑制剤およびその用途

    榎本 初音, 立木 秀尚, 中嶋 幹郎, 大山 要, 曽木 洋志, 宮元 敬天, 稲嶺 達夫, 寺井 崇二, 上村 顕也, 酒井 規裕

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    Application no:JP2019042747  Date applied:2019.10

    Publication no:WO2020-090967  Date published:2020.5

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  • マクロファージの誘導方法、抗炎症性マクロファージの誘導剤及び医薬組成物

    寺井 崇二, 土屋 淳紀

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  • 線維化誘導遺伝子の発現抑制剤およびその用途

    寺井 崇二, 上村 顕也

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  • ⼿⾜症候群の予防または改善⽤組成物

    寺井 崇二, 上村 顕也

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  • 手足症候群の予防または改善用組成物

    上村 顕也, 寺井 崇二, 野沢 与志津, 小山 直人

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    Application no:JP2018034710  Date applied:2018.9

    Publication no:WO2019-059246  Date published:2019.3

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  • 手足症候群の予防または改善用組成物

    上村 顕也, 寺井 崇二, 野沢 与志津, 小山 直人

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    Application no:JP2018034710  Date applied:2018.9

    Patent/Registration no:特許第7103363号  Date registered:2022.7 

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  • 内視鏡用アタッチメントフード

    寺井 崇二, 水野 研一

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  • 内視鏡用アタッチメントフード

    池田 英昭, 佐藤 良, 水野 研一, 寺井 崇二

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    Application no:特願2018-144085  Date applied:2018.7

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  • 内視鏡用アタッチメントフード

    池田 英昭, 佐藤 良, 水野 研一, 寺井 崇二

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    Application no:特願2018-144085  Date applied:2018.7

    Announcement no:特開2020-018524  Date announced:2020.2

    Patent/Registration no:特許第7181545号  Date registered:2022.11 

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  • 肝線維化疾患の予防⼜は治療剤

    寺井 崇二

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    Application no:特願特願2017-182148  Date applied:2017.9

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  • 肝線維化疾患の予防又は治療剤

    寺井 崇二, 土屋 淳紀, 小島 雄一, 山下 潤二, 原 幸生, 中島 謙治

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    Applicant:国立大学法人 新潟大学

    Application no:特願2017-182148  Date applied:2017.9

    Announcement no:特開2021-008402  Date announced:2021.1

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  • 膵臓癌治療システム

    寺井 崇二

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  • 膵臓癌治療システム

    上村 顕也, 寺井 崇二

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    Applicant:国立大学法人 新潟大学

    Application no:特願2017-172377  Date applied:2017.9

    Announcement no:特開2019-047844  Date announced:2019.3

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  • 膵臓癌治療システム

    上村 顕也, 寺井 崇二

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    Applicant:国立大学法人 新潟大学

    Application no:特願2017-172377  Date applied:2017.9

    Announcement no:特開2019-047844  Date announced:2019.3

    Patent/Registration no:特許第6943427号  Date registered:2021.9 

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  • 肝がんの治療剤

    上村 顕也, 寺井 崇二

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    Applicant:国立大学法人 新潟大学

    Application no:特願2017-080417  Date applied:2017.4

    Announcement no:特開2018-177705  Date announced:2018.11

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  • 臓器、組織又は器官モデル

    ▲くわ▼原 豊, 小川 敦, 水野 研一, 佐藤 裕樹, 寺井 崇二

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    Applicant:サンアロー株式会社, 国立大学法人 新潟大学

    Application no:特願2015-241410  Date applied:2015.12

    Announcement no:特開2017-107094  Date announced:2017.6

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  • 臓器、組織又は器官モデル

    ▲くわ▼原 豊, 小川 敦, 水野 研一, 佐藤 裕樹, 寺井 崇二

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    Applicant:サンアロー株式会社, 国立大学法人 新潟大学

    Application no:特願2015-241410  Date applied:2015.12

    Patent/Registration no:特許第6055069号  Date registered:2016.12  Date issued:2016.12

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  • 間葉系幹細胞の培養方法、および肝機能障害用治療剤の製造方法

    坂井田 功, 寺井 崇二, 高見 太郎, 藤澤 浩一, 山本 直樹, 米田 健二

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    Applicant:国立大学法人山口大学

    Application no:特願2014-189378  Date applied:2014.9

    Announcement no:特開2016-059322  Date announced:2016.4

    Patent/Registration no:特許第6519727号  Date registered:2019.5 

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  • 間葉系幹細胞の活性評価方法、間葉系幹細胞の培養方法、肝機能障害用治療剤の製造方法、および肝機能障害用治療剤

    坂井田 功, 寺井 崇二, 高見 太郎, 藤澤 浩一, 山本 直樹, 米田 健二

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    Applicant:国立大学法人山口大学, 澁谷工業株式会社

    Application no:特願2014-189378  Date applied:2014.9

    Announcement no:特開2016-059322  Date announced:2016.4

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  • 画像処理装置、画像処理方法、画像処理プログラム

    浜本 義彦, 藤田 悠介, 橋本 真一, 寺井 崇二, 坂井田 功

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    Applicant:国立大学法人山口大学

    Application no:特願2012-193185  Date applied:2012.9

    Announcement no:特開2014-046085  Date announced:2014.3

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  • 画像処理装置、画像処理方法、画像処理プログラム

    浜本 義彦, 藤田 悠介, 橋本 真一, 寺井 崇二, 坂井田 功

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    Applicant:国立大学法人山口大学

    Application no:特願2012-193185  Date applied:2012.9

    Patent/Registration no:特許第5164127号  Date registered:2012.12  Date issued:2012.12

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  • NAFLDの進展度合いを判定する方法

    寺井 崇二, 大石 俊之, 坂井田 功, 桑代 紳哉, 宮島 篤

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    Applicant:国立大学法人山口大学

    Application no:特願2010-128364  Date applied:2010.6

    Announcement no:特開2011-252868  Date announced:2011.12

    Patent/Registration no:特許第5574331号  Date registered:2014.7  Date issued:2014.7

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  • NAFLDの進展度合いを判定する方法

    寺井 崇二, 大石 俊之, 坂井田 功, 桑代 紳哉, 宮島 篤

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    Applicant:国立大学法人山口大学, 国立大学法人 東京大学

    Application no:特願2010-128364  Date applied:2010.6

    Announcement no:特開2011-252868  Date announced:2011.12

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  • ナトリウム利尿ペプチドを有効成分とする肝硬変・前癌病変の抑制剤

    坂井田 功, 寺井 崇二, 山本 直樹

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    Applicant:国立大学法人山口大学, アスビオファーマ株式会社, 第一三共株式会社

    Application no:特願2007-114293  Date applied:2007.4

    Announcement no:特開2010-168283  Date announced:2010.8

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  • 肝再生用骨髄細胞画分

    坂井田 功, 寺井 崇二

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    Applicant:国立大学法人山口大学

    Application no:特願2005-286546  Date applied:2005.9

    Announcement no:特開2007-089532  Date announced:2007.4

    Patent/Registration no:特許第4752058号  Date registered:2011.6  Date issued:2011.6

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  • 肝再生用骨髄細胞画分

    坂井田 功, 寺井 崇二

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    Applicant:国立大学法人山口大学

    Application no:特願2005-286546  Date applied:2005.9

    Announcement no:特開2007-089532  Date announced:2007.4

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  • 生体液中のイオン濃度測定装置

    寺井 崇二, 三浦 泉, 坂井田 功, 沖田 極

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    Applicant:国立大学法人山口大学

    Application no:特願2005-079248  Date applied:2005.3

    Announcement no:特開2006-255268  Date announced:2006.9

    Patent/Registration no:特許第4710005号  Date registered:2011.4  Date issued:2011.4

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  • 生体液中のイオン濃度の測定方法

    寺井 崇二, 三浦 泉, 坂井田 功, 沖田 極

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    Applicant:国立大学法人山口大学

    Application no:特願2005-079248  Date applied:2005.3

    Announcement no:特開2006-255268  Date announced:2006.9

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  • 肝細胞癌の新規腫瘍マーカーとしての機能を有する抗HHMIgG抗体、肝癌のスクリーニング法および肝癌進行度のマーカーとしての利用

