Updated on 2025/09/17

写真a

 
OGURA Ryosuke
 
Organization
Brain Research Institute Clinical Neuroscience Branch Department of Neurosurgery Assistant Professor
Title
Assistant Professor
External link

Degree

  • 博士（医学） ( 2015.3   新潟大学 )

Research Areas

  • Life Science / Neurosurgery

Research History

  • Niigata University   Department of Neurosurgery, Clinical Neuroscience Branch, Brain Research Institute   Assistant Professor

    2023.12

  • Niigata University   Neurosurgery, University Medical and Dental Hospital   Specially Appointed Assistant Professor

    2022.11 - 2023.11

  • Niigata University   Neurosurgery, University Medical and Dental Hospital   Assistant Professor

    2022.4 - 2022.10

  • Niigata University   University Medical and Dental Hospital Advanced Disaster Medical and Emergency Critical Care Center   Specially Appointed Assistant Professor

    2019.4 - 2022.3

 

Papers

  • Sequential and coexisting bilateral suboccipital cavernous sinus arteriovenous fistulas successfully treated with unilateral transvenous coil embolization: illustrative case. International journal

    Ryosuke Ogura, Kouichirou Okamoto, Toru Takino, Tomoaki Suzuki, Hitoshi Hasegawa, Makoto Oishi

    Journal of neurosurgery. Case lessons   9 ( 25 )   2025.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The suboccipital cavernous sinus (SCS) is a venous compartment surrounding the horizontal segment of the vertebral artery (VAh), from the transverse foramen of the atlas (C1) to the dura mater at the foramen magnum. The SCS is structurally and functionally similar to the cavernous sinus (CS). The CS is frequently involved in dural arteriovenous fistulas (DAVFs), and bilateral CS-DAVFs are not rare. However, SCS-arteriovenous fistulas (SCS-AVFs) are extremely rare, with no documented cases of bilateral occurrence. OBSERVATIONS: A 58-year-old renovation worker presented with a right SCS-AVF and pulsatile tinnitus, which worsened at night. After diagnostic cerebral angiography, his tinnitus slightly improved, but worsened again 6 months later, becoming bilateral and significantly affecting his sleep and daily life. Repeat cerebral angiography demonstrated decreased feeding arteries and draining veins of the right SCS-AVF, with a new left SCS-AVF. Treatment of the dominant left SCS-AVF with ipsilateral transvenous embolization with coils (TVE-c) led to gradual improvement in residual SCS-AVFs, and the tinnitus completely disappeared within 1 year. LESSONS: Similar to bilateral CS-DAVFs, which can be obliterated with unilateral TVE-c, the bilateral SCS-AVFs in this patient were successfully managed with unilateral TVE-c. Treatment strategies for bilateral SCS-AVFs may therefore resemble those for bilateral CS-DAVFs. https://thejns.org/doi/10.3171/CASE25137.

    DOI： 10.3171/CASE25137

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  • Preoperative interactive virtual simulation applying three-dimensional multifusion images using a haptic device for lumbosacral lipoma. International journal

    Ryosuke Ogura, Hidemoto Fujiwara, Manabu Natsumeda, Tetsuya Hiraishi, Masakazu Sano, Makoto Oishi

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery   40 ( 4 )   1129 - 1136   2024.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Untethering surgery for lumbosacral lipoma is a preventive procedure, and avoidance of complications and good long-term outcomes are required. We introduced presurgical interactive virtual simulation (IVS) applying three-dimensional multifusion images using a haptic device aimed at improving operative outcomes. METHODS: Fourteen patients with newly diagnosed lumbosacral lipoma were recruited and underwent preoperative IVS. The median age at surgery was 8 months. A three-dimensional image analysis system was used to extract and fuse structures necessary for surgery, such as the lipoma, spinal cord and skin, from CT and MRI, and create three-dimensional multifusion images. The created images were individually converted to standard triangulated language format and loaded onto a workstation (Geomagic freeform™) that could be freely transformed, and the laminectomy range and lipoma extraction procedure were examined. Presurgical IVS was performed, and the actual surgery was performed. RESULTS: The disease types were dorsal, caudal, lipomyelomeningocele, transitional, and filum in 5, 5, 2, 1, and 1 patients, respectively. The surgical procedure and extent of the laminectomy were as planned for all patients. Resection of the lipomas tended to be less than expected preoperatively because of positive reactions on intraoperative monitoring. No postoperative complications were observed. The median postoperative follow-up period was 29 months, and there were no reoperations during the observation period. CONCLUSIONS: Although there are various types of lumbosacral lipoma, surgery can be safely performed by performing presurgical IVS. The short-term course is good; however, long-term follow-up is necessary for the appearance of neurological symptoms associated with growth and re-tethering.

    DOI： 10.1007/s00381-023-06234-2

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  • [Interactive Virtual Simulation with Haptics for Neurosurgery].

    Makoto Oishi, Ryosuke Ogura

    No shinkei geka. Neurological surgery   52 ( 2 )   279 - 288   2024.3

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    We established a unique pre-surgical simulation method by applying interactive virtual simulation(IVS)using multi-fusion three-dimensional imaging data, presenting high-quality visualization of microsurgical anatomies. Our IVS provided a realistic environment for imitating surgical manipulations, such as dissecting bones, retracting brain tissues, and removing tumors, with tactile and kinesthetic sensations delivered through a specific haptic device. The great advantage of our IVS was in deciding the most appropriate craniotomy and bone resection to create the optimal surgical window and obtain the best working space with a thorough understanding of the lesion-bone relationship. Particularly for skull-base tumors, tailoring the procedures to individual patients for craniotomy and bone resection was sufficiently achieved using our IVS. In cases of large skull base meningiomas, our IVS was also helpful preoperatively regarding tumors, as several compartments were achievable in every potentially usable surgical direction. Additionally, the non-risky realistic microsurgical environments of the IVS provided improvement in the microsurgical senses and skills of young trainees through the repetition of surgical tasks. Finally, our presurgical IVS simulation method provided a realistic environment for practicing microsurgical procedures virtually and enabled us to ascertain the complex microsurgical anatomy, determine optimal surgical strategies, and efficiently educate neurosurgical trainees.

