2021/05/15 更新

写真a

サジ エツジ
佐治 越爾
SAJI Etsuji
所属
医歯学総合病院 脳神経内科 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2013年3月   新潟大学 )

研究分野

  • ライフサイエンス / 神経内科学

経歴

  • 新潟大学   医歯学総合病院 脳神経内科   助教

    2019年4月 - 現在

  • 新潟大学   医歯学総合病院 神経内科   助教

    2017年11月 - 2019年3月

  • 新潟大学   医歯学総合病院 高次救命災害治療センター   特任助教

    2017年4月 - 2017年10月

  • 新潟大学   医歯学総合病院 神経内科   特任助教

    2015年4月 - 2017年3月

 

論文

  • The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells. 査読 国際誌

    Joana Machado-Santos, Etsuji Saji, Anna R Tröscher, Manuela Paunovic, Roland Liblau, Galina Gabriely, Christian G Bien, Jan Bauer, Hans Lassmann

    Brain : a journal of neurology141 ( 7 ) 2066 - 2082   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so far little is known regarding the phenotype and function of these infiltrating lymphocyte populations. In this study, we performed an in-depth phenotypic characterization of T and B cell infiltrates in a large set of multiple sclerosis cases with different disease and lesion stages and compared the findings with those seen in inflammatory, non-inflammatory and normal human controls. In multiple sclerosis lesions, we found a dominance of CD8+ T cells and a prominent contribution of CD20+ B cells in all disease courses and lesion stages, including acute multiple sclerosis cases with very short disease duration, while CD4+ T cells were sparse. A dominance of CD8+ T cells was also seen in other inflammatory controls, such as Rasmussen's encephalitis and viral encephalitis, but the contribution of B cells in these diseases was modest. Phenotypic analysis of the CD8+ T cells suggested that part of the infiltrating cells in active lesions proliferate, show an activated cytotoxic phenotype and are in part destroyed by apoptosis. Further characterization of the remaining cells suggest that CD8+ T cells acquire features of tissue-resident memory cells, which may be focally reactivated in active lesions of acute, relapsing and progressive multiple sclerosis, while B cells, at least in part, gradually transform into plasma cells. The loss of surface molecules involved in the egress of leucocytes from inflamed tissue, such as S1P1 or CCR7, and the upregulation of CD103 expression may be responsible for the compartmentalization of the inflammatory response in established lesions. Similar phenotypic changes of tissue-infiltrating CD8+ T cells were also seen in Rasmussen's encephalitis. Our data underline the potential importance of CD8+ T lymphocytes and B cells in the inflammatory response in established multiple sclerosis lesions. Tissue-resident T and B cells may represent guardians of previous inflammatory brain disease, which can be reactivated and sustain the inflammatory response, when they are re-exposed to their specific antigen.

    DOI: 10.1093/brain/awy151

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  • Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis. 査読 国際誌

    Susanne Laukoter, Helmut Rauschka, Anna R Tröscher, Ulrike Köck, Etsuji Saji, Kurt Jellinger, Hans Lassmann, Jan Bauer

    Acta neuropathologica133 ( 4 ) 613 - 627   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    During the appearance of human immunodeficiency virus infection in the 1980 and the 1990s, progressive multifocal leukoencephalopathy (PML), a viral encephalitis induced by the JC virus, was the leading opportunistic brain infection. As a result of the use of modern immunomodulatory compounds such as Natalizumab and Rituximab, the number of patients with PML is once again increasing. Despite the presence of PML over decades, little is known regarding the mechanisms leading to death of infected cells and the role the immune system plays in this process. Here we compared the presence of inflammatory T cells and the targeting of infected cells by cytotoxic T cells in PML, herpes simplex virus encephalitis (HSVE) and cytomegalovirus encephalitis (CMVE). In addition, we analyzed cell death mechanisms in infected cells in these encephalitides. Our results show that large numbers of inflammatory cytotoxic T cells are present in PML lesions. Whereas in HSVE and CMVE, single or multiple appositions of CD8+ or granzyme-B+ T cells to infected cells are found, in PML such appositions are significantly less apparent. Analysis of apoptotic pathways by markers such as activated caspase-3, caspase-6, poly(ADP-ribose) polymerase-1 (PARP-1) and apoptosis-inducing factor (AIF) showed upregulation of caspase-3 and loss of caspase-6 from mitochondria in CMVE and HSVE infected cells. Infected oligodendrocytes in PML did not upregulate activated caspase-3 but instead showed translocation of PARP-1 from nucleus to cytoplasm and AIF from mitochondria to nucleus. These findings suggest that in HSVE and CMVE, cells die by caspase-mediated apoptosis induced by cytotoxic T cells. In PML, on the other hand, infected cells are not eliminated by the immune system but seem to die by virus-induced PARP and AIF translocation in a type of cell death defined as parthanatos.