    寺井 崇二, 高見 太郎, 坂井田 功, 沖田 極

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    Applicant:国立大学法人山口大学

    Application no:特願2004-267065  Date applied:2004.9

    Announcement no:特開2006-084224  Date announced:2006.3

    Patent/Registration no:特許第4465467号  Date registered:2010.3  Date issued:2010.3

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  • 肝細胞癌の新規腫瘍マーカーとしての機能を有する抗HHMIgG抗体、肝癌のスクリーニング法および肝癌進行度のマーカーとしての利用

    寺井 崇二, 高見 太郎, 坂井田 功, 沖田 極

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    Applicant:国立大学法人山口大学

    Application no:特願2004-267065  Date applied:2004.9

    Announcement no:特開2006-084224  Date announced:2006.3

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  • 骨髄細胞の遊走・分化・増殖評価モデル動物およびその利用法

    寺井 崇二, 沖田 極

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    Applicant:国立大学法人山口大学

    Application no:特願2001-271240  Date applied:2001.9

    Announcement no:特開2003-070377  Date announced:2003.3

    Patent/Registration no:特許第4997377号  Date registered:2012.5  Date issued:2012.5

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  • 骨髄細胞の遊走・分化・増殖評価モデル動物およびその利用法

    寺井 崇二, 沖田 極

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    Applicant:有限会社 山口ティー・エル・オー

    Application no:特願2001-271240  Date applied:2001.9

    Announcement no:特開2003-070377  Date announced:2003.3

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  • 肝がんの治療剤

    寺井 崇二

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Awards

  • The Japanese Society for Regenerative Medicine Award

    2022.3   The Japanese Society for Regenerative Medicine   Development of regenerative therapy for liver cirrhosis

    SHUJI TERAI

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  • President award

    2021.8   Niigata University  

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  • President award

    2020.8   Niigata University  

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  • 胃と腸 賞

    2018  

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  • 平成23年度 山口大学功績賞(ベストテイーチャー部門)

    2012.2  

    寺井 崇二

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  • 2011 Liver meeting :Distinction poster of presidential

    2011  

    Shuji Terai

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  • 平成22年度 オンライン学生評価最優秀賞(ベストテイーチャー)

    2010  

    寺井 崇二

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  • 平成19年度 第37回 霜仁会賞(山口大学医学部同窓会)学術奨励賞本賞

    2008.5  

    寺井 崇二

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  • 平成17年度日本肝臓学会 Otsuka Award

    2005.10  

    寺井 崇二

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  • Award of Excellence for outstanding participation and discussion at Educational Seminar for Young Investigator The 2nd Japan GRG/AGA symposium

    2003.12  

    Shuji Terai

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  • 第24回日本炎症・再生医学会 優秀演題

    2003.11  

    寺井 崇二

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  • 平成13年度(財)宇部興産学術振興財団渡辺記念特別奨励賞

    2002.5  

    寺井 崇二

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  • 第1回再生医療学会 優秀演題

    2002.4  

    寺井 崇二

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  • 平成13年度山口大学ニューフロンテイアプロジェクト

    2001  

    寺井 崇二

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  • 平成13年度国際科学振興財団研究助成

    2001  

    寺井 崇二

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  • 平成10年度日本消化器病学会奨励賞

    1998.10  

    寺井 崇二

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  • 厚生省新がん克服十カ年戦略、日本がん研究振興財団海外派遣研究員(fellow ship) (プロジェクトリーダー、国立ガンセンター総長、寺田雅昭)

    1998.7  

    寺井 崇二

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Research Projects

  • 肝細胞への選択的取り込みが可能な間葉系幹細胞由来細胞外小胞の開発

    Grant number:24K11126

    2024.4 - 2027.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    阿部 寛幸, 寺井 崇二, 上村 顕也, 渡邉 雄介

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy

    Grant number:23K27454

    2023.4 - 2027.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\18330000 ( Direct Cost: \14100000 、 Indirect Cost:\4230000 )

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  • Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy

    Grant number:23H02763

    2023.4 - 2027.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\18330000 ( Direct Cost: \14100000 、 Indirect Cost:\4230000 )

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  • Extracellular Vesicles Regulate Progressive Congestive Hepatopathy due to Heart Failure

    Grant number:23K07372

    2023.4 - 2026.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • Identification of malignant extracellular vesicles of liver origin that regulate nonalcoholic steatohepatitis and the development of the treatment

    Grant number:22H03055

    2022.4 - 2025.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

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  • Elucidation of the Mechanism of Regenerative Insufficiency in Advanced Liver Cirrhosis Caused by Intestinal Bacterial Extracellular Vesicles and Development of Prevention and Treatment Methods

    Grant number:22H02866

    2022.4 - 2025.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\16250000 ( Direct Cost: \12500000 、 Indirect Cost:\3750000 )

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  • Development of novel treatment for non-alcoholic steatohepatitis by the research for the mechanism of regulation of liver fat accumulation

    Grant number:22K08006

    2022.4 - 2025.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

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  • 非アルコール性脂肪肝炎の病態を制御する肝臓由来の悪玉細胞外小胞の同定と治療法開発

    Grant number:22551408

    2022.4 - 2025.3

    System name:科学研究費助成事業 基盤研究(B)

    Awarding organization:文部科学省

    寺井崇二, 土屋淳紀

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  • Elucidation of the Mechanism of Regenerative Insufficiency in Advanced Liver Cirrhosis Caused by Intestinal Bacterial Extracellular Vesicles and Development of Prevention and Treatment Methods

    Grant number:23K24128

    2022.4 - 2025.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\16250000 ( Direct Cost: \12500000 、 Indirect Cost:\3750000 )

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  • Identification of malignant extracellular vesicles of liver origin that regulate nonalcoholic steatohepatitis and the development of the treatment

    Grant number:23K24316

    2022.4 - 2025.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

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  • Application of the Autonomic Nervous Management for NAFLD Treatment

    Grant number:21K19478

    2021.7 - 2024.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

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  • Analysis of oral-derived pathobiont associated with colorectal cancer

    Grant number:21K19592

    2021.7 - 2023.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

    Tabeta Koichi

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    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

    Previous oral-gut association studies have suggested an association between periodontopathogenic bacteria and colorectal cancer. We performed microbiome analysis of clinical specimens from polyp patients for exploring oral-derived pathogenic pathobiont. Our results did not reveal any bacteria characteristic of colorectal cancer, but suggested that many oral bacteria are present in the intestinal tract and may affect the bacterial flora of the intestinal mucosal surface.

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  • 遺伝子導入によるラット胆管癌モデルの確立と浸潤能評価による病態マーカー開発

    Grant number:21K07889

    2021.4 - 2024.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    五十嵐 聡, 寺井 崇二, 上村 顕也, 横尾 健

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    ハイドロダイナミック遺伝子導入法(HGD)によるラット胆管特異的な遺伝子導入のための注入パラメータを確立する。

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  • Pancreatic cancer biomarker research by the exosome proteome analysis of the HGD rat pancreatic cancer model

    Grant number:21K07910

    2021.4 - 2024.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • Development of Hydrodynamics-based Gene Therapy for the Pancreatic Cancer

    Grant number:20K08379

    2020.4 - 2024.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Kamimura Kenya

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    In this project, in order to develop a novel therapeutic method for the pancreatic cancer, we applied pancreas-targeted HGD to establish a pancreatic cancer model, HGD parameters, and therapeutic target genes. Firstly, we performed HGD using various pancreatic cancer-related genes which are reported to be activated in human pancreatic cancer. We observed tumor formation in rat pancreas and found the tumor development efficiently in a short period of time. The histopathological analyses have shown the multistage pancreatic cancer model ranging from pancreatic ductal epithelial atypia to high-grade pancreatic cancer, and distant organ metastasis. Using this model, we analyzed parameters for pancreatic cancer gene therapy and gene and protein expression changes in tissues and serum to select therapeutic genes can be used for the gene therapy.
    The above results revealed that pancreas-selective HGD can be applied as a useful methodology for pancreatic cancer treatment.

