Updated on 2024/12/21

写真a

 
TANAKA Shingo
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Assistant Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
External link

Degree

  • 博士(理学) ( 2010.3   大阪大学 )

Research Interests

  • 前頭前野

  • 報酬予測

  • 視覚

  • 大脳皮質

  • 両眼視差

  • 包括脳ネットワーク

  • ニホンザル

  • 両眼立体視

  • サル

  • 意思決定

  • 視覚情報処理

  • 報酬

Research Areas

  • Life Science / Cognitive and brain science

  • Life Science / Basic brain sciences

  • Life Science / Neuroscience-general  / システム神経科学

Research History (researchmap)

  • Niigata University   Faculty of Medicine   Assistant Professor

    2018.2

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  • Tamagawa University   Brain Science Institute   Specially Appointed Assistant Professor

    2016.4 - 2018.1

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  • Tamagawa University

    2010.4 - 2016.3

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  • Osaka University   Graduate School of Frontier Biosciences

    2010.3

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Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine   Assistant Professor

    2018.2

Education

  • 大阪大学大学院   生命機能研究科

    2004.4 - 2010.3

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  • 大阪大学大学院   理学研究科   生物科学専攻

    2001.4 - 2004.3

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  • Osaka University   School of Science   生物学科

    1997.4 - 2001.3

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Professional Memberships

 

Papers

  • Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain Reviewed International journal

    Mineki Oguchi, Shingo Tanaka, Xiaochuan Pan, Takefumi Kikusui, Keiko Moriya-Ito, Shigeki Kato, Kazuto Kobayashi, Masamichi Sakagami

    Communications Biology   4 ( 1 )   1088 - 1088   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    <title>Abstract</title>The lateral prefrontal cortex (LPFC) has a strong monosynaptic connection with the caudate nucleus (CdN) of the striatum. Previous human MRI studies have suggested that this LPFC-CdN pathway plays an important role in inhibitory control and working memory. We aimed to validate the function of this pathway at a causal level by pathway-selective manipulation of neural activity in non-human primates. To this end, we trained macaque monkeys on a delayed oculomotor response task with reward asymmetry and expressed an inhibitory type of chemogenetic receptors selectively to LPFC neurons that project to the CdN. Ligand administration reduced the inhibitory control of impulsive behavior, as well as the task-related neuronal responses observed in the local field potentials from the LPFC and CdN. These results show that we successfully suppressed pathway-selective neural activity in the macaque brain, and the resulting behavioral changes suggest that the LPFC-CdN pathway is involved in inhibitory control.

    DOI: 10.1038/s42003-021-02623-y

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    Other Link: https://www.nature.com/articles/s42003-021-02623-y

  • The effect of effort on reward prediction error signals in midbrain dopamine neurons Reviewed

    Shingo Tanaka, Jessica E Taylor, Masamichi Sakagami

    Current Opinion in Behavioral Sciences   41   152 - 159   2021.10

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.cobeha.2021.07.004

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  • The cost of obtaining rewards enhances the reward prediction error signal of midbrain dopamine neurons Reviewed

    Shingo Tanaka, John P. O’Doherty, Masamichi Sakagami

    Nature Communications   10 ( 1 )   2019.12

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s41467-019-11334-2

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    Other Link: http://www.nature.com/articles/s41467-019-11334-2

  • Computation of Object Size in Visual Cortical Area V4 as a Neural Basis for Size Constancy Reviewed

    Shingo Tanaka, Ichiro Fujita

    JOURNAL OF NEUROSCIENCE   35 ( 34 )   12033 - 12046   2015.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:SOC NEUROSCIENCE  

