2021/10/25 更新

写真a

ヤノ ヨシカ
矢野 佳芳
YANO Yoshika
所属
教育研究院 医歯学系 特任助教
医歯学総合研究科 特任助教
職名
特任助教
外部リンク

学位

  • 博士(医学) ( 2007年7月   慶應義塾大学 )

  • 修士(医科学) ( 2001年3月   筑波大学 )

研究キーワード

  • 神経変性疾患

  • 神経発生

  • HITS-CLIP

  • RNA結合タンパク質

  • 分子神経生物学

研究分野

  • ライフサイエンス / 神経科学一般

  • ライフサイエンス / 医化学

  • ライフサイエンス / 発生生物学

  • ライフサイエンス / 分子生物学

  • ライフサイエンス / 病態神経科学

経歴(researchmap)

  • 慶應義塾大学   医学部 生理学教室   訪問講師

    2021年5月 - 現在

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  • 新潟大学   大学院医歯学総合研究科   特任助教

    2019年4月 - 現在

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  • 新潟大学   産学官連携研究員

    2018年10月 - 2019年3月

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  • 新潟大学   日本学術振興会特別研究員(RPD)

    2015年10月 - 2018年9月

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  • 慶應義塾大学   医学部   非常勤助教

    2014年 - 2015年

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  • ロックフェラー大学   博士研究員

    2008年 - 2011年

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  • 岐阜大学   大学院医学系研究科   助教

    2004年 - 2007年

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  • 慶應義塾大学   日本学術振興会特別研究員(DC1)

    2002年 - 2004年

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経歴

  • 新潟大学   医歯学総合研究科   特任助教

    2019年4月 - 現在

所属学協会

 

論文

  • DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2 査読

    Masahiro Nogami, Kazumasa Miyamoto, Yoshika Hayakawa-Yano, Atsushi Nakanishi, Masato Yano, Hideyuki Okano

    Journal of Biological Chemistry   296   100409 - 100409   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.jbc.2021.100409

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  • An RNA Switch of a Large Exon of Ninein Is Regulated by the Neural Stem Cell Specific-RNA Binding Protein, Qki5. 査読

    Hayakawa-Yano Y, Yano M

    International journal of molecular sciences   20 ( 5 )   2019年2月

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    担当区分:筆頭著者  

    DOI: 10.3390/ijms20051010

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  • An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling 査読

    Yoshika Hayakawa-Yano, Satoshi Suyama, Masahiro Nogami, Masato Yugami, Ikuko Koya, Takako Furukawa, Li Zhou, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi, Atsushi Nakanishi, Hideyuki Okano, Masato Yano

    GENES & DEVELOPMENT   31 ( 18 )   1910 - 1925   2017年9月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT  

    Cell type-specific transcriptomes are enabled by the action of multiple regulators, which are frequently expressed within restricted tissue regions. In the present study, we identify one such regulator, Quaking 5 (Qki5), as an RNA-binding protein (RNABP) that is expressed in early embryonic neural stem cells and subsequently down-regulated during neurogenesis. mRNA sequencing analysis in neural stem cell culture indicates that Qki proteins play supporting roles in the neural stem cell transcriptome and various forms of mRNA processing that may result from regionally restricted expression and subcellular localization. Also, our in utero electroporation gain-of-function study suggests that the nuclear-type Qki isoform Qki5 supports the neural stem cell state. We next performed in vivo transcriptome-wide protein-RNA interaction mapping to search for direct targets of Qki5 and elucidate how Qki5 regulates neural stem cell function. Combined with our transcriptome analysis, this mapping analysis yielded a bona fide map of Qki5-RNA interaction at single-nucleotide resolution, the identification of 892 Qki5 direct target genes, and an accurate Qki5-dependent alternative splicing rule in the developing brain. Last, our target gene list provides the first compelling evidence that Qki5 is associated with specific biological events; namely, cell-cell adhesion. This prediction was confirmed by histological analysis of mice in which Qki proteins were genetically ablated, which revealed disruption of the apical surface of the lateral wall in the developing brain. These data collectively indicate that Qki5 regulates communication between neural stem cells by mediating numerous RNA processing events and suggest new links between splicing regulation and neural stem cell states.

