2025/07/04 更新

写真a

サトウ トキハル
佐藤 時春
SATO Tokiharu
所属
脳研究所 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2008年12月   金沢大学 )

研究キーワード

  • 神経変性

  • 神経再生

  • 神経科学

研究分野

  • ライフサイエンス / 神経形態学

経歴(researchmap)

  • 新潟大学   脳研究所   助教

    2021年12月 - 現在

      詳細を見る

  • 新潟大学   脳研究所   特任助教

    2019年2月 - 2021年11月

      詳細を見る

  • テキサス大学ヒューストン校   医学部   博士研究員

    2015年10月 - 2019年1月

      詳細を見る

  • 金沢大学   がん進展制御研究所   助教

    2012年4月 - 2015年9月

      詳細を見る

  • 金沢大学   がん研究所   助教

    2009年1月 - 2012年3月

      詳細を見る

経歴

  • 新潟大学   脳研究所   助教

    2021年12月 - 現在

  • 新潟大学   脳研究所 生命科学リソース研究センター   特任助教

    2019年2月 - 現在

学歴

  • 金沢大学   医学系研究科

    - 2008年12月

      詳細を見る

    国名: 日本国

    researchmap

  • 金沢大学   Graduate School, Division of Medical Sciences

    - 2008年

      詳細を見る

所属学協会

 

論文

  • TDP-43 mutants with different aggregation properties exhibit distinct toxicity, axonal transport, and secretion for disease progression in a mouse ALS/FTLD model 査読

    Hideki Mori, Tokiharu Sato, Shintaro Tsuboguchi, Masahiko Takahashi, Yuka Nakamura, Kana Hoshina, Taisuke Kato, Masahiro Fujii, Osamu Onodera, Masaki Ueno

    Neurobiology of Disease   212   106988 - 106988   2025年8月

     詳細を見る

    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.nbd.2025.106988

    researchmap

  • Scg2 drives reorganization of the corticospinal circuit with spinal premotor interneurons to recover motor function after stroke

    Tokiharu Sato, Yuka Nakamura, Kana Hoshina, Ken-ichi Inoue, Masahiko Takada, Masato Yano, Hitoshi Matsuzawa, Masaki Ueno

    bioRxiv   2025年1月

     詳細を見る

    <jats:title>Abstract</jats:title><jats:p>Brain injuries such as stroke damage neural circuitry and lead to functional deficits. Spared motor pathways are often reorganized and contribute to functional recovery; however, the connectivity and molecular mechanisms that drive the reorganization are largely unknown. Here, we demonstrate structural and functional connectivity reformed by spared corticospinal axons after stroke and determine a key secretory protein that drives the reorganization. We first found that corticospinal axons innervate specific areas of the denervated cervical cord after stroke. Anatomical and photometric analyses reveal that the axons reconnect to premotor V2a interneurons. Kinematic analyses of forelimb movements and chemogenetic silencing reveal their contribution to motor recovery. Translated mRNA expression analyses of V2a interneurons and astrocytes in the denervated cervical cord reveal diverse transcripts upregulated in the rewiring process. In particular, a secretory protein Scg2 is upregulated by injury-induced purinergic ATP signals and rehabilitative training-induced neural activity and possesses an ability to promote axon growth via cAMP and S6 signaling. Scg2 overexpression in the denervated cervical cord enhances axon rewiring, while the Scg2 knockdown attenuates it. The present data reveal the neural substrate and molecular mechanism essential to induce reorganization and recovery of the motor system, providing fundamental therapeutic targets for CNS injuries.</jats:p>

    DOI: 10.1101/2025.01.21.634186

    researchmap

  • CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice 査読

    Shoji Saito, Yuka Nakamura, Satoshi Miyashita, Tokiharu Sato, Kana Hoshina, Masayasu Okada, Hitoshi Hasegawa, Makoto Oishi, Yukihiko Fujii, Jakob Körbelin, Yoshiaki Kubota, Kazuki Tainaka, Manabu Natsumeda, Masaki Ueno

    JCI Insight   9 ( 22 )   2024年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Society for Clinical Investigation  