    Even when we view an object from different distances, so that the size of its projection onto the retina varies, we perceive its size to be relatively unchanged. In this perceptual phenomenon known as size constancy, the brain uses both distance and retinal image size to estimate the size of an object. Given that binocular disparity, the small positional difference between the retinal images in the two eyes, is a powerful visual cue for distance, we examined how it affects neuronal tuning to retinal image size in visual cortical area V4 of macaque monkeys. Depending on the imposed binocular disparity of a circular patch embedded in random dot stereograms, most neurons adjusted their preferred size in a manner consistent with size constancy. They preferred larger retinal image sizes when stimuli were stereoscopically presented nearer and preferred smaller retinal image sizes when stimuli were presented farther away. This disparity-dependent shift of preferred image size was not affected by the vergence angle, a cue for the fixation distance, suggesting that different V4 neurons compute object size for different fixation distances rather than that individual neurons adjust the shift based on vergence. This interpretation was supported by a simple circuit model, which could simulate the shift of preferred image size without any information about the fixation distance. We suggest that a population of V4 neurons encodes the actual size of objects, rather than simply the size of their retinal images, and that these neurons thereby contribute to size constancy.

    DOI: 10.1523/JNEUROSCI.2665-14.2015

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  • Double Virus Vector Infection to the Prefrontal Network of the Macaque Brain Reviewed

    Mineki Oguchi, Miku Okajima, Shingo Tanaka, Masashi Koizumi, Takefumi Kikusui, Nobutsune Ichihara, Shigeki Kato, Kazuto Kobayashi, Masamichi Sakagami

    PLOS ONE   10 ( 7 )   e0132825   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PUBLIC LIBRARY SCIENCE  

    To precisely understand how higher cognitive functions are implemented in the prefrontal network of the brain, optogenetic and pharmacogenetic methods to manipulate the signal transmission of a specific neural pathway are required. The application of these methods, however, has been mostly restricted to animals other than the primate, which is the best animal model to investigate higher cognitive functions. In this study, we used a double viral vector infection method in the prefrontal network of the macaque brain. This enabled us to express specific constructs into specific neurons that constitute a target pathway without use of germline genetic manipulation. The double-infection technique utilizes two different virus vectors in two monosynaptically connected areas. One is a vector which can locally infect cell bodies of projection neurons (local vector) and the other can retrogradely infect from axon terminals of the same projection neurons (retrograde vector). The retrograde vector incorporates the sequence which encodes Cre recombinase and the local vector incorporates the "Cre-On" FLEX double-floxed sequence in which a reporter protein (mCherry) was encoded. mCherry thus came to be expressed only in doubly infected projection neurons with these vectors. We applied this method to two macaque monkeys and targeted two different pathways in the prefrontal network: The pathway from the lateral prefrontal cortex to the caudate nucleus and the pathway from the lateral prefrontal cortex to the frontal eye field. As a result, mCherry-positive cells were observed in the lateral prefrontal cortex in all of the four injected hemispheres, indicating that the double virus vector transfection is workable in the prefrontal network of the macaque brain.

    DOI: 10.1371/journal.pone.0132825

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  • Dissociable functions of reward inference in the lateral prefrontal cortex and the striatum Reviewed

    Shingo Tanaka, Xiaochuan Pan, Mineki Oguchi, Jessica E. Taylor, Masamichi Sakagami

    FRONTIERS IN PSYCHOLOGY   6 ( 995 )   2015.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:FRONTIERS RESEARCH FOUNDATION  

    In a complex and uncertain world, how do we select appropriate behavior? One possibility is that we choose actions that are highly reinforced by their probabilistic consequences (model-free processing). However, we may instead plan actions prior to their actual execution by predicting their consequences (model-based processing). It has been suggested that the brain contains multiple yet distinct systems involved in reward prediction. Several studies have tried to allocate model-free and model-based systems to the striatum and the lateral prefrontal cortex (LPFC), respectively. Although there is much support for this hypothesis, recent research has revealed discrepancies. To understand the nature of the reward prediction systems in the LPFC and the striatum, a series of single-unit recording experiments were conducted. LPFC neurons were found to infer the reward associated with the stimuli even when the monkeys had not yet learned the stimulus-reward (SR) associations directly. Striatal neurons seemed to predict the reward for each stimulus only after directly experiencing the SR contingency. However, the one exception was "Exclusive Or" situations in which striatal neurons could predict the reward without direct experience. Previous single-unit studies in monkeys have reported that neurons in the LPFC encode category information, and represent reward information specific to a group of stimuli. Here, as an extension of these, we review recent evidence that a group of LPFC neurons can predict reward specific to a category of visual stimuli defined by relevant behavioral responses. We suggest that the functional difference in reward prediction between the LPFC and the striatum is that while LPFC neurons can utilize abstract code, striatal neurons can code individual associations between stimuli and reward but cannot utilize abstract code.

