2025/10/12 更新

写真a

ショウドウ リュウスケ
正道 隆介
SHODO Ryusuke
所属
医歯学総合病院 耳鼻咽喉・頭頸部外科 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2017年9月   新潟大学 )

経歴

  • 新潟大学   医歯学総合病院 耳鼻咽喉・頭頸部外科   助教

    2020年4月 - 現在

 

論文

  • PD-L1 expression as a predictive biomarker in patients with recurrent or metastatic salivary gland carcinoma treated with pembrolizumab. 国際誌

    Takashi Matsuki, Daisuke Kawakita, Hideaki Takahashi, Takuro Okada, Akihiro Sakai, Yushi Ueki, Hiroshi Tsuge, Kenji Hanyu, Kaho Momiyama, Ryusuke Shodo, Mayu Yamauchi, Yukiko Asako, Hideaki Hirai, Toshitaka Nagao, Yuichiro Tada

    Scientific reports   14 ( 1 )   19794 - 19794   2024年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Although immune checkpoint inhibitors (ICIs) are effective in some patients with salivary gland carcinoma (SGC), biomarkers which predict the efficacy and prognosis of SGC patients treated with pembrolizumab have not been identified. We conducted a multi-institutional retrospective cohort study to evaluate the efficacy and safety of pembrolizumab monotherapy in patients with recurrent and/or metastatic SGC and to determine optimal cut-off values of the combined positive score (CPS) and tumor proportion score (TPS) as numerical expression levels of programmed death-ligand 1 (PD-L1), which predict the efficacy of pembrolizumab. Furthermore, we investigated the association of patient characteristics and hematological markers with clinical outcomes, including overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). From 2016 to 2021, 27 patients were included in the analysis. ORR of SGC was 25.9%. Optimal cut-off values of CPS and TPS were 15 and 25%, respectively. ORRs of CPS-high and TPS-high were 55.6 and 75.0%, respectively, and significantly higher than those of CPS-low and TPS-low. Furthermore, patients with a low platelet-lymphocyte ratio (PLR) had a significantly longer PFS. No grade 4 or greater adverse events were observed. This study demonstrated the efficacy and safety of pembrolizumab monotherapy and identified optimal cut-off values of CPS and TPS.

    DOI: 10.1038/s41598-024-70779-8

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  • Aortic rupture following acute aortitis in a patient with head and neck carcinoma treated with nivolumab: a rare but severe immune-related adverse event. 国際誌

    Yuki Ohno, Yushi Ueki, Shusuke Oshima, Jo Omata, Yusuke Yokoyama, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Arata Horii

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   281 ( 4 )   2037 - 2040   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Immune-related adverse events (irAEs) due to immune checkpoint inhibitors may lead to discontinuation and treatment-related death. Acute aortitis is a rare but severe irAE. CASE PRESENTATION: A 67-year-old man with recurrent lower gingival carcinoma received nivolumab therapy. Twenty-three months later, he experienced chest compression, which resulted in syncope. Following a whole-body computed tomography (CT) scanning, which revealed diffuse thickening of the aorta, and systemic assessments of the causes of aortitis, he was diagnosed with acute aortitis due to irAE. Nivolumab discontinuation and oral steroids improved CT findings. However, 11 months after nivolumab discontinuation, he developed an aortic aneurysmal rupture. Endovascular aortic repair rescued him. A durable anti-cancer response was still observed 4 months after the aortic rupture. CONCLUSION: Although severe irAE, such as acute aortitis, occurred, the patient may still achieve a durable response. A broad examination and prompt treatment of irAE can help improve the patient's survival.

    DOI: 10.1007/s00405-024-08495-2

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  • Multicenter prospective phase II trial of concurrent chemoradiotherapy with weekly low-dose carboplatin for cisplatin-ineligible patients with advanced head and neck squamous cell carcinoma.

    Yushi Ueki, Shusuke Ohshima, Yusuke Yokoyama, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Kohei Ohtaki, Kohei Saijo, Ryoko Tanaka, Takafumi Togashi, Yuichiro Sato, Satoshi Takano, Jo Omata, Nao Takahashi, Ryuichi Okabe, Arata Horii

    International journal of clinical oncology   29 ( 1 )   20 - 26   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The optimal chemotherapy regimen in concurrent chemoradiotherapy (CCRT) for cisplatin-ineligible head and neck squamous cell carcinoma (HNSCC) has not been established. We aimed to evaluate the feasibility, efficacy, and safety of CCRT with weekly low-dose carboplatin for the treatment of advanced HNSCC in patients who are cisplatin-ineligible. METHODS: This prospective phase II study enrolled adult patients (age ≥ 20 years) with HNSCC receiving whole-neck irradiation including bilateral levels II-IV and who were aged (≥ 75-year-old patients with 40 mL/min estimated glomerular filtration rate [eGFR] or better) or had renal dysfunction (< 75-year-old patients with 30-60 mL/min eGFR). Carboplatin was administered weekly (area under the plasma concentration-time curve = 2.0) for up to seven cycles during concurrent radiotherapy (70 Gy/35 Fr). The primary endpoint was the completion rate of CCRT. Secondary endpoints included overall response rate and incidence of adverse events. RESULTS: Among the 30 patients enrolled, 28 were men. The median age was 73.5 years. Seventeen patients were < 75 years whereas 13 were ≥ 75 years old. The completion rate of CCRT was 90%. The overall response rate was 90%. Grade 3 adverse events that occurred in 10% or more patients were oral/pharyngeal mucositis (47%), leukocytopenia (20%), and neutropenia (10%). Grade 4 adverse events occurred in one patient (elevation of alanine aminotransferase level). No treatment-related deaths occurred. CONCLUSION: CCRT with weekly low-dose carboplatin is a promising treatment option, with favorable feasibility, efficacy, and acceptable toxicity, for patients who are cisplatin-ineligible with advanced HNSCC. CLINICAL TRIAL REGISTRATION NUMBER: jRCTs031190028.

    DOI: 10.1007/s10147-023-02423-w

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  • Sarcopenia Index Predicts Short-Term Prognosis of Head and Neck Squamous Cell Carcinoma. 国際誌

    Ryusuke Shodo, Keisuke Yamazaki, Yushi Ueki, Takeshi Takahashi, Yusuke Yokoyama, Arata Horii

    Nutrition and cancer   76 ( 2 )   149 - 159   2024年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The sarcopenia index (SI), calculated as [(serum creatinine/serum cystatin C) × 100], maybe a simpler alternative for measuring muscle mass than computed tomography (CT) and bioelectrical impedance analysis (BIA). We enrolled 112 patients with head and neck cancers (HNC). The correlation of the SI with muscle surface area measured by CT (CTMSA, n = 82) and muscle mass by BIA (BIA-MM, n = 41) was tested. Cutoff values were set for SI, CTMSA, and BIA-MM. Overall survival (OS) was compared between the high- and low-SI/CTMSA/BIA-MM groups. The SI was correlated with CTMSA (r = 0.43) and BIA-MM (r = 0.52). The optimal cutoff values of SI, CTMSA, and BIA-MM were 76.1 (area under the curve [AUC] = 0.67), 129.2 (AUC = 0.59), and 46.1 (AUC = 0.62), respectively. OS was significantly lower in the low-SI group (78% at 1 year and 69% at 2 years) than in the high-SI group (94% at 1 year and 86% at 2 years; p = 0.006). There was no significant difference in OS between the low-and high-CTMSA and -BIA-MM groups. The SI, which only requires a blood sample, is a useful marker of muscle mass that correlates with short-term prognosis in patients with HNC.

    DOI: 10.1080/01635581.2023.2290299

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  • Safety and efficacy of neoadjuvant chemotherapy with paclitaxel, carboplatin, and cetuximab for locally advanced head and neck squamous cell carcinoma

    Ryoko Tanaka, Yushi Ueki, Shusuke Ohshima, Jo Omata, Yusuke Yokoyama, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Kohei Ohtaki, Takafumi Togashi, Arata Horii

    International Journal of Clinical Oncology   2024年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10147-024-02545-9

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  • Genomic analysis of radiation-induced osteosarcoma in the maxilla

    Yusuke Yokoyama, Yushi Ueki, Shusuke Ohshima, Jo Omata, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Arata Horii

    Oral Oncology Reports   8   100107 - 100107   2023年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.oor.2023.100107

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  • Role of eosinophilia in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab: Prediction of immune-related adverse events and favorable outcome. 国際誌

    Yushi Ueki, Shusuke Ohshima, Jo Omata, Yusuke Yokoyama, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Arata Horii

    Cancer medicine   12 ( 22 )   20810 - 20820   2023年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Immune-related adverse events (irAEs) are prognostic factors for patients on nivolumab. However, predictors of irAEs have not yet been identified. We aimed to investigate the predictors of irAEs occurrence and nivolumab discontinuation due to irAEs. METHODS: Sixty-two patients with recurrent/metastatic head and neck squamous cell carcinoma received nivolumab therapy between June 2017 and December 2020. Treatment outcome was compared between the groups with or without irAEs. The irAE (+) group was further divided by nivolumab discontinuation. Progression-free survival (PFS) and overall survival (OS) were compared between the groups. Predictors of irAE occurrence were analyzed. RESULTS: Twenty-one patients (33.9%) developed irAEs, and six (28.6%) discontinued nivolumab due to severe irAEs. The irAE (+) group had significantly longer PFS and OS than the irAE (-) group (median PFS, 12.7 vs. 1.9 months; median OS, 33.1 vs. 12.8 months). The treatment outcomes in the discontinuation group were comparable to those in the non-discontinuation group. The maximum absolute eosinophil count (AEC) during nivolumab therapy was significantly higher in the irAE (+) group than in the irAE (-) group (548.8 vs. 182) and higher in the discontinuation group than in the non-discontinuation group (729.3 vs. 368.6). The receiver operating characteristic curve showed that the maximum AEC had a moderate-to-high accuracy for predicting irAE occurrence (area under the curve [AUC], 0.757) and nivolumab discontinuation (AUC, 0.893). DISCUSSION: Monitoring AEC during nivolumab therapy may be useful in predicting irAE occurrence, nivolumab discontinuation, and disease prognosis.