    DOI: 10.1172/jci.insight.179729

    researchmap

  • TDP-43は運動回路の変性を誘導するために異なって伝播する(TDP-43 differentially propagates to induce degeneration in the motor circuit)

    坪口 晋太朗, 中村 由香, 石原 智彦, 加藤 泰介, 佐藤 時春, 小山 哲秀, 森 秀樹, 小池 佑佳, 小野寺 理, 上野 将紀

    Dementia Japan   37 ( 4 )   680 - 680   2023年10月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本認知症学会  

    researchmap

  • TDP-43 differentially propagates to induce antero- and retrograde degeneration in the corticospinal circuits in mouse focal ALS models. 査読 国際誌

    Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno

    Acta neuropathologica   2023年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by TDP-43 inclusions in the cortical and spinal motor neurons. It remains unknown whether and how pathogenic TDP-43 spreads across neural connections to progress degenerative processes in the cortico-spinal motor circuitry. Here we established novel mouse ALS models that initially induced mutant TDP-43 inclusions in specific neuronal or cell types in the motor circuits, and investigated whether TDP-43 and relevant pathological processes spread across neuronal or cellular connections. We first developed ALS models that primarily induced TDP-43 inclusions in the corticospinal neurons, spinal motor neurons, or forelimb skeletal muscle, by using adeno-associated virus (AAV) expressing mutant TDP-43. We found that TDP-43 induced in the corticospinal neurons was transported along the axons anterogradely and transferred to the oligodendrocytes along the corticospinal tract (CST), coinciding with mild axon degeneration. In contrast, TDP-43 introduced in the spinal motor neurons did not spread retrogradely to the cortical or spinal neurons; however, it induced an extreme loss of spinal motor neurons and subsequent degeneration of neighboring spinal neurons, suggesting a degenerative propagation in a retrograde manner in the spinal cord. The intraspinal degeneration further led to severe muscle atrophy. Finally, TDP-43 induced in the skeletal muscle did not propagate pathological events to spinal neurons retrogradely. Our data revealed that mutant TDP-43 spread across neuro-glial connections anterogradely in the corticospinal pathway, whereas it exhibited different retrograde degenerative properties in the spinal circuits. This suggests that pathogenic TDP-43 may induce distinct antero- and retrograde mechanisms of degeneration in the motor system in ALS.

    DOI: 10.1007/s00401-023-02615-8

    PubMed

    researchmap

  • Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord. 査読 国際誌

    Yuka Nakamura, Miyuki Kurabe, Mami Matsumoto, Tokiharu Sato, Satoshi Miytashita, Kana Hoshina, Yoshinori Kamiya, Kazuki Tainaka, Hitoshi Matsuzawa, Nobuhiko Ohno, Masaki Ueno

    eLife   12   e83108   2023年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Cerebrospinal fluid-contacting neurons (CSF-cNs) are enigmatic mechano- or chemosensory cells lying along the central canal of the spinal cord. Recent studies in zebrafish larvae and lampreys have shown that CSF-cNs control postures and movements via spinal connections. However, the structures, connectivity, and functions in mammals remain largely unknown. Here we developed a method to genetically target mouse CSF-cNs that highlighted structural connections and functions. We first found that intracerebroventricular injection of adeno-associated virus with a neuron-specific promoter and Pkd2l1-Cre mice specifically labeled CSF-cNs. Single-cell labeling of 71 CSF-cNs revealed rostral axon extensions of over 1800 μm in unmyelinated bundles in the ventral funiculus and terminated on CSF-cNs to form a recurrent circuitry, which was further determined by serial electron microscopy and electrophysiology. CSF-cNs were also found to connect with axial motor neurons and premotor interneurons around the central canal and within the axon bundles. Chemogenetic CSF-cNs inactivation reduced speed and step frequency during treadmill locomotion. Our data revealed the basic structures and connections of mouse CSF-cNs to control spinal motor circuits for proper locomotion. The versatile methods developed in this study will contribute to further understanding of CSF-cN functions in mammals.