    DOI: 10.1007/s00401-016-1642-1

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  • Clinicopathological features in anterior visual pathway in neuromyelitis optica 査読

    Mariko Hokari, Akiko Yokoseki, Musashi Arakawa, Etsuji Saji, Kaori Yanagawa, Fumihiro Yanagimura, Yasuko Toyoshima, Kouichirou Okamoto, Satoshi Ueki, Tetsuhisa Hatase, Riuko Ohashi, Takeo Fukuchi, Kohei Akazawa, Mitsunori Yamada, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    ANNALS OF NEUROLOGY79 ( 4 ) 605 - 624   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    ObjectiveNeuromyelitis optica spectrum disorder (NMOsd) is an autoimmune disorder of the central nervous system characterized by aquaporin-4 (AQP4) autoantibodies. The aim of this study was to elucidate the characteristics of involvement of the anterior visual pathway (AVP) and neurodegeneration via glia-neuron interaction in NMOsd.
    MethodsThirty Japanese patients with serologically verified NMOsd were assessed with a neuro-ophthalmological study. Using 27 tissue blocks from 13 other cases of NMOsd, we performed neuropathological analysis of glial and neuroaxonal involvement in the AVP.
    ResultsThe AVP involvement in NMOsd was characterized by the following, compared to multiple sclerosis: (1) longitudinally extensive optic neuritis (ON); (2) more severe visual impairment and worse prognosis for ON; (3) unique AQP4 dynamics, including loss of AQP4 immunoreactivity on astrocytes with complement activation in ON lesions, loss of AQP4 immunoreactivity on Muller cells with no deposition of complement in the retinas, and densely packed AQP4 immunoreactivity on astrocytes in gliosis of secondary anterograde/retrograde degeneration in the optic nerves and retinal nerve fiber layer (RNFL); and (4) more severe neurodegeneration, including axonal accumulation of degenerative mitochondria and transient receptor potential melastatin 4 channel with complement-dependent astrocyte pathology in ON lesions, mild loss of horizontal cells, and RNFL thinning and loss of ganglion cells with abundance of AQP4(+) astrocytes, indicating secondary retrograde degeneration after ON.
    InterpretationSevere and widespread neuroaxonal damage and unique dynamics of astrocytes/Muller cells with alterations of AQP4 were prominent in the AVP and may be associated with poor visual function and prognosis in NMOsd. Ann Neurol 2016;79:605-624

    DOI: 10.1002/ana.24608

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  • Gray matter lesions and cognitive impairment in multiple sclerosis 査読

    Izumi Kawachi, Etsuji Saji, Masatoyo Nishizawa

    Clinical Neurology54 ( 12 ) 1060 - 1062   2014年

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    記述言語:日本語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:Societas Neurologica Japonica  

    Multiple sclerosis (MS) has long been considered to be the autoimmune disease that primarily affects oligodendrocyte and myelin in the white matter (WM) of the CNS. However, renewed interest in the gray matter (GM) pathology including cortical and deep GM of MS is emerging. Radiological and pathological assessments demonstrate that substantial cortical demyelination is prominent in all stages or courses of MS, and cortical neurodegeneration is also present in even normal-appearing GM in MS. Patients with MS have cognitive impairment as represented by the latent start of impairment from the very early stage of the disease course, and not only WM lesions but also GM lesions might be good predictors for cognitive impairment in MS. Although the cause of the GM lesions in MS has not been fully determined, an increase in knowledge of the structure of GM lesions in MS brains will result in more targeted therapeutic approaches to the disease.