    DOI: 10.1101/gad.300822.117

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  • RNA regulation went wrong in neurodevelopmental disorders: The example of Msi/Elavl RNA binding proteins 査読

    Masato Yano, Yoshika Hayakawa-Yano, Hideyuki Okano

    INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE   55   124 - 130   2016年12月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    RNA regulation participates in many aspects of brain development. There is substantial evidence that RNA dysregulation is critical in the pathogenesis of neurodevelopmental disorders, neurological diseases, and cancer. Several gene families encode RNA-binding proteins (RNABPs) that bind directly to RNA and orchestrate the post-transcriptional regulation of gene expression, including pre-mRNA splicing, stability, and poly(A) site usage. Among neural RNABPs, the Elavl and Msi families are the focus of neuronal development research owing to their hierarchical expression pattern: Msi1 is expressed in neural progenitor/stem cells, Elavl2 is expressed in early neuronal progenitors to mature neurons, and Elavl3/4 expression begins slightly later, during cortical neuron development. Traditional biochemical analyses provide mechanistic insight into RNA regulation by these RNABPs, and Drosophila and mouse genetic studies support a relationship between these RNABPs and several neurodevelopmental disorders. In addition, a recent cohort analysis of the human genome shows that genetic mutations and SNPs in these RNABPs are associated with various neurological disorders. Newly emerged technologies assess transcriptome-wide RNA-protein interactions in vivo. These technologies, combined with classical genetics methods, provide new insight into Elavl and Msi, not only with respect to their neurodevelopmental functions, but also their roles in several diseases. We review recent discoveries related to the two RNABP families in brain development and disease. (C) 2016 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.ijdevneu.2016.01.002

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  • Nova2 Regulates Neuronal Migration through an RNA Switch in Disabled-1 Signaling 査読

    Masato Yano, Yoshika Hayakawa-Yano, Aldo Mele, Robert B. Darnell

    NEURON   66 ( 6 )   848 - 858   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CELL PRESS  

    Neuronal migration leads to a highly organized laminar structure in the mammalian brain, and its misregulation causes lissencephaly and behavioral and cognitive defects. Reelin signaling, which is mediated in part by a key adaptor, disabled-1 (Dab1), plays a critical but incompletely understood role in this process. We found that the neuron-specific RNA-binding protein Nova2 regulates neuronal migration in late-generated cortical and Purkinje neurons. An unbiased HITS-CLIP and exon junction array search for Nova-dependent reelin-pathway RNAs at E14.5 revealed only one candidate-an alternatively spliced isoform of Dab1 (Dab1.7bc). In utero electroporation demonstrated that Dab1.7bc was sufficient to induce neuronal migration defects in wild-type mice and exacerbate defects when Dab1 levels were reduced, whereas Dab1 overexpression mitigates defects in Nova2 null mice. Thus, Nova2 regulates an RNA switch controlling the ability of Dab1 to mediate neuronal responsiveness to reelin signaling and neuronal migration, suggesting new links between splicing regulation, brain disease, and development.

    DOI: 10.1016/j.neuron.2010.05.007

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  • Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord. 査読 国際誌

    Yoshika Hayakawa-Yano, Keigo Nishida, Shinichi Fukami, Yukiko Gotoh, Toshio Hirano, Toshiyuki Nakagawa, Takuya Shimazaki, Hideyuki Okano

    Stem cells (Dayton, Ohio)   25 ( 6 )   1410 - 22   2007年6月

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    担当区分:筆頭著者   記述言語:英語  

    Gab1 (Grb2 associated binder1) has been identified as an adaptor molecule downstream of many growth factors, including epidermal growth factor (EGF), fibroblast growth factor, and platelet-derived growth factor, which have been shown to play crucial roles as mitotic signals for a variety of neural progenitor cells, including stem cells, both in vitro and in vivo. Here, we show that Gab1 deficiency results in a reduction in the number of Olig2-positive (Olig2(+)) progenitor cells in the developing mouse spinal cord after embryonic day 12.5 (E12.5), when gliogenesis starts in the pMN domain where the EGF receptor (EGFR) is expressed predominantly. Our in vitro analysis further revealed that Gab1 is essential for EGF-dependent proliferation of Olig2(+) progenitor cells derived from the E12.5 ventral and E14.5 dorsal but not ventral spinal cord, whereas Gab1 is always required for the activation of Akt1 but not of ERK1/2. Moreover, we found that the action of the Gab1/Akt pathway is context-dependent, since constitutively active Akt1 could rescue the proliferation defect only in the E12.5 spinal cord of the Gab1-deficient mouse in vitro. Finally, we demonstrated that EGFR-deficient mice and Gab1-deficient mice showed a similar reduction in the number of Olig2(+) progenitor cells in the developing spinal cord. These findings indicate that EGFR-mediated signaling through Gab1/Akt contributes to the sufficient expansion of Olig2(+) progenitor cells in a spatiotemporally regulated manner, which represents the origin of glial cells in the developing spinal cord. Disclosure of potential conflicts of interest is found at the end of this article.

