Updated on 2025/04/04

写真a

 
MITSUMA Yusuke
 
Organization
University Medical and Dental Hospital Uonuma Institute of Community Medicine Specially Appointed Lecturer
Title
Specially Appointed Lecturer
External link

Degree

  • 修士(医学) ( 2021.3   愛媛大学 )

  • 修士 ( 2011.4   愛媛大学 )

Research History

  • Niigata University   UONUMA CHIIKI IRYO KYOIKU CENTER, University Medical and Dental Hospital   Specially Appointed Lecturer

    2023.4

  • Niigata University   University Medical and Dental Hospital Anesthesiology   Assistant Professor

    2020.4 - 2022.3

 

Papers

  • Low-dose Droperidol Reduces the Amplitude of Transcranial Electrical Motor-evoked Potential: A Randomized, Double-blind, Placebo-controlled Trial. International journal

    Yusuke Mitsuma, Kenta Furutani, Hiroyuki Deguchi, Yoshinori Kamiya, Takahiro Tanaka, Nobutaka Kitamura, Hiroshi Baba

    Journal of neurosurgical anesthesiology   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Low-dose droperidol has been reported to suppress the amplitude of transcranial electrical motor-evoked potentials (TCE-MEPs), but no randomized controlled trials have been conducted to assess this. This randomized, double-blinded, placebo-controlled trial aimed to test the hypothesis that low-dose droperidol reduced TCE-MEP amplitudes. METHODS: Twenty female patients with adolescent idiopathic scoliosis, aged between 12 and 20 years, and scheduled to undergo corrective surgery were randomly allocated to receive droperidol (20 µg/kg) or 0.9% saline. After recording baseline TCE-MEPs, the test drug was administered, following which TCE-MEP recordings were carried out every 2 minutes for up to 10 minutes. The primary outcome was the minimum relative TCE-MEP amplitude (peak-to-peak amplitude, percentage of baseline value) recorded in the left tibialis anterior muscle. Secondary outcomes included minimum relative MEP amplitudes recorded from all other muscle groups monitored in the study. Data are expressed as medians (interquartile range). RESULTS: The TCE-MEP amplitude of the left tibialis anterior muscle was significantly reduced following droperidol administration compared with saline (37% [30% to 55%] vs. 76% [58% to 93%], respectively, P<0.01). In the other muscles, the amplitudes were reduced in the droperidol group, except for the bilateral abductor pollicis brevis and the left quadriceps femoris muscles. The relative amplitude of the bilateral F waves recorded from the gastrocnemius was decreased in the droperidol group. CONCLUSIONS: Low-dose droperidol (20 µg/kg) reduced TCE-MEP amplitudes. Anesthesiologists should pay attention to the timing of droperidol administration during intraoperative TCE-MEP recordings, even if used in a low dose.

    DOI: 10.1097/ANA.0000000000000784

    PubMed

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  • 成人ムコ多糖症II型患者の開心術における周術期気道管理

    三ツ間 祐介, 清水 大喜, 松田 敬一郎, 本田 博之, 今井 英一, 馬場 洋

    麻酔   70 ( 6 )   602 - 605   2021.6

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    Language:Japanese   Publisher:克誠堂出版(株)  

    成人ムコ多糖症II型患者では、周術期の気道・呼吸管理が問題になる。本症例は意識下、気管支鏡ガイド下に経口挿管を試みたが、ムコ多糖の蓄積による気道のねじれと狭窄のため困難であった。経鼻アプローチに変更すると、咽頭軸との角度が緩やかになり比較的容易に挿管できた。成人症例では経鼻挿管が有用である可能性が示唆された。(著者抄録)

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    Other Link: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J01397&link_issn=&doc_id=20210601120006&doc_link_id=%2Fad3msuie%2F2021%2F007006%2F007%2F0602-0605%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fad3msuie%2F2021%2F007006%2F007%2F0602-0605%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • Propofol reduces the amplitude of transcranial electrical motor-evoked potential without affecting spinal motor neurons: a prospective, single-arm, interventional study.

    Hiroyuki Deguchi, Kenta Furutani, Yusuke Mitsuma, Yoshinori Kamiya, Hiroshi Baba

    Journal of anesthesia   35 ( 3 )   434 - 441   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: Propofol inhibits the amplitudes of transcranial electrical motor-evoked potentials (TCE-MEP) in a dose-dependent manner. However, the mechanisms of this effect remain unknown. Hence, we investigated the spinal mechanisms of the inhibitory effect of propofol on TCE-MEP amplitudes by evaluating evoked electromyograms (H-reflex and F-wave) under general anesthesia. METHODS: We conducted a prospective, single-arm, interventional study including 15 patients scheduled for spine surgery under general anesthesia. Evoked electromyograms of the soleus muscle and TCE-MEPs were measured at three propofol concentrations using target-controlled infusion (TCI: 2.0, 3.0, and 4.0 µg/mL). The primary outcome measure was the left H-reflex amplitude during TCI of 4.0- compared to 2.0-µg/mL propofol administration. RESULTS: The median [interquartile range] amplitudes of the left H-reflex were 4.71 [3.42-6.60] and 5.6 [4.17-7.46] in the 4.0- and 2.0-μg/mL TCI groups (p = 0.4, Friedman test), respectively. There were no significant differences in the amplitudes of the right H-reflex and the bilateral F-wave among these groups. However, the TCE-MEP amplitudes significantly decreased with increased propofol concentrations (p < 0.001, Friedman test). CONCLUSION: Propofol did not affect the amplitudes of the H-reflex and the F-wave, whereas TCE-MEP amplitudes were reduced at higher propofol concentrations. These results suggested that propofol can suppress the TCE-MEP amplitude by inhibiting the supraspinal motor pathways more strongly than the excitability of the motor neurons in the spinal cord.

