2024/10/12 更新

写真a

フジハラ カズヤ
藤原 和哉
FUJIHARA Kazuya
所属
医歯学総合研究科 特任准教授
職名
特任准教授
外部リンク

学位

  • 博士(医学) ( 2014年11月   筑波大学 )

研究キーワード

  • 肥満学

  • 脂質異常症

  • 人工知能(AI)

  • 臨床疫学

  • 内分泌学

  • 糖尿病学

  • 内科学

  • 動脈硬化

  • 医療ビッグデータ

  • 生活習慣病

  • メタボリックシンドローム

  • 予防医学

  • 健康科学

研究分野

  • ライフサイエンス / 内科学一般

  • ライフサイエンス / 代謝、内分泌学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

  • ライフサイエンス / 栄養学、健康科学

  • ライフサイエンス / ゲノム生物学

経歴(researchmap)

  • 新潟大学   Graduate School of Medical and Dental Sciences

    2015年10月 - 現在

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  • 筑波大学   University Hospital

    2015年4月 - 2015年9月

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  • 筑波大学   University Hospital

    2010年4月 - 2015年3月

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  • 筑波大学附属病院 内分泌代謝・糖尿病内科 医員

    2009年4月 - 2010年3月

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  • 筑波大学   University Hospital

    2007年4月 - 2008年3月

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  • 麻生飯塚病院 医師

    2005年4月 - 2007年3月

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▶ 全件表示

経歴

  • 新潟大学   医歯学総合研究科   特任准教授

    2015年10月 - 現在

学歴

  • 筑波大学   Graduate School of Comprehensive Human Sciences

    2011年4月 - 2014年11月

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  • 筑波大学 医学専門学群

    1999年4月 - 2005年3月

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所属学協会

委員歴

  • 日本糖尿病・生活習慣病ヒューマンデータ学会   評議員  

    2020年4月 - 現在   

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  • 日本内分泌学会   評議員  

    2018年4月 - 現在   

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    団体区分:学協会

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  • 新潟市糖尿病対策推進会議   幹事  

    2017年10月 - 現在   

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    団体区分:学協会

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  • 日本疫学会 代議員  

    2017年6月 - 現在   

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    団体区分:学協会

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  • 日本動脈硬化学会 評議員  

    2016年7月 - 現在   

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    団体区分:学協会

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論文

  • 1259-P: Relationship between Number of Multiple Risk Factors and Functional Disability (FD) in Those With and Without Diabetes Mellitus (DM)

    HARUKA SHIOZAKI, KAZUYA FUJIHARA, KAHORI TSURUOKA, IZUMI IKEDA, MASARU KITAZAWA, YASUHIRO MATSUBAYASHI, MASAHIKO YAMAMOTO, TAKAHO YAMADA, SATORU KODAMA, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Although control of multiple risk factors is essential to prevent FD with and without DM, longitudinal studies are scarce that directly and quantitatively compare effects of such control. Thus, we assessed whether reaching multifactorial targets for HbA1c, blood pressure, non-HDLC, and lifestyle risks such as smoking and no physical activity are associated with FD in those with and without DM.

    Enrolled were 9652 Japanese aged 39-98 y. FD was defined based on the Japanese long-term care insurance system, and targets were based on ADA and Japanese guidelines.

    Of 8,861 non-DM persons, 6.3, 25.2 and 49.1% were on target for 0-2, 3 and 4 factors, respectively. Of 791 persons with DM, 12.4, 68.0 and 19.3% were on target for 0-2, 3-4 and 5 factors, respectively.

    Multivariate Cox analysis showed increased FD with decreased targets reached regardless of DM (Table, upper). Compared with people with non-DM who achieved 4 targets, non-DM persons who achieved 0 to 2 targets and DM persons who achieved 3 to 4 targets had nearly twice the incidence of FD (Table, lower). Moreover, people with DM who achieved only 0 to 2 targets had an approximately 4 times higher incidence of FD (Table, lower). Control of modifiable risk factors was effective regardless of DM. Achievement of all 5 targets among people with DM may reduce FD to the same level as in non-DM persons who achieved all 4 targets.

    <p></p> Disclosure

    H. Shiozaki: None. K. Fujihara: None. K. Tsuruoka: None. I. Ikeda: None. M. Kitazawa: None. Y. Matsubayashi: None. M. Yamamoto: None. T. Yamada: None. S. Kodama: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    Funding

    the Japan Society for the Promotion of Science (21K11569); Daiwa Securities Health Foundation

    DOI: 10.2337/db24-1259-p

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  • 1666-P: Effect of Obesity in Family History (FH) on the Prevalence of Type 2 Diabetes Mellitus (T2DM), Hypertension (HT), and Dyslipidemia (DL)

    IZUMI IKEDA, KAZUYA FUJIHARA, YASUNAGA TAKEDA, CHIKA HORIKAWA, SATORU KODAMA, EFREM D. FERREIRA, YASUMICHI MORI, TAKASHI KADOWAKI, RITSUKO YAMAMOTO-HONDA, YASUJI ARASE, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Heritability and obesity are strongly associated with the prevalence of T2DM, HT, and DL. We compared the effects of an FH of T2DM, HT, and DL combined with obesity on the prevalence of each in the same population. Of 41931 participants who underwent health checkups, the effects of an FH and BMI on the prevalence of those conditions were analyzed cross-sectionally. Prevalences of T2DM, HT, and DL were 5%, 20%, and 48%, respectively. Logistic regression analysis showed that ORs increased for all three as the number of FH positive cases increased and was most pronounced for T2DM. An FH of obesity and increased BMI were additively associated with the prevalence of the three diseases compared to BMI 20.0-21.9 and no positive FH (Fig. A). In addition, the combination of the number of family members with FH positivity (0,1, 2, ≥3) and obesity was additively associated with an increased FH of the three diseases compared to non-obesity and no FH of any of these diseases (Fig. B). For T2DM, the OR increased sharply in non-obese participants when the number of those with an FH of T2DM was ≥3 (14.4 [8.88-23.5]), but in obese participants the OR increased sharply when the number of those with an FH of T2DM was 2 (12.2 [8.85-16.9]) (Fig. B). Results suggest that, especially for T2DM, avoidance of obesity may be effective in reducing the prevalence of these disorders in those with many FH-positive family members.

    <p></p> Disclosure

    I. Ikeda: None. K. Fujihara: None. Y. Takeda: None. C. Horikawa: None. S. Kodama: None. E.D. Ferreira: None. Y. Mori: None. T. Kadowaki: None. R. Yamamoto-Honda: None. Y. Arase: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    DOI: 10.2337/db24-1666-p

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  • 1148-P: Trajectories of Abnormalities in Metabolic Parameters in Japanese Adolescents and Young Adults

    IZUMI IKEDA, KAZUYA FUJIHARA, HARUKA SHIOZAKI, SAKIKO Y. MORIKAWA, CHIKA HORIKAWA, YASUNAGA TAKEDA, HAJIME ISHIGURO, TAKAHO YAMADA, SATORU KODAMA, YOHEI OGAWA, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Childhood obesity mostly transitions into adulthood and leads to non-communicable diseases such as type 2 diabetes and metabolic syndrome. We aimed to examine individual-level transitions in metabolic parameters during adolescence and young adulthood. We analyzed metabolic parameters in 523 participants (311 males) who underwent health examinations at the ages of 14 y (8th grade) and 20 y. Weight status was assessed by the International Obesity Task Force at 14 y and by BMI (thinness: &amp;lt;18.5; normal: 18.5-24.9; obesity: ≥25.0) at 20 y. HbA1c ≥5.7% was defined as high. Clustered metabolic risk score (CMR) was calculated by summing the sex-age specific Z-scores of each metabolic factor (mean arterial pressure, non-HDLC, and HbA1c) with ≥1 SD defined as high. Among participants who were obese at 14 y, 56% of males and 29% of females remained obese at 20 y. In both sexes, 30-50% had high HbA1c and 30-50% had high CMR as tracked from adolescence to adulthood (table). Furthermore, the high CMR of obese females increased markedly from about 20% at 14 y to 50% at 20 y. In addition, 60% of females who were obese at both 14 y and 20 y had high HbA1c at 20 y. Results suggested the importance of lifestyle interventions from childhood, as about half of the high metabolic parameters observed in adolescents were tracked into adulthood, and obesity complications, which were rarely shown at 14 y, appeared in many at age 20 y.

    <p></p> Disclosure

    I. Ikeda: None. K. Fujihara: None. H. Shiozaki: None. S.Y. Morikawa: None. C. Horikawa: None. Y. Takeda: None. H. Ishiguro: None. T. Yamada: None. S. Kodama: None. Y. Ogawa: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    DOI: 10.2337/db24-1148-p

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  • 1264-P: Impacts of Diabetes (DM) on Severe Functional Disability (FD) and Care-Need Level Deterioration in Japanese

    IZUMI IKEDA, KAZUYA FUJIHARA, HARUKA SHIOZAKI, SAKIKO Y. MORIKAWA, KAHORI TSURUOKA, YAMASHITA YUKO, LAY MON KHIN, SIJIA WU, NORIKO YAGYUDA, CHIKA HORIKAWA, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Avoidance of FD and the deterioration of care level needs leading to a decline in ADL and increased medical costs is urgent. We aimed to clarify the association between lifestyle habits, non-communicable diseases (i.e., DM, HT, and dyslipidemia) and their combinations and the incidence of severe FD and deterioration of the care-level. Followed for a median of 3.7 years were 9673 people who underwent health checkups. Care-level ≥2 (total assistance needed) indicates severe FD and worsening from the initial examination indicates deterioration. During the study period, 111 cases of severe FD occurred. Multivariate analysis showed that aging (per 5y) (OR 2.24 [1.95-2.56]), male (1.76 [1.16-2.66]), BMI&amp;lt;18.5 (2.46 [1.40-4.35]), DM (1.81 [1.06-3.08]), HT (1.58 [1.05-2.38]), and lack of physical activity (PA) (2.17 [1.37-3.45]) were associated with severe FD. Prevalence of DM additively associated with severe FD. DM and ≥2 risk factors had a 10 times greater association than non-DM and no risk factor. Of 85 cases with worsening care needs, only DM was significantly associated with deterioration (2.88 [1.08-7.65]). DM is a significant risk factor for with double the increased risk of severe FD and triple care-need deterioration compared with those without DM. Also, in DM patients, low BMI, HT, and lack of PA greatly increased the risk of severe FD, suggesting the need for comprehensive treatment strategies.

    <p></p> Disclosure

    I. Ikeda: None. K. Fujihara: None. H. Shiozaki: None. S.Y. Morikawa: None. K. Tsuruoka: None. Y. Yuko: None. L. Khin: None. S. Wu: None. N. Yagyuda: None. C. Horikawa: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    DOI: 10.2337/db24-1264-p

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  • 1372-P: Association between Fat Intake as the Percent of Total Energy and Incidence of Cardiovascular Disease in Persons with Type 2 Diabetes—Japan Diabetes Complication and Its Prevention Prospective Study (JDCP Study)

    CHIKA HORIKAWA, MITSUYOSHI TAKAHARA, NAOTO KATAKAMI, YASUNAGA TAKEDA, MIZUKI TAKEUCHI, KAZUYA FUJIHARA, HIROAKI SUZUKI, NARIHITO YOSHIOKA, HITOSHI SHIMANO, JO SATOH, YASUAKI HAYASHINO, NAOKO TAJIMA, RIMEI NISHIMURA, YOSHIMITSU YAMASAKI, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Previous systematic reviews showed benefits of low-carbohydrate eating plans compared with low-fat eating plans in the treatment of diabetes (T2D) on parameters of cardiovascular disease (CVD) risk. However, studies on the relationship between fat intake as the % of total energy (F%E) and incidence of CVD in persons with T2D are insufficient. Therefore, we investigated this relationship as part of the JDCP study, a nationwide study launched in 2007. A total of 1477 persons with T2D aged 40-75 years completed a brief self-administered Diet History Questionnaire at baseline, and we analyzed the resultant data. Primary outcome was the 7-year risk of a CVD event. Hazard ratios for CVD according to quartiles of F%E (Q1-4) were estimated by Cox regression adjusted for confounders including sex, age, various laboratory tests, medication use, smoking history, drinking habits, physical activity, energy intake, protein intake, dietary fiber intake, and sodium intake. Mean F%E in Q1 to Q4 were 16.6%E, 21.8%E, 25.4%E, and 30.9%E, respectively. HbA1c, body mass index, triglycerides, and blood pressure were well controlled. No significant associations between F%E and incidence of CVD were shown for Q2, Q3, and Q4 relative to Q1 (Q2: 1.03 [95% CI, 0.47-2.28], Q3: 1.27 [0.58-2.76], and Q4: 1.10 [0.44-2.73]). Stratified analysis by sex and age also showed no significant difference between F%E and incidence of CVD. When %E from saturated fatty acids (SFA%E) was analyzed according to quartiles 1 and 4 SFA%E values were 4.9%E and 7.1%E, respectively. There were no significant differences in incidence of CVD among quartiles (Q1: Reference, Q2: 1.31 [0.66-2.61], Q3: 0.47 [0.18-1.25], and Q4: 1.02 [0.44-2.39]). Findings suggested that most Japanese with T2D during the study period consumed &amp;lt; 30% of F%E and &amp;lt;10% of SFA%E. No significant differences in incident CVD were observed within these ranges.

    Disclosure

    C. Horikawa: None. M. Takahara: None. N. Katakami: Speaker's Bureau; Abbott Japan Co., Ltd., Kowa Company, Ltd., MSD, Mitsubishi Tanabe Pharma Corporation, Lilly Diabetes, Ono Pharmaceutical Co., Ltd., Sumitomo Dainippon Pharma Co., Ltd., Teijin Pharma Limited, Kyowa Kirin Co., Ltd., Daiichi Sankyo, Boehringer-Ingelheim, Sanofi. Y. Takeda: None. M. Takeuchi: None. K. Fujihara: None. H. Suzuki: Speaker's Bureau; Abbott Japan Co., Ltd., Sumitomo Dainippon Pharma Co., Ltd., Novo Nordisk, Kissei Pharmaceutical Co., Ltd., Kowa Company, Ltd., Boehringer-Ingelheim, Terumo Corporation, AstraZeneca, Bayer Inc., Kyowa Kirin Co., Ltd. N. Yoshioka: None. H. Shimano: None. J. Satoh: Speaker's Bureau; Lilly Diabetes, Merck &amp; Co., Inc., Ono Pharmaceutical Co., Ltd., Sanofi, Sumitomo Dainippon Pharma Co., Ltd., Boehringer-Ingelheim. Y. Hayashino: Speaker's Bureau; Eli Lilly and Company, Merck &amp; Co., Inc., Boehringer-Ingelheim, Sanofi, Sumitomo Dainippon Pharma Co., Ltd., Novo Nordisk A/S. N. Tajima: None. R. Nishimura: Speaker's Bureau; Abbott. Advisory Panel; Abbott Japan Co., Ltd. Speaker's Bureau; Boehringer-Ingelheim, Mitsubishi Tanabe Pharma Corporation, Kowa Company, Ltd., Medtronic, Sanofi, Taiho Pharmaceutical Co. Ltd., Sumitomo Dainippon Pharma Co., Ltd., Teijin Pharma Limited, Eli Lilly and Company, Novo Nordisk A/S. Consultant; Terumo Corporation. Y. Yamasaki: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    Funding

    The Japan Diabetes Society, the Japan Society for the Promotion of Science(23K10873).

    DOI: 10.2337/db24-1372-p

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  • 1474-P: Cross-Sectional and Longitudinal Relationships between Detailed Family History (FH) of Type 2 Diabetes Mellitus (T2DM), Hypertension (HT), and Dyslipidemia (DL) and Prevalence of Each Disorder

    IZUMI IKEDA, KAZUYA FUJIHARA, YASUNAGA TAKEDA, MARIKO HATTA, SIJIA WU, SATORU KODAMA, YASUMICHI MORI, TAKASHI KADOWAKI, RITSUKO YAMAMOTO-HONDA, YASUJI ARASE, HIROHITO SONE

    Diabetes   73 ( Supplement_1 )   2024年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    A FH of T2DM, HT, and DL are known risk factors; however, few studies have compared the impact of a FH of the 3 diseases in the same population. We examined the impact of a detailed FH of these conditions (i.e., in fathers, mothers, siblings and grandparents) on their prevalence and incidence in the study population. Data on 41,931 participants who underwent health checkups were examined and the results of a logistic regression and (Cox regression model in the same cohort were examined. Results of the cross-sectional study showed that odds ratios increased with the degree of a positive FH for all three diseases. Furthermore, in T2DM, the group with a three-generation positive FH was approximately 20 times larger than the control group which had no FH (Figure). In the longitudinal study, FH had a strong influence on the incidence of T2DM, HT, and DL, in that order, with a hazard ratio of 2.40 (1.93-2.98) for T2DM. A detailed FH was extremely useful for both quantitative screening for each disease and predicting the incidence of the three diseases, especially T2DM, for which a high risk was indicated in multiple generations with overlapping of positivity for a particular disease.

    <p></p> Disclosure

    I. Ikeda: None. K. Fujihara: None. Y. Takeda: None. M. Hatta: None. S. Wu: None. S. Kodama: None. Y. Mori: None. T. Kadowaki: None. R. Yamamoto-Honda: None. Y. Arase: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

    DOI: 10.2337/db24-1474-p

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  • 詳細な家族歴が2型糖尿病,高血圧,脂質異常症の有病と発症に与える影響の横断縦断的検討

    池田 和泉, 五十嵐 理沙, 藤原 和哉, 武田 安永, 松林 泰弘, 児玉 暁, 山田 貴穂, 森 保道, 門脇 孝, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   67 ( Suppl.1 )   S - 194   2024年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Higher dietary protein/energy ratio is associated with a lower risk for obesity in older women with type 2 diabetes: Cross-sectional analysis of Japanese patients with type 2 diabetes mellitus

    Efrem d'Ávila Ferreira, Mariko Hatta, Khin Laymon, Izumi Ikeda, Mizuki Takeuchi, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Chika Horikawa, Noriko Kato, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

    Human Nutrition &amp; Metabolism   200257 - 200257   2024年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.hnm.2024.200257

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  • Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

    Masahiro Ishizawa, Kazuya Fujihara, Junko Yachida, Izumi Ikeda, Takaaki Sato, Takaho Yamada, Ayako Kobayashi, Shiro Tanaka, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Minoru Tashiro, Satoru Kodama, Kiminori Kato, Hirohito Sone

    Journal of Bone Metabolism   31 ( 1 )   21 - 30   2024年2月

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    掲載種別:研究論文(学術雑誌)  

    Background: No consensus exists regarding which anthropometric measurements are related to bone mineral density (BMD), and this relationship may vary according to sex and age. A large Japanese cohort was analyzed to provide an understanding of the relationship between BMD and anthropometry while adjusting for known confounding factors. Methods: Our cohort included 10,827 participants who underwent multiple medical checkups including distal forearm BMD scans. Participants were stratified into four groups according to age (≥50 years or <50 years) and sex. The BMD values were adjusted for confounding factors, after which single and partial correlation analyses were performed. The prevalence of osteopenia was plotted for each weight index (weight or body mass index [BMI]) class. Results: Cross-sectional studies revealed that weight was more favorably correlated than BMI in the older group (R=0.278 and 0.212 in men and R=0.304 and 0.220 in women, respectively), whereas weight and BMI were weakly correlated in the younger age groups. The prevalence of osteopenia exhibited a negative linear relationship with weight among older women ≥50 years of age, and an accelerated increase was observed with decreasing weight in older men weighing <50 kg and younger women weighing <60 kg. When weight was replaced with BMI, the prevalence was low in most subgroups classified by weight. Conclusions: Weight, rather than BMI, was the most important indicator of osteopenia but it might not be predictive of future bone loss.

    DOI: 10.11005/jbm.2024.31.1.21

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  • 副交感神経障害を伴わず糖尿病性動眼神経麻痺との鑑別に難渋した下垂体卒中による動眼神経麻痺の一例

    深井 悠未, 村井 幸四郎, 今西 明, 矢口 雄大, 北澤 勝, 鈴木 浩史, 松林 泰弘, 藤原 和哉, 岩永 みどり, 山田 貴穂, 曽根 博仁, 岡田 正康

    日本内分泌学会雑誌   99 ( 4 )   895 - 895   2024年1月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 機能性甲状腺結節による甲状腺中毒症を誘因として糖尿病性ケトアシドーシスを来し甲状腺クリーゼを発症した一例

    間島 貴之, 鈴木 浩史, 木村 智佑, 佐藤 隆明, 山本 雅彦, 石黒 創, 岩永 みどり, 松林 泰弘, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   99 ( 4 )   884 - 884   2024年1月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Association between screen time, including that for smartphones, and overweight/obesity among children in Japan: NICE EVIDENCE Study 4

    Izumi Ikeda, Kazuya Fujihara, Sakiko Morikawa Yoshizawa, Yasunaga Takeda, Hajime Ishiguro, Mayuko Yamada Harada, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Yohei Ogawa, Hirohito Sone

    Endocrine Journal   2024年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Endocrine Society  

    DOI: 10.1507/endocrj.ej23-0343

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  • isCGMとPHRスマートフォンアプリを用いた糖尿病発症予防プログラムの有効性検証のためのランダム化比較試験

    北澤 勝, 武田 安永, 治田 麻理子, 堀川 千嘉, 佐藤 隆明, 大澤 妙子, 石澤 正博, 鈴木 浩史, 松林 泰弘, 藤原 和哉, 山田 貴穂, 曽根 博仁

    日本先進糖尿病治療研究会雑誌   17 ( 3 )   152 - 152   2023年12月

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    記述言語:日本語   出版者・発行元:日本先進糖尿病治療研究会  

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  • "Lifestyle Intervention with Smartphone app and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial". 国際誌

    Masaru Kitazawa, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Takaaki Sato, Taeko Osawa, Masahiro Ishizawa, Hiroshi Suzuki, Yasuhiro Matsubayashi, Kazuya Fujihara, Takaho Yamada, Hirohito Sone

    The Journal of clinical endocrinology and metabolism   2023年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Although conventional interventions for people at high risk of developing type 2 diabetes are usually conducted face-to-face, such interventions are burdensome for healthcare providers. We developed a lifestyle intervention program combining lifestyle coaching via a smartphone application augmented by intermittently scanned continuous glucose monitoring (isCGM) without burdening healthcare providers. Its effectiveness for glycemic control and body weight reduction in people at risk of type 2 diabetes was investigated. MATERIALS AND METHODS: For this 12-week randomized unblinded trial with offline recruitment, participants with HbA1c 5.6-6.4% or fasting blood glucose 110-125 mg/dl and body mass index (BMI) > 23 kg/m2 but <40 kg/m2 were randomly assigned to the Intervention group (App) and Control group (C). Primary endpoint was the difference in time in range (TIR) of blood glucose 70-140 mg/dL (3.9-7.8 mmol/L) before and after the study period between the two groups. RESULTS: Among 168 patients (mean age 48.1 y, mean BMI 26.6 kg/m2, and male 80.4%), 82 and 86 were assigned to the App group and C group, respectively. After 12 weeks, TIR of blood glucose 70-140 mg/dL significantly improved in the App group compared to the C group (-2.6 min/day vs. + 31.5 min/day, p = 0.03). Changes in time above range did not differ, whereas time below range (blood glucose <70 mg/dL;  + 23.5 min/day vs. -8.9 min/day, p = 0.02) improved in the App group. BMI (-0.26 vs. -0.59, p = 0.017) was reduced in the App group compared to the C group. CONCLUSION: Intervention with a smartphone app and isCGM increased glycemic control accompanied by decreased carbohydrate intake and weight loss. Further trials are needed to confirm whether these interventions can reduce incident type 2 diabetes.

    DOI: 10.1210/clinem/dgad639

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  • 血糖コントロールと妊娠合併症リスクとの量反応関係メタ回帰分析

    児玉 暁, 山田 貴穂, 柳生田 紀子, 谷内 洋子, 堀川 千嘉, 大澤 妙子, 北澤 勝, 藤原 和哉, 西島 浩二, 曽根 博仁

    糖尿病と妊娠   23 ( 3 )   S - 109   2023年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病・妊娠学会  

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  • 溶血性貧血によるヘモクロマトーシスと甲状腺機能低下症の合併例

    村井 幸四郎, 矢口 雄大, 今西 明, 深井 悠未, 北澤 勝, 鈴木 浩史, 佐藤 隆明, 石黒 創, 山本 正彦, 石澤 正博, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   99 ( 2 )   599 - 599   2023年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 頭蓋咽頭腫術後の視床下部障害から低体温症を来した1例

    赤壁 尚太, 土田 大介, 滝澤 大輝, 北澤 勝, 松林 泰弘, 山田 貴穂, 藤原 和哉, 平石 哲也, 大石 誠, 曽根 博仁

    日本内分泌学会雑誌   99 ( 2 )   591 - 591   2023年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 血糖コントロールと妊娠合併症リスクとの量反応関係メタ回帰分析

    児玉 暁, 山田 貴穂, 柳生田 紀子, 谷内 洋子, 堀川 千嘉, 大澤 妙子, 北澤 勝, 藤原 和哉, 西島 浩二, 曽根 博仁

    糖尿病と妊娠   23 ( 3 )   S - 109   2023年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病・妊娠学会  

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  • 心血管疾患 脂肪肝の表現型,及び2型糖尿病が心不全の新規発症に与えるインパクト

    松林 泰弘, 藤原 和哉, 山田 万祐子, 佐藤 隆明, 矢口 雄大, 山本 正彦, 石黒 創, 大澤 妙子, 北澤 勝, 岩永 みどり, 山田 貴穂, 曽根 博仁

    糖尿病合併症   37 ( Suppl.1 )   164 - 164   2023年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 網膜症 2型糖尿病男性におけるアルコール摂取と重症糖尿病眼疾患発症の関連

    山本 正彦, 藤原 和哉, 長谷部 日, 山田 万祐子, 矢口 雄大, 大澤 妙子, 岩永 みどり, 児玉 暁, 山田 貴穂, 曽根 博仁

    糖尿病合併症   37 ( Suppl.1 )   135 - 135   2023年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • Associations among metabolic health, weight status, and various physical fitness components in Japanese adolescents: a cross-sectional study (NICE EVIDENCE study- Agano 3). 国際誌

    Sakiko Yoshizawa Morikawa, Yasunaga Takeda, Kazuya Fujihara, Izumi Ikeda, Ayako Kobayashi, Mariko Hatta, Yurie Mitsuma, Chika Horikawa, Hajime Ishiguro, Takaho Yamada, Yohei Ogawa, Hirohito Sone

    Journal of sports sciences   41 ( 13 )   1279 - 1289   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aim was to examine associations among metabolic health, weight status, and various physical fitness (PF) components in 1744 Japanese adolescents aged 13-14. Anthropometric measurements and PF tests (20 m shuttle run test [20mSRT], handgrip strength/body mass [HG], standing long jump [SLJ], and sit ups [SU]) were administered. The bottom sex-specific quintile of PF indicated "low fit". Participants were classified as non-overweight (non-OW) or overweight/obese (OW) according to the International Obesity Task Force. Clustered metabolic risk was defined as the sum of Z scores for mean arterial pressure, non-high-density lipoprotein cholesterol, and HbA1c, divided by three, and ≥ 1 SD. Combination of weight status and scores for HG or SU were additively associated with clustered metabolic risk. Compared with the non-OW-moderate-high fit group, the OW-low HG group was 3.05 (95%CI: 1.88-4.97) times more likely to have clustered metabolic risk although risk was not significantly elevated in the OW-moderate-high HG group (1.52 [95%CI: 0.88-2.62]). A similar association was observed between OW and low SU scores but not between OW and low 20mSRT or SLJ scores. Adolescents with OW and moderate-high HG or SU scores had a lower prevalence of an unfavourable metabolic state than those with OW and low HG or SU results.

    DOI: 10.1080/02640414.2023.2268358

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  • Relationship between the magnitude of body mass index reductions and remission in patients with type 2 diabetes in real world settings: Analysis of Nationwide Patient Registry in Japan (JDDM74). 査読 国際誌

    Fujihara K, Khin L, Murai K, Yamazaki Y, Tsuruoka K, Yagyuda N, Yamazaki K, Maegawa H, Tanaka S, Kodama S, Sone, H, JDDM Study Group

    Diabetes Obes Metab   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: To determine the association between the magnitude of weight loss and incidence of remission according to baseline characteristics in patients with diabetes in clinical settings. METHODS: In total, 39 676 Japanese patients with type 2 diabetes aged ≥18 years with glycated haemoglobin (HbA1c) ≥6.5% and/or glucose-lowering drug prescription were identified from databases of specialists' clinics from 1989 and followed until September 2022. Remission was diagnosed as maintaining HbA1c <6.5% at least 3 months after cessation of a glucose-lowering drug. Factors associated with remission were evaluated by logistic regression analysis according to weight change in 1 year (i.e. ≥10%, 7.0-9.9%, 3.0-6.9% reduction, <3% change and ≥3.0% increase). RESULTS: During the study period, 3454 remissions occurred. The rates of remission were higher in the group with the greatest reduction of body mass index (BMI) in any category examined (i.e. baseline BMI, HbA1c, duration of diabetes and treatment). The incidences of remission per 1000 person-years were about 25 and 50, respectively, for those with BMI ≥22.5 and reductions in BMI of 7.0-9.9% and ≥10% in 1 year. Remissions per 1000 person-years were 99.2 and 91.8, respectively, for those with baseline HbA1c of 6.5-6.9 and a 10% BMI reduction and those not taking glucose-lowering drugs accompanied by a 10% BMI reduction. CONCLUSIONS: Modest weight losses of 3.0-7.9% were significantly associated with remission, but a minimum of 10% weight loss would be required in addition to an early diagnosis to achieve a 10% remission rate in clinical settings. Our results implied that remission may be expected with a relatively lower BMI in an Asian population compared with that was reported in Western populations if accompanied by weight loss.

    DOI: 10.1111/dom.15206

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  • Retrospective cohort study to examine the association between serum amylase and the incidence of type 2 diabetes mellitus, Toranomon Hospital Health Management Center Study 23 (TOPICS 23). 国際誌

    Izumi Ikeda, Kazuya Fujihara, Taeko Osawa, Yasunaga Takeda, Mariko Hatta, Yasuhiro Matsubayashi, Satoru Kodama, Yasumichi Mori, Takashi Kadowaki, Ritsuko Honda, Yasuji Arase, Hirohito Sone

    BMJ open diabetes research & care   11 ( 4 )   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Low serum amylase values are cross-sectionally associated with the prevalence of type 2 diabetes mellitus (T2DM) but have not been shown to be longitudinally associated with its incidence. This retrospective cohort (ie, historical cohort) study aimed to examine the association of previously lowered levels of serum amylase with incident T2DM. RESEARCH DESIGN AND METHODS: Examined were 8316 individuals who had annual health examinations for 6 years (ie, 7 times) at the Toranomon Hospital Health Management Center. The trajectory of serum amylase as the study exposure was classified into two elements: (1) serum amylase level at entry and (2) change in serum amylase, which was expressed as the annual change rate. The annual change rate was calculated by dividing the change in the amylase values according to follow-up periods. Regression analyses were performed to examine the association between low and decreased levels of serum amylase and the incidence of T2DM. RESULTS: Analyzed were 6917 individuals who had not developed T2DM within 1 year after cohort entry. T2DM thereafter occurred in 1021 patients. Cox regression indicated that the adjusted HR (95% CI) for incident T2DM for amylase ≤57 IU/L (quintile (Q) 1) was 0.97 (0.84 to 1.13) compared with amylase ≥58 IU/L (Q2-Q5). Logistic regression indicated that the adjusted OR (95% CI) for an annual change rate of amylase ≤-2.0% (Q1) vs ≥-1.9% (Q2-Q5) was 3.53 (3.00 to 4.16). The adjusted ORs were consistently significant throughout sensitivity analyses according to baseline amylase and the combination of age, body mass index, and hemoglobin A1c. CONCLUSIONS: Results showed that not low but previously decreased serum amylase was a risk factor for T2DM, suggesting the significance of periodic examinations of serum amylase values to detect individuals at high risk of T2DM.

    DOI: 10.1136/bmjdrc-2023-003482

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  • エンフォルツマブによる高血糖と回腸導管による代謝性アシドーシスをきたした1例

    浅島 雄弥, 佐藤 隆明, 佐々木 知佳, 鈴木 浩史, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    糖尿病   66 ( 7 )   568 - 568   2023年7月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 劇症1型糖尿病発症時にST上昇を呈し偽性心筋梗塞と考えられた1例

    佐藤 駿匡, 北澤 勝, 滝澤 祥子, 今西 明, 山田 万祐子, 松林 泰弘, 藤原 和哉, 山田 貴穂, 保屋野 真, 曽根 博仁

    糖尿病   66 ( 7 )   570 - 570   2023年7月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 329-OR: Accuracy of Dietary Records (DR) Using a Smartphone App Is Greatly Improved by User’s Adjustments Compared with Artificial Intelligence (AI) Alone

    MASARU KITAZAWA, CHIKA HORIKAWA, IZUMI IKEDA, YASUNAGA TAKEDA, EFREM D. FERREIRA, MIZUKI TAKEUCHI, SAKIKO Y. MORIKAWA, KAZUYA FUJIHARA, SATORU KODAMA, HIROHITO SONE

    Diabetes   72 ( Supplement_1 )   2023年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Although DR are important in managing diabetes, the traditional method, such as weighing foods and calculating nutrients, is burdensome to both patients and medical care providers. Although photo DR with smartphones using AI to identify the dish and calculate nutrients can be expected to reduce this burden, accuracy not been clarified. Furthermore, it is not clear to what extent accuracy improves when users and dietitians adjust the name of the dish and the portion consumed compared with AI only. In this study, photo DR taken with the smartphone app were analyzed by AI only, then adjusted by the users followed by further adjustments by a dietitian. We compared the nutrients calculated by AI, users, and dietitians to those by the traditional weighing method. Analyzed were 180 participants (mean age 58.7 y, BMI 26.7 kg/m2, 94/86 women/men, 22 with diabetes, energy intake [EI] 1640 kcal/day) The EIs (kcal/day) were calculated as 1502, 1619, and 1674 for AI, users, and dietitians, respectively, those were lower than that with the weighing method Spearman's rank correlation coefficients compared to the weighing method were 0.48, 0.88, and 0.88 for AI, users and dietitians, respectively, showing a weak correlation for AI and a strong correlation for users and dietitians. The user's adjustments greatly improved accuracy without increasing the burden on the dietitians.

    <p></p> Disclosure

    M.Kitazawa: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. C.Horikawa: None. I.Ikeda: None. Y.Takeda: None. E.D.Ferreira: None. M.Takeuchi: None. S.Y.Morikawa: None. K.Fujihara: None. S.Kodama: None.

    Funding

    Grants-in-Aid for Scientific Research (21K17637)

    DOI: 10.2337/db23-329-or

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  • 1381-P: Effect of Dietary Potassium Intake and Its Interaction with Sodium Intake on Risk of Developing Cardiovascular Disease (CVD) in Persons with Type 2 Diabetes (T2D)—Japan Diabetes Complication and Its Prevention Prospective Study (JDCP Study)

    CHIKA HORIKAWA, MITSUYOSHI TAKAHARA, NAOTO KATAKAMI, YASUNAGA TAKEDA, MIZUKI TAKEUCHI, KAZUYA FUJIHARA, HIROAKI SUZUKI, KINSUKE TSUDA, NARIHITO YOSHIOKA, HITOSHI SHIMANO, JO SATOH, YASUAKI HAYASHINO, NAOKO TAJIMA, RIMEI NISHIMURA, YOSHIMITSU YAMASAKI, HIROHITO SONE

    Diabetes   72 ( Supplement_1 )   2023年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Many guidelines recommend increased potassium intake. However, the relationship between dietary potassium intake and incidence of CVD in persons with T2D has not been explored, nor is it known if this relationship varies with sodium intake in such persons. Therefore, we investigated these relationships as part of the JDCP study, a nationwide study launched in 2007. A total of 1477 persons with T2D aged 40-75 years completed a brief self-administered Diet History Questionnaire at baseline, and resultant data were analyzed. Primary outcome was the 7-year risk of a CVD event. Hazard ratios (HRs) for CVD according to tertiles of dietary potassium and sodium intake were estimated by Cox regression adjusted for confounders in addition to a stratified analysis of tertiles of sodium intake. Mean daily potassium and sodium intakes in tertiles 1 to 3 were 1.9, 2.6, and 3.5 g and 3.3, 4.2, and 5.3 g, respectively. HbA1c, BMI, triglycerides, and blood pressure were well controlled. No significant associations between potassium and sodium intakes and incidence of CVD were shown for the second and third tertiles relative to the first tertile (potassium: 0.64 [95% CI, 0.34-1.23] and 0.59 [0.28-1.25]; sodium: 1.02 [0.51-2.04] and 1.15 [0.58-2.30]). In the stratified analysis of tertiles of sodium intake, in the high sodium intake groups (T2 and T3) HRs for CVD in the high potassium intake group were significantly lower compared to the low potassium intake group (T2: 0.40 [0.12-1.35] and 0.06 [0.01-0.69]; T3: 0.23 [0.07-0.82] and 0.26 [0.07-0.88]). Associations of potassium intake with CVD in those with low sodium intake (T1) were not significant. Findings suggested that high potassium intake under high sodium intake is associated with a deceased incidence of CVD in persons with T2D although potassium intake under low sodium intake was not associated with incident CVD.

    Disclosure

    C.Horikawa: None. H.Shimano: None. J.Satoh: None. Y.Hayashino: Advisory Panel; Novo Nordisk A/S, Ono Pharmaceutical Co., Ltd., Speaker's Bureau; Boehringer Ingelheim Japan, Inc., Sumitomo Dainippon Pharma Co., Ltd., Santen, Daiichi Sankyo, Kowa Company, Ltd. N.Tajima: None. R.Nishimura: Speaker's Bureau; Sanofi K.K., Medicure Inc., Boehringer Ingelheim Inc., Takeda Pharmaceutical Company Limited, Kissei Pharmaceutical Co., Ltd., Novartis Pharma K.K., Eli Lilly Japan K.K., Novo Nordisk, Merck &amp; Co., Inc., Abbott Japan Co., Ltd., Astellas Pharma Inc., Teijin Pharma Limited, Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., AstraZeneca. Y.Yamasaki: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. Jdcp study group: n/a. M.Takahara: None. N.Katakami: Speaker's Bureau; Abbott Japan Co., Ltd., Daiichi Sankyo, MSD, Mitsubishi Tanabe Pharma Corporation, Kowa Company, Ltd., Ono Pharmaceutical Co., Ltd., Novo Nordisk, Sumitomo Dainippon Pharma Co., Ltd., Bayer Inc., Lilly, Teijin Pharma Limited, Kyowa Kirin Co., Ltd., Boehringer Ingelheim Japan, Inc., Sanofi. Y.Takeda: None. M.Takeuchi: None. K.Fujihara: None. H.Suzuki: None. K.Tsuda: None. N.Yoshioka: None.

