Updated on 2022/12/01

写真a

 
HOKARI Satoshi
 
Organization
University Medical and Dental Hospital Respiratory Medicine and Infectious Disease Specially Appointed Assistant Professor
Title
Specially Appointed Assistant Professor
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Degree

  • 博士(医学) ( 2015.3   新潟大学 )

Research Interests

  • 呼吸器内科学

  • Tumor Biology

  • Respiratory Care

  • Sleep related breathing disorders

  • ChIP-seq

  • NPPV

  • 次世代シーケンサー

  • 呼吸リハビリテーション

  • 睡眠時無呼吸症候群

  • がんゲノム

  • Respiratory Medicine

  • TTF-1

Research Areas

  • Life Science / Medical management and medical sociology

  • Life Science / Genome biology

  • Life Science / Tumor biology

  • Life Science / Respiratory medicine

  • Life Science / Experimental pathology

Research History (researchmap)

  • Niigata University   Respiratory Medicine and Infectious Disease, Medical and Dental Hospital   Specially Appointed Assistant Professor

    2019.4

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  • The University of Tokyo, Graduate School of Medicine   Miyazono-Laboratoy, Department of Molecular Pathology

    2017.4 - 2019.3

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    Country:Japan

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  • Niigata University   Graduate School of Medical and Dental Sciences

    2016.7 - 2019.3

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  • The University of Tokyo, Graduate School of Medicine   Miyazono-Laboratoy, Department of Molecular Pathology   Guest Researcher

    2016.7 - 2017.3

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    Country:Japan

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  • Niigata University   Respiratory Medicine and Infectious Disease, Medical and Dental Hospital

    2015.4 - 2016.6

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Research History

  • Niigata University   University Medical and Dental Hospital Respiratory Medicine and Infectious Disease   Specially Appointed Assistant Professor

    2019.4

Education

  • Niigata University   Graduate School of Medical and Dental Sciences   地域疾病制御

    2011.4 - 2015.3

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  • Niigata University   Faculty of Medicine   School of Medicine

    2000.4 - 2006.3

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Professional Memberships

  • American Association for Cancer Research (AACR)

    2020.2

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  • Japanese Cancer Association

    2020.2

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  • 日本呼吸療法医学会

    2019.4

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  • 日本呼吸ケア・リハビリテーション学会

    2014.10

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • THE JAPANESE SOCIETY OF SLEEP RESEARCH

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  • THE JAPANESE RESPIRATORY SOCIETY

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  • THE JAPANESE SOCIETY FOR TUBERCULOSIS

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Committee Memberships

  • 新潟大学医歯学総合病院 呼吸器・感染症内科   外来医長  

    2022.4   

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  • 新潟呼吸療法研究会   幹事  

    2020   

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    Committee type:Academic society

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  • 新潟睡眠呼吸障害研究会   幹事  

    2020   

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    Committee type:Academic society

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  • 新潟呼吸ケアフォーラム   ボードメンバー  

    2020   

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    Committee type:Other

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  • 日本呼吸器学会・日本呼吸療法医学会・日本集中治療医学会   ARDS診療ガイドライン2021システマティックレビュー委員  

    2020   

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    Committee type:Academic society

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  • 新潟大学医歯学総合病院   リスクマネジャー  

    2022.4   

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  • 新潟大学   倫理審査委員会  

    2021   

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  • 新潟大学医学部医学科   カリキュラム委員  

    2021   

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Studying abroad experiences

  • 東京大学大学院 医学系研究科 分子病理学分野   特任研究員

    2016.4 - 2019.3

Qualification acquired

  • 日本呼吸器学会呼吸器専門医

  • 日本内科学会総合内科専門医

  • Board Certified Physician of the Japanese Society of Sleep Research

  • 呼吸ケア指導士(初級)

 

Papers

  • ARDS clinical practice guideline 2021

    Sadatomo Tasaka, Shinichiro Ohshimo, Muneyuki Takeuchi, Hideto Yasuda, Kazuya Ichikado, Kenji Tsushima, Moritoki Egi, Satoru Hashimoto, Nobuaki Shime, Osamu Saito, Shotaro Matsumoto, Eishu Nango, Yohei Okada, Kenichiro Hayashi, Masaaki Sakuraya, Mikio Nakajima, Satoshi Okamori, Shinya Miura, Tatsuma Fukuda, Tadashi Ishihara, Tetsuro Kamo, Tomoaki Yatabe, Yasuhiro Norisue, Yoshitaka Aoki, Yusuke Iizuka, Yutaka Kondo, Chihiro Narita, Daisuke Kawakami, Hiromu Okano, Jun Takeshita, Keisuke Anan, Satoru Robert Okazaki, Shunsuke Taito, Takuya Hayashi, Takuya Mayumi, Takero Terayama, Yoshifumi Kubota, Yoshinobu Abe, Yudai Iwasaki, Yuki Kishihara, Jun Kataoka, Tetsuro Nishimura, Hiroshi Yonekura, Koichi Ando, Takuo Yoshida, Tomoyuki Masuyama, Masamitsu Sanui, Takuro Nakashima, Aiko Masunaga, Aiko Tanaka, Akihiko Inoue, Akiko Higashi, Atsushi Tanikawa, Atsushi Ujiro, Chihiro Takayama, Daisuke Kasugai, Daisuke Kawakami, Daisuke Ueno, Daizoh Satoh, Shinichi Kai, Kohei Ota, Yoshihiro Hagiwara, Jun Hamaguchi, Ryo Fujii, Takashi Hongo, Yuki Kishihara, Naohisa Masunaga, Ryohei Yamamoto, Satoru Robert Okazaki, Ryo Uchimido, Tetsuro Terayama, Satoshi Hokari, Hitoshi Sakamoto, Dongli, Emiko Nakataki, Erina Tabata, Seisuke Okazawa, Futoshi Kotajima, Go Ishimaru, Haruhiko Hoshino, Hideki Yoshida, Hidetaka Iwai, Hiroaki Nakagawa, Hiroko Sugimura, Hiromichi Narumiya, Hiromu Okano, Hiroshi Nakamura, Hiroshi Sugimoto, Hiroyuki Hashimoto, Hiroyuki Ito, Hisashi Dote, Hisashi Imahase, Hitoshi Sato, Masahiro Katsurada, Ichiro Osawa, Jun Kamei, Jun Maki, Jun Sugihara, Jun Takeshita, Junichi Fujimoto, Junichi Ishikawa, Junko Kosaka, Junpei Shibata, Katsuhiko Hashimoto, Yasushi Nakano, Kazuki Kikuyama, Kazushige Shimizu, Kazuya Okada, Keishi Kawano, Keisuke Anan, Keisuke Ota, Ken-ichi Kano, Kengo Asano, Kenichi Hondo, Kenji Ishii, Kensuke Fujita, Kenta Ogawa, Kentaro Ito, Kentaro Tokunaga, Kenzo Ishii, Kohei Kusumoto, Kohei Takimoto, Kohei Yamada, Koichi Naito, Koichi Yamashita, Koichi Yoshinaga, Kota Yamauchi, Maki Murata, Makiko Konda, Manabu Hamamoto, Masaharu Aga, Masahiro Kashiura, Masami Ishikawa, Masayuki Ozaki, Michihiko Kono, Michihito Kyo, Minoru Hayashi, Mitsuhiro Abe, Mitsunori Sato, Mizu Sakai, Motoshi Kainuma, Naoki Tominaga, Naoya Iguchi, Natsuki Nakagawa, Nobumasa Aoki, Norihiro Nishioka, Norihisa Miyashita, Nozomu Seki, Ryo Ikebe, Ryosuke Imai, Ryota Tate, Ryuhei Sato, Sachiko Miyakawa, Satoshi Kazuma, Satoshi Nakano, Satoshi Tetsumoto, Satoshi Yoshimura, Shigenori Yoshitake, Shin-etsu Hoshi, Shingo Ohki, Shintaro Sato, Shodai Yoshihiro, Shoichi Ihara, Shota Yamamoto, Shunichi Koide, Shunsuke Kimata, Shunsuke Saito, Shunsuke Yasuo, Shusuke Sekine, Soichiro Mimuro, Soichiro Wada, Sosuke Sugimura, Tadashi Ishihara, Tadashi Kaneko, Tadashi Nagato, Takaaki Maruhashi, Takahiro Tamura, Takanori Ohno, Takashi Ichiyama, Takashi Niwa, Takashi Ueji, Takayuki Ogura, Takeshi Kawasaki, Takeshi Tanaka, Takeshi Umegaki, Taku Furukawa, Taku Omura, Takumi Nagao, Takuya Mayumi, Takuya Taniguchi, Takuya Yoshida, Tatsutoshi Shimatani, Teppei Murata, Tetsuya Sato, Tohru Sawamoto, Yoshifumi Koukei, Tomohiro Takehara, Tomomi Ueda, Tomoya Katsuta, Tomoya Nishino, Toshiki Yokoyama, Ushio Higashijima, Wataru Iwanaga, Yasushi Inoue, Yoshiaki Iwashita, Yoshie Yamada, Yoshifumi Kubota, Yoshihiro Suido, Yoshihiro Tomioka, Yoshihisa Fujimoto, Yoshihito Fujita, Yoshikazu Yamaguchi, Yoshimi Nakamura, Yoshinobu Abe, Yoshitomo Eguchi, Yoshiyasu Oshima, Yosuke Fukuda, Yudai Iwasaki, Yuichi Yasufuku, Yuji Shono, Yuka Nakatani, Yuki Nakamori, Yukie Ito, Yuko Tanabe, Yusuke Nagamine, Yuta Nakamura, Yutaro Kurihara

    Respiratory Investigation   2022.6

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.resinv.2022.05.003

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  • Respiratory support strategy in adults with acute hypoxemic respiratory failure: a systematic review and network meta-analysis. Reviewed International journal

    Hiromu Okano, Masaaki Sakuraya, Tomoyuki Masuyama, Shunsuke Kimata, Satoshi Hokari

    JA clinical reports   8 ( 1 )   34 - 34   2022.5

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    INTRODUCTION: Network meta-analyses (NMAs) of respiratory management strategies for acute hypoxemic respiratory failure (AHRF) have been reported, but no previous study has compared noninvasive ventilation (NIV), high-flow nasal oxygen (HFNO), standard oxygenation therapy (SOT), and invasive mechanical ventilation (IMV) for de novo AHRF. Therefore, we conducted an NMA to assess the effectiveness of these four respiratory strategies in patients with de novo AHRF. METHODS: The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Ichushi databases were searched. Studies including adults aged ≥18 years with AHRF and RCTs that compared two different oxygenation techniques (SOT, NIV, HFNO, or IMV) were selected. A frequentist-based approach with multivariate random-effects meta-analysis was used. The outcomes were mortality and intubation rates. RESULTS: Among the 14,263 records initially identified, 25 studies (3302 patients) were included. In the analysis of mortality, compared to SOT, NIV (risk ratio [RR], 0.76; 95% confidence interval [CI], 0.61-0.95) reduced mortality; however, IMV (RR, 1.01; 95% CI, 0.57-1.78) and HFNO (RR, 0.89; 95% CI, 0.66-1.20) did not. For assessments of the intubation incidence, compared to SOT, NIV use (RR, 0.63; 95% CI, 0.51-0.79) was associated with a reduction in intubation, but HFNO (RR, 0.82; 95% CI, 0.61-1.11) was not significant. CONCLUSIONS: Our NMA demonstrated that only NIV showed clinical benefits compared with SOT as an initial respiratory strategy for de novo AHRF. Further investigation, especially comparison with HFNO, is warranted. TRIAL REGISTRATION: PROSPERO (registration number: CRD42020213948 , 11/11/2020).

    DOI: 10.1186/s40981-022-00525-4

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  • Prognostic significance of procalcitonin in small cell lung cancer Reviewed International journal

    Kosuke Ichikawa, Satoshi Watanabe, Satoru Miura, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Tomohiro Tanaka, Yu Saida, Rie Kondo, Satoshi Hokari, Nobumasa Aoki, Yasuyoshi Ohshima, Toshiyuki Koya, Toshiaki Kikuchi

    Translational Lung Cancer Research   11 ( 1 )   43 - 52   2022.1

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    BACKGROUND: Procalcitonin (PCT) is a serological marker whose utility has been established in infectious disease areas. Although serum calcitonin is a prognostic predictor in patients with medullary thyroid carcinoma, the clinical usefulness of PCT remains unclear in lung cancer patients. METHODS: As a discovery cohort, we retrospectively analyzed consecutive patients with non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) who received first-line chemotherapy at our institution, and PCT blood levels were measured. As the validation cohort, PCT blood levels were prospectively evaluated in SCLC patients before first-line chemotherapy. The correlation between a PCT increase and prognosis was examined in the discovery and validation cohorts. RESULTS: Twenty-three SCLC patients and 26 NSCLC patients were enrolled as the discovery cohort, and 30 SCLC patients were enrolled as the validation cohort. The PCT level in SCLC patients was significantly higher than that in NSCLC patients. The PCT level was not associated with WBC count and weakly associated with the CRP level. In both the discovery and validation cohorts, the median survival time was significantly shorter in SCLC patients with PCT-high than in SCLC patients with PCT-normal (discovery; 11.7 vs. 89.7 months, P<0.005, validation; 9.6 vs. 22.6 months, P<0.005). CONCLUSIONS: It may be difficult to differentiate bacterial infections in SCLC patients by PCT, as PCT is elevated even in SCLC patients without infectious diseases. This is the first study to prospectively verify that pretreatment PCT levels have a significant negative correlation with prognosis in SCLC patients.

