2025/12/30 更新

写真a

イシザキ　フミオ
石崎　文雄
ISHIZAKI Fumio
所属
医歯学総合病院 泌尿器科 助教
職名
助教
外部リンク

学位

  • 博士（医学） （ 2013年3月   新潟大学 ）

経歴（researchmap）

  • 新潟大学医歯学総合病院泌尿器科   助教

    2020年5月 - 現在

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  • 新潟大学医歯学総合病院泌尿器科   特任助教

    2019年5月 - 2020年4月

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経歴

  • 新潟大学   医歯学総合病院 泌尿器科   助教

    2022年4月 - 現在

  • 新潟大学   医歯学総合病院　泌尿器科   特任助教

    2019年5月 - 2022年3月

学歴

  • 新潟大学大学院医歯学総合研究科博士課程

    2009年4月 - 2013年3月

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  • 新潟大学医学部医学科

    1997年4月 - 2003年3月

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所属学協会

▶ 全件表示

 

論文

  • Analysis of dosimetric improvements using hydrogel spacer in high-dose-rate brachytherapy for prostate cancer. 国際誌

    Moe Honda, Tomoya Oshikane, Motoki Kaidu, Eisuke Abe, Takahiro Komiya, Shumpei Yamako, Yukiyo Goto, Hisashi Nakano, Toshimichi Nakano, Satoshi Tanabe, Atsushi Ohta, Satoru Utsunomiya, Nobuko Yamana, Fumio Ishizaki, Hiroyuki Ishikawa

    Journal of contemporary brachytherapy   17 ( 5 )   315 - 321   2025年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: This study primarily aimed to evaluate the effects of a hydrogel spacer (HS) on dosimetric distribution in the planning target volume as well as on rectal and urethral doses in high-dose-rate brachytherapy (HDR-BT) for prostate cancer, and to identify prostate sub-regions with improved dosimetric parameters and patient conditions that particularly benefit from the use of HS. MATERIAL AND METHODS: This study included 28 patients, who underwent HDR-BT using HS. Treatment plans with HS and simulated plans without HS were compared. The prostate was divided into six regions: ventral and dorsal in the dorsoventral direction, and apex, mid-gland, and base in the craniocaudal direction. V100% and D90% were evaluated in each region, along with dose assessments for the rectum and urethra. Paired t-tests were performed to analyze significance, and effect sizes were calculated using Cohen's d. RESULTS: HS significantly improved V100% in the dorsal regions (p < 0.05), particularly in the dorsal apex and dorsal mid regions (median V100% with and without HS: apex, 100.00 vs. 97.10; mid, 100.00 vs. 97.22). D90% showed improvement across all regions (p < 0.05), with greater effects observed in the dorsal apex and dorsal mid regions (median D90% with and without HS: apex, 110.15 vs. 103.56; mid, 113.31 vs. 106.21; d ≥ 0.8). Rectal dose parameters improved significantly (p < 0.05), whereas urethral dose changes were not significant (p = 0.14). CONCLUSIONS: HS effectively reduced rectal doses and improved V100% and D90% in the dorsal apex and dorsal mid regions of the prostate. These regions are anatomically closer to the rectum and are often subject to dose constraints as well as critical areas for sufficient dose delivery because of the frequent localization of prostate cancer lesions. Therefore, HS is particularly beneficial for patients with dominant lesions in these regions.

    DOI： 10.5114/jcb.2025.155737

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  • Late-Onset Bone Metastasis 46 Years After Initial Surgery for Pheochromocytoma: A Case Report. 国際誌

    Fumio Ishizaki, Kaede Hiruma, Yusuke Tani, Hideaki Sugino, Tatsuro Sanami, Tsutomu Anraku, Masahiro Ikeda, Masayuki Tasaki, Kazuhide Saito, Yoshihiko Tomita

    IJU case reports   8 ( 5 )   533 - 538   2025年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    INTRODUCTION: Pheochromocytoma is a rare catecholamine-producing tumor with metastatic potential. Recurrence after more than 40 years is exceptionally rare. CASE PRESENTATION: During evaluation for ischemic colitis, a 71-year-old woman was found to have multiple bone metastases, possibly linked to catecholamine excess. She had undergone left adrenalectomy for pheochromocytoma at age 25. Bone biopsy confirmed metastatic pheochromocytoma, and immunohistochemical findings were similar to the original tumor. Urinary metanephrine and normetanephrine were markedly elevated. She declined systemic therapy and has remained clinically stable for 6 years, with her blood pressure well controlled on doxazosin. CONCLUSION: This case illustrates a recurrence 46 years after adrenalectomy, potentially representing the longest reported interval to date. It highlights the silent and indolent nature of some metastatic pheochromocytomas and underscores the necessity of lifelong follow-up. The patient's stable course also emphasizes the clinical heterogeneity of metastatic pheochromocytoma and supports the need for individualized follow-up and treatment strategies.

