Faculty Profiles - IKARASHI Satoshi

写真a

IKARASHI Satoshi

Organization

Graduate School of Medical and Dental Sciences Specially Appointed Associate Professor

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Degree

医学博士 ( 2012.9 新潟大学 )

Research Areas

Life Science / Gastroenterology

Research History

Niigata University Graduate School of Medical and Dental Sciences Specially Appointed Associate Professor

2022.6
Niigata University University Medical and Dental Hospital Gastroenterology Assistant Professor

2018.8 - 2022.5

Papers

Coexistence of Relapsing Polychondritis, Crohn's Disease, and Pyoderma Gangrenosum Treated Successfully with Adalimumab: A Case Report and Literature Review.

Shun Yamazaki, Kentaro Tominaga, Kotaro Watanabe, Makoto Watanabe, Shuhei Kondo, Norihiro Sakai, Tomoaki Yoshida, Yuichi Kojima, Yusuke Watanabe, Yuzo Kawata, Naruhiro Kimura, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Hiroteru Kamimura, Kazunao Hayashi, Shuji Terai

Internal medicine (Tokyo, Japan) 2025.3

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Relapsing polychondritis (RP) is a rare, progressive, immune-mediated systemic inflammatory disease of unknown etiology characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with autoimmune disease. However, co-occurrence of RP and Crohn's disease (CD) has rarely been reported. We herein report a case of coexisting RP, CD, and pyoderma gangrenosum that was successfully treated with adalimumab in combination with methotrexate. We believe that this case and literature review will facilitate the accurate and prompt diagnosis and treatment of RP combined with CD and various other complications.

DOI： 10.2169/internalmedicine.5024-24

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Extremely Rare Isolated Small-Intestinal Polyp Diagnosed by Double-Balloon Endoscopy in an Asymptomatic Adult Patient. International journal

Kentaro Tominaga, Annenkov Alexey, Yuto Tanaka, Osamu Shibata, Yuichi Kojima, Yuzo Kawata, Nao Nakajima, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Shuji Terai

Clinical case reports 13 ( 3 ) e70255 2025.3

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We present the first reported case of an isolated small-bowel intestinal juvenile polyp in an adult. This case is particularly noteworthy as it was asymptomatic, detected via computed tomography, localized by capsule endoscopy, and successfully resected via double-balloon endoscopy before the development of acute symptoms.

DOI： 10.1002/ccr3.70255

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Diffuse Large B-cell Lymphoma with Severe Lactic Acidosis and Liver Failure: A Case Report and Literature Review.

Shun Yamazaki, Yusuke Watanabe, Kazuya Takahashi, Kentaro Tominaga, Satoshi Ikarashi, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, Shuji Terai

Internal medicine (Tokyo, Japan) 2024.10

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Among causes of liver failure, liver failure due to lymphocytic infiltration is rare. Unlike typical liver failure, some cases present with severe lactic acidosis and a poor prognosis. We herein report a case of diffuse large B-cell lymphoma with severe lactic acidosis and liver failure. We further discuss the characteristics of similar cases in the literature, suggesting that intrahepatic infiltration by hematological malignant cells should be considered as a differential diagnosis in the presence of severe lactic acidosis and liver failure. This study underscores the importance of early recognition and serves as a reference for future cases.

DOI： 10.2169/internalmedicine.4450-24

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治療困難胆管結石に対する経口胆道鏡下治療の有用性

五十嵐聡, 林和直, 柴田理, 寺井崇二

Gastroenterological Endoscopy 66 ( Suppl.2 ) 2301 - 2301 2024.10

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非切除肝門部領域胆管癌に対する内視鏡的胆管ステント留置術の検討

林和直, 柴田理, 五十嵐聡, 寺井崇二

Gastroenterological Endoscopy 66 ( Suppl.2 ) 2292 - 2292 2024.10

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「長期臨床経過を見据えた消化器疾患の治療・管理における工夫と課題」自己免疫性膵炎のステロイド治療導入後再燃例における臨床経過の検証

田中裕登, 柴田理, 五十嵐聡, 林和直, 寺井崇二

日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集 75回・97回 51 - 51 2024.10

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治療困難胆管結石に対する経口胆道鏡下治療の有用性

五十嵐聡, 林和直, 柴田理, 寺井崇二

Gastroenterological Endoscopy 66 ( Suppl.2 ) 2301 - 2301 2024.10

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非切除肝門部領域胆管癌に対する内視鏡的胆管ステント留置術の検討

林和直, 柴田理, 五十嵐聡, 寺井崇二

Gastroenterological Endoscopy 66 ( Suppl.2 ) 2292 - 2292 2024.10

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胆膵内視鏡検査・治療における工夫とトラブルシューティング当院における副乳頭アプローチカニュレーション

名古屋拓郎, 小川光平, 五十嵐聡, 林和直, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 39 ( 2 ) 154 - 154 2024.6

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IgG4関連疾患における診断・治療困難例に対する取り組み自己免疫性膵炎のステロイド治療導入後再燃例における臨床経過の検証

小川光平, 名古屋拓郎, 五十嵐聡, 林和直, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 39 ( 2 ) 148 - 148 2024.6

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胆膵内視鏡検査・治療における工夫とトラブルシューティング当院における副乳頭アプローチカニュレーション

名古屋拓郎, 小川光平, 五十嵐聡, 林和直, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 39 ( 2 ) 154 - 154 2024.6

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IgG4関連疾患における診断・治療困難例に対する取り組み自己免疫性膵炎のステロイド治療導入後再燃例における臨床経過の検証

小川光平, 名古屋拓郎, 五十嵐聡, 林和直, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 39 ( 2 ) 148 - 148 2024.6

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Portal biliopathyにより胆管消失症候群を来したと考えられる一例

木村究, 上村博輝, 渡邉雄介, 五十嵐聡, 土屋淳紀, 寺井崇二, 佐久間康成, 大西康晴, 眞田幸弘, 脇屋太一, 平田雄大, 大豆生田尚彦

肝臓 65 ( Suppl.1 ) A301 - A301 2024.4

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当院における慢性膵炎に伴う膵仮性嚢胞の合併症治療

林和直, 五十嵐聡, 寺井崇二

日本消化器病学会雑誌 121 ( 臨増総会 ) A334 - A334 2024.3

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EUS-FNAが診断に有用であった原発性舌下腺癌に合併した多発膵腫瘍の1例

渡邊誠, 五十嵐聡, 渡邊浩太朗, 山崎駿, 酒井規裕, 渡邉雄介, 冨永顕太郎, 高橋一也, 上村博輝, 寺井崇二

日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集 73回・95回 68 - 68 2023.11

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重症急性膵炎後Walled-off necrosisの内視鏡治療における最適なステントの選択

五十嵐聡, 林和直, 寺井崇二

Gastroenterological Endoscopy 65 ( Suppl.2 ) 2046 - 2046 2023.10

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高齢者の術後再建腸管結石例に対するダブルバルーン内視鏡下ERCPの検討

林和直, 五十嵐聡, 寺井崇二

Gastroenterological Endoscopy 65 ( Suppl.2 ) 2022 - 2022 2023.10

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Similarity of oncogenic protein expression in KRASG12D gene delivery-based rat pancreatic cancer model to that of human pancreatic cancer. International journal

Yuto Tanaka, Kenya Kamimura, Osamu Shibata, Kohei Ogawa, Chiyumi Oda, Hiroyuki Abe, Satoshi Ikarashi, Kazunao Hayashi, Takeshi Yokoo, Toshifumi Wakai, Shuji Terai

Biochemical and biophysical research communications 673 29 - 35 2023.9

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BACKGROUND: The development of effective therapies and biomarkers for pancreatic cancer is an unmet clinical need. To address this, we have developed an easy-to-use pancreatic cancer rat animal model via pancreas-targeted hydrodynamic gene delivery of human pancreatic cancer-related genes. Our study aimed to determine the molecular similarity between the pancreatic tumor in the rat model and human pancreatic cancer. METHODS: KRASG12D gene-expressing plasmid was delivered to the pancreas of wild type rats via pancreas-targeted hydrodynamic gene delivery as previously reported. Tissue samples were collected at 5 weeks after the first gene delivery. The tumors developed in the rats were assessed for the expression of oncogenic proteins that are involved in human pancreatic cancer development. RESULTS: The development of a tumor mimicking pancreatic ductal adenocarcinoma was confirmed. The expression levels of Cyclin D1, c-Jun, IL-33, and Zip4 proteins in the tumor were immunohistochemically assessed and the correlation of the proteins was confirmed. The expression pattern showed similarity to that of surgically resected human pancreatic cancer tissues. CONCLUSIONS: Our study findings showing a similar pattern of oncogenic protein expression in novel KRASG12D gene-induced rat pancreatic cancer model and human pancreatic cancer will be useful for establishing novel tumor markers and therapeutic options for pancreatic cancer.