    DOI: 10.1007/s00540-021-02927-7

    PubMed

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  • Epidural Administration of Ropivacaine Reduces the Amplitude of Transcranial Electrical Motor-Evoked Potentials: A Double-Blinded, Randomized, Controlled Trial. International journal

    Kenta Furutani, Toshiyuki Tobita, Hideaki Ishii, Hiroyuki Deguchi, Yusuke Mitsuma, Yoshinori Kamiya, Hiroshi Baba

    Anesthesia and analgesia   132 ( 4 )   1092 - 1100   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: An epidurally administered local anesthetic acts primarily on the epidural nerve roots and can act directly on the spinal cord through the dural sleeve. We hypothesized that epidurally administered ropivacaine would reduce the amplitude of transcranial electrical motor-evoked potentials by blocking nerve conduction in the spinal cord. Therefore, we conducted a double-blind, randomized, controlled trial. METHODS: Thirty adult patients who underwent lung surgery were randomly allocated to 1 of 3 groups, based on the ropivacaine concentration: the 0.2% group, the 0.375% group, and the 0.75% group. The attending anesthesiologists, neurophysiologists, and patients were blinded to the allocation. The epidural catheter was inserted at the T5-6 or T6-7 interspace by a paramedian approach, using the loss of resistance technique with normal saline. General anesthesia was induced and maintained using propofol and remifentanil. Transcranial electrical motor-evoked potentials were elicited by a train of 5 pulses with an interstimulus interval of 2 milliseconds by using a constant-voltage stimulator and were recorded from the tibialis anterior muscle. Somatosensory-evoked potentials (SSEPs) were evoked by electrical tibial nerve stimulation at the popliteal fossa. After measuring the baseline values of these evoked potentials, 10 mL of epidural ropivacaine was administered at the 0.2%, 0.375%, or 0.75% concentration. The baseline amplitudes and latencies recorded before administering ropivacaine were defined as 100%. Our primary end point was the relative amplitude of the motor-evoked potentials at 60 minutes after the epidural administration of ropivacaine. We analyzed the amplitudes and latencies of these evoked potentials by using the Kruskal-Wallis test and used the Dunn multiple comparison test as the post hoc test for statistical analysis. RESULTS: The data are expressed as the median (interquartile range). Sixty minutes after epidurally administering ropivacaine, the motor-evoked potential amplitude was lower in the 0.75% group (7% [3%-18%], between-group difference P < .001) and in the 0.375% group (52% [43%-59%]) compared to that in the 0.2% group (96% [89%-105%]). The latency of SSEP was longer in the 0.75% group compared to that in the 0.2% group, but the amplitude was unaffected. CONCLUSIONS: Epidurally administered high-dose ropivacaine lowered the amplitude of motor-evoked potentials and prolonged the onset latencies of motor-evoked potentials and SSEPs compared to those in the low-dose group. High-dose ropivacaine can act on the motor pathway through the dura mater.

    DOI: 10.1213/ANE.0000000000005236

    PubMed

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  • Precautions with right supraclavicular approach and oximetry central venous catheter. International journal

    Tomohiro Yamamoto, Yusuke Mitsuma, Ehrenfried Schindler

    Anaesthesiology intensive therapy   2021.3

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MISC

  • 小児患者の大動脈弓再建術における経大腿動脈送血法

    山本 知裕, 松田 敬一郎, 清野 豊, 三ツ間 祐介, 今井 英一

    Cardiovascular Anesthesia   23 ( Suppl. )   [DP2 - 03]   2019.9

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    Language:Japanese   Publisher:(一社)日本心臓血管麻酔学会  

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Research Projects

  • Low-dose droperidol reduces the amplitude of transcranial electrical motor-evoked potential

    Grant number:18K16440

    2018.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Early-Career Scientists

    Awarding organization:Japan Society for the Promotion of Science

    Mitsuma Yusuke

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    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    Background: Low-dose droperidol can suppress the amplitude of transcranial electrical motor-evoked potentials (TCE-MEPs); however, no randomized controlled trials have been conducted to assess this. This randomized, double-blinded, placebo-controlled trial aimed to test our hypothesis that low-dose droperidol reduced TCE-MEP amplitudes.
    Results: The TCE-MEP amplitude of the left tibialis anterior muscle was significantly reduced in the droperidol group compared to that in the saline group (37% [30%-55%] and 76% [58%-93%], respectively, P<0.01). In the other muscles, the amplitudes were reduced in the droperidol group.
    Conclusions: Low-dose droperidol (20 μg/kg) reduced TCE-MEP amplitudes. The anesthesiologists should pay attention to the timing of droperidol administration during intraoperative TCE-MEP recordings, even if they use a low dose.

    researchmap