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  • Elucidation of Extracellular Vesicles Contributing Liver and Muscle Linkage

    Grant number:20K08326

    2020.4 - 2023.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Kamimura Hiroteru

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    We searched for markers of early detection associated with sarcopenia in a mouse model of liver cirrhosis. Since it had been reported that spontaneous locomotion using a rotating cage suppressed hepatic carcinogenesis, we measured changes in liver tissue, fibrosis markers, muscle strength, muscle tissue, myokine, and extracellular vesicles over a short period of time using a rotating cage spontaneous locomotion measuring device in a cirrhotic mouse model. For myokine, multiplex assay analysis was performed on serum and direct muscle to identify key factors in the inter-organ system that contribute to the improvement of liver function by rehabilitation. We aim to identify key factors involved in the organ systems that contribute to the improvement of liver function by exercise rehabilitation.

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  • 診断困難な消化管運動異常症と機能性消化管疾患との境界症例の病態解明

    Grant number:20K08279

    2020.4 - 2023.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    佐藤 裕樹, 寺井 崇二, 上村 顕也, 浜本 義彦

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    シネMRIによる小腸運動能の解析を継続して行った。Mahalanobis距離を解析に組み合わせることで消化管運動能の評価を画像解像度の影響を受けず客観的行うことができた(特許出願中)。慢性偽性腸閉塞症(CIPO)においては腸管蠕動能の低下・腸管径の拡大から過敏性腸症候群(Irritable bowel syndrome: IBS)・健常者(Healthy control:HC)との鑑別は比較的容易であり診断のためのカットオフ値を設定することができた。一方、IBSにおいてはその腸管運動能は多岐にわたり、HCとのオーバーラップも多く認めたことから、運動能の評価には更なる工夫が必要と考えられた(論文投稿中、major revision)。我々の研究ではHCや非CIPO患者においては小腸運動能は個体差も大きいと考えられ(Tominaga, et al. Ann Transl Med. 2020)、これがオーバーラップの一因であると示唆される。小腸運動には蠕動運動・分節運動・振子運動があり内容物種類によりこれらが様々な割合で出現するがCIPO患者ではこれらすべてが低下していると考えられる。一方で、健常者・非CIPO患者においてはそれぞれ種類の運動能の評価が必要と考えられ、そのためには長時間の運動パターンの観察・解析する必要があり更なる研究が必要である。
    また、食道アカラシアなどの食道運動異常症においては食道憩室の合併を認めることがあるが、その頻度は約3.2%であった。これら疾患においては下部食道括約筋の弛緩不全が食道憩室発生の原因であったため内視鏡的筋層切開術(POEM)が有効であった。また、食道憩室における食道運動異常症の合併頻度は66.6%であり、食道憩室の多くは食道運動異常症によることが確認できた。

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  • 抗線維化・再生誘導剤の開発:臨床を見据えた肝硬変に対する間葉系幹細胞由来のエクソソームを用いた次世代治療法開発への基盤研究

    Grant number:20314294

    2020.4 - 2023.3

    System name:肝炎等克服実用化研究事業

    Awarding organization:国立研究開発法人日本医療研究開発機構

    寺井崇二, 土屋淳紀

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  • Approaching the darkness of oral Helicobacter pylori: exploratory research on isolation / identification, infection mechanism, and persistent infection regulators

    Grant number:19K22704

    2019.6 - 2021.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

    Noiri Yuichiro

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    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

    The detection rate of Helicobacter pylori in the oral cavity is not clear.In this study,we attempted to detect H.pylori from oral biofilms using the Nested PCR methods.In this study,using a Nested PCR method was tried to detect H.pylori from oral biofilms.The Nested PCR method used in this study was able to detect H.pylori with high sensitivity. Subsequently,by Nested PCR method, from the gastric H.pylori suffering patient's gastric tissue,H.pylori DNA was detectable 100%.If H.pylori was alive in the oral cavity,the oral cavity could function as a persistent gastric infectious reservoir.Confirmation of the homology could not be carried out within the study period. Oral H.pylori DNA was frequently detected in patients with a history of gastric H.pylori infection.Oral H. pylori has characteristic distribution independent of sex and age,suggesting that it is part of the normal microflora in the oral cavity.

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  • Elucidation of regulatory function of the basal lamina fenestrations in intestinal villous epithelium for fat absorption.

    Grant number:19K08462

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Yokoyama Junji

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    We observed the white change of duodenal villi seen in the obese person with an optical microscope. Lymphatic dilatation was not seen, and the white change seemed to reflect the chylomicron accumulated in the cell and the intercellular gap. From this, it was suggested that the fenestrations seen in the basement membrane of the small intestinal villi adjusted the transportation of the chylomicron to the central lacteal, and that the passage of the chylomicron might be severely restricted in the obese person. That is, it was presumed that the fenestration of the basement membrane was working in the direction which contributed to the suppression of hyperlipidemia and obesity. In addition, it was considered that the correlation between the efficiency of fat absorption and the basement membrane fenestration should be comprehensively examined, including the leaky gut syndrome and the relationship with small intestinal bacterial overgrowth.

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  • Development of a treatment to improve fibrosis and elucidation of carcinogenesis mechanisms in improved NASH model MC4RKO mice

    Grant number:19H03636

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Terai Shuji

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    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    Using MC4R-KO mice, a mouse model of NASH, we first examined the effects on fibrosis and tumors to establish an early fibrosis model and an early tumorigenesis model. Using the early fibrosis model, we found that mesenchymal stem cells and their exosomes ameliorate inflammation and fibrosis. Furthermore, in the tumorigenesis model, we established an early tumorigenesis model by blocking S1P-S1PR2 signaling in MC4R-KO mice fed a high-fat diet with the drug JTE-013, and found that the mice showed a high rate of hepatocellular carcinoma at early stage.

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  • The study of emergence of cancerous gland in chronic gastritis through three dimensional histological structure and genetic analysis

    Grant number:19K08389

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Yagi Kazuyoshi

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    According to our investigation, the following was realized: in chronic gastritis, chief cell changed to MUC6 cell which formed pyloric gland metaplasia and furthermore changed to intestinal metaplasia in expressing of CDX2.On the other hand, cancerous cells occurred from MUC6 cells, especially in CDX2-positive cell. We supposed that cancerous cells developed from MUC6 cells by trigger of expression of CDX2.We analyzed genes of cancerous tissue, pyloric gland metaplasia and intestinal metaplasia in three cases of gastric cancer. In two of three cases, the pyloric gland metaplasia and cancer had a close relationship, whereas the intestinal metaplasia and cancer were distantly related. We thought that in these two cancers, the pyloric gland metaplasia and cancer were closely related genetically, and the intestinal metaplasia and cancer were distantly related, suggesting that these cancers did not follow the metaplasia-dysplasia-cancer sequence.

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  • Efficacy of mesenchymal stem cell for prevention of esophageal stricture after endoscopic submucosal dissection

    Grant number:19K08390

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hashimoto Satoru

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Esophageal stricture following endoscopic treatment for esophageal cancer is caused by fibrosis in the submucosal layer during the mucosal healing process. In this study, we created a rat skin fistula model and investigated the effects of mesenchymal stem cells (MSCs), which are known to have anti-inflammatory and anti-fibrotic properties, by injecting them. In the MSC local injection group, we observed accumulation of macrophages coinciding with the administration site, and a significant presence of CD31-positive cells suggesting neovascularization in the vicinity. Conversely, these reactions were not observed in the MSC non-local injection group, leading us to speculate that local injection of MSCs induces the initiation of tissue healing.

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  • Mechanisms of extrahepatic complications in NAFLD/NASH with focus on exosomes

    Grant number:19K08417

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Takamura Masaaki

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    In this study, we observed the dynamics of exosomes in human CD63-GFP Tg rats, which can visualize exosomes, and conducted a proteome analysis of exosome-incorporated proteins in the blood of rats fed a high-fat diet and control rats to search for candidate proteins involved in the pathogenesis of extrahepatic complications. We searched for candidate proteins involved in the pathogenesis of extrahepatic complications.
    Exosomes were identified in the stomach and kidney, but their expression in the liver was insufficient for further validation. No protein was identified that was expressed in both groups with a 2-fold or greater difference in expression. Many of the proteins identified in high-fat diet-fed NAFLD rats alone have not been reported in NAFLD and require further investigation in the context of clinical data.