    DOI: 10.21037/tlcr-21-838

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  • Optogenetic activation of DRN 5-HT neurons induced active wakefulness, not quiet wakefulness Reviewed International journal

    Rika Moriya, Mitsuko Kanamaru, Naoki Okuma, Akira Yoshikawa, Kenji F. Tanaka, Satoshi Hokari, Yasuyoshi Ohshima, Akihiro Yamanaka, Motoyasu Honma, Hiroshi Onimaru, Toshiaki Kikuchi, Masahiko Izumizaki

    Brain Research Bulletin   177   129 - 142   2021.12

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    There has been a long-standing controversy regarding the physiological role of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) in sleep/wake architecture. Some studies have reported that 5-HT acts as a sleep-promoting agent, but several studies have suggested that DRN 5-HT neurons function predominantly to promote wakefulness and inhibit rapid eye movement (REM) sleep. Furthermore, recent studies have reported that there is a clear neurobiological difference between a waking state that includes alertness and active exploration (i.e., active wakefulness) and a waking state that is devoid of locomotion (i.e., quiet wakefulness). These states have also been shown to differ clinically in terms of memory consolidation. However, the effects of 5-HT neurons on the regulation of these two different waking states have not been fully elucidated. In the present study, we attempted to examine the physiological role of DRN 5-HT neurons in various sleep/wake states using optogenetic methods that allowed manipulation of cell-type specific neuronal activation with high temporal and anatomical precision. We crossed TPH2-tTA and TetO-ChR2(C128S) mice to obtain mice with channelrhodopsin-2 (ChR2) [C128S]-expressing central 5-HT neurons, and we activated DRN-5HT neurons or medullary 5-HT neurons. Optogenetic activation of DRN 5-HT neurons caused rapid transition from non-REM sleep to active wakefulness, not quiet wakefulness, whereas activation of medullary 5-HT neurons did not appear to affect sleep/wake states or locomotor activity. Our results may shed light on the physiological role of DRN 5-HT neurons in sleep/wake architecture and encourage further investigations of the cortical functional connectivity involved in sleep/wake state regulation.

    DOI: 10.1016/j.brainresbull.2021.09.019

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  • Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxaemic respiratory failure: a systematic review and network meta-analysis Reviewed International journal

    Masaaki Sakuraya, Hiromu Okano, Tomoyuki Masuyama, Shunsuke Kimata, Satoshi Hokari

    Critical Care   25 ( 1 )   414 - 414   2021.12

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    <title>Abstract</title><sec>
    <title>Background</title>
    Although non-invasive respiratory management strategies have been implemented to avoid intubation, patients with de novo acute hypoxaemic respiratory failure (AHRF) are high risk of treatment failure. In the previous meta-analyses, the effect of non-invasive ventilation was not evaluated according to ventilation modes in those patients. Furthermore, no meta-analyses comparing non-invasive respiratory management strategies with invasive mechanical ventilation (IMV) have been reported. We performed a network meta-analysis to compare the efficacy of non-invasive ventilation according to ventilation modes with high-flow nasal oxygen (HFNO), standard oxygen therapy (SOT), and IMV in adult patients with AHRF.


    </sec><sec>
    <title>Methods</title>
    The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Ichushi databases were searched. Studies including adults with AHRF and randomized controlled trials (RCTs) comparing two different respiratory management strategies (continuous positive airway pressure (CPAP), pressure support ventilation (PSV), HFNO, SOT, or IMV) were reviewed.


    </sec><sec>
    <title>Results</title>
    We included 25 RCTs (3,302 participants: 27 comparisons). Using SOT as the reference, CPAP (risk ratio [RR] 0.55; 95% confidence interval [CI] 0.31–0.95; very low certainty) was associated significantly with a lower risk of mortality. Compared with SOT, PSV (RR 0.81; 95% CI 0.62–1.06; low certainty) and HFNO (RR 0.90; 95% CI 0.65–1.25; very low certainty) were not associated with a significantly lower risk of mortality. Compared with IMV, no non-invasive respiratory management was associated with a significantly lower risk of mortality, although all certainties of evidence were very low. The probability of being best in reducing short-term mortality among all possible interventions was higher for CPAP, followed by PSV and HFNO; IMV and SOT were tied for the worst (surface under the cumulative ranking curve value: 93.2, 65.0, 44.1, 23.9, and 23.9, respectively).


    </sec><sec>
    <title>Conclusions</title>
    When performing non-invasive ventilation among patients with de novo AHRF, it is important to avoid excessive tidal volume and lung injury. Although pressure support is needed for some of these patients, it should be applied with caution because this may lead to excessive tidal volume and lung injury.


    <italic>Trial registration</italic> protocols.io (Protocol integer ID 49375, April 23, 2021). <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" xlink:href="https://doi.org/10.17504/protocols.io.buf7ntrn">10.17504/protocols.io.buf7ntrn</ext-link>.


    </sec>

    DOI: 10.1186/s13054-021-03835-8

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    Other Link: https://link.springer.com/article/10.1186/s13054-021-03835-8/fulltext.html

  • The Prognostic Significance of the Continuous Administration of Anti-PD-1 Antibody via Continuation or Rechallenge After the Occurrence of Immune-Related Adverse Events. Reviewed International journal

    Toshiya Fujisaki, Satoshi Watanabe, Takeshi Ota, Kohei Kushiro, Yusuke Sato, Miho Takahashi, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Satoshi Hokari, Rie Kondo, Takao Miyabayashi, Tetsuya Abe, Satoru Miura, Hiroshi Tanaka, Masaaki Okajima, Masaki Terada, Naoya Matsumoto, Takashi Ishida, Akira Iwashima, Kazuhiro Sato, Hirohisa Yoshizawa, Nobumasa Aoki, Masachika Hayashi, Yasuyoshi Ohshima, Toshiyuki Koya, Toshiaki Kikuchi

    Frontiers in oncology   11   704475 - 704475   2021.9

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    <sec><title>Objectives</title>Although immune checkpoint inhibitors (ICIs) have been shown to improve overall survival (OS) in advanced non-small-cell lung cancer (NSCLC) patients, ICIs sometimes cause various types of immune-related adverse events (irAEs), which lead to the interruption of ICI treatment. This study aims to evaluate the clinical significance of the continuation of ICIs in NSCLC patients with irAEs and to assess the safety and efficacy of the readministration of ICIs after their discontinuation due to irAEs.

    </sec><sec><title>Methods</title>We retrospectively identified patients with advanced NSCLC who were treated with first- to third-line anti-programmed cell death-1 (PD-1) therapy from January 2016 through October 2017 at multiple institutions belonging to the Niigata Lung Cancer Treatment Group. Progression-free survival (PFS) and OS from the initiation of ICI treatment were analyzed in patients with and without irAEs, with and without ICI interruption, and with and without ICI readministration. A 6-week landmark analysis of PFS and OS was performed to minimize the lead-time bias associated with time-dependent factors.

    </sec><sec><title>Results</title>Of 231 patients who received anti-PD-1 antibodies, 93 patients (40%) developed irAEs. Of 84 eligible patients with irAEs, 32 patients (14%) continued ICIs, and OS was significantly longer in patients who continued ICIs than that in patients who discontinued ICIs [not reached (95% CI: NE-NE) <italic>vs</italic>. not reached (95% CI: 22.4–NE); p = 0.025]. Of 52 patients who discontinued ICIs, 14 patients (6.1%) readministered ICIs, and OS in patients with ICI readministration was significantly longer than that in patients without ICI readministration [not reached (95% CI: NE-NE) <italic>vs</italic>. not reached (95% CI: 8.4–NE); p = 0.031].

    </sec><sec><title>Conclusion</title>The current study demonstrated that both the continuation and readministration of ICIs after irAE occurrence improved OS compared to the permanent interruption of ICIs in NSCLC patients with ICI-related irAEs.

    </sec>

    DOI: 10.3389/fonc.2021.704475

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  • Subsequent systemic therapy for non-small cell lung cancer patients with immune checkpoint inhibitor-related interstitial lung disease. Reviewed International journal

    Yusuke Sato, Satoshi Watanabe, Takeshi Ota, Kohei Kushiro, Toshiya Fujisaki, Miho Takahashi, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Satoshi Hokari, Rie Kondo, Masachika Hayashi, Hiroyuki Ishikawa, Takao Miyabayashi, Tetsuya Abe, Satoru Miura, Hiroshi Tanaka, Masaaki Okajima, Masaki Terada, Takashi Ishida, Akira Iwashima, Kazuhiro Sato, Hirohisa Yoshizawa, Nobumasa Aoki, Yasuyoshi Ohshima, Toshiyuki Koya, Toshiaki Kikuchi

    Translational lung cancer research   10 ( 7 )   3132 - 3143   2021.7

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    Background: Although immune checkpoint inhibitors (ICIs) are effective for advanced non-small cell lung cancer (NSCLC), ICIs may cause interstitial lung disease (ILD), which results in treatment discontinuation and is sometimes fatal. Despite the high incidence of ICI-related ILD, there are few cancer treatment options for patients. This study aimed to evaluate the safety and efficacy of subsequent systemic cancer therapy in NSCLC patients with ICI-related ILD. Methods: We retrospectively assessed NSCLC patients who received programmed cell death-1 (PD-1) inhibitors as first- to third-line therapy at participating institutions of the Niigata Lung Cancer Treatment Group from January 2016 to October 2017. Results: This analysis included 231 patients, 32 (14%) of whom developed ICI-related ILD. Of these patients, 16 (7%) received subsequent systemic cancer treatments. The median overall survival (OS) tended to be longer in the systemic cancer therapy group than in the no systemic cancer therapy group [22.2 months (95% CI: 1-NE) vs. 4.5 months (95% CI: 1-NE); P=0.067]. ICI-related ILD recurred in half of the patients who received systemic cancer therapy, and the median OS tended to be shorter in patients with recurrent ICI-related ILD [22.0 months (95% CI: 1-NE) vs. 7.0 months (95% CI: 1-NE); P=0.3154]. Conclusions: According to the current study, systemic cancer treatment is effective in patients with ICI-related ILD; however, its safety is uncertain because of the high risk of ICI-related ILD recurrence and poor survival outcome following ILD recurrence.

    DOI: 10.21037/tlcr-21-198

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  • Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity. Reviewed International journal

    Masashi Arita, Satoshi Watanabe, Nobumasa Aoki, Shoji Kuwahara, Ryo Suzuki, Sawako Goto, Yuko Abe, Miho Takahashi, Miyuki Sato, Satoshi Hokari, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Rie Kondo, Masachika Hayashi, Yasuyoshi Ohshima, Hideyuki Kabasawa, Michihiro Hosojima, Toshiyuki Koya, Akihiko Saito, Toshiaki Kikuchi

    Scientific reports   11 ( 1 )   750 - 750   2021.1

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    Cisplatin, one of the most active anticancer agents, is widely used in standard chemotherapy for various cancers. Cisplatin is more poorly tolerated than other chemotherapeutic drugs, and the main dose-limiting toxicity of cisplatin is its nephrotoxicity, which is dose-dependent. Although less toxic methods of cisplatin administration have been established, cisplatin-induced nephrotoxicity remains an unsolved problem. Megalin is an endocytic receptor expressed at the apical membrane of proximal tubules. We previously demonstrated that nephrotoxic drugs, including cisplatin, are reabsorbed through megalin and cause proximal tubular cell injury. We further found that cilastatin blocked the binding of cisplatin to megalin in vitro. In this study, we investigated whether cilastatin could reduce cisplatin-induced nephrotoxicity without influencing the antitumor effects of cisplatin. Nephrotoxicity was decreased or absent in mice treated with cisplatin and cilastatin, as determined by kidney injury molecule-1 staining and the blood urea nitrogen content. Combined with cilastatin, a twofold dose of cisplatin was used to successfully treat the mice, which enhanced the antitumor effects of cisplatin but reduced its nephrotoxicity. These findings suggest that we can increase the dose of cisplatin when combined with cilastatin and improve the outcome of cancer patients.