    DOI： 10.1002/iju5.70086

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  • Perianal Abscess Caused by Urethral Foreign Body: A Case Report. 国際誌

    Sayaka Hoshino, Kenji Obara, Kazutoshi Yamana, Fumio Ishizaki, Masaki Murata, Tatsuhiko Hoshii, Yoshihiko Tomita

    IJU case reports   8 ( 3 )   249 - 252   2025年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    INTRODUCTION: We report a case of perianal abscess that developed after the presence of a urethral foreign body for 15 months. CASE PRESENTATION: A 14-year-old boy with intellectual disability due to agenesis of the corpus callosum presented to our hospital with complaints of perianal erythema, swelling, and pain. The patient admitted to self-inserting an allene fiber broom ear 15 months ago. A few days after the insertion, he was treated with antibiotics for hematuria and micturition pain. The symptoms resolved spontaneously 2 months later, although the foreign body was not removed. Computed tomography and magnetic resonance imaging demonstrated a perineal linear structure running anterior to posterior. The urethral foreign body was removed by cystourethroscopy and grasper. CONCLUSION: Medical professionals should be aware of the possibility of underlying cognitive and behavioral problems and should be vigilant in screening and treating individuals with refractory lower urinary tract inflammation or hematuria.

    DOI： 10.1002/iju5.70017

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  • Long-term outcomes and prognostic factors of metastatic or recurrent pheochromocytoma and paraganglioma: a 20-year review in a single institution. 国際誌

    Fumio Ishizaki, Takahiro Taguchi, Masaki Murata, Sayaka Hoshino, Tomotaka Toba, Keisuke Takeda, Masayuki Tasaki, Kazutoshi Yamana, Takashi Kasahara, Tatsuhiko Hoshii, Kenji Obara, Kazuhide Saito, Yoshihiko Tomita

    Scientific reports   14 ( 1 )   26456 - 26456   2024年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Pheochromocytoma and paraganglioma (PPGL) represent a group of rare neuroendocrine tumors known for their potential to metastasize. This study provides a comprehensive retrospective evaluation of 15 patients diagnosed with metastatic or recurrent PPGL at our institution over a two-decade span (2000-2020). Our primary objectives were to delineate the long-term clinical outcomes and pinpoint key prognostic determinants. Median duration from initial PPGL diagnosis to the onset of metastasis or recurrence stood at 5.8 years. Predominant sites for metastasis included the bone, lung, lymph nodes, and peritoneum. A salient finding was that surgical interventions targeting metastatic lesions significantly improved prognosis. Further analysis revealed that a Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) exceeding 7 closely associated with unfavorable outcomes. These insights not only underscore the clinical variability of PPGL's progression but also highlight the pivotal role of surgical management for metastatic or recurrent cases. The value of the PASS score as an informative prognostic tool was evident, suggesting its utility in shaping future therapeutic approaches. Given the intricacies of PPGL, collaborative studies involving larger patient cohorts will be crucial to optimize management strategies and prognostication.

    DOI： 10.1038/s41598-024-75354-9

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  • Conversion therapy with pembrolizumab for a peritoneal metastasis of rectal cancer causing hydronephrosis in a patient with Lynch syndrome.

