2021/08/06 更新

写真a

サトウ ヒロキ
佐藤 裕樹
SATO Hiroki
所属
医歯学総合病院 消化器内科 助教
職名
助教
外部リンク

学位

  • 医学博士 ( 2014年3月   新潟大学 )

経歴

  • 新潟大学   医歯学総合病院 消化器内科   助教

    2021年6月 - 現在

  • 新潟大学   医歯学総合研究科 分子細胞医学専攻 細胞機能   助教

    2019年12月 - 2021年5月

  • 新潟大学   医歯学総合病院 消化器内科   特任助教

    2018年6月 - 2019年11月

委員歴

  • 内視鏡的筋層切開術(POEM)ガイドライン作成委員 (消化器内視鏡学会)  

      詳細を見る

 

論文

  • Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis. 国際誌

    Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yosida, Yuzo Kawata, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Junji Yokoyama, Toshifumi Wakai, Shuji Terai

    Biochemistry and biophysics reports   25   100892 - 100892   2021年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It is reported that an increase in aerobic bacteria, a lack of short-chain fatty acids (SCFAs), and immune disorders in the diverted colon are major causes of diversion colitis. However, the precise pathogenesis of this condition remains unclear. The aim of the present study was to examine the microbiota, intestinal SCFAs, and immunoglobulin A (IgA) in the diverted colon. Eight patients underwent operative procedures for colostomies. We assessed the diverted colon using endoscopy and obtained intestinal samples from the diverted colon and oral colon in these patients. We analyzed the microbiota and SCFAs of the intestinal samples. The bacterial communities were investigated using a 16S rRNA gene sequencing method. The microbiota demonstrated a change in the proportion of some species, especially Lactobacillus, which significantly decreased in the diverted colon at the genus level. We also showed that intestinal SCFA values were significantly decreased in the diverted colon. Furthermore, intestinal IgA levels were significantly increased in the diverted colon. This study was the first to show that intestinal SCFAs were significantly decreased and intestinal IgA was significantly increased in the diverted colon. Our data suggest that SCFAs affect the microbiota and may play an immunological role in diversion colitis.

    DOI: 10.1016/j.bbrep.2020.100892

    PubMed

    researchmap

  • Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature.

    Osamu Shibata, Kenya Kamimura, Masayoshi Ko, Norihiro Sakai, Hiroyuki Abe, Shinichi Morita, Takeshi Mizusawa, Hiroki Sato, Akira Sakamaki, Shuji Terai

    Internal medicine (Tokyo, Japan)   2020年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Basic and clinical research have shown that the expression of molecules involved in the hepatocellular carcinoma cell signaling pathway is related to the sensitivity to molecular-targeted agents. We herein report a case of HCC that was effectively treated with lenvatinib after a poor response to sorafenib. The tumor showed a high expression of fibroblast growth factor receptor 4, which is reportedly related to the sensitivity to lenvatinib in vitro. The information obtained from this case and from our literature review highlights the importance of assessing the expression of the molecules involved in tumors for effective precision medicine.

    DOI: 10.2169/internalmedicine.6580-20

    PubMed

    researchmap

  • Usefulness of ultrasonography to assess the response to steroidal therapy for the rare case of type 2b immunoglobulin G4-related sclerosing cholangitis without pancreatitis: A case report. 国際誌

    Yuto Tanaka, Kenya Kamimura, Ryota Nakamura, Marina Ohkoshi-Yamada, Yohei Koseki, Takeshi Mizusawa, Satoshi Ikarashi, Kazunao Hayashi, Hiroki Sato, Akira Sakamaki, Junji Yokoyama, Shuji Terai

    World journal of clinical cases   8 ( 22 )   5821 - 5830   2020年11月

     詳細を見る

    記述言語:英語  

    BACKGROUND: A type 2b immunoglobulin G4 (IgG4)-related sclerosing cholangitis (SC) without autoimmune pancreatitis is a rare condition with IgG4-SC. While the variety of the imaging modalities have tested its usefulness in diagnosing the IgG4-SC, however, the usage of ultrasonography for the assessment of the response to steroidal therapy on the changes of bile duct wall thickness have not been reported in the condition. Therefore, the information of our recent case and reported cases have been summarized. CASE SUMMARY: We report the case of an 82-year-old Japanese man diagnosed with isolated IgG4-related SC based on the increase of serum IgG4, narrowing of the bile duct, its wall thickness, no complication of autoimmune pancreatitis, and IgG4 positive inflammatory cell infiltration to the wall with the fibrotic changes. The cholangiogram revealed type 2b according to the classification. Corticosteroid treatment showed a favorable effect, with the smooth decrease in serum IgG4 and the improvement of the bile duct wall thickness. CONCLUSION: As isolated type 2b, IgG4-SC is rare, the images, histological findings, and clinical course of our case will be helpful for physicians to diagnose and treat the new cases appropriately.

    DOI: 10.12998/wjcc.v8.i22.5821

    PubMed

    researchmap

  • Esophageal High-Resolution Manometry for Diagnosing the Severity of the Chronic Intestinal Pseudo-Obstruction: A Case Series. 国際誌

    Hiroki Sato, Kenya Kamimura, Hideaki Matsui, Takashi Owaki, Shinichi Morita, Yuto Tanaka, Natsuki Ishikawa, Yoshifumi Shimada, Junji Yokoyama, Toshifumi Wakai, Shuji Terai

    Digestive diseases and sciences   2020年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) is a severe and refractory intestinal motility disorder. However, due to its rarity and difficult histological investigation, its pathophysiology has not been characterized. AIM: Therefore, in this study, we aimed to determine the role of esophageal high-resolution manometry (HRM) in CIPO and the histological and clinical characteristics of the disease. METHODS: Patients with CIPO were analyzed for clinical characteristics; histological findings; and clinical courses after therapeutic intervention. In addition, HRM was performed to determine the esophageal involvement. RESULTS: Eleven patients were diagnosed with CIPO, and five required the long period of parenteral nutrition showing impaired esophageal motility including achalasia and absent contractility diagnosed with HRM. The four of these five cases showed acute onset of the CIPO following the triggering events of pregnancy, appendicitis, and surgery. In contrast, other six patients with normal or Jackhammer esophagus on HRM had moderate severity of CIPO with gradual onset. The histological analyses revealed that the loss of the intestinal neural ganglion cells and layers by inflammation, destruction, and atrophy are related to the severity of the clinical course of the disease and esophageal HRM findings of achalasia and absent contractility. CONCLUSIONS: HRM may be useful to diagnose the severity of the clinical course and to determine the therapeutic options for CIPO.

    DOI: 10.1007/s10620-020-06701-9

    PubMed

    researchmap

  • Cytapheresis for pyoderma gangrenosum associated with inflammatory bowel disease: A review of current status. 査読 国際誌

    Kentaro Tominaga, Kenya Kamimura, Hiroki Sato, Masayoshi Ko, Yuzo Kawata, Takeshi Mizusawa, Junji Yokoyama, Shuji Terai

    World journal of clinical cases   8 ( 11 )   2092 - 2101   2020年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pyoderma gangrenosum (PG) is a neutrophilic dermatosis clinically characterized by the presence of painful skin ulcerations with erythematous. As it is frequently associated with inflammatory bowel diseases, including ulcerative colitis, gastroenterologists should be familiar with the disease including therapeutic options. Therefore, we have conducted a review focusing on the cytapheresis for PG in cases of inflammatory bowel diseases. A literature search was conducted to extract studies published in the last 20 years, with information on demographics, clinical symptoms, treatment, and the clinical course from a total of 22 cases reported and our recent case. In most patients, cytapheresis was associated with improvement or resolution of PG after failure of conventional therapeutic options such as corticosteroids, antibiotics, immunosuppressive agents and immunoglobulin. Based on the information summarized, cytapheresis is helpful in the majority of patients with PG refractory to medical treatment associated with inflammatory bowel diseases and could be further studied in a multicenter, randomized trial.

    DOI: 10.12998/wjcc.v8.i11.2092

    PubMed

    researchmap

  • Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review. 査読

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Takeshi Mizusawa, Shinichi Morita, Yui Ishii, Nobutaka Takeda, Kazuki Natsui, Yuzo Kawata, Naruhiro Kimura, Yoshihisa Arao, Kazuya Takahashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   2020年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Ulcerative colitis, a chronic and recurrent inflammatory disease, is localized to the colonic mucosa but can affect other organs and lead to various complications. Gastroduodenitis associated with ulcerative colitis has been reported. However, little is known about esophageal ulcers. We herein report two rare cases of esophageal ulcers associated with ulcerative colitis. Furthermore, the clinical and histological characteristics of 18 previously reported cases are summarized. This case series and literature review will encourage the accurate diagnosis and treatment of esophageal ulcers associated with ulcerative colitis.

    DOI: 10.2169/internalmedicine.4437-20

    PubMed

    researchmap

  • Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis. 査読

    Kei Tomiyoshi, Hiroki Sato, Kentaro Tominaga, Yuzo Kawata, Daisuke Okamoto, Yoichi Kakuta, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   2020年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Thiopurine drugs are commonly used to treat immunologic diseases. However, the narrow therapeutic safety margin demands evidence-based precision medicine approaches. NUDT15 variants are associated with thiopurine-induced adverse events, particularly in Asians. We herein report a rare genotype of His/His in NUDT15 codon 139 in a case of ulcerative colitis and review the relevant literature. The patient experienced severe thiopurine-associated adverse events, including leukopenia and alopecia. There is no literature on the His/His genotype in NUDT15 codon 139, and our case suggests cautious use or the contraindication of thiopurines for patients with this genotype.

    DOI: 10.2169/internalmedicine.4261-19

    PubMed

    researchmap

  • Change in body composition in patients with achalasia before and after peroral endoscopic myotomy. 査読 国際誌

    Takeshi Mizusawa, Hiroki Sato, Kenya Kamimura, Satoru Hashimoto, Ken-Ichi Mizuno, Hiroteru Kamimura, Satoshi Ikarashi, Kazunao Hayashi, Masaaki Takamura, Junji Yokoyama, Shuji Terai

    Journal of gastroenterology and hepatology   35 ( 4 )   601 - 608   2020年4月

     詳細を見る

    記述言語:英語  

    BACKGROUND AND AIM: Patients with achalasia experience weight loss because of dysphagia caused by impaired relaxation of the lower esophageal sphincter. This study aimed to use dual bioelectrical impedance analysis (BIA) to determine the change in bodyweight and body composition in patients with achalasia before and after peroral endoscopic myotomy (POEM). METHODS: Patients with achalasia who underwent POEM from 2013 to 2018 (n = 72) were retrospectively analyzed for change in bodyweight before and after 3 months. Additionally, change in body composition was prospectively investigated in the final 10 of 72 patients using non-radiation dual BIA. RESULTS: Twenty patients (27.8%) were underweight (body mass index < 18.5) before undergoing POEM. No clinical parameters were identified to be associated with the underweight condition before POEM and be predictive of an increase in bodyweight after POEM. Low visceral fat volume observed on dual BIA correlated closely with the result obtained using computed tomography (Pearson correlation coefficient: r = 0.850, P < 0.01). Patients with achalasia had a statistically significant increase in visceral (P < 0.01) and subcutaneous fat volumes (P < 0.01) after POEM. Skeletal muscle mass index slightly increased (P = 0.02), although the value after POEM was still low. No blood biomarkers were indicators for low bodyweight or low visceral fat volume. CONCLUSIONS: Dual BIA is an effective non-invasive tool to evaluate the change in body composition of underweight patients with achalasia. Skeletal muscle volume was not enough after POEM, although a rapid increase in the intra-abdominal fat volume was observed. Additional studies are warranted to understand the pathological implications.