    DOI: 10.1002/cam4.6648

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  • Treatment Outcome in Head and Neck Cancer With Distant Metastasis at Initial Diagnosis. 国際誌

    Jo Omata, Yushi Ueki, Yuto Takahashi, Ryoko Tanaka, Yusuke Yokoyama, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Takafumi Togashi, Hiroshi Matsuyama, Nao Takahashi, Ryuichi Okabe, Arata Horii

    The Laryngoscope   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) treatment has changed dramatically with the introduction of immune checkpoint inhibitors (ICIs). However, there are few reports of treatment outcomes on HNSCC with distant metastasis (M1) at initial diagnosis, and its treatment strategy has not been standardized. We aimed to analyze the treatment outcome and prognostic factors of patients with HNSCC with initial M1 disease. METHODS: In this multi-institutional retrospective study, 98 patients with HNSCC were initially diagnosed with M1 disease between 2007 and 2021. The patients were divided into the non-palliative (received any systemic chemotherapy, n = 60) and palliative (did not receive systemic chemotherapy, n = 38) groups. Overall survival (OS) was compared between the groups. In the non-palliative group, predictors of OS were explored based on patient characteristics and treatment details. RESULTS: The median OS in the non-palliative group was 15 months (95% confidence interval [CI], 10-20), which was significantly longer than that in the palliative group (3 months, 95% CI, 2-5) (p < 0.001). Multivariate analysis revealed that administration of locoregional radiation therapy (RT) (hazard ratio [HR] 0.407 [95% CI 0.197-0.844]; p = 0.016), ICIs (HR 0.216 [95% CI 0.088-0.532]; p < 0.001) and RT/surgery for distant metastasis (HR 0.373 [95% CI 0.150-0.932]; p = 0.034) were the independent prognostic factors of OS. CONCLUSION: An intensive treatment strategy combining systemic therapy using ICIs with RT/surgery for locoregional or distant metastasis may yield a survival benefit for patients with HNSCC with M1 disease. LEVEL OF EVIDENCE: 4 Laryngoscope, 2023.

    DOI: 10.1002/lary.31047

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  • The effect of prophylactic use of Episil oral liquid on oral mucositis in head and neck cancer patients undergoing concurrent chemoradiotherapy 査読

    Katsura K, Yoshida K, Yamazaki K, Soga M, Tanaka Y, Tanaka K, Shodo R, Ueki Y, Takahashi T, Kobayashi T, Ishiyama M, Kanemaru H, Hayashi T

    Supportive Care in Cancer   31 ( Suppl 1 )   82 - 83   2023年6月

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    DOI: 10.1007/s00520-023-07786-4

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  • Near-Infrared Autofluorescence Identification of Ectopic Parathyroid Lesions. 国際誌

    Kanako Abe, Takeshi Takahashi, Yusuke Yokoyama, Ryusuke Shodo, Yushi Ueki, Keisuke Yamazaki, Arata Horii

    The Laryngoscope   2023年5月

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    記述言語:英語  

    Ectopic parathyroid lesions can be difficult to detect. In the present study, we used near-infrared autofluorescence imaging (NIFI) in three cases of ectopic parathyroid lesions. Our results suggest that NIFI may be a confirmation tool for parathyroid pathology and an intraoperative navigation tool in vivo and ex vivo. Laryngoscope, 2023.

    DOI: 10.1002/lary.30728

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  • Nivolumab投与後免疫関連有害事象としての大動脈炎による胸部大動脈瘤破裂を生じた1例

    大野 佑樹, 植木 雄志, 大島 秀介, 尾股 丈, 横山 侑輔, 高橋 剛史, 正道 隆介, 山崎 恵介, 堀井 新

    頭頸部癌   49 ( 2 )   138 - 138   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 内側腓腹動脈穿通枝皮弁(MSAP皮弁)を用いて喉頭・下咽頭再建を行った4症例の検討

    山崎 恵介, 曽束 洋平, 植木 雄志, 正道 隆介, 高橋 剛史, 横山 侑輔, 松田 健, 堀井 新

    頭頸部癌   49 ( 2 )   143 - 143   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 再発転移頭頸部癌に対するペムブロリズマブの治療成績 併用療法と単剤療法の比較

    植木 雄志, 大島 秀介, 尾股 丈, 横山 侑輔, 高橋 剛史, 正道 隆介, 山崎 恵介, 堀井 新

    頭頸部癌   49 ( 2 )   185 - 185   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 頭頸部扁平上皮癌M1症例における局所治療の役割

    尾股 丈, 横山 侑輔, 高橋 剛史, 正道 隆介, 植木 雄志, 山崎 恵介, 堀井 新, 富樫 孝文, 田中 亮子, 松山 洋, 高橋 優人, 岡部 隆一, 高橋 奈央

    頭頸部癌   49 ( 2 )   154 - 154   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 再発転移頭頸部癌に対するペムブロリズマブの治療成績 併用療法と単剤療法の比較

    植木 雄志, 大島 秀介, 尾股 丈, 横山 侑輔, 高橋 剛史, 正道 隆介, 山崎 恵介, 堀井 新

    頭頸部癌   49 ( 2 )   185 - 185   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • Nivolumab投与後免疫関連有害事象としての大動脈炎による胸部大動脈瘤破裂を生じた1例

    大野 佑樹, 植木 雄志, 大島 秀介, 尾股 丈, 横山 侑輔, 高橋 剛史, 正道 隆介, 山崎 恵介, 堀井 新

    頭頸部癌   49 ( 2 )   138 - 138   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 内側腓腹動脈穿通枝皮弁(MSAP皮弁)を用いて喉頭・下咽頭再建を行った4症例の検討

    山崎 恵介, 曽束 洋平, 植木 雄志, 正道 隆介, 高橋 剛史, 横山 侑輔, 松田 健, 堀井 新

    頭頸部癌   49 ( 2 )   143 - 143   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 甲状腺全摘を伴う下咽頭・喉頭癌手術時の副甲状腺自家移植における近赤外線装置の有用性について

    高橋 剛史, 横山 侑輔, 正道 隆介, 植木 雄志, 山崎 恵介, 富樫 孝文, 松山 洋, 堀井 新

    日本耳鼻咽喉科頭頸部外科学会会報   126 ( 4 )   588 - 588   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科頭頸部外科学会  

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  • シスプラチン不耐頭頸部扁平上皮癌に対するカルボプラチン毎週投与併用化学放射線治療 第II相試験結果報告

    植木 雄志, 大島 秀介, 横山 侑輔, 高橋 剛史, 正道 隆介, 山崎 恵介, 高野 哲, 高橋 奈央, 岡部 隆一, 大滝 耕平, 西條 幸平, 田中 亮子, 太田 久幸, 富樫 孝文, 佐藤 雄一郎, 堀井 新

    日本耳鼻咽喉科頭頸部外科学会会報   126 ( 4 )   630 - 630   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科頭頸部外科学会  

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  • 頭頸部癌放射線治療症例における口腔咽頭カンジダ症

    正道 隆介, 横山 侑輔, 高橋 剛史, 植木 雄志, 山崎 恵介, 堀井 新

    日本耳鼻咽喉科頭頸部外科学会会報   126 ( 4 )   666 - 666   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科頭頸部外科学会  

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  • 頭頸部悪性腫瘍新患登録33年の変遷 新潟県における検討

    富樫 孝文, 太田 久幸, 田中 亮子, 西條 幸平, 尾股 丈, 横山 侑輔, 高橋 剛史, 正道 隆介, 植木 雄志, 岡部 隆一, 山崎 恵介, 松山 洋, 本田 耕平, 佐藤 雄一郎, 堀井 新, 新潟県頭頸部悪性腫瘍登録委員会

    日本耳鼻咽喉科頭頸部外科学会会報   126 ( 1 )   38 - 45   2023年1月

  • Actual prevalence of hypoparathyroidism after total thyroidectomy: a health insurance claims-database study. 国際誌

    Takeshi Takahashi, Keisuke Yamazaki, Ryusuke Shodo, Yushi Ueki, Arata Horii

    Endocrine   78 ( 1 )   151 - 158   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Persistent hypoparathyroidism (hypoPT) is a major complication of total thyroidectomy. Nonetheless, previous reports may have underestimated the prevalence of hypoPT due to patient selection bias. We aimed to estimate the actual prevalence of persistent hypoPT after total thyroidectomy and to find predictive factors for postoperative hypoPT. METHODS: This study retrospectively reviewed data from a health insurance claims-based database provided by the Japan Medical Data Center Co., Ltd. From 2009 to 2019, 2388 patients who underwent total thyroidectomy were identified using the medical procedure codes. Persistent hypoPT was defined as the prescription of active vitamin D supplements for >1 year postoperatively and the assignment of hypoPT codes. The prevalence of persistent hypoPT was estimated at two different levels: minimum and maximum estimations with or without postoperative osteoporosis and/or renal failure codes. Correlates for persistent hypoPT were investigated among several demographic and clinical variables. RESULTS: Of the 2388 patients, 1752 (73.4%) were women with a mean age of 45 years. The types of diseases were: benign thyroid disease (n = 235), malignant thyroid tumors (n = 1570), Graves ' disease (n = 558), and malignancy combined with Graves' disease (n = 25). The minimum and the maximum estimation of the prevalence of persistent hypoPT were 15.0 and 20.3%, respectively. Multivariate logistic regression analysis showed that the malignant tumor (odds ratio, 1.8) independently correlated with persistent hypoPT. CONCLUSIONS: The prevalence of persistent hypoPT after total thyroidectomy estimated by the claims-based database was higher than previously recognized. Comprehensive attempts to preserve parathyroid function, especially in malignant diseases, are essential.

