2021/10/25 更新

写真a

シマモト サキ
島元 紗希
SHIMAMOTO Saki
所属
教育研究院 自然科学系 農学系列 助教
農学部 農学科 助教
職名
助教
連絡先
メールアドレス
外部リンク

学位

  • 農学 ( 2019年9月   鹿児島大学 )

研究キーワード

  • 畜産物利用

  • 骨格筋タンパク質分解

  • 飼料化学

  • 栄養生化学

研究分野

  • ライフサイエンス / 応用生物化学

  • ライフサイエンス / 動物生産科学

  • ライフサイエンス / 動物生産科学

経歴(researchmap)

  • 日本学術振興会 特別研究員PD

    2019年10月 - 2020年2月

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  • 日本学術振興会 特別研究員DC1

    2017年4月 - 2019年9月

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経歴

  • 新潟大学   農学部 農学科   助教

    2020年3月 - 現在

学歴

  • 鹿児島大学大学院   連合農学研究科   応用生命科学専攻

    - 2019年9月

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  • 鹿児島大学大学院   農学研究科   生物資源化学専攻

    - 2017年3月

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  • 鹿児島大学   農学部   生物資源化学科

    - 2015年3月

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所属学協会

委員歴

  • 全日本大学対抗ミートジャッジング競技会   実行委員会委員  

    2018年10月 - 現在   

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    団体区分:その他

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論文

  • Impact on genetic differences among various chicken breeds on free amino acid contents of egg yolk and albumen. 国際誌

    Tatsuhiko Goto, Saki Shimamoto, Masahiro Takaya, Shun Sato, Kanna Takahashi, Kenji Nishimura, Yasuko Morii, Kyoko Kunishige, Akira Ohtsuka, Daichi Ijiri

    Scientific reports   11 ( 1 )   2270 - 2270   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Eggs play important roles as food resources and nutraceuticals, to alleviate malnutrition and to improve health status in the world. Since free amino acids contribute to the nutritional values and food tastes, we investigated a total of 81 eggs from five chicken breeds, which are Australorp, Nagoya (NGY), Rhode Island Red (RIR), Shamo (SHA), Ukokkei, and two F1 hybrids (NGYxRIR and SHAxRIR) to test impact on genetic differences in 10 egg traits, 20 yolk amino acid traits, and 18 albumen amino acid traits. One-way ANOVA revealed significant breed effects on 10 egg traits, 20 yolk amino acid traits, and 15 albumen amino acid traits. Moreover, a significant heterosis effect on yolk aspartic acid was identified. In addition, positive correlations were found broadly among traits within each trait category (egg traits, yolk amino acid traits, and albumen amino acid traits), whereas there were basically no or weak correlations among the trait categories. These results suggest that almost all traits can be dramatically modified by genetic factor, and there will be partially independent production systems of amino acids into yolk and albumen. Since there will be typical quantitative genetic architecture of egg contents, further genetic analyses will be needed.

    DOI: 10.1038/s41598-021-81660-3

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  • Analyses of free amino acid and taste sensor traits in egg albumen and yolk revealed potential of value-added eggs in chickens. 国際誌

    Tatsuhiko Goto, Saki Shimamoto, Akira Ohtsuka, Daichi Ijiri

    Animal science journal = Nihon chikusan Gakkaiho   92 ( 1 )   e13510   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To create high-quality eggs by using different breed and feed materials, we investigated free amino acid contents and taste sensor traits using two chicken breeds (Rhode Island Red; RIR and Australorp; AUS) fed two feeds (mixed and fermented feeds). Two-way ANOVA revealed significant breed and feed main and interaction effects on albumen bitterness and a significant interaction effect on yolk bitterness. Albumen from RIR fed mixed feed and AUS fed fermented feed was higher bitterness, whereas yolk from those groups was lower bitterness. Significant breed effects were detected in four albumen amino acid traits (His, Met, Ile, and Lys) and a yolk His, whereas significant feed effects were found in 15 albumen amino acid traits (Asp, Glu, Ser, His, Gly, Thr, Ala, Tyr, Val, Met, Trp, Ile, Leu, Lys, and Pro) and a yolk cystine trait. Compared to albumen amino acids, yolk amino acids had limited effects by breed and feed. The present results suggest that genetic and nutritional factors can alter not only amino acid contents but also sensor values of bitterness, indicating that selecting the combination of breed and feed enable us to make amino acids enriched and taste added designer eggs in future.