    Akio Matsumoto, Yoshifumi Shimada, Mae Nakano, Hikaru Ozeki, Daisuke Yamai, Masaki Murata, Fumio Ishizaki, Hiromi Nyuzuki, Takeshi Ikeuchi, Toshifumi Wakai

    Clinical journal of gastroenterology   17 ( 3 )   451 - 456   2024年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A 44-year-old woman with Lynch syndrome was referred to our hospital for treatment of recurrence of microsatellite instability-high rectal cancer. [18F]Fluorodeoxyglucose (18FDG)-positron emission tomography revealed a peritoneal metastasis with invasion to the small intestine and left ureter. The peritoneal metastasis was diagnosed initially as unresectable because of extensive invasion to the left ureter requiring nephrectomy. Hence, first-line treatment with pembrolizumab was started. After the first course of pembrolizumab, she developed hydronephrosis and a resulting urinary tract infection (UTI). A percutaneous nephrostomy was performed to control the UTI. After six courses of pembrolizumab, 18FDG-positron emission tomography showed that the peritoneal metastasis was smaller with significantly reduced 18FDG uptake, and it was then diagnosed as resectable without nephrectomy. She underwent R0 resection of the peritoneal metastasis with partial resection of the small intestine. Intraoperatively, the peritoneal metastasis showed no invasion of the left ureter, allowing its preservation. The percutaneous nephrostomy was removed postoperatively, and she has not developed any subsequent UTIs. Histopathologically, the tumor showed a pathological complete response to pembrolizumab. To the best of our knowledge, this is the first case of conversion therapy with pembrolizumab for peritoneal metastasis with hydronephrosis.

    DOI： 10.1007/s12328-024-01931-0

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  • 腎癌に対するIO治療後の腫瘍切除術に関する検討

    田崎 正行, 大橋 瑠子, 風間 明, 晝間 楓, 石崎 文雄, 丸山 亮, 山名 一寿, 冨田 善彦

    腎癌研究会会報   ( 53 )   47 - 47   2023年7月

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    記述言語：日本語   出版者・発行元：(一社)腎癌研究会  

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  • 新潟大学医歯学総合病院における進行性腎細胞癌の一次治療成績

    田崎 正行, 風間 明, 山名 一寿, 丸山 亮, 石崎 文雄, 笠原 隆, 冨田 義彦

    腎癌研究会会報   ( 53 )   97 - 97   2023年7月

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    記述言語：日本語   出版者・発行元：(一社)腎癌研究会  

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  • 腎癌に対するIO治療後の腫瘍切除術に関する検討

    田崎 正行, 大橋 瑠子, 風間 明, 晝間 楓, 石崎 文雄, 丸山 亮, 山名 一寿, 冨田 善彦

    腎癌研究会会報   ( 53 )   47 - 47   2023年7月

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    記述言語：日本語   出版者・発行元：(一社)腎癌研究会  

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  • 新潟大学医歯学総合病院における進行性腎細胞癌の一次治療成績

    田崎 正行, 風間 明, 山名 一寿, 丸山 亮, 石崎 文雄, 笠原 隆, 冨田 義彦

    腎癌研究会会報   ( 52 )   44 - 44   2022年7月

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    記述言語：日本語   出版者・発行元：(一社)腎癌研究会  

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  • A comparative study of high-dose-rate brachytherapy boost combined with external beam radiation therapy versus external beam radiation therapy alone for high-risk prostate cancer. 国際誌

    Tomoya Oshikane, Motoki Kaidu, Eisuke Abe, Atsushi Ohta, Hirotake Saito, Toshimichi Nakano, Moe Honda, Satoshi Tanabe, Satoru Utsunomiya, Ryuta Sasamoto, Fumio Ishizaki, Takashi Kasahara, Tsutomu Nishiyama, Yoshihiko Tomita, Hidefumi Aoyama, Hiroyuki Ishikawa

    Journal of radiation research   62 ( 3 )   525 - 532   2021年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We aimed to compare the outcomes of high-dose-rate brachytherapy (HDR-BT) boost and external beam radiation therapy (EBRT) alone for high-risk prostate cancer. This was a single-center, retrospective and observational study. Consecutive patients who underwent initial radical treatment by HDR-BT boost or EBRT alone from June 2009 to May 2016 at the Niigata University Medical and Dental Hospital, Japan were included. A total of 96 patients underwent HDR-BT boost, and 61 underwent EBRT alone. The prescription dose of HDR-BT boost was set to 18 Gy twice a day with EBRT 39 Gy/13 fractions. The dose for EBRT alone was mostly 70 Gy/28 fractions. The high-risk group received >6 months of prior androgen deprivation therapy. Overall survival, biochemical-free survival, local control and distant metastasis-free survival rates at 5 years were analyzed. The incidence of urological and gastrointestinal late adverse events of Grade 2 and above was also summarized. In the National Comprehensive Cancer Network (NCCN) high-risk calssification, HDR-BT boost had a significantly higher biochemical-free survival rate at 5 years (98.9% versus 90.7%, P = 0.04). Urethral strictures were more common in the HDR-BT boost group. We will continuously observe the progress of the study patients and determine the longer term results.

