Updated on 2026/06/24

写真a

 
HIRAISHI Tetsuya
 
Organization
University Medical and Dental Hospital Neurosurgery Lecturer
Title
Lecturer
External link

Degree

  • 博士（医学） ( 2011.3   新潟大学 )

Research Areas

  • Life Science / Neurosurgery

Research History (researchmap)

  • Brain Reseach Institute, Niigata University   Department of Neurosurgery   Assistant Professor

    2016.4

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    Country：Japan

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  • 新潟大学医歯学総合病院   脳神経外科   特任助教

    2015.7 - 2016.3

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    Country：Japan

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  • 新潟大学医歯学総合病院   脳神経外科   病院助教

    2014.4 - 2015.6

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    Country：Japan

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  • Saga University   Assistant Professor

    2010.4 - 2010.9

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    Country：Japan

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Research History

  • Niigata University   Neurosurgery, University Medical and Dental Hospital   Lecturer

    2023.9

  • Niigata University   Brain Research Institute Clinical Neuroscience Branch   Assistant Professor

    2016.4 - 2023.8

  • Niigata University   University Medical and Dental Hospital Neurosurgery   Specially Appointed Assistant Professor

    2015.7 - 2016.3

Education

  • Niigata University   分子医学専攻   脳神経外科

    2007.4 - 2011.3

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    Country： Japan

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  • 国立新潟大学   医学部医学科

    - 2002.3

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Papers

  • Early glucocorticoid therapy for brainstem edema associated with acute inflammatory Teflon granuloma after microvascular decompression for trigeminal neuralgia: illustrative case. International journal

    Kiichi Sakai, Ryosuke Ogura, Kouichirou Okamoto, Kaoru Tomikawa, Ryota Okura, Shisei Yoshida, Daiju Mitsuhashi, Tetsuya Hiraishi, Makoto Oishi

    Journal of neurosurgery. Case lessons   11 ( 11 )   2026.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Teflon (polytetrafluoroethylene) is widely used in microvascular decompression (MVD) for trigeminal neuralgia (TN) as an effective material to separate the offending vessel from the trigeminal nerve. Teflon granuloma develops in approximately 1.1%-7.3% of MVD cases and can lead to recurrent TN. However, acute inflammatory Teflon granuloma-characterized by an early inflammatory reaction extending to the brainstem and resulting in edema and neurological deficits-is rare, and optimal management strategies remain unclear. OBSERVATIONS: A 43-year-old man underwent MVD using two ball-shaped Teflon implants for vertebral artery transposition. Although his TN resolved immediately, he developed facial palsy and hearing disturbance on postoperative day 23. MRI showed marked FLAIR hyperintensity surrounding the Teflon adjacent to the brainstem without diffusion restriction, suggesting acute inflammation without evidence of infection. Prednisolone (20 mg/day) was initiated, leading to rapid improvement of neurological symptoms and resolution of the edema. Glucocorticoids were gradually tapered and discontinued over 6 months, and no recurrence was observed during a 2-year follow-up period. LESSONS: Although surgical removal is generally recommended for symptomatic Teflon granuloma, early glucocorticoid therapy may be effective when acute inflammatory Teflon granuloma is suspected and infection has been carefully excluded. https://thejns.org/doi/10.3171/CASE251023.

    DOI： 10.3171/CASE251023

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  • Preoperative interactive virtual simulation applying three-dimensional multifusion images using a haptic device for lumbosacral lipoma. International journal

    Ryosuke Ogura, Hidemoto Fujiwara, Manabu Natsumeda, Tetsuya Hiraishi, Masakazu Sano, Makoto Oishi

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery   40 ( 4 )   1129 - 1136   2024.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Untethering surgery for lumbosacral lipoma is a preventive procedure, and avoidance of complications and good long-term outcomes are required. We introduced presurgical interactive virtual simulation (IVS) applying three-dimensional multifusion images using a haptic device aimed at improving operative outcomes. METHODS: Fourteen patients with newly diagnosed lumbosacral lipoma were recruited and underwent preoperative IVS. The median age at surgery was 8 months. A three-dimensional image analysis system was used to extract and fuse structures necessary for surgery, such as the lipoma, spinal cord and skin, from CT and MRI, and create three-dimensional multifusion images. The created images were individually converted to standard triangulated language format and loaded onto a workstation (Geomagic freeform™) that could be freely transformed, and the laminectomy range and lipoma extraction procedure were examined. Presurgical IVS was performed, and the actual surgery was performed. RESULTS: The disease types were dorsal, caudal, lipomyelomeningocele, transitional, and filum in 5, 5, 2, 1, and 1 patients, respectively. The surgical procedure and extent of the laminectomy were as planned for all patients. Resection of the lipomas tended to be less than expected preoperatively because of positive reactions on intraoperative monitoring. No postoperative complications were observed. The median postoperative follow-up period was 29 months, and there were no reoperations during the observation period. CONCLUSIONS: Although there are various types of lumbosacral lipoma, surgery can be safely performed by performing presurgical IVS. The short-term course is good; however, long-term follow-up is necessary for the appearance of neurological symptoms associated with growth and re-tethering.

