Updated on 2026/08/24

写真a

 
SAITO Naoaki
 
Organization
Academic Assembly Institute of Medicine and Dentistry - Assistant Professor
Faculty of Dentistry Department of Dentistry Assistant Professor
Graduate School of Medicine, Dentistry and Health Sciences Medicine and Dentistry Assistant Professor
Title
Assistant Professor
▶ display Profile on researchmap
External link

Degree

  • 博士（歯学） ( 2016.3   新潟大学 )

Research Interests

  • 薬剤関連顎骨壊死

  • 口腔外科

  • 骨再生

  • 骨細胞

  • 間葉系幹細胞

  • 再生医療

  • 低酸素

Research Areas

  • Life Science / Surgical dentistry

Research History (researchmap)

  • Niigata University   Assistant Professor

    2019.4

    　 More details

  • Niigata University   Medical and Dental Hospital

    2018.4 - 2019.3

    　 More details

  • 富山県立中央病院   歯科口腔外科   医員

    2016.4 - 2018.3

    　 More details

  • Niigata University

    2015.4 - 2016.3

    　 More details

  • Niigata University   Medical and Dental Hospital

    2011.10 - 2012.3

    　 More details

  • 長岡赤十字病院   歯科口腔外科   臨床研修歯科医師

    2011.4 - 2011.9

    　 More details

▶ display all

Research History

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Assistant Professor

    2026.5

  • Niigata University   Tissue Regeneration and Reconstruction, Oral Life Science, Graduate School of Medical and Dental Sciences   Assistant Professor

    2026.5

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction   Assistant Professor

    2019.4

Education

  • Niigata University   Graduate School of Medical and Dental Sciences   Oral Life Science

    2012.4 - 2016.3

    　 More details

  • Niigata University   Faculty of Dentistry   School of Dentistry

    2006.4 - 2011.3

    　 More details

Professional Memberships

  • JAPANESE STOMATOLOGICAL SOCIETY

    　 More details

  • The Japanese Society for Jaw Deformities

    　 More details

  • 日本口腔顎顔面外傷学会

    　 More details

  • JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS

    　 More details

  • NIIGATA DENTAL SOCIETY

    　 More details

  • JAPANESE SOCIETY FOR BONE MORPHOMETRY

    　 More details

  • 日本顎顔面インプラント学会

    　 More details

▶ display all

Qualification acquired

  • 日本口腔外科学会認定　口腔外科認定医

  • Dentist

 

Papers

  • Bloom syndrome with mandibular gingival carcinoma: A case report

    Ryoko Takeuchi, Kenta Haga, Naoaki Saito, Takafumi Hayashi, Jun-ichi Tanuma, Akinori Funayama

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2026.9

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ajoms.2026.03.009

    researchmap

  • Early increased cell proliferation compensates subsequent hypoplasia of the ossicle. Reviewed International journal

    Katsushige Kawasaki, Maiko Kawasaki, Finsa Tisna Sari, Vanessa Utama, Alex Kesuma, Makoto Fukushima, Naoaki Saito, Daisuke Suda, Takehisa Kudo, Akira Fujita, Jun Nihara, Brunella Franco, Atsushi Ohazama

    Frontiers in cell and developmental biology   13   1627730 - 1627730   2025

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Ossicles are essential structures for normal sound conduction from the external environment to the inner ear. Proper formation of the ossicles is required for normal hearing, and ossicular deformities lead to hearing loss. We identified ossicular hypoplasia in mice with mesenchymal conditional deletion of the primary cilia molecule (Ofd1 fl ;Wnt1Cre and Ift88 fl/fl ;Wnt1Cre). Hh signaling activity and cell proliferation were significantly downregulated in ossicle primordia of Ofd1 fl ;Wnt1Cre mice from E11.5. To restore Hh signaling in Ofd1 fl ;Wnt1Cre mice, we crossed R26SmoM2 fl mice (a constitutively active form of Smo) with Ofd1 fl ;Wnt1Cre mice. Ossicular hypoplasia was partially rescued in Ofd1 fl ;Wnt1Cre;R26SmoM2 fl mice. However, Hh signaling activity was not restored after E11.5. Instead, Hh signaling activity and cell proliferation were significantly increased in Ofd1 fl ;Wnt1Cre;R26SmoM2 fl mice at E10.5, when these were not altered in Ofd1 fl ;Wnt1Cre mice. To confirm whether molecular changes at E10.5 rescue subsequent hypoplasia, SAG (agonist of Hh signaling) was applied to Ofd1 fl ;Wnt1Cre mice at E9.5. A similar rescue could be observed in Ofd1 fl ;Wnt1Cre mice with SAG application. Thus, early increased cell proliferation could compensate subsequent hypoplasia of ossicle formation. Our results may provide clues for possible future treatment in familial hearing loss due to hypoplasia of the ossicles.

    DOI： 10.3389/fcell.2025.1627730

    PubMed

    researchmap

  • Stability of the maxilla and mandible in patients with dentofacial deformities after multi-segmental Le Fort I osteotomy combined with sagittal split ramus osteotomy Reviewed

    Masaki Kasahara, Daichi Hasebe, Daisuke Suda, Hidenobu Sakuma, Naoaki Saito, Daisuke Saito, Jun Nihara, Tadaharu Kobayashi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2024.12

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2024.12.015

    researchmap

  • Satisfaction questionnaire survey after surgical orthodontic treatment in patients with jaw deformities Reviewed

    Rika Hayakawa, Daichi Hasebe, Masaki Kasahara, Kenta Haga, Eri Asami, Ryoko Takeuchi, Naoaki Saito, Daisuke Saito, Hidenobu Sakuma, Tadaharu Kobayashi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2024.10

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2024.10.001

    researchmap

  • Investigation of orthognathic surgery indicators-combination with index of orthognathic functional treatment needs (IOFTN) and maxillofacial morphometric analysis. Reviewed International journal

    Zhuoyang Zheng, Daichi Hasebe, Daisuke Suda, Naoaki Saito, Daisuke Saito, Jun Nihara, Kaname Nohno, Isao Saito, Tadaharu Kobayashi

    Oral and maxillofacial surgery   28 ( 3 )   1189 - 1196   2024.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: The aim of this retrospective study was to determine orthognathic surgery indicators for Japanese patients with jaw deformities using both Index of Orthognathic Functional Treatment Needs (IOFTN) and maxillofacial morphometric analysis. SUBJECTS AND METHODS: The subjects were 89 patients treated with orthognathic surgery and 92 patients treated with orthodontic treatment alone, and were classified as class I, II, or III according to the ANB angle. Based on the results for IOFTN and the results of cephalometric analysis, the indication criteria for orthognathic surgery were examined. RESULTS: In IOFTN analysis, none of patients in the orthognathic surgery group were classified as category 1 or 2, while 48% of the patients in the orthodontic treatment group were classified as category 4 or 5. The results of the cephalometric analysis of patients in classified categories 4 and 5 showed that the orthognathic surgery group had significantly greater lateral mandibular deviation in Class I cases, significantly more severe degree of mandibular retrusion in Class II cases, and significantly more severe degree of mandibular prognathism in Class III cases. The results of the logistic regression analysis showed that IOFTN was a common variable as an indication criterion for orthognathic surgery, and several different variables were also selected from the cephalometric measurements in each group. CONCLUSION: IOFTN is a highly sensitive and useful indicator as a criterion for orthognathic surgery. However, in the choice of treatment strategy, maxillofacial morphometric analyses and the patient's desired goal are important.

