Updated on 2026/09/10

写真a

 
Kimura Yosuke
 
Organization
University Medical and Dental Hospital Respiratory Medicine and Infectious Disease Assistant Professor
Title
Assistant Professor
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Degree

  • 博士（医学） ( 2014.3   新潟大学 )

Research Interests

  • 気管支喘息

  • 呼吸器内科

  • アレルギー

Research Areas

  • Life Science / Respiratory medicine

Research History (researchmap)

  • Niigata University   Specially Appointed Assistant Professor

    2018.8

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Research History

  • Niigata University   Respiratory Medicine and Infectious Disease, University Medical and Dental Hospital   Assistant Professor

    2026.6

  • Niigata University   University Medical and Dental Hospital Respiratory Medicine and Infectious Disease   Specially Appointed Assistant Professor

    2020.4 - 2026.5

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2018.8 - 2020.3

Education

  • Niigata University   医学部   医学科

    2000.4 - 2006.3

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Professional Memberships

  • THE JAPAN SOCIETY FOR RESPIRATORY ENDOSCOPY

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • THE JAPANESE RESPIRATORY SOCIETY

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  • JAPANESE SOCIETY OF ALLERGOLOGY

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  • 日本呼吸ケアリハビリテーション学会

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  • THE JAPANESE SOCIETY FOR TUBERCULOSIS

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  • THE JAPANESE SOCIETY OF SLEEP RESEARCH

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  • THE JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES

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Qualification acquired

  • Doctor

 

Papers

  • Successful Treatment with Mycophenolate Mofetil in a Patieint with Anti-MDA 5 Antibody-positive Interstitial Lung Disease and Posterior Reversible Encephalopathy syndrome: A Case Report.

    Kentaro Tanaka, Yosuke Kimura, Ami Aoki, Mio Toyama-Kousaka, Kenjiro Shima, Toshiyuki Koya, Toshiaki Kikuchi

    Internal medicine (Tokyo, Japan)   2024.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    A 59-year-old woman presented with a rash on the top part of her hands and pain in the wrist joint and was diagnosed with dermatomyositis complicated by interstitial pneumonia positive for anti-melanoma differentiation-associated gene 5 (MDA-5) antibody. However, the patient reported a severe headache following treatment with oral prednisolone and tacrolimus. Posterior reversible encephalopathy syndrome (PRES) was diagnosed based on the brain magnetic resonance imaging findings. Tacrolimus was discontinued, and mycophenolate mofetil was instead administered with a favorable outcome. Mycophenolate mofetil should therefore be considered as an alternative treatment for anti-MDA-5-positive interstitial lung disease in cases where calcineurin inhibitors cannot be used.

    DOI： 10.2169/internalmedicine.3533-24

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  • A case of eosinophilic granulomatosis with polyangiitis showing multiple white lichen lesions on the airway mucosa. International journal

    Yosuke Kimura, Ryo Ito, Yoshiki Hayashi, Toshihiro Kazawa, Yoshiro Endo, Akira Iwashima, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Toshiaki Kikuchi

    Respiratory medicine case reports   33   101451 - 101451   2021

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    A 70-year-old man, treated for asthma for 2 years and chronic sinusitis for several months, presented with fever, numbness in the lower limbs, heaviness in the head, gross hematuria, and black stools. He also had eosinophilia, elevated serum IgG4 levels, high levels of myeloperoxidase-anti-neutrophil cytoplasmic antibodies (MPO-ANCA), and pulmonary infiltrative shadows. Bronchoscopy revealed multiple white flattened lesions (white moss) on the airway mucosa, suggesting mycobacterial infection or malignancy. A biopsy from tracheal mucosa revealed airway inflammation with marked eosinophil infiltration. The patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) and treated with steroids, and all findings improved. However, a year and a half after the initiation of treatment, eosinophils and IgE gradually increased; subjective symptoms, such as asthma symptoms and numbness in the lower limbs, worsened; and ANCA, which had been negative, turned positive. Therefore, we suspected disease relapse and anti-IL-5 antibody (mepolizumab) treatment was initiated. Thereafter, ANCA turned negative again, eosinophils and IgE normalized, and subjective symptoms decreased. The presence of airway mucosal lesions in EGPA is relatively rare, and we report this case as a valuable case owing to the interesting bronchoscopic findings that are worth comprehending as a respiratory physician.