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  • Effect of Organ Communication on Liver Function upon the Liver Injury

    Grant number:18K19537

    2018.6 - 2020.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

    Shuji Terai

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    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    The development of therapeutic options to promote hepatic is essential. While humoral factors have been reported as mechanisms of liver regeneration, the contributions of inter-organ communication to liver regeneration have not been reported. Therefore, in this study, we examined the effect of neural relay on liver regeneration via activation of gastrointestinal hormone release from the gastrointestinal tract. Our results demonstrated that the afferent visceral nerve from the liver activates the efferent vagus nerve from the brain, leading to activation of hormone release from the gastrointestinal tract and contributing to the liver regeneration.

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  • Development of novel anti-inflammatory therapy using mesenchymal stem cells

    Grant number:18K07903

    2018.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Tsuchiya Atsunori

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    We tried to develop mouse acute liver injury model using anti-Fas antibody, carbon tetrachloride (CCl4), CCl4 + lipopolysaccharide, acetaminophen and D-Galactosamine, and found that CCl4 induced acute liver injury model was most stable model for our analysis. Using this model, we tried to inject mesenchymal stem cells (MSCs) or their exosomes by three different ways around the time of acute liver damage; 1) pre-injection, 2) simultaneous injection, 3) post-injection. Our analysis showed that pre-injection of MSCs was most effective for acute liver injury. However, in clinical setting, pre-treatment of MSCs is very difficult, thus we concluded that MSC therapy is more appropriate for chronic liver injury model than acute liver injury model.

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  • 消化器発癌における免疫老化による免疫監視不全の関与の解明と新規先制医療の開発

    Grant number:18K07965

    2018.4 - 2021.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    山際 訓, 寺井 崇二, 高村 昌昭, 松田 康伸

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • The Prevention of Fibrosis by the Elucidation of Interaction between Lymphoid Follicles and Activated Liver Stellate Cell.

    Grant number:17H06691

    2017.8 - 2019.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

    Research category:Grant-in-Aid for Research Activity Start-up

    Awarding organization:Japan Society for the Promotion of Science

    Kamimura Hiroteru, Setsu Toru, Kamimura Kenya, Takamura Masaaki, Terai Shuji

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    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

    Reactive lymphoid follicle in the liver has been detected in the patients chronic hepatitis C(CH-C),primary biliary cholingitis and autoimmune hepatitis.
    The hepatic mass lesion characterized by a dense circumscribed, expansively growing lymphocyte infiltrate with lymph follicles and sometimes germinal centers. Using immunohistological methods, we studied the lymphoid follicles in liver biopsy specimens obtained from the CH-C patients before interferon and DAA therapy. We analyzed various immunocompetent cells in the surrounding interface area that appeared to be differentiated in tissues with lymphoid follicles. Mainly we detected an interesting finding about the relationship with hepatic stellate cells.

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  • The pathological role of secreted protein in promoting fibrosis in non alcoholic steatohepatitis.

    Grant number:17K19648

    2017.6 - 2019.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

    Shimizu Ippei, Minamino Tohru, Yoshida Yohko, Okuda Shujiro, Sakimura Kenji, Terai Shuji, Sasaoka Toshikuni, Nakagami Hironori

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    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

    Non-alcoholic fatty liver disease (NAFLD) develops with obesity. Non-alcoholic steatohepatitis (NASH) is the extreme form of NAFLD characterized with sterile inflammation and fibrosis in the liver. NASH patients are increasing in many societies, however, the molecular mechanisms of fibrosis in the liver are largely unknown. We found a significant increase in obesity associated pro-fibrotic protein (OAFP) level in the serum from NASH patients compared to control groups. Obese-NASH model developed significant liver fibrosis associated with high circulating OAFP level. Injection of a plasmid encoding OAFP into skeletal muscle promoted fibrosis in the liver. In contrast, genetic suppression of OAFP inhibited liver fibrosis. Our studies from humans and rodents suggest the pathological role of OAFP in promoting fibrotic responses in liver upon metabolic stress. Suppression of OAFP would become next generation therapy for NASH.

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  • 肝臓特異的ハイドロダイナミック法による核酸医薬送達と肝癌遺伝子治療法への応用

    Grant number:17K09408

    2017.4 - 2021.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    上村 顕也, 寺井 崇二, 坂牧 僚, 横尾 健

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    本研究は、ハイドロダイナミック遺伝子導入法(HGD)を肝癌治療に応用するための方法論、抗腫瘍効果を学術的に検証するためのステップと位置づけ、HGDパラメーターの確立、治療遺伝子の選択、効果と安全性の検証、肝癌モデル動物に対する治療効果の検証を行うことを目的とした。
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    今年度は前二年度に肝癌の増殖制御に有用であることを明らかにした、ジフテリアトキシンA遺伝子を用いた肝癌に対する遺伝子治療確立のためのマウス肝癌モデルに対する遺伝子治療効果を検証した。
    これまでに、in vitroでは、ジフテリアトキシンA発現遺伝子が肝細胞癌に対して抗腫瘍効果を有することを明らかにし、同遺伝子を肝癌で発現するAFPのプロモーター制御下に発現するコンストラクトを作成した。今年度は、発がん遺伝子をハイドロダイナミック遺伝子導入法でマウス肝に遺伝子導入して作製したマウス肝癌モデルに対する、ジフテリアトキシン遺伝子Aの遺伝子治療効果を検討した。また、プロモーター選択性による遺伝子治療の安全性も検証した。
    具体的には、肝癌マウスモデルに対して、腫瘍発生の各段階において、ジフテリアトキシンA遺伝子発現コンストラクトによる遺伝子治療を行い、腫瘍数、腫瘍径、腫瘍マーカー、などにより治療効果を、血液生化学的評価による安全性の検討を行った。
    その結果、肝癌モデルマウスにおいても肝発癌率の抑制、腫瘍マーカーの低下を認め、ジフテリアトキシンA遺伝子による肝癌遺伝子治療の効果を実証することができた。またプロモーター選択性により、肝障害の観点からも安全な遺伝子治療が可能であった。本研究の成果により、プロモータ選択性によりジフテリアトキシンA遺伝子を用いた種々の悪性疾患治療が可能であることが示唆された。

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  • Mechnism for improvemnt of pathophysiological condition in NASH treated with 7,8-Dihydroxyflavone

    Grant number:17K09409

    2017.4 - 2020.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Kawai Hirokazu

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    We initially investigated the therapeutic efficacy of 7,8-dihydroxyflavone (7,8-DHF) on non-alcoholic steatohepatitis (NASH) using the melanocortin 4 receptor-knocked out (MC4R-KO) mouse, however the beneficial effect of 7,8-DHF was not found. Then, we conducted the adjusted plan to reveal the effect of alcohol intake on NASH using the MC4R-KO mouse which were fed high-fat diet and alcohol. The ingestion of alcohol significantly increased liver/epididymal fat weight ratio, fat area in the liver histology, and mRNA expression of an ER stress marker, an inflammatory marker, and lipid metabolism-related genes. In conclusion, this study demonstrated that alcohol intake in NASH augmented fat deposition, ER stress, and inflammation in the liver.

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  • Establishment of the 3D minute blood vessel diagnostic method to esophageal cancer by the digital substance microscope fluorescence imaging

    Grant number:16K09405

    2016.4 - 2020.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Takeuchi Manabu

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    Predicting invasion depth of superficial esophageal squamous cell carcinoma is crucial in determining the precise indication for endoscopic resection because the rate of lymph node metastasis increases in proportion to the invasion depth of the carcinoma. The Japan Esophageal Society (JES) developed a simplified magnifying endoscopic classification for estimating invasion depth of superficial esophageal squamous cell carcinomas. We conducted a prospective study to evaluate the diagnostic values of type B vessels in the pretreatment estimation of invasion depth of superficial esophageal squamous cell carcinomas utilizing JES classification.We enrolled 211 patients with superficial esophageal squamous cell carcinoma. The overall accuracy of type B microvessels in estimating tumor invasion depth was 90.5 %. We propose that the newly developed JES magnifying endoscopic classification is useful in estimating the invasion depth of superficial esophageal squamous cell carcinoma.

