Updated on 2024/04/20

写真a

 
Kimura Yosuke
 
Organization
University Medical and Dental Hospital Respiratory Medicine and Infectious Disease Specially Appointed Assistant Professor
Title
Specially Appointed Assistant Professor
External link

Degree

  • 博士（医学） ( 2014.3   新潟大学 )

Research Interests

  • 気管支喘息

  • 呼吸器内科

  • アレルギー

Research Areas

  • Life Science / Respiratory medicine

Research History (researchmap)

  • Niigata University   Specially Appointed Assistant Professor

    2018.8

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Research History

  • Niigata University   University Medical and Dental Hospital Respiratory Medicine and Infectious Disease   Specially Appointed Assistant Professor

    2020.4

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2018.8 - 2020.3

Education

  • Niigata University   医学部   医学科

    2000.4 - 2006.3

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Professional Memberships

  • 日本呼吸ケアリハビリテーション学会

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  • American Thoracic Society

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • THE JAPANESE RESPIRATORY SOCIETY

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  • JAPANESE SOCIETY OF ALLERGOLOGY

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  • THE JAPANESE SOCIETY FOR TUBERCULOSIS

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  • THE JAPAN SOCIETY FOR RESPIRATORY ENDOSCOPY

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  • THE JAPANESE SOCIETY OF SLEEP RESEARCH

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  • THE JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES

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Papers

  • Effect of Dupilumab on Depression in Asthma with Eosinophilic Chronic Rhinosinusitis in the Japanese Population

    Toshiyuki Koya, Natsumi Sakai, Takanobu Sasaki, Kaori Shinbori, Asuka Nagai, Yosuke Kimura, Mio Toyama, Masachika Hayashi, Akira Saito, Yuki Nishiyama, Takashi Hasegawa, Yoshiyuki Muramatsu, Kumiko Muramatsu, Arata Horii, Toshiaki Kikuchi

    International Archives of Allergy and Immunology   1 - 9   2021.10

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    Publishing type：Research paper (scientific journal)   Publisher：S. Karger AG  

    <b><i>Introduction:</i></b> Psychological disorders, such as depression, are markedly prevalent in patients with airway diseases. In this study, we assessed the effect of treatment with dupilumab, an IL-4 receptor α chain antibody, on depressive symptoms in a cohort of patients with asthma with eosinophilic chronic rhinosinusitis (ECRS). <b><i>Methods:</i></b> The study participants, diagnosed with asthma and ECRS, were assessed for symptoms and quality of life (QOL) scores for asthma and ECRS and medications. The Patient Health Questionnaire-9 (PHQ-9) scores were used to evaluate the depressive state. The depressive symptoms were compared with asthma and ECRS symptoms both at the time of initiation and after 4 months of dupilumab treatment. <b><i>Results:</i></b> Ultimately, 31 patients were included in the study. Most patients demonstrated a depressive state that was correlated with the nasal symptom score. In the evaluation 4 months after dupilumab treatment, the PHQ-9 score was significantly reduced, and the decrease was remarkable in patients whose nasal symptom score was reduced by 50% or more. Additionally, the PHQ-9 scores in patients with improved nasal and asthma symptoms were significantly reduced. <b><i>Discussion/Conclusion:</i></b> Dupilumab may improve QOL in patients with bronchial asthma with ECRS by reducing depressive symptoms through the improvement of clinical symptoms.

    DOI： 10.1159/000519296

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  • A case of eosinophilic granulomatosis with polyangiitis showing multiple white lichen lesions on the airway mucosa. International journal

    Yosuke Kimura, Ryo Ito, Yoshiki Hayashi, Toshihiro Kazawa, Yoshiro Endo, Akira Iwashima, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Toshiaki Kikuchi

    Respiratory medicine case reports   33   101451 - 101451   2021

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    Language：English  

    A 70-year-old man, treated for asthma for 2 years and chronic sinusitis for several months, presented with fever, numbness in the lower limbs, heaviness in the head, gross hematuria, and black stools. He also had eosinophilia, elevated serum IgG4 levels, high levels of myeloperoxidase-anti-neutrophil cytoplasmic antibodies (MPO-ANCA), and pulmonary infiltrative shadows. Bronchoscopy revealed multiple white flattened lesions (white moss) on the airway mucosa, suggesting mycobacterial infection or malignancy. A biopsy from tracheal mucosa revealed airway inflammation with marked eosinophil infiltration. The patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) and treated with steroids, and all findings improved. However, a year and a half after the initiation of treatment, eosinophils and IgE gradually increased; subjective symptoms, such as asthma symptoms and numbness in the lower limbs, worsened; and ANCA, which had been negative, turned positive. Therefore, we suspected disease relapse and anti-IL-5 antibody (mepolizumab) treatment was initiated. Thereafter, ANCA turned negative again, eosinophils and IgE normalized, and subjective symptoms decreased. The presence of airway mucosal lesions in EGPA is relatively rare, and we report this case as a valuable case owing to the interesting bronchoscopic findings that are worth comprehending as a respiratory physician.

    DOI： 10.1016/j.rmcr.2021.101451

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  • The impact of mepolizumab on the sputum level of eosinophil-derived protein in three cases of severe asthma. Reviewed International journal

    Toshiyuki Koya, Yosuke Kimura, Masachika Hayashi, Takashi Hasegawa, Toshiaki Kikuchi

    Allergology international : official journal of the Japanese Society of Allergology   69 ( 4 )   639 - 641   2020.10

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  • Cysteinyl Leukotriene Synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling. Reviewed International journal

    Hiroshi Ueno, Toshiyuki Koya, Hiroyuki Takeuchi, Keisuke Tsukioka, Akira Saito, Yosuke Kimura, Masachika Hayashi, Satoshi Watanabe, Takashi Hasegawa, Masaaki Arakawa, Toshiaki Kikuchi