DOI： 10.1016/j.bbrc.2023.06.057

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消化器病に対する低侵襲治療切除不能肝内胆管癌に対して肝動脈化学塞栓療法(TACE)および重粒子線治療を行った1例

内山敦司, 上村博輝, 木村莉菓, 佐藤千紘, 木村究, 渡邉雄介, 高橋一也, 五十嵐聡, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 39 ( 1 ) 37 - 37 2023.9

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胆膵内視鏡検査・治療における工夫とトラブルシューティング当院における副乳頭アプローチカニュレーション

名古屋拓郎, 小川光平, 五十嵐聡, 林和直, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 72回 48 - 48 2023.6

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IgG4関連疾患における診断・治療困難例に対する取り組み自己免疫性膵炎のステロイド治療導入後再燃例における臨床経過の検証

小川光平, 名古屋拓郎, 五十嵐聡, 林和直, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 72回 40 - 40 2023.6

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膵癌早期診断の最前線 cStage 0/I膵癌の臨床像膵癌病態解析に関する多施設後方視的観察研究の結果より

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 120 ( 臨増総会 ) A135 - A135 2023.3

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当院における膵小病変に対するEUS-FNA/Bの成績

林和直, 小川光平, 五十嵐聡, 寺井崇二

日本消化器病学会雑誌 120 ( 臨増総会 ) A375 - A375 2023.3

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術後再建腸管例の悪性胆道狭窄に対するバルーン内視鏡下胆道ドレナージの有用性

名古屋拓郎, 寺井崇二, 林和直, 五十嵐聡, 小川光平

ENDOSCOPIC FORUM for digestive disease 38 ( 2 ) 153 - 153 2022.12

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重症急性膵炎後Walled-off necrosisの内視鏡治療におけるLumen apposing metal stentの有効性

林和直, 五十嵐聡, 小川光平, 寺井崇二

Gastroenterological Endoscopy 64 ( Suppl.2 ) 2126 - 2126 2022.10

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ガイドライン改訂後の膵炎診療の現状と課題重症急性膵炎後Walled-off necrosisの経過における抗菌薬投与の影響

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 119 ( 臨増大会 ) A534 - A534 2022.10

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Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method. International journal

Osamu Shibata, Kenya Kamimura, Yuto Tanaka, Kohei Ogawa, Takashi Owaki, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Hiroyuki Abe, Satoshi Ikarashi, Kazunao Hayashi, Takeshi Yokoo, Shuji Terai

Molecular therapy. Nucleic acids 28 342 - 352 2022.6

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This research developed an easy-to-use, reproducible pancreatic cancer animal model utilizing pancreas-targeted hydrodynamic gene delivery to deliver human pancreatic cancer-related genes to the pancreas of wild-type rats. KRAS G12D -induced pancreatic intraepithelial neoplasia lesions showed malignant transformation in the main pancreatic duct at 4 weeks and developed acinar-to-ductal metaplasia, which led to pancreatic ductal adenocarcinoma within 5 weeks, and the gene combination of KRAS G12D and YAP enhanced these effects. The repeat hydrodynamic gene delivery of KRAS G12D + YAP combination at 4 weeks showed acinar-to-ductal metaplasia in all rats and pancreatic ductal adenocarcinoma in 80% of rats 1 week later. Metastatic tumors in the liver, lymph nodes, and subcutaneous lesions and nervous invasion were confirmed. KRAS G12D and YAP combined transfer contributes to the E- to N-cadherin switch in pancreatic ductal adenocarcinoma cells and to tumor metastases. This pancreatic cancer model will speed up pancreatic cancer research for novel treatments and biomarkers for early diagnosis.

DOI： 10.1016/j.omtn.2022.03.019

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悪性胆道狭窄に対する治療戦略術後再建腸管例の悪性胆道狭窄に対するバルーン内視鏡下胆道ドレナージの有用性

名古屋拓郎, 寺井崇二, 林和直, 五十嵐聡, 小川光平

日本消化器病学会甲信越支部例会抄録集 70回 np46 - np46 2022.6

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A rare case of duodenal variceal bleeding due to extrahepatic portal vein obstruction successfully treated with endoscopic injection sclerotherapy

Ashu Hori, Yusuke Watanabe, Kazuya Takahashi, Takahumi Tonouchi, Naruhiro Kimura, Toru Setsu, Satoshi Ikarashi, Hiroteru Kamimura, Junji Yokoyama, Shuji Terai

Clinical Journal of Gastroenterology 15 ( 3 ) 617 - 622 2022.4

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Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1007/s12328-022-01627-3

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Other Link： https://link.springer.com/article/10.1007/s12328-022-01627-3/fulltext.html
Methotrexate-associated proliferative disorder in the lower esophagus extending to the gastroesophageal junction: A case report. International journal

Yuki Hojo, Masafumi Takatsuna, Satoshi Ikarashi, Hiroteru Kamimura, Rika Kimura, Masaki Mito, Yusuke Watanabe, Yusuke Tani, Junji Yokoyama, Shuji Terai

DEN open 2 ( 1 ) e14 2022.4

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A 64-year-old woman was receiving oral methotrexate (MTX) for rheumatoid arthritis (RA) for 15 years. She underwent esophagogastroduodenoscopy because of discomfort in the chest. Endoscopic findings revealed an ulcer in the lower esophagus extending to the gastroesophageal junction (EGJ). The ulcer occupied half of the esophageal lumen and had a sharp and clear margin. Magnifying narrow-band imaging endoscopy revealed the deposition of white plaque, and there were few microvessels in the edge and bottom of the ulcer. Histologic examination of the biopsy specimens from the oral edge of the lesion revealed proliferation of atypical lymphoid cells (immunophenotype results: CD20 [+], CD3 [partially +], CD5 [-], and BCL-2 [-]]. The patient was diagnosed with methotrexate-associated lymphoproliferative disorder (MTX-LPD) and was advised to stop MTX intake. After 2 months of stopping MTX, the ulcer was found to be almost regressed and showed signs of healing. MTX-LPD in the lower esophagus extending to the EGJ is extremely rare. This case can help in expanding the understanding of esophageal MTX-LPD.

DOI： 10.1002/deo2.14

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Utility of autologous fecal microbiota transplantation and elucidation of microbiota in diversion colitis. International journal

Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yoshida, Yuichi Kojima, Kohei Ogawa, Yuzo Kawata, Nao Nakajima, Naruhiro Kimura, Hiroyuki Abe, Toru Setsu, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Junji Yokoyama, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Toshifumi Wakai, Shuji Terai

DEN open 2 ( 1 ) e63 2022.4

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Objectives: Diversion colitis (DC) is an inflammatory disorder caused by interruption of the fecal stream and subsequent nutrient deficiency from luminal bacteria. The utility of fecal microbiota transplantation (FMT) for DC was recently investigated; however, the precise pathogenesis of this condition remains unclear. This study aimed to evaluate the utility of autologous FMT in DC and to determine the related changes in the intestinal microbiota. Methods: Autologous FMT was performed to reestablish the intestinal microbiota in five patients (average age, 64.6 ± 8.3 years) with DC. They underwent double-ended colostomy. We assessed the diverted colon by endoscopy and evaluated the microbiota before and after FMT using the 16S rRNA gene sequencing method. Results: All five patients had mild inflammation (ulcerative colitis endoscopic index of severity [UCEIS] 2-3) in the diverted colon based on the colonoscopic findings. Three patients presented with symptoms, such as tenesmus, mucoid stool, and bloody stool. With FMT treatment, all patients achieved endoscopic remission (UCEIS score of 0 or 1) and symptomatic improvement. We observed a significantly decreased α-diversity in DC patients compared to healthy controls. The frequency of aerobic bacteria, such as Enterobacteriaceae, in the diverted colon decreased after autologous FMT. Conclusions: This study was the first to show that the microbiota in the diverted colon was significantly affected by autologous FMT. Since interruption of the fecal stream is central to the development of DC, FMT can be considered a promising treatment.

DOI： 10.1002/deo2.63

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重症急性膵炎後Walled-off necrosisの経過に対する抗菌薬投与の影響

五十嵐聡, 林和直, 寺井崇二, 小川光平

日本消化器病学会雑誌 119 ( 臨増総会 ) A344 - A344 2022.3

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脾動脈瘤破裂を契機にC型肝炎治療に至った肝硬変の1例

北條雄暉, 上村博輝, 大脇崇史, 木村莉菓, 岩澤貴宏, 渡邊雄介, 高綱将史, 五十嵐聡, 高村昌昭, 薛徹, 荒生祥尚, 堀井陽祐, 佐藤辰彦, 寺井崇二

肝臓 62 ( 11 ) 749 - 755 2021.11

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J00263&link_issn=&doc_id=20211111030008&doc_link_id=1390852945233297152&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390852945233297152&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif
脾動脈瘤破裂を契機にC型肝炎治療に至った肝硬変の1例

北條雄暉, 上村博輝, 大脇崇史, 木村莉菓, 岩澤貴宏, 渡邊雄介, 高綱将史, 五十嵐聡, 高村昌昭, 薛徹, 荒生祥尚, 堀井陽祐, 佐藤辰彦, 寺井崇二

肝臓 62 ( 11 ) 749 - 755 2021.11

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胆管への浸潤を伴う胆管内乳頭状粘液性腺癌 1症例報告(Intraductal papillary mucinous adenocarcinoma with bile duct invasion: A case report)

水戸將貴, 戸田遼, 木村究, 小島雄一, 小川光平, 木村成宏, 荒生祥尚, 五十嵐聡, 林和直, 土屋淳紀, 寺井崇二, 加藤卓, 味岡洋一, 石川博補, 滝沢一泰, 若井俊文

日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集 69回・91回 53 - 53 2021.10

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胆管への浸潤を伴う胆管内乳頭状粘液性腺癌 1症例報告(Intraductal papillary mucinous adenocarcinoma with bile duct invasion: A case report)

水戸將貴, 戸田遼, 木村究, 小島雄一, 小川光平, 木村成宏, 荒生祥尚, 五十嵐聡, 林和直, 土屋淳紀, 寺井崇二, 加藤卓, 味岡洋一, 石川博補, 滝沢一泰, 若井俊文

日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集 69回・91回 53 - 53 2021.10

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超音波内視鏡システムにおける音速補正モードの膵癌診断における有用性の検討

林和直, 小川光平, 五十嵐聡, 寺井崇二

Gastroenterological Endoscopy 63 ( Suppl.2 ) 2046 - 2046 2021.10

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Interventional EUS超音波内視鏡下瘻孔形成術の現状と問題点(膵) 重症急性膵炎後Walled-off necrosisの自然軽快に関連する因子

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 118 ( 臨増大会 ) A550 - A550 2021.10

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当院における自己免疫性膵炎およびIgG4関連硬化性胆管炎の内視鏡診断と治療

小川光平, 五十嵐聡, 林和直, 寺井崇二

Gastroenterological Endoscopy 63 ( Suppl.2 ) 2073 - 2073 2021.10

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【膵癌研究最前線】膵臓選択的ハイドロダイナミック遺伝子導入法

柴田理, 上村顕也, 田中裕登, 小川光平, 阿部寛幸, 五十嵐聡, 横尾健, 寺井崇二

消化器・肝臓内科 10 ( 3 ) 342 - 346 2021.9

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Biliary Obstruction Caused by B-Cell Lymphoma Associated With IgG4-Related Disease. International journal

Kazuya Ogawa, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Shuji Terai

The American journal of gastroenterology 2021.7

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DOI： 10.14309/ajg.0000000000001367

PubMed

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Rapid decline in visceral adipose tissue over 1 month is associated with poor prognosis in patients with unresectable pancreatic cancer. International journal

Oki Nakano, Hirokazu Kawai, Takamasa Kobayashi, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

Cancer medicine 10 ( 13 ) 4291 - 4301 2021.7

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BACKGROUND: Involuntary weight loss related to cachexia is common in patients with advanced cancer, but the association between body composition changes and survival is still unclear in pancreatic cancer. METHODS: We retrospectively reviewed the clinical outcomes of 55 patients with advanced pancreatic cancer undergoing palliative therapy or best supportive care (BSC). The skeletal muscle index (SMI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and visceral to subcutaneous adipose tissue area ratio (VSR) were calculated based on the cross-sectional area on two sets of computed tomography images obtained at cancer diagnosis and 1 month later before treatment. The prognostic value of body composition indexes at diagnosis and the changes in those indexes over 1 month was then evaluated. RESULTS: In total, 45 patients (81.8%) received chemotherapy, chemoradiation, or radiation therapy, whereas the remaining patients underwent BSC. There were 27 patients (49.1%) who had low SMI at cancer diagnosis. Univariate analysis showed no significant associations between the baseline body composition indexes including SMI, VATI, SATI, and VSR and survival. Meanwhile, male sex (HR, 2.79; 95% CI, 1.16-6.71, p = 0.022) and higher decrease in VATI over 1 month (HR, 2.41; 95% CI, 1.13-5.13, p = 0.023) were identified as independent risk factors for mortality in multivariate analysis. CONCLUSION: Rapid decline in VAT over 1 month is closely associated with poorer survival in unresectable advanced pancreatic cancer. A short-term assessment of body composition changes may be a rational approach to predict prognosis in these patients.