    DOI： 10.1007/s00381-023-06234-2

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  • 毛様細胞性星細胞腫(Non-NF1)の治療と現状

    大石 誠, 棗田 学, 塚本 佳広, 小倉 良介, 三橋 大樹, 平石 哲也

    小児の脳神経   49 ( 2 )   207 - 207   2024.4

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    Language：Japanese   Publisher：(一社)日本小児神経外科学会  

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  • 画像診断 小児神経外科手術における外視鏡と三次元融合画像の有用性

    小倉 良介, 吉田 至誠, 藤原 秀元, 棗田 学, 平石 哲也, 大石 誠

    小児の脳神経   49 ( 2 )   167 - 167   2024.4

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    Language：Japanese   Publisher：(一社)日本小児神経外科学会  

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  • Multi-omics analyses of choroid plexus carcinoma cell lines reveal potential targetable pathways and alterations. International journal

    Dina Hesham, Jotaro On, Nouran Alshahaby, Nada Amer, Sameh Magdeldin, Masayasu Okada, Yoshihiro Tsukamoto, Tetsuya Hiraishi, Chihaya Imai, Shujiro Okuda, Toshifumi Wakai, Akiyoshi Kakita, Makoto Oishi, Shahenda El-Naggar, Manabu Natsumeda

    Journal of neuro-oncology   166 ( 1 )   27 - 38   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Choroid plexus carcinomas (CPCs) are extremely rare brain tumors and carry a dismal prognosis. Treatment options are limited and there is an urgent need to develop models to further research. In the present study, we established two CPC cell lines and performed multi-omics analyses. These cell lines serve as valuable models to propose new treatments in these rare but deadly brain tumors. METHODS: Multi-omic profiling including, (i) methylation array (EPIC 850 K), (ii) whole genome sequencing (WGS), (iii) CANCERPLEX cancer genome panel testing, (iv) RNA sequencing (RNA-seq), and (v) proteomics analyses were performed in CCHE-45 and NGT131 cell lines. RESULTS: Both cell lines were classified as methylation class B. Both harbored pathogenic TP53 point mutations; CCHE-45 additionally displayed TP53 loss. Furthermore, alterations of the NOTCH and WNT pathways were also detected in both cell lines. Two protein-coding gene fusions, BZW2-URGCP, and CTTNBP2-ERBB4, mutations of two oncodrivers, GBP-4 and KRTAP-12-2, and several copy number alterations were observed in CCHE-45, but not NGT131. Transcriptome and proteome analysis identified shared and unique signatures, suggesting that variability in choroid plexus carcinoma tumors may exist. The discovered difference's importance and implications highlight the possible diversity of choroid plexus carcinoma and call for additional research to fully understand disease pathogenesis. CONCLUSION: Multi-omics analyses revealed that the two choroid plexus carcinoma cell lines shared TP53 mutations and other common pathway alterations and activation of NOTCH and WNT pathways. Noticeable differences were also observed. These cell lines can serve as valuable models to propose new treatments in these rare but deadly brain tumors.

    DOI： 10.1007/s11060-023-04484-3

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  • ACTH産生PitNETの集学的治療戦略と成績

    岡田 正康, 平石 哲也, 米岡 有一郎, 石黒 創, 北澤 勝, 曽根 博仁, 大石 誠

    日本内分泌学会雑誌   99 ( 4 )   896 - 896   2024.1

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    Language：Japanese   Publisher：(一社)日本内分泌学会  

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  • 嚢胞形成PRL産生PitNETの治療成績

    岡田 正康, 小倉 良介, 平石 哲也, 米岡 有一郎, 大石 誠

    新潟医学会雑誌   137 ( 12 )   447 - 447   2023.12

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    Language：Japanese   Publisher：新潟医学会  

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  • 聴神経腫瘍手術における定電流刺経頭蓋電気刺激顔面神経運動誘発電位の有用性

    平石 哲也, 三橋 大樹, 小倉 良介, 大石 誠

    臨床神経生理学   51 ( 5 )   614 - 614   2023.10

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    Language：Japanese   Publisher：(一社)日本臨床神経生理学会  

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  • 【「脳神経外科領域におけるPDTの現状と問題点」】当科における光線力学療法の経験および次世代への挑戦

    棗田 学, 温 城太郎, 渡邉 潤, 塚本 佳広, 岡田 正康, 小倉 良介, 平石 哲也, 大石 誠, 藤井 幸彦

    日本レーザー医学会誌   44 ( 2 )   95 - 101   2023.7

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  • 【「脳神経外科領域におけるPDTの現状と問題点」】当科における光線力学療法の経験および次世代への挑戦

    棗田 学, 温 城太郎, 渡邉 潤, 塚本 佳広, 岡田 正康, 小倉 良介, 平石 哲也, 大石 誠, 藤井 幸彦

    日本レーザー医学会誌   44 ( 2 )   95 - 101   2023.7

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  • 髄液よりH3K27M変異が検出可能なdiffuse midline gliomaの検討

    棗田 学, 温 城太郎, 渡邉 潤, 高橋 陽彦, 塚本 佳広, 岡田 正康, 平石 哲也, 吉村 淳一, 大石 誠, 藤井 幸彦

    小児の脳神経   47 ( 4 )   358 - 364   2022.11

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  • Visualization of cortical activation in human brain by flavoprotein fluorescence imaging. International journal

    Daiju Mitsuhashi, Ryuichi Hishida, Makoto Oishi, Tetsuya Hiraishi, Manabu Natsumeda, Katsuei Shibuki, Yukihiko Fujii