    DOI: 10.1111/jgh.14847

    PubMed

    researchmap

  • An unusual case of esophageal motility disorder. 査読 国際誌

    Youhei Koseki, Hiroki Sato, Shuji Terai

    Gastroenterology   2020年3月

     詳細を見る

  • Secondary Achalasia in Myotonic Dystrophy May Have a Different Pathology and Management. 査読

    Hiroki Sato, Ken-Ichi Mizuno, Satoru Hashimoto, Masafumi Takatsuna, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 6 )   875 - 875   2020年3月

     詳細を見る

  • Variation in small bowel transit time on capsule endoscopy. 査読 国際誌

    Kentaro Tominaga, Hiroki Sato, Hiroshi Yokomichi, Atsunori Tsuchiya, Tomoaki Yoshida, Yuzo Kawata, Takeshi Mizusawa, Junji Yokoyama, Shuji Terai

    Annals of translational medicine   8 ( 6 )   348 - 348   2020年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AME Publ Co  

    Background: Small bowel motility remains inadequately understood because of the complex and various functions as well as its anatomical position. The aimed of the study was to investigate the small bowel transit time (SBTT) of capsule endoscopy (CE) and to analyze the clinical factors affecting SBTT. Methods: SBTT was analyzed in patients who underwent small bowel CE. Factors contributing to SBTT and CE retention were investigated. Results: Among 397 patients enrolled in this study, 336 (84.6%) completed CE. The mean SBTT (± standard deviation) was 282.1±132.2 min. According to the univariate and multivariate analyses, aging and small bowel stenosis extended SBTT. In 38 patients who underwent multiple CE studies, considerable variation in SBTT were observed [mean of standard deviations (SDs) =97.97 min, SD of the SDs =81.99 min]. CE retention was observed in 61 patients (13.3%), and it was statistically associated to small bowel lesion. Conclusions: Aging and small bowel stenosis were associated with longer SBTT. Furthermore, SBTT analyzed by CE should be interpreted carefully considering the intra-individual differences in SBTT.

    DOI: 10.21037/atm.2020.02.40

    PubMed

    researchmap

  • Rare paradoxical adverse event in Crohn's disease: a case report. 査読 国際誌

    Marina Okoshi, Hiroki Sato, Terasu Honma, Shuji Terai

    Annals of translational medicine   8 ( 4 )   133 - 133   2020年2月

     詳細を見る

    記述言語:英語  

    An 18-year-old male adolescent diagnosed with ileocolitis-type Crohn's disease received therapy involving an anti-tumor necrosis factor-α (TNF-α) blocker, which resulted in remission for 2 years. The patient presented with fever, stomatitis, and cough with respiratory distress. Chest radiography revealed bilateral hilar lymphadenopathy; bronchoalveolar lavage showed high lymphocyte level: 40.8% and CD4/8 value: 3.9. Transbronchial lung biopsy identified multiple non-caseating granulomas fused to each other with connective tissue septa, leading to the diagnosis of sarcoidosis. The sarcoidosis was defined as a paradoxical adverse event (PAE) due to the use of TNF-α blocker; therefore, cessation of TNF-α blocker administration was sufficient to induce remission. We report a rare case of PAE on Crohn's disease. The characteristics and distinguishing histologies of PAE and Crohn's disease are described. Biological agent therapy has been reported to cause several PAEs during the treatment of immune-mediated inflammatory disorders. PAEs are defined as pathological conditions that occur during biological agent therapy usually effective in treatment. The laboratory, radiography, and histological findings shown in this case are useful for differential diagnosis and management of PAE.

    DOI: 10.21037/atm.2019.12.122

    PubMed

    researchmap

  • Septicemic listeriosis during adalimumab- and golimumab-based treatment for ulcerative colitis: case presentation and literature review. 査読

    Ryoko Horigome, Hiroki Sato, Terasu Honma, Shuji Terai

    Clinical journal of gastroenterology   13 ( 1 )   22 - 25   2020年2月

     詳細を見る

    記述言語:英語  

    Listeria monocytogenes is a common bacterium that can trigger an episode of amphixenosis from the consumption of contaminated food. It survives in the host as an intracellular parasite and can get reactivated when the host's immune system is compromised. The use of anti-tumor necrosis factor-α (TNF-α) blockers is reported to increase the risk of L. monocytogenes infections. In the field of gastroenterology, the use of TNF-α blockers is on the rise due to remarkable efficacy in select patients with inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn's disease and the rise in the incidence and prevalence of IBDs. There are few case reports on this topic, despite the rapid development of novel TNF-α blockers. Here, we report two cases of septicemic listeriosis encountered during treatment with the more recent TNF-α blockers, namely, adalimumab and golimumab, in ulcerative colitis and review the published literature on the topic.

    DOI: 10.1007/s12328-019-01005-6

    PubMed

    researchmap

  • Achalasia in a Patient with Myotonic Dystrophy. 査読

    Hiroki Sato, Ken-Ichi Mizuno, Satoru Hashimoto, Masafumi Takatsuna, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 1 )   67 - 68   2020年1月

     詳細を見る

    記述言語:英語  

    Myotonic dystrophy is a progressive disorder mainly affecting the voluntary muscles. We herein report a rare case of myotonic dystrophy complicated with high-resolution manometry-defined achalasia, the pathology of which is absent relaxation of the smooth muscles of lower esophageal sphincter (LES). In the present case, achalasia was considered a complication of myotonic dystrophy instead of sporadic achalasia, as on performing high-resolution manometry, the finding of an impaired LES relaxation (myotonic phase) changed to a totally emaciated LES function (muscle weakness phase) as myotonic dystrophy progressed.

    DOI: 10.2169/internalmedicine.3360-19

    PubMed

    researchmap

  • Endoscopic diverticulectomy for Zenker's diverticulum with heterotopic gastric mucosa. 査読 国際誌

    Hiroki Sato, Manabu Takeuchi, Shuji Terai

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   32 ( 1 )   145 - 145   2020年1月

     詳細を見る

    記述言語:英語  

    DOI: 10.1111/den.13529

    PubMed

    researchmap

  • Multicenter collaborative retrospective evaluation of peroral endoscopic myotomy for esophageal achalasia: analysis of data from more than 1300 patients at eight facilities in Japan. 査読 国際誌

    Hironari Shiwaku, Haruhiro Inoue, Manabu Onimaru, Hitomi Minami, Hiroki Sato, Chiaki Sato, Shinwa Tanaka, Ryo Ogawa, Norihiko Okushima

    Surgical endoscopy   34 ( 1 )   464 - 468   2020年1月

     詳細を見る

    記述言語:英語  

    BACKGROUND: Peroral endoscopic myotomy (POEM) is a novel, minimally invasive treatment for esophageal achalasia. We retrospectively examined and evaluated the results following POEM to verify the technique's efficacy and safety. METHODS: We retrospectively analyzed data for patients who underwent POEM at eight Japanese facilities between September 2008 and October 2015. Pre- and postoperative assessments 3 months and 1 year after POEM included patient interviews, endoscopy, and manometry. RESULTS: A total of 1346 patients underwent POEM during the study period. Achalasia was the straight type in 1105 patients (82%) and the sigmoid type in 241 patients (18%). The average patient age was 47.2 years (range 3-95 years); 617 patients (46%) were men and 729 (54%) were women. Previous treatment included balloon dilatation in 381 patients (28%) and Heller-Dor operation in 43 patients (3%). The average operation time was 99.6 min. The mean length of the myotomy in the esophageal body was 10.8 cm, and the myotomy extended into the stomach a mean of 2.8 cm. The response rate (Eckardt score ≤ 3) was 95.1% 3 months postoperatively and 94.7% 1 year postoperatively. We noted 50 adverse events (3.7%) of Clavien-Dindo classification grade ≤ IIIa, and all resolved with conservative treatment. There were no Clavien-Dindo classification grade ≥ IIIb adverse events. After POEM, erosive esophagitis according to the Los Angeles classification was absent in 37% of the patients, grade A in 33%, B in 24%, C in 6%, and D in 0.2%. Symptomatic gastroesophageal reflux disease after POEM was confirmed in 14.8% of the patients; both erosive esophagitis and symptomatic gastroesophageal reflux disease responded to treatment with a proton-pump inhibitor. CONCLUSION: Our results confirmed the safety and efficacy of POEM in a large patient series and support POEM as the first-line and standard treatment for esophageal achalasia.

    DOI: 10.1007/s00464-019-06833-8

    PubMed

    researchmap

  • Rare case of circumferential esophageal peeling 査読

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Yui Ishii, Nobutaka Takeda, Kazuki Natsui, Yuzo Kawata, Naruhiro Kimura, Yoshihisa Arao, Suguru Takeuchi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    Clinical Case Reports   2020年

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

    © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This report highlights the easy peeling of the esophageal epithelium with Nikolsky phenomenon after swallowing the foreign body and the healing status of the esophagus only 3 days later in a patient of pemphigus vulgaris.

