Faculty Profiles - ABE Tatsuya

写真a

ABE Tatsuya

Organization

Academic Assembly Institute of Medicine and Dentistry - Assistant Professor
Faculty of Dentistry Department of Dentistry Assistant Professor
Graduate School of Medicine, Dentistry and Health Sciences Medicine and Dentistry Assistant Professor

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Degree

博士（歯学） ( 2016.3 新潟大学 )

Research Interests

Pathohistology
Head and Neck Squamous Cell Carcinoma

Research Areas

Life Science / Human pathology / oral pathology

Research History (researchmap)

University Hospital of Basel Institute of Medical Genetics and Pathology Visiting Researcher

2025.7

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Country：Switzerland

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University of Basel Computational & Translational Pathology, Department of Biomedical Engineering Visiting Researcher

2025.6 - 2025.11

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Country：Switzerland

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University Hospital Zurich Molecular Pathology Visiting Scholar

2024.3

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Country：Switzerland

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Niigata University Assistant Professor

2020.4

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Niigata University Faculty of Medicine Specially Appointed Assistant Professor

2017.7 - 2020.3

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Niigata University Medical and Dental Hospital

2012.4 - 2017.6

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Research History

Niigata University Institute of Medicine and Dentistry, Academic Assembly Assistant Professor

2026.5
Niigata University Tissue Regeneration and Reconstruction, Oral Life Science, Graduate School of Medical and Dental Sciences Assistant Professor

2026.5
Niigata University Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction Assistant Professor

2020.4
Niigata University Graduate School of Medical and Dental Sciences Specially Appointed Assistant Professor

2017.7 - 2020.3

Qualification acquired

Dentist
日本病理学会認定　口腔病理専門医
死体解剖資格
日本臨床細胞学会認定　口腔細胞診専門歯科医
日本バイオインフォマティクス学会認定技術者

Papers

Early-Stage Oral Squamous Cell Carcinoma in Adolescents and Young Adults Compared with Older Patients Exhibits Distinct Clinicopathological Features Reviewed

Sawako Ono, Katsutoshi Hirose, Hotaka Kawai, Tatsuya Abe, Shintaro Sukegawa, Masanori Masui, Chihoko Ikeda, Madoka Isomura, Yuri Tachibana, Junya Ono, Katsumitsu Shimada, Hitoshi Nagatsuka, Hidetaka Yamamoto

Head and Neck Pathology 20 ( 1 ) 2026.7

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Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1007/s12105-026-01944-w

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Other Link： https://link.springer.com/article/10.1007/s12105-026-01944-w
Pathological diagnosis of oral mucosal lesions : current trends, challenges, and differential diagnosis in routine diagnostics Invited Reviewed

Tatsuya Abé, Satoshi Maruyama, Manabu Yamazaki, Jun-ichi Tanuma

Japanese Journal of Diagnostic Pathology 42 ( 4 ) 263 - 271 2025.11

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Authorship：Lead author,　Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.69281/jspjjdp.2025_07_0022

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Pre-epiglottic adenocarcinoma NOS presenting as a cystic mass: a diagnostic challenge and surgical management

Yuki Yamagata, Takeshi Takahashi, Shusuke Ohshima, Jo Omata, Yusuke Yokoyama, Ryusuke Shodo, Yushi Ueki, Tatsuya Abé, Hajime Umezu, Arata Horii

Oral Oncology 167 107451 - 107451 2025.8

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Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.oraloncology.2025.107451

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Progression of dysplasia in sessile serrated lesions with proliferative zone redistribution: ‘Top-down growth’ as a marker of malignant potential Reviewed

Kaori Takamura, Yoichi Ajioka, Tatsuya Abé, Tatiana Gritcun, Saori Takashima, Shuhei Kondo, Yusuke Tani, Riuko Ohashi

Virchows Archiv 2025.6

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Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1007/s00428-025-04144-z

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Other Link： https://link.springer.com/article/10.1007/s00428-025-04144-z/fulltext.html
Japanese clinical practice guidelines for oral cancer, 2023 Reviewed

H. Kurita, N. Uzawa, H. Nakayama, T. Abe, S. Ibaraki, Y. Ohyama, K. Uchida, H. Sato, S. Miyabe, T. Abé, N. Kakimoto, A. Kaida, T. Sugiura, M. Kioi, A. Danjo, N. Kitamura, O. Hasegawa, T. Tanaka, N. Ueda, T. Hasegawa, S. Asoda, H. Katsuta, S. Yanamoto, S. Yamada, D. Takeda, T. Suzuki, Y. Ohta, T. Kirita

International Journal of Oral and Maxillofacial Surgery 2024.12

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Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.ijom.2024.11.012

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Development and Characterization of a Three-Dimensional Organotypic In Vitro Oral Cancer Model with Four Co-Cultured Cell Types, Including Patient-Derived Cancer-Associated Fibroblasts Reviewed

Yuka Aizawa, Kenta Haga, Nagako Yoshiba, Witsanu Yortchan, Sho Takada, Rintaro Tanaka, Eriko Naito, Tatsuya Abé, Satoshi Maruyama, Manabu Yamazaki, Jun-ichi Tanuma, Kazuyo Igawa, Kei Tomihara, Shinsaku Togo, Kenji Izumi

Biomedicines 12 ( 10 ) 2373 - 2373 2024.10

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Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Background/Objectives: Cancer organoids have emerged as a valuable tool of three-dimensional (3D) cell cultures to investigate tumor heterogeneity and predict tumor behavior and treatment response. We developed a 3D organotypic culture model of oral squamous cell carcinoma (OSCC) to recapitulate the tumor–stromal interface by co-culturing four cell types, including patient-derived cancer-associated fibroblasts (PD-CAFs). Methods: A stainless-steel ring was used twice to create the horizontal positioning of the cancer stroma (adjoining normal oral mucosa connective tissue) and the OSCC layer (surrounding normal oral mucosa epithelial layer). Combined with a structured bi-layered model of the epithelial component and the underlying stroma, this protocol enabled us to construct four distinct portions mimicking the oral cancer tissue arising in the oral mucosa. Results: In this model, α-smooth muscle actin-positive PD-CAFs were localized in close proximity to the OSCC layer, suggesting a crosstalk between them. Furthermore, a linear laminin-γ2 expression was lacking at the interface between the OSCC layer and the underlying stromal layer, indicating the loss of the basement membrane-like structure. Conclusions: Since the specific 3D architecture and polarity mimicking oral cancer in vivo provides a more accurate milieu of the tumor microenvironment (TME), it could be crucial in elucidating oral cancer TME.

DOI： 10.3390/biomedicines12102373

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Ladinin-1 in actin arcs of oral squamous cell carcinoma is involved in cell migration and epithelial phenotype Reviewed

Tatsuya Abé, Manabu Yamazaki, Motohiro Nozumi, Satoshi Maruyama, Kaori Takamura, Riuko Ohashi, Yoichi Ajioka, Jun-ichi Tanuma

Scientific Reports 14 22778 2024.10

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Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-024-74041-z

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Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNBhigh cancer cells accelerates peritoneal dissemination Reviewed

Kaito Hayashi, Kurara Takagane, Go Itoh, Sei Kuriyama, Souichi Koyota, Kenji Meguro, Yiwei Ling, Tatsuya Abé, Riuko Ohashi, Masakazu Yashiro, Masaru Mizuno, Masamitsu Tanaka

British Journal of Cancer 2024.7

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Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1038/s41416-024-02783-8

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Other Link： https://www.nature.com/articles/s41416-024-02783-8
Clonal origin and genomic diversity in Lynch syndrome‐associated endometrial cancer with multiple synchronous tumors: Identification of the pathogenicity of <scp>MLH1</scp> p.<scp>L582H</scp> Reviewed

Kotaro Takahashi, Nozomi Yachida, Ryo Tamura, Sosuke Adachi, Shuhei Kondo, Tatsuya Abé, Hajime Umezu, Hiromi Nyuzuki, Shujiro Okuda, Hirofumi Nakaoka, Kosuke Yoshihara

Genes, Chromosomes and Cancer 63 ( 3 ) 2024.3

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Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Lynch syndrome‐associated endometrial cancer patients often present multiple synchronous tumors and this assessment can affect treatment strategies. We present a case of a 27‐year‐old woman with tumors in the uterine corpus, cervix, and ovaries who was diagnosed with endometrial cancer and exhibited cervical invasion and ovarian metastasis. Her family history suggested Lynch syndrome, and genetic testing identified a variant of uncertain significance, MLH1 p.L582H. We conducted immunohistochemical staining, microsatellite instability analysis, and Sanger sequencing for Lynch syndrome‐associated cancers in three generations of the family and identified consistent MLH1 loss. Whole‐exome sequencing for the corpus, cervical, and ovarian tumors of the proband identified a copy‐neutral loss of heterozygosity (LOH) occurring at the MLH1 position in all tumors. This indicated that the germline variant and the copy‐neutral LOH led to biallelic loss of MLH1 and was the cause of cancer initiation. All tumors shared a portion of somatic mutations with high mutant allele frequencies, suggesting a common clonal origin. There were no mutations shared only between the cervix and ovary samples. The profiles of mutant allele frequencies shared between the corpus and cervix or ovary indicated that two different subclones originating from the corpus independently metastasized to the cervix or ovary. Additionally, all tumors presented unique mutations in endometrial cancer‐associated genes such as ARID1A and PIK3CA. In conclusion, we demonstrated clonal origin and genomic diversity in a Lynch syndrome‐associated endometrial cancer, suggesting the importance of evaluating multiple sites in Lynch syndrome patients with synchronous tumors.

DOI： 10.1002/gcc.23231

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Hypoxia-Induced Biosynthesis of the Extracellular Matrix Molecules, Perlecan and Fibronectin, Promotes the Growth of Pleomorphic Adenoma Cells In Vitro Models Reviewed

Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Jun Cheng, Takashi Saku, Jun-ichi Tanuma

Biomedicines 11 ( 11 ) 2981 - 2981 2023.11

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Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Salivary pleomorphic adenoma is histopathologically characterized by its colorful stroma with myxoid, chondroid, and hyaline appearances, due to enhanced biosynthesis of extracellular matrix (ECM) molecules and poor vascularity. Thus, pleomorphic adenoma cells embedded in the stroma typically survive under hypoxic conditions. We determined the expression kinetics of ECM molecules, such as perlecan and fibronectin (FN), under hypoxia in SM-AP1 cells which are duct epithelial differentiated cells, and in SM-AP4 cells, which are myoepithelial differentiated cells, cloned from pleomorphic adenoma of the parotid gland. We investigated hypoxia-inducible factor-1α (HIF-1α)-inducing pathways through a variety of ECM molecules in association with their cellular proliferation and migration. We observed that hypoxic conditions with elevated HIF-1α protein levels induced increased expression of perlecan and FN in SM-AP cells than in controls. Moreover, perlecan and FN knockdown reduced the proliferation of SM-AP1 and SM-AP4 cells under hypoxia. Further, SM-AP1 cell migration was enhanced by both perlecan and FN knockdown, whereas SM-AP4 cell migration was increased by perlecan knockdown and inhibited by fibronectin knockdown. The results indicated that pleomorphic adenoma cells can survive under hypoxic conditions by promoting cell proliferation via enhanced synthesis of ECM molecules. Overall, ECM molecules may be a new anti-tumor target under hypoxic conditions.