    Journal of neurosurgery   1 - 9   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: To develop an innovative brain mapping and neuromonitoring method during neurosurgery, the authors set out to establish intraoperative flavoprotein fluorescence imaging (iFFI) to directly visualize cortical activations in human brain. The significance of iFFI was analyzed by comparison with intraoperative perfusion-dependent imaging (iPDI), which is considered the conventional optical imaging, and by performing animal experiments. METHODS: Seven patients with intracerebral tumors were examined by iFFI and iPDI following craniotomy, using a single operative microscope equipped with a laser light source for iFFI and xenon lamp for iPDI. Images were captured by the same charge-coupled device camera. Responses to bipolar stimulation at selected points on the cortical surface were analyzed off-line, and relative signal changes were visualized by overlaying pseudocolor intensity maps onto cortical photographs. Signal changes exceeding 3 SDs from baseline were defined as significant. The authors also performed FFI and PDI on 10 mice using similar settings, and then compared signal patterns to intraoperative studies. RESULTS: Signals acquired by iFFI exhibited biphasic spatiotemporal changes consisting of an early positive signal peak (F1) and a delayed negative signal peak (F2). In contrast, iPDI signals exhibited only 1 negative peak (P1) that was significantly delayed compared to F1 (p < 0.02) and roughly in phase with F2. Compared to F2 and P1, F1 was of significantly lower amplitude (p < 0.02) and located closer to the bipolar stimulus center (p < 0.03), whereas F2 and P1 were more widespread, irregular, and partially overlapping. In mice, the spatiotemporal characteristics of FFI and PDI resembled those of iFFI and iPDI, but the early positive signal was more robust than F1. CONCLUSIONS: This is the first report in humans of successful intraoperative visualization of cortical activations by using iFFI, which showed rapid evoked cortical activity prior to perfusion-dependent signal changes. Further technical improvements can lead to establishment of iFFI as a real-time intraoperative tool.

    DOI： 10.3171/2022.1.JNS212542

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  • Meningoencephalocele in the Lateral Sphenoid Sinus Showing Malformation of Cortical Development: A Case Report.

    Taro Sato, Tetsuya Hiraishi, Mari Tada, Manabu Natsumeda, Jotaro On, Haruhiko Takahashi, Taiki Saito, Noritaka Okubo, Makoto Oishi, Akiyoshi Kakita, Yukihiko Fujii

    NMC case report journal   9   281 - 287   2022

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    Meningoencephalocele in the lateral sphenoid sinus (SS) has been determined to be a rare entity often detected by cerebrospinal fluid (CSF) rhinorrhea. To date, the pathology of meningoencephalocele in the lateral SS has remained to be unclear in many cases. In this study, we report on a case of a 72-year-old woman with an arteriovenous malformation who presented with CSF rhinorrhea. Radiologic investigations revealed a left temporal meningoencephalocele in the lateral SS. We removed the meningoencephalocele and performed skull base repair, after which the CSF rhinorrhea resolved. Pathological examination showed congenital cortical abnormalities with dysmorphic neurons in various shapes and acquired chronic tissue alterations including fibrillary gliosis and scattered Rosenthal fibers. These findings may further aid in understanding the etiopathogenesis of meningoencephalocele in the lateral SS.

    DOI： 10.2176/jns-nmc.2022-0152

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  • Endovascular treatment of an infectious aneurysm using the selective provocative test and transcranial motor evoked potential monitoring under general anesthesia: a case report. International journal

    Kazuhiro Ando, Tetsuya Hiraishi, Makoto Oishi, Hitoshi Hasegawa, Bumpei Kikuchi, Manabu Natsumeda, Tomoaki Suzuki, Shoji Saito, Tomoyoshi Ota, Yuichi Yoshida, Yukihiko Fujii

    Acta neurochirurgica   164 ( 5 )   1265 - 1269   2021.9

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    The selective provocative test (SPT) under local anesthesia aids in protecting against ischemic complications during endovascular treatment. However, the use of this test under general anesthesia is not well described. Herein, we present a case of a 51-year-old man with a ruptured fusiform aneurysm in the middle cerebral artery M4 segment, which was thought to possibly supply the motor cortex. Internal trapping of the affected vessel and aneurysm by endovascular intervention was successfully performed after SPT using transcranial motor evoked potential (MEP) monitoring under general anesthesia. Transcranial MEP is suitable for neurological assessment during SPT under general anesthesia.

    DOI： 10.1007/s00701-021-05001-z

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  • 脳神経外科領域におけるPDTの現状と問題点 当科における光線力学療法の経験および次世代への挑戦

    棗田 学, 塚本 佳広, 温 城太郎, 渡邉 潤, 江田 岳誉, 平石 哲也, 佐野 正和, 大石 誠, 藤井 幸彦

    日本レーザー医学会誌   42 ( 3 )   161 - 161   2021.9

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    Language：Japanese   Publisher：(NPO)日本レーザー医学会  

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  • Reactive astrocytes contribute to epileptogenesis in patients with cavernous angioma. International journal

    Hiroki Kitaura, Tetsuya Hiraishi, Yosuke Itoh, Makoto Oishi, Yukihiko Fujii, Masafumi Fukuda, Akiyoshi Kakita

    Epilepsy research   176   106732 - 106732   2021.7

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    OBJECTIVE: Patients with cavernous angioma (CA) often suffer from severe epilepsy, and surgical resection is often performed to attenuate these epileptic seizures. Several studies have suggested that surgical removal of the surrounding hemosiderin-pigmented tissues adjacent to CA achieves better seizure control than restricted lesionectomy. Pathological examination of the resected foci reveals not only hemosiderin pigmentation but also various degrees of inflammatory change, such as hemosiderin-laden macrophages, gliosis and fibrosis. However, there is some controversy regarding the epileptogenic potential of these regions due to the uncertain nature of the mechanisms contributing to these histopathological changes. METHODS: To investigate the correlations between neuron hyperexcitability and evident pathological changes, we performed ex vivo flavoprotein fluorescence imaging using surgically resected epileptogenic foci surrounding CA. The mirror surfaces of the tissues used for the physiological experiment were also subjected to morphological examination. RESULTS: Hemosiderin-laden macrophages and many gemistocytic astrocytes were observed in the area adjacent to CA, where horizontal spreading excitations were detected significantly more frequently. Outside these areas, we found fine granular iron deposits and only a few fibrillary astrocytes, and weakly propagating excitations were detected. Furthermore, areas of enhanced activation were more clearly correlated with the glial proliferation index than with iron deposition. CONCLUSION: These results suggest that the epileptogenesis in patients with CA may be based on a biological process, such as alteration of glial function, rather than direct chemical reactions involving iron deposition.