    DOI: 10.1111/asj.13510

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  • Insulin Stimulation of Protein Synthesis and mTOR Signaling in Chick Myotube Cultures. 査読

    Kazuki Nakashima, Aiko Ishida, Saki Shimamoto, Daichi Ijiri, Akira Ohtsuka

    The journal of poultry science   57 ( 3 )   205 - 209   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Poultry Science Association  

    Insulin stimulates protein synthesis in skeletal muscles. Protein synthesis is controlled by the mechanistic target of rapamycin (mTOR) signaling in skeletal muscles. This study was conducted to investigate the effect of insulin on protein synthesis and mTOR signaling in chick myotube cultures. Chick myotubes were incubated with insulin (1 µg/ml) for 1 h. Protein synthesis, measured using the surface sensing of translation method, was significantly increased by insulin. The phosphorylation of AKT (Thr308 and Ser473), p70 ribosomal S6 kinase 1 (S6K1, Thr389), S6 ribosomal protein (Ser235/236), and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1, Thr37/46) was also significantly increased by insulin. These results suggest that insulin stimulates protein synthesis via mTOR signaling (phosphorylation of AKT, S6K1, S6 ribosomal protein, and 4E-BP1) in chick myotube cultures.

    DOI: 10.2141/jpsa.0190082

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  • Effects of Cyclic High Ambient Temperature and Dietary Supplementation of Orotic Acid, a Pyrimidine Precursor, on Plasma and Muscle Metabolites in Broiler Chickens. 査読 国際誌

    Saki Shimamoto, Kiriko Nakamura, Shozo Tomonaga, Satoru Furukawa, Akira Ohtsuka, Daichi Ijiri

    Metabolites   10 ( 5 )   2020年5月

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    記述言語:英語  

    The aim of this study was to evaluate the effects of high ambient temperature (HT) and orotic acid supplementation on the plasma and muscle metabolomic profiles in broiler chickens. Thirty-two 14-day-old broiler chickens were divided into four treatment groups that were fed diets with or without 0.7% orotic acid under thermoneutral (25 ± 1 °C) or cyclic HT (35 ± 1 °C for 8 h/day) conditions for 2 weeks. The chickens exposed to HT had higher plasma malondialdehyde concentrations, suggesting an increase in lipid peroxidation, which is alleviated by orotic acid supplementation. The HT environment also affected the serine, glutamine, and tyrosine plasma concentrations, while orotic acid supplementation affected the aspartic acid, glutamic acid, and tyrosine plasma concentrations. Untargeted gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS)-based metabolomics analysis identified that the HT affected the plasma levels of metabolites involved in purine metabolism, ammonia recycling, pyrimidine metabolism, homocysteine degradation, glutamate metabolism, urea cycle, β-alanine metabolism, glycine and serine metabolism, and aspartate metabolism, while orotic acid supplementation affected metabolites involved in pyrimidine metabolism, β-alanine metabolism, the malate-aspartate shuttle, and aspartate metabolism. Our results suggest that cyclic HT affects various metabolic processes in broiler chickens, and that orotic acid supplementation ameliorates HT-induced increases in lipid peroxidation.

    DOI: 10.3390/metabo10050189

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  • Feeding the outer bran fraction of rice alters hepatic carbohydrate metabolism in rats. 査読

    Kawaguchi M, Nishikoba N, Shimamoto S, Tomonaga S, Kohrogi R, Yamauchi Y, Fujita Y, Ohtsuka A, Ijiri D

    Nutrients   12 ( 2 )   430   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/nu12020430

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  • Effects of delaying post-hatch feeding on lipid peroxidation and antioxidant enzyme mRNA expression in the pectoralis major muscle of newly hatched chicks. 査読

    Rukana Kohrogi, Saki Shimamoto, Kazuki Nakashima, Daichi Sonoda, Akira Ohtsuka, Daichi Ijiri

    Animal Science Journal   91   e13327   2020年1月

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  • Insulin acutely increases glucose transporter 1 on plasma membranes and glucose uptake in an AKT-dependent manner in chicken adipocytes. 査読

    Shimamoto S, Nakashima K, Kamimura R, Kohrogi R, Inoue H, Nishikoba N, Ohtsuka A, Ijiri D

