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TRIM67 Protein Negatively Regulates Ras Activity through Degradation of 80K-H and Induces Neuritogenesis 査読

Hiroaki Yaguchi, Fumihiko Okumura, Hidehisa Takahashi, Takahiro Kano, Hiroyuki Kameda, Motokazu Uchigashima, Shinya Tanaka, Masahiko Watanabe, Hidenao Sasaki, Shigetsugu Hatakeyama

JOURNAL OF BIOLOGICAL CHEMISTRY 287 ( 15 ) 12050 - 12059 2012年4月

Striatal direct pathway modulates response time in execution of visual discrimination 査読

Ryoji Fukabori, Kana Okada, Kayo Nishizawa, Nobuyuki Kai, Kenta Kobayashi, Motokazu Uchigashima, Masahiko Watanabe, Yuji Tsutsui, Kazuto Kobayashi

EUROPEAN JOURNAL OF NEUROSCIENCE 35 ( 5 ) 784 - 797 2012年3月

Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease 査読

Valentina Chiodi, Motokazu Uchigashima, Sarah Beggiato, Antonella Ferrante, Monica Armida, Alberto Martire, Rosa Luisa Potenza, Luca Ferraro, Sergio Tanganelli, Masahiko Watanabe, Maria Rosaria Domenici, Patrizia Popoli

NEUROBIOLOGY OF DISEASE 45 ( 3 ) 983 - 991 2012年3月

Selective Neural Pathway Targeting Reveals Key Roles of Thalamostriatal Projection in the Control of Visual Discrimination 査読

Shigeki Kato, Masahito Kuramochi, Kenta Kobayashi, Ryoji Fukabori, Kana Okada, Motokazu Uchigashima, Masahiko Watanabe, Yuji Tsutsui, Kazuto Kobayashi

JOURNAL OF NEUROSCIENCE 31 ( 47 ) 17169 - 17179 2011年11月

Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. 査読

Uchigashima M, Yamazaki M, Yamasaki M, Tanimura A, Sakimura K, Kano M, Watanabe M

The Journal of neuroscience : the official journal of the Society for Neuroscience 31 ( 21 ) 7700 - 7714 2011年5月

担当区分：筆頭著者記述言語：英語出版者・発行元：21

2-Arachidonoylglycerol (2-AG) is the endocannabinoid that mediates retrograde suppression of neurotransmission in the brain. In the present study, we investigated the 2-AG signaling system at mossy cell (MC)-granule cell (GC) synapses in the mouse dentate gyrus, an excitatory recurrent circuit where endocannabinoids are thought to suppress epileptogenesis. First, we showed by electrophysiology that 2-AG produced by diacylglycerol lipase α(DGLα) mediated both depolarization-induced suppression of excitation and its enhancement by group I metabotropic glutamate receptor activation at MC-GC synapses, as they were abolished in DGLα-knock-out mice. Immunohistochemistry revealed that DGLα was enriched in the neck portion of GC spines forming synapses with MC terminals, whereas cannabinoid CB1 receptors accumulated in the terminal portion of MC axons. On the other hand, the major 2-AG-degrading enzyme, monoacylglycerol lipase (MGL), was absent at MC-GC synapses but was expressed in astrocytes and some inhibitory terminals. Serial electron microscopy clarified that a given GC spine was innervated by a single MC terminal and also contacted nonsynaptically by other MC terminals making synapses with other GC spines in the neighborhood. MGL-expressing elements, however, poorly covered GC spines, amounting to 17% of the total surface of GC spines by astrocytes and 4% by inhibitory terminals. Our findings provide a basis for 2-AG-mediated retrograde suppression of MC-GC synaptic transmission and also suggest that 2-AG released from activated GC spines is readily accessible to nearby MC-GC synapses by escaping from enzymatic degradation. This molecular-anatomical configuration will contribute to adjust network activity in the dentate gyrus after enhanced excitation.

DOI： 10.1523/JNEUROSCI.5665-10.2011

PubMed

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Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus 査読

Takayuki Yoshida, Motokazu Uchigashima, Miwako Yamasaki, Istvan Katona, Maya Yamazaki, Kenji Sakimura, Masanobu Kano, Mitsuhiro Yoshioka, Masahiko Watanabe

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108 ( 7 ) 3059 - 3064 2011年2月

Rho/Rho-kinase signaling pathway controls axon patterning of a specified subset of cranial motor neurons 査読

Kenta Kobayashi, Tomoyuki Masuda, Masanori Takahashi, Jun-ichi Miyazaki, Masahiro Nakagawa, Motokazu Uchigashima, Masahiko Watanabe, Hiroyuki Yaginuma, Noriko Osumi, Kozo Kaibuchi, Kazuto Kobayashi