    DOI： 10.1016/j.rmcr.2021.101451

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  • The impact of mepolizumab on the sputum level of eosinophil-derived protein in three cases of severe asthma. Reviewed International journal

    Toshiyuki Koya, Yosuke Kimura, Masachika Hayashi, Takashi Hasegawa, Toshiaki Kikuchi

    Allergology international : official journal of the Japanese Society of Allergology   69 ( 4 )   639 - 641   2020.10

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  • Characterization of low adherence population in asthma patients from Japan using Adherence Starts with Knowledge-12. Reviewed International journal

    Yuka Kimura, Toshiyuki Koya, Takashi Hasegawa, Hiroshi Ueno, Kazutaka Yoshizawa, Yosuke Kimura, Masachika Hayashi, Satoshi Watanabe, Toshiaki Kikuchi

    Allergology international : official journal of the Japanese Society of Allergology   69 ( 1 )   61 - 65   2020.1

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    BACKGROUND: Adherence Starts with Knowledge-12 (ASK-12) is a useful indicator of drug adherence. In this study, we analyzed patient background including social and psychological factors in a low-adherence group of patients with asthma defined using ASK-12. METHODS: From a questionnaire survey for patients with asthma from the Niigata Prefecture, Japan, conducted in the fall of 2016, we enrolled patients who answered all ASK-12 items and underwent a measured respiratory function test within 1 year. The low-adherence group (ASK-12 ≥ 28) was compared with the control group (ASK-12 < 28), and we conducted a cluster analysis of the low-adherence group. RESULTS: There were 170 patients in the low-adherence group and 402 patients in the control group. There was a significant difference between age, gender, working status, smoking history, the percentage of forced expiratory volume in one second (%FEV1), asthma control test (ACT), and Patient Health Questionnaire-9 (PHQ-9) score between the two groups. Logistic analysis revealed that working status (working), % FEV1 (<90%), and PHQ-9 score (>5) were independent factors for the low-adherence group. The cluster analysis identified three clusters in the low-adherence group. Among these, one cluster was characterized by elderly males with chronic obstructive pulmonary disease and another by middle-aged nonsmoking females with a depression tendency, had problems with asthma control. CONCLUSIONS: Several factors were considered to be attributed to low drug-adherence. There were several phenotypes in the low-adherence population correlated with incomplete asthma control. Intervention with drug adherence should be a future goal for asthma treatment.

    DOI： 10.1016/j.alit.2019.07.006

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  • A single injection of a sustained-release prostacyclin analog (ONO-1301MS) suppresses airway inflammation and remodeling in a chronic house dust mite-induced asthma model Reviewed

    Yosuke Kimura, Toshiyuki Koya, Hiroshi Kagamu, Kenjiro Shima, Hirotaka Sakamoto, Hidenori Kawakami, Yoshifumi Hoshino, Toshiki Furukawa, Takuro Sakagami, Takashi Hasegawa, Masami Narita, Eiichi Suzuki, Ichiei Narita

    European Journal of Pharmacology   721 ( 1-3 )   80 - 85   2013.12

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    DOI： 10.1016/j.ejphar.2013.09.051

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  • 減感作療法によりロルラチニブの内服再開が可能であったALK融合遺伝子陽性肺腺癌の1例

    篠原 陽介, 鈴木 明日美, 柳村 尚寛, 有田 将史, 佐藤 美由紀, 島 賢治郎, 田中 知宏, 野嵜 幸一郎, 才田 優, 木村 陽介, 青木 信将, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明, 鈴木 紗也佳, 筒井 由夏, 林 良太

    日本呼吸器学会誌   14 ( 増刊 )   369 - 369   2025.3

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    Language：Japanese   Publisher：(一社)日本呼吸器学会  

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  • Prevalence and characteristics of dysfunctional breathing in patients with asthma in the Japanese population. International journal

    Natsuki Takeda, Toshiyuki Koya, Takashi Hasegawa, Moe Tanaka, Takahiro Matsuda, Yui Murai, Shun Naramoto, Yosuke Kimura, Kenjiro Shima, Makoto Kurokawa, Ami Aoki, Chieko Yoshida, Takuro Sakagami, Shuichiro Maruoka, Yasuhiro Gon, Toshiaki Kikuchi