    DOI: 10.3389/fpsyg.2015.00995

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  • Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation Reviewed

    N Nakamura, S Tanaka, Y Teko, K Mitsui, H Kanazawa

    JOURNAL OF BIOLOGICAL CHEMISTRY   280 ( 2 )   1561 - 1572   2005.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC  

    Four isoforms of the Na+/H+ exchanger (NHE6-NHE9) are distributed to intracellular compartments in human cells. They are localized to Golgi and post-Golgi endocytic compartments as follows: mid- to trans-Golgi, NHE8; trans-Golgi network, NHE7; early recycling endosomes, NHE6; and late recycling endosomes, NHE9. No significant localization of these NHEs was observed in lysosomes. The distribution of these NHEs is not discrete in the cells, and there is partial overlap with other isoforms, suggesting that the intracellular localization of the NHEs is established by the balance of transport in and out of the post-Golgi compartments as the dynamic membrane trafficking. The overexpression of NHE isoforms increased the luminal pH of the compartments in which the protein resided from the mildly acidic pH to the cytosolic pH, suggesting that their in vivo function is to regulate the pH and monovalent cation concentration in these organelles. We propose that the specific NHE isoforms contribute to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.

    DOI: 10.1074/jbc.M410041200

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  • A novel kinesin-like protein, KIF1B beta 3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells Reviewed

    M Matsushita, S Tanaka, N Nakamura, H Inoue, H Kanazawa

    TRAFFIC   5 ( 3 )   140 - 151   2004.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BLACKWELL MUNKSGAARD  

    The kinesin superfamily protein, KIF1Bbeta, a splice variant of KIF1B, is involved in the transport of synaptic vesicles in neuronal cells, and is also expressed in various non-neuronal tissues. To elucidate the functions of KIF1Bbeta in non-neuronal cells, we analyzed the intracellular localization of KIF1Bbeta and characterized its isoform expression profile. In COS-7 cells, KIF1B colocalized with lysosomal markers and expression of a mutant form of KIF1Bbeta, lacking the motor domain, impaired the intracellular distribution of lysosomes. A novel isoform of the kinesin-like protein, KIF1Bbeta3, was identified in rat and simian kidney. It lacks the 5th exon of the KIF1Bbeta-specific tail region. Overexpression of KIF1Bbeta3 induced the translocation of lysosomes to the cell periphery. However, overexpression of KIF1Bbeta3-Q98L, which harbors a pathogenic mutation associated with a familial neuropathy, Charcot-Marie-Tooth disease type 2 A, resulted in the abnormal perinuclear clustering of lysosomes. These results indicate that KIF1Bbeta3 is involved in the translocation of lysosomes from perinuclear regions to the cell periphery.

    DOI: 10.1111/j.1600-0854.2003.00165.x

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  • KIF1B beta 2, capable of interacting with CHP, is localized to synaptic vesicles Reviewed

    N Nakamura, Y Miyake, M Matsushita, S Tanaka, H Inoue, H Kanazawa

    JOURNAL OF BIOCHEMISTRY   132 ( 3 )   483 - 491   2002.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPANESE BIOCHEMICAL SOC  

    Kinesin family proteins are microtubule-dependent molecular motors involved in the intracellular motile process. Using a Ca2+-binding protein, CHP (calcineurin B homologous protein), as a bait for yeast two hybrid screening, we identified a novel kinesin-related protein, KIF1Bbeta2. KIF1Bbeta2 is a member of the KIF1 subfamily of kinesin-related proteins, and consists of an amino terminal KIF1B-type motor domain followed by a tail region highly similar to that of KIF1A. CHP binds to regions adjacent to the motor domains of KIF1Bbeta2 and KIF1B, but not to those of the other KIF1 family members, KIF1A and KIF1C. Immunostaining of neuronal cells showed that a significant portion of KIF1Bbeta2 is co-localized with synaptophysin, a marker protein for synaptic vesicles, but not with a mitochondria-staining dye. Subcellular fractionation analysis indicated the co-localization of KIF1Bbeta2 with synaptophysin. These results suggest that KIF1Bbeta2, a novel CHP-interacting molecular motor, mediates the transport of synaptic vesicles in neuronal cells.