    DOI： 10.1016/j.eplepsyres.2021.106732

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  • Four-dimensional multifusion imaging for assessment of meningioma hemodynamics

    Ryosuke Ogura, Makoto Oishi, Tetsuya Hiraishi, Haruhiko Takahashi, Kohei Shibuya, Tomoaki Suzuki, Manabu Natsumeda, Kouichirou Okamoto, Yukihiko Fujii

    Interdisciplinary Neurosurgery   24   101118 - 101118   2021.6

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    DOI： 10.1016/j.inat.2021.101118

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  • GH産生下垂体腺腫に対するソマトスタチンアナログの効果とソマトスタチン受容体発現分類の検討

    岡田 正康, 米岡 有一郎, 大石 誠, 平石 哲也, 佐野 正和, 棗田 学, 柿田 明美, 藤井 幸彦

    Brain Tumor Pathology   38 ( Suppl. )   094 - 094   2021.5

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    Language：Japanese   Publisher：日本脳腫瘍病理学会  

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  • 髄膜腫摘出術の7年後に発生した局所浸潤性・再発性fibromatosisの一例

    温 城太郎, 清水 宏, 齋藤 理恵, 渋谷 航平, 棗田 学, 平石 哲也, 佐野 正和, 梅津 哉, 藤井 幸彦, 柿田 明美

    Brain Tumor Pathology   38 ( Suppl. )   121 - 121   2021.5

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    Language：Japanese   Publisher：日本脳腫瘍病理学会  

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  • Hydrocephalus associated with small clinoidal meningioma that resolved after tumor removal: A case report Reviewed

    Hidemoto Fujiwara, Toyotaka Aiba, Tom Watanabe, Tetsuya Hiraishi, Yukihiko Fujii

    Neurological Surgery   44 ( 12 )   1039 - 1044   2016.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Igaku-Shoin Ltd  

    DOI： 10.11477/mf.1436203424

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  • Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation Reviewed

    Keisuke Sato, Masafumi Fukuda, Yosuke Sato, Tetsuya Hiraishi, Tetsuro Takao, Yukihiko Fujii

    NEUROSCIENCE LETTERS   630   136 - 140   2016.9

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    DOI： 10.1016/j.neulet.2016.07.037

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  • Free-running EMG monitoring during microvascular decompression for hemifacial spasm Reviewed

    Masafumi Fukuda, Tetsuro Takao, Tetsuya Hiraishi, Yukihiko Fujii

    ACTA NEUROCHIRURGICA   157 ( 9 )   1505 - 1512   2015.9

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    DOI： 10.1007/s00701-015-2492-7

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  • Pharyngeal Motor Evoked Potential Monitoring During Skull Base Surgery Predicts Postoperative Recovery from Swallowing Dysfunction Reviewed

    Masafumi Fukuda, Tetsuro Takao, Tetsuya Hiraishi, Naoki Yajima, Akihiko Saito, Yukihiko Fujii

    WORLD NEUROSURGERY   84 ( 2 )   555 - 560   2015.8

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    DOI： 10.1016/j.wneu.2015.04.023

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  • Cortico-cortical activity between the primary and supplementary motor cortex: An intraoperative near-infrared spectroscopy study Reviewed

    Masafumi Fukuda, Tetsuro Takao, Tetsuya Hiraishi, Hiroshi Aoki, Ryosuke Ogura, Yosuke Sato, Yukihiko Fujii

    Surgical Neurology International   6 ( 1 )   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Medknow Publications  

    DOI： 10.4103/2152-7806.153872

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  • Drainage patterns of the superficial middle cerebral vein: Effects on perioperative managements of petroclival meningioma Reviewed

    Masafumi Fukuda, Akihiko Saito, Tetsuro Takao, Tetsuya Hiraishi, Naoki Yajima, Yukihiko Fujii

    Surgical Neurology International   6 ( 1 )   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Medknow Publications  

    DOI： 10.4103/2152-7806.162483

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  • Cortico-cortical activity between the primary and supplementary motor cortex: An intraoperative near-infrared spectroscopy study. Reviewed

    Fukuda M, Takao T, Hiraishi T, Aoki H, Ogura R, Sato Y, Fujii Y

    Surgical neurology international   6   44   2015

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  • Drainage patterns of the superficial middle cerebral vein: Effects on perioperative managements of petroclival meningioma. Reviewed

    Fukuda M, Saito A, Takao T, Hiraishi T, Yajima N, Fujii Y

    Surgical neurology international   6   130   2015

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  • Clinical Factors Predicting Outcomes After Surgical Resection for Sporadic Cerebellar Hemangioblastomas Reviewed

    Masafumi Fukuda, Tetsuro Takao, Tetsuya Hiraishi, Junichi Yoshimura, Naoki Yajima, Akihiko Saito, Yukihiko Fujii