DOI： 10.1002/cam4.3964

PubMed

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被包化膵壊死への真菌感染による敗血症性ショックをきたした一例

山田麻理奈[大越], 上村顕也, 石川夏生, 小関洋平, 田中裕登, 水澤健, 佐藤裕樹, 五十嵐聡, 林和直, 坂牧僚, 横山純二, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 37 ( 1 ) 30 - 30 2021.7

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自己免疫性膵炎と膵癌との鑑別の現状と課題

小川光平, 林和直, 五十嵐聡, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 37 ( 1 ) 32 - 32 2021.7

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感染性被包化と壊死門脈瘻を伴う膵仮性嚢胞の一例(A case of pancreatic pseudocyst-portal vein fistula with infected walled off necrosis)

前田悠一郎, 林和直, 戸田遼, 若林拓哉, 木村究, 水戸將貴, 小島雄一, 小川光平, 荒生祥尚, 木村成宏, 五十嵐聡, 土屋淳紀, 徳永麻美, 佐藤知巳, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 68回 35 - 35 2021.6

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Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis. International journal

Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yosida, Yuzo Kawata, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Junji Yokoyama, Toshifumi Wakai, Shuji Terai

Biochemistry and biophysics reports 25 100892 - 100892 2021.3

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It is reported that an increase in aerobic bacteria, a lack of short-chain fatty acids (SCFAs), and immune disorders in the diverted colon are major causes of diversion colitis. However, the precise pathogenesis of this condition remains unclear. The aim of the present study was to examine the microbiota, intestinal SCFAs, and immunoglobulin A (IgA) in the diverted colon. Eight patients underwent operative procedures for colostomies. We assessed the diverted colon using endoscopy and obtained intestinal samples from the diverted colon and oral colon in these patients. We analyzed the microbiota and SCFAs of the intestinal samples. The bacterial communities were investigated using a 16S rRNA gene sequencing method. The microbiota demonstrated a change in the proportion of some species, especially Lactobacillus, which significantly decreased in the diverted colon at the genus level. We also showed that intestinal SCFA values were significantly decreased in the diverted colon. Furthermore, intestinal IgA levels were significantly increased in the diverted colon. This study was the first to show that intestinal SCFAs were significantly decreased and intestinal IgA was significantly increased in the diverted colon. Our data suggest that SCFAs affect the microbiota and may play an immunological role in diversion colitis.

DOI： 10.1016/j.bbrep.2020.100892

PubMed

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消化器領域の救急医療、集中治療:急性膵炎予後因子・CT gradeを用いた重症急性膵炎の予後・感染性被包化膵壊死合併の予測

林和直, 五十嵐聡, 寺井崇二

日本消化器病学会雑誌 118 ( 臨増総会 ) A251 - A251 2021.3

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高齢者膵癌に対する治療の適応と限界県全域における高齢者膵癌診療の現状多施設後方視的研究の結果より

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 118 ( 臨増総会 ) A237 - A237 2021.3

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Comparison of Oral and Esophageal Microbiota in Patients with Achalasia Before and After Peroral Endoscopic Myotomy. International journal

Kazuya Takahashi, Hiroki Sato, Takeshi Mizusawa, Kentaro Tominaga, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 32 ( 1 ) 42 - 52 2021.1

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BACKGROUND/AIMS: Patients with achalasia have a high incidence of esophageal squamous cell carcinoma (ESCC), which may be associated with alterations in oral and esophageal microbiota caused by food stasis. This study compared the oral and esophageal microbiota of patients with achalasia before and after peroral endoscopic myotomy (POEM). It also compared patients with achalasia to those with ESCC. MATERIALS AND METHODS: The study prospectively examined 6 patients with achalasia and 14 with superficial ESCC. Oral samples obtained from the buccal mucosa using a swab and esophageal samples obtained from the mid-esophagus using a brush via endoscopy were analyzed by 16S rRNA metagenome sequencing. Additionally, endoscopic and histological findings of patients with achalasia before and after POEM were prospectively compared. RESULTS: In patients with achalasia, Streptococcus was most abundant in both the oral and the esophageal microbiota, and these microbiota were significantly different. Although the overall structure of the oral and esophageal microbiota did not change after POEM, the relative abundance rate of Haemophilus and Neisseria increased in the esophagus, and endoscopic findings of inflammation improved after POEM (P = .04). The relative abundance of microbiota was not different among patients with achalasia from those with ESCC. CONCLUSIONS: The oral and esophageal microbiota were significantly different in patients with achalasia, and some of the composition of the esophageal microbiota changed after POEM. However, these findings and disease-specific microbiota should be further evaluated in large-scale studies.

DOI： 10.5152/tjg.2020.19995

PubMed

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Liver cirrhosis with ruptured splenic artery aneurysm leading to hepatitis c treatment: A case report

Yuki Hojo, Hiroteru Kamimura, Takashi Owaki, Rika Kimura, Takahiro Iwasawa, Yusuke Watanabe, Masafumi Takatsuna, Satoshi Ikarashi, Masaaki Takamura, Toru Setsu, Yoshihisa Arao, Yosuke Horii, Tatsuhiko Sato, Shuji Terai

Acta Hepatologica Japonica 62 ( 11 ) 749 - 755 2021

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DOI： 10.2957/kanzo.62.749

Scopus

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Choledochocele observed on direct peroral cholangioscopy using an ultra-slim endoscope.

Satoshi Ikarashi, Kazunao Hayashi, Shuji Terai

Journal of hepato-biliary-pancreatic sciences 2020.12

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DOI： 10.1002/jhbp.884

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Usefulness of ultrasonography to assess the response to steroidal therapy for the rare case of type 2b immunoglobulin G4-related sclerosing cholangitis without pancreatitis: A case report. International journal

Yuto Tanaka, Kenya Kamimura, Ryota Nakamura, Marina Ohkoshi-Yamada, Yohei Koseki, Takeshi Mizusawa, Satoshi Ikarashi, Kazunao Hayashi, Hiroki Sato, Akira Sakamaki, Junji Yokoyama, Shuji Terai

World journal of clinical cases 8 ( 22 ) 5821 - 5830 2020.11

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BACKGROUND: A type 2b immunoglobulin G4 (IgG4)-related sclerosing cholangitis (SC) without autoimmune pancreatitis is a rare condition with IgG4-SC. While the variety of the imaging modalities have tested its usefulness in diagnosing the IgG4-SC, however, the usage of ultrasonography for the assessment of the response to steroidal therapy on the changes of bile duct wall thickness have not been reported in the condition. Therefore, the information of our recent case and reported cases have been summarized. CASE SUMMARY: We report the case of an 82-year-old Japanese man diagnosed with isolated IgG4-related SC based on the increase of serum IgG4, narrowing of the bile duct, its wall thickness, no complication of autoimmune pancreatitis, and IgG4 positive inflammatory cell infiltration to the wall with the fibrotic changes. The cholangiogram revealed type 2b according to the classification. Corticosteroid treatment showed a favorable effect, with the smooth decrease in serum IgG4 and the improvement of the bile duct wall thickness. CONCLUSION: As isolated type 2b, IgG4-SC is rare, the images, histological findings, and clinical course of our case will be helpful for physicians to diagnose and treat the new cases appropriately.

DOI： 10.12998/wjcc.v8.i22.5821

PubMed

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良悪性鑑別困難な胆膵疾患の診断と治療の最前線-内科、外科の立場から- 自己免疫性膵炎と膵癌との鑑別の現状と課題

小川光平, 林和直, 五十嵐聡, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 67回 32 - 32 2020.11

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急性腹症を契機にC型慢性肝炎が発見された1例

北條雄暉, 上村博輝, 木村莉菓, 大脇崇史, 岩澤貴宏, 渡邉雄介, 高綱将史, 荒生祥尚, 薛徹, 五十嵐聡, 高村昌昭, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 67回 96 - 96 2020.11

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被包化膵壊死への真菌感染による敗血症性ショックをきたした一例

山田麻理奈[大越], 上村顕也, 石川夏生, 小関洋平, 田中裕登, 水澤健, 佐藤裕樹, 五十嵐聡, 林和直, 坂牧僚, 横山純二, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 67回 26 - 26 2020.11

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短期間に急速な肝脂肪沈着と栄養・運動介入による肝機能の改善を確認できたアスリートの一例

上村博輝, 木村莉菓, 北條雄暉, 渡邊雄介, 高綱将史, 五十嵐聡, 佐野正和, 真田奈緒, 武田安永, 小師優子, 高村昌昭, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 67回 97 - 97 2020.11

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急性膵炎およびその合併症治療の最前線新潟県における重症急性膵炎の予後改善を目指して Niigata SAP network

林和直, 五十嵐聡, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増大会 ) A624 - A624 2020.10

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重症急性膵炎後Walled-off necrosisの内視鏡治療におけるLumen apposing metal stentの有効性