    DOI: 10.1093/oxfordjournals.jbchem.a003246

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MISC

  • Neural Mechanisms of Transitive Inference : Aiming to Construct Computational Theory for General Purpose Information Processor

    32 ( 6 )   845 - 850   2017.11

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  • Cognitive Functions in the Prefrontal Association Cortex; Transitive Inference and the Lateral Prefrontal Cortex

    田中慎吾, 小口峰樹, 坂上雅道

    Brain and Nerve   68 ( 11 )   1263‐1270   2016.11

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    Language:Japanese  

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  • 脳の科学Up Date 大きさ恒常性の神経メカニズム

    田中慎吾

    脳21   19 ( 1 )   76 - 79   2016.1

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  • 【Decision Making-意思決定・行動選択の神経科学】 意思決定・行動選択の神経科学 前頭前野におけるカテゴリー形成

    小口 峰樹, 田中 慎吾, Pan Xiaochuan, 坂上 雅道

    Clinical Neuroscience   32 ( 1 )   62 - 66   2014.1

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    Language:Japanese   Publisher:(株)中外医学社  

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  • Cyclopean image size tuning in macaque area V4 is dependent on binocular disparity in a manner consistent with size constancy

    Shingo Tanaka, Ichiro Fujita

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   200 - 200   2009

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:SPRINGER TOKYO  

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  • Interactions between binocular disparity and size tuning in the macaque area V4

    TANAKA Shingo, FUJIJTA Ichiro

    IEICE technical report   107 ( 542 )   79 - 84   2008.3

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    Language:Japanese   Publisher:The Institute of Electronics, Information and Communication Engineers  

    The perceived size of an object remains relatively stable despite changes in the size of retinal images accompanying changes in distance from the observer. In this perceptual phenomenon (size constancy), the brain uses distance information for calibrating the perceived size. Binocular disparity provides a clue about distance. To examine interaction between binocular disparity and stimulus size information, we recorded neuronal responses in the macaque cortical are V4. Half of V4 cells showed significant interaction between the tunings for binocular disparity and size. This behavior of V4 cells was consistent with psychophysical performance of human observers. The results suggest that V4 cells contribute to size constancy.

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  • Disparity- and size-selective neurons in macaque area V4 as a neural basis for size constancy

    Shingo Tanaka, Ichiro Fujita

    NEUROSCIENCE RESEARCH   58   S55 - S55   2007

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ELSEVIER IRELAND LTD  

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  • KIF1B beta 3, a novel variant of kinesin-motor KIF1B, involved in the movement of lysosomes to the cell periphery in non-neuronal cells

    M Matsushita, S Tanaka, N Nakamura, H Inoue, H Kanazawa

    FASEB JOURNAL   18 ( 8 )   C124 - C124   2004.5

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:FEDERATION AMER SOC EXP BIOL  

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  • CHP結合タンパク質KIF1Bp204によるシナプス小胞の輸送

    田中 慎吾, 松下 昌史, 中村 徳弘, 井上 弘樹, 金澤 浩

    生化学   74 ( 11 )   1398 - 1398   2002.11

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    Language:Japanese   Publisher:(公社)日本生化学会  

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  • KIF1Bp204によるシナプス小胞の輸送及びカルシウム結合蛋白質CHPとの相互作用

    田中 慎吾, 松下 昌史, 中村 徳弘, 井上 弘樹, 金澤 浩

    生化学   74 ( 8 )   892 - 892   2002.8

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Presentations

  • The neural mechanisms of adaptive behavior selection using simulated others in the brain under multiple social contexts

    Shingo Tanaka, Zhao Jingkang, Tetsuya Matsuda, Keisuke Kawasaki, Atsuhiko Iijima, Isao Hasegawa

    The 46th Annual Meeting of the Japan Neuroscience Society  2023.8 

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    Event date: 2023.8

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  • The neural network for social decision-making dependent on a multi-context environment