DOI： 10.3390/biomedicines11112981

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Searching for new early detection markers of oral epithelial dysplasia and oral squamous cell carcinoma using oral liquid-based cytology Reviewed

Toshiyuki Akimori, Manabu Yamazaki, Tatsuya Abé, Satoshi Maruyama, Kei Tomihara, Takeyasu Maeda, Jun-ichi Tanuma

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2023.11

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Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.ajoms.2023.11.007

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多数の過剰歯と集合型歯牙腫を同時に認めた1例 Reviewed

相澤有香, 池田順行, 永井孝宏, 齋藤夕子, 隅田賢正, 西山秀昌, 阿部達也, 冨原圭

新潟歯学会雑誌 53 ( 1 ) 25 - 29 2023.6

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Language：Japanese Publisher：新潟歯学会

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Liquid-based cytology for differentiating two cases of pemphigus vulgaris from oral squamous cell carcinoma. Reviewed International journal

Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Yusuke Kato, Hiroyuki Kano, Yoshimasa Sumita, Kei Tomihara, Jun-Ichi Tanuma

Diagnostic cytopathology 51 ( 5 ) E170-E175 2023.5

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Pemphigus vulgaris (PV) is a rare autoimmune disease characterized by blisters on the skin and mucous membrane. Since it often appears in the oral mucosa first, it may be diagnosed by oral mucosal cytology. Although the cytologic finding is characterized by acantholytic cells, that is, Tzanck cells, it is important to distinguish PV from neoplastic lesions of the oral mucosal epithelium, including differentiation from atypical parabasal/basal cells, which appear in squamous cell carcinoma (SCC). In this study, we examined the cellular findings in two cases of PV and a case of well-differentiated SCC with loss of epithelial cell cohesion. The samples were prepared using liquid-based cytology, which showed small round-shaped and deeply stained atypical, orangeophilic keratinocytes not only in SCC but also in PV, which made differentiation between the two difficult. However, Tzanck cells found in PV differ from the deep atypical parabasal/basal cells of SCC, suggesting that the cell outline is indistinct and small protrusions and brush-like structures are observed. This feature of Tzanck cells may be useful in cytological judgment.

DOI： 10.1002/dc.25117

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Cholesterol Is a Regulator of CAV1 Localization and Cell Migration in Oral Squamous Cell Carcinoma Invited Reviewed

Nyein Nyein Chan, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Kenta Haga, Masami Kawaharada, Kenji Izumi, Tadaharu Kobayashi, Jun-ichi Tanuma

International Journal of Molecular Sciences 24 ( 7 ) 6035 2023.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3390/ijms24076035

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Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review Reviewed International journal

Tatsuya Abé, Manabu Yamazaki, Satoshi Maruyama, Nobuyuki Ikeda, Yoshimasa Sumita, Kei Tomihara, Jun-ichi Tanuma

Diagnostics 12 ( 10 ) 2398 - 2398 2022.10

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Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Adenosquamous carcinoma (ASC) is an aggressive subtype of squamous cell carcinoma (SCC). Due to its poor prognosis, a precise pathological diagnosis of ASC is essential but challenging because its pathological criteria are still unclear. Here, we present a rare case of oral ASC accompanied by acantholytic features. The tumor was raised in the mandibular gingiva and recurred locally approximately 13 months after the initial surgery with cervical lymph node metastasis. Pathological specimens of the primary lesion showed acantholysis in a large area of the SCC. Mucous cells, the characteristic finding indicating glandular differentiation, were imperceptible in the initial surgical specimen but increased in the locally recurrent and metastatic lymph node specimens. In a comprehensive literature review of oral ASC cases, the present case was the only case of ASC with acantholytic features. We reconfirmed that ASC has poor prognoses, such as low 5-year overall survival and disease-free survival, high locoregional recurrence, and high distant metastasis rates. A precise diagnosis of ASC is required for estimating prognosis and undergoing close follow-up, even if the adenocarcinomatous component is limited to a small area in the lesion.

DOI： 10.3390/diagnostics12102398

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Clinicopathologic factors influencing the screening accuracy of oral cytology: A retrospective cohort study Reviewed

Masami Kawaharada, Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Nyein Chan, Akinori Funayama, Atsushi Uenoyama, Toshiyuki Akimori, Kei Tomihara, Jun-Ichi Tanuma

Oncology Letters 24 ( 5 ) 2022.9

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Publishing type：Research paper (scientific journal) Publisher：Spandidos Publications

DOI： 10.3892/ol.2022.13505

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Novel cytological model for the identification of early oral cancer diagnostic markers: The carcinoma sequence model. Reviewed International journal

Masami Kawaharada, Manabu Yamazaki, Satoshi Maruyama, Tatsuya AbÉ, Nyein Nyein Chan, Taiichi Kitano, Tadaharu Kobayashi, Takeyasu Maeda, Jun-Ichi Tanuma

Oncology letters 23 ( 3 ) 76 - 76 2022.3

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Most oral squamous cell carcinomas (OSCCs) arise from a premalignant lesion, oral epithelial dysplasia; however, useful markers for the early detection of OSCC are lacking. The present study aimed to establish a novel experimental model to observe changes in the sequential expression patterns of mRNAs and proteins in a rat model of tongue cancer using liquid-based cytology techniques. Cytology specimens were collected at 2, 5, 8, 11, 14, 17 and 21 weeks from rats treated with 4-nitroquinoline 1-oxide to induce tongue cancer. The expression of candidate biomarkers was examined by performing immunocytochemistry and reverse transcription-quantitative PCR. The percentage of positively stained nuclei was calculated as the labeling index (LI). All rats developed OSCC of the tongue at 21 weeks. The mRNA expression levels of bromodomain protein 4 (Brd4), c-Myc and Tp53 were upregulated during the progression from negative for intraepithelial lesion or malignancy to squamous cell carcinoma (SCC). Brd4- and c-Myc-LI increased in low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion and SCC specimens. p53-LI was significantly increased in SCC specimens. This novel experimental model allowed the observation of sequential morphological changes and the expression patterns of mRNAs and proteins during carcinogenesis. Combining immunocytochemistry with cytology-based diagnoses may potentially improve the diagnostic accuracy of OSCC.

DOI： 10.3892/ol.2022.13196

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Metastasis of pulmonary adenocarcinoma to the oral cavity: A case report and literatures review of the last 30 years Reviewed

Masami Kawaharada, Satoshi Maruyama, Tatsuya Abé, Takafumi Hayashi, Tadaharu Kobayashi, Jun‐ichi Tanuma

Oral Science International 2022.1

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Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1002/osi2.1130

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1130
Melanotic neuroectodermal tumor of infancy in the mandible: A case report. Reviewed International journal

Ryoko Takeuchi, Akinori Funayama, Yohei Oda, Tatsuya Abé, Manabu Yamazaki, Satoshi Maruyama, Takafumi Hayashi, Jun-Ichi Tanuma, Tadaharu Kobayashi

Medicine 100 ( 50 ) e28001 2021.12

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Language：English Publishing type：Research paper (scientific journal)

RATIONALE: Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare benign pigmented neoplasm that arises from the neural crest and has an aggressive growth pattern. It is predominantly seen in infants under 1 year of age, and the most common site of involvement is the maxilla. The currently accepted treatment is removal by surgical resection. Herein, we report a case of MNTI that involved the anterior alveolar ridge of the mandible in a 6-month-old infant. PATIENT CONCERNS: A case of a 6-month-old male child with a huge mass in the anterior alveolar ridge of the mandible. DIAGNOSIS: The tumor was diagnosed using histopathological and immunohistochemical techniques on the biopsy specimen obtained following incisional biopsy. Based on the findings, a final diagnosis of MNTI was established. INTERVENTIONS: Radical resection of the tumor was performed, after determining the extent of resection by referring to the mandibular 3D model created using the pre-operative CT data. OUTCOMES: The postoperative course was uneventful, and no recurrence has been observed to date for more than 4 years after surgery. LESSONS: This case emphasizes that early diagnosis and radical surgery are critical to the effective treatment, as MNTI exhibits rapid and destructive growth. It also requires careful and close follow-up because of high recurrence rates.

DOI： 10.1097/MD.0000000000028001

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術前化学放射線療法後に腹腔鏡下腹会陰式直腸切断術を施行した痔瘻癌の1例 Reviewed

田中花菜, 中野麻恵, 島田能史, 阿部達也, 梅津哉, 松本瑛生, 荒引みちる, 阿部馨, 小柳英人, 中野雅人, 平井裕美子, 大関瑛, 茂木大輔, 峠弘治, 山本潤, 三浦宏平, 市川寛, 滝沢一泰, 坂田純, 小林隆, 若井俊文

癌と化学療法 48 ( 12 ) 1515 - 1517 2021.12

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Language：Japanese Publisher：(株)癌と化学療法社

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J00296&link_issn=&doc_id=20211216370020&doc_link_id=%2Fab8gtkrc%2F2021%2F004812%2F021%2F1515b1517%26dl%3D3&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2021%2F004812%2F021%2F1515b1517%26dl%3D3&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_4.gif
Spindle cell squamous cell carcinoma exhibiting prominent neutrophil phagocytosis: a case report. Reviewed International journal

Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Yoshimasa Sumita, Yuji Katsumi, Yutaka Nikkuni, Takafumi Hayashi, Jun-Ichi Tanuma

Journal of medical case reports 15 ( 1 ) 438 - 438 2021.8

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Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Spindle cell squamous cell carcinoma is an uncommon variant of squamous cell carcinoma; its diagnosis is sometimes challenging because it histopathologically resembles neoplastic or reactive spindle cell lesions of mesenchymal origins. Here, we report a rare case of spindle cell squamous cell carcinoma exhibiting prominent neutrophil phagocytosis. CASE PRESENTATION: A 69-year-old Japanese man presented with pain and a polypoid mass on the lower left gingiva. He had received chemoradiotherapy for squamous cell carcinoma of the buccal mucosa 15 years prior to this consultation. In addition, he was treated for mandibular osteonecrosis 6 years after chemoradiotherapy without evidence of cancer recurrence. A biopsy revealed atypical spindle or pleomorphic cells scattered in the edematous and fibrin-rich stroma; however, no malignant squamous components were apparent. These atypical cells frequently contained neutrophils within their cytoplasm that formed cell-in-cell figures. Immunohistochemically, the atypical cells were negative for cytokeratins, epithelial membrane antigen, and E-cadherin, but positive for p63, vimentin, and p53. Although these findings suggested spindle cell squamous cell carcinoma, it was difficult to reach a definitive diagnosis. Based on a clinical diagnosis of a malignant tumor, the patient underwent a hemimandibulectomy. The surgically resected specimen had a typical spindle cell squamous cell carcinoma histology consisting of biphasic spindle cells and conventional squamous cell carcinoma components. Moreover, the surgical specimen also exhibited spindle tumor cells that frequently included neutrophils, around which intense staining for lysosomal-associated membrane protein 1 and cathepsin B was observed. This suggested that the cell-in-cell figures represent active neutrophil phagocytosis by tumor cells, and not emperipolesis. CONCLUSION: The presence of neutrophil phagocytosis may be a potent indicator of malignancy.

DOI： 10.1186/s13256-021-03066-z

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Central mucoepidermoid carcinoma arising directly from a glandular odontogenic cyst of the mandible: a case report. Reviewed International journal

Satoshi Maruyama, Taisuke Mori, Manabu Yamazaki, Tatsuya Abé, Eijitsu Ryo, Hiroyuki Kano, Go Hasegawa, Jun-Ichi Tanuma

Diagnostic pathology 16 ( 1 ) 61 - 61 2021.7

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BACKGROUND: Central mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jawbone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Here, we present a rare case of central MEC developed directly from a pre-existing GOC of the mandible. CASE PRESENTATION: A 67-year-old Japanese man presented with a cystic lesion in the right third molar region. Histologically, the biopsy specimen demonstrated both typical findings of a GOC component lined with non-keratinized squamous epithelium and a recognizable component of central MEC consisting of polycystic nests with mucous cells, intermediate cells, and epidermoid cells in the cyst wall. The results from the immunohistochemistry for cytokeratin (CK) profiling demonstrated that, while both central MEC and GOC expressed CKs 7, 14, 18, and 19, CK13 was interestingly exclusively expressed in GOC. Fluorescence in-situ hybridization (FISH) revealed the rearrangement of the Mastermind like (MAML)-2 gene in both the MEC and GOC components. CONCLUSIONS: Our case suggests that central MEC and GOC may be in the same spectrum of diseases caused by the rearrangement of the MAML-2 gene. However, given that the expression profile of CK13 was completely different between central MEC and GOC, they can be considered as separate tumors. Overall, we demonstrated a rare case in which central MEC may have originated directly from the GOC.