    DOI： 10.11477/mf.1436204912

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  • Preoperative three-dimensional multifusion imaging aiding successful microvascular decompression of a cerebellopontine angle lipoma: associated hemifacial spasm. Illustrative case. International journal

    Hiroki Seto, Ryosuke Ogura, Tetsuya Hiraishi, Yoshihiro Tsukamoto, Taiki Saito, Satoshi Shibuma, Kohei Shibuya, Kouichirou Okamoto, Makoto Oishi, Yukihiko Fujii

    Journal of neurosurgery. Case lessons   5 ( 12 )   2023.3

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Cerebellopontine angle (CPA) lipoma-associated hemifacial spasm (HFS) is rare. As the removal of CPA lipomas has a high risk of worsening the neurological symptoms, surgical exploration is warranted only in selected patients. Preoperative identification of the lipoma affected site of the facial nerve, and offending artery are crucial for patient selection and successful microvascular decompression (MVD). OBSERVATIONS: Presurgical simulation using three-dimensional (3D) multifusion imaging showed a tiny CPA lipoma wedged between the facial and auditory nerves, as well as an affected facial nerve by the anterior inferior cerebellar artery (AICA) at the cisternal segment. Although a recurrent perforating artery from the AICA anchored the AICA to the lipoma, successful MVD was achieved without lipoma removal. LESSONS: The presurgical simulation using 3D multifusion imaging could identify the CPA lipoma, affected site of the facial nerve, and offending artery. It was helpful for patient selection and successful MVD.

    DOI： 10.3171/CASE2318

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  • Near-Infrared Photoimmunotherapy in Brain Tumors-An Unexplored Frontier. International journal

    Haruka Yamaguchi, Masayasu Okada, Takuya Otani, Jotaro On, Satoshi Shibuma, Toru Takino, Jun Watanabe, Yoshihiro Tsukamoto, Ryosuke Ogura, Makoto Oishi, Takamasa Suzuki, Akihiro Ishikawa, Hideyuki Sakata, Manabu Natsumeda

    Pharmaceuticals (Basel, Switzerland)   18 ( 5 )   2025.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer treatment that uses near-infrared light to activate a conjugate of a monoclonal antibody (mAb) and a photoactivatable silica phthalocyanine dye (IRDye700DX: IR700). Unlike conventional photodynamic therapy (PDT), NIR-PIT selectively destroys targeted tumor cells while preserving the surrounding normal tissue and providing superior tissue penetration. Recently, NIR-PIT has been approved for the treatment of unresectable recurrent head and neck cancers in Japan. It induces highly selective cancer cell death; therefore, it is expected to be a new curative treatment option for various cancers, including brain tumors. In this review, we compare the principles of NIR-PIT and PDT and discuss the potential applications of NIR-PIT for brain tumors. We selected targetable proteins across various types of brain tumors and devised a strategy to effectively pass the mAb-IR700 conjugate through the blood-brain barrier (BBB), which is a significant challenge for NIR-PIT in treating brain tumors. Innovative approaches for delivering the mAb-IR700 conjugate across the BBB include exosomes, nanoparticle-based systems, and cell-penetrating peptides. Small-molecule compounds, such as affibodies, are anticipated to rapidly accumulate in tumors within intracranial models, and our preliminary experiments demonstrated rapid uptake. NIR-PIT also induces immunogenic cell death and activates the anti-tumor immune response. Overall, NIR-PIT is a promising approach for treating brain tumors. It has the potential to overcome the limitations of conventional therapies and offers new hope to patients with brain tumors.

    DOI： 10.3390/ph18050751

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  • Syringomyelia Associated with Magendie's Foramen Obstruction Due to Probably Congenital Gliomesenchymal Anomaly.

    Shunsuke Kumagai, Ryosuke Ogura, Kohei Shibuya, Jotaro On, Shoji Saito, Masakazu Sano, Akiyoshi Kakita, Makoto Oishi

    NMC case report journal   12   221 - 226   2025

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    We report a case of syringomyelia in a 55-year-old man with a unique obstruction of Magendie's foramen. Spinal magnetic resonance imaging revealed a large syrinx extending from C1 to C3, with intermittent syringomyelia extending down to Th11. While the obstruction was not clearly evident on T2-weighted imaging, three-dimensional constructive interference in steady-state imaging demonstrated a thickened membranous tissue blocking the cerebrospinal fluid outlet, leading to syrinx formation. Surgical intervention, involving the resection of the thickened membrane to open the foramen of Magendie, resulted in considerable improvement in the syringomyelia and neurological symptoms. Histopathological examination revealed gliomesenchymal tissue, suggesting an embryonic origin of the obstruction. This case highlights the importance of detailed imaging, particularly three-dimensional constructive interference in steady-state sequence, in diagnosing foramen of Magendie obstruction and the potential for successful surgical treatment in selected cases. Histopathological examination is crucial for differentiating gliomesenchymal tissue from adhesive arachnoiditis.