    DOI: 10.1007/s12020-022-03153-1

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  • Head and neck cancer fungating wounds: a novel odour transferrer. 国際誌

    Hisayuki Ota, Yushi Ueki, Keisuke Yamazaki, Ryusuke Shodo, Takeshi Takahashi, Yusuke Yokoyama, Arata Horii

    BMJ supportive & palliative care   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The management for malodour of malignant fungating wounds (MFWs) in head and neck cancer (HNC) is unestablished. We evaluated the effects of a novel odour transferrer on malodour generated by MFWs in patients with HNC. METHODS: A spray-type odour transferrer approved by the Japanese government for safe use in humans produces a good scent by binding to bad odour. The odour of MFWs in 13 patients with HNC was scored by 37 medical staff and the patients' families using an odour scale ranging from 0 to 4 before and 1 week after application of the odour transferrer. RESULTS: The odour score marked by all investigators (n=37), nurses (n=21) and doctors (n=11) decreased significantly (p<0.01). The odour score decreased by more than 2 points for 73% of all investigators after odour transferrer application. CONCLUSION: This novel odour transferrer functions as an effective deodorant for MFWs in patients with HNC. It can be used by non-medical staff and may benefit patients with bad odours arising from MFWs as well as their families and medical staff.

    DOI: 10.1136/spcare-2022-003824

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  • サルコペニアインデックスは頭頸部癌の短期予後を予測する

    正道 隆介, 大島 秀介, 横山 侑輔, 高橋 剛史, 植木 雄志, 山崎 恵介, 堀井 新

    頭頸部癌   48 ( 2 )   188 - 188   2022年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 鼻副鼻腔扁平上皮癌におけるヒトパピローマウイルス感染の意義

    高野 哲, 植木 雄志, 大島 秀介, 横山 侑輔, 高橋 剛史, 正道 隆介, 山崎 恵介, 松山 拓, 橋立 英樹, 堀井 新

    頭頸部癌   48 ( 2 )   200 - 200   2022年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • ニボルマブ治療における免疫関連有害事象 発症および重症度予測因子としての血中好酸球の有用性

    植木 雄志, 大島 秀介, 横山 侑輔, 高橋 剛史, 正道 隆介, 山崎 恵介, 堀井 新

    頭頸部癌   48 ( 2 )   144 - 144   2022年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • ソノペットIQを用いた上顎全摘術

    山崎 恵介, 高橋 剛史, 大島 秀介, 正道 隆介, 植木 雄志, 堀井 新

    頭頸部癌   48 ( 2 )   201 - 201   2022年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • Head and neck small-cell carcinoma: A multicenter study of 39 cases from 10 institutions. 国際誌

    Hiroshi Matsuyama, Yushi Ueki, Isaku Okamoto, Toshitaka Nagao, Kohei Honda, Keisuke Yamazaki, Ryuichi Okabe, Takafumi Togashi, Ryusuke Shodo, Hisayuki Ota, Takeshi Takahashi, Jo Omata, Yusuke Yokoyama, Kohei Saijo, Ryoko Tanaka, Kiyoaki Tsukahara, Tadashi Kitahara, Hirokazu Uemura, Seiichi Yoshimoto, Fumihiko Matsumoto, Kenji Okami, Akihiro Sakai, Kenichi Takano, Atsushi Kondo, Hidenori Inohara, Hirotaka Eguchi, Nobuhiko Oridate, Teruhiko Tanabe, Munenaga Nakamizo, Kazuhiko Yokoshima, Koki Miura, Yosuke Kitani, Arata Horii

    Frontiers in surgery   9   1049116 - 1049116   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Basal information of head and neck small-cell carcinoma (HNSmCC) including epidemiology, primary site, treatment, and prognosis remains sparse due to its rarity. We report here a multicenter retrospective study on the diagnosis, treatment, and outcomes of patients with HNSmCC. MATERIALS AND METHODS: This study involved 47 patients with HNSmCC from 10 participating institutions. Eight patients were excluded for whom no pathological specimens were available (n = 2) and for discrepant central pathological judgements (n = 6). The remaining 39 patients were processed for data analysis. RESULTS: As pretreatment examinations, computed tomography (CT) was performed for the brain (n = 8), neck (n = 39), and chest (n = 32), magnetic resonance imaging (MRI) for the brain (n = 4) and neck (n = 23), positron emission tomography-CT (PET-CT) in 23 patients, bone scintigraphy in 4, neck ultrasonography in 9, and tumor markers in 25. Primary sites were oral cavity (n = 1), nasal cavity/paranasal sinuses (n = 16), nasopharynx (n = 2), oropharynx (n = 4), hypopharynx (n = 2), larynx (n = 6), salivary gland (n = 3), thyroid (n = 2), and others (n = 3). Stages were II/III/IV-A/IV-B/IV-C/Not determined = 3/5/16/6/5/4; stage IV comprised 69%. No patient had brain metastases. First-line treatments were divided into 3 groups: the chemoradiotherapy (CRT) group (n = 27), non-CRT group (n = 8), and best supportive care group (n = 4). The CRT group included concurrent CRT (CCRT) (n = 17), chemotherapy (Chemo) followed by radiotherapy (RT) (n = 5), and surgery (Surg) followed by CCRT (n = 5). The non-CRT group included Surg followed by RT (n = 2), Surg followed by Chemo (n = 1), RT alone (n = 2), and Chemo alone (n = 3). The 1-year/2-year overall survival (OS) of all 39 patients was 65.3/53.3%. The 1-year OS of the CRT group (77.6%) was significantly better compared with the non-CRT group (31.3%). There were no significant differences in adverse events between the CCRT group (n = 22) and the Chemo without concurrent RT group (n = 9). CONCLUSION: Neck and chest CT, neck MRI, and PET-CT would be necessary and sufficient examinations in the diagnostic set up for HNSmCC. CCRT may be recommended as the first-line treatment. The 1-year/2-year OS was 65.3%/53.3%. This study would provide basal data for a proposing the diagnostic and treatment algorithms for HNSmCC.

    DOI: 10.3389/fsurg.2022.1049116

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  • Treatment outcomes of mucosal melanoma of head and neck: Efficacy of immune checkpoint inhibitors for advanced disease. 国際誌

    Shusuke Ohshima, Yushi Ueki, Yusuke Yokoyama, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Ryuichi Okabe, Hiroshi Matsuyama, Takafumi Togashi, Sumiko Takatsuka, Tatsuya Takenouchi, Arata Horii

    Frontiers in surgery   9   1032626 - 1032626   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Head and neck mucosal melanoma (HNMM) is a rare and aggressive subtype of melanoma. HNMM often develops as a recurrent or metastatic disease, and its prognosis is worse than that of cutaneous melanoma. Recent large-scale clinical studies have reported favorable outcomes with immune checkpoint inhibitors (ICIs) for melanoma. However, these clinical trials included only a small number of HNMM cases. This study aimed to estimate treatment outcomes and prognostic predictors of ICIs for advanced HNMM. METHODS: Cases of advanced HNMM, defined as unresectable or metastatic HNMM at the initial diagnosis (five patients) or development of recurrent/metastatic HNMM after initial treatment (27 patients), were included in this study. Survival analysis and a search for prognostic factors were performed for these 32 patients. Furthermore, the detailed clinical course of patients who received ICI treatment was investigated. RESULTS: The median overall survival (OS) of 32 patients with advanced HNMM was 25.3 months. The estimated 1-, 3-, and 5-year OS rates were 68.4%, 42.8%, and 34.3%, respectively. Fourteen patients (43.7%) received ICIs, whereas 18 (56.3%) did not. Univariate analysis showed that ICI treatment was the only factor associated with a better 1-year OS. Patients who received ICI treatment had significantly longer OS (median OS: not reached, 1-year OS: 85.7%) than those who did not (median OS: 11.3 months, 1-year OS: 54.5%). The overall response and disease control rates of patients who received ICI treatment were 50% and 64.3%, respectively. Patients who achieved complete response (CR) or partial response (PR) to ICI treatment survived significantly longer (1-year OS: 100%) than those who did not (1-year OS: 71.4%). Among the five patients who discontinued ICI treatment due to severe immune-related adverse events (irAEs), four did not receive salvage treatments but showed durable treatment effects and survived for 9.8-54.2 months at the end of the follow-up period. CONCLUSIONS: ICI treatment achieved a favorable OS for advanced HNMM. CR/PR to ICI treatment and discontinuation owing to severe irAEs were favorable predictors of OS.

    DOI: 10.3389/fsurg.2022.1032626

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  • Chemoradiotherapy with 3-weekly CDDP 80 mg/m2 for head and neck squamous cell carcinoma: 5-year survival data from a phase 2 study. 国際誌

    Kohei Otaki, Takeshi Takahashi, Ryoko Tanaka, Kohei Saijo, Jo Omata, Yusuke Yokoyama, Ryusuke Shodo, Yushi Ueki, Keisuke Yamazaki, Hisayuki Ota, Takafumi Togashi, Nao Takahashi, Ryuichi Okabe, Hiroshi Matsuyama, Arata Horii

    Frontiers in surgery   9   1035349 - 1035349   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The global standard for chemoradiation therapy (CCRT) for head and neck squamous cell carcinoma is cisplatin 100 mg/m2 administered once every three weeks, although cisplatin 80 mg/m2 is also widely used as an alternative treatment to reduce adverse events in Japan. We aimed to assess the long-term survival outcomes and late adverse events associated with CCRT with a 3-weekly cisplatin dose of 80 mg/m2. METHODS: A phase 2 study on CCRT with a 3-weekly cisplatin dose of 80 mg/m2 was performed in 47 patients between April 2015 and December 2016 at four centers in Japan. Survival outcomes and late adverse events at 5 years after this phase 2 trial were investigated. RESULTS: The median follow-up period was 61 months. The 5-year progression-free survival/overall survival of all 47 patients was 66.0%/76.6%, while that of patients with stage III, IV disease (UICC) was 65.6%/71.9%. Seventeen patients (36%) experienced dysphagia as a late adverse event. Univariate and multivariate analyses revealed a significant association between acute mucositis/low body mass index (BMI) during CCRT and late dysphagia. CONCLUSION: The survival outcomes of CCRT with a 3-weekly cisplatin dose of 80 mg/m2 may be comparable to the previously reported dose of 100 mg/m2. Acute mucositis and low BMI at CCRT were risk factors for late dysphagia, indicating the importance of managing these conditions during CCRT to prevent late adverse events. Caution and care for acute mucositis and swallowing training in patients with low BMI may be important for preventing late-stage dysphagia.