五十嵐聡, 林和直, 寺井崇二

Gastroenterological Endoscopy 62 ( Suppl.2 ) 2162 - 2162 2020.10

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急性膵炎およびその合併症治療の最前線新潟県における重症急性膵炎の予後改善を目指して Niigata SAP network

林和直, 五十嵐聡, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増大会 ) A624 - A624 2020.10

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Effectiveness of Endoscopic Pancreatic Stenting for Pancreatic Pseudocyst-Portal Vein Fistula

Atsushi Kimura, Kazunao Hayashi, Chiyumi Oda, Kazunori Hosaka, Naruhiro Kimura, Kentaro Tominaga, Satoshi Ikarashi, Atsunori Tsuchiya, Shuji Terai

CASE REPORTS IN GASTROENTEROLOGY 14 ( 3 ) 570 - 576 2020.9

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DOI： 10.1159/000510331

Web of Science

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側方発育型大腸腫瘍と肥満ならびに代謝指数に関する検討

高綱将史, 水野研一, 川田雄三, 冨永顕太郎, 水澤健, 佐藤裕樹, 五十嵐聡, 林和直, 横山純二, 橋本哲, 寺井崇二

Gastroenterological Endoscopy 62 ( Suppl.1 ) 1332 - 1332 2020.8

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肝胆膵疾患における血清DPPIV解析

林和直, 五十嵐聡, 土屋淳紀, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A387 - A387 2020.7

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オステオポンチン・脂肪酸・高トリグリセライド血症による膵癌高リスク患者の同定

五十嵐聡, 林和直, 寺井崇二

膵臓 35 ( 3 ) A305 - A305 2020.7

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膵癌早期発見を目指した新潟県膵癌ネットワーク(Phoenix Study)の構築と膵癌病態解析に関する多施設後方視的観察研究

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A258 - A258 2020.7

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当院におけるIgG4関連硬化性胆管炎の診断の現状と課題

田中裕登, 林和直, 五十嵐聡, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A298 - A298 2020.7

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Risk factors for walled-off necrosis associated with severe acute pancreatitis: A multicenter retrospective observational study. Reviewed

Satoshi Ikarashi, Hirokazu Kawai, Kazunao Hayashi, Junji Kohisa, Toshifumi Sato, Yujiro Nozawa, Shinichi Morita, Hiromitsu Oka, Munehiro Sato, Yukio Aruga, Seiichi Yoshikawa, Shuji Terai

Journal of hepato-biliary-pancreatic sciences 27 ( 11 ) 887 - 895 2020.6

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BACKGROUND: This study aimed to identify the risk factors for walled-off necrosis (WON) associated with severe acute pancreatitis (SAP). METHODS: This retrospective study was conducted in eight institutions in Japan between 2014 and 2017. We analyzed WON incidence, patient characteristics, and risk factors for WON in patients with SAP who were observed for >28 days. RESULTS: Of 134 patients with SAP, WON occurred in 40 (29.9%). Male sex (P = .045), body mass index (BMI) ≥25 (P < .001), post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (P = .020), and disseminated intravascular coagulation (DIC) (P = .001) were more frequent in the WON group than in the non-WON group. On admission, the frequency of white blood cell counts ≥ 12 000/µL (P = .037) and hypoenhanced pancreatic lesion on computed tomography (P = .047) were significantly higher in the WON group. In multivariate analysis, BMI ≥ 25 (odds ratio [OR] 5.73, 95% confidence interval [CI] 1.95-16.8; P = .002), post-ERCP (OR 8.08, 95% CI 1.57-41.7; P = .013), and DIC (OR 3.52, 95% CI 1.20-10.4; P = .022) were independent risk factors for WON. CONCLUSIONS: High BMI, post-ERCP pancreatitis, and DIC are risk factors for the development of WON associated with SAP.

DOI： 10.1002/jhbp.787

PubMed

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心窩部痛、肝障害を契機に発見されたcholedochoceleの一例

岩澤貴宏, 五十嵐聡, 林和直, 大脇崇史, 上村博輝, 橋本哲, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 35 ( 2 ) 152 - 152 2019.12

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IgG4関連硬化性胆管炎の一例

中村涼太, 田中裕登, 大越麻里奈, 小関洋平, 水澤健, 五十嵐聡, 林和直, 佐藤裕樹, 坂牧僚, 上村顕也, 横山純二, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 65回 81 - 81 2019.11

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さあ、どうする?治療内視鏡におけるトラブルシューティング(胆膵編) 当科における副乳頭アプローチカニュレーションの工夫

林和直, 五十嵐聡, 寺井崇二

Gastroenterological Endoscopy 61 ( Suppl.2 ) 2055 - 2055 2019.10

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急性膵炎後の諸問題に対する内視鏡の役割重症急性膵炎後Walled-off necrosisに対するLumen apposing metal stentの有効性

五十嵐聡, 林和直, 寺井崇二

Gastroenterological Endoscopy 61 ( Suppl.2 ) 2066 - 2066 2019.10

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Change in body composition in patients with achalasia before and after peroral endoscopic myotomy. Reviewed International journal

Takeshi Mizusawa, Hiroki Sato, Kenya Kamimura, Satoru Hashimoto, Ken-Ichi Mizuno, Hiroteru Kamimura, Satoshi Ikarashi, Kazunao Hayashi, Masaaki Takamura, Junji Yokoyama, Shuji Terai

Journal of gastroenterology and hepatology 35 ( 4 ) 601 - 608 2019.8

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BACKGROUND AND AIM: Patients with achalasia experience weight loss because of dysphagia caused by impaired relaxation of the lower esophageal sphincter. This study aimed to use dual bioelectrical impedance analysis (BIA) to determine the change in bodyweight and body composition in patients with achalasia before and after peroral endoscopic myotomy (POEM). METHODS: Patients with achalasia who underwent POEM from 2013 to 2018 (n = 72) were retrospectively analyzed for change in bodyweight before and after 3 months. Additionally, change in body composition was prospectively investigated in the final 10 of 72 patients using non-radiation dual BIA. RESULTS: Twenty patients (27.8%) were underweight (body mass index < 18.5) before undergoing POEM. No clinical parameters were identified to be associated with the underweight condition before POEM and be predictive of an increase in bodyweight after POEM. Low visceral fat volume observed on dual BIA correlated closely with the result obtained using computed tomography (Pearson correlation coefficient: r = 0.850, P < 0.01). Patients with achalasia had a statistically significant increase in visceral (P < 0.01) and subcutaneous fat volumes (P < 0.01) after POEM. Skeletal muscle mass index slightly increased (P = 0.02), although the value after POEM was still low. No blood biomarkers were indicators for low bodyweight or low visceral fat volume. CONCLUSIONS: Dual BIA is an effective non-invasive tool to evaluate the change in body composition of underweight patients with achalasia. Skeletal muscle volume was not enough after POEM, although a rapid increase in the intra-abdominal fat volume was observed. Additional studies are warranted to understand the pathological implications.

DOI： 10.1111/jgh.14847

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Delayed pancreatic ductal leakage after EUS-FNA for autoimmune pancreatitis. Reviewed

Ikarashi S, Tsuchiya A, Hayashi K, Terai S

Endoscopic ultrasound 8 ( 4 ) 277 - 278 2019.7

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DOI： 10.4103/eus.eus_55_18

Web of Science

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医学・医療におけるシミュレータの進歩と普及(Vol.23) 消化器領域超音波のシミュレータ腹部超音波/超音波内視鏡

林和直, 五十嵐聡, 寺井崇二

医学のあゆみ 269 ( 12 ) 945 - 948 2019.6

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膵癌術前胆道ドレナージにおける大口径プラスチックステントの役割

五十嵐聡, 林和直, 寺井崇二, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 高村昌昭

Gastroenterological Endoscopy 61 ( Suppl.1 ) 981 - 981 2019.5

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慢性膵炎による膵管狭窄に対するステント治療の現状と課題

林和直, 五十嵐聡, 寺井崇二, 水澤健, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二

Gastroenterological Endoscopy 61 ( Suppl.1 ) 1000 - 1000 2019.5

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当院における切除不能局所進行膵癌の治療の現況

林和直, 五十嵐聡, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A468 - A468 2019.3

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術後再建腸管例におけるEUS-FNAの現状と工夫

五十嵐聡, 林和直, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 高村昌昭, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A299 - A299 2019.3

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Early injection of human adipose tissue-derived mesenchymal stem cell after inflammation ameliorates dextran sulfate sodium-induced colitis in mice through the induction of M2 macrophages and regulatory T cells. Reviewed

Kawata Y, Tsuchiya A, Seino S, Watanabe Y, Kojima Y, Ikarashi S, Tominaga K, Yokoyama J, Yamagiwa S, Terai S

Cell and tissue research 376 ( 2 ) 257 - 271 2019.1

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DOI： 10.1007/s00441-018-02981-w

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肝胆膵疾患に対する低侵襲治療の工夫当院におけるWalled-off necrosis(WON)に対する内視鏡治療成績の検討

林和直, 五十嵐聡, 河久順志, 横山純二, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 34 ( 2 ) 189 - 189 2018.12

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Gastrointestinal: A case of hypereosinophilic syndrome with esophageal involvement. Reviewed

Takahashi K, Sato H, Tominaga K, Kohisa J, Ikarashi S, Hayashi K, Miuzno K, Hashimoto S, Yokoyama J, Terai S

Journal of gastroenterology and hepatology 33 ( 11 ) 1817 2018.11

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DOI： 10.1111/jgh.14312

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高齢者消化器疾患に対する治療方針高齢者の術後再建腸管に対するERCPの検討

水澤健, 五十嵐聡, 林和直, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 63回 47 - 47 2018.11

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フレイルとサルコペニアについて進行消化器癌における体組成と予後との関連

川合弘一, 小林隆昌, 中野応央樹, 五十嵐聡, 河久順志, 阿部聡司, 上村博輝, 坂牧僚, 林和直, 上村顕也, 土屋淳紀, 高村昌昭, 寺井崇二

新潟医学会雑誌 132 ( 10 ) 350 - 352 2018.10

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超音波内視鏡における音速補正モードの有用性

林和直, 五十嵐聡, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy 60 ( Suppl.2 ) 2110 - 2110 2018.10

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ステロイド使用例における胆管結石治療の現状

五十嵐聡, 林和直, 河久順志, 冨永顕太郎, 高橋一也, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy 60 ( Suppl.2 ) 2086 - 2086 2018.10