    Respiratory investigation   62 ( 6 )   1015 - 1020   2024.8

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    BACKGROUND: Dysfunctional breathing (DB) is a major asthma comorbidity; however, it is not well recognized in Japan. Moreover, it has rarely been reported in the asthma population, and its clinical characteristics are unclear. We aimed to clarify the clinical characteristics of DB as a comorbidity in patients with asthma in Japan. Questionnaire surveys were conducted among patients with asthma at medical facilities in three regions of Japan (Niigata, Kumamoto, and Tokyo). METHODS: This cross-sectional questionnaire survey targeting patients with asthma who had regularly visited medical institutions and their doctors was conducted from September to November 2021. The questionnaire addressed the control status and method of treatment. The diagnosis of DB was evaluated using the Nijmegen questionnaire (NQ). RESULTS: There were 2087 eligible participants. Based on their NQ scores, 217 patients were classified into the DB group (NQ ≥ 19). There were significant differences with respect to sex, disease duration, Asthma Control Test (ACT) scores, Patient Health Questionnaire-9 (PHQ-9) scores, type-2 biomarkers, pulmonary function indices, treatment methods, severity, and asthma exacerbations in the previous year between the DB and non-DB groups. In the multivariate analysis, there were significant differences in sex, disease duration (≥15 y), ACT scores (<20), and PHQ-9 scores (≥10). The cluster analysis of cases with DB classified the population into four clusters. CONCLUSIONS: The asthma population with DB exhibited several characteristics, including depression and poorly controlled asthma. Further large-scale interventional investigations with longer follow-up periods are necessary to verify these findings.

    DOI： 10.1016/j.resinv.2024.08.004

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  • ニンテダニブによる治療にもかかわらず呼吸機能の経年低下の進行を認める強皮症関連ILDの臨床的特徴

    木村 陽介, 青木 亜美, 島 賢治郎, 穂苅 諭, 永井 明日香, 青木 信将, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   13 ( 増刊 )   246 - 246   2024.3

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    Language：Japanese   Publisher：(一社)日本呼吸器学会  

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  • Effects of Benralizumab on Three-Dimensional Computed Tomography Analysis in Severe Eosinophilic Asthma. International journal

    Fumito Tsubokawa, Toshiyuki Koya, Yui Murai, Kentaro Tanaka, Yuchi Tsutsui, Shun Naramoto, Natsumi Sakai, Ami Aoki, Kenjiro Shima, Yosuke Kimura, Satoshi Watanabe, Takashi Hasegawa, Toshiaki Kikuchi

    International archives of allergy and immunology   184 ( 3 )   243 - 251   2023

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    INTRODUCTION: Benralizumab, an anti-interleukin-5 receptor chain monoclonal antibody, is used to treat severe asthma and control asthma symptoms or exacerbations. The aim of this study was to examine the changes in airway morphology using computed tomography (CT) images in accordance with clinical efficacy following the administration of benralizumab. METHODS: The clinical efficacy of benralizumab was evaluated in 11 patients with severe asthma by analyzing the changes in parameters, such as the asthma control test, asthma quality of life questionnaire, pulmonary function, and exacerbation count. We also investigated the airway wall thickness of the right bronchus (B1) and the total airway count (TAC) using CT images. RESULTS: Most patients treated with benralizumab showed improvements in asthma symptoms and exacerbations. CT imaging analyses showed a decrease in the right B1 airway wall thickness and an increase in the TAC. Correlations between blood eosinophil count and changes in CT imaging were observed. DISCUSSION/CONCLUSION: The data suggested that benralizumab has the potential to improve airway wall thickening and ventilation by alleviating the obstruction and clearing an obstructed airway.

    DOI： 10.1159/000525846

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  • Effect of Benralizumab on Mucus Plugs in Severe Eosinophilic Asthma. International journal

    Natsumi Sakai, Toshiyuki Koya, Yui Murai, Fumito Tsubokawa, Kentaro Tanaka, Shun Naramoto, Ami Aoki, Kenjiro Shima, Yosuke Kimura, Satoshi Watanabe, Takashi Hasegawa, Toshiaki Kikuchi