DOI： 10.1186/s13000-021-01124-0

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Other iatrogenic immunodeficiency-associated lymphoproliferative disorders in the oral cavity: a clinicopathologic study of 4 cases and literature review. Reviewed International journal

Masami Kawaharada, Satoshi Maruyama, Tatsuya Abé, Manabu Yamazaki, Akira Kurokawa, Wataru Katagiri, Ritsuo Takagi, Takafumi Hayashi, Tadaharu Kobayashi, Jun-Ichi Tanuma

Oral surgery, oral medicine, oral pathology and oral radiology 132 ( 6 ) 687 - 697 2021.6

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OBJECTIVES: Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OI-LPD) have been reported as one of the adverse effects of immunosuppressive therapy. The aim of this study was to describe the clinicopathologic and immunohistochemical features of OI-LPD in the oral cavity. STUDY DESIGN: Immunohistochemistry was performed to describe the immunohistochemical features in our 4 cases. The results were analyzed along with 62 cases of oral OI-LPD in the English and Japanese literature to define clinical and pathologic characteristic features. RESULTS: In our immunohistochemical analysis, Epstein-Barr virus (EBV)-positive OI-LPD showed a higher percentage of mouse double minute 2-positive cells than EBV-negative samples. A literature survey revealed that OI-LPD (including the present cases) arises primarily in the gingiva, followed by the tongue, and usually occurs with a male-to-female ratio of 1:1.9. The rate of EBV positivity was 93.8%. Further, 31 of 66 patients had osteonecrosis of the jaw and 24 of 31 patients had taken multiple immunosuppressive drugs in combination. CONCLUSIONS: We can therefore conclude that the overexpression of mouse double minute 2 in OI-LPD is associated with EBV infection, and the combination of multiple immunosuppressive drugs may be a risk factor for osteonecrosis of the jaw.

DOI： 10.1016/j.oooo.2021.05.015

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Disseminated Varicella-zoster Virus Infection Causing Fatal Pneumonia in an Immunocompromised Patient with Chronic Interstitial Pneumonia: A Case Report Reviewed

Hiroshi Ueno, Masachika Hayashi, Shun Nagumo, Kosuke Ichikawa, Nobumasa Aoki, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Tatsuya Abé, Riuko Ohashi, Yoichi Ajioka, Toshiaki Kikuchi

Internal Medicine 2021

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Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Internal Medicine

DOI： 10.2169/internalmedicine.5396-20

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病変の広がり診断に苦慮した腋窩副乳原発浸潤性小葉癌の1例 Reviewed

大関瑛, 利川千絵, 諸和樹, 長谷川遥, 土田純子, 五十嵐麻由子, 永橋昌幸, 勝見茉耶, 中島順子, 阿部達也, 谷優佑, 坂田純, 梅津哉, 松田健, 若井俊文

癌と化学療法 47 ( 13 ) 2044 - 2046 2020.12

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Language：Japanese Publisher：(株)癌と化学療法社

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00296&link_issn=&doc_id=20210118600102&doc_link_id=%2Fab8gtkrc%2F2020%2F004713%2F102%2F2044b2046%26dl%3D3&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2020%2F004713%2F102%2F2044b2046%26dl%3D3&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_4.gif
17年を経過して再減量手術を行った上顎骨線維性異形成症の1例

伊藤元貴, 児玉泰光, 大貫尚志, 高村真貴, 林孝文, 阿部達也, 田沼順一, 小林正治, 高木律男

新潟歯学会雑誌 50 ( 2 ) 79 - 85 2020.12

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Language：Japanese Publisher：新潟歯学会

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Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients Reviewed International journal

Riuko Ohashi, Hajime Umezu, Ayako Sato, Tatsuya Abé, Shuhei Kondo, Kenji Daigo, Seijiro Sato, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Teiichi Motoyama, Masashi Kishi, Tadahiro Nagaoka, Keiko Horiuchi, Atsushi Shiga, Shujiro Okuda, Tomoki Sekiya, Aya Ohtsubo, Kosuke Ichikawa, Hiroshi Kagamu, Toshiaki Kikuchi, Satoshi Watanabe, Jun-Ichi Tanuma, Peter Schraml, Takao Hamakubo, Masanori Tsuchida, Yoichi Ajioka

Cells 9 ( 11 ) 2409 - 2409 2020.11

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Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Ribosomal RNA (rRNA), the most abundant non-coding RNA species, is a major component of the ribosome. Impaired ribosome biogenesis causes the dysfunction of protein synthesis and diseases called “ribosomopathies,” including genetic disorders with cancer risk. However, the potential role of rRNA gene (rDNA) alterations in cancer is unknown. We investigated germline and somatic single-nucleotide variants (SNVs) in the rDNA promoter region (positions −248 to +100, relative to the transcription start site) in 82 lung adenocarcinomas (LUAC). Twenty-nine tumors (35.4%) carried germline SNVs, and eight tumors (9.8%) harbored somatic SNVs. Interestingly, the presence of germline SNVs between positions +1 and +100 (n = 12; 14.6%) was associated with significantly shorter recurrence-free survival (RFS) and overall survival (OS) by univariate analysis (p < 0.05, respectively), and was an independent prognostic factor for RFS and OS by multivariate analysis. LUAC cell line PC9, carrying rDNA promoter SNV at position +49, showed significantly higher ribosome biogenesis than H1650 cells without SNV. Upon nucleolar stress induced by actinomycin D, PC9 retained significantly higher ribosome biogenesis than H1650. These results highlight the possible functional role of SNVs at specific sites of the rDNA promoter region in ribosome biogenesis, the progression of LUAC, and their potential prognostic value.

DOI： 10.3390/cells9112409

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Keratin 17-positive Civatte bodies in oral lichen planus—distribution variety, diagnostic significance and histopathogenesis Reviewed International journal

Tatsuya Abé, Norio Kitagawa, Shohei Yoshimoto, Satoshi Maruyama, Manabu Yamazaki, Tetsuichiro Inai, Shuichi Hashimoto, Takashi Saku

Scientific Reports 10 ( 1 ) 14586 - 14586 2020.9

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Although emergence of keratin 17 (K17) and reciprocal loss of K13 are immunohistochemical hallmarks for oral mucosal malignancy, we report here findings of K17-positive (+) speckles, possibly equivalent to Civatte bodies, in benign oral lichen planus. Sixty-two biopsy samples from oral lichen planus cases were subjected to immunohistochemical examinations to analyze the distribution as well as histopathogenesis of Civatte bodies. K17 was irregularly positive among oral lichen planus-affected epithelial cells, and K17-positive (+) filamentous structures were irregularly distributed within the cytoplasm in confocal images. K17+ speckles were identified as Civatte bodies, and they were mainly distributed in the interface between epithelial cells and lymphocytic infiltrates (type A, 52.8%), followed by distribution within the epithelial layer (type B, 24.7%) or within the lamina propria with lymphocytic infiltration (type C, 22.5%). Apoptotic figures were often engulfed by macrophages and clearly distinguished from Civatte bodies by the presence TUNEL signals. These results indicate that K17 is a sensitive immunohistochemical marker for Civatte bodies and useful for differential diagnosis of oral lichen planus from other oral mucosal lesions. Civatte bodies are generated from denucleation of K17+ epithelial cells during the process of cell death via dyskeratosis, which is possibly related to blood capillary collapse.

DOI： 10.1038/s41598-020-71496-8

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Other Link： http://www.nature.com/articles/s41598-020-71496-8
Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression. Reviewed International journal

Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Masayuki Tsuneki, Hiroko Kato, Kenji Izumi, Jun-Ichi Tanuma, Jun Cheng, Takashi Saku

Experimental cell research 392 ( 1 ) 112013 - 112013 2020.4

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Apoptotic cell death frequently occurs in human cancer tissues including oral squamous cell carcinoma (SCC), wherein apoptotic tumor cells are phagocytosed not only by macrophages but also by neighboring tumor cells. We previously reported that the engulfment of apoptotic SCC cells by neighboring SCC cells frequently occurs at the invading front. Therefore, we hypothesized that the phagocytosis of these apoptotic cells by tumor cells contributes to disease progression. Herein, using cultured oral SCC cells, we aimed to confirm whether tumor cells actually phagocytose apoptotic cells and to examine whether cellular activities are regulated by the phagocytosis of apoptotic cells. Co-culture experiments showed that living cells could ingest apoptotic cells into phagolysosomes. NSC23766, an inhibitor of Rac1, which is a key regulator of phagocytic cup formation in professional phagocytes, dramatically suppressed the phagocytosis of apoptotic cells by living cells. Additionally, cell migration and the secretion of DKK1, a tumor-promoting protein, were enhanced by co-culture with apoptotic cells, whereas NSC23766 inhibited these effects. These results show that tumor cells can actively phagocytose apoptotic neighbors in a Rac1-dependent manner and that such activity increases their migration. The regulation of apoptotic cell phagocytosis thus represents new directions for therapeutic intervention for oral cancer.

DOI： 10.1016/j.yexcr.2020.112013

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Portal Vein Thrombosis Associated with Trousseau Syndrome due to Urinary Bladder Squamous Cell Carcinoma in a Liver Cirrhosis Patient Reviewed

Kimura Naruhiro, Terai Shuji, Tsuchiya Atsunori, Oda Chiyumi, Kimura Atsushi, Hosaka Kazunori, Tominaga Kentaro, Hayashi Kazunao, Abé Tatsuya, Umezu Hajime

Internal Medicine 59 ( 16 ) 1971 - 1975 2020

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Language：English Publisher：The Japanese Society of Internal Medicine

A 75-year-old woman with liver cirrhosis was admitted for treatment of portal vein thrombosis (PVT). Computed tomography (CT) showed PVT, massive ascites, and multiple abdominal organ embolism. Blood tests revealed a decreased liver function (Child-Pugh grade C). Language impairment followed by progressive left hemi-paralysis was subsequently detected. Magnetic resonance imaging revealed multiple small acute cerebral infarctions and, on CT, a 30-mm bladder tumour; a biopsy specimen examination showed squamous cell carcinoma. Her general condition worsened rapidly, and the best supportive care was chosen. Our findings suggest that, in patients with PVT, Trousseau syndrome should be considered, even in cases of liver cirrhosis. 

DOI： 10.2169/internalmedicine.4112-19

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Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma. Reviewed International journal

Yoshimasa Sumita, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Jun Cheng, Ritsuo Takagi, Jun-Ichi Tanuma

Oncology reports 40 ( 5 ) 2487 - 2496 2018.11

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Transcription factor SRY‑box 9 (SOX9) is a key regulator of chondrocyte differentiation and sex determination, and it is also involved in the progression of various types of human cancer. However, its putative association with oral squamous cell carcinoma (OSCC) remains elusive. The aim of the present study was to investigate the expression profiles of SOX9 in various oral epithelial lesions, including OSCC. We performed immunohistochemical analysis of SOX9 expression in surgical specimens of OSCC, which simultaneously exhibited different grades of epithelial lesions, and analyzed the correlation between SOX9 expression and several clinicopathological factors. Moreover, we performed immunofluorescent staining, western blot analysis and real‑time reverse transcription‑polymerase chain reaction to assess SOX9 expression in OSCC HSC‑3 (a metastatic cell line) and HSC‑4 (a non‑metastatic cell line) cell lines. In surgical specimens, SOX9 expression was detected in the nuclei of proliferating cells in areas with epithelial dysplasia and carcinoma in situ, but not in areas with normal epithelia. Nuclear SOX9 expression was observed in most SCC cells. Notably, cytoplasmic SOX9 expression was confirmed only in some SCC cells; however, cytoplasmic SOX9 expression was significantly and positively correlated with poor clinical outcomes. Both protein and mRNA expression of SOX9 were significantly higher in the HSC‑3 cell line than that in the HSC‑4 line. Notably, however, only HSC‑3 cells exhibited cytoplasmic localization of SOX9 expression. Our findings indicate that SOX9 may be involved in the tumorigenesis and progression of OSCC. Furthermore, its cytoplasmic expression represents a potential predictive biomarker for tumor aggressiveness and OSCC prognosis.