    DOI： 10.1093/jrr/rrab006

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  • Significance of PSA Screening in Niigata, Japan: Survey of Actual Status of New Cases of Prostate Cancer. 国際誌

    Toshihiro Saito, Shuichi Komatsubara, Noboru Hara, Tsutomu Nishiyama, Akiyoshi Katagiri, Fumio Ishizaki, Akihiko Hatano, Takeshi Komeyama, Shugo Hanyu, Masahiro Terunuma, Tomoyuki Imai, Hideto Go, Hiroaki Iida, Shigenori Kurumada, Shunsuke Yamaguchi, Keisuke Takeda, Takashi Ando, Tatsuhiko Hoshii, Takashi Kasahara, Yoshihiko Tomita

    Research and reports in urology   13   859 - 866   2021年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: This study aims to investigate the utility of prostate-specific antigen (PSA) screening by conducting an all-case survey of newly diagnosed prostate cancer patients at Niigata Prefecture, Japan. PATIENTS AND METHODS: Depending on whether patients were subjected to screening, information was prospectively collected on all prostate cancer patients newly diagnosed between October 1, 2019, and September 30, 2020, at all institutions in Niigata Prefecture where urologists performing prostate biopsy routinely work and differences in clinical parameters were investigated. RESULTS: PSA was measured in 478 out of 1332 patients (35.8%) as part of a community health screening. The rate of metastatic carcinoma (M1) in all patients was 14.9%. When patients were divided into three categories of population-based screening (community health screening and workplace health screening), opportunistic screening (PSA measurements at complete medical check-ups or on patient request), and testing triggered by clinical symptoms or findings, the proportion of metastatic cancer was 4.5%, 3.7%, and 30.6%, respectively, demonstrating that the number of distant metastases was significantly lesser in all patients who underwent screening. CONCLUSION: The one-year all-case survey of newly diagnosed prostate cancer patients demonstrated that PSA screening significantly contributed to the early diagnosis of current prostate cancer in Japan.

    DOI： 10.2147/RRU.S341347

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  • High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term androgen deprivation therapy for very high-risk prostate cancer 国際誌

    Takashi Kasahara, Fumio Ishizaki, Akira Kazama, Eri Yuki, Kazutoshi Yamana, Ryo Maruyama, Tomoya Oshikane, Motoki Kaidu, Hidefumi Aoyama, Vladimir Bilim, Tsutomu Nishiyama, Yoshihiko Tomita

    INTERNATIONAL JOURNAL OF UROLOGY   27 ( 9 )   800 - 806   2020年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/iju.14305

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  • Free Tube Graft Urethroplasty for Repair of Hypospadias 国際誌

    Kenji Obara, Tatsuhiko Hoshii, Sayaka Hoshino, Kazutoshi Yamana, Tsutomu Anraku, Ryo Maruyama, Hiroo Kuroki, Fumio Ishizaki, Hiroyuki Yamazaki, Yoshihiko Tomita

    UROLOGIA INTERNATIONALIS   104 ( 5-6 )   386 - 390   2020年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1159/000504146

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  • Solitary brain metastasis from prostate cancer after multi modality treatment: A case report 国際誌

    Fumio Ishizaki, Ryo Maruyama, Kazutoshi Yamana, Takashi Kasahara, Tsutomu Nishiyamaa, Yoshihiko Tomita

    UROLOGY CASE REPORTS   24   100879 - 100879   2019年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.eucr.2019.100879

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  • Low-Dose-Rate and High-Dose-Rate Brachytherapy for Localized Prostate Cancer in ABO-Incompatible Renal Transplant Recipients. 国際誌

    M Tasaki, T Kasahara, M Kaidu, G Kawaguchi, N Hara, K Yamana, R Maruyama, I Takizawa, F Ishizaki, K Saito, Y Nakagawa, M Ikeda, H Umezu, T Nishiyama, H Aoyama, Y Tomita