    DOI: 10.2337/db23-1381-p

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  • 1713-P: Dietary Manganese (Mn) Intake Is Independently Associated with a Lower BMI in Younger Japanese with Type 2 Diabetes Mellitus (T2DM)

    LAY MON KHIN, KAZUYA FUJIHARA, MARIKO HATTA, YASUNAGA TAKEDA, SAKIKO Y. MORIKAWA, CHIKA HORIKAWA, NORIKO KATO, MITSUTOSHI KATO, HIROSHI MAEGAWA, HIROHITO SONE

    Diabetes   72 ( Supplement_1 )   2023年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    We analyzed the association between dietary Mn intake and obesity measured by BMI after adjustment for intake of nutrients and food groups in people with T2DM in Japan. Participants were 1567 people, 63% male, aged 30 to 89 y who were in the Japan Diabetes Clinical Data Management Study Group (JDDM), one of the largest cohorts of Japanese with diabetes. Intake of food groups was determined by a validated self-administered food frequency questionnaire based on food groups. Obesity was defined as BMI ≥25 kg/m2. Multivariate logistic regression analysis assessed the relationship between quartiles of dietary Mn intake and obesity stratified by age. Participants aged 30 to 89 y were grouped according to the following quartiles for age: 30-54 y, 55-63 y, 64-71 y, and 72-89 y. Compared to the lowest quartile (Q1) for Mn, a significant negative association between Mn and BMI was found in males for all quartiles of Mn (OR [95%CI] of Q2= 0.643 [0.424 - 0.973], Q3= 0.607 [0.374 - 0.986], Q4= 0.398 [0.218 - 0.728], p trend = 0.028) with adjustment for characteristics such as age, sex, current smoking, drinking, insulin, oral hypoglycemic agents treatment, activity, energy intake and macronutrients intake. However, statistical significance disappeared after adding total fiber as a covariate. Compared to the lowest quartile for Mn, the highest quartile of Mn was inversely associated with BMI in the younger age group (30-54 y [OR= 0.296 [0.088 - 0.996]]) even after total fiber adjustment. Multivariate analysis of food groups (rice, vegetables, soy products) that were highly correlated with Mn as covariates showed that the relationships between Mn intake and obesity were maintained (p trend for rice, vegetables, soy = &amp;lt;0.001, 0.187, 0.010) in all participants. In summary, higher dietary Mn intake was independently associated with a lower BMI, especially in the younger group and males. Future prospective or intervention studies are expected to confirm this result.

    Disclosure

    L.Khin: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. Jddm study group: n/a. K.Fujihara: None. M.Hatta: None. Y.Takeda: None. S.Y.Morikawa: None. C.Horikawa: None. N.Kato: None. M.Kato: None. H.Maegawa: None.

    DOI: 10.2337/db23-1713-p

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  • 738-P: Lifestyle Intervention Program with Smartphone App Augmented by Intermittently Scanned Continuous Glucose Monitoring for People at High Risk of Diabetes—Randomized Controlled Trial

    MASARU KITAZAWA, HIROSHI SUZUKI, CHIKA HORIKAWA, YASUNAGA TAKEDA, IZUMI IKEDA, MARIKO HATTA, MIDORI IWANAGA, TAKAHO YAMADA, KAZUYA FUJIHARA, HIROHITO SONE

    Diabetes   72 ( Supplement_1 )   2023年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    We examined the effects of a lifestyle intervention program with a smartphone app augmented by intermittently scanned continuous glucose monitoring (isCGM) of persons at high risk of developing diabetes in a 12-week randomized open-label trial (UMIN00004640). The program monitored blood glucose fluctuations and lifestyle habits and displayed them in an easy-to-understand interface as well as provided personalized lifestyle intervention messages. The primary endpoint was the change in time in range (TIR) of 70-140 mg/dL between intervention (App) and control (C) groups. Among 168 patients (mean age 48.1 y, mean BMI 26.6 kg/m2, and male 80.4%), 82 and 86 were assigned to the App group and C group, respectively. After 12 weeks, TIR of 70-140 mg/dL significantly improved in the App group compared to the C group (-2.6 min/day vs. +31.5 min/day, p=0.03). Changes in time above range (&amp;gt;140 mg/dL; -20.9 min/day vs. -22.6 min/day, p=0.86) did not differ, whereas time below range (&amp;lt;70 mg/dL; +23.5 min/day vs. -8.9 min/day, p=0.02) improved in App compared to C. BMI (-0.26 vs. -0.59, p=0.017) and carbohydrate intake (-4.4 kcal/day vs. -22.7 kcal/day, p=0.049) also improved in App compared to C. Intervention with a smartphone app and isCGM increased glycemic control with a decrease in carbohydrate intake and weight loss.

    <p></p> Disclosure

    M.Kitazawa: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. H.Suzuki: None. C.Horikawa: None. Y.Takeda: None. I.Ikeda: None. M.Hatta: None. M.Iwanaga: None. T.Yamada: None. K.Fujihara: None.

    DOI: 10.2337/db23-738-p

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  • 1357-P: Conflicting Significance of High BMI as a Predictor of Individual Diabetic Complications

    YUTA YAGUCHI, KAZUYA FUJIHARA, LAY MON KHIN, SIJIA WU, EFREM D. FERREIRA, TAKAAKI SATO, CHIKA HORIKAWA, YASUHIRO MATSUBAYASHI, KIMINORI KATO, HIROHITO SONE

    Diabetes   72 ( Supplement_1 )   2023年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    Although weight management plays a central role in diabetes treatment, the association between body weight and diabetic complications is not fully elucidated. Therefore, we investigated the relationship between BMI and risk of diabetic complications in patients with diabetes mellius (DM) using nationwide claims data. Analyzed were 91097 patients with DM without prior treatment-requiring diabetic eye disease (TRDED), initiation of dialysis (dialysis), coronary artery disease (CAD), cerebrovascular disease (CVD), heart failure (HF) or amputation (mean age 52 y, HbA1c 7.2%, median follow-up 4.5 y). Participants were divided into 6 groups according to BMI (BMI&amp;lt;20.0, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.0, ≥30.0). Risk of diabetic complications was examined by Cox regression analysis. There was an inverse correlation between the risk of dialysis and BMI; hazard ratio (HR) for dialysis in patients with BMI ≥30.0 was 0.46 (0.29-0.74). There was a U-shaped relationship between the risk of HF and BMI; HRs for HF in patients with BMI &amp;lt;20.0 and ≥30.0 were 1.97 (1.15-3.37) and 1.76 (1.27-2.45), respectively (Figure). High BMI was significantly associated with a higher risk of HF, but lower risks of TRDED and dialysis. The relationship between BMI and diabetic complications was inconsistent among complications, suggesting that the target weight should be individualized according to diabetic complications.

    <p></p> Disclosure

    Y.Yaguchi: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. K.Fujihara: None. L.Khin: None. S.Wu: None. E.D.Ferreira: None. T.Sato: None. C.Horikawa: None. Y.Matsubayashi: None. K.Kato: None.

    DOI: 10.2337/db23-1357-p

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  • Incidence and predictors of remission and relapse of type 2 diabetes mellitus in Japan: Analysis of a nationwide patient registry (JDDM73). 査読 国際誌

    Fujihara K, Khin L, Murai K, Yamazaki Y, Tsuruoka K, Yagyuda N, Yamazaki K, Maegawa H, Tanaka S, Kodama S, Sone H, JDDM Study Group

    Diabetes Obes Metab   25 ( 8 )   2227 - 2235   2023年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: To determine the incidence of remission and 1-year relapse from remission and associated factors in patients with type 2 diabetes. MATERIALS AND METHODS: A total of 48 320 Japanese patients with type 2 diabetes aged ≥18 years, with glycated haemoglobin (HbA1c) levels ≥48 mmol/mol (6.5%) and/or glucose-lowering drug prescription, were identified from databases of specialist clinics from 1989 and followed until September 2022. Remission was defined as HbA1c <48 mmol/mol at least 3 months after cessation of a glucose-lowering drug. Relapse was defined as failure to maintain remission for 1 year. Factors associated with remission and relapse were evaluated by logistic regression analysis. RESULTS: The overall incidence of remissions per 1000 person-years was 10.5, and for those with HbA1c levels of 48 to 53 mmol/mol (6.5% to 6.9%), those taking no glucose-lowering drugs at baseline, and those with a ≥10% body mass index (BMI) reduction in 1 year, it was 27.8, 21.7 and 48.2, respectively. Shorter duration, lower baseline HbA1c, higher baseline BMI, higher BMI reduction at 1 year, and no glucose-lowering drugs at baseline were significantly associated with remission. Among 3677 persons with remission, approximately two-thirds (2490) relapsed within 1 year. Longer duration, lower BMI at baseline, and lower BMI reduction at 1 year were significantly associated with relapse. CONCLUSIONS: The results showed that the incidence of remission and predictors of relapse, especially baseline BMI, might differ greatly between East Asian and Western populations. Furthermore, the relationships of BMI reduction with remission and relapse may be greater in East Asian than in Western populations, implying ethnic differences in returning from overt hyperglycaemia to nearly normal glucose levels.

    DOI: 10.1111/dom.15100

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  • 中学生におけるスクリーンタイムがボディイメージの歪みと精神的健康度へ及ぼす影響

    池田 和泉, 藤原 和哉, 森川 咲子, 武田 安永, 石黒 創, 堀川 千嘉, 山田 貴穂, 小川 洋平, 曽根 博仁

    日本内分泌学会雑誌   99 ( 1 )   333 - 333   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia. 査読

    Kodama S, Fujihara K, Ishiguro H, Matsubayashi Y, Kitazawa M, Iwanaga M, Yamada T, Kato K, Nakagawa Y, Tanaka S, Shimano H, Sone H

    J Investig Med   2023年4月

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    記述言語:英語  

    DOI: 10.1177/10815589221149188

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  • 写真撮影とAIを活用した食事記録スマートフォンアプリによる日常の食事記録の妥当性検証

    北澤 勝, 堀川 千嘉, 長谷川 美代, 武田 安永, 治田 麻理子, 松林 泰弘, 山田 貴穂, 児玉 暁, 藤原 和哉, 曽根 博仁

    糖尿病   66 ( Suppl.1 )   S - 230   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 耐糖能や年齢で層別化した血清アミラーゼ低値およびその経時的減少が2型糖尿病発症に及ぼす影響の縦断的検討

    池田 和泉, 藤原 和哉, 大澤 妙子, 武田 安永, 治田 麻里子, 松林 泰弘, 児玉 暁, 森 保道, 本田 律子, 門脇 孝, 荒瀬 康司, 曽根 博仁

    糖尿病   66 ( Suppl.1 )   S - 215   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 炭水化物エネルギー比率の算出方法の違いは、糖尿病患者の炭水化物エネルギー比率と心血管疾患発症リスクの関係に影響しうるか

    堀川 千嘉, 高原 充佳, 片上 直人, 武田 安永, 竹内 瑞希, 藤原 和哉, 鈴木 浩明, 津田 謹輔, 吉岡 成人, 押田 芳治, 島野 仁, 佐藤 譲, 林野 泰明, 田嶼 尚子, 西村 理明, 山崎 義光, 曽根 博仁

    日本栄養・食糧学会大会講演要旨集   77回   314 - 314   2023年3月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • Utility of a Physical Fitness Score in Screening for Chronic Diseases. 国際誌

    Takaaki Sato, Kazuya Fujihara, Mayuko Harada Yamada, Kaori Chou, Yuta Yaguchi, Masaru Kitazawa, Hajime Ishiguro, Taeko Osawa, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone

    Journal of sports science & medicine   22 ( 1 )   98 - 110   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We developed a new Physical Score (PS) consisting of comprehensive physical fitness indicators and elucidated the association between the resultant PS and metabolic diseases, i.e., diabetes, hypertension, dyslipidemia, fatty liver, and metabolic syndrome (MetS), among Japanese. Analyzed were 49,850 persons (30,039 men) aged 30 to 69 y who underwent physical fitness tests. Principal component analysis was performed on the correlation matrix of the physical fitness test results (relative grip strength, single-leg balance with eyes closed, and forward bending) according to sex and age. We defined the PS as the first principal component score. A formula was developed for various age groups comprised of men and women from 30 to 69 years of age from which the PS for each age and sex was calculated. The PS for both men and women was normally distributed with a value of 0 ± 1.15-1.16. Multivariate logistic regression analysis showed that the risk of metabolic diseases increased approximately 1.1-1.6 times per each 1-point reduction in the PS. The association between PS and MetS was particularly strong in that a 1-point reduction in the PS increased the risk of MetS by 1.54 times (95% confidence interval 1.46 to 1.62) in men and by 1.21 times (1.15 to 1.28) in women. The association between a lower PS and disease risk was stronger in younger men for fatty liver and in older men for MetS. Conversely, in women, the association between a lower PS and disease risk was stronger in older women for fatty liver and in younger women for MetS. For diabetes, hypertension, and dyslipidemia, the change in the impact of PS reductions across age groups was small. The PS is a useful and simple non-invasive tool for screening Japanese people for metabolic diseases.

    DOI: 10.52082/jssm.2023.98

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  • ソフトドリンクケトーシス治療中に腎性尿崩症が指摘された一例

    日向 裕大, 矢口 雄大, 砂田 大介, 川井 千尋, 山本 正彦, 石黒 創, 北澤 勝, 石澤 正博, 鈴木 浩史, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   98 ( 4 )   856 - 856   2023年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • エンフォルツマブによる高血糖と回腸導管による代謝性アシドーシスの1例

    浅島 雄弥, 佐藤 隆明, 佐々木 知佳, 鈴木 浩史, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曾根 博仁

    新潟医学会雑誌   137 ( 2 )   71 - 71   2023年2月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • Combined effects of blood pressure and glycemic status on risk of heart failure: a population-based study

    Ayako Kobayashi, Kazuya Fujihara, Mayuko Harada Yamada, Takaaki Sato, Yuta Yaguchi, Masaru Kitazawa, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Journal of Hypertension   Publish Ahead of Print   2023年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1097/hjh.0000000000003362

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  • Association of the estimated glomerular filtration rate (eGFR) and/or proteinuria to predict the risk of initiation of dialysis in people with and without diabetes.

    Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Yuta Yaguchi, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Diabetology international   14 ( 1 )   86 - 93   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: To determine the associations between combined urinary protein (UP) and a reduced estimated glomerular filtration rate (eGFR) and the risk of starting dialysis with or without diabetes mellitus (DM). METHODS: A nationwide database with claims data on 335,778 people with and without DM aged 19-72 years in Japan was used to elucidate the impact of the severities of UP and eGFR on starting dialysis. Initiation of dialysis was determined from claims using ICD-10 codes and medical procedures. Using multivariate Cox modeling, we investigated the severities of UP and eGFR to predict the initiation of dialysis with and without DM. RESULTS: Both eGFR < 60 and UP(+) were independent predictors for starting dialysis with and without DM, and their values exhibited a synergistic risk of dialysis. eGFR < 60 presented a nearly twofold risk for starting dialysis compared to UP(+) regardless of DM. Risk of starting dialysis was increased with UP(+) and eGFR ≥ 60 accompanied by DM although this association was not observed without DM. Those who had UP(-) and eGFR < 60 had a high risk of starting dialysis regardless of DM. Compared with DM(-)UP(-)eGFR ≥ 60, HRs for starting dialysis for DM(+)UP(+)eGFR ≥ 60, DM(+)UP(-)eGFR < 60 and DM(+)UP(+)eGFR < 60 significantly increased 17.7 (10.6-29.7), 25.5 (13.8-47.1) and 358.1 (239.1-536.5) times, respectively. CONCLUSIONS: eGFR < 60 and UP(+) together presented an extremely high risk of dialysis especially with DM. UP( +) increased the risk of starting dialysis regardless of the eGFR with DM. Both patient education and a treatment strategy by physicians might be helpful to avoid the progression of renal failure.

    DOI: 10.1007/s13340-022-00603-z

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  • Machine learning approach to predict body weight in adults. 国際誌

    Kazuya Fujihara, Mayuko Yamada Harada, Chika Horikawa, Midori Iwanaga, Hirofumi Tanaka, Hitoshi Nomura, Yasuharu Sui, Kyouhei Tanabe, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone

    Frontiers in public health   11   1090146 - 1090146   2023年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Obesity is an established risk factor for non-communicable diseases such as type 2 diabetes mellitus, hypertension and cardiovascular disease. Thus, weight control is a key factor in the prevention of non-communicable diseases. A simple and quick method to predict weight change over a few years could be helpful for weight management in clinical settings. METHODS: We examined the ability of a machine learning model that we constructed to predict changes in future body weight over 3 years using big data. Input in the machine learning model were three-year data on 50,000 Japanese persons (32,977 men) aged 19-91 years who underwent annual health examinations. The predictive formulas that used heterogeneous mixture learning technology (HMLT) to predict body weight in the subsequent 3 years were validated for 5,000 persons. The root mean square error (RMSE) was used to evaluate accuracy compared with multiple regression. RESULTS: The machine learning model utilizing HMLT automatically generated five predictive formulas. The influence of lifestyle on body weight was found to be large in people with a high body mass index (BMI) at baseline (BMI ≥29.93 kg/m2) and in young people (<24 years) with a low BMI (BMI <23.44 kg/m2). The RMSE was 1.914 in the validation set which reflects ability comparable to that of the multiple regression model of 1.890 (p = 0.323). CONCLUSION: The HMLT-based machine learning model could successfully predict weight change over 3 years. Our model could automatically identify groups whose lifestyle profoundly impacted weight loss and factors the influenced body weight change in individuals. Although this model must be validated in other populations, including other ethnic groups, before being widely implemented in global clinical settings, results suggested that this machine learning model could contribute to individualized weight management.

    DOI: 10.3389/fpubh.2023.1090146

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  • デキサメタゾン投与後に周期性四肢麻痺を呈したバセドウ病の一例

    浅島 雄弥, 佐藤 隆明, 滝澤 大輝, 日向 裕大, 今西 明, 橋本 浩平, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   98 ( 2 )   583 - 583   2022年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 糖尿病性ケトアシドーシス治療中に腎性尿崩症が指摘された一例

    日向 裕大, 矢口 雄大, 砂田 大介, 川井 千尋, 山本 正彦, 石黒 創, 北澤 勝, 石澤 正博, 鈴木 浩史, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   136 ( 9 )   303 - 303   2022年9月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 尿細管障害を伴う低カリウム血症の加療中にデノスマブによる著明な低Ca血症をきたした1例

    砂田 大介, 矢口 雄大, 川井 千尋, 日向 裕大, 山本 正彦, 石黒 創, 北澤 勝, 石澤 正博, 鈴木 浩史, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   136 ( 9 )   303 - 303   2022年9月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 耐糖能およびHDL-C値によるLDL-C値が冠動脈疾患発症に及ぼす影響の検討

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病合併症   36 ( Suppl.1 )   173 - 173   2022年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 尿細管障害を伴う低カリウム血症の加療中にデノスマブによる著明な低Ca血症をきたした1例

    砂田 大介, 矢口 雄大, 川井 千尋, 日向 裕大, 山本 正彦, 石黒 創, 北澤 勝, 石澤 正博, 鈴木 浩史, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   136 ( 9 )   303 - 303   2022年9月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 糖尿病性ケトアシドーシス治療中に腎性尿崩症が指摘された一例

    日向 裕大, 矢口 雄大, 砂田 大介, 川井 千尋, 山本 正彦, 石黒 創, 北澤 勝, 石澤 正博, 鈴木 浩史, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   136 ( 9 )   303 - 303   2022年9月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • Predictors of hemoglobin and its changes focusing on anemia and polycythemia after administration of the SGLT2 inhibitor, tofogliflozin. 国際誌

    Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone

    Diabetes, obesity & metabolism   24 ( 12 )   2469 - 2473   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/dom.14836

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  • Fast walking and physical activity are independent contributors to improved physical function. 国際誌

    Haruka Shiozaki, Kazuya Fujihara, Mayuko Yamada-Harada, Masahiko Yamamoto, Yurie Mitsuma, Masaru Kitazawa, Yuta Yaguchi, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Family practice   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND OBJECTIVES: To clarify whether the presence or absence of fast walking and habitual physical activity are independently associated with the incidence of functional disability. METHODS: This historical cohort study was comprised of 9,652 (4,412 men, mean age 65 years) individuals aged 39-98 years without functional disability at baseline. Functional disability was determined based on the Japanese long-term care insurance system, which specified requirements for assistance in the activities of daily living. The impact of fast walking and habitual physical activity on the incidence of functional disability was analysed by Cox proportional hazards models. RESULTS: The follow-up period was a median of 3.7 years during which 165 patients were newly certified as having functional disability. In the multivariate analysis, baseline age in 5-year increments (hazard ratio 2.42 [95% confidence interval 2.18-2.69]), no habitual physical activity (1.56 [1.07-2.27]), and not fast walking (1.89 [1.32-2.69]) significantly increased the risk of functional disability after adjustment for covariates. The stratified analysis showed that compared with physical activity (+), the impact of physical activity (-) on the incidence of functional disability was observed in those aged ≥75 years regardless of fast walking (+). Fast walking (-) significantly increased the risk of disability compared with fast walking (+) in those aged <75 years regardless of a physical activity habit. CONCLUSION: In Japanese, slow walking speed and lack of a physical activity habit were shown to be independent risk factors for incident functional disability, with their impact differing according to age.

    DOI: 10.1093/fampra/cmac087

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  • Association between Obesity and Intake of Different Food Groups among Japanese with Type 2 Diabetes Mellitus-Japan Diabetes Clinical Data Management Study (JDDM68). 国際誌

    Mariko Hatta, Chika Horikawa, Yasunaga Takeda, Izumi Ikeda, Sakiko Yoshizawa Morikawa, Noriko Kato, Mitsutoshi Kato, Hiroki Yokoyama, Yoshio Kurihara, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

    Nutrients   14 ( 15 )   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: We investigated the association between various food groups and obesity in Japanese patients with type 2 diabetes. METHODS: 2070 patients with type 2 diabetes who attended 26 diabetes clinics throughout Japan were analyzed and were divided into obese and non-obese groups. Intakes of food groups determined by a food frequency questionnaire were compared. Odds ratios for obesity for quartiles of individual food groups were calculated using a logistic regression model. RESULTS: Non-obese patients consumed a larger variety of food groups than obese patients, with the diets of non-obese individuals closer to the traditional Japanese diet characterized by fish, seaweed, and soybeans/soy products. Among 21 food groups, low vegetable intake and high sweets intake were the most strongly associated with obesity in both men and women. Low intake of both fruits and vegetables and the combination of high intake of sweets and low intake of fruits were associated with obesity. CONCLUSIONS: Food groups and their combinations that were strongly associated with obesity in Japanese patients with type 2 diabetes were identified. Our findings also suggested an inverse association between the traditional Japanese diet and obesity.

    DOI: 10.3390/nu14153034

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  • 生活習慣・栄養分野におけるガイドライン2022のトピックスと今後の課題 脂質改善・動脈硬化予防のための運動・身体活動

    木庭 新治, 曽根 博仁, 児玉 暁, 藤原 和哉, 横田 裕哉, 宮下 政司, 井上 茂

    日本動脈硬化学会総会プログラム・抄録集   54回   151 - 151   2022年7月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex. 国際誌

    Yasuhiro Matsubayashi, Kazuya Fujihara, Mayuko Yamada-Harada, Yurie Mitsuma, Takaaki Sato, Yuta Yaguchi, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Cardiovascular diabetology   21 ( 1 )   90 - 90   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: To determine the impact of metabolic syndrome (MetS) and/or metabolic dysfunction-associated fatty liver disease (MAFLD), which are pathophysiologically similar and include insulin resistance, on the development of new-onset cardiovascular disease with and without type 2 diabetes and according to sex. METHODS: This study included 570,426 individuals without a history of cardiovascular disease who were enrolled in a nationwide claims database from 2008 to 2016 and were classified by the presence or absence of MetS and/or MAFLD stratified by the presence or absence of type 2 diabetes and sex. The fatty liver index was used to determine the presence or absence of fatty liver that required a diagnosis of MAFLD. Risks of developing coronary artery disease (CAD) and cerebrovascular disease (CVD) in each category were analyzed using a multivariate Cox proportional hazard model. RESULTS: During a median follow-up of 5.2 years, 2252 CAD and 3128 CVD events occurred. Without type 2 diabetes the hazard ratio (HR) (95% CI) for CAD/CVD compared with neither MAFLD nor MetS was 1.32 (1.17-1.50)/1.41(1.28-1.57) for MAFLD only (without MetS), 1.78 (1.22-2.58)/1.66 (1.34-2.06) for MetS only (without MAFLD), and 2.10 (1.84-2.39)/1.73 (1.54-1.95) for MAFLD + MetS. For those with type 2 diabetes, the HR for CAD for MAFLD only (compared with neither MAFLD nor MetS) was 1.29 (1.06-1.58), for MetS only 1.34 (0.84-2.13), and for MAFLD + MetS 1.22 (1.02-1.47). For CVD, there was a significant increase in HR only in MAFLD + MetS [1.44 (1.18-1.76)]. The results of the analysis stratified by sex showed that MAFLD had a greater impact in men, and MetS had a greater impact in women regarding the development of CAD. CONCLUSIONS: Distinguishing between MetS and/or MAFLD in the presence or absence of type 2 diabetes and according to sex may aid in accurately identifying patients at high risk of cardiovascular disease.

    DOI: 10.1186/s12933-022-01518-4

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  • 【健康食品・機能性食品による健康障害の防止】わが国の健康食品やサプリメントによる重篤な有害事象 内科学会症例報告データベースにおける検討

    鈴木 浩史, 渡辺 賢一, 山本 正彦, 武田 安永, 治田 麻理子, 堀川 千嘉, 藤原 和哉, 曽根 博仁

    機能性食品と薬理栄養   15 ( 6 )   297 - 303   2022年6月

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    記述言語:日本語   出版者・発行元:(株)インフォノーツパブリッシング  

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  • J-EDIT・JDCSの合同解析による、年代別に見た日本人2型糖尿病患者の食塩摂取量と心血管疾患発症の縦断的検討

    堀川 千嘉, 池田 和泉, 相田 麗, 田中 司朗, 鎌田 智恵実, 吉村 幸雄, 藤原 和哉, 井藤 英喜, 赤沼 安夫, 守屋 達美, 荒木 厚, 曽根 博仁

    日本栄養・食糧学会大会講演要旨集   76回   231 - 231   2022年5月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • 日本人2型糖尿病患者における食品群摂取量と肥満の関連 JDDMにおける検討

    治田 麻理子, 堀川 千嘉, 武田 安永, 池田 泉, 森川 咲子, 加藤 則子, 加藤 光敏, 横山 宏樹, 栗原 義夫, 前川 聡, 藤原 和哉, 曽根 博仁, 糖尿病データマネジメント研究会

    糖尿病   65 ( Suppl.1 )   S - 131   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 耐糖能およびHDLコレステロール値別にみたLDLコレステロールが冠動脈疾患に及ぼす影響の検討

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴徳, 児玉 暁, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 186   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 小児における睡眠時間およびソーシャルジェットラグと過体重・肥満の関連

    塩崎 悠香, 藤原 和哉, 山田 万祐子, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 山田 貴穂, 曽根 博仁

    日本内分泌学会雑誌   98 ( 1 )   296 - 296   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • HDLコレステロール値別にみたLDLコレステロールと冠動脈疾患との関連

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴穂, 児玉 暁, 曽根 博仁

    日本内分泌学会雑誌   98 ( 1 )   322 - 322   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • AHA Life's simple 7に基づく腎透析導入リスクの予測

    大澤 妙子, 藤原 和哉, 山田 万祐子, 矢口 雄大, 佐藤 隆明, 北澤 勝, 松林 泰弘, 山田 貴穂, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 142   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 新たな総合体力指標を用いたメタボリックシンドロームの発症予測能の検討

    佐藤 隆明, 藤原 和哉, 山田 万祐子, 張 かおり, 矢口 雄大, 山本 正彦, 北澤 勝, 石黒 創, 大澤 妙子, 山田 貴穂, 加藤 公則, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 155   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 青少年におけるスマートフォンを含むスクリーンタイムと肥満との関連

    池田 和泉, 藤原 和哉, 森川 咲子, 武田 安永, 石黒 創, 山田 万祐子, 堀川 千嘉, 松林 泰弘, 山田 貴穂, 曽根 博仁

    日本内分泌学会雑誌   98 ( 1 )   296 - 296   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 妊娠中期における糖代謝状態と低出生体重児出産との関連の検討

    谷内 洋子, 山田 貴穂, 藤原 和哉, 生魚 薫, 堀川 千嘉, 田中 康弘, 龍野 一郎, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 214   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 肥満における各野菜摂取頻度と遺伝子・環境相互作用の検討

    藤原 和哉, 野川 駿, 齋藤 憲司, 堀川 千嘉, 武田 安永, 張 かおり, 石黒 創, 児玉 暁, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 160   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 日本人2型糖尿病患者における、年齢層別に見た食塩摂取量と心血管疾患発症との関係 J-EDIT・JDCSの解析から

    堀川 千嘉, 相田 麗, 田中 司朗, 鎌田 智英実, 田中 佐知子, 吉村 幸雄, 小寺 玲美, 藤原 和哉, 守屋 達美, 井藤 英喜, 赤沼 安夫, 荒木 厚, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 142   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 肥満傾向または肥満を合併した2型糖尿病高リスクを有する男性に対する血糖自己測定SMBGと栄養教育ツールを併用した栄養教育の効果

    長谷川 美代, 堀川 千嘉, 田代 稔, 鈴木 沙織, 藤原 和哉, 北澤 勝, 加藤 公則, 田中 司朗, 曽根 博仁

    日本栄養士会雑誌   65 ( 3 )   159 - 168   2022年3月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養士会  

    肥満傾向または肥満を合併した2型糖尿病高リスク者において、摂取した食事の全体量、食べ方を振り返り、食後血糖との関連を把握できるための栄養教育とSMBGとの併用効果が血糖コントロールやBMIの改善に有効であるかを検討した。対象は、医療機関未受診の20〜69歳男性でHbA1c5.6%以上6.5%未満かつBMI24kg/m2以上の者31人を介入群15人、対照群16人に無作為化クラスター割り付けした。介入群には半年間週2回夕食2時間後にSMBGを行い、食事摂取と食後血糖の関係を認識するよう促し、その間管理栄養士と保健師が3回の栄養教育を実施し、対照群には3回の栄養教育のみ行った。解析条件を満たした者は介入群11人、対照群10人であった。介入群と対照群のHbA1cとBMIは、介入前後の変化量に有意差は認められなかった(p=0.09、0.44)。炭水化物エネルギー比は、介入群のみ介入後の比率が増える傾向にあった(p=0.06)。介入群では、内的誘惑に対する統制感が有意に改善した(p=0.01)。また、「食事量」の行動において介入群、対照群共に有意な改善が見られた(p=0.02、p=0.01)。SMBGと本栄養教育の併用が、1食における3大栄養素や食品群の適量を把握し、「栄養素が血糖に変わる速度と割合」の理解につながること、行動の振り返りと問題点の改善が自己効力感を高め、前向きな行動変容につながることが示唆された。(著者抄録)

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  • Leisure-time physical activity and incidence of objectively assessed hearing loss: The Niigata Wellness Study. 国際誌

    Ryoko Kawakami, Susumu S Sawada, Kiminori Kato, Yuko Gando, Haruki Momma, Hideaki Oike, Motohiko Miyachi, I-Min Lee, Minoru Tashiro, Chika Horikawa, Hajime Ishiguro, Yasuhiro Matsubayashi, Kazuya Fujihara, Hirohito Sone

    Scandinavian journal of medicine & science in sports   32 ( 2 )   435 - 445   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Previous cohort study reported that high physical activity was associated with a low risk of self-reported hearing loss in women. However, no studies have examined the association between physical activity and the development of hearing loss as measured using an objective assessment of hearing loss in men and women. Here, we used cohort data to examine the association between leisure-time physical activity and incidence of objectively assessed hearing loss in men and women. Participants included 27 537 Japanese adults aged 20-80 years without hearing loss, who completed a self-administered physical activity questionnaire between April 2001 and March 2002. The participants were followed up for the development of hearing loss as measured by audiometry between April 2002 and March 2008. During follow-up, 3691 participants developed hearing loss. Compared with the none physical activity group, multivariable adjusted hazard ratios (HRs) for developing hearing loss were 0.93 (95% confidence interval (CI), 0.86-1.01) and 0.87 (0.81-0.95) for the medium (<525 MET-min/week) and high (≥525 MET-min/week) physical activity groups, respectively (p for trend = 0.001). The magnitude of risk reduction was slightly greater in vigorous-intensity activity than in moderate-intensity activity (p for interaction = 0.01). Analysis by sound frequency showed that the amount of physical activity was inversely associated with high frequency hearing loss development (p for trend <0.001), but not with low frequency hearing loss development (p for trend = 0.19). Higher level of leisure-time physical activity was associated with lower incidence of hearing loss, particularly for vigorous-intensity activities and high sound frequencies.

    DOI: 10.1111/sms.14089

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  • Higher Iron Intake Is Independently Associated with Obesity in Younger Japanese Type-2 Diabetes Mellitus Patients. 国際誌

    Efrem d'Ávila Ferreira, Mariko Hatta, Yasunaga Takeda, Chika Horikawa, Mizuki Takeuchi, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Kazuya Fujihara, Hiroshi Maegawa, Hirohito Sone

    Nutrients   14 ( 1 )   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We aimed to analyze the association between dietary iron intake and obesity assessed by BMI after adjustment for nutrient intake (macronutrients and fiber) and food groups. The study design was cross-sectional. Patients with type-2 diabetes (n = 1567; 63.1% males; mean age 62.3 ± 11.6 years) were included in the study. To assess diet, consumption of typical food groups was determined by a food frequency questionnaire. Obesity was defined as BMI ≥ 25 kg/m2. We performed a binary regression analysis between quartiles of iron intake and obesity by quartiles of age group. A direct linear association was found for the highest quartile of iron intake and obesity in the younger age group of 30 to 54 years (OR = 3.641, 95% CI = 1.020-12.990; p trend = 0.011). Multivariate analysis using food groups as opposed to nutrients revealed a positive trend for obesity in the younger age group after adjusting for lifestyle factors, energy intake and bean and vegetable intake (p trend = 0.023). In all participants, an inverse association was observed before adjustment by vegetable intake (OR = 0.453, 95% CI = 0.300-0.684; p trend = 0.001). Higher iron intake was associated with obesity independent of macronutrient and fiber intake but only in the youngest quartile of age group examined.

    DOI: 10.3390/nu14010211

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  • 妊娠中期における母体のインスリン値と低出生体重児出産との関連の検討

    谷内 洋子, 藤原 和哉, 堀川 千嘉, 生魚 薫, 山本 正彦, 石澤 正博, 山田 貴穂, 児玉 暁, 曽根 博仁

    Journal of Epidemiology   32 ( Suppl.1 )   142 - 142   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 耐糖能別おける収縮期血圧と冠動脈疾患(CAD)/脳血管疾患発症(CVD)の関連

    藤原 和哉, 山田 万祐子, 山本 正彦, 松林 泰弘, 北澤 勝, 石澤 正博, 堀川 千嘉, 児玉 暁, 曽根 博仁

    Journal of Epidemiology   32 ( Suppl.1 )   128 - 128   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta-analysis.

    Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Masaru Kitazawa, Midori Iwanaga, Kiminori Kato, Kenichi Watanabe, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Hirohito Sone

    Journal of diabetes investigation   13 ( 5 )   900 - 908   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS/INTRODUCTION: Recently, an increasing number of cohort studies have suggested using machine learning (ML) to predict type 2 diabetes mellitus. However, its predictive ability remains inconclusive. This meta-analysis evaluated the current ability of ML algorithms for predicting incident type 2 diabetes mellitus. MATERIALS AND METHODS: We systematically searched longitudinal studies published from 1 January 1950 to 17 May 2020 using MEDLINE and EMBASE. Included studies had to compare ML's classification with the actual incidence of type 2 diabetes mellitus, and present data on the number of true positives, false positives, true negatives and false negatives. The dataset for these four values was pooled with a hierarchical summary receiver operating characteristic and a bivariate random effects model. RESULTS: There were 12 eligible studies. The pooled sensitivity, specificity, positive likelihood ratio and negative likelihood ratio were 0.81 (95% confidence interval [CI] 0.67-0.90), 0.82 [95% CI 0.74-0.88], 4.55 [95% CI 3.07-6.75] and 0.23 [95% CI 0.13-0.42], respectively. The area under the summarized receiver operating characteristic curve was 0.88 (95% CI 0.85-0.91). CONCLUSIONS: Current ML algorithms have sufficient ability to help clinicians determine whether individuals will develop type 2 diabetes mellitus in the future. However, persons should be cautious before changing their attitude toward future diabetes risk after learning the result of the diabetes prediction test using ML algorithms.

    DOI: 10.1111/jdi.13736

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  • Impact of prior cerebrovascular disease and glucose status on incident cerebrovascular disease in Japanese

    Momoko Oe, Kazuya Fujihara, Mayuko Harada-Yamada, Taeko Osawa, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaaki Sato, Yuta Yaguchi, Midori Iwanaga, Hiroyasu Seida, Takaho Yamada, Hirohito Sone

    Cardiovascular Diabetology   20 ( 1 )   2021年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    <title>Abstract</title><sec>
    <title>Background</title>
    Although both a history of cerebrovascular disease (CVD) and glucose abnormality are risk factors for CVD, few large studies have examined their association with subsequent CVD in the same cohort. Thus, we compared the impact of prior CVD, glucose status, and their combinations on subsequent CVD using real-world data.


    </sec><sec>
    <title>Methods</title>
    This is a retrospective cohort study including 363,627 men aged 18–72 years followed for ≥ 3 years between 2008 and 2016. Participants were classified as normoglycemia, borderline glycemia, or diabetes defined by fasting plasma glucose, HbA1c, and antidiabetic drug prescription. Prior and subsequent CVD (i.e. ischemic stroke, transient ischemic attack, and non-traumatic intracerebral hemorrhage) were identified according to claims using ICD-10 codes, medical procedures, and questionnaires.


    </sec><sec>
    <title>Results</title>
    Participants’ mean age was 46.1 ± 9.3, and median follow up was 5.2 (4.2, 6.7) years. Cox regression analysis showed that prior CVD + conferred excess risk for CVD regardless of glucose status (normoglycemia: hazard ratio (HR), 8.77; 95% CI 6.96–11.05; borderline glycemia: HR, 7.40, 95% CI 5.97–9.17; diabetes: HR, 5.73, 95% CI 4.52–7.25). Compared with normoglycemia, borderline glycemia did not influence risk of CVD, whereas diabetes affected subsequent CVD in those with CVD- (HR, 1.50, 95% CI 1.34–1.68). In CVD-/diabetes, age, current smoking, systolic blood pressure, high-density lipoprotein cholesterol, and HbA1c were associated with risk of CVD, but only systolic blood pressure was related to CVD risk in CVD + /diabetes.