    General and Comparative Endocrinology   283   113232   2019年11月

  • レイヤー初生ヒナへの飼料給与開始の遅延が適温および暑熱環境下での産卵成績と卵質に及ぼす影響

    興梠瑠香奈, 西木場菜央, 島元紗希, 上村凌, 中島一喜, 多田司, 大塚彰, 井尻大地

    日本家禽学会誌   56 ( J1 )   J1‐J6   2019年4月

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  • Effects of astaxanthin-rich dried cell powder from Paracoccus carotinifaciens on carotenoid composition and lipid peroxidation in skeletal muscle of broiler chickens under thermo-neutral or realistic high temperature conditions. 査読

    Inoue H, Shimamoto S, Takahashi H, Kawashima Y, Wataru S, Ijiri D, Ohtsuka A

    Animal Science Journal = Nihon chikusan Gakkaiho   90 ( 2 )   229 - 236   2019年2月

  • The β<sub>2</sub>-adrenergic receptor is involved in differences in the protein degradation level of the pectoral muscle between fast- and slow-growing chicks during the neonatal period. 査読

    Shimamoto S, Ijiri D, Nakashima K, Kawaguchi M, Ohtsuka A

    General and Comparative Endocrinology   267   45 - 50   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ygcen.2018.05.028

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  • ブロイラー初生ヒナへの飼料給与の開始日齢が鶏肉の脂質過酸化,ドリップ量,肉色,低分子代謝産物濃度,および味認識装置により測定された味覚特性に及ぼす影響

    井尻大地, 宝蔵直樹, 島元紗希, 川口真奈, 古川愛理, 多田司, 友永省三, 中島一喜, 大塚彰

    日本畜産学会報   89 ( 2 )   191‐198(J‐STAGE)   2018年

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    記述言語:日本語  

    DOI: 10.2508/chikusan.89.191

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  • β<sub>1</sub>- and β<sub>2</sub>-adrenergic receptor stimulation differ in their effects on PGC-1α and atrogin-1/MAFbx gene expression in chick skeletal muscle. 査読

    Shimamoto S, Ijiri D, Kawaguchi M, Nakashima K, Tada O, Inoue H, Ohtsuka A

    Comparative Biochemistry and Physiology. Part A, Molecular & integrative physiology   211   1 - 6   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cbpa.2017.05.013

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  • Effects of Insulin-Like Growth Factor-I on the Expression of Atrogin-1/MAFbx in Chick Myotube Cultures 査読

    Kazuki Nakashima, Aiko Ishida, Saki Shimamoto, Daichi Ijiri, Akira Ohtsuka

    JOURNAL OF POULTRY SCIENCE   54 ( 3 )   247 - 252   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN POULTRY SCIENCE ASSOC  

    The expression of atrogin-1/MAFbx, a muscle-specific E3 ubiquitin ligase, is increased in catabolic conditions that result in muscle atrophy. The expression of atrogin-1/MAFbx mRNA is also decreased by the insulin-like growth factor-I (IGF-I) in mammalian skeletal muscle cell cultures. This study investigated the effect of IGF-I on the expression of atrogin-1/MAFbx in chicken skeletal muscle cell cultures. Chick myotubes were incubated with IGF-I for 1, 6, or 24 h. Protein content was increased by IGF-I (100 ng/ml) and incubated for 24 h in chick myotubes. The expression of atrogin-1/MAFbx mRNA decreased in the presence of IGF-I (1, 10, and 100 ng/ml) for 6h in chick myotubes. The expression of the m-calpain large subunit and cathepsin B mRNA was not decreased by IGF-I. Phosphorylation of Akt and FOXO1 increased in the presence of IGF-I (100 ng/ml) for 1 h in chick myotubes. These results indicate that IGF-I suppresses atrogin-1/MAFbx mRNA expression by phosphorylation of Akt and FOXO1, resulting in an increase in muscle growth in chick myotube cultures.