DOI： 10.3892/or.2018.6665

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A Case of Panenteritis With Massive IgG4-Positive Plasma Cell Infiltration Developed 26 Years After Total Proctocolectomy for Ulcerative Colitis. Reviewed International journal

Kentaro Tominaga, Atsunori Tsuchiya, Yutaka Honda, Tatsuya Abe, Junji Yokoyama, Hajime Umezu, Shuji Terai

The American journal of gastroenterology 113 ( 2 ) 173 - 173 2018.2

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DOI： 10.1038/ajg.2017.481

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An unusual and difficult diagnosis of synovial chondromatosis: A case report Reviewed

Toshihiko Mikami, Yusuke Kato, Taku Kojima, Tatsuya Abe, Satoshi Maruyama, Hideyoshi Nishiyama, Takafumi Hayashi, Tadaharu Kobayashi

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 30 ( 5 ) 422 - 427 2018

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DOI： 10.1016/j.ajoms.2018.03.006

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Proteomic and histopathological characterization of the interface between oral squamous cell carcinoma invasion fronts and non-cancerous epithelia Reviewed

Tatsuya Abé, Satoshi Maruyama, Manabu Yamazaki, Bo Xu, Hamzah Babkair, Yoshimasa Sumita, Jun Cheng, Tadashi Yamamoto, Takashi Saku

Experimental and Molecular Pathology 102 ( 2 ) 327 - 336 2017.4

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DOI： 10.1016/j.yexmp.2017.02.018

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Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma Reviewed

Hamzah Babkair, Manabu Yamazaki, Md. Shihab Uddin, Satoshi Maruyama, Tatsuya Abe, Ahmed Essa, Yoshimasa Sumita, Md. Shahidul Ahsan, Wael Swelam, Jun Cheng, Takashi Saku

HUMAN PATHOLOGY 57 51 - 60 2016.11

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DOI： 10.1016/j.humpath.2016.07.001

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Tumour-associated macrophages are recruited and differentiated in the neoplastic stroma of oral squamous cell carcinoma Reviewed

Ahmed Abdelaziz Mohamed Essa, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abe, Hamzah Babkair, Adel Mohamed Raghib, Eman Money El-Din Megahed, Jun Cheng, Takashi Sakui

PATHOLOGY 48 ( 3 ) 219 - 227 2016.4

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DOI： 10.1016/j.pathol.2016.02.006

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Differential immunohistochemical expression profiles of perlecan-binding growth factors in epithelial dysplasia, carcinoma in situ, and squamous cell carcinoma of the oral mucosa Reviewed

Mayumi Hasegawa, Jun Cheng, Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abe, Hamzah Babkair, Chikara Saito, Takashi Saku

PATHOLOGY RESEARCH AND PRACTICE 212 ( 5 ) 426 - 436 2016

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DOI： 10.1016/j.prp.2016.02.016

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Simultaneous immunolocalization of desmoglein 3 and IgG4 in oral pemphigus vulgaris: IgG4 predominant autoantibodies in its pathogenesis Reviewed

Ab{\'e}, T., Maruyama, S., Babkair, H., Yamazaki, M., Cheng, J., Saku, T.

Journal of Oral Pathology and Medicine 44 ( 10 ) 850 - 856 2015.11

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DOI： 10.1111/jop.12290

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Mandibular osteonecrosis in a patient receiving Denosumab and Sunitinib. Reviewed

Tanaka R, Saito M, Abé T, Ajima H, Saku T, Hayashi T

Journal of Medical Cases 6 ( 9 ) 393 - 398 2015.9

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Paradental cyst is an inclusion cyst of the junctional/sulcular epithelium of the gingiva: histopathologic and immunohistochemical confirmation for its pathogenesis Reviewed

Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abe, Hamzah Babkair, Jun Cheng, Takashi Saku

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 120 ( 2 ) 227 - 237 2015.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.oooo.2015.04.001

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Protease-activated receptor 2 modulates proliferation and invasion of oral squamous cell carcinoma cells Reviewed

Kamal Al-Eryani, Jun Cheng, Tatsuya Abe, Satoshi Maruyama, Manabu Yamazaki, Hamzah Babkair, Ahmed Essa, Takashi Saku

HUMAN PATHOLOGY 46 ( 7 ) 991 - 999 2015.7

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DOI： 10.1016/j.humpath.2015.03.003

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Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration Reviewed

Toshihiko Mikami, Satoshi Maruyama, Tatsuya Abe, Takanori Kobayashi, Manabu Yamazaki, Akinori Funayama, Susumu Shingaki, Tadaharu Kobayashi, Cheng Jun, Takashi Saku

VIRCHOWS ARCHIV 466 ( 5 ) 559 - 569 2015.5

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DOI： 10.1007/s00428-015-1735-6

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MFG-E8 expression for progression of oral squamous cell carcinoma and for self-clearance of apoptotic cells Reviewed

Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abe, Ahmed Essa, Hamzah Babkair, Jun Cheng, Takashi Saku

LABORATORY INVESTIGATION 94 ( 11 ) 1260 - 1272 2014.11

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DOI： 10.1038/labinvest.2014.108

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Keratin pearl degradation in oral squamous cell carcinoma: reciprocal roles of neutrophils and macrophages Reviewed

Ahmed A. M. Essa, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abe, Hamzah Babkair, Jun Cheng, Takashi Saku

JOURNAL OF ORAL PATHOLOGY & MEDICINE 43 ( 10 ) 778 - 784 2014.11

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DOI： 10.1111/jop.12197

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Perlecan-enriched intercellular space of junctional epithelium provides primary infrastructure for leukocyte migration through squamous epithelial cells Reviewed

Satoshi Maruyama, Manami Itagaki, Hiroko Ida-Yonemochi, Takehiko Kubota, Manabu Yamazaki, Tatsuya Abe, Hiromasa Yoshie, Jun Cheng, Takashi Saku

HISTOCHEMISTRY AND CELL BIOLOGY 142 ( 3 ) 297 - 305 2014.9

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00418-014-1198-x

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Three-dimensional visualization of perlecan-rich neoplastic stroma induced concurrently with the invasion of oral squamous cell carcinoma Reviewed

Satoshi Maruyama, Yoshihito Shimazu, Tomoo Kudo, Kaori Sato, Manabu Yamazaki, Tatsuya Abe, Hamzah Babkair, Jun Cheng, Takaaki Aoba, Takashi Saku

JOURNAL OF ORAL PATHOLOGY & MEDICINE 43 ( 8 ) 627 - 636 2014.9

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DOI： 10.1111/jop.12184

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Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature Reviewed

Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abe, Hamzah Babkair, Hajime Fujita, Ritsuo Takagi, Jun-ichi Koyama, Takafumi Hayashi, Jun Cheng, Takashi Saku

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 118 ( 1 ) E12 - E18 2014.7

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DOI： 10.1016/j.oooo.2013.08.032

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Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: Differential diagnosis by immunohistochemistry Reviewed

Ab{\'e}, T., Maruyama, S., Yamazaki, M., Essa, A., Babkair, H., Mikami, T., Shingaki, S., Kobayashi, T., Hayashi, T., Cheng, J., Saku, T.

Human Pathology 45 ( 1 ) 110 - 118 2014.1

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DOI： 10.1016/j.humpath.2013.08.011

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Intraoperative Assessment of Surgical Margins of Oral Squamous Cell Carcinoma Using Frozen Sections: A Practical Clinicopathological Management for Recurrences Reviewed

Shun Miyota, Takanori Kobayashi, Tatsuya Abe, Hisashi Miyajima, Masaki Nagata, Hideyuki Hoshina, Tadaharu Kobayashi, Ritsuo Takagi, Takashi Saku

BIOMED RESEARCH INTERNATIONAL 2014 823968 2014

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DOI： 10.1155/2014/823968

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Radiation-induced undifferentiated high-grade pleomorphic sarcoma (malignant fibrous histiocytoma) of the mandible: Report of a case arising in the background of long-standing osteomyelitis with a review of the literature Reviewed

Takahiro Koyama, Takanori Kobayashi, Satoshi Maruyama, Tatsuya Abe, Wael Mohamed Swelam, Yasumitu Kodama, Hideyuki Hoshina, Ritsuo Takagi, Takafumi Hayashi, Takashi Saku

PATHOLOGY RESEARCH AND PRACTICE 210 ( 12 ) 1123 - 1129 2014

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DOI： 10.1016/j.prp.2014.06.028

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Hemophagocytosis-mediated keratinization in oral carcinoma in situ and squamous cell carcinoma: A possible histopathogenesis of keratin pearls Reviewed

Kamal Al-Eryani, Jun Cheng, Tatsuya Abe, Manabu Yamazaki, Satoshi Maruyama, Masayuki Tsuneki, Ahmed Essa, Hamzah Babkair, Takashi Saku

JOURNAL OF CELLULAR PHYSIOLOGY 228 ( 10 ) 1977 - 1988 2013.10

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DOI： 10.1002/jcp.24364

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Central neurofibroma of the mandible: Report of a case and review of the literature Reviewed

Hamdy Metwaly, Jun Cheng, Satoshi Maruyama, Manabu Yamazaki, Ahmed Essa, Tatsuya Abé, Hamzah Babkair, Hideyuki Hoshina, Ritsuo Takagi, Takafumi Hayashi, Takashi Saku

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 25 ( 3 ) 294 - 298 2013.7

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DOI： 10.1016/j.ajoms.2012.12.002

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Inflammatory histopathogenesis of nasopalatine duct cyst: a clinicopathological study of 41 cases Reviewed

M. Tsuneki, S. Maruyama, M. Yamazaki, T. Abe, H. A. Adeola, J. Cheng, H. Nishiyama, T. Hayashi, T. Kobayashi, R. Takagi, A. Funayama, C. Saito, T. Saku

ORAL DISEASES 19 ( 4 ) 415 - 424 2013.5

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DOI： 10.1111/odi.12022

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Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells Reviewed

Masayuki Tsuneki, Satoshi Maruyama, Manabu Yamazaki, Bo Xu, Ahmed Essa, Tatsuya Abé, Hamzah Babkair, Jun Cheng, Tadashi Yamamoto, Takashi Saku

Biochemical and Biophysical Research Communications 434 ( 1 ) 124 - 130 2013.4

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DOI： 10.1016/j.bbrc.2013.03.057

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Podoplanin is a novel myoepithelial cell marker in pleomorphic adenoma and other salivary gland tumors with myoepithelial differentiation Reviewed

Masayuki Tsuneki, Satoshi Maruyama, Manabu Yamazaki, Ahmed Essa, Tatsuya Abe, Hamzah Ali Babkair, Md Shahidul Ahsan, Jun Cheng, Takashi Saku

VIRCHOWS ARCHIV 462 ( 3 ) 297 - 305 2013.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00428-012-1359-z

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Parenchymal-stromal switching for extracellular matrix production on invasion of oral squamous cell carcinoma Reviewed

Hamdy Metwaly, Satoshi Maruyama, Manabu Yamazaki, Masayuki Tsuneki, Tatsuya Abe, Kai Yu Jen, Jun Cheng, Takashi Saku

HUMAN PATHOLOGY 43 ( 11 ) 1973 - 1981 2012.11

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DOI： 10.1016/j.humpath.2012.02.006

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Keratin 10-positive orthokeratotic dysplasia: a new leucoplakia-type precancerous entity of the oral mucosa Reviewed