    DOI: 10.1634/stemcells.2006-0584

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  • Expression and localization of Cayman ataxia-related protein, Caytaxin, is regulated in a developmental- and spatial-dependent manner 査読

    Yoshika Hayakawa, Masanori Itoh, Aiko Yamada, Teruhiko Mitsuda, Toshiyuki Nakagawa

    Brain Research   1129   100 - 109   2007年1月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.brainres.2006.10.068

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  • Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax 査読

    Masashi Ueda, Shimo Li, Masanori Itoh, Yoshika Hayakawa-Yano, Miao-xing Wang, Miki Hayakawa, Ryoko Has Ebe-Matsubara, Kazunori Ohta, Eri Ohta, Akihito Mizuno, Yoko Hida, Munekazu Matsumoto, Huayue Chen, Toshiyuki Nakagawa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   443 ( 4 )   1232 - 1238   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    The endoplasmic reticulum (ER) plays a pivotal role in cellular functions such as the ER stress response. However, the effect of the ER membrane on caspase activation remains unclear. This study reveals that polyglutamine oligomers augmented at ER induce insertion of Bax into the ER membrane, thereby activating caspase-7. In line with the role of ER in cell death induced by polyglutamine expansion, the ER membrane was found to be disrupted and dilated in the brain of a murine model of Huntington's disease. We can conclude that polyglutamine expansion may drive caspase-7 activation by disrupting the ER membrane. (C) 2013 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.bbrc.2013.12.114

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  • Ri/Nova gene-associated paraneoplastic subacute motor neuronopathy. 査読

    Younger DS, Graber J, Hayakawa-Yano Y, Parveen S, Frank M, Darnell RB

    Muscle & nerve   47 ( 4 )   617 - 618   2013年4月

  • Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system 査読

    Shimo Li, Yoshika Hayakawa-Yano, Masanori Itoh, Masashi Ueda, Kazunori Ohta, Yoshihiro Suzuki, Akihito Mizuno, Eri Ohta, Yoko Hida, Miao-xing Wang, Toshiyuki Nakagawa

    BRAIN RESEARCH   1488   1 - 13   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Prune homolog 2 (Drosophila) (PRUNE2) encodes a BCH motif-containing protein that shares homology with the Cayman ataxia-related protein Caytaxin. Caytaxin is a substrate of caspase-3 and is specifically expressed at the presynapse of vesicular-type glutamate transporter (VGLUT)-positive neurons, where it plays a role in glutamate neurotransmission primarily in the cerebellum and hippocampus. Here, we showed that a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol, similar to Caytaxin. However, the isoform is expressed predominantly in the olfactory bulb and layer la of the piriform cortex, where Caytaxin is scarcely expressed. The isoform expression is upregulated during development, similar to that in the presynaptic-localizing proteins Synapsin I and Bassoon. Prune2 and its previously identified isoforms have been shown to be a susceptibility gene for Alzheimer's disease, a biomarker for leiomyosarcomas, a proapoptotic protein, and an antagonist of cellular transformation. In addition, a novel isoform may develop new roles for Prune2 at the synapse in olfactory systems. (C) 2012 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.brainres.2012.10.001

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  • Cayman Ataxia-Related Protein is a Presynapse-Specific Caspase-3 Substrate 査読

    Masanori Itoh, Shimo Li, Kazunori Ohta, Aiko Yamada, Yoshika Hayakawa-Yano, Masashi Ueda, Yoko Hida, Yoshihiro Suzuki, Eri Ohta, Akihito Mizuno, Yoshiko Banno, Toshiyuki Nakagawa

    Neurochemical Research   36 ( 7 )   1304 - 1313   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Caspase plays an important role in apoptosis and physiological processes such as synaptic plasticity. However, the caspase substrate at the synapse is still unknown. Here we used an in vitro cleavage assay with a small-pool human brain cDNA library. We identified the presynaptic protein Caytaxin as a substrate of caspase-3 and caspase-7. Deficiency in Caytaxin causes Cayman ataxia, a disorder characterized by cerebellar dysfunction and mental retardation. Caytaxin cleavage in cerebellar granule neurons is dependent on caspase-3 activation. The cleavage site is upstream of the cellular retinal and the TRIO guanine exchange factor domain, producing a C-terminal fragment that may play an alternative role in inhibiting MEK2 signaling. Thus, we concluded that Caytaxin is a novel substrate of caspase-3 at the presynapse.