    DOI: 10.3389/fsurg.2022.1035349

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  • Comparison of Autofluorescence With Near-Infrared Fluorescence Imaging Between Primary and Secondary Hyperparathyroidism. 国際誌

    Mika Takeuchi, Takeshi Takahashi, Ryusuke Shodo, Hisayuki Ota, Yushi Ueki, Keisuke Yamazaki, Arata Horii

    The Laryngoscope   131 ( 6 )   E2097-E2104   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: To examine the role of autofluorescence (AF) monitoring with near-infrared fluorescence imaging (NIFI) in identifying parathyroid lesions in primary or secondary hyperparathyroidism (P-HPT or S-HPT) surgeries. STUDY DESIGN: Prospective study. METHODS: Twelve lesions each were resected from 12 and 3 patients with P-HPT and S-HPT, respectively. The mean and maximum AF intensities of the lesions normalized to that of the thyroid tissue for in situ and ex vivo preparations were compared between P-HPT and S-HPT. Subjective visual classifications of AF intensity were compared with postoperative quantitative assessments. The unevenness of AF distribution inside the lesions was assessed by determining the ratio of maximum to mean AF intensity and comparing them with the corresponding ratio for normal parathyroid glands (PGs). RESULTS: In all quantitative comparisons (in situ/ex vivo, mean, and maximum AF), AF intensities of P-HPT were stronger than those of S-PHT. The AF-positive rate in in situ subjective visual classification was higher for P-HPT (100% vs. 33%). Subjective visual classifications showed a positive correlation with AF intensities. The ratio of maximum to mean AF was higher in P-HPT and S-HPT than in normal PGs. CONCLUSIONS: For P-HPT, AF intensity in both in situ and ex vivo preparations was sufficiently high and correlated with the subjective visual classification, suggesting that NIFI may be useful for confirming P-HPT lesions. In contrast, NIFI may have only a minor role in S-HPT surgeries owing to the weak-AF of S-HPT lesions. HPT lesions show an uneven AF intensity distribution compared with normal PGs. LEVEL OF EVIDENCE: 3 Laryngoscope, 131:E2097-E2104, 2021.

    DOI: 10.1002/lary.29310

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  • 高齢頭頸部癌患者における高用量シスプラチン併用化学放射線療法の安全性および治療成績についての検討

    尾股 丈, 植木 雄志, 高橋 剛史, 正道 隆介, 富樫 孝文, 山崎 恵介, 佐藤 雄一郎, 堀井 新

    頭頸部癌   47 ( 2 )   213 - 213   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • Near-Infrared Fluorescence Imaging in the Identification of Parathyroid Glands in Thyroidectomy. 国際誌

    Takeshi Takahashi, Keisuke Yamazaki, Hisayuki Ota, Ryusuke Shodo, Yushi Ueki, Arata Horii

    The Laryngoscope   131 ( 5 )   1188 - 1193   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES/HYPOTHESIS: To assess the ability of near-infrared fluorescence imaging (NIFI) to identify parathyroid glands (PGs) among histologically proven PG/non-PG specimens compared with a surgeon's visual acumen, and to determine NIFI sensitivity in detecting incidentally resected PGs from thyroidectomy specimens, compared to the surgeon's visual inspection. STUDY DESIGN: Prospective study. METHODS: With mean age of 61 years, 36 patients with various thyroid diseases were enrolled. Possible PGs (n = 28) and lymph nodes (n = 32) were identified by the experienced surgeon's visual inspection. Using NIFI, 15 PGs were further identified from thyroidectomy specimens. For these 75 specimens, the surgeon's judgments (PG vs. non-PG) were recorded. Histological evaluation was performed after examining the NIFI auto-fluorescence of each specimen. RESULTS: There were no significant differences in sensitivity, specificity, positive predictive value, and negative predictive value between the surgeon's visual inspection and NIFI in identifying PGs, with values of 100%/97.1%, 85.0%/87.5%, 85.4%/87.2%, and 100%/97.2%, respectively. The sensitivity of NIFI (82.9%) for detection of PGs from thyroidectomy specimens was significantly higher than that of the surgeon's visual inspection (61.0%). False negative specimens contained bleeding/congestion and/or encapsulation by thick tissues, whereas false positive specimens contained electrocoagulated tissues. CONCLUSIONS: NIFI showed results comparable to the experienced surgeon's visual inspection in identifying PGs. This could benefit novice surgeons. NIFI may be useful for experienced surgeons to locate incidentally resected PGs within thyroidectomy specimens for auto-transplantation. Prevention of intra-gland bleeding and congestion, careful removal of thick capsules, and bloodless surgeries without electrocoagulation are important for reducing false positive and false negative results. Laryngoscope, 131:1188-1193, 2021.

    DOI: 10.1002/lary.29163

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  • In Response to Regarding Near-Infrared Fluorescence Imaging in the Identification of Parathyroid Glands in Thyroidectomy. 国際誌

    Takeshi Takahashi, Keisuke Yamazaki, Hisayuki Ota, Ryusuke Shodo, Yushi Ueki, Arata Horii

    The Laryngoscope   131 ( 5 )   E1749   2021年5月

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    記述言語:英語  

    DOI: 10.1002/lary.29425

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  • 頭頸部小細胞癌の多施設調査

    松山 洋, 山崎 恵介, 植木 雄志, 正道 隆介, 高橋 剛史, 堀井 新, 塚原 清彰, 岡本 伊作, 長尾 俊孝, 北原 糺, 上村 裕和, 吉本 世一, 松本 文彦, 大上 研二, 酒井 昭博, 高野 賢一, 近藤 敦, 猪原 秀典, 江口 博孝, 折舘 伸彦, 田辺 輝彦, 中溝 宗永, 横島 一彦, 三浦 弘規, 木谷 洋輔

    頭頸部癌   47 ( 2 )   190 - 190   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 頭頸部粘膜原発悪性黒色腫33例の治療成績 特に免疫チェックポイント阻害剤の効果に関して

    大島 秀介, 植木 雄志, 高橋 剛史, 正道 隆介, 山崎 恵介, 岡部 隆一, 松山 洋, 富樫 孝文, 佐藤 雄一郎, 堀井 新

    頭頸部癌   47 ( 2 )   206 - 206   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 末梢挿入型中心静脈カテーテル先端位置・合併症の左右差比較

    高橋 優人, 正道 隆介, 高橋 剛史, 植木 雄志, 山崎 恵介, 堀井 新

    日本耳鼻咽喉科学会会報   124 ( 2 )   122 - 127   2021年2月

  • 近赤外線装置を用いた副甲状腺の自家蛍光観察pde-neoとFLUOBEAM800の比較

    高橋 剛史, 山崎 恵介, 竹内 美香, 正道 隆介, 太田 久幸, 植木 雄志, 堀井 新

    頭頸部外科   30 ( 3 )   277 - 283   2021年2月

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    記述言語:日本語   出版者・発行元:(NPO)日本頭頸部外科学会  

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  • Treatment Outcome of External Auditory Canal Carcinoma: The Utility of Lateral Temporal Bone Resection. 国際誌

    Kohei Saijo, Yushi Ueki, Ryoko Tanaka, Yusuke Yokoyama, Jo Omata, Takeshi Takahashi, Hisayuki Ota, Ryusuke Shodo, Keisuke Yamazaki, Takafumi Togashi, Ryuichi Okabe, Hiroshi Matsuyama, Kohei Honda, Yuichiro Sato, Yuka Morita, Kuniyuki Takahashi, Arata Horii

    Frontiers in surgery   8   708245 - 708245   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We examined the role of lateral temporal bone resection (LTBR) in the treatment of external ear canal (EAC) carcinoma between 2007 and 2018. The estimated 3-year disease-free survival (DFS) and disease-specific survival (DSS) according to the tumor stage and treatments were investigated in 36 patients with EAC squamous cell carcinoma. T stage classification according to the University of Pittsburgh staging system was as follows: 14 patients in T1, four patients in T2, nine patients in T3, and nine patients in T4. The 3-year DFS rate was 77.4% for T1 tumors, 100% for T2, 44.4% for T3 tumors, and 11.1% for T4 tumors (p < 001). The 3-year DSS rate was 100% for T1/T2 tumors, 87.5% for T3 tumors, and 11.1% for T4 tumors (p < 0.01). T1/T2 patients received mostly LTBR. Among nine T3 tumors, five patients (56%) received LTBR combined with preoperative chemotherapy and/or postoperative radiation (RT). Four of them had negative surgical margin and survived with no evidence of disease. The DFS of T3 patients who underwent concurrent chemoradiotherapy and LTBR was 0 and 80%, respectively (p = 0.048). For T1/T2 tumors, surgery achieved an excellent outcome. For T3 tumors, LTBR achieved negative surgical margin and showed good survival when combined with preoperative chemotherapy and/or postoperative RT. In contrast, the prognosis of T3 patients who could not undergo surgery was as poor as that of T4 patients. Therefore, in addition to subtotal temporal bone resection, LTBR-based treatment strategy may be a treatment option for limited cases of T3 patients.