    DOI: 10.1002/ccr3.2846

    Scopus

    researchmap

  • Efficacy of gelatin hydrogels incorporating triamcinolone acetonide for prevention of fibrosis in a mouse model. 査読 国際誌

    Nao Nakajima, Satoru Hashimoto, Hiroki Sato, Kazuya Takahashi, Takuro Nagoya, Kenya Kamimura, Atsunori Tsuchiya, Junji Yokoyama, Yuichi Sato, Hanako Wakatsuki, Masayuki Miyata, Yusuke Akashi, Ryusuke Tanaka, Ken Matsuda, Yasuhiko Tabata, Shuji Terai

    Regenerative therapy   11   41 - 46   2019年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Introduction: Triamcinolone acetonide (TA), a steroid, is often used clinically to prevent dysfunctions associated with fibrosis. The objective of this study was to examine whether TA can be suspended in a gelatin sheet for tissue engineering using a mouse skin wound model. Methods: TA was suspended in biodegradable gelatin and freeze-dried in a sheet form. The sheet was analyzed for homogeneity and controlled release of TA by high-performance liquid chromatography. We made two skin wounds on the dorsal side of mice. Gelatin sheets with TA (TA sheet) and without TA (control sheet) were attached to each skin wound. To determine the efficacy of the prepared TA sheet on the skin wounds, TA-sheet versus TA-injection experiments were conducted. Hematoxylin and eosin staining was performed to assess the grade of epithelialization and alpha smooth muscle actin (α-SMA) immunohistochemical staining was conducted to evaluate myofibroblast infiltration. Results: In the TA-release test in vitro, 7.7 ± 2.3% of TA was released from the sheet by 24 h. After replacing the initial phosphate-buffered saline (PBS) with collagenase PBS, the amount of released TA increased over time. The wound area/original skin wound area after 15 days with the TA sheet was significantly larger than that with the control sheet (26.9 ± 5.5% vs 10.7 ± 2.6%, p = 0.023). The α-SMA positive area/whole area with the TA sheet was significantly lower than that with the control sheet (4.65 ± 0.66% vs 7.24 ± 0.7%, p = 0.023). Furthermore, the α-SMA positive area/whole area with the TA sheet was significantly lower than that with TA injection (5.32 ± 0.45% vs 7.93 ± 0.75%, p = 0.013). Conclusions: We developed a TA sheet and confirmed both the homogeneity of the suspended TA and controlled-release of the TA in the presence of collagenase in vitro. The TA sheet caused less myofibroblast infiltration into the tissue than the control sheet or TA injection did.

    DOI: 10.1016/j.reth.2019.04.001

    PubMed

    researchmap

  • Rare case of systemic scleroderma showing full-layer histologic features of an ileal lesion. 査読 国際誌

    Hiroki Sato, Terasu Honma, Saki Yamada, Takashi Owaki, Shuji Terai

    Gastrointestinal endoscopy   90 ( 6 )   991 - 993   2019年12月

     詳細を見る

  • Paradigm shift in esophageal diverticulum treatment: is the peroral endoscopic myotomy (POEM) technique the best method? 査読 国際誌

    Hiroki Sato

    Endoscopy   51 ( 12 )   1117 - 1118   2019年12月

     詳細を見る

    記述言語:英語  

    DOI: 10.1055/a-1012-1977

    PubMed

    researchmap

  • Peroral endoscopic myotomy for achalasia: a prospective multicenter study in Japan. 査読 国際誌

    Hironari Shiwaku, Haruhiro Inoue, Hiroki Sato, Manabu Onimaru, Hitomi Minami, Shinwa Tanaka, Chiaki Sato, Ryo Ogawa, Norihiko Okushima, Hiroshi Yokomichi

    Gastrointestinal endoscopy   Online first   2019年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MOSBY-ELSEVIER  

    BACKGROUND AND AIMS: Peroral endoscopic myotomy (POEM) is an available treatment modalities for achalasia. The reported efficacy of POEM in the only prospective multicenter study was 82%; however, a retrospective multicenter study in Japan reported a higher efficacy rate of 95%. The aim of this study was to prospectively verify treatment outcomes after POEM at multiple facilities in Japan. METHODS: This was a prospective single-arm trial of POEM for achalasia at 8 facilities in Japan between April 2016 and March 2018 to evaluate its safety and efficacy. Patients were re-evaluated at 3 months and up to 1 year after POEM. RESULTS: Among the 233 patients with achalasia who underwent POEM, procedure-related adverse events occurred in 24 patients (10.3%), none of whom required surgical intervention. In the 207 patients satisfying the inclusion criteria, the efficacy rate of POEM, defined by an Eckardt score ≤3 at 1 year, was 97.4% (95% CI, 95.3%-99.7%). The Eckardt score decreased significantly from 6.6 ± 2.0 preoperatively to 1.1 ± 1.1, 1 year after POEM. Postoperative reflux esophagitis, severe reflux esophagitis, and symptomatic GERD were reported in 54.2%, 5.6%, and 14.7%, respectively, and proton pump inhibitors were administered in 21.1%. CONCLUSIONS: Our prospective multicenter study in Japan showed greater efficacy of POEM for achalasia compared with the results of a previous prospective multicenter study. POEM is safe and highly effective for at least 1 year. (Clinical trial registration number: UMIN 000021550.).

    DOI: 10.1016/j.gie.2019.11.020

    PubMed

    researchmap

  • Methotrexate-related lymphoproliferative disorders in the liver: Case presentation and mini-review. 査読 国際誌

    Takeshi Mizusawa, Kenya Kamimura, Hiroki Sato, Takeshi Suda, Hiroyuki Fukunari, Go Hasegawa, Osamu Shibata, Shinichi Morita, Akira Sakamaki, Junji Yokoyama, Yu Saito, Yoshihisa Hori, Yuduru Maruyama, Fumitoshi Yoshimine, Takahiro Hoshi, Shinichi Morita, Tsutomu Kanefuji, Masaaki Kobayashi, Shuji Terai

    World journal of clinical cases   7 ( 21 )   3553 - 3561   2019年11月

     詳細を見る

    記述言語:英語  

    BACKGROUND: Immunosuppression is effective in treating a number of diseases, but adverse effects such as bone marrow suppression, infection, and oncogenesis are of concern. Methotrexate is a key immunosuppressant used to treat rheumatoid arthritis. Although it is effective for many patients, various side effects have been reported, one of the most serious being methotrexate-related lymphoproliferative disorder. While this may occur in various organs, liver involvement is rare. Information on these liver lesions, including clinical characteristics, course, and imaging studies, has not been summarized to date. CASE SUMMARY: We present a case of 70-year-old woman presented with a 2-wk history of fever and abdominal pain. She had had rheumatoid arthritis for 5 years and was being treated with medication including methotrexate. Contrast-enhanced computed tomography revealed multiple low density tumors in the liver and the histological analyses showed significant proliferation of lymphocytes in masses that were positive on immunohistochemical staining for CD3, CD4, CD8, and CD79a but negative for CD20 and CD56. Staining for Epstein-Barr virus-encoded RNA was negative. And based on these findings, the liver tumors were diagnosed as Methotrexate-related lymphoproliferative disorders. A time-dependent disappearance of the liver tumors after stopping methotrexate supported the diagnoses. CONCLUSION: The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder.

    DOI: 10.12998/wjcc.v7.i21.3553

    PubMed

    researchmap

  • Overlap in disease concept of functional esophageal disorders and minor esophageal motility disorders. 査読 国際誌

    Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Yuzo Kawata, Takeshi Mizusawa, Kentaro Tominaga, Junji Yokoyama, Shuji Terai

    Journal of gastroenterology and hepatology   34 ( 11 )   1940 - 1945   2019年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIM: Functional gastrointestinal disorders are the most common disorders in gastroenterology and are currently considered as gut-brain interaction disorders with multiple related factors including motility disturbance. However, high-resolution manometry (HRM) had revealed a new disease concept known as minor esophageal motility disorders. This study aimed to investigate the correlation between functional esophageal disorders (FEDs) and minor esophageal motility disorders. METHODS: Functional esophageal disorders were diagnosed using upper endoscopy, pH monitoring, and HRM, to exclude achalasia, esophago-gastric junction outflow obstruction, and other major esophageal motility disorders. FEDs with or without minor esophageal motility disorders were compared using the Chicago classification. RESULTS: Twelve healthy volunteers also subjected to HRM showed no minor esophageal motility disorders. Of the 40 patients with FEDs, 15 (37.5%) were diagnosed with minor esophageal motility disorders. Characteristics were not different between patients with and without minor esophageal motility disorders (sex: P = 0.609, age: P = 0.054, body mass index: P = 0.137, and presence of psychiatric disorders: P = 0.404). The type and location of symptoms were not related to the comorbidity rate of minor esophageal motility disorders (P = 0.744 and 0.094). No patients with FEDs developed major esophageal motility disorders. CONCLUSIONS: Minor esophageal motility disorders were frequently observed in FEDs, but the causal relationship between esophageal symptoms remains unclear. The disease concepts of FEDs and minor esophageal motility disorders are considered to overlap and are both independent of major esophageal motility disorders.

    DOI: 10.1111/jgh.14691

    PubMed

    researchmap

  • Eosinophilic esophagitis after total gastrectomy treated with proton pump inhibitors: a case report. 査読

    Takashi Owaki, Hiroki Sato, Ryoko Horigome, Satoru Hashimoto, Terasu Honma, Shuji Terai

    Clinical journal of gastroenterology   12 ( 5 )   420 - 423   2019年10月

     詳細を見る

    記述言語:英語  

    Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder in the esophagus characterized by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation. EoE and Gastro Esophageal Reflux Disease (GERD) are known not to be mutually exclusive and share a complex relationship. Proton pump inhibitors (PPIs), which are generally used in the treatment of GERD, could be used to treat esophageal eosinophilia in suspected EoE. We report a rare case of EoE after total gastrectomy that responded to PPIs. Our case indicates that the onset of EoE does not necessarily require an acid reflux-induced antigen-mediated drive, and the action of PPIs in patients with active EoE is unrelated to gastric acid suppression.

    DOI: 10.1007/s12328-019-00960-4

    PubMed

    researchmap

  • Epidemiological analysis of achalasia in Japan using a large-scale claims database. 査読

    Hiroki Sato, Hiroshi Yokomichi, Kazuya Takahashi, Kentaro Tominaga, Takeshi Mizusawa, Naruhiro Kimura, Yuzo Kawata, Shuji Terai

    Journal of gastroenterology   54 ( 7 )   621 - 627   2019年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Achalasia is a well-known esophageal motility disorder, but epidemiological studies in Japan are lacking. We investigated the incidence and period prevalence of achalasia in Japan, including the rate of coexistence of esophageal carcinoma, and evaluated treatment trends. METHODS: To estimate the nationwide number of patients with achalasia, a large-scale insurance claims database from 2005 to 2017 were used for our analyses. Patients with achalasia and coexistence of esophageal carcinoma were identified based on the diagnosis code registered. Interventional treatment was also evaluated. RESULTS: Of the total 5,493,650 populations, 385 were diagnosed with primary achalasia. The incidence was calculated as 0.81-1.37 per 100,000 person-years (male-to-female ratio was almost 1; mean age at diagnosis was 43.3 ± 14.4 years). The period prevalence was 7.0 per 100,000 persons. There were statistically significant trends of increase in the incidence and period prevalence over age groups (all p values < 0.0001). Four men with achalasia developed esophageal carcinoma, and the incidence of esophageal carcinoma with achalasia was estimated as 0.25 per 100 person-years. With regard to intervention, esophageal dilation was performed as a first treatment in 64.7% of patients, with repeat intervention required in 56.9% of these. The proportion of patients treated using peroral endoscopic myotomy (POEM) increased annually to 41.1% in 2017. CONCLUSIONS: In Japan, the incidence and period prevalence of achalasia is comparable to that in other countries. The absolute risk of esophageal carcinoma is rather low. Esophageal dilation has been the mainstay of achalasia treatment, and the role of POEM has increased annually.