    American journal of respiratory cell and molecular biology   63 ( 1 )   57 - 66   2020.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    It is well known that the prevalence of asthma is higher in athletes, including Olympic athletes, than in the general population. In this study, we analyzed the mechanism of exercise-induced bronchoconstriction by using animal models of athlete asthma. Mice were made to exercise on a treadmill for a total duration of 1 week, 3 weeks, or 5 weeks. We analyzed airway responsiveness, BAL fluid, lung homogenates, and tissue histology for each period. In mice that were treated (i.e., the treatment model), treatments were administered from the fourth to the fifth week. We also collected induced sputum from human athletes with asthma and analyzed the supernatants. Airway responsiveness to methacholine was enhanced with repeated exercise stimulation, although the cell composition in BAL fluid did not change. Exercise induced hypertrophy of airway smooth muscle and subepithelial collagen deposition. Cysteinyl-leukotriene (Cys-LT) levels were significantly increased with exercise duration. Montelukast treatment significantly reduced airway hyperresponsiveness (AHR) and airway remodeling. Expression of PLA2G4 (phospholipase A2 group IV) and leukotriene C4 synthase in the airway epithelium was upregulated in the exercise model, and inhibition of PLA2 ameliorated AHR and airway remodeling, with associated lower levels of Cys-LTs. The levels of Cys-LTs in sputum from athletes did not differ between those with and without sputum eosinophilia. These data suggest that AHR and airway remodeling were caused by repeated and strenuous exercise. Cys-LTs from the airway epithelium, but not inflammatory cells, may play an important role in this mouse model.

    DOI： 10.1165/rcmb.2019-0325OC

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  • A single injection of a sustained-release prostacyclin analog (ONO-1301MS) suppresses airway inflammation and remodeling in a chronic house dust mite-induced asthma model Reviewed

    Yosuke Kimura, Toshiyuki Koya, Hiroshi Kagamu, Kenjiro Shima, Hirotaka Sakamoto, Hidenori Kawakami, Yoshifumi Hoshino, Toshiki Furukawa, Takuro Sakagami, Takashi Hasegawa, Masami Narita, Eiichi Suzuki, Ichiei Narita

    European Journal of Pharmacology   721 ( 1-3 )   80 - 85   2013.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    ONO-1301, a novel prostacyclin agonist with thromboxane A2 synthase inhibitory activity, is a useful agent for ameliorating airway allergic inflammation
    however, its short-action feature implies a requirement for the frequent administration of this drug. Therefore, we investigated the effects of ONO-1301-loaded poly (d,l-lactic-co-glycolic acid) microspheres (ONO-1301MS
    to release ONO-1301 for 3 weeks) on the airway inflammation and remodeling in chronic house dust mite (HDM)-induced model. Balb/c mice were exposed to an HDM extract intranasally for 5 days/week for 5 consecutive weeks. The mice received a single subcutaneous injection of ONO-1301MS or vehicle after 3 weeks of HDM exposure, followed by 2 additional weeks of HDM exposure. Forty-eight hours after the last HDM exposure, airway hyperresponsiveness to methacholine was assessed and bronchoalveolar lavage was performed. Lung specimens were excised and stained to check for goblet cell metaplasia, airway smooth muscle hypertrophy, and submucosal fibrosis. Mice receiving ONO-1301MS showed significantly lower airway hyperresponsiveness, airway eosinophilia, and induced T helper 2 cytokine production compared with mice receiving the vehicle. Histological findings such as goblet cell metaplasia, airway smooth muscle hypertrophy, and submucosal fibrosis were decreased in ONO-1301MS-treated mice compared with vehicle-treated mice. A single administration of ONO-1301MS achieved sustained elevation of its circulating level for 3 weeks. These data suggest that a single administration of ONO-1301MS may suppress airway hyperresponsiveness, airway allergic inflammation, and development of airway remodeling in chronic HDM-induced asthma model. This agent may be effective as an anti-inflammatory and remodeling drug in the practical treatment of asthma. © 2013 Elsevier B.V. All rights reserved.

    DOI： 10.1016/j.ejphar.2013.09.051

    Web of Science

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  • がん薬物療法を受けた非結核性抗酸菌症併存悪性腫瘍の検討

    田中 知宏, 番場 祐基, 柴田 玲, 大坪 亜矢, 尾形 英至, 庄子 聡, 野嵜 幸一郎, 才田 優, 近藤 利恵, 穂苅 諭, 木村 陽介, 大嶋 康義, 茂呂 寛, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   12 ( 増刊 )   228 - 228   2023.3

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    Language：Japanese   Publisher：(一社)日本呼吸器学会  

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  • G-CSF産生能小細胞肺癌の治療成績の検討

    板垣 智也, 野嵜 幸一郎, 田中 奨, 後藤 優佳, 鈴木 遼, 大坪 亜矢, 庄子 聡, 田中 知宏, 島 賢治郎, 才田 優, 穂苅 諭, 木村 陽介, 近藤 利恵, 青木 信将, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   12 ( 増刊 )   389 - 389   2023.3

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    Language：Japanese   Publisher：(一社)日本呼吸器学会  

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  • オシメルチニブによる薬剤性肺障害の実態と治療後のEGFR遺伝子変異非小細胞肺癌に対する治療選択に関する検討

    才田 優, 田中 奨, 後藤 優佳, 鈴木 遼, 大坪 亜矢, 庄子 聡, 田中 知宏, 野嵜 幸一郎, 島 賢治郎, 穂苅 諭, 木村 陽介, 近藤 利恵, 青木 信将, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   12 ( 増刊 )   253 - 253   2023.3

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    Language：Japanese   Publisher：(一社)日本呼吸器学会  

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  • がん薬物療法を受けた非結核性抗酸菌症併存悪性腫瘍の検討

    田中 知宏, 番場 祐基, 柴田 玲, 大坪 亜矢, 尾形 英至, 庄子 聡, 野嵜 幸一郎, 才田 優, 近藤 利恵, 穂苅 諭, 木村 陽介, 大嶋 康義, 茂呂 寛, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   12 ( 増刊 )   228 - 228   2023.3

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    Language：Japanese   Publisher：(一社)日本呼吸器学会  

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  • ベンラリズマブによる粘液栓への効果

    酒井 菜摘, 小屋 俊之, 青木 亜美, 木村 陽介, 島 賢治郎, 長谷川 隆志, 青木 信将, 大嶋 康義, 渡部 聡, 菊地 利明

    日本内科学会雑誌   112 ( 臨増 )   186 - 186   2023.2

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    Language：Japanese   Publisher：(一社)日本内科学会  

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  • 分子標的薬を安全に使用できたEGFR遺伝子変異陽性肺癌合併妊娠の一例