    </sec><sec>
    <title>Conclusions</title>
    Prior CVD had a greater impact on the risk of CVD than glucose tolerance and glycemic control. In participants with diabetes and prior CVD, systolic blood pressure was a stronger risk factor than HbA1c. Individualized treatment strategies should consider glucose tolerance status and prior CVD.


    </sec>

    DOI: 10.1186/s12933-021-01367-7

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    その他リンク: https://link.springer.com/article/10.1186/s12933-021-01367-7/fulltext.html

  • Impact of Medication Adherence and Glycemic Control on the Risk of Micro- and Macrovascular Diseases in Patients with Diabetes. 国際誌

    Yuta Yaguchi, Kazuya Fujihara, Mayuko Harada Yamada, Yasuhiro Matsubayashi, Takaho Yamada, Midori Iwanaga, Masaru Kitazawa, Masahiko Yamamoto, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

    The American journal of medicine   135 ( 4 )   461 - 470   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Our purpose in the research was to clarify the impact of medication adherence to oral hypoglycemic agents during a 1-year period and subsequent glycemic control on the risk of micro- and macrovascular diseases. METHODS: Examined was a nationwide claims database on 13,256 individuals with diabetic eye disease without requiring prior treatment, 7,862 without prior initiation of dialysis, 15,556 without prior coronary artery disease, 16,243 without prior cerebrovascular disease, and 19,386 without prior heart failure from 2008 to 2016 in Japan. Medication adherence was evaluated by the proportion of days covered. Patients were considered to have poor adherence if the proportion of days covered was <80%. Multivariate Cox regression model identified risks of micro- and macrovascular diseases. RESULTS: In each group, mean age was 53 to 54 years, HbA1c was 7.1% to 7.2%, and median follow-up period was 4.6 to 5.1 years, and the percentage of poor adherence was approximately 30%. During the study period, 532 treatment-requiring diabetic eye disease, 75 dialysis, 389 coronary artery disease, 316 cerebrovascular disease, and 144 heart failure events occurred. Multivariate Cox regression model revealed that the hazard ratio (95% confidence interval) of dialysis in the poor adherence group was 2.04 (1.27-3.30) compared with the good adherence group. The hazard ratios in the poor adherence/poor glycemic control group were 3.34 (2.63-4.24) for treatment-requiring diabetic eye disease, 4.23 (2.17-8.26) for dialysis, 1.69 (1.23-2.31) for coronary artery disease, and 2.08 (1.25-3.48) for heart failure compared with the good adherence/good glycemic control group. CONCLUSIONS: Poor medication adherence was an independent risk factor for the initiation of dialysis, suggesting that clinicians must pay close attention to these patients.

    DOI: 10.1016/j.amjmed.2021.10.018

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  • 副腎腫瘍とK低値で内分泌疾患を疑うもGitelman症候群と考えた1例

    中村 博至, 矢口 雄大, 佐藤 孝明, 山本 正彦, 石黒 創, 北澤 勝, 松林 泰弘, 石澤 正博, 鈴木 浩史, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   97 ( 2 )   559 - 559   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711. 国際誌

    Kazuya Fujihara, Shun Nogawa, Kenji Saito, Chika Horikawa, Yasunaga Takeda, Kaori Cho, Hajime Ishiguro, Satoru Kodama, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Hirohito Sone

    Nutrients   13 ( 10 )   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It is unclear whether genetic interactions are involved in the association between vegetable intake and reduced body mass index (BMI) or obesity. We conducted a comprehensive search for single nucleotide polymorphisms (SNPs) which are associated with the interaction between vegetable intake frequency and BMI or obesity. We performed a genome-wide association analysis to evaluate the genetic interactions between self-reported intake of vegetables such as carrot, broccoli, spinach, other green vegetables (green pepper and green beans), pumpkin, and cabbage with BMI and obesity, which is defined as a BMI ≥ 25.0 kg/m2 in the Japanese population (n = 12,225). The mean BMI and prevalence of obesity was 23.9 ± 3.4 kg/m2 and 32.3% in men and 22.1 ± 3.8 kg/m2 and 17.3% in in women, respectively. A significant interaction was observed between rs4445711 and frequency of carrot intake on BMI (p = 4.5 × 10-8). This interaction was slightly attenuated after adjustment for age, sex, alcohol intake, smoking, physical activity and the frequency of total vegetable intake (p = 2.1 × 10-7). A significant interaction was also observed between rs4445711 and frequency of carrot intake on obesity (p = 2.5 × 10-8). No significant interactions that were the same as the interaction between frequency of carrot intake and rs4445711 were observed between the intake frequency of broccoli, spinach, other green vegetables, pumpkin or cabbage and BMI or obesity. The frequency of carrot consumption is implicated in reducing BMI by the intermediary of rs4445711. This novel genetic association may provide new clues to clarify the association between vegetable intake and BMI or obesity.

    DOI: 10.3390/nu13103478

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  • Secular Trends in Dietary Intake over a 20-Year Period in People with Type 2 Diabetes in Japan: A Comparative Study of Two Nationwide Registries; Japan Diabetes Complications Study (JDCS) and Japan Diabetes Clinical Data Management Study (JDDM). 国際誌

    Mizuki Takeuchi, Chika Horikawa, Mariko Hatta, Yasunaga Takeda, Rina Nedachi, Izumi Ikeda, Sakiko Morikawa, Noriko Kato, Hiroki Yokoyama, Rei Aida, Shiro Tanaka, Chiemi Kamada, Yukio Yoshimura, Toshiko Saito, Kazuya Fujihara, Atsushi Araki, Hirohito Sone

    Nutrients   13 ( 10 )   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: In order to provide effective dietary guidance, it is necessary to consider dietary intake, which can change over time. This study analyzed changes in the diet of Japanese patients with type 2 diabetes over a 20-year period. METHODS: We compared the results of two dietary surveys that used the food frequency questionnaire format. The first was conducted in 1996 by the Japan Diabetes Complications Study (JDCS) (n = 1509; males 53.3%), and the second in 2014-2018 by the Japan Diabetes Clinical Data Management Study (JDDM) (n = 1145; males 65.6%). Both are nationwide representative registries of outpatients with type 2 diabetes in Japan. RESULTS: Over a 20-year period, both men and women with type 2 diabetes had a significant increase in body mass index (BMI). Nonetheless, there was only a small change in energy intake. Conversely, there was a significant increase in fat intake and thus in the fat-to-energy ratio. With regard to food groups, there was a significant increase in meat intake and a decrease in the intake of fish, soybeans/soy products, vegetables, and fruits, with a particularly significant decrease in vegetables. CONCLUSIONS: Even in Japan, an industrialized country with a stable socioeconomic environment, there were many significant changes in the dietary intake of patients with type 2 diabetes over the 20-year period.

    DOI: 10.3390/nu13103428

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  • Comparing Associations of Dietary Energy Density and Energy Intake, Macronutrients with Obesity in Patients with Type 2 Diabetes (JDDM 63). 国際誌

    Yasunaga Takeda, Kazuya Fujihara, Rina Nedachi, Izumi Ikeda, Sakiko Yoshizawa Morikawa, Mariko Hatta, Chika Horikawa, Mitsutoshi Kato, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Kazuhiro Miyazawa, Hiroshi Maegawa, Hirohito Sone

    Nutrients   13 ( 9 )   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To investigate the association between dietary energy density (DED) and obesity in people with type 2 diabetes mellitus. Moreover, we compared the strength of the associations of DED with intake of energy and macronutrients in terms of obesity as well as nutritional factors that have long been used for medical nutritional therapy. Cross-sectionally investigated were 1615 outpatients with type 2 diabetes who attended 26 clinics nationwide with diabetes specialists. Odds ratios (ORs) were calculated for the association between obesity and DED, energy, and macronutrients by quintile categories and a 1 SD increment with adjustment for potential confounders. β coefficients were calculated for the association between body mass index (BMI) and each nutritional factor by 1 SD increments in nutritional values. Multi-adjusted OR for obesity between extreme quintiles of DED was 2.99 (95% confidence interval (95% CI): 2.01-3.12). Conversely, the ORs did not differ significantly according to the quintiles of other nutrient factors. Multi-adjusted β coefficient of BMI per 1 SD according to DED was far higher than those of other nutrient factors (β coefficient 0.65, 95% CI: 0.41-0.88). These findings indicated that DED in persons with type 2 diabetes was positively associated with BMI and the prevalence of obesity. DED was also much more potently associated with obesity and BMI than nutritional indicators such as intake of energy or macronutrients.

    DOI: 10.3390/nu13093167

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  • 血清尿酸値と重症糖尿病網膜症との関係

    山本 正彦, 藤原 和哉, 矢口 雄大, 大澤 妙子, 山田 万祐子, 松林 泰弘, 長谷部 日, 山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病合併症   35 ( Suppl. )   268 - 268   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 日本人男性における耐糖能別にみた脳卒中既往がその後の脳卒中発症に与える影響

    山田 万祐子, 藤原 和哉, 大江 桃子, 大澤 妙子, 北澤 勝, 松林 泰弘, 佐藤 隆明, 矢口 雄大, 岩永 みどり, 山田 貴穂, 曽根 博仁

    糖尿病合併症   35 ( Suppl. )   174 - 174   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 経口血糖降下薬(OHA)の服薬アドヒアランスおよび血糖コントロールと細小/大血管合併症発症の関連の検討

    矢口 雄大, 藤原 和哉, 山田 万祐子, 北澤 勝, 山本 正彦, 岩永 みどり, 山田 貴穂, 清田 浩康, 松林 泰弘, 児玉 暁, 曽根 博仁

    糖尿病合併症   35 ( Suppl. )   173 - 173   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • Developing a health economic model for Asians with type 2 diabetes based on the Japan Diabetes Complications Study and the Japanese Elderly Diabetes Intervention Trial. 国際誌

    Shiro Tanaka, Jakob Langer, Tim Morton, Nicki Hoskins, Lars Wilkinson, Sachiko Tanaka-Mizuno, Ryo Kawasaki, Tatsumi Moriya, Chika Horikawa, Rei Aida, Atsushi Araki, Kazuya Fujihara, Hirohito Sone

    BMJ open diabetes research & care   9 ( 1 )   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Cost-effectiveness analyses are becoming increasingly important in Japan following the introduction of a health technology assessment scheme. The study objective was to develop an economic model to evaluate the cost-effectiveness of two interventions for type 2 diabetes in a Japanese population. RESEARCH DESIGN AND METHODS: The Japan Diabetes Complications Study/Japanese Elderly Diabetes Intervention Trial risk engine (JJRE) Cost-Effectiveness Model (JJCEM) was developed, incorporating validated risk equations in Japanese patients with type 2 diabetes from the JJRE. Weibull regression models were developed for progression of the model outcomes, and a targeted literature review was performed to inform default values for utilities and costs. To illustrate outcomes, two simulated analyses were performed in younger (aged 40 years) and older (aged 80 years) Japanese populations, comparing a hypothetical treatment with placebo. RESULTS: The model considers a population based on user-defined values for 11 baseline characteristic parameters and simulates rates of diabetic complications over a defined time horizon. Costs, quality-adjusted life years, and an incremental cost-effectiveness ratio are estimated. The model provides disaggregated results for two competing interventions, allowing visualization of the key drivers of cost and utility. A scatterplot of simulations and cost-effectiveness acceptability curve are generated for each analysis. CONCLUSIONS: This is the first cost-effectiveness model for East Asian patients with type 2 diabetes, developed using Japan-specific risk equations. This population constitutes the largest share of the global population with diabetes, making this model highly relevant. The model can be used to evaluate the cost-effectiveness of anti-diabetic interventions in patients with type 2 diabetes in Japan and other East Asian populations.

    DOI: 10.1136/bmjdrc-2021-002177

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  • 認知機能低下/治療中断による2型糖尿病の血糖増悪が急性発症1型糖尿病であった1例

    村井 幸四郎, 金子 正儀, 岸 裕太郎, 今西 明, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    糖尿病   64 ( 7 )   425 - 425   2021年7月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 日本人2型糖尿病患者における野菜・果物摂取量の組合せと肥満リスク

    竹内 瑞希, 堀川 千嘉, 治田 麻理子, 武田 安永, 加藤 則子, 前川 聡, 斎藤 トシ子, 藤原 和哉, 曽根 博仁

    日本栄養・食糧学会大会講演要旨集   75回   145 - 145   2021年7月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • Associations of Systolic Blood Pressure and Diastolic Blood Pressure With the Incidence of Coronary Artery Disease or Cerebrovascular Disease According to Glucose Status

    Mayuko Harada Yamada, Kazuya Fujihara, Satoru Kodama, Takaaki Sato, Taeko Osawa, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Wataru Ogawa, Hirohito Sone

    Diabetes Care   dc202252 - dc202252   2021年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association  

    DOI: 10.2337/dc20-2252

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  • Accuracy of Japanese claims data in identifying diabetes-related complications. 国際誌

    Kazuya Fujihara, Mayuko Yamada-Harada, Yasuhiro Matsubayashi, Masaru Kitazawa, Masahiko Yamamoto, Yuta Yaguchi, Hiroyasu Seida, Satoru Kodama, Kohei Akazawa, Hirohito Sone

    Pharmacoepidemiology and drug safety   30 ( 5 )   594 - 601   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To evaluate the accuracy of various claims-based definitions of diabetes-related complications (coronary artery disease [CAD], heart failure, cerebrovascular disease and dialysis). METHODS: We evaluated data on 1379 inpatients who received care at the Niigata University Medical & Dental Hospital in September 2018. Manual electronic medical chart reviews were conducted for all patients with regard to diabetes-related complications and were used as the gold standard. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of each claims-based definition associated with diabetes-related complications based on Diagnosis Procedure Combination (DPC), International Classification of Diseases, Tenth Revision (ICD-10) codes, procedure codes and medication codes were calculated. RESULTS: DPC-based definitions had higher sensitivity, specificity, and PPV than ICD-10 code definitions for CAD and cerebrovascular disease, with sensitivity of 0.963-1.000 and 0.905-0.952, specificity of 1.000 and 1.000, and PPV of 1.000 and 1.000, respectively. Sensitivity, specificity, and PPV were high using procedure codes for CAD and dialysis, with sensitivity of 0.963 and 1.000, specificity of 1.000 and 1.000, and PPV of 1.000 and 1.000, respectively. DPC and/or ICD-10 codes + medication were better for heart failure than the ICD-10 code definition, with sensitivity of 0.933, specificity of 1.000, and PPV of 1.000. The PPVs were lower than 60% for all diabetes-related complications using ICD-10 codes only. CONCLUSION: The DPC-based definitions for CAD and cerebrovascular disease, procedure codes for CAD and dialysis, and DPC or ICD-10 codes with medication codes for heart failure could accurately identify these diabetes-related complications from claims databases.

    DOI: 10.1002/pds.5213

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  • 糖尿病(DM)の有無別にみたeGFRと尿蛋白が透析開始に及ぼす影響

    大澤 妙子, 藤原 和哉, 山田 万祐子, 山本 正彦, 矢口 雄大, 北澤 勝, 松林 泰弘, 山田 貴穂, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   I - 8   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 服薬アドヒアランスと下肢切断のリスクに関する縦断的検討(第2報)

    金子 正儀, 藤原 和哉, 山田 万祐子, 北澤 勝, 矢口 雄大, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   P - 4   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病の悪化と視野障害により再発が疑われたCushing病

    今西 明, 北川 めぐみ, 渡辺 聖央, 小松 健, 北澤 優, 松林 泰弘, 岡田 正康, 山田 貴穂, 藤原 和哉, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   P - 1   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 健診の体力テスト結果を用いた総合体力指標の算出と生活習慣病との関連の検討

    佐藤 隆明, 藤原 和哉, 矢口 雄大, 山田 万祐子, 北澤 勝, 山本 正彦, 松林 泰弘, 岩永 みどり, 山田 貴穂, 加藤 公則, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   III - 1   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 機械学習による糖尿病専門医のインスリン選択の予測能の検討及び一般医との比較検討

    藤原 和哉, 松林 泰弘, 山田 万祐子, 山本 正彦, 飯塚 敏浩, 宮村 幸祐, 長谷川 好範, 山本 寛悟, 前川 聡, 山崎 達也, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   III - 3   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • SGLT2阻害薬投与早期及び慢性期のヘモグロビン変化予測因子の検討 貧血・多血例における評価

    松林 泰弘, 吉田 明弘, 菅波 秀規, 矢口 雄大, 山本 正彦, 石黒 創, 北澤 勝, 岩永 みどり, 山田 貴穂, 藤原 和哉, 加来 浩平, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   II - 1   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 経口血糖降下薬(OHA)の服薬アドヒアランス(Ad)と生活習慣因子の関連

    矢口 雄大, 藤原 和哉, 山田 万祐子, 北澤 勝, 金子 正儀, 清田 浩康, 松林 泰弘, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   III - 1   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 日本人男性における耐糖能と脳卒中既往がその後の脳卒中発症に与える影響 リアルワールドデータによる検討

    山田 万祐子, 藤原 和哉, 大江 桃子, 大澤 妙子, 北澤 勝, 松林 泰弘, 佐藤 隆明, 矢口 雄大, 岩永 みどり, 清田 浩康, 山田 貴穂, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   III - 2   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • これからの糖尿病食事療法における課題と展望 大規模データサイエンスから見た新食事ガイドラインに残された課題と解決案 患者さんと指導現場の疑問に答えるには

    曽根 博仁, 堀川 千嘉, 藤原 和哉, 前川 聡, 荒木 厚, JDCSグループ, J-EDITグループ, JDDMグループ

    糖尿病   64 ( Suppl.1 )   S22 - 5   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • メトホルミン内服中の2型糖尿病患者に対するDPP4阻害薬またはSGLT2阻害薬の追加併用効果の多施設共同無作為化比較試験

    北澤 勝, 片桐 尚, 鈴木 裕美, 松永 佐澄志, 山田 万祐子, 五十嵐 智雄, 山本 正彦, 古川 和郎, 岩永 みどり, 治田 麻理子, 藤原 和哉, 山田 貴穂, 田中 司郎, 曽根 博仁, NISM研究グループ

    糖尿病   64 ( Suppl.1 )   I - 6   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database. 国際誌

    Masanori Kaneko, Kazuya Fujihara, Mayuko Yamada Harada, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

    Journal of foot and ankle research   14 ( 1 )   29 - 29   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The prevalence of diabetes is rising, and diabetes develops at a younger age in East Asia. Although lower limb amputation negatively affects quality of life and increases the risk of cardiovascular events, little is known about the rates and predictors of amputation among persons with diabetes from young adults to those in the "young-old" category (50-72 y). METHODS: We analyzed data from a nationwide claims database in Japan accumulated from 2008 to 2016 involving 17,288 people with diabetes aged 18-72 y (mean age 50.2 y, HbA1c 7.2%). Amputation occurrence was determined according to information from the claims database. Cox regression model identified variables related to lower limb amputation. RESULTS: The mean follow-up time was 5.3 years, during which time 16 amputations occurred (0.17/1000 person-years). Multivariate Cox regression analysis showed that age (hazard ratio [HR] 1.09 [95% confidence intervals] 1.02-1.16, p = 0.01) and HbA1c (HR 1.46 [1.17-1.81], p < 0.01) were independently associated with amputations. Compared with those aged < 60 years with HbA1c < 8.0%, the HR for amputation was 27.81 (6.54-118.23) in those aged ≥60 years and HbA1c ≥8.0%. CONCLUSIONS: Age and HbA1c were associated with amputations among diabetic individuals, and the rates of amputation were significantly greater in those ≥60 years old and with HbA1c ≥8.0%.

    DOI: 10.1186/s13047-021-00474-8

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  • 心血管疾患既往の有無と耐糖能状態別に見たその後の心血管疾患発症リスク

    北澤 勝, 藤原 和哉, 山田 万祐子, 大澤 妙子, 矢口 雄大, 山本 正彦, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    日本内分泌学会雑誌   97 ( 1 )   274 - 274   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • ソマトスタチン受容体シンチグラフィが診断に有用であった肺カルチノイドによる周期性ACTH依存性クッシング症候群の1例

    金子 正儀, 佐藤 隆明, 福武 嶺一, 滝澤 祥子, 今西 明, 安楽 匠, 小松 健, 北澤 勝, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   97 ( 1 )   363 - 363   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • ソマトスタチン受容体シンチグラフィが診断に有用であった肺カルチノイドによる周期性ACTH依存性クッシング症候群の1例

    金子 正儀, 佐藤 隆明, 福武 嶺一, 滝澤 祥子, 今西 明, 安楽 匠, 小松 健, 北澤 勝, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   97 ( 1 )   363 - 363   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 心血管疾患既往の有無と耐糖能状態別に見たその後の心血管疾患発症リスク

    北澤 勝, 藤原 和哉, 山田 万祐子, 大澤 妙子, 矢口 雄大, 山本 正彦, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    日本内分泌学会雑誌   97 ( 1 )   274 - 274   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Association of estimated plasma volume and weight loss after long-term administration and subsequent discontinuation of the SGLT2 inhibitor, tofogliflozin. 国際誌

    Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone

    Diabetes, obesity & metabolism   23 ( 7 )   1660 - 1665   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Sodium/glucose-cotransporter 2 inhibitors (SGLT2is) are drugs that have been reported to have several effects through the regulation of plasma volume such as antihypertensive effects, etc. This study aimed to clarify the impact of long-term administration and subsequent discontinuation of the SGLT2i tofogliflozin on estimated plasma volume (ePV), brain natriuretic peptide (BNP) and the relationship between changes in ePV, BNP and body weight (BW). Data from 157 participants with type 2 diabetes receiving tofogliflozin monotherapy in a phase 3 study were analyzed. Changes in variables or correlations among them during a 52-week administration and 2-week post-treatment period were investigated. Percent change in ePV was calculated by the Strauss Formula. Significant decreases in BW, ePV and ln-transformed BNP (ln-BNP) were noted by week 52. %ΔBW was not significantly correlated with %ΔePV and Δln-BNP while %ΔePV was significantly correlated with Δln-BNP. Two weeks after discontinuation of tofogliflozin, BW, ePV and ln-BNP were significantly increased. %ΔBW was significantly correlated with %ΔePV and Δln-BNP. Furthermore, ePV and BNP were significantly higher than baseline levels. This article is protected by copyright. All rights reserved.

    DOI: 10.1111/dom.14387

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  • Author Correction: Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure. 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Mariko Hatta, Yasunaga Takeda, Rena Nedachi, Kiminori Kato, Kenichi Watanabe, Hirohito Sone

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 7 )   894 - 894   2021年3月

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  • The DPP-4 inhibitor, anagliptin, alters hepatic insulin clearance in relation to the glycemic status in Japanese individuals with type 2 diabetes.

    Takahiro Abe, Yasuhiro Matsubayashi, Sayaka Muragishi, Akihiro Yoshida, Hideki Suganami, Kenichi Furusawa, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

    Journal of diabetes investigation   12 ( 10 )   1805 - 1815   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS/INTRODUCTION: This study investigated the impact of the DPP-4 inhibitor, anagliptin, on hepatic insulin clearance (HIC) in Japanese type 2 diabetes patients and explored its relation to glycemic status. MATERIALS AND METHODS: Data on 765 participants in anagliptin phase 2 and 3 studies were analyzed. Adjusted changes in variables during 12 weeks of anagliptin therapy were compared with placebo. HIC was calculated as the ratio, c-peptide area under the curve (AUC)0-120min to insulin AUC0-120min, after a meal tolerance test. To explore the effects of baseline HIC levels on variables, participants receiving anagliptin were divided according to quartiles of baseline HIC. Further, multivariate analysis investigated the association between baseline HIC levels and glycemic status. RESULTS: Anagliptin significantly reduced HbA1c levels (p<0.001 vs. placebo) and HIC levels (p<0.01). Longer duration of diabetes, lower BMI, higher HbA1c and lower insulin secretion capacity were observed with increases in baseline HIC levels. Improvements in HbA1c, glycoalbumin and 1,5-anhydroglucitol levels were greater in the relatively higher HIC group (baseline HIC levels ≥ median) than in the lower HIC group (<median). CONCLUSIONS: Anagliptin affected HIC levels according to HIC baseline levels. Higher baseline HIC values may result in improved hyperglycemia through reduced HIC.

    DOI: 10.1111/jdi.13543

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  • Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure. 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Mariko Hatta, Yasunaga Takeda, Rena Nedachi, Kiminori Kato, Kenichi Watanabe, Hirohito Sone

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 7 )   885 - 887   2021年3月

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  • Body flexibility and incident hypertension: The Niigata wellness study. 国際誌

    Yuko Gando, Susumu S Sawada, Haruki Momma, Ryoko Kawakami, Motohiko Miyachi, I-Min Lee, Steven N Blair, Minoru Tashiro, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Kazuya Fujihara, Kiminori Kato, Hirohito Sone

    Scandinavian journal of medicine & science in sports   31 ( 3 )   702 - 709   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A high level of physical fitness, especially cardiorespiratory fitness, is associated with lower incidence of hypertension. However, the relationship between flexibility, which is a component of physical fitness, and the incidence of hypertension is unknown. The purpose of this study was to investigate the relationship between flexibility and the incidence of hypertension in a cohort study. A total of 22,972 (14,805 men and 8167 women; median age 49 years) normotensive participants were included in this study. Between April 2001 and March 2002, flexibility (standing forward bending) was measured using a standing trunk flexion meter. The participants were divided into quartiles of flexibility by sex and age group. Hypertension was defined as systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg, or a self-reported history of previously diagnosed hypertension or current medication for hypertension at a health examination between April 2002 and March 2008. Hazard ratios and 95% confidence intervals (95% CI) for the incidence of hypertension were estimated using Cox proportional hazards models after adjusting for age, sex, body mass index, exercise habits, smoking status, and drinking status. During 102,948 person years of follow-up (median 5.6 years), 4235 participants developed hypertension. Compared with the lowest flexibility (quartile 1), hazard ratios and 95% CI were 0.96 (0.88 - 1.04) for quartile 2, 0.94 (0.86 - 1.03) for quartile 3, and 0.83 (0.76 - 0.91) for quartile 4. A high level of flexibility was associated with lower incidence of hypertension, independent of other confounding factors.

    DOI: 10.1111/sms.13867

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  • Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus. 国際誌

    Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Hiroyasu Seida, Satoru Kodama, Yoshimi Nakagawa, Hitoshi Shimano, Hirohito Sone

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research   69 ( 3 )   724 - 729   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To determine associations between severity of hypertension and risk of starting dialysis in the presence or absence of diabetes mellitus (DM). A nationwide database with claims data on 258 874 people with and without DM aged 19-72 years in Japan was used to elucidate the impact of severity of hypertension on starting dialysis. Initiation of dialysis was determined from claims using International Classification of Diseases-10 codes and medical procedures. Using multivariate Cox modeling, we investigated the severity of hypertension to predict the initiation of dialysis with and without DM. Hypertension was significantly associated with the initiation of dialysis regardless of DM. The incidence of starting dialysis in those with systolic blood pressure (SBP) ≤119 mm Hg and DM (DM+) was almost the same as in those with SBP ≥150 mm Hg and absence of DM (DM-). In comparison with SBP ≤119 mm Hg, SBP ≥150 mm Hg significantly increased the risk of the initiation of dialysis about 2.5 times regardless of DM+ or DM-. Compared with DM- and SBP ≤119 mm Hg, the HR for DM+ and SBP ≥150 mm Hg was 6.88 (95% CI 3.66 to 12.9). Although the risks of hypertension differed only slightly regardless of the presence or absence of DM, risks for starting dialysis with DM+ and SBP ≤119 mm Hg were equivalent to DM- and SBP ≥150 mm Hg, indicating more strict blood pressure interventions in DM+ are needed to avoid dialysis. Future studies are required to clarify the cut-off SBP level to avoid initiation of dialysis considering the risks of strict control of blood pressure.

    DOI: 10.1136/jim-2020-001489

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  • A 52-week randomized controlled trial of ipragliflozin or sitagliptin in type 2 diabetes combined with metformin: The N-ISM study. 国際誌

    Masaru Kitazawa, Takashi Katagiri, Hiromi Suzuki, Satoshi Matsunaga, Mayuko H Yamada, Tomoo Ikarashi, Masahiko Yamamoto, Kazuo Furukawa, Midori Iwanaga, Mariko Hatta, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Hirohito Sone

    Diabetes, obesity & metabolism   23 ( 3 )   811 - 821   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: To compare the long-term efficacy of sodium-glucose co-transporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors as second-line drugs after metformin for patients not at high risk of atherosclerotic cardiovascular disease (ASCVD). MATERIALS AND METHODS: In a 52-week randomized open-label trial, we compared ipragliflozin and sitagliptin in Japanese patients diagnosed with type 2 diabetes, without prior ASCVD and treated with metformin. The primary endpoint was a glycated haemoglobin (HbA1c) reduction of ≥0.5% (5.5 mmol/mol) without weight gain at 52 weeks. RESULTS: Of a total of 111 patients (mean age 59.2 years, mean body mass index [BMI] 26.6 kg/m2 , 61.3% men), 54 patients received ipragliflozin and 57 received sitagliptin. After 52 weeks, achievement of the primary endpoint was not significantly different (37.0% and 40.3%; P = 0.72). HbA1c reduction rate at 24 weeks was greater for sitagliptin (56.1%) than for ipragliflozin (31.5%; P = 0.01). From 24 to 52 weeks, the HbA1c reduction with sitagliptin was attenuated, with no significant difference in HbA1c reduction after 52 weeks between sitagliptin (54.4%) and ipragliflozin (38.9%; P = 0.10). Improvements in BMI, C-peptide and high-density lipoprotein cholesterol were greater with ipragliflozin than with sitagliptin. Adverse events occurred in 17 patients with ipragliflozin and in 10 patients with sitagliptin (P = 0.11). CONCLUSION: The HbA1c-lowering effect at 24 weeks was greater with sitagliptin than with ipragliflozin, but with no difference in efficacy related to HbA1c and body weight at 52 weeks. However, some ASCVD risk factors improved with ipragliflozin.

    DOI: 10.1111/dom.14288

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  • 特定保健指導の最適介入法の同定を目指した前向き研究 新潟方式の試作とそのパイロットスタディによる効果の評価

    加藤 公則, 田代 稔, 鈴木 沙織, 大塚 政人, 小林 隆司, 三木 扶久子, 春木 匠, 小松原 祐介, 藤原 和哉, 津下 一代, 赤澤 宏平, 曽根 博仁

    人間ドック   35 ( 5 )   704 - 712   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

    目的:2018年度より特定健診・特定保健指導も第3期を迎え、「柔軟な運用による特定保健指導のモデル実施(以下モデル実施と略す)」が設けられた。このモデル実施を用いた新たな特定保健指導「新潟方式」を確立するために、現状の保健指導180ポイントにおいて、その効果に有効下限閾値があるのかを検証した。方法:対象は、2018年4月から12月までに特定健診を受けた人で、特定保健指導の積極的支援の対象者202人、A群0ポイント、B群20ポイント、C群100ポイント、D群180ポイントの4群に分け、保健指導終了の3ヵ月後の実績評価時に、腹囲2.0cm以上かつ体重2.0kg以上相当に減少した者(達成者)の割合を群間比較し、有効下限閾値の有無を検討した。また翌年の特定健診データとも比較検討し、その特定保健指導効果の持続性も確認した。結果:実績評価時の達成者の割合については、A群20.4%、B群36.0%、C群28.0%、D群12.5%であり、BとD群間のみ有意差が認められた。実績評価時の達成者が翌年も達成者のままでいた人はA群80.0%、B群88.9%、C群92.3%、D群100%であり、群間に有意差はなかった。結論:実績評価時において、保健指導の効果にはポイント数に依存する関係は存在せず、有効下限閾値は存在しなかった。また、翌年も特定保健指導の効果が持続していた。(著者抄録)

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  • 特定保健指導の最適介入法の同定を目指した前向き研究 新潟方式の試作とそのパイロットスタディによる効果の評価

    加藤 公則, 田代 稔, 鈴木 沙織, 大塚 政人, 小林 隆司, 三木 扶久子, 春木 匠, 小松原 祐介, 藤原 和哉, 津下 一代, 赤澤 宏平, 曽根 博仁

    人間ドック   35 ( 5 )   704 - 712   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

    目的:2018年度より特定健診・特定保健指導も第3期を迎え、「柔軟な運用による特定保健指導のモデル実施(以下モデル実施と略す)」が設けられた。このモデル実施を用いた新たな特定保健指導「新潟方式」を確立するために、現状の保健指導180ポイントにおいて、その効果に有効下限閾値があるのかを検証した。方法:対象は、2018年4月から12月までに特定健診を受けた人で、特定保健指導の積極的支援の対象者202人、A群0ポイント、B群20ポイント、C群100ポイント、D群180ポイントの4群に分け、保健指導終了の3ヵ月後の実績評価時に、腹囲2.0cm以上かつ体重2.0kg以上相当に減少した者(達成者)の割合を群間比較し、有効下限閾値の有無を検討した。また翌年の特定健診データとも比較検討し、その特定保健指導効果の持続性も確認した。結果:実績評価時の達成者の割合については、A群20.4%、B群36.0%、C群28.0%、D群12.5%であり、BとD群間のみ有意差が認められた。実績評価時の達成者が翌年も達成者のままでいた人はA群80.0%、B群88.9%、C群92.3%、D群100%であり、群間に有意差はなかった。結論:実績評価時において、保健指導の効果にはポイント数に依存する関係は存在せず、有効下限閾値は存在しなかった。また、翌年も特定保健指導の効果が持続していた。(著者抄録)

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  • Sodium Intake and Incidence of Diabetes Complications in Elderly Patients with Type 2 Diabetes-Analysis of Data from the Japanese Elderly Diabetes Intervention Study (J-EDIT). 国際誌

    Chika Horikawa, Rei Aida, Shiro Tanaka, Chiemi Kamada, Sachiko Tanaka, Yukio Yoshimura, Remi Kodera, Kazuya Fujihara, Ryo Kawasaki, Tatsumi Moriya, Hidetoshi Yamashita, Hideki Ito, Hirohito Sone, Atsushi Araki

    Nutrients   13 ( 2 )   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study investigates the associations between sodium intake and diabetes complications in a nationwide cohort of elderly Japanese patients with type 2 diabetes aged 65-85. Data from 912 individuals regarding their dietary intake at baseline is analyzed and assessed by the Food Frequency Questionnaire based on food groups. Primary outcomes are times to diabetic retinopathy, overt nephropathy, cardiovascular disease (CVD), and all-cause mortality during six years. We find that mean sodium intake in quartiles ranges from 2.5 g to 5.9 g/day. After adjustment for confounders, no significant associations are observed between sodium intake quartiles and incidence of diabetes complications and mortality, except for a significant trend for an increased risk of diabetic retinopathy (p = 0.039). Among patients whose vegetable intake was less than the average of 268.7 g, hazard ratios (HRs) for diabetic retinopathy in patients in the second, third, and fourth quartiles of sodium intake compared with the first quartile were 0.87 (95% CI, 0.31-2.41), 2.61 (1.00-6.83), and 3.70 (1.37-10.02), respectively. Findings indicate that high sodium intake under conditions of low vegetable intake is associated with an elevated incidence of diabetic retinopathy in elderly patients with type 2 diabetes.

    DOI: 10.3390/nu13020689

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  • A Prospective Cohort Study of Muscular and Performance Fitness and Risk of Hearing Loss: The Niigata Wellness Study. 査読 国際誌

    Ryoko Kawakami, Susumu S Sawada, Kiminori Kato, Yuko Gando, Haruki Momma, Hideaki Oike, Motohiko Miyachi, I-Min Lee, Steven N Blair, Minoru Tashiro, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Kazuya Fujihara, Hirohito Sone

    The American journal of medicine   134 ( 2 )   235 - 242   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Several cross-sectional studies have linked higher physical fitness with better hearing sensitivity but have not established a causal relation; none have used a prospective design that is less susceptible to bias. We used a prospective cohort study to investigate the association between muscular and performance fitness and the incidence of hearing loss. METHODS: A total of 21,907 participants without hearing loss received physical fitness assessments between April 2001 and March 2002. Muscular and performance fitness index, an age- and sex-specific summed z-score based on grip strength, vertical jump height, single-leg balance, forward bending, and whole-body reaction time was calculated. Participants were classified into quartiles according to the muscular and performance fitness index and each physical fitness test. They were followed up for the development of hearing loss, assessed by pure-tone audiometry at annual health examinations between April 2002 and March 2008. Hazard ratios and 95% confidence intervals for hearing loss incidence were estimated using Cox proportional hazards regression models. RESULTS: During follow-up, 2765 participants developed hearing loss. The hazard ratios (95% confidence intervals) for developing hearing loss across the muscular and performance fitness index quartiles (lowest to highest) were 1.00 (reference), 0.88 (0.79-0.97), 0.83 (0.75-0.93), and 0.79 (0.71-0.88) (Ptrend <.001). Among the various physical fitness components, a clear dose-response association with hearing loss incidence was observed for vertical jump height and single-leg balance (Ptrend <.001 for both). CONCLUSION: Higher muscular and performance fitness is associated with a lower incidence of hearing loss.

    DOI: 10.1016/j.amjmed.2020.06.021

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  • 糖尿病患者におけるIoT端末による食事運動記録と持続血糖測定器を用いた新しい食事運動療法の開発

    北澤 勝, 藤原 和哉, 石澤 正博, 松林 泰弘, 山田 貴穂, 曽根 博仁

    新潟県医師会報   ( 851 )   10 - 11   2021年2月

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    記述言語:日本語   出版者・発行元:新潟県医師会  

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  • メタ解析的アプローチによる塩分摂取と心不全発症リスクとの量-反応分析

    児玉 暁, 藤原 和哉, 渡辺 賢一, 加藤 公則, 曽根 博仁

    日本内科学会雑誌   110 ( Suppl. )   142 - 142   2021年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • Ability of Current Machine Learning Algorithms to Predict and Detect Hypoglycemia in Patients With Diabetes Mellitus: Meta-analysis. 国際誌

    Satoru Kodama, Kazuya Fujihara, Haruka Shiozaki, Chika Horikawa, Mayuko Harada Yamada, Takaaki Sato, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Midori Iwanaga, Yasuhiro Matsubayashi, Hirohito Sone

    JMIR diabetes   6 ( 1 )   e22458   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Machine learning (ML) algorithms have been widely introduced to diabetes research including those for the identification of hypoglycemia. OBJECTIVE: The objective of this meta-analysis is to assess the current ability of ML algorithms to detect hypoglycemia (ie, alert to hypoglycemia coinciding with its symptoms) or predict hypoglycemia (ie, alert to hypoglycemia before its symptoms have occurred). METHODS: Electronic literature searches (from January 1, 1950, to September 14, 2020) were conducted using the Dialog platform that covers 96 databases of peer-reviewed literature. Included studies had to train the ML algorithm in order to build a model to detect or predict hypoglycemia and test its performance. The set of 2 × 2 data (ie, number of true positives, false positives, true negatives, and false negatives) was pooled with a hierarchical summary receiver operating characteristic model. RESULTS: A total of 33 studies (14 studies for detecting hypoglycemia and 19 studies for predicting hypoglycemia) were eligible. For detection of hypoglycemia, pooled estimates (95% CI) of sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were 0.79 (0.75-0.83), 0.80 (0.64-0.91), 8.05 (4.79-13.51), and 0.18 (0.12-0.27), respectively. For prediction of hypoglycemia, pooled estimates (95% CI) were 0.80 (0.72-0.86) for sensitivity, 0.92 (0.87-0.96) for specificity, 10.42 (5.82-18.65) for PLR, and 0.22 (0.15-0.31) for NLR. CONCLUSIONS: Current ML algorithms have insufficient ability to detect ongoing hypoglycemia and considerate ability to predict impeding hypoglycemia in patients with diabetes mellitus using hypoglycemic drugs with regard to diagnostic tests in accordance with the Users' Guide to Medical Literature (PLR should be ≥5 and NLR should be ≤0.2 for moderate reliability). However, it should be emphasized that the clinical applicability of these ML algorithms should be evaluated according to patients' risk profiles such as for hypoglycemia and its associated complications (eg, arrhythmia, neuroglycopenia) as well as the average ability of the ML algorithms. Continued research is required to develop more accurate ML algorithms than those that currently exist and to enhance the feasibility of applying ML in clinical settings. TRIAL REGISTRATION: PROSPERO International Prospective Register of Systematic Reviews CRD42020163682; http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42020163682.