    DOI: 10.1038/s41598-020-80853-6

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  • Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer. Reviewed International journal

    Satoshi Hokari, Yusuke Tamura, Atsushi Kaneda, Akihiro Katsura, Masato Morikawa, Fumihiko Murai, Shogo Ehata, Shuichi Tsutsumi, Yuichi Ishikawa, Hiroyuki Aburatani, Toshiaki Kikuchi, Kohei Miyazono, Daizo Koinuma

    Molecular oncology   14 ( 2 )   277 - 293   2020.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Thyroid transcription factor-1 (TTF-1, encoded by the NKX2-1 gene) is highly expressed in small-cell lung carcinoma (SCLC) and lung adenocarcinoma (LADC), but how its functional roles differ between SCLC and LADC remains to be elucidated. Here, we compared the genome-wide distributions of TTF-1 binding regions and the transcriptional programs regulated by TTF-1 between NCI-H209 (H209), a human SCLC cell line, and NCI-H441 (H441), a human LADC cell line, using chromatin immunoprecipitation-sequencing (ChIP-seq) and RNA-sequencing (RNA-seq). TTF-1 binding regions in H209 and H441 cells differed by 75.0% and E-box motifs were highly enriched exclusively in the TTF-1 binding regions of H209 cells. Transcriptome profiling revealed that TTF-1 is involved in neuroendocrine differentiation in H209 cells. We report that TTF-1 and achaete-scute homolog 1 (ASCL1, also known as ASH1, an E-box binding basic helix-loop-helix transcription factor, and a lineage-survival oncogene of SCLC) are coexpressed and bound to adjacent sites on target genes expressed in SCLC, and cooperatively regulate transcription. Furthermore, TTF-1 regulated expression of the Bcl-2 gene family and showed antiapoptotic function in SCLC. Our findings suggest that TTF-1 promotes SCLC growth and contributes to neuroendocrine and antiapoptotic gene expression by partly coordinating with ASCL1.

    DOI: 10.1002/1878-0261.12608

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  • Should pulmonologists be gatekeepers or supporters for preoperative patients? Invited Reviewed International journal

    Hokari S, Kikuchi T

    Respiratory investigation   58 ( 1 )   4 - 6   2020.1

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    Postoperative pulmonary complications (PPCs) are considered as a leading cause of poor surgical outcomes, and occur frequently even in non-cardiothoracic surgery. Several multifactorial risk indices show potential effectiveness in identification of patients at high risk of developing PPCs. In preoperative consultation from surgeons, pulmonologists often act as gatekeepers for indication of surgery. With regard to preventive strategy for PPCs, recent reports have suggested the usefulness of preoperative interventions, such as smoking cessation, inhalation therapy, medications, pulmonary rehabilitation, and sleep study followed by continuous positive airway pressure therapy. Now, pulmonologists have an important role as supporters for preoperative patient care.

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  • Breathing Irregularity Is Independently Associated With the Severity of Obstructive Sleep Apnea in Patients With Multiple System Atrophy. Reviewed International journal

    Nakayama H, Hokari S, Ohshima Y, Matsuto T, Shimohata T

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine   14 ( 10 )   1661 - 1667   2018.10

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    STUDY OBJECTIVES: Multiple system atrophy (MSA) is a neurodegenerative disease characterized by the combination of cerebellar ataxia, parkinsonism, and autonomic disturbance. Patients with MSA frequently have sleep-disordered breathing. In some patients with MSA, central sleep apnea manifests during the disease's natural course or as a treatment effect. Breathing instability may be involved in the development of obstructive sleep apnea (OSA); therefore, we investigated whether breathing instability affects the severity of OSA in patients with MSA. METHODS: Patients with MSA and a control group of individuals who were matched for age, body mass index (BMI), and supine apnea-hypopnea index (AHI) were recruited. Breathing instability was evaluated by using polysomnography to determine the irregular pattern with approximate entropy (ApEn) of chest respiratory movements during wakefulness before sleep onset. The ApEn values were compared between the groups. The severity of OSA was evaluated with background parameters and ApEn values by regression analysis. RESULTS: Twenty patients with MSA (9 men; mean age, 61 years; BMI, 24.1 kg/m2; supine AHI, 37.9 events/h) were compared to the control group. The ApEn values were higher in the patients with MSA than those in the control group (1.28 versus 1.11; P < .05). Multiple regression analysis showed that supine AHI was associated with ApEn values but not with BMI in patients with MSA and associated with BMI but not with ApEn values in the individuals in the control group. CONCLUSIONS: Patients with MSA had more breathing irregularity. In patients with MSA, breathing instability may be a more influential factor for OSA than BMI. COMMENTARY: A commentary on this article appears in this issue on page 1641.

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  • Long noncoding RNA NORAD regulates transforming growth factor-β signaling and epithelial-to-mesenchymal transition-like phenotype Reviewed

    Natsumi Kawasaki, Toshiki Miwa, Satoshi Hokari, Tsubasa Sakurai, Kazuho Ohmori, Kensuke Miyauchi, Kohei Miyazono, Daizo Koinuma

    Cancer Science   109 ( 7 )   2211 - 2220   2018.7

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    Long noncoding RNAs are involved in a variety of cellular functions. In particular, an increasing number of studies have revealed the functions of long noncoding RNA in various cancers
    however, their precise roles and mechanisms of action remain to be elucidated. NORAD, a cytoplasmic long noncoding RNA, is upregulated by irradiation and functions as a potential oncogenic factor by binding and inhibiting Pumilio proteins (PUM1/PUM2). Here, we show that NORAD upregulates transforming growth factor-β (TGF-β) signaling and regulates TGF-β-induced epithelial-to-mesenchymal transition (EMT)-like phenotype, which is a critical step in the progression of lung adenocarcinoma, A549 cells. However, PUM1 does not appear to be involved in this process. We thus focused on importin β1 as a binding partner of NORAD and found that knockdown of NORAD partially inhibits the physical interaction of importin β1 with Smad3, inhibiting the nuclear accumulation of Smad complexes in response to TGF-β. Our findings may provide a new mechanism underlying the function of NORAD in cancer cells.

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  • ZEB1-regulated inflammatory phenotype in breast cancer cells. Reviewed International journal

    Akihiro Katsura, Yusuke Tamura, Satoshi Hokari, Mayumi Harada, Masato Morikawa, Tsubasa Sakurai, Kei Takahashi, Anna Mizutani, Jun Nishida, Yuichiro Yokoyama, Yasuyuki Morishita, Takashi Murakami, Shogo Ehata, Kohei Miyazono, Daizo Koinuma

    Molecular oncology   11 ( 9 )   1241 - 1262   2017.9

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    Zinc finger E-box binding protein 1 (ZEB1) and ZEB2 induce epithelial-mesenchymal transition (EMT) and enhance cancer progression. However, the global view of transcriptional regulation by ZEB1 and ZEB2 is yet to be elucidated. Here, we identified a ZEB1-regulated inflammatory phenotype in breast cancer cells using chromatin immunoprecipitation sequencing and RNA sequencing, followed by gene set enrichment analysis (GSEA) of ZEB1-bound genes. Knockdown of ZEB1 and/or ZEB2 resulted in the downregulation of genes encoding inflammatory cytokines related to poor prognosis in patients with cancer, including IL6 and IL8, therefore suggesting that ZEB1 and ZEB2 have similar functions in terms of the regulation of production of inflammatory cytokines. Antibody array and ELISA experiments confirmed that ZEB1 controlled the production of the IL-6 and IL-8 proteins. The secretory proteins regulated by ZEB1 enhanced breast cancer cell proliferation and tumor growth. ZEB1 expression in breast cancer cells also affected the growth of fibroblasts in cell culture, and the accumulation of myeloid-derived suppressor cells in tumors in vivo. These findings provide insight into the role of ZEB1 in the progression of cancer, mediated by inflammatory cytokines, along with the initiation of EMT.

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  • Natural course and potential prognostic factors for sleep-disordered breathing in multiple system atrophy Reviewed

    Yasuyoshi Ohshima, Hideaki Nakayama, Naho Matsuyama, Satoshi Hokari, Takuro Sakagami, Tomoe Sato, Toshiyuki Koya, Tetsuya Takahashi, Toshiaki Kikuchi, Masatoyo Nishizawa, Takayoshi Shimohata

    SLEEP MEDICINE   34   13 - 17   2017.6

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    Objective/background: Multiple system atrophy (MSA) frequently results in the development of sleep disordered breathing (SDB). Few reports have described the natural course of this phenomenon. The aim of the present study was to determine the natural course of SDB and prognostic factors associated with such conditions in MSA.
    Patients/methods: Twenty-four consecutive patients were recruited with probable MSA, who had not been treated with continuous positive airway pressure (CPAP) and had undergone overnight poly-somnography (PSG) more than once following the development of snoring or stridor. Based on changes in the apnea-hypopnea index (AHI) over the course of the disease, patients were divided into two groups (AHI-maintained and AHI-deteriorated) and the clinical findings were compared.
    Results: Mean duration between the first and last PSG was 2.4 +/- 1.5 years, and patients underwent PSG assessment an average of 2.5 +/- 0.6 times during this period. During this interval, AHI increased from 19.4 +/- 22.8/hour to 34.4 +/- 30.1/hour (p = 0.006), although spontaneous improvement was observed in 29% of patients. Following the first PSG, all patients were diagnosed with obstructive sleep apnea; however, the SDB type changed from obstructive sleep apnea to central sleep apnea in 3 of the 24 (13%) patients during the period between the first and last PSG.
    Conclusions: Although SDB associated with MSA exacerbates with disease progression, spontaneous improvement in AHI may occur in some patients. Earlier development of snoring or stridor may predict rapid progression of SDB in MSA. (C) 2017 Elsevier B.V. All rights reserved.

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  • Superiority of respiratory failure risk index in prediction of postoperative pulmonary complications after digestive surgery in Japanese patients. Reviewed International journal

    Satoshi Hokari, Yasuyoshi Ohshima, Hideaki Nakayama, Ryoko Suzuki, Tomosue Kajiwara, Toshiyuki Koya, Hiroshi Kagamu, Toshinori Takada, Eiichi Suzuki, Ichiei Narita

    Respiratory investigation   53 ( 3 )   104 - 10   2015.5

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    BACKGROUND: Several multifactorial risk indexes have been proposed by Western countries for identifying patients at a high risk of developing postoperative pulmonary complications (PPC). However, there is no consensus on how to evaluate the risk of PPC and what multifactorial risk index should be adapted for Japanese patients. This study aimed at clarifying the utility of risk indexes to predict PPC following digestive surgeries in Japanese patients. METHODS: We retrospectively analyzed 892 patients who underwent digestive surgeries under general anesthesia in Niigata University Medical and Dental Hospital between January 2009 and March 2011. PPC was defined as postoperative respiratory failure and postoperative pneumonia. We calculated three risk indexes (respiratory failure risk index (RFRI), postoperative pneumonia risk index, and PPC risk score), and compared them between the PPC group and the non-PPC group. A receiver operating characteristic (ROC) curve analysis was employed to compare the usefulness of each index. RESULTS: PPC developed in 55 patients (6.2%). All risk indexes were significantly higher in the PPC group than the non-PPC group. The category classification of the risk scores demonstrated a significant tendency to increase the incidence rate of PPC. In the ROC analysis, the area under the curve for RFRI was 0.762 (95% CI 0.697-0.826), which was the highest value observed among these indexes. CONCLUSIONS: Multifactorial risk indexes are useful tools for identifying Japanese patients at a high risk of developing PPC following digestive surgeries. Of the risk indexes evaluated in this study, RFRI is potentially the most accurate in predicting PPC.