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Management decision based on lymphovascular involvement leads to favorable outcomes after endoscopic treatment of esophageal squamous cell carcinoma Reviewed

Kazuya Takahashi, Satoru Hashimoto, Ken-Ichi Mizuno, Takamasa Kobayashi, Kentaro Tominaga, Hiroki Sato, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Manabu Takeuchi, Junji Yokoyama, Hirokazu Kawai, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

Endoscopy 50 ( 7 ) 662 - 670 2018.7

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Language：English Publishing type：Research paper (scientific journal) Publisher：Georg Thieme Verlag

DOI： 10.1055/s-0043-124433

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IS ENDOSCOPIC SUBMUCOSAL DISSECTION A FEASIBLE TREATMENT FOR ESOPHAGOGASTRIC JUNCTION CANCER? Reviewed

Takahashi Kazuya, Hashimoto Satoru, Mizuno Kenichi, Sato Hiroki, Tominaga Kentaro, Kohisa Junji, Ikarashi Satoshi, Hayashi Kazunao, Yokoyama Junji, Terai Shuji

GASTROINTESTINAL ENDOSCOPY 87 ( 6 ) AB396 - AB397 2018.6

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ENDOSCOPIC MANAGEMENT OF UNRESECTABLE MALIGNANT HILAR STRICTURES USING THREADED INSIDE STENTS VERSUS METALLIC STENTS Reviewed

Hayashi Kazunao, Ikarashi Satoshi, Kohisa Junji, Takahashi Kazuya, Tominaga Kentaro, Mizuno Ken-ichi, Hashimoto Satoru, Yokoyama Junji, Yamagiwa Satoshi, Terai Shuji

GASTROINTESTINAL ENDOSCOPY 87 ( 6 ) AB208 - AB208 2018.6

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SAFETY AND EFFICACY OF PROPOFOL-BASED SEDATION FOR BALLOON ENTEROSCOPE-ASSISTED ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN ELDERLY PATIENTS Reviewed

Kohisa Junji, Ikarashi Satoshi, Hayashi Kazunao, Takahashi Kazuya, Tominaga Kentaro, Mizuno Kenichi, Hashimoto Satoru, Yokoyama Junji, Yamagiwa Satoshi, Terai Shuji

GASTROINTESTINAL ENDOSCOPY 87 ( 6 ) AB229 - AB229 2018.6

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IS ENDOSCOPIC SUBMUCOSAL DISSECTION VALUABLE FOR ELDERLY PATIENTS WITH SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA? Reviewed

Hashimoto Satoru, Mizuno Kenichi, Takahashi Kazuya, Sato Hiroki, Tominaga Kentaro, Kohisa Junji, Ikarashi Satoshi, Hayashi Kazunao, Yokoyama Junji, Terai Shuji

GASTROINTESTINAL ENDOSCOPY 87 ( 6 ) AB287 - AB287 2018.6

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RISK FACTORS FOR WALLED-OFF NECROSIS ASSOCIATED WITH SEVERE ACUTE PANCREATITIS: A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY

Satoshi Ikarashi, Kazunao Hayashi, Hirokazu Kawai, Junji Kohisa, Toshifumi Sato, Yujiro Nozawa, Shinichi Morita, Hiromitsu Oka, Munehiro Sato, Yukio Aruga, Seiichi Yoshikawa, Shuji Terai

GASTROENTEROLOGY 154 ( 6 ) S289 - S289 2018.5

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当院における非切除悪性肝門部胆管狭窄に対する内視鏡的ステント留置術の現状と課題

林和直, 五十嵐聡, 河久順志, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy 60 ( Suppl.1 ) 797 - 797 2018.4

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急性膵炎診療Up-to-date 重症急性膵炎におけるwalled-off necrosis合併のリスク因子に関する多施設共同後方視的研究

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 115 ( 臨増総会 ) A176 - A176 2018.3

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切除不能膵癌における好中球リンパ球比と他の炎症・栄養指標による予後予測能の比較検討

中野応央樹, 川合弘一, 小林隆昌, 河久順志, 五十嵐聡, 林和直, 横山順二, 寺井崇二

日本消化器病学会雑誌 115 ( 臨増総会 ) A373 - A373 2018.3

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Full-layer mucosal histology in achalasia: Histological epithelial wave is characteristic in “pinstripe pattern”-positive achalasia Reviewed

H. Sato, K. Takahashi, N. Nakajima, G. Hasegawa, K. Mizuno, S. Hashimoto, S. Ikarashi, K. Hayashi, Y. Honda, J. Yokoyama, Y. Sato, S. Terai

Neurogastroenterology and Motility 30 ( 1 ) 2018.1

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Language：English Publishing type：Research paper (scientific journal) Publisher：Blackwell Publishing Ltd

DOI： 10.1111/nmo.13168

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Jackhammer esophagus accompanied by esophageal intramural pseudodiverticulosis Reviewed

Kazuya Takahashi, Satoshi Ikarashi, Junji Yokoyama, Shuji Terai

Internal Medicine 57 ( 7 ) 1051 - 1052 2018

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Language：English Publisher：Japanese Society of Internal Medicine

DOI： 10.2169/internalmedicine.9734-17

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A Case of Pancreatic Schwannoma Diagnosed Preoperatively by Endoscopic Ultrasonography-Guided Fine Needle Aspiration and Treated with Laparoscopic Surgery. Reviewed International journal

Hayashi K, Tsuchiya A, Ikarashi S, Takizawa K, Terai S

Journal of pancreatic cancer 4 ( 1 ) 7 - 10 2018

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Background: Pancreatic tumors are often difficult to diagnose in atypical cases, and a pancreatic schwannoma is very rare. We present a case of pancreatic schwannoma with calcification diagnosed preoperatively by endoscopic ultrasonography (EUS)-guided fine needle aspiration (FNA) and treated with laparoscopic distal pancreatectomy. Presentation: A 72-year-old-woman was admitted to our hospital due to a 6 × 4.5 cm large tumor in the pancreatic tail. Imaging modalities revealed that the tumor was hypovascular and gradually enhanced with calcification, but was without cystic lesions. EUS revealed the tumor had a clear boundary with a low echoic mass. EUS-FNA was performed and spindle-shaped cells that were immunopositive for S-100 and negative for c-kit, CD34, and desmin were detected, resulting in a diagnosis of schwannoma. Laparoscopic distal pancreatectomy with splenectomy was safely performed without recurrence for a year. Conclusions: Schwannoma is very rare; however, characteristics of the tumor, such as calcification, can help the diagnosis and, if possible, EUS-FNA should be performed for an appropriate treatment decision.

DOI： 10.1089/pancan.2018.0002

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Factors associated with delayed hemorrhage after endoscopic sphincterotomy: Japanese large single-center experience Reviewed

Satoshi Ikarashi, Akio Katanuma, Toshifumi Kin, Kuniyuki Takahashi, Kei Yane, Itsuki Sano, Hajime Yamazaki, Hiroyuki Maguchi

JOURNAL OF GASTROENTEROLOGY 52 ( 12 ) 1258 - 1265 2017.12

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DOI： 10.1007/s00535-017-1347-9

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Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor. Reviewed International journal

Hayashi K, Kamimura K, Hosaka K, Ikarashi S, Kohisa J, Takahashi K, Tominaga K, Mizuno K, Hashimoto S, Yokoyama J, Yamagiwa S, Takizawa K, Wakai T, Umezu H, Terai S

World journal of gastrointestinal endoscopy 9 ( 12 ) 583 - 589 2017.12

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Duodenal gastrointestinal stromal tumors (GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure.

DOI： 10.4253/wjge.v9.i12.583

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Efficacy and Safety of Pancreas-Targeted Hydrodynamic Gene Delivery in Rats Reviewed

Kohei Ogawa, Kenya Kamimura, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Norihiro Sakai, Takuro Nagoya, Akira Sakamaki, Satoshi Abe, Kazunao Hayashi, Satoshi Ikarashi, Junji Kohisa, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

MOLECULAR THERAPY-NUCLEIC ACIDS 9 80 - 88 2017.12

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DOI： 10.1016/j.omtn.2017.08.009

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Changes in esophageal motility after endoscopic submucosal dissection for superficial esophageal cancer: A high-resolution manometry study Reviewed

Kazuya Takahashi, Y. Sato, M. Takeuchi, H. Sato, N. Nakajima, S. Ikarashi, K. Hayashi, K. I. Mizuno, Y. Honda, S. Hashimoto, J. Yokoyama, S. Terai

Diseases of the Esophagus 30 ( 11 ) 1 - 8 2017.11

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Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press

DOI： 10.1093/dote/dox057

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Changes in esophageal motility after endoscopic submucosal dissection for superficial esophageal cancer: a high-resolution manometry study Reviewed

K. Takahashi, Y. Sato, M. Takeuchi, H. Sato, N. Nakajima, S. Ikarashi, K. Hayashi, K. -I. Mizuno, Y. Honda, S. Hashimoto, J. Yokoyama, S. Terai

DISEASES OF THE ESOPHAGUS 30 ( 11 ) 2017.11

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DOI： 10.1093/dote/dox057

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Innovative therapeutic endoscopy 膵仮性嚢胞・感染性WONに対する内視鏡的治療重症急性膵炎後Walled-off necrosisの自然軽快に関連する因子

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増大会 ) A689 - A689 2017.9

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当院におけるBordeline resectable膵癌の治療の現況

林和直, 五十嵐聡, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増大会 ) A832 - A832 2017.9

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Innovative therapeutic endoscopy 膵仮性嚢胞・感染性WONに対する内視鏡的治療重症急性膵炎後Walled-off necrosisの自然軽快に関連する因子

五十嵐聡, 林和直, 寺井崇二

Gastroenterological Endoscopy 59 ( Suppl.2 ) 2103 - 2103 2017.9

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Development and use of a non-biomaterial model for hands-on training of endoscopic procedures Reviewed

Hiroki Sato, Ken-Ichi Mizuno, Yuichi Sato, Satoru Hashimoto, Kazunao Hayashi, Satoshi Ikarashi, Yutaka Honda, Junji Yokoyama, Shuji Terai

Annals of Translational Medicine 5 ( 8 ) 182 2017.4

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Language：English Publishing type：Research paper (scientific journal) Publisher：AME Publishing Company