    DOI: 10.2196/22458

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  • Machine Learning Approach to Decision Making for Insulin Initiation in Japanese Patients With Type 2 Diabetes (JDDM 58): Model Development and Validation Study. 国際誌

    Kazuya Fujihara, Yasuhiro Matsubayashi, Mayuko Harada Yamada, Masahiko Yamamoto, Toshihiro Iizuka, Kosuke Miyamura, Yoshinori Hasegawa, Hiroshi Maegawa, Satoru Kodama, Tatsuya Yamazaki, Hirohito Sone

    JMIR medical informatics   9 ( 1 )   e22148   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Applications of machine learning for the early detection of diseases for which a clear-cut diagnostic gold standard exists have been evaluated. However, little is known about the usefulness of machine learning approaches in the decision-making process for decisions such as insulin initiation by diabetes specialists for which no absolute standards exist in clinical settings. OBJECTIVE: The objectives of this study were to examine the ability of machine learning models to predict insulin initiation by specialists and whether the machine learning approach could support decision making by general physicians for insulin initiation in patients with type 2 diabetes. METHODS: Data from patients prescribed hypoglycemic agents from December 2009 to March 2015 were extracted from diabetes specialists' registries, resulting in a sample size of 4860 patients who had received initial monotherapy with either insulin (n=293) or noninsulin (n=4567). Neural network output was insulin initiation ranging from 0 to 1 with a cutoff of >0.5 for the dichotomous classification. Accuracy, recall, and area under the receiver operating characteristic curve (AUC) were calculated to compare the ability of machine learning models to make decisions regarding insulin initiation to the decision-making ability of logistic regression and general physicians. By comparing the decision-making ability of machine learning and logistic regression to that of general physicians, 7 cases were chosen based on patient information as the gold standard based on the agreement of 8 of the 9 specialists. RESULTS: The AUCs, accuracy, and recall of logistic regression were higher than those of machine learning (AUCs of 0.89-0.90 for logistic regression versus 0.67-0.74 for machine learning). When the examination was limited to cases receiving insulin, discrimination by machine learning was similar to that of logistic regression analysis (recall of 0.05-0.68 for logistic regression versus 0.11-0.52 for machine learning). Accuracies of logistic regression, a machine learning model (downsampling ratio of 1:8), and general physicians were 0.80, 0.70, and 0.66, respectively, for 43 randomly selected cases. For the 7 gold standard cases, the accuracies of logistic regression and the machine learning model were 1.00 and 0.86, respectively, with a downsampling ratio of 1:8, which were higher than the accuracy of general physicians (ie, 0.43). CONCLUSIONS: Although we found no superior performance of machine learning over logistic regression, machine learning had higher accuracy in prediction of insulin initiation than general physicians, defined by diabetes specialists' choice of the gold standard. Further study is needed before the use of machine learning-based decision support systems for insulin initiation can be incorporated into clinical practice.

    DOI: 10.2196/22148

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  • 糖尿病と定期的な運動習慣が要介護発症へ及ぼす影響の検討

    藤原 和哉, 山田 万祐子, 北澤 勝, 松林 泰弘, 八尋 拓也, 筒井 歩, 加藤 公則, 曽根 博仁

    Journal of Epidemiology   31 ( Suppl. )   102 - 102   2021年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • Skipping breakfast, late-night eating and current smoking are associated with medication adherence in Japanese patients with diabetes. 査読 国際誌

    Yuta Yaguchi, Kazuya Fujihara, Mayuko Harada Yamada, Yasuhiro Matsubayashi, Masaru Kitazawa, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Nauta Yamanaka, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

    Primary care diabetes   14 ( 6 )   753 - 759   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Little is known about the relationship between medication adherence for oral hypoglycemic agents (OHAs) and glycemic control after adjusting healthy adherer effect in large scale study. Thus, adjusting for health-related behaviors, we investigated the clinical variables associated with medication adherence and the relationship between medication adherence and glycemic control using a large claims database. METHODS: Analyzed were 8805 patients with diabetes whose medication records for OHA were available for at least 1year. Medication adherence was evaluated by the proportion of days covered (PDC). Multivariate logistic regression model was used to identify clinical variables significantly associated with non-adherence. Multiple regression analysis evaluated the relationship between PDC and HbA1c after adjusting for health-related behaviors. RESULTS: Mean PDC was 80.1% and 32.8% of patients were non-adherence. Logistic analysis indicated that older age and taking concomitant medications were significantly associated with adherence while skipping breakfast (odds ratio 0.66 [95% CI 0.57-0.76]), late-night eating (0.86 [0.75-0.98]), and current smoking (0.89 [0.80-0.99]) were significantly associated with non-adherence. CONCLUSIONS: Skipping breakfast, late-night eating and current smoking were significantly associated with medication adherence, suggesting that clinicians pay attention to those health-related behaviors to achieve good medication adherence.

    DOI: 10.1016/j.pcd.2020.05.002

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  • 心血管・動脈硬化 耐糖能別にみた収縮期血圧と冠動脈疾患、脳血管疾患発症との関連

    山田 万祐子, 藤原 和哉, 大澤 妙子, 矢口 雄大, 北澤 勝, 松林 泰弘, 岩永 みどり, 清田 浩康, 山中 菜詩, 山田 貴穂, 曽根 博仁

    糖尿病合併症   34 ( Suppl.1 )   219 - 219   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 眼科処置を要する糖尿病重症眼疾患発生と飲酒についての検討

    山本 正彦, 藤原 和哉, 矢口 雄大, 大澤 妙子, 山田 万祐子, 松林 泰弘, 長谷部 日, 曽根 博仁

    糖尿病合併症   34 ( Suppl.1 )   269 - 269   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 心血管・動脈硬化 耐糖能別にみた収縮期血圧と冠動脈疾患、脳血管疾患発症との関連

    山田 万祐子, 藤原 和哉, 大澤 妙子, 矢口 雄大, 北澤 勝, 松林 泰弘, 岩永 みどり, 清田 浩康, 山中 菜詩, 山田 貴穂, 曽根 博仁

    糖尿病合併症   34 ( Suppl.1 )   219 - 219   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 眼科処置を要する糖尿病重症眼疾患発生と飲酒についての検討

    山本 正彦, 藤原 和哉, 矢口 雄大, 大澤 妙子, 山田 万祐子, 松林 泰弘, 長谷部 日, 曽根 博仁

    糖尿病合併症   34 ( Suppl.1 )   269 - 269   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • Network Meta-Analysis of Drug Therapies for Lowering Uric Acid and Mortality Risk in Patients with Heart Failure. 国際誌

    Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Mayuko Yamada, Takaaki Sato, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Kenichi Watanabe, Hirohito Sone

    Cardiovascular drugs and therapy   35 ( 6 )   1217 - 1225   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: This network meta-analysis aimed to assess the current efficacy of decreasing the uric acid (UA) level with drugs to reduce mortality in patients with heart failure (HF). METHODS: Electronic literature searches using EMBASE and MEDLINE of studies published from 1 Jan 1950 to 26 Dec 2019 were conducted for randomized controlled trials or non-randomized cohort studies that included at least one group of patients who took UA-lowering drugs and with a study outcome of all-cause mortality. A random-effects network meta-analysis was performed within a frequentist framework. Hierarchy of treatments was expressed as the surface under the cumulative ranking curve (SUCRA) value, which is in proportion to mean rank (best is 100%). RESULTS: Nine studies, which included seven different types of groups, were eligible for analysis. The "untreated uricemia" group in which patients had hyperuricemia but without treatment had a significantly higher risk of mortality than the "no uricemia" group in which patients had no hyperuricemia (relative risk (RR)(95% confidence interval (CI), 1.43 (1.08-1.89)). The "start-allo" group wherein patients started to take allopurinol did not have a significantly lower risk of mortality than the "untreated uricemia" group (RR (95% CI), 0.68 (0.45-1.01)). However, in the "start-allo" group the SUCRA value was comparable to that in the "no uricemia" group (SUCRA: 65.4% for "start-allo"; 64.1% for "no uricemia"). CONCLUSIONS: Results suggested that allopurinol therapy was not associated with a significantly improved prognosis in terms of mortality but could potentially counteract the adverse effects associated with longstanding hyperuricemia in HF patients.

    DOI: 10.1007/s10557-020-07097-4

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  • A Prospective Cohort Study of Muscular and Performance Fitness and Incident Glaucoma: The Niigata Wellness Study. 国際誌

    Ryoko Kawakami, Yuko Gando, Kiminori Kato, Susumu S Sawada, Haruki Momma, Motohiko Miyachi, I-Min Lee, Steven N Blair, Minoru Tashiro, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Kazuya Fujihara, Hirohito Sone

    Journal of physical activity & health   17 ( 11 )   1 - 8   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: To examine the association between muscular and performance fitness (MPF) and the incidence of glaucoma. METHODS: A total of 27,051 glaucoma-free participants aged 20-87 years underwent physical fitness tests between April 2001 and March 2002. The MPF index was calculated using an age- and sex-specific summed z-score from grip strength, vertical jump, single-leg balance, forward bending, and whole-body reaction time. The participants were divided into quartiles according to the MPF index and each physical fitness test. Participants were followed up for the development of glaucoma, which was defined based on physician-diagnosed glaucoma at an annual health examination between April 2002 and March 2008. Hazard ratios for the incidence of glaucoma were estimated using Cox proportional hazards models. RESULTS: During follow-up, 303 participants developed glaucoma. Compared with the lowest MPF index group, hazard ratio (95% confidence interval) of developing glaucoma was 0.64 (0.46-0.89) for the highest MPF index group (P for trend = .001). Vertical jump and whole-body reaction time were associated with incident glaucoma (P for trend = .01 and <.001, respectively). There were no associations between the other physical fitness tests and the incidence of glaucoma. CONCLUSION: Higher MPF is associated with lower incidence of glaucoma.

    DOI: 10.1123/jpah.2019-0660

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  • Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis. 査読 国際誌

    Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Takaaki Sato, Midori Iwanaga, Takaho Yamada, Kiminori Kato, Kenichi Watanabe, Hitoshi Shimano, Tohru Izumi, Hirohito Sone

    ESC heart failure   7 ( 5 )   2146 - 2174   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Despite mounting evidence of the positive relationship between diabetes mellitus (DM) and heart failure (HF), the entire context of the magnitude of risk for HF in relation to DM remains insufficiently understood. The principal reason is because new-onset HF (HF occurring in participants without a history of HF) and recurrent HF (HF re-occurring in patients with a history of HF) are not discriminated. This meta-analysis aims to comprehensively and separately assess the risk of new-onset and recurrent HF depending on the presence or absence of DM. We systematically searched cohort studies that examined the relationship between DM and new-onset or recurrent HF using EMBASE and MEDLINE (from 1 Jan 1950 to 28 Jul 2019). The risk ratio (RR) for HF in individuals with DM compared with those without DM was pooled with a random-effects model. Seventy-four and 38 eligible studies presented data on RRs for new-onset and recurrent HF, respectively. For new-onset HF, the pooled RR [95% confidence interval (CI)] of 69 studies that examined HF as a whole [i.e. combining HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF)] was 2.14 (1.96-2.34). The large between-study heterogeneity (I2 = 99.7%, P < 0.001) was significantly explained by mean age [pooled RR (95% CI) 2.60 (2.38-2.84) for mean age < 60 years vs. pooled RR (95% CI) 1.95 (1.79-2.13) for mean age ≥ 60 years] (P < 0.001). Pooled RRs (95% CI) of seven and eight studies, respectively, that separately examined HFpEF and HFrEF risk were 2.22 (2.02-2.43) for HFpEF and 2.73 (2.71-2.75) for HFrEF. The risk magnitudes between HFpEF and HFrEF were not significantly different in studies that examined both HFpEF and HFrEF risks (P = 0.86). For recurrent HF, pooled RR (95% CI) of the 38 studies was 1.39 (1.33-1.45). The large between-study heterogeneity (I2 = 80.1%, P < 0.001) was significantly explained by the proportion of men [pooled RR (95% CI) 1.53 (1.40-1.68) for < 65% men vs. 1.32 (1.25-1.39) for ≥65% men (P = 0.01)] or the large pooled RR for studies of only participants with HFpEF [pooled RR (95% CI), 1.73 (1.32-2.26) (P = 0.002)]. Results indicate that DM is a significant risk factor for both new-onset and recurrent HF. It is suggested that the risk magnitude is large for new-onset HF especially in young populations and for recurrent HF especially in women or individuals with HFpEF. DM is associated with future HFpEF and HFrEF to the same extent.

    DOI: 10.1002/ehf2.12782

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  • Family Support for Medical Nutritional Therapy and Dietary Intake among Japanese with Type 2 Diabetes (JDDM 56). 国際誌

    Chika Horikawa, Mariko Hatta, Sakiko Yoshizawa Morikawa, Yasunaga Takeda, Mizuki Takeuchi, Kazuya Fujihara, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Shiro Tanaka, Hiroshi Maegawa, Hirohito Sone

    Nutrients   12 ( 9 )   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The aim of this study was to investigate the association between habitual dietary intake for patients with diabetes and the content of family support for medical nutritional therapy (MNT). Analyzed were 289 Japanese with type 2 diabetes (men, 58.5%; mean age, 62.0 years; mean HbA1c, 53.4 mmol/mol) who completed the Food Frequency Questionnaire and Diabetes Family Behavior Checklist (DFBC). Relationships of mean values for food group intake to DFBC responses regarding MNT were examined using multivariate analysis of covariance. Positive response to "Praise for following diet" was associated with lower sweets intake (none: 60.1 g/day; ≥once monthly: 50.9 g/day, p = 0.038) and higher seasoning intake (none: 21.6 g/day, ≥once monthly: 24.1 g/day, p = 0.046). Energy intake was higher with positive responses to "Eat at the same time that you do" (none: 1636 kcal/day, ≥once monthly: 1818 kcal/day, p = 0.038). "Nags about not following diet" was associated with higher fish (none: 68.7 g/day, ≥once monthly: 78.7 g/day, p = 0.042) and salt intake (none: 8.3 g/day, ≥once monthly: 9.0 g/day, p = 0.014). Eating foods not part of the diabetic diet (none: 218.4 g/day, ≥once monthly: 246.9 g/day, p = 0.014) resulted in a higher vegetable intake. In females, significant differences in relationships in the overall analysis were reversed. Our results clarified relationships between types of family support of patients with type 2 diabetes and their dietary intake and the importance of sex differences for more effective MNT.

    DOI: 10.3390/nu12092649

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  • Influence of an SGLT2 inhibitor, tofogliflozin, on the resting heart rate in relation to adipose tissue insulin resistance

    T. Nojima, Y. Matsubayashi, A. Yoshida, H. Suganami, T. Abe, M. Ishizawa, K. Fujihara, S. Tanaka, K. Kaku, H. Sone

    Diabetic Medicine   37 ( 8 )   1316 - 1325   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing Ltd  

    Aims: To examine the effects of a sodium–glucose co-transporter 2 (SGLT2) inhibitor, tofogliflozin, on resting heart rate by exploring baseline factors that independently influenced changes in the resting heart rate. Methods: Data on 419 participants in tofogliflozin phase 2/3 trials were analysed. Changes in resting heart rate from baseline to week 24 were analysed using an analysis of covariance (ANCOVA) model with groups (tofogliflozin/placebo) as a fixed effect and baseline values as covariates. The antilipolytic effect was evaluated as adipose tissue insulin resistance (Adipo-IR) and was calculated as the product of fasting insulin and free fatty acid. Multivariate analysis evaluated independent factors for changes in resting heart rate from baseline to week 24. Results: Of the participants, 58% were men, and mean age, HbA1c, BMI and resting heart rate were 57.6 years, 65 mmol/mol (8.1%), 25.5 kg/m2 and 66 bpm, respectively. At week 24, adjusted mean difference vs. placebo in the change from baseline was −2.3 bpm [95% confidence interval (CI) −4.6, −0.1] with tofogliflozin. Changes in resting heart rate were positively correlated with changes in Adipo-IR, whereas reductions in HbA1c, body weight and blood pressure were similar independent of changes in resting heart among quartiles of resting heart rate change. On multivariate analysis, higher baseline resting heart rates and Adipo-IR values were significantly associated with greater reductions in resting heart rate. Conclusions: Tofogliflozin corrected resting heart rate levels in accordance with baseline levels. Correction of high resting heart rates may be attributed to improved adipose tissue insulin resistance, leading to correction of hyperinsulinaemia.

    DOI: 10.1111/dme.14279

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  • 糖尿病の有無別にみた収縮期血圧が透析開始に及ぼす影響

    大澤 妙子, 藤原 和哉, 山田 万祐子, 山本 正彦, 北澤 勝, 松林 泰弘, 岩永 みどり, 清田 浩康, 山田 貴穂, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 172   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 耐糖能別にみた収縮期血圧が冠動脈/脳血管疾患に及ぼす影響の検討

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 岩永 みどり, 山中 菜詩, 清田 浩康, 山田 貴穂, 小川 渉, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 206   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病と定期的な運動習慣が要介護発症へ及ぼす影響の検討

    藤原 和哉, 山田 万祐子, 北澤 勝, 松林 泰弘, 矢口 雄大, 八尋 拓也, 筒井 歩, 山田 貴穂, 加藤 公則, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 148   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 日本人2型糖尿病患者の肥満に対するエネルギー摂取と身体活動の複合効果

    治田 麻理子, 藤原 和哉, 森川 咲子, 武田 安永, 堀川 千嘉, 加藤 光敏, 横山 宏樹, 栗原 義夫, 岩崎 皓一, 宮澤 一裕, 山崎 勝也, 田中 四郎, 前川 聡, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 171   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • SGLT2阻害薬52週投与及び投与中止2週後の推算血漿流量変化とBNPとの関連の検討

    松林 泰弘, 吉田 明弘, 野島 俊秋, 菅波 秀規, 石黒 創, 岩永 みどり, 山田 貴穂, 藤原 和哉, 加来 浩平, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 223   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病の有無別にみた日本人男性におけるBMI・腹囲と冠動脈疾患発症との関連

    上村 和樹, 藤原 和哉, 山田 万祐子, 北澤 勝, 矢口 雄大, 清田 浩康, 山中 菜詩, 松林 泰弘, 山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 229   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 服薬アドヒアランスと下肢切断のリスクとの関連に関する縦断的検討

    金子 正儀, 藤原 和哉, 山田 万祐子, 北澤 勝, 矢口 雄大, 清田 浩康, 山中 菜詩, 松林 泰弘, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 207   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 経口血糖降下薬(OHA)の服薬アドヒアランス(Ad)と血糖コントロールとの関係

    矢口 雄大, 藤原 和哉, 山田 万祐子, 北澤 勝, 金子 正儀, 清田 浩康, 山中 菜詩, 松林 泰弘, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 222   2020年8月

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  • 総合体力尺度から作成した体力年齢とメタボリックシンドローム(MetS)との関連

    佐藤 隆明, 藤原 和哉, 山田 万祐子, 矢口 雄大, 北澤 勝, 松林 泰弘, 岩永 みどり, 山田 貴穂, 加藤 公則, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 133   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • スマートフォンを含むスクリーンタイムと小児の生活習慣、食品群別摂取量および肥満との関連

    池田 和泉, 藤原 和哉, 根立 梨奈, 森川 咲子, 石黒 創, 山田 万祐子, 松林 泰弘, 山田 貴穂, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 275   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み(第2報)

    山田 貴穂, 武田 安永, 池田 和泉, 竹内 瑞希, 國米 純也, 中湊 大成, 滝澤 祥子, 村井 幸四郎, 竹内 亮, 今西 明, 安楽 匠, 岸 裕太郎, 小松 健, 佐藤 隆明, 矢口 雄大, 山田 万祐子, 川田 亮, 金子 正儀, 鈴木 浩史, 松林 泰弘, 藤原 和哉, 岩永 みどり, 鈴木 亜希子, 羽入 修, 曽根 博仁, 新潟県糖尿病協会

    糖尿病   63 ( Suppl.1 )   S - 349   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 2型糖尿病患者における野菜と果物の摂取と肥満との関連

    竹内 瑞希, 藤原 和哉, 治田 麻理子, 武田 安永, 堀川 千嘉, 斎藤 トシ子, 加藤 光敏, 加藤 則子, 横山 宏樹, 栗原 義夫, 岩崎 皓一, 宮澤 一裕, 山崎 勝也, 前川 聡, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 243   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 下垂体機能低下症を併発した本態性高Na血症の一例

    岸 裕太郎, 竹内 亮, 山本 正彦, 松林 泰弘, 山田 貴穂, 岩永 みどり, 石黒 創, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   96 ( 1 )   256 - 256   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 1型糖尿病に対して膵腎同時移植を施行し透析およびインスリンを離脱した1例

    岸 裕太郎, 竹内 亮, 山本 正彦, 松林 泰弘, 藤原 和哉, 岩永 みどり, 山田 高穂, 曽根 博仁, 三浦 宏平, 小林 隆, 若井 俊文

    糖尿病   63 ( 8 )   558 - 558   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • SGLT2阻害薬投与による肝インスリンクリアランス増加と血中トリグリセリド・βヒドロキシ酪酸レベルの変化との関連について

    松林 泰弘, 吉田 明弘, 菅波 秀規, 藤原 和哉, 加来 浩平, 曽根 博仁

    日本内分泌学会雑誌   96 ( 1 )   263 - 263   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 高齢になり副腎皮質機能低下症、甲状腺機能低下症が顕在化した下垂体茎離断症候群に甲状腺乳頭癌を合併した1例

    浅島 雄弥, 佐藤 隆明, 竹内 亮, 小松 健, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   96 ( 1 )   309 - 309   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 1型糖尿病に対して膵腎同時移植を施行し透析およびインスリンを離脱した1例

    岸 裕太郎, 竹内 亮, 山本 正彦, 松林 泰弘, 藤原 和哉, 岩永 みどり, 山田 高穂, 曽根 博仁, 三浦 宏平, 小林 隆, 若井 俊文

    糖尿病   63 ( 8 )   558 - 558   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 著明な嚥下障害を呈したKearns-Sayre症候群に合併した糖尿病の1例

    種村 聡, 山本 正彦, 石黒 創, 岩永 みどり, 松林 泰弘, 山田 貴穂, 藤原 和哉, 渡邊 賢一, 曽根 博仁

    糖尿病   63 ( 8 )   568 - 568   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice. 国際誌

    Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst Rejina Afrin, Remya Sreedhar, Meilei Harima, Masahiko Nakamura, Kenichi Watanabe, Satoru Kodama, Kazuya Fujihara, Hirohito Sone

    Neurochemistry international   137   104745 - 104745   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM AND OBJECTIVE: Insulin-induced moderate or severe hypoglycemia (MH or SH) impairs cognition and SH causes neuronal death. On the contrary, alternate day fasting (ADF) protects the brain during excitotoxic stress and improves cognitive function. Unlike the scenario in the periphery, insulin and its relationship towards brain glucose uptake and metabolism are considered to be less significant. Yet, the hypoglycemia associated brain metabolism is not clearly understood. The authors broadly investigated the brain metabolism in various hypoglycemic models such as insulin-induced MH, SH, SH with glucose reperfusion, 24 h fasting and ADF in the cortex or hippocampus of C57BL6/J mice. The authors analyzed the protein expression of insulin signaling kinases (plays a key role in neuronal survival and memory), Bcl-2 associated death promoter (p-BADser155) (dephosphorylation inhibits glucokinase activity and reduces glucose or increases ketone body metabolism in the brain), neuronal-specific glucose transporter 3 (GLUT 3) and nitrotyrosine (marker of nitric oxide which is involved in neuronal glucose uptake via GLUT 3) using western blotting analysis. RESULTS: Insulin-induced MH or SH differentially regulated the brain insulin signaling kinases. The expression of p-BADser155 decreased in all hypoglycemic models except the insulin-induced MH in hippocampus. The trended higher GLUT 3 and increased nitrotyrosine expression of insulin-induced SH were restored after glucose reperfusion. The trended higher or increased GLUT 3 and nitrotyrosine expression of ADF were positively correlated with serum beta-hydroxybutyrate levels. CONCLUSION: During hypoglycemia, it can be suggested that the brain might decrease glucose metabolism via glycolysis or prefer ketone body metabolism (except the insulin-induced MH in hippocampus) by modifying the p-BADser155 expression. In addition to the ketone body metabolism, the brain might adapt to uptake glucose in insulin-induced SH or ADF by modifying the GLUT 3 or nitrotyrosine expression.

    DOI: 10.1016/j.neuint.2020.104745

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  • 心不全患者に対する高尿酸血症治療薬の予後改善効果に関するネットワークメタ分析

    児玉 暁, 藤原 和哉, 渡辺 賢一, 加藤 公則, 曽根 博仁

    日本動脈硬化学会総会プログラム・抄録集   52回   234 - 234   2020年7月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes. 査読 国際誌

    Takuya Yamaoka, Atsushi Araki, Yoshiaki Tamura, Shiro Tanaka, Kazuya Fujihara, Chika Horikawa, Rei Aida, Chiemi Kamada, Yukio Yoshimura, Tatsumi Moriya, Yasuo Ohashi, Yasuo Akanuma, Hideki Ito, Hirohito Sone

    Nutrients   12 ( 6 )   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The aim of this study was to investigate the association between protein intake and mortality risk in patients with type 2 diabetes. We analyzed a pooled data of 2494 diabetic patients from two prospective longitudinal studies. Nutritional intake was assessed using a Food Frequency Questionnaire at baseline. Protein intake per body weight (kg) per day was categorized into quartile groups. Adjusted hazard ratios (HRs) and 95% confidence interval (CI) were calculated using Cox regression analysis. During the six-year follow-up, there were 152 incidents of all-cause mortality. The HR for mortality in the lowest quartile of protein intake per body weight compared with the highest quartile was 2.26 (95% CI: 1.34-3.82, p = 0.002) after adjustment for covariates. Subgroup analyses revealed significant associations between low protein intake and mortality in patients aged over 75 years or under 65 years. After further adjustment of the total energy intake, a significant association between protein intake and mortality remained in patients aged ≥ 75 years, whereas the association was attenuated in those aged < 65 years. Our results suggest that adequate protein intake is necessary in older diabetic patients over 75 years, whereas with diabetes, whereas whole optimal total energy intake is required in younger patients with type 2 diabetes.

    DOI: 10.3390/nu12061629

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  • Vitamin B6 intake and incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: analysis of data from the Japan Diabetes Complications Study (JDCS). 査読 国際誌

    Chika Horikawa, Rei Aida, Chiemi Kamada, Kazuya Fujihara, Shiro Tanaka, Sachiko Tanaka, Atsushi Araki, Yukio Yoshimura, Tatsumi Moriya, Yasuo Akanuma, Hirohito Sone

    European journal of nutrition   59 ( 4 )   1585 - 1594   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Although vitamin B6 has been suspected to prevent the progression of diabetic retinopathy, evidence of this in patients with type 2 diabetes based on longitudinal studies is sparse. This study investigated the relationship between vitamin B6 intake and the incidence of diabetic retinopathy in Japanese patients with type 2 diabetes. METHODS: The study was part of an examination of a nationwide cohort of patients with type 2 diabetes aged 40-70 years with HbA1c ≥ 48 mmol/mol. After excluding nonresponders to a dietary survey using the Food Frequency Questionnaire based on food groups, 978 patients were analyzed. Primary outcome was the 8-year risk of a diabetic retinopathy event, and Cox regression analyses estimated hazard ratios (HRs) for retinopathy according to vitamin B6 intake adjusted for age, gender, body mass index, HbA1c, smoking, energy intake, and other confounders. RESULTS: Mean vitamin B6 intake in quartiles ranged from 1.1 to 1.6 mg/day, and half of the participants had vitamin B6 intake below the recommended daily dietary allowance according to dietary reference intakes in Japanese adults (men 1.4 mg/day; women 1.2 mg/day). After adjusting for confounders, HRs for diabetic retinopathy in the 2nd, 3rd, and 4th quartile groups of vitamin B6 intake compared with the 1st quartile group were 1.17 (95% confidence interval 0.81-1.69, p = 0.403), 0.88 (0.58-1.34, p = 0.550), and 0.50 (0.30-0.85, p = 0.010), respectively. CONCLUSIONS: Findings suggested that high vitamin B6 intake was associated with a lower incidence of diabetic retinopathy in Japanese with type 2 diabetes.

    DOI: 10.1007/s00394-019-02014-4

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  • 糖尿病、非糖尿患者における血糖、血圧、脂質、喫煙の管理目標の達成状況と冠動脈疾患発症の検討

    藤原 和哉, 山田 万佑子, 曽根 博仁

    日本内科学会雑誌   109 ( Suppl. )   240 - 240   2020年2月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • 抗体陰性バセドウ病に合併した類もやもや病の1例

    滝澤 祥子, 今西 明, 安楽 匠, 川田 亮, 佐藤 隆明, 金子 正儀, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   134 ( 2 )   75 - 76   2020年2月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • Association of increased hepatic insulin clearance and change in serum triglycerides or β-hydroxybutyrate concentration via the sodium/glucose-cotransporter 2 inhibitor tofogliflozin. 査読 国際誌

    Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Taeko Osawa, Kazuo Furukawa, Hiroshi Suzuki, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

    Diabetes, obesity & metabolism   22 ( 6 )   947 - 956   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Obesity and hepatic fat accumulation diminish hepatic insulin clearance, which can cause hyperinsulinaemia. Sodium/glucose-cotransporter 2 inhibitors (SGLTis) improve insulin resistance and hyperinsulinaemia by weight loss via increased urinary glucose excretion in type 2 diabetes. However, there are few reports of the influence of SGLT2is on hepatic insulin clearance. We examined the impact of an SGLT2i on hepatic insulin clearance and explored the clinical influence associated with changes in hepatic insulin clearance via an SGLT2i and the mechanism of the effects of SGLT2i. MATERIALS AND METHODS: Data were analysed from 419 patients with type 2 diabetes controlled by diet and exercise. Patients received a placebo or the SGLT2i tofogliflozin (TOFO) (placebo: n = 56; TOFO: n = 363) orally once daily for ≥24 weeks. Hepatic insulin clearance was calculated from the ratio of areas under the curve (AUC) of C-peptide and insulin levels derived from oral meal tolerance test data (C-peptide AUC0-120 min /insulin AUC0-120 min : HICCIR ). The correlation of HICCIR via the SGLT2i with other clinical variables was analysed using multivariate analysis. RESULTS: HICCIR was significantly increased via TOFO at week 24. Furthermore, with TOFO insulin and triglyceride (TG) levels were significantly reduced (P <0.001) and β-hydroxybutyrate (BHB) was significantly elevated (P <0.001). Changes in HICCIR were significantly correlated with changes in TG and BHB via TOFO. CONCLUSIONS: Increased HICCIR was significantly associated with reduced TG via TOFO and contributed to the greater increase in BHB compared with placebo in addition to the correction of hyperinsulinaemia.

    DOI: 10.1111/dom.13980

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  • Combination of diabetes mellitus and lack of habitual physical activity is a risk factor for functional disability in Japanese. 査読 国際誌

    Kazuya Fujihara, Yasuhiro Matsubayashi, Mayuko Harada Yamada, Masaru Kitazawa, Masahiko Yamamoto, Masanori Kaneko, Satoru Kodama, Takuya Yahiro, Ayumu Tsutsui, Kiminori Kato, Hirohito Sone

    BMJ open diabetes research & care   8 ( 1 )   2020年1月

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    記述言語:英語  

    OBJECTIVE: Declining healthy life expectancy due to functional disability is relevant and urgent because of its association with decreased quality of life and also for its enormous socioeconomic impact. The aim of this study is to examine the impact of diabetes, hypertension, dyslipidemia and physical activity habits on functional disability among community-dwelling Japanese adults. RESEARCH DESIGN AND METHODS: This is a population-based retrospective cohort study including 9673 people aged 39-98 years in Japan (4420, men). Functional disability was defined as a condition meeting Japan's new long-term care insurance certification requirements for the need of assistance in the activities of daily living whether by caregivers or assistive devices. Cox proportional-hazards regression model identified variables related to functional disability. RESULTS: Median follow-up was 3.7 years. During the study period, 165 disabilities occurred in the overall study population. Multivariate analysis showed that diabetes (HR 1.74 (95% CI 1.12 to 2.68)) and no physical activity habit (HR 1.83 (1.27 to 2.65)) presented increased risks for disability. HR for disability increased with the number of risk factors (HR of individuals with four conditions, 3.96 (1.59 to 9.99) vs individuals with none of those conditions as a reference). HR for disability among patients with diabetes with and without a physical activity habit was 1.68 (0.70 to 4.04) and 3.19 (1.79 to 5.70), respectively, compared with individuals without diabetes with a physical activity habit. CONCLUSIONS: The combination of diabetes and lack of habitual physical activity is predictive of functional disability in Japanese. Habitual physical activity attenuates the risk of functional disability in patients with diabetes.

    DOI: 10.1136/bmjdrc-2019-000901

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  • 副甲状腺癌の全身骨転移と鑑別が困難でありBrown腫瘍が疑われた一例 査読

    山本 正彦, 種村 聡, 石黒 創, 松林 泰弘, 藤原 和哉, 岩永 みどり, 山田 貴穂, 曽根 博仁

    日本内分泌学会雑誌   95 ( 3 )   998 - 998   2020年1月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Weight and cardiometabolic risk among adolescents in Agano city, Japan: NICE EVIDENCE Study-Agano 1. 国際誌

    Sakiko Yoshizawa Morikawa, Kazuya Fujihara, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Masahiro Ishizawa, Masahiko Yamamoto, Tomonobu Shiraishi, Hajime Ishiguro, Takaho Yamada, Yohei Ogawa, Hirohito Sone

    Asia Pacific journal of clinical nutrition   29 ( 4 )   856 - 866   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND OBJECTIVES: Pediatric obesity is associated with clustered cardiometabolic risk and the future incidence of cardiovascular disease. However, few studies have determined the effect of pediatric obesity in Asia, where obesity is less common than in Western countries. We aimed to clarify whether weight status including underweight and slightly overweight is associated with metabolic risk factors in Japanese adolescents. METHODS AND STUDY DESIGN: We performed a cross-sectional analysis of 2241 adolescents aged 13-14 years. Participants were classified as underweight, normal weight, slightly overweight, overweight, or obese according to the International Obesity Task Force. The clustered cardiometabolic risk (Z-CMR) was estimated by summing standardized sex-specific Z scores of mean arterial pressure (MAP), non-high-density lipoprotein cholesterol (non-HDLC), and HbA1c. RESULTS: Linear regression analysis showed that MAP, non-HDL-C, and Z-CMR were higher in the slightly overweight, overweight, and obese groups than in the normal weight group after adjusting for confounders. Compared with the normal weight group, the slightly overweight, overweight, and obese groups had higher prevalence of high BP [odds ratios (ORs): 1.38 (95% CI, 1.03, 1.85); 2.63 (1.77, 3.91); and 2.39 (1.57, 3.64), respectively]. Compared with the normal weight group, underweight boys, but not girls, had a lower prevalence of high Z-CMR [OR=0.20 (0.05, 0.84)]. CONCLUSIONS: Adolescents classified as slightly overweight had higher levels of BP, serum lipids, and clustered cardiometabolic risk than those classified as normal weight. This observation showed significant associations between weight status and cardiometabolic risk factors during adolescence even in East Asians.