    DOI: 10.7554/eLife.83108

    PubMed

    researchmap

  • Lesion Area in the Cerebral Cortex Determines the Patterns of Axon Rewiring of Motor and Sensory Corticospinal Tracts After Stroke 査読

    Tokiharu Sato, Yuka Nakamura, Akinori Takeda, Masaki Ueno

    Frontiers in Neuroscience   15   2021年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Frontiers Media SA  

    The corticospinal tract (CST) is an essential neural pathway for reorganization that recovers motor functions after brain injuries such as stroke. CST comprises multiple pathways derived from different sensorimotor areas of the cerebral cortex; however, the patterns of reorganization in such complex pathways postinjury are largely unknown. Here we comprehensively examined the rewiring patterns of the CST pathways of multiple cerebral origins in a mouse stroke model that varied in size and location in the sensorimotor cortex. We found that spared contralesional motor and sensory CST axons crossed the midline and sprouted into the denervated side of the cervical spinal cord after stroke in a large cortical area. In contrast, the contralesional CST fibers did not sprout in a small stroke, whereas the ipsilesional axons from the spared motor area grew on the denervated side. We further showed that motor and sensory CST axons did not innervate the projecting areas mutually when either one was injured. The present results reveal the basic principles that generate the patterns of CST rewiring, which depend on stroke location and CST subtype. Our data indicate the importance of targeting different neural substrates to restore function among the types of injury.

    DOI: 10.3389/fnins.2021.737034

    PubMed

    researchmap

  • Direct Comparison of Odor Responses of Homologous Glomeruli in the Medial and Lateral Maps of the Mouse Olfactory Bulb 査読

    Tokiharu Sato, Ryota Homma, Shin Nagayama

    eneuro   7 ( 2 )   ENEURO.0449 - 19.2020   2020年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Society for Neuroscience  

    Abstract

    Olfactory sensory neurons (OSNs) expressing same-type odorant receptors typically project to a pair of glomeruli in the medial and lateral sides of the olfactory bulbs (OBs) in rodents. This multiple glomerular representation of homologous inputs is considered to have more important functional roles for odor information processing than the redundant backup system. However, a consensus idea is lacking and this hinders interpretation of the phenomenon. In addition, the shared and unique odorant response properties of the homologous glomeruli remain unclear because the majority of medial glomeruli are hidden in the septal OB, and thus it is difficult to directly compare them. OSNs, which express trace amine-associated odorant receptors (TAARs), were recently identified that project to a pair of glomeruli uniquely located in the dorsal OB. In this study, we measured the odorant-induced calcium responses of homologous pairs of TAAR glomeruli simultaneously in anesthetized mice and directly compared their response patterns. We found that they exhibited similar temporal response patterns and could not find differences in onset latency, rise time, decay time, or response amplitude. However, the medial glomeruli had significantly larger respiration-locked calcium fluctuations than the lateral glomeruli. This trend was observed with/without odorant stimulation in postsynaptic neurons of GABAergic, dopaminergic, and mitral/tufted cells, but not in presynaptic olfactory sensory axon terminals. This indicates that, at least in these TAAR glomeruli, the medial rather than the lateral OB map enhances the respiration-locked rhythm and transfers this information to higher brain centers.

    DOI: 10.1523/eneuro.0449-19.2020

    researchmap

  • Narrowly Confined and Glomerulus-Specific Onset Latencies of Odor-Evoked Calcium Transients in the Juxtaglomerular Cells of the Mouse Main Olfactory Bulb 査読

    Ryota Homma, Xiaohua Lv, Tokiharu Sato, Fumiaki Imamura, Shaoqun Zeng, Shin Nagayama

    eneuro   6 ( 1 )   ENEURO.0387 - 18.2019   2019年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Society for Neuroscience  