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  • Development of gene therapy for liver cirrhosis utilizing MMP13

    Grant number:16K19333

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category:Grant-in-Aid for Young Scientists (B)

    Awarding organization:Japan Society for the Promotion of Science

    Yokoo Takeshi, OGAWA kohei, KOBAYASHI yoko, KAMIMURA kenya, OBA yoshihiko, YOSHINO hideyoshi, OTSUKA masato, ODA masafumi, Liu Dexi, TERAI shuji

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    MMP13 is one of enzyme, which has the possibility of ameliorating liver fibrosis. We evaluated whether gene therapy using MMP13 could resolve liver cirrhosis of rat. Hydrodynamic gene delivery of MMP13 to the cirrhotic liver showed to suppress progression of liver fibrosis in the rats with continuous stimulation to cause liver inflammation and fibrosis. In addition, the delivery also demonstrated to decrease fibrotic tissue in the rats without the stimulation.

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  • Efficacy of gelatin hydrogels incorporating triamcinolone acetonide for prevention of esohageal fibrosis after endoscopic submucosal dissection

    Grant number:16K09280

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Satoru Hashimoto, TABATA yasuhiko

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Triamcinolone acetonide (TA), a steroid, is often used clinically to prevent dysfunctions associated with fibrosis. TA was suspended in biodegradable gelatin and freeze-dried in a sheet form. In this study, we prepared a TA suspension gelatin sheet (TA sheet) and confirmed both the homogeneity of suspended TA and controlled-release of TA in the presence of collagenase in vitro. The TA sheet decreased the rate of skin wound regeneration and caused less myofibroblast infiltration into the tissue than the control sheet did. In addition, the TA sheet caused less myofibroblast infiltration into the tissue than TA injection.

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  • Analysis of the basal lamina fenestrations in intestinal villous epithelium and the relation to the regulation of nutrient absorption

    Grant number:16K09303

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    YOKOYAMA Junji, YAGI Kazuhiro, AZUMI Rie, MORITA Keisuke

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    We investigated the ultrastructure of the intestinal villi in the rat by scanning electron microscopy. Our study showed that free cells adhering to the fenestrations increased in the upper jejunum two hours after feeding high-fat diet and the size of the fenestrations in this region also increased after feeding high-fat diet for 2 days. This enlargement of fenestrations may play an important role in increasing the efficiency of lipid absorption by facilitating the movement of chylomicrons from the intercellular space to the lamina propria. Similar changes were also observed in the study of human small intestine villi. In addition, we observed jejunal white spots of lymphangiectasia by magnified balloon enteroscopy. We are planning to further examine the relationship between white villi, which is seen by obese people, and the adjustment function of fenestrations in relation to the white spots of lymphangiectasia.

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  • Development of Medaka NASH Model and Hepatocarcinogenesis

    Grant number:16K15424

    2016.4 - 2018.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    Terai Shuji

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    Grant amount:\3380000 ( Direct Cost: \2600000 、 Indirect Cost:\780000 )

    The development of Medaka NASH model was examined. The drR medaka was utilized to develop the model. High fsat diet was continuously administered to the model and the liver tissue, blood biochemistry were casrefully examined to deteremine whether the NASH model mimicking the condition in the human.
    The results showed that the successful development of the model. Following this success, the prevention of the progression of NASH in Medaka liver was assessed using SGLT2 inhibitor. Surprisingly, the SGLT2 inhibitor successfully inihibited the progression of NASH in these model.

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  • Analysis of the factors of malignant behavior in hepatic progenitor cell marker expressing hepatocellular carcinoma

    Grant number:15K08990

    2015.4 - 2018.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Tsuchiya Atsunori, TERAI Shuji, KOJIMA Yuichi, SEINO Satoshi

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    In this study we analyzed the expression of four hepatic progenitor cell markers in 251 hepatocellular carcinomas (HCCs) with their clinical data and tumor markers, and significance of the hepatic progenitor markers in HCC for prognosis. We elucidated that EpCAM expression, DCP>300 mAU/ml, age > 60, Child-Pugh sore grade B or C were independent prognostic factors of poor outcome and were used in a new scoring system for HCC prognosis after operation. Expression of two or more HPC markers was a significant predictor of poor HCC outcome and co-related with AFP and AFP-L3 levels, blood vessel invasion and differentiation of the tumor.

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  • Basic research to develop next generation cell therapy for improvement of liver fibrosis.

    Grant number:26293175

    2014.4 - 2017.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    TERAI Shuji, NISHINA Hiroshi, TABATA Yasuhiko, TOGUCHIDA Junya

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    Grant amount:\16640000 ( Direct Cost: \12800000 、 Indirect Cost:\3840000 )

    Decompensated liver cirrhosis often progresses even after treatment. Autologous bone marrow cells infusion (ABMi) therapy was developed for liver cirrhosis, however the most effective cells in the heterogeneous bone marrow cells, detail behavior of administrated cells, and detailed mechanism of improvement of liver fibrosis and promotion of liver regeneration have not been elucidated. In this study we elucidated that mesenchymal stem cells (MSCs) and induced bone marrow derived macrophages (id-BMMs) combination therapy effectively regressed liver fibrosis and promoted liver regeneration. Combination therapy using both id-BMMs and MSCs had synergistic effects, affecting the host cells in a liver cirrhosis mouse model. We also elucidated that a large number of id-BMMs, which had M2 phenotype and phagocytized hepatocyte debris, and few MSCs migrated to the fibrotic area in the liver. We believe that this fact is important for future cell therapy for decompensated liver cirrhosis.

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  • Development of Medaka Model for Analysis of Angiogenesis and Kupffer cell

    Grant number:25670370

    2013.4 - 2016.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    Terai Shuji, Kamimura Kenya, Fujisawa Koichi, Takami Taro, Yamamoto Naoki

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    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    Development of animal model for angiogenesis has been examined. Using Medaka as an animal model, we have successfully established the animal model which can be used for the study of angiogenesis and to analyze the vascular injury caused by the anti-tumor agents, such as Sorafenib. In addition, the Medaka model was used to examine the relationship between animal circadian rhythm and metabolism. Our results indicate that the Medaka can be used as a promising animal model.

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  • The analysis of small bone marrow drived liver repair cell

    Grant number:24590978

    2012.4 - 2015.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    YAMAMOTO Naoki, TERAI Shuji, TAKAMI Taro, FUJISAWA Koichi

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    Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )

    We developed the GFP/CCl4 model which monitor the GFP-positive bone marrow cell (BMC) repopulated under CCl4 induced liver cirrhosis mice.We found two kinds of GFP positive BMCs in recipient cirrhosis liver using IEM method. One group of GFP positive BMCs was similar to hepatocyte in size(15-30um) and located around fiber(MMP9 positive cell).The other group cells were small size (2-5microum) and located in destructive area(A6 positive cell, Liv2 positive cell). And EpCAM positive cells were included. These cells were circular forms and had high N/C ratio and smaller than hepatocyte. We separated EpCAM-positive and EpCAM-negative cells and then transplanted these cells into a continuous liver damaged model(CCl4 model). At 4 weeks after BMC transplantation, the ratio of liver fibrosis in EpCAM-negative cells injected liver was decreased better than EpCAM-positive cells.

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  • Development of the analytical method of the cancer stem cell using the ATP sensor in the cell

    Grant number:24659369

    2012.4 - 2014.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    FUJISAWA Koichi, TERAI Shuji, TAKAMI Taro, YAMAMOTO Naoki

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    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    We examined the analysis of energy metabolism of the ATP. Adenylate kinase isozyme expression was related to energy metabolism. In addition, an oxygen consumption rate changed by a knockdown of the adenylate kinase was evaluated by using the flux analyzer, and the change of the metabolic syndrome light included in TCA cycles such as the fumaric acid was recognized by the metabolome analysis, and importance of the adenylate kinase in the metabolism was shown.