    大坪 亜矢, 後藤 優佳, 鈴木 遼, 庄子 聡, 島 賢治郎, 田中 知宏, 野嵜 幸一郎, 才田 優, 木村 陽介, 穂苅 諭, 近藤 利恵, 青木 信将, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明, 清水 圭太, 生野 寿史, 石田 卓士, 三浦 昌朋

    肺癌   62 ( 6 )   725 - 725   2022.11

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    Language：Japanese   Publisher：(NPO)日本肺癌学会  

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  • 小細胞肺癌に転化したEGFR遺伝子変異陽性肺腺癌に対してABCP療法を行った1例

    野嵜 幸一郎, 後藤 優佳, 鈴木 遼, 大坪 亜矢, 庄子 聡, 田中 知宏, 才田 優, 近藤 利恵, 島 賢治郎, 木村 陽介, 青木 信将, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    肺癌   62 ( 6 )   783 - 783   2022.11

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    Language：Japanese   Publisher：(NPO)日本肺癌学会  

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  • 免疫チェックポイント阻害薬が著効した肺紡錘細胞癌の2例

    鈴木 遼, 庄子 聡, 藤崎 俊哉, 大坪 亜矢, 野嵜 幸一郎, 田中 知宏, 才田 優, 近藤 利恵, 島 賢治郎, 木村 陽介, 青木 信将, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    肺癌   62 ( 6 )   791 - 791   2022.11

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    Language：Japanese   Publisher：(NPO)日本肺癌学会  

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  • A Case Report of Occupational Lung Disease Caused by Exposure to Polytetrafluoroethylene.

    Ami Aoki, Akira Saito, Kenjiro Shima, Yosuke Kimura, Katsuaki Asakawa, Riuko Ohashi, Hajime Umezu, Takuro Sakagami, Hiroshi Moriyama, Toshiaki Kikuchi

    Internal medicine (Tokyo, Japan)   2022.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    We herein report a 45-year-old-man with multiple foreign body granulomas in the lungs caused by polytetrafluoroethylene (PTFE). A mass in the right lower lobe of the lung and bilateral centrilobular lung nodules were found unexpectedly during the patient's visit to a hospital for a respiratory infection. The patient's occupation for 26 years involved spraying PTFE. A lung biopsy using bronchoscopy revealed granulomatous lesions and giant cells. The presence of fluorine in the granulomatous lesions was confirmed using an electron probe microanalyzer with wavelength dispersive spectrometer. Fluorine is a component of PTFE and is not found in normal lung tissue.

    DOI： 10.2169/internalmedicine.9008-21

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  • Two cases of dupilumab-associated eosinophilic pneumonia in asthma with eosinophilic chronic rhinosinusitis: IL-5-driven pathology? International journal

    Yuki Nishiyama, Toshiyuki Koya, Kei Nagano, Seitaro Abe, Yosuke Kimura, Kenjiro Shima, Mio Toyama-Kosaka, Takashi Hasegawa, Takanobu Sasaki, Kaori Shinbori, Shigeharu Ueki, Kaori Takamura, Toshiaki Kikuchi

    Allergology international : official journal of the Japanese Society of Allergology   71 ( 4 )   548 - 551   2022.4

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  • 一次治療としてオシメルチニブを使用したEGFR遺伝子変異陽性扁平上皮肺癌の検討

    後藤 優佳, 大坪 亜矢, 久代 航平, 庄子 聡, 田中 知宏, 野嵜 幸一郎, 才田 優, 近藤 利恵, 島 賢治郎, 木村 陽介, 青木 信将, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   11 ( 増刊 )   178 - 178   2022.4

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  • オシメルチニブによる肺血栓塞栓症を発症した非小細胞肺癌3例の検討

    藤崎 俊哉, 庄子 聡, 渡部 聡, 才田 優, 島 賢治郎, 木村 陽介, 青木 信将, 大嶋 康義, 小屋 俊之, 菊地 利明

    日本内科学会雑誌   111 ( 臨増 )   203 - 203   2022.2

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  • 気管支拡張症に合併し、動脈塞栓術で退縮が得られた気管支静脈瘤の1例

    倉科 健司, 穂苅 諭, 月岡 啓輔, 青木 信将, 木村 陽介, 林 正周, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    気管支学   43 ( 6 )   589 - 594   2021.11

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    Language：Japanese   Publisher：(NPO)日本呼吸器内視鏡学会  

    背景.気管支静脈瘤は稀な疾患であり,その治療法は確立されていない.症例.78歳,女性.小児期より気管支拡張症を罹患し,膿胸の既往があった.6年前から喀血を繰り返し,計3回の気管支動脈塞栓術が行われていた.今回,喀血を契機に入院し,止血薬投与を受けたが大量喀血を来したため,気管挿管の上で人工呼吸管理となった.左下横隔動脈と左気管支動脈をゼラチンスポンジで塞栓し,止血を得た.その際の選択的動脈造影で左下横隔動脈と肺静脈との動静脈シャントを認めた.気管支鏡で観察すると,左上下葉支分岐部に気管支静脈瘤がみられ,出血源と考えられた.動脈塞栓術の2週後の気管支鏡では同部位の瘤は退縮していた.その後,再喀血なく自宅退院した.結論.気管支静脈瘤は気管支拡張症や動脈塞栓に関連して発症する可能性があり,喀血時は気管支鏡による確認が必要である.治療として異常シャントの塞栓術が有効と考えられた.(著者抄録)

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    Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J00298&link_issn=&doc_id=20211216270004&doc_link_id=%2Fcf0brond%2F2021%2F004306%2F005%2F0589-0594%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcf0brond%2F2021%2F004306%2F005%2F0589-0594%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 気管支拡張症に合併し、動脈塞栓術で退縮が得られた気管支静脈瘤の1例

    倉科 健司, 穂苅 諭, 月岡 啓輔, 青木 信将, 木村 陽介, 林 正周, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    気管支学   43 ( 6 )   589 - 594   2021.11

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  • 非小細胞肺癌に対するアテゾリズマブ/カルボプラチン/パクリタキセル/ベバシズマブ療法の後方視的解析