    International archives of allergy and immunology   184 ( 8 )   783 - 791   2023

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    INTRODUCTION: Mucus plugs are associated with airway obstruction in severe asthma and are involved in the formation of activated eosinophils. Benralizumab, an anti-interleukin-5 receptor antibody, markedly reduces not only peripheral blood eosinophils but also airway eosinophils; however, its effects on mucus plugs have not been clarified. In this study, we examined the efficacy of benralizumab on mucus plugs using computed tomography (CT) imaging. METHODS: Twelve patients who were administered benralizumab and underwent CT before and approximately 4 months after the introduction of benralizumab were included in this study, and the number of mucus plugs before and after benralizumab administration was compared. The correlation between the clinical background and treatment effect was also examined. RESULTS: The number of mucus plugs significantly decreased after the introduction of benralizumab. The number of mucus plugs was correlated with sputum eosinophil percentage and eosinophil cationic protein in the sputum supernatants and inversely correlated with forced expiratory volume in 1 s (FEV1). Benralizumab induction resulted in a marked decrease in blood and sputum eosinophil levels and a significant improvement in asthma symptoms, quality of life scores, FEV1, and exacerbation frequency. Furthermore, there was a significant correlation between the reduction in mucus plugs and changes in the symptom score or FEV1. DISCUSSION/CONCLUSION: These data suggest that benralizumab may have the potential to improve symptoms and respiratory function in patients with severe eosinophilic asthma by reducing mucus plugs.

    DOI： 10.1159/000530392

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  • 気管支喘息(成人):疫学、バイオマーカー コロナ禍における喘息患者の実態 2021年新潟県内アンケート調査より

    木村 陽介, 村井 裕衣, 奈良本 駿, 筒井 裕一, 坪川 史人, 田中 健太郎, 青木 亜美, 島 賢治郎, 小屋 俊之, 長谷川 隆志, 菊地 利明

    アレルギー   71 ( 6-7 )   790 - 790   2022.8

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    Language：Japanese   Publisher：(一社)日本アレルギー学会  

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  • A Case Report of Occupational Lung Disease Caused by Exposure to Polytetrafluoroethylene.

    Ami Aoki, Akira Saito, Kenjiro Shima, Yosuke Kimura, Katsuaki Asakawa, Riuko Ohashi, Hajime Umezu, Takuro Sakagami, Hiroshi Moriyama, Toshiaki Kikuchi

    Internal medicine (Tokyo, Japan)   61 ( 24 )   3713 - 3717   2022.5

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    We herein report a 45-year-old-man with multiple foreign body granulomas in the lungs caused by polytetrafluoroethylene (PTFE). A mass in the right lower lobe of the lung and bilateral centrilobular lung nodules were found unexpectedly during the patient's visit to a hospital for a respiratory infection. The patient's occupation for 26 years involved spraying PTFE. A lung biopsy using bronchoscopy revealed granulomatous lesions and giant cells. The presence of fluorine in the granulomatous lesions was confirmed using an electron probe microanalyzer with wavelength dispersive spectrometer. Fluorine is a component of PTFE and is not found in normal lung tissue.

    DOI： 10.2169/internalmedicine.9008-21

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  • Two cases of dupilumab-associated eosinophilic pneumonia in asthma with eosinophilic chronic rhinosinusitis: IL-5-driven pathology? International journal

    Yuki Nishiyama, Toshiyuki Koya, Kei Nagano, Seitaro Abe, Yosuke Kimura, Kenjiro Shima, Mio Toyama-Kosaka, Takashi Hasegawa, Takanobu Sasaki, Kaori Shinbori, Shigeharu Ueki, Kaori Takamura, Toshiaki Kikuchi

    Allergology international : official journal of the Japanese Society of Allergology   71 ( 4 )   548 - 551   2022.4

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  • 気管支拡張症に合併し、動脈塞栓術で退縮が得られた気管支静脈瘤の1例

    倉科 健司, 穂苅 諭, 月岡 啓輔, 青木 信将, 木村 陽介, 林 正周, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    気管支学   43 ( 6 )   589 - 594   2021.11

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  • 気管支拡張症に合併し、動脈塞栓術で退縮が得られた気管支静脈瘤の1例

    倉科 健司, 穂苅 諭, 月岡 啓輔, 青木 信将, 木村 陽介, 林 正周, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    気管支学   43 ( 6 )   589 - 594   2021.11

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  • Effect of Dupilumab on Depression in Asthma with Eosinophilic Chronic Rhinosinusitis in the Japanese Population