    Abstract

    Odor information is transmitted from olfactory sensory neurons to principal neurons at the glomeruli of the olfactory bulb. The intraglomerular neuronal circuit also includes hundreds of interneurons referred to as juxtaglomerular (JG) cells. Stimulus selectivity is well correlated among many JG cells that are associated with the same glomerulus, consistent with their highly homogeneous sensory inputs. However, much less is known about the temporal aspects of their activity, including the temporal coordination of their odor-evoked responses. As many JG cells within a glomerular module respond to the same stimulus, the extent to which their activity is temporally aligned will affect the temporal profile of their population inhibitory inputs. Using random-access high-speed two-photon microscopy, we recorded the odor-evoked calcium transients of mouse JG cells and compared the onset latency and rise time among neurons putatively associated with the same and different glomeruli. Whereas the overall onset latencies of odor-evoked transients were distributed across a ∼150 ms time window, those from cells putatively associated with the same glomerulus were confined to a much narrower window of several tens of milliseconds. This result suggests that onset latency primarily depends on the associated glomerulus. We also observed glomerular specificity in the rise time. The glomerulus-specific temporal pattern of odor-evoked activity implies that the temporal patterns of inputs from the intraglomerular circuit are unique to individual glomerulus–odor pairs, which may contribute to efficient shaping of the temporal pattern of activity in the principal neurons.

    DOI: 10.1523/eneuro.0387-18.2019

    researchmap

  • The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication. 査読 国際誌

    Takayoshi Shirasaki, Masao Honda, Taro Yamashita, Kouki Nio, Tetsuro Shimakami, Ryougo Shimizu, Saki Nakasyo, Kazuhisa Murai, Natsumi Shirasaki, Hikari Okada, Yoshio Sakai, Tokiharu Sato, Tetsuro Suzuki, Katsuji Yoshioka, Shuichi Kaneko

    Scientific reports   8 ( 1 )   13143 - 13143   2018年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression in various tissues. OPN induces stemness by interacting with CD44, but the functional relevance of OPN-mediated interferon (IFN) signaling and hepatitis C virus (HCV) replication in stem cell populations remains unclear. In this study, we investigated the effect of OPN on HCV replication and IFN signaling in cancer stem cells (CSCs) positive for epithelial cell adhesion molecule (EpCAM) and CD44. We show that the EpCAM+/CD44+ CSCs show marked HCV replication when compared to EpCAM-/CD44- cells. In addition, OPN significantly enhances this HCV replication in EpCAM+/CD44+ CSCs and markedly suppresses IFN-stimulated gene expression. The GSK-3β inhibitor BIO increases the EpCAM+/CD44+ CSC population and OPN expression and impairs IFN signaling via STAT1 degradation. Taken together, our data suggest that OPN enhances HCV replication in the EpCAM+/CD44+ CSCs, while it also negatively regulates the IFN signaling pathway via inhibition of STAT1 phosphorylation and degradation. Therefore, OPN may represent a novel therapeutic target for treating HCV-related hepatocellular carcinoma.

    DOI: 10.1038/s41598-018-31421-6

    PubMed

    researchmap

  • Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice 査読

    Tokiharu Sato, Momoe Ishikawa, Toru Yoshihara, Ryota Nakazato, Haruhiro Higashida, Masahide Asano, Katsuji Yoshioka

    FEBS LETTERS   589 ( 19 )   2805 - 2811   2015年9月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.febslet.2015.08.024

    Web of Science

    PubMed

    researchmap

  • JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration 査読

    T. Sato, M. Ishikawa, M. Mochizuki, M. Ohta, M. Ohkura, J. Nakai, N. Takamatsu, K. Yoshioka

    CELL DEATH AND DIFFERENTIATION   22 ( 8 )   1260 - 1274   2015年8月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/cdd.2014.207

    Web of Science

    PubMed

    researchmap

  • JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis 査読

    Baljinnyam Tuvshintugs, Tokiharu Sato, Radnaa Enkhtuya, Katsumi Yamashita, Katsuji Yoshioka

    GENES TO CELLS   19 ( 9 )   692 - 703   2014年9月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/gtc.12170

    Web of Science

    PubMed

    researchmap

  • The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice 査読

    Radnaa Enkhtuya, Tokiharu Sato, Mitsuo Wakasugi, Baljinnyam Tuvshintugs, Hirofumi Miyata, Takeshi Sakurai, Tsukasa Matsunaga, Katsuji Yoshioka

    GENES TO CELLS   19 ( 4 )   350 - 358   2014年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/gtc.12135

    Web of Science

    PubMed

    researchmap

  • Human microRNA-1245 down-regulates the NKG2D receptor in natural killer cells and impairs NKG2D-mediated functions 査読