    庄子 聡, 渡部 聡, 大坪 亜矢, 野嵜 幸一郎, 田中 知宏, 才田 優, 近藤 利恵, 木村 陽介, 青木 信将, 大嶋 康義, 小屋 俊之, 菊地 利明

    肺癌   61 ( 6 )   696 - 696   2021.10

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  • 非小細胞肺癌に対するアテゾリズマブ/カルボプラチン/パクリタキセル/ベバシズマブ療法の後方視的解析

    庄子 聡, 渡部 聡, 大坪 亜矢, 野嵜 幸一郎, 田中 知宏, 才田 優, 近藤 利恵, 木村 陽介, 青木 信将, 大嶋 康義, 小屋 俊之, 菊地 利明

    肺癌   61 ( 6 )   696 - 696   2021.10

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  • 造血器悪性腫瘍に対するチロシンキナーゼ阻害薬が発症原因と考えられた自己免疫性肺胞蛋白症の2例

    木村 陽介, 野嵜 幸一郎, 市川 紘将, 永井 明日香, 青木 信将, 林 正周, 大嶋 康義, 近藤 利恵, 渡部 聡, 小屋 俊之, 菊地 利明

    気管支学   43 ( Suppl. )   S285 - S285   2021.6

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  • Comparison of cytokine profiles between anti-ARS antibody-positive interstitial lung diseases and those with anti-MDA-5 antibodies. Reviewed International journal

    Katsuaki Asakawa, Kazutaka Yoshizawa, Ami Aoki, Yosuke Kimura, Takahiro Tanaka, Kazumasa Ohashi, Masachika Hayashi, Toshiaki Kikuchi, Shinji Sato, Toshinori Takada

    Clinical rheumatology   39 ( 7 )   2171 - 2178   2020.7

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    INTRODUCTION/OBJECTIVES: Interstitial lung disease (ILD) is a significant cause of mortality among patients with dermatomyositis (DM) or polymyositis (PM). There are two subtypes of PM and DM often complicated with ILD: those with anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies and those with anti-MDA-5-associated amyopathic DM (ADM). Our aim is to clarify the inflammatory and immunological differences between the disorders. METHODS: We retrospectively collected consecutive patients with anti-ARS-ILD and those with anti-MDA-5 antibody-positive ADM-ILD. The serum concentration of 38 cytokines was measured using a cytokine panel. The relative risks for anti-MDA-5 antibody-positive ADM-ILD were examined with univariate and multivariate logistic regression models. Spearman's rank correlation coefficient was calculated between cytokine levels and clinical parameters in the disease. Levels of cytokines were compared between anti-ARS-ILD and anti-MDA-5-positive ADM-ILD patients (alive or dead) using Dunnett's test. RESULTS: Twenty-three patients with anti-ARS-ILD and the same number of patients with anti-MDA-5-positive ADM-ILD were enrolled. The anti-MDA-5 group had poor survival (p = 0.025). Univariate logistic regression models showed that eotaxin, IL-10, IP-10, and MCP-1 were associated with the diagnosis of anti-MDA-5-positive ADM-ILD. Multivariate logistic regression models revealed that IP-10 was the most significantly associated (p = 0.001). Relationship analyses showed that IL-10 had significant positive correlations with CK (r = 0.5267, p = 0.009) and ferritin (r = 0.4528, p = 0.045). A comparison of the cytokine levels found that IP-10 was elevated in both patients who were alive and patients who had died with ADM-ILD compared with the levels in those with ARS-ILD (p = 0.003 and p = 0.001, respectively). CONCLUSIONS: Anti-MDA-5-positive ADM-ILD had poorer survival than anti-ARS-ILD. IP-10 seems to be most deeply involved in the pathophysiology of anti-MDA-5-associated ADM-ILD.Key Points• To clarify differences in the inflammatory and immunological features of anti-MDA-5-positive ADM-ILD and anti-ARS-ILD, we performed an observational study to measure serum cytokine concentrations before treatment using a multiplex immunoassay system.• Multivariate logistic regression models revealed that IP-10 was associated with the most significant relative risk for ADM-ILD with anti-MDA-5 antibodies.• Levels of IP-10 were elevated considerably in anti-MDA-5-positive survivors and nonsurvivors compared with the levels in anti-ARS patients.• These results suggest that IP-10 is the most deeply involved in the pathophysiology of anti-MDA-5-positive ADM-ILD.

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  • 再投与し得たオラパリブによる薬剤性肺障害の2例 Reviewed

    酒井 菜摘, 木村 陽介, 林 正周, 小屋 俊之, 榎本 隆之, 菊地 利明

    日本呼吸器学会誌   9 ( 3 )   200 - 204   2020.5

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    オラパリブ(olaparib)は、進行卵巣癌・乳癌に対する新規の分子標的薬(poly ADP-ribose polymerase阻害薬)である。オラパリブによる薬剤性肺障害の発症頻度は低いとされているが、当院ではオラパリブによる薬剤性肺障害と思われる症例を2例経験した。発症時期、症状、経過、検査所見など多くの共通点がみられた一方、画像パターンには一定の傾向はみられなかった。原疾患が悪性腫瘍の場合、再投与の可否が問題となるが、本例では2例とも再燃を認めずに再投与し得た。今後オラパリブは適応が広まっていくことが予想されており、薬剤性肺障害にも留意する必要がある。(著者抄録)

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  • Characterization of low adherence population in asthma patients from Japan using Adherence Starts with Knowledge-12. Reviewed International journal

    Yuka Kimura, Toshiyuki Koya, Takashi Hasegawa, Hiroshi Ueno, Kazutaka Yoshizawa, Yosuke Kimura, Masachika Hayashi, Satoshi Watanabe, Toshiaki Kikuchi

    Allergology international : official journal of the Japanese Society of Allergology   69 ( 1 )   61 - 65   2020.1

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    BACKGROUND: Adherence Starts with Knowledge-12 (ASK-12) is a useful indicator of drug adherence. In this study, we analyzed patient background including social and psychological factors in a low-adherence group of patients with asthma defined using ASK-12. METHODS: From a questionnaire survey for patients with asthma from the Niigata Prefecture, Japan, conducted in the fall of 2016, we enrolled patients who answered all ASK-12 items and underwent a measured respiratory function test within 1 year. The low-adherence group (ASK-12 ≥ 28) was compared with the control group (ASK-12 < 28), and we conducted a cluster analysis of the low-adherence group. RESULTS: There were 170 patients in the low-adherence group and 402 patients in the control group. There was a significant difference between age, gender, working status, smoking history, the percentage of forced expiratory volume in one second (%FEV1), asthma control test (ACT), and Patient Health Questionnaire-9 (PHQ-9) score between the two groups. Logistic analysis revealed that working status (working), % FEV1 (<90%), and PHQ-9 score (>5) were independent factors for the low-adherence group. The cluster analysis identified three clusters in the low-adherence group. Among these, one cluster was characterized by elderly males with chronic obstructive pulmonary disease and another by middle-aged nonsmoking females with a depression tendency, had problems with asthma control. CONCLUSIONS: Several factors were considered to be attributed to low drug-adherence. There were several phenotypes in the low-adherence population correlated with incomplete asthma control. Intervention with drug adherence should be a future goal for asthma treatment.