    DOI: 10.1007/s00535-018-01544-8

    PubMed

    researchmap

  • Evaluating the effect of injecting triamcinolone acetonide in two sessions for preventing esophageal stricture after endoscopic submucosal dissection. 査読 国際誌

    Satoru Hashimoto, Ken-Ichi Mizuno, Kazuya Takahashi, Hiroki Sato, Junji Yokoyama, Manabu Takeuchi, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    Endoscopy international open   7 ( 6 )   E764-E770 - E770   2019年6月

     詳細を見る

    記述言語:英語  

    Background and study aims  Several previous reports indicate that endoscopic injection of triamcinolone acetonide (TA) after widespread endoscopic submucosal dissection (ESD) is effective for preventing esophageal stricture. We investigated the efficacy of injecting TA in two sessions for preventing stricture formation post-ESD. Patients and methods  Sixty-six consecutive patients with widespread mucosal defects that affected more than three-fourths of the circumference of the esophagus were included. The study group (n = 40) received TA injections over two sessions: immediately after and 14 days after ESD. The control group (n = 26) did not receive a TA injection. This study was performed retrospectively against historical controls. The primary endpoint of this study was frequency of stricture after TA injection. The secondary endpoint was number of required endoscopic balloon dilations (EBDs) after TA injection. Results  The post-ESD stricture rate among patients who had subcircumferential mucosal defects was 45.7 % in the study group (16/35 patients), which was significantly lower than the rate of 73.9 % in the control group (17/23 patients; P  = 0.031). The number of EBD procedures required was significantly lower in the study group (median 0, range 0 - 7) than in the control group (median 4, range 0 - 20; P  < 0.001). There was no significant difference between the study and control groups among the patients who had full circumferential mucosal defects. Conclusion  This study showed that performing two sessions of TA injection is an effective and safe treatment for prevention of esophageal stricture following subcircumferential ESD.

    DOI: 10.1055/a-0894-4374

    PubMed

    researchmap

  • Co-existent ulcerative colitis and Guillain-Barré syndrome: a case report and literature review. 査読

    Tominaga K, Tsuchiya A, Sato H, Kimura A, Oda C, Hosaka K, Kawata Y, Kimura N, Hayashi K, Yokoyama J, Terai S

    Clinical journal of gastroenterology   12 ( 3 )   243 - 246   2019年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12328-019-00939-1

    PubMed

    researchmap

  • A Rare Case Involving the Inability to Belch. 査読

    Hiroki Sato, Shunzo Ikarashi, Shuji Terai

    Internal medicine (Tokyo, Japan)   58 ( 7 )   929 - 931   2019年4月

     詳細を見る

    記述言語:英語  

    A 17-year-old girl was referred to our hospital with an inability to belch, while experiencing chest gurgling noises, and severe abdominal bloating. She reported having these symptoms all her life. A timed barium esophagogram revealed a moderate amount of bubbles in the esophagus and gastric fundus, which significantly increased after the examination. High resolution manometry revealed that the basal upper esophageal sphincter pressure increased with a rise in the cervical esophageal pressure. A pathological inability to belch is rare; at present, no specific name exists to describe the disorder. Further research is needed in this unexplored field.

    DOI: 10.2169/internalmedicine.1908-18

    PubMed

    researchmap

  • Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment. 査読 国際誌

    Hiroki Sato, Manabu Takeuchi, Satoru Hashimoto, Ken-Ichi Mizuno, Koichi Furukawa, Akito Sato, Junji Yokoyama, Shuji Terai

    World journal of gastroenterology   25 ( 12 )   1457 - 1464   2019年3月

     詳細を見る

    記述言語:英語  

    Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant, minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy (POEM). However, the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience.

    DOI: 10.3748/wjg.v25.i12.1457

    PubMed

    researchmap

  • Clinical and pathological profile of eosinophilic gastroenteritis. 査読 国際誌

    Hiroki Sato, Terasu Honma, Takashi Owaki, Kentaro Tominaga, Junji Yokoyama, Shuji Terai

    European journal of gastroenterology & hepatology   31 ( 2 )   157 - 162   2019年2月

     詳細を見る

    記述言語:英語  

    BACKGROUND: Eosinophilic gastroenteritis (EoGE) can be diagnosed on the basis of histologic criteria; however, the pathology is considered to be heterogeneous. There is no consensus on the management of this enigmatic disorder with an unknown etiology. PATIENTS AND METHODS: Data for patients diagnosed with EoGE and followed up over a 1-year period were analyzed. Their symptoms, patterns of flares, and type of treatment were documented. The shift in peripheral blood eosinophil levels was also examined. RESULTS: A total of 10 (mean age, 44 years; range: 31-70 years; women, 5) patients were diagnosed with EoGE. The most frequent presenting symptom was abdominal pain, and eight patients were classified with mucosal type of EoGE. Chronic disease or multiple flares were observed in seven out of 10 (70.0%) patients, and all of them had a history of allergy. Four were corticosteroid dependent (three relapsed during corticosteroid tapering and one following corticosteroid withdrawal). One of them received anti-IL5 monoclonal antibody that enabled corticosteroid dose tapering. In four patients with highly elevated initial eosinophil levels at diagnosis, the peripheral eosinophil level correlated with the amelioration and deterioration of their symptoms. The remaining three patients had a single flare without relapse. Two had no history of allergy. CONCLUSION: EoGE is a unique disorder with a variable clinical course. Although further studies are required to confirm our observations, the presence of other allergic disorders is associated with chronicity or multiple flares. Peripheral eosinophil level may be an effective biomarker for recurrence in patients with severe systemic disorders at diagnosis.

    DOI: 10.1097/MEG.0000000000001241

    PubMed

    researchmap

  • Clinical practice guidelines for peroral endoscopic myotomy. 査読

    Inoue H, Shiwaku H, Iwakiri K, Onimaru M, Kobayashi Y, Minami H, Sato H, Kitano S, Iwakiri R, Omura N, Murakami K, Fukami N, Fujimoto K, Tajiri H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   30 ( 5 )   563 - 579   2018年9月

  • Eosinophilic Esophageal Myositis (EoEM) Causes Jackhammer Esophagus, Rarely Posing a Problem in the Differential Diagnosis of Eosinophilic Esophagitis 査読

    Hiroki Sato, Shuji Terai

    American Journal of Gastroenterology   113 ( 8 )   1 - 2   2018年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nature Publishing Group  

    DOI: 10.1038/s41395-018-0171-z

    Scopus

    PubMed

    researchmap

  • IS ENDOSCOPIC SUBMUCOSAL DISSECTION A FEASIBLE TREATMENT FOR ESOPHAGOGASTRIC JUNCTION CANCER? 査読

    Takahashi Kazuya, Hashimoto Satoru, Mizuno Kenichi, Sato Hiroki, Tominaga Kentaro, Kohisa Junji, Ikarashi Satoshi, Hayashi Kazunao, Yokoyama Junji, Terai Shuji

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB396 - AB397   2018年6月

  • IS ENDOSCOPIC SUBMUCOSAL DISSECTION VALUABLE FOR ELDERLY PATIENTS WITH SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA? 査読

    Hashimoto Satoru, Mizuno Kenichi, Takahashi Kazuya, Sato Hiroki, Tominaga Kentaro, Kohisa Junji, Ikarashi Satoshi, Hayashi Kazunao, Yokoyama Junji, Terai Shuji

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB287   2018年6月

  • Esophageal motility disorders: new perspectives from high-resolution manometry and histopathology 査読

    Hiroki Sato, Kazuya Takahashi, Ken-ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Go Hasegawa, Shuji Terai

    Journal of Gastroenterology   53 ( 4 )   484 - 493   2018年4月

     詳細を見る

    記述言語:英語   出版者・発行元:Springer Tokyo  

    High-resolution manometry (HRM) and peroral endoscopic myotomy (POEM) have contributed significantly to the field of esophageal motility disorders in recent years. The development of HRM has categorized various esophageal motility disorders with a focus on a diverse range of manometric anomalies. Additionally, the Chicago classification criteria is widely used for manometric diagnosis. Moreover, POEM was introduced as a minimally invasive radical therapy for achalasia and shows promise for other spastic esophageal motility disorders as well. POEM has also enabled a transluminal endoscopic approach for determining the histology of the esophageal muscle layer, which is expected to assist in elucidating the etiology of disorders associated with esophageal motility. The purpose of this review is to update the diagnosis, pathology, and treatment of esophageal motility disorders, with a focus on the recent advances in this field.

    DOI: 10.1007/s00535-017-1413-3

    Scopus

    PubMed

    researchmap

  • A clinical study of peroral endoscopic myotomy reveals that impaired lower esophageal sphincter relaxation in Achalasia is not only defined by high-resolution manometry 査読

    Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai

    PLoS ONE   13 ( 4 )   e0195423   2018年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Public Library of Science  

    Background and aim Achalasia is an esophageal motility disorder characterized by impaired lower esophageal sphincter (LES) relaxation. On high-resolution manometry (HRM), impaired LES relaxation is defined by elevated integrated relaxation pressure (IRP). However, a new category of Achalasia within the normal IRP range has been suggested. Methods HRM was performed using a Starlet device and an IRP threshold of 26 mmHg. Peroral endoscopic myotomy (POEM) was performed for cases of Achalasia diagnosed using established methods. During POEM, the histology of the LES was assessed. Follow-up was performed 2 months post-operatively. Results Forty-one patients with Achalasia (18 women, mean age 53 ± 18.6 years) were included. Among them, 27 were placed in the IRP &gt
    26 mmHg subgroup (impaired LES relaxation on HRM) and 14 in the IRP ≤ 26 mmHg subgroup (normal LES relaxation on HRM). In the IRP ≤ 26 mmHg subgroup, patients were older, had longer symptom duration, and had more esophageal dilation. The IRP ≤ 26 mmHg subgroup had the same symptom severity as the higher IRP subgroup and POEM significantly improved symptoms and IRP, although four patients still had severe LES fibrosis. Conclusions The clinical presentation of Achalasia has a gap between a HRM-defined impaired LES relaxation, with aging or disease progression considered reasons for a lowered LES pressure. POEM can be a feasible treatment option, even for cases of Achalasia with a normal IRP. However, patients with severe LES fibrosis need more attention for the therapeutic indication.