    Transplantation proceedings   51 ( 3 )   774 - 778   2019年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Brachytherapy is one of the standard treatments for localized prostate cancer (CaP). However, the feasibility of brachytherapy for renal transplant recipients (RTRs) is still uncertain. MATERIALS AND METHODS: Between August 2007 and March 2018, all patients who had undergone low-dose-rate (LDR) brachytherapy or high-dose-rate (HDR) brachytherapy for clinically localized CaP at our institution were retrospectively identified (n = 394). Of these patients, 3 had a history of renal transplantation. We reviewed all available clinical data retrospectively. RESULTS: All of the RTRs received ABO-incompatible renal grafts from their spouses and had stable renal graft function before the diagnosis of CaP. The median age at diagnosis of CaP was 65 years (range, 60-67 years). The median time between transplantation and brachytherapy was 7 years (range, 4-10 years). In all of the patients, clinical stage was cT1cN0M0. Two patients received 125I LDR-brachytherapy (dose, 145 Gy) and 1 patient was treated by 192Ir HDR brachytherapy (dose, 19 Gy in 2 fractions) combined with external beam radiation therapy of 39 Gy in 13 fractions. The median follow-up period after brachytherapy was 44 months (range, 34-50 months). During the follow-up period, none of the patients developed disease progression including biochemical recurrence or clinically significant adverse events associated with radiation therapy. CONCLUSIONS: LDR brachytherapy and HDR brachytherapy are safe and technically feasible in RTRs with CaP, and oncological outcomes in RTRs do not appear to be inferior to those of patients who did not receive renal transplant.

    DOI： 10.1016/j.transproceed.2018.10.027

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  • A case of normotensive incidentally discovered adrenal pheochromocytoma 国際誌

    Nobumasa Ohara, Masanori Kaneko, Yuta Yaguchi, Hajime Ishiguro, Fumio Ishizaki, Ryo Maruyama, Kazuya Suzuki, Takeshi Komeyama, Hiroyuki Usuda, Yuto Yamazaki, Hironobu Sasano, Kenzo Kaneko, Kyuzi Kamoi

    CLINICAL CASE REPORTS   6 ( 12 )   2303 - 2308   2018年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/ccr3.1772

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  • Lung adenocarcinoma and adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 国際誌

    Nobumasa Ohara, Masanori Kaneko, Masahiro Ikeda, Fumio Ishizaki, Kazuya Suzuki, Ryo Maruyama, Takeshi Komeyama, Kazuhiro Sato, Kenichi Togashi, Hiroyuki Usuda, Yuto Yamazaki, Hironobu Sasano, Kenzo Kaneko, Kyuzi Kamoi

    RESPIRATORY MEDICINE CASE REPORTS   20   77 - 81   2017年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.rmcr.2016.12.002

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  • Dihydrotestosterone synthesis pathways from inactive androgen 5 alpha-androstane-3 beta, 17 beta-diol in prostate cancer cells: Inhibition of intratumoural 3 beta-hydroxysteroid dehydrogenase activities by abiraterone 国際誌

    Takashi Ando, Tsutomu Nishiyama, Itsuhiro Takizawa, Fumio Ishizaki, Yoshimichi Miyashiro, Keisuke Takeda, Noboru Hara, Yoshihiko Tomita

    SCIENTIFIC REPORTS   6   32198 - 32198   2016年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep32198

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  • Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen 国際誌

    Keisuke Takeda, Noboru Hara, Tsutomu Nishiyama, Masayuki Tasaki, Fumio Ishizaki, Yoshihiko Tomita

    BMC CANCER   16   332 - 332   2016年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1186/s12885-016-2378-y

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  • BLOCKING THE INTRACRINE BACK-CONVERSION PATHWAY WITH ABIRATERONE IN PROSTATE CANCER CELLS

    Takashi Ando, Itsuhiro Takizawa, Fumio Ishizaki, Keisuke Takeda, Yoshimichi Miyashiro, Noboru Hara, Tsutomu Nishiyama

    JOURNAL OF UROLOGY   193 ( 4 )   E678 - E679   2015年4月

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  • EFFECT OF DUTASTERIDE ON INTRAPROSTATIC LEVELS OF ESTROGENS AND ANDROGENS IN MEN WITH BENIGN PROSTATIC HYPERPLASIA

    Itsuhiro Takizawa, Fumio Ishizaki, Yoshimichi Miyashiro, Takeshi Komeyama, Hideo Morishita, Tsutomu Nishiyama

    JOURNAL OF UROLOGY   193 ( 4 )   E358 - E358   2015年4月

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  • IMPACT OF LAPAROSCOPIC NEPHRECTOMY ON HEALTH RELATED QUALITY OF LIFE: COMPARISON BETWEEN RENAL CANCER PATIENTS AND HEALTHY KIDNEY DONORS.