    DOI: 10.5692/clinicalneurol.54.1060

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  • Hypertrophic pachymeningitis: Significance of myeloperoxidase anti-neutrophil cytoplasmic antibody 査読

    Akiko Yokoseki, Etsuji Saji, Musashi Arakawa, Takayuki Kosaka, Mariko Hokari, Yasuko Toyoshima, Kouichirou Okamoto, Shigeki Takeda, Kazuhiro Sanpei, Hirotoshi Kikuchi, Shunsei Hirohata, Kouhei Akazawa, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    Brain137 ( 2 ) 520 - 536   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press  

    The aim of this study was to elucidate the characteristics, pathogenesis and treatment strategy of hypertrophic pachymeningitis that is associated with myeloperoxidase anti-neutrophil cytoplasmic antibody (ANCA). We retrospectively investigated clinical, radiological, immunological and pathological profiles of 36 patients with immune-mediated or idiopathic hypertrophic pachymeningitis, including 17 patients with myeloperoxidase-ANCA, four patients with proteinase 3-ANCA, six patients with other immune-mediated disorders, and nine patients with 'idiopathic' variety. Myeloperoxidase-ANCA-positive hypertrophic pachymeningitis was characterized by: (i) an elderly female predominance
    (ii) 82% of patients diagnosed with granulomatosis with polyangiitis (previously known as Wegenervs granulomatosis) according to Watts' algorithm
    (iii) a high frequency of patients with lesions limited to the dura mater and upper airways, developing headaches, chronic sinusitis, otitis media or mastoiditis
    (iv) a low frequency of patients with the 'classical or generalized form' of granulomatosis with polyangiitis involving the entire upper and lower airways and kidney, or progressing to generalized disease, in contrast to proteinase 3-ANCA-positive hypertrophic pachymeningitis
    (v) less severe neurological damage according to the modified Rankin Scale and low disease activity according to the Birmingham Vasculitis Activity Score compared with proteinase 3-ANCA-positive hypertrophic pachymeningitis
    (vi) increased levels of CXCL10, CXCL8 and interleukin 6 in cerebrospinal fluids, and increased numbers of T cells, neutrophils, eosinophils, plasma cells and monocytes/macrophages in autopsied or biopsied dura mater with pachymeningitis, suggesting T &lt
    inf&gt
    H&lt
    /inf&gt
    1-predominant granulomatous lesions in hypertrophic pachymeningitis, as previously reported in pulmonary or renal lesions of granulomatosis with polyangiitis
    and (vii) greater efficacy of combination therapy with prednisolone and cyclophosphamide compared with monotherapy with prednisolone. Proteinase 3-ANCA may be considered a marker for more severe neurological damage, higher disease activity and a higher frequency of the generalized form compared with myeloperoxidase-ANCA-positive hypertrophic pachymeningitis. However, categorization into 'granulomatosis with polyangiitis' according to Watts' algorithm and immunological or pathological features were common in both proteinase 3- and myeloperoxidase-ANCA-positive hypertrophic pachymeningitis. These data indicate that most patients with myeloperoxidase-ANCA-positive hypertrophic pachymeningitis should be categorized as having the central nervous system-limited form of ANCA-associated vasculitis, consistent with the concept of ophthalmic-, pulmonary- or renal-limited vasculitis. © 2013 The Author (2013).