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  • The development of new combination therapy with deferasirox and sorafenib on advanced hepatocellular carcinama

    Grant number:23590978

    2011 - 2013

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    YAMASAKI Takahiro, YAMAMOTO Naoki, TERAI Shuji, SAKAIDA Isao

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    Grant amount:\5200000 ( Direct Cost: \4000000 、 Indirect Cost:\1200000 )

    Sorafenib is expected to have a chemopreventive effect on hepatocellular carcinoma (HCC). However, there are limitations to its use because of adverse effects, including effects on liver function. We have reported that the iron chelator deferoxamine can prevent liver fibrosis and preneoplastic lesions. We investigated the influence of administering an oral iron chelator, deferasirox (DFX), on the effects of sorafenib. The combination of DFX+sorafenib markedly prevented liver fibrosis and preneoplastic lesions better than the other treatments. Furthermore, the combination therapy produced significantly fewer adverse effects such as body weight and hand-foot skin syndrome compared with the sorafenib group. The combination therapy with DFX and sorafenib may be a useful adjuvant therapy to prevent recurrence after curative treatment of HCC.

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  • Basic research for chronotherapy focused on liver regeneration andliver steatosis by circadian clock

    Grant number:23659398

    2011 - 2012

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    TERAI Shuji, YAMAMOTO Naoki, TAKAMI Taro, FUJISAWA Koichi, SAKAIDA Isao

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    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    Medaka with HFD showed high NASH activity score (NAS), suggesting that circadian rhythm change is related to NASH progression. The light system is closely related with chronic inflammation by light stimulation. Collaboration with Oklahoma university, we found that NASH medaka developed diabetic nephropathy. These data showedmedaka fish model is useful to analyze the mechanism of NASH and nephropathyand to develop a new chronotherapy.

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  • Both Herbal medicine Bofu-tsusho-san (TJ-62) and Dai-saiko-to (TJ-8) prevent liver fibrosis and hepatocarcinogenesis in rat liver cirrhosis.

    Grant number:22590657

    2010 - 2012

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    UCHIDA Kouichi, TERAI Syuji, YAMAMOTO Naoki, TAKAMI Taro

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    The aim of this study was to investigate whether both Dai-saiko-to (TJ-8) and Bofu-tsusho-san (TJ-62) have any influence on the development of preneoplastic lesions as well as liver fibrosis.Results: After 12 weeks, both TJ-8 and TJ-62 prevented fibrosis in a dose-dependent manner by Azan, Sirius Red, αSMA expression (p < 0.05). Hydroxyproline level in liver was decreased (mean value: CDAA+TJ-8 6.3 vs CDAA only 13.4 umol/Wg P

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  • The basic research of the development of future generation cell therapy used bone marrow derived liver repaid cell

    Grant number:22390150

    2010 - 2012

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    TERAI Shuji, ISHIKAWA Tsuyoshi, TAKAMI Taro, SAKAIDA Isao, UCHIDA Koichi, YAMAMOTO Naoki

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    Grant amount:\18720000 ( Direct Cost: \14400000 、 Indirect Cost:\4320000 )

    Our researches showed that autologous bone marrow derived cells (BMCs) were useful for liver regeneration therapy for liver cirrhosis. In these projects, we estimated characterization of bone marrow derived liver repair cells and demonstrated the mechanisms of liver repair by BMCs. We found that macrophage was effective to improve liver fibrosis in mice. In this project, we found that TNF signal is important to induce liver repair by BMC infusions. We found that bone marrow derived mesenchymal cells might be a new candidate-cell-fraction to repair liver fibrosis. Both TNF and Maid signal are important to regulate improvement of liver fibrosis by BMC infusion. These results are important to develop a new cell therapy using BMCs.

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  • Development of new gene transfer system for small fish

    Grant number:22659148

    2010 - 2011

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    SAKAIDA Isao, TERAI Shuji, YAMAMOTO Naoki, TAKAMI Taro, FUJISAWA Koichi

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    Grant amount:\3190000 ( Direct Cost: \2800000 、 Indirect Cost:\390000 )

    The possibility of gene therapy for zebrafish and medaka with hydrodynamic methods was examined. A condition setup for gene transfer was performed with GFP plasmid. We found few GFP positive cells in the liver. Gene transfer efficiency was small compared with the infusion of the mouse models.
    We established fish live fibrosis model for evaluation of liver fibrosis improvement. We found that high fat diet and carbon tetrachloride is not suitable for liver fibrosis induction and DEN treatment for two months is suitable for liver fibrosis.

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  • 非アルコール性脂肪性肝炎関連発癌に対する戦略的研究

    Grant number:21659189

    2009 - 2010

    System name:科学研究費助成事業

    Research category:挑戦的萌芽研究

    Awarding organization:日本学術振興会

    寺井 崇二, 山本 直樹, 高見 太郎

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    Grant amount:\3100000 ( Direct Cost: \3100000 )

    我々はHuman Homologue of Maid(HHM)が、肝臓特異的な遺伝子発現制御、ヒト肝前癌性病変のマーカーになりうることについて報告してきた。また高分化型肝細胞癌は脂肪沈着像を示すことより、非アルコール性脂肪肝炎関連発癌機構の解明は重要である。本研究では非アルコール性脂肪肝炎状態の病態解明、さらにHHMを用いた発癌制御、線維化抑制について検討した。研究成果として小型魚類のメダカ非アルコール脂肪肝炎モデルを作成に世界で初めて成功し報告した(DMM2010)。さらにこの実験モデル系を用いて薬物スクリーニングも実施が可能であることを報告した(Cell & Tissue Res 2011)。またDEN処理により得られたゼブラフィッシュ肝でMaidは癌前癌性病変で発現が増加したことが確認できた。一方、肝細胞癌では発現が低下していた。
    Maidを過剰発現させたトランスジェニックメダカをDEN処理したところ、BrdU陽性細胞数が少なかった。MaidKOマウスを作製し四塩化炭素を投与したところ、肝線維化亢進が認められ、Ki67陽性細胞の増加、EpCAM陽性細胞は減少が認められた。Maidは肝発癌制御に関与していると考えられており、四塩化炭素投与で細胞増殖性が亢進していること、メダカでのMaidの過剰発現で細胞増殖性の低下がみられることから、Maidは細胞増殖抑制に働くことが考えられる。さらにDEN処理で得られた肝組織でもFociでは発現が高く、HCCなどの癌部では発現が低いことが免疫組織染色で確認できたことからも発癌制御に関わっていると考えられた。このように新たな非アルコール性脂肪肝炎モデルの確立、またMaid分子の機能解析が明らかになった。これらの成果はさらに、非アルコール性脂肪肝炎関連発癌の制御機構の解明に、小型魚類を用いた本研究実績が役立つと考えられた。

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  • Development of a novel therapy using the iron chelator for advanced hepatocellular carcinoma

    Grant number:20590783

    2008 - 2010

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    YAMASAKI Takahiro, SAKAIDA Isao, TERAI Shuji, YAMAMOTO Naoki

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    We investigated the anti-tumor effect and the fibrosing suppression effect of the iron chelator deferoxamine (DFO) in vitro and in the model rats using diethylnitrosamine and choline-deficient L-amino acid-defined diet. We proved the antiproliferative effect of DFO in hepatoma cell line. In the vivo model, the body weight and liver weight in the DFO therapy group was significantly lower than those in the control group, and the tumor growth was significantly suppressed in the DFO therapy group comparing the control group. The iron chelator has few DNA damage and has the potential of hepatma specific action different from the traditional anticancer drugs. In this study, we founded that the iron chelator has the potential of a novel antiproliferative drug in patients who had advanced hepatocellular carcinoma and were non-responders for anticancer drugs.