    Jingkang Zhao, Shingo Tanaka, Tetsuya Matsuda, Keisuke Kawasaki, Atsuhiko Iijima, Isao Hsegawa

    FENS Forum 2022  2022.7 

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    Event date: 2022.7

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  • The neural basis of social decision based on evaluation of others'intentions and social contexts

    Jingkang ZHAO, Shingo Tanaka, Mengxuan Zhao, Tetsuya Matsuda, Keisuke Kawasaki, Atsuhiko Iijima, Isao Hasegawa

    The 44th Annual Meeting of the Japan Neuroscience Society  2021.7 

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    Event date: 2021.7

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  • Spatiotemporal distribution of the decision-related value information in the macaque prefrontal cortex during the value based decision making

    Tanaka S, Ito Y, kawasaki K, Hasegawa I, Suzuki T, Sakagami M

    The 6th CiNet Conference: Brain-Machine Interface – Medical Engineering based on Neuroscience –  2020.2 

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    Event date: 2020.2

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  • ニホンザル前頭前野皮質脳波を利用した、報酬選択における価値関連情報のデコーディングとその時空間分布の検証

    田中慎吾, 伊藤陽介, 川嵜圭祐, 長谷川功, 鈴木隆文, 坂上雅道

    第66回中部日本生理学会  2019.10 

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  • Decoding the decision-related information from the prefrontal ECoG signals during the value-based decision making International conference

    Tanaka S, Ito Y, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M

    2019.7 

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  • Elucidating the role of the macaque lateral prefrontal cortex for the value-based decision making using the decoded neurofeeback International conference

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Kawato M, Sakagami M

    Real-time functional imaging and neurofeedback conference 2017  2017.11 

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  • Spatial and temporal distribution of value-related and the visual information in the macaque lateral prefrontal cortex International conference

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Kawato M, Sakagami M

    Neuroscience 2017, the 47th annual meeting of the Society for Neuroscience  2017.11 

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  • Distribution of value related information in the multiple areas of the macaque prefrontal cortex International conference

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Kawato M, Sakagami M

    The 40th Annual Meeting of the Japan Neuroscience Society  2017.7 

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  • Modulation of value information coded in the lateral prefrontal cortex by the decoded neurofeedback with the electrocorticographic (ECoG) signals International conference

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M

    Neuroscience 2016, the 46th annual meeting of the Society for Neuroscience  2016.11 

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  • Decoding the value related information from the ECoG signal recorded from the multiple areas ofthe prefrontal cortex International conference

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M

    The 39th Annual Meeting of the Japan Neuroscience Society  2016.7 

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  • Decoding value related signals represented in multiple areas of the prefrontal cortex using ECoG electrodes International conference

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M

    The 31st International Congress of Psychology 2016  2016.7 

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    Language:English   Presentation type:Symposium, workshop panel (nominated)  

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  • Decoding the value related signal represented in the multiple areas of the prefrontal cortex using the ECoG electrodes International conference

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M

    International Symposium on Prediction and Decision Making  2015.10 

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  • The cost paid for the reward enhances the value of the reward International conference

    Tanaka S, O’Doherty JP, SakagamiM

    The 37th Annual Meeting of the Japan Neuroscience Society  2014.9 

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  • The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward

    Tanaka S, O’Doherty JP, SakagamiM

    第91回日本生理学会大会  2014.3 

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  • The enhancement of the reward value by the cost paid for the reward

    Tanaka S, O’Doherty JP, SakagamiM

    Symposium on Human Cognitive Neuroscience: Neural Dynamics of Internal Switching  2014.1 

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  • The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward International conference

    Tanaka S, O’Doherty JP, Sakagami M

    Neuroscience 2013, the 43rd annual meeting of the Society for Neuroscience  2013.11 

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  • The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward International conference

    Tanaka S, O’Doherty JP, SakagamiM

    International Symposium on Prediction and Decision Making  2013.10 

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  • The effect of cost on the reward prediction error signal in midbrain dopamine neurons International conference

    Tanaka S, O’Doherty JP, SakagamiM

    The 36th Annual Meeting of the Japan Neuroscience Society  2013.6 

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  • The effect of cost on the reward prediction error signal in midbrain dopamine neurons