    Takashi Kasahara, Shuichi Komatsu, Fumio Ishizaki, Tsutomu Nishiyama, Kota Takahashi

    JOURNAL OF UROLOGY   189 ( 4 )   E182 - E183   2013年4月

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  • ANDROGEN DEPRIVATION PROMOTES INTRATUMORAL SYNTHESIS OF DIHYDROTESTOSTERONE FROM ANDROGEN METABOLITES IN PROSTATE CANCER 国際誌

    Fumio Ishizaki, Tsutomu Nishiyama, Takashi Kawasaki, Yoshimichi Miyashiro, Noboru Hara, Itsuhiro Takizawa, Makoto Naito, Kota Takahashi

    JOURNAL OF UROLOGY   189 ( 4 )   E134 - E134   2013年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.juro.2013.02.1716

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  • Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer

    Fumio Ishizaki, Tsutomu Nishiyama, Takashi Kawasaki, Yoshimichi Miyashiro, Noboru Hara, Itsuhiro Takizawa, Makoto Naito, Kota Takahashi

    SCIENTIFIC REPORTS   3   2013年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep01528

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  • Decrease in Lean Body Mass in Men With Prostate Cancer Receiving Androgen Deprivation Therapy: Mechanism and Biomarkers 国際誌

    Noboru Hara, Fumio Ishizaki, Toshihiro Saito, Tsutomu Nishiyama, Takashi Kawasaki, Kota Takahashi

    UROLOGY   81 ( 2 )   376 - 380   2013年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.urology.2012.10.050

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  • IMPACT OF LAPAROSCOPIC NEPHRECTOMY ON HRQOL: COMPARISON BETWEEN RENAL CANCER PATIENTS AND HEALTHY KIDNEY DONORS

    Takashi Kasahara, Shuichi Komatsu, Tsutomu Nishiyama, Fumio Ishizaki, Kota Takahashi

    JOURNAL OF ENDOUROLOGY   26   A429 - A429   2012年9月

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    記述言語：英語  

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  • Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer 国際誌

    Noboru Hara, Itsuhiro Takizawa, Etsuko Isahaya, Tsutomu Nishiyama, Tatsuhiko Hoshii, Fumio Ishizaki, Kota Takahashi

    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS   30 ( 5 )   596 - 601   2012年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.urolonc.2010.11.001

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  • Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy 国際誌

    Shuichi Komatsu, Noboru Hara, Fumio Ishizaki, Tsutomu Nishiyama, Itsuhiro Takizawa, Etsuko Isahaya, Takashi Kawasaki, Kota Takahashi

    PROSTATE   72 ( 11 )   1207 - 1213   2012年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/pros.22471

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  • Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancer

    Fumio Ishizaki, Noboru Hara, Itsuhiro Takizawa, Tsutomu Nishiyama, Etsuko Isahaya, Takashi Kawasaki, Kota Takahashi

    GROWTH HORMONE & IGF RESEARCH   22 ( 3-4 )   122 - 128   2012年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.ghir.2012.04.003

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  • Prediction of pathological and oncological outcomes based on extended prostate biopsy results in patients with prostate cancer receiving radical prostatectomy: a single institution study 国際誌

    Fumio Ishizaki, Noboru Hara, Hiroshi Koike, Makoto Kawaguchi, Akira Tadokoro, Itsuhiro Takizawa, Tsutomu Nishiyama, Kota Takahashi, Rudolf Hohenfellner

    DIAGNOSTIC PATHOLOGY   7   68 - 68   2012年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1186/1746-1596-7-68

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  • Intratumoral dihydrotestosterone regulation by conversion of androstanediol to dihydrotestosterone in prostate cancer

    Fumio Ishizaki, Tsutomu Nishiyama, Takashi Kawasaki, Noboru Hara, Yoshimichi Miyashiro, Itsuhiro Takizawa, Makoto Naito, Kota Takahashi

    CANCER RESEARCH   72   2012年4月

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  • THE TRANSCRIPTOMICS OF INTRATUMORAL ANDROGEN BIOSYNTHESIS FROM ADRENAL ANDROGEN IN PROSTATE CANCER CELLS FOLLOWING ANDROGEN DEPRIVATION: ESTABLISHMENT OF CASTRATION-RESISTANT MODEL