    DOI: 10.1371/journal.pone.0195423

    Scopus

    PubMed

    researchmap

  • Full-layer mucosal histology in achalasia: Histological epithelial wave is characteristic in “pinstripe pattern”-positive achalasia 査読

    H. Sato, K. Takahashi, N. Nakajima, G. Hasegawa, K. Mizuno, S. Hashimoto, S. Ikarashi, K. Hayashi, Y. Honda, J. Yokoyama, Y. Sato, S. Terai

    Neurogastroenterology and Motility   30 ( 1 )   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing Ltd  

    Background: Previously, the mucosal histology in achalasia has only been investigated using superficial biopsy or surgically resected esophageal specimens in end-stage cases. We investigated the histology of the full-layer mucosa in early and advanced achalasia. Methods: Endoscopy was performed for the pinstripe pattern (PSP) (an early achalasia indicator) and dilation and thickening of the mucosa (advanced achalasia indicators). A mucosal entry site for peroral endoscopic myotomy was created using cap-fitted endoscopic mucosal resection to access the full-layer mucosa and the submucosa. Key Results: Mucosal histology was compared between 32 patients with achalasia and 15 controls. Histological esophagitis with findings of inflammatory cell infiltration and dilated intercellular spaces was observed more in patients with achalasia than in controls (87.5% vs 13.3%, P&lt
    .001
    84.4% vs 46.7%, P=.049). Muscularis mucosae (MM) atrophy and epithelial wave were only observed in achalasia (40.6% vs 0%, P=.005
    28.1% vs 0%, P=.043). Fibrosis was more common in achalasia, but without statistical significance (31.3% vs 20.0%, P=.503). In achalasia with endoscopic dilation and thickening of the mucosa, MM atrophy was observed histologically, and in cases involving endoscopic PSP, the histological epithelial wave was observed. Conclusions &amp
    Inferences: Histological findings of esophagitis were observed endoscopically even in early achalasia. Pinstripe pattern corresponds to the epithelial wave observed histologically in achalasia, whereas endoscopic findings in advanced achalasia correspond to MM atrophy. Appropriate management is necessary during early achalasia to prevent progression to advanced achalasia with more severe histological changes.

    DOI: 10.1111/nmo.13168

    Scopus

    researchmap

  • Eosinophilic esophagitis in Japanese patients: A mild and slow-progressing disorder. 査読 国際誌

    Hiroki Sato, Terasu Honma, Yujiro Nozawa, Takashi Owaki, Michitaka Imai, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Toru Ishikawa, Toshiaki Yoshida, Shuji Terai

    PloS one   13 ( 11 )   e0206621   2018年

     詳細を見る

    記述言語:英語  

    BACKGROUND AND AIM: Awareness of eosinophilic esophagitis (EoE) has gradually increased in Japan, therefore the characteristics of this disease in the Japanese patient population need to be elucidated. This study aimed to investigate the features of EoE in the Japanese population. METHODS: During a 2-year period, all gastrointestinal endoscopies were performed with maximum attention being paid to identify EoE through endoscopic findings. Clinical features and findings were analyzed among this population. RESULTS: Among a total of 8589 patients (general gastrointestinal endoscopy, performed for evaluation of symptoms or disease follow-up: 3669; medical check-up endoscopy, routinely performed in asymptomatic patients: 4920), 17 patients (0.20%) were diagnosed with esophageal eosinophilia (mean age ± standard deviation: 44±11.9 years; 1 female). Only 6 patients with esophageal eosinophilia were diagnosed by general gastrointestinal endoscopy; among them, 3 patients had dysphagia and 3 were asymptomatic. The remaining 11 patients were diagnosed by medical check-up endoscopy. All patients were treated with a proton pump inhibitor (PPI); 5 were diagnosed with EoE and 12 with PPI responsive esophageal eosinophilia. Chronological endoscopy analysis showed that EoE findings could be observed for a mean of 6.1 years prior to diagnosis, and the disease did not significantly progress in severity. CONCLUSIONS: Most Japanese patients with EoE have mild and slowly progressing disease, which can be diagnosed when close attention is paid to the endoscopic findings. Medical check-up endoscopy in Japan could be a great opportunity for the early diagnosis of EoE.

    DOI: 10.1371/journal.pone.0206621

    PubMed

    researchmap

  • A rare case of concomitant type III achalasia and chronic idiopathic intestinal pseudo-obstruction. 査読

    Sato H, Abe H, Nagashima A, Yokoyama J, Terai S

    J Gastroenterol Hepatol   33 ( 3 )   559   2018年

     詳細を見る

  • Gastrointestinal: A case of hypereosinophilic syndrome with esophageal involvement. 査読

    Takahashi K, Sato H, Tominaga K, Kohisa J, Ikarashi S, Hayashi K, Miuzno K, Hashimoto S, Yokoyama J, Terai S

    J Gastroenterol Hepatol   33 ( 11 )   1817   2018年

     詳細を見る

  • Prevention of esophageal stricture after endoscopic submucosal dissection using RNA-based silencing of carbohydrate sulfo-transferase 15 in a porcine model 査読

    Hiroki Sato, Seiji Sagara, Nao Nakajima, Teppei Akimoto, Kenji Suzuki, Hiroyuki Yoneyama, Shuji Terai, Naohisa Yahagi

    ENDOSCOPY   49 ( 5 )   491 - 497   2017年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:GEORG THIEME VERLAG KG  

    Background and study aims Endoscopic submucosal dissection (ESD) for esophageal carcinoma frequently causes fibrotic strictures that require treatment. A possible preventive effect of small interfering RNA (siRNA) targeting carbohydrate sulfotransferase 15 (CHST15) on esophageal stricture formation after ESD was investigated in 3 pigs.
    Materials and methods Two half-circumferential ESD ulcers were created in the oral and anal ends of the esophagus. CHST15 siRNA was injected submucosally in one of the two ESD ulcers. Endoscopic, macroscopic, histological, and polymerase chain reaction analyses were performed.
    Results On post-operative day 14, the non-treated ulcers were found to show histological fibrosis and increased expression of the CHST15 messenger RNA. A single endoscopic injection of CHST15 siRNA alleviated stricture development in post-ESD ulcers with significant reduction in the mucosal contraction rate. The deposition of collagen and accumulation of fibroblasts and myofibroblasts were diminished in ulcers treated with CHST15 siRNA, where significant suppression of CHST15, transforming growth factorbeta (TGF-beta), and collagen-1 messenger RNAs was also seen.
    Conclusion CHST15 siRNA alleviated esophageal postESD stricture formation via repression of fibrosis, revealing a novel therapeutic role for antifibrotic agents in the prevention of post-ESD strictures.

    DOI: 10.1055/s-0042-123189

    Web of Science

    PubMed

    researchmap

  • Development and use of a non-biomaterial model for hands-on training of endoscopic procedures 査読

    Hiroki Sato, Ken-Ichi Mizuno, Yuichi Sato, Satoru Hashimoto, Kazunao Hayashi, Satoshi Ikarashi, Yutaka Honda, Junji Yokoyama, Shuji Terai

    Annals of Translational Medicine   5 ( 8 )   182   2017年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AME Publishing Company  

    Background: Endoscopic submucosal dissection (ESD) and peroral endoscopic myotomy (POEM) are recently developed techniques that have the potential to significantly improve clinical outcomes. However, training opportunities on these techniques remain limited. To address this issue, we developed a novel ex-vivo ESD/POEM training model. Our aim in this paper is to describe the model and provide preliminary evidence of promising feasibility to improve access to ESD/POEM training. Methods: The model was developed using polyvinyl alcohol hydrogel, which can easily be modified to reproduce the stiffness of the different intestinal layers, namely the mucosa, submucosa, and muscle layer. Results: A training workshop, using our ex-vivo model, was held for 28 residents. Satisfaction and feasibility in using the ex-vivo model for endoscopic training were evaluated by using a self-report questionnaire. All participants were satisfied with their training experience (100% satisfaction rate), with 27 of the 28 participants reporting that the model was feasible in replicating all components of the ESD/POEM technique (96.4% feasibility rate). Conclusions: Based on this feedback, we propose that our non-biomaterial model has the feasibility to provide an effective endoscopy education tool and a satisfactory training experience.

    DOI: 10.21037/atm.2017.01.27

    Scopus

    PubMed

    researchmap

  • Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis 査読

    Hiroki Sato, Nao Nakajima, Kazuya Takahashi, Go Hasegawa, Ken-ichi Mizuno, Satoru Hashimoto, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

    WORLD JOURNAL OF GASTROENTEROLOGY   23 ( 13 )   2414 - 2423   2017年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BAISHIDENG PUBLISHING GROUP INC  

    AIM
    To define clinical criteria to differentiate eosinophilic gastrointestinal disorder (EoGD) in the esophagus.
    METHODS
    Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis (EoE), subepithelial eosinophilic esophagitis (sEoE) and eosinophilic esophageal myositis (EoEM), identified by endoscopy, manometry and serum immunoglobulin E levels (s-IgE), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples.
    RESULTS
    In five patients with EoE, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with sEoE and four with EoEM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with EoE and sEoE with some variation, while EoEM was associated with hypercontractile or hypertensive peristalsis, with elevated s-IgE. Histology revealed the following eosinophils per high-power field values. EoE = 41.4 +/- 7.9 in the epithelium and 2.3 +/- 1.5 in the subepithelium; sEoE = 3 in the epithelium and 35 in the subepithelium (conventional biopsy); EoEM = none in the epithelium, 10.7 +/- 11.7 in the subepithelium (conventional biopsy or endoscopic mucosal resection) and 46.8 +/- 16.5 in the muscularis propria (peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to EoE. Eotaxin-3, IL-5 and IL-13 were overexpressed in EoE.
    CONCLUSION
    Based on clinical and histological data, we identified criteria, which differentiated between EoE, sEoE and EoEM, and reflected a different pathogenesis between these esophageal EoGDs.