    DOI： 10.1007/s10006-024-01243-0

    PubMed

    researchmap

  • 顎変形症患者に対する外科的矯正治療後のアンケート調査

    早川 里佳, 長谷部 大地, 笠原 公輝, 羽賀 健太, 浅見 栄里, 竹内 涼子, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 小林 正治

    日本口腔科学会雑誌   73 ( 2 )   92 - 93   2024.9

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 咬合接触検査とウェアラブルデバイスによる咀嚼検査を活用した顎変形症患者における咀嚼行動の評価

    マウン・ミョーマウン, 竹内 涼子, 羽賀 健太, 須田 大亮, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 長谷部 大地, 小林 正治

    日本口腔科学会雑誌   73 ( 2 )   216 - 216   2024.9

    　More details

    Language：English   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 骨性癒着した上顎犬歯を有する顎変形症患者に歯槽骨延長術を組み合わせた外科的矯正治療を施行した1例

    竹内 涼子, 須田 大亮, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 長谷部 大地, 竹山 雅規, 小林 正治

    日本顎変形症学会雑誌   34 ( 2 )   116 - 116   2024.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • Extensive ameloblastic fibroma of the mandible in an elderly woman: A case report and review of the literature

    Kenta Haga, Akinori Funayama, Manabu Yamazaki, Satoshi Maruyama, Taichi Hara, Naoaki Saito, Daisuke Saito, Yohei Sotsuka, Takafumi Hayashi, Jun-ichi Tanuma, Tadaharu Kobayashi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   36 ( 3 )   333 - 340   2024.5

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2023.08.003

    researchmap

  • 当科における顎変形症患者に対する外科的矯正治療後のアンケート調査

    早川 里佳, 長谷部 大地, 笠原 公輝, 羽賀 健太, 浅見 栄里, 竹内 涼子, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 小林 正治

    日本口腔科学会雑誌   73 ( 1 )   31 - 31   2024.3

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 幼児期の下顎骨関節突起骨折により発症した顔面非対称に対して外科的矯正治療を施行した1例 Reviewed

    齋藤 直朗, 須田 大亮, 齋藤 大輔, 佐久間 英伸, 長谷部 大地, 窪田 道男, 小林 正治

    日本顎変形症学会雑誌   33 ( 4 )   268 - 274   2023.12

    　More details

    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(NPO)日本顎変形症学会  

    症例は初診時14歳女児で、4歳時に階段からの転落により右側下顎骨関節突起骨折を生じ、成長とともに咬合の偏位がみられたため矯正歯科紹介となった。外科的矯正治療の適応と判断されたが、成長スパートの完了を待って当科紹介受診となった。右側上下顎の垂直的劣成長に伴う顔面非対称と診断し、術前矯正治療を開始、16歳時にLe Fort I型骨切り術および両側下顎市場分割術を施行した。術翌日のパノラマX線写真では、右側下顎枝部において遠位骨片の前下方移動による伸長が確認されたが、下顎頭の下方移動も伴っていた。術後は翌日より14日間のワイヤーによる顎間固定を行い、16日目に退院となった。術後6ヵ月のCT所見および顔貌でも顎骨形態の対称性が改善し、明らかな下顎頭の吸収像も認められなかった。

    researchmap

    Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J03047&link_issn=&doc_id=20231228220002&doc_link_id=10.5927%2Fjjjd.33.268&url=https%3A%2F%2Fdoi.org%2F10.5927%2Fjjjd.33.268&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • Evaluation of oral health-related quality of life in patients with temporomandibular disorders. Reviewed International journal

    Norio Onoda, Toshihiko Mikami, Naoaki Saito, Tadaharu Kobayashi

    Cranio : the journal of craniomandibular practice   41 ( 6 )   486 - 493   2023.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Objective: To evaluate oral health-related quality of life (OHRQoL) in patients with temporomandibular disorders (TMDs).Methods: Subjects included 56 patients diagnosed with TMD. Control subjects consisted of 30 individuals without temporomandibular joint symptoms. OHRQoL was evaluated using the Japanese version of the Oral Health Impact Profile (OHIP-J54) before and 4 months after treatment.Results: Total score and all subscale scores of the OHIP-J54 in patients before treatment were significantly higher than those of the control subjects and were significantly improved after treatment, except for social disability. Gender and NRS pain scores had statistically significant effects on OHRQoL, which was low in females and patients with severe pain.Conclusion: OHIP-J54 appeared to be useful for understanding psychological and social problems as a screening tool and for assessing the extent of changes in the well-being of patients with TMD.

    DOI： 10.1080/08869634.2021.1883378

    PubMed

    researchmap

  • 過去20年間に当科を受診した悪性腫瘍患者の動向と疾病病態 Reviewed

    船山 昭典, 三上 俊彦, 新美 奏恵, 芳澤 享子, 羽賀 健太, 齋藤 大輔, 長谷部 大地, 佐久間 英伸, 齋藤 直朗, 須田 大亮, 竹内 涼子, 原 太一, 小林 正治

    新潟歯学会雑誌   53 ( 1 )   17 - 23   2023.6

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • Changes in nutritional status of patients with jaw deformities due to orthognathic surgery. Reviewed International journal

    Yoshinori Inaba, Daichi Hasebe, Kosuke Hashizume, Daisuke Suda, Naoaki Saito, Daisuke Saito, Hidenobu Sakuma, Akinori Funayama, Tadaharu Kobayashi

    Oral surgery, oral medicine, oral pathology and oral radiology   135 ( 3 )   347 - 354   2023.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    OBJECTIVE: In orthognathic surgery, it is important to carefully manage peri-operative nutrition because maxillomandibular fixation and problems such as swelling and pain after surgery may make it difficult to eat normally and may prevent adequate nutrition. This study investigated the changes in nutritional status of patients with jaw deformities due to orthognathic surgery. STUDY DESIGN: The subjects were 155 jaw deformity patients, who underwent orthognathic surgery. The nutritional status was evaluated using anthropometry immediately before and 10 days after surgery and clinical laboratory results and the controlling nutritional status (CONUT) score before surgery and immediately, 1 week and >6 months after surgery. We investigated the relationship among the nutritional status, surgical procedures, and dietary intake in patients who underwent orthognathic surgery. RESULTS: The surgical procedure time and amount of bleeding were significantly greater as the surgical procedure became more complex. All of the laboratory values and CONUT scores were significantly decreased immediately after surgery and then increased over time, recovering to the same level as before surgery except for serum albumin at >6 months after surgery. CONCLUSIONS: Nutritional management is considered as one of the key factors for the better and faster recovery after the orthognathic surgery.