    DOI: 10.2141/jpsa.0160141

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  • Effects of first exogenous nutrients on the mRNA levels of atrogin-1/MAFbx and GLUT1 in the skeletal muscles of newly hatched chicks 査読

    Daichi Ijiri, Said Shimamoto, Mana Kawaguchi, Airi Furukawa, Kazuki Nakashima, Osamu Tada, Akira Ohtsuka

    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY   205   8 - 14   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    The aim of this study was to examine the effects of first exogenous nutrients on the mRNA levels of muscle atrophy F-box (atrogin-1/MAFbx) and glucose transporters (GLUTs) in the skeletal muscles of newly hatched chicks with no feed experience. In experiment 1, newly hatched chicks had free access to feed or were fasted for the first 24 h. The chicks having free access to feed for the first 24 h increased their body weight and had decreased atrogin-1/MAFbx mRNA levels in their sartorius and pectoralis major muscles compared with the fasted chicks. In experiment 2, newly hatched chicks received a single feed via intubation into the crop. Three hours after intubation, levels of atrogin-1/MAFbx mRNA in the sartorius muscle were decreased whereas the plasma insulin concentration and phosphorylated Ala levels in the sartorius muscle were increased. In addition, the mRNA levels of GLUT1 and GLUT8 were increased in the-sartorius muscle after the intubation. However, in the pectoralis major muscle, ART phosphorylation and levels of atrogin-1/MAFbx, GLUT1 and GLUT8 mRNA were not affected 3 h after intubation. The first exogenous nutrients increased the level of phosphorylated ART in the sartorius muscle of newly hatched chicks, possibly because of the decrease in atrogin-1/MAFbx mRNA levels. Furthermore, the sartorius muscle in newly hatched chicks appeared to be more susceptible to the first feed compared with the pectoralis major muscle.(C) 2016 Published by Elsevier Inc.

    DOI: 10.1016/j.cbpa.2016.12.014

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  • Single injection of clenbuterol into newly hatched chicks decreases abdominal fat pad weight in growing broiler chickens 査読

    Daichi Ijiri, Kanae Ishitani, Mahmoud Mohamed Hamza El-Deep, Mana Kawaguchi, Saki Shimamoto, Yoshitaka Ishimaru, Akira Ohtsuka

    ANIMAL SCIENCE JOURNAL   87 ( 10 )   1298 - 1303   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    The aim of the current study was to examine the effects of clenbuterol injection into newly hatched chicks on both the abdominal fat pad tissue weight and the skeletal muscle weight during subsequent growth. Twenty-seven 1-day-old chicks were divided into two groups, receiving either a single intraperitoneal (i.p.) injection of clenbuterol (0.1mg/kg body weight) or phosphate-buffered saline (PBS). Body weight gain, feed intake and feed conversion ratio were not affected by clenbuterol injection during the 5-week experimental period, while the abdominal fat pad tissue weight of the clenbuterol-injected chicks was lower than that of the control chicks at 5 weeks post-injection. Plasma non-esterified fatty acid concentrations were significantly increased in the clenbuterol-injected chicks, while plasma triacylglycerol concentrations did not differ. Additionally, the enzymatic activity of fatty acid synthase was lower in the liver of the clenbuterol-injected chicks. Conversely, the skeletal muscle weights were not affected by clenbuterol injection. These results suggest that a single clenbuterol injection into 1-day-old chicks decreases the abdominal fat pad tissue weight, but may not affect skeletal muscle weights during growth.

    DOI: 10.1111/asj.12541

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  • Clenbuterol changes phosphorylated FOXO1 localization and decreases protein degradation in the sartorius muscle of neonatal chicks 査読

    Saki Shimamoto, Daichi Ijiri, Kazuki Nakashima, Mana Kawaguchi, Yoshitaka Ishimaru, Airi Furukawa, Akira Ohtsuka

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   80 ( 8 )   1499 - 1504   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    To investigate the intracellular signaling mechanisms by which clenbuterol reduces muscle protein degradation, we examined the phosphorylation level and intracellular localization of FOXO1 in the sartorius muscle of neonatal chicks. One-day-old chicks were given a single intraperitoneal injection of clenbuterol (0.1mg/kg body weight). Three hours after injection, AKT protein was phosphorylated in the sartorius muscle by clenbuterol injection. Coincidentally, clenbuterol increased cytosolic level of phosphorylated FOXO1 protein, while it decreased nuclear level of FOXO1 protein in the sartorius muscle. Furthermore, clenbuterol decreased the expression of mRNAs for muscle-specific ubiquitin ligases (atrogin-1/MAFbx and MuRF1) in the sartorius muscle accompanied by decreased plasma 3-methylhistidine concentration, an index of muscle protein degradation, at 3h after injection. These results suggested that, in the sartorius muscle of the chicks, clenbuterol changed the intracellular localization of phosphorylated FOXO1, and consequently decreased protein degradation via suppressing the expression of genes encoding muscle-specific ubiquitin ligases.