    DOI: 10.1093/brain/awt314

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  • Cognitive impairment and cortical degeneration in neuromyelitis optica 査読

    Etsuji Saji, Musashi Arakawa, Kaori Yanagawa, Yasuko Toyoshima, Akiko Yokoseki, Kouichirou Okamoto, Mika Otsuki, Kohei Akazawa, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    Annals of Neurology73 ( 1 ) 65 - 76   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective: Neuromyelitis optica spectrum disorder (NMOsd) is an inflammatory and demyelinating syndrome characterized by optic neuritis and myelitis. Several magnetization transfer magnetic resonance imaging (MRI) studies have revealed abnormalities in normal-appearing gray matter in NMOsd. The aim of this study is to elucidate the characteristics and pathogenesis of cognitive impairment and neurodegeneration in NMOsd brains. Methods: Fourteen Japanese patients with serologically verified NMOsd, 17 patients with multiple sclerosis (MS), and 37 healthy controls were assessed with the Rao's Brief Repeatable Battery of Neuropsychological Tests (BRBN). Using 128 tissue blocks from 6 other cases of NMOsd, 3 cases of MS, and 4 controls without central nervous system involvement, we performed quantitative analysis of cortical neuronal loss and layer-specific changes in NMOsd. Results: In BRBN assessments, 57% of NMOsd patients and 47% of MS patients had impaired performance on at least 3 cognitive tests. Cognitive impairment in NMOsd was common even in the limited form of disease, indicating that NMOsd may progress insidiously from early stages of disease. Neuropathological assessments showed neuronal loss in cortical layers II, III, and IV, with nonlytic reaction of aquaporin-4 (AQP4)-negative astrocytes in layer I, massive activated microglia in layer II, and meningeal inflammation in NMOsd brains. All NMO cases showed no evidence of cortical demyelination. Interpretation: We demonstrate cognitive impairment and substantial cortical neuronal loss with unique AQP4 dynamics in astrocytes in NMOsd. These data indicate pathological processes consisting not only of inflammatory demyelinating events characterized by pattern-specific loss of AQP4 immunoreactivity but also cortical neurodegeneration in NMOsd brains. Copyright © 2012 American Neurological Association.

    DOI: 10.1002/ana.23721

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  • Relapse of multiple sclerosis in a patient retaining CCR7-expressing T cells in CSF under fingolimod therapy 査読

    Akiko Yokoseki, Etsuji Saji, Musashi Arakawa, Mariko Hokari, Takanobu Ishiguro, Fumihiro Yanagimura, Tomohiko Ishihara, Kouichirou Okamoto, Masatoyo Nishizawa, Izumi Kawachi

    Multiple Sclerosis Journal19 ( 9 ) 1230 - 1233   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor, and it traps lymphocytes in secondary lymphoid organs and precludes their migration into the central nervous system. We report the case of a patient who suffered a relatively severe relapse of multiple sclerosis (MS) during the initial 3 months of fingolimod therapy, with retention of CCR7 expression on CD4+ T cells in the cerebrospinal fluid (CSF) despite decreased numbers of lymphocytes and decreased expression of CCR7 on CD4+ T cells in the blood. These data suggest that fingolimod may cause differential effects on the CSF and blood lymphocytes of patients with MS during the initial months of therapy. © The Author(s) 2013.

    DOI: 10.1177/1352458513481395

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  • Reduced bowel sounds in Parkinson's disease and multiple system atrophy patients 査読

    Tetsutaro Ozawa, Etsuji Saji, Ryuji Yajima, Osamu Onodera, Masatoyo Nishizawa

    CLINICAL AUTONOMIC RESEARCH21 ( 3 ) 181 - 184   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER HEIDELBERG  

    Digital auscultation of bowel sounds was performed in newly diagnosed, drug-na < ve patients with Parkinson's disease (PD) (n = 10), multiple system atrophy (MSA) (n = 12), progressive supranuclear palsy/corticobasal degeneration (PSP/CBD) (n = 7), and control subjects (n = 18). The number of bowel sounds per minute and the integrated time of bowel sounds were significantly lower in PD and MSA patients than in control subjects. Reduced bowel sounds may herald compromised gastrointestinal motility in patients with PD and MSA.