    Tanaka S, O’Doherty JP, SakagamiM

    人間と動物の「意思決定・論理・認知」を探る --神経科学から哲学まで--  2013.2 

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  • The effect of the cost to the reward prediction error signal in the midbrain dopamine neuron

    Tanaka S, O’Doherty JP, SakagamiM

    「脳と心のメカニズム」第13回冬のワークショップ  2013.1 

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  • 両眼視差に依存したサル視覚野神経細胞の大きさ選択性の変化と大きさ恒常性との関係

    Shingo Tanaka, Ichiro Fujita

    第3回ブレイン・バイオコミュニケーション研究会  2009.11 

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  • Cyclopean image size tuning in macaque area V4 is dependent on binocular disparity in a manner consistent with size constancy. International conference

    Shingo Tanaka, Ichiro Fujita

    36th International Congress of Physiological Science  2009.7 

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  • Disparity dependent scaling of cyclopean image size tuning in macaque area V4 and its relation to size constancy. International conference

    Shingo Tanaka, Ichiro Fujita

    Neuroscience 2008, the 38th annual meeting of the Society for Neuroscience  2008.11 

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  • サルV4野神経細胞における両眼視差選択性と大きさ選択性の相互関係

    Shingo Tanaka, Ichiro Fujita

    ニューロコンピューティング研究会  2008.3 

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  • Disparity- and size-selective neurons in macaque area V4 as a neural basis for size constancy

    Shingo Tanaka, Ichiro Fujita

    The 30th Annual Meeting of the Japan Neuroscience Society  2007.9 

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Research Projects

  • Investigation and manipulation of neural networks for adaptive decision making in competitive and cooperative interactions

    Grant number:21K07258

    2021.4 - 2024.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • The neural basis of "outwitting others": behavioral selection based on simulating others in the brain

    Grant number:18K07349

    2018.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Tanaka Shingo

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Although multiple brain areas are involved in “the theory of mind”, the ability to infer the mind of others, the neural process of inferring others which changes with interaction with the self, and the neural basis of action selection according to the inferred others in the brain and the surrounding situation is still unknown. In this study, we developed an interactive experimental task and aimed to elucidate the neurophysiological basis of strategic behavioral selection using simulated others in the brain. First, we performed fMRI experiments to record the brain activity of human subjects. We used a computational behavioral model to explain the behavior of human subjects and explored the brain activity that correlated with the parameters of the model, and found activation in the TPJ and prefrontal cortex. In addition, we developed ECoG electrodes to record neural activity from macaque macaques and trained them to perform the interactive task.

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  • Revealing the mechanism of the value information generation in the prefrontal cortex using ECoG electrodes

    Grant number:16K16653

    2016.4 - 2018.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category:Grant-in-Aid for Young Scientists (B)

    Awarding organization:Japan Society for the Promotion of Science

    TANAKA Shingo

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    When deciding between multiple options, our brain estimates their values and choose the most desirable one. A lot of studies show that areas in the prefrontal cortex (PFC) play different but essential roles for value calculation and comparison. However, few studies directly examined how the value information is generated in the PFC. Here, I developed ECoG electrodes to implant in the wide-ranging areas of the macaque PFC and trained a monkey, who was implanted the ECoG electrodes on the PFC subareas, to perform the context dependent value learning task. I recorded the ECoG signal while the monkey performed the task and tried to decode the reward value from the ECoG signal. However, I could not decode the value from the ECoG signal. Finally, I perfused and fixed the monkey’s brain and checked the condition of the implanted ECoG electrode. I found that to keep the good condition of the electrodes is important for ECoG signal recording and the decoding information from the ECoG signal.

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  • 脳内他者シミュレーションを利用した適応的行動選択を実現する脳内ネットワークの解明とその操作

    System name:研究助成

    Awarding organization:武田科学振興財団

    田中慎吾

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    Authorship:Principal investigator 

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Teaching Experience (researchmap)

Teaching Experience

  • 生理学実習

    2024
    Institution name:新潟大学

  • 人体の構造と機能I(生理学)

    2024
    Institution name:新潟大学