    Fumio Ishizaki, Tsutomu Nishiyama, Noboru Hara, Kota Takahashi

    JOURNAL OF UROLOGY   187 ( 4 )   E198 - E198   2012年4月

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  • UNAFFECTED INTERLEUKIN-6 LEVEL DESPITE INCREASED BODY FAT DURING ANDROGEN DEPRIVATION THERAPY (ADT): COORDINATE REGULATION BETWEEN SEX STEROIDS AND INTERLEUKIN-6 IS ASSOCIATED WITH ADT-RELATED BODY COMPOSITION CHANGE

    Noboru Hara, Fumio Ishizaki, Tsutomu Nishiyama, Kota Takahashi

    JOURNAL OF UROLOGY   187 ( 4 )   E310 - E310   2012年4月

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  • External Validation of the UCSF-CAPRA (University of California, San Francisco, Cancer of the Prostate Risk Assessment) in Japanese Patients Receiving Radical Prostatectomy 国際誌

    Fumio Ishizaki, Md. Aminul Hoque, Tsutomu Nishiyama, Takashi Kawasaki, Takashi Kasahara, Noboru Hara, Itsuhiro Takizawa, Toshihiro Saito, Yasuo Kitamura, Kohei Akazawa, Kota Takahashi

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   41 ( 11 )   1259 - 1264   2011年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/jjco/hyr136

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  • ALTERED ACTIVITY IN EACH PITUITARY-GONADAL, PITUITARY-ADRENAL, AND GH/IGF-1 ENDOCRINE AXIS IS ASSOCIATED WITH BONE METABOLIC DISORDER IN PATIENTS WITH PROSTATE CANCER RECEIVING ANDROGEN DEPRIVATION THERAPY

    Fumio Ishizaki, Noboru Hara, Tsutomu Nishiyama, Etsuko Isahaya, Itsuhiro Takizawa, Tatsuhiko Hoshii, Kota Takahashi

    JOURNAL OF UROLOGY   185 ( 4 )   E446 - E447   2011年4月

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  • 5 alpha- ANDROSTANE-3 alpha 17 beta-DIOL WILL BE A POTENTIAL PRECURSOR OF THE MOST ACTIVE ANDROGEN 5 alpha- DIHYDROTESTOSTERONE IN PROSTATE CANCER

    Tsutomu Nishiyama, Fumio Ishizaki, Itsuhiro Takizawa, Kazutoshi Yamana, Noboru Hara, Kota Takahashi

    JOURNAL OF UROLOGY   185 ( 4 )   E116 - E116   2011年4月

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  • Trilostane, an inhibitor of 3 beta-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells 国際誌

    Itsuhiro Takizawa, Tsutomu Nishiyama, Noboru Hara, Tatsuhiko Hoshii, Fumio Ishizaki, Yoshimichi Miyashiro, Kota Takahashi

    CANCER LETTERS   297 ( 2 )   226 - 230   2010年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.canlet.2010.05.015

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  • [Inverted papilloma of the prostatic urethra: a report of two cases].

    Fumio Ishizaki, Syugo Hanyu

    Hinyokika kiyo. Acta urologica Japonica   54 ( 2 )   143 - 5   2008年2月

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

    Two men with inverted papilloma of the prostatic urethra are reported. Case 1 was a 67-year-old man with complaints of gross hematuria and urinary retention. Urethroscopy revealed a smooth-surface tumor with a stalk at the prostatic urethra. Case 2 was a 76-year-old man with complaints of gross hematuria and urinary retention. In these cases, the tumors were resected transurethrally and were consistent with inverted papilloma histopathologically.