    DOI: 10.3389/fsurg.2021.708245

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  • Treatment Outcomes and the Safety of Chemoradiotherapy With High-Dose CDDP for Elderly Patients With Head and Neck Squamous Cell Carcinoma: A Propensity Score Matching Study. 国際誌

    Jo Omata, Yushi Ueki, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Kohei Saijo, Hisayuki Ota, Takafumi Togashi, Yuichiro Sato, Arata Horii

    Frontiers in surgery   8   753049 - 753049   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective: We aimed to compare the outcomes and safety of chemoradiotherapy (CRT) between elderly and non-elderly patients with head and neck squamous cell carcinoma (HNSCC). It is difficult to assess the causal effect of age because of possible differences in general conditions among individuals. Therefore, we adjusted the background factors of elderly and non-elderly patients using propensity score matching (PSM). Methods: A total of 146 patients with HNSCC who received CRT were divided into an elderly (≥70 years, n = 35) and non-elderly group (<70 years, n = 111). Pre-treatment characteristics, including the performance status, Charlson comorbidity index, body mass index, primary site, and TNM stage were adjusted by PSM. We compared the outcomes and safety of CRT with high-dose single-agent cisplatin (CDDP) as well as outcomes following recurrence between the groups, before and after PSM. Results: The total dose of CDDP administered during CRT was significantly lower in the elderly group before PSM. However, it became comparable to the non-elderly group and adverse events did not differ between the groups following PSM, resulting in a comparable CRT completion rate. Overall-, disease specific-, and progression-free survivals of elderly patients were comparable to those of non-elderly patients following PSM. In contrast, elderly patients with recurrence could receive fewer salvage treatments than their non-elderly counterparts, resulting in worse survival. Conclusions: CRT with high-dose CDDP is safe and effective for the treatment of elderly patients with HNSCC. However, salvage treatments can be rarely conducted for elderly patients with a recurrence, considering a deterioration of their general condition.

    DOI: 10.3389/fsurg.2021.753049

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  • Predicting Cervical Lymph Node Metastasis Following Endoscopic Surgery in Superficial Head and Neck Carcinoma. 国際誌

    Ryuichi Okabe, Yushi Ueki, Riuko Ohashi, Manabu Takeuchi, Satoru Hashimoto, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Hiroshi Matsuyama, Hajime Umezu, Shuji Terai, Yoichi Ajioka, Arata Horii

    Frontiers in surgery   8   813260 - 813260   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Early detection of head and neck carcinoma (HNC) as superficial HNC (SHNC) identified using recently developed optical techniques, such as magnifying endoscopy and narrow-band imaging (NBI), in combination with endoscopic surgeries enables minimally invasive treatment with favorable outcomes for HNC. This study aimed to identify the predictive factors for the rare but important clinical issue of SHNC, namely cervical lymph node metastasis (CLNM), following endoscopic resection. METHODS: Sixty-nine patients with SHNC who underwent endoscopic resection were enrolled in the study. Clinical data, preoperative endoscopic findings, pathological findings, and treatment outcomes were retrospectively reviewed. Because the pharyngeal mucosa lacks the muscularis mucosa, we measured tumor thickness in permanent pathology as an alternative to the depth of invasion. Correlations with the occurrence of CLNM were statistically examined. RESULTS: The 5-year disease-specific survival rate was 100%. Of 69 patients, 3 (4.3%) developed CLNM. All had subepithelial but not epithelial tumors. The 0-IIa type in the macroscopic findings, type B2/B3 vessels in narrow-band imaging, tumors ≥ pathological stage T2, lymphatic invasion, positive surgical margins, and tumor thickness >1,000 μm showed significant correlations with CLNM following endoscopic resection. Furthermore, the classification of type B vessels was significantly associated with tumor thickness. CONCLUSION: The treatment outcomes following endoscopic resection for SHNC were favorable. The risk of CLNM following endoscopic resection in SHNC can be predicted by several preoperative endoscopic and postoperative pathological findings. Among them, the classification of type B vessels, which correlated with both tumor thickness and CLNM, might be a useful predictive factor.

    DOI: 10.3389/fsurg.2021.813260

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  • Role of programmed death-ligand 1 in predicting the treatment outcome of salvage chemotherapy after nivolumab in recurrent/metastatic head and neck squamous cell carcinoma. 国際誌

    Yushi Ueki, Takeshi Takahashi, Hisayuki Ota, Ryusuke Shodo, Keisuke Yamazaki, Arata Horii

    Head & neck   42 ( 11 )   3275 - 3281   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: It was reported that treatment outcomes of the salvage chemotherapy (SCT) following nivolumab are fairly good compared with those of nivolumab itself. However, predictive factors of SCT for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) were not determined. METHODS: Twenty-one R/M HNSCC patients received SCT following nivolumab. The treatment outcome and predictive factors for the favorable response to SCT were investigated. RESULTS: The objective response rate (ORR) and the disease control rate of SCT were 52.4% and 81.0%, respectively. The median progression-free survival and the median overall survival time were 5.4 and 12.9 months, respectively. Patients with positive programmed death-ligand 1 (PD-L1) expression showed greater tumor shrinkage evaluated by the response evaluation criteria in solid tumors and higher ORR than those with negative PD-L1 expression. CONCLUSIONS: Treatment outcome of SCT following nivolumab in R/M HNSCC was favorable. PD-L1 expression may be a predictive factor of SCT.

    DOI: 10.1002/hed.26374

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  • Carotid blowout-a rare but fatal complication of endoscopic submucosal dissection of superficial hypopharyngeal carcinoma after radiotherapy. 国際誌

    Ryuichi Okabe, Yushi Ueki, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Satoru Hashimoto, Arata Horii

    Auris, nasus, larynx   49 ( 1 )   152 - 156   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Endoscopic submucosal dissection (ESD) has gained wide acceptance as a minimally invasive and curative surgery for superficial head and neck carcinoma. However, the safety of ESD for superficial pharyngeal carcinoma after radiotherapy has not been elucidated. Superficial hypopharyngeal carcinoma of the left pyriform sinus developed in a 76-year-old man who had undergone concurrent chemoradiotherapy for T2N2bM0 pyriform sinus carcinoma on the opposite side 12 months before. He underwent ESD without complications. Because tumor invasion into the muscular layer was a concern, the muscular layer was partially resected with the tumor. Twelve days after discharge, he presented with a sore throat and difficulty in swallowing. Endoscopy and computed tomography revealed necrosis due to wound infection with abscess formation around the left carotid artery. The common carotid artery subsequently ruptured. Although the surgical intervention was performed, he passed away 46 days after ESD due to carotid blowout. ESD is a minimally invasive treatment for superficial head and neck carcinoma, but carotid blowout can occur in cases after radiation. Prior radiotherapy and deeper dissection into the muscular layer may hamper wound epithelization, resulting in infection-induced necrosis and carotid blowout. Diligent monitoring of wound healing is essential in patients who have previously undergone irradiation.

    DOI: 10.1016/j.anl.2020.08.020

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  • Sarcopenia predicts a poor treatment outcome in patients with head and neck squamous cell carcinoma receiving concurrent chemoradiotherapy. 国際誌

    Ryusuke Shodo, Keisuke Yamazaki, Yushi Ueki, Takeshi Takahashi, Arata Horii

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   278 ( 6 )   2001 - 2009   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Sarcopenia, defined as a decrease in the skeletal muscle mass and its function, is associated with a poor clinical outcome in several malignancies. We aimed to examine whether sarcopenia can be a predictor of incompletion of concurrent chemoradiotherapy (CCRT) and survival for head and neck cancer (HNC) patients. METHODS: Forty-one male HNC patients who received CCRT were enrolled in the study. Cross-sectional muscle areas at the third lumbar vertebral level were normalized by the squared height of the patients and were termed the lumbar skeletal muscle index (LSMI, cm2/m2), a marker of sarcopenia. Patients were divided into high (30/41, 73%) and low (11/41, 27%) LSMI groups. The LSMI cut-off value was set at 39.7 cm2/m2 based on a receiver operating characteristic curve for incompletion of CCRT. The groups were compared for survival rate by the Kaplan-Meier method. Factors predicting incompletion of CCRT were investigated among several variables. RESULTS: Multivariate analysis showed that a pre-treatment low LSMI (P = 0.033) and age over 70 years (P = 0.023) were the only significant predictors for incompletion of CCRT. The 2-year disease-specific survival (DSS) rate was significantly lower in the low LSMI group (61%) than in the high LSMI group (97%, P = 0.012), whereas there were no differences in the DSS rate between the low and high body mass index groups. CONCLUSION: The prevalence of sarcopenia in HNC patients receiving CCRT was 27%. Its presence before treatment was a significant predictor of incomplete CCRT and poor DSS rate in HNC patients.

    DOI: 10.1007/s00405-020-06273-4

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  • Predicting the treatment outcome of nivolumab in recurrent or metastatic head and neck squamous cell carcinoma: prognostic value of combined performance status and modified Glasgow prognostic score. 国際誌

    Yushi Ueki, Takeshi Takahashi, Hisayuki Ota, Ryusuke Shodo, Keisuke Yamazaki, Arata Horii

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   277 ( 8 )   2341 - 2347   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The importance of nivolumab for recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) is rapidly increasing. However, prognostic factors have not been determined for predicting treatment outcome. We aimed to investigate the prognostic factors in R/M HNSCC patients treated with nivolumab. METHODS: This retrospective study included 42 patients with R/M HNSCC who received nivolumab therapy. Correlations of overall survival (OS) with various patient characteristics including age, recurrent/metastatic site, performance status (PS), programmed death-ligand 1 positivity, body mass index, neutrophil-to-lymphocyte ratio, modified Glasgow prognostic score (mGPS), previous cetuximab administration, and immune-related adverse events were investigated. RESULTS: The overall response rate and disease control rate were 16.7% and 45.2%, respectively. Estimated 1-year OS and progression-free survival (PFS) were 56.4% and 24.5%, respectively. Multivariate analysis revealed that PS = 2 (hazard ratio 0.147; 95% CI 0.041-0.527; p = 0.003) and mGPS = 2 (hazard ratio 0.188; 95% CI, 0.057-0.620; p = 0.006) were independent predictors of poor OS. Given that the PS and mGPS were independent prognostic factors, we classified patients into three groups according to PS and mGPS: Group 1, both PS and mGPS were 0 or 1 (n = 30); Group 2, either PS or mGPS was 2 (n = 9); Group 3, both PS and mGPS were 2 (n = 3). The OS curves were significantly stratified among the three groups. CONCLUSION: The combination of PS and mGPS accurately predicted OS after nivolumab therapy. Preventive intervention to maintain general condition without simultaneously exceeding level 2 of PS and mGPS might be important for improving treatment outcomes of nivolumab.