    DOI: 10.1007/s11064-011-0430-5

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    その他リンク: http://link.springer.com/article/10.1007/s11064-011-0430-5/fulltext.html

  • Cellular Composition and Organization of the Subventricular Zone and Rostral Migratory Stream in the Adult and Neonatal Common Marmoset Brain 査読

    Kazunobu Sawamoto, Yuki Hirota, Clara Alfaro-Cervello, Mario Soriano-Navarro, Xiaoping He, Yoshika Hayakawa-Yano, Masayuki Yamada, Keigo Hikishima, Hidenori Tabata, Akio Iwanami, Kazunori Nakajima, Yoshiaki Toyama, Toshio Itoh, Arturo Alvarez-Buylla, Jose Manuel Garcia-Verdugo, Hideyuki Okano

    JOURNAL OF COMPARATIVE NEUROLOGY   519 ( 4 )   690 - 713   2011年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-LISS  

    The adult subventricular zone (SVZ) of the lateral ventricle contains neural stem cells. In rodents, these cells generate neuroblasts that migrate as chains toward the olfactory bulb along the rostral migratory stream (RMS). The neural-stem-cell niche at the ventricular wall is conserved in various animal species, including primates. However, it is unclear how the SVZ and RMS organization in nonhuman primates relates to that of rodents and humans. Here we studied the SVZ and RMS of the adult and neonatal common marmoset (Callithrix jacchus), a New World primate used widely in neuroscience, by electron microscopy, and immunohistochemical detection of cell-type-specific markers. The marmoset SVZ contained cells similar to type B, C, and A cells of the rodent SVZ in their marker expression and morphology. The adult marmoset SVZ had a three-layer organization, as in the human brain, with ependymal, hypocellular, and astrocyte-ribbon layers. However, the hypocellular layer was very thin or absent in the adult-anterior and neonatal SVZ. Anti-PSA-NCAM staining of the anterior SVZ in whole-mount ventricular wall preparations of adult marmosets revealed an extensive network of elongated cell aggregates similar to the neuroblast chains in rodents. Time-lapse recordings of marmoset SVZ explants cultured in Matrigel showed the neuroblasts migrating in chains, like rodent type A cells. These results suggest that some features of neurogenesis and neuronal migration in the SVZ are common to marmosets, humans, and rodents. This basic description of the adult and neonatal marmoset SVZ will be useful for future studies on adult neurogenesis in primates. J. Comp. Neurol. 519:690-713, 2011. (C) 2010 Wiley-Liss, Inc.

    DOI: 10.1002/cne.22543

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  • Autophagy impairment stimulates PS1 expression and gamma-secretase activity. 査読 国際誌

    Kazunori Ohta, Akihito Mizuno, Masashi Ueda, Shimo Li, Yoshihiro Suzuki, Yoko Hida, Yoshika Hayakawa-Yano, Masanori Itoh, Eri Ohta, Masuko Kobori, Toshiyuki Nakagawa

    Autophagy   6 ( 3 )   345 - 52   2010年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Gamma-secretase plays an important role in the development of Alzheimer disease (AD). Gamma-secretase activity is enriched in autophagic vacuoles and it augments amyloid-beta (Abeta) synthesis. Autophagy-lysosomal dysfunction has been implicated in AD, but whether gamma-secretase activity is affected by autophagy remains unclear. Here we report that gamma-secretase activity is enhanced in basal autophagy-disturbed cells through the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) kinase, general control nonderepressible 2 (GCN2). Presenilin-1 (PS1) expression was increased even in the presence of nutrients in autophagy-related 5 knockdown (Atg5KD) human embryonic kidney (HE K293) cells expressing a short hairpin RNA as well as in chloroquine-treated HE K293 cells. However, PS1 expression induction was prevented in GCN2KD and ATF4KD cells. Furthermore, Atg5KD cells showed an increase in Abeta production and Notch1 cleavage. These were reduced by an autophagy inducer, resveratrol. Thus, we conclude that the autophagy-lysosomal system regulates gamma-secretase activity through GCN2.