    WORLD NEUROSURGERY   82 ( 5 )   815 - 821   2014.11

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    DOI： 10.1016/j.wneu.2014.06.018

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  • Posterior condylar canals and posterior condylar emissary veins-a microsurgical and CT anatomical study Comments Reviewed

    Michael Bruneau, Giannantonio Spena, Peter A. Winkler, Helmut Bertalanffy

    NEUROSURGICAL REVIEW   37 ( 1 )   125 - 126   2014.1

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  • Posterior condylar canals and posterior condylar emissary veins-a microsurgical and CT anatomical study Reviewed

    Ken Matsushima, Masatou Kawashima, Toshio Matsushima, Tetsuya Hiraishi, Tomoyuki Noguchi, Akio Kuraoka

    NEUROSURGICAL REVIEW   37 ( 1 )   115 - 125   2014.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10143-013-0493-7

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  • Importance of awareness of the rhomboid lip in microvascular decompression surgery for hemifacial spasm Clinical article Reviewed

    Yukiko Nakahara, Toshio Matsushima, Tetsuya Hiraishi, Tetsuro Takao, Takeshi Funaki, Jun Masuoka, Masatou Kawashima

    JOURNAL OF NEUROSURGERY   119 ( 4 )   1038 - 1042   2013.10

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    DOI： 10.3171/2013.4.JNS121546

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  • 3D Computer graphics simulation to obtain optimal surgical exposure during microvascular decompression of the glossopharyngeal nerve Reviewed

    Tetsuya Hiraishi, Toshio Matsushima, Masatou Kawashima, Yukiko Nakahara, Yuichi Takahashi, Hiroshi Ito, Makoto Oishi, Yukihiko Fujii

    Neurosurgical Review   36 ( 4 )   629 - 635   2013.10

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    DOI： 10.1007/s10143-013-0479-5

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  • Interactive presurgical simulation applying advanced 3D imaging and modeling techniques for skull base and deep tumors Clinical article Reviewed

    Makoto Oishi, Masafumi Fukuda, Naoki Yajima, Kenzo Yoshida, Machiko Takahashi, Tetsuya Hiraishi, Tetsuro Takao, Akihiko Saito, Yukihiko Fujii

    JOURNAL OF NEUROSURGERY   119 ( 1 )   94 - 105   2013.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3171/2013.3.JNS121109

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  • Significance of horizontal propagation of synchronized activities in human epileptic neocortex investigated by optical imaging and immunohistological study Reviewed

    Tetsuya Hiraishi, Hiroki Kitaura, Makoto Oishi, Masafumi Fukuda, Shigeki Kameyama, Hitoshi Takahashi, Akiyoshi Kakita, Yukihiko Fujii

    Epilepsy Research   104 ( 1-2 )   59 - 67   2013.3

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    DOI： 10.1016/j.eplepsyres.2012.09.014

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  • Intraoperative monitoring of motor evoked potentials during glioma removal Reviewed

    Masafumi Fukuda, Makoto Oishi, Tetsuro Takao, Tetsuya Hiraishi, Tsutomu Kobayashi, Hiroshi Aoki, Ryosuke Ogura, Akihiko Saito, Yukihiko Fujii

    Neurological Surgery   41 ( 3 )   219 - 227   2013.3

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  • Facial nerve dysfunction after drainage of cerebrospinal fluid during vestibular schwannoma surgery Reviewed

    Tetsuya Hiraishi, Masafumi Fukuda, Makoto Oishi, Yukihiko Fujii

    CLINICAL NEUROLOGY AND NEUROSURGERY   115 ( 1 )   102 - 105   2013.1

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    DOI： 10.1016/j.clineuro.2012.04.003

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  • Novel devices for intraoperative monitoring of glossopharyngeal and vagus nerves during skull base surgery. Reviewed

    Fukuda M, Takao T, Hiraishi T, Yajima N, Saito A, Fujii Y

    Surgical neurology international   4   97   2013

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  • Interactive virtual simulation using a 3D computer graphics model for microvascular decompression surgery Clinical article Reviewed

    Makoto Oishi, Masafumi Fukuda, Tetsuya Hiraishi, Naoki Yajima, Yosuke Sato, Yukihiko Fujii

    JOURNAL OF NEUROSURGERY   117 ( 3 )   555 - 565   2012.9

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    DOI： 10.3171/2012.5.JNS112334

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  • Periventricular nodular heterotopia functionally couples with the overlying hippocampus Reviewed

    Hiroki Kitaura, Makoto Oishi, Nobuyuki Takei, Yong-Juan Fu, Tetsuya Hiraishi, Masafumi Fukuda, Hitoshi Takahashi, Katsuei Shibuki, Yukihiko Fujii, Akiyoshi Kakita

    EPILEPSIA   53 ( 7 )   e127 - e131   2012.7

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    DOI： 10.1111/j.1528-1167.2012.03509.x

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  • Periventricular nodular heterotopia functionally couples with the overlying hippocampus.