    DOI: 10.1007/s10286-010-0102-6

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  • Treatment responsive opsoclonus-ataxia associated with ovarian teratoma 査読

    I. Kawachi, E. Saji, Y. Toyoshima, J. Dalmau, M. Nishizawa

    Journal of Neurology, Neurosurgery and Psychiatry81 ( 5 ) 581 - 582   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/jnnp.2009.177261

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  • Diagnosis and Management of Paraneoplastic Neurological Syndromes 査読

    Etsuji Saji, Izumi Kawachi, Masatoyo Nishizawa

    Brain and Nerve62 ( 4 ) 319 - 330   2010年4月

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    記述言語:日本語  

    Paraneoplastic neurological syndromes (PNS) are infrequent tumor-related disorders that are not caused by direct tumor invasion or metastases, metabolic and nutritional deficits, infections, coagulopathy, or the side effects of cancer treatment. PNS can affect any part of the central and peripheral nervous systems, the neuromuscular junction, or muscles. Because the onset of PNS often antedates the diagnosis of an underlying cancer, it is difficult to establish a definitive early diagnosis. Therefore, it is important for neurologists to consider the possibility of PNS when rapidly progressive neurological syndromes cannot be explained by other causes. Detection of onconeural antibodies is useful for diagnosing PNS, and detection of specific antibodies can aid the identification of the underlying tumor. However, not all patients with PNS have onconeural antibodies, and not all patients with onconeural antibodies have PNS. Although PNS are considered to be mediated by the immune system, various forms of immunotherapy have yielded disappointing results, with some exceptions (i.e., PNS cases with antibodies against neuronal cell-surface antigens such as N-methyl-D-aspartate receptors). The lack of clinical trials due to the rarity of patients with PNS makes it difficult to test the efficacy of immunomodulatory treatment. Rapid detection and immediate treatment of the underlying tumor is an important approach that offers the highest chances of improvilng or stabilizing the syndrome before irreversible neuronal damage occurs. In this review, we discuss the diagnostic criteria and management of PNS based on the PNS Euronetwork and other reports.

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  • 再発性多発性軟骨炎との関与が疑われた髄膜脳炎の68歳女性例 査読

    佐藤 迪夫, 佐藤 晶, 佐治 越爾, 五十嵐 修一, 山崎 元義

    臨床神経学49 ( 10 ) 679 - 679   2009年10月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • Aortocoronary dissection complicated with percutaneous coronary intervention: A case report 査読

    Kazuyuki Ozaki, Takaaki Kubo, Etsuji Saji, Keita Ohtaki, Hidehira Fukaya, Yoshifusa Aizawa

    Journal of Cardiology47 ( 3 ) 143 - 146   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 74-year-old female developed aortocoronary dissection during percutaneous coronary intervention. The forceful manipulation of the guide catheter and contrast medium injection seemed to be the cause of the aortocoronary dissection involving the coronary sinus of Valsalva. The entry of the dissection was closed with subsequent obliteration of the false lumen by coronary stenting under the guidance of intracoronary ultrasonography and angiography.

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▶ 全件表示

MISC

  • 全脳室および後頭蓋窩拡大を呈した水頭症に対し第3脳室底開窓術を行った42歳男性例

    勇 亜衣子, 中村 航世, 太田 智慶, 柳村 文寛, 畠山 公大, 佐治 越爾, 佐野 正和, 河内 泉, 岡本 浩一郎, 小野寺 理

    神経治療学36 ( 6 ) S231 - S231   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本神経治療学会  

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  • 持続性部分てんかんで発症しfalse lateralizationを認めた抗GAD抗体陽性脳炎成人例

    坂田 佑輔, 佐治 越爾, 永井 貴大, 渡邉 緑, 柴田 健太郎, 他田 正義, 河内 泉, 小野寺 理

    てんかん研究37 ( 2 ) 679 - 679   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • MS/NMO1 多発性硬化症における認知機能障害と頭部MRIを用いたVBM解析

    若杉 尚宏, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 柳川 香織, 小野寺 理, 河内 泉

    神経免疫学24 ( 1 ) 106 - 106   2019年9月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • 多発性硬化症および視神経脊髄炎患者の臨床的特徴 過去28年間における変遷