    Toshiyuki Koya, Natsumi Sakai, Takanobu Sasaki, Kaori Shinbori, Asuka Nagai, Yosuke Kimura, Mio Toyama, Masachika Hayashi, Akira Saito, Yuki Nishiyama, Takashi Hasegawa, Yoshiyuki Muramatsu, Kumiko Muramatsu, Arata Horii, Toshiaki Kikuchi

    International Archives of Allergy and Immunology   1 - 9   2021.10

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    Publishing type：Research paper (scientific journal)   Publisher：S. Karger AG  

    DOI： 10.1159/000519296

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  • Comparison of cytokine profiles between anti-ARS antibody-positive interstitial lung diseases and those with anti-MDA-5 antibodies. Reviewed International journal

    Katsuaki Asakawa, Kazutaka Yoshizawa, Ami Aoki, Yosuke Kimura, Takahiro Tanaka, Kazumasa Ohashi, Masachika Hayashi, Toshiaki Kikuchi, Shinji Sato, Toshinori Takada

    Clinical rheumatology   39 ( 7 )   2171 - 2178   2020.7

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    INTRODUCTION/OBJECTIVES: Interstitial lung disease (ILD) is a significant cause of mortality among patients with dermatomyositis (DM) or polymyositis (PM). There are two subtypes of PM and DM often complicated with ILD: those with anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies and those with anti-MDA-5-associated amyopathic DM (ADM). Our aim is to clarify the inflammatory and immunological differences between the disorders. METHODS: We retrospectively collected consecutive patients with anti-ARS-ILD and those with anti-MDA-5 antibody-positive ADM-ILD. The serum concentration of 38 cytokines was measured using a cytokine panel. The relative risks for anti-MDA-5 antibody-positive ADM-ILD were examined with univariate and multivariate logistic regression models. Spearman's rank correlation coefficient was calculated between cytokine levels and clinical parameters in the disease. Levels of cytokines were compared between anti-ARS-ILD and anti-MDA-5-positive ADM-ILD patients (alive or dead) using Dunnett's test. RESULTS: Twenty-three patients with anti-ARS-ILD and the same number of patients with anti-MDA-5-positive ADM-ILD were enrolled. The anti-MDA-5 group had poor survival (p = 0.025). Univariate logistic regression models showed that eotaxin, IL-10, IP-10, and MCP-1 were associated with the diagnosis of anti-MDA-5-positive ADM-ILD. Multivariate logistic regression models revealed that IP-10 was the most significantly associated (p = 0.001). Relationship analyses showed that IL-10 had significant positive correlations with CK (r = 0.5267, p = 0.009) and ferritin (r = 0.4528, p = 0.045). A comparison of the cytokine levels found that IP-10 was elevated in both patients who were alive and patients who had died with ADM-ILD compared with the levels in those with ARS-ILD (p = 0.003 and p = 0.001, respectively). CONCLUSIONS: Anti-MDA-5-positive ADM-ILD had poorer survival than anti-ARS-ILD. IP-10 seems to be most deeply involved in the pathophysiology of anti-MDA-5-associated ADM-ILD.Key Points• To clarify differences in the inflammatory and immunological features of anti-MDA-5-positive ADM-ILD and anti-ARS-ILD, we performed an observational study to measure serum cytokine concentrations before treatment using a multiplex immunoassay system.• Multivariate logistic regression models revealed that IP-10 was associated with the most significant relative risk for ADM-ILD with anti-MDA-5 antibodies.• Levels of IP-10 were elevated considerably in anti-MDA-5-positive survivors and nonsurvivors compared with the levels in anti-ARS patients.• These results suggest that IP-10 is the most deeply involved in the pathophysiology of anti-MDA-5-positive ADM-ILD.