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  • ARDS Clinical Practice Guideline 2021

    Sadatomo Tasaka, Shinichiro Ohshimo, Muneyuki Takeuchi, Hideto Yasuda, Kazuya Ichikado, Kenji Tsushima, Moritoki Egi, Satoru Hashimoto, Nobuaki Shime, Osamu Saito, Shotaro Matsumoto, Eishu Nango, Yohei Okada, Kenichiro Hayashi, Masaaki Sakuraya, Mikio Nakajima, Satoshi Okamori, Shinya Miura, Tatsuma Fukuda, Tadashi Ishihara, Tetsuro Kamo, Tomoaki Yatabe, Yasuhiro Norisue, Yoshitaka Aoki, Yusuke Iizuka, Yutaka Kondo, Chihiro Narita, Daisuke Kawakami, Hiromu Okano, Jun Takeshita, Keisuke Anan, Satoru Robert Okazaki, Shunsuke Taito, Takuya Hayashi, Takuya Mayumi, Takero Terayama, Yoshifumi Kubota, Yoshinobu Abe, Yudai Iwasaki, Yuki Kishihara, Jun Kataoka, Tetsuro Nishimura, Hiroshi Yonekura, Koichi Ando, Takuo Yoshida, Tomoyuki Masuyama, Masamitsu Sanui, Takuro Nakashima, Aiko Masunaga, Aiko Tanaka, Akihiko Inoue, Akiko Higashi, Atsushi Tanikawa, Atsushi Ujiro, Chihiro Takayama, Daisuke Kasugai, Daisuke Kawakami, Daisuke Ueno, Daizoh Satoh, Shinichi Kai, Kohei Ota, Yoshihiro Hagiwara, Jun Hamaguchi, Ryo Fujii, Takashi Hongo, Yuki Kishihara, Naohisa Masunaga, Ryohei Yamamoto, Satoru Robert Okazaki, Ryo Uchimido, Tetsuro Terayama, Satoshi Hokari, Hitoshi Sakamoto, Dongli, Emiko Nakataki, Erina Tabata, Seisuke Okazawa, Futoshi Kotajima, Go Ishimaru, Haruhiko Hoshino, Hideki Yoshida, Hidetaka Iwai, Hiroaki Nakagawa, Hiroko Sugimura, Hiromichi Narumiya, Hiromu Okano, Hiroshi Nakamura, Hiroshi Sugimoto, Hiroyuki Hashimoto, Hiroyuki Ito, Hisashi Dote, Hisashi Imahase, Hitoshi Sato, Masahiro Katsurada, Ichiro Osawa, Jun Kamei, Jun Maki, Jun Sugihara, Jun Takeshita, Junichi Fujimoto, Junichi Ishikawa, Junko Kosaka, Junpei Shibata, Katsuhiko Hashimoto, Yasushi Nakano, Kazuki Kikuyama, Kazushige Shimizu, Kazuya Okada, Keishi Kawano, Keisuke Anan, Keisuke Ota, Ken-ichi Kano, Kengo Asano, Kenichi Hondo, Kenji Ishii, Kensuke Fujita, Kenta Ogawa, Kentaro Ito, Kentaro Tokunaga, Kenzo Ishii, Kohei Kusumoto, Kohei Takimoto, Kohei Yamada, Koichi Naito, Koichi Yamashita, Koichi Yoshinaga, Kota Yamauchi, Maki Murata, Makiko Konda, Manabu Hamamoto, Masaharu Aga, Masahiro Kashiura, Masami Ishikawa, Masayuki Ozaki, Michihiko Kono, Michihito Kyo, Minoru Hayashi, Mitsuhiro Abe, Mitsunori Sato, Mizu Sakai, Motoshi Kainuma, Naoki Tominaga, Naoya Iguchi, Natsuki Nakagawa, Nobumasa Aoki, Norihiro Nishioka, Norihisa Miyashita, Nozomu Seki, Ryo Ikebe, Ryosuke Imai, Ryota Tate, Ryuhei Sato, Sachiko Miyakawa, Satoshi Kazuma, Satoshi Nakano, Satoshi Tetsumoto, Satoshi Yoshimura, Shigenori Yoshitake, Shin-etsu Hoshi, Shingo Ohki, Shintaro Sato, Shodai Yoshihiro, Shoichi Ihara, Shota Yamamoto, Shunichi Koide, Shunsuke Kimata, Shunsuke Saito, Shunsuke Yasuo, Shusuke Sekine, Soichiro Mimuro, Soichiro Wada, Sosuke Sugimura, Tadashi Ishihara, Tadashi Kaneko, Tadashi Nagato, Takaaki Maruhashi, Takahiro Tamura, Takanori Ohno, Takashi Ichiyama, Takashi Niwa, Takashi Ueji, Takayuki Ogura, Takeshi Kawasaki, Takeshi Tanaka, Takeshi Umegaki, Taku Furukawa, Taku Omura, Takumi Nagao, Takuya Mayumi, Takuya Taniguchi, Takuya Yoshida, Tatsutoshi Shimatani, Teppei Murata, Tetsuya Sato, Tohru Sawamoto, Yoshifumi Koukei, Tomohiro Takehara, Tomomi Ueda, Tomoya Katsuta, Tomoya Nishino, Toshiki Yokoyama, Ushio Higashijima, Wataru Iwanaga, Yasushi Inoue, Yoshiaki Iwashita, Yoshie Yamada, Yoshifumi Kubota, Yoshihiro Suido, Yoshihiro Tomioka, Yoshihisa Fujimoto, Yoshihito Fujita, Yoshikazu Yamaguchi, Yoshimi Nakamura, Yoshinobu Abe, Yoshitomo Eguchi, Yoshiyasu Oshima, Yosuke Fukuda, Yudai Iwasaki, Yuichi Yasufuku, Yuji Shono, Yuka Nakatani, Yuki Nakamori, Yukie Ito, Yuko Tanabe, Yusuke Nagamine, Yuta Nakamura, Yutaro Kurihara

    Journal of Intensive Care   10 ( 1 )   446 - 495   2022.12

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    Abstract

    Background

    The joint committee of the Japanese Society of Intensive Care Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on ARDS Clinical Practice Guideline has created and released the ARDS Clinical Practice Guideline 2021.

    Methods

    The 2016 edition of the Clinical Practice Guideline covered clinical questions (CQs) that targeted only adults, but the present guideline includes 15 CQs for children in addition to 46 CQs for adults. As with the previous edition, we used a systematic review method with the Grading of Recommendations Assessment Development and Evaluation (GRADE) system as well as a degree of recommendation determination method. We also conducted systematic reviews that used meta-analyses of diagnostic accuracy and network meta-analyses as a new method.

    Results

    Recommendations for adult patients with ARDS are described: we suggest against using serum C-reactive protein and procalcitonin levels to identify bacterial pneumonia as the underlying disease (GRADE 2D); we recommend limiting tidal volume to 4–8 mL/kg for mechanical ventilation (GRADE 1D); we recommend against managements targeting an excessively low SpO<sub>2</sub> (PaO<sub>2</sub>) (GRADE 2D); we suggest against using transpulmonary pressure as a routine basis in positive end-expiratory pressure settings (GRADE 2B); we suggest implementing extracorporeal membrane oxygenation for those with severe ARDS (GRADE 2B); we suggest against using high-dose steroids (GRADE 2C); and we recommend using low-dose steroids (GRADE 1B). The recommendations for pediatric patients with ARDS are as follows: we suggest against using non-invasive respiratory support (non-invasive positive pressure ventilation/high-flow nasal cannula oxygen therapy) (GRADE 2D), we suggest placing pediatric patients with moderate ARDS in the prone position (GRADE 2D), we suggest against routinely implementing NO inhalation therapy (GRADE 2C), and we suggest against implementing daily sedation interruption for pediatric patients with respiratory failure (GRADE 2D).

    Conclusions

    This article is a translated summary of the full version of the ARDS Clinical Practice Guideline 2021 published in Japanese (URL: https://www.jsicm.org/publication/guideline.html). The original text, which was written for Japanese healthcare professionals, may include different perspectives from healthcare professionals of other countries.

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  • 気管支拡張症に合併し、動脈塞栓術で退縮が得られた気管支静脈瘤の1例

    倉科 健司, 穂苅 諭, 月岡 啓輔, 青木 信将, 木村 陽介, 林 正周, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    気管支学   43 ( 6 )   589 - 594   2021.11

  • PD-1 blockade therapy augments the antitumor effects of lymphodepletion and adoptive T cell transfer Reviewed International journal

    Miho Takahashi, Satoshi Watanabe, Ryo Suzuki, Masashi Arita, Ko Sato, Miyuki Sato, Yuki Sekiya, Yuko Abe, Toshiya Fujisaki, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Rie Kondo, Yu Saida, Satoshi Hokari, Nobumasa Aoki, Masachika Hayashi, Yasuyoshi Ohshima, Toshiyuki Koya, Toshiaki Kikuchi

    Cancer Immunology, Immunotherapy   2021.10

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    Lymphodepleting cytotoxic regimens enhance the antitumor effects of adoptively transferred effector and naïve T cells. Although the mechanisms of antitumor immunity augmentation by lymphodepletion have been intensively investigated, the effects of lymphodepletion followed by T cell transfer on immune checkpoints in the tumor microenvironment remain unclear. The current study demonstrated that the expression of immune checkpoint molecules on transferred donor CD4+ and CD8+ T cells was significantly decreased in lymphodepleted tumor-bearing mice. In contrast, lymphodepletion did not reduce immune checkpoint molecule levels on recipient CD4+ and CD8+ T cells. Administration of anti-PD-1 antibodies after lymphodepletion and adoptive transfer of T cells significantly inhibited tumor progression. Further analysis revealed that transfer of both donor CD4+ and CD8+ T cells was responsible for the antitumor effects of a combination therapy consisting of lymphodepletion, T cell transfer and anti-PD-1 treatment. Our findings indicate that a possible mechanism underlying the antitumor effects of lymphodepletion followed by T cell transfer is the prevention of donor T cell exhaustion and dysfunction. PD-1 blockade may reinvigorate exhausted recipient T cells and augment the antitumor effects of lymphodepletion and adoptive T cell transfer.

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  • Chronic Hypercapnic Respiratory Failure in an Adult Patient with Silver-Russell Syndrome. Reviewed

    Mariko Hakamata, Satoshi Hokari, Yasuyoshi Ohshima, Masayo Kagami, Sakae Saito, Ikuko N Motoike, Taiki Abe, Nobumasa Aoki, Masachika Hayashi, Satoshi Watanabe, Toshiyuki Koya, Toshiaki Kikuchi

    Internal medicine (Tokyo, Japan)   60 ( 12 )   1921 - 1926   2021.6

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    A 31-year-old woman who was clinically diagnosed with Silver-Russell syndrome (SRS) in childhood was admitted with complaints of dyspnea. She had hypercapnic respiratory failure accompanied by nocturnal hypoventilation. Computed tomography revealed systemic muscle atrophy and superior mesenteric artery syndrome; however, the bilateral lung fields were normal. She was treated with nocturnal noninvasive positive pressure ventilation and showed improvement of respiratory failure. In this case, loss of methylation on chromosome 11p15 and maternal uniparental disomy of chromosome 7, which are the common causes of SRS, were not detected. This is a rare case of adult SRS manifesting as chronic hypercapnic respiratory failure.

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  • Pneumonia Associated with Invasive and Noninvasive Oxygenation Strategies for Acute Hypoxemic Respiratory Failure in Adults: A Systematic Review and Network Meta-analysis Protocol v1

    Satoshi Hokari, Shunsuke Kimata, Masaaki Sakuraya, Hiromu Okano, Tomoyuki Masuyama

    protocols.io   2021.5

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    <p>Background: Noninvasive oxygenation strategies, such as noninvasive positive pressure ventilation and high-flow nasal cannula, have become common treatments for acute hypoxemic respiratory failure. However, further research is needed to understand the relative benefits and risks of each strategy. Aim: The purpose of this systematic review is to assess which noninvasive oxygenation strategy is best for reducing pneumonia in patients with acute hypoxemic respiratory failure. Methods and analysis: We will conduct a systematic review of the relevant literature according to the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. We will include randomized controlled trials assessing the effect of noninvasive oxygenation interventions for patients with acute hypoxemic respiratory failure. The main outcome is the incidence rate of pneumonia, which is not limited ventilator-associated pneumonia, aspiration pneumonia, and nosocomial pneumonia. Two independent reviewers will extract the data and assess the risk of bias. We will perform a meta-analysis using the GRADE Working Group Approach for a network meta-analysis. </p>

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  • A case of bronchiolitis obliterans after living-donor renal transplantation. Reviewed International journal

    Masachika Hayashi, Satoshi Hokari, Nobumasa Aoki, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Masayuki Tasaki, Kazuhide Saito, Toshiaki Kikuchi

    Respiratory investigation   59 ( 3 )   367 - 371   2021.5

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    We herein report the case of a 20 year-old-man who developed bronchiolitis obliterans after living-donor renal transplantation. The patient presented with dyspnea on exertion and wheezing two years after renal transplantation, and spirometry showed an obstructive pattern. Surgical lung biopsy revealed subepithelial fibrosis that constricted and obstructed the intrabronchiolar space. Based on these findings, the patient was diagnosed with bronchiolitis obliterans. He was prescribed bronchodilators and azithromycin, and he achieved stable respiratory function for two years. The differential diagnosis of respiratory symptoms after renal transplantation includes opportunistic infection and drug-induced lung injury; however, bronchiolitis obliterans should also be considered.