    DOI: 10.4161/auto.6.3.11228

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  • An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor 査読

    Yoshihiro Suzuki, Kazunori Ohta, Masanori Itoh, Yukari Sakoh-Sumitomo, Teruhiko Mitsuda, Masashi Ueda, Yoshika Hayakawa-Yano, Shimo Li, Yoko Hida, Takashi Inuzuka, Yong-Keun Jung, Toshiyuki Nakagawa

    FEBS LETTERS   583 ( 9 )   1403 - 1408   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The gamma-secretase, composed of presenilin-1 (PS1) or presenilin-2 (PS2), nicastrin (NCT), anterior pharynx-defective phenotype 1 (APH-1), and PEN-2, is critical for the development of Alzheimer's disease (AD). PSs are autoproteolytically cleaved, producing an N-terminal fragment (NTF) and a hydrophilic loop domain-containing C-terminal fragment. However, the role of the loop domain in the gamma-secretase complex assembly remains unknown. Here, we report a novel PS2 isoform generated by alternative splicing, named PS2 beta, which is composed of an NTF with a hydrophilic loop domain. PS2 beta disturbed the interaction between NCT and APH-1, resulting in the inhibition of amyloid-beta production. We concluded that PS2 beta may inhibit gamma-secretase activity by affecting the gamma-secretase complex assembly.

    DOI: 10.1016/j.febslet.2009.04.014

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  • ATF4 regulates γ-secretase activity during amino acid imbalance 査読

    Teruhiko Mitsuda, Yoshika Hayakawa, Masanori Itoh, Kazunori Ohta, Toshiyuki Nakagawa

    Biochemical and Biophysical Research Communications   352 ( 3 )   722 - 727   2007年1月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.bbrc.2006.11.075

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  • Retinoic acid influences the development of the inferior olivary nucleus in the rodent

    Miyuki Yamamoto, Masahiro Fujinuma, Shinji Hirano, Yoshika Hayakawa, Margaret Clagett-Dame, Jinghua Zhang, Peter McCaffery

    Developmental Biology   280 ( 2 )   421 - 433   2005年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.ydbio.2005.02.007

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  • The RNA-binding protein HuD regulates neuronal cell identity and maturation 査読

    W. Akamatsu, H. Fujihara, T. Mitsuhashi, M. Yano, S. Shibata, Y. Hayakawa, H. J. Okano, S.-i. Sakakibara, H. Takano, T. Takano, T. Takahashi, T. Noda, H. Okano

    Proceedings of the National Academy of Sciences   102 ( 12 )   4625 - 4630   2005年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Proceedings of the National Academy of Sciences  

    DOI: 10.1073/pnas.0407523102

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  • Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1 査読

    Hiroyuki Ohba, Tatsuyuki Chiyoda, Emmy Endo, Masato Yano, Yoshika Hayakawa, Masanori Sakaguchi, Robert B. Darnell, Hirotaka J. Okano, Hideyuki Okano

    Neuroscience Letters   358 ( 3 )   157 - 160   2004年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.neulet.2004.01.026

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  • A critical period for retinoic acid teratogenesis and loss of neurophilic migration of pontine nuclei neurons 査読

    M. Yamamoto, J. Zhang, D. Smith, Y. Hayakawa, P. McCaffery

    Mechanisms of Development   120 ( 6 )   701 - 709   2003年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0925-4773(03)00047-9

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  • Genetic and environmental factors affecting peak bone mass in healthy Japanese women. 査読

    Hayakawa Y, Yanagi H, Hara S, Amagai H, Endo K, Hamaguch H, Tomura S

    Environmental Health and Preventive Medicine   6 ( 3 )   177 - 183   2001年10月

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    担当区分:筆頭著者   記述言語:英語  

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  • No Association found between the Ala54Thr Polymorphism of FABP2 Gene and Obesity and Obesity with Dyslipidemia in Japanese Schoolchildren 査読

    Kazue Endo, Hisako Yanagi, Chiaki Hirano, Yoshika Hayakawa, Hideo Hamaguchi, Shigeo Tomura

    Journal of Atherosclerosis and Thrombosis   8 ( 3 )   80 - 83   2001年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    DOI: 10.5551/jat1994.8.80