    DOI: 10.3748/wjg.v23.i13.2414

    Web of Science

    PubMed

    researchmap

  • Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia 査読

    N. Nakajima, H. Sato, K. Takahashi, G. Hasegawa, K. Mizuno, S. Hashimoto, Y. Sato, S. Terai

    NEUROGASTROENTEROLOGY AND MOTILITY   29 ( 3 )   2017年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    BackgroundHistopathology of muscularis externa in primary esophageal motility disorders has been characterized previously. We aimed to correlate the results of high-resolution manometry with those of histopathology.
    MethodsDuring peroral endoscopic myotomy, peroral esophageal muscle biopsy was performed in patients with primary esophageal motility disorders. Immunohistochemical staining for c-kit was performed to assess the interstitial cells of Cajal (ICCs). Hematoxylin Eosin and Azan-Mallory staining were used to detect muscle atrophy, inflammation, and fibrosis, respectively.
    Key ResultsSlides from 30 patients with the following motility disorders were analyzed: achalasia (type I: 14, type II: 5, type III: 3), one diffuse esophageal spasm (DES), two outflow obstruction (OO), four jackhammer esophagus (JE), and one nutcracker esophagus (NE). ICCs were preserved in high numbers in type III achalasia (n=9.41.2 cells/high power field [HPF]), compared to types I (n=3.7 +/- 0.3 cells/HPF) and II (n=3.5 +/- 1.0 cells/HPF). Moreover, severe fibrosis was only observed in type I achalasia and not in other types of achalasia, OO, or DES. Four of five patients with JE and NE had severe inflammation with eosinophilic infiltration of the esophageal muscle layer (73.8 +/- 50.3 eosinophils/HPF) with no epithelial eosinophils. One patient with JE showed a visceral myopathy pattern.
    Conclusions & InferencesCompared to types I and II, type III achalasia showed preserved ICCs, with variable data regarding DES and OO. In disorders considered as primary esophageal motility disorders, a disease category exists, which shows eosinophilic infiltration in the esophageal muscle layer with no eosinophils in the epithelium.

    DOI: 10.1111/nmo.12968

    Web of Science

    researchmap

  • Immunohistochemical differentiation of eosinophilic esophageal myositis from eosinophilic esophagitis 査読

    Hiroki Sato, Nao Nakajima, Go Hasegawa, Yuzo Kawata, Yuichi Sato, Kenji Suzuki, Terasu Honma, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 ( 1 )   106 - 113   2017年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Background and AimEosinophilic esophagitis (EoE) is a Th2-mediated allergic disease of the esophageal epithelium, associated with antigen. We previously reported a case series for eosinophilic esophageal myositis (EoEM)a novel eosinophilic gastrointestinal disorder defined as eosinophilic infiltration localized in the esophageal muscle layerand diagnosed it by peroral endoscopic muscle biopsy. Here, we investigated the immunopathology of EoEM to differentiate it from EoE.
    MethodsHistological analysis was performed for three cases of EoEM and EoE, respectively. The results were compared with those of two control samples (non-eosinophilic gastrointestinal disorder full-layer esophagus). Using immunofluorescence, we analyzed the expression of the chemokine receptor CCR3 and its ligands eotaxin-1 and eotaxin-3 to investigate the eosinophilic reaction. Additionally, we determined the expression patterns of desmoglein-1 in the esophageal epithelium, which shows dysregulated expression in EoE.
    ResultsEosinophil infiltration was observed in the muscle layer (maximum number, 30, 36, 73/high-power field) and the epithelium (50, 44, 40/high-power field) for EoEM and EoE, respectively. In EoE esophageal epithelium, the number of eotaxin-3-positive epithelial cells was significantly increased together with CCR3-positive infiltrating cells. However, in EoEM, a number of eotaxin-1-positive and eotaxin-3-positive myocytes and vascular endothelial cells were increased in the esophageal muscle layer. A significant loss of desmoglein-1 expression was only observed in EoE, not in EoEM.
    ConclusionsEotaxin-1 and eotaxin-3 expression on the smooth muscle and vessels plays a role in the pathogenesis of EoEM, while EoE shows an epithelial eotaxin-3-dominant immunoreaction. Thus, the EoEM immunological pattern displays clear differences from that of EoE.

    DOI: 10.1111/jgh.13466

    Web of Science

    PubMed

    researchmap

  • A case of hepatic inflammatory pseudo-tumor of the liver mimicking a metastatic tumor of colon and/or bile duct cancer 査読

    Masayoshi Ko, Toru Ishikawa, Michitaka Imai, Hiroki Sato, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Hiroshi Ogawa, Toshihiro Tsubono, Takeo Nemoto, Keiko Takeda, Ken Nishikura, Noriko Ishihara, Toshiaki Yoshida, Tomoteru Kamimura

    Acta Hepatologica Japonica   58 ( 4 )   241 - 247   2017年

     詳細を見る

    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Society of Hepatology  

    The patient was a 71-year-old-male, who had history of extrahepatic bile duct resection for bile duct cancer. Abdominal CT revealed two low density areas in S5 and S6. EOB-MRI revealed multiple masses in both lobes of liver, which were a hypointensity in the hepatobiliary phase. Imaging modalities suggested that these masses were metastatic liver tumor. However, we could not diagnose the primary lesion of this liver tumor. We performed percutaneous needle biopsy of the liver tumor to clarify the primary lesion. Histopathogical examination for tumor biopsy specimen confirmed no evidence of malignant change, and revealed remarkable fibrosis with scattered chronic inflammatory cell infiltration. Moreover, histological findings of the liver around the tumor lesion showed inflammatory cell infiltration, fibrosis and ductural proliferation in the portal area that reflect chronic cholangitis. Hepatic inflammatory pseudo-tumor as a sequel of chronic cholangitis is a rare condition.

    DOI: 10.2957/kanzo.58.241

    Scopus

    researchmap

  • A novel training model composed of nonbiological materials for endoscopic submucosal dissection. 査読

    Mizuno K, Sato H, Hashimoto S, Sato Y, Terai S

    Gastrointestinal endoscopy   84 ( 2 )   373 - 374   2016年8月

     詳細を見る

  • Assessments of histologic changes after peroral endoscopic myotomy. 査読

    Sato H, Sagara S, Suzuki K, Terai S, Yahagi N

    Gastrointestinal endoscopy   84 ( 2 )   377 - 378   2016年8月

  • Gastrointestinal: Salvage peroral endoscopic myotomy for outflow obstruction with growing esophageal diverticulum 査読

    H. Sato, Y. Sato, S. Hashimoto, K. Mizuno, N. Nakajima, S. Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31 ( 7 )   1237 - 1237   2016年7月

     詳細を見る

    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/jgh.13397

    Web of Science

    researchmap

  • Novel ex-vivo training model for peroral endoscopic myotomy using hydrogel 査読

    Hiroki Sato, Ken-ichi Mizuno, Shuji Terai

    DIGESTIVE ENDOSCOPY   28 ( 5 )   620 - 620   2016年7月

     詳細を見る

    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/den.12670

    Web of Science

    PubMed

    researchmap

  • An Unusual Case of an Esophageal Functional Disorder 査読

    Kazuya Takahashi, Hiroki Sato, Yuichi Sato

    GASTROENTEROLOGY   149 ( 6 )   E15 - E16   2015年11月

     詳細を見る

    記述言語:英語   出版者・発行元:W B SAUNDERS CO-ELSEVIER INC  

    DOI: 10.1053/j.gastro.2014.10.051

    Web of Science

    PubMed

    researchmap

  • Nutcracker and jackhammer esophagus treatment: a three-case survey, including two novel cases of eosinophilic infiltration into the muscularis propria 査読

    Hiroki Sato, Manabu Takeuchi, Kazuya Takahashi, Yuichi Sato, Satoru Hashimoto, Kenichi Mizuno, Kenji Suzuki, Masaaki Kobayashi, Terasu Honma, Haruhiro Inoue, Shuji Terai

    ENDOSCOPY   47 ( 9 )   855 - 857   2015年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:GEORG THIEME VERLAG KG  

    Nutcracker esophagus and jackhammer esophagus are largely unknown motility disorders, also sometimes called hypertensive and hypercontractile peristalsis, respectively. There is currently no standardized diagnostic or management plan for these diseases. Here, we report on three patients with jackhammer/nutcracker esophagus who were treated with either peroral endoscopic myotomy or a systemic steroid regimen, focusing particularly on two novel presentations of nutcracker and jackhammer esophagus involving eosinophilic infiltration into the muscularis propria, and their responses to both interventions.

    DOI: 10.1055/s-0034-1391985

    Web of Science

    PubMed

    researchmap

  • Gastroenterology: A unique endoscopic technique for full-layer histology of jackhammer esophagus 査読

    H. Sato, G. Hasegawa, M. Takeuchi, K. Takahashi, Y. Sato, S. Hashimoto, K. Mizuno, M. Kobayashi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30 ( 8 )   1226 - 1226   2015年8月

     詳細を見る

    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/jgh.12914

    Web of Science

    researchmap

  • Per-Oral Endoscopic Myotomy: A Series of 500 Patients 査読

    Haruhiro Inoue, Hiroki Sato, Haruo Ikeda, Manabu Onimaru, Chiaki Sato, Hitomi Minami, Hiroshi Yokomichi, Yasutoshi Kobayashi, Kevin L. Grimes, Shin-ei Kudo

    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS   221 ( 2 )   256 - 264   2015年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND: After the first case of per-oral endoscopic myotomy (POEM) at our institution in 2008, the procedure was quickly accepted as an alternative to surgical myotomy and is now established as an excellent treatment option for achalasia. This study aimed to examine the safety and outcomes of POEM at our institution.
    STUDY DESIGN: Per-oral endoscopic myotomy was performed on 500 consecutive achalasia patients at our institution between September 2008 and November 2013. A review of prospectively collected data was conducted, including procedure time, myotomy location and length, adverse events, and patient data with short- (2 months) and long-term (1 and 3 years) follow-up.
    RESULTS: Per-oral endoscopic myotomy was successfully completed in all patients, with adverse events observed in 3.2%. Two months post-POEM, significant reductions in symptom scores (Eckardt score 6.0 +/- 3.0 vs 1.0 +/- 2.0, p &lt; 0.0001) and lower esophageal sphincter (LES) pressures (25.4 +/- 17.1 vs 13.4 +/- 5.9 mmHg, p &lt; 0.0001) were achieved, and this persisted at 3 years post-POEM. Gastroesophageal reflux was seen in 16.8% of patients at 2 months and 21.3% at 3-year follow-up.
    CONCLUSIONS: Per-oral endoscopic myotomy was successfully completed in all cases, even when extended indications (extremes of age, previous interventions, or sigmoid esophagus) were used. Adverse events were rare (3.2%), and there were no mortalities. Significant improvements in Eckardt scores and LES pressures were seen at 2 months, 1 year, and 3 years post-POEM. Based on our large series, POEM is a safe and effective treatment for achalasia; there are relatively few contraindications, and the procedure may be used as either first-or second-line therapy. (C) 2015 by the American College of Surgeons

    DOI: 10.1016/j.jamcollsurg.2015.03.057

    Web of Science

    PubMed

    researchmap

  • Gastroenterology: Histopathological investigation of distal esophageal spasm (DES) using per-oral endoscopic myotomy (POEM) 査読