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  • ジアフェニルスルホンによる薬剤性メトヘモグロビン血症の3例

    穂苅 諭, 渡井 はづき[風間], 南雲 駿, 尾方 英至, 小泉 健, 市川 紘将, 青木 信将, 渡部 聡, 小屋 俊之, 菊地 利明

    日本内科学会雑誌   110 ( 3 )   622 - 626   2021.3

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  • A-DROP system for prognostication of NHCAP inpatients Reviewed

    Takeshi Koizumi, Hiroki Tsukada, Kazuhiko Ito, Satoshi Shibata, Satoshi Hokari, Takafumi Tetsuka, Nobumasa Aoki, Hiroshi Moro, Yoshinari Tanabe, Toshiaki Kikuchi

    JOURNAL OF INFECTION AND CHEMOTHERAPY   23 ( 8 )   523 - 530   2017.8

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    Nursing and healthcare-associated pneumonia (NHCAP) is a category of healthcare-associated pneumonia that was modified for the healthcare system of Japan. The NHCAP guidelines stated the difficulty in assessing the severity classifications, for instance, A-DROP. We compared the usefulness of different severity classifications (A-DROP, CURB-65, PSI, and I-ROAD) in predicting the prognosis of nursing and healthcare-associated pneumonia.
    We conducted a retrospective analysis on 303 adult patients hospitalized for nursing healthcare-associated pneumonia and community-acquired pneumonia, which were diagnosed at the Department of Respiratory Medicine of Niigata General City Hospital between January 2012 and December 2014.
    We evaluated 159 patients with community-acquired pneumonia and 144 with nursing and healthcare-associated pneumonia. In the nursing and healthcare-associated pneumonia group, 30-days mortality and in-hospital mortality rates were 6.5% and 8.7%, respectively, in severe cases and 16.1% and 25.0%, respectively, in the most severe cases, based on A-DROP. With I-ROAD, these rates were 11.1% and 11.1%, respectively, in group B and 14.9% and 20.7%, respectively, in group C. With PSI, the rates were 2.3% and 6.8%, respectively, in class IV and 14.3% and 19.8%, respectively, in class V. Despite some variability due to the small sample size, both the 30-days and in-hospital mortality rates increased as the severity increased.
    In this study, both the 30-days mortality and in-hospital mortality rates in the nursing and healthcare-associated pneumonia group tended to increase in severity with the A-DROP. We found that A-DROP was useful in predicting the prognosis of nursing and healthcare-associated pneumonia. (C) 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

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  • Non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans Reviewed

    Mari Orime, Katsuhiro Tomiyama, Hideki Hashidate, Satoru Yoshida, Satoshi Hokari, Akiko Tsuda, Hisashi Yokoyama, Jun-ichi Narita, Youhei Uchida, Takuro Kanekura, Riichiro Abe, Norito Ishii, Takashi Hashimoto, Kazuhiro Kawai

    JOURNAL OF DERMATOLOGY   44 ( 4 )   461 - 464   2017.4

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    Bronchiolitis obliterans is a small-airway obstructive lung disease for which immunologically mediated pathogenesis is supposed. Frequent association of bronchiolitis obliterans with paraneoplastic pemphigus is well known, but its association with other autoimmune bullous diseases has not been reported except for a case of anti-laminin-332-type mucous membrane pemphigoid in a patient with chronic graft-versus-host disease. We report a case of non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans in a patient without transplantation. Although the patient's serum contained immunoglobulin (Ig)A antibodies to the 180-kDa bullous pemphigoid antigen/type XVII collagen and IgG antibodies to laminin-332, diagnosis of either linear IgA bullous dermatosis or mucous membrane pemphigoid could not be made because of the failure to detect linear IgA deposition at the basement membrane zone by direct immunofluorescence and the lack of mucous membrane lesions. Physicians should be aware that autoimmune bullous diseases other than paraneoplastic pemphigus can also associate with this rare but potentially fatal lung disease.

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  • Histological Transformation to Large Cell Neuroendocrine Carcinoma from Lung Adenocarcinoma Harboring an EGFR Mutation: An Autopsy Case Report. Reviewed

    Rika Moriya, Satoshi Hokari, Satoshi Shibata, Takeshi Koizumi, Takafumi Tetsuka, Kazuhiko Ito, Hideki Hashidate, Hiroki Tsukada

    Internal medicine (Tokyo, Japan)   56 ( 15 )   2013 - 2017   2017

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    We herein report a 58-year-old Japanese woman who survived 14 years after surgery for lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) exon 19 deletion. She developed recurrence, for which she underwent multimodal therapy, including EGFR-tyrosine kinase inhibitor (TKI) administration. She ultimately died from a rapidly progressive right lung tumor that was resistant to EGFR-TKI. According to the autopsy findings, she had combined large-cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma in the right lung, which retained an EGFR exon 19 deletion in both components. Therefore, the histological transformation to LCNEC can be a mechanism of acquired EGFR-TKI resistance.

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  • A Case of Bilateral Phrenic Nerve Paralysis Secondary to Neuralgic Amyotrophy Associated with Obstructive Sleep Apnea Reviewed

    Satoshi Hokari, Yasuyoshi Ohshima, Ryoko Suzuki, Tomosue Kajiwara, Toshinori Takada, Eiichi Suzuki

    日本胸部臨床   75 ( 12 )   1420 - 1426   2016.12

  • ミコフェノール酸モフェチルを含む3剤併用療法を行った皮膚筋炎合併間質性肺疾患の1例 Reviewed

    島 賢治郎, 坂上 拓郎, 市川 紘将, 穂苅 諭, 朝川 勝明, 小屋 俊之, 各務 博, 高田 俊範, 成田 一衛

    日本呼吸器学会誌   4 ( 1 )   76 - 80   2015.1

  • 急性期II型呼吸不全に対する非侵襲的陽圧換気療法Average Volume Assured Pressure Support(AVAPS)モードの使用経験

    柴田 怜, 穂苅 諭, 小泉 健, 森谷 梨加, 手塚 貴文, 伊藤 和彦, 塚田 弘樹

    新潟市民病院医誌   34 ( 1 )   1 - 7   2013.9

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  • 新潟市民病院におけるIgG4関連疾患の診断についての検討

    小泉 健, 柴田 怜, 穂苅 諭, 木村 夕香, 張 仁美, 清水 崇, 手塚 貴文, 伊藤 和彦, 塚田 弘樹

    新潟市民病院医誌   33 ( 1 )   1 - 5   2012.9

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    【目的】当院におけるIgG4関連疾患の診断について、診療科による臨床的特徴などの検討を行った。【対象と方法】2010年9月から2011年12月までに、IgG4についてカルテに記載があった198症例を抽出し、そのうち、実際に血清IgG4が測定された161例を対象とし、臨床経過と診断過程をレトロスペクティブに検討した。【結果】血清IgG4を測定した患者は男性98名、女性63名で、年齢は平均63.7±15.1歳(17-86歳)であった。血清IgG4の中央値は41.1mg/dL(四分位範囲16.05-125.5mg/dL)、血清IgGの中央値は1504mg/dL(四分位範囲1238-2184mg/dL)であった。血清IgG4値を測定した診療科は、消化器内科(63例)、腎臓内科(40例)、呼吸器内科(17例)の順で、測定した理由としては、胆道狭窄・胆道系/膵腫瘍(34例)、膵炎(26例)、膠原病(18例)、頸部・顔面腫瘍(17例)、間質性肺炎・肺異常影(14例)の順であった。対象患者に認められた所見の中で、血清IgG4値が135mg/dL以上の患者の割合が多かった疾患は、自己免疫性膵炎(13例中10例、76.9%)、気管支喘息(4例中3例、75.0%)、唾液腺腫脹(12例中8例、66.7%)等であり、これらの所見はIgG4関連疾患の診断に有意な所見である可能性が示唆された。組織検体採取例は48例(29.8%)であり、免疫染色においてIgG4/IgG陽性細胞比が40%以上であった症例は9例であった。この9症例中、血清IgG4値が135mg/dL以上であった症例は2例のみであり、血清IgG4値と組織所見の間で乖離が見られた。【結論】新しい疾患概念であるIgG4関連疾患について、各科において診断に努めようとしていることが明らかになった。組織所見・血清所見・臨床所見には乖離が見られ、症例の蓄積によるさらに有用な診断基準の策定が待たれる。(著者抄録)

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  • 呼吸機能低下患者における術後呼吸器合併症リスク評価の検討 Reviewed

    穂苅 諭, 中山 秀章, 梶原 大季, 鈴木 涼子, 大嶋 康義, 高田 俊範, 鈴木 栄一, 成田 一衛

    日本呼吸ケア・リハビリテーション学会誌   21 ( 1 )   30 - 34   2011.6

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    DOI: 10.15032/jsrcr.21.1_30

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  • 維持血液透析療法に至った抗糸球体基底膜抗体型腎炎の1例

    穂苅 諭, 安宅 謙

    鶴岡市立荘内病院医学雑誌   20   7 - 10   2010.2

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    全身倦怠感、発熱を主訴とする76歳女性症例について検討した。尿素窒素(BUN)は34mg/dl、クレアチニン(Cre)は2.7mg/dlであった。発熱は遷延し、無尿となった。1週間後の血液検査では高度の炎症所見、腎機能障害等を認め、緊急持続血液濾過透析を開始した。その後、抗糸球体基底膜(GBM)抗体高力価陽性(>300EU)が判明した。血漿交換およびステロイドパルス療法を施行したところ、解熱、炎症反応の陰性化、抗GBM抗体の低下は得られたが、腎機能改善はみられず、維持血液透析に至った。以後ステロイド(PSL)を漸減していたが、PSL減量後も抗GBM抗体価は低下し、再燃はみられなかった。最終的には死亡したが、抗GBM抗体型腎炎は腎不全を呈した時点で予後不良であり、予後改善のためには早期発見・治療が重要だと考えられた。

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  • [Interstitial pneumonia associated with stiff-person syndrome].

    Satoshi Hokari, Toshiyuki Koya, Yuichi Shimaoka, Hideaki Nakayama, Masaki Terada, Eiichi Suzuki

    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society   48 ( 2 )   162 - 5   2010.2

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    A 68-year-old man who was given a diagnosis of interstitial pneumonia. Chest computerized tomography (CT) revealed subpleural honeycomb formations and traction bronchiectasis. Three months after the diagnosis of interstitial pneumonia, he noticed neurological symptoms, such as facial spasms, dysphagia, muscle rigidity and muscle cramp, and repeatedly received clonazepam. He was diagnosed with stiff-person syndrome on electromyography when he was hospitalized due to aspiration pneumonia. He has needed continuous rehabilitation due to the progression of neurological symptoms despite the partial efficacy of anti-epilepsy agents. We report a case of interstitial pneumonia with stiff-person syndrome.

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  • Stiff-person症候群に合併した間質性肺炎の1例 Reviewed

    穂苅 諭, 小屋 俊之, 島岡 雄一, 中山 秀章, 寺田 正樹, 鈴木 栄一

    日本呼吸器学会雑誌   48 ( 2 )   162 - 165   2010.2

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  • An autopsy case of disseminated cryptococcosis manifesting as acute diarrhea in a patient with primary biliary cirrhosis. Reviewed

    Satoshi Hokari, Hiroki Tsukada, Kazuhisa Ito, Hiroyuki Shibuya

    Internal medicine (Tokyo, Japan)   49 ( 16 )   1793 - 6   2010

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    A 58-year-old woman with an 18-year history of primary biliary cirrhosis was admitted because of pneumococcal pneumonia. She was treated with antibiotics and mechanical ventilation. After the pneumonia improved, she developed severe watery diarrhea. Although vancomycin was administered enterally, the diarrhea persisted. She died of multiple organ failure within 16 days of the onset of diarrhea. An autopsy showed intracapillary cryptococci in the systemic organs, especially in the intestinal tract. The cause of diarrhea was considered to be extensive intestinal mucosal necrosis due to disseminated cryptococcosis. This is a rare case of cryptococcal infection manifesting as acute diarrhea.