    DOI： 10.1016/j.oooo.2022.07.007

    PubMed

    researchmap

  • 口底部に生じた異所性胃腸管嚢胞の1例 Reviewed

    齋藤 直朗, 丸山 智, 加藤 祐介, 竹内 涼子, 田沼 順一, 小林 正治

    日本口腔外科学会雑誌   69 ( 1 )   27 - 31   2023.1

    　More details

    Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(公社)日本口腔外科学会  

    4歳5ヵ月女児。既往として出生前診断で指摘されていた口底部の嚢胞様病変に対し、生後3日に開窓術が施行され、病理組織学的に類表皮嚢胞と診断された。今回、3歳9ヵ月時に開窓部からの出血を主訴に当科へ受診となった。数日後に出血が治まったため、いったん終診となったが、4歳2ヵ月頃より唾仙痛様症状が出現したため再診した。口腔内所見および画像所見を踏まえて、開窓術後の変化を伴う口底部類表皮嚢胞と診断され、5歳時に全身麻酔下で嚢胞摘出術が行われた。その結果、病理組織学的に異所性胃腸管嚢胞と確定診断された。術後3年経過現在、再発なく、経過良好である。

    researchmap

    Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01073&link_issn=&doc_id=20230201450005&doc_link_id=10.5794%2Fjjoms.69.27&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.69.27&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • The use of an ultrasonic curettage device in orthognathic surgery decreases surgery-related blood loss. Reviewed International journal

    Hidenobu Sakuma, Daichi Hasebe, Ryoko Takeuchi, Taichi Hara, Daisuke Suda, Naoaki Saito, Daisuke Saito, Tadaharu Kobayashi

    Heliyon   8 ( 12 )   e12639 - e12639   2022.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    OBJECTIVE: This study aimed to compare the use of a powered instrument (PI) and ultrasonic curettage device (ULCD) with intraoperative blood loss (IOBL), drain volume (DV), calculated blood loss (CBL), and hidden blood loss (HBL) in orthognathic surgery. METHODS: We included 163 patients who underwent bimaxillary surgery in our department. CBL was calculated from the preoperative and postoperative hemoglobin levels using the "hemoglobin balance method." CBL is an indicator of the amount of perioperative blood loss. HBL was calculated by subtracting IOBL and DV from CBL. RESULTS: The PI group consisted of 61 patients (17 males and 44 females, age: 24.9 ± 9.5 years), and the ULCD group consisted of 102 patients (40 males and 62 females, age: 23.1 ± 7.8 years). In the PI group, the median IOBL, DV, CBL, and HBL were 540.0 (interquartile range [IQR] 380.0-670.0), 113.0 (IQR 77.0-147.0), 1000.0 (IQR 751.4-1248.6), and 285.8 (IQR 151.0-476.4) ml, respectively. In the ULCD group, the median IOBL, DV, CBL, and HBL were 327.5 (IQR 200.0-455.0), 105.5 (IQR 75.3-136.0), 759.5 (IQR 594.9-944.2), and 294.2 (IQR 120.8-456.9) ml, respectively. IOBL and CBL were significantly reduced with ULCD use, but no significant differences were observed in DV and HBL. CONCLUSIONS: This study showed that IOBL decreased with ULCD use, resulting in a decrease in CBL. Conversely, bleeding parameters (DV and HBL), which reflect the amount of bleeding that occurs after wound closure, did not show a decrease with ULCD use.

    DOI： 10.1016/j.heliyon.2022.e12639

    PubMed

    researchmap

  • Migration and phenotype switching of macrophages at early-phase of bone-formation by secretomes from bone marrow derived mesenchymal stem cells using rat calvaria bone defect model. Reviewed International journal

    Wataru Katagiri, Ryoko Takeuchi, Naoaki Saito, Daisuke Suda, Tadaharu Kobayashi

    Journal of dental sciences   17 ( 1 )   421 - 429   2022.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jds.2021.08.012

    Scopus

    PubMed

    researchmap

  • Maxillary sinus aspergillosis associated with migration of a dental implant: A case report Reviewed

    Wataru Katagiri, Kosuke Hashizume, Naoaki Saito, Akinori Funayama, Tadaharu Kobayashi

    Advances in Oral and Maxillofacial Surgery   4   100157 - 100157   2021.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.adoms.2021.100157

    researchmap

  • Evaluation of masticatory efficiency in patients with jaw deformities using the gummy jelly method Reviewed

    Hidenobu Sakuma, Daishuke Suda, Taichi Hara, Naoaki Saito, Daishuke Saito, Daichi Hasebe, Wataru Katagiri, Tadaharu Kobayashi

    Advances in Oral and Maxillofacial Surgery   100166 - 100166   2021.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.adoms.2021.100166

    researchmap

  • A comparison and evaluation of the use of ultrasonic cutting devices with conventional powered instruments in orthognathic surgery Reviewed

    Yusuke Kato, Naoaki Saito, Kanae Niimi, Daisuke Saito, Hidenobu Sakuma, Daichi Hasebe, Wataru Katagiri, Tadaharu Kobayashi

    Advances in Oral and Maxillofacial Surgery   100081 - 100081   2021.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.adoms.2021.100081

    researchmap

  • Metabolomic Alteration of Oral Keratinocytes and Fibroblasts in Hypoxia. Reviewed International journal

    Hiroko Kato, Masahiro Sugimoto, Ayame Enomoto, Miku Kaneko, Yuko Hara, Naoaki Saito, Aki Shiomi, Hisashi Ohnuki, Kenji Izumi

    Journal of clinical medicine   10 ( 6 )   1156 - 1156   2021.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：{MDPI} {AG}  

    The oxygen concentration in normal human tissue under physiologic conditions is lower than the atmospheric oxygen concentration. The more hypoxic condition has been observed in the cells with wound healing and cancer. Somatic stem cells reside in a hypoxic microenvironment in vivo and prefer hypoxic culture conditions in vitro. Oral mucosa contains tissue-specific stem cells, which is an excellent tissue source for regenerative medicine. For clinical usage, maintaining the stem cell in cultured cells is important. We previously reported that hypoxic culture conditions maintained primary oral keratinocytes in an undifferentiated and quiescent state and enhanced their clonogenicity. However, the metabolic mechanism of these cells is unclear. Stem cell biological and pathological findings have shown that metabolic reprogramming is important in hypoxic culture conditions, but there has been no report on oral mucosal keratinocytes and fibroblasts. Herein, we conducted metabolomic analyses of oral mucosal keratinocytes and fibroblasts under hypoxic conditions. Hypoxic oral keratinocytes and fibroblasts showed a drastic change of metabolite concentrations in urea cycle metabolites and polyamine pathways. The changes of metabolic profiles in glycolysis and the pentose phosphate pathway under hypoxic conditions in the oral keratinocytes were consistent with those of other somatic stem cells. The metabolic profiles in oral fibroblasts showed only little changes in any pathway under hypoxia except for a significant increase in the antioxidant 2-oxoglutaric acid. This report firstly provides the holistic changes of various metabolic pathways of hypoxic cultured oral keratinocytes and fibroblasts.