    DOI： 10.1007/s10067-020-04984-x

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  • Cysteinyl Leukotriene Synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling. Reviewed International journal

    Hiroshi Ueno, Toshiyuki Koya, Hiroyuki Takeuchi, Keisuke Tsukioka, Akira Saito, Yosuke Kimura, Masachika Hayashi, Satoshi Watanabe, Takashi Hasegawa, Masaaki Arakawa, Toshiaki Kikuchi

    American journal of respiratory cell and molecular biology   63 ( 1 )   57 - 66   2020.7

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    It is well known that the prevalence of asthma is higher in athletes, including Olympic athletes, than in the general population. In this study, we analyzed the mechanism of exercise-induced bronchoconstriction by using animal models of athlete asthma. Mice were made to exercise on a treadmill for a total duration of 1 week, 3 weeks, or 5 weeks. We analyzed airway responsiveness, BAL fluid, lung homogenates, and tissue histology for each period. In mice that were treated (i.e., the treatment model), treatments were administered from the fourth to the fifth week. We also collected induced sputum from human athletes with asthma and analyzed the supernatants. Airway responsiveness to methacholine was enhanced with repeated exercise stimulation, although the cell composition in BAL fluid did not change. Exercise induced hypertrophy of airway smooth muscle and subepithelial collagen deposition. Cysteinyl-leukotriene (Cys-LT) levels were significantly increased with exercise duration. Montelukast treatment significantly reduced airway hyperresponsiveness (AHR) and airway remodeling. Expression of PLA2G4 (phospholipase A2 group IV) and leukotriene C4 synthase in the airway epithelium was upregulated in the exercise model, and inhibition of PLA2 ameliorated AHR and airway remodeling, with associated lower levels of Cys-LTs. The levels of Cys-LTs in sputum from athletes did not differ between those with and without sputum eosinophilia. These data suggest that AHR and airway remodeling were caused by repeated and strenuous exercise. Cys-LTs from the airway epithelium, but not inflammatory cells, may play an important role in this mouse model.

    DOI： 10.1165/rcmb.2019-0325OC

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  • 再投与し得たオラパリブによる薬剤性肺障害の2例 Reviewed

    酒井 菜摘, 木村 陽介, 林 正周, 小屋 俊之, 榎本 隆之, 菊地 利明

    日本呼吸器学会誌   9 ( 3 )   200 - 204   2020.5

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    Authorship：Corresponding author   Language：Japanese   Publisher：(一社)日本呼吸器学会  

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  • Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids Reviewed

    Toshiki Furukawa, Takuro Sakagami, Toshiyuki Koya, Takashi Hasegawa, Hidenori Kawakami, Yosuke Kimura, Yoshifumi Hoshino, Hirotaka Sakamoto, Kenjiro Shima, Keisuke Tsukioka, Mio Toyama, Masachika Hayashi, Hiroshi Kagamu, Ei-ichi Suzuki, Ichiei Narita

    JOURNAL OF ASTHMA   52 ( 4 )   417 - 422   2015

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    DOI： 10.3109/02770903.2014.975357

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  • The Effects of All-Trans Retinoic Acid on the Induction of Oral Tolerance in a Murine Model of Bronchial Asthma Reviewed

    Hirotaka Sakamoto, Toshiyuki Koya, Keisuke Tsukioka, Kenjiro Shima, Satoshi Watanabe, Hiroshi Kagamu, Yosuke Kimura, Takuro Sakagami, Takashi Hasegawa, Eiichi Suzuki, Ichiei Narita

    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY   167 ( 3 )   167 - 176   2015

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000437326

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  • 両側副腎転移により副腎不全症状を呈した非小細胞肺癌の1例

    石川大輔, 渡部聡, 西山佑樹, 木村陽介, 才田優, 市川紘将, 堀好寿, 青木信将, 大嶋康義, 坂上拓郎, 小屋俊之, 森山寛史, 各務博, 吉澤弘久, 成田一衛

    新潟医学会雑誌   128 ( 10 )   531 - 536   2014.10

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    Language：Japanese   Publisher：新潟医学会  

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  • [A case of pulmonary Mycobacterium kansasii infection with pleural effusion, distinguished from pulmonary tuberculosis]. Reviewed

    Kimura Y, Kurosawa T, Hosaka K

    Kekkaku : [Tuberculosis]   89 ( 9 )   737 - 741   2014.9

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    Language：Japanese   Publisher：(一社)日本結核病学会  