    DOI: 10.1007/s00405-020-05945-5

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  • 頭頸部皮膚自壊悪性腫瘍におけるにおい対策 デオマジック(商標名)の効果

    山崎 恵介, 太田 久幸, 高橋 剛史, 正道 隆介, 植木 雄志, 堀井 新

    頭頸部癌   46 ( 2 )   167 - 167   2020年7月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 骨転移との鑑別を要したBrown tumor合併副甲状腺癌の一例

    植木 雄志, 高橋 剛史, 太田 久幸, 正道 隆介, 山崎 恵介, 梅津 哉, 堀井 新

    日本内分泌外科学会雑誌   37 ( 1 )   55 - 59   2020年3月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌外科学会  

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  • The association between oral candidiasis and severity of chemoradiotherapy-induced dysphagia in head and neck cancer patients: A retrospective cohort study. 国際誌

    Hirotake Saito, Ryusuke Shodo, Keisuke Yamazaki, Kouji Katsura, Yushi Ueki, Toshimichi Nakano, Tomoya Oshikane, Nobuko Yamana, Satoshi Tanabe, Satoru Utsunomiya, Atsushi Ohta, Eisuke Abe, Motoki Kaidu, Ryuta Sasamoto, Hidefumi Aoyama

    Clinical and translational radiation oncology   20   13 - 18   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and purpose: Concurrent chemoradiotherapy (CCRT) for head and neck cancer (HNC) is a risk factor for oral candidiasis (OC). As Candida spp. are highly virulent, we conducted a retrospective study to determine whether OC increases the severity of dysphagia related to mucositis in HNC patients. Patients and methods: We retrospectively analyzed the cases of consecutive patients with carcinomas of the oral cavity, pharynx, and larynx who underwent CCRT containing cisplatin (CDDP) at our hospital. The diagnosis of OC was based on gross mucosal appearance. We performed a multivariate analysis to determine whether OC was associated with the development of grade 3 dysphagia in the Radiation Therapy Oncology Group (RTOG) Acute Toxicity Criteria. The maximum of the daily opioid doses was compared between the patients with and without OC. Results: We identified 138 HNC patients. OC was observed in 51 patients (37%). By the time of their OC diagnosis, 19 (37%) had already developed grade 3 dysphagia. Among the 30 patients receiving antifungal therapy, 12 (40%) showed clinical deterioration. In the multivariate analysis, OC was independently associated with grade 3 dysphagia (OR 2.75; 95%CI 1.22-6.23; p = 0.015). The patients with OC required significantly higher morphine-equivalent doses of opioids (45 vs. 30 mg/day; p = 0.029). Conclusion: Candida infection causes refractory dysphagia. It is worth investigating whether antifungal prophylaxis reduces severe dysphagia related to candidiasis.

    DOI: 10.1016/j.ctro.2019.10.006

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  • 頭頸部癌外来化学療法における上腕ポートと末梢挿入型中心静脈カテーテルの比較

    正道 隆介, 山崎 恵介, 植木 雄志, 岡部 隆一, 松山 洋, 本田 耕平, 堀井 新

    頭頸部外科   29 ( 2 )   123 - 128   2019年10月

  • 【二次出版】ANL Secondary Publication 日本人頭頸部扁平上皮癌に対する高用量シスプラチン併用化学放射線療法の多施設共同第I/II相試験

    松山 洋, 山崎 恵介, 岡部 隆一, 植木 雄志, 正道 隆介, 尾股 丈, 佐藤 雄一郎, 太田 久幸, 高橋 剛史, 富田 雅彦, 横山 侑輔, 富樫 孝文, 青山 英史, 阿部 英輔, 西條 康夫, 勝良 剛詞, 曽我 麻里恵, 杉田 公, 松本 康男, 土田 恵美子, 堀井 新

    日本耳鼻咽喉科学会会報   122 ( 9 )   1269 - 1270   2019年9月

  • バセドウ病術後に嚥下障害が遷延しANCA関連血管炎と診断した一例

    山崎 恵介, 植木 雄志, 正道 隆介, 高橋 剛史

    日本内分泌外科学会雑誌   36 ( Suppl.3 )   S339 - S339   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌外科学会  

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  • 頭頸部癌再建手術症例における栄養指標の意義

    正道 隆介, 植木 雄志, 岡部 隆一, 山崎 恵介, 本田 耕平, 堀井 新

    頭頸部癌   45 ( 2 )   155 - 155   2019年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 皮膚自壊悪性腫瘍によるにおい対策 デオマジック(登録商標)の効果

    山崎 恵介, 太田 久幸, 正道 隆介, 植木 雄志, 岡部 隆一, 松山 洋, 本田 耕平, 堀井 新

    頭頸部癌   45 ( 2 )   240 - 240   2019年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 再発転移頭頸部扁平上皮癌に対するニボルマブ治療35例の検討 治療成績と予後因子

    植木 雄志, 正道 隆介, 岡部 隆一, 山崎 恵介, 松山 洋, 本田 耕平, 堀井 新

    頭頸部癌   45 ( 2 )   143 - 143   2019年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • CDDP不適の頭頸部扁平上皮癌症例へのセツキシマブ併用放射線療法の治療成績 放射線単独療法との比較

    高橋 剛史, 植木 雄志, 正道 隆介, 富樫 孝文, 岡部 隆一, 山崎 恵介, 本田 耕平, 松山 洋, 富田 雅彦, 佐藤 雄一郎, 堀井 新

    日本耳鼻咽喉科学会会報   122 ( 4 )   635 - 635   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科学会  

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  • 頭頸部癌外来化学療法における上腕ポートと末梢挿入型中心静脈カテーテルの比較

    正道 隆介, 山崎 恵介, 植木 雄志, 岡部 隆一, 松山 洋, 本田 耕平, 堀井 新

    日本耳鼻咽喉科学会会報   122 ( 4 )   636 - 636   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科学会  

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  • Nivolumabを投与した頭頸部癌10症例の臨床像について CM-141試験との比較

    松山 洋, 本田 耕平, 山崎 恵介, 岡部 隆一, 植木 雄志, 富樫 孝文, 正道 隆介, 堀井 新

    頭頸部外科   28 ( 3 )   313 - 318   2019年2月

  • Multicenter phase I/II study of chemoradiotherapy with high-dose CDDP for head and neck squamous cell carcinoma in Japan. 国際誌

    Hiroshi Matsuyama, Keisuke Yamazaki, Ryuichi Okabe, Yushi Ueki, Ryusuke Shodo, Jo Omata, Yuichiro Sato, Hisayuki Ota, Takeshi Takahashi, Masahiko Tomita, Yusuke Yokoyama, Takafumi Togashi, Hidefumi Aoyama, Eisuke Abe, Yasuo Saijo, Kouji Katsura, Marie Soga, Tadashi Sugita, Yasuo Matsumoto, Emiko Tsuchida, Arata Horii

    Auris, nasus, larynx   45 ( 5 )   1086 - 1092   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Recent data indicated that concurrent chemoradiotherapy (CCRT) using high dose cisplatin (CDDP) is the most useful treatment for advanced head and neck squamous cell carcinoma (SCC). Regarding the dose of CDDP, 100mg/m2 is most recommended in Western countries. However, in terms of a balance of efficacy and adverse events, appropriate dose of cytotoxic drugs such as CDDP may be different among the different ethnic groups. In this multicenter phase I/II study, we aimed to identify the optimal dose of CDDP in CCRT for patients with advanced head and neck SCC in the Japanese. METHODS: Patients were eligible for inclusion if they had head and neck SCC that was treated with radical CCRT comprising whole-neck irradiation of the primary lesion and level II-IV lymph nodes on both sides. For the phase I study, a CDDP dose was 70mg/m2 for level 0, 80mg/m2 for level 1, and 100mg/m2 for level 2. Maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) were examined by phase I trial, by which CDDP dose for phase II was determined. The primary endpoint for the phase II was CCRT completion rate, and the secondary endpoint was full-dose-CCRT completion rate, the percentage of patients receiving a total CDDP dose of ≥200mg/m2, response rate, and incidences of adverse events. RESULTS: A CDDP dose of 100mg/m2 was the MTD for phase I, and the recommended dose for phase II was 80 mg/m2. Forty-seven patients were evaluated in the phase II trial. CCRT completion rate, full-dose-CCRT rate, and the percentage of patients receiving a total CDDP dose of ≥200mg/m2, were 93.6%, 78.7%, and 93.6%, respectively. One patient (2.1%) developed grade 2 renal dysfunction, and no patient developed febrile neutropenia or a grade 4 adverse event. CONCLUSION: The present phase I study indicated that a CDDP dose of 80mg/m2 is the optimal dose in terms of safety. The phase II study revealed that CCRT completion rate, response rate, and rates of adverse events were not inferior for a CDDP dose of 80mg/m2 as compared with a dose of 100mg/m2, and a dose of 80mg/m2 is therefore recommended in CCRT for the Japanese. This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; identification No. UMIN000010369).