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  • Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids Reviewed

    Toshiki Furukawa, Takuro Sakagami, Toshiyuki Koya, Takashi Hasegawa, Hidenori Kawakami, Yosuke Kimura, Yoshifumi Hoshino, Hirotaka Sakamoto, Kenjiro Shima, Keisuke Tsukioka, Mio Toyama, Masachika Hayashi, Hiroshi Kagamu, Ei-ichi Suzuki, Ichiei Narita

    JOURNAL OF ASTHMA   52 ( 4 )   417 - 422   2015

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    Objective: Eosinophilic inflammation in the respiratory tract is a hallmark of bronchial asthma. In naive cases, the inflammatory profile is associated with disease severity and reactivity to inhaled corticosteroids (ICS). Sustained airway eosinophilia has been reported during ICS treatment. However, the immunological characteristics of these cases are not known and it is unclear if this situation contributes to asthma control. This study was performed to determine the answer of these questions. Methods: To compare phenotypes of eosinophilic and non-eosinophilic asthma (EA and NEA, respectively) under ICS treatment, clinical data were obtained from asthmatic subjects (n = 22) and healthy controls (n = 10), and the leukocyte compositions of induced sputum and peripheral blood were determined. T lymphocyte profiles in systemic blood were assessed by flow cytometry. Results: A higher frequency of emergency room visits was observed in the NEA group, which had a higher neutrophil count relative to the total inflammatory cell population in induced sputum than the EA group (59.5 versus 36.6%; p&lt;0.01). The fraction of helper T (Th)17 lymphocytes as well as the ratio of Th17 to regulatory T cells (Treg) in the peripheral blood was higher in the NEA than in the EA group (0.24 versus 0.13; p&lt;0.05). Conclusions: Th17 were more prevalent than Treg cells in the peripheral blood of NEA patients under ICS treatment, corresponding to neutrophil-dominant airway inflammation and a severe asthmatic phenotype. Thus, an imbalance in Th17/Treg may be associated with the pathogenesis of NEA in patients undergoing ICS treatment.

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  • The Effects of All-Trans Retinoic Acid on the Induction of Oral Tolerance in a Murine Model of Bronchial Asthma Reviewed

    Hirotaka Sakamoto, Toshiyuki Koya, Keisuke Tsukioka, Kenjiro Shima, Satoshi Watanabe, Hiroshi Kagamu, Yosuke Kimura, Takuro Sakagami, Takashi Hasegawa, Eiichi Suzuki, Ichiei Narita

    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY   167 ( 3 )   167 - 176   2015

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    Background: Active suppression induced by regulatory T (Treg) cells is reported to be one of the mechanisms involved in oral tolerance. All-trans retinoic acid (ATRA) has been reported to affect Treg cell differentiation. The present study examined the effects of ATRA on the induction of oral tolerance in a murine model of bronchial asthma. Methods: BALB/c mice were sensitized to and challenged with ovalbumin (OVA) through feeding followed by OVA challenges. In some study groups ATRA was orally administered concomitantly with OVA feeding either in the presence or absence of the retinoic acid receptor antagonist LE135. Lung CD4(+) T cells were isolated from mice exposed to ATRA and/or OVA, and transferred to control mice. Airway hyperresponsiveness (AHR), cell counts and cytokine levels in bronchoalveolar lavage (BAL) fluid, and lung histology were assessed. Results: Concomitant administration of ATRA with OVA ameliorated AHR, airway eosinophilia, elevation of cytokines in BAL fluid and goblet cell metaplasia. The proportion of Treg cells in the lungs was increased in mice treated with OVA and ATRA, as compared to those treated with OVA only. Transfer of lung CD4(+) T cells from mice treated with OVA and ATRA induced suppression of AHR and airway inflammation. LE135 completely reversed the effects of ATRA on AHR, airway allergic inflammation and the number of Treg cells in the lungs. Conclusion: These data suggested that oral administration of ATRA with OVA had the potential to enhance oral tolerance in this murine model of bronchial asthma. These effects were mediated, at least in part, by Treg cell expansion. (C) 2015 S. Karger AG, Basel

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  • 両側副腎転移により副腎不全症状を呈した非小細胞肺癌の1例

    石川大輔, 渡部聡, 西山佑樹, 木村陽介, 才田優, 市川紘将, 堀好寿, 青木信将, 大嶋康義, 坂上拓郎, 小屋俊之, 森山寛史, 各務博, 吉澤弘久, 成田一衛

    新潟医学会雑誌   128 ( 10 )   531 - 536   2014.10

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    症例は54歳、男性。非小細胞肺癌(腺癌)、stage IV、上皮成長受容体遺伝子変異陽性と診断された。3次化学療法目的に入院した際、発熱、嘔気、低ナトリウム血症などの症状を認められた。血中コルチゾル低値、血中ACTH高値などから、急性副腎不全と診断した。両側副腎に巨大な肺癌の転移巣を認めており、副腎不全の原因と考えられた。ヒドロコルチゾン投与で症状は速やかに軽快した。肺癌は高率に副腎転移を来すが、両側副腎転移により副腎不全に至った報告例は少ない。我々は肺癌の両側副腎転移により副腎不全を来し、ステロイドホルモン補充により化学療法を再開しえた症例を経験したため、文献的考察を加え報告する。(著者抄録)

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  • [A case of pulmonary Mycobacterium kansasii infection with pleural effusion, distinguished from pulmonary tuberculosis]. Reviewed