    DOI: 10.1080/09168451.2016.1158629

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  • Gene expression pattern of glucose transporters in the skeletal muscles of newly hatched chicks 査読

    Saki Shimamoto, Daichi Ijiri, Mana Kawaguchi, Kazuki Nakashima, Akira Ohtsuka

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   80 ( 7 )   1382 - 1385   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    The gene expression pattern of the glucose transporters (GLUT1, GLUT3, GLUT8, and GLUT12) among pectoralis major and minor, biceps femoris, and sartorius muscles from newly hatched chicks was examined. GLUT1 mRNA level was higher in pectoralis major muscle than in the other muscles. Phosphorylated AKT level was also high in the same muscle, suggesting a relationship between AKT and GLUT1 expression.

    DOI: 10.1080/09168451.2016.1162088

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  • The effects of acute cold exposure on morphology and gene expression in the heart of neonatal chicks 査読

    Tomoko Matsubara, Saki Shimamoto, Daichi Ijiri, Akira Ohtsuka, Yukio Kanai, Miho Hirabayashi

    JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY   186 ( 3 )   363 - 372   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER HEIDELBERG  

    Cold exposure induces an increase in blood flow and blood pressure, and long-term exposure to cold causes cardiac hypertrophy. Neonatal chicks (Gallus gallus domesticus) are highly sensitive to cold exposure, because their capacity for thermogenesis is immature until 1 week after hatching. Hence, we hypothesized that the heart of chicks at around 1 week of age acutely responds to cold environment. To investigate the effect of acute (24 h) and long-term (2 weeks) cold on the heart of chicks, 7-day-old chicks were exposed to cold temperature (4 A degrees C) or kept warm (30 A degrees C). Chicks exposed to the cold showed cardiac hypertrophy with marked left ventricular (LV) chamber dilation and wall thickening. On the other hand, long-term cold exposure (2 weeks from 7-day-old) induced an increase in total ventricular mass, but not in LV morphological parameters. Then, we investigated the details of acute cardiac hypertrophy in chicks. Electron microscopy revealed that cardiomyocytes in the hypertrophied LV had enlarged mitochondria with less dense cristae. Although the mRNA expression of lipoprotein lipase in the LV of the cold-exposed chicks significantly increased, the mRNA expression of genes involved in fatty acid beta-oxidation did not change in response to cold exposure. In addition, the mRNA expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha, which enhances mitochondrial biogenesis and function under physiological cardiac hypertrophy, increased in LV of cold-exposed chicks. The study found that acute cold exposure to neonatal chicks induces LV hypertrophy. However, these results suggest that acute cold exposure to chicks might induce both adaptive and maladaptive responses of the LV.

    DOI: 10.1007/s00360-015-0957-x

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  • 鶏の骨格筋と脂肪の組織形成に対するβ<sub>2</sub>アドレナリン受容体シグナルの作用機序の解明

    井尻大地, 石丸善貴, 島元紗希, 石谷佳苗, 大塚彰

    栄養生理研究会報   59 ( 2 )   89 - 96   2015年10月

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    記述言語:日本語  

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  • Single injection of the β2-adrenergic receptor agonist, clenbuterol, into newly hatched chicks alters abdominal fat pad mass in growing birds. 査読

    Ishimaru Y, Ijiri D, Shimamoto S, Ishitani K, Nojima T, Ohtsuka A

    General and Comparative Endocrinology   211   9 - 13   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ygcen.2014.12.002

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  • The effects of intraperitoneal clenbuterol injection on protein degradation and myostatin expression differ between the sartorius and pectoral muscles of neonatal chicks 査読