    DOI： 10.2176/jns-nmc.2025-0041

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  • 脳腫瘍1 Diffuse midline gliomaにおける髄液中H3K27M変異検出は髄膜播種を予測する

    棗田 学, 温 城太郎, 渋間 聡, 高橋 陽彦, 渡邉 潤, 塚本 佳広, 小倉 良介, 岡田 正康, 大石 誠

    小児の脳神経   49 ( 2 )   128 - 128   2024.4

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    Language：Japanese   Publisher：(一社)日本小児神経外科学会  

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  • Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis. International journal

    Haruhiko Takahashi, Manabu Natsumeda, Norikazu Hara, Akihide Koyama, Hiroshi Shimizu, Akinori Miyashita, Daiken Satake, Yoshihiro Mouri, Jun Tsukano, Keita Kawabe, Yoshihiro Tsukamoto, Masayasu Okada, Ryosuke Ogura, Akihiko Yuki, Hajime Umezu, Akiyoshi Kakita, Takeshi Ikeuchi, Makoto Oishi

    Acta neuropathologica communications   12 ( 1 )   14 - 14   2024.1

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    Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by congenital melanocytic nevus of skin and abnormal proliferation of leptomeningeal melanocytes. Early acquisition of post-zygotic somatic mutations has been postulated to underlie the pathogenesis of NCM. The pathogenesis of NCM remains to be fully elucidated, and treatment options have not been established. Here, we report for the first time, multiregional genomic analyses in a 3-year-old autopsied girl with leptomeningeal melanomatosis associated with NCM, in which a ventriculo-peritoneal (VP) shunt was inserted for the treatment of hydrocephalus. The patient expired six months after the onset due to respiratory failure caused by abdominal dissemination via VP shunt. We performed multiregional exome sequencing to identify genomic differences among brain and abdominal tumors, nevus, and normal tissues. A total of 87 somatic mutations were found in 71 genes, with a significantly large number of gene mutations found in the tumor site. The genetic alterations detected in the nevus were only few and not shared with other sites. Three mutations, namely GNAQ R183Q, S1PR3 G89S and NRAS G12V, considered pathogenic, were found, although S1PR3 mutations have not been previously reported in melanocytic tumors. GNAQ and S1PR3 mutations were shared in both tumor and normal sites. Moreover, the mutant allele frequencies of the two mutations were markedly higher in tumor sites than in normal sites, with copy-neutral loss-of-heterozygosity (CN-LOH) occurring in tumor. NRAS mutation was found only in the abdominal tumor and was thought to be responsible for malignant progression in the present case. Multiregional comprehensive genetic analysis may lead to discovering novel driver mutations associated with tumorigenesis and targeted therapy.

    DOI： 10.1186/s40478-024-01723-0

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  • Reliable detection of genetic alterations in cyst fluid DNA for the diagnosis of brain tumors. International journal

    Jotaro On, Manabu Natsumeda, Haruhiko Takahashi, Akihide Koyama, Satoshi Shibuma, Nao Shibata, Jun Watanabe, Shoji Saito, Yu Kanemaru, Yoshihiro Tsukamoto, Masayasu Okada, Ryosuke Ogura, Takeyoshi Eda, Mari Tada, Hiroshi Shimizu, Jun-Ichi Adachi, Kazuhiko Mishima, Ryo Nishikawa, Akiyoshi Kakita, Makoto Oishi

    Journal of neuro-oncology   166 ( 2 )   273 - 282   2024.1

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    PURPOSE: Liquid biopsy of cyst fluid in brain tumors has not been extensively studied to date. The present study was performed to see whether diagnostic genetic alterations found in brain tumor tissue DNA could also be detected in cell-free DNA (cfDNA) of cyst fluid in cystic brain tumors. METHODS: Cyst fluid was obtained from 22 patients undergoing surgery for a cystic brain tumor with confirmed genetic alterations in tumor DNA. Pathological diagnoses based on WHO 2021 classification and diagnostic alterations in the tumor DNA, such as IDH1 R132H and TERT promoter mutation for oligodendrogliomas, were detected by Sanger sequencing. The same alterations were analyzed by both droplet digital PCR (ddPCR) and Sanger sequencing in cyst fluid cfDNA. Additionally, multiplex ligation-dependent probe amplification (MLPA) assays were performed to assess 1p/19q status, presence of CDKN2A loss, PTEN loss and EGFR amplification, to assess whether differentiating between astrocytomas and oligodendrogliomas and grading is possible from cyst fluid cfDNA. RESULTS: Twenty-five genetic alterations were found in 22 tumor samples. All (100%) alterations were detected in cyst fluid cfDNA by ddPCR. Twenty of the 25 (80%) alterations were also detected by Sanger sequencing of cyst fluid cfDNA. Variant allele frequency (VAF) in cyst fluid cfDNA was comparable to that of tumor DNA (R = 0.62, Pearson's correlation). MLPA was feasible in 11 out of 17 (65%) diffuse gliomas, with close correlation of results between tumor DNA and cyst fluid cfDNA. CONCLUSION: Cell-free DNA obtained from cyst fluid in cystic brain tumors is a reliable alternative to tumor DNA when diagnosing brain tumors.

    DOI： 10.1007/s11060-023-04555-5

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  • 嚢胞形成PRL産生PitNETの治療成績

    岡田 正康, 小倉 良介, 平石 哲也, 米岡 有一郎, 大石 誠

    新潟医学会雑誌   137 ( 12 )   447 - 447   2023.12

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    Language：Japanese   Publisher：新潟医学会  

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  • Preliminary Experience of Photodynamic Therapy for Malignant Gliomas and Shooting for Next-generation Treatment

    Natsumeda Manabu, On Jotaro, Watanabe Jun, Tsukamoto Yoshihiro, Okada Masayasu, Ogura Ryosuke, Hiraishi Tetsuya, Oishi Makoto, Fujii Yukihiko

    The Journal of Japan Society for Laser Surgery and Medicine   44 ( 2 )   95 - 101   2023.7

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  • Diffusely Infiltrating Gliomas With Poor Prognosis, TERT Promotor Mutations, and Histological Anaplastic Pleomorphic Xanthoastrocytoma-Like Appearance Classify as Mesenchymal Type of Glioblastoma, IDH-wildtype by Methylation Analysis. International journal

    Yoshihiro Tsukamoto, Manabu Natsumeda, Haruhiko Takahashi, Jotaro On, Hiroki Seto, Taiki Saito, Kohei Shibuya, Ryosuke Ogura, Junko Ito, Masayasu Okada, Makoto Oishi, Hiroshi Shimizu, Kouichirou Okamoto, Akiyoshi Kakita, Yukihiko Fujii