    DOI： 10.3390/jcm10061156

    PubMed

    researchmap

  • Conditioned medium from mesenchymal stem cells improves condylar resorption induced by mandibular distraction osteogenesis in a rat model. Reviewed International journal

    Wataru Katagiri, Satoshi Endo, Ryoko Takeuchi, Daisuke Suda, Naoaki Saito, Tadaharu Kobayashi

    Heliyon   7 ( 3 )   e06530   2021.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Condylar resorption (CR) after surgical orthognathic treatment is defined as dysfunctional remodeling of the temporomandibular joint manifested by morphological changes with decreased condylar head volume that cause occlusal and esthetic changes. Although both conservative and surgical treatment strategies have been employed for the treatment of CR, effective procedures have not been established till date. In this study, the effects of MSC-CM on CR were investigated. Bone marrow-derived MSCs of rats (rMSCs) were cultured until 80% confluent, cultured in serum-free conditioned medium for 48 h; the collected medium was defined as MSC-CM. Osteogenesis, chondrogenesis, and angiogenesis-related gene expression in rMSCs cultured with MSC-CM was evaluated by quantitative real-time polymerase chain reaction. A rat CR model was used for animal studies, in which CR occurred after mandibular distraction osteogenesis for 10 days. MSC-CM was injected via the tail vein and quantitative and qualitative evaluations were performed by micro-computed tomography (micro-CT) and histology. MSC-CM enhanced osteogenesis-, chondrogenesis-, and angiogenesis-related gene expression in rMSCs. Micro-CT showed CR in control groups; however, it was observed to be improved in the MSC-CM group. Histologically, an enlarged cartilage layer was seen in the MSC-CM group, while cartilage layers had almost thinned or disappeared in control groups. These results indicate that MSC-CM improved CR.

    DOI： 10.1016/j.heliyon.2021.e06530

    PubMed

    researchmap

  • Distinct differences in hypoxic responses between human oral mucosa and skin fibroblasts in a 3D collagen matrix. Reviewed International journal

    Yuko Hara-Saito, Hiroko Kato, Naoaki Saito, Aki Shiomi, Atsushi Uenoyama, Ritsuo Takagi, Kenji Izumi

    In vitro cellular & developmental biology. Animal   56 ( 6 )   452 - 479   2020.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11626-020-00458-1

    Scopus

    PubMed

    researchmap

  • Orthognathic surgery for patients with venous thromboembolism during treatment: Two case reports Reviewed

    Yusuke Kato, Daisuke Saito, Daisuke Suda, Naoaki Saito, Daichi Hasebe, Kanae Niimi, Wataru Katagiri, Tadaharu Kobayashi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   32 ( 6 )   462 - 465   2020

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ajoms.2020.06.011

    Scopus

    researchmap

  • A case of renal cell carcinoma metastasis to the upper gingiva Reviewed

    Naoaki Saito, Gentaro Takeuchi, Yusuke Asai, Tomoe Chuujoh, Taku Kojima, Tadaharu Kobayashi

    48 ( 2 )   29 - 34   2018.12

    　More details

    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

    researchmap

  • Vertical distraction osteogenesis of a reconstructed mandible with a free vascularized fibula flap: a report of two cases. Reviewed International journal

    Naoaki Saito, Akinori Funayama, Yoshiaki Arai, Daisuke Suda, Yoshiyuki Takata, Tadaharu Kobayashi

    Maxillofacial plastic and reconstructive surgery   40 ( 1 )   32 - 32   2018.12

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media {LLC}  

    Background: The free vascularized fibula flap presents many advantages such as sufficient length of the bony segment, good vascularization, better quality of the bone, and a long vascular pedicle, but it is also associated with some disadvantages with regard to prosthetic rehabilitation because of its limited height. Improvement in bone height is necessary for ideal dental implant treatment of reconstructed mandibles. Case presentation: For two squamous cell carcinoma patients, mandibular bone reconstruction was performed secondarily with the peroneal flap after tumor resection. Since the bone height was insufficient at the time of implant treatment, occlusion reconstruction by dental implant was performed after vertical distraction osteogenesis. Conclusions: Vertical distraction osteogenesis is a suitable treatment option for alveolar ridge deficiency resulting from fibula transplantation for mandibular reconstruction following tumor surgery.

    DOI： 10.1186/s40902-018-0172-2

    PubMed

    researchmap

  • Bulleidia extructa and Actinomyces israelii infections in a patient with brain abscess. Reviewed International journal

    Keiko Nakamura, Hiroyasu Kaya, Tsutomu Kobayashi, Naoaki Saito, Masahito Yamada

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology   39 ( 9 )   1641 - 1642   2018.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer-Verlag Italia s.r.l.  

    DOI： 10.1007/s10072-018-3436-9

    Scopus

    PubMed

    researchmap

  • Application of Hypoxic Exposure Combined with Osteogenic Induction for the Enhancement of Multiple Osteoinductive Capabilities in Rat Mesenchymal Cells Reviewed

    Naoaki Saito, Hiroko Kato, Yosuke Akiba, Yuko Hara, Taku Kojima, Michiko Yoshizawa, Atsushi Ohazama, Takeyasu Maeda, Tadaharu Kobayashi, Kenji Izumi

    Open Journal of Stomatology   8 ( 2 )   53 - 69   2018.2

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.4236/ojst.2018.82005

    researchmap

  • Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms. Reviewed International journal

    Maiko Kawasaki, Katsushige Kawasaki, Fumiya Meguro, Akane Yamada, Ryuichi Ishikawa, Thantrira Porntaveetus, James Blackburn, Yoko Otsuka-Tanaka, Naoaki Saito, Masato S Ota, Paul T Sharpe, John A Kessler, Joachim Herz, Martyn T Cobourne, Takeyasu Maeda, Atsushi Ohazama