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MISC

  • 【ノンコーディングRNAテキストブック 最新の医学・創薬研究、方法論とマイルストーン論文200報】 (第4章)ncRNA研究をはじめよう RNP解析 CLIP CLIP技術の進化と今後の展開

    矢野 真人, 矢野 佳芳

    実験医学   33 ( 20 )   3419 - 3423   2015年12月

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    記述言語:日本語   出版者・発行元:(株)羊土社  

    HITS-CLIP法はRNP(ribonucleoprotein)複合体の解析において中心的役割を担う技術として広くRNA研究分野で用いられるようになってきた。今回は、CLIPの方法原理と最新技術について触れることでRNP複合体解析研究の今後の展開についても考えてみたい。(著者抄録)

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  • HITS-CLIP法; トランスクリプトームワイド 蛋白質-RNA相互作用のin vivoフットプリンティング

    矢野真人, 矢野佳芳

    日本RNA学会HP   2014年12月

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  • Close Up実験法 HITS-CLIP法 タンパク質-RNA相互作用のゲノムワイドマッピング

    矢野 真人, 矢野 佳芳, 川, Darnell Robert B

    実験医学   29 ( 1 )   105 - 114   2011年1月

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    記述言語:日本語   出版者・発行元:(株)羊土社  

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  • γ-セクレターゼの活性を制御する新規プレセニリン2アイソフォームの解析

    鈴木 欣宏, 太田 和徳, 伊藤 正徳, 上田 昌史, 李 詩沫, 樋田 陽子, 酒向 ゆかり, 光田 輝彦, 矢野 佳芳, 犬塚 貴, 中川 敏幸

    臨床神経学   49 ( 12 )   1078 - 1078   2009年12月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • γ-セクレターゼ活性を制御する新規プレセニリン2アイソフォームの解析

    鈴木 欣宏, 酒向 ゆかり, 光田 輝彦, 矢野 佳芳, 川, 伊藤 正徳, 上田 昌史, 太田 和徳, 李 詩沫, 犬塚 貴, 中川 敏幸

    臨床神経学   47 ( 12 )   995 - 995   2007年12月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • 胎生期脊髄における時間的空間的に制御されたOlig2陽性神経系前駆細胞の増殖には、Gab1を介したEGFシグナルが必須である

    矢野 佳芳, 早川, 西田 圭吾, 深見 伸一, 後藤 由季子, 平野 俊夫, 島崎 琢也, 岡野 栄之

    Inflammation and Regeneration   27 ( 4 )   405 - 405   2007年7月

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    記述言語:日本語   出版者・発行元:日本炎症・再生医学会  

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共同研究・競争的資金等の研究

  • 脊髄運動ニューロン固有のRNA制御プログラムとALS病態の関連

    2019年 - 2022年

    文部科学省  科学研究費補助金(基盤研究(B)) 

    矢野真人

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    資金種別:競争的資金

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  • 希突起膠細胞分化におけるRNA代謝-脂質代謝フィードバックループ制御機構

    2019年 - 2021年

    文部科学省  科学研究費補助金(基盤研究(C)) 

    矢野佳芳

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    担当区分:研究代表者  資金種別:競争的資金

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  • Elavl2による脳内翻訳制御機構の解析

    2016年 - 2018年

    文部科学省  科学研究費補助金(基盤研究(C)) 

    矢野真人

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    資金種別:競争的資金

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  • グリア細胞におけるRNA制御機構の意義の解明

    2015年 - 2018年

    文部科学省  科学研究費補助金(特別研究員奨励費) 

    矢野佳芳

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    担当区分:研究代表者  資金種別:競争的資金

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  • シナプスにおける小脳運動失調症原因分子Caytaxinの機能解析

    2007年

    文部科学省  科学研究費補助金(若手研究(B)) 

    矢野佳芳

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    担当区分:研究代表者  資金種別:競争的資金

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  • 機能的スクリーニング法の確立による小胞体ストレス制御因子の網羅的探索・機能解析

    2005年 - 2006年

    文部科学省  科学研究費補助金(特定領域研究) 

    中川敏幸

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    資金種別:競争的資金

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  • 神経幹細胞の分化における制御機構の解明

    2002年 - 2004年

    文部科学省  科学研究費補助金(特別研究員奨励費) 

    矢野佳芳

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    担当区分:研究代表者  資金種別:競争的資金

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