    J. Luis Espinoza, Akiyoshi Takami, Katsuji Yoshioka, Katsuya Nakata, Tokiharu Sato, Yoshihito Kasahara, Shinji Nakao

    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL   97 ( 9 )   1295 - 1303   2012年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3324/haematol.2011.058529

    Web of Science

    PubMed

    researchmap

  • Role of plasma membrane localization of the scaffold protein JSAP1 during differentiation of cerebellar granule cell precursors 査読

    Tokiharu Sato, Anir Enkhbat, Katsuji Yoshioka

    GENES TO CELLS   16 ( 1 )   58 - 68   2011年1月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1365-2443.2010.01465.x

    Web of Science

    PubMed

    researchmap

  • Ablation of the scaffold protein JLP causes reduced fertility in male mice. 査読 国際誌

    Iwanaga A, Wang G, Gantulga D, Sato T, Baljinnyam T, Shimizu K, Takumi K, Hayasi M, Akashi T, Fuse H, Sugihara K, Asano M, Yoshioka K

    Transgenic Research   17 ( 6 )   1045 - 1058   2008年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11248-008-9191-6

    PubMed

    researchmap

  • Ablation of the scaffold protein JLP causes reduced fertility in male mice 査読

    Asuka Iwanaga, Guangmin Wang, Davaakhuu Gantulga, Tokiharu Sato, Tuvshintugs Baljinnyam, Keiko Shimizu, Ken Takumi, Motoharu Hayashi, Takuya Akashi, Hideki Fuse, Kazushi Sugihara, Masahide Asano, Katsuji Yoshioka

    Transgenic Research   17 ( 6 )   1045 - 1058   2008年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11248-008-9191-6

    Scopus

    PubMed

    researchmap

  • The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling 査読

    Tokiharu Sato, Takashi Torashima, Kazushi Sugihara, Hirokazu Hirai, Masahide Asano, Katsuji Yoshioka

    MOLECULAR AND CELLULAR NEUROSCIENCE   39 ( 4 )   569 - 578   2008年11月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.mcn.2008.08.003

    Web of Science

    PubMed

    researchmap

  • Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death 査読

    Asuka Iwanaga, Tokiharu Sato, Kazushi Sugihara, Atsushi Hirao, Nobuyuki Takakura, Hiroshi Okamoto, Masahide Asano, Katsuji Yoshioka

    NEUROSCIENCE LETTERS   429 ( 1 )   43 - 48   2007年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neulet.2007.09.057

    Web of Science

    PubMed

    researchmap

  • Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. 査読 国際誌

    Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M

    Journal of neurochemistry   97 ( 5 )   1431 - 1446   2006年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:5  

    DOI: 10.1111/j.1471-4159.2006.03835.x

    PubMed

    researchmap

  • Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain 査読

    Eriko Miura, Masahiro Fukaya, Tokiharu Sato, Kazushi Sugihara, Masahide Asano, Katsuji Yoshioka, Masahiko Watanabe

    Journal of Neurochemistry   97 ( 5 )   1431 - 1446   2006年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1471-4159.2006.03835.x

    Scopus

    PubMed

    researchmap

  • Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in mouse brain 査読

    Miura Eriko, Fukaya Masahiro, Sato Tokiharu, Sugihara Kazushi, Asano Masahide, Yoshioka Katsuji, Watanabe Masahiko

    NEUROSCIENCE RESEARCH   55   S179   2006年

  • Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1 査読

    T Sato, K Hidaka, A Iwanaga, M Ito, M Asano, Y Nakabeppu, T Morisaki, K Yoshioka

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   338 ( 2 )   1152 - 1157   2005年12月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbrc.2005.10.052

    Web of Science

    PubMed

    researchmap

  • JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration 査読

    T Takino, M Nakada, H Miyamori, Y Watanabe, T Sato, D Gantulga, K Yoshioka, KM Yamada, H Sato

    JOURNAL OF BIOLOGICAL CHEMISTRY   280 ( 45 )   37772 - 37781   2005年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1074/jbc.M505241200

    Web of Science

    PubMed

    researchmap

  • Structure, regulation, and function of micro1 in the sea urchin Hemicentrotus pulcherrimus 査読