    症例は44歳男で、5ヵ月前頃より続く咳嗽・喀痰、呼吸苦、食欲低下を主訴に近医を受診し、胸部X線・CTで両上葉背側部を中心に比較的壁の厚い空洞性病変を伴う広範なconsolidationおよび右大量胸水を認め、喀痰抗酸菌塗抹検査でGaffky 5号が判明した。Quanti FERON TB-2Gは陽性、胸水中Adenosine deaminaseは高値で、肺結核+結核性胸膜炎を強く疑い、標準的抗結核化学療法であるrifampicin(RFP)など3剤で治療を開始したが、喀痰抗酸菌PCRは結核菌、Mycobacterium avium complexとも陰性で、薬剤性肝障害もありいったん中止した。その後複数回の異なる喀痰培養で非結核性抗酸菌が検出され、DNA-DNA hybridization methodでM.kansasiiが同定されたことより、最終的に肺M.kansasii症と診断した。RFPを含む3剤併用療法を再開し、副作用や胸水再貯留は認めず、経過良好である。

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  • 早期に診断・治療し得た肺梗塞の1例

    黒澤隆行, 木村陽介, 竹本淳紀, 保坂公徳

    新潟医学会雑誌   128 ( 8 )   397 - 402   2014.8

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    Language：Japanese   Publisher：新潟医学会  

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  • 同胞内発症を認めた肝肺症候群に悪性リンパ腫を合併した1例

    黒澤隆行, 木村陽介, 竹本淳紀, 保坂公徳

    新潟医学会雑誌   128 ( 3 )   128 - 134   2014.3

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  • Cluster analysis identifies characteristic phenotypes of asthma with accelerated lung function decline Reviewed

    Takuro Sakagami, Takashi Hasegawa, Toshiyuki Koya, Toshiki Furukawa, Hidenori Kawakami, Yosuke Kimura, Yoshifumi Hoshino, Hirotaka Sakamoto, Kenjiro Shima, Hiroshi Kagamu, Ei-ichi Suzuki, Ichiei Narita

    JOURNAL OF ASTHMA   51 ( 2 )   113 - 118   2014.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3109/02770903.2013.852201

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  • 喘息治療薬についての喘息患者の関心・要望について 新潟喘息治療研究会2010年アンケート調査より

    長谷川 隆志, 小屋 俊之, 坂上 拓郎, 相澤 雅美, 会田 恵, 青木 信樹, 青木 信将, 東谷 正来, 安達 哲夫, 阿部 徹哉, 荒井 義彦, 五十嵐 謙一, 石川 直樹, 石田 晃, 石田 啓一郎, 石田 卓士, 石塚 修, 伊藤 和彦, 伊藤 一寿, 伊藤 実, 岩島 明, 岩田 文英, 内山 一晃, 榎本 克巳, 江部 達夫, 江部 佑輔, 遠藤 啓一, 遠藤 禎郎, 大西 昌之, 大貫 啓三, 大橋 和政, 大村 篤子, 大矢 聡, 岡島 正明, 岡田 潔, 岡田 雅美, 小川 智, 桶谷 典弘, 小原 竜軌, 大日方 一夫, 加澤 敏広, 金子 吉一, 金子 義伸, 蒲沢 知子, 川崎 聡, 河辺 昌哲, 木滑 孝一, 木村 陽介, 櫛谷 幸嗣, 國定 薫, 栗原 淳, 甲田 豊, 小浦 啓代, 小林 理, 小林 矩明, 小山 建一, 才田 優, 斎藤 功, 斎藤 琢磨, 斎藤 徹, 斎藤 智久, 笹川 康夫, 佐々木 一圭, 佐藤 一明, 佐藤 和弘, 佐藤 理津子, 佐藤 良司, 清水 崇, 瀬賀 弘行, 高橋 龍一, 滝沢 英昭, 田口 澄人, 田口 洋子, 張 大全, 塚田 弘樹, 筒井 奈々子, 津畑 千佳子, 手塚 貴文, 寺田 正樹, 冨樫 清朋, 外山 譲二, 永井 雅昭, 長尾 政之助, 中澤 朝生, 長澤 芳哉, 中嶋 俊明, 中嶋 治彦, 中山 秀英, 成田 淳一, 成田 昌紀, 丹羽 正之, 林 直樹, 早津 邦広, 樋浦 徹, 樋口 哲也, 藤田 純二, 布施 克也, 古川 俊貴, 星野 重幸, 星野 芳史, 細井 牧, 本田 茂, 本田 康征, 前田 和夫, 牧野 真人, 松田 正史, 松山 弘紀, 三上 理, 水澤 彰郎, 宮腰 将史, 村山 直也, 森山 裕之, 諸橋 数昭, 八木澤 久美子, 山口 義文, 山本 尚, 山本 賢, 横田 樹也, 若林 昌哉, 小柳 久美子, 小林 義昭, 佐藤 英夫, 鈴木 和夫, 原 勝人, 藤森 勝也, 吉嶺 文俊, 篠川 真由美, 成田 一衛, 鈴木 栄一, 下条 文武, 荒川 正昭, 新潟喘息治療研究会