    Daichi Ijiri, Kanae Ishitani, Saki Shimamoto, Yoshitaka Ishimaru, Akira Ohtsuka

    GENERAL AND COMPARATIVE ENDOCRINOLOGY   206   111 - 117   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    The purpose of this study was to investigate the effects of injection of the beta 2-adrenergic receptor agonist clenbuterol on the skeletal muscles of neonatal chicks (Gallus gallus domesticus). One-day-old chicks were randomly divided into four groups and given a single intraperitoneal injection of clenbuterol (0.01, 0.1, or 1 mg/kg) or phosphate-buffered saline. Twenty-four hours after the injection, the sartorius muscles (which consist of both slow- and fast-twitch fibers) of chicks that received 0.01 or 0.1 mg/kg clenbuterol were significantly heavier than those of controls, while there were no between-group differences in the weight of the pectoral muscles, which consist of only fast-twitch fibers. Muscle free N-t-methylhistidine, regarded as an index of myofibrillar proteolysis, was decreased in the sartorius muscle of the clenbuterol-injected chicks, while it was not affected in the pectoral muscles. In the sartorius muscle of the clenbuterol-injected chicks, myostatin and atrogin-1/MAFbx mRNA expressions were decreased, while in growth factor-I was unaffected. These observations suggested, in 1-day-old chicks, clenbuterol might increase mass of the sartorius muscle by decreasing myostatin gene expression and protein degradation. (C) 2014 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ygcen.2014.07.023

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MISC

  • ブロイラー初生雛への飼料給与の開始日齢が鶏肉に及ぼす影響 2)

    井尻大地, 宝蔵直樹, 島元紗希, 川口真奈, 古川愛理, 多田司, 友永省三, 中島一喜, 大塚彰

    鶏の研究   94 ( 2 )   16‐20   2019年2月

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    記述言語:日本語  

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  • ブロイラー初生雛への飼料給与の開始日齢が鶏肉に及ぼす影響 1)

    井尻大地, 宝蔵直樹, 島元紗希, 川口真奈, 古川愛理, 多田司, 友永省三, 中島一喜, 大塚彰

    鶏の研究   94 ( 1 )   22‐26   2019年1月

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    記述言語:日本語  

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講演・口頭発表等

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共同研究・競争的資金等の研究

  • 鶏肉品質を支配する要因の解明と品質の斉一性向上への取り組み

    研究課題/領域番号:21K14958  2021年4月 - 2024年3月

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    島元 紗希

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    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

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  • 筋原線維タンパク質由来3-メチルヒスチジンのミオシン分解機構への影響

    研究課題/領域番号:20K22609  2020年9月 - 2022年3月

    日本学術振興会  科学研究費助成事業 研究活動スタート支援  研究活動スタート支援

    島元 紗希

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    配分額:2860000円 ( 直接経費:2200000円 、 間接経費:660000円 )

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  • 肉用鶏における骨格筋量の個体差を支配する要因の解明と鶏肉生産への応用

    研究課題/領域番号:17J02494  2017年4月 - 2020年3月

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    島元 紗希

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    配分額:2800000円 ( 直接経費:2800000円 )

    長期的な飼料穀物の需給のひっ迫が懸念される状況下で、ブロイラーや地鶏などの肉用鶏の生産には、産肉性や飼料効率の向上が求められている。一方、生産現場では、肉用鶏の成長(体重や骨格筋の増加量)に大きな個体差が生じている。肉用鶏の体重や骨格筋量の個体差を最小化し、斉一性を高めることで産肉性と飼料効率の改善が可能となるが、個体差が生じる原因は不明である。
    アドレナリンは、副腎から分泌されるホルモンであり、骨格筋では主にβ2アドレナリン受容体(β2-AR)によって作用が伝達され、骨格筋間に現れるアドレナリンの作用の差異はβ2-ARの発現量に依存する。これらの情報から、同じ骨格筋(例えば浅胸筋)においても個体ごとにβ2-ARの発現量が異なれば、アドレナリンに対するβ2-ARシグナルの作用強度が異なる可能性が考えられる。本研究は、肉用鶏の体重・骨格筋量の個体差に対するβ2アドレナリン受容体の関連を明らかにし、鶏肉生産技術へ応用するための基盤情報を得ることを目的とする。
    本年度では、ニワトリβ2-ARの遺伝子配列からβ2-ARの特異的抗体を作製し、増体が遅い群と速い群のβ2-ARタンパク質の発現解析を調べた。加えて、環境要因によるβ2-AR発現量の個体差の原因を解明するため、本年度は、環境要因として飼料摂取量に注目し、群飼育条件下における成長が早い群と遅い群の飼料摂取量を比較し、続いて、飼料摂取量と骨格筋のβ2-AR発現量との関連性を調べた。

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