    Y Nishimura, T Sato, Y Morita, A Yamazaki, K Akasaka, M Yamaguchi

    DEVELOPMENT GENES AND EVOLUTION   214 ( 11 )   525 - 536   2004年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00427-004-0442-0

    Web of Science

    PubMed

    researchmap

▶ 全件表示

MISC

  • 脳梗塞後における皮質脊髄路の再編様式と分子機序 招待

    佐藤時春, 上野将紀

    Medical Science Digest   50 ( 6 )   48 - 50   2024年5月

     詳細を見る

    担当区分:筆頭著者   記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

    researchmap

  • TDP-43 differentially propagates to induce degeneration in the motor circuit

    坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理, 上野将紀

    Dementia Japan   37 ( 4 )   2023年

     詳細を見る

  • TDP-43変異型により異なる病態進展特性の解析

    森秀樹, 坪口晋太朗, 佐藤時春, 中村由香, 加藤泰介, 須貝章弘, 小野寺理, 上野将紀

    Dementia Japan   37 ( 4 )   2023年

     詳細を見る

  • 脳・脊髄障害後の神経回路再編の可視化 招待

    佐藤時春, 上野将紀

    CLINICAL NEUROSCIENCE   40 ( 6 )   746 - 749   2022年6月

     詳細を見る

    担当区分:筆頭著者   記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

    researchmap

  • Intracortical and corticospinal spreading of TDP-43 in mouse FTLD/ALS models(和訳中)

    坪口 晋太朗, 中村 由香, 石原 智彦, 加藤 泰介, 小山 哲秀, 佐藤 時春, 吉田 富, 上野 将紀, 小野寺 理

    Dementia Japan   34 ( 4 )   524 - 524   2020年10月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本認知症学会  

    researchmap

  • FTLD/ALSモデルマウスにおけるTDP-43の皮質内と皮質脊髄内での増殖(Intracortical and corticospinal spreading of TDP-43 in mouse FTLD/ALS models)

    坪口 晋太朗, 中村 由香, 石原 智彦, 加藤 泰介, 小山 哲秀, 佐藤 時春, 吉田 富, 上野 将紀, 小野寺 理

    Dementia Japan   34 ( 4 )   524 - 524   2020年10月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本認知症学会  

    researchmap

  • マウスモデルにおける直接皮質脊髄路接続を介するTDP-43の拡散

    TSUBOGUCHI Shintaro, NAKAMURA Yuka, ISHIHARA Tomohiko, KATO Taisuke, KOYAMA Akihide, SATO Tokiharu, YOSHIDA Yutaka, UENO Masaki, ONODERA Osamu

    日本神経学会学術大会プログラム・抄録集   61st   2020年

     詳細を見る

  • 「匂い地図」として表現される匂い情報の処理基盤とその神経回路機構 招待

    佐藤時春

    AROMA RESEARCH   19 ( 4 )   2018年

     詳細を見る

  • A cell-autonomous role for JSAP1 and JLP in mouse cerebellar Purkinje cell survival

    Momoe Ishikawa, Tokiharu Sato, Hiroshi Kiyonari, Katsuji Yoshioka

    The science reports of the Kanazawa University = 金沢大学理科報告   59   51 - 60   2015年1月

     詳細を見る

    記述言語:英語   出版者・発行元:Institute of Science and Engineering, Kanazawa University = 金沢大学  

    We previously reported that the structurally related JNK scaffolding proteins JSAP1 and JLP play functionally redundant and key roles in maintaining mouse cere-bellar Purkinje cell (PC) survival, which may be related to their regulation of axonal transport. The JSAP1 and JLP proteins are also widely expressed in other cell types throughout the brain. Notably, in the cerebellum, JSAP1 is abundantly expressed in the pinceau, a cluster of basket cell (BC) axons and termini that surround the PC axon initial segment. Thus, it is possible that BC-expressed JSAP1 plays a role in PC survival. To investigate this possibility, we generated and analyzed mice containing a PC/BC-specific double knockout (DKO) of Jsap1 and Jlp (Jsap1:Jlp cDKO mice). These mice exhibited PC axonal dystrophy, followed by progressive PC loss, consistent with the phenotypes previously reported for PC-specific Jsap1 and Jlp DKO mice. Furthermore, we found that the phenotypes of Jsap1:Jlp cDKO PCs were rescued by PC-specific transgenic expression of JSAP1. Taken together, these results indicate that BC-expressed JSAP1 plays little or no role in PC survival, and that PC-expressed JSAP1 and JLP play cell-autonomous roles in preventing PC degeneration.