DOI： 10.21037/atm.2017.01.27

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Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis Reviewed

Hiroki Sato, Nao Nakajima, Kazuya Takahashi, Go Hasegawa, Ken-ichi Mizuno, Satoru Hashimoto, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

WORLD JOURNAL OF GASTROENTEROLOGY 23 ( 13 ) 2414 - 2423 2017.4

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DOI： 10.3748/wjg.v23.i13.2414

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術後再建腸管例に対するERCP関連手技における偶発症の現状と対策

五十嵐聡, 林和直, 水野研一, 本田穣, 橋本哲, 横山純二, 佐藤祐一, 山際訓, 寺井崇二

Gastroenterological Endoscopy 59 ( Suppl.1 ) 1035 - 1035 2017.4

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当科における術後再建腸管の胆管結石症に対する内視鏡治療の検討

林和直, 五十嵐聡, 水野研一, 本田穣, 橋本哲, 横山純二, 佐藤祐一, 山際訓, 寺井崇二

Gastroenterological Endoscopy 59 ( Suppl.1 ) 1036 - 1036 2017.4

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膵癌非切除例における骨格筋量と体脂肪組成の評価による予後解析

中野応央樹, 川合弘一, 小林隆昌, 五十嵐聡, 林和直, 佐藤祐一, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増総会 ) A271 - A271 2017.3

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当科におけるCrohn病に合併した胆石症の検討

林和直, 五十嵐聡, 水野研一, 本田穣, 橋本哲, 横山純二, 佐藤祐一, 山際訓, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増総会 ) A335 - A335 2017.3

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他臓器癌合併IPMNの臨床像

五十嵐聡, 林和直, 水野研一, 本田穣, 橋本哲, 横山純二, 佐藤祐一, 山際訓, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増総会 ) A372 - A372 2017.3

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Loss of peristalsis of the esophagus due to diffuse esophageal leiomyomatosis Reviewed

Kazuya Takahashi, Yui Ishii, Kazunao Hayashi, Satoshi Ikarashi, Hirokazu Kawai, Yuichi Sato, Shuji Terai

ENDOSCOPY 49 ( S 01 ) E95 - E96 2017.2

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DOI： 10.1055/s-0043-100691

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Early Detection of Hepatocellular Carcinoma Recurrence Using the Highly Sensitive Fucosylated Fraction of Alpha-Fetoprotein Reviewed

Toru Setsu, Atsunori Tsuchiya, Takayuki Watanabe, Takuro Nagoya, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

Case Reports in Gastroenterology 11 ( 1 ) 142 - 147 2017.1

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Language：English Publishing type：Research paper (scientific journal) Publisher：S. Karger AG

DOI： 10.1159/000462969

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Short-type single-balloon enteroscope-assisted ERCP in postsurgical altered anatomy: potential factors affecting procedural failure Reviewed

Kei Yane, Akio Katanuma, Hiroyuki Maguchi, Kuniyuki Takahashi, Toshifumi Kin, Satoshi Ikarashi, Itsuki Sano, Hajime Yamazaki, Koh Kitagawa, Kensuke Yokoyama, Hideaki Koga, Kazumasa Nagai, Masanori Nojima

ENDOSCOPY 49 ( 1 ) 69 - 74 2017.1

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DOI： 10.1055/s-0042-118301

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Pancreatic Metastasis from Rectal Cancer that was Diagnosed by Endoscopic Ultrasonography-guided Fine Needle Aspiration (EUS-FNA) Reviewed

Itsuki Sano, Akio Katanuma, Kei Yane, Toshifumi Kin, Kazumasa Nagai, Hajime Yamazaki, Hideaki Koga, Koh Kitagawa, Kensuke Yokoyama, Ikarashi T. Satoshi, Kuniyuki Takahashi, Hiroyuki Maguchi, Yuko Omori, Toshiya Shinohara

INTERNAL MEDICINE 56 ( 3 ) 301 - 305 2017

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DOI： 10.2169/internalmedicine.56.7213

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Two cases of cholangiocellular carcinoma complicated with Trousseau’s syndrome

Yoko Shinagawa, Kenya Kamimura, Norihiro Sakai, Daisuke Kumaki, Kohei Ogawa, Rie Azumi, Kentaro Tominaga, Akira Sakamaki, Satoshi Ikarashi, Kazunao Hayashi, Takashi Yamamoto, Kenichi Mizuno, Satoshi Yamagiwa, Shuji Terai

Acta Hepatologica Japonica 58 ( 9 ) 528 - 535 2017

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Hepatology

DOI： 10.2957/kanzo.58.528

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Endoscopic Removal of Ingested Dentures and Dental Instruments: A Retrospective Analysis Reviewed

Ken-ichi Mizuno, Kazuya Takahashi, Kentaro Tominaga, Yuki Nishigaki, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Takashi Yamamoto, Yutaka Honda, Satoru Hashimoto, Kenya Kamimura, Manabu Takeuchi, Junji Yokoyama, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

GASTROENTEROLOGY RESEARCH AND PRACTICE 2016 3537147 2016

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DOI： 10.1155/2016/3537147

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Current advancement of balloon-enteroscopy-assisted ERCP

KATANUMA Akio, MAGUCHI Hiroyuki, YANE Kei, KIN Toshifumi, IKARASHI Satoshi, YAMAZAKI Hajime, KITAGAWA Koh, KOGA Hideaki, YOKOYAMA Kensuke, SANO Itsuki, NAGAI Kazumasa, TAKAHASHI Kuniyuki

Nippon Shokakibyo Gakkai Zasshi 113 ( 4 ) 603 - 613 2016

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DOI： 10.11405/nisshoshi.113.603

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Successful reintervention of biliary stent occlusion after biliary and duodenal stenting by using argon plasma coagulation Reviewed

Toshifumi Kin, Akio Katanuma, Kuniyuki Takahashi, Manabu Osanai, Kei Yane, Satoshi Ikarashi, Manabu Sen-yo, Ryuki Minami, Itsuki Sano, Hajime Yamazaki, Hiroyuki Maguchi

GASTROINTESTINAL ENDOSCOPY 82 ( 2 ) 407 - 407 2015.8

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DOI： 10.1016/j.gie.2015.02.037

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Resected tumor seeding in stomach wall due to endoscopic ultrasonography-guided fine needle aspiration of pancreatic adenocarcinoma Reviewed

Akiko Tomonari, Akio Katanuma, Tomoaki Matsumori, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Toshiya Shinohara, Hiroyuki Maguchi

WORLD JOURNAL OF GASTROENTEROLOGY 21 ( 27 ) 8458 - 8461 2015.7

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DOI： 10.3748/wjg.v21.i27.8458

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Bench-top testing of suction forces generated through endoscopic ultrasound-guided aspiration needles Reviewed

Akio Katanuma, Takao Itoi, Todd H. Baron, Ichiro Yasuda, Toshifumi Kin, Kei Yane, Hiroyuki Maguchi, Hajime Yamazaki, Itsuki Sano, Ryuki Minami, Manabu Sen-yo, Satoshi Ikarashi, Manabu Osanai, Kuniyuki Takahashi

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES 22 ( 5 ) 379 - 385 2015.5

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DOI： 10.1002/jhbp.201

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Successful re-intervention with metal stent trimming using argon plasma coagulation after endoscopic ultrasound-guided hepaticogastrostomy Reviewed

Kei Yane, Akio Katanuma, Hiroyuki Maguchi, Kuniyuki Takahashi, Manabu Osanai, Toshifumi Kin, Satoshi Ikarashi, Ryuki Minami, Manabu Sen-yo, Itsuki Sano, Hajime Yamazaki

ENDOSCOPY 46 E391 - E392 2014

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DOI： 10.1055/s-0034-1377388

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Long-term outcomes of endoscopic papillary balloon dilation and endoscopic sphincterotomy for bile duct stones Reviewed

Masaaki Natsui, Yu Saito, Satoshi Abe, Akito Iwanaga, Satoshi Ikarashi, Yujiro Nozawa, Hiroto Nakadaira

DIGESTIVE ENDOSCOPY 25 ( 3 ) 313 - 321 2013.5

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DOI： 10.1111/j.1443-1661.2012.01393.x

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Re-evaluation of phenotypic expression in undifferentiated-type early gastric adenocarcinomas using mucin core protein and CDX2 Reviewed

Satoshi Ikarashi, Ken Nishikura, Yoichi Ajioka, Yutaka Aoyagi

GASTRIC CANCER 16 ( 2 ) 208 - 219 2013.4

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DOI： 10.1007/s10120-012-0172-3

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Two Cases of Pneumatosis Cystoides Intestinalis with Ulcerative Colitis

NAKANO Masato, SUDA Takeyasu, TERASHIMA Tetsuro, IKARASHI Satoshi, AJIOKA Yoichi

The Japanese journal of proctology 64 ( 6 ) 433 - 438 2011.6

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Pneumatosis cystoides intestinalis (PCI) is rarely associated with ulcerative colitis (UC) . We describe two cases of PCI who underwent restorative proctocolectomy for UC.<br> Case 1: A 31-year-old female diagnosed with UC at 23 years of age and treated with steroids was admitted to our hospital for abdominal distention. Examination revealed PCI extending from the ascending to transverse colon. Symptoms were relieved by hyperbaric oxygen therapy. Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) was performed because UC was intractable despite prolonged steroid treatment. Microscopic findings of the resected specimen were empty cysts in the submucosal layer extending from the caecum to the descending colon.<br> Case 2: A 34-year-old male diagnosed with UC (left-side colitis) at 23 years of age and treated with steroids was admitted to our hospital for restorative proctocolectomy with IPAA because UC was intractable. Examination revealed PCI extending from the ascending colon to hepatic flexure. Microscopic findings of the resected specimen were empty cysts in the submucosal layer of the ascending colon. Further evaluation of case studies is needed to clarify the pathogenesis of PCI associated with UC.<br>

DOI： 10.3862/jcoloproctology.64.433

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A CASE OF ADENOMA OF THE AMPULLA OF VATER PRESENTING AS PANCREATITIS TREATED BY ENDOSCOPIC PAPILLECTOMY

ISHIWATARI Hirotoshi, MAGUCHI Hiroyuki, TAKAHASHI Kuniyuki, KATANUMA Akio, OSANAI Manabu, ITOKAWA Fumihide, SANO Itsuki, MINAMI Ryuki, SEN-YO Manabu, IKARASHI Satoshi, MAGUCHI Hiroyuki

Suizo 48 ( 2 ) 183 - 190 2006.2

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Postoperative pancreaticoenteric anastomosis obstruction is a complication caused by pancreaticoduodenectomy-associated reconstruction. In the past, endoscopic treatment has been difficult because of anatomical reasons. The alternative treatment option was reoperation; however, it was largely invasive to the patient and has a risk of reocclusion. To address such problems, a balloon-assisted enteroscope has been used for postanastomotic stricture; however, it remains difficult to recognize the occlusion site of the pancreatic duct. To overcome such difficulty, the interventional EUS technique is used for such a condition. The usefulness of this technique has been reported. The 3 main interventional EUS techniques currently used are pancreaticoenterostomy, transenteric antegrade stenting, and rendezvous technique. The interventional EUS technique has been reported to have a procedure success rate of 76.1%, a clinical success rate of 91.7%, and a complication rate of 20.3%. Although this technique is a promising procedure, it has a high level of difficulty. Further studies will apparently be needed to clarify many aspects of the technique in terms of not only clinical efficacy but also long-term results.