Takanori Kobayashi, Satoshi Maruyama, Tatsuya Abe, Jun Cheng, Ritsuo Takagi, Chikara Saito, Takashi Saku

HISTOPATHOLOGY 61 ( 5 ) 910 - 920 2012.11

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DOI： 10.1111/j.1365-2559.2012.04283.x

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歯学生のための基礎病理学

（ Role： Contributor , 下部消化管 pp. 287-289）

医歯薬出版株式会社 2024.5 （ ISBN:9784263456750 ）

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口腔癌診療ガイドライン

口腔癌診療ガイドライン改訂合同委員会, 日本口腔腫瘍学会「口腔癌診療ガイドライン」改定委員会, 日本口腔外科学会口腔癌診療ガイドライン策定小委員会

金原出版 2023.11 （ ISBN:9784307450157 ）

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Total pages：xi, 221p Language：Japanese

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MISC

Development of animal models for cancer cachexia and strategies to improve the quality of life in sarcopenia

Junichi Tanuma, Satoshi Maruyama, Tatsuya Abe, Kenta Haga, Alex Kesuma, Maiko Kawasaki, Manabu Yamazaki

CANCER SCIENCE 117 375 - 375 2026.1

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Pathology of Colorectal carcinomas

45 ( 7 ) 634 - 643 2025.5

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

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口腔扁平上皮癌の側方上皮内進展と間質浸潤：病理学的解析とその相反制御に関わる因子

阿部達也

Medical Science Digest 51 ( 1 ) 54 - 55 2025.1

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頭頸部扁平上皮癌におけるmRNAスプライシングシグネチャーと病理学的意義の探索(Alternative splicing signatures of mRNA in head and neck squamous cell carcinoma and pathological significance)

阿部達也, 凌一葦, 奥田修二郎, 山崎学, 丸山智, 田沼順一

日本癌学会総会記事 83回 P - 2222 2024.9

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口腔扁平上皮癌における異所性核酸受容分子の発現解析(Expression of heterotopic nucleic acid-sensing molecules in oral squamous cell carcinoma)

山崎学, 阿部達也, 丸山智, 田沼順一

日本病理学会会誌 113 ( 1 ) 351 - 351 2024.2

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頭頸部扁平上皮癌における選択的スプライシングシグネチャーによる予後予測(Prediction of prognosis by alternative splicing signature in head and neck squamous cell carcinoma)

阿部達也, 凌一葦, 奥田修二郎, 山崎学, 丸山智, 田沼順一

日本病理学会会誌 113 ( 1 ) 296 - 296 2024.2

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良性および悪性唾液腺腫瘍の診断におけるCD73免疫組織化学的検索(CD73 immunohistochemical analysis for the diagnosis of benign and malignant salivary gland tumors)

丸山智, 山崎学, 阿部達也, 田沼順一

日本病理学会会誌 113 ( 1 ) 351 - 351 2024.2

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患者由来がん関連線維芽細胞を含む3次元口腔がんモデルの開発とその特徴解析

相澤有香, 相澤有香, 羽賀健太, 吉羽永子, WITSANU Yortchan, 高田翔, 田中凛太郎, 内藤絵里子, 阿部達也, 丸山智, 山崎学, 田沼順一, 冨原圭, 泉健次

新潟歯学会雑誌 54 ( 2 ) 2024

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J-GLOBAL

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光干渉断層撮影を用いた3次元口腔癌モデルにおける癌浸潤の定量解析(Quantitative analysis of cancer cell invasion on 3D in vitro oral cancer models using optical coherence tomography)

羽賀健太, 山崎学, 丸山智, 阿部達也, 小林正治, 田沼順一

日本癌学会総会記事 82回 970 - 970 2023.9

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同種死細胞により誘導される口腔扁平上皮癌細胞の活性化メカニズム(Dead cancer cell-induced activation mechanisms of oral squamous cell carcinoma cells)

山崎学, 阿部達也, 丸山智, 田沼順一

日本癌学会総会記事 82回 233 - 233 2023.9

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頭頸部扁平上皮癌における特異的選択的スプライシングの探索データベース解析とロングリード-ケンシング(Alternative splicing in head and neck squamous cell carcinoma: public database exploration and long-read sequencing)

阿部達也, 凌一葦, 奥田修二郎, 山崎学, 丸山智, 田沼順一

日本癌学会総会記事 82回 1083 - 1083 2023.9

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広基性鋸歯状病変(Sessile serrated lesion)の癌化過程の形態学・免疫組織化学・遺伝子解析による検討

高村佳緒里, 味岡洋一, 大橋瑠子, 阿部達也, 谷優佑, 近藤修平, 田口貴博, 佐藤航, 中村真衣, 高嶋沙緒里

日本病理学会会誌 112 ( 1 ) 362 - 362 2023.3

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口腔扁平上皮癌におけるladinin-1と細胞極性・上皮性格制御

阿部達也, 山崎学, 丸山智, Chan Nyein Nyein, 田沼順一

日本病理学会会誌 112 ( 1 ) 289 - 289 2023.3

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唾液腺多形腺腫由来細胞は低酸素環境下にてCD73による増殖及び遊走能を亢進する

丸山智, 山崎学, 阿部達也, Chan Nyein Nyein, 田沼順一

日本病理学会会誌 112 ( 1 ) 292 - 292 2023.3

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頭頸部癌特異的スプライシングイベントの探索

阿部達也, 山崎学, 丸山智, Chan Nyein Nyein, 田沼順一

日本病理学会会誌 112 ( 1 ) 291 - 291 2023.3

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当科における口腔白板症患者の臨床的検討

船山昭典, 新美奏恵, 羽賀健太, 齋藤大輔, 佐久間英伸, 野澤舞, 勝良剛詞, 林孝文, 阿部達也, 田沼順一, 芳澤享子, 小林正治

日本口腔診断学会雑誌 36 ( 1 ) 93 - 93 2023.2

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当科における口腔白板症患者の臨床的検討

船山昭典, 新美奏恵, 羽賀健太, 齋藤大輔, 佐久間英伸, 野澤舞, 勝良剛詞, 林孝文, 阿部達也, 田沼順一, 芳澤享子, 小林正治

日本口腔診断学会雑誌 36 ( 1 ) 93 - 93 2023.2

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A case of tongue cancer in a youth treated with nivolumab for neck recurrence

木口哲郎, 隅田賢正, 阿部達也, 林孝文, 田沼順一, 冨原圭

日本口腔腫瘍学会総会・学術大会プログラム・抄録集 41st 2023

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天疱瘡2例のLBC法における細胞像の検討

丸山智, 山崎学, 阿部達也, 田沼順一

新潟県臨床細胞学会会報 ( 37 ) 54 - 54 2022.12

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コレステロールは口腔扁平上皮癌細胞の極性を制御し遊走を促進する(Cholesterol assists migration of oral squamous cell carcinoma by regulating front-rear cell polarity)

チャン・ニェインニェイン, 山崎学, 丸山智, 阿部達也, 河原田壮史, 小林正治, 田沼順一

日本病理学会会誌 111 ( 1 ) 278 - 278 2022.3

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口腔細胞診の従来法とLBC法において判定精度に影響を与える臨床病理学的因子の検討

河原田壮史, 河原田壮史, 丸山智, 山崎学, 阿部達也, 上野山敦士, 秋森俊行, 秋森俊行, 小島拓, 小島拓, 冨原圭, 小林正治, 田沼順一

日本口腔診断学会総会プログラム・抄録集 35th 2022

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口腔がん早期診断用マーカーの同定に向けた新規発がんモデルの作製

河原田壮史, 山崎学, 丸山智, 阿部達也, 北野太一, Chan Nyein Nyein, 小林正治, 田沼順一

新潟歯学会雑誌 51 ( 2 ) 124 - 124 2021.12

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口腔領域に発症したOI-LPD4例の臨床病理学的検討と最近15年間の文献的考察

河原田壮史, 丸山智, 山崎学, 阿部達也, 黒川亮, 片桐渉, 林孝文, 高木律男, 小林正治, 田沼順一

新潟歯学会雑誌 51 ( 2 ) 114 - 115 2021.12

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口腔領域に発症したOI-LPDの臨床病理学的解析

河原田壮史, 丸山智, 山崎学, 阿部達也, 黒川亮, 片桐渉, 林孝文, 高木律男, 小林正治, 田沼順一

日本口腔科学会雑誌 70 ( 2 ) 147 - 147 2021.7

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肺腺癌におけるリボソームRNA遺伝子プロモーター領域の遺伝子変異

大橋瑠子, 梅津哉, 近藤修平, 阿部達也, 田沼順一, 本山悌一, 味岡洋一

日本病理学会会誌 110 ( 1 ) 251 - 251 2021.3

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口底部に発生した孤立性神経線維腫の1例

野澤舞, 三上俊彦, 船山昭典, 齋藤大輔, 須田大亮, 新美奏恵, 阿部達也, 田沼順一, 新國農, 西山秀昌, 林孝文, 小林正治

日本口腔診断学会雑誌 34 ( 1 ) 73 - 74 2021.2

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口底部に発生した孤立性神経線維腫の1例

野澤舞, 三上俊彦, 船山昭典, 齋藤大輔, 須田大亮, 新美奏恵, 阿部達也, 田沼順一, 新國農, 西山秀昌, 林孝文, 小林正治

日本口腔内科学会雑誌 26 ( 2 ) 121 - 122 2020.12

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Serrated neoplasia pathwayにおけるSOX2発現の検討

高村佳緒里, 味岡洋一, 阿部達也, 大橋瑠子, 谷優佑, 近藤修平, 田口貴博, 佐藤航, グリツン・タチアナ, 西川直人

日本病理学会会誌 109 ( 1 ) 326 - 326 2020.3

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がん細胞による死細胞貪食は細胞遊走とDKK1発現を促進する

山崎学, 丸山智, 阿部達也, 朔敬, 田沼順一

日本病理学会会誌 109 ( 1 ) 396 - 396 2020.3

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術前化学放射線療法を施行した痔瘻癌の1例

中野麻恵, 島田能史, 平井裕美子, 松本瑛生, 阿部馨, 田中花菜, 小柳英人, 中野雅人, 廣瀬雄己, 加納陽介, 三浦宏平, 市川寛, 滝沢一泰, 羽入隆晃, 永橋昌幸, 坂田純, 阿部達也, 小林隆, 小杉伸一, 若井俊文

日本消化器病学会甲信越支部例会抄録集 67th 2020

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下顎骨に発生した象牙質形成性幻影細胞腫の1例 Reviewed

船山昭典, 三上俊彦, 新美奏恵, 片桐渉, 金丸祥平, 西山秀昌, 林孝文, 阿部達也, 山崎学, 小林正治

日本口腔科学会雑誌 68 ( 2 ) 188 - 188 2019.7

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当院における小腸カルチノイド7例の臨床的検討

冨永顕太郎, 川田雄三, 本田穣, 上村顕也, 横山純二, 寺井崇二, 田島陽介, 中野雅人, 島田能史, 亀山仁史, 若井俊文, アネコフ・アレクセイ, 味岡洋一, 阿部達也, 梅津哉, 岩渕三哉

日本大腸肛門病学会雑誌 72 ( 5 ) 348 - 348 2019.5

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多臓器転移と肺癌性リンパ管症を来した6mm大の胃原発小絨毛癌の1剖検例

谷優佑, 味岡洋一, 大橋瑠子, 加藤卓, 高村佳緒里, 杉野英明, 阿部達也, 近藤修平, 田口貴博, 佐藤航

日本病理学会会誌 108 ( 1 ) 367 - 367 2019.4

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多臓器転移と肺癌性リンパ管症を来した6mm大の胃原発小絨毛癌の1剖検例