    Kitaura Hiroki, Oishi Makoto, Takei Nobuyuki, Fu Yong-Juan, Hiraishi Tetsuya, Fukuda Masafumi, Takahashi Hitoshi, Shibuki Katsuei, Fujii Yukihiko, Kakita Akiyoshi

    Epilepsia   53 ( 7 )   e127 - e131   2012.7

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    Patients with periventricular nodular heterotopia (PVNH) often have severe epilepsy. However, it is unclear how the heterotopia contributes to epileptogenesis. Recently, electrophysiologic studies using intraoperative depth electrodes have indicated that interaction between the heterotopia and overlying cortex is crucial for seizure onset. We performed an in vitro physiologic study using slices of resected brain from a 22-year-old man with PVNH, who manifested medically refractory mesial temporal lobe epilepsy. Preoperative evaluation indicated that the right mesial temporal structure and PVNH were the epileptogenic focus. The resected tissue was immediately immersed in cold artificial cerebrospinal fluid, and then slices of the brain tissue including the heterotopic nodules and overlying hippocampus were prepared. We electrically stimulated the incubated slices, and the elicited neural activities were analyzed as changes in the flavoprotein fluorescence signals. When we stimulated either the heterotopic nodule or the overlying hippocampus, clear functional coupling of neural activities between these structures was observed. The coupling response evoked by stimulation of the subi

    DOI： 10.1111/j.1528-1167.2012.03509.x

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  • Epidermoid cyst involving the medial temporal lobe: Surgical pathologic features of the epileptogenic lesion Reviewed

    Tetsuya Hiraishi, Makoto Oishi, Hiroki Kitaura, Masae Ryufuku, Yong-Juan Fu, Masafumi Fukuda, Hitoshi Takahashi, Yukihiko Fujii, Akiyoshi Kakita

    NEUROPATHOLOGY   32 ( 2 )   196 - 201   2012.4

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    DOI： 10.1111/j.1440-1789.2011.01243.x

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  • Pharyngeal motor evoked potentials elicited by transcranial electrical stimulation for intraoperative monitoring during skull base surgery Reviewed

    Masafumi Fukuda, Makoto Oishi, Tetsuya Hiraishi, Akihiko Saito, Yukihiko Fujii

    JOURNAL OF NEUROSURGERY   116 ( 3 )   605 - 610   2012.3

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    DOI： 10.3171/2011.10.JNS111343

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  • Monitoring of abnormal muscle response and facial motor evoked potential during microvascular decompression for hemifacial spasm. Reviewed International journal

    Fukuda M, Oishi M, Takao T, Hiraishi T, Sato Y, Fujii Y

    Surgical neurology international   3   118 - 118   2012

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    BACKGROUND: To determine whether the monitoring of abnormal muscle response (AMR) and facial motor evoked potential (FMEP) during microvascular decompression (MVD) for hemifacial spasm (HFS) might be useful for predicting the postoperative clinical course and final outcomes. METHODS: We analyzed 45 HFS patients who underwent both AMR and FMEP monitoring during MVD. Patients were divided into two groups on the basis of post-MVD disappearance (group AMR-A) or persistence (group AMR-B) of AMR. With regard to FMEPs, patients were classified into one of the two groups according to the ratio of the final to baseline FMEP amplitudes recorded for the orbicularis oculi muscle: one group with a ratio of <50% (group FMEP-A), and the other with a ratio of ≥50% (group FMEP-B). RESULTS: Twenty-one of the 26 (81%) patients in group AMR-A were assigned to group FMEP-A, whereas 9 of the 17 (53%) patients in group AMR-B were assigned to FMEP-B (P < 0.05). In 38 of the 40 (95%) patients in whom the AMRs disappeared or persisted at amplitudes <50% that at the baseline, HFS had subsided at the final follow-up. Forty of the 42 (95%) patients whose FMEP amplitude ratios indicated reduction in the amplitudes from the baseline, had complete relief of the symptoms. Nineteen of the 20 (95%) patients whose AMRs disappeared after MVD experienced immediate relief of their symptoms after the operation. With regard to 14 of the 20 (70%) patients whose AMRs persisted at the final recordings, the symptoms of HFS improved over time and eventually subsided (P < 0.001). CONCLUSIONS: Intraoperative monitoring of both AMR and FMEP during MVD may be useful in predicting the postoperative outcomes in HFS patients. The AMR-related findings may help to predict whether HFS disappears immediately after surgery or some time later.

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  • Spatiotemporal dynamics of epileptiform propagations: imaging of human brain slices.

    Kitaura Hiroki, Hiraishi Tetsuya, Murakami Hiroatsu, Masuda Hiroshi, Fukuda Masafumi, Oishi Makoto, Ryufuku Masae, Fu Yong-Juan, Takahashi Hitoshi, Kameyama Shigeki, Fujii Yukihiko, Shibuki Katsuei, Kakita Akiyoshi

    Neuroimage   58 ( 1 )   50 - 59   2011.9

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    Seizure activities often originate from a localized region of the cerebral cortex and spread across large areas of the brain. The properties of these spreading abnormal discharges may account for clinical phenotypes in epilepsy patients, although the manner of their propagation and the underlying mechanisms are not well understood. In the present study we performed flavoprotein fluorescence imaging of cortical brain slices surgically resected from patients with partial epilepsy caused by various symptomatic lesions. Elicited neural activities in the epileptogenic tissue spread horizontally over the cortex momentarily, but those in control tissue taken from patients with brain tumors who had no history of epilepsy demonstrated only localized responses. Characteristically, the epileptiform propagation comprised early and late phases. When the stimulus intensity was changed gradually, the early phase showed an all-or-none behavior, whereas the late phase showed a gradual increase in the response. Moreover, the two phases were propagated through different cortical layers, suggesting that they are derived from distinct neural circuits. Morphological investigation revealed the presence

    DOI： 10.1016/j.neuroimage.2011.05.046

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  • Spatiotemporal dynamics of epileptiform propagations: Imaging of human brain slices Reviewed