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  • 血管観察トランスジェニックメダカを用いた非アルコール性脂肪性肝炎の病態解析

    Grant number:20659116

    2008 - 2009

    System name:科学研究費助成事業

    Research category:挑戦的萌芽研究

    Awarding organization:日本学術振興会

    坂井田 功, 寺井 崇二, 内田 耕一, 山本 直樹

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    Grant amount:\3200000 ( Direct Cost: \3200000 )

    メダカにハイファットダイエット(HFD)食投与することでまずNASHモデルを作成した。HFD食投与後2週目にはメダカ肝細胞内にFli脂肪滴を認め、4、8週目には脂肪沈着は著明となり、肝細胞の風船様変化等ヒトNASHに類似した組織像を認めた。D-PAS染色の解析では、時間経過とともにD-PAS陽性細胞は増加し、時間経過とともにNASH score(NAS)の上昇を認めた。またメダカの採血方法を昨年度で確立させたので,肝機能・脂質など様々な項目を測定し,このモデルにおいて肝機能障害,血糖値の上昇,中性脂肪・総コレステロール等の上昇を確認できた。今回、出生後3ヶ月のcabメダカにHFD32を4週間与えて作成したメダカ脂肪肝モデルを作成し、AT2拮抗剤であるテルミサルタンの投与を開始し、HFD+テルミサルタン(Tel投与)群とHFD投与群で様々な比較検討を行った。また血管観察モデルのFLi-GFP TGメダカも用いて解析するとともに、Tilling法にてTGF-betaの下流の分子のMaidのゼブラフィッシュの変異体のスクリーニングも実施した。(結果)テルミサルタン(Tel)群では脂肪化、炎症細胞浸潤のいずれにおいても、HFD群を比較して抑制効果を認め、NASについてもscoreを減少させた。血液検査データ(ALT、TG)については、HFD群とTel群両群で、差を認めなかった。CD68免疫染色ではHFD群において、風船様変化を呈した組織に陽性細胞を観察した。同組織におけるTUNEL染色ではapoptosis細胞は優位ではなかった。8OHDG免疫染色ではHFD群で陽性細胞を認め、Tel群では抑制されていた。TUNEL染色では脈管周囲に陽性となる細胞を認めた。Tel群ではHFD群と比較し、apoptosisは抑制されていた。RT-PCR解析では、Tel群でPPAR-γの発現が増加していた。DNA-chip解析では、酸化ストレスやERストレスに関連した遺伝子の増減変化を確認した。RT-PCR解析では、GRP78あるいはGRP94についてはHFD群、Tel群でその発現に差はなく、splicing-XBP1についても両群で2週目にその発現が増加していた。脂肪酸合成系酵素であるACCの発現は両群で低下していた。一方、β酸化系酵素であるCPT1・ACO1についてはHFD群と比較しTel群で増加していた。今回の解析ではテルミサルタン投与によってNASHの病態を抑制する可能性が示唆された。一方でNASH病態の進行に伴い肝血管系の変化を確認した。

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  • Mechanism of fibrolysis and effect on cancer by autologus bone marrow cell infusion therapy for liver cirrhosis

    Grant number:19390199

    2007 - 2009

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    SAKAIDA Isao, YAMASAKI Takahiro, TERAI Shuji, YAMAMOTO Naoki

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    Grant amount:\18330000 ( Direct Cost: \14100000 、 Indirect Cost:\4230000 )

    We have previously reported the effects of autologous bone marrow cell (BMC) infusion (ABMi) therapy in liver cirrhosis patients.The results showed that cell therapy using autologous BMC has the potential to become an effective treatment for patients with liver failure due to advanced liver cirrhosis.To analyze the cellular phenomena of involved in this process and the mechanism of dissolve in fibrosis, we checked the damaged liver using electron microscopy and estimated some kind of serum cytokines. We showed that G-CSF and IL1b is important and concerned about the proliferation of BMC in damage liver. We showed continuous high XBP1 and GRP78 expression might be essential for the survival and proliferation of BMC in liver damage environment.

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  • The effect of Herbal medicine Bofu-tsusho-san(TJ-62)and the Crude Drugs with hepatic steatosis

    Grant number:19590693

    2007 - 2008

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    UCHIDA Koichi, TERAI Syuji, YAMAMOTO Naoki, IIZUKA Norio, SAKAIDA Isao

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • 癌幹細胞の発生分化制御機構の解析

    Grant number:18659209

    2006 - 2007

    System name:科学研究費助成事業

    Research category:萌芽研究

    Awarding organization:日本学術振興会

    坂井田 功, 寺井 崇二, 内田 耕一

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    Grant amount:\3300000 ( Direct Cost: \3300000 )

    我々の今までの解析よりHLH型転写制御分子HHMがヒト前癌性病変におけるマーカー蛋白になる可能性があり、HHM蛋白の発現制御、その機能解析を行っていくことで肝発癌における"肝幹細胞"と"癌幹細胞"の違いについて明らかにできると考え研究を進めてきた。また新規化合物の化学構造の解析だけでは生体内における薬物動態、効果の評価は困難であり新たな薬物スクリーニングシステムの開発が必要であると考えた。マウス、ラットの系は個体が大きく、多種の新規化合物を用いた大規模な抗癌物質のスクリーニングには不向きである。その問題点を解決するため、我々はヒトと同じ小型の脊椎動物であるメダカモデルを用いて肝発癌モデルを作成することで新たなスクリーニングシステムを構築したいと考え研究を行なった。今年度は研究成果として、HHMと同じHLH型転写制御分子のId2の肝星細胞の増殖・制御機構の解析を行なうとともに、メダカモデルを用いて肝硬変モデル、肝線維化モデルを確立し、その成果をアジア太平洋肝臓会議、アメリカ肝臓学会で報告した。これらのモデルは肝発癌を誘導する周辺環境の誘導モデルになると考える。

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  • Basic studies for the development of efficient liver regenerative therapy using bone marrow cells

    Grant number:18590737

    2006 - 2007

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    TERAI Shuji, SAKAIDA Isao, UCHIDA Koichi

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    Grant amount:\4010000 ( Direct Cost: \3500000 、 Indirect Cost:\510000 )

    We have developed an in vivo mouse model, the GFP/CC14 model, and have reported that transplanted GFP-positive bone marrow cells (BMCs) differentiate into hepatocytes and improve /CC14-induced cirrhosis. We have also reported that fibroblast growth factor 2 (FGF2) facilitated the differentiation of transplanted BMCs into hepatocytes. However, it is unclear the mechanism(s) of the differentiation from transplanted BMCs into hepatocytes. In 2006, our studies demonstrated that administration of FGF2 in combination with bone marrow transplantation (BMT) synergistically activated tumor necrosis factor-alpha signaling and significantly improved liver function and prognosis more than BMC infusion alone, suggesting that FGF2 had an important role in liver regeneration. Next, in 2007, we analyzed why the injected BMC are resistant to /CC14 damage and subsequently improve the local microenvironment in damaged liver. To analyze the cellular phenomena involved in this process, we studied the damaged liver using electron microscopy. We found that /CC14 caused rough endoplasmic reticule to swell in hepatocytes. To analyze the gene expression patterns associated with this process, we conducted PCR-selected suppressive subtractive hybridization. We found that expression levels of HSP84, HSP40, and XBPI differed markedly between control liver and liver infused with BMC. Immunohistochemical staining revealed that expression levels of HSP84 and HSP40 were markedly higher in the early phase of differentiation immediately after BMC infusion, but decreased over time. XBPI expression remained high during the late phase, and GRP78 expression increased with XBPI activation. We also found that GFP-positive BMC expressed XBPI and GRP78. XBP1 and GRP78 are associated with ER stress. Thus, continuous high XBPI and GRP78 expression might be essential for the survival and proliferation of BMC in a CC14-induced persistent liver damage environment. These basic studies are important for the development of an effective autologous bone marrow cell infusion (ABMI) therapy for patients with liver cirrhosis.

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  • Analysis of the serum factor which promotes the repopulation and differentiation of the bone marrow cell into hepatocyte.

    Grant number:16390211

    2004 - 2006

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    OKITA Kiwamu, SAKAIDA Isao, TERAI Shuji

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    Grant amount:\14100000 ( Direct Cost: \14100000 )

    We developed the GFP/CC14 model to evaluate the differentiation of bone marrow cell into hepatocyte. We found that bone marrow cell (BMC) were repopulated into the damaged liver and differentiated into albumin-producing hepatocyte In this condition, liver fibrosis was also significantly improved and survival rate was improved by BMC infusion. Depend on these results, we started the clinical study : Autologous BMC infusion therapy for liver cirrhosis patients (Stem Cells 2006). Here we did the proteomics analysis to find serum factor that promote repopulation and differentiation of BMC into hepatocyte. Apolipoprotein was increased significantly in the serum after BMC infusion. We also analyzed which growth factors regulate the repopulation and differentiation of BMC. We found that FGF2 was important growth factor to repopulate and differentiation of BMC into hepatocyte. On the other hands, we also examine the mechanism of the differentiation of liver stem cell. Previously we also cloned Human Homologue of Maid as a regulator of differentiation of hepatic stem cell. In this study, we started to make the Maid KO mouse to analyze how Maid regulate the differentiation of BMC into hepatocyte.