    佐治 越爾, 中島 章博, 若杉 尚宏, 柳村 文寛, 柳川 香織, 穂苅 万李子, 小野寺 理, 河内 泉

    神経免疫学24 ( 1 ) 144 - 144   2019年9月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • 本邦における高齢発症視神経脊髄炎の臨床免疫学的特徴 連続73症例の解析から

    中島 章博, 佐治 越爾, 若杉 尚宏, 柳村 文寛, 柳川 香織, 穂苅 万李子, 小野寺 理, 河内 泉

    神経免疫学24 ( 1 ) 144 - 144   2019年9月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • Double inversion recovery MRI in the evaluation of the anterior visual pathway in patients with multiple sclerosis and neuromyelitis optica spectrum disorders

    E. Saji, M. Hokari, A. Yokoseki, T. Wakasugi, F. Yanagimura, K. Yanagawa, M. Nishizawa, O. Onodera, I. Kawachi

    MULTIPLE SCLEROSIS JOURNAL23   102 - 102   2017年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Dynamics of tissue regulatory T cells in neuromyelitis optica spectrum disorders lesions

    F. Yanagimura, E. Saji, T. Wakasugi, M. Hokari, Y. Toyoshima, A. Kakita, H. Takahashi, M. Nishizawa, O. Onodera, I. Kawachi

    MULTIPLE SCLEROSIS JOURNAL23   492 - 492   2017年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • 臨床ケース 再発性胸腺腫術後に腹壁の難治性疼痛を呈した重症筋無力症の44歳男性例

    山岸 拓磨, 佐治 越爾, 荻根沢 真也, 安藤 昭一郎, 茂木 崇秀, 他田 正義, 河内 泉, 小野寺 理

    神経免疫学22 ( 1 ) 106 - 106   2017年10月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • 臨床ケース 再発性胸腺腫術後に腹壁の難治性疼痛を呈した重症筋無力症の44歳男性例

    山岸 拓磨, 佐治 越爾, 荻根沢 真也, 安藤 昭一郎, 茂木 崇秀, 他田 正義, 河内 泉, 小野寺 理

    神経免疫学22 ( 1 ) 106 - 106   2017年10月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • 肥厚性硬膜炎・自己免疫疾患・膠原病 診断基準・重症度分類作成に向けた肥厚性硬膜炎の臨床的・免疫学的解析

    佐治 越爾, 横関 明子, 若杉 尚宏, 柳村 文寛, 穂苅 万李子, 柳川 香織, 西澤 正豊, 小野寺 理, 河内 泉

    神経免疫学22 ( 1 ) 89 - 89   2017年10月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • 単下肢失調を呈した多発性硬化症の30歳女性例

    井上 佳奈, 大原 浩司, 茂木 崇秀, 佐治 越爾, 他田 正義, 河内 泉, 下畑 享良, 小野寺 理

    臨床神経学57 ( 6 ) 335 - 335   2017年6月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • The 3rd MS Summer College in Kobe (6–7 August 2016)Practical issues and new horizons in MS, NMOSD and related disorders

    Etsuji Saji, Izumi Kawachi

    Clinical and Experimental Neuroimmunology8   58 - 62   2017年1月

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    記述言語:英語  

    DOI: 10.1111/cen3.12355

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 肥厚性硬膜炎の診断基準・重症度分類に関する研究

    河内泉, 西澤正豊, 佐治越爾, 横関明子, 柳村文寛, 若杉尚宏, 荒川武蔵, 柳川香織, 穂苅万李子, 小野寺理, 豊島靖子, 柿田明美, 高橋均

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 平成28年度 総括・分担研究報告書(Web)   50‐51 (WEB ONLY)   2017年

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    記述言語:日本語  

    J-GLOBAL

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  • 眼窩炎症性偽腫瘍における髄液サイトカイン・ケモカインの検討

    佐治 越爾, 西田 茉那, 柳村 文寛, 穂苅 万李子, 若杉 尚宏, 柳川 香織, 小野寺 理, 西澤 正豊, 河内 泉

    神経免疫学21 ( 1 ) 139 - 139   2016年9月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • Severe neurodegeneration and unique dynamics of aquaporin-4 on astrocytes in the anterior visual pathway of neuromyelitis optica.