谷優佑, 味岡洋一, 大橋瑠子, 加藤卓, 高村佳緒里, 杉野英明, 阿部達也, 近藤修平, 田口貴博, 佐藤航

日本病理学会会誌 108 ( 1 ) 367 - 367 2019.4

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LADININ-1 IS INVOLVED IN CELL MOTILITY AND PROLIFERATION OF ORAL SQUAMOUS CELL CARCINOMA CELLS (proceeding)

Tatsuya Abe, Manabu Yamazaki, Satoshi Maruyama, Yoichi Ajioka

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 128 ( 1 ) e81 - e82 2019

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Ladinin-1 regulating proliferation and migration of oral squamous cell carcinoma via actin molecules

Tatsuya Abe, Yoichi Ajioka, Manabu Yamazaki, Satoshi Maruyama

108 ( 1 ) 323 - 323 2019

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マイクロスコープを用いた再歯根尖切除術の1例

大倉直人, 山本信一, 阿部達也, 竹内亮祐, 遠間愛子, 枝並直樹, 吉羽永子, 吉羽邦彦, 野杁由一郎

新潟歯学会雑誌 48 ( 1 ) 29 - 35 2018.6

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マイクロスコープを用いた再歯根尖切除術の1例

大倉直人, 山本信一, 阿部達也, 竹内亮祐, 遠間愛子, 枝並直樹, 吉羽永子, 吉羽邦彦, 野杁由一郎

新潟歯学会雑誌 48 ( 1 ) 29 - 35 2018.6

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口腔扁平上皮癌における死細胞誘導性細胞増殖機構の解明

山崎学, 丸山智, 阿部達也, 田沼順一

日本病理学会会誌 107 ( 1 ) 346 - 346 2018.4

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口腔扁平上皮癌細胞におけるladinin-1の機能解析

阿部達也, 丸山智, 山崎学, 味岡洋一

日本病理学会会誌 107 ( 1 ) 458 - 458 2018.4

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口腔粘膜悪性境界病変におけるp53免疫組織化学的検索の取り組み

丸山智, 山崎学, 阿部達也, 田沼順一

日本病理学会会誌 107 ( 1 ) 459 - 459 2018.4

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口腔粘膜悪性境界病変におけるp53免疫組織化学的検索の取り組み

丸山智, 山崎学, 阿部達也, 田沼順一

日本病理学会会誌 107 ( 1 ) 459 - 459 2018.4

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口腔扁平上皮癌における死細胞誘導性細胞増殖機構の解明

山崎学, 丸山智, 阿部達也, 田沼順一

日本病理学会会誌 107 ( 1 ) 346 - 346 2018.4

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Ladinin-1 regulates proliferation and migration of oral squamous cell carcinoma cells via mediation of actin dynamics

Abe Tatsuya, Yamazaki Manabu, Maruyama Satoshi, Ajioka Yoichi

86 - 86 2018

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口腔扁平上皮癌におけるSOX 9細胞質発現は予後不良と関連する

隅田賢正, 山崎学, 阿部達也, 高木律男, 丸山智

新潟歯学会雑誌 47 ( 2 ) 120 - 121 2017.12

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感染性リンパ節腫脹との鑑別に苦慮した悪性リンパ腫の1例

三上俊彦, 原太一, 加藤祐介, 船山昭典, 金丸祥平, 小田陽平, 新美奏恵, 阿部達也, 丸山智, 西山秀昌, 林孝文, 小林正治

日本口腔科学会雑誌 66 ( 2 ) 182 - 182 2017.7

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口腔癌治療後に生じたbizarre stromal reactionの2例

山崎学, 隅田賢正, 丸山智, 阿部達也, 程くん, 朔敬

日本病理学会会誌 106 ( 1 ) 424 - 424 2017.3

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低酸素環境下でMYCは唾液腺多形性腺腫由来細胞の生存・増殖を亢進する

丸山智, 山崎学, 阿部達也, 隅田賢正, 程クン, 朔敬

日本病理学会会誌 106 ( 1 ) 295 - 295 2017.3

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口腔表在性癌と非癌部粘膜上皮との界面におけるタンパク質動態解析

阿部達也, 丸山智, 山崎学, 許波, 隅田賢正, 程クン, 山本格, 朔敬

日本病理学会会誌 106 ( 1 ) 408 - 408 2017.3

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口腔扁平上皮癌におけるSOX9の発現様式

隅田賢正, 丸山智, 山崎学, 阿部達也, 高木律男, 程クン

日本病理学会会誌 106 ( 1 ) 364 - 364 2017.3

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Le Fort I型骨切り術後に生じた正中上顎骨嚢胞の1例

大貫尚志, 阿部達也, 児玉泰光, 勝見祐二, 西川敦, 黒川亮, 木口哲郎, 程くん, 林孝文, 高木律男

日本口腔科学会雑誌 65 ( 2 ) 152 - 152 2016.7

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唾液腺多形性腺腫細胞は低酸素環境下でHIF-1α-MYC相互作用によってエネルギー代謝を制御している

丸山智, 山崎学, 阿部達也, バブカイール・ハムザ, 隅田賢正, 程君, 朔敬

日本病理学会会誌 105 ( 1 ) 468 - 468 2016.4

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口腔粘膜乳頭腫は粘液腺導管開口部に発生する

朔敬, 丸山智, 山崎学, 阿部達也, バブカイール・ハムザ, 隅田賢正, 程君

日本病理学会会誌 105 ( 1 ) 419 - 419 2016.4

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発生学的組織病理形成ではなく炎症により生じた口腔内リンパ管上皮嚢胞(Inflammatory but not developmental histopathogenesis of intraoral lymphoepithelial cyst)

山崎学, 丸山智, 阿部達也, バブカイール・ハムザ, 隅田賢正, 程君, 朔敬

日本病理学会会誌 105 ( 1 ) 424 - 424 2016.4

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口腔表在性癌と非癌部粘膜上皮との界面における細胞競合現象の解析

阿部達也, 丸山智, 山崎学, 許波, Babkair Hamzah, 隅田賢正, 程君, 山本格, 朔敬

日本病理学会会誌 105 ( 1 ) 421 - 421 2016.4

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口腔表在性癌と非癌部粘膜上皮との界面における細胞競合現象

阿部達也, 丸山智, 山崎学, Babkair Hamzah, 隅田賢正, 程くん, 朔敬

新潟歯学会雑誌 45 ( 2 ) 105 - 106 2015.12

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口腔扁平上皮癌における皮膚型角化の分化誘導と細胞増殖の調整機構

阿部達也, 丸山智, 山崎学, Babkair Hamzah, 隅田賢正, 程くん, 朔敬

新潟歯学会雑誌 45 ( 2 ) 103 - 103 2015.12

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角化嚢胞性歯原性腫瘍の組織学的バリエーションの検討炎症性修飾を中心に

山崎学, 丸山智, 阿部達也, 程くん, 酒井剛, 朔敬

日本病理学会会誌 104 ( 1 ) 469 - 469 2015.3

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口腔扁平上皮癌および正角化型異型上皮における正角化関連分子の動態

阿部達也, 丸山智, 山崎学, バブカイル・ハムザ, 程くん, 朔敬

日本病理学会会誌 104 ( 1 ) 467 - 467 2015.3

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低酸素応答性ファイブロネクチン生合成が唾液腺多形性腺腫由来SM-AP細胞の増殖を促進する

丸山智, 山崎学, 阿部達也, バブカイル・ハムザ, 程くん, 朔敬

日本病理学会会誌 104 ( 1 ) 449 - 449 2015.3

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角化嚢胞性歯原性腫瘍は咀嚼筋内にも発生する角化性嚢胞の免疫組織化学的鑑別法

阿部達也, 丸山智, 山崎学, ハムザ・バブカイル, 三上俊彦, 新垣晋, 小林正治, 林孝文, 程クン, 朔敬

日本口腔科学会雑誌 63 ( 4 ) 414 - 415 2014.9

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口腔扁平上皮癌においてMFG-E8は同種死細胞処理だけでなく腫瘍進展にも関与している

山崎学, 程クン, 丸山智, 阿部達也, 朔敬

日本口腔科学会雑誌 63 ( 4 ) 387 - 387 2014.9

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腺様嚢胞癌細胞の転移 KGFシグナルによる細胞増殖性と遊走性の相反的制御機構

丸山智, 山崎学, 阿部達也, 程クン, 朔敬

日本口腔科学会雑誌 63 ( 4 ) 435 - 436 2014.9

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唾液腺腫瘍の新規筋上皮細胞マーカとしてのコネキシン43とpodoplanin(Connexin 43 and podoplanin as novel myoepithelial cell markers in salivary gland tumors)

Ahmed Essa, 常木雅之, 山崎学, 丸山智, 阿部達也, Hamzah Babkair, 程くん, 朔敬

日本病理学会会誌 103 ( 1 ) 273 - 273 2014.3

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口腔扁平上皮癌における接着結合分子のclaudin 1とzonula occludens 1(Tight junction molecules, claudin 1 and zonula occludens 1, in oral squamous cell carcinoma)

Hamzah Babkair, 山崎学, 阿部達也, Ahmed Essa, 丸山智, 程くん, 朔敬

日本病理学会会誌 103 ( 1 ) 281 - 281 2014.3

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口腔異型上皮-扁平上皮癌シーケンスにおける正角化関連分子の発現動態

阿部達也, 丸山智, Ahmed Essa, Hamzah Babkair, 山崎学, 程くん, 朔敬

日本病理学会会誌 103 ( 1 ) 281 - 281 2014.3

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唾液腺多形性腺腫由来SM-AP細胞の増殖は低酸素応答性パールカン生合成に依存している

丸山智, 山崎学, 阿部達也, Babkair Hamzah, 程くん, 朔敬

日本病理学会会誌 103 ( 1 ) 296 - 296 2014.3

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口腔扁平上皮癌細胞におけるMFG-E8発現の意義過剰発現細胞系による解析

山崎学, 程くん, 丸山智, 阿部達也, 朔敬

日本病理学会会誌 103 ( 1 ) 295 - 295 2014.3

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腫瘍を疑わせた顎関節炎の1例

安島久雄, 池田順行, 嵐山貴徳, 齋藤太郎, 荒井良明, 河村篤志, 西山秀昌, 阿部達也, 朔敬, 高木律男

日本顎関節学会雑誌 25 ( Suppl. ) 79 - 79 2013.7

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J-GLOBAL

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下顎窩骨吸収を主徴とした顎関節滑膜性軟骨腫症の1例初期病像の認識

加藤祐介, 小林正治, 三上俊彦, 西山秀昌, 阿部達也, 林孝文, 朔敬, 齊藤力

日本顎関節学会雑誌 25 ( Suppl. ) 78 - 78 2013.7

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口腔扁平上皮癌の側方進展界面における細胞死

阿部達也, 丸山智, Ahmed Essa, Hamzah Babkair, 山崎学, 程くん, 朔敬

日本病理学会会誌 102 ( 1 ) 319 - 319 2013.4

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口腔扁平上皮癌における間質性マクロファージ(Stromal macrophages in oral squamous cell carcinoma)

Ahmed Essa, 山崎学, 丸山智, 阿部達也, Hamzah Babkair, 程くん, 朔敬

日本病理学会会誌 102 ( 1 ) 361 - 361 2013.4

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唾液腺多形性腺腫細胞における低酸素応答性の細胞外基質合成

丸山智, 山崎学, 阿部達也, 程くん, 朔敬

日本病理学会会誌 102 ( 1 ) 364 - 364 2013.4

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MFG-E8は口腔扁平上皮癌の進展と死細胞貪食を促進する

山崎学, 程くん, 丸山智, 阿部達也, 朔敬

日本病理学会会誌 102 ( 1 ) 360 - 360 2013.4

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東京大学医学部附属病院顎口腔外科における歯原性腫瘍の統計的観察