    Hiroki Kitaura, Tetsuya Hiraishi, Hiroatsu Murakami, Hiroshi Masuda, Masafumi Fukuda, Makoto Oishi, Masae Ryufuku, Yong-Juan Fu, Hitoshi Takahashi, Shigeki Kameyama, Yukihiko Fujii, Katsuei Shibuki, Akiyoshi Kakita

    NEUROIMAGE   58 ( 1 )   50 - 59   2011.9

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    DOI： 10.1016/j.neuroimage.2011.05.046

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  • Intraoperative facial nerve motor evoked potential monitoring during skull base surgery predicts long-term facial nerve function outcomes Reviewed

    Masafumi Fukuda, Makoto Oishi, Tetsuya Hiraishi, Akihiko Saito, Yukihiko Fujii

    NEUROLOGICAL RESEARCH   33 ( 6 )   578 - 582   2011.7

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    DOI： 10.1179/016164110X12700393823697

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  • Clinicopathological factors related to regrowth of vestibular schwannoma after incomplete resection Reviewed

    Masafumi Fukuda, Makoto Oishi, Tetsuya Hiraishi, Manabu Natsumeda, Yukihiko Fujii

    JOURNAL OF NEUROSURGERY   114 ( 5 )   1224 - 1231   2011.5

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    DOI： 10.3171/2010.11.JNS101041

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  • Usefulness of motor-evoked potential monitoring during coil embolization of anterior choroidal artery aneurysms: technical reports Reviewed

    Tetsuya Hiraishi, Masafumi Fukuda, Makoto Oishi, Kazuhiko Nishino, Junsuke Shinbo, Takatoshi Sorimachi, Yasushi Ito, Yukihiko Fujii

    NEUROLOGICAL RESEARCH   33 ( 4 )   360 - 362   2011.5

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    DOI： 10.1179/016164110X12807570

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  • Prediction of the Microsurgical Window for Skull-Base Tumors by Advanced Three-Dimensional Multi-fusion Volumetric Imaging Reviewed

    Makoto Oishi, Masafumi Fukuda, Go Ishida, Akihiko Saito, Tetsuya Hiraishi, Yukihiko Fujii

    NEUROLOGIA MEDICO-CHIRURGICA   51 ( 3 )   201 - 207   2011.3

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    DOI： 10.2176/nmc.51.201

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  • Presurgical Simulation With Advanced 3-Dimensional Multifusion Volumetric Imaging in Patients With Skull Base Tumors Reviewed

    Makoto Oishi, Masafumi Fukuda, Go Ishida, Akihiko Saito, Tetsuya Hiraishi, Yukihiko Fujii

    NEUROSURGERY   68 ( 1 Suppl Operative )   188 - 99; discussion 199   2011.3

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    DOI： 10.1227/NEU.0b013e318207b3ad

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  • Presurgical Simulation With Advanced 3-Dimensional Multifusion Volumetric Imaging in Patients With Skull Base Tumors Reviewed

    Makoto Oishi, Masafumi Fukuda, Go Ishida, Akihiko Saito, Tetsuya Hiraishi, Yukihiko Fujii

    NEUROSURGERY   68 ( 3 )   188 - 199   2011.3

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    DOI： 10.1227/NEU.0b013e318207b3ad

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  • Trigeminal Neuralgia Associated with the Specific Bridging Pattern of Transverse Pontine Vein: Diagnostic Value of Three-Dimensional Multifusion Volumetric Imaging Reviewed

    Makoto Oishi, Masafumi Fukuda, Yoshiyuki Noto, Tadashi Kawaguchi, Tetsuya Hiraishi, Yukihiko Fujii

    STEREOTACTIC AND FUNCTIONAL NEUROSURGERY   89 ( 4 )   226 - 233   2011

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    DOI： 10.1159/000326778

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  • Effects of abnormal muscle response monitoring on manipulation of microvascular decompression Reviewed

    Masafumi Fukuda, Makoto Oishi, Tetsuya Hiraishi, Yukihiko Fujii

    Neurological Surgery   38 ( 6 )   531 - 538   2010.6

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  • Facial nerve motor-evoked potential monitoring during microvascular decompression for hemifacial spasm Reviewed

    Masafumi Fukuda, Makoto Oishi, Tetsuya Hiraishi, Yukihiko Fujii

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   81 ( 5 )   519 - 523   2010.5

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    DOI： 10.1136/jnnp.2009.181495

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  • Unstable Stenosis of the Internal Carotid Artery Caused by a Craniofacial Nail-Gun Injury-Case Report Reviewed

    Tetsuya Hiraishi, Tadashi Kawaguchi, Tsutomu Kobayashi, Masaru Tomikawa, Yasushi Ito, Yukihiko Fujii

    NEUROLOGIA MEDICO-CHIRURGICA   49 ( 12 )   590 - 593   2009.12

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    DOI： 10.2176/nmc.49.590

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  • Presurgical Evaluaton for Lateral Suboccipital Craniotomy Using Contrast-enhanced CT Volumetric Imaging Reviewed

    Makoto Oishi, Masafumi Fukuda, Akihiko Saito, Tetsuya Hiraishi, Yukihiko Fujii

    NEUROLOGICAL SURGERY   37 ( 5 )   459 - 465   2009.5

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  • A Case of Bilateral Common Carotid Artery Dissections due to Localized Dissection of the Aortic Arch Reviewed

    Tetsuya Hiraishi, Hiroshi Motoyama, Hiroshi Abe

    NEUROLOGICAL SURGERY   37 ( 4 )   387 - 391   2009.4

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  • Delayed brain abscess after penetrating transorbital injury Reviewed