    DOI: 10.2169/internalmedicine.49.3785

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Books

  • 難治性びまん性肺疾患 診療の手引き

    穂苅 諭(協力者)

    日本呼吸器学会監修,南江堂  2017.10 

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  • チームで診る高齢者脆弱性骨折手術と周術期管理

    穂苅 諭( Role: Contributor ,  周術期における合併症とマネージメント)

    医薬ジャーナル社  2017.6 

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    Total pages:219   Responsible for pages:167-175  

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MISC

  • 慢性II型呼吸不全に潜在する抗ミトコンドリア抗体陽性患者に関する検討

    高橋 敦宣, 菊地 利明, 大嶋 康義, 穂苅 諭, 永井 明日香, 鈴木 涼子, 渡部 聡, 小屋 俊之, 島 賢治郎, 青木 信将

    日本呼吸器学会誌   11 ( 増刊 )   238 - 238   2022.4

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  • 当院におけるCPAPアドヒアランスに影響する因子の検討

    倉科 健司, 穂苅 諭, 永井 明日香, 鈴木 涼子, 大嶋 康義, 青木 信将, 林 正周, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   10 ( 増刊 )   298 - 298   2021.4

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  • 2型呼吸不全と抗ミトコンドリアM2抗体の関係性

    大嶋 康義, 倉科 健司, 穂苅 諭, 永井 明日香, 鈴木 涼子, 青木 信将, 林 正周, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸ケア・リハビリテーション学会誌   30 ( Suppl. )   197s - 197s   2021.2

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  • 閉塞性睡眠時無呼吸は尿細管障害のバイオマーカーである尿中NAGを増加させる

    森谷 梨加, 穂苅 諭, 藤戸 信宏, 鈴木 涼子, 大嶋 康義, 青木 信将, 林 正周, 渡部 聡, 小屋 俊之, 菊地 利明

    日本内科学会雑誌   109 ( Suppl. )   174 - 174   2020.2

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  • CPAPアドヒアランスと鼻腔通気度との関係

    藤戸 信宏, 穂苅 諭, 鈴木 涼子, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸ケア・リハビリテーション学会誌   29 ( Suppl. )   213s - 213s   2019.10

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  • 睡眠呼吸障害に対して、PAP療法の適応を探索する! 多系統萎縮症に対するPAP療法の探索

    大嶋 康義, 穂苅 諭, 渡部 聡, 小屋 俊之, 菊地 利明, 中山 秀章, 下畑 享良

    日本睡眠学会定期学術集会プログラム・抄録集   44回   159 - 159   2019.6

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  • 多系統萎縮症患者に合併した睡眠関連呼吸障害の経時的変化の検討

    大嶋 康義, 中山 秀章, 松山 菜穂, 穂苅 諭, 渡部 聡, 坂上 拓郎, 茂呂 寛, 小屋 俊之, 菊地 利明, 下畑 享良

    日本睡眠学会定期学術集会プログラム・抄録集   42回   180 - 180   2017.6

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  • 気管支静脈瘤による喀血を来した気管支拡張症の1例

    倉科 健司, 穂苅 諭, 月岡 啓輔, 青木 信将, 上野 浩志, 大坪 亜矢, 庄子 聡, 近藤 利恵, 林 正周, 大嶋 康義, 渡部 聡, 小屋 俊之, 菊地 利明, 池田 裕里恵, 山崎 元彦, 堀井 陽祐

    気管支学   42 ( 6 )   577 - 577   2020.11

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  • ニンテダニブはMDSCを抑制することでPD-1阻害剤の抗腫瘍効果を増強する

    鈴木 遼, 渡部 聡, 有田 将史, 関谷 友樹, 安部 悠子, 佐藤 美由紀, 高橋 美帆, 大坪 亜矢, 庄子 聡, 野嵜 幸一郎, 市川 紘将, 穂苅 諭, 近藤 利恵, 大嶋 康義, 小屋 俊之, 菊地 利明

    日本癌学会総会記事   79回   PJ12 - 9   2020.10

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  • シェーグレン症候群を有する非小細胞肺癌に対して免疫チェックポイント阻害薬を安全に使用できた一例

    大坪 亜矢, 久代 航平, 佐藤 佑輔, 高橋 美帆, 庄子 聡, 野嵜 幸一郎, 穂苅 諭, 市川 紘将, 近藤 利恵, 青木 信将, 大嶋 康義, 林 正周, 渡部 聡, 小屋 俊之, 菊地 利明

    肺癌   60 ( 6 )   724 - 724   2020.10

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  • ロングノンコーディングRNA NORADによるTGF-βシグナルおよび上皮間葉転換様形質の制御(lncRNA NORAD regulates transforming growth factor-β signaling and epithelial-to-mesenchymal transition-like phenotype)

    鯉沼 代造, 川崎 夏実, 穂苅 諭, 宮園 浩平

    日本癌学会総会記事   77回   1960 - 1960   2018.9

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  • 拡大するTGF-β/BMP制御のモダリティ 20355(イントロダクション含む)

    鯉沼 代造, 川崎 夏実, 三輪 俊貴, 穂苅 諭, 櫻井 翼, 大森 千穂, 宮内 建輔, 宮園 浩平

    日本生化学会大会プログラム・講演要旨集   91回   [2S09m - 01]   2018.9

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  • 当院における食道癌術後のPPC発生の実情

    韮澤 紀文, 大脇 教光, 藤戸 信宏, 穂苅 諭, 鈴木 涼子, 大嶋 康義, 上路 拓美, 木村 慎二

    日本呼吸ケア・リハビリテーション学会誌   27 ( Suppl. )   231s - 231s   2017.10

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  • 左上下葉気管支分岐部にポリープ状に発生した炎症性偽腫瘍の1例

    清水 勇希, 佐藤 征二郎, 後藤 達哉, 小池 輝元, 土田 正則, 林 正周, 穂苅 諭, 菊池 利明, 大橋 瑠子

    気管支学   39 ( 4 )   370 - 370   2017.7

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  • 背側縫線核セロトニン神経の睡眠・覚醒における役割(Activating dorsal raphe nucleus serotonin neurons affects control of vigilance state switch)

    Moriya Rika, Kanamaru Mitsuko, Okuma Naoki, Yoshikawa Akira, Tanaka Kenji F., Hokari Satoshi, Oshima Yasuyoshi, Onimaru Hiroshi, Izumizaki Masahiko

    The Journal of Physiological Sciences   67 ( Suppl.1 )   S165 - S165   2017.3

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  • 小腸転移による急性腹症を来したALK陽性肺癌の2例

    里方 真理子, 渡部 聡, 佐藤 美由紀, 穂苅 諭, 渡邊 伸, 林 正周, 近藤 利恵, 市川 紘将, 阿部 徹哉, 小屋 俊之, 菊地 利明, 小山 建一, 田中 洋史

    肺癌   56 ( 6 )   858 - 858   2016.11

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  • 鼻腔通気度の左右差がCPAPの使用に与える影響

    大嶋 康義, 穂苅 諭, 鈴木 涼子, 坂上 拓郎, 小屋 俊之, 菊地 利明

    日本睡眠学会定期学術集会プログラム・抄録集   41回   270 - 270   2016.7

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  • 気管支温熱療法を施行した重症気管支喘息の1例

    林 正周, 渡邊 伸, 佐藤 美由紀, 穂苅 諭, 近藤 利恵, 渡部 聡, 青木 信将, 大嶋 康義, 坂上 拓郎, 阿部 徹哉, 茂呂 寛, 小屋 俊之, 菊地 利明

    気管支学   38 ( 4 )   347 - 347   2016.7

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  • 当院における胸水貯留例に対する局所麻酔下胸腔鏡検査の有用性と安全性の検討

    吉澤 和孝, 近藤 利恵, 佐藤 美由紀, 上野 浩志, 穂苅 諭, 朝川 勝明, 林 正周, 青木 信将, 岡島 正明, 大嶋 康義, 渡邊 伸, 渡部 聡, 坂上 拓郎, 阿部 徹哉, 茂呂 寛, 小屋 俊之, 田中 純太, 森山 寛史, 菊地 利明, 田島 俊児

    気管支学   38 ( Suppl. )   S271 - S271   2016.5

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  • 気管支鏡施行時の大量出血により気道確保を要した症例の検討

    近藤 利恵, 佐藤 美由紀, 吉澤 和孝, 上野 浩志, 穂苅 諭, 朝川 勝明, 林 正周, 青木 信将, 岡島 正明, 大嶋 康義, 渡邊 伸, 渡部 聡, 坂上 拓郎, 阿部 徹哉, 茂呂 寛, 小屋 俊之, 森山 寛史, 菊地 利明

    気管支学   38 ( Suppl. )   S256 - S256   2016.5

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  • 当院におけるEBUS-TBNAによるサルコイドーシス診断の後方視的検討

    林 正周, 上野 浩志, 吉澤 和孝, 佐藤 美由紀, 穂苅 諭, 青木 信将, 朝川 勝明, 大嶋 康義, 岡島 正明, 近藤 利恵, 渡邊 伸, 渡部 聡, 坂上 拓郎, 阿部 徹哉, 茂呂 寛, 小屋 俊之, 田中 純太, 森山 寛史, 菊地 利明, 田島 俊児

    気管支学   38 ( Suppl. )   S197 - S197   2016.5

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  • 新潟市民病院呼吸器内科における肺炎症例の検討 NHCAPにおける重症度分類の有効性について

    小泉 健, 柴田 怜, 森谷 梨加, 穂苅 諭, 手塚 貴文, 伊藤 和彦, 塚田 弘樹

    新潟医学会雑誌   129 ( 11 )   701 - 701   2015.11

  • 肺移植後長期経過ののち呼吸不全が進行した症例への呼吸リハの経験

    堀井 麻美子, 韮澤 紀文, 穂苅 諭, 鈴木 涼子, 大嶋 康義, 張替 徹, 木村 慎二, 上路 拓美

    日本呼吸ケア・リハビリテーション学会誌   25 ( Suppl. )   246s - 246s   2015.9

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  • 周術期呼吸リハビリテーションによるPPCへの効果

    韮澤 紀文, 堀井 麻美子, 穂苅 諭, 鈴木 涼子, 大嶋 康義, 滝口 朝子, 木村 慎二, 上路 拓美

    日本呼吸ケア・リハビリテーション学会誌   25 ( Suppl. )   187s - 187s   2015.9

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  • 鼻腔通気度と鼻症状がCPAPの使用に与える影響

    大嶋 康義, 穂苅 諭, 鈴木 涼子, 小屋 俊之, 各務 博, 菊地 利明

    日本睡眠学会定期学術集会プログラム・抄録集   40回   229 - 229   2015.7

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  • 2型呼吸不全への抗ミトコンドリア抗体に関連した筋炎の影響

    大嶋 康義, 鈴木 涼子, 穂苅 諭, 小屋 俊之, 各務 博, 高田 俊範, 鈴木 榮一, 成田 一衛

    日本呼吸器学会誌   4 ( 増刊 )   311 - 311   2015.3

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  • 閉塞性細気管支炎様症状をきたした水疱性類天疱瘡の1例

    隅田 優介, 橋立 英樹, 三尾 圭司, 吉田 暁, 小林 かおり, 穂苅 諭, 富山 勝博

    新潟市民病院医誌   35 ( 1 )   94 - 94   2014.9

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  • 閉塞性細気管支炎を合併した抗ラミニン332類天疱瘡の1例

    折目 真理, 富山 勝博, 吉田 暁, 穂苅 諭, 橋立 英樹, 河井 一浩, 石井 文人, 橋本 隆

    日本皮膚科学会雑誌   124 ( 3 )   352 - 352   2014.3

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  • 新潟市民病院呼吸器内科におけるNHCAP症例の重症度評価指標の検討

    小泉 健, 森谷 梨加, 穂苅 諭, 手塚 貴文, 伊藤 和彦, 塚田 弘樹

    日本呼吸器学会誌   3 ( 増刊 )   195 - 195   2014.3

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  • 皮膚病変を合併した閉塞性細気管支炎の2剖検例

    橋立 英樹, 渋谷 宏行, 三間 紘子, 三尾 圭司, 富山 勝博, 折目 真理, 五十嵐 可奈子, 田中 登希子, 小泉 健, 穂苅 諭

    日本病理学会会誌   103 ( 1 )   338 - 338   2014.3

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  • COPDが術後呼吸器合併症に与える影響について

    韮澤 紀文, 大嶋 康義, 滝口 朝子, 中山 秀章, 穂苅 諭, 木村 慎二, 上路 拓美

    日本呼吸ケア・リハビリテーション学会誌   23 ( Suppl. )   217s - 217s   2013.9

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  • OSAS患者におけるCPAP内部データとPSGデータの検討

    大嶋 康義, 穂苅 諭, 中山 秀章, 高田 俊範, 鈴木 栄一, 成田 一衛

    日本睡眠学会定期学術集会プログラム・抄録集   38回   209 - 209   2013.6

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  • 膠原病関連間質性肺炎に対するミコフェノール酸モフェチルの当院での使用経験

    朝川 勝明, 市川 紘将, 穂苅 諭, 坂上 拓郎, 小屋 俊之, 高田 俊範, 成田 一衛, 鈴木 栄一

    日本呼吸器学会誌   2 ( 増刊 )   194 - 194   2013.3

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  • 新潟市民病院呼吸器内科における肺炎症例と肺炎重症度評価指標の検討

    小泉 健, 柴田 怜, 穂苅 諭, 手塚 貴文, 伊藤 和彦, 塚田 弘樹

    日本呼吸器学会誌   2 ( 増刊 )   246 - 246   2013.3

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  • OSAS患者におけるCPAP内部データの正確性の検討