    Kimura Y, Kurosawa T, Hosaka K

    Kekkaku : [Tuberculosis]   89 ( 9 )   737 - 741   2014.9

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    Language：Japanese   Publisher：(一社)日本結核病学会  

    症例は44歳男で、5ヵ月前頃より続く咳嗽・喀痰、呼吸苦、食欲低下を主訴に近医を受診し、胸部X線・CTで両上葉背側部を中心に比較的壁の厚い空洞性病変を伴う広範なconsolidationおよび右大量胸水を認め、喀痰抗酸菌塗抹検査でGaffky 5号が判明した。Quanti FERON TB-2Gは陽性、胸水中Adenosine deaminaseは高値で、肺結核+結核性胸膜炎を強く疑い、標準的抗結核化学療法であるrifampicin(RFP)など3剤で治療を開始したが、喀痰抗酸菌PCRは結核菌、Mycobacterium avium complexとも陰性で、薬剤性肝障害もありいったん中止した。その後複数回の異なる喀痰培養で非結核性抗酸菌が検出され、DNA-DNA hybridization methodでM.kansasiiが同定されたことより、最終的に肺M.kansasii症と診断した。RFPを含む3剤併用療法を再開し、副作用や胸水再貯留は認めず、経過良好である。

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  • 早期に診断・治療し得た肺梗塞の1例

    黒澤隆行, 木村陽介, 竹本淳紀, 保坂公徳

    新潟医学会雑誌   128 ( 8 )   397 - 402   2014.8

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    症例は79歳、男性。右背部痛と血痰を主訴に当科を受診した。胸部CT検査で右下葉末梢に不整な浸潤影と少量の胸水を認めた。造影CT検査で浸潤影の領域を支配する右肺動脈区域枝と右膝窩静脈に造影欠損を認めたため、急性肺血栓塞栓症、肺梗塞および深部静脈血栓症と診断した。抗凝固療法の開始により、肺動脈および下肢静脈内の血栓は消失し、右下葉胸膜下の浸潤影も縮小した。肺梗塞の早期診断・治療には、造影CT検査を積極的に行うことが重要と考えられた。(著者抄録)

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  • 同胞内発症を認めた肝肺症候群に悪性リンパ腫を合併した1例

    黒澤隆行, 木村陽介, 竹本淳紀, 保坂公徳

    新潟医学会雑誌   128 ( 3 )   128 - 134   2014.3

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  • Cluster analysis identifies characteristic phenotypes of asthma with accelerated lung function decline Reviewed

    Takuro Sakagami, Takashi Hasegawa, Toshiyuki Koya, Toshiki Furukawa, Hidenori Kawakami, Yosuke Kimura, Yoshifumi Hoshino, Hirotaka Sakamoto, Kenjiro Shima, Hiroshi Kagamu, Ei-ichi Suzuki, Ichiei Narita

    JOURNAL OF ASTHMA   51 ( 2 )   113 - 118   2014.3

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：INFORMA HEALTHCARE  

    Objective: While the majority of individuals with asthma retain normal lung function over time, some exhibit accelerated lung function decline. Preservation of lung function is an important aspect of asthma management. Whether the asthma guidelines can prevent lung function decline remains controversial. This study was performed to determine the distribution of asthmatic subjects with greater lung function decline and to identify characteristic clinical features of such subjects treated in accordance with clinical guidelines by using hierarchical cluster analysis. Methods: Eighty-six asthmatic subjects without a history of smoking were assessed with respect to eight variables selected from clinical phenotypes by using step-wise multiple regression analysis. Hierarchical cluster analysis using Ward's method generated a dendrogram for estimation of the number of clusters within the population and the differences between them. Results: Three distinct clusters were identified. Cluster 1 (n = 40) comprised women with late-onset asthma. Cluster 2 (n = 17) comprised subjects with early-onset asthma, atopy and long disease duration. Cluster 3 (n = 29) predominantly comprised older men who had late-onset asthma, a lower prevalence of exacerbation and a lower predicted % forced expiratory volume in 1 s (FEV1) at baseline. Subjects in cluster 3 showed a mean decline in FEV1 of 69 mL/year, which was the greatest lung function decline among the three clusters. Conclusion: We identified a subgroup of patients with accelerated lung function decline despite appropriate asthma treatment based on guidelines constructed by using subjective symptoms.

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  • 喘息治療薬についての喘息患者の関心・要望について 新潟喘息治療研究会2010年アンケート調査より

    長谷川 隆志, 小屋 俊之, 坂上 拓郎, 相澤 雅美, 会田 恵, 青木 信樹, 青木 信将, 東谷 正来, 安達 哲夫, 阿部 徹哉, 荒井 義彦, 五十嵐 謙一, 石川 直樹, 石田 晃, 石田 啓一郎, 石田 卓士, 石塚 修, 伊藤 和彦, 伊藤 一寿, 伊藤 実, 岩島 明, 岩田 文英, 内山 一晃, 榎本 克巳, 江部 達夫, 江部 佑輔, 遠藤 啓一, 遠藤 禎郎, 大西 昌之, 大貫 啓三, 大橋 和政, 大村 篤子, 大矢 聡, 岡島 正明, 岡田 潔, 岡田 雅美, 小川 智, 桶谷 典弘, 小原 竜軌, 大日方 一夫, 加澤 敏広, 金子 吉一, 金子 義伸, 蒲沢 知子, 川崎 聡, 河辺 昌哲, 木滑 孝一, 木村 陽介, 櫛谷 幸嗣, 國定 薫, 栗原 淳, 甲田 豊, 小浦 啓代, 小林 理, 小林 矩明, 小山 建一, 才田 優, 斎藤 功, 斎藤 琢磨, 斎藤 徹, 斎藤 智久, 笹川 康夫, 佐々木 一圭, 佐藤 一明, 佐藤 和弘, 佐藤 理津子, 佐藤 良司, 清水 崇, 瀬賀 弘行, 高橋 龍一, 滝沢 英昭, 田口 澄人, 田口 洋子, 張 大全, 塚田 弘樹, 筒井 奈々子, 津畑 千佳子, 手塚 貴文, 寺田 正樹, 冨樫 清朋, 外山 譲二, 永井 雅昭, 長尾 政之助, 中澤 朝生, 長澤 芳哉, 中嶋 俊明, 中嶋 治彦, 中山 秀英, 成田 淳一, 成田 昌紀, 丹羽 正之, 林 直樹, 早津 邦広, 樋浦 徹, 樋口 哲也, 藤田 純二, 布施 克也, 古川 俊貴, 星野 重幸, 星野 芳史, 細井 牧, 本田 茂, 本田 康征, 前田 和夫, 牧野 真人, 松田 正史, 松山 弘紀, 三上 理, 水澤 彰郎, 宮腰 将史, 村山 直也, 森山 裕之, 諸橋 数昭, 八木澤 久美子, 山口 義文, 山本 尚, 山本 賢, 横田 樹也, 若林 昌哉, 小柳 久美子, 小林 義昭, 佐藤 英夫, 鈴木 和夫, 原 勝人, 藤森 勝也, 吉嶺 文俊, 篠川 真由美, 成田 一衛, 鈴木 栄一, 下条 文武, 荒川 正昭, 新潟喘息治療研究会