EUROPEAN JOURNAL OF NEUROSCIENCE 33 ( 4 ) 612 - 621 2011年2月

Cellular expression and subcellular localization of secretogranin II in the mouse hippocampus and cerebellum 査読

Taisuke Miyazaki, Miwako Yamasaki, Motokazu Uchigashima, Ayano Matsushima, Masahiko Watanabe

EUROPEAN JOURNAL OF NEUROSCIENCE 33 ( 1 ) 82 - 94 2011年1月

Invaginating inhibitory synapse with particularly rich endocannabinoid signaling machinery in the basal nucleus of the amygdala 査読

Yoshida Takayuki, Uchigashima Motokazu, Yamasaki Miwako, Katona Istvan, Yamazaki Maya, Sakimura Kenji, Kano Masanobu, Yoshioka Mitsuhiro, Watanabe Masahiko

NEUROSCIENCE RESEARCH 71 E93 - E94 2011年

Neurochemical characterization of neurons in the bed nucleus of the stria terminalis projecting to the ventral tegmental area 査読

Kudo Takehiro, Uchigashima Motokazu, Miyazaki Taisuke, Yamasaki Miwako, Minami Masabumi, Watanabe Masahiko

NEUROSCIENCE RESEARCH 71 E322 2011年

Cytochemical and cytological properties of perineuronal oligodendrocytes in the mouse cortex 査読

Chihiro Takasaki, Miwako Yamasaki, Motokazu Uchigashima, Kohtarou Konno, Yuchio Yanagawa, Masahiko Watanabe

European Journal of Neuroscience 32 ( 8 ) 1326 - 1336 2010年10月

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase alpha Mediates Retrograde Suppression of Synaptic Transmission 査読

Asami Tanimura, Maya Yamazaki, Yuki Hashimotodani, Motokazu Uchigashima, Shinya Kawata, Manabu Abe, Yoshihiro Kita, Kouichi Hashimoto, Takao Shimizu, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano

NEURON 65 ( 3 ) 320 - 327 2010年2月

Endocannabinoid-Mediated Control of Synaptic Transmission 査読

Masanobu Kano, Takako Ohno-Shosaku, Yuki Hashimotodani, Motokazu Uchigashima, Masahiko Watanabe

PHYSIOLOGICAL REVIEWS 89 ( 1 ) 309 - 380 2009年1月

Key Modulatory Role of Presynaptic Adenosine A(2A) Receptors in Cortical Neurotransmission to the Striatal Direct Pathway 査読

Cesar Quiroz, Rafael Lujan, Motokazu Uchigashima, Ana Patricia Simoes, Talia N. Lerner, Janusz Borycz, Anil Kachroo, Paula M. Canas, Marco Orru, Michael A. Schwarzschild, Diane L. Rosin, Anatol C. Kreitzer, Rodrigo A. Cunha, Masahiko Watanabe, Sergi Ferre

THESCIENTIFICWORLDJOURNAL 9 1321 - 1344 2009年

Predominant expression of phospholipase C beta 1 in telencephalic principal neurons and cerebellar interneurons, and its close association with related signaling molecules in somatodendritic neuronal elements 査読

Masahiro Fukaya, Motokazu Uchigashima, Sachi Nomura, Yuta Hasegawa, Hisaya Kikuchi, Masahiko Watanabe

EUROPEAN JOURNAL OF NEUROSCIENCE 28 ( 9 ) 1744 - 1759 2008年11月

Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus 査読

Motokazu Uchigashima, Masahiro Fukaya, Masahiko Watanabe, Haruyuki Kamiya

JOURNAL OF NEUROSCIENCE 27 ( 30 ) 8088 - 8100 2007年7月

Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum 査読

Motokazu Uchigashima, Madoka Narushima, Masahiro Fukaya, Istvan Katona, Masanobu Kano, Masahiko Watanabe

JOURNAL OF NEUROSCIENCE 27 ( 14 ) 3663 - 3676 2007年4月

Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum 査読

Madoka Narushima, Motokazu Uchigashima, Masahiro Fukaya, Minoru Matsui, Toshiya Manabe, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kano

JOURNAL OF NEUROSCIENCE 27 ( 3 ) 496 - 506 2007年1月

Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling in the striatum 査読

Uchigashima Motokazu, Narushima Madoka, Fukaya Masahiro, Katona Istven, Kano Masanobu, Watanabe Masahiko

NEUROSCIENCE RESEARCH 58 S75 2007年

Depolarization-induced suppression of inhibition mediated by endocannabinoids at synapses from fast-spiking interneurons to medium spiny neurons in the striatum 査読

Madoka Narushima, Motokazu Uchigashima, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kano

EUROPEAN JOURNAL OF NEUROSCIENCE 24 ( 8 ) 2246 - 2252 2006年10月

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