    DOI: 10.6133/apjcn.202012_29(4).0022

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  • Physical Fitness and Dyslipidemia Among Japanese: A Cohort Study From the Niigata Wellness Study

    Haruki Momma, Kiminori Kato, Susumu S. Sawada, Yuko Gando, Ryoko Kawakami, Motohiko Miyachi, Ryoichi Nagatomi, Minoru Tashiro, Yasuhiro Matsubayashi, Satoru Kodama, Midori Iwanaga, Kazuya Fujihara, Hirohito Sone

    Journal of Epidemiology   2020年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Epidemiological Association  

    DOI: 10.2188/jea.je20200034

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  • Association between Screen Time Including Smartphone Use and Obesity and Its Associated Lifestyles in School Children in Japan

    Ikeda, Izumi, Fujihara, Kazuya, Nedachi, Rina, Morikawa, Sakiko Y., Ishiguro, Hajime, Yamada, Mayuko H., Matsubayashi, Yasuhiro, Yamada, Takaho, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-1988-P

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  • Impact of Body Mass Index (BMI) and Waist Circumference (WC) on Coronary Artery Disease (CAD) in Japanese with and without Diabetes Mellitus (DM)

    Komatsu, Takeshi, Fujihara, Kazuya, Yamada, Mayuko H., Sato, Takaaki, Kitazawa, Masaru, Yamamoto, Masahiko, Seida, Hiroyasu, Yamanaka, Nauta, Matsubayashi, Yasuhiro, Yamada, Takaho, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-449-P

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  • Medication Adherence (MA) Is an Independent Predictor for Glycemic Control Even after Adjustment for Lifestyle Confounders in Japanese Patients with Type 2 Diabetes

    Yaguchi, Yuta, Fujihara, Kazuya, Yamada, Mayuko H., Sato, Takaaki, Kitazawa, Masaru, Yamamoto, Masahiko, Seida, Hiroyasu, Yamanaka, Nauta, Matsubayashi, Yasuhiro, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-663-P

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  • Predictive Ability of Incident Type 2 Diabetes Mellitus (T2DM) Using Machine Learning Algorithms: A Meta-analysis

    Kodama, Satoru, Sato, Takaaki, Yamamoto, Masahiko, Ishiguro, Hajime, Iwanaga, Midori, Fujihara, Kazuya, Yamada, Takaho, Kato, Kiminori, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-841-P

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  • Randomized Controlled Trial of Ipragliflozin or Sitagliptin Combined with Metformin in Type 2 Diabetes: NISM Study

    Kitazawa, Masaru, Katagiri, Takashi, Suzuki, Hiromi, Matsunaga, Satoshi, Yamada, Mayuko H., Ikarashi, Tomoo, Yamamoto, Masahiko, Furukawa, Kazuo, Iwanaga, Midori, Hatta, Mariko, Fujihara, Kazuya, Yamada, Takaho, Tanaka, Shiro, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-1126-P

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  • Physical Fitness (PF), Weight Status, and Metabolic Risk in Japanese Adolescents

    Morikawa, Sakiko Y., Fujihara, Kazuya, Nedachi, Rina, Ikeda, Izumi, Takeda, Yasunaga, Takeuchi, Mizuki, Hatta, Mariko, Ishiguro, Hajime, Yamada, Takaho, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-1267-P

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  • Low Level of and Decrease in Serum Amylase (AMY) Increases the Risk of Type 2 Diabetes Mellitus (T2DM)

    Ikeda, Izumi, Fujihara, Kazuya, Risa, Igarashi, Yamada, Mayuko H., Nedachi, Rina, Hatta, Mariko, Kodama, Satoru, Mori, Yasumichi, Matsubayashi, Yasuhiro, Arase, Yasuji, Sone, Hirohito, Yamamoto-Honda, Ritsuko

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-1903-P

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  • Difference between Comprehensive Physical Fitness Age and Calendar Age Is a Potent Predictor of Incident Metabolic Syndrome (MetS)

    Sato, Takaaki, Fujihara, Kazuya, Yamada, Mayuko H., Yaguchi, Yuta, Kitazawa, Masaru, Matsubayashi, Yasuhiro, Iwanaga, Midori, Yamada, Takaho, Kato, Kiminori, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-1485-P

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  • Blood Pressure as Predictor of Coronary Artery Disease (CAD)/Cerebrovascular Disease (CVD) According to Glucose Tolerance Status (GTS): Implications for Updated Guidelines

    Yamada, Mayuko H., Fujihara, Kazuya, Yaguchi, Yuta, Osawa, Taeko, Kitazawa, Masaru, Matsubayashi, Yasuhiro, Iwanaga, Midori, Yamada, Takaho, Yamanaka, Nauta, Seida, Hiroyasu, Ogawa, Wataru, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-6-OR

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  • Ability for Detecting or Predicting Hypoglycemia with the Aid of Machine Learning Techniques: A Meta-analysis

    Kodama, Satoru, Yamada, Mayuko H., Yaguchi, Yuta, Kitazawa, Masaru, Kaneko, Masanori, Matsubayashi, Yasuhiro, Fujihara, Kazuya, Iwanaga, Midori, Kato, Kiminori, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-389-P

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  • Association between Plasma Metabolites in the Urea Cycle and Diabetic Kidney Disease (DKD) in a Japanese Population

    Yamamoto, Masahiko, Harada, Sei, Okamura, Tomonori, Fujihara, Kazuya, Yaguchi, Yuta, Komatsu, Takeshi, Sato, Takaaki, Kitazawa, Masaru, Yamada, Mayuko H., Kaneko, Masanori, Osawa, Taeko, Matsubayashi, Yasuhiro, Yamada, Takaho, Kodama, Satoru, Sone, Hirohito, Takebayashi, Toru

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-518-P

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  • Association of Plasma Volume with Body Weight and BNP after Long-Term Administration and Subsequent Withdrawal of the SGLT2 Inhibitor Tofogliflozin

    Matsubayashi, Yasuhiro, Yoshida, Akihiro, Nojima, Toshiaki, Suganami, Hideki, Fujihara, Kazuya, Kaku, Kohei, Sone, Hirohito

    Diabetes   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2337/DB20-1125-P

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  • Risk of coronary artery disease according to glucose abnormality status and prior coronary artery disease in Japanese men. 査読 国際誌

    Masaru Kitazawa, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Mayuko Harada Yamada, Masanori Kaneko, Yasuhiro Matsubayashi, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Hirohito Sone

    Metabolism: clinical and experimental   101   153991 - 153991   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Although glucose abnormality status (GAS), prior coronary artery disease (CAD), and other traditional risk factors affect the incidence of subsequent CAD, their impact in the same cohort has been scantly studied. RESEARCH DESIGN AND METHODS: We analyzed data from a nationwide claims database in Japan that was accumulated during 2008-2016 involving 138,162 men aged 18-72 years. Participants were classified as having normoglycemia, borderline glycemia, or diabetes mellitus (DM) with prior CAD (CAD+) or without prior CAD (CAD-). Cox regression model identified variables related to the incidence of CAD. RESULTS: Among CAD-, management of traditional risks differed from those with and without subsequent CAD events. On the other hand, such differences were weaker in borderline glycemia and DM CAD+, and the influence of traditional risk factors on subsequent CAD was not observed. Cox regression model showed that borderline glycemia and DM confer approximately 1.2- and 2.8-fold excess risks of CAD, respectively, compared with CAD- with normoglycemia. CAD+ confers approximately a 5- to 8-fold increased risk. The impacts of DM and prior CAD additively reached a hazard ratio (HR) of 15.74 (95% confidence interval [CI]: 11.82-21.00). However, the HR in those with borderline glycemia and CAD+ was 7.20 (95% CI: 5.01-10.34), which was not different from those with normoglycemia and CAD+. CONCLUSION: Control status of traditional risk factors and impact on subsequent CAD differ among categories of glycemic status with and without prior CAD. Individualizing treatment strategies is needed in consideration of risk factors, such as GAS and CAD+.

    DOI: 10.1016/j.metabol.2019.153991

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  • Relationship Between Number of Multiple Risk Factors and Coronary Artery Disease Risk With and Without Diabetes Mellitus. 査読 国際誌

    Mayuko Yamada-Harada, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Wataru Ogawa, Hirohito Sone

    The Journal of clinical endocrinology and metabolism   104 ( 11 )   5084 - 5090   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To determine the degree of control of multiple risk factors under real-world conditions for coronary artery disease (CAD) according to the presence or absence of diabetes mellitus (DM) and to determine whether reaching multifactorial targets for blood pressure (BP), low-density lipoprotein-cholesterol (LDL-C), HbA1c, and current smoking is associated with lower risks for CAD. METHODS: We investigated the effects on subsequent CAD of the number of controlled risk factors among BP, LDL-C, HbA1c, and current smoking in a prospective cohort study using a nationwide claims database of 220,894 individuals in Japan. Cox regression examined risks over a 4.8-year follow-up. RESULTS: The largest percentage of participants had two risk factors at target in patients with DM (39.6%) and subjects without DM (36.4%). Compared with those who had two targets achieved, the risks of CAD among those who had any one and no target achieved were two and four times greater, respectively, regardless of the presence of DM. The effect of composite control was sufficient to bring CAD risk in patients with DM below that for subjects without DM with any two targets achieved, whereas the risk of CAD in the DM group with all four risk factors uncontrolled was 9.4 times more than in the non-DM group who had achieved two targets. CONCLUSIONS: These findings show that composite control of modifiable risk factors has a large effect in patients with and without DM. The effect was sufficient to bring CAD risk in patients with DM below that in the non-DM group who had two targets achieved.

    DOI: 10.1210/jc.2019-00168

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  • 下垂体性と異所性の鑑別に苦慮したACTH依存性クッシング症候群の1例

    佐藤 隆明, 金子 正儀, 福武 嶺一, 小松 健, 今西 明, 安楽 匠, 竹内 真理, 竹内 亮, 岸 裕太郎, 矢口 雄大, 山本 正彦, 川田 亮, 石黒 創, 松林 康弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   133 ( 9-10 )   352 - 352   2019年10月

  • 局在診断に苦慮している周期性ACTH依存性クッシング症候群の1例

    金子 正儀, 佐藤 隆明, 福武 嶺一, 滝澤 祥子, 今西 明, 安楽 匠, 小松 健, 松林 泰弘, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁, 岡田 正康, 小原 伸雅, 米岡 有一郎

    日本内分泌学会雑誌   95 ( 2 )   765 - 765   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Attenuation of Weight Loss Through Improved Antilipolytic Effect in Adipose Tissue Via the SGLT2 Inhibitor Tofogliflozin. 査読 国際誌

    Akihiro Yoshida, Yasuhiro Matsubayashi, Toshiaki Nojima, Hideki Suganami, Takahiro Abe, Masahiro Ishizawa, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

    The Journal of clinical endocrinology and metabolism   104 ( 9 )   3647 - 3660   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    CONTEXT: Although calorie loss from increased urinary glucose excretion continues after long-term treatment with sodium-glucose cotransporter 2 inhibitors (SGLT2is), the mechanisms of the attenuated weight loss due to SGLT2is are not well known. OBJECTIVE: To examine the mechanism of the attenuated weight loss during long-term treatment with an SGLT2i, tofogliflozin, focusing on the antilipolytic effect of insulin on adipose tissue. DESIGN AND PARTICIPANTS: An integrated analysis was performed using data from two phase 3 studies of 52 weeks of tofogliflozin administration. The antilipolytic effect was evaluated using adipose tissue insulin resistance (Adipo-IR) calculated from the product of the levels of fasting insulin (f-IRI) and fasting free fatty acids (f-FFAs). RESULTS: Data from 774 patients with type 2 diabetes (mean age, 58.5 years; glycosylated hemoglobin, 8.1%; body mass index, 25.6 kg/m2; estimated glomerular filtration rate, 83.9 mL/min/1.73m2; 66% men) were analyzed. Weight loss plateaued between weeks 24 and 52 after decreasing significantly. f-IRI levels decreased significantly from baseline to week 24, and the decrease was maintained until Week 52. f-FFA levels significantly increased, peaked at week 24, then declined from weeks 24 to 52. Adipo-IR levels declined progressively throughout the 52 weeks (-3.6 mmol/L·pmol/L and -6.2 mmol/L·pmol/L at weeks 24 and 52, respectively; P < 0.001 baseline vs weeks 24 and 52 and week 24 vs week 52). Higher baseline Adipo-IR levels were independently associated with greater weight loss at week 52. CONCLUSION: The improved antilipolytic effect in adipose tissue may attenuate progressive lipolysis, leading to attenuating future weight loss induced by an SGLT2i in patients with type 2 diabetes.

    DOI: 10.1210/jc.2018-02254

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  • 大血管障害 糖尿病、非糖尿患者における血糖・血圧・脂質・喫煙の管理目標の達成状況と冠動脈疾患発症の関連 査読

    山田 万祐子, 藤原 和哉, 大澤 妙子, 山本 正彦, 石澤 正博, 金子 正儀, 松林 泰弘, 清田 浩康, 山田 貴穂, 曽根 博仁

    糖尿病合併症   33 ( Suppl.1 )   241 - 241   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 大血管障害 耐糖能状態及び心血管疾患既往の有無で層別化した、心血管疾患発症リスクの検討 査読

    北澤 勝, 藤原 和哉, 山田 万祐子, 大澤 妙子, 山本 正彦, 矢口 雄大, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    糖尿病合併症   33 ( Suppl.1 )   242 - 242   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 眼科処置を要する重症糖尿病性眼疾患発生リスクと血液学的因子の関係についての検討 査読

    山本 正彦, 藤原 和哉, 大澤 妙子, 山田 万祐子, 石澤 正博, 石黒 創, 鈴木 浩史, 松林 泰弘, 児玉 暁, 長谷部 日, 曽根 博仁

    糖尿病合併症   33 ( Suppl.1 )   263 - 263   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 運動の疫学を再考する 小児生活習慣病対策における体力の意義 新潟小児生活習慣病研究から得られた知見を中心として

    森川 咲子, 藤原 和哉, 曽根 博仁

    日本臨床運動療法学会学術集会プログラム・抄録集   38回   27 - 27   2019年8月

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    記述言語:日本語   出版者・発行元:(NPO)日本臨床運動療法学会  

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  • Effect of family-oriented diabetes programs on glycemic control: A meta-analysis. 査読 国際誌

    Satoru Kodama, Sakiko Morikawa, Chika Horikawa, Dai Ishii, Kazuya Fujihara, Masahiko Yamamoto, Taeko Osawa, Masaru Kitazawa, Takaho Yamada, Kiminori Kato, Shiro Tanaka, Hirohito Sone

    Family practice   36 ( 4 )   387 - 394   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Efficacy of programs for patients with diabetes mellitus (DM) that have promoted family members to help with patients' self-care activities has been largely inconsistent. This meta-analysis aims to assess the effect of family-oriented diabetes programs for glycemic control (GC). METHODS: Electronic literature searches were conducted for clinical trials with a parallel design wherein there were two groups according to whether family members were included (intervention group) or not included (control group) and changes in glycohemoglobin A1C (A1C) were assessed as a study outcome. Each effect size (i.e. difference in A1C change between the intervention and control group) was pooled with a random-effects model. RESULTS: There were 31 eligible trials consisting of 1466 and 1415 patients in the intervention and control groups, respectively. Pooled A1C change [95% confidence interval (CI)] was -0.45% (-0.64% to -0.26%). Limiting analyses to 21 trials targeted at patients with type 1 DM or 9 trials targeted at patients with type 2 DM, the pooled A1C changes (95% CI) were -0.35% (-0.55% to -0.14%) and -0.71% (-1.09% to -0.33%), respectively. CONCLUSION: This meta-analysis suggests that focusing on the family as well as the individual patient in self-management diabetes programs to improve the performance of self-care activities of patients with DM is effective in terms of proper GC.

    DOI: 10.1093/fampra/cmy112

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  • Blake's pouch cystに伴う水頭症の治療により若年性認知症の改善を認めた糖尿病の1例 査読

    種村 聡, 山本 正彦, 石黒 創, 岩永 みどり, 松林 泰弘, 山田 貴穂, 藤原 和哉, 渡邊 賢一, 曽根 博仁

    糖尿病   62 ( 7 )   441 - 441   2019年7月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Overt Proteinuria, Moderately Reduced eGFR and Their Combination Are Predictive of Severe Diabetic Retinopathy or Diabetic Macular Edema in Diabetes. 査読 国際誌

    Masahiko Yamamoto, Kazuya Fujihara, Masahiro Ishizawa, Taeko Osawa, Masanori Kaneko, Hajime Ishiguro, Yasuhiro Matsubayashi, Hiroyasu Seida, Nauta Yamanaka, Shiro Tanaka, Satoru Kodama, Hiruma Hasebe, Hirohito Sone

    Investigative ophthalmology & visual science   60 ( 7 )   2685 - 2689   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Purpose: Since the combined effects of proteinuria and a moderately decreased eGFR on incident severe eye complications in patients with diabetes are still largely unknown, these associations were determined in a large historical cohort of Japanese patients with diabetes mellitus. Methods: We evaluated the effects of overt proteinuria (OP) (dipstick 1+ and over) and/or moderately reduced estimated glomerular filtration rate (eGFR) (MG) (baseline eGFR 30.0-54.9 mL/min/1.73 m2) on the incidence of treatment-required diabetic eye diseases (TRDED). We divided 7709 patients into four groups according to the presence or absence of OP and MG: no OP without MG (NP[MG-]), OP without MG (OP[MG-]), no OP with MG (NP[MG+]), and OP with MG (OP[MG+]). Multivariate Cox analyses were performed to calculate hazard ratios (HRs) with 95% confidence intervals for combinations of the presence and/or absence of OP and MG on the risk of developing TRDED. Results: During the median follow-up period of 5.6 years, 168 patients developed TRDED. HRs for OP and MG for incident TRDED were 1.91 (95% confidence interval, 1.27-2.87) and 1.90 (1.11-3.23), respectively. HRs for incident TRDED were 1.73 (1.11-2.69) and 5.57 (2.40-12.94) for OP(MG-) and OP(MG+), respectively, in comparison with NP(MG-). Conclusions: In Japanese patients with diabetes, OP and MG were separately as well as additionally associated with higher risks of TRDED. Results indicate the necessity of the simultaneous assessment of proteinuria and eGFR for appropriate evaluation of risks of severe eye complications in patients with diabetes.

    DOI: 10.1167/iovs.19-26749

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  • Combined Effects of Energy Intake and Physical Activity on Obesity in Japanese Patients with Type 2 Diabetes (JDDM 50): A Cross-Sectional Study. 査読 国際誌

    Mariko Hatta, Kazuya Fujihara, Sakiko Yoshizawa Morikawa, Yasutake Takeda, Dai Ishii, Chika Horikawa, Mitsutoshi Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Kazuhiro Miyazawa, Katsuya Yamazaki, Shiro Tanaka, Hiroshi Maegawa, Hirohito Sone

    Diabetes therapy : research, treatment and education of diabetes and related disorders   10 ( 3 )   1133 - 1138   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: The combined effects of energy intake (EI) and physical activity (PA) on obesity have been poorly investigated. We have investigated the combined effects of EI and PA quantitatively in Japanese men and women with type 2 diabetes. METHODS: Data on 1395 patients with type 2 diabetes who attended 25 diabetes clinics located throughout Japan, obtained by questionnaire, were analyzed. A logistic regression model was used to calculate the odds ratio for obesity. RESULTS: Multi-adjusted odds ratios for the top versus the bottom tertile of EI and the bottom versus the top tertile of PA were 1.39 (95% confidence interval [CI] 1.02-1.89) and 1.64 (95% CI 1.22-2.22), respectively. The combination of EI (kcal/day) ≥ 1967 and PA (metabolic equivalents [METs] h/week) ≤ 9.9 for men and of EI ≥ 1815 and PA ≤ 8.3 for women were significantly associated with obesity. CONCLUSIONS: The existence of "allowable maximum EI" and "required minimum PA" that is significantly associated with "not being obese" is implied, suggesting the need for lifestyle education for Japanese patients with type 2 diabetes.

    DOI: 10.1007/s13300-019-0610-x

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  • Pulse Pressure is a Stronger Predictor Than Systolic Blood Pressure for Severe Eye Diseases in Diabetes Mellitus. 査読 国際誌

    Masahiko Yamamoto, Kazuya Fujihara, Masahiro Ishizawa, Taeko Osawa, Masanori Kaneko, Hajime Ishiguro, Yasuhiro Matsubayashi, Hiroyasu Seida, Nauta Yamanaka, Shiro Tanaka, Satoru Kodama, Hiruma Hasebe, Hirohito Sone

    Journal of the American Heart Association   8 ( 8 )   e010627   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background Evidence of the role of systolic blood pressure ( SBP ) in development of severe diabetic retinopathy is not strong, although the adverse effect of low diastolic blood pressure has been a partial explanation. We assessed the predictive ability of incident severe diabetic retinopathy between pulse pressure ( PP ) which considers both SBP and diastolic blood pressure, compared with SBP . Methods and Results Eligible patients (12 242, 83% men) aged 19 to 72 years from a nationwide claims database were analyzed for a median observational 4.8-year period. Severe diabetic retinopathy was defined as vision-threatening treatment-required diabetic eye diseases. Multivariate Cox regression analysis revealed that hazard ratios (95% CI ) of treatment-required diabetic eye diseases for 1 increment of standard deviation and the top tertile compared with the bottom tertile were 1.39 (1.21-1.60) and 1.72 (1.17-2.51), respectively, for PP and 1.22 (1.05-1.41) and 1.43 (0.97-2.11), respectively, for SBP adjusted for age, sex, body mass index, hemoglobin A1c, fasting plasma glucose, lipids, and smoking status. In a model with SBP and PP simultaneously as covariates, the hazard ratios of only PP (hazard ratios [95% CI ], 1.57 [1.26-1.96]) but not SBP (0.85 [0.68-1.07]) were statistically significant. Delong test revealed a significant difference in the area under the receiver operating characteristic curve between PP and SBP (area under the receiver operating characteristic curve [95% CI ], 0.58 [0.54-0.63] versus 0.54 [0.50-0.59]; P=0.03). The strongest predictor remained as hemoglobin A1c (area under the receiver operating characteristic curve [95% CI ], 0.80 [0.77-0.84]). Conclusions After excluding the significant impact of glycemic control, PP in comparison with SBP is a better predictor of severe diabetic retinopathy, suggesting a role of diastolic blood pressure and arterial stiffness in pathology.

    DOI: 10.1161/JAHA.118.010627

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  • 耐糖能状態と心血管疾患既往の有無別に見たその後の心血管疾患発症リスク 査読

    北澤 勝, 藤原 和哉, 原田 万祐子, 大澤 妙子, 山本 正彦, 矢口 雄大, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 190   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病の有無別にみた高血圧が透析導入に及ぼす影響の検討 査読

    大澤 妙子, 藤原 和哉, 山本 正彦, 原田 万祐子, 北澤 勝, 金子 正儀, 石黒 創, 石澤 正博, 松林 泰弘, 清田 浩康, 山中 菜詩, 山田 貴穂, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 219   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 医療ビッグデータを用いた糖尿病患者の下肢切断に関するリスク因子の検討 査読

    金子 正儀, 藤原 和哉, 原田 万祐子, 山本 正彦, 松林 泰弘, 北澤 勝, 石井 大, 清田 浩康, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 195   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病(DM)・冠動脈疾患(CAD)・脳血管疾患(CVD)の既往及び組み合わせがその後のリスクへ及ぼす影響の検討 査読

    藤原 和哉, 松林 泰弘, 原田 万祐子, 大澤 妙子, 金子 正儀, 山本 正彦, 山田 高穂, 清田 浩康, 加藤 公則, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 254   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study. 査読

    Momma H, Sawada SS, Kato K, Gando Y, Kawakami R, Miyachi M, Huang C, Nagatomi R, Tashiro M, Ishizawa M, Kodama S, Iwanaga M, Fujihara K, Sone H

    Journal of epidemiology   29 ( 4 )   139 - 146   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20170280

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  • 2型糖尿病患者における食事エネルギー密度と食事パターンとの関連 査読

    武田 安永, 藤原 和哉, 治田 麻理子, 森川 咲子, 堀川 千嘉, 石井 大, 根立 梨奈, 加藤 光敏, 横山 宏樹, 栗原 義夫, 宮澤 一裕, 岩崎 晧一, 川井 紘一, 朝長 修, 屋宜 宣治, 前川 聡, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 116   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病の有無別にみた血糖・血圧・脂質・喫煙の各管理目標達成状況が冠動脈疾患発症に及ぼす影響 査読

    原田 万祐子, 藤原 和哉, 大澤 妙子, 石澤 正博, 山本 正彦, 金子 正儀, 松林 泰弘, 清田 浩康, 山田 貴穂, 小川 渉, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 285   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 血清アミラーゼ値およびその経時変化が2型糖尿病発症に及ぼす影響の定量的検討

    石井 大, 藤原 和哉, 根立 梨奈, 原田 万佑子, 松林 泰弘, 斎藤 和美, 児玉 暁, 森 保道, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 219   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • (わが国における)経口血糖降下薬の服薬アドヒアランスの現況とその関連因子

    矢口 雄大, 藤原 和哉, 原田 万祐子, 金子 正儀, 松林 泰弘, 北澤 勝, 清田 浩康, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 263   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 脂肪細胞インスリン抵抗性からみたSGLT2阻害薬投与によるケトン体上昇予測因子の検討

    松林 泰弘, 吉田 明弘, 野島 俊秋, 菅波 秀規, 石黒 創, 岩永 みどり, 山田 貴穂, 藤原 和哉, 加来 浩平, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 126   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes. 査読 国際誌

    Taeko Osawa, Kazuya Fujihara, Mayuko Harada, Masahiko Yamamoto, Masahiro Ishizawa, Hiroshi Suzuki, Hajime Ishiguro, Yasuhiro Matsubayashi, Hiroyasu Seida, Nauta Yamanaka, Shiro Tanaka, Hitoshi Shimano, Satoru Kodama, Hirohito Sone

    Diabetes/metabolism research and reviews   35 ( 3 )   e3120   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: To determine incidence and predictors of starting dialysis in patients with diabetes emphasizing blood pressure variables. METHODS: A nationwide database with claim data on 18 935 people (15 789 men and 3146 women) with diabetes mellitus aged 19 to 72 years in Japan was used to elucidate predictors for starting dialysis. Initiation of dialysis was determined from claims using ICD-10 codes and medical procedures. Using multivariate Cox modelling, interactions between glycaemic and blood pressure values were determined. RESULTS: During a median follow-up of 5.3 years, incidence of dialysis was 0.81 per 1000 person-years. Multivariate analysis of a model involving systolic and diastolic blood pressure (SBP and DBP) simultaneously as covariates showed that hazard ratios (HRs) for starting dialysis for each 1-SD elevation in SBP and DBP were 2.05 (95% confidence interval 1.58-2.64) and 0.66 (0.50-0.88), respectively, implying that pulse pressure (PP) was a promising predictor. For confirmation, a model involving SBP and PP simultaneously as covariates demonstrated that HRs for each 1-SD elevation in SBP and PP were 1.09 (0.81-1.48) and 1.54 (1.14-2.08), respectively, with PP the more potent predictor. Compared with HbA1c <8% and PP <60 mmHg, the HR for those with HbA1c ≥8% and PP ≥60 mmHg was 6.32 (3.42-11.7). CONCLUSIONS: In our historical cohort analysis, SBP and PP were independent predictors for starting dialysis. PP was the more potent, suggesting the contribution of increased arterial stiffness to the incidence of dialysis. Future studies are needed to conclude the independent influence of PP and HbA1c on dialysis considering other risk factors.

    DOI: 10.1002/dmrr.3120

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  • Meat intake and incidence of cardiovascular disease in Japanese patients with type 2 diabetes: analysis of the Japan Diabetes Complications Study (JDCS). 査読 国際誌

    Chika Horikawa, Chiemi Kamada, Shiro Tanaka, Sachiko Tanaka, Atsushi Araki, Hideki Ito, Satoshi Matsunaga, Kazuya Fujihara, Yukio Yoshimura, Yasuo Ohashi, Yasuo Akanuma, Hirohito Sone

    European journal of nutrition   58 ( 1 )   281 - 290   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Excessive meat intake has been researched as a major cause of cardiovascular disease (CVD) among healthy adults, but data on this topic in Asian patients with diabetes are sparse. The quantity and variety of available meats vary widely between Asian and Western countries. As part of a nationwide cohort study we investigated the relationship between meat intake and incidence of CVD in Japanese patients with type 2 diabetes aged 40-70 years with HbA1c ≥ 6.5%. METHODS: Analyzed were 1353 responders to a baseline dietary survey assessed by the Food Frequency Questionnaire based on food groups. Primary outcome was the 8-year risk of a CVD event, including coronary heart disease (CHD) and stroke. Cox regression analyses estimated hazard ratios (HRs) for dietary intake adjusted for age, gender, body mass index, HbA1c, smoking, energy intake, and other confounders. RESULTS: Mean meat intake in quartiles ranged from 9.9 to 97.7 g/day. After adjusting for confounders, HRs of CHD in the 2nd, 3rd, and 4th quartiles for meat intake compared with the 1st quartile were 2.84 (95% confidence interval 1.29-6.24, p = 0.01), 3.02 (1.36-6.70, p < 0.01), and 2.99 (1.35-6.65, p = 0.01), respectively. In two groups according to meat intake, patients consuming ≥ 20 g/day of meat had a 2.94-fold higher risk of CHD than those consuming < 20 g/day (p < 0.01). There was no significant association of stroke with meat intake. CONCLUSIONS: An elevated incidence of CHD in Japanese patients with type 2 diabetes was associated with high meat intake.

    DOI: 10.1007/s00394-017-1592-y

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  • Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study. 査読

    Momma H, Sawada SS, Kato K, Gando Y, Kawakami R, Miyachi M, Huang C, Nagatomi R, Tashiro M, Ishizawa M, Kodama S, Iwanaga M, Fujihara K, Sone H

    J Epidemiol   29 ( 4 )   139 - 146   2019年

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  • 当科で経験した下垂体茎断裂症候群の1例 査読

    佐藤 隆明, 金子 正儀, 福武 嶺一, 安楽 匠, 種村 聡, 今西 明, 矢口 雄大, 山本 正彦, 鈴木 達郎, 石黒 創, 松林 泰弘, 山田 貴穂, 岩永 みどり, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   132 ( 11-12 )   399 - 399   2018年12月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 当科で経験した下垂体茎断裂症候群の1例 査読

    佐藤 隆明, 金子 正儀, 福武 嶺一, 安楽 匠, 種村 聡, 今西 明, 矢口 雄大, 山本 正彦, 鈴木 達郎, 石黒 創, 松林 泰弘, 山田 貴穂, 岩永 みどり, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   132 ( 11-12 )   399 - 399   2018年12月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis. 査読 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Dai Ishii, Mariko Hatta, Yasunaga Takeda, Masaru Kitazawa, Yasuhiro Matsubayashi, Hitoshi Shimano, Kiminori Kato, Shiro Tanaka, Hirohito Sone

    Clinical nutrition ESPEN   27   53 - 58   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND & AIMS: High intake of fruit and vegetables is recommended for cardiovascular health. However, there have been persistent beliefs that fruits having high concentrations of fructose elevate the level of triglycerides (TG) in blood unlike vegetables. This meta-analysis aims to clarify the relationship between fruit intake and TG or hypertriglyceridemia. METHODS: Electronic literature searches were conducted for observational studies that investigated the relationship between fruit intake and hypertriglyceridemia or intervention studies that investigated the effect of increasing fruit intake on TG. Each effect size was pooled with an inverse-variance method. RESULTS: Five cross-sectional studies and only 2 intervention studies were eligible. The pooled odds ratio (OR) (95% confidence interval (CI)) of the 5 cross-sectional studies for the highest vs. the lowest fruit intake category was 0.79 (0.72-0.87). In these studies, the pooled OR for the highest vs. the lowest vegetable intake category was not significant (OR = 0.92; 95% CI, (0.82-1.03)). A linear dose-response association was observed between increases in fruit intake and ORs for hypertriglyceridemia; the OR (95% CI) for an incrementally increased intake of fruit by 1 serving/day was 0.91 (0.84-0.98). CONCLUSION: This meta-analysis suggests that high intake of fruit but not vegetables is inversely associated with hypertriglyceridemia. More trials are needed to clarify whether increasing fruit intake would reduce the level of TG and/or incident hypertriglyceridemia.

    DOI: 10.1016/j.clnesp.2018.07.001

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  • Network meta‐analysis of the relative efficacy of bariatric surgeries for diabetes remission 査読

    Kodama S, Fujihara K, Horikawa C, Harada M, Ishiguro H, Kaneko M, Furukawa K, Matsubayashi Y, Matsunaga S, Shimano H, Tanaka S, Kato K, Sone H

    Obesity reviews   19 ( 12 )   1621 - 1629   2018年9月

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  • ステロイド糖尿病を合併し歯性感染から上顎の骨髄炎を発症した2型糖尿病の1例 査読

    棚橋 怜生, 山本 正彦, 松林 泰弘, 松永 佐澄志, 山田 貴穂, 岩永 みどり, 藤原 和哉, 羽入 修, 曽根 博仁

    糖尿病   61 ( 9 )   644 - 644   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病重症視力障害発症とHbA1cの関連性についての検討 査読

    山本 正彦, 藤原 和哉, 五十嵐 理沙, 石澤 正博, 松林 泰弘, 松永 佐澄志, 伊藤 知恵, 錦野 理絵, 山中 菜詩, 児玉 暁, 曽根 博仁

    日本糖尿病眼学会誌   22   134 - 134   2018年9月

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    記述言語:日本語   出版者・発行元:日本糖尿病眼学会  

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  • 糖尿病重症視力障害発症とHbA1cの関連性についての検討 査読

    山本 正彦, 藤原 和哉, 五十嵐 理沙, 石澤 正博, 松林 泰弘, 松永 佐澄志, 伊藤 知恵, 錦野 理絵, 山中 菜詩, 児玉 暁, 曽根 博仁

    日本糖尿病眼学会誌   22   134 - 134   2018年9月

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    記述言語:日本語   出版者・発行元:日本糖尿病眼学会  

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  • 下肢皮膚潰瘍から骨髄炎に至った2型糖尿病の1例

    張 かおり, 金子 正儀, 佐藤 陽子, 松林 泰弘, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 羽入 修, 曽根 博仁

    糖尿病   61 ( 9 )   646 - 646   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes 査読

    Shoko Furukawa, Hiroaki Suzuki, Kazuya Fujihara, Kazuto Kobayashi, Hitoshi Iwasaki, Yoko Sugano, Shigeru Yatoh, Motohiro Sekiya, Naoya Yahagi, Hitoshi Shimano

    Diabetes Research and Clinical Practice   141   237 - 243   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background and aims: Oxidized low-density lipoprotein (oxLDL) causes the development of atherosclerosis and kidney injury. Although circulating oxLDL levels were reportedly increased in type 2 diabetic patients with macroalbuminuria, it remains unclear whether albuminuria or the reduced glomerular filtration rate (GFR) is independently associated with the circulating oxLDL level. This study aimed to elucidate the association between the stage of diabetic nephropathy and serum malondialdehyde-modified LDL (MDA-LDL) and the ratio of MDA-LDL to LDL-cholesterol (MDA-LDL/LDL). Methods and results: This retroactive cross-sectional study used data from 402 patients with type 2 diabetes. Patients undergoing hemodialysis were excluded. Serum MDA-LDL levels were significantly increased with increases in severity of albuminuria (103 ± 44 U/L, 109 ± 54 U/L, and 135 ± 72 U/L for normoalbuminuria, microalbuminuria, and macroalbuminuria, respectively
    P for trend = 0.020) but not according to the estimated GFR (eGFR). An increased MDA-LDL/LDL ratio was significantly associated with both increased albuminuria (35 ± 13, 37 ± 14, and 40 ± 15 for normoalbuminuria, microalbuminuria, and macroalbuminuria, respectively
    P for trend = 0.003) and reduced eGFR (34 ± 13, 36 ± 13, 38 ± 12, and 51 ± 28 for grade 1, 2, 3 and 4, respectively
    P for trend = 0.002). Multiple linear regression analysis showed that neither the albumin excretion rate nor eGFR but ln-transformed triglycerides and LDL-C levels were independent determinants of both serum MDA-LDL levels and MDA-LDL/LDL ratios. Conclusion: Serum MDA-LDL levels and MDA-LDL/LDL ratios were increased in those with dyslipidemia associated with diabetic kidney disease.

    DOI: 10.1016/j.diabres.2018.05.019

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  • Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2

    Morikawa, Sakiko Yoshizawa, Fujihara, Kazuya, Hatta, Mariko, Osawa, Taeko, Ishizawa, Masahiro, Yamamoto, Masahiko, Furukawa, Kazuo, Ishiguro, Hajime, Matsunaga, Satoshi, Ogawa, Yohei, Shimano, Hitoshi, Sone, Hirohito

    Pediatric diabetes   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

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  • Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2. 査読 国際誌

    Sakiko Yoshizawa Morikawa, Kazuya Fujihara, Mariko Hatta, Taeko Osawa, Masahiro Ishizawa, Masahiko Yamamoto, Kazuo Furukawa, Hajime Ishiguro, Satoshi Matsunaga, Yohei Ogawa, Hitoshi Shimano, Hirohito Sone

    Pediatric diabetes   19 ( 4 )   593 - 602   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To examine the independent and combined associations of cardiorespiratory fitness (CRF) and muscular fitness (MF) with cardiometabolic risk factors in Japanese adolescents. METHODS: A cross-sectional study including 993 Japanese adolescents (aged 13-14 years) was undertaken. Height, body mass, blood pressure, lipid profile (non-fasting), and HbA1c were measured. The physical fitness (PF) test included measurements of CRF (20 m multistage shuttle run test), upper limb strength (hand grip strength), lower limb strength (standing long jump), and muscular endurance (sit-ups). The clustered cardiometabolic risk (CCMR) was estimated by summing standardized Z-scores of body mass index (BMI), mean arterial pressure (MAP), non-high-density lipoprotein cholesterol (non-HDL-C), and HbA1c. RESULTS: Linear regression analysis showed that all PF factors except for muscular endurance were inversely correlated with CCMR (P < .001). Among metabolic risk components, HbA1c was unrelated to PF, while non-HDL-C was inversely associated with CRF (B = -2.40; P < .001), upper limb strength (B = -1.77; P < .05), and lower limb strength (B = -1.53; P < .05) after adjustment for lifestyle factors. Logistic regression showed that the probability of having high CCMR (≥1SD) was synergistically higher in those with the lowest tertiles of both CRF and upper limb strength (P for interaction = .001); however, a substantially lower likelihood of having high CCMR was observed among individuals with the lowest tertile of upper limb strength but moderate CRF. CONCLUSIONS: Lower CRF and MF were significantly and synergistically associated with an unhealthier metabolic risk profile.