    新薬と臨牀   62 ( 3 )   470 - 479   2013.3

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    喘息治療薬についての喘息患者の関心・要望について、新潟喘息治療研究会2010年アンケート調査より検討した。参加施設は新潟県内の医療機関で、200床以上の24病院、200床未満の16病院と56の診療所であった。アンケート回収率は58.0%(4662例中2706例)であった。喘息治療薬の効果、易使用性、コスト・安全性の中では、患者は喘息治療薬の効果を最も重要視した。更に、喘息治療薬の効果に関する項目では、効果発現の早さ、効果の持続の2つともに重要視しているが、喘息症状の完全寛解については理解が乏しかった。易使用性では使用回数に関した要望が高いものの、内服・吸入といった使用経路についての関心が低かった。コスト・安全性では副作用についての要望が高かったものの、予想されたコスト面での要望は低かった。

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  • ダニ抗原誘発性マウス喘息モデルにおける舌下免疫療法の検討

    島 賢治郎, 小屋 俊之, 坂元 宏隆, 木村 陽介, 星野 芳史, 古川 俊貴, 坂上 拓郎, 長谷川 隆志, 土井 雅津代, 田原 善夫, 鈴木 栄一, 成田 一衛

    新潟県医師会報   ( 754 )   7 - 8   2013.1

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    Balb/cマウスにコナヒョウダニ抗原を5週間連日点鼻投与して気管支喘息モデルを作成し、その後ダニ抗原舌下投与500μg/日投与群、5mg/日投与群、生理食塩水投与群に分けて2週間行い、再度抗原を1週間点鼻投与して舌下免疫療法モデルを作成してその有効性について検討した。ダニ抗原を舌下投与した群では、生理食塩水投与群に比べ気道過敏性と気管支肺胞洗浄液(BALF)中の好酸球が抑制され、抗原500μg投与群に比べ5mg投与群でより顕著であった。また、抗原舌下投与群ではBALF中のTh2サイトカインも抑制され、粘液産生細胞や細胞浸潤の減少が認められた。本モデルにおける舌下免疫療法は有効と考えられた。

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  • A Novel Prostacyclin Agonist Protects against Airway Hyperresponsiveness and Remodeling in Mice Reviewed

    Cristiane Yamabayashi, Toshiyuki Koya, Hiroshi Kagamu, Hidenori Kawakami, Yosuke Kimura, Toshiki Furukawa, Takuro Sakagami, Takashi Hasegawa, Yoshiki Sakai, Kunio Matsumoto, Mizuho Nakayama, Erwin W. Gelfand, Eiichi Suzuki, Ichiei Narita

    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   47 ( 2 )   170 - 177   2012.8

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    Airway remodeling in bronchial asthma results from chronic, persistent airway inflammation. The effects of the reversal of airway remodeling by drug interventions remain to be elucidated. We investigated the effects of ONO-1301, a novel prostacyclin agonist with thromboxane inhibitory activity, on the prevention and reversibility of airway remodeling in an experimental chronic asthma model. Mice sensitized and challenged to ovalbumin (OVA) three times a week for 5 consecutive weeks were administered ONO-1301 or vehicle twice a day from the fourth week of OVA challenges. Twenty-four hours after the final OVA challenge, airway hyperresponsiveness (AHR) was assessed, and bronchoalveolar lavage was performed. Lung specimens were excised for staining to detect goblet-cell metaplasia, airway smooth muscle, and submucosal fibrosis. Mice administered ONO-1301 showed limited increases in AHR compared with mice administered the vehicle. The histological findings of airway remodeling were improved in ONO-1301-treated mice compared with vehicle-treated mice. Presumably, these therapeutic effects of ONO-1301 are attributable to the up-regulation of production of hepatocyte growth factor (HGF) in lung tissue, because the neutralization of HGF by antibodies prevented the effects of ONO-1301 on AHR and airway remodeling. Mice administered ONO-1301 showed similar levels of AHR and airway remodeling as mice administered montelukast, a cysteinyl-leukotriene-1 receptor antagonist, and lower levels were observed in mice administered dexamethasone. These data suggest that ONO-1301 exerts the effect of reversing airway remodeling, at least in part through an elevation of HGF in the lungs, and may be effective as an anti-remodeling drug in the treatment of asthma.

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  • IL-17 eliminates therapeutic effects of oral tolerance in murine airway allergic inflammation Reviewed

    H. Kawakami, T. Koya, H. Kagamu, Y. Kimura, H. Sakamoto, C. Yamabayashi, T. Furukawa, T. Sakagami, T. Miyabayashi, T. Hasegawa, E. Suzuki, I. Narita