    Neurosurgery practice   4 ( 2 )   e00040   2023.6

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    BACKGROUND: Pleomorphic xanthoastrocytoma (PXA) (World Health Organization grade II) is classified as a relatively benign and circumscribed glioma; however, anaplastic PXA (APXA, World Health Organization grade III) has a poorer prognosis, and differentiating from glioblastoma can be difficult both histologically and molecularly. OBJECTIVE: To describe the clinical, pathological, and molecular characteristics of diffusely infiltrating gliomas with histological APXA-like features. METHODS: Four diffusely infiltrating gliomas in adult patients histologically diagnosed as APXAs at a single institute were retrospectively reviewed. We analyzed their clinical, radiological, pathological, genetic, epigenetic, and prognostic characteristics. RESULTS: All tumors histologically showed classical characteristic PXA-like appearance with BRAF wildtype, mitotic figure, necrosis, and an increased mindbomb E3 ubiquitin-protein ligase 1 labeling index and were initially diagnosed as APXAs; moreover, they underwent high-grade glioma treatment. Three patients with TERT promotor mutations died within 18 months. These patients' MRIs showed widespread infiltrating fluid-attenuated inversion recovery hyperintense lesions and Gd-enhancing lesions in the bilateral cerebral hemispheres in 2 of the patients. Contrastingly, a patient with the wildtype TERT promotor has survived for 2.5 years without recurrence. MRI revealed an unilateral fluid-attenuated inversion recovery hyperintense and Gd-enhancing lesion. By methylation classifier analysis, all 4 cases clustered toward GBM, IDH-wildtype, mesenchymal type, although one was deemed unclassifiable due to a low calibrated score. CONCLUSION: In diffusely infiltrating gliomas showing histological characteristics of APXA, methylation classification should be performed as these tumors may be difficult to differentiate between glioblastoma, IDH-wildtype by histological or genetic analysis. The aggressive nature of these tumors should be expected, especially in cases that are BRAF-wildtype and TERT promotor mutant.

    DOI： 10.1227/neuprac.0000000000000040

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  • Elucidating the multiple genetic alterations involved in the malignant transformation of a KRAS mutant neurenteric cyst. A case report. International journal

    Shoji Saito, Manabu Natsumeda, Makoto Sainouchi, Toru Takino, Kohei Shibuya, Jotaro On, Yu Kanemaru, Ryosuke Ogura, Masayasu Okada, Makoto Oishi, Yoshifumi Shimada, Toshifumi Wakai, Shujiro Okuda, Yoichi Ajioka, Akiyoshi Kakita, Yukihiko Fujii

    Neuropathology : official journal of the Japanese Society of Neuropathology   42 ( 6 )   519 - 525   2022.9

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    Neurenteric cyst (NC) shows benign histopathology and rarely demonstrate malignant transformation. We herein describe a case of NC that exhibited malignant transformation. A 65-year-old female presented with gait disturbance due to compression by a cystic mass on the dorsal surface of the medulla oblongata. Partial resection was performed twice, leading to improvement of her symptoms. Two years after the second surgery, gadolinium-perfused T1-weighted magnetic resonance imaging revealed an invasive lesion with contrast enhancement at the trigone of the left lateral ventricle for which partial resection followed by radiotherapy was performed. However, mass regrowth was observed, with the patient eventually succumbing to her disease 11 months after her third surgery. Histopathological analyses of the first and second surgical specimens identified pseudostratified cuboidal epithelial cells, with no nuclear or cellular atypia resembling gastrointestinal mucosa, lining the inner surface of the cystic wall. Based on these findings the lesion was diagnosed as NC. The third surgical specimen exhibited apparent malignant features of the epithelial cells with elongated and hyperchromatic nuclei, several mitotic figures, small necrotic foci, and a patternless or sheet-like arrangement. Based on these findings, the lesion was diagnosed as NC with malignant transformation. Next-generation sequencing revealed KRAS p.G12D mutation in all specimens. Additionally, the third surgical specimen harbored the following 12 de novo gene alterations: ARID1A loss, BAP1 p.F170L, CDKN1B loss, CDKN2A loss, CDKN2B loss, FLCN loss, PTCH1 loss, PTEN loss, PTPRD loss, SUFU loss, TP53 loss, and TSC1 loss. The aforementioned results suggest that KRAS mutation is associated with the development of the NC, and that the additional gene alterations contribute to malignant transformation of the NC.

    DOI： 10.1111/neup.12822

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  • 小児・AYA世代のヒストン遺伝子変異びまん性神経膠腫症例の後方視的検討

    塚本 佳広, 高橋 陽彦, 温 城太郎, 小倉 良介, 棗田 学, 岡本 浩一郎, 大石 誠, 柿田 明美, 藤井 幸彦

    Brain Tumor Pathology   39 ( Suppl. )   100 - 100   2022.5

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    Language：Japanese   Publisher：日本脳腫瘍病理学会  

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  • Novel Repositioning Therapy for Drug-Resistant Glioblastoma: In Vivo Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide. International journal

    Takeyoshi Eda, Masayasu Okada, Ryosuke Ogura, Yoshihiro Tsukamoto, Yu Kanemaru, Jun Watanabe, Jotaro On, Hiroshi Aoki, Makoto Oishi, Nobuyuki Takei, Yukihiko Fujii, Manabu Natsumeda