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  • The influence of androgen deprivation therapy on metabolism in patients with prostate cancer. 国際誌

    Tsutomu Nishiyama, Fumio Ishizaki, Tsutomu Anraku, Hisanobu Shimura, Kota Takahashi

    The Journal of clinical endocrinology and metabolism   90 ( 2 )   657 - 60   2005年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The effects of androgen deprivation therapy (ADT) include not only suppression of tumor growth, but also adverse effects on various bodily functions. The aim of this study was to determine the metabolic effects of ADT in patients with nonmetastatic prostate cancer. Forty-nine men with prostate cancer were treated with ADT before beginning radical therapy for 6 months. Body weight, peripheral red blood cell counts, hemoglobin, hematocrit, fasting blood sugar, serum total cholesterol, blood urea nitrogen, uric acid, compensated calcium, inorganic phosphorus, bone-specific alkaline phosphatase, urinary deoxypyridinoline, and radial bone density determined using dual energy x-ray absorptiometry were examined before and 6 months after ADT treatment. Body weight (P = 0.037) and the levels of fasting blood sugar (P = 0.014), serum total cholesterol (P = 0.017), blood urea nitrogen (P = 0.030), compensated calcium (P < 0.001), inorganic phosphorus (P < 0.001), bone-specific alkaline phosphatase (P < 0.001), and compensated urinary deoxypyridinoline (P < 0.001) increased significantly. Peripheral red blood cell counts (P < 0.001), hemoglobin level (P < 0.001), hematocrit (P < 0.001), uric acid (P < 0.001), and radial bone density (P = 0.023) decreased significantly. These effects of ADT on various bodily functions warrant systematic study in clinical trials. We should be aware of the far-reaching consequences of ADT and incorporate strategies for preventing and managing adverse effects into routine practice.

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  • Development of a novel monoclonal antibody recognizing basal cells of human squamous epithelia.

    Jiro Hitomi, Fumio Ishizaki, Eiji Kimura, Nobuyuki Sato

    Archives of histology and cytology   65 ( 2 )   201 - 8   2002年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The basal layer of the epithelium is usually thought to contain stem or progenitor cell populations. In order to analyze its biological characteristics, we attempted to produce novel monoclonal antibodies recognizing basal cells of the human esophageal epithelium. Hybridomas were generated from fusions between spleen cells of ddY mice immunized with esophageal epithelial cells (EECs) cultured at low calcium concentrations. A clone, NJ-E-H10, producing a monoclonal antibody (moAb) reacting with basal cells of human esophageal epithelia, was selected for its staining pattern on frozen sections of the epithelia. The immunoreactivities of NJ-E-H10 were detected in the cytoplasm of basal cells predominantly located in the interpapillary zones of the epithelia. In the primary culture of EECs, immunoreactive cells were present at the marginal area of the growing colonies, where EECs extend their cytoplasm and migrate out of the colonies. Immunoelectron microscopy demonstrated the immunoreactivities of the moAb NJ-E-H10 around the intermediate filaments of basal cells, but not on the filaments themselves. In the human skin, NJ-E-H10 positive cells were also observed in the basal layer of the epidermis as well as in keratinocytes in the outer layer of the outer root sheath in hair follicles and myoepitheial cells in the sweat glands. Since the distribution of NJ-E-H10 immunoreactivities differs from that reported by hitherto-known antibodies, the MoAb NJ-E-H10 is considered a new marker for clarifing the biological properties of the basal cell compartment in stratified epithelia.

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MISC

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受賞

  • 研究助成優秀テーマ

    2012年   AKUA（Asahi Kasei pharma Urological Academy）  

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  • 優秀演題賞

    2011年   日本癌治療学会  

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  • 新潟大学若手医学研究賞

    2010年   新潟大学医学部  

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共同研究・競争的資金等の研究

  • 前立腺組織内アンドロゲン環境の変化に適応したアンドロゲン受容体活性化機構の解明

    研究課題/領域番号：15K20075

    2015年4月 - 2017年3月

    制度名：科学研究費助成事業 若手研究(B)

    研究種目：若手研究(B)

    提供機関：日本学術振興会

    瀧澤 逸大, 安藤 嵩, 宮代 好通, 石崎 文雄, 西山 勉, 冨田 善彦

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    配分額：3900000円 （ 直接経費：3000000円 、 間接経費：900000円 ）

    低アンドロゲン環境下に適応した前立腺癌アンドロゲン受容体活性化機構の解明を目的とした。5α還元酵素阻害剤、デュタステリドの投与群、非投与群の前立腺癌組織内ステロイド濃度を測定し、21炭素ステロイドである20β-OHDHPに着目した。20β-OHDHPは野生型および変異型前立腺癌細胞株のアンドロゲン受容体を活性化し、細胞増殖を促進することが明らかとなった。20β-OHDHPの合成経路は去勢抵抗性前立腺癌の治療標的となりうることが示唆された。

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