    新薬と臨牀   62 ( 3 )   470 - 479   2013.3

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    Language：Japanese   Publisher：(株)医薬情報研究所  

    喘息治療薬についての喘息患者の関心・要望について、新潟喘息治療研究会2010年アンケート調査より検討した。参加施設は新潟県内の医療機関で、200床以上の24病院、200床未満の16病院と56の診療所であった。アンケート回収率は58.0%(4662例中2706例)であった。喘息治療薬の効果、易使用性、コスト・安全性の中では、患者は喘息治療薬の効果を最も重要視した。更に、喘息治療薬の効果に関する項目では、効果発現の早さ、効果の持続の2つともに重要視しているが、喘息症状の完全寛解については理解が乏しかった。易使用性では使用回数に関した要望が高いものの、内服・吸入といった使用経路についての関心が低かった。コスト・安全性では副作用についての要望が高かったものの、予想されたコスト面での要望は低かった。

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  • ダニ抗原誘発性マウス喘息モデルにおける舌下免疫療法の検討

    島 賢治郎, 小屋 俊之, 坂元 宏隆, 木村 陽介, 星野 芳史, 古川 俊貴, 坂上 拓郎, 長谷川 隆志, 土井 雅津代, 田原 善夫, 鈴木 栄一, 成田 一衛

    新潟県医師会報   ( 754 )   7 - 8   2013.1

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    Language：Japanese   Publisher：新潟県医師会  

    Balb/cマウスにコナヒョウダニ抗原を5週間連日点鼻投与して気管支喘息モデルを作成し、その後ダニ抗原舌下投与500μg/日投与群、5mg/日投与群、生理食塩水投与群に分けて2週間行い、再度抗原を1週間点鼻投与して舌下免疫療法モデルを作成してその有効性について検討した。ダニ抗原を舌下投与した群では、生理食塩水投与群に比べ気道過敏性と気管支肺胞洗浄液(BALF)中の好酸球が抑制され、抗原500μg投与群に比べ5mg投与群でより顕著であった。また、抗原舌下投与群ではBALF中のTh2サイトカインも抑制され、粘液産生細胞や細胞浸潤の減少が認められた。本モデルにおける舌下免疫療法は有効と考えられた。

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  • A Novel Prostacyclin Agonist Protects against Airway Hyperresponsiveness and Remodeling in Mice Reviewed

    Cristiane Yamabayashi, Toshiyuki Koya, Hiroshi Kagamu, Hidenori Kawakami, Yosuke Kimura, Toshiki Furukawa, Takuro Sakagami, Takashi Hasegawa, Yoshiki Sakai, Kunio Matsumoto, Mizuho Nakayama, Erwin W. Gelfand, Eiichi Suzuki, Ichiei Narita

    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   47 ( 2 )   170 - 177   2012.8

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    DOI： 10.1165/rcmb.2011-0350OC

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  • IL-17 eliminates therapeutic effects of oral tolerance in murine airway allergic inflammation Reviewed

    H. Kawakami, T. Koya, H. Kagamu, Y. Kimura, H. Sakamoto, C. Yamabayashi, T. Furukawa, T. Sakagami, T. Miyabayashi, T. Hasegawa, E. Suzuki, I. Narita

    CLINICAL AND EXPERIMENTAL ALLERGY   42 ( 6 )   946 - 957   2012.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1365-2222.2012.04006.x

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Research Projects

  • アレルゲン特異的舌下免疫療法における局所IgAの多面的役割について

    2020.9 - 2022.3

    System name：GSKジャパン研究助成2020

    Awarding organization：グラクソ・スミスクライン

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    Authorship：Principal investigator 

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Media Coverage

  • 医師に聞く『禁煙外来』(新型たばこ・新型コロナを含め) TV or radio program

    NST新潟総合テレビ  NST Newsタッチ  2020.9

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    Author：Myself 

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