DOI： 10.2958/suizo.30.183

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Eosinophilic gastrointestinal diseases.

川田雄三, 佐藤裕樹, 高橋一也, 田中裕登, 柴田理, 小島雄一, 中島尚, 冨永顕太郎, 五十嵐聡, 林和直, 水野研一, 寺井崇二

月刊呼吸器内科 47 ( 2 ) 2025

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オステオポンチン・脂肪酸・高トリグリセライド血症による膵癌高リスク患者の同定

五十嵐聡, 林和直, 寺井崇二

膵臓(Web) 35 ( 3 ) 2020

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側方発育型大腸腫瘍と肥満ならびに代謝指数に関する検討

高綱将史, 水野研一, 川田雄三, 冨永顕太郎, 水澤健, 佐藤裕樹, 五十嵐聡, 林和直, 横山純二, 橋本哲, 寺井崇二

Gastroenterological Endoscopy (Web) 62 ( Supplement1 ) 2020

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Antiprogramed cell death-1 therapy with microspheres for metastatic liver tumors. Reviewed International journal

Hiroteru Kamimura, Nobutaka Takeda, Takashi Owaki, Takeshi Mizusawa, Takahiro Iwasawa, Satoshi Ikarashi, Satoru Hashimoto, Masaaki Takamura, Shuji Terai

JGH open : an open access journal of gastroenterology and hepatology 3 ( 6 ) 542 - 543 2019.12

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Anti-programmed cell death-1 therapy with microspheres is an effective treatment for metastatic liver tumors.

DOI： 10.1002/jgh3.12213

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CONSIDERATION OF SERUM IGA IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Kentaro Tominaga, Yuzo Kawata, Naruhiro Kimura, Takeshi Mizusawa, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Kenichi Mizuno, Satoru Hashimoto, Atsunori Tsuchiya, Junji Yokoyama, Shuji Terai

GASTROENTEROLOGY 156 ( 6 ) S847 - S847 2019.5

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慢性膵炎による膵管狭窄に対するステント治療の現状と課題

林和直, 五十嵐聡, 寺井崇二, 水澤健, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二

Gastroenterological Endoscopy (Web) 61 ( Supplement1 ) 2019

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膵癌術前胆道ドレナージにおける大口径プラスチックステントの役割

五十嵐聡, 林和直, 寺井崇二, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 高村昌昭

Gastroenterological Endoscopy (Web) 61 ( Supplement1 ) 2019

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当科における副乳頭アプローチカニュレーションの工夫

林和直, 五十嵐聡, 寺井崇二

Gastroenterological Endoscopy (Web) 61 ( Supplement2 ) 2019

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乳癌手術24年後に消化管,リンパ節,皮膚,骨に多発転移をきたした1例

大脇崇史, 橋本哲, 岩澤貴宏, 水澤健, 五十嵐聡, 上村博輝, 高村昌昭, 周啓亮, 松本吉史, 梅津哉, 寺井崇二

Endoscopic Forum for Digestive Disease 35 ( 2 ) 2019

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術後再建腸管例におけるEUS-FNAの現状と工夫

五十嵐聡, 林和直, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 高村昌昭, 寺井崇二

日本消化器病学会雑誌(Web) 116 2019

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当院における切除不能局所進行膵癌の治療の現況

林和直, 五十嵐聡, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 寺井崇二

日本消化器病学会雑誌(Web) 116 2019

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Pembrolizumabによる二次性硬化性胆管炎が疑われた一例

小川光平, 上村顕也, 阿部聡司, 高昌良, 冨永顕太郎, 河久順志, 五十嵐聡, 林和直, 坂牧僚, 水野研一, 横山純二, 寺井崇二

肝臓 59 ( Supplement 3 ) A990 - A990 2018.11

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HCV陽性腎移植レシピエントに対し直接作用型抗ウイルス薬(DAA)で抗ウイルス療法を行った二例

岩澤貴宏, 高村昌昭, 大脇崇史, 竹内卓, 五十嵐聡, 上村博輝, 橋本哲, 寺井崇二

肝臓 59 ( Supplement 3 ) A982 2018.11

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肝動脈化学塞栓療法が奏効した眼球原発悪性黒色腫の肝転移の3例

武田信峻, 水澤健, 上村博輝, 野尻俊介, 五十嵐聡, 橋本哲, 高村昌昭, 寺井崇二

肝臓 59 ( Supplement 3 ) A999 2018.11

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超音波内視鏡における音速補正モードの有用性

林和直, 五十嵐聡, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy 60 ( Suppl.2 ) 2110 - 2110 2018.10

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術後胆汁中膵酵素値とERCP後膵炎の関連

河久順志, 五十嵐聡, 林和直, 荒生祥尚, 阿部寛幸, 高橋一也, 渡邉順, 横山純二, 寺井崇二

Gastroenterological Endoscopy 60 ( Suppl.2 ) 2156 - 2156 2018.10

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ステロイド使用例における胆管結石治療の現状

五十嵐聡, 林和直, 河久順志, 冨永顕太郎, 高橋一也, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy 60 ( Suppl.2 ) 2086 - 2086 2018.10

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内臓脂肪面積と生活習慣病、胆膵疾患、膵脂肪変性に関する検討

河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 上村博輝, 高村昌昭, 横山純二, 川合弘一, 寺井崇二

日本消化器病学会雑誌 115 ( 臨増総会 ) A393 - A393 2018.4

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IPMNの悪性診断における膵液細胞診の役割

五十嵐聡, 林和直, 河久順志, 冨永顕太郎, 高橋一也, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy 60 ( Suppl.1 ) 671 - 671 2018.4

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プロポフォールを用いた鎮静によるバルーン内視鏡下ERCPの現況

河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 寺井崇二

Gastroenterological Endoscopy 60 ( Suppl.1 ) 762 - 762 2018.4

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当院における1型自己免疫性膵炎診療の現状と課題

林和直, 五十嵐聡, 木村成宏, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

日本消化器病学会雑誌 115 ( 臨増総会 ) A299 - A299 2018.4

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内臓脂肪面積と生活習慣病、胆膵疾患、膵脂肪変性に関する検討

河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 上村博輝, 高村昌昭, 横山純二, 川合弘一, 寺井崇二

日本消化器病学会雑誌 115 ( 臨増総会 ) A393 - A393 2018.4

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食道アカラシアの診断と治療戦略経口内視鏡的筋層切開術(POEM)後に生じる逆流性食道炎の検討

高橋一也, 佐藤裕樹, 冨永顕太郎, 河久順志, 五十嵐聡, 林和直, 水野研一, 橋本哲, 横山純二, 寺井崇二

日本消化管学会雑誌 2 ( Suppl. ) 135 - 135 2018.2

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プロポフォールを用いた鎮静によるバルーン内視鏡下ERCPの現況

河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 寺井崇二

Gastroenterological Endoscopy (Web) 60 ( Supplement1 ) 762(J‐STAGE) 2018

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IPMNの悪性診断における膵液細胞診の役割

五十嵐聡, 林和直, 河久順志, 冨永顕太郎, 高橋一也, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy (Web) 60 ( Supplement1 ) 671(J‐STAGE) 2018

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重症急性膵炎におけるwalled-off necrosis合併のリスク因子に関する多施設共同後方視的研究

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌(Web) 115 2018

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切除不能膵癌における好中球リンパ球比と他の炎症・栄養指標による予後予測能の比較検討

中野応央樹, 川合弘一, 小林隆昌, 河久順志, 五十嵐聡, 林和直, 横山順二, 寺井崇二

日本消化器病学会雑誌(Web) 115 2018

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内臓脂肪面積と生活習慣病,胆膵疾患,膵脂肪変性に関する検討

河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 上村博輝, 高村昌昭, 横山純二, 川合弘一, 寺井崇二

日本消化器病学会雑誌(Web) 115 2018

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経口内視鏡的筋層切開術(POEM)後に生じる逆流性食道炎の検討

高橋一也, 佐藤裕樹, 冨永顕太郎, 河久順志, 五十嵐聡, 林和直, 水野研一, 橋本哲, 横山純二, 寺井崇二

日本消化管学会雑誌 2 ( Supplement ) 2018

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ステロイド使用例における胆管結石治療の現状

五十嵐聡, 林和直, 河久順志, 冨永顕太郎, 高橋一也, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy (Web) 60 ( Supplement2 ) 2018

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超音波内視鏡における音速補正モードの有用性

林和直, 五十嵐聡, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

Gastroenterological Endoscopy (Web) 60 ( Supplement2 ) 2018

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当院における1型自己免疫性膵炎診療の現状と課題

林和直, 五十嵐聡, 木村成宏, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

日本消化器病学会雑誌(Web) 115 2018

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直接胆道鏡下での三脚鉗子を用いた結石除去術が有効であった胆管空腸吻合術後の肝内結石の1例

渡邉貴之, 五十嵐聡, 林和直, 名古屋拓郎, 薜徹, 土屋淳紀, 横山純二, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 33 ( 2 ) 131 - 131 2017.11