    DOI: 10.1111/pedi.12623

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  • 糖尿病患者における脈圧が透析導入に及ぼす影響の検討 査読

    大澤 妙子, 藤原 和哉, 山本 正彦, 原田 万由子, 石澤 正博, 清田 浩康, 山中 菜詩, 松林 泰弘, 松永 佐澄志, 山田 貴穂, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 160   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 診断に難渋した再発性重症低血糖の原因特定に薬物血中濃度測定が有用であった一例 査読

    三ツ間 友里恵, 山本 正彦, 橋本 浩平, 金子 正儀, 松林 泰弘, 松永 佐澄志, 山田 貴穂, 岩永 みどり, 藤原 和哉, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 181   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病治療薬別にみたHbA1cと冠動脈疾患(CAD)発症リスクとの関連 査読

    原田 万祐子, 藤原 和哉, 大澤 妙子, 石澤 正博, 山本 正彦, 金子 正儀, 松林 泰弘, 松永 佐澄志, 山中 菜詩, 清田 浩康, 山田 貴穂, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 258   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 肥満境界型糖尿病患者に対する血糖自己測定と栄養指導媒体を用いた栄養教育の併用効果について 査読

    長谷川 美代, 堀川 千嘉, 田代 稔, 鈴木 沙織, 藤原 和哉, 北澤 勝, 加藤 公則, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 267   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 2型糖尿病患者における食事エネルギー密度と肥満との関連 JDDMにおける検討 査読

    武田 安永, 藤原 和哉, 治田 麻理子, 森川 咲子, 堀川 千嘉, 石井 大, 加藤 光敏, 横山 宏樹, 栗原 義夫, 宮澤 一裕, 岩崎 晧一, 川井 紘一, 朝長 修, 屋宜 宣治, 前川 聡, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 265   2018年4月

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  • 眼科処置を要する重症糖尿病性眼疾患の発生リスクに対する腎症の影響についての検討 査読

    山本 正彦, 藤原 和哉, 大澤 妙子, 原田 万祐子, 石黒 創, 石澤 正博, 岩永 みどり, 松永 佐澄志, 松林 泰弘, 清田 浩康, 山中 菜詩, 山田 貴穂, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 161   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み 査読

    山田 貴穂, 石井 大, 武田 安永, 橋本 浩平, 三ツ間 友里恵, 張 かおり, 原田 万祐子, 白石 友信, 吉岡 大志, 山本 正彦, 大澤 妙子, 石黒 創, 金子 正儀, 鈴木 浩史, 松林 泰弘, 松永 佐澄志, 藤原 和哉, 岩永 みどり, 鈴木 亜希子, 羽入 修, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 377   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 耐糖能及び肥満の有無に関わらず代謝異常は冠動脈疾患発症リスクを増大させる 査読

    藤原 和哉, 松林 泰弘, 山本 正彦, 松永 佐澄志, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 260   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 当院における糖尿病合併妊娠及び妊娠糖尿病患者への分割食の栄養指導の実態と指導方法の検討

    治田 麻理子, 深沢 尚子, 桜井 健一, 津野 菜津美, 佐藤 かえで, 西山 陽子, 藤原 和哉, 曽根 博仁, 鈴木 克典

    糖尿病   61 ( Suppl.1 )   S - 214   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • DPP-4阻害薬アナグリプチン(ANA)の12週間投与時におけるインスリンクリアランスに及ぼす影響

    阿部 孝洋, 松林 泰弘, 村岸 沙也加, 吉田 明弘, 菅波 秀規, 古澤 研一, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 加来 浩平, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 246   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病患者の受診中断に関連する因子の1年間追跡調査 糖尿病データマネジメント研究会(JDDM)より

    谷内田 潤子, 藤原 和哉, 武田 安永, 治田 麻里子, 石井 大, 和井田 結佳子, 大石 まり子, 川井 紘一, 横山 宏樹, 前川 聡, 曽根 博仁, 糖尿病データマネジメント研究会

    糖尿病   61 ( Suppl.1 )   S - 139   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • SGLT2阻害薬が安静時心拍数(Resting Heart Rate:RHR)に及ぼす影響とその関連因子の検討

    松林 泰弘, 阿部 孝洋, 吉田 明弘, 野島 俊秋, 菅波 秀規, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 加来 浩平, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 158   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 年齢層別に見た血清アミラーゼ値と2型糖尿病発症との関連

    石井 大, 藤原 和哉, 治田 麻理子, 原田 万佑子, 松林 泰弘, 斎藤 和美, 児玉 暁, 森 保道, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 161   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Role of fatty liver in the association between obesity and reduced hepatic insulin clearance. 査読

    Matsubayashi Y, Yoshida A, Suganami H, Ishiguro H, Yamamoto M, Fujihara K, Kodama S, Tanaka S, Kaku K, Sone H

    Diabetes Metab   44 ( 2 )   135 - 142   2018年3月

  • Predictors of the response of HbA1c and body weight after SGLT2 inhibition. 査読

    Abe T, Matsubayashi Y, Yoshida A, Suganami H, Nojima T, Osawa T, Ishizawa M, Yamamoto M, Fujihara K, Tanaka S, Kaku K, Sone H

    Diabetes Metab   44 ( 2 )   172 - 174   2018年3月

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  • Cardiovascular Disease in Japanese Patients with Type 2 Diabetes Mellitus. 査読

    Fujihara K, Sone H

    Annals of vascular diseases   11 ( 1 )   2 - 14   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3400/avd.ra.17-00109

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  • Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis. 査読

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    Journal of epidemiology   28 ( 1 )   3 - 18   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Many epidemiological studies have assessed the genetic risk of having undiagnosed or of developing type 2 diabetes mellitus (T2DM) using several single nucleotide polymorphisms (SNPs) based on findings of genome-wide association studies (GWAS). However, the quantitative association of cumulative risk alleles (RAs) of such SNPs with T2DM risk has been unclear. The aim of this meta-analysis is to review the strength of the association between cumulative RAs and T2DM risk. Systematic literature searches were conducted for cross-sectional or longitudinal studies that examined odds ratios (ORs) for T2DM in relation to genetic profiles. Logarithm of the estimated OR (log OR) of T2DM for 1 increment in RAs carried (1-ΔRA) in each study was pooled using a random-effects model. There were 46 eligible studies that included 74,880 cases among 249,365 participants. In 32 studies with a cross-sectional design, the pooled OR for T2DM morbidity for 1-ΔRA was 1.16 (95% confidence interval [CI], 1.13-1.19). In 15 studies that had a longitudinal design, the OR for incident T2DM was 1.10 (95% CI, 1.08-1.13). There was large heterogeneity in the magnitude of log OR (P < 0.001 for both cross-sectional studies and longitudinal studies). The top 10 commonly used genes significantly explained the variance in the log OR (P = 0.04 for cross-sectional studies; P = 0.006 for longitudinal studies). The current meta-analysis indicated that carrying 1-ΔRA in T2DM-associated SNPs was associated with a modest risk of prevalent or incident T2DM, although the heterogeneity in the used genes among studies requires us to interpret the results with caution.

    DOI: 10.2188/jea.JE20160151

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  • Two-year assessment of the therapeutic efficacy of dipeptidyl peptidase-4 inhibitors or sulfonylureas in Japanese drug-naive patients with type 2 diabetes (JDDM 44)

    Koichi Kawai, Shinobu Motohashi, Kazuya Fujihara, Katsuya Yamazaki, Yoshio Kurihara, Koichi Hirao, Hidekatsu Sugimoto, Hiroshi Takamura, Azuma Kanatsuka, Hiroshi Maegawa

    Journal of the Japan Diabetes Society   61 ( 4 )   161 - 170   2018年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Diabetes Society  

    We retrospectively analyzed the CoDiC data from 33 institutes in the Japan Diabetes Clinical Data Management Study Group in order to clarify the therapeutic efficacy of DPP-4 inhibitors (DPP-4is) and sulfonylureas (SUs) in Japanese patients with type 2 diabetes who have not previously received pharmacologic treatment. At the end of July in 2015, 498 and 349 patients were treated for more than two years with DPP-4is and SUs, respectively. In comparison to SUs, the DPP-4is group showed a more prominent HbA1c reduction (even in patients with a higher initial HbA1c [<9.0 %]), a higher proportion of patients who continued monotherapy with the initial agent, and a higher proportion of patients with an HbA1c value of <7.0 %. Additional hypoglycemic therapy was administered to 42 % of the patients treated with DPP-4is and 54 % of the patients treated with SUs
    this mainly involved biguanide treatment (DPP-4i vs SU
    53 % vs 56 %). Among the DPP-4itreated patients, weight gain was only observed in the patients with an initial HbA1c value of >10 %, whereas it was observed irrespective of the initial HbA1c value in the SU-treated patients. These results were confirmed by a propensity score matching analysis. In conclusion, these results suggest that DPP-4is show superior therapeutic efficacy to SUs as an insulin secretion promoting agent in the treatment of drug-naive type 2 diabetes patients.

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  • Impact of body mass index and metabolic phenotypes on coronary artery disease according to glucose tolerance status. 査読 国際誌

    K Fujihara, Y Matsubayashi, M Yamamoto, T Osawa, M Ishizawa, M Kaneko, S Matsunaga, K Kato, H Seida, N Yamanaka, S Kodama, H Sone

    Diabetes & metabolism   43 ( 6 )   543 - 546   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: This study aimed to examine the impact of obesity, as defined by body mass index (BMI), and a metabolically unhealthy phenotype on the development of coronary artery disease (CAD) according to glucose tolerance status. METHODS: This population-based retrospective cohort study included 123,746 Japanese men aged 18-72years (normal glucose tolerance: 72,047; prediabetes: 39,633; diabetes: 12,066). Obesity was defined as a BMI≥25kg/m2. Metabolically unhealthy individuals were defined as those with one or more of the following conditions: hypertension, hypertriglyceridaemia and/or low HDL cholesterol. A Cox proportional hazards regression model identified variables related to CAD incidence. RESULTS: The prevalences of obese subjects with normal glucose tolerance, prediabetes and diabetes were 21%, 34% and 53%, whereas those for metabolically unhealthy people were 43%, 60% and 79%, respectively. Multivariate analysis showed that a metabolically unhealthy phenotype increases hazard ratios (HRs) for CAD compared with a metabolically healthy phenotype, regardless of glucose tolerance status (normal glucose tolerance: 1.98, 95% CI: 1.32-2.95; prediabetes: 2.91, 95% CI: 1.85-4.55; diabetes: 1.90, 95% CI: 1.18-3.06). HRs for CAD among metabolically unhealthy non-obese diabetes patients and obese diabetes patients with a metabolically unhealthy status were 6.14 (95% CI: 3.94-9.56) and 7.86 (95% CI: 5.21-11.9), respectively, compared with non-obese subjects with normal glucose tolerance and without a metabolically unhealthy status. CONCLUSION: A metabolically unhealthy state can associate with CAD independently of obesity across all glucose tolerance stages. Clinicians may need to consider those with at least one or more conditions indicating a metabolically unhealthy state as being at high risk for CAD regardless of glucose tolerance status.

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  • Association between all-cause mortality arid severity of depressive symptoms in patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS) 査読

    Satoshi Matsunaga, Shiro Tanaka, Kazuya Fujihara, Chika Horikawa, Satoshi Iimuro, Masafumi Kitaoka, Asako Sato, Jiro Nakamura, Masakazu Haneda, Hitoshi Shimano, Yasuo Akanuma, Yasuo Ohashi, Hirohito Sone

    JOURNAL OF PSYCHOSOMATIC RESEARCH   99   34 - 39   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Objective: The aims of this study are to confirm whether the excess mortality caused by depressive symptoms is independent of severe hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and to evaluate the association between all-cause mortality and degrees of severity of depressive symptoms in Japanese patients with T2DM.
    Methods: A total of 1160 Japanese patients with T2DM were eligible for this analysis. Participants were followed prospectively for 3 years and their depressive states were evaluated at baseline by the Center for Epidemiologic Studies Depression Scale (CES-D). Cox proportional hazards model was used to evaluate the relative risk of all cause mortality and was adjusted by possible confounding factors, including severe hypoglycemia, all of which are known as risk factors for both depression and mortality.
    Results: After adjustment for severe hypoglycemia, each 5-point increase in the CES-D score was significantly associated with excess all-cause mortality (hazard ratio 1.69 [95% CI 1.26-2.17]). The spline curve of HRs for mortality according to total CES-D scores showed that mortality risk was slightly increased at lower scores but was sharply elevated at higher scores.
    Conclusion: A high score on the CES-D at baseline was significantly associated with all-cause mortality in patients with T2DM after adjusting for confounders including severe hypoglycemia. However, only a small effect on mortality risk was found at relatively lower levels of depressive symptoms in this population. Further research is needed to confirm this relationship between the severity of depressive symptoms and mortality in patients with T2DM.

    DOI: 10.1016/j.jpsychores.2017.05.020

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  • Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis 査読

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    JOURNAL OF DIABETES INVESTIGATION   8 ( 4 )   501 - 509   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Aims/Introduction: The present meta-analysis aimed to clarify the association of unstable bodyweight with the risk of type 2 diabetes mellitus, an association that has been controversial among longitudinal studies.
    Materials and Methods: An electronic literature search using EMBASE and MEDLINE was followed up to 31 August 2016. The relative risks (RRs) of type 2 diabetes mellitus in individuals with unstable bodyweight were pooled using the inverse variance method.
    Results: Eight studies were eligible for the meta-analysis. The median duration of measurements of weight change and follow-up years for ascertaining type 2 diabetes mellitus were 13.5 and 9.4 years, respectively. The pooled RR for the least vs most stable category was 1.33 (95% confidence interval 1.12-1.57). Between-study heterogeneity was statistically significant (P = 0.048). Whether type 2 diabetes mellitus was ascertained by blood testing explained 66.0% of the variance in the logarithm of RR (P = 0.02). In three studies in which blood testing was carried out, type 2 diabetes mellitus risk was not significant (RR 1.06, 95% confidence interval 0.91-1.25). Furthermore, publication bias that inflated type 2 diabetes mellitus risk was statistically detected by Egger's test (P = 0.09).
    Conclusions: Unstable bodyweight might be modestly associated with the elevated risk of type 2 diabetes mellitus; although serious biases, such as diagnostic suspicion bias and publication bias, made it difficult to assess this association.

    DOI: 10.1111/jdi.12623

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  • Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis. 査読

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    Journal of diabetes investigation   8 ( 4 )   501 - 509   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS/INTRODUCTION: The present meta-analysis aimed to clarify the association of unstable bodyweight with the risk of type 2 diabetes mellitus, an association that has been controversial among longitudinal studies. MATERIALS AND METHODS: An electronic literature search using EMBASE and MEDLINE was followed up to 31 August 2016. The relative risks (RRs) of type 2 diabetes mellitus in individuals with unstable bodyweight were pooled using the inverse variance method. RESULTS: Eight studies were eligible for the meta-analysis. The median duration of measurements of weight change and follow-up years for ascertaining type 2 diabetes mellitus were 13.5 and 9.4 years, respectively. The pooled RR for the least vs most stable category was 1.33 (95% confidence interval 1.12-1.57). Between-study heterogeneity was statistically significant (P = 0.048). Whether type 2 diabetes mellitus was ascertained by blood testing explained 66.0% of the variance in the logarithm of RR (P = 0.02). In three studies in which blood testing was carried out, type 2 diabetes mellitus risk was not significant (RR 1.06, 95% confidence interval 0.91-1.25). Furthermore, publication bias that inflated type 2 diabetes mellitus risk was statistically detected by Egger's test (P = 0.09). CONCLUSIONS: Unstable bodyweight might be modestly associated with the elevated risk of type 2 diabetes mellitus; although serious biases, such as diagnostic suspicion bias and publication bias, made it difficult to assess this association.

    DOI: 10.1111/jdi.12623

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  • Impact of Obesity and Metabolic Phenotypes on Coronary Artery Disease (CAD) According to Glucose Tolerance Status 査読

    Kazuya Fujihara, Satoru Kodama, Masahiko Yamamoto, Satoshi Matsunaga, Yasuhiro Matsubayashi, Masahiro Ishizawa, Mieko Koishi, Chie Ito, Nauta Yamanaka, Kiminori Kato, Hirohito Sone

    DIABETES   66   A406 - A406   2017年6月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.1016/j.diabet.2017.08.002

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  • Associations between Hypertension and End-Stage Renal Disease (ESRD) in People With and Without Diabetes 査読

    Atsushi Furuya, Kazuya Fujihara, Masahiro Ishizawa, Masahiko Yamamoto, Yasuhiro Matsubayashi, Satoshi Matsunaga, Chie Ito, Mieko Koishi, Nauta Yamanaka, Kiminori Kato, Satoru Kodama, Hirohito Sone

    DIABETES   66   A138 - A138   2017年6月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

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  • Impact of glucose tolerance status on the development of coronary artery disease among working-age men 査読

    K. Fujihara, R. Igarashi, M. Yamamoto, M. Ishizawa, Y. Matsubayasi, S. Matsunaga, K. Kato, C. Ito, M. Koishi, N. Yamanaka, S. Kodama, H. Sone

    DIABETES & METABOLISM   43 ( 3 )   261 - 264   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MASSON EDITEUR  

    Aims. To examine the impact of glucose tolerance status on the development of coronary artery disease (CAD) in working-age men in Japan.
    Methods. This population-based retrospective cohort study included 111,621 men aged 31-60 years [63,558 with normal glucose tolerance (NGT); 37,126 with prediabetes; 10,937 with diabetes]. The Cox proportional-hazards regression model was used to identify variables related to the incidence of CAD.
    Results. Multivariate analysis showed that, compared with NGT, diabetes increased the risk of CAD by 17.3 times (95% CI: 6.36-47.0) at ages 31-40 years, by 2.74 times (95% CI: 1.85-4.05) at ages 41-50 years and by 2.47 times (95% CI: 1.69-3.59) at ages 51-60 years. The HRs for CAD in men with diabetes aged 31-40 equaled that of men with NGT aged 51-60 [18.2 (7.15-46.4) and 19.4 (8.28-45.4), respectively].
    Conclusion. The impact of diabetes on CAD was markedly greater in men aged 31-40 years compared with those aged 41-60 years. (C) 2016 Elsevier Masson SAS. All rights reserved.

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  • Reversible splenial lesion syndrome with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome caused by olanzapine 査読

    Kenta Kaino, Ryo Kumagai, Shoko Furukawa, Momoko Isono, Aiko Muramatsu, Masanao Fujii, Yumiko Muta, Tomoyuki Asada, Kazuya Fujihara, Hiroaki Yagyu

    Journal of Diabetes Investigation   8 ( 3 )   392 - 394   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing  

    A 27-year-old woman with panic disorder taking 20 mg olanzapine daily for 4 months was admitted to Mito Kyodo General Hospital, Mito, Ibaraki, Japan, because of disturbed consciousness with fever, hyperglycemia, hyperosmolarity and elevated creatine phosphokinase. She was diagnosed with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome. Brain magnetic resonance imaging showed transiently restricted diffusion in the splenium of the corpus callosum, with a high signal intensity on diffusion-weighted imaging. The neurological abnormalities disappeared along with improvement of metabolic derangements, and the follow-up magnetic resonance imaging carried out on the 26th day of admission showed complete resolution of the lesions in the splenium of the corpus callosum. These clinical and radiological features are highly suggestive of clinically mild encephalitis/encephalopathy with a reversible splenial lesion. The first case of mild encephalitis/encephalopathy with a reversible splenial lesion caused by olanzapine-induced hyperosmolar hyperglycemic state and neuroleptic malignant syndrome is reported.

    DOI: 10.1111/jdi.12597

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  • Reversible splenial lesion syndrome with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome caused by olanzapine 査読

    Kenta Kaino, Ryo Kumagai, Shoko Furukawa, Momoko Isono, Aiko Muramatsu, Masanao Fujii, Yumiko Muta, Tomoyuki Asada, Kazuya Fujihara, Hiroaki Yagyu

    JOURNAL OF DIABETES INVESTIGATION   8 ( 3 )   392 - 394   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    A 27-year-old woman with panic disorder taking 20 mg olanzapine daily for 4 months was admitted to Mito Kyodo General Hospital, Mito, Ibaraki, Japan, because of disturbed consciousness with fever, hyperglycemia, hyperosmolarity and elevated creatine phosphokinase. She was diagnosed with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome. Brain magnetic resonance imaging showed transiently restricted diffusion in the splenium of the corpus callosum, with a high signal intensity on diffusion-weighted imaging. The neurological abnormalities disappeared along with improvement of metabolic derangements, and the follow-up magnetic resonance imaging carried out on the 26th day of admission showed complete resolution of the lesions in the splenium of the corpus callosum. These clinical and radiological features are highly suggestive of clinically mild encephalitis/encephalopathy with a reversible splenial lesion. The first case of mild encephalitis/encephalopathy with a reversible splenial lesion caused by olanzap-ine- induced hyperosmolar hyperglycemic state and neuroleptic malignant syndrome is reported.

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  • Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42) 査読

    Kazuya Fujihara, Risa Igarashi, Satoshi Matsunaga, Yasuhiro Matsubayashi, Takaho Yamada, Hiroki Yokoyama, Shiro Tanaka, Hitoshi Shimano, Hiroshi Maegawa, Katsuya Yamazaki, Koichi Kawai, Hirohito Sone

    MEDICINE   96 ( 7 )   e6122   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Little is known about the relationships between patient factors and the antihyperglycemic agents that have been prescribed as initial therapy by diabetes specialists for patients with type 2 diabetes. Moreover, there has been little clarification of the subsequent usage patterns and related factors that influenced the continuation or discontinuation of the drug or the addition of another drug. To provide information on these issues, we evaluated the clinical characteristics of Japanese patients with type 2 diabetes for whom different types of oral hypoglycemic agents (i.e., either sulfonylureas, biguanides, or DPP-4 inhibitors (DPP-4Is)) were chosen as initial monotherapy by diabetes specialists and evaluated subsequent usage patterns.
    Prescription data on 3 different antidiabetic agents from December 2009 to March 2015 from diabetes specialists' patient registries were used to identify variables at baseline related to initial prescriptions; also, the addition of another hypoglycemic drug or discontinuation of the initial therapy was evaluated 1 year after the initial prescription. Analyzed were data on 2666 patients who received initial monotherapy with either a sulfonylurea (305 patients), biguanide (951 patients), or DPP-4I (1410 patients). Patients administered sulfonylureas were older, had a lower body mass index (BMI), longer duration of diabetes, and worse glycemic control than recipients of biguanides. Use of biguanides was related to younger age, short duration of diabetes, and obesity but was negatively associated with poor glycemic control. Older age but neither obesity nor poor glycemic control was associated with DPP-4Is. In all 3 groups a high HbA1c value was related to adding another hypoglycemic agent to the initial therapy. Moreover, adding another drug to a DPP-4I was related to a younger age and higher BMI.
    Patients' age, duration of diabetes, obesity, and glycemic control at baseline influenced the choice of hypoglycemic agents. Selection of a biguanide differs greatly from that of a sulfonylurea or DPP-4I with regard to age and obesity.

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  • Prevalence of non-communicable diseases and number of comorbidities according to differences in household income levels in Japan: Analysis from National Health and Nutrition Survey. 査読

    Horikawa C, Murayama N, Ota A, Tsuruta M, Matsunaga S, Fujihara K, Hanyu O, Sone H

    Food and nutrition Sciences   7 ( 1 )   19 - 30   2017年1月

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  • Development and evaluation of the Japanese version of the Audit of Diabetes-Dependent Quality of Life for patients with diabetes. 査読

    Ayumi Sugawara Hirose, Kazuya Fujihara, Flaminia Miyamasu, Shigeru Iwakabe, Misa Shimpo, Yoriko Heianza, Chika Horikawa, Yoko Yachi, Hirohito Sone

    Diabetology international   7 ( 4 )   384 - 390   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objectives: Our objective was to undertake linguistic validation and cultural adaptation of the Japanese version of the Audit of Diabetes-Dependent Quality of Life (JP-ADDQoL) and to evaluate its psychometric properties when completed by Japanese patients with diabetes. Methods: We followed the standard linguistic validation procedure and subsequently evaluated the reliability (internal consistency) and construct validity (exploratory and confirmatory factor analyses) of the translated version by surveying 239 Japanese patients with diabetes. Results: We translated 19 items for the JP-ADDQoL. The internal consistency was excellent (Cronbach's alpha = 0.933). In the exploratory factor analysis, four factors were extracted, and most of the items in all four factors had high loadings. Forced one-factor analysis revealed all factor loadings other than those for sex life to be >0.40 (sex life: 0.398). Confirmatory factor analysis indicated an acceptable fit for the JP-ADDQoL. Conclusions: The JP-ADDQoL showed adequate reliability and acceptable validity. Examining not only the impact of diabetes on a specific domain of life but also its importance for each patient leads to more accurate and individualized measurement of the patient's QoL.

    DOI: 10.1007/s13340-016-0260-4

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  • Quantitative assessment of genetic testing for type 2 diabetes mellitus based on findings of genome-wide association studies 査読

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    ANNALS OF EPIDEMIOLOGY   26 ( 11 )   816 - 818   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

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  • Utility of nonblood-based risk assessment for predicting type 2 diabetes mellitus: A meta-analysis 査読

    Sakiko Yoshizawa, Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Masahiro Ishizawa, Yasuhiro Matsubayashi, Satoshi Matsunaga, Takaho Yamada, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    PREVENTIVE MEDICINE   91   180 - 187   2016年10月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Objective. Nonblood-based risk assessment for type 2 diabetes mellitus (T2DM) that depends on data based on a questionnaire and anthropometry is expected to avoid unnecessary diagnostic testing and overdiagnosis due to blood testing. This meta-analysis aims to assess the predictive ability of nonblood-based risk assessment for future incident T2DM.
    Methods. Electronic literature search was conducted using EMBASE and MEDLINE (from January 1, 1997 to October 1, 2014). Included studies had to use at least 3 predictors for T2DM risk assessment and allow reproduction of 2 x 2 contingency table data (i.e., true positive, true negative, false positive, false negative) to be pooled with a bivariate random-effects model and hierarchical summary receiver-operating characteristic model. Considering the importance of excluding individuals with a low likelihood of T2DM from diagnostic blood testing, we especially focused on specificity and LR-.
    Results. Eighteen eligible studies consisting of 184,011 participants and 7038 cases were identified. The pooled estimates (95% confidence interval) were as follows: sensitivity = 0.73 (0.66-0.79), specificity = 0.66 (0.59-0.73), LR+ = 2.13 (1.81-2.50), and LR- = 0.41 (0.34-0.50).
    Conclusions. Nonblood-based assessment of risk of T2DM could produce acceptable results although the feasibility of such a screener needs to be determined in future studies. (C) 2016 Elsevier Inc. All rights reserved.

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  • Impact of individual components and their combinations within a family history of hypertension on the incidence of hypertension: Toranomon hospital health management center study 22 査読

    Risa Igarashi, Kazuya Fujihara, Yoriko Heianza, Masahiro Ishizawa, Satoru Kodama, Kazumi Saito, Shigeko Hara, Osamu Hanyu, Ritsuko Honda, Hiroshi Tsuji, Yasuji Arase, Hirohito Sone

    MEDICINE   95 ( 38 )   e4564   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Although a family history (FH) of hypertension is a risk factor for the development of hypertension, only a few studies have investigated in detail the impact of individual components of an FH on incident hypertension. We investigated the impact of individual components and their combinations on the presence or development of hypertension considering obesity, smoking habits, physical activity, and other metabolic parameters.Studied were 12,222 Japanese individuals without hypertension (n = 9,766) and with hypertension (n = 2,456) at the baseline examination. The presence or incidence of hypertension during 5 years after a baseline examination was assessed by the presence of systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg or a self-reported history of clinician-diagnosed hypertension. In this prospective study, the odds ratio for incident hypertension was 1.39 (95% confidence interval [CI], 1.22, 1.59) for individuals with any FH of hypertension compared with those without such an FH. Individuals with an FH of hypertension in both parents and one or more grandparents had an odds ratio of 3.05 (95% CI 1.74, 5.36) for hypertension compared with those without an FH of hypertension. FH was associated with incident hypertension independently of other modifiable risk factors such as obesity, smoking, physical inactivity, hyperglycemia, hyperuricemia, and hypertriglyceridemia.A parental history of hypertension was an essential component within an FH for incident hypertension. FH of hypertension over two generations with both parents affected was the most important risk factor for incident hypertension. Although an FH is not a modifiable risk factor, modifying other risk factors could contribute to reducing the risk of hypertension even among individuals with a family history of hypertension.

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  • Association of eating three meals irregularly with changes in BMI and weight among young Japanese men and women: A 2-year follow-up 査読

    Yoko Ibe, Happei Miyakawa, Yasuko Fuse-Nagase, Ayumi Sugawara Hirose, Reiko Hirasawa, Yoko Yachi, Kazuya Fujihara, Kazuto Kobayashi, Hitoshi Shimano, Hirohito Sone

    PHYSIOLOGY & BEHAVIOR   163   81 - 87   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Objective: Epidemiological longitudinal investigations of the association between not eating three meals regularly and changes in BMI and weight are scarce. The aim of this study was to investigate whether or not regularly eating three meals was associated with changes in BMI and weight in young Japanese men and women.
    Methods: Study participants were 1241 men and 897 women aged 19.0 +/- 12 and 18.8 +/- 0.8 years, respectively, who underwent health checkups at a university in Japan in 2001 as the baseline and subsequently in 2003. Weight and height were measured at baseline and 2 years later. Whether an individual ate three meals regularly was determined by a self-report questionnaire in 2001.
    Results: During the 2-year follow-up, the BMI gain was 0.347 for men and 0.067 for women. In the logistic regression analysis, for men, eating three meals irregularly was significantly associated with a 4% BMI gain (OR 1.60, CI 1.11-230), 6% BMI gain (OR 1.72, CI 1.12-2.63), 4 kg weight gain (OR 2.01, CI 1.29-3.13), 6 kg weight gain (OR 1.86, CI 1.02-337), and incidence of obesity (BMI &gt;= 25)(OR 2.96, CI 122-7.17). For women, eating three meals irregularly was significantly associated with a 4% BMI loss (OR 1.99, CI 1.01-3.94), 6% BMI loss (OR 2.79, CI 129-6.03), 4 kg weight loss (OR 3.85, CI 1.62-9.12), 6 kg weight loss (OR 7.65, CI 2.06-28.46), and the incidence of underweight (OR 3.95, CI 132-11.89).
    Conclusions: The current results suggested that eating three meals irregularly was associated with subsequent BMI and weight gains for men and subsequent BMI and weight losses for women; both groups were around 20 years of age. Self-reported eating behavior in this study might be used to screen and evaluate young Japanese men and women at high risk for changes in BMI and weight in a practical clinical setting. (C) 2016 Elsevier Inc All rights reserved.

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  • Serum malondialdehyde-modified LDL levels are increased in type 2 diabetic patients with nephropathy

    Suzuki, H, Furukawa, S, Fujihara, K, Kobayashi, K, Iwasaki, H, Yatoh, S, Sugano, Y, Sekiya, M, Yahagi, N, Yagyu, H, Shimano, H

    DIABETOLOGIA   59 ( 1 )   S538 - S538   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

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  • Body Mass Index (BMI), Waist Circumference (WC) and Waist Height Ratio (WHtR) Cutoff Values, and the Impact of Their Combinations on Future Diabetes among Japanese Individuals 査読

    Risa Igarashi, Kazuya Fujihara, Yoriko Heianza, Masahiro Ishizawa, Megumi Tsuruta, Mariko Hatta, Sakiko Yoshizawa, Chika Hirikawa, Satoshi Matsunaga, Osamu Hanyu, Satoru Kodama, Koji Sato, Kiminori Kato, Hirohito Sone

    DIABETES   65   A519 - A520   2016年6月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

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  • Comparison of clinical characteristics in patients with type2 diabetes among whom different antihyperglycemic agents were prescribed as monotherapy or combination therapy by diabetes specialists 査読

    Kazuya Fujihara, Osamu Hanyu, Yoriko Heianza, Akiko Suzuki, Takaho Yamada, Hiroki Yokoyama, Shiro Tanaka, Hiroaki Yagyu, Hitoshi Shimano, Atsunori Kashiwagi, Katuya Yamazaki, Koichi Kawai, Hirohito Sone

    JOURNAL OF DIABETES INVESTIGATION   7 ( 2 )   260 - 269   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Aims/IntroductionWe compared clinical characteristics in patients with type2 diabetes for whom different antihyperglycemic agents were prescribed as monotherapy or combination therapy by diabetes specialists in Japan.
    Materials and MethodsPrescription data for 2005, 2008 and 2011 from diabetes specialists' patient registries identified variables related to prescription of different antihyperglycemic agents.
    ResultsA total of 33,251 prescriptions in 2005, 25,119 in 2008 and 20,631 in 2011 were analyzed. Prescribing insulin was related to younger age, long duration of diabetes and glycated hemoglobin (HbA1c) 8.0%, but was negatively associated with obesity. Prescribing sulfonylureas was related to older age and long duration of diabetes, but not to obesity. Use of biguanides was related to younger age, short duration of diabetes and obesity, but was negatively associated with HbA1c 8.0%. A short duration of diabetes and HbA1c 8.0% were associated with use of a DPP-4 inhibitor, but not with obesity. Prescribing GLP-1 receptor agonists was related to younger age, obesity and HbA1c 8.0%. Odds ratios for each antihyperglycemic combination therapy were determined based on the characteristics of each included antihyperglycemic agent.
    ConclusionsThese results could be expected to reflect in part the consensus of diabetes specialists, and might provide guidance regarding pharmacotherapy in the clinical setting.

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  • Meta-analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus 査読

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    DIABETES-METABOLISM RESEARCH AND REVIEWS   32 ( 2 )   178 - 186   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    BackgroundOur aim is to examine the dose-response association between cumulative genetic risk and actual risk of type 2 diabetes mellitus (T2DM) and the influence of adjustment for covariates on T2DM risk through a comprehensive meta-analysis of observational studies.
    MethodsElectronic literature search using EMBASE and MEDLINE (from 2003 to 2014) was conducted for cross-sectional or longitudinal studies that presented the odds ratio (OR) for T2DM in each group with categories based on the total number of risk alleles (RAs) carried (RA(total)) using at least two single-nucleotide polymorphisms. Spline regression model was used to determine the shape of the relationship between the difference from the referent group of each study in RA(total) (RA(total)) and the natural logarithms of ORs (log OR) for T2DM.
    ResultsSixty-five eligible studies that included 68267 cases among 182603 participants were analysed. In both crude and adjusted ORs, defined by adjusting the risk for at least two confounders among age, gender and body mass index, the slope of the log OR for T2DM became less steep as the RA(total) increased. In the analysis limited to 14 cross-sectional and four longitudinal studies presenting both crude and adjusted ORs, regression curves of both ORs in relation to RA(total) were almost identical.
    ConclusionUsing only single-nucleotide polymorphisms for T2DM screening was of limited value. However, when genotypic T2DM risk was considered independently from risk in relation to covariates, it was suggested that genetic profiles might have a supplementary role related to conventional T2DM risk factors in identifying individuals at high risk of T2DM. Copyright (c) 2015 John Wiley & Sons, Ltd.

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  • Meta-analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus. 査読 国際誌

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

    Diabetes/metabolism research and reviews   32 ( 2 )   178 - 86   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Our aim is to examine the dose-response association between cumulative genetic risk and actual risk of type 2 diabetes mellitus (T2DM) and the influence of adjustment for covariates on T2DM risk through a comprehensive meta-analysis of observational studies. METHODS: Electronic literature search using EMBASE and MEDLINE (from 2003 to 2014) was conducted for cross-sectional or longitudinal studies that presented the odds ratio (OR) for T2DM in each group with categories based on the total number of risk alleles (RAs) carried (RAtotal ) using at least two single-nucleotide polymorphisms. Spline regression model was used to determine the shape of the relationship between the difference from the referent group of each study in RAtotal (ΔRAtotal ) and the natural logarithms of ORs (log OR) for T2DM. RESULTS: Sixty-five eligible studies that included 68 267 cases among 182 603 participants were analysed. In both crude and adjusted ORs, defined by adjusting the risk for at least two confounders among age, gender and body mass index, the slope of the log OR for T2DM became less steep as the ΔRAtotal increased. In the analysis limited to 14 cross-sectional and four longitudinal studies presenting both crude and adjusted ORs, regression curves of both ORs in relation to ΔRAtotal were almost identical. CONCLUSION: Using only single-nucleotide polymorphisms for T2DM screening was of limited value. However, when genotypic T2DM risk was considered independently from risk in relation to covariates, it was suggested that genetic profiles might have a supplementary role related to conventional T2DM risk factors in identifying individuals at high risk of T2DM. Copyright © 2015 John Wiley & Sons, Ltd.

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  • In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis 査読

    Hajime Ishiguro, Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Ayumi Sugawara Hirose, Reiko Hirasawa, Yoko Yachi, Nobumasa Ohara, Hitoshi Shimano, Osamu Hanyu, Hirohito Sone

    SPORTS MEDICINE   46 ( 1 )   67 - 77   2016年1月

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    記述言語:英語   出版者・発行元:ADIS INT LTD  

    Background Resistance training (RT) is effective for glycemic control in type 2 diabetes mellitus (T2DM) patients. However, the characteristics of an RT program that will maximize its effect and those of patients that will especially benefit from RT are unknown.
    Objective The objectives of this systematic review were to identify via a comprehensive meta-analysis the characteristics of an RT program for patients with T2DM that might increase the patients' improvement in glycemic control and the characteristics of patients that will benefit from RT. Data Sources Electronic-based literature searches of MEDLINE and EMBASE entries from 1 January 1966 to 25 August 2014 were conducted to identify clinical trials examining the effect of RT on glycemic control among patients with T2DM. Study keywords were text words and thesaurus terms related to RT and T2DM.
    Study Selection Studies were included if they (1) were clinical trials consisting of two groups with and without RT exercise intervention; (2) had an intervention period of at least 5 weeks; (3) clarified that all patients had T2DM; and (4) reported or made it possible to estimate the effect size [i.e., change in glycosylated hemoglobin (HbA1c) in the RT group minus that in the control group] and its corresponding standard error.
    Study Appraisal and Synthesis Methods The effect size in each study was pooled with a random-effects model. Analyses were stratified by several key characteristics of the patients and RT exercise programs; meta-regression analysis was then used to detect a difference in the effect size among strata within each factor. Linear regression analyses were added by entering each of the following profiles: patients' baseline characteristics [mean baseline age, body mass index (BMI), and HbA1c levels] and exercise characteristics (total sets per week, total sets per bout of exercise, frequency, and intensity).
    Results There were 23 eligible studies comprising 954 patients with T2DM. The pooled effect size (95 % confidence interval) was -0.34 % (-0.53 to -0.16). A program with multiple sets (&gt;= 21 vs. &lt;21) per one RT bout was associated with a large effect size (P = 0.03); however, the linear correlation between the number of sets and effect size was not significant (P = 0.56). A larger effect size was observed in studies with participants with diabetes of a relatively short duration (&lt;6 vs. &gt;= 6 years; P = 0.04) or a high baseline HbA(1c) [&gt;= 7.5 % (58 mmol/mol) vs. &lt;7.5 %; P = 0.01] while a smaller effect size was observed in studies with a particularly high mean baseline BMI value (&gt;= 32 vs. &lt;32 kg/m(2); P = 0.03). Linear regression analyses predicted that each increment of 1 % in the baseline HbA(1c) would enlarge the effect size by 0.036 %, while each increment of 1 kg/m(2) in the baseline BMI decreased it by 0.070 % in the range between 22.3 and 38.8 kg/m(2).
    Conclusion In terms of glycemic control, RT could be recommended in the early stage of T2DM, especially for patients with relatively poor glycemic control. More benefit would be elicited in less obese patients within a limited range of the BMI. A substantial amount of exercise might be required to stimulate post-exercise glucose uptake, although the dose-dependency was not specifically clarified.

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  • Fulminant Type 1 Diabetes Mellitus Presenting 11 Days after Delivery in a Patient of Mixed Genetic Background 査読

    Shoko Furukawa, Kazuya Fujihara, Ryo Kumagai, Momoko Isono, Hiroaki Yagyu

    INTERNAL MEDICINE   55 ( 14 )   1881 - 1885   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    The patient was a 25-year-old woman whose paternal family was Japanese, maternal grandfather was Filipino, and maternal grandmother was Chinese. Eleven days after delivery, she presented with excessive thirst and disturbed consciousness due to diabetic ketoacidosis. She was diagnosed as having fulminant type 1 diabetes associated with pregnancy (PF). The antibody concentration against glutamic acid decarboxylase was 1.2 (&lt;1.5) U/mL, and human leukocyte antigen (HLA) class II haplotypes were DRB1*04:10-DQB1*03: 02 and DRB1*15: 02-DQB1*05:01. The present case had unique HLA class II haplotypes that have not been previously reported in association with PF.

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  • Pioglitazone-induced Pulmonary Injury in a Very Elderly Patient 査読

    Kohta Katayama, Ryo Kumagai, Momoko Isono, Kazuya Fujihara, Hiroaki Yagyu, Gen Ohara, Katsunori Kagohashi, Hiroaki Satoh

    INTERNAL MEDICINE   55 ( 13 )   1779 - 1782   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    An 85-year-old woman with diabetes mellitus was admitted to our hospital due to progressive dyspnea. Two months previously, pioglitazone had been newly prescribed for diabetes management. Bilateral ground-glass opacities and progressive respiratory deterioration suggested respiratory failure due to a drug-induced lung injury. With discontinuation of pioglitazone and the administration of a corticosteroid, an improvement in her respiratory condition was achieved, although sequelae remained in some areas of the lungs. Results of drug-induced lymphocyte stimulation tests were positive for pioglitazone. Resumption of other drugs did not reinduce the lung injury. Therefore, a diagnosis of pioglitazone-induced lung injury was made. Although pioglitazone-induced lung injury is very rare, clinicians should keep it in mind when pioglitazone is used.