    大嶋 康義, 穂苅 諭, 中山 秀章, 高田 俊範, 鈴木 栄一, 成田 一衛

    日本呼吸器学会誌   2 ( 増刊 )   227 - 227   2013.3

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  • 非移植例における閉塞性細気管支炎3例の長期経過

    穂苅諭, 柴田怜, 小泉健, 手塚貴文, 伊藤和彦, 塚田弘樹

    日本呼吸器学会誌   2   2013

  • 当院における人工呼吸器管理中の患者に対するリハビリスタッフと呼吸器内科医の連携について

    大脇教光, 大滝直子, 遠藤直人, 穂苅諭, 大嶋康義, 中山秀章, 高田俊範, 成田一衛

    日本呼吸ケア・リハビリテーション学会誌   22   2012

  • 【しくみを図解・まるごと理解 呼吸運動異常の「なるほど」】 呼吸器疾患別呼吸パターンの異常からよみとく呼吸運動異常の観察方法 睡眠時無呼吸症候群 Reviewed

    大嶋 康義, 穂苅 諭, 中山 秀章

    呼吸器ケア   9 ( 12 )   1268 - 1271   2011.12

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Presentations

  • BP賞選考セッション3:睡眠時無呼吸症候群におけるCPAP機器による呼吸イベント判定の信頼性の検討

    穂苅諭, 大嶋康義, 鈴木涼子, 高橋敦宣, 永井明日香, 島賢治郎, 青木信将, 渡部聡, 小屋俊之, 菊地利明

    日本睡眠学会第47回定期学術集会  2022.6 

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  • 学術講演会演題賞(学術部会賞)選考講演会:成人ARDSに対する呼吸補助療法中の肺炎リスクの比較~ネットワークメタ解析を用いて~

    穂苅諭, 木全俊介, 岡野弘, 櫻谷正明, 増山智之

    第62回日本呼吸器学会学術講演会  2022.4 

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  • 慢性II型呼吸不全に潜在する抗ミトコンドリア抗体陽性筋炎 ~抗ミトコンドリアM2抗体スクリーニングの有用性~

    穂苅 諭, 大嶋 康義, 高橋 敦宣, 永井 明日香, 鈴木 涼子, 島 賢治郎, 青木 信将, 渡部 聡, 小屋 俊之, 菊地 利明

    第94回閉塞性肺疾患研究会  2021.7 

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  • 優秀演題 一般演題口演:成人ARDSに対する呼吸補助療法中の肺炎発症の比較 ~システマティックレビューとネットワークメタ解析を用いて~

    穂苅諭, 木全俊介, 岡野弘, 櫻谷正明, 増山智之, 勝田知也, 滝本浩平

    第43回日本呼吸療法医学会学術集会  2021.7 

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  • 小細胞肺癌細胞と非小細胞肺癌細胞におけるTTF-1結合領域の比較解析

    穂苅 諭, 田村 佑介, 金田 篤志, 桂 彰宏, 森川 真大, 江幡 正悟, 堤 修一, 石川 雄一, 油谷 浩幸, 菊地 利明, 宮園 浩平, 鯉沼 代造

    日本癌学会総会記事  2020.10  (一社)日本癌学会

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  • TTF-1 binding regions in small cell lung cancer cells International conference

    Hokari S, Katsura A, Tamura Y, Kikuchi T, Koinuma D, Miyazono K

    The 6th JCA-AACR Special Joint Conference  2018.7 

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  • 多系統萎縮症に合併した閉塞性睡眠時無呼吸における呼吸不安定性の検討~ポリソムノグラフィを用いた近似エントロピーを用いて~

    穂苅諭, 中山秀章, 大嶋康義, 松戸隆之, 下畑享良

    第58回睡眠呼吸障害研究会  2021.2 

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  • 当院における消化器手術の術前スクリーニングと周術期呼吸リハビリの現状

    穂苅 諭

    第28回日本呼吸ケア・リハビリテーション学会学術集会  2018.11 

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  • 睡眠呼吸障害・リハビリテーション 当院における肺切除術後の呼吸器合併症と術前呼吸リハビリテーションの現状

    穂苅 諭, 大嶋 康義, 鈴木 涼子, 小屋 俊之, 各務 博, 土田 正則, 菊地 利明

    第56回日本呼吸器学会学術講演会  2016.3 

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  • Preoperative screening with respiratory failure risk index reduces postoperative pulmonary complications in esophagectomy patients. International conference

    Hokari S, Ohshima Y, Shima K, Moriya R, Koya T, Kagamu H, Tsukada H, Takada T, Kikuchi T

    The 25th International Congress of the European Respiratory Society  2015.9 

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  • 術後呼吸不全リスク指数を用いた術前スクリーニングは食道癌術後の呼吸器合併症を減少させる

    穂苅 諭, 大嶋 康義, 島 賢治郎, 小屋 俊之, 各務 博, 塚田 弘樹, 菊地 利明

    日本呼吸ケア・リハビリテーション学会誌  2015.9 

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  • ミニシンポジウム 睡眠呼吸障害の病態生理と治療:閉塞性睡眠時無呼吸に対するCPAP療法はアルブミン尿を改善する

    穂苅 諭, 大嶋 康義, 鈴木 涼子, 小屋 俊之, 各務 博, 高田 俊範, 鈴木 栄一, 成田 一衛

    第55回日本呼吸器学会学術講演会  2015.3 

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  • 消化管手術後の呼吸器合併症リスク評価の検討 多因子リスクスコアの比較

    穂苅 諭, 大嶋 康義, 中山 秀章, 高田 俊範, 成田 一衛, 鈴木 栄一

    第52回日本呼吸器学会学術講演会  2012.3 

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  • 骨髄異形成症候群を伴い両肺浸潤影による呼吸不全で致命的な経過をとった VEXAS症候群の一例

    宮加谷昌紀, 穂苅諭, 佐藤和茂, 柴田怜, 木村陽介, 島賢治郎, 青木信将, 大嶋康義, 渡部聡, 小屋俊之, 菊地利明, 川上絢子, 増子正義

    第89回呼吸器合同北陸地方会  2022.10 

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  • 我が国の慢性閉塞性肺疾患の診断率は向上しているのか? ~術前スパイロメトリで診断される気流閉塞例の推移~

    穂苅諭, 大嶋康義, 菊地利明

    第95回閉塞性肺疾患研究会  2022.7 

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  • 多系統萎縮症に合併した閉塞性睡眠時無呼吸における呼吸不安定性の検討 ポリソムノグラフィを用いたエントロピー解析

    穂苅 諭, 中山 秀章, 大嶋 康義, 松戸 隆之, 下畑 享良, 菊地 利明

    第61回日本呼吸器学会学術講演会  2021.4  (一社)日本呼吸器学会

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  • 閉塞性睡眠時無呼吸におけるCPAPデータを用いた治療効果のモニタリングは有用か?

    穂苅 諭, 藤戸 信宏, 鈴木 涼子, 大嶋 康義, 青木 信将, 林 正周, 渡部 聡, 小屋 俊之, 菊地 利明

    第60回日本呼吸器学会学術講演会  2020.9  (一社)日本呼吸器学会

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  • TTF-1 binding regions in small cell lung cancer cells.

    Hokari S, Tamura Y, Katsura A, Kikuchi T, Koinuma D, Miyazono K

    TGF-β Meeting in Uppsala  2017.9 

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  • 閉塞性睡眠時無呼吸症候群患者における慢性間欠的低酸素血症が腎尿細管間質障害におよぼす影響の検討

    森谷梨加, 穂苅諭, 大嶋康義, 鈴木涼子, 永井明日香, 高橋敦宣, 島賢治郎, 青木信将, 渡部聡, 小屋俊之, 菊地利明

    第31回PneumoForum  2022.10 

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  • 肺胞低換気を契機に診断された球脊髄性筋萎縮症の1例

    藁谷友, 穂苅諭, 高橋敦宣, 島賢治郎, 大嶋康義, 菊地利明, 渡邉緑, 徳武孝允, 小野寺理, 寺田正樹

    第150回日本内科学会信越地方会  2022.6 

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  • 肺胞低換気と上腸間膜動脈症候群を呈し、ALPL遺伝子変異を認めたSilver-Russell症候群の成人例

    渡辺裕介, 穂苅諭, 袴田真理子, 大嶋康義, 島賢次郎, 青木信将, 渡部聡, 小屋俊之, 菊地利明, 鏡雅代

    医学生・研修医の日本内科学会ことはじめ2022 京都  2022.4 

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  • 息苦しくて入浴できない57歳男性 ~呼吸様式から考える呼吸不全~ Invited

    穂苅 諭

    令和4年度第1回Monthly新潟呼吸器道場  2022.4 

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  • 閉塞性睡眠時無呼吸症候群患者における慢性間欠的低酸素血症が腎尿細管間質障害におよぼす影響の検討

    森谷梨加, 穂苅諭, 鈴木涼子, 大嶋康義, 永井明日香, 高橋敦宣, 菊谷多鶴子, 島賢治郎, 青木信将, 渡部聡, 小屋俊之, 菊地利明

    第59回睡眠呼吸障害研究会  2022.2 

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  • 細菌性肺炎として初期治療を開始されたANCA関連血管炎の2例

    木村光弘, 久代航平, 穂苅諭, 永井明日香, 島賢治郎, 青木信将, 大嶋康義, 渡部聡, 小屋俊之, 菊地利明

    第149回日本内科学会信越地方会  2021.10 

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  • 呼吸器感染症を契機に発見されたGood症候群の2例

    久代航平, 穂苅諭, 柴田怜, 倉科健司, 佐藤佑輔, 尾形英至, 外山美央, 島賢治郎, 青木信将, 大嶋康義, 渡部聡, 小屋俊之, 菊地利明

    第86回呼吸器合同北陸地方会  2021.5 

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  • 多系統萎縮症に合併した閉塞性睡眠時無呼吸における呼吸不安定性の検討 ~ポリソムノグラフィを用いたエントロピー解析の応用可能性~

    穂苅諭, 中山秀章, 大嶋康義, 松戸隆之, 下畑享良

    第29回PneumoForum  2020.11 

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  • 閉塞性睡眠時無呼吸におけるCPAP機器の残存呼吸イベント判定の有用性

    穂苅諭, 藤戸信宏, 鈴木涼子, 大嶋康義, 青木信将, 林正周, 渡部聡, 小屋俊之, 菊地利明

    第29回日本呼吸ケア・リハビリテーション学会学術集会  2019.11 

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  • シェーグレン症候群による胸膜炎の一例

    中流光, 穂苅諭, 林正周, 上野浩志, 大坪亜矢, 月岡啓輔, 庄子聡, 青木信将, 大嶋康義, 渡部聡, 小屋俊之, 菊地利明

    第83回呼吸器合同北陸地方会  2019.11 

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  • ジアフェニルスルホン(DDS)による薬剤性メトヘモグロビン血症の3例

    風間はづき, 穂苅諭, 南雲駿, 尾方英至, 小泉健, 市川紘将, 青木信将, 渡部聡, 小屋俊之, 菊地利明

    第145回日本内科学会信越地方会  2019.10 

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  • 閉塞性睡眠時無呼吸におけるCPAP機器の残存呼吸イベント判定の有用性

    穂苅諭, 藤戸信宏, 鈴木涼子, 大嶋康義, 渡部聡, 小屋俊之, 菊地利明

    第16回新潟睡眠呼吸障害研究会  2019.9 

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  • ミニシンポジウム 肺癌 基礎:肺小細胞癌細胞におけるTTF-1結合領域の網羅的解析

    穂苅諭, 森川真大, 桂彰宏, 田村佑介, 村井文彦, 江幡正悟, 菊地利明, 鯉沼代造, 宮園浩平

    第59回日本呼吸器学会学術講演会  2019.4 

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  • 先端巨大症治療の睡眠呼吸障害への効果

    穂苅 諭, 大嶋 康義, 鈴木 涼子, 小屋 俊之, 菊地 利明

    2017.3 

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  • 当院における間質性肺炎患者の夜間パルスオキシメトリー検査の現況

    穂苅 諭, 大嶋 康義, 鈴木 涼子, 小屋 俊之, 菊地 利明

    日本睡眠学会定期学術集会プログラム・抄録集  2016.7 

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  • CPAPについて Invited

    穂苅 諭

    新潟大学医歯学総合病院看護部 キャリア開発支援研修 呼吸ケア・基礎編  2016.6 

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  • 先端巨大症治療後に睡眠呼吸障害は軽快するか?

    穂苅諭, 大嶋康義, 鈴木涼子, 小屋俊之, 各務博, 菊地利明

    第12回新潟睡眠呼吸障害研究会  2015.10 

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  • 先端巨大症治療後に睡眠呼吸障害は軽快するか?