    PloS one   13 ( 9 )   e0204126   2018

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0204126

    Scopus

    PubMed

    researchmap

  • Effects of C-xylopyranoside derivative on epithelial regeneration in an in vitro 3D oral mucosa model. Reviewed International journal

    Atsushi Uenoyama, Ikuko Kakizaki, Aki Shiomi, Naoaki Saito, Yuko Hara, Taro Saito, Hisashi Ohnuki, Hiroko Kato, Ritsuo Takagi, Takeyasu Maeda, Kenji Izumi

    Bioscience, biotechnology, and biochemistry   80 ( 7 )   1344 - 55   2016.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/09168451.2016.1153957

    Web of Science

    Scopus

    PubMed

    researchmap

  • 骨分化誘導と低酸素処理併用によるラット間葉系細胞の多面的骨誘導能促進効果の検討 Reviewed

    齋藤直朗

    新潟大学大学院   2016.3

    　More details

    Publishing type：Doctoral thesis  

    researchmap

  • Cyclic mechanical pressure-loading alters epithelial homeostasis in a three-dimensional in vitro oral mucosa model: clinical implications for denture-wearers Reviewed

    A. Shiomi, K. Izumi, A. Uenoyama, T. Saito, N. Saito, H. Ohnuki, H. Kato, M. Kanatani, S. Nomura, H. Egusa, T. Maeda

    JOURNAL OF ORAL REHABILITATION   42 ( 3 )   192 - 201   2015.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/joor.12254

    Web of Science

    Scopus

    PubMed

    researchmap

  • Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal cartilage in MMP-9-deficient mice. Reviewed

    Taku Kojima, Tomoka Hasegawa, Paulo Henrique Luiz de Freitas, Tomomaya Yamamoto, Muneteru Sasaki, Keisuke Horiuchi, Hiromi Hongo, Tamaki Yamada, Naoko Sakagami, Naoaki Saito, Michiko Yoshizawa, Tadaharu Kobayashi, Takeyasu Maeda, Chikara Saito, Norio Amizuka

    Biomedical research (Tokyo, Japan)   34 ( 3 )   119 - 28   2013.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2220/biomedres.34.119

    Web of Science

    Scopus

    PubMed

    researchmap

  • Clinico-statistical Survey of Outpatients and Inpatients in the Department of Oral Reconstructive Surgery Reviewed

    43 ( 1 )   37 - 42   2013.6

    　More details

    Authorship：Lead author,　Corresponding author   Language：Japanese  

    J-GLOBAL

    researchmap

  • Rat wild-type parathyroid hormone receptor (PTH-R) and mutant PTH-R(P132L) show the different intracellular localization in vitro. Reviewed

    Junko Shimomura-Kuroki, Sobhan Ubaidus, Paulo Hl Freitas, Minqi Li, Yoko Ishida, Naoaki Saito, Kimimitsu Oda, Shohachi Shimooka, Norio Amizuka

    Biomedical research (Tokyo, Japan)   29 ( 2 )   61 - 9   2008.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2220/biomedres.29.61

    Web of Science

    Scopus

    PubMed

    researchmap

▶ display all

MISC

  • 当科における上顎洞底挙上術の手術手技についての検討

    須田 大亮, 長谷部 大地, 齋藤 直朗, 竹内 涼子, 船山 昭典

    Japanese Journal of Maxillo Facial Implants   24 ( 3 )   255 - 255   2025.11

    　More details

    Language：Japanese   Publisher：(公社)日本顎顔面インプラント学会  

    researchmap

  • 新生女児に生じた先天性エプーリスの1例

    小林 雅, 羽賀 健太, 竹内 涼子, 須田 大亮, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 長谷部 大地, 丸山 智, 田沼 順一, 船山 昭典

    日本口腔科学会雑誌   74 ( 3 )   209 - 209   2025.9

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 卵巣摘出ラット下顎骨延長モデルを用いた副甲状腺ホルモン製剤間歇投与による下顎頭吸収抑制効果の検討

    笠原 公輝, 須田 大亮, 竹内 涼子, 齋藤 直朗, 船山 昭典, 小林 正治

    日本口腔科学会雑誌   74 ( 2 )   145 - 145   2025.7

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 再発のみられた単純性骨嚢胞様の空洞化を伴ったセメント質骨性異形成症の1例

    竹内 涼子, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 長谷部 大地, 新國 農, 林 孝文, 丸山 智, 田沼 順一, 船山 昭典

    日本口腔科学会雑誌   74 ( 2 )   141 - 141   2025.7

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 副甲状腺ホルモン製剤間歇的投与はラット下顎骨延長モデルにおける下顎頭吸収を抑制する

    笠原 公輝, 須田 大亮, 竹内 涼子, 齋藤 直朗, 船山 昭典, 小林 正治

    新潟歯学会雑誌   54 ( 2 )   106 - 106   2024.12

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • 下顎骨切除後の再建骨に対するインプラント補綴のための垂直的仮骨延長とGBRによる2段階骨増生

    松崎 奈々香, 高嶋 真樹子, 齋藤 直朗, 荒井 良明, 小林 正治

    新潟歯学会雑誌   53 ( 2 )   100 - 100   2024.1

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • 当科における顎変形症患者に対する外科的矯正治療後のアンケート調査

    早川里佳, 長谷部大地, 笠原公輝, 羽賀健太, 浅見栄里, 竹内涼子, 齋藤直朗, 齋藤大輔, 佐久間英伸, 小林正治

    日本口腔科学会雑誌(Web)   73 ( 1 )   2024

    　More details

  • 高エネルギー外傷による顎骨骨折変形治癒後の顎変形症に対する外科的矯正治療

    小林 正治, 齋藤 直朗, 船山 昭典, 新美 奏恵

    口腔顎顔面外傷   22 ( 2 )   113 - 113   2023.12

    　More details

    Language：Japanese   Publisher：日本口腔顎顔面外傷学会  

    researchmap

  • 高エネルギー外傷による顎骨骨折変形治癒後の顎変形症に対する外科的矯正治療

    小林 正治, 齋藤 直朗, 船山 昭典, 新美 奏恵

    口腔顎顔面外傷   22 ( 2 )   113 - 113   2023.12

    　More details

    Language：Japanese   Publisher：日本口腔顎顔面外傷学会  

    researchmap

  • 外科的治療によりインプラントの温存を試みたApical peri-implantitisの1例

    須田 大亮, 船山 昭典, 長谷部 大地, 齋藤 直朗, 竹内 涼子, 小林 正治

    Japanese Journal of Maxillo Facial Implants   22 ( 3 )   264 - 264   2023.11

    　More details

    Language：Japanese   Publisher：(公社)日本顎顔面インプラント学会  

    researchmap

  • IOFTNと顎顔面形態分析を併用した外科的矯正治療の適応に関する検証

    鄭 琢揚, 長谷部 大地, 竹内 涼子, 須田 大亮, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 丹原 惇, 齋藤 功, 小林 正治