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  • Simple self-reported behavioral or psychological characteristics as risk factors for future type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 14 査読

    Yoriko Heianza, Yasuji Arase, Satoru Kodama, Hiroshi Tsuji, Kazuya Fujihara, Kazumi Saito, Shigeko Hara, Hirohito Sone

    JOURNAL OF DIABETES INVESTIGATION   6 ( 2 )   236 - 241   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Aims/IntroductionDepression, anger, sleep disorders and cognitive impairment are regarded as presenting a high risk for diabetes. We investigated whether responses to single statements on a self-report questionnaire on the presence of each of these four factors were associated with the development of type 2 diabetes.
    Materials and MethodsWe investigated 3,211 Japanese individuals without diabetes. Cumulative incidence rate and hazard ratios (HRs) for future type 2 diabetes over 7-13years were evaluated according to the presence of lack of perseverance, anger, memory loss or sleep disorders.
    ResultsResults of Cox regression analysis showed that lack of perseverance (age- and sex-adjusted HR 1.41, 95% confidence interval 1.07-1.84), anger, (HR 1.51, 95% confidence interval 1.07-2.12) or memory loss (HR 1.47, 95% confidence interval 1.14-1.90) was predictive of the development of diabetes. Even after adjustment for metabolic factors including glycemic measurements, anger was significantly associated with an increased risk of future diabetes. Individuals with both anger and memory loss had a 1.94-fold (95% confidence interval 1.19-3.15) increased risk of type2 diabetes than those without those two symptoms.
    ConclusionsResponses to a simple self-report questionnaire as to whether individuals were aware of anger or memory loss were associated with the development of type2 diabetes independent of traditional risk factors for diabetes in this cohort of Japanese individuals.

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  • Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes 査読

    Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hiroaki Yagyu, Hirohito Sone, Hitoshi Shimano

    JOURNAL OF DIABETES RESEARCH   2015   507245   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI PUBLISHING CORPORATION  

    Aims. To elucidate the levels of malondialdehyde-modified LDL (MDA-LDL)-related variables for predicting coronary artery stenosis (CAS) by coronary CT angiography (CCTA) in asymptomatic patients with type 2 diabetes (T2DM). Methods. Enrolled were 36 Japanese patients with T2DM who underwent CCTA and in whom MDA-LDL levels were measured. Definition of CAS was luminal narrowing of &gt;= 50%. Trends through tertiles of each MDA-LDL-related variable were analyzed with a general linear model. The ability of each MDA-LDL-related variable to predict CAS was compared to areas under the curve (AUCs) in receiver operating characteristic curve (ROC) analysis. Results. Seventeen patients had CAS. Each MDA-IDL-related variable was an independent predictor of CAS (P = 0.039 for MDALDL, P = 0.013 for MDA-LDL/LDL-C, P = 0.047 for MDA-LDL/HDL-C, and P = 0.013 for (MDA-LDULDL-C)/HDL-C). AUCs of MDA-LDL, MDA-LDL/LDL-C, MDA-LDL/HDL-C, and (MDA-LDULDLC)/HDL-C were 0.675 (95% CI 0.496-0.854), 0.765 (0.602-0.927), 0.752 (0.592-0.913), and 0.799 (0.643-0.955), respectively, for predicting CAS. Trends throughout the tertiles showed significant associations between N4DA-LDL/LDL-C, N4DA-LDL/41DL-C, or (MDALDL/LDL-C)/41DL-C and CAS (P 0.003 for MDA-LDL/LDL-C, P=0.042 for MDA-LDULIDL-C, and P 0.001 for (MDA-LDULDL-C)/HDL-C). Conclusions. Data suggest that measurements of MDA-LDL/LDL-C, MDA-LDL/HDLC, and (MakLDULDL-C)/HDL-C are useful for predicting CAS.

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  • Impact on short-term glycaemic control of initiating diabetes care versus leaving diabetes untreated among individuals with newly screening-detected diabetes in Japan 査読

    Yoriko Heianza, Akiko Suzuki, Kazuya Fujihara, Shiro Tanaka, Satoru Kodama, Osamu Hanyu, Hirohito Sone

    JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH   68 ( 12 )   1189 - 1195   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ PUBLISHING GROUP  

    Background The impact of early initiation of diabetes care soon after the identification of hyperglycaemia rather than leaving diabetes untreated on changes in glycaemic control has not been fully clarified. We aimed to quantify the effect of initiating and continuing diabetes care compared with not starting management of diabetes on short-term changes in glycaemic control among the Japanese with newly screening-detected diabetes.
    Methods We retrospectively reviewed data from a nationwide claims database to assess histories of physician-diagnosed diabetes or hyperglycaemia, as well as the use of antidiabetic agents, blood testing for hyperglycaemia or dietary advice among individuals without a history of diabetes care. Changes in glycated haemoglobin (HbA1c) concentrations were evaluated using baseline data and data from a health examination during the following year.
    Results Among 1393 individuals with newly screening-detected diabetes, 62% (n=864) did not initiate diabetes management during the follow-up period; 49.2% (n=425) of the untreated group had poor glycaemic control (HbA1c =7%) at the baseline examination. Only 38% (n=529) began diabetes management in medical settings. Individuals who remained untreated had a 1.87 (95% CI 1.38 to 2.52) or 1.63 (1.10 to 2.41) times higher risk of absolute increases in HbA1c &gt;= 0.5% or &gt;= 1%, respectively, compared with the treated patients, a difference that was significant. Making more frequent clinic visits especially after the first visit was dose-dependently associated with improved HbA1c levels compared with no diabetes management.
    Conclusions In comparison with a lack of management of diabetes, immediately initiating and continuing diabetes care after identification of hyperglycaemia in a screening setting would contribute to clinically meaningful, improved glycaemic control in the Japanese.

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  • High cholesterol intake is associated with elevated risk of type 2 diabetes mellitus - A meta-analysis(1-4) 査読

    Ryoko Tajima, Satoru Kodama, Miho Hirata, Chika Horikawa, Kazuya Fujihara, Yoko Yachi, Sakiko Yoshizawa, Kaoruko Tada Iida, Hirohito Sone

    CLINICAL NUTRITION   33 ( 6 )   946 - 950   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CHURCHILL LIVINGSTONE  

    Background & aims: Some foods rich in cholesterol are associated with high risk of type 2 diabetes (T2D). To confirm the association between dietary cholesterol intake and T2D risk, we performed a meta-analysis of observational studies.
    Methods: We searched for longitudinal studies that provided data on the relative risk (RR) for T2D in relation to the cholesterol intake level using MEDLINE (from 1950 for July 10, 2013) and EMBASE (from 1974 to July 10, 2013). The RR for the highest vs. lowest cholesterol intake category or for an increment of 100 mg/day in cholesterol consumption was pooled with an inverse-variance method.
    Results: Five studies met the inclusion criteria. Compared with the lowest category, the highest category had a significantly higher association with T2D risk (RR [95% confidence interval (CI)], 1.25 [1.16-1.36]). The pooled RR for a 100-mg/day increment was also significant (RR [95% CI], 1.11 [1.06-1.15]).
    Conclusion: Current meta-analysis suggested that high intake of cholesterol was positively associated with future T2D risk. (C) 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

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  • Role of sleep duration as a risk factor for Type 2 diabetes among adults of different ages in Japan: the Niigata Wellness Study. 査読

    Diabet Med   31 ( 11 )   1363 - 1367   2014年11月

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    記述言語:英語  

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  • High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis 査読

    Chika Horikawa, Saroru Kodama, Kazuya Fujihara, Reiko Hirasawa, Yoko Yachi, Akiko Suzuki, Osamu Hanyu, Hitoshi Shimano, Hirohito Sone

    DIABETES RESEARCH AND CLINICAL PRACTICE   106 ( 1 )   81 - 87   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Aims: Eradication of Helicobacter pylori (HP) is an effective approach to improve intestinal symptoms and prevent gastric cancer. However, there has been concern that the presence of diabetes reduces the effectiveness of antibiotics. We performed this meta-analysis to investigate the effect of diabetes on the risk of failing eradication in patients with diabetes.
    Methods: An electronic literature search was conducted using Biosis, MEDLINE, Embase, PASCAL, and SciSearch through November 30, 2012. Selected studies had to provide data on the number of individuals who received treatment for HP infection and on the failure of HP eradication in groups with and without diabetes. Two authors independently extracted relevant data.
    Results: Data were obtained from 8 eligible studies (693 total participants including 273 participants with diabetes). Overall, the pooled risk ratio (RR) of failing HP eradication for diabetic patients compared with non-diabetic participants was 2.19 [95% CI, 1.65-2.90] (P &lt; 0.001). Excluding the 2 studies that used a non-standard protocol for HP eradication, individuals with diabetes had a higher risk of failure of eradication compared to those without diabetes (RR = 2.31 [95% CI, 1.72-3.11]).
    Conclusions: Current meta-analysis confirmed the higher risk of HP eradication failure in individuals with diabetes compared with those without diabetes, suggesting the necessity of prolonging treatment or developing a new regimen for HP eradication in patients with diabetes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

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  • Second trimester postload glucose level as an important predictor of low birth weight infants: Tanaka Women's Clinic Study 査読

    Yoko Yachi, Yasuhiro Tanaka, Izumi Nishibata, Sakiko Yoshizawa, Kazuya Fujihara, Satoru Kodama, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

    DIABETES RESEARCH AND CLINICAL PRACTICE   105 ( 3 )   E16 - E19   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Although it is well known that the maternal prepregnancy BMI is a strong contributor to fetal growth, our results showed that a low postload glucose level, although within normal range, independent of maternal BMI was strongly associated with an increased risk of low birth weight births among Japanese mothers. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

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  • Metabolically Healthy Obesity, Presence or Absence of Fatty Liver, and Risk of Type 2 Diabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20) 査読

    Yoriko Heianza, Yasuji Arase, Hiroshi Tsuji, Kazuya Fujihara, Kazumi Saito, Shiun Dong Hsieh, Shiro Tanaka, Satoru Kodama, Shigeko Hara, Hirohito Sone

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   99 ( 8 )   2952 - 2960   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ENDOCRINE SOC  

    Objective: We investigated whether the metabolically healthy obese (MHO) phenotype was associated with an increased risk of the development of diabetes. If so, we aimed to determine what factors could explain this finding.
    Design, Setting, and Participants: Studied were 8090 Japanese individuals without diabetes. Metabolic health status was assessed by common clinical markers: blood pressure, triglycerides, high-density lipoprotein-cholesterol, and fasting glucose concentrations. The cutoff value for obesity or normal weight (NW) was a body mass index of 25.0 kg/m(2).
    Results: The 5-year incidence rate of diabetes was 1.2% (n = 58 of 4749) in metabolically healthy NW (MHNW) individuals, 2.8% (n = 20 of 719) in MHO individuals, 6.0% (n = 102 of 1709) in metabolically abnormalNWindividuals, and 10.3%(n = 94 of 913) in metabolically abnormal obese individuals. Although MHO individuals had no or one metabolic factor, 47.8% had ultrasonographic fatty liver (FL). The MHO group had a significantly increased risk of diabetes compared with the MHNW group [multivariate adjusted odds ratio (OR) 2.23 (95% confidence interval [CI] 1.33, 3.75)], but this risk was attenuated after adjustment for FL. Compared with the MHNW/non-FL group, the risk of diabetes in the MHO/non-FL group was not significantly elevated [OR 1.01 (95% CI 0.35, 2.88)]. However, the MHO/FL and MHNW/FL groups had similarly elevated risks of diabetes [OR 4.09 (95% CI 2.20, 7.60) and 3.16 (1.78, 5.62), respectively].
    Conclusions: Almost half of the MHO participants had FL, which partially explained the increased risk of diabetes among the obese phenotypes. The presence of FL should be evaluated to assess whether an individual was actually in a metabolically benign state for the prediction of diabetes.

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  • Quantitative relationship between body weight gain in adulthood and incident type 2 diabetes: a meta-analysis. 査読 国際誌

    Kodama S, Horikawa C, Fujihara K, Yoshizawa S, Yachi Y, Tanaka S, Ohara N, Matsunaga S, Yamada T, Hanyu O, Sone H

    Obesity review   15 ( 3 )   202 - 214   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Meta-Analysis of the Quantitative Relation Between Pulse Pressure and Mean Arterial Pressure and Cardiovascular Risk in Patients With Diabetes Mellitus 査読

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Sakiko Yoshizawa, Yoko Yachi, Shiro Tanaka, Nobumasa Ohara, Satoshi Matsunaga, Takaho Yamada, Osamu Hanyu, Hirohito Sone

    AMERICAN JOURNAL OF CARDIOLOGY   113 ( 6 )   1058 - 1065   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC  

    Results of epidemiologic studies that investigated the significance of pulse pressure (PP) and mean arterial pressure (MAP) in terms of risk of cardiovascular disease (CVD) in patients with diabetes mellitus are inconsistent. We performed a quantitative meta-analysis to estimate CVD risk in relation to PP or MAP. Electronic literature search was conducted for prospective studies providing data on CVD risk for an increment in baseline MAP or PP in patients with diabetes mellitus. The pooled CVD risk for a 10-mm Hg increase in each blood pressure (BP) index was estimated with a random-effects model. There were 17 eligible studies consisting of 52,647 patients and 5,112 CVD cases. The pooled relative risk (95% confidence interval) of CVD for an increment of 10 mm Hg was 1.10 (1.04 to 1.16) for PP and 1.09 (0.98 to 1.21) for MAP. Significant between-study heterogeneity was observed (I-2 [p value]; 76.5% [p &lt; 0.001] for PP, 67.8% [p = 0.005] for MAP). In studies concurrently investigating CVD risk for the 4 indexes (i.e., PP, MAP, systolic BP, and diastolic BP), the pooled relative risk (95% confidence interval) was 1.17 (1.09 to 1.26) for PP, 1.11 (1.06 to 1.15) for MAP, 1.14 (1.06 to 1.22) for systolic BP, and 1.06 (0.94 to 1.19) for diastolic BP. In conclusion, the current meta-analysis suggested that PP was the strongest indicator among the 4 commonly used BP indexes. However, the large heterogeneity urged cautious interpretation of the study results. (c) 2014 Elsevier Inc. All rights reserved.

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  • Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis 査読

    Chika Horikawa, Satoru Kodama, Kazuya Fujihara, Yoko Yachi, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Hitoshi Shimano, Hirohito Sone

    JOURNAL OF DIABETES RESEARCH   2014   250620   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI PUBLISHING CORPORATION  

    Objective. To assess the association between Helicobacter pylori (HP) infection and glycemic control in patients with diabetes through a meta-analytic approach. Research Design and Methods. Electronic literature searches were conducted for cross-sectional studies that examined the hemoglobin A1c (A1C) level by whether patients with diabetes were or were not carriers of HP. Mean differences in A1C between groups with and without HP infection were pooled with a random-effects model. Results. Thirteen eligible studies were included in this meta-analysis. Overall, the HP carriers did not have significantly higher A1C levels compared with HP noncarriers (mean difference (95% CI), 0.19% (-0.18 to 0.46), P = 0.16). When the analysis was limited to studies targeting patients with type 1 diabetes, there was also no significant difference in A1C (0.69% (-0.31 to 1.68), P = 0.18). Conclusions. There was insufficient evidence that HP infection worsened glycemic control in patients with diabetes.

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  • Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study 査読

    Kazuya Fujihara, Ayumi Sugawara, Yoriko Heianza, Toshimi Sairenchi, Fujiko Irie, Hiroyasu Iso, Mikio Doi, Hitoshi Shimano, Hiroshi Watanabe, Hirohito Sone, Hitoshi Ota

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   21 ( 11 )   1152 - 1169   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN ATHEROSCLEROSIS SOC  

    Aim: The levels of lipids, especially triglycerides (TG), and obesity are associated with diabetes mellitus (DM). Although typically measured in fasting individuals, non-fasting lipid measurements play an important role in predicting future DM. This study compared the predictive efficacy of lipid variables according to the fasting status and body mass index (BMI) category.
    Methods: Data were collected for 39,196 nondiabetic men and 87,980 nondiabetic women 40-79 years of age who underwent health checkups in Ibaraki-Prefecture, Japan in 1993 and were followed through 2007. The hazard ratios (HRs) for DM in relation to sex, the fasting status and BMI were estimated using a Cox proportional hazards model.
    Results: A total of 8,867 participants, 4,012 men and 4,855 women, developed DM during a mean follow-up of 5.5 years. TG was found to be an independent predictor of incident DM in both fasting and non-fasting men and non-fasting women. The multivariable-adjusted HR for DM according to the TG quartile (Q) 4 vs. Q1 was 1.18 (95% confidence interval (CI): 1.05, 1.34) in the non-fasting men with a normal BMI (18.5-24.9). This trend was also observed in the non-fasting women with a normal BMI. That is, the multivariable-adjusted HRs for DM for TG Q2, Q3 and Q4 compared with Q1 were 1.07 (95% CI: 0.94, 1.23), 1.17 (95% CI: 1.03, 1.34) and 1.48 (95% CI: 1.30, 1.69), respectively.
    Conclusions: The fasting and non-fasting TG levels in men and non-fasting TG levels in women are predictive of future DM among those with a normal BMI. Clinicians must pay attention to those individuals at high risk for DM.

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  • Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes 査読

    Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Tomoko Ishizu, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hirohito Sone, Hitoshi Shimano

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   21 ( 8 )   799 - 815   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN ATHEROSCLEROSIS SOC  

    Aims: To compare the efficacy of Framingham Risk Score (FRS), UK Prospective Diabetes Study (UKPDS) risk engine, a risk score based on the Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC), the maximum intima-media thickness (max-IMT) determined on coronary computed tomography angiography (CCTA) and their combination in asymptomatic patients with type 2 diabetes.
    Methods: A total of 116 Japanese patients with type 2 diabetes underwent CCTA. The risk of coronary heart disease was calculated according to the FRS, UKPDS and JALS-ECC. We evaluated the reclassification of coronary artery stenosis (CAS) based on the risk score categories after adding each IMT related variable.
    Results: Sixty-eight patients had CAS. The areas under the curves (AUCs) in the receiver operating characteristic curve analyses of FRS, UKPDS and JALS-ECC were 0.763 (95% confidence interval [CI]: 0.674-0.853), 0.785 (95% CI: 0.703-0.868) and 0.767 (95% CI: 0.681-0.853), respectively. The AUCs for FRS, UKPDS and JALS-ECC combined with the max-IMT were 0.788 (95% CI: 0.705-0.872), 0.800 (95% CI: 0.720-0.879) and 0.786 (95% CI: 0.703-0.869), respectively. Combining the max-IMT with the risk scores improved the identification of subjects with stenotic lesions, in particular, those in the first, second and third tertiles of the FRS, first and second tertiles of the UKPDS and first and second tertiles of the JALS-ECC (P=0.054, P=0.056, P=0.015, P=0.082, P=0.060, P=0.007, and P=0.080, respectively). The net reclassification improvement increased following the addition of a max-IMT of &gt;= 1.9 mm (32.4% in FRS, 19.9% in UKPDS and 51.7% in JALS-ECC).
    Conclusions: These data suggest that combining a risk score with the max-IMT improves the prediction of CAS in comparison with the risk score alone.

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  • Use of high-normal levels of haemoglobin A(1C) and fasting plasma glucose for diabetes screening and for prediction: a meta-analysis. 査読 国際誌

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Reiko Hirasawa, Yoko Yachi, Sakiko Yoshizawa, Shiro Tanaka, Yasuko Sone, Hitoshi Shimano, Kaoruko Tada Iida, Kazumi Saito, Hirohito Sone

    Diabetes/metabolism research and reviews   29 ( 8 )   680 - 92   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Using high-normal levels of haemoglobin A1C (Abnormal-A1C ) or fasting plasma glucose (FPG) (Abnormal-FPG) for diabetes screening are expected to improve the ability to detect persons with or at high risk of diabetes. We assessed the diagnostic and predictive capacity for diabetes of Abnormal-A1C and Abnormal-FPG. We compared these to the combined use of the two measures to the single use of either measurement. METHODS: We analysed 31 eligible cross-sectional or cohort studies that assessed diagnostic or predictive ability, respectively, by using lower A1C and FPG cutoff values than recommended by current diabetes criteria. Positive and negative likelihood ratios (LR+ and LR-) were calculated to assess the ability to confirm or exclude diabetes, respectively, on the basis of a bivariate random-effects model. RESULTS: With both Abnormal-A1C and Abnormal-FPG, the pooled LR+ was above 4 for diagnosing diabetes and above 3 for predicting diabetes. However, the pooled LR- for predicting diabetes was higher with Abnormal-A1C (0.48) and Abnormal-FPG (0.49) in comparison with that for diagnosing diabetes (0.27, Abnormal-A1C ; 0.28, Abnormal-FPG). In eight studies that assessed the predictive ability of the combination of A1C and FPG, using either Abnormal-A1C or Abnormal-FPG could lower LR- to 0.17 from 0.43 for only Abnormal-A1C and from 0.38 for only Abnormal-FPG. Accordingly, LR+ was also lowered to 2.37 from 3.36 for only Abnormal-A1C and from 3.84 for only-Abnormal-FPG. CONCLUSION: The use of the two blood glucose tests had insufficient capacity to identify subjects at high risk for diabetes but had considerable capacity to identify undiagnosed diabetes.

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  • Body Weight Change and Type 2 Diabetes 査読

    Satoru Kodama, Chika Horikawa, Sakiko Yoshizawa, Kazuya Fujihara, Yoko Yachi, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Hiroaki Yagyu, Hirohito Sone

    EPIDEMIOLOGY   24 ( 5 )   778 - 779   2013年9月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1097/EDE.0b013e31829f6c31

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  • Role of alcohol drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS 11) 査読

    Yoriko Heianza, Yasuji Arase, Kazumi Saito, Hiroshi Tsuji, Kazuya Fujihara, Shiun Dong Hsieh, Satoru Kodama, Hitoshi Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

    AMERICAN JOURNAL OF CLINICAL NUTRITION   97 ( 3 )   561 - 568   2013年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER SOC NUTRITION-ASN  

    Background: Findings of past studies on the effect of drinking patterns on diabetes risk have been inconsistent.
    Objective: We aimed to investigate the role of drinking frequency and usual quantity consumed in the development of type 2 diabetes.
    Design: Enrolled were 1650 Japanese men without diabetes (diabetes: fasting plasma glucose &gt;= 7.0 mmol/L, glycated hemoglobin &gt;= 6.5%, or self-reported clinician-diagnosed diabetes). Average alcohol consumption and 12 combinations of frequency and usual quantity per drinking occasion were assessed at the baseline examination. The absolute risk and HR for the development of diabetes were calculated.
    Results: During a mean follow-up period of 10.2 y, 216 individuals developed diabetes. Lifetime abstainers (n = 153) had a relatively low incidence of diabetes (9.1/1000 person-years), similar to moderate consumers (99-160 g ethanol/wk; 9.0/1000 person-years). Increasingly higher quantities of alcohol usually consumed per occasion increased the risk of diabetes regardless of drinking frequency. The lowest incidence rate of diabetes (8.5/1000 person-years) was associated with the consumption of &lt;1 drink (&lt;23 g ethanol) per occasion over &gt;= 6 times/wk. Binge drinking (&gt;= 3 drinks per occasion) significantly increased the risk of future diabetes regardless of frequency (HR: 1.79; 95% CI: 1.17, 2.74) compared with &lt;1 drink per occasion.
    Conclusions: Among current drinkers, a drinking pattern of &lt;1 drink per occasion regularly over 6 times within a week was associated with the lowest risk of developing diabetes. Usual quantity per drinking occasion was a more important determinant than was weekly drinking frequency in the association between alcohol consumption and risk of diabetes in Japanese men. Am J Clin Nutr 2013;97:561-8.

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  • Association Between Physical Activity and Risk of All-Cause Mortality and Cardiovascular Disease in Patients With Diabetes A meta-analysis 査読

    Satoru Kodama, Shiro Tanaka, Yoriko Heianza, Kazuya Fujihara, Chika Horikawa, Hitoshi Shimano, Kazumi Saito, Nobuhiro Yamada, Yasuo Ohashi, Hirohito Sone

    DIABETES CARE   36 ( 2 )   471 - 479   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER DIABETES ASSOC  

    OBJECTIVE-The association between habitual physical activity (PA) and lowered risk of all-cause mortality (ACM) and cardiovascular disease (CVD) has been suggested in patients with diabetes. This meta-analysis summarizes the risk reduction in relation to PA, focusing on clarifying dose-response associations.
    RESEARCH DESIGN AND METHODS-Electronic literature searches were conducted for cohort studies that examined relative risk (RR) of ACM or CVD in relation to PA in patients with diabetes. For the qualitative assessment, RR for the highest versus the lowest PA category in each study was pooled with a random-effects model. We added linear and spline regression analyses to assess the quantitative relationship between increases in PA and ACM and CVD risk.
    RESULTS-There were 17 eligible studies. Qualitatively, the highest PA category had a lower RR [95% CI] for ACM (0.61 [0.52-0.70]) and CVD (0.71 [0.60-0.84]) than the lowest PA category. The linear regression model indicated a high goodness of fit for the risk of ACM (adjusted R-2 = 0.44, P = 0.001) and CVD (adjusted R-2 = 0.51, P = 0.001), with the result that a 1 MET-h/day incrementally higher PA was associated with 9.5% (5.0-13.8%) and 7.9% (4.3-11.4%) reductions in ACM and CVD risk, respectively. The spline regression model was not significantly different from the linear model in goodness of fit (P = 0.14 for ACM risk; P = 0.60 for CVD risk).
    CONCLUSIONS-More PA was associated with a larger reduction in future ACM and CVD risk in patients with diabetes. Nevertheless, any amount of habitual PA was better than inactivity. Diabetes Care 36:471-479, 2013

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  • Diabetes and Risk of Hearing Impairment in Adults: A Meta-Analysis 査読

    Chika Horikawa, Satoru Kodama, Shiro Tanaka, Kazuya Fujihara, Reiko Hirasawa, Yoko Yachi, Hitoshi Shimano, Nobuhiro Yamada, Kazumi Saito, Hirohito Sone

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   98 ( 1 )   51 - 58   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ENDOCRINE SOC  

    Context: Recently, several studies have investigated the relationship between diabetes and hearing impairment, but results were inconsistent.
    Objective: Our objective was to compare the prevalence of hearing impairment between diabetic and nondiabetic adults. Data Sources : We performed a systematic literature search using MEDLINE (1950 to May 30, 2011) and EMBASE (1974 to May 30, 2011).
    Study Selection: Cross-sectional studies were included if data on numbers of hearing-impaired and non-hearing-impaired cases with diabetes were presented. Hearing impairment was limited to that assessed by pure-tone audiometry that included at least 2 kHz of frequency range and was defined as progressive, chronic, sensorineural, or without specified cause.
    Data Extraction: Two authors independently extracted relevant data. Odd ratios (ORs) of hearing impairment related to diabetes calculated in each study were pooled with the random-effects model.
    Data Synthesis: Data were obtained from 13 eligible studies (20,194 participants and 7,377 cases). Overall pooled OR (95% confidence interval) of hearing impairment for diabetic participants compared with nondiabetic participants was 2.15 (1.72-2.68). OR was higher in younger participants (mean age, &lt;= 60 yr) than in those over 60 yr among which the OR remained significant (2.61 and 1.58, P = 0.008). The strength of the association between diabetes and prevalence of hearing impairment was not significantly influenced by whether participants were matched for age and gender (P = 0.68) or whether participants chronically exposed to noisy environments were excluded (P = 0.19).
    Conclusions: Current meta-analysis suggests that the higher prevalence of hearing impairment in diabetic patients compared with nondiabetic patients was consistent regardless of age. (J Clin Endocrinol Metab 98: 51-58, 2013)

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  • Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus 査読

    Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Nobuhiro Yamada, Hirohito Sone, Hitoshi Shimano

    Journal of Atherosclerosis and Thrombosis   20 ( 5 )   452 - 464   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims: To investigate the clinical predictors of coronary atherosclerosis and to assess the utility of maximum-IMT for predicting coronary atherosclerosis in asymptomatic type 2 diabetic patients. Methods: One hundred one Japanese patients with type 2 diabetes underwent computed tomography coronary angiography. Definitions of coronary artery stenosis and vulnerable coronary plaque were luminal narrowing of ≥50% and any coronary plaque with positive vessel remodeling and low attenuation, respectively. Carotid intima-media thickness (IMT) was assessed using B-mode ultrasound. Results: Of the 101 patients, 40 had coronary artery stenosis without vulnerable coronary plaque, 7 had vulnerable coronary plaque without coronary artery stenosis, and 23 had coronary artery stenosis with vulnerable coronary plaque. Male sex (p= 0.031), duration of diabetes (p= 0.024), systolic blood pressure (SBP) (p=0.039), and the LDL/HDL ratio (LDL/HDL) (p=0.013) were independent predictors of coronary artery stenosis and the LDL/HDL (p=0.042) independently predicted vulnerable coronary plaque by logistic regression analyses. Areas under the curves in receiver operating characteristic curve analysis of the maximum-IMT, LDL/HDL, and these two parameters combined were 0.711 (95% CI 0.601-0.820), 0.618 (0.508-0.728), and 0.732 (0.632-0.831), respectively, for predicting coronary artery stenosis and 0.655 (0.537-0.773), 0.629 (0.504-0.754), and 0.710 (0.601- 0.818), respectively, for predicting vulnerable coronary plaque. Conclusions: Male sex, duration of diabetes, elevated SBP, and LDL/HDL were independent predictors of coronary artery stenosis. LDL/HDL was an independent predictor of vulnerable coronary plaque. Maximum-IMT predicted both coronary stenosis and vulnerable coronary plaque. Adding LDL/HDL improved the prediction of coronary artery stenosis and vulnerable coronary plaque.

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  • The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome: A Meta-Analysis. 査読 国際誌

    Kazuya Fujihara, Satoru Kodama, Chika Horikawa, Sakiko Yoshizawa, Ayumi Sugawara, Reiko Hirasawa, Hitoshi Shimano, Yoko Yachi, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

    Sleep disorders   2013   150371 - 150371   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims. High prevalence of sleep apnea syndrome (SAS) has been reported in patients with diabetes. However, whether diabetic neuropathy (DN) contributes to this high prevalence is controversial. Our aim of this study is to compare the prevalence of SAS between patients with and without DN. Methods. Systematic literature searches were conducted for cross-sectional studies that reported the number of patients with DN and SAS using MEDLINE (from 1966 to Nov 5, 2012) and EMBASE (from 1974 to Nov 5, 2012). Odds ratios (ORs) of SAS related to DN were pooled with the Mantel-Haenszel method. Results. Data were obtained from 5 eligible studies (including 6 data sets, 880 participants, and 429 cases). Overall, the pooled OR of SAS in patients with DN compared with that in non-DN patients was significant (OR (95% CI), -1.95 (1.03-3.70)). The pooled OR of SAS was 1.90 (0.97-3.71) in patients with type 2 diabetes. Excluding data on patients with type 1 diabetes, a higher OR was observed in younger patients (mean age <60 years) than in those ≥60 years among whom the OR remained significant (3.82; 95% CI, 2.24-6.51 and 1.17; 95% CI, 0.81-1.68). Conclusions. Current meta-analysis suggested the association of some elements of neuropathy with SAS in type 2 diabetes. Further investigations are needed to clarify whether the association is also true for patients with type 1 diabetes.

    DOI: 10.1155/2013/150371

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  • Comparisons of the Strength of Associations With Future Type 2 Diabetes Risk Among Anthropometric Obesity Indicators, Including Waist-to-Height Ratio: A Meta-Analysis 査読

    Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Yoriko Heianza, Reiko Hirasawa, Yoko Yachi, Ayumi Sugawara, Shiro Tanaka, Hitoshi Shimano, Kaoruko Tada Iida, Kazumi Saito, Hirohito Sone

    AMERICAN JOURNAL OF EPIDEMIOLOGY   176 ( 11 )   959 - 969   2012年12月

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    記述言語:英語   出版者・発行元:OXFORD UNIV PRESS INC  

    The aim of this meta-analysis was to compare the association of waist-to-height ratio (WHtR) with risk of incident diabetes with the associations of 3 other conventional obesity indicators (body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR)) with risk of incident diabetes. Literature searches in MEDLINE (January 1950 to April 27, 2011) and EMBASE (January 1974 to April 27, 2011) were conducted for prospective studies that made it possible to estimate the relative risk of diabetes per 1-standard deviation increase in WHtR, in addition to the RR of BMI, WC, or WHR. Strength of the estimated pooled relative risk for a 1-standard deviation increase of each indicator (expressed as RRWHtR, RRBMI, RRWC, and RRWHR) was compared with a bivariate random-effects model. Pooled relative risks of the 15 eligible studies with 6,472 diabetes cases were 1.62 (95 CI: 1.48, 1.78) for RRWHtR, 1.55 (95 CI: 1.43, 1.69) for RRBMI, 1.63 (95 CI: 1.49, 1.79) for RRWC, and 1.52 (95 CI: 1.40, 1.66) for RRWHR. WHtR had an association stronger than that of BMI (P0.001) or WHR (P0.001). The present meta-analysis showed that WHtR has a modestly but statistically greater importance than BMI and WHR in prediction of diabetes. Nevertheless, measuring height in addition to WC appeared to have no additional benefit.

    DOI: 10.1093/aje/kws172

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  • High normal HbA1c levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: The Toranomon Hospital Health Management Center Study 8 (TOPICS 8) 査読

    Y. Heianza, Y. Arase, K. Fujihara, H. Tsuji, K. Saito, S. D. Hsieh, S. Kodama, H. Shimano, N. Yamada, S. Hara, H. Sone

    Diabetic Medicine   29 ( 10 )   1285 - 1290   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims We aimed to characterize the association of insulin resistance, impaired insulin secretion and β-cell dysfunction in relation to HbA1c levels in a non-diabetic range in Japanese individuals without clinically diagnosed diabetes. Methods This cross-sectional study included 1444 individuals without a history of outpatient treatment of diabetes or use of insulin or oral hypoglycaemic agents. The homeostasis model assessment of insulin resistance and beta-cell function, insulinogenic index, Matsuda index and disposition index were calculated using data from 75-g oral glucose tolerance tests and compared across quintile (Q) categories of HbA1c levels. Results Fasting plasma glucose and 30-min and 60-min plasma glucose (PG) levels were significantly higher when HbA1c exceeded 36mmol/mol (5.4%). A HbA1c concentration of 36-37mmol/mol (5.4-5.5%) (Q3) was significantly associated with a 15% lower homeostasis model assessment of β-cell function value and 31% lower insulinogenic index value compared with HbA1c≤32mmol/mol (≤5.1%) (Q1) (P&lt
    0.01). Further, a HbA1c concentration of 38-40mmol/mol (5.6-5.8%) (Q4) was associated with 17% (P&lt
    0.01) and 24% (P&lt
    0.05) reductions in those indexes, respectively. However, the homeostasis model assessment of insulin resistance was not significantly elevated and the Matsuda index was not significantly lower unless HbA1c exceeded 41mmol/mol (5.9%). Individuals with HbA1c≥41mmol/mol (≥5.9%) (Q5) had a 69% lower disposition index than those with a HbA1c concentration of ≤32mmol/mol (≤5.1%) (Q1). Conclusions Elevated HbA1c levels ≥41mmol/mol (≥5.9%) were associated with substantial reductions in insulin secretion, insulin sensitivity and β-cell dysfunction in Japanese individuals not treated for diabetes. High normal HbA1c levels of 36-40mmol/mol (5.4-5.8%) were also associated with impaired insulin secretion without marked insulin resistance in Japanese individuals. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.

    DOI: 10.1111/j.1464-5491.2012.03667.x

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  • Screening for pre-diabetes to predict future diabetes using various cut-off points for HbA1c and impaired fasting glucose: the Toranomon Hospital Health Management Center Study 4 (TOPICS 4)

    Heianza, Y, Arase, Y, Fujihara, K, Tsuji, H, Saito, K, Hsieh, S. D, Kodama, S, Shimano, H, Yamada, N, Hara, S, Sone, H

    DIABETIC MEDICINE   29 ( 9 )   E279 - E285   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/j.1464-5491.2012.03686.x

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  • Longitudinal Trajectories of HbA(1c) and Fasting Plasma Glucose Levels During the Development of Type 2 Diabetes The Toranomon Hospital Health Management Center Study 7 (TOPICS 7) 査読

    Yoriko Heianza, Yasuji Arase, Kazuya Fujhara, Shiun Dung Hsieh, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Naoya Yahagi, Hitosh Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

    DIABETES CARE   35 ( 5 )   1050 - 1052   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER DIABETES ASSOC  

    OBJECTIVE-To describe the trajectory of HbA(1c), and glucose concentrations before the diagnosis of diabetes.
    RESEARCH DESIGN AND METHODS-The study comprised 1,722 nondiabetic Japanese individuals aged 26-80 years. Fasting plasma glucose (FPG) and HbA(1c) were measured annually for a mean of 9.5 (SD 1.8) years.
    RESULTS-Diabetes occurred in 193 individuals (FPG &gt;= 7.0 mmol/L, self-reported clinician-diagnosed diabetes, or HbA(1c) &gt;= 6.5%). Mean HbA(1c) values were &gt;5.6% each year before diagnosis in diabetes cases. Mean HbA(1c) (5.69% [95% CI 5.50-5.88]) was higher in the 21 individuals who developed diabetes 10 years after the baseline examination than in nondiabetic individuals after 10 years (5.27% [5.25-5.28]). From 3 years to 1 year prediagriosis, HbA(1c) increased 0.09% (SE 0.01)/year, reaching 5.90% (5.84-5.96) 1 year prediagnosis. In the entire group, marked increases in HbA(1c) of 0.3% (SE 0.05%)/year and FPG of 0.63 (0.07) mmol/L/year predicted diabetes.
    CONCLUSIONS HbA(1c) trajectory increased sharply after gradual long-term increases in diabetic individuals.

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  • [New vision of secondary and tertiary prevention in diabetic complication]. 査読

    Fujihara K, Sone H

    Nihon rinsho. Japanese journal of clinical medicine   70 Suppl 3   561 - 569   2012年5月

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  • Impact of psychological stress caused by the Great East Japan Earthquake on glycemic control in patients with diabetes 査読

    K. Fujihara, A. Saito, Y. Heianza, H. Gibo, H. Suzuki, H. Shimano, K. Saito, S. Kodama, N. Yamada, H. Sone

    Experimental and Clinical Endocrinology and Diabetes   120 ( 9 )   560 - 563   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We examined the relationship between psychological stress and the worsening of glycemic control in diabetic patients at the time of the Great East Japan Earthquake. HbA1c levels in diabetic patients before and after the disaster were evaluated with the General Health Questionnaire (GHQ) and other questions including those on changes in diet, exercise, psychological stress and drug intake in 320 consecutive diabetic patients who had been followed in a diabetes clinic. Logistic regression analysis revealed that the total GHQ scores (odds ratio [OR] 1.03 [95% confidence interval 1.01-1.06]
    p&lt
    0.01) and interruption of drug intake (OR 4.48 [1.57-12.7]
    p=0.01) were independently associated with worsening of glycemic control defined as an increase in the HbA1c level equal to or greater than 0.5%. Among the scores on the GHQ, those for somatic symptoms (OR 1.18 [1.01-1.38]
    p=0.03) and sleep disturbances or anxiety (OR 1.26 [1.08-1.46]
    p&lt
    0.01) were independently associated with glycemic control. These results suggest that psychological stress during a disaster has independent effects on worsening of glycemic control. © Georg Thieme Verlag KG Stuttgart · New York.