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Trousseau症候群を合併した胆管細胞癌の2例

品川陽子, 上村顕也, 酒井規裕, 熊木大輔, 小川光平, 安住里英, 冨永顕太郎, 坂牧僚, 五十嵐聡, 林和直, 山本幹, 水野研一, 山際訓, 寺井崇二

肝臓 58 ( 9 ) 528 - 535 2017.9

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当科における超高齢者の術後再建腸管に対するERCPの検討

河久順志, 五十嵐聡, 林和直, 高村昌昭, 横山純二, 寺井崇二

日本高齢消化器病学会誌 20 ( 1 ) 63 - 63 2017.7

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Long-Term Outcome of Endoscopic Submucosal Dissection in Esophageal Squamous Cell Carcinoma Invading Into the Muscularis Mucosa or Submucosa Up to 200 mu m

Kazuya Takahashi, Satoru Hashimoto, Kenichi Mizuno, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

GASTROINTESTINAL ENDOSCOPY 85 ( 5 ) AB108 - AB108 2017.5

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DOI： 10.1016/j.gie.2017.03.161

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Crohn病診療におけるMR enterographyの役割

本田穣, 横山純二, 冨永顕太郎, 高橋一也, 西垣佑紀, 五十嵐聡, 林和直, 水野研一, 橋本哲, 佐藤祐一, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増総会 ) A275 - A275 2017.3

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粘膜,粘膜下層,さらに筋層の時代へ~Minimally Invasive Treatmentの新たな潮流~〔粘膜下層に対するアプローチ〕Submucosal endoscopyによる筋層生検—経口内視鏡的食道筋層生検術(POEM‐b)による新しい知見—

佐藤裕樹, 佐藤裕樹, 高橋一也, 中島尚, 水野研一, 橋本哲, 五十嵐聡, 林和直, 本田穣, 横山純二, 佐藤祐一, 本間照, 寺井崇二

消化器内視鏡 29 ( 2 ) 273‐277 - 277 2017.2

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術後再建腸管例に対するERCP関連手技における偶発症の現状と対策

五十嵐聡, 林和直, 水野研一, 本田穣, 橋本哲, 横山純二, 佐藤祐一, 山際訓, 寺井崇二

Gastroenterological Endoscopy (Web) 59 ( Supplement1 ) 1035(J‐STAGE) 2017

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A novel training model made of polyvinyl alcohol hydrogel for endoscopic submucosal dissection

Ken-Chi Mizuno, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Satoru Hashimoto, Junji Yokoyama, Yuichi Sato, Shuji Terai

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 31 277 - 278 2016.11

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外傷を契機に形態変化を来した膵嚢胞性病変の1例

北川洸, 真口宏介, 高橋邦幸, 潟沼朗生, 矢根圭, 金俊文, 佐野逸紀, 五十嵐聡, 安保義恭, 大森優子, 篠原敏也

日本消化器画像診断研究会プログラム・抄録集 64th 2016

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新たに定義された“肝門部領域胆管癌”の診断と治療術前胆道ドレナージ-内視鏡的胆道ドレナージ-

真口宏介, 潟沼朗生, 矢根圭, 金俊文, 高橋邦幸, 五十嵐聡, 佐野逸紀, 山崎大, 古賀英彬, 北川洸, 横山健介, 永井一正

胆と膵 37 ( 1 ) 2016

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Feasibility of short-type single-balloon enteroscopy for the initial management of suspected biliary stenosis in patients with surgically altered anatomy

Kei Yane, Akio Katanuma, Hiroyuki Maguchi, Kuniyuki Takahashi, Manabu Osanai, Toshifumi Kin, Satoshi Ikarashi, Itsuki Sano, Kensuke Yokoyama, Koh Kitagawa, Hajime Yamazaki, Hideaki Koga, Kazumasa Nagai

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 30 229 - 229 2015.12

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【生検を極める】膵管生検と膵液細胞診の現状と手技の実際

五十嵐聡, 潟沼朗生, 真口宏介, 高橋邦幸, 小山内学, 矢根圭, 金俊文, 佐野逸紀, 横山健介, 北川洸, 山崎大, 古賀英彬, 永井一正

消化器内視鏡 27 ( 6 ) 1017 - 1025 2015.6

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Clinical Observation Is Possible for Branch Duct Type Intraductal Papillary Mucinous Neoplasms With Mural Nodules <= 6mm

Toshifumi Kin, Hiroyuki Maguchi, Kuniyuki Takahashi, Akio Katanuma, Manabu Osanai, Kei Yane, Satoshi Ikarashi, Manabu Sen-yo, Ryuki Minami, Itsuki Sano, Hajime Yamazaki

GASTROENTEROLOGY 148 ( 4 ) S522 - S522 2015.4

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【ここまでできる!消化器内視鏡治療】慢性膵炎に対する内視鏡治療

五十嵐聡, 真口宏介, 潟沼朗生, 高橋邦幸, 金俊文, 矢根圭

成人病と生活習慣病 45 ( 3 ) 399 - 407 2015.3

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Other Link： http://search.jamas.or.jp/link/ui/2015208566
ERCPマスターへのロードマップ応用編スコープ挿入困難例に対する対処法

潟沼朗生, 真口宏介, 佐野逸紀, 永井一正, 山崎大, 横山健介, 古賀英彬, 北川洸, 五十嵐聡, 金俊文, 矢根圭, 小山内学, 高橋邦幸

胆と膵 36 2015

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Difficult stoneへの挑戦-内視鏡的胆管結石治療 Difficult stoneに対する内視鏡治療

永井一正, 潟沼朗生, 古賀英彬, 北川洸, 横山健介, 五十嵐聡, 佐野逸紀, 山崎大, 金俊文, 矢根圭, 高橋邦幸, 真口宏介

消化器内視鏡 27 ( 12 ) 2015

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病理像から読みとる膵・胆道画像診断のコツ病理像をイメージした膵・胆道画像診断の実際-病理像と画像診断との対比-胆管狭窄の鑑別診断

金俊文, 真口宏介, 高橋邦幸, 潟沼朗生, 矢根圭, 五十嵐聡, 佐野逸紀, 山崎大, 横山健介, 北川洸, 古賀英彬, 永井一正

胆と膵 36 ( 12 ) 2015

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Utility of endoscopic ultrasound-guided fine needle aspiration for the diagnosis of pancreatobiliary cancer recurrence after surgical resection

Kei Yane, Akio Katanuma, Hiroyuki Maguchi, Kuniyuki Takahashi, Manabu Osanai, Toshifumi Kin, Satoshi Ikarashi, Ryuki Minami, Manabu Sen-Yo, Itsuki Sano, Hajime Yamazaki

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29 10 - 11 2014.11

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Diagnostic accuracy of EUS-FNA for WHO-grading of pancreatic neuroendocrine tumors

Itsuki Sano, Akio Katanuma, Hiroyuki Maguchi, Kuniyuki Takahashi, Manabu Osanai, Kei Yane, Kin Toshifumi, Satoshi Ikarashi, Manabu Sen-Yo, Ryuki Minami, Hajime Yamazaki

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29 38 - 38 2014.11

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Clinical features and long-term follow-up outcomes of serous cystic neoplasms of the pancreas

Manabu Sen-Yo, Hiroyuki Maguchi, Kuniyuki Takahashi, Akio Katanuma, Manabu Osanai, Kei Yane, Toshifumi Kin, Satoshi Ikarashi, Ryuki Minami, Itsuki Sano, Hajime Yamazaki

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29 38 - 38 2014.11

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7 重症急性膵炎に対しエラスポールを含めた集学的治療により救命し得た1例（Ⅰ.一般演題, 第14回新潟胆膵研究会）

塩路和彦, 小林正明, 佐藤聡史, 中村隆人, 五十嵐聡, 渡邉ゆか理, 兼藤努, 山本幹, 鈴木健司, 青柳豊

新潟医学会雑誌 128 ( 3 ) 137 - 137 2014.3

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Other Link： http://search.jamas.or.jp/link/ui/2014333855
ラジオ波焼灼術における硬膜外麻酔の鎮痛効果の検討

五十嵐聡, 川合弘一, 窪田智之, 土屋淳紀, 矢野雅彦, 田村康, 高村昌昭, 五十嵐正人, 山際訓, 須田剛士, 松田康伸, 大越章吾, 岡本学, 野本実, 青柳豊

肝臓 50 ( Suppl.2 ) A576 - A576 2009.9

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7 TS-1+ドセタキセル併用療法が奏効した進行胃癌の1例(I.一般演題,第8回新潟食道・胃癌研究会)

五十嵐聡, 秋山修宏, 本山展隆, 佐々木俊哉, 伊藤裕美, 船越和博, 加藤俊幸

新潟医学会雑誌 122 ( 10 ) 604 - 604 2008.10

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S-1+Docetaxel併用療法が奏効した進行胃癌の1症例

五十嵐聡, 秋山修宏, 本山展隆, 佐々木俊哉, 伊藤裕美, 船越和博, 加藤俊幸, 新井太

癌と化学療法 35 ( 2 ) 287 - 290 2008.2

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Research Projects

新規胆管癌モデル動物の解析によるヒト胆管癌の診断マーカーと治療標的分子の同定

Grant number：25K11197

2025.4 - 2029.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

五十嵐聡, 寺井崇二, 上村顕也

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Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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遺伝子導入によるラット胆管癌モデルの確立と浸潤能評価による病態マーカー開発

Grant number：21K07889

2021.4 - 2024.3

System name：科学研究費助成事業

Research category：基盤研究(C)

Awarding organization：日本学術振興会

五十嵐聡, 寺井崇二, 上村顕也, 横尾健

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

ハイドロダイナミック遺伝子導入法（HGD）によるラット胆管特異的な遺伝子導入のための注入パラメータを確立する。

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A development of novel rat model of pancreatic ductal adenocarcinoma and therapeutic options

Grant number：18K15745

2018.4 - 2021.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Early-Career Scientists

Awarding organization：Japan Society for the Promotion of Science

IKARASHI Satoshi

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

The aim of this study was to establish an animal model of pancreatic cancer utilizing the pancreas-targeted hydrodynamic gene delivery of human oncogenes in rats. To date, we have successfully developed a novel rat pancreatic cancer model safely and efficiently by optimizing gene delivery parameters, gene concentrations, and gene combinations in order to create efficiently a pancreatic cancer model. Following this development, we are clarifying the molecular mechanism of this pancreatic cancer model to identify the therapeutic target.

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