阿部達也, 安部貴大, 古賀陽子, 阿部雅修, 末永英之, 菅野勇樹, 杉山円, 瀬戸一郎, 星和人, 西條英人, 森良之, 高戸毅

日本口腔科学会雑誌 62 ( 1 ) 65 - 65 2013.1

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口腔扁平上皮癌・上皮内癌の側方進展界面の病理組織学的解析(Histopathological varieties of lateral invasion fronts in oral squamous cell carcinoma and carcinoma in-situ)

阿部達也, 丸山智, 山崎学, アーメッド・イーサー, 程ジュン, 朔敬

日本癌学会総会記事 71回 144 - 145 2012.8

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口腔扁平上皮癌の浸潤を契機とした細胞外基質産生の実質細胞から間質細胞へのスイッチング機構(Parenchymal-stromal switching for extracellular matrix production before/after invasion of oral squamous cell carcinoma)

丸山智, 山崎学, 阿部達也, 程ジュン, 朔敬

日本癌学会総会記事 71回 144 - 144 2012.8

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脈管分布様式からみたワルチン腫瘍のリンパ性間質

阿部達也, 程くん, 丸山智, 朔敬

日本病理学会会誌 98 ( 1 ) 398 - 398 2009.3

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Presentations

Information Sciences and Oral Pathology Invited

Tatsuya Abé

The 35th Annual Meeting of the Japanese Society of Oral Pathology 2024.8

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Event date： 2024.7 - 2024.8

Language：Japanese Presentation type：Symposium, workshop panel (nominated)

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Artificial Intelligence and Computer Science in Pathology: Appllication to Oral Pathology Invited

Tatsuya Abé

2026.4

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臓器別病理診断講習会2「口腔粘膜病変の病理診断」 Invited

阿部達也

第114回日本病理学会総会 2025.4

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Research Projects

Morphological analysis of mRNA alternative splicing signature-specific histological findings in head and neck squamous cell carcinoma International coauthorship

2025.6 - 2025.11

System name：Scientific Exchanges

Awarding organization：Swiss National Science Foundation (SNSF)

Tatsuya Abé, Maxime Lafarge, Viktor Kölzer

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Authorship：Coinvestigator(s)

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レディオミクス導入による口腔癌頸部リンパ節節外浸潤(ENE)画像検出システムの開発

Grant number：25K13204

2025.4 - 2028.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

新国農, 西山秀昌, 阿部達也, 林孝文

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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頭頸部癌mRNA選択的スプライシングの病理学的意義に関する国際共同研究

Grant number：24KK0283

2025 - 2027

System name：科学研究費助成事業

Research category：国際共同研究加速基金(国際共同研究強化)

Awarding organization：日本学術振興会

阿部達也

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Authorship：Principal investigator

Grant amount：\15600000 （ Direct Cost: \12000000 、 Indirect Cost：\3600000 ）

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Immune escape mechanisms induced by dead cell-derived ectopic nucleic acids in oral cancer

Grant number：24K13126

2024.4 - 2027.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

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Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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口腔・頭頸部扁平上皮癌におけるRNA選択的スプライシングの病理学的意義の解明

Grant number：24K12895

2024.4 - 2027.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

阿部達也

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Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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Role of the CD73-CXCL10 signaling pathway in tumor self-regulating mechanisms in the extracellular matrix

Grant number：24K13110

2024.4 - 2027.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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Exploring novel molecular subtypes and therapeutic targets based on the molecular signatures in papillary renal cell carcinoma

Grant number：24K10139

2024.4 - 2027.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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Elucidation of the molecular mechanisms in the microenvironment of oral cancer using single-cell RNA sequence analysis

Grant number：23K09150

2023.4 - 2026.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

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Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

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口腔扁平上皮癌の間質浸潤と側方上皮内進展：その相反的制御と分子基盤

Grant number：21K09841

2021.4 - 2024.3

System name：科学研究費助成事業基盤研究(C)

Research category：基盤研究(C)

Awarding organization：日本学術振興会

阿部達也

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

これまでに, 口腔扁平上皮癌の癌-非癌界面における蛋白質網羅的解析により, 癌界面部組織に特異的に増加した蛋白質である ladinin-1 (LAD1) が癌細胞の平面遊走と垂直遊走に相反的な制御を行っている可能性が見出されていることに加え, 免疫蛍光染色を用いた解析から, LAD1 抑制細胞における細胞形態変化と, vimentin 陽性細胞の有意な増加, E-cadherin の細胞膜上からの有意な減少および細胞質内陽性像の有意な増加を認めたことから, 上皮間葉転換 (EMT) 様表現型の表出に関わっている可能性が考えられていた.
また, EMT 関連遺伝子の発現変動を LAD1 発現抑制下で検討すると, LAD1 発現を抑制した口腔扁平上皮癌培養細胞株 HSC-2 および HSC-4 で, WNT5A 遺伝子の有意な発現増加が認められたことから, WNT pathway のなかでも, 特に EMT と細胞平面極性への関連が知られる膜貫通タンパクである ROR2 の関連性を検討した. LAD1 の発現抑制下での ROR2 遺伝子発現は, 特に HSC-4 で WNT5A 発現と連動性がみられたことから, LAD1 の発現変動に伴う細胞遊走極性と, EMT 様表現型の発現に, ROR2 の関連性が示唆され, 現在, 同じく siRNA 法での ROR2 発現抑制下での LAD1 および EMT に関連した vimentin・E-cadherin の発現変動, また LAD1・ROR2 の共発現抑制の系を検討中である.

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死細胞貪食による口腔がん細胞活性化：脂質クオリティが果たす役割を探る

Grant number：21K09856

2021.4 - 2024.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

山崎学, 阿部達也, 丸山智, 冨原圭, 泉健次, 田沼順一

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

がん細胞は正常細胞とは異なる脂質代謝を有し、近年、がんにおける脂質クオリティ（脂質組成）の重要性が明らかになりつつある。本研究課題では、「死細胞貪食を起点としたがん細胞活性化の機序に、死細胞由来脂質によってもたらされる脂質クオリティ変化が関与する」という仮説のもと、(1)がん細胞のおける死細胞由来脂質の局在変化を追跡し、(2)貪食後に生じるがん細胞の脂質クオリティを解析することで、(3)細胞増殖・遊走・浸潤能に関わる分子機構との接点を明らかにすることを目的としている。今年度は、以下の疑問を解決すべく検討をおこなった。
1) ネクローシス細胞は生活がん細胞に貪食されるのか？: 口腔扁平上皮癌由来培養細胞株を脂質親和性色素PKH26にて標識後、凍結融解によって誘導したネクローシス細胞を、同種の生活がん細胞と共培養した。共焦点レーザー顕微鏡解析の結果、PKH26陽性を示す死細胞断片は生活がん細胞の細胞質内に認められた。これより、ネクローシス細胞は生活がん細胞によって貪食されることが示された。
2) 細胞内コレステロール変化は細胞機能を変化させるのか？: これまでの検討により、ネクローシス細胞と共培養した際、生活がん細胞内にコレステロールが蓄積される可能性が推測された。そこでまず、細胞内コレステロールレベル変化による細胞の機能変化を検索した。コレステロール-MCD複合体の添加により、細胞内コレステロールを上昇させると、細胞形態は多辺形から扇状へと変化し、細胞遊走能が亢進することが示された。

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細胞外基質環境下における腫瘍特異的なCD73誘導低酸素応答性増殖機構の解明

Grant number：21K10109

2021.4 - 2024.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

丸山智, 阿部達也, 山崎学, 田沼順一

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

1) CD73発現抑制によるECMの発現動態の検証: 低酸素環境下におけるCD73発現とECM合成能との関係を解析するために、siRNA法によるCD73発現抑制下でのECM分子である、perlecanやfibronectinの発現を検討したところ、SM-AP1/4ともに発現抑制はみられなかった。よってCD73発現はECM合成能に影響を及ぼしていない可能性が示唆された。
 
2) 細胞増殖関連液性因子の網羅的解析: SM-AP細胞を低酸素培養条件下と通常培養条件下及びsiRNA法によるCD73発現抑制下で培養した後、各培養上清を回収し、Proteome ProfilerTM 抗体アレイキット(R&D systems)を用いて細胞増殖関連液性因子の網羅的解析を行った。その結果、IP-10やAngiogeninなどCD73発現抑制下で同様に発現が抑制されるいくつかの候補分子を見出した。さらにこれまでの研究で、これらの候補分子は低酸素培養条件（1％O２/5％CO２/94％N２）及び通常培養条件下でのSM-AP細胞系における各培養上清において発現が亢進していることもわかっており、低酸素下において、HIF-1αを介したCD73発現上昇との関連も確認されている。
 
3) CD73発現動態におけるSTAT3の影響についての検討: 昨年度に続いて、siRNA法によるCD73及びHIF-1α発現抑制下でのSTAT3の発現を比較してみると、SM-AP1/4ともにCD73抑制下では、STAT3の発現抑制傾向が見られたものの、HIF-1α発現抑制下ではSTAT3の発現抑制はみられなかった。以上の結果からは、低酸素下において、HIF-1αを介さない別の経路でSTAT3の発現上昇をきたしている可能性が示唆された。

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Cell competition at the lateral invasion front of oral squamous cell carcinoma

Grant number：19K10101

2019.4 - 2022.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

Saku Takashi

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Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

Based on our histopathological recognition of cell death occurring at the invasion front of oral squamous cell carcinoma cells against non-cancerous epithelial cells, we formulated a hypothesis that those dead cells are resulted from cell competition between them. We investigated the significance and cell machinery of cell death at the invasion interface using morphofunctional analyses, and showed that oral squamous cell carcinoma cells were activated by their own autophagacytosis of neighboring apoptotic carcinoma cells via a Rac1-dependent manner and that LAD1 functioned in filopodia/lamellipodia formation of carcinoma cells to form actin arc with actin filaments towards the lateral direction of invasion. In addition, we found that hyaline bodies arising at the invasion interface resembled Civatte bodies of oral lichen planus in terms of shape and possible generation route through dyskeratosis. Dyskeratotic features were shown to be useful in cytological diagnosis of oral malignancy.

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Molecular regulation of actin polymerization and arrangement in the lateral front between oral squamous cell carcinoma and non-cancerous epithelium

Grant number：18K09550

2018.4 - 2021.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

Abe Tatsuya

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

We have reported that ladinin-1 (LAD1) was highly expressed in cancer tissues adjacent to non-cancerous tissues by proteomic analysis of histopathological specimens of oral squamous cell carcinoma (OSCC). In a present study, we investigated the role of LAD1 in cancer development. LAD1-knockdown OSCC cells by siRNA method showed decreased cell proliferation, decreased planar cell migration, and enhanced three-dimensional cell migration. LAD1 localized to actin fibers in intracellular actin arcs, and inhibition of LAD1 expression resulted in decreased expansion of lamella and loss of epithelial-like cell morphology. These results suggested that LAD1 involved in cell migration through regulation of actin molecule and related to the expression of epithelial morphology and properties.

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Proteomic analysis of cell competition in the lateral invasion front of oral squamous cell carcinoma

Grant number：15K20384

2015.4 - 2018.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Research category：Grant-in-Aid for Young Scientists (B)

Awarding organization：Japan Society for the Promotion of Science

ABE Tatsuya

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Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

Oral squamous cell carcinoma (SCC) and carcinoma in-situ (CIS) frequently form the interface facing non-cancerous epithelium. I hypothesized cell competition might be occurred between cancer and non-cancerous cells in this interface. Thus, I investigated this interface histopathologically and performed proteomic analysis using LC-MS/MS. In histological analysis, apoptotic bodies, hyaline bodies, and other morphological changes suggesting cell damage were frequently observed in the cancer side adjacent to the interface. From proteomic analysis, 7 proteins, specifically increasing or decreasing in the cancer or non-cancerous sides adjacent to the interface, were identified. These proteins may be involved in cell competition between oral SCC/CIS cells and non-cancerous cells.