    Cancers   14 ( 3 )   2022.2

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    Multimodal therapy including surgery, radiation treatment, and temozolomide (TMZ) is performed on glioblastoma (GBM). However, the prognosis is still poor and there is an urgent need to develop effective treatments to improve survival. Molecular biological analysis was conducted to examine the signal activation patterns in GBM specimens and remains an open problem. Advanced macrolides, such as azithromycin, reduce the phosphorylation of p70 ribosomal protein S6 kinase (p70S6K), a downstream mammalian target of rapamycin (mTOR) effector, and suppress the proliferation of T-cells. We focused on its unique profile and screened for the antitumor activity of approved macrolide antibiotics. Clindamycin (CLD) reduced the viability of GBM cells in vitro. We assessed the effects of the candidate macrolide on the mTOR pathway through Western blotting. CLD attenuated p70S6K phosphorylation in a dose-dependent manner. These effects on GBM cells were enhanced by co-treatment with TMZ. Furthermore, CLD inhibited the expression of the O6-methylguanine-DNA methyltransferase (MGMT) protein in cultured cells. In the mouse xenograft model, CLD and TMZ co-administration significantly suppressed the tumor growth and markedly decreased the number of Ki-67 (clone MIB-1)-positive cells within the tumor. These results suggest that CLD suppressed GBM cell growth by inhibiting mTOR signaling. Moreover, CLD and TMZ showed promising synergistic antitumor activity.

    DOI： 10.3390/cancers14030770

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  • Detection of 2-Hydroxyglutarate by 3.0-Tesla Magnetic Resonance Spectroscopy in Gliomas with Rare IDH Mutations: Making Sense of "False-Positive" Cases. International journal

    Manabu Natsumeda, Hironaka Igarashi, Ramil Gabdulkhaev, Haruhiko Takahashi, Kunio Motohashi, Ryosuke Ogura, Jun Watanabe, Yoshihiro Tsukamoto, Kouichirou Okamoto, Akiyoshi Kakita, Tsutomu Nakada, Yukihiko Fujii

    Diagnostics (Basel, Switzerland)   11 ( 11 )   2021.11

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    We have previously published a study on the reliable detection of 2-hydroxyglutarate (2HG) in lower-grade gliomas by magnetic resonance spectroscopy (MRS). In this short article, we re-evaluated five glioma cases originally assessed as isocitrate dehydrogenase (IDH) wildtype, which showed a high accumulation of 2HG, and were thought to be false-positives. A new primer was used for the detection of IDH2 mutation by Sanger sequencing. Adequate tissue for DNA analysis was available in 4 out of 5 cases. We found rare IDH2 mutations in two cases, with IDH2 R172W mutation in one case and IDH2 R172K mutation in another case. Both cases had very small mutant peaks, suggesting that the tumor volume was low in the tumor samples. Thus, the specificity of MRS for detecting IDH1/2 mutations was higher (81.3%) than that originally reported (72.2%). The detection of 2HG by MRS can aid in the diagnosis of rare, non-IDH1-R132H IDH1 and IDH2 mutations in gliomas.

    DOI： 10.3390/diagnostics11112129

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  • High grade astrocytomaに準じて治療したprimary anaplastic pleomorphic xanthoastrocytomaの4症例の検討

    塚本 佳広, 棗田 学, 温 城太郎, 小倉 良介, 清水 宏, 岡本 浩一郎, 大石 誠, 藤井 幸彦, 柿田 明美

    Brain Tumor Pathology   38 ( Suppl. )   078 - 078   2021.5

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    Language：Japanese   Publisher：日本脳腫瘍病理学会  

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  • 脳腫瘍遺伝子異常の画像診断 IDH変異型神経膠腫における3T-MRSを用いた2HGの検出

    棗田 学, 五十嵐 博中, 本橋 邦夫, 塚本 佳広, 小倉 良介, 岡本 浩一郎, 大石 誠, 柿田 明美, 藤井 幸彦

    Brain Tumor Pathology   38 ( Suppl. )   059 - 059   2021.5

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  • Four-dimensional multifusion imaging for assessment of meningioma hemodynamics Reviewed

    Ryosuke Ogura, Makoto Oishi, Tetsuya Hiraishi, Haruhiko Takahashi, Kohei Shibuya, Tomoaki Suzuki, Manabu Natsumeda, Kouichirou Okamoto, Yukihiko Fujii

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management   2021.2

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  • マイクロバルーンカテーテルによるflow reductionを併用したOnyx塞栓術

    高橋 陽彦, 安藤 和弘, 渋谷 航平, 齋藤 祥二, 小倉 良介, 鈴木 倫明, 長谷川 仁, 吉村 淳一, 藤井 幸彦

    脳血管内治療   5 ( Suppl. )   83 - 83   2020.11

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    Language：Japanese   Publisher：(NPO)日本脳神経血管内治療学会  

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  • [Surgical Case of Accidental Infantile Acute Subdural Hematoma Caused by Household Minor Head Trauma:Hyperperfusion during Postoperative Hemispheric Hypodensity, Namely "Big Black Brain"].

    Junichi Yoshimura, Manami Morikawa, Shunsuke Kumagai, Taiki Saito, Haruhiko Takahashi, Hidemoto Fujiwara, Ryosuke Ogura, Naoto Tsuchiya

    No shinkei geka. Neurological surgery   48 ( 9 )   841 - 847   2020.9

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    We experienced a case of an accidental infantile acute subdural hematoma caused by household minor head trauma(Nakamura type I intracranial hemorrhage)with postoperative hemispheric hypodensity lesion(Big Black Brain)whose pathophysiology was analyzed using perfusion MRI. A ten-month-old boy was admitted to our hospital in a comatose state. His mother revealed that the boy suffered a fall from a sofa bed. A CT scan indicated massive acute subdural hematoma in the left cerebral hemisphere. Emergency craniotomy and hematoma evacuation were performed. On postoperative day 3, CT revealed hemispheric hypodensity, and the boy suffered from status epilepticus. MRI on the following day showed widespread white matter hyperintensity in diffusion-weighted images, and MRA demonstrated dilation of the middle cerebral artery. Perfusion MRI using the dynamic susceptibility contrast method revealed a marked increase in cerebral blood flow in the left hemisphere. These abnormal MRI and MRA findings disappeared on postoperative day 13. Status epilepticus also improved upon administration of multi-antiepileptic drugs. Fundoscopy findings on postoperative day 3 showed small bilateral petechial or brush retinal hemorrhages. However, whole-body examination did not show any problems, and was consistent with the mother's account. Thus, we judged non-abusive head trauma. Although follow-up MRI showed diffuse atrophy of the left cerebral hemisphere, the boy aged well without obvious paresis or verbal developmental delay as judged by a follow-up more than a year later. Based on these results, we speculated that hyperperfusion caused by dilation of the cerebral artery was related to the postoperative hemispheric hypodensity, namely "Big Black Brain".