    DOI: 10.1016/j.anl.2018.02.008

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  • 多発遠隔転移を伴った副甲状腺癌の1例

    植木 雄志, 山崎 恵介, 正道 隆介, 岡部 隆一, 松山 洋, 本田 耕平, 堀井 新

    日本内分泌・甲状腺外科学会雑誌   35 ( Suppl.2 )   S332 - S332   2018年10月

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    記述言語:日本語   出版者・発行元:日本内分泌外科学会・日本甲状腺外科学会  

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  • 下咽頭癌化学放射線治療における嚥下リハビリテーションの有用性についての検討

    山崎 恵介, 森 香織, 正道 隆介, 富樫 孝文, 植木 雄志, 岡部 隆一, 松山 洋, 本田 耕平, 堀井 新

    頭頸部癌   44 ( 2 )   151 - 151   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 中・下咽頭表在癌における拡大内視鏡所見と深達度の検討

    岡部 隆一, 松山 洋, 正道 隆介, 富樫 孝文, 植木 雄志, 山崎 恵介, 本田 耕平, 堀井 新

    頭頸部癌   44 ( 2 )   205 - 205   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 当科における再発頭頸部扁平上皮癌のCetuximab併用1次治療不応に対する2次治療の有効性と安全性の検討

    富樫 孝文, 正道 隆介, 植木 雄志, 岡部 隆一, 山崎 恵介, 本田 耕介, 松山 洋, 堀井 新

    頭頸部癌   44 ( 2 )   160 - 160   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 頭頸部癌に対するNivolumab投与報告

    松山 洋, 本田 耕平, 山崎 恵介, 岡部 隆一, 植木 雄志, 富樫 孝文, 正道 隆介, 堀井 新

    頭頸部癌   44 ( 2 )   172 - 172   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 頭頸部癌化学放射線療法症例のサルコペニア調査

    正道 隆介, 松山 洋, 富樫 孝文, 岡部 隆一, 山崎 恵介, 本田 耕介, 堀井 新

    頭頸部癌   44 ( 2 )   150 - 150   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • Asymptomatic diffuse idiopathic skeletal hyperostosis as a potential risk for severe dysphagia following partial laryngopharyngectomy

    Ryusuke Shodo, Yuichiro Sato, Hisayuki Ota, Yushi Ueki, Arata Horii

    ACTA OTO-LARYNGOLOGICA CASE REPORTS   3 ( 1 )   29 - 33   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/23772484.2018.1477508

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  • Clavicle fracture with osteomyelitis after neck dissection and post-operative radiotherapy: case report. 国際誌

    R Shodo, Y Sato, H Ota, A Horii

    The Journal of laryngology and otology   131 ( 11 )   1026 - 1029   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Non-traumatic bone fractures in cancer patients are usually pathological fractures due to bone metastases. In head and neck cancer patients, clavicle stress fractures may occur as a result of atrophy of the trapezius muscle after neck dissection in which the accessory nerve becomes structurally or functionally damaged. CASE REPORT: A 71-year-old man underwent modified radical neck dissection with accessory nerve preservation and post-operative radiotherapy for submandibular lymph node metastases of tongue cancer. Four weeks after the radiotherapy, a clavicle fracture, with osteomyelitis and abscess formation in the pectoralis major muscle, occurred. Unlike in simple stress fracture, long-term antibiotic administration and drainage surgery were required to suppress the inflammation. CONCLUSION: As seen in the present patient, clavicle stress fractures may occur even after neck dissection in which the accessory nerve is preserved, and may be complicated by osteomyelitis and abscess formation owing to risk factors such as radiotherapy, tracheostomy and contiguous infection.

    DOI: 10.1017/S0022215117001748

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  • 頭頸部扁平上皮癌Stage IVC症例の検討

    尾股 丈, 横山 侑輔, 高橋 剛史, 正道 隆介, 太田 久幸, 富樫 孝文, 植木 雄志, 岡部 隆一, 山崎 恵介, 松山 洋, 堀井 新, 佐藤 雄一郎, 富田 雅彦

    頭頸部癌   43 ( 2 )   215 - 215   2017年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 上咽頭癌化学放射線療法後の補助化学療法

    横山 侑輔, 尾股 丈, 高橋 剛史, 正道 隆介, 富樫 孝文, 植木 雄志, 岡部 隆一, 山崎 恵介, 松山 洋, 堀井 新, 佐藤 雄一郎, 太田 久幸, 富田 雅彦

    頭頸部癌   43 ( 2 )   178 - 178   2017年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 新潟県の頭頸部扁平上皮癌に対するCCRTの現状 県内多施設共同研究の最終報告

    松山 洋, 山崎 恵介, 岡部 隆一, 植木 雄志, 富樫 孝文, 横山 侑輔, 堀井 新, 佐藤 雄一郎, 正道 隆介, 太田 久幸, 富田 雅彦, 尾股 丈

    頭頸部癌   43 ( 2 )   186 - 186   2017年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • Three-dimensional reconstruction of root cells and interdental cells in the rat inner ear by serial section scanning electron microscopy.

    Ryusuke Shodo, Manabu Hayatsu, Daisuke Koga, Arata Horii, Tatsuo Ushiki

    Biomedical research (Tokyo, Japan)   38 ( 4 )   239 - 248   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In the cochlea, a high K+ environment in the endolymph is essential for the maintenance of normal hearing function, and the transport of K+ ions through gap junctions of the cochlear epithelium is thought to play an important role in endolymphatic homeostasis. The aim of the present study was to demonstrate the three-dimensional (3D) ultrastructure of spiral ligament root cells and interdental cells, which are located at both ends of the gap junction system of the cochlea epithelium. Serial semi-thin sections of plastic-embedded rat cochlea were mounted on glass slides, stained with uranyl acetate and lead citrate, and observed by scanning electron microscopy (SEM) using the backscattered electron (BSE) mode. 3D reconstruction of BSE images of serial sections revealed that the root cells were linked together to form a branched structure like an elaborate "tree root" in the spiral ligament. The interdental cells were also connected to each other, forming a comb-shaped cellular network with a number of cellular strands in the spiral limbus. Furthermore, TEM studies of ultra-thin sections revealed the rich presence of gap junctions in both root cells and interdental cells. These findings suggest the possibility that both root cells and interdental cells contribute to K+ circulation as the end portion of the epithelial cell gap junction system of the cochlea.

    DOI: 10.2220/biomedres.38.239

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  • 嗅神経芽細胞腫2症例に対する化学療法の経験

    横山 侑輔, 山崎 恵介, 尾股 丈, 高橋 剛史, 太田 久幸, 正道 隆介, 山崎 洋大, 植木 雄志, 岡部 隆一, 富樫 孝文, 松山 洋, 堀井 新

    頭頸部癌   42 ( 2 )   159 - 159   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • CDDP+VP-16先行後放射線療法を行った頭頸部小細胞癌の4例

    松山 洋, 山崎 恵介, 岡部 隆一, 植木 雄志, 山崎 洋大, 正道 隆介, 太田 久幸, 高橋 剛史, 尾股 丈, 横山 侑輔, 堀井 新, 富樫 孝文

    頭頸部癌   42 ( 2 )   173 - 173   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 新潟県における頭頸部癌CCRTのレジメン統一への動き 高用量CDDP+RT

    松山 洋, 佐藤 雄一郎, 富田 雅彦, 山崎 恵介, 岡部 隆一, 植木 雄志, 富樫 孝文, 山崎 洋大, 正道 隆介, 太田 久幸, 高橋 剛史, 堀井 新

    頭頸部癌   42 ( 1 )   70 - 75   2016年4月

  • 新潟県内頭頸部癌治療の統一と集約化への動き

    松山 洋, 山崎 恵介, 岡部 隆一, 植木 雄志, 堀井 新, 佐藤 雄一郎, 正道 隆介, 太田 久幸, 富田 雅彦, 富樫 孝文

    日本耳鼻咽喉科学会会報   119 ( 4 )   684 - 684   2016年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科学会  

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  • High-resolution imaging by scanning electron microscopy of semithin sections in correlation with light microscopy. 国際誌

    Daisuke Koga, Satoshi Kusumi, Ryusuke Shodo, Yukari Dan, Tatsuo Ushiki

    Microscopy (Oxford, England)   64 ( 6 )   387 - 94   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In this study, we introduce scanning electron microscopy (SEM) of semithin resin sections. In this technique, semithin sections were adhered on glass slides, stained with both uranyl acetate and lead citrate, and observed with a backscattered electron detector at a low accelerating voltage. As the specimens are stained in the same manner as conventional transmission electron microscopy (TEM), the contrast of SEM images of semithin sections was similar to TEM images of ultrathin sections. Using this technique, wide areas of semithin sections were also observed by SEM, without the obstruction of grids, which was inevitable for traditional TEM. This study also applied semithin section SEM to correlative light and electron microscopy. Correlative immunofluorescence microscopy and immune-SEM were performed in semithin sections of LR white resin-embedded specimens using a FluoroNanogold-labeled secondary antibody. Because LR white resin is hydrophilic and electron stable, this resin is suitable for immunostaining and SEM observation. Using correlative microscopy, the precise localization of the primary antibody was demonstrated by fluorescence microscopy and SEM. This method has great potential for studies examining the precise localization of molecules, including Golgi- and ER-associated proteins, in correlation with LM and SEM.