    新潟歯学会雑誌   53 ( 1 )   44 - 44   2023.6

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • 顎矯正手術後の三叉神経障害に関する検討

    齋藤 直朗, 羽賀 健太, 竹内 涼子, 須田 大亮, 齋藤 大輔, 佐久間 英伸, 長谷部 大地, 小林 正治

    日本顎変形症学会雑誌   33 ( 2 )   203 - 203   2023.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • 下顎枝矢状分割術における術中異常骨折のリスク因子の検討

    長谷部 大地, 羽賀 健太, 竹内 涼子, 齋藤 直朗, 齋藤 大輔, 佐久間 英伸, 小林 正治

    日本顎変形症学会雑誌   33 ( 2 )   200 - 200   2023.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • 多分割Le Fort I型骨切り術の術後安定性の検討

    笠原公輝, 長谷部大地, 原太一, 須田大亮, 佐久間英伸, 齋藤直朗, 齋藤大輔, 齋藤功, 小林正治

    日本口腔科学会学術集会プログラム・抄録集   77th ( 2 )   63 - 63   2023

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    J-GLOBAL

    researchmap

  • Trends and pathogenesis of patients diagnosed with malignant tumors in the oral and maxillofacial region in our department during the past 20 years

    船山昭典, 三上俊彦, 三上俊彦, 新美奏恵, 新美奏恵, 芳澤享子, 羽賀健太, 齋藤大輔, 長谷部大地, 佐久間英伸, 齋藤直朗, 須田大亮, 竹内涼子, 原太一, 小林正治

    新潟歯学会雑誌   53 ( 1 )   17 - 23   2023

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 顎矯正手術における3DシミュレーションとCAD/CAMサージカルガイドプレートの有用性

    齋藤 大輔, 齋藤 直朗, 原 太一, 長谷部 大地, 片桐 渉, 小林 正治

    日本形成外科学会会誌   42 ( 11 )   687 - 687   2022.11

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 顎矯正手術における術式別Hidden blood lossの定量的評価と影響因子の調査

    佐久間 英伸, 原 太一, 竹内 涼子, 須田 大亮, 齋藤 直朗, 齋藤 大輔, 長谷部 大地, 片桐 渉, 小林 正治

    日本口腔科学会雑誌   71 ( 2 )   140 - 140   2022.7

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 顎矯正手術における3DシミュレーションとCAD/CAMサージカルガイドプレートならびに超音波切削機器の応用

    齋藤 大輔, 原 太一, 須田 大亮, 齋藤 直朗, 佐久間 英伸, 長谷部 大地, 片桐 渉, 小林 正治

    日本顎変形症学会雑誌   32 ( 2 )   158 - 158   2022.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • 顎矯正手術におけるHidden blood lossの術式と骨切削器による比較

    佐久間 英伸, 原 太一, 竹内 涼子, 須田 大亮, 齋藤 直朗, 齋藤 大輔, 長谷部 大地, 片桐 渉, 小林 正治

    日本顎変形症学会雑誌   32 ( 2 )   195 - 195   2022.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • 顎矯正手術による顎変形症患者の栄養状態の変化

    稲葉 好則, 須田 大亮, 齋藤 大輔, 齋藤 直朗, 佐久間 英伸, 長谷部 大地, 片桐 渉, 小林 正治

    新潟歯学会雑誌   51 ( 2 )   116 - 116   2021.12

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • 顎矯正手術におけるCAD/CAMサージカルガイドプレートの適用

    齋藤 大輔, 齋藤 直朗, 長谷川 健二, 原 太一, 須田 大亮, 佐久間 英伸, 長谷部 大地, 片桐 渉, 小林 正治

    新潟歯学会雑誌   51 ( 2 )   115 - 115   2021.12

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • エクスターナルヘキサゴンの破損に対応した2症例

    片桐 渉, 竹内 涼子, 橋爪 孝介, 齋藤 直朗, 須田 大亮, 長谷部 大地, 船山 昭典, 小林 正治

    Japanese Journal of Maxillo Facial Implants   20 ( 3 )   185 - 185   2021.11

    　More details

    Language：Japanese   Publisher：(公社)日本顎顔面インプラント学会  

    researchmap

  • 日本語版顎変形症疾患特異的QOL調査票のvalidity studyおよび健康関連QOLとの関連性の検討

    新美 奏恵, 齋藤 大輔, 須田 大亮, 原 太一, 齋藤 直朗, 長谷部 大地, 佐久間 英伸, 片桐 渉, 齋藤 功, 小林 正治

    日本口腔科学会雑誌   70 ( 2 )   170 - 170   2021.7

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • Effects of orthognathic surgery on nutritional status of patients with jaw deformities

    稲葉好則, 須田大亮, 橋爪孝介, 齋藤大輔, 齋藤直朗, 佐久間英伸, 長谷部大地, 片桐渉, 小林正治

    日本顎変形症学会雑誌   31 ( 2 )   105 - 105   2021

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Efforts to evaluate masticatory function in patients with jaw deformities using a food questionnaire

    佐久間英伸, 長谷部大地, 齋藤大輔, 齋藤直朗, 須田大亮, 原太一, 片桐渉, 小林正治

    日本顎変形症学会雑誌   31 ( 2 )   142 - 142   2021

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 外科的矯正治療にともなう顎関節症状と下顎頭形態の変化

    遠藤 諭, 加藤 祐介, 原 太一, 須田 大亮, 長谷部 大地, 佐久間 英伸, 齋藤 大輔, 齋藤 直朗, 新美 奏恵, 西山 秀昌, 片桐 渉, 林 孝文, 齋藤 功, 小林 正治

    新潟歯学会雑誌   50 ( 2 )   120 - 120   2020.12

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • 歯科インプラント迷入に併発した上顎洞アスペルギルス症の1例

    橋爪 孝介, 齋藤 直朗, 船山 昭典, 片桐 渉, 小林 正治

    Japanese Journal of Maxillo Facial Implants   19 ( 3 )   232 - 232   2020.11

    　More details

    Language：Japanese   Publisher：(公社)日本顎顔面インプラント学会  

    researchmap

  • 顎矯正手術における超音波骨切削機器鋸歯状ナイフチップセットの有用性

    加藤 祐介, 齋藤 直朗, 長谷部 大地, 佐久間 英伸, 新美 奏恵, 小林 正治

    日本形成外科学会会誌   40 ( 9 )   499 - 499   2020.9

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 進行性下顎頭吸収に対する骨髄間葉系幹細胞培養上清を用いた再生医学的予防・治療法の開発研究