    DOI： 10.11477/mf.1436204281

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  • A Case of Curative Onyx Embolization for Tentorial dAVF via Low-flow Feeders with Temporary Balloon Occlusion of High-flow Feeders Reviewed

    Ryosuke Ogura, Hitoshi Hasegawa, Shunsuke Kumagai, Haruhiko Takahashi, Hidemoto Fujiwara, Junichi Yoshimura, Yukihiko Fujii

    Journal of Neuroendovascular Therapy   14 ( 3 )   112 - 117   2020

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    OBJECTIVE: For curative Onyx embolization of dural arteriovenous fistulas (dAVF) with multiple feeders, it is essential to select the optimal target artery as well as to control the blood flow at the fistula point. We report a case of tentorial dAVF (TdAVF) treated by Onyx embolization under flow control using balloon catheters. CASE PRESENTATION: A 66-year-old male was admitted to our hospital for treatment of TdAVF detected incidentally by MRI, which revealed a dilated and tortuous vein around the cerebellum. Cerebral angiography demonstrated a TdAVF, fed mainly by bilateral middle meningeal arteries (MMA) and bilateral occipital arteries (OA), with the fistula point at the torcular and venous drainage to the two superior vermian veins (SVVs). Onyx 18 was injected from the low-flow feeder of the MMA under flow control by occluding the high-flow feeder of the OA using balloon catheters, obliterating the arteriovenous shunt. CONCLUSION: In treatment of TdAVF involving low- and high-flow feeders, Onyx embolization via the low-flow feeder with temporary balloon occlusion of other high-flow feeders is a useful method. This technique makes it easier for Onyx to penetrate the fistula point.

    DOI： 10.5797/jnet.tn.2019-0053

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  • Main feederをバルーンで一時遮断し、細径の標的動脈より根治的ONYX塞栓術を施行し得た小脳テント部硬膜動静脈瘻の1例 Reviewed

    小倉 良介, 長谷川 仁, 熊谷 駿介, 高橋 陽彦, 藤原 秀元, 吉村 淳一, 藤井 幸彦

    脳血管内治療   4 ( Suppl. )   S294 - S294   2019.11

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  • Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy. Reviewed International journal

    Manabu Natsumeda, Kunio Motohashi, Hironaka Igarashi, Takanori Nozawa, Hideaki Abe, Yoshihiro Tsukamoto, Ryosuke Ogura, Masayasu Okada, Tsutomu Kobayashi, Hiroshi Aoki, Hitoshi Takahashi, Akiyoshi Kakita, Kouichirou Okamoto, Tsutomu Nakada, Yukihiko Fujii

    Neurosurgical review   41 ( 2 )   641 - 647   2018.4

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    We have previously reported that reliable detection of 2-hydroxyglutarate (2HG) in isocitrate dehydrogenase (IDH)-mutant WHO grade 2 and 3 gliomas is possible utilizing 3.0-T single-voxel magnetic resonance spectroscopy (SVMRS). We set out to determine whether the same method could be applied to detect 2HG in IDH-mutant glioblastoma. Forty-four patients harboring glioblastoma underwent pre-operative MRS evaluation to detect 2HG and other metabolites. Presence of IDH-mutations was determined by IDH1 R132H immunohistochemical analysis and DNA sequencing of surgically obtained tissues. Six out of 44 (13.6%) glioblastomas were IDH-mutant. IDH-mutant glioblastoma exhibited significantly higher accumulation of 2HG (median 3.191 vs. 0.000 mM, p < 0.0001, Mann-Whitney test). A cutoff of 2HG = 0.897 mM achieved high sensitivity (100.0%) and specificity (92.59%) in determining IDH-mutation in glioblastoma. Glioblastoma with high 2HG accumulation did not have significantly longer overall survival than glioblastoma with low 2HG accumulation (p = 0.107, log-rank test). Non-invasive and reliable detection of 2HG in IDH-mutant glioblastoma was possible by 3.0-T SVMRS.

    DOI： 10.1007/s10143-017-0908-y

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  • Cerebral venous sinus thrombosis due to oral contraceptive use: Postmortem 3 T-MRI and autopsy findings. Reviewed

    Masahiro Uemuraa, Yoshihiro Tsukamoto, Yasuhisa Akaiwa, Masaki Watanabe, Ayako Tazawa, Sou Kasahara, Minoru Endou, Ryosuke Ogura, Kouichirou Okamoto, Yukihiko Fujii, Tsutomu Nakada

    Human Pathology   6 ( 6 )   32 - 36   2016.12

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    DOI： 10.1016/j.ehpc.2016.01.002

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  • Chemical Screening Identifies EUrd as a Novel Inhibitor Against Temozolomide-Resistant Glioblastoma-Initiating Cells. Reviewed International journal

    Yoshihiro Tsukamoto, Naoki Ohtsu, Smile Echizenya, Satoko Otsuguro, Ryosuke Ogura, Manabu Natsumeda, Mizuho Isogawa, Hiroshi Aoki, Satoshi Ichikawa, Masahiro Sakaitani, Akira Matsuda, Katsumi Maenaka, Yukihiko Fujii, Toru Kondo