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Hypoxia-responsive MYC promotes the survival and growth of pleomorphic adenoma cells in hypoxic conditions.

Grant number：15K11069

2015.4 - 2018.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

Maruyama Satoshi

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Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

On the basis of hypovasucularity of the salivary pleomorphic adenoma, we had a hypothesis that pleomorphic adenoma cells are able to survive in hypoxic conditions. To understand the hypoxia-dependent manner of energy metabolism in this particular tumor, we analyzed function of MYC, which are the most important factor of metabolic regulation, in cell proliferation and migration in hypoxic-conditioned pleomorphic adenoma cells. In hypoxic condition, SM-AP cells, human pleomorphic adenoma cell systems, showed higher gene expression levels of HIF-1α and MYC in hypoxia. HIF-1α protein was also kept in higher levels and localized more significantly in nuclei. The proliferation and migration of SM-AP cells were reduced under the lack of MYC expression. These results indicated that hypoxic conditions induced pleomorphic adenoma cells to produce MYC, which was maintained by high HIF-1α protein levels.

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Phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: a possible driving force for cancer progression

Grant number：15K11006

2015.4 - 2018.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

Yamazaki Manabu

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Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

Apoptotic cancer cells are cleaned by macrophages and also by the neighboring cancer cells. Based on a hypothesis that apoptotic cell clearance by living carcinoma cells could contribute to cancer cell activities and tumor progression, we investigated a biological significance of this phenomenon using cultured cell lines derived from oral squamous cell carcinoma. When co-cultured with UV-induced apoptotic cells, the most of living cells engulfed apoptotic cells, and this engulfment was inhibited by Rac1 inhibitor. Electron microscopy demonstrated the engulfed cells localized within the phagosomes, with which the lysosomes seem to fuse. Furthermore, co-culture with apoptotic cells enhanced migration and invasion. These results suggested that self-clearance may upregulate cancer cell activities. Control of self-clearance in cancer would open up a new direction for therapeutic intervention.

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Molecular pathways and functional varieties of hemophagocytosis-induced keratinization in oral squamous cell carcinoma cells: from cell death to proliferation and invasion

Grant number：15K15693

2015.4 - 2017.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Research category：Grant-in-Aid for Challenging Exploratory Research

Awarding organization：Japan Society for the Promotion of Science

SAKU Takashi

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Grant amount：\3510000 （ Direct Cost: \2700000 、 Indirect Cost：\810000 ）

We have defined the keratinization of oral squamous cell carcinoma as skin-type orthokeratinization due to keratin 17 expression which never occurs in normal oral mucosa. Such an expression of dyskeratotic keratin 17 was shown to be induced by hemophagacytosis-derived hemoglobin released from erythrocytes and to mediate expressions of OH-1, PAR-2, 14-3-3σ, and YAP. These functional factors contributed to molecular pathways not only for cell death but for cellular proliferation and invasion in oral squamous cell carcinoma. In addition, cell death in oral lichen planus was explained by similar mechanisms starting from hemophagacytosis because hemorrhage often occurred along the epithelial interface, and keratinization-based cellular evaluation was confirmed to be useful in oral cytology to diagnose malignancy. This much functional varieties of phagocytosis-mediated keratinization were never expected, when we formulated our hypothesis that keratinization is initiated by hemophagocytosis.

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Pathogenesis of chewing-related oral cancer in Myanmar: a molecular pathoepidemiological study

Grant number：26305032

2014.4 - 2019.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Research category：Grant-in-Aid for Scientific Research (B)

Awarding organization：Japan Society for the Promotion of Science

Saku Takashi

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Grant amount：\15990000 （ Direct Cost: \12300000 、 Indirect Cost：\3690000 ）

Based on our international collection of oral cancer cases including precancerous lesions and our newly developed virtual microscopy network, we listed up new and important histopathological findings of oral carcinoma in-situ. Then, we explained the significance of those histopathological features by various experiments by using oral squamous cell carcinoma cells in culture. As a result, we were successful in proposing science-based diagnostic criteria of oral carcinoma in-situ. In Myanmar, we carried out cohort study series in areas where betel chewing habits were highly prevalent. Frequencies of oral cancer and mucosal lesions were more frequent among chewers, while control residents who took beta-carotene containing fruits and vegetables with their high beta-carotene blood levels had less mucosal troubles. The present micro-level and macro-level approaches have achieved valuable future prospects for more accurate diagnostic methodology and more efficient prevention for oral cancer.

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Molecular patho-epidemiological study on the etiological background for oral superficial carcinoma among Asian ethnic groups

Grant number：25305035

2013.4 - 2017.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Research category：Grant-in-Aid for Scientific Research (B)

Awarding organization：Japan Society for the Promotion of Science

CHENG Jun

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Grant amount：\18200000 （ Direct Cost: \14000000 、 Indirect Cost：\4200000 ）

To investigate the epidemiological and biological backgrounds for the occurrence of oral superficial carcinomas, which are recently increasing in number in Japan with an aging population, we collected those cases from several Asian countries as controls. We firstly established a science/evidence-based standard for histopathological diagnosis of oral superficial carcinomas, with which we eliminated diagnostic disparities among hospitals from those countries. As a result, we confirmed that our new diagnostic standard based on combined expressions of some particular molecules was useful for any cases whose ethnic and etiological backgrounds were obviously different from each other. Hence, we were successful in demonstrating the diagnostic standard certainly worked in any occasions. Among the expressions of the particular molecules, those of keratin 17 were shown by our cell machinery investigations to characterize dyskeratotic carcinoma cells, which mimicked epidermal orthokeratosis.

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Proteome analysis of invasion starter molecules in oral squamous cell carcinoma

Grant number：25462849

2013.4 - 2016.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

Cheng Jun, MARUYAMA Satoshi, YAMAZAKI Manabu, ABE Tatsuya, SAKU Takashi

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Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）

The molecular mechanism of invasion of oral squamous cell carcinoma still remains unknown. To understand what sort of crosstalk between cancer cells and surrounding non-cancerous epithelial cells or stromal cells, we performed proteome analyses of laser-capture microdissected samples obtained from the interfaces between cancer cell nests and their surrounding non-cancerous epithelium of the oral mucosa or stromal tissues, which were objectively visualized by the aid of immunohistochemistry. As a result, we have determined proteins which were specifically expressed at both cancer and non-cancer sides of the interface zone. They were immunohistochemically identified to be expressed more in cancer or non-cancer sides. Thus, these newly identified molecules are considered to function in regulating squamous cell carcinoma cells to start to invade. It is expected to understand the machinery of cancer invasion when these molecules are investigated more in detail.

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Cell competition in lateral invasion fronts of oral carcinoma in-situ

Grant number：25861768

2013.4 - 2015.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Research category：Grant-in-Aid for Young Scientists (B)

Awarding organization：Japan Society for the Promotion of Science

ABE Tatsuya

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Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

Histopathologically, oral carcinoma in-situ (CIS) foci are frequently confronted with non/less malignant lesions including epithelial dysplasia when they invade laterally within the epithelial compartment. In those interfaces, cell competition-like phenomena must occur between CIS cells and less malignant cells. Thus, I have investigated such lateral invasion fronts of oral CIS against normal/dysplasitic epithelia in the tissue section level. There were apoptotic bodies (60%) and eosinophilic hyaline bodies (36%) in SCC/CIS sides of the interfaces. In addition, LC/MS/MS proteomics analysis detected interferon-induced proteins in those interface-adjacent carcinoma cells. These findings suggested carcinoma cells might be losers in cell competition with less malignance cells as winners, and that these cell competitive conditions are induced by cytokines shed from both side cells.

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Survival of salivary pleomorphic adenoma cells under the hypoxia-responsive extracellular matrix biosynthesis

Grant number：24592829

2012.4 - 2015.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

MARUYAMA Satoshi, ABE Tatsuya, YAMAZAKI Manabu, CHENG Jun, SAKU Takashi

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Grant amount：\5330000 （ Direct Cost: \4100000 、 Indirect Cost：\1230000 ）

Salivary pleomorphic adenoma is histopathologically characterized by its colorful stroma with myxoid, chondroid, and hyaline appearances, which is realized by its enhanced biosynthesis of extracellular matrix (ECM) molecules as well as by poor vascularity. Thus, pleomorphic adenoma cells embedded in such stromata are supposed to be able to survive in hypoxic conditions. To understand the hypoxia-dependent manner of cellular proliferation in this particular tumor, we analyzed function of perlecan and fibronectin, which are the most abundant ECM molecules, in cell proliferation in hypoxic-conditioned pleomorphic adenoma cells. Hypoxic conditions induce pleomorphic adenoma cells to produce perlecan and fibronectin, which is maintained by high HIF-1α protein levels, which is further realized by perlecan and fibronectin-rich circumstance of the stroma. The results indicate that pleomorphic adenoma cells have to go round in hypoxic circles to survive.

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A molecular pathoepidemiological study on tobacco chewing-related oral cancer in Asian and African areas

Grant number：23406038

2011.4 - 2015.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Research category：Grant-in-Aid for Scientific Research (B)

Awarding organization：Japan Society for the Promotion of Science

SAKU, Takashi, CHENG Jun, MARUYAMA Satoshi, YAMAZAKI Manabu, ABE Tatsuya

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Grant amount：\14820000 （ Direct Cost: \11400000 、 Indirect Cost：\3420000 ）

Betel quid chewing has been regarded as one of the most representative causative factor of oral squamous cell carcinoma (SCC) in the south Asian area. Taking these chewing-related oral SCC samples, we investigated them in comparison with non-chewers’ SCC samples from many aspects. Epidemiologically, we have carried out a cohort study in Myanmar to analyze oral and nutritional conditions among chewers and non-chewers and confirmed that chewing habits affected the oral mucosa to generate malignant lesions. Oral submucous fibrosis was closely related to epithelial alterations leading to such precancerous lesions as epithelial dysplasia and carcinoma in-situ. Investigating those samples, we have found several specific subtypes of precancerous lesions, and their biological significances were demonstrated in vivo. Those research efforts have been applied to our diagnostic services, and they were shown to be useful in objective histopathological diagnosis of oral mucosal malignancies.

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Molecular mechanisms of ghost cell formation and calcification in calcifying cystic odontogenic tumor (CCOT) cell lines

Grant number：22592033

2010 - 2012

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

CHENG Jun, MARUYAMA Satoshi, YAMAZAKI Manabu, SAKU Takashi, ABE Tatsuya

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Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

Calcifying cystic odontogenic tumor (CCOT) is histopathologically characterized by the emergence of ghost cells. However, their histopathogenesis has been poorly understood. To understand the cellular mechanism towards ghost cell formation, we have successfully established of cell lines from a CCOT surgical specimen. Using these CCOT cells, we successfully demonstrated that ghost cells were generated due to intracellular deposits of extracellular matrix molecules including perlecan, and that their calcification was started in those matrices and completed by proteolysis of deposited matrices towards their denucleated forms.

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Teaching Experience

歯の形態学

2022
Institution name：新潟大学
基礎歯学ｺｰｽﾜｰｸ(口腔病理学ベーシックコースII)

2021
Institution name：新潟大学
口腔分子病理学演習IIA

2021
Institution name：新潟大学
基礎歯学ｺｰｽﾜｰｸ(口腔病理学ベーシックコースI)

2021
Institution name：新潟大学
口腔分子病理学演習IB

2021
Institution name：新潟大学
口腔分子病理学演習IA

2021
Institution name：新潟大学
口腔分子病理学演習IIB

2021
Institution name：新潟大学
臨床口腔病理学演習IB

2021
Institution name：新潟大学
臨床口腔病理学演習IA

2021
Institution name：新潟大学
臨床口腔病理学演習IIB

2021
Institution name：新潟大学
臨床口腔病理学演習IIA

2021
Institution name：新潟大学
病理学総論

2020
Institution name：新潟大学
口腔病理学

2020
Institution name：新潟大学

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