    I. Kawachi, M. Hokari, A. Yokoseki, M. Arakawa, E. Saji, K. Yanagawa, F. Yanagimura, Y. Toyoshima, A. Kakita, H. Takahashi, O. Onodera, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL22   24 - 24   2016年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • 慢性腎臓病急性増悪時に突然の意識障害とびまん性の脳幹病変を呈した44歳女性例

    齋藤 奈つみ, 石黒 舞乃, 佐治 越爾, 下畑 享良, 小野寺 理, 羽深 将人, 細島 康宏, 山本 卓, 成田 一衛

    臨床神経学56 ( 9 ) 646 - 646   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • Neuromyelitis optica脳病変における神経放射線学的・神経病理学的特徴

    穂苅 万李子, 佐治 越爾, 柳村 文寛, 柳川 香織, 豊島 靖子, 柿田 明美, 高橋 均, 小野寺 理, 西澤 正豊, 河内 泉

    神経免疫学21 ( 1 ) 124 - 124   2016年9月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • 重症帯状疱疹のためフィンゴリモド一時中断に伴いbreakthrough disease様の進展を来した多発性硬化症の一例

    大津 裕, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 若杉 尚宏, 柳川 香織, 西澤 正豊, 河内 泉, 小野寺 理

    神経免疫学21 ( 1 ) 108 - 108   2016年9月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • 眼窩炎症性偽腫瘍における髄液サイトカイン・ケモカインの検討

    佐治 越爾, 西田 茉那, 柳村 文寛, 穂苅 万李子, 若杉 尚宏, 柳川 香織, 小野寺 理, 西澤 正豊, 河内 泉

    神経免疫学21 ( 1 ) 139 - 139   2016年9月

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    記述言語:日本語   出版者・発行元:日本神経免疫学会  

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  • Role of meningeal lymphoid follicle-like structures in the CNS inflammatory disorders

    Izumi Kawachi, Mariko Hokari, Etsuji Saji, Yasuko Toyoshima, Akiko Yokoseki, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizaw

    JOURNAL OF NEUROIMMUNOLOGY275 ( 1-2 ) 64 - 64   2014年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jneuroim.2014.08.169

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  • Clinical and radiological profiles of anterior visual pathway involvement in neuromyelitis optica

    I. Kawachi, A. Yokoseki, E. Saji, M. Hokari, K. Yanagawa, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL20   349 - 350   2014年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Clinical Profiles of Elderly Patients with ADEM in A Japanese Cohort

    Mariko Hokari, Etsuji Saji, Akiko Yokoseki, Musashi Arakawa, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL20 ( 7 ) 948 - 948   2014年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Neuromyelitis Optica with Severe Progressive Cognitive and Psychiatric Impairment: Pathological Analysis of Three Autopsied Cases

    Musashi Arakawa, Etsuji Saji, Yasuko Toyoshima, Mariko Hokari, Akiko Yokoseki, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL20 ( 7 ) 945 - 946   2014年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Optic Perineuritis-like Lesions in Neuromyelitis Optica: Radiological Assessments

    Akiko Yokoseki, Etsuji Saji, Musashi Arakawa, Mariko Hokari, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL20 ( 7 ) 940 - 940   2014年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Radiological and Pathological Analyses of Cortical Lesions in Inflammatory Demyelinating Diseases of the Central Nervous System

    Etsuji Saji, Musashi Arakawa, Akiko Yokoseki, Mariko Hokari, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL20 ( 7 ) 940 - 941   2014年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • CNS pathology in neuromyelitis optica: region-dependent dynamics of aquaporin-4

    M. Arakawa, E. Saji, Y. Toyoshima, M. Hokari, A. Yokoseki, A. Kakita, H. Takahashi, M. Nishizawa, I. Kawachi

    MULTIPLE SCLEROSIS JOURNAL19 ( 11 ) 330 - 331   2013年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Longitudinal flow cytometric profiles of immune cells in the cerebrospinal fluid and blood of patients with multiple sclerosis under fingolimod therapy