    Stem cells (Dayton, Ohio)   34 ( 8 )   2016 - 25   2016.8

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    DOI： 10.1002/stem.2380

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  • 当科で経験した成人テント上PNETの2例 症例報告

    塚本 佳広, 小倉 良介, 五十川 瑞穂, 青木 洋, 平石 哲也, 高尾 哲郎, 吉村 淳一, 藤井 幸彦, 高橋 均, 柿田 明美

    Brain Tumor Pathology   33 ( Suppl. )   149 - 149   2016.5

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  • 8 術中脳表NIRSを用いた言語野のcortico-cortical activityの検討 (Ⅰ.一般演題, 第66回新潟脳神経外科懇話会)

    新潟医学会雑誌   130 ( 3 )   210 - 211   2016.3

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  • Immunohistochemical profiles of IDH1, MGMT and P53: practical significance for prognostication of patients with diffuse gliomas. Reviewed International journal

    Ryosuke Ogura, Yoshihiro Tsukamoto, Manabu Natsumeda, Mizuho Isogawa, Hiroshi Aoki, Tsutomu Kobayashi, Seiichi Yoshida, Kouichiro Okamoto, Hitoshi Takahashi, Yukihiko Fujii, Akiyoshi Kakita

    Neuropathology : official journal of the Japanese Society of Neuropathology   35 ( 4 )   324 - 35   2015.8

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    DOI： 10.1111/neup.12196

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  • Cortico-cortical activity between the primary and supplementary motor cortex: An intraoperative near-infrared spectroscopy study. Reviewed International journal

    Masafumi Fukuda, Tetsuro Takao, Tetsuya Hiraishi, Hiroshi Aoki, Ryosuke Ogura, Yosuke Sato, Yukihiko Fujii

    Surgical neurology international   6   44 - 44   2015

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    BACKGROUND: The supplementary motor area (SMA) makes multiple reciprocal connections to many areas of the cerebral cortices, such as the primary motor cortex (PMC), anterior cingulate cortex, and various regions in the parietal somatosensory cortex. In patients with SMA seizures, epileptic discharges from the SMA rapidly propagate to the PMC. We sought to determine whether near-infrared spectroscopy (NIRS) is able to intraoperatively display hemodynamic changes in epileptic network activities between the SMA and the PMC. CASE DESCRIPTIONS: In a 60-year-old male with SMA seizures, we intraoperatively delivered a 500 Hz, 5-train stimulation to the medial cortical surface and measured the resulting hemodynamic changes in the PMC by calculating the oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) concentration changes during stimulation. No hemodynamic changes in the lateral cortex were observed during stimulation of the medial surface corresponding to the foot motor areas. In contrast, both HbO2 and HbR increased in the lateral cortex corresponding to the hand motor areas when the seizure onset zone was stimulated. In the premotor cortex and the lateral cortex corresponding to the trunk motor areas, hemodynamic changes showed a pattern of increased HbO2 with decreased HbR. CONCLUSIONS: This is the first reported study using intraoperative NIRS to characterize the epileptic network activities between the SMA and PMC. Our intraoperative NIRS procedure may thus be useful in monitoring the activities of cortico-cortical neural pathways such as the language system.

    DOI： 10.4103/2152-7806.153872

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  • Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy. Reviewed International journal

    Manabu Natsumeda, Hironaka Igarashi, Toshiharu Nomura, Ryosuke Ogura, Yoshihiro Tsukamoto, Tsutomu Kobayashi, Hiroshi Aoki, Kouichirou Okamoto, Akiyoshi Kakita, Hitoshi Takahashi, Tsutomu Nakada, Yukihiko Fujii

    Acta neuropathologica communications   2   158 - 158   2014.11

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    DOI： 10.1186/s40478-014-0158-y

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  • Cerebral amyloid angiopathy-related leukoencephalopathy: successful steroid treatment for neurological deficits and subcortical white matter lesions partly involving the cortical gray matter Reviewed

    Murakami T, Morimoto J, Hoshi A, Nakatani-Enomoto S, Ichikawa M, Tasaki K, Ogura R, Toyoshima Y, Kakita A, Saito K, Takahashi H, Ugawa Y

    Neurology and Clinical Neuroscience   2 ( 4 )   119 - 121   2014.7

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  • "Gliomatosis encephali" as a novel category of brain tumors by the first autopsy case report of gliomatosis cerebelli. Reviewed International journal

    Asa Nakahara, Toshikazu Yoshida, Masanobu Yazawa, Takashi Ehara, Jun Nakayama, Akiyoshi Kakita, Ryosuke Ogura, Mika Asakawa, Emi Suzuki-Kouyama, Kiyomitsu Oyanagi

    Neuropathology : official journal of the Japanese Society of Neuropathology   34 ( 3 )   295 - 303   2014.6

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    DOI： 10.1111/neup.12083

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  • Entrapment of the inferior horns of the lateral ventricle with enlargement of the bilateral choroid plexus. Reviewed International journal

    Ryosuke Ogura, Junichi Yoshimura, Masakazu Sano, Shouichi Kawasaki, Kenichi Nishiyama, Kouichirou Okamoto, Hitoshi Takahashi, Yukihiko Fujii, Akiyoshi Kakita

    Neuropathology : official journal of the Japanese Society of Neuropathology   34 ( 2 )   210 - 3   2014.4

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    DOI： 10.1111/neup.12072

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  • Neuronal differentiation associated with Gli3 expression predicts favorable outcome for patients with medulloblastoma. Reviewed International journal

    Hiroaki Miyahara, Manabu Natsumeda, Junichi Yoshimura, Ryosuke Ogura, Kenichi Okazaki, Yasuko Toyoshima, Yukihiko Fujii, Hitoshi Takahashi, Akiyoshi Kakita

    Neuropathology : official journal of the Japanese Society of Neuropathology   34 ( 1 )   1 - 10   2014.2