    K. Takahashi, H. Sato, Y. Sato, M. Takeuchi, S-R Takeda, K. Mizuno, S. Hashimoto, G. Hasegawa, M. Kobayashi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30 ( 7 )   1113 - 1113   2015年7月

     詳細を見る

    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/jgh.12926

    Web of Science

    researchmap

  • In vivo histopathology using endocytoscopy for non-neoplastic changes in the gastric mucosa: a prospective pilot study (with video). 査読

    Sato H, Inoue H, Hayee B, Ikeda H, Sato C, Phalanusitthepha C, Santi EG, Kobayashi Y, Kudo SE

    Gastrointestinal endoscopy   81 ( 4 )   875 - 881   2015年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.gie.2014.08.019

    Web of Science

    PubMed

    researchmap

  • In vivo gastric mucosal histopathology using endocytoscopy 査読

    Hiroki Sato, Haruhiro Inoue, Haruo Ikeda, Chiaki Sato, Chainarong Phlanusittepha, Bu'Hussain Hayee, Esperanza Grace R. Santi, Yasutoshi Kobayashi, Shin-ei Kudo

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 16 )   5002 - 5008   2015年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BAISHIDENG PUBLISHING GROUP INC  

    AIM: To study the ability of endocytoscopy to identify normal gastric mucosa and to exclude Helicobacter pylori (H. pylori) infection.
    METHODS: Endocytoscopic examination of the gastric corpus and antrum was performed in 70 consecutive patients. Target biopsy specimens were also obtained from the assessed region and multiple H. pylori tests were performed. The normal endocytoscopy patterns of the corpus and antrum were divided into the normal pit-dominant type (n-Pit) or the normal papilla-dominant type (n-Pap), respectively characterized as either regular pits with capillary networks or round, smooth papillary structures with spiral capillaries. On the other hand, normal mucosa was defined as mucosa not demonstrating histological abnormalities, including inflammation and atrophy.
    RESULTS: The sensitivity and specificity of n-Pit for normal mucosa in the gastric corpus were 94.4% and 97.1%, respectively, whereas those of n-Pap for normal mucosa in the antrum were 92.0% and 86.7%, respectively. The positive predictive values of n-Pit and n-Pap for H. pylori-negative tissue were 88.6% and 93.1%, respectively, and their negative predictive values for H. pylori-negative tissues were 42.9% and 41.5%, respectively. The inter-observer agreement for determining n-Pit and n-Pap for normal mucosa were 0.857 and 0.769, respectively, which is considered reliable.
    CONCLUSION: N-Pit and n-Pap, seen using EC, are considered useful predictors of normal mucosa and the absence of H. pylori infection.

    DOI: 10.3748/wjg.v21.i16.5002

    Web of Science

    PubMed

    researchmap

  • Eosinophilic Infiltration of the Muscularis Propria in a Patient With Jackhammer Esophagus Treated With Per-Oral Endoscopic Myotomy 査読

    Hiroki Sato, Manabu Takeuchi, Kazuya Takahashi

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   13 ( 4 )   E33 - E34   2015年4月

     詳細を見る

    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    DOI: 10.1016/j.cgh.2014.11.005

    Web of Science

    PubMed

    researchmap

  • Utility of intrapapillary capillary loops seen on magnifying narrow-band imaging in estimating invasive depth of esophageal squamous cell carcinoma 査読

    Hiroki Sato, Haruhiro Inoue, Haruo Ikeda, Chiaki Sato, Manabu Onimaru, BuHussain Hayee, Chainarong Phlanusi, Esperanza Grace R. Santi, Yasutoshi Kobayashi, Shin-ei Kudo

    ENDOSCOPY   47 ( 2 )   122 - 128   2015年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:GEORG THIEME VERLAG KG  

    Background and study aims: Intrapapillary capillary loops (IPCLs) have been used to estimate histopathological atypia and the invasion depth of squamous cell carcinoma (SCC). The aim of this study was to evaluate the clinical significance of IPCLs.
    Patients and methods: A total of 358 consecutive patients with esophageal neoplasia on magnifying narrow-band imaging (M-NBI) were studied. The lesions were categorized according to the IPCL classification of Inoue et al. and were subsequently resected. Resected specimens were histopathologically analyzed to determine the invasion depth. The inter-and intraobserver agreements in the interpretation of IPCL images were also investigated.
    Results: A total of 446 lesions were diagnosed on M-NBI as IPCL type V lesions, which were further classified as 185 IPCL type V1, 109 type V2, 104 type V3, and 48 type Vn. Sensitivity and specificity of IPCL type V1-2 for invasion confined to the epithelium or lamina propria mucosa (m1-2) were 89.5% (95% confidence interval [CI] 85.4%92.7 %) and 79.6% (95 % CI 72.3%-85.7 %), respectively. Sensitivity and specificity of IPCL type V3 for invasion confined to the muscularis mucosa or slight submucosal invasion (m3-sm1) were 58.7% and 83.8 %, respectively. Sensitivity and specificity of IPCL type Vn for deeper invasion (sm2-3) were 55.8% and 98.6 %, respectively. Interobserver agreement was substantial (kappa=0.609, 0.641, and 0.705), as was intraobserver agreement (kappa=0.705 and kappa=0.819).
    Conclusion: Changes in the morphology of IPCLs on M-NBI correlated with the depth of SCC invasion, and results were reproducible and reliable among observers. Identification of IPCL type V1-2 proved useful for the intraprocedural identification of m1-2 lesions, which are considered an absolute indication for endoscopic resection.

    DOI: 10.1055/s-0034-1390858

    Web of Science

    PubMed

    researchmap

  • Salvage peroral endoscopic myotomy for esophageal diverticulum 査読

    Hiroki Sato, Yuichi Sato, Manabu Takeuchi, Kazuya Takahashi, Shin-ryu Takeda, Haruhiro Inoue, Masaaki Kobayashi

    ENDOSCOPY   47   E14 - E15   2015年

     詳細を見る

    記述言語:英語   出版者・発行元:GEORG THIEME VERLAG KG  

    DOI: 10.1055/s-0034-1390735

    Web of Science

    PubMed

    researchmap

  • Epiphrenic diverticulum of the esophagus after peroral endoscopic myotomy 査読

    Hiroki Sato, Kazuya Takahashi, Manabu Takeuchi, Yuichi Sato, Satoru Hashimoto, Kenichi Mizuno, Shuji Terai

    ENDOSCOPY   47   E509 - E510   2015年

     詳細を見る

    記述言語:英語   出版者・発行元:GEORG THIEME VERLAG KG  

    DOI: 10.1055/s-0034-1393232

    Web of Science

    PubMed

    researchmap

  • Clinical experience of esophageal perforation occurring with endoscopic submucosal dissection 査読

    H. Sato, H. Inoue, H. Ikeda, E. Grace, R. Santi, A. Yoshida, M. Onimaru, S. Kudo

    DISEASES OF THE ESOPHAGUS   27 ( 7 )   617 - 622   2014年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Esophageal perforation occurring during or after endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) is a rare, but serious complication. However, reports of its characteristics, including endoscopic imaging and management, have not been fully detailed. To analyze and report the clinical presentation and management of esophageal perforations occurred during or after EMR/ESD. Four hundred seventy-two esophageal neoplasms in 368 patients were treated (171 EMR; ESD 306) at Northern Yokohama Hospital from 2003 to 2012. Esophageal perforation occurred in a total of seven (1.9%) patients, all of whom were male and had undergone ESD. The etiology of perforation was: three (42.9%) intraoperative; three (42.9%) balloon dilatation for stricture prevention; one (14.2%) due to food bolus impaction. All cases were managed non-operatively based on the comprehensive assessment of clinical severity, extent of the injury, and the time interval from perforation to treatment onset. Conservative management included (i) bed rest and continuous monitoring to determine the need for operative intervention; (ii) fasting and intravenous fluid infusion/tube feeding; and (iii) intravenous antibiotics. All defects closed spontaneously, save one case where closure was achieved by endoscopic clipping. Surgery was not required. Conservative management for esophageal perforation during advanced endoscopic resection is may be possible when there is no delay in diagnosis or treatment. Decision-making should be governed purely by multidisciplinary discussion.

    DOI: 10.1111/dote.12125

    Web of Science

    researchmap

  • In vivo histopathological assessment of the muscularis propria in achalasia by using endocytoscopy (with video). 査読

    Sato H, Inoue H, Ikeda H, Sato C, Santi EG, Phalanusitthepha C, Aoyagi Y, Kudo SE

    Endoscopy international open   2 ( 3 )   E178 - 82   2014年9月

  • Magnification narrow-band imaging for the diagnosis of early gastric cancer: A review of the Japanese literature for the Western endoscopist 査読

    Bu'Hussain Hayee, Haruhiro Inoue, Hiroki Sato, Esperanza Grace Santi, Akira Yoshida, Manabu Onimaru, Haruo Ikeda, Shin-Ei Kudo

    Gastrointestinal Endoscopy   78 ( 3 )   452 - 461   2013年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.gie.2013.03.1333

    Scopus

    PubMed

    researchmap

  • Control of severe strictures after circumferential endoscopic submucosal dissection for esophageal carcinoma: oral steroid therapy with balloon dilation or balloon dilation alone 査読

    Hiroki Sato, Haruhiro Inoue, Yasutoshi Kobayashi, Roberta Maselli, Esperanza Grace R. Santi, Bu'Hussain Hayee, Kenta Igarashi, Akira Yoshida, Haruo Ikeda, Manabu Onimaru, Yutaka Aoyagi, Shin-ei Kudo

    GASTROINTESTINAL ENDOSCOPY   78 ( 2 )   250 - 257   2013年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MOSBY-ELSEVIER  

    Background: Recent technological advances have allowed superficially spreading intramucosal carcinomas of the esophagus to be successfully resected by circumferential endoscopic submucosal dissection (cESD). After this procedure, esophageal strictures develop in most patients and are mainly treated by endoscopic balloon dilation (EBD).
    Objective: To compare oral steroids plus EBD with EBD alone for the management of benign esophageal strictures after cESD.
    Design: Retrospective cohort study.
    Setting: Tertiary-care referral center.
    Patients: We studied 23 consecutive patients who underwent complete cESD for superficial esophageal carcinoma (22 squamous cell carcinomas and 1 adenocarcinoma associated with Barrett's esophagus).
    Intervention: After cESD, patients were managed with EBD alone (EBD, n = 13) or with EBD and oral prednisolone (steroid + EBD, n = 10), 30 mg daily, started 2 days after cESD and gradually tapered and discontinued after 8 weeks.
    Main Outcome Measurements: Total number of EBD sessions and total EBD period (months).
    Results: Steroid + EBD patients required fewer sessions (13.8 +/- 6.9 vs 33.5 +/- 22.9; P &lt; .001) and a shorter management period (4.8 +/- 2.3 vs 14.2 +/- 17.5 months, P &lt; .005) compared with the EBD group. An additional 3 patients received oral steroids a mean interval of 158 days after cESD. These patients required more EBD sessions (46.3 +/- 30.0; P = .002), and the EBD period was significantly longer (17.5 +/- 13.0 months; P = .005) than in the early steroid + EBD group.
    Limitations: Nonrandomized study; retrospective analysis.
    Conclusion: After cESD, oral steroid therapy dramatically reduced the need for EBD. We conclude that oral steroid therapy after EBD is an effective strategy for the management of esophageal strictures after complete cESD.