    CiNii Article

    CiNii Books

    researchmap

  • JSAP1とJLPによる軸索輸送の制御とその破綻がもたらす神経変性の分子機構 招待

    佐藤時春, 石川桃絵, 善岡克次

    BioMedサーカス   2015年

     詳細を見る

    担当区分:筆頭著者  

    researchmap

  • Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP

    Sato T., Hidaka K., Iwanaga A., Ito M., Asano M., Nakabeppu Y., Morisaki T., Yoshioka Katsuji

    Cancer Research Institute report   2003   66 - 66   2006年3月

     詳細を見る

    記述言語:英語   出版者・発行元:金沢大学がん研究所  

    CiNii Article

    researchmap

▶ 全件表示

産業財産権

  • 情動障害の治療剤のスクリーニング方法

    善岡 克次, 吉原 亨, 佐藤 時春, 浅野 雅秀

     詳細を見る

    出願番号:特願2010-208662  出願日:2010年9月

    公開番号:特開2011-089982 

    researchmap

受賞

  • The 25th Annual Neuroscience Poster Session, 1st place prize

    2018年12月  

    佐藤 時春

     詳細を見る

共同研究・競争的資金等の研究

  • 脳梗塞からの機能回復過程における時間的・空間的な病態の遷移プロセスの解明

    研究課題/領域番号:21K07290

    2021年4月 - 2025年3月

    制度名:科学研究費助成事業

    研究種目:基盤研究(C)

    提供機関:日本学術振興会

    佐藤 時春

      詳細を見る

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    脳梗塞は神経回路機能の破綻を引き起こす。限定的ではあるものの、再編により代償性の回路が形成され、一定の機能回復を示す。しかし、脳梗塞は引き起こされる部位やその大きさは様々であるため、再編様式も複雑であることが予想される。そこで、本年度は、脳梗塞の起こる位置や大きさにより、皮質脊髄路がどのような再編パターンを示すのかを調べた。そのために、まず、マウスにおいて、皮質脊髄路の様々なタイプが位置するrostral forelimb area (RFA)、caudal forelimb area (CFA)、primary somatosensory cortex (S1)の大脳皮質領域で脳梗塞の位置や大きさを調節できる実験モデルを確立し、順行性トレーサーで皮質脊髄路をタイプ別に標識することで、軸索投射のパターンを詳細に解析、評価した。その結果、1. 広範囲な梗塞の場合、残存した対側の皮質脊髄路は再編を起こすこと、2. 障害領域が小さい場合、周囲の残存した同側の皮質脊髄路が再編に寄与すること、3. 運動野と感覚野のような機能的に異なった皮質脊髄路はお互いに再編による代償的な回路を形成しないという再編機序を見出した。

    researchmap

  • 脳障害後の神経回路再編における時空間的・神経活動依存的な遺伝子発現の包括的解析

    研究課題/領域番号:19K23773

    2019年8月 - 2021年3月

    制度名:科学研究費助成事業

    研究種目:研究活動スタート支援

    提供機関:日本学術振興会

    佐藤 時春

      詳細を見る

    配分額:2860000円 ( 直接経費:2200000円 、 間接経費:660000円 )

    脳障害は神経回路機能の破綻を引き起こす。その後、再編により代償性の回路が形成され、一定の機能回復を示す。本研究では回路再編にはたらく遺伝子の時空間的発現パターンを解明することを課題とした。梗塞による大脳皮質障害後、残存した皮質脊髄路の経時的な再編パターン、および脊髄内における遺伝子の時空間的発現パターン、さらには、リハビリテーションにより惹起される神経活動依存的な遺伝子発現を解明した。

    researchmap

 

担当経験のある授業科目(researchmap)

  • 動物生理学実験

    機関名:金沢大学

     詳細を見る

  • 分子生物学

    機関名:金沢大学

     詳細を見る