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    DOI： 10.1111/neup.12052

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  • Malignant peripheral nerve sheath tumor of the trigeminal nerve: clinicopathologic features in a young adult patient. Reviewed International journal

    Yoko Nakayama, Masatoshi Watanabe, Kenji Suzuki, Hiroyuki Usuda, Iwao Emura, Ryosuke Ogura, Atsushi Shiga, Yasuko Toyoshima, Hitoshi Takahashi, Tadashi Kawaguchi, Akiyoshi Kakita

    Neuropathology : official journal of the Japanese Society of Neuropathology   33 ( 5 )   541 - 6   2013.10

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    DOI： 10.1111/neup.12004

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  • Epstein-Barr virus-associated primary central nervous system cytotoxic T-cell lymphoma. Reviewed International journal

    Ryosuke Ogura, Hiroshi Aoki, Manabu Natsumeda, Hiroshi Shimizu, Tsutomu Kobayashi, Tomohisa Saito, Jun Takizawa, Kouichirou Okamoto, Go Hasegawa, Hajime Umezu, Kouichi Ohshima, Hitoshi Takahashi, Yukihiko Fujii, Akiyoshi Kakita

    Neuropathology : official journal of the Japanese Society of Neuropathology   33 ( 4 )   436 - 41   2013.8

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    DOI： 10.1111/neup.12005

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  • [Intraoperative monitoring of motor evoked potentials during glioma removal]. Reviewed

    Masafumi Fukuda, Makoto Oishi, Tetsuro Takao, Tetsuya Hiraishi, Tsutomu Kobayashi, Hiroshi Aoki, Ryosuke Ogura, Akihiko Saito, Yukihiko Fujii

    No shinkei geka. Neurological surgery   41 ( 3 )   219 - 27   2013.3

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  • Intraoperative Monitoring of Motor Evoked Potentials during Glioma Removal

    41 ( 3 )   219 - 227   2013.3

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  • Occurrence of metachronous pure germinomas long after treatment of a mixed germ cell tumor containing yolk sac tumor and germinoma. Reviewed International journal

    Shinya Jinguji, Kouichirou Okamoto, Junichi Yoshimura, Yuichiro Yoneoka, Ryousuke Ogura, Akihiko Saito, Yukihiko Fujii

    Journal of neurosurgery. Pediatrics   11 ( 1 )   68 - 73   2013.1

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    The authors report a rare case involving the occurrence of metachronous pure germinomas long after treatment of a mixed germ cell tumor (GCT) categorized as having a poor prognosis. A neurohypophysial germinoma occurred 4 years and 6 months after the initial treatment of a mixed pineal GCT containing a yolk sac tumor and a germinoma. Furthermore, intramedullary germinomas occurred 21 years after the initial treatment of the mixed GCT and 15 years after the second treatment of the neurohypophysial germinoma. The neurohypophysial germinoma was not confirmed histopathologically, but the intramedullary germinoma was histopathologically diagnosed as a pure germinoma. Serum α-fetoprotein levels at the second neurohypophysial and third intramedullary occurrences of the germinomas were less than 10 ng/ml. Therefore, no yolk sac components seemed to be contained in the tumors. The second neurohypophysial and third intramedullary germinomas might be recurrences of the germinoma component of the pineal mixed GCT, which consisted of a yolk sac tumor and a germinoma. However, it seems very unlikely that only the germinoma, categorized in the good prognosis group, would be the only one to recur. Hence, it seems plausible that both the second and the third occurrences of pure germinoma were de novo metachronous GCTs arising after the pineal mixed GCT was cured. The authors' case indicates the possibility of multicentric GCTs in the CNS.

    DOI： 10.3171/2012.9.PEDS12151

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  • Advantages of dose-dense methotrexate protocol for primary central nervous system lymphoma: comparison of two different protocols at a single institution. Reviewed

    Hiroshi Aoki, Ryosuke Ogura, Yoshihiro Tsukamoto, Masayasu Okada, Manabu Natsumeda, Mizuho Isogawa, Seiichi Yoshida, Yukihiko Fujii

    Neurologia medico-chirurgica   53 ( 11 )   797 - 804   2013

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    DOI： 10.2176/nmc.oa2013-0195

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  • Identification of a gene expression signature that predicts outcome in primary central nervous system lymphoma patients Reviewed

    Kawaguchi, A, Iwadate Y, Komohara Y, Sano M, Kajiwara K, Yajima N, Tsuchiya N, Homma J, Ogura R, Natsumeda M, Ideguchi M, Aoki H, Kobayashi T, Sakai Y, Hondoh H, Kakita A, Takahashi H, Suzuki M, Fujii Y, Kakuma T, Yamanaka R

    18 ( 20 )   2012

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Research Projects

  • 難治性髄膜腫に対するSSTR2aを標的とした強化型近赤外光線免疫療法の開発

    Grant number：25K12335

    2025.4 - 2028.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    瀧野 透, 棗田 学, 岡田 正康, 小倉 良介

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    Authorship：Coinvestigator(s) 

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • 難治性髄膜腫に対するSSTR2aを標的とした近赤外光線免疫療法の開発

    Grant number：22K16652

    2022.4 - 2025.3

    System name：科学研究費助成事業

    Research category：若手研究

    Awarding organization：日本学術振興会

    小倉 良介

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • Research of the induction of autophagy and the suppression mechanism in MGMT activity by vorinostat

    Grant number：26861141

    2014.4 - 2016.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    Ogura Ryosuke

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    Grant amount：\3510000 （ Direct Cost: \2700000 、 Indirect Cost：\810000 ）

    Vorinostat, a histone deacetylase inhibitor, suppress O6-methylguanine-DNA methyltransferase (MGMT) activity, but the mechanism is unknown. In this study, we found that it was necessary to resistant to temozolomide that MGMT localized in nucleus. And MGMT overexpression in cytoplasm may be degraded by chaperone-mediated autophagy. It can be new treatment strategy to change MGMT localization by vorinostat.

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