    片桐 渉, 遠藤 諭, 竹内 涼子, 須田 大亮, 齋藤 直朗, 小林 正治

    日本顎変形症学会雑誌   30 ( 2 )   192 - 192   2020.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • 超音波切削器を用いた顎矯正手術におけるSerrated aggressive knifeチップの有用性

    加藤 祐介, 齋藤 直朗, 新美 奏恵, 佐久間 英伸, 長谷部 大地, 齋藤 大輔, 丹原 惇, 齋藤 功, 小林 正治

    日本顎変形症学会雑誌   30 ( 2 )   154 - 154   2020.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • 顎矯正手術施行前後における咀嚼機能の変化について

    佐久間 英伸, 長谷部 大地, 新美 奏恵, 齋藤 大輔, 齋藤 直朗, 須田 大亮, 片桐 渉, 齋藤 功, 小林 正治

    日本顎変形症学会雑誌   30 ( 2 )   161 - 161   2020.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • 幼児期下顎骨関節突起骨折術後の顎顔面非対称を伴う偏位咬合に対して外科的矯正治療を施行した1例

    齋藤 直朗, 船山 昭典, 新美 奏恵, 小林 正治

    口腔顎顔面外傷   18 ( 2 )   62 - 62   2019.10

    　More details

    Language：Japanese   Publisher：日本口腔顎顔面外傷学会  

    researchmap

  • 顎矯正手術におけるSerrated aggressive knifeチップの有用性の検証

    齋藤 直朗, 佐久間 英伸, 新美 奏恵, 長谷部 大地, 加藤 祐介, 齋藤 大輔, 竹内 涼子, 遠藤 諭, 片桐 渉, 小林 正治

    日本口腔科学会雑誌   68 ( 2 )   163 - 163   2019.7

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 顎変形症患者における形態的不調和と咀嚼機能との関連の解明

    佐久間 英伸, 長谷部 大地, 新美 奏恵, 加藤 祐介, 齋藤 大輔, 齋藤 直朗, 荻野 奈保子, 片桐 渉, 齋藤 功, 小林 正治

    日本顎変形症学会雑誌   29 ( 2 )   186 - 186   2019.5

    　More details

    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

    researchmap

  • 上顎歯肉に転移した腎細胞癌の1例

    齋藤 直朗, 竹内 玄太郎, 浅井 佑介, 中條 智恵, 小島 拓, 小林 正治

    新潟歯学会雑誌   48 ( 2 )   97 - 102   2018.12

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • 幹細胞培養上清・エクソソームを用いた骨再生医療の開発

    片桐 渉, 竹内 涼子, 遠藤 諭, 齋藤 直朗, 長谷部 大地, 船山 昭典, 小林 正治

    Japanese Journal of Maxillo Facial Implants   17 ( 3 )   216 - 216   2018.11

    　More details

    Language：Japanese   Publisher：(公社)日本顎顔面インプラント学会  

    researchmap

  • 用水路転落により受傷した顔面多発骨折の一例

    齋藤 直朗, 横林 康男, 中條 智恵

    新潟歯学会雑誌   46 ( 2 )   120 - 120   2016.12

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • ラット間葉系細胞の多面的骨誘導能に対する低酸素処理の効果に関する検討

    齋藤直朗, 齋藤直朗, 齋藤直朗, 泉健次, 秋葉陽介, 加藤寛子, 加藤寛子, 原夕子, 小島拓, 芳澤享子, 小林正治, 大峡淳, 前田健康, 前田健康

    新潟歯学会雑誌   45 ( 2 )   106 - 106   2015.12

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 口腔粘膜上皮前駆/幹細胞を応用した培養複合口腔粘膜の皮下移植モデルにおける形態学的検討

    芳澤 享子, 小山 貴寛, 三上 俊彦, 船山 昭典, 齋藤 直朗, 小島 拓, 新美 奏恵, 小林 正治

    日本再生歯科医学会誌   13 ( 1 )   53 - 53   2015.12

    　More details

    Language：Japanese   Publisher：日本再生歯科医学会  

    researchmap

  • 下顎骨区域切除後に血管柄無し遊離腸骨移植により下顎骨再建を行った症例の臨床的検討

    小島 拓, 芳澤 享子, 金丸 祥平, 齋藤 直朗, 荒井 良明, 小林 正治

    Japanese Journal of Maxillo Facial Implants   14 ( 3 )   238 - 238   2015.11

    　More details

    Language：Japanese   Publisher：(公社)日本顎顔面インプラント学会  

    researchmap

  • バイオマテリアルと間葉系幹細胞による顎骨再生を目指した三次元的骨再生法の開発―その骨質と機能の評価―

    小島拓, 芳澤享子, 小野由起子, 坂上直子, 齋藤直朗, 長谷川智香, 網塚憲生, 前田健康, 小林正治

    日本歯科医学会誌   34   105   2015.3

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 3次元口腔粘膜培養モデルを用いたC配糖体が上皮形態形成に及ぼす効果の検証

    上野山敦士, 上野山敦士, 齋藤直朗, 原夕子, 原夕子, 齋藤太郎, 大貫尚志, 高木律男

    日本口腔科学会雑誌   64 ( 2 )   125 - 125   2015

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    J-GLOBAL

    researchmap

  • C配糖体が口腔粘膜上皮角化細胞と線維芽細胞から成る3次元口腔粘膜モデルに及ぼす影響の検討

    上野山敦士, 泉健次, 塩見晶, 齋藤直朗, 原夕子, 齋藤太郎, 大貫尚志, 加藤寛子, 安島久雄, 高木律男, 前田健康

    新潟歯学会雑誌   44 ( 2 )   127 - 127   2014.12

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 遊離腸骨移植後の再建下顎骨に対し歯科インプラントによる咬合再建を行った1例

    齋藤 直朗, 小島 拓, 加藤 祐介, 長谷部 大地, 須田 大亮, 荒井 良明, 小林 正治

    Japanese Journal of Maxillo Facial Implants   13 ( 3 )   149 - 149   2014.11

    　More details

    Language：Japanese   Publisher：(公社)日本顎顔面インプラント学会  

    researchmap

  • 骨髄細胞・多孔性β-TCPブロック複合体の骨形成過程における培養骨芽細胞様細胞の動態

    小野 由起子, 芳澤 享子, 齋藤 直朗, 小島 拓, 坂上 直子, 三上 俊彦, 船山 昭典, 小林 正治

    日本口腔科学会雑誌   63 ( 4 )   392 - 392   2014.9

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 骨細胞特異的死滅マウスの骨小腔基質溶解における微細構造学的検索