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  • 骨髄細胞から肝細胞への分化を制御する遺伝子群の同定プロジェクト

    Grant number:15790348

    2003 - 2004

    System name:科学研究費助成事業

    Research category:若手研究(B)

    Awarding organization:日本学術振興会

    寺井 崇二

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    Grant amount:\3500000 ( Direct Cost: \3500000 )

    我々は、自己骨髄細胞を用いた肝臓再生療法の臨床応用を進める基盤モデルとして骨髄細胞から肝細胞への分化評価モデル(GFP/CC14モデル)の開発し、骨髄細胞が持続的肝障害の肝硬変時に肝臓に遊走され肝細胞へ分化・増殖することを明らかにした(JB2003、特公2003-70377)。さらにこのモデルの解析を通じ、骨髄細胞移植により生存率の回復、また肝線維化の改善を発見した(Hepatology 2004,この発見はWiley社よりHepatology News Alert記事とし世界に発信された)。さらに骨髄細胞を用いた再生療法をより効率的に行うための骨髄細胞の肝細胞への分子制御機構を骨髄細胞の肝細胞への分化評価モデルGFP/CC14モデルの解析を通じて、骨髄由来細胞の肝細胞への分化過程に関与する遺伝子群を,DNA-ChipとMicroarray-Self Organization Map(SOM)解析を用い骨髄細胞の投与により誘導された遺伝子群の抽出を目指した。その結果、骨髄細胞の肝細胞への分化は初期には形態形成に関与するHOX,HLH型転写制御分子が関与し、後期においては肝細胞の代謝に関与する分子が誘導されていることが明らかになった(FEBS letters2004)。この結果は骨髄細胞の肝細胞への分化において、発生と同じ遺伝子群が関与することが明らかになった。生データはhttp://liver-roject.med.yamaguchi-u.ac.jp/researchのサイトでホームページにて公開している。)。

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  • The analysis for proliferation and differentiation of hepatic stem cells

    Grant number:13470121

    2001 - 2003

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    OKITA Kiwamu, TERAI Shuji, SAKAIDA Isao

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    Grant amount:\16300000 ( Direct Cost: \16300000 )

    Here we found that persistent injury induced efficient trans-differentiation of BMCs into functional hepatocytes. Liver cirrhosis mice induced by carbon tetrachloride were injected with 1x10^5 non-treated green fluorescent protein (GFP)-positive BMCs via tall vein. In these mice, transplanted GFP-positive BMCS efficiently migrated into the peri-portal area of liver lobules after one day and repopulated one-fourth of the recipient liver by 4 weeks. In contrast, no GFP-positive BMCs were detected following transplantation into control mice. with undamaged livers. BMCs trans-differentiated into functional mature hepatocytes via immature hepatoblasts. Serum albumin was significantly elevated to compensate for chronic liver failure by BMC transplantation. These results showed that the recipient condition and microenvironments are key factors for successful cell therapy using BMC. We named this model as a GFP/CC14 model. As the next step, we developed a new monoclonal antibody, anti-Liv8 using mouse fetal liver antigen. On embryonic day 11.5, Liv8-positive cells were seen in the liver of wild-tape, but not AML1 knockout mice, which lack the hematopoietic system. Liv8-positive cells accounted for 32% of the BMC in adult mice and included CD45-positive cells. We separated Liv8-positive or Liv8-negative cells using Auto Magnetic Cell Sorting system, and then transplanted these cells to a continuous liver damaged model. After one week, there was no marked difference in the initial colonization of BMC in the liver between recipients of Liv8-positive and Liv8-negative cells, but at 4 weeks more efficient BMC trans-differentiation into hepatocytes was seen with Liv8-negative cells. Now we are trying to identify the antigen of anti-Liv8. These analysis will be useful to develop all efficient cell therapy to repair damaged liver. On the other hands, we identified that new protein. Human homologue of maid (HHM) is a helix-loop-helix (HLH) transcriptional regulatory protein that is involved in the hepatic stem cell development and differentlation. We analyzed the potential involvement of HHM in hepatocarcinogenesis. We assessed HHM expression in the chorine deficient L-amino acid defined (CDAA) diet model of rat hepatocarcinogenesis by in situ hybridization DISH), and human HCC samples by immunohistochemical analysis. High HHM expression was seen in foci and HCC. These results suggested that HHM may be a useful marker protein to detect initiation of hepatocarcinogenesis

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  • 骨髄血投与による肝臓リモデリングの基礎的検討

    Grant number:13770262

    2001 - 2002

    System name:科学研究費助成事業

    Research category:若手研究(B)

    Awarding organization:日本学術振興会

    寺井 崇二

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    Grant amount:\2800000 ( Direct Cost: \2800000 )

    平成13年度までの研究にてGreen Fluorescent Protein (GFP)トランスジェニックマウスを用い骨髄細胞からの肝細胞への分化増殖のin vivo評価モデルを世界に先駆け開発した(GFP/CCl4モデル)。このモデルにおいては,持続的な四塩化炭素(CCl4)投与による肝障害時に,骨髄細胞から肝細胞への分化・増殖が確認され,骨髄細胞投与後,肝臓内の骨髄細胞は25%まで増加し,肝細胞索構造を構築した(特願2001-271240号)。この研究成果については2年1回開かれる2002 FASEB Summer Research Conference"Mechanism of liver growth, differentiation and molecular pathogenesis of hepatic diseaseにて招待講演を行った。さらにこのモデルの解析の結果、骨髄細胞投与により、血清アルブミン値の回復、生存率も有意に骨髄細胞の非投与群に比べ有意差を持って改善していた。最近問題になっている、この分化転換において細胞融合の関与は少ないと考えられた。また肝線維化も有意に改善していた(この結果については2002年度アメリカ肝臓病学会総会プレナリーセッション口頭発表)。これらの結果より考え、自己骨髄細胞を用いた肝臓再生療法は臨床応用可能な次世代の移植医療になりえると考えられた。さらに東京大学薬学系研究科生理化学教室の仁科博史博士との共同研究にて、胎児肝特異的な分子マーカーを単離する目的で、胎生期11.5日(E11.5)のマウス肝を抗原にして複数のモノクローナル抗体を作製して解析してきた。このうち抗Liv2と命名した抗体は、マウス発生期に出現する肝幹細胞である肝芽細胞を特異的に認識する。このLiv2陽性細胞は骨髄差wartの肝細胞への分化過程にて出現する。また抗Liv2抗体作成時、同時に作成した抗Liv8抗体は、大動脈・生殖隆起・中腎(AGM)領域の血管内皮細胞や胎児肝領域に流入する血液幹細胞に加え、成体骨髄中の細胞も認識することから、胎児肝における二次(成体型)造血や成体の造血の場である骨髄を解析する有用なツールになることが期待されている(第25回日本分生物学会ワークショップにて口頭発表)。我々は骨髄中に存在する肝幹細胞の同定のため、あらたに作成したLiv8抗体を解析した。この結果Liv8陽性、陰性細胞の移植では、陰性群において高率に肝細胞への分化転換が確認でき、この結果より骨髄中のLiv8陰性細胞群が再生療法に有用な細胞群と考えられた。

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Teaching Experience

  • 医学序説 II

    2022
    Institution name:新潟大学

  • 臨床実習IIA(clinical clerkship)

    2022
    -
    2023
    Institution name:新潟大学

  • 医学序説 I

    2021
    Institution name:新潟大学

  • 臓器別講義・演習Ⅱ

    2020
    Institution name:新潟大学

  • 臨床医学講義(集中)

    2020
    Institution name:新潟大学

  • 医学序説 II

    2020
    Institution name:新潟大学

  • 内科学3

    2017
    -
    2018
    Institution name:新潟大学

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