    DOI: 10.1016/j.gie.2013.01.008

    Web of Science

    PubMed

    researchmap

  • Diagnostic Technique: In Vivo Diagnosis of Cellular Atypia Using Endocytoscope: EC Classification in Squamous Epithelium 査読

    H. Inoue, H. Ikeda, A. Yoshida, M. Onimaru, H. Sato, S. Kudo

    Video Journal and Encyclopedia of GI Endoscopy   1 ( 1 )   16 - 17   2013年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Endocytoscopy enables us to observe cellular nucleus in vivo in the squamous esophagus and pharynx. Endocytoscopy is a contact endoscopy with 340-1100-fold magnification. Topical spray of crystal violet and methylene blue solution creates a well-contrasted image which is similar to hematoxylin and eosin staining. Endocytoscopic findings of tissue atypia are summarized in endocytoscopic (EC) classification. EC-1 is nonneoplastic, which includes normal (EC-1a) and inflammatory or reactive (EC-1b). EC-2 is a borderline lesion. EC-3 is a cancerous image, often with increased cellularity and with enlarged and polymorphic nuclei. This article is part of an expert video encyclopedia. © 2013 Elsevier GmbH.

    DOI: 10.1016/S2212-0971(13)70008-6

    Scopus

    researchmap

▶ 全件表示

書籍等出版物

  • 好酸球性食道炎 -疾患概念から治療の最前線-

    佐藤 裕樹, 水野 研一, 橋本 哲, 横山 純二, 本間 照, 寺井 崇二

    消化器内科 (医学出版社)  2020年6月 

     詳細を見る

  • 食道良性腫瘍および腫瘍様病変の診断 食道壁内偽憩室症

    橋本 哲, 水野 研一, 佐藤 裕樹

    胃と腸 第55巻 第3号 (医学書院)  2020年3月 

     詳細を見る

  • 佐藤 裕樹. 実臨床における難治性消化管運動異常症の病態解析と新規内視鏡治療法の臨床応用

    佐藤 裕樹

    新潟県医師会報  2019年12月 

     詳細を見る

  • 好酸球関連消化管疾患-好酸球関連消化管疾患の最新の話題-

    佐藤 裕樹, 水野 研一, 橋本 哲, 横山 純二, 本間 照, 寺井 崇二

    消化器・肝臓内科 第6巻第2号  2019年8月 

     詳細を見る

MISC

  • 食道アカラシアの診断と治療戦略 経口内視鏡的筋層切開術(POEM)後に生じる逆流性食道炎の検討

    高橋 一也, 佐藤 裕樹, 冨永 顕太郎, 河久 順志, 五十嵐 聡, 林 和直, 水野 研一, 橋本 哲, 横山 純二, 寺井 崇二

    日本消化管学会雑誌   2 ( Suppl. )   135 - 135   2018年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

    researchmap

  • Long-Term Outcome of Endoscopic Submucosal Dissection in Esophageal Squamous Cell Carcinoma Invading Into the Muscularis Mucosa or Submucosa Up to 200 mu m

    Kazuya Takahashi, Satoru Hashimoto, Kenichi Mizuno, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB108 - AB108   2017年5月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MOSBY-ELSEVIER  

    Web of Science

    researchmap

  • Feasibility of Endogel (TM) Simulation Training for Per-Oral Endoscopic Myotomy (POEM): First United Kingdom Experience

    Shraddha Gulati, Andrew Emmanuel, Haruhiro Inoue, Ken-ichi Mizuno, Hiroki Sato, Shuji Terai, Amyn Haji, Bu Hayee

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB152 - AB153   2017年5月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MOSBY-ELSEVIER  

    Web of Science

    researchmap

  • 粘膜,粘膜下層,さらに筋層の時代へ~Minimally Invasive Treatmentの新たな潮流~〔粘膜下層に対するアプローチ〕Submucosal endoscopyによる筋層生検—経口内視鏡的食道筋層生検術(POEM‐b)による新しい知見—

    佐藤裕樹, 佐藤裕樹, 高橋一也, 中島尚, 水野研一, 橋本哲, 五十嵐聡, 林和直, 本田穣, 横山純二, 佐藤祐一, 本間照, 寺井崇二

    消化器内視鏡   29 ( 2 )   273‐277   2017年2月

     詳細を見る

    記述言語:日本語  

    J-GLOBAL

    researchmap

  • A novel training model made of polyvinyl alcohol hydrogel for endoscopic submucosal dissection

    Ken-Chi Mizuno, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Satoru Hashimoto, Junji Yokoyama, Yuichi Sato, Shuji Terai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   277 - 278   2016年11月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

    Web of Science

    researchmap

  • Assessments of histologic changes after peroral endoscopic myotomy

    Hiroki Sato, Seiji Sagara, Kenji Suzuki, Shuji Terai, Naohisa Yahagi

    GASTROINTESTINAL ENDOSCOPY   84 ( 2 )   377 - 378   2016年8月

     詳細を見る

    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

    DOI: 10.1016/j.gie.2016.01.011

    Web of Science

    researchmap

  • 当科における門脈圧亢進症を伴った骨髄増殖性疾患症例の予後に関する検討

    清野 智, 川合 弘一, 横尾 健, 佐藤 裕樹, 本田 穣, 兼藤 努, 上村 博輝, 上村 顕也, 土屋 淳紀, 高村 昌昭, 山際 訓, 須田 剛士, 野本 実, 寺井 崇二, 増子 正義, 田中 研介, 柳 雅彦, 佐藤 直子, 矢野 敏雄

    新潟医学会雑誌   129 ( 10 )   631 - 632   2015年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:新潟医学会  

    researchmap

  • Does an Endoscopic Submucosal Dissection Scar Affect Esophageal Motility?

    Kazuya Takahashi, Manabu Takeuchi, Yuichi Sato, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Shin-ryu Takeda, Masaaki Kobayashi, Shuji Terai

    GASTROENTEROLOGY   148 ( 4 )   S807 - S807   2015年4月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:W B SAUNDERS CO-ELSEVIER INC  

    Web of Science

    researchmap

  • Peroral Enodoscopic Myotomy (POEM) for esophageal achalasia: Results in 200 patients

    Roberta Maselli, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Esperanza Grace Santi, Hiroki Sato, Shin-Ei Kudo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   27   120 - 120   2012年12月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

    Web of Science

    researchmap

  • Endoscopic treatment for esophageal achalasia with early squamous cell carcinoma: POEM plus ESD

    Esperanza Grace Santi, Haruhiro Inoue, Hiroki Sato, Roberta Maselli, Haruo Ikeda, Akira Yoshida, Manabu Onimaru, Shin-Ei Kudo

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   27   317 - 318   2012年12月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

    Web of Science

    researchmap

  • 診断に苦慮し急速な肝不全の進行を来たした肝アミロイドーシスの1例

    星隆洋, 田村康, 佐藤裕樹, 横山純二, 山際訓, 青柳豊, 丸山弦, 大矢洋, 森山雅人, 後藤眞

    新潟医学会雑誌   126 ( 11 )   628   2012年11月

     詳細を見る

    記述言語:日本語  

    J-GLOBAL

    researchmap

▶ 全件表示

共同研究・競争的資金等の研究

  • 診断困難な消化管運動異常症と機能性消化管疾患との境界症例の病態解明

    研究課題/領域番号:20K08279  2020年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    佐藤 裕樹, 寺井 崇二, 上村 顕也, 浜本 義彦, 横道 洋司

      詳細を見る

    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

    researchmap

  • 口腔ピロリ菌の闇に迫るー分離・同定,感染機序,持続感染制御因子の探索的研究

    2019年6月 - 2021年3月

    文部科学省  科学研究費助成金 挑戦的研究(萌芽) 

    野杁 由一郎

      詳細を見る

    資金種別:競争的資金

    researchmap

  • 小腸絨毛基底膜における「窓」の脂肪吸収に対する調節機能の解明

    研究課題/領域番号:19K08462  2019年4月 - 2022年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    横山 純二, 寺井 崇二, 牛木 辰男, 高村 昌昭, 八木 一芳, 冨永 顕太郎, 佐藤 裕樹

      詳細を見る

    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

    researchmap

  • 間葉系幹細胞およびコラゲナーゼを用いた難治性食道狭窄に対する治療法の開発

    2019年4月 - 2022年3月

    文部科学省  科学研究費補助金(基盤研究(C)) 

    橋本 哲

      詳細を見る

    資金種別:競争的資金

    researchmap

  • 内視鏡医学研究振興財団 2019年度研究助成B

    2019年2月

    内視鏡医学研究振興財団 

    佐藤 裕樹

      詳細を見る

    担当区分:研究代表者 

    researchmap

  • 運動機能解析と組織病理解析の併用による消化管運動異常症の包括的病態解明

    2018年4月 - 2020年3月

    文部科学省: 科学研究費補助金(若手研究) 

    佐藤 裕樹

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

    researchmap

  • 内視鏡的食道筋層生検法による好酸球性食道筋炎の疾患概念確立と病態解明

    2016年4月 - 2019年3月

    文部科学省: 科学研究費補助金(若手研究(B)) 

    佐藤 裕樹

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

    researchmap

  • 生体吸収性ハイドロゲルシートを用いた内視鏡的粘膜下層剥離術後食道狭窄予防法の開発

    2016年4月 - 2019年3月

    文部科学省: 科学研究費補助金(基盤研究(C)) 

    橋本 哲

      詳細を見る

    資金種別:競争的資金

    researchmap

  • 新しい疾患カテゴリー『好酸球性食道筋炎』の病態解明

    2015年4月 - 2016年3月

    塚田医学奨学金 

    佐藤 裕樹

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

    researchmap

  • 好酸球性食道筋炎の病態解明

    2015年

    武田科学振興財団助成金  医学系研究奨励 

    佐藤 裕樹

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

    researchmap

▶ 全件表示