    DOI: 10.1055/s-0032-1314873

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  • Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS) 査読

    Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

    DIABETES   60   A235 - A235   2011年7月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

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  • Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS) 査読

    Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

    DIABETES   60   A235 - A235   2011年7月

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    記述言語:英語   出版者・発行元:AMER DIABETES ASSOC  

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  • 肥満が2型糖尿病,高血圧,脂質異常症の家族発症リスクに及ぼす影響

    池田和泉, 藤原和哉, 五十嵐理沙, 武田安永, 山田貴穂, 森保道, 門脇孝, 本田律子, 荒瀬康司, 曽根博仁

    日本内分泌学会雑誌   100 ( 1 )   2024年

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  • 本邦の小・中学生における睡眠習慣が肥満に及ぼす影響

    塩崎悠香, 藤原和哉, 武田安永, 池田和泉, 森川咲子, 森川咲子, 山田貴穂, 小川洋平, 曽根博仁

    日本内分泌学会雑誌   100 ( 1 )   2024年

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  • 中学2年時と20歳時との肥満を中心とした代謝指標の個別推移

    池田和泉, 藤原和哉, 武田安永, 塩崎悠香, 森川咲子, 森川咲子, 小川洋平, 石黒創, 山田貴穂, 曽根博仁

    日本内分泌学会雑誌   100 ( 1 )   2024年

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  • SGLT2阻害薬,メトホルミン内服中に重症低血糖とケトアシドーシス及び乳酸アシドーシスを併発した1例

    赤壁尚太, 土田大介, 滝澤大輝, 北澤勝, 松林泰弘, 山田貴穂, 藤原和哉, 富田大祐, 番場祐基, 西山慶, 曽根博仁

    日本内分泌学会雑誌   100 ( 1 )   2024年

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  • 写真撮影とAIを活用した食事記録スマートフォンアプリによる日常の食事記録の妥当性検証

    北澤勝, 堀川千嘉, 堀川千嘉, 長谷川美代, 武田安永, 治田麻理子, 松林泰弘, 山田貴穂, 児玉暁, 藤原和哉, 曽根博仁

    糖尿病(Web)   66 ( Suppl )   2023年

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  • 耐糖能や年齢で層別化した血清アミラーゼ低値およびその経時的減少が2型糖尿病発症に及ぼす影響の縦断的検討

    池田和泉, 藤原和哉, 大澤妙子, 武田安永, 治田麻里子, 松林泰弘, 児玉暁, 森保道, 本田律子, 門脇孝, 荒瀬康司, 曽根博仁

    糖尿病(Web)   66 ( Suppl )   2023年

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  • Combined Effects of Fruit and Vegetable Intake on Obesity in Japanese Patients with Type 2 Diabetes

    Mizuki Takeuchi, Mariko Hatta, Chika Horikawa, Yasunaga Takeda, Noriko Kato, Mitsutoshi Kato, Hiroki Yokoyama, Toshiko Saito, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

    DIABETES   71   2022年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db22-1516-PUB

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  • Secular Trends in Dietary Intake Over a Five-Year Period in People with Type 2 Diabetes in Japan: Japan Diabetes Complications Study (JDCS)

    Chika Horikawa, Rei Aida, Chiemi Kamada, Kazuya Fujihara, Shiro Tanaka, Atsushi Araki, Yukio Yoshimura, Yasuo Akanuma, Hirohito Sone

    DIABETES   71   2022年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db22-1179-P

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  • Association between Screen Time, Including That for Smartphones, and Overweight/Obesity among Children in Japan

    Izumi Ikeda, Kazuya Fujihara, Sakiko Y. Morikawa, Yasunaga Takeda, Hajime Ishiguro, Mayuko H. Yamada, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Yohei Ogawa, Hirohito Sone

    DIABETES   71   2022年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db22-1438-P

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  • Impact of Sodium Intake on the Risk of Cardiovascular Disease in Patients with Type 2 Diabetes: Analysis of Data from the Japan Diabetes Complications Study and the Japanese Elderly Diabetes Intervention Trial

    Chika Horikawa, Rei Aida, Shiro Tanaka, Chiemi Kamada, Yukio Yoshimura, Remi Kodera, Kazuya Fujihara, Tatsumi Moriya, Atsushi Araki, Hirohito Sone

    DIABETES   70   2021年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db21-371-P

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  • Sodium Intake and Incidence of Diabetes Retinopathy in Elderly Patients with Type 2 Diabetes: Analysis of Data from the Japanese Elderly Diabetes Intervention Study (J-EDIT)

    Chika Horikawa, Rei Aida, Shiro Tanaka, Chiemi Kamada, Sachiko Tanaka, Yukio Yoshimura, Remi Kodera, Kazuya Fujihara, Ryo Kawasaki, Tatsumi Moriya, Hirohito Sone, Atsushi Araki

    DIABETES   70   2021年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    0

    DOI: 10.2337/db21-432-P

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  • ニボルマブ投与後に同時期に破壊性甲状腺炎,1型糖尿病,下垂体機能低下症をきたした1例

    齋藤啓輔, 矢口雄大, 西井郁生, 山本正彦, 石黒創, 北澤勝, 松林泰弘, 鈴木浩史, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

    日本内分泌学会雑誌   97 ( 1 )   2021年

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  • 経口血糖降下薬(OHA)の服薬アドヒアランスに関連する因子および血糖コントロールとの関連

    矢口雄大, 藤原和哉, 山田万祐子, 北澤勝, 金子正儀, 清田浩康, 松林泰弘, 曽根博仁

    日本内分泌学会雑誌   97 ( 1 )   2021年

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  • Association of Higher Baseline BNP Levels with a Greater Reduction in Plasma Volume and Increase in Beta-Hydroxybutyrate via the SGLT2 Inhibitor Tofogliflozin in Type 2 Diabetes

    Akihiro Yoshida, Yasuhiro Matsubayashi, Toshiaki Nojima, Hideki Suganami, Momoko Oe, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

    DIABETES   69   2020年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db20-1133-P

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  • Dietary Patterns Significantly Associated with Obesity in Japanese with Type 2 Diabetes: JDDM

    Mariko Hatta, Kazuya Fujihara, Izumi Ikeda, Mizuki Takeuchi, Rina Nedachi, Sakiko Y. Morikawa, Chika Horikawa, Mitsutoshi Kato, Noriko Kato, Hiroshi Maegawa, Hirohito Sone

    DIABETES   69   2020年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db20-1541-P

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  • 著明な嚥下障害を呈したKearns-Sayre症候群に合併した糖尿病の1例

    種村聡, 山本正彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 渡邊賢一, 曽根博仁

    糖尿病(Web)   63 ( 8 )   2020年

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  • 粘液水腫性昏睡に急性膵炎を合併した一例

    齋藤啓輔, 滝澤祥子, 西井郁生, 竹内亮, 矢口雄大, 山本正彦, 川田亮, 石黒創, 北澤勝, 松林泰弘, 鈴木浩史, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

    日本内分泌学会雑誌   96 ( 2 )   2020年

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  • 汎血球減少を伴ったバセドウ病の一例

    日向裕大, 渡辺聖央, 佐藤隆明, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

    日本内分泌学会雑誌   96 ( 2 )   2020年

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  • 加齢に伴う握力の変化と追跡期間中の握力に影響する要因:新潟ウェルネススタディ

    門間陽樹, 門間陽樹, 加藤公則, 加藤公則, 澤田亨, 丸藤祐子, 川上諒子, 宮地元彦, 永富良一, 田代稔, 藤原和哉, 曽根博仁

    日本疫学会学術総会講演集(Web)   30th   2020年

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  • 1型糖尿病に対して膵腎同時移植を施行し透析およびインスリンを離脱した1例

    岸裕太郎, 竹内亮, 山本正彦, 松林泰弘, 藤原和哉, 岩永みどり, 山田高穂, 曽根博仁, 三浦宏平, 小林隆, 若井俊文

    糖尿病(Web)   63 ( 8 )   2020年

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  • バセドウ病合併妊婦において,分娩後に著しい甲状腺機能亢進症・無痛性甲状腺炎を呈した一例

    岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 曽根博仁

    日本内分泌学会雑誌   96 ( 3 (Web) )   2020年

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  • 2型糖尿病患者におけるカルシウム摂取量と腎症発症リスクとの関係:JDCS

    堀川千嘉, 相田麗, 田中司朗, 田中明, 井藤秀喜, 吉村幸雄, 大橋靖雄, 藤原和哉, 赤沼安夫, 曽根博仁

    日本疫学会学術総会講演集(Web)   30th   2020年

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  • わが国の最近の生活習慣病コホート/ビッグデータ研究と臨床試験 IV.ビッグデータ研究からAIの活用へ 1.巨大レセプトデータを活用した糖尿病診療

    藤原和哉

    Lipid   30 ( 3 )   302‐314   2019年7月

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    記述言語:日本語  

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  • Blake's pouch cystに伴う水頭症の治療により若年性認知症の改善を認めた糖尿病の1例

    種村 聡, 山本 正彦, 石黒 創, 岩永 みどり, 松林 泰弘, 山田 貴穂, 藤原 和哉, 渡邊 賢一, 曽根 博仁

    糖尿病   62 ( 7 )   441 - 441   2019年7月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Impact of Prior Coronary Artery Disease (CAD)/Cerebrovascular Disease (CVD) and Diabetes Mellitus (DM) on Incident CAD/CVD in Japanese

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    糖尿病   62 ( Suppl.1 )   S - 195   2019年4月

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    糖尿病   62 ( Suppl.1 )   S - 190   2019年4月

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  • 脂肪細胞インスリン抵抗性からみたSGLT2阻害薬投与によるケトン体上昇予測因子の検討

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    記述言語:日本語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:Japan Diabetes Society  

    We retrospectively analyzed the CoDiC data from 39 institutes in the JDDM in order to clarify the progression of kidney dysfunction over 5 years and factors related to this progression among type 2 diabetes patients progressing to stage 4 diabetic nephropathy. The present study clarified that 1) about 1.7 times more patients recovered from the stage 4 to the stage 3 than those who remained in stage 4, 2) the estimated glomerular filtration rate (eGFR) in 37.4 % of patients who remained in stage 4 progressively declined with a mean rate of -3.6 mL/min/year over 5 years, while that in the rest of patients was maintained at roughly the starting value (initially 25.8
    5 years later 24.4 mL/min/1.73 m2). On comparing the patient profiles between the decliners and the non-decliners, a younger age, a low eGFR just before the study, a high systolic blood pressure and a high non-HDL cholesterol level were significantly associated with a severe decline (P&lt
    0.01). However, a propensity score matching analysis further clarified that the influence of these four risk factors on a severe decline was slight. These findings suggested that direct causes provoked the stage 4 by acute kidney injury were important for the kidney function prognosis, in addition to the genetic and pathological background characteristics of each patient.

    DOI: 10.11213/tonyobyo.62.714

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  • バセドウ病治療に伴う無顆粒球症の治療中、血球貪食症候群を発症した一例

    三ツ間 友里恵, 橋本 浩平, 山本 正彦, 金子 正儀, 松林 泰弘, 山田 貴穂, 岩永 みどり, 藤原 和哉, 曽根 博仁, 福武 嶺一

    日本内分泌学会雑誌   94 ( 3 )   846 - 846   2018年12月

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  • 入院下と外来でCGMを装着し血糖変化を確認した1型糖尿病の一例

    橋本 浩平, 金子 正儀, 三ツ間 友里恵, 山本 正彦, 松林 泰弘, 岩永 みどり, 松永 佐澄志, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本先進糖尿病治療研究会雑誌   14   39 - 39   2018年11月

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    記述言語:日本語   出版者・発行元:日本先進糖尿病治療研究会  

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  • 胃亜全摘術後の2型糖尿病患者における治療強化の手段として,DPP‐4阻害薬からGLP‐1受容体作動薬への変更は有効か

    白石友信, 吉岡大志, 松林泰弘, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

    日本先進糖尿病治療研究会雑誌   14   44   2018年11月

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  • 糖尿病患者の下肢切断の頻度とリスク因子の検討

    金子正儀, 藤原和哉, 原田万祐子, 松林泰弘, 北澤勝, 石井大, 清田浩康, 山中菜詩, 児玉暁, 曽根博仁

    糖尿病合併症   32 ( Supplement 1 )   291   2018年10月

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  • 糖尿病患者における心不全発症リスクの系統レビュー・メタ解析

    児玉暁, 藤原和哉, 岩永みどり, 鈴木浩史, 山田貴穂, 渡辺賢一, 加藤公則, 曽根博仁

    糖尿病合併症   32 ( Supplement 1 )   287   2018年10月

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  • 腎臓病 脈圧が透析導入に及ぼす影響の検討

    大澤 妙子, 藤原 和哉, 山本 正彦, 原田 万由子, 石澤 正博, 清田 浩康, 山中 菜詩, 松林 泰弘, 松永 佐澄志, 山田 貴穂, 曽根 博仁

    糖尿病合併症   32 ( Suppl.1 )   245 - 245   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 胃亜全摘後の糖尿病患者において、DPP-4阻害薬からGLP-1受容体作動薬への変更は有効か

    白石 友信, 吉岡 大志, 松林 泰弘, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    糖尿病   61 ( 10 )   721 - 721   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 1型糖尿病の発症以前にバセドウ病が先行したと考えられる14歳女児の1例

    橋本 浩平, 金子 正儀, 三ツ間 友里恵, 山本 正彦, 松林 泰弘, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    糖尿病   61 ( 10 )   700 - 700   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 高齢発症の劇症1型糖尿病の1例

    吉岡 大志, 小松 健, 皆川 真一, 松林 泰弘, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 今川 彰久, 曽根 博仁

    糖尿病   61 ( 10 )   726 - 726   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 糖尿病腎症が重症糖尿病性眼疾患の発生に及ぼす影響

    山本 正彦, 藤原 和哉, 石澤 正博, 大澤 妙子, 石黒 創, 岩永 みどり, 松林 泰弘, 清田 浩康, 山中 菜詩, 山田 貴穂, 長谷部 日, 曽根 博仁

    糖尿病合併症   32 ( Suppl.1 )   299 - 299   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 心血管 耐糖能別にみた肥満及び代謝異常が冠動脈疾患発症へ及ぼす影響の検討

    藤原 和哉, 松林 泰弘, 原田 万祐子, 山本 正彦, 大澤 妙子, 金子 正儀, 松永 佐澄志, 山田 貴穂, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁

    糖尿病合併症   32 ( Suppl.1 )   206 - 206   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 当科で経験した下垂体茎断裂症候群の1例

    佐藤隆明, 福武嶺一, 金子正儀, 岩永みどり, 松林泰弘, 山田貴徳, 藤原和哉, 曽根博仁

    日本内分泌学会雑誌   94 ( 2 )   680   2018年9月

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  • ACTH依存性に増大を認めた,クッシング症候群を伴う副腎癌の1例

    北澤勝, 北澤勝, 張かおり, 矢口雄大, 鈴木達郎, 金子正儀, 松林泰弘, 藤原和哉, 八幡和明, 曽根博仁

    日本内分泌学会雑誌   94 ( 2 )   716   2018年9月

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  • 肥満境界型糖尿病患者に対する血糖自己測定と「血糖に変わる速度と割合」の理解度との関係

    長谷川美代, 堀川千嘉, 藤原和哉, 曽根博仁

    栄養学雑誌   76 ( 5 Supplement )   189   2018年9月

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  • 青少年の心肺持久力及び筋力と代謝異常リスクの関連

    森川 咲子, 石黒 創, 堀川 千嘉, 石井 大, 武田 安永, 治田 麻里子, 松林 泰弘, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本臨床運動療法学会学術集会プログラム・抄録集   37回 ( 1 )   43 - 43   2018年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本臨床運動療法学会  

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  • メタ解析を用いた、2型糖尿病患者におけるレジスタンストレーニングの有用性の検討

    石黒 創, 児玉 暁, 森川 咲子, 堀川 千嘉, 石井 大, 治田 麻理子, 張 かおり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本臨床運動療法学会学術集会プログラム・抄録集   37回 ( 1 )   53 - 53   2018年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本臨床運動療法学会  

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  • 高齢者の生活習慣病 高齢者の生活習慣修正 高齢者の身体活動と生活習慣病

    北澤勝, 藤原和哉, 曽根博仁

    日本臨床   76   139‐143   2018年8月

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  • 当科で経験した小児クッシング症候群の1例

    三ツ間 友里恵, 金子 正儀, 山本 正彦, 橋本 浩平, 矢口 雄大, 鈴木 達郎, 石黒 創, 松林 泰弘, 山田 貴穂, 岩永 みどり, 藤原 和哉, 曽根 博仁, 長崎 啓祐, 齋藤 和英, 羽入 修

    新潟医学会雑誌   132 ( 7 )   287 - 287   2018年7月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • Effect of Number of Achieved Targets for Risk Factors on Coronary Artery Disease (CAD) in Those With and Without Diabetes Mellitus (DM)

    Kazuya Fujihara, Yasuhiro Matsubayashi, Masaru Kitazawa, Masahiko Yamamoto, Taeko Osawa, Masanori Kaneko, Nauta Yamanaka, Hiroyasu Seida, Kiminori Kato, Satoru Kodama, Hirohito Sone

    DIABETES   67   2018年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-442-P

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  • Test Strip-Positive Proteinuria and Its Combination with Low eGFR Are Predictive of Treatment-Required Eye Diseases in Japanese Patients with Diabetes Mellitus

    Masahiko Yamamoto, Kazuya Fujihara, Taeko Osawa, Mayuko Harada, Masahiro Ishizawa, Hajime Ishiguro, Hiroshi Suzuki, Hiroyasu Seida, Nauta Yamanaka, Yasuhiro Matsubayashi, Hirohito Sone

    DIABETES   67   2018年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-594-P

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  • Incidence and Risk Factors for Amputation in Patients with Diabetes in Japan-Historical Cohort Study Using a Nationwide Claims Database

    Masanori Kaneko, Kazuya Fujihara, Masahiko Yamamoto, Masaru Kitazawa, Masahiro Ishizawa, Taeko Osawa, Mayuko Harada, Yasuhiro Matsubayashi, Takaho Yamada, Hirohito Sone

    DIABETES   67   2018年7月

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    DOI: 10.2337/db18-637-P

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  • Effects of Treatment-Achieved HbA1c on Incidence of Micro-/Macrovascular Complications in Patients with Diabetes Mellitus

    Mayuko Harada, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Yasuhiro Matsubayashi, Satoshi Matsunaga, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

    DIABETES   67   2018年7月

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    DOI: 10.2337/db18-444-P

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  • Dipstick Proteinuria as a Predictor of End-Stage Renal Disease in Japanese Adults With and Without Diabetes Mellitus (DM)

    Atsushi Furuya, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Mayuko Harada, Masahiro Ishizawa, Hiroyasu Seida, Nauta Yamanaka, Yasuhiro Matsubayashi, Hirohito Sone

    DIABETES   67   2018年7月

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    DOI: 10.2337/db18-2384-PUB

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  • Education for Family Members Is Effective for Improved Glycemic Control of Patients with Type 2 Rather than Type 1 Diabetes Mellitus-A Meta-analysis

    Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Yoko Yachi, Masahiro Ishizawa, Satoshi Matsunaga, Shiro Tanaka, Kiminori Kato, Hirohito Sone

    DIABETES   67   2018年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-823-P

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  • 耐糖能及び肥満の有無別にみた代謝異常が冠動脈疾患発症に及ぼす影響の検討

    藤原 和哉, 松林 泰弘, 山本 正彦, 金子 正儀, 松永 佐澄志, 山田 貴穂, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁

    日本動脈硬化学会総会プログラム・抄録集   50回   336 - 336   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 医療ビックデータを活用した新潟発の臨床疫学研究

    藤原和哉, 曽根博仁

    新潟医学会雑誌   132 ( 4 )   123‐126   2018年4月

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  • 肥満と肝インスリンクリアランス(Hepatic insulin clearance:HIC)低下の関係における脂肪肝(Fatty Liver:FL)の役割

    松林泰弘, 吉田明弘, 吉田明弘, 菅波秀規, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 加来浩平, 曽根博仁

    日本内分泌学会雑誌   94 ( 1 )   432   2018年4月

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  • アミオダロン誘発甲状腺中毒症を呈した2例

    村松愛子, 村松愛子, 深澤洋, 藤原和哉, 藤原和哉, 藤井優尚, 熊谷亮, 片倉幸乃, 森川亮, 野牛宏晃

    日本内分泌学会雑誌   94 ( 1 )   374   2018年4月

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  • 原発性アルドステロン症と原発性副甲状腺機能亢進症を併発した1例

    白石友信, 吉岡大志, 松林泰弘, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

    日本内分泌学会雑誌   94 ( 1 )   430   2018年4月

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  • 肥満境界型糖尿病患者に対する血糖自己測定と栄養指導媒体を用いた栄養教育の併用効果について

    長谷川 美代, 堀川 千嘉, 田代 稔, 鈴木 沙織, 藤原 和哉, 北澤 勝, 加藤 公則, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 267   2018年4月

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  • 2型糖尿病患者における食事エネルギー密度と肥満との関連 JDDMにおける検討

    武田 安永, 藤原 和哉, 治田 麻理子, 森川 咲子, 堀川 千嘉, 石井 大, 加藤 光敏, 横山 宏樹, 栗原 義夫, 宮澤 一裕, 岩崎 晧一, 川井 紘一, 朝長 修, 屋宜 宣治, 前川 聡, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 265   2018年4月

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  • 耐糖能及び肥満の有無に関わらず代謝異常は冠動脈疾患発症リスクを増大させる

    藤原 和哉, 松林 泰弘, 山本 正彦, 松永 佐澄志, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 260   2018年4月

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  • 年齢層別に見た血清アミラーゼ値と2型糖尿病発症との関連

    石井 大, 藤原 和哉, 治田 麻理子, 原田 万佑子, 松林 泰弘, 斎藤 和美, 児玉 暁, 森 保道, 本田 律子, 荒瀬 康司, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 161   2018年4月

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  • 眼科処置を要する重症糖尿病性眼疾患の発生リスクに対する腎症の影響についての検討

    山本 正彦, 藤原 和哉, 大澤 妙子, 原田 万祐子, 石黒 創, 石澤 正博, 岩永 みどり, 松永 佐澄志, 松林 泰弘, 清田 浩康, 山中 菜詩, 山田 貴穂, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 161   2018年4月

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  • 糖尿病患者における脈圧が透析導入に及ぼす影響の検討

    大澤 妙子, 藤原 和哉, 山本 正彦, 原田 万由子, 石澤 正博, 清田 浩康, 山中 菜詩, 松林 泰弘, 松永 佐澄志, 山田 貴穂, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 160   2018年4月

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  • SGLT2阻害薬が安静時心拍数(Resting Heart Rate:RHR)に及ぼす影響とその関連因子の検討

    松林 泰弘, 阿部 孝洋, 吉田 明弘, 野島 俊秋, 菅波 秀規, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 加来 浩平, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 158   2018年4月

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  • 糖尿病治療薬別にみたHbA1cと冠動脈疾患(CAD)発症リスクとの関連

    原田 万祐子, 藤原 和哉, 大澤 妙子, 石澤 正博, 山本 正彦, 金子 正儀, 松林 泰弘, 松永 佐澄志, 山中 菜詩, 清田 浩康, 山田 貴穂, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 258   2018年4月

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  • DPP-4阻害薬アナグリプチン(ANA)の12週間投与時におけるインスリンクリアランスに及ぼす影響

    阿部 孝洋, 松林 泰弘, 村岸 沙也加, 吉田 明弘, 菅波 秀規, 古澤 研一, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 加来 浩平, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 246   2018年4月

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  • 当院における糖尿病合併妊娠及び妊娠糖尿病患者への分割食の栄養指導の実態と指導方法の検討

    治田 麻理子, 深沢 尚子, 桜井 健一, 津野 菜津美, 佐藤 かえで, 西山 陽子, 藤原 和哉, 曽根 博仁, 鈴木 克典

    糖尿病   61 ( Suppl.1 )   S - 214   2018年4月

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  • 診断に難渋した再発性重症低血糖の原因特定に薬物血中濃度測定が有用であった一例

    三ツ間 友里恵, 山本 正彦, 橋本 浩平, 金子 正儀, 松林 泰弘, 松永 佐澄志, 山田 貴穂, 岩永 みどり, 藤原 和哉, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 181   2018年4月

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  • 糖尿病患者の受診中断に関連する因子の1年間追跡調査 糖尿病データマネジメント研究会(JDDM)より

    谷内田 潤子, 藤原 和哉, 武田 安永, 治田 麻里子, 石井 大, 和井田 結佳子, 大石 まり子, 川井 紘一, 横山 宏樹, 前川 聡, 曽根 博仁, 糖尿病データマネジメント研究会

    糖尿病   61 ( Suppl.1 )   S - 139   2018年4月

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  • 指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み

    山田 貴穂, 石井 大, 武田 安永, 橋本 浩平, 三ツ間 友里恵, 張 かおり, 原田 万祐子, 白石 友信, 吉岡 大志, 山本 正彦, 大澤 妙子, 石黒 創, 金子 正儀, 鈴木 浩史, 松林 泰弘, 松永 佐澄志, 藤原 和哉, 岩永 みどり, 鈴木 亜希子, 羽入 修, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 377   2018年4月

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  • 菌状息肉症に対するベキサロテン治療後に出現した副作用例の検討

    山本 正彦, 棚橋 怜生, 松林 泰弘, 藤原 和哉, 北澤 勝, 松永 佐澄志, 金子 正儀, 鈴木 浩史, 石澤 正博, 岩永 みどり, 山田 貴穂, 曽根 博仁

    日本内分泌学会雑誌   94 ( 1 )   420 - 420   2018年4月

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  • ポリファーマシーの問題点と解決策 糖尿病患者における薬物処方の現状と多剤処方

    藤原和哉, 曽根博仁

    カレントテラピー   36 ( 2 )   163‐168   2018年2月

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    記述言語:日本語  

    DOI: 10.15022/00004446

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  • 勤労世代男性における各耐糖能が冠動脈疾患発症に及ぼす影響の検討

    藤原和哉, 松林泰弘, 石澤正博, 山本正彦, 松永佐澄志, 山田貴穂, 山中菜詩, 清田浩康, 児玉暁, 曽根博仁

    日本疫学会学術総会講演集(Web)   28th   76 (WEB ONLY)   2018年2月

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  • エビデンスを2型糖尿病臨床にどう生かせばいい?―Evidence Based MedicineをReal Worldへ 大規模臨床試験の結果を糖尿病臨床に生かす際の注意点

    北澤勝, 藤原和哉, 曽根博仁

    内科   121 ( 1 )   11‐15   2018年1月

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    記述言語:日本語  

    DOI: 10.15106/j_naika121_11

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  • 原発巣の同定に至らなかった癌の1例

    橋本 浩平, 三ツ間 友里恵, 山本 正彦, 金子 正儀, 松林 泰弘, 山田 貴穂, 岩永 みどり, 松永 佐澄志, 藤原 和哉, 曽根 博仁

    新潟医学会雑誌   132 ( 1 )   31 - 31   2018年1月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 1型糖尿病の発症以前にバセドウ病が先行したと考えられる14歳女児の1例

    橋本浩平, 金子正儀, 三ツ間友里恵, 山本正彦, 松林泰弘, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

    糖尿病(Web)   61 ( 10 )   700(J‐STAGE)   2018年

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  • ZnT8抗体が単独陽性であった急性発症1型糖尿病の1例

    戒能賢太, 五十嵐桃子, 五十嵐桃子, 大庭詩恵, 熊谷亮, 村松愛子, 藤原和哉, 野牛宏晃

    糖尿病(Web)   61 ( 8 )   554(J‐STAGE)   2018年

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  • シタグリプチンによる水疱性類天疱瘡が疑われた1例

    藤井優尚, 熊谷亮, 藤原和哉, 村松愛子, 五十野桃子, 入山大希, 戒能賢太, 田口詩路麻, 野牛宏晃

    糖尿病(Web)   61 ( 8 )   557(J‐STAGE)   2018年

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  • 当院での糖尿病患者の服薬状況に関する調査結果

    永井満, 古川和朗, 細川浩輝, 石井貴之, 市川セツ子, 遠藤明日香, 高橋一美, 松永佐澄志, 藤原和哉

    糖尿病(Web)   61 ( 10 )   716(J‐STAGE)   2018年

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  • 胃亜全摘後の糖尿病患者において,DPP‐4阻害薬からGLP‐1受容体作動薬への変更は有効か

    白石友信, 吉岡大志, 松林泰弘, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

    糖尿病(Web)   61 ( 10 )   721(J‐STAGE)   2018年

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  • 下肢皮膚潰瘍から骨髄炎に至った2型糖尿病の1例

    張かおり, 金子正儀, 佐藤陽子, 松林泰弘, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 羽入修, 曽根博仁

    糖尿病(Web)   61 ( 9 )   646(J‐STAGE)   2018年

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  • 高齢発症の劇症1型糖尿病の1例

    吉岡大志, 小松健, 皆川真一, 松林泰弘, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 今川彰久, 曽根博仁

    糖尿病(Web)   61 ( 10 )   726(J‐STAGE)   2018年

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  • SGLT2阻害薬内服後,腎盂腎炎敗血症性ショックを来したCushing症候群合併糖尿病の1例

    熊谷亮, 熊谷亮, 戒能賢太, 藤井優尚, 藤井優尚, 古川祥子, 村松愛子, 五十野桃子, 五十野桃子, 田一秀, 田一秀, 清水祐一, 藤原和哉, 野牛宏晃

    糖尿病(Web)   61 ( 8 )   561(J‐STAGE)   2018年

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  • ステロイド糖尿病を合併し歯性感染から上顎の骨髄炎を発症した2型糖尿病の1例

    棚橋怜生, 山本正彦, 松林泰弘, 松永佐澄志, 山田貴穂, 岩永みどり, 藤原和哉, 羽入修, 曽根博仁

    糖尿病(Web)   61 ( 9 )   644(J‐STAGE)   2018年

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  • 指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み

    山田貴穂, 山田貴穂, 石井大, 武田安永, 橋本浩平, 三ツ間友里恵, 張かおり, 原田万祐子, 白石友信, 吉岡大志, 山本正彦, 大澤妙子, 石黒創, 金子正儀, 鈴木浩史, 松林泰弘, 松林泰弘, 松永佐澄志, 藤原和哉, 岩永みどり, 鈴木亜希子, 鈴木亜希子, 羽入修, 羽入修, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 肥満境界型糖尿病患者に対する血糖自己測定と栄養指導媒体を用いた栄養教育の併用効果について

    長谷川美代, 堀川千嘉, 田代稔, 鈴木沙織, 藤原和哉, 北澤勝, 加藤公則, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 眼科処置を要する重症糖尿病性眼疾患の発生リスクに対する腎症の影響についての検討

    山本正彦, 藤原和哉, 大澤妙子, 原田万祐子, 石黒創, 石澤正博, 岩永みどり, 松永佐澄志, 松林泰弘, 清田浩康, 山中菜詩, 山田貴穂, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 2型糖尿病患者における食事エネルギー密度と肥満との関連-JDDMにおける検討-

    武田安永, 藤原和哉, 治田麻理子, 森川咲子, 森川咲子, 堀川千尋, 堀川千尋, 石井大, 加藤光敏, 横山宏樹, 栗原義夫, 宮澤一裕, 岩崎皓一, 川井紘一, 朝長修, 屋宜宣治, 前川聡, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 糖尿病患者の受診中断に関連する因子の1年間追跡調査~糖尿病データマネジメント研究会(JDDM)より~

    谷内田潤子, 谷内田潤子, 藤原和哉, 武田安永, 治田麻里子, 石井大, 和井田結佳子, 大石まり子, 川井紘一, 横山宏樹, 前川聡, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 年齢層別に見た血清アミラーゼ値と2型糖尿病発症との関連

    石井大, 藤原和哉, 藤原和哉, 治田麻理子, 原田万佑子, 松林泰弘, 斎藤和美, 児玉暁, 児玉暁, 森保道, 本田律子, 荒瀬康司, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • DPP-4阻害薬アナグリプチン(ANA)の12週間投与時におけるインスリンクリアランスに及ぼす影響

    阿部孝洋, 松林泰弘, 村岸沙也加, 吉田明弘, 吉田明弘, 菅波秀規, 古澤研一, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 加来浩平, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 診断に難渋した再発性重症低血糖の原因特定に薬物血中濃度測定が有用であった一例

    三ツ間友里恵, 山本正彦, 橋本浩平, 金子正儀, 松林泰弘, 松永佐澄志, 山田貴穂, 岩永みどり, 藤原和哉, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • SGLT2阻害薬が安静時心拍数(Resting Heart Rate:RHR)に及ぼす影響とその関連因子の検討

    松林泰弘, 阿部孝洋, 吉田明弘, 吉田明弘, 野島俊秋, 野島俊秋, 菅波秀規, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 加来浩平, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 耐糖能及び肥満の有無に関わらず代謝異常は冠動脈疾患発症リスクを増大させる

    藤原和哉, 松林泰弘, 山本正彦, 松永佐澄志, 清田浩康, 山中菜詩, 児玉暁, 曽根博仁

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 当院における糖尿病合併妊娠及び妊娠糖尿病患者への分割食の栄養指導の実態と指導方法の検討

    治田麻理子, 治田麻理子, 深沢向子, 桜井健一, 津野菜津美, 佐藤かえで, 西山陽子, 藤原和哉, 曽根博仁, 鈴木克典

    糖尿病(Web)   61 ( Suppl )   2018年

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  • FHHとPHPTの鑑別に苦慮している一例

    棚橋 怜生, 山本 正彦, 松林 泰弘, 張 かおり, 佐藤 陽子, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 曽根 博仁

    日本内分泌学会雑誌   93 ( 3 )   753 - 753   2017年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 6 重症低血糖を契機に発見されたIGF-2産生腫瘍によるNICTHの1例 (Ⅰ.一般演題, 第105回新潟内分泌代謝同好会)

    張 かおり, 金子 正儀, 佐藤 陽子, 松林 泰弘, 松永 佐澄志, 岩永 みどり, 山田 貴穂, 藤原 和哉, 羽入 修, 曽根 博仁, 福田 いずみ, 長嶋 洋治

    新潟医学会雑誌   131 ( 11 )   667 - 667   2017年11月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • 心血管疾患 糖尿病が冠動脈疾患発症へ与える影響は若年者と中年では大きく異なる

    藤原 和哉, 松林 泰弘, 山本 正彦, 石澤 正博, 松永 佐澄志, 山田 貴穂, 清田 浩康, 山中 菜詩, 児玉 暁, 曽根 博仁

    糖尿病合併症   31 ( Suppl.1 )   202 - 202   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病合併症学会  

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  • 膵島細胞症とインスリノーマの合併が疑われ診断に難渋した一例

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  • 原発巣の同定に至らなかった癌の一例

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  • 妊娠初期HbA1c値および空腹時血糖値と妊娠糖尿病発症予測能の検討<TWC Study>

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    New Diet Therapy   33 ( 2 )   194 - 194   2017年9月

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  • 骨粗鬆症検診と体力測定の関係についての横断的解析

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    人間ドック   32 ( 2 )   307 - 307   2017年8月

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  • 骨粗鬆症検診と体力測定の関係についての縦断的解析

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    人間ドック   32 ( 2 )   308 - 308   2017年8月

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  • 【糖尿病の日本人特異性〜日本的糖尿病学の確立へ〜】 日本人糖尿病合併症の特徴

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    月刊糖尿病   9 ( 6 )   93 - 102   2017年6月

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  • Effects on Fasting Free Fatty Acid (F-FFA) and Adipose-Tissue Insulin Resistance (Adipo-IR) after Long-Term Treatment of Type 2 Diabetes Mellitus (T2DM) with the SGLT2 inhibitor (SGLT2i) Tofogliflozin (TOFO)

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  • Impact of Individual Components and Their Combinations within a Family History (FH) of Diabetes on the Development of Diabetes

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    DIABETES   66   A418 - A418   2017年6月

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  • Trends In Dietary Intake by Patients with Type 2 Diabetes (T2DM) in Japan, 1996-2016

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  • Pulse Pressure and HbA1c Levels Are Significant Predictors of Vision-Threatening Eye Diseases in Japanese Patients with Diabetes Mellitus

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  • 耐糖能と肺機能の関連

    藤原和哉

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  • 重症低血糖を契機に発見されたIGF-II産生腫瘍の1例

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    新潟医学会雑誌   131 ( 5 )   320 - 320   2017年5月

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  • 重症低血糖を契機に発晃されたIGF‐2産生腫瘍によるNICTHの一例

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  • 骨密度に影響する身体測定値:人間ドックのデータ解析から

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    日本内分泌学会雑誌   93 ( 1 )   332   2017年4月

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  • 耐糖能別にみた収縮期血圧が透析導入に及ぼす影響の検討

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  • 糖尿病の詳細な家族歴が2型糖尿病発症リスクに与える影響の定量的検討

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  • トホグリフロジン(TOFO)長期投与が遊離脂肪酸及び脂肪細胞インスリン抵抗性に与える影響の検討

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  • 小児期の運動能力と心血管リスクに関する検討

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  • 勤労世代男性における耐糖能の冠動脈疾患発症への影響の検討

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    日本内分泌学会雑誌   93 ( 1 )   260 - 260   2017年4月

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  • 重症低血糖を契機に発見されたIGF-2産生腫瘍によるNICTHの一例

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  • 256‐QAMを適用したスモールセルのスループット特性

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  • マクロ/マイクロセルを基準とするスモールセル設計と256‐QAMの適用に関する検討

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  • 糖尿病患者の家族に対する教育が患者血糖に及ぼす効果のメタ分析

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  • 日本人男女における2型糖尿病発症予測のためのBMIおよびウエスト周囲径(WC)閾値の検討:NIWELLS

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  • 働き盛り世代男性における耐糖能の冠動脈疾患発症への影響の検討

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  • FHHとPHPTの鑑別に苦慮している一例

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  • 耐糖能別にみた収縮期血圧が透析導入に及ぼす影響の検討

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  • 糖尿病専門医の治療を受ける2型糖尿病患者の食事摂取状態の実態と時代的変遷~JDDMによる報告~(第二報)

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  • 骨粗鬆症検診と体力測定の関係―人間ドック受診者では糖代謝異常と骨密度と関連しない―

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