    Tetsuya Hiraishi, Masaru Tomikawa, Tsutomu Kobayashi, Tadashi Kawaguchi

    NEUROLOGICAL SURGERY   35 ( 5 )   481 - 486   2007.5

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Research Projects

  • Development of novel therapies for rare malignant brain tumors by drug screening using proprietary tumor cell lines

    Grant number：22K09251

    2022.4 - 2025.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • Identification of targeted gene mutations for precision based medicine in malignant meningioma

    Grant number：18K08990

    2018.4 - 2021.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    HIRAISHI TETSUYA

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    We designed this study based on the hypothesis that a gene panel could be used to identify driver mutations of unique to malignant meningiomas. Tumor cell culture lines for meningioma were relatively culturable if continuous passage was not expected. However, it was difficult to establish a continuously passaged strain that could be used for stable therapeutic experiments. In some cases, we attempted to conduct therapeutic experiments by introducing the TERT gene, but were unable to establish cell lines using this method. As a result, tumor cell lines were established in malignant meningiomas and rare malignant brain tumors. However, no driver gene abnormalities common to malignant meningiomas were identified.

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  • Development of a preoperative highly accurate evaluation method to detect epileptic foci -Analyzing high frequency oscillations with dense array EEG-

    Grant number：15K19955

    2015.4 - 2018.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    HIRAISHI TETSUYA, FUKUDA MASAFUMI, OISHI MAKOTO, TAKAO TETSUROU, KAKITA AKIYOSHI

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    Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

    Epileptic focus identification based on new approach is necessary to the spread of epilepsy surgery. Dense array EEG, which is constructed to include electrode coverage over the face and neck, the purpose of which is to feasibly electrographically sample basal brain regions, is a method of recording electroencephalography (EEG) with many more electrodes (up to 256) . High frequency oscillations (HFO) near epileptic discharges from patients with intractable epilepsy were detected by the dense array EEG. Dense array EEG is helpful to understanding epileptic focus with analyzing HFO.

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  • Development of novel therapy based on functional reorganization in brain tumor patients

    Grant number：25462247

    2013.4 - 2017.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Fujii Yukihiko, MATSUZAWA Hitoshi, HIRAISHI Tetsuya, AOKI Hiroshi, KURABE Satoshi, TSUKAMOTO Yoshihiro

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    Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）

    Motor functions in brain tumor patients were assessed by fMRI. The locus of primary sensory motor activation during contralesional hand grasp was displaced by the tumor, suggesting functional compromise and/or reorganization in the central sulcus region. Their contralesional cerebellum activation during contralesional hand grasp was also increased as compared to normal subjects, representing the first evidence that the cerebellum is involved in the functional reorganization in brain tumor patients.
    Intraoperative language functions were studied using NIRS. Cortical stimulation of Broca’s area elicits hemodynamic responses of NIRS in Wernicke’s area via cortico-cortical connectivity, demonstrating visualization of cortico-cortical evoked responses in language systems.
    These results can contribute to understand the mechanism for functional reorganization in brain tumor patients and provide important information on developing new therapy for brain tumors based on reorganization.

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  • The library of neurosurgical anatomy based on interactive virtual simulation using three dimensional multifusion volumetric imaging.

    Grant number：25462209

    2013.4 - 2016.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Takao Tetsuro, OISHI Makoto, HIRAISHI Tetsuya, FUKUDA Masafumi

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    We accumulate more three dimentional (3D) data results on a lot of preoperative simulation of micro neurosurgery, and they are available to use. The 3D data are multifusion volumetric imaging of skull base meningioma, vestibuler schwannnoma, hemifacial spasm and so on.
    Not only for trainee, the data can be used for preoperative simulation of rare cases by expert neurosurgeon. The data also can be used for anatomical research for each disease. In the anatomical seminar and cadaveric dissection, the step wise plaster figures made from the three dimensional multifusion volumetric imaging was useful to check the anatomical structure and progression of cadaveric dissection.

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  • Novel intraoperative monitoring using near- infrared spectroscopy-visualization of cortico-cortical network system

    Grant number：25462246

    2013.4 - 2016.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Fukuda Masafumi, AOKI Hiroshi, TAKAO Tetsuro, HIRAISHI Tetsuya, SATO Keisuke, SATO Yosuke

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    We developed novel probes of near-infrared spectroscopy (NIRS) to measure regional cerebral blood flow (rCBF) from brain surfaces. In a patient with brain tumor, stimulation to the supplementary motor area, where the seizure onset zone existed, lead to increase in rCBF in the primary motor area by intraoperative NIRS. In the other patients with brain tumor, stimulation to the inferior frontal gyrus in the left side resulted in increase in rCBF in the superior temporal gyrus. These results suggest that intraoperative NIRS could visualize cortico-cortical network system. In future, intraoperative NIRS likely evaluates the language system as intraopeartive monitoring.

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  • Investigation for early epileptogenetic features of human cortical tissues

    Grant number：24592116

    2012.4 - 2015.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    OISHI Makoto, HIRAISHI Tetsuya, KITAURA Hiroki

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    Grant amount：\5460000 （ Direct Cost: \4200000 、 Indirect Cost：\1260000 ）

    To characterize the physiological condition of human epileptic neocortex, we employed flavoprotein fluorescence imaging (FFI) and immunohistologically studied human cortical specimens. We found that correlations between specific FFI findings and decreases in parvalbumin positive neurons may represent an imbalance between excitatory and inhibitory systems in the epileptic neocortex.We believed that the characteristics of human cortical tissues in the early epileptogenetic stage have been visualized by this study.

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