    I. Kawachi, A. Yokoseki, E. Saji, M. Arakawa, M. Hokari, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL19 ( 11 ) 459 - 459   2013年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Cortical degeneration in neuromyelitis optica: Potential pathogenesis of cognitive impairment

    Etsuji Saji, Masatoyo Nishizawa, Izumi Kawachi

    Clinical and Experimental Neuroimmunology4 ( 2 ) 162   2013年8月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1111/cen3.12041

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  • Characteristic features of inflammatory demyelination and neurodegeneration in neuromyelitis optica spectrum disorder

    Musashi Arakawa, Yasuko Toyoshima, Etsuji Saji, Kaori Yanagawa, Akiko Yokoseki, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    JOURNAL OF NEUROIMMUNOLOGY253 ( 1-2 ) 148 - 148   2012年12月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE BV  

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  • Potential role of CCR6+T cells in inflammatory demyelinating diseases of central nervous system

    Etsuji Saji, Musashi Arakawa, Mariko Hokari, Yasuko Toyosima, Kaori Yanagawa, Akiko Yokoseki, Akiyoshi Kakita, Hitsohi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    JOURNAL OF NEUROIMMUNOLOGY253 ( 1-2 ) 76 - 77   2012年12月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE BV  

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  • Diagnostic dilemma of Japanese patients with AQP4 antibody

    I. Kawachi, K. Yanagawa, E. Saji, M. Arakawa, A. Yokoseki, M. Hokari, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL18   71 - 72   2012年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Absence of meningeal lymphoid neogenesis in neuromyelitis optica

    I. Kawachi, K. Yanagawa, Y. Toyoshima, E. Saji, M. Arakawa, A. Yokoseki, A. Kakita, H. Takahashi, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL17   S292 - S292   2011年10月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

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  • Inflammatory Myopathy Associated with Primary Biliary Cirrhosis

    Mariko Hokari, Izumi Kawachi, Etsuji Saji, Kaori Yanagawa, Akio Yokoseki, Yasuko Toyoshima, Masatoyo Nishizawa

    NEUROLOGY76 ( 9 ) A105 - A105   2011年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • 多系統萎縮症とパーキンソン病に共通して見られる腸音発生頻度の低下

    小澤 鉄太郎, 佐治 越爾, 矢島 隆二, 小野寺 理, 西澤 正豊

    臨床神経学50 ( 12 ) 1261 - 1261   2010年12月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • Potential role of cellular immunity in neuromyleitis optica

    Kawachi Izumi, Toyoshima Yasuko, Yanagawa Kaori, Saji Etsuji, Kakita Akiyoshi, Takahashi Hitoshi, Nishizawa Masatoyo

    JOURNAL OF NEUROIMMUNOLOGY228 ( 1-2 ) 138 - +   2010年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE BV  

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  • Treatment responsive opsoclonus-ataxia associated with ovarian teratoma

    I. Kawachi, E. Saji, Y. Toyoshima, J. Dalmau, M. Nishizawa

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY81 ( 5 ) 581 - 582   2010年5月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:B M J PUBLISHING GROUP  

    DOI: 10.1136/jnnp.2009.177261

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  • Neuropsychiatric Presentation of Neuromyelitis Optica Spectrum Disorders

    Etsuji Saji, Yasuko Toyoshima, Kaori Yanagawa, Masatoyo Nishizawa, Izumi Kawachi

    NEUROLOGY74 ( 9 ) A169 - A169   2010年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Opsoclonus-ataxia syndrome(OAS)で発症した卵巣奇形腫関連傍腫瘍神経症候群の24歳女性例

    佐治 越爾, 河内 泉, 田中 惠子, 西澤 正豊

    神経治療学25 ( 3 ) 286 - 286   2008年5月

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    記述言語:日本語   出版者・発行元:(一社)日本神経治療学会  

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