    DOI: 10.1093/jmicro/dfv042

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  • 甲状腺腫瘍にて診断された成人全身型筋線維腫症の1例

    植木 雄志, 佐藤 雄一郎, 森 香織, 正道 隆介, 畠野 宏史, 川崎 隆, 本間 慶一

    日本内分泌・甲状腺外科学会雑誌   32 ( 3 )   211 - 214   2015年9月

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    記述言語:日本語   出版者・発行元:日本内分泌外科学会・日本甲状腺外科学会  

    DOI: 10.11226/jaesjsts.32.3_211

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  • A case of fatal interstitial pneumonia during treatment of radiotherapy plus cetuximab for patient with head and neck carcinoma

    Hiroshi Matsuyama, Katsuaki Asakawa, Kaori Shinbori, Ryusuke Shodo, Hirotomo Yamazaki, Yushi Ueki, Shuji Izumi, Satoru Miura, Sugata Takahashi

    International Cancer Conference Journal   4 ( 3 )   162 - 166   2015年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s13691-014-0191-5

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    その他リンク: http://link.springer.com/article/10.1007/s13691-014-0191-5/fulltext.html

  • 頭頸部領域に再発を繰り返した類上皮血管内皮腫の1例

    尾股 丈, 松山 洋, 正道 隆介, 山崎 洋大, 植木 雄志, 山崎 恵介, 山本 裕, 高橋 姿

    頭頸部外科   25 ( 1 )   55 - 60   2015年6月

  • 新潟県における頭頸部癌CCRTのレジメン統一への動き 高用量CDDP+RT

    松山 洋, 岡部 隆一, 富樫 孝文, 正道 隆介, 高橋 姿, 佐藤 雄一郎, 植木 雄志, 山崎 恵介, 富田 雅彦, 山崎 洋大

    頭頸部癌   41 ( 2 )   218 - 218   2015年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • Therapeutic outcome after resection of pulmonary metastasis from head and neck carcinomas. 国際誌

    Keisuke Yamazaki, Ryusuke Shodo, Yushi Ueki, Hiroshi Matsuyama, Sugata Takahashi

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India   67 ( Suppl 1 )   124 - 8   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Hematogenous metastasis is the most common form of metastasis in head and neck cancer, and reports have described successful resection of pulmonary metastases of such cancers. We report treatment outcomes after surgical resection of pulmonary metastases of head and neck cancer and identify prognostic factors. This clinicopathologic study investigated the clinical records of 16 patients with pulmonary metastases of head and neck cancer (excepting cases of thyroid cancer) who had undergone metastasectomy at our center during the period 2001-2012. The mean age of the 16 patients (11 men and 5 women) was 62.1 years. The mean interval between completion of successful treatment of the primary tumor and detection of pulmonary metastasis was 21 months (range, 6-56 months). All patients underwent pulmonary resection. The overall 1-year survival rate was 79.4 %, and the 2- to 5-year survival rate was 63.2 %. These rates compare favorably to those in previous reports on resection of pulmonary metastases. When prognostic factors for survival rates were compared, the factors associated with a negative prognosis were a disease-free interval of <12 months and partial resection of pulmonary metastases. Multivariate analysis did not reveal any prognostic factors associated with negative outcomes. Surgical resection of pulmonary metastases of head and neck cancer might improve outcomes.

    DOI: 10.1007/s12070-014-0799-y

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  • 喉頭に生じた類基底細胞扁平上皮癌の1例

    正道 隆介, 松山 洋, 山崎 洋大, 富樫 孝文, 植木 雄志, 岡部 隆一, 山本 裕, 髙橋 姿

    頭頸部癌   41 ( 1 )   51 - 56   2015年

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    記述言語:日本語   出版者・発行元:Japan Society for Head and Neck Cancer  

    類基底細胞扁平上皮癌は,類基底細胞成分と扁平上皮癌成分が混在する稀な組織型である。症例は61歳男性,嗄声と咽頭痛を主訴に当科を受診した。喉頭内視鏡では喉頭前庭左側から両声帯に至る腫瘍性病変と左声帯麻痺があり,生検で扁平上皮癌を認めた。画像所見と併せて,喉頭癌(声門上型扁平上皮癌,T3N2bM0,stage IV A)と診断した。術前化学療法後に喉頭全摘術,両頸部郭清術を施行した。手術標本の病理所見より類基底細胞扁平上皮癌の診断となり,転移リンパ節に節外浸潤を認めたため術後放射線照射を施行したが,早期に多発肺転移を生じた。CDDP,5-FU,Cetuximab投与により肺転移巣は一時的に縮小したが,その後急激に増大した。類基底細胞扁平上皮癌は遠隔転移が多く予後不良な組織型とされており,強力な化学療法を含む集学的治療の必要性が示唆された。

    DOI: 10.5981/jjhnc.41.51

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    その他リンク: http://search.jamas.or.jp/link/ui/2015238877

  • セツキシマブ併用放射線治療中に血小板減少をきたした高齢下咽頭癌例

    植木 雄志, 金丸 明子, 正道 隆介, 山本 裕, 高橋 姿

    耳鼻咽喉科臨床   108 ( 1 )   63 - 69   2015年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:耳鼻咽喉科臨床学会  

    DOI: 10.5631/jibirin.108.63

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  • 頭頸部領域に生じた高分化型脂肪肉腫の3例

    正道 隆介, 太田 久幸, 山崎 恵介, 松山 洋, 高橋 姿

    頭頸部癌   40 ( 1 )   75 - 80   2014年4月

  • 頭頸部癌肺転移切除症例の検討

    山崎 恵介, 正道 隆介, 松山 洋, 高橋 姿

    頭頸部癌   39 ( 2 )   150 - 150   2013年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 当院における中下咽頭表在癌症例の検討

    松山 洋, 尾股 丈, 正道 隆介, 山崎 恵介, 高橋 姿

    頭頸部癌   39 ( 2 )   181 - 181   2013年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 頭頸部領域に生じた高分化型脂肪肉腫の3症例

    正道 隆介, 太田 久幸, 山崎 恵介, 松山 洋, 高橋 姿

    頭頸部癌   39 ( 2 )   204 - 204   2013年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 声門下狭窄を伴った先天性喉頭横隔膜症の1例

    松山 洋, 正道 隆介, 山崎 恵介, 渡辺 順, 富田 雅彦, 佐藤 克郎, 高橋 姿, 久 育男

    頭頸部外科   22 ( 3 )   311 - 316   2013年2月

  • 新潟大学における頭頸部悪性腫瘍症例の20年間の変遷

    佐藤 克郎, 松山 洋, 山崎 恵介, 正道 隆介, 高橋 姿

    頭頸部癌   38 ( 2 )   147 - 147   2012年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 当科における舌癌の臨床統計

    正道 隆介, 太田 久幸, 山崎 恵介, 松山 洋, 佐藤 克郎, 高橋 姿

    頭頸部癌   38 ( 2 )   259 - 259   2012年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 粘表皮癌45例の臨床病理学的検討

    山崎 恵介, 正道 隆介, 松山 洋, 佐藤 克郎, 高橋 姿

    頭頸部癌   38 ( 2 )   201 - 201   2012年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 当科における遊離皮弁を用いた頭頸部癌再建手術の検討

    松山 洋, 太田 久幸, 正道 隆介, 山崎 恵介, 佐藤 克郎, 高橋 姿

    頭頸部癌   38 ( 2 )   154 - 154   2012年5月

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    記述言語:日本語   出版者・発行元:(一社)日本頭頸部癌学会  

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  • 新潟県における頭頸部癌診療の現状と目標

    山崎 恵介, 正道 隆介, 松山 洋, 佐藤 克郎, 高橋 姿, 佐藤 雄一郎

    日本耳鼻咽喉科学会会報   115 ( 4 )   459 - 459   2012年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科学会  

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▶ 全件表示

MISC

  • Multicenter phase i/II study of chemoradiotherapy with high-dose cddp for head and neck squamous cell carcinoma in Japan

    Hiroshi Matsuyama, Keisuke Yamazaki, Ryuichi Okabe, Yushi Ueki, Ryusuke Shodo, Jo Omata, Yuichiro Sato, Hisayuki Ota, Takeshi Takahashi, Masahiko Tomita, Yusuke Yokoyama, Takafumi Togashi, Hidefumi Aoyama, Eisuke Abe, Yasuo Saijo, Kouji Katsura, Marie Soga, Tadashi Sugita, Yasuo Matsumoto, Emiko Tsuchida, Ai'ata Horii

    Journal of Otolaryngology of Japan   122 ( 9 )   1269 - 1270   2019年

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    記述言語:日本語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:Oto-Rhino-Laryngological Society of Japan Inc.  

    DOI: 10..3950/jibiinkoka.122.1269

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  • 7 耳下腺原発脂腺癌の1症例(I.一般演題,第69回新潟癌治療研究会)

    正道 隆介, 森田 由香, 花澤 秀行, 植木 雄志, 溝江 純悦

    新潟医学会雑誌   124 ( 3 )   173 - 173   2010年3月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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共同研究・競争的資金等の研究

  • 頭頸部癌化学放射線療法症例におけるオステオサルコぺニア改善の取り組み

    研究課題/領域番号:24K19765

    2024年4月 - 2027年3月

    制度名:科学研究費助成事業

    研究種目:若手研究

    提供機関:日本学術振興会

    正道 隆介

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    配分額:3640000円 ( 直接経費:2800000円 、 間接経費:840000円 )

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  • 蝸牛外側壁構成細胞の加齢性変化-連続切片走査型電子顕微鏡法による3次元解析-

    研究課題/領域番号:18K16835

    2018年4月 - 2021年3月

    制度名:科学研究費助成事業 若手研究

    研究種目:若手研究

    提供機関:日本学術振興会

    正道 隆介

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    配分額:3250000円 ( 直接経費:2500000円 、 間接経費:750000円 )

    加齢性難聴はコミュニケーション障害をきたし高齢者の孤立、抑うつ、認知機能低下にも繋がり、国民的課題であると言えるが、有効な予防法や治療法は確立されていない。加齢性難聴の組織学的所見については過去にも報告があり血管条の萎縮はそのひとつとして挙げられるが、血管条を含む蝸牛外側壁の立体構造についての研究はほとんど行われていない。研究者は連続切片走査型電子顕微鏡法により、これまで観察が困難であった蝸牛外側壁の構成細胞、特に根細胞の立体配列について、蝸牛外側壁のラセン靭帯下部領域において樹木根状の細胞集塊を形成し、II型線維細胞が分布するラセン靭帯下部領域に伸展していることを既に示し報告した(Shodo et al. Biomed Res 2017)。この手法を応用し、蝸牛外側壁構成細胞の加齢性変化を3次元的に解明することを目的とする。研究計画に基づき、平成31年(令和元年)度は正常モデルと加齢性難聴モデルの観察を行った。光学顕微鏡での観察を主に行い、電子顕微鏡での観察は遅れている。総合的に進捗状況としては遅れている。

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