    穂苅 諭, 大嶋 康義, 鈴木 涼子, 小屋 俊之, 各務 博, 菊地 利明

    日本睡眠学会定期学術集会プログラム・抄録集  2015.7 

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  • 消化管手術後の呼吸器合併症リスク評価の検討~多因子リスクスコアの比較~

    穂苅諭, 大嶋康義, 中山秀章, 鈴木涼子, 梶原大季, 小屋俊之, 各務博, 高田俊範, 鈴木栄一, 成田一衛

    腎・膠原病・呼吸器・感染症研究会  2014.12 

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  • 睡眠時無呼吸症候群について Invited

    穂苅 諭

    第23回にいがた臨床研究会  2014.10 

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  • 粘膜類天疱瘡を伴う閉塞性細気管支炎の1剖検例(An autopsy case of bronchiolitis obliterans associated with mucous membrane pemphigoid)

    穂苅 諭, 森谷 梨加, 小泉 健, 手塚 貴文, 伊藤 和彦, 富山 勝博, 吉田 暁, 橋立 英樹, 塚田 弘樹

    第54回日本呼吸器学会学術講演会  2014.3 

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  • 類天疱瘡に伴う閉塞性細気管支炎の経過中に、アスペルギルス感染症で死亡した1剖検例

    穂苅諭, 森谷梨加, 小泉健, 手塚貴文, 伊藤和彦, 塚田弘樹, 富山勝博, 吉田暁, 橋立英樹

    第20回新潟抗酸菌・気道感染研究会  2013.10 

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  • 非移植例における閉塞性細気管支炎3例の長期経過

    穂苅 諭, 柴田 怜, 小泉 健, 手塚 貴文, 伊藤 和彦, 塚田 弘樹

    第53回日本呼吸器学会学術講演会  2013.3 

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  • 腎移植後に閉塞性換気障害がみられた一例

    穂苅諭, 中山秀章, 森山寛史, 高田俊範, 成田一衛, 鈴木栄一, 中川由紀, 斎藤和英, 高橋公太, 土田正則

    第17回びまん性肺疾患セミナー  2013.2 

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  • 生体腎移植後に閉塞性障害を呈した1例

    穂苅諭, 中山秀章, 森山寛史, 高田俊範, 成田一衛

    第70回日本呼吸器学会北陸地方会  2012.11 

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  • 生体腎移植後に閉塞性障害を呈した1例

    穂苅諭, 中山秀章, 森山寛史, 高田俊範, 成田一衛, 鈴木栄一, 中川由紀, 斎藤和英, 高橋公太, 土田正則

    第45回チェストカンファレンス総会  2012.7 

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  • 先端巨大症患者における肺胞低換気と睡眠呼吸障害

    穂苅 諭, 大嶋 康義, 中山 秀章, 高田 俊範, 鈴木 栄一, 成田 一衛

    日本睡眠学会定期学術集会プログラム・抄録集  2012.6 

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  • Obstructive Sleep Apnea is Associated with Urinary Albumin Excretion in Japanese Patients. International conference

    Hokari S, Ohshima Y, Nakayama H, Takada T, Suzuki E, Narita I

    The 26th Annual Meeting of the Associated Professional Sleep Societies  2012.6 

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  • 閉塞性睡眠時無呼吸は尿中アルブミン排泄を増加させる

    穂苅 諭, 中山 秀章, 大嶋 康義, 高田 俊範, 鈴木 栄一, 成田 一衛

    第109回日本内科学会講演会  2012.2 

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  • Does respiratory irregularity contribute the pathogenesis of sleep-disordered breathing in multiple system atrophy? International conference

    Hokari S, Nakayama H, Matsuto T, Shimohata T, Takada T, Ozawa T, Nishizawa M, Suzuki E, Narita I

    The 21st Annual Congress of the European Respiratory Society  2011.9 

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  • 睡眠時無呼吸を契機に発見された筋強直性ジストロフィーの1例

    松尾浩司, 穂苅諭, 鈴木涼子, 中山秀章, 高田俊範, 成田一衛

    第67回日本呼吸器学会北陸地方会  2011.6 

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  • 呼吸の不安定性は多系統萎縮症患者の睡眠時無呼吸に関与するか?

    穂苅 諭, 鈴木 涼子, 中山 秀章, 高田 俊範, 成田 一衛, 鈴木 栄一, 下畑 享良, 小澤 鉄太郎, 西澤 正豊

    第51回日本呼吸器学会学術講演会  2011.3 

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  • NPPV により著明に呼吸機能が改善した肥満低換気症候群の1 例

    穂苅諭, 鈴木涼子, 中山秀章, 高田俊範, 成田一衛

    第46回睡眠呼吸障害研究会  2011.2 

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  • NPPV により著明に呼吸機能が改善した肥満低換気症候群の1 例

    穂苅諭, 鈴木涼子, 中山秀章, 各務博, 高田俊範, 成田一衛

    第66回日本呼吸器学会北陸地方会  2010.11 

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  • 低肺機能患者における周術期呼吸リハビリテーションの検討

    穂苅 諭, 梶原 大季, 中山 秀章, 高田 俊範, 鈴木 栄一

    第50回日本呼吸器学会学術講演会  2010.3 

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  • 低肺機能患者における周術期呼吸リハビリテーションの検討

    穂苅諭, 梶原大季, 中山秀章, 高田俊範, 鈴木栄一

    第22回新潟在宅呼吸療法研究会  2009.12 

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  • 維持透析療法に至った抗GBM抗体型急速進行性糸球体腎炎の1例

    穂苅諭, 安宅謙

    第39回山形腎不全研究会  2008.12 

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  • Stiff-person症候群に合併した間質性肺炎の1例

    穂苅諭, 島岡雄一, 富士盛文夫, 岡島正明, 栗山英之, 小屋俊之, 田中純太, 中山秀章, 各務博, 寺田正樹, 高田俊範, 下条文武

    第61回日本呼吸器学会北陸地方会  2008.5 

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  • 原発性胆汁性肝硬変症患者に合併した毛細血管塞栓型クリプトコッカス症の一剖検例

    穂苅諭, 中嶋治彦, 塚田弘樹, 原口通比古

    第59回日本呼吸器学会北陸地方会  2007.5 

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Awards

  • 日本内科学会ことはじめ 2022 京都 優秀指導者賞

    2022.4   第119回日本内科学会総会・講演会   肺胞低換気と上腸間膜動脈症候群を呈し、ALPL遺伝子変異を認めたSilver-Russell症候群の成人例

    穂苅 諭

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  • First Place: The 43rd Annual Meeting of the Japanese Society of Respiratory Care Medicine

    2021.7  

    Satoshi Hokari

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  • First Place: The 58th Annual Meeting of Sleep-disordered Breathing Reserch Society

    2021.2  

    Satoshi Hokari

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  • Japanese Respiratory Foundation Grant

    2021   Elucidation of Transformation Mechanisms in Lung Cancer Based on Comprehensive Epigenomic Analysis

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  • A Winner of Niigata University Outstanding Paper Award, 2021

    2021   Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer

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  • The Yujin Young Investigator Award

    2020   Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer

    Satoshi Hokari

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  • Presentation Award: The 29th Annual Meeting of the Japan Society for Respiratory Care and Rehabilitation

    2019.11  

    Satoshi Hokari

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  • 第89回呼吸器合同北陸地方会研修医セッション優秀演題賞(指導演題)

    2022.10   骨髄異形成症候群を伴い両肺浸潤影による呼吸不全で致命的な経過をとった VEXAS症候群の一例

    宮加谷昌紀, 穂苅諭

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  • 第31回PneumoForum 優秀賞(指導演題)

    2022.10   閉塞性睡眠時無呼吸症候群患者における慢性間欠的低酸素血症が腎尿細管間質障害におよぼす影響の検討

    森谷梨加, 穂苅諭, 大嶋康義, 鈴木涼子, 永井明日香, 高橋敦宣, 島賢治郎, 青木信将, 渡部聡, 小屋俊之, 菊地利明

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  • 第59回睡眠呼吸障害研究会 優秀賞(指導演題)

    2022.2   閉塞性睡眠時無呼吸症候群患者における慢性間欠的低酸素血症が腎尿細管間質障害におよぼす影響の検討

    森谷梨加, 穂苅諭, 鈴木涼子, 大嶋康義, 永井明日香, 高橋敦宣, 菊谷多鶴子, 島賢治郎, 青木信将, 渡部聡, 小屋俊之, 菊地利明

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  • 腎・膠原病・呼吸器・感染症研究会 優秀賞

    2014.12   腎・膠原病・呼吸器・感染症研究会   消化管手術後の呼吸器合併症リスク評価の検討 多因子リスクスコアの比較

    穂苅 諭

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  • 新潟大学国際会議研究発表支援事業学術奨励費

    2012   Obstructive Sleep Apnea is Associated with Urinary Albumin Excretion in Japanese Patients

    穂苅 諭

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  • 新潟大学国際会議研究発表支援事業学術奨励費

    2011   Does respiratory irregularity contribute to the pathogenesis of sleep-disordered breathing in multiple system atrophy?

    穂苅 諭

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Research Projects

  • Elucidation of Transformation Mechanisms in Lung Cancer Based on Comprehensive Epigenomic Analysis

    Grant number:21K16112  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists  Grant-in-Aid for Early-Career Scientists

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • Elucidation of Transformation Mechanisms in Lung Cancer Based on Comprehensive Epigenomic Analysis

    2021

    Japanese Respiratory Foundation Grant 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000

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  • がんの分子診断法開発

    2017.4 - 2019.3

    日本医療研究開発機構(AMED)  がん治療標的探索プロジェクト 

    宮園浩平、江幡正悟、穂苅 諭

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    Authorship:Coinvestigator(s)  Grant type:Competitive

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  • Evaluation of preoperative risk assessment and pulmonary rehabilitation for prevention of postoperative pulmonary complications

    Grant number:16K21045  2016.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) 

    Hokari Satoshi

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    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

    This study verified two points: (1) validity of preoperative screening using respiratory failure risk index (RFRI), and (2) preventive effect of postoperative pulmonary complications (PPC) by perioperative pulmonary rehabilitation for patients with high risk of PPC.
    Preoperative screening using RFRI made it possible to perform efficient perioperative pulmonary rehabilitation for high-risk patients. On the other hand, the preventive effect of PPC by pulmonary rehabilitation were not shown. It was suggested that the causes were invasiveness of thoracotomy and postoperative swallowing dysfunction.
    In the future, a more multidisciplinary approach is required, mainly targeting thoracic surgery such as esophagectomy and including oral care and swallowing rehabilitation.

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Other research activities

  • 臨床研修指導医講習会修了

    2022.2

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  • 呼吸ケア指導士(初級)

    2019.4

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  • 日本内科学会 内科指導医

    2019

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  • 日本内科学会総合内科専門医

    2017.12

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  • 日本呼吸器学会呼吸器専門医

    2015.12

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  • 日本睡眠学会専門医

    2015.7

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  • 日本結核・非結核性抗酸菌症学会認定医

    2012.3

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Teaching Experience (researchmap)

  • Post-CC OSCE機構課題 評価責任者補佐

    2022.9
    Institution name:新潟大学医学部医学科

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  • e臨床実習II「Advanced 症候学・医⾏為 (⼿技) シリーズ」呼吸療法の実際

    2022.1
    Institution name:新潟大学医学部医学科

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  • 呼吸器・感染症内科学:総論

    2021
    Institution name:新潟大学歯学部

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  • 臨床実習I、臨床実習II(呼吸器・感染症内科 学生実習担当)

    2021
    -
    2022
    Institution name:新潟大学医学部医学科

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  • 3年次医学研究実習

    2021
    Institution name:新潟大学医学部医学科

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  • OSCE評価者

    2020.12
    Institution name:新潟大学医学部医学科

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  • 4年生臨床実習入門OSCE(胸部診察,バイタルサイン,シュミレーター)

    2020
    Institution name:新潟大学医学部医学科

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  • 疾病救急医学I(呼吸器):睡眠時無呼吸、過換気、呼吸不全

    2019
    Institution name:新潟医療技術専門学校

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Social Activities

  • 新潟県立新潟高等学校 医学講演会

    Role(s): Lecturer

    2019 - 2021

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Media Coverage

Academic Activities

  • 第7回日本呼吸ケア・リハビリテーション学会甲信越支部学術集会シンポジウム:みんなで支える呼吸ケア診療について ~多職種チームで支える入院から在宅医療~

    Role(s): Planning, management, etc., Panel moderator, session chair, etc.

    日本呼吸ケア・リハビリテーション学会甲信越支部・公益財団法人 在宅医療助成 勇美記念財団(共催)  2022.6

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    Type:Competition, symposium, etc. 

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  • 新潟呼吸器道場事務局

    Role(s): Planning, management, etc.

    新潟大学大学院医歯学総合研究科 呼吸器・感染症内科学分野  2020 - 2021

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    Type:Academic society, research group, etc. 

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