    CLINICAL AND EXPERIMENTAL ALLERGY   42 ( 6 )   946 - 957   2012.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    Background Oral tolerance is a classically used strategy for antigen-specific systemic immunotherapy. However, the roles of IL-17 in modification of oral tolerance are not yet understood.
    Objective To define the effects of IL-17 on the modification of oral tolerance, the effects of transfer of Th17 cells, administration of IL-17 or anti-IL-17 antibody (alpha IL-17Ab) to a murine allergic airway inflammation model were investigated.
    Methods Mice sensitized to and challenged with OVA, received OVA feeding, followed by OVA challenges. Transfer of Th17 cells, administration of IL-17 or alpha IL-17Ab were executed during OVA feeding. Airway hyperresponsiveness (AHR), airway inflammation, Th2 cytokine response and lung pathology were assessed.
    Results Administration of IL-17 as well as transfer of Th17 cells aggravated AHR and airway allergic inflammation as compared with the findings in mice subjected to OVA feeding alone, whereas administration of aIL-17Ab ameliorated AHR and airway eosinophilia. The effects of Th17 transfer were presumably attributable to augmentation of endogenous IL-6 production in gut. The number of Foxp3-positive regulatory T (Treg) cells in lungs and Payer's patches was increased in the OVA fed mice, whereas the number of these cells was decreased in the mice subjected to OVA feeding + Th17 cell transfer. Neutralization of IL-6 by monoclonal antibody in the mice subjected to OVA feeding + transfer of Th17 cells restored the effects of oral tolerance.
    Conclusions and Clinical Relevance These data suggest that IL-17 may inhibit the induction of tolerance to antigen through, at least in part augmenting IL-6 production, thereby suppressing the expansion of Treg cells.

    DOI： 10.1111/j.1365-2222.2012.04006.x

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  • O9-4 マウス気管支喘息経口免疫寛容モデルにおける全トランス型レチノイン酸(ATRA)の影響についての検討(O9 動物モデル,口演,第61回日本アレルギー学会秋季学術大会)

    坂元 宏隆, 小屋 俊之, 木村 陽介, 星野 芳史, 河上 英則, 古川 俊貴, 坂上 拓郎, 長谷川 隆志, 鈴木 栄一, 成田 一衛

    アレルギー   60 ( 9 )   1373 - 1373   2011

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.60.1373_4

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  • O1-3 気管支喘息患者における誘発喀痰細胞分画による気道炎症パターンと,末梢血ヘルパーT細胞バランスの相関(O1 気管支喘息 病態生理1臨床,口演,第61回日本アレルギー学会秋季学術大会)

    古川 俊貴, 坂元 宏隆, 木村 陽介, 星野 芳史, 河上 英則, 坂上 拓郎, 小屋 俊之, 長谷川 隆志, 鈴木 栄一, 成田 一衛

    アレルギー   60 ( 9 )   1361 - 1361   2011

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.60.1361_3

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  • O47-5 ダニ誘発マウス喘息モデルにおけるONO-1301の喘息抑制効果の検討(O47 免疫療法・アレルギー治療薬,口演,第61回日本アレルギー学会秋季学術大会)

    木村 陽介, 小屋 俊之, 坂元 宏隆, 河上 英則, 星野 芳史, 古川 俊貴, 坂上 拓郎, 長谷川 隆志, 酒井 芳紀, 松本 邦夫, 鈴木 栄一, 成田 一衛

    アレルギー   60 ( 9 )   1433 - 1433   2011

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.60.1433_4

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  • P1-8-7 当科におけるアスリート喘息患者の検討(P1-8気管支喘息管理,一般演題,第22回日本アレルギー学会春季臨床大会)

    星野 芳史, 小屋 俊之, 木村 陽介, 河上 英則, 滝口 朝子, 田中 純太, 長谷川 隆志, 荒川 正昭, 成田 一衛

    アレルギー   59 ( 3 )   392 - 392   2010

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.59.392_2

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  • O13-5 当科におけるアスリート喘息患者の治療効果の検討(O13 統計・疫学,口演,第60回日本アレルギー学会秋季学術大会)

    星野 芳史, 小屋 俊之, 木村 陽介, 河上 英則, 古川 俊貴, 滝口 朝子, 田中 純太, 長谷川 隆志, 荒川 正昭, 成田 一衛

    アレルギー   59 ( 9 )   1383 - 1383   2010

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.59.1383_1

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  • P3-6 TX合成酵素阻害作用を併せ持つPGI2アゴニストのダニ誘発マウス喘息モデルにおける喘息抑制効果の検討(P3 動物モデル,ポスター,第60回日本アレルギー学会秋季学術大会)

    木村 陽介, 小屋 俊之, 星野 芳史, 河上 英則, 古川 俊貴, 長谷川 隆志, 酒井 芳紀, 鈴木 栄一, 成田 一衛

    アレルギー   59 ( 9 )   1430 - 1430   2010

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.59.1430_2

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  • P3-2 マウスの気管支喘息経口免疫寛容モデルにおけるTh17の関連についての検討(P3 動物モデル,ポスター,第60回日本アレルギー学会秋季学術大会)

    河上 英則, 小屋 俊之, 木村 陽介, 星野 芳史, 古川 俊貴, 長谷川 隆志, 鈴木 栄一, 成田 一衛

    アレルギー   59 ( 9 )   1429 - 1429   2010

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.59.1429_2

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  • O22-4 ONO-1301(PGI2アゴニスト+TX合成酵素阻害)のマウス慢性喘息モデルにおける気道過敏性の抑制効果(O22 喘息動物モデル2,口演,第60回日本アレルギー学会秋季学術大会)

    小屋 俊之, 河上 英則, 木村 陽介, 星野 芳史, 坂上 拓郎, 坂元 宏隆, 長谷川 隆志, 酒井 芳紀, 松本 邦夫, 中山 瑞穂, 鈴木 栄一, 成田 一衛

    アレルギー   59 ( 9 )   1394 - 1394   2010

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.59.1394_1

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  • EVS9-1 アスリート喘息(EVS9 喘息を取り巻く最近の話題,イブニングシンポジウム,第60回日本アレルギー学会秋季学術大会)

    小屋 俊之, 河上 英則, 木村 陽介, 星野 芳史, 坂上 拓郎, 古川 俊貴, 長谷川 隆志, 鈴木 栄一, 荒川 正昭, 成田 一衛

    アレルギー   59 ( 9 )   1324 - 1324   2010

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.59.1324_2

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  • アレルゲン特異的舌下免疫療法における局所IgAの多面的役割について

    2020.9 - 2022.3

    System name：GSKジャパン研究助成2020

    Awarding organization：グラクソ・スミスクライン

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  • 医師に聞く『禁煙外来』(新型たばこ・新型コロナを含め) TV or radio program

    NST新潟総合テレビ  NST Newsタッチ  2020.9

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    Author：Myself 

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