    齋藤 直朗, 李 敏啓, 辰巳 佐和子, 池田 恭治, 網塚 憲生, 小林 正治

    日本骨形態計測学会雑誌   24 ( 2 )   S100 - S100   2014.5

    　More details

    Language：Japanese   Publisher：日本骨形態計測学会  

    J-GLOBAL

    researchmap

  • 骨髄細胞・β-TCPブロック複合体における骨再生機序と骨質の組織学的解析

    小島 拓, 芳澤 享子, 小野 由起子, 坂上 直子, 齋藤 直朗, 小林 正治

    Clinical Calcium   24 ( 4 )   609 - 609   2014.3

    　More details

    Language：Japanese   Publisher：(株)医薬ジャーナル社  

    researchmap

  • C配糖体が培養口腔粘膜上皮角化細胞に及ぼす影響の検討

    上野山敦士, 泉健次, 塩見晶, 齋藤直朗, 齋藤太郎, 大貫尚志, 加藤寛子, 寺田(中石)典子, 河野芳朗, 野澤(井上, 佳世子, 高木律男, 前田健康

    再生医療   13   234   2014.1

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 多孔性ハイドロキシアパタイト骨補填材を用いた骨再生の組織学的解析

    齋藤 直朗, 小島 拓, 坂上 直子, 芳澤 享子, 小林 正治, 齊藤 力

    日本口腔科学会雑誌   63 ( 1 )   180 - 181   2014.1

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 骨髄細胞・多孔性β-TCPブロック複合体の骨形成過程に関する組織化学的検討

    小野 由起子, 芳澤 享子, 小島 拓, 齋藤 直朗, 坂上 直子, 三上 俊彦, 船山 昭典, 齊藤 力

    日本口腔科学会雑誌   63 ( 1 )   99 - 99   2014.1

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 反復加圧刺激が口腔粘膜上皮に及ぼす影響について3次元口腔粘膜モデルを用いた組織学的,免疫組織化学的検討

    塩見晶, 泉建次, 上野山敦士, 齋藤直朗, 齋藤太郎, 大貫尚志, 加藤寛子, 寺田(中石)典子, 河野芳朗, 野澤(井上, 佳世子, 野村修一, 前田健康

    新潟歯学会雑誌   43 ( 2 )   156 - 156   2013.12

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 新潟大学医歯学総合病院口腔再建外科における2012年の外来受診患者・入院患者に関する検討

    齋藤 直朗, 倉部 華奈, 小田 陽平, 芳澤 享子, 小林 正治, 鈴木 一郎, 新垣 晋, 齊藤 力

    新潟歯学会雑誌   43 ( 1 )   77 - 77   2013.6

    　More details

    Language：Japanese   Publisher：新潟歯学会  

    researchmap

  • 摘出により構音障害、睡眠時無呼吸の著明な改善が認められた巨大な舌下型類表皮嚢胞の1例

    安樂 純子, 大西 眞, 齋藤 直朗, 飯田 明彦, 櫻井 克也, 田辺 啓太

    日本形成外科学会会誌   33 ( 2 )   146 - 146   2013.2

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 多血小板血漿が抜歯後の治癒に及ぼす影響に関する検討

    新美 奏恵, 芳澤 享子, 小山 貴寛, 三上 俊彦, 小島 拓, 船山 昭典, 齋藤 直朗, 小野 由起子, 齊藤 力

    日本再生歯科医学会誌   10 ( 1 )   62 - 62   2012.12

    　More details

    Language：Japanese   Publisher：日本再生歯科医学会  

    researchmap

  • c-fos遺伝子欠損マウスにおける骨細胞の組織化学的解析

    佐々木 理絵, 李 敏啓, 齋藤 直朗, Freitas Paulo, 織田 公光, 網塚 憲生

    解剖学雑誌   85 ( Suppl. )   201 - 201   2010.3

    　More details

    Language：Japanese   Publisher：(一社)日本解剖学会  

    researchmap

  • OVXラットの柵状織においてED-71は骨微小モデリングを促進し、破骨細胞数を減少させる(ED-71 drives bone minimodeling and reduces osteoclastic number in trabeculae of OVX rats)

    Henrique Luiz de, Freitas Paulo, 李 敏啓, 齋藤 直朗, 高木 律男, 網塚 憲生

    日本骨形態計測学会雑誌   18 ( 2 )   S90 - S90   2008.7

    　More details

    Language：English   Publisher：日本骨形態計測学会  

    researchmap

  • 骨細胞特異的死滅マウスの骨小腔・骨細管系における微細構造学的検索

    齋藤 直朗, 李 敏啓, 辰巳 佐和子, 池田 恭治, 網塚 憲生

    解剖学雑誌   83 ( Suppl. )   160 - 160   2008.3

    　More details

    Language：Japanese   Publisher：(一社)日本解剖学会  

    J-GLOBAL

    researchmap

  • 骨質の評価 ステロイド性骨粗鬆症における骨質

    LI Minq, 齋藤直朗, 網塚憲生

    Clin Calcium   18 ( 3 )   328 - 335   2008.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 骨形成・骨吸収の最近のトピックス V 骨形成のトピックス 5.骨形態からみた骨形成調節機構―前骨芽細胞の形態と骨形成に対する役割―

    網塚憲生, FREITAS Paulo H L, UBAIDUS Sobhan, 齋藤直朗, LI Minqi

    Bone   21 ( 6 )   723-729,690-691 - 729   2007.11

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

▶ display all

Presentations

▶ display all

Awards

  • The 58th Congress of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons Excellence Poster Award

    2019.11   Korean Association of Maxillofacial Plastic and Reconstructive Surgeons   Assessment of risk factors for progressive condylar resorption after mandibular advancement.

    　More details

  • 第34回日本骨形態計測学会 若手研究者賞

    2014.6   日本骨形態計測学会  

    齋藤直朗

    　More details

Research Projects

  • 薬剤関連顎骨壊死のメカニズムを大局的に解明するー骨細胞ネットワークに着目してー

    2019.4 - 2024.3

    System name：若手研究

    Awarding organization：日本学術振興会

    齋藤直朗

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

  • 良好な骨質を有する骨再生の獲得 －骨細胞の重要性－

    2015.4 - 2016.3

    System name：特別研究員奨励費

    Awarding organization：日本学術振興会

    齋藤直朗, 日本学術振興会特別研究員

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

 

Teaching Experience

  • 口腔外科学I

    2026
    Institution name：新潟大学

  • 歯科診療補助II

    2026
    Institution name：新潟大学

  • 口腔外科学II

    2026
    Institution name：新潟大学

  • 臨床実習II

    2022
    Institution name：新潟大学

  • 臨床実習I

    2022
    Institution name：新潟大学

  • 臨床予備実習

    2021
    Institution name：新潟大学

  • 口腔と全身との関わり

    2